annotate macros.xml @ 2:54b6b4d0613a draft default tip

planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 261c6a4ae771a24a27a23cd808a4ae6e5248939b
author iuc
date Thu, 01 Oct 2015 11:13:19 -0400
parents b5066aa77fea
children
Ignore whitespace changes - Everywhere: Within whitespace: At end of lines:
rev   line source
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62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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1 <?xml version="1.0"?>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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2 <macros>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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3 <xml name="requirements">
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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4 <requirements>
2
54b6b4d0613a planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 261c6a4ae771a24a27a23cd808a4ae6e5248939b
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5 <requirement type="package" version="3.1b1">hmmer</requirement>
0
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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6 <yield/>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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7 </requirements>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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8 </xml>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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9 <token name="@WRAPPER_VERSION@">0.1</token>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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10 <xml name="stdio">
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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11 <stdio>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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12 <!-- Anything other than zero is an error -->
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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13 <exit_code range="1:"/>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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14 <exit_code range=":-1"/>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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15 <!-- In case the return code has not been set propery check stderr too -->
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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16 <regex match="Error:"/>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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17 <regex match="Exception:"/>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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18 </stdio>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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19 </xml>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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20 <token name="@THRESHOLDS@">
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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21 -E $E
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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22 --domE $domE
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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23
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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24 #if $T:
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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25 -T $T
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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26 #end if
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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27
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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28 #if $domT:
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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29 --domT $domT
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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30 #end if
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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31
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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32 #if $incE:
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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33 --incE $incE
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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34 #end if
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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35
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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36 #if $incT:
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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37 --incT $incT
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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38 #end if
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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39
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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40 #if $incdomE:
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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41 --incdomE $incdomE
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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42 #end if
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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43
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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44 #if $incdomT:
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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45 --incdomT $incdomT
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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46 #end if
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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47 </token>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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48 <xml name="thresholds_xml">
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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49 <!-- Options controlling reporting thresholds -->
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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50 <param name="E" label="report sequences &lt;= this E-Value threshold in output" help="(-E)" value="10.0" type="float" min="0"/>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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51 <param name="domE" label="report domains &lt;= this E-Value threshold in output" help="(--domE)" value="10.0" type="float" min="0"/>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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52 <param name="T" label="report sequences &gt;= this score threshold in output" help="(-T)" type="float" optional="True"/>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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53 <param name="domT" label="report domains &gt;= this score threshold in output" help="(--domT)" type="float" optional="True"/>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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54 <!-- Options controlling inclusion (significance) thresholds -->
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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55 <param name="incE" label="consider sequences &lt;= this E-Value threshold as significant" help="(--incE)" type="float" optional="True"/>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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56 <param name="incdomE" label="consider domains &lt;= this E-Value threshold as significant" help="(--incdomE)" type="float" optional="True"/>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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57 <param name="incT" label="consider sequences &gt;= this score threshold as significant" help="(--incT)" type="float" optional="True"/>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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58 <param name="incdomT" label="consider domains &gt;= this score threshold as significant" help="(--incdomT)" type="float" optional="True"/>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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59 </xml>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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60 <token name="@THRESHOLDS_NODOM@">
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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61 -E $E
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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62
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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63 #if $T:
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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64 -T $T
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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65 #end if
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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66
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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67 #if $incE:
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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68 --incE $incE
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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69 #end if
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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70
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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71 #if $incT:
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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72 --incT $incT
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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73 #end if
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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74 </token>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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75 <xml name="thresholds_nodom">
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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76 <!-- Options controlling reporting thresholds -->
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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77 <param name="E" label="report sequences &lt;= this E-Value threshold in output" help="(-E)" value="10.0" type="float" min="0"/>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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78 <param name="T" label="report sequences &gt;= this score threshold in output" help="(-T)" type="float" optional="True"/>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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79 <!-- Options controlling inclusion (significance) thresholds -->
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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80 <param name="incE" label="consider sequences &lt;= this E-Value threshold as significant" help="(--incE)" type="float" optional="True"/>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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81 <param name="incT" label="consider sequences &gt;= this score threshold as significant" help="(--incT)" type="float" optional="True"/>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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82 </xml>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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83 <token name="@ACCEL_HEUR@">
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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84 $max
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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85 --F1 $F1
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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86 --F2 $F2
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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87 --F3 $F3
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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88 $nobias
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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89
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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90 </token>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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91 <xml name="accel_heur_xml">
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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diff changeset
92 <!-- Options controlling acceleration heuristics -->
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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diff changeset
93 <param name="max" type="boolean" truevalue="--max" label="Turn all heuristic filters off (less speed, more power)" help="(--max)" falsevalue=""/>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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diff changeset
94 <param name="F1" type="float" label="Stage 1 (MSV) threshold: promote hits w/ P &lt;= F1" help="(--F1)" value="0.02"/>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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diff changeset
95 <param name="F2" type="float" label="Stage 2 (Vit) threshold: promote hits w/ P &lt;= F2" help="(--F2)" value="1e-3"/>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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diff changeset
96 <param name="F3" type="float" label="Stage 3 (Fwd) threshold: promote hits w/ P &lt;= F3" help="(--F3)" value="1e-5"/>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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97 <param name="nobias" type="boolean" truevalue="--nobias" label="Turn off composition bias filter" help="(--nobias)" falsevalue=""/>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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98 </xml>
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99 <token name="@EVAL_CALIB@">
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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100 --EmL $EmL
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101 --EmN $EmN
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102 --EvL $EvL
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iuc
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103 --EvN $EvN
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104 --EfL $EfL
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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105 --EfN $EfN
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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106 --Eft $Eft
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iuc
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107 </token>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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108 <xml name="eval_calib_xml">
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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109 <!-- Control of E-value calibration -->
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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110 <param name="EmL" type="integer" value="200" min="1" help="(--EmL)" label="Length of sequences for MSV Gumbel mu fit"/>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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diff changeset
111 <param name="EmN" type="integer" value="200" min="1" help="(--EmN)" label="Number of sequences for MSV Gumbel mu fit"/>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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diff changeset
112 <param name="EvL" type="integer" value="200" min="1" help="(--EvL)" label="Length of sequences for Viterbi Gumbel mu fit"/>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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113 <param name="EvN" type="integer" value="200" min="1" help="(--EvN)" label="Number of sequences for Viterbi Gumbel mu fit"/>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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114 <param name="EfL" type="integer" value="100" min="1" help="(--EfL)" label="Length of sequences for Forward exp tail tau fit"/>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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115 <param name="EfN" type="integer" value="200" min="1" help="(--EfN)" label="Number of sequences for Forward exp tail tau fit"/>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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116 <param name="Eft" type="float" value="0.04" min="0" max="1" help="(--Eft)" label="tail mass for Forward exponential tail tau fit"/>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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117 </xml>
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118 <token name="@OFORMAT_WITH_OPTS_NOPFAM@">
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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119 #if 'tblout' in str($oformat):
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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120 --tblout $tblout
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121 #end if
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122
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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123 #if 'domtblout' in str($oformat):
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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124 --domtblout $domtblout
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125 #end if
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126
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127 $acc $noali $notextw
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128 </token>
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129 <xml name="oformat_with_opts_nopfam">
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130 <!-- Options directing output -->
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131 <param name="oformat" multiple="True" display="checkboxes" label="Output Formats" type="select">
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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132 <option value="tblout" selected="true">Table of per-sequence hits (--tblout)</option>
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133 <option value="domtblout" selected="true">Table of per-domain hits (--domtblout)</option>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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134 </param>
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135 <param name="acc" type="boolean" truevalue="--acc" falsevalue="" label="Prefer accessions over names in output" help="(--acc)"/>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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136 <param name="noali" type="boolean" truevalue="--noali" falsevalue="" label="Don't output alignments, so output is smaller" help="(--noali)"/>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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137 <param name="notextw" type="boolean" truevalue="--notextw" falsevalue="" label="Unlimited ASCII text output line width" help="(--notextw)"/>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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138 </xml>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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139 <token name="@OFORMAT_WITH_OPTS@">
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140 #if 'tblout' in str($oformat):
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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141 --tblout $tblout
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142 #end if
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143
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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144 #if 'domtblout' in str($oformat):
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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145 --domtblout $domtblout
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146 #end if
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147
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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148 #if 'pfamtblout' in str($oformat):
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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149 --pfamtblout $pfamtblout
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150 #end if
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151
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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152 $acc $noali $notextw
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153 </token>
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154 <xml name="oformat_with_opts">
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155 <!-- Options directing output -->
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156 <param name="oformat" multiple="True" display="checkboxes" label="Output Formats" type="select">
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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157 <option value="tblout" selected="true">Table of per-sequence hits (--tblout)</option>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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158 <option value="domtblout" selected="true">Table of per-domain hits (--domtblout)</option>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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159 <option value="pfamtblout" selected="true">Table of hits and domains in Pfam format (--pfamtblout)</option>
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160 </param>
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161 <param name="acc" type="boolean" truevalue="--acc" falsevalue="" label="Prefer accessions over names in output" help="(--acc)"/>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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162 <param name="noali" type="boolean" truevalue="--noali" falsevalue="" label="Don't output alignments, so output is smaller" help="(--noali)"/>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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163 <param name="notextw" type="boolean" truevalue="--notextw" falsevalue="" label="Unlimited ASCII text output line width" help="(--notextw)"/>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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164 </xml>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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165 <xml name="oformat_test">
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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166 <param name="notextw" value="True" />
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167 </xml>
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168 <!-- TODO: tblout will match 'pfamtblout,dfamtblout' -->
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169 <token name="@OFORMAT_WITH_OPTS_N@">
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170 #if 'tblout' in str($oformat):
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171 --tblout $tblout
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172 #end if
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173
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174 #if 'dfamtblout' in str($oformat):
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175 --dfamtblout $dfamtblout
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176 #end if
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177
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178 #if 'aliscoresout' in str($oformat):
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179 --aliscoresout $aliscoresout
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180 #end if
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181
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182 $acc $noali $notextw
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183 </token>
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184 <xml name="oformat_with_opts_n">
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185 <!-- Options directing output -->
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186 <param name="oformat" multiple="True" display="checkboxes" label="Output Formats" type="select">
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187 <option value="tblout" selected="true">Table of hits (--tblout)</option>
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188 <option value="dfamtblout" selected="true">Table of hits in Dfam format (--dfamtblout)</option>
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189 <option value="aliscoresout">Scores for each position in each alignment to file (--aliscoresout)</option>
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190 </param>
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191 <param name="acc" type="boolean" truevalue="--acc" falsevalue="" label="Prefer accessions over names in output" help="(--acc)"/>
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192 <param name="noali" type="boolean" truevalue="--noali" falsevalue="" label="Don't output alignments, so output is smaller" help="(--noali)"/>
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193 <param name="notextw" type="boolean" truevalue="--notextw" falsevalue="" label="Unlimited ASCII text output line width" help="(--notextw)"/>
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194 </xml>
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195 <token name="@HSSI@">
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196 #if $hssi.hssi_select == "singlemx":
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197 --popen $hssi.popen
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198 --pextend $hssi.pextend
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199 #end if
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200 </token>
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201 <xml name="hssi">
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202 <!-- Handling single sequence inputs -->
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203 <conditional name="hssi">
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204 <param name="hssi_select" type="select" label="Options for handling single sequence inputs">
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205 <option value="false" selected="true">Disable</option>
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206 <option value="singlemx">Use substitution score matrix for single-sequence inputs</option>
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207 </param>
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208 <when value="singlemx">
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209 <param name="popen" type="float" value="0.02" label="Gap open probability" help="(--popen)" min="0.0" max="0.5"/>
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210 <param name="pextend" type="float" value="0.4" label="Gap extend probability" help="(--pextend)" min="0.0" max="1.0"/>
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211 </when>
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212 <when value="false">
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213 </when>
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214 <!-- -mx <s> : substitution score matrix (built-in matrices, with -singlemx)-->
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215 <!-- -mxfile <f> : read substitution score matrix from file <f> (with -singlemx)-->
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216 </conditional>
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217 </xml>
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218 <token name="@CPU@">
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219 --cpu \${GALAXY_SLOTS:-2}
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220 </token>
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221 <token name="@SEED@">
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222 --seed $seed
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223 </token>
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224 <xml name="seed">
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225 <param name="seed" label="RNG seed, 0 generates a random seed" value="42" type="integer" help="(--seed)" min="0"/>
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226 </xml>
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227 <xml name="seed_test">
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228 <param name="seed" value="4" />
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229 </xml>
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230 <token name="@ADV_OPTS@">
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231 $nonull2
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232
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233 #if $Z:
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234 -Z $Z
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235 #end if
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236
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237 #if $domZ:
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238 --domZ $domZ
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239 #end if
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240 </token>
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241 <xml name="adv_opts">
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242 <!-- Other options -->
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243 <param name="nonull2" type="boolean" truevalue="--nonull2" label="Turn off biased composition score corrections" help="(--nonull2)" falsevalue=""/>
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244 <param name="Z" type="integer" label="# of comparisons done for E-value calculation" help="(-Z)" optional="True"/>
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245 <param name="domZ" type="integer" label="# of significant sequences, for domain E-value calculation" help="(--domZ)" optional="True"/>
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246 </xml>
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247 <token name="@FORMAT_SELECTOR@">
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248 $input_format_select
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249 </token>
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250 <xml name="format_selector">
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251 <param name="input_format_select" type="select" label="Format of sequence and model">
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252 <option value="--amino">Protein</option>
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253 <option value="--dna">DNA</option>
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254 <option value="--rna">RNA</option>
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255 </param>
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256 </xml>
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257 <xml name="format_selector_noprot">
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258 <param name="input_format_select" type="select" label="Format of sequence and model">
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259 <option value="--dna">DNA</option>
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260 <option value="--rna">RNA</option>
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261 </param>
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262 </xml>
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263 <token name="@ARSWS@">
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264 $arsws.arsws_select
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265
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266 #if $arsws.arsws_select == "--wblosum":
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267 --wid $arsws.wid
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268 #end if
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269 </token>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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270 <xml name="arsws">
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271 <!-- Alternative relative sequence weighting strategies -->
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272 <conditional name="arsws">
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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273 <param name="arsws_select" type="select" label="Alternative relative sequence weighting strategies">
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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274 <option value="--wpb" selected="true">Henikoff position-based weights (--wpb)</option>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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275 <option value="--wgsc">Gerstein/Sonnhammer/Chothia tree weights (--wgsc)</option>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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276 <option value="--wblosum">Henikoff simple filter weights (--wblosum)</option>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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277 <option value="--wnone">don't do any relative weighting; set all to 1 (--wnnoe)</option>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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278 <option value="--wgiven">use weights as given in MSA file (--wgiven)</option>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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279 </param>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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diff changeset
280 <when value="--wpb">
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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281 </when>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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diff changeset
282 <when value="--wgsc">
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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diff changeset
283 </when>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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diff changeset
284 <when value="--wblosum">
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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285 <param name="wid" label="Set identity cutoff" value="0.62" type="float" help="(--wid)"/>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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286 </when>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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diff changeset
287 <when value="--wnone">
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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288 </when>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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289 <when value="--wgiven">
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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290 </when>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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291 </conditional>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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292 </xml>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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293 <token name="@AEEWS@">
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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294 #if $aeews.aeews_select != "":
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iuc
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295 --$aeews.aeews_select
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iuc
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296 #if $aeews.aeews_select == "eent":
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iuc
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297 --eset $aeews.eset
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iuc
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diff changeset
298 --ere $aeews.ere
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iuc
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299 --esigma $aeews.esigma
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300 #elif $aeews.aeews_select == "eclust":
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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301 --eset $aeews.eset
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iuc
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302 --eid $aeews.eid
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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303 #end if
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304 #end if
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iuc
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305 </token>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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306 <xml name="aeews">
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iuc
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307 <!-- Alternative effective sequence weighting strategies -->
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iuc
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diff changeset
308 <conditional name="aeews">
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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diff changeset
309 <param name="aeews_select" type="select" label="Alternative effective sequence weighting strategies">
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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310 <option value="">Disabled</option>
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iuc
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311 <option value="eent">Adjust eff seq # to achieve relative entropy target (--eent)</option>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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312 <option value="eclust">Eff seq # is the # of single linkage clusters (--eclust)</option>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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313 <option value="enone">No effective seq # weighting: just use nseq (--enone)</option>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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314 </param>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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diff changeset
315 <when value="">
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iuc
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316 </when>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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diff changeset
317 <when value="eent">
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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318 <param name="eset" type="float" value="0" label="set eff seq # for all models" help="(--eset)"/>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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319 <param name="ere" type="float" value="0" label="set minimum rel entropy/position" help="(--ere)"/>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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320 <param name="esigma" type="float" value="45" label="set sigma param" help="(--esigma)"/>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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321 </when>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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diff changeset
322 <when value="eclust">
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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323 <param name="eset" type="float" value="0" label="set eff seq # for all models" help="(--eset)"/>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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diff changeset
324 <param name="eid" type="float" value="0.62" label="set fractional identity cutoff" min="0" max="1" help="(--eid)"/>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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diff changeset
325 </when>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
326 <when value="enone">
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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diff changeset
327 </when>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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328 </conditional>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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329 </xml>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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330 <token name="@CUT@">
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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331 $cut_ga
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332 $cut_nc
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iuc
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333 $cut_tc
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334 </token>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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335 <xml name="cut">
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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336 <param name="cut_ga" type="boolean" truevalue="--cut_ga" label="use profile's GA gathering cutoffs to set all thresholding" help="(--cut_ga)" falsevalue=""/>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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337 <param name="cut_nc" type="boolean" truevalue="--cut_nc" label="use profile's NC gathering cutoffs to set all thresholding" help="(--cut_nc)" falsevalue=""/>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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338 <param name="cut_tc" type="boolean" truevalue="--cut_tc" label="use profile's TC gathering cutoffs to set all thresholding" help="(--cut_tc)" falsevalue=""/>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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339 </xml>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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diff changeset
340 <token name="@MCSS@">
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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diff changeset
341 --$mcs.model_construction_strategy_select
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iuc
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342
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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343 #if $mcs.model_construction_strategy_select == "fast":
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344 --symfrac $mcs.symfrac
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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345 #end if
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346
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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347 </token>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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348 <xml name="mcss">
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iuc
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349 <!-- Alternative model construction strategies -->
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iuc
parents:
diff changeset
350 <conditional name="mcs">
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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351 <param name="model_construction_strategy_select" type="select" label="Model Construction Strategy">
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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352 <option value="fast" selected="true">Assign columns with &gt;= symfrac residues as consensus (--fast)</option>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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353 <option value="hand">Manual construction (requires reference annotation) (--hand)</option>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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354 </param>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
355 <when value="fast">
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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356 <param name="symfrac" value="0.5" type="float" label="Sets sym fraction controlling --fast construction"/>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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357 </when>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
358 <when value="hand"></when>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
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359 </conditional>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
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diff changeset
360 <param name="fragthresh" label="Fraction of alignment length, under which sequences are excluded" help="HMMER infers fragments if the sequence length L is less than or equal to a fraction x times the alignment length in columns (--fragthresh)" value="0.5" optional="True" type="float" />
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
361
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
362 </xml>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
363 <token name="@PRIOR@">
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
364 $aps_select
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
365 </token>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
366 <xml name="prior">
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
367 <param name="aps_select" type="select" label="Alternative Prior Strategies">
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
368 <option value="" selected="true">Unspecified</option>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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diff changeset
369 <option value="--pnone">Don't use any prior; parameters are frequencies (--pnone)</option>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
370 <option value="--plaplace">Use a Laplace +1 prior (--plaplace)</option>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
371 </param>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
372 </xml>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
373 <xml name="citation">
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
374 <citations>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
375 <citation type="doi">10.1093/nar/gkr367</citation>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
376 </citations>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
377 </xml>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
378 <token name="@LENGTHS@">
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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diff changeset
379 #if $w_beta:
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
380 --w_beta $w_beta
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
381 #end if
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
382
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
383 #if $w_length:
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
384 --w_length $w_length
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
385 #end if
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
386
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
387 </token>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
388 <xml name="lengths">
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
389 <param name="w_beta" label="Tail mass at which window length is determined"
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
390 help="(--w_beta)" optional="True" type="float"/>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
391 <param name="w_length" label="Window Length"
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
392 help="(--w_length)" optional="True" type="integer" />
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
393 </xml>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
394 <xml name="input_hmm">
1
b5066aa77fea planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit f7d83adb11624763b9b113f938a1d5f311c8f9fa-dirty
iuc
parents: 0
diff changeset
395 <param name="hmmfile" type="data" label="HMM model" format="hmm2,hmm3"/>
0
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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diff changeset
396 </xml>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
397 <xml name="input_msa">
1
b5066aa77fea planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit f7d83adb11624763b9b113f938a1d5f311c8f9fa-dirty
iuc
parents: 0
diff changeset
398 <param name="msafile" type="data" label="Multiple Sequence Alignment" format="stockholm,clustal,fasta"
b5066aa77fea planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit f7d83adb11624763b9b113f938a1d5f311c8f9fa-dirty
iuc
parents: 0
diff changeset
399 help="in Stockholm, Clustal, or Fasta format. While this tool accepts fasta, please ensure that the sequences are not unaligned"/>
0
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
400 </xml>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
401
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
402
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
403 <token name="@ACCEL_HEUR_HELP@"><![CDATA[
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
404 Acceleration Heuristicts (--F1, --F2, --F3)
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
405 -------------------------------------------
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
406
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
407 **MSV filter**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
408
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
409 The sequence is aligned to the profile using a specialized model that
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
410 allows multiple high-scoring local ungapped segments to match. The
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
411 optimal alignment score (Viterbi score) is calculated under this multi-
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
412 segment model, hence the term MSV, for “multi-segment Viterbi”. This is
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
413 HMMER’s main speed heuristic. The MSV score is comparable to BLAST’s sum
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
414 score (optimal sum of ungapped alignment segments). Roughly speaking,
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
415 MSV is comparable to skipping the heuristic word hit and hit extension
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
416 steps of the BLAST acceleration algorithm.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
417
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
418 The MSV filter is very, very fast. In addition to avoiding indel
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
419 calculations in the dynamic programming table, it uses reduced precision
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
420 scores scaled to 8-bit integers, enabling acceleration via 16-way
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
421 parallel SIMD vector instructions.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
422
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
423 The MSV score is a true log-odds likelihood ratio, so it obeys
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
424 conjectures about the expected score distribution (Eddy, 2008) that
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
425 allow immediate and accurate calculation of the statistical significance
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
426 (P- value) of the MSV bit score.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
427
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
428 By default, comparisons with a P-value of ≤ 0.02 pass this filter,
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
429 meaning that about 2% of nonhomol- ogous sequences are expected to pass.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
430 You can use the --F1 option to change this threshold. For example, --F1
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
431 <0.05> would pass 5% of the comparisons, making a search more sensitive
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
432 but slower. Setting the threshold to ≥ 1.0 (--F1 99 for example) assures
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
433 that all comparisons will pass. Shutting off the MSV filter may be
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
434 worthwhile if you want to make sure you don’t miss comparisons that have
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
435 a lot of scattered insertions and deletions. Alternatively, the --max
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
436 option causes the MSV filter step (and all other filter steps) to be
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
437 bypassed.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
438
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
439 The MSV bit score is calculated as a log-odds score using the null model
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
440 for comparison. No correction for a biased composition or repetitive
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
441 sequence is done at this stage. For comparisons involving biased
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
442 sequences and/or profiles, more than 2% of comparisons will pass the MSV
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
443 filter. At the end of search output, there is a line like:
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
444
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
445 Passed MSV filter: 107917 (0.020272); expected 106468.8 (0.02)
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
446
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
447 which tells you how many and what fraction of comparisons passed the MSV
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
448 filter, versus how many (and what fraction) were expected.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
449
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
450 **Viterbi filter**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
451
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
452 The sequence is now aligned to the profile using a fast Viterbi algorithm for
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
453 optimal gapped alignment.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
454
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
455 This Viterbi implementation is specialized for speed. It is implemented in
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
456 8-way parallel SIMD vector instructions, using reduced precision scores that
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
457 have been scaled to 16-bit integers. Only one row of the dynamic programming
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
458 matrix is stored, so the routine only recovers the score, not the optimal
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
459 alignment itself. The reduced representation has limited range; local alignment
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
460 scores will not underflow, but high scoring comparisons can overflow and return
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
461 infinity, in which case they automatically pass the filter.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
462
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
463 The final Viterbi filter bit score is then computed using the appropriate null
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
464 model log likelihood (by default the biased composition filter model score, or
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
465 if the biased filter is off, just the null model score). If the P-value of this
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
466 score passes the Viterbi filter threshold, the sequence passes on to the next
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
467 step of the pipeline.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
468
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
469 The --F2 <x> option controls the P-value threshold for passing the Viterbi
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
470 filter score. The default is 0.001. The --max option bypasses all filters in
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
471 the pipeline. At the end of a search output, you will see a line like:
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
472
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
473 Passed Vit filter: 2207 (0.00443803); expected 497.3 (0.001)
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
474
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
475 which tells you how many and what fraction of comparisons passed the Viterbi
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
476 filter, versus how many were expected.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
477
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
478 **Forward filter/parser**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
479
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
480 The sequence is now aligned to the profile using the full Forward algorithm,
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
481 which calculates the likelihood of the target sequence given the profile,
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
482 summed over the ensemble of all possible alignments.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
483
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
484 This is a specialized time- and memory-efficient Forward implementation called
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
485 the “Forward parser”. It is implemented in 4-way parallel SIMD vector
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
486 instructions, in full precision (32-bit floating point). It stores just enough
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
487 information that, in combination with the results of the Backward parser
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
488 (below), posterior probabilities of start and stop points of alignments
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
489 (domains) can be calculated in the domain definition step (below), although the
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
490 detailed alignments themselves cannot be.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
491
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
492 The Forward filter bit score is calculated by correcting this score using the
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
493 appropriate null model log likelihood (by default the biased composition filter
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
494 model score, or if the biased filter is off, just the null model score). If the
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
495 P-value of this bit score passes the Forward filter threshold, the sequence
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
496 passes on to the next step of the pipeline.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
497
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
498 The bias filter score has no further effect in the pipeline. It is only used in
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
499 filter stages. It has no effect on final reported bit scores or P-values.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
500 Biased composition compensation for final bit scores is done by a more complex
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
501 domain-specific algorithm, described below.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
502
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
503 The --F3 <x> option controls the P-value threshold for passing the Forward
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
504 filter score. The default is 1e-5. The --max option bypasses all filters in the
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
505 pipeline. At the end of a search output, you will see a line like:
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
506
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
507 Passed Fwd filter: 1076 (0.00216371); expected 5.0 (1e-05)
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
508
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
509 which tells you how many and what fraction of comparisons passed the Forward
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
510 filter, versus how many were expected.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
511
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
512 **Bias Filter Options**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
513
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
514 The --max option bypasses all filters in the pipeline, including the bias
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
515 filter.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
516
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
517 The --nobias option turns off (bypasses) the biased composition filter. The
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
518 simple null model is used as a null hypothesis for MSV and in subsequent filter
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
519 steps. The biased composition filter step compromises a small amount of
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
520 sensitivity. Though it is good to have it on by default, you may want to shut
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
521 it off if you know you will have no problem with biased composition hits.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
522
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
523
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
524 **Advanced Documentation**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
525
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
526 A more detailed look at the internals of the various filter pipelines was
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
527 posted on the `developer's blog <http://selab.janelia.org/people/eddys/blog/?p=508>`__.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
528 The information posted there may be useful to those who are struggling with
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
529 poor-scoring sequences.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
530
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
531 ]]></token>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
532 <token name="@ADV_OPTS_HELP@"><![CDATA[
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
533 Advanced Options
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
534 ----------------
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
535
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
536 **nonull2**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
537
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
538 can be too aggressive sometimes, causing you to miss homologs. You can turn the
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
539 biased-composition score correction off with the --nonull2 option (and if
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
540 you’re doing that, you may also want to set --nobias, to turn off another
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
541 biased composition step called the bias filter, which affects which sequences
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
542 get scored at all).
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
543
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
544 **domZ**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
545
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
546 Assert that the total number of targets in your searches is <x>, for the
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
547 purposes of per-domain conditional E-value calculations, rather than the number
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
548 of targets that passed the reporting thresholds.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
549
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
550 **Z**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
551
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
552 Assert that the total number of targets in your searches is <x>, for the
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
553 purposes of per-sequence E-value calculations, rather than the actual number of
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
554 targets seen.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
555 ]]></token>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
556 <token name="@AEEWS_HELP@"><![CDATA[
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
557 Effective Sequence Number
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
558 -------------------------
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
559
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
560 After relative weights are determined, they are normalized to sum to a total
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
561 effective sequence number, eff nseq. This number may be the actual number of
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
562 sequences in the alignment, but it is almost always smaller than that. The
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
563 default entropy weighting method (--eent) reduces the effective sequence num-
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
564 ber to reduce the information content (relative entropy, or average expected
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
565 score on true homologs) per consensus position. The target relative entropy is
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
566 controlled by a two-parameter function, where the two parameters are settable
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
567 with --ere and --esigma.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
568
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
569 **--eent**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
570
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
571 Adjust effective sequence number to achieve a specific relative entropy per
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
572 position (see --ere). This is the default.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
573
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
574 **--eclust**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
575
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
576 Set effective sequence number to the number of single-linkage clusters at a
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
577 specific identity threshold (see --eid). This option is not recommended; it’s
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
578 for experiments evaluating how much better --eent is.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
579
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
580 **--enone**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
581
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
582 Turn off effective sequence number determination and just use the actual number
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
583 of sequences. One reason you might want to do this is to try to maximize the
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
584 relative entropy/position of your model, which may be useful for short models.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
585
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
586 **--eset**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
587
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
588 Explicitly set the effective sequence number for all models to <x>.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
589
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
590 **--ere**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
591
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
592 Set the minimum relative entropy/position target to <x>. Requires --eent. Default
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
593 depends on the sequence alphabet. For protein sequences, it is 0.59 bits/position;
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
594 for nucleotide sequences, it is 0.45 bits/position.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
595
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
596 **--esigma**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
597
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
598 Sets the minimum relative entropy contributed by an entire model alignment, over
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
599 its whole length. This has the effect of making short models have higher relative
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
600 entropy per position than --ere alone would give. The default is 45.0 bits.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
601
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
602 **--eid**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
603
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
604 Sets the fractional pairwise identity cutoff used by single linkage clustering
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
605 with the --eclust option. The default is 0.62.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
606 ]]></token>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
607 <token name="@ARSWS_HELP@"><![CDATA[
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
608 Options Controlling Relative Weights
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
609 ------------------------------------
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
610
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
611 HMMER uses an ad hoc sequence weighting algorithm to downweight closely related
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
612 sequences and up-weight distantly related ones. This has the effect of making
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
613 models less biased by uneven phylogenetic representation. For example, two
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
614 identical sequences would typically each receive half the weight that one
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
615 sequence would. These options control which algorithm gets used.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
616
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
617
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
618 **--wpb**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
619
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
620 Use the Henikoff position-based sequence weighting scheme [Henikoff and
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
621 Henikoff, J. Mol. Biol. 243:574, 1994]. This is the default.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
622
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
623 **--wgsc**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
624
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
625 Use the Gerstein/Sonnhammer/Chothia weighting algorithm [Gerstein et al, J.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
626 Mol. Biol. 235:1067, 1994].
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
627
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
628 **--wblosum**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
629
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
630 Use the same clustering scheme that was used to weight data in calculating
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
631 BLOSUM subsitution matrices [Henikoff and Henikoff, Proc. Natl. Acad. Sci
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
632 89:10915, 1992]. Sequences are single-linkage clustered at an identity
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
633 threshold (default 0.62; see --wid) and within each cluster of c sequences,
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
634 each sequence gets rela- tive weight 1/c.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
635
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
636 **--wnone**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
637
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
638 No relative weights. All sequences are assigned uniform weight.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
639
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
640 **--wid**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
641
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
642 Sets the identity threshold used by single-linkage clustering when using
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
643 --wblosum. Invalid with any other weighting scheme. Default is 0.62.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
644 ]]></token>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
645 <token name="@BIAS_COMP_HELP@"><![CDATA[
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
646 Bias Composition
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
647 ----------------
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
648
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
649 The next number, the bias, is a correction term for biased sequence composition
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
650 that has been applied to the sequence bit score.1 For instance, for the top hit
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
651 MYG PHYCA that scored 222.7 bits, the bias of 3.2 bits means that this sequence
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
652 originally scored 225.9 bits, which was adjusted by the slight 3.2 bit biased-
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
653 composition correction. The only time you really need to pay attention to the
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
654 bias value is when it’s large, on the same order of magnitude as the sequence
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
655 bit score. Sometimes (rarely) the bias correction isn’t aggressive enough, and
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
656 allows a non-homolog to retain too much score. Conversely, the bias correction
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
657 can be too aggressive sometimes, causing you to miss homologs. You can turn the
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
658 biased-composition score correction off with the --nonull2 option (and if
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
659 you’re doing that, you may also want to set --nobias, to turn off another
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
660 biased composition step called the bias filter, which affects which sequences
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
661 get scored at all).
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
662
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
663 ]]></token>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
664 <token name="@CUT_HELP@"><![CDATA[
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
665 Options for Model-specific Score Thresholding
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
666 ---------------------------------------------
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
667
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
668 Curated profile databases may define specific bit score thresholds for each
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
669 profile, superseding any thresholding based on statistical significance alone.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
670 To use these options, the profile must contain the appropriate (GA, TC, and/or
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
671 NC) optional score threshold annotation; this is picked up by hmmbuild from
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
672 Stockholm format alignment files. Each thresholding option has two scores: the
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
673 per-sequence threshold <x1> and the per-domain threshold <x2> These act as if
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
674 -T<x1> --incT<x1> --domT<x2> --incdomT<x2> has been applied specifically using
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
675 each model’s curated thresholds.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
676
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
677 **--cut_ga**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
678
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
679 Use the GA (gathering) bit scores in the model to set per-sequence (GA1) and
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
680 per-domain (GA2) reporting and inclusion thresholds. GA thresholds are
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
681 generally considered to be the reliable curated thresholds defining family
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
682 membership; for example, in Pfam, these thresholds define what gets included in
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
683 Pfam Full alignments based on searches with Pfam Seed models.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
684
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
685 **--cut_nc**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
686
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
687 Use the NC (noise cutoff) bit score thresholds in the model to set
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
688 per-sequence (NC1) and per-domain (NC2) reporting and inclusion thresholds. NC
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
689 thresholds are generally considered to be the score of the highest-scoring
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
690 known false positive.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
691
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
692 **--cut_tc**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
693
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
694 Use the NC (trusted cutoff) bit score thresholds in the model to set
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
695 per-sequence (TC1) and per-domain (TC2) reporting and inclusion thresholds. TC
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
696 thresholds are generally considered to be the score of the lowest-scoring known
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
697 true positive that is above all known false positives.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
698 ]]></token>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
699 <token name="@EVAL_CALIB_HELP@"><![CDATA[
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
700 Options Controlling H3 Parameter Estimation Methods
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
701 ---------------------------------------------------
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
702
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
703 H3 uses three short random sequence simulations to estimating the location
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
704 parameters for the expected score distributions for MSV scores, Viterbi scores,
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
705 and Forward scores. These options allow these simulations to be modified.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
706
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
707 **--EmL**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
708
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
709 Sets the sequence length in simulation that estimates the location parameter mu
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
710 for MSV E-values. Default is 200.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
711
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
712 **--EmN**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
713
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
714 Sets the number of sequences in simulation that estimates the location parameter
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
715 mu for MSV E-values. Default is 200.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
716
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
717 **--EvL**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
718
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
719 Sets the sequence length in simulation that estimates the location parameter mu
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
720 for Viterbi E-values. Default is 200.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
721
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
722 **--EvN**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
723
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
724 Sets the number of sequences in simulation that estimates the location parameter
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
725 mu for Viterbi E-values. Default is 200.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
726
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
727
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
728 **--EfL**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
729
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
730 Sets the sequence length in simulation that estimates the location parameter tau
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
731 for Forward E-values. Default is 100.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
732
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
733 **--EfN**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
734
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
735 Sets the number of sequences in simulation that estimates the location parameter
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
736 tau for Forward E-values. Default is 200.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
737
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
738 **--Eft**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
739
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
740 Sets the tail mass fraction to fit in the simulation that estimates the location param-
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
741 eter tau for Forward evalues. Default is 0.04.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
742 ]]></token>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
743 <token name="@FORMAT_SELECTOR_HELP@"><![CDATA[
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
744 Options for Specifying the Alphabet
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
745 -----------------------------------
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
746
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
747 The alphabet type (amino, DNA, or RNA) is autodetected by default, by looking
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
748 at the composition of the msafile. Autodetection is normally quite reliable,
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
749 but occasionally alphabet type may be ambiguous and autodetection can fail (for
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
750 instance, on tiny toy alignments of just a few residues). To avoid this, or to
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
751 increase robustness in automated analysis pipelines, you may specify the
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
752 alphabet type of msafile with these options.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
753 ]]></token>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
754 <token name="@HSSI_HELP@"><![CDATA[
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
755 Options Controlling Single Sequence Scoring (first Iteration)
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
756 -------------------------------------------------------------
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
757
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
758 By default, the first iteration uses a search model constructed from a single
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
759 query sequence. This model is constructed using a standard 20x20 substitution
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
760 matrix for residue probabilities, and two additional pa- rameters for
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
761 position-independent gap open and gap extend probabilities. These options allow
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
762 the default single-sequence scoring parameters to be changed.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
763
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
764 **Gap Open (--popen)**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
765
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
766 Set the gap open probability for a single sequence query model to <x>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
767
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
768 **Gap Extend (--pextend)**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
769
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
770 Set the gap extend probability for a single sequence query model to <x>.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
771
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
772
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
773 **--mx/--mxfile**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
774
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
775 These options are not currently supported
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
776 ]]></token>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
777 <token name="@LENGTHS_HELP@"><![CDATA[
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
778 Tail Mass Options
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
779 -----------------
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
780
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
781 **Window length tail mass (--w_beta)**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
782
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
783 The upper bound, W, on the length at which nhmmer expects to find an instance
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
784 of the model is set such that the fraction of all sequences generated by the
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
785 model with length >= W is less than <x>. The default is 1e-7.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
786
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
787
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
788 **Model instance length upper bound (--w length)**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
789
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
790 Override the model instance length upper bound, W, which is otherwise
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
791 controlled by --w beta. It should be larger than the model length. The value of
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
792 W is used deep in the acceleration pipeline, and modest changes are not
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
793 expected to impact results (though larger values of W do lead to longer run
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
794 time).
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
795
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
796 ]]></token>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
797 <token name="@MCSS_HELP@"><![CDATA[
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
798 **Options Controlling Profile Construction**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
799
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
800 These options control how consensus columns are defined in an alignment.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
801
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
802 **--fast**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
803
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
804 Define consensus columns as those that have a fraction >= symfrac of residues
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
805 as opposed to gaps. (See below for the --symfrac option.) This is the default.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
806
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
807 **--hand**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
808
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
809 Define consensus columns in next profile using reference annotation to the multiple
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
810 alignment. This allows you to define any consensus columns you like.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
811
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
812
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
813 **--symfrac**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
814
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
815 Define the residue fraction threshold necessary to define a consensus column
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
816 when using the --fast option. The default is 0.5. The symbol fraction in each
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
817 column is calculated after taking relative sequence weighting into account, and
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
818 ignoring gap characters corresponding to ends of sequence fragments (as opposed
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
819 to internal insertions/deletions). Setting this to 0.0 means that every
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
820 alignment column will be assigned as consensus, which may be useful in some
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
821 cases. Setting it to 1.0 means that only columns that include 0 gaps (internal
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
822 insertions/deletions) will be assigned as consensus.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
823
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
824 **--fragthresh**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
825
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
826 We only want to count terminal gaps as deletions if the aligned sequence is
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
827 known to be full-length, not if it is a fragment (for instance, because only
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
828 part of it was sequenced). HMMER uses a simple rule to infer fragments: if the
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
829 sequence length L is less than or equal to a fraction <x> times the alignment
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
830 length in columns, then the sequence is handled as a fragment. The default is
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
831 0.5. Setting --fragthresh0 will define no (nonempty) sequence as a fragment;
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
832 you might want to do this if you know you’ve got a carefully curated alignment
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
833 of full-length sequences. Setting --fragthresh1 will define all sequences as
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
834 fragments; you might want to do this if you know your alignment is entirely
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
835 composed of fragments, such as translated short reads in metagenomic shotgun
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
836 data.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
837
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
838 ]]></token>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
839 <token name="@OFORMAT_WITH_OPTS_HELP@"><![CDATA[
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
840 Options for Controlling Output
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
841 ------------------------------
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
842
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
843 **Table of hits**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
844
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
845 Save a simple tabular (space-delimited) file summarizing the per-target output, with
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
846 one data line per homologous target model found.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
847
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
848 **Table of per-domain hits**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
849
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
850 Save a simple tabular (space-delimited) file summarizing the per-domain output,
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
851 with one data line per homologous domain detected in a query sequence for each
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
852 homologous model.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
853
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
854 **Table of hits and domains in Pfam Format**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
855
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
856 Save an especially succinct tabular (space-delimited) file summarizing the
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
857 per-target output, with one data line per homologous target model found.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
858 ]]></token>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
859 <token name="@OFORMAT_WITH_OPTS_NOPFAM_HELP@"><![CDATA[
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
860 Options for Controlling Output
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
861 ------------------------------
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
862
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
863 **Table of hits**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
864
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
865 Save a simple tabular (space-delimited) file summarizing the per-target output, with
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
866 one data line per homologous target model found.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
867
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
868 **Table of per-domain hits**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
869
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
870 Save a simple tabular (space-delimited) file summarizing the per-domain output,
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
871 with one data line per homologous domain detected in a query sequence for each
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
872 homologous model.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
873 ]]></token>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
874 <token name="@OFORMAT_WITH_OPTS_N_HELP@"><![CDATA[
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
875 Options for Controlling Output
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
876 ------------------------------
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
877
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
878 **Table of hits**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
879
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
880 Save a simple tabular (space-delimited) file summarizing the per-target output, with
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
881 one data line per homologous target model found.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
882
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
883 **Table of hits (dfam)**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
884
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
885 Save a tabular (space-delimited) file summarizing the per-hit output, similar
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
886 to --tblout but more succinct.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
887
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
888
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
889 **List of per-position scores for each hit (--aliscoreout)**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
890
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
891 Save to file a list of per-position scores for each hit. This is useful, for
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
892 example, in identifying regions of high score density for use in resolving
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
893 overlapping hits from different models.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
894
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
895 ]]></token>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
896 <token name="@PRIOR_HELP@"><![CDATA[
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
897 Options Controlling Priors
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
898 --------------------------
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
899
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
900 By default, weighted counts are converted to mean posterior probability
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
901 parameter estimates using mixture Dirichlet priors. Default mixture Dirichlet
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
902 prior parameters for protein models and for nucleic acid (RNA and DNA) models
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
903 are built in. The following options allow you to override the default priors.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
904
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
905 **No priors (--pnone)**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
906
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
907 Don’t use any priors. Probability parameters will simply be the observed
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
908 frequencies, after relative sequence weighting.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
909
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
910 **Laplace +1 prior**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
911
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
912 Use a Laplace +1 prior in place of the default mixture Dirichlet prior.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
913 ]]></token>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
914 <token name="@SEED_HELP@"><![CDATA[
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
915 Random Seeding
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
916 --------------
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
917
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
918 Seed the random number generator with <n>, an integer >= 0. If <n> is nonzero,
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
919 any stochastic simulations will be reproducible; the same command will give the
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
920 same results. If <n> is 0, the random number generator is seeded arbitrarily,
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
921 and stochastic simulations will vary from run to run of the same command.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
922
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
923 ]]></token>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
924 <token name="@THRESHOLDS_HELP@"><![CDATA[
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
925 Options for Reporting Thresholds
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
926 --------------------------------
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
927
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
928 Reporting thresholds control which hits are reported in output files (the main
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
929 output, --tblout, and --domtblout).
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
930
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
931 **E-value (-E)**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
932
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
933 In the per-target output, report target profiles with an E-value of <= <x>. The
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
934 default is 10.0, meaning that on average, about 10 false positives will be
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
935 reported per query, so you can see the top of the noise and decide for yourself
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
936 if it’s really noise.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
937
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
938 **Bit score (-T)**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
939
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
940 Instead of thresholding per-profile output on E-value, instead report target profiles
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
941 with a bit score of >= <x>.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
942
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
943 **domain E-value (--domE)**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
944
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
945 In the per-domain output, for target profiles that have already satisfied the
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
946 per-profile reporting threshold, report individual domains with a conditional
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
947 E-value of <= <x>. The default is 10.0. A conditional E-value means the
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
948 expected number of additional false positive domains in the smaller search
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
949 space of those comparisons that already satisfied the per-profile reporting
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
950 threshold (and thus must have at least one homologous domain already).
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
951
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
952 **domain Bit scores (--domT)**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
953
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
954 Instead of thresholding per-domain output on E-value, instead report domains
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
955 with a bit score of >= <x>.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
956
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
957 Options for Inclusion Thresholds
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
958 --------------------------------
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
959
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
960 Inclusion thresholds are stricter than reporting thresholds. Inclusion
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
961 thresholds control which hits are considered to be reliable enough to be
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
962 included in an output alignment or a subsequent search round. In hmmscan, which
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
963 does not have any alignment output (like hmmsearch or phmmer) nor any iterative
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
964 search steps (like jackhmmer), inclusion thresholds have little effect. They
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
965 only affect what domains get marked as significant (!) or questionable (?) in
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
966 domain output.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
967
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
968 **E-value of per target inclusion threshold**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
969
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
970 Use an E-value of <= <x> as the per-target inclusion threshold. The default is
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
971 0.01, meaning that on average, about 1 false positive would be expected in
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
972 every 100 searches with different query sequences.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
973
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
974 **Bit score of per target inclusion threshold**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
975
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
976 Instead of using E-values for setting the inclusion threshold, instead use a
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
977 bit score of >= <x> as the per-target inclusion threshold. It would be unusual
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
978 to use bit score thresholds with hmmscan, because you don’t expect a single
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
979 score threshold to work for different profiles; different profiles have
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
980 slightly different expected score distributions.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
981
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
982 **domain E-value per target inclusion treshold**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
983
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
984 Use a conditional E-value of <= <x> as the per-domain inclusion threshold, in
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
985 targets that have already satisfied the overall per-target inclusion threshold.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
986
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
987 **domain Bit score per target inclusion treshold**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
988
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
989 Instead of using E-values, instead use a bit score of >= <x> as the per-domain
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
990 inclusion threshold. As with --incT above, it would be unusual to use a single
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
991 bit score threshold in hmmscan.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
992
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
993 ]]></token>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
994 <token name="@THRESHOLDS_NODOM_HELP@"><![CDATA[
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
995 Options for Reporting Thresholds
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
996 --------------------------------
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
997
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
998 Reporting thresholds control which hits are reported in output files (the main
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
999 output, --tblout, and --domtblout).
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1000
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1001 **E-value (-E)**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1002
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1003 In the per-target output, report target profiles with an E-value of <= <x>. The
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1004 default is 10.0, meaning that on average, about 10 false positives will be
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1005 reported per query, so you can see the top of the noise and decide for yourself
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1006 if it’s really noise.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1007
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1008 **Bit score (-T)**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1009
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1010 Instead of thresholding per-profile output on E-value, instead report target profiles
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1011 with a bit score of >= <x>.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
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1012
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1013 Options for Inclusion Thresholds
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1014 --------------------------------
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1015
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1016 Inclusion thresholds are stricter than reporting thresholds. Inclusion
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1017 thresholds control which hits are considered to be reliable enough to be
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1018 included in an output alignment or a subsequent search round. In hmmscan, which
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1019 does not have any alignment output (like hmmsearch or phmmer) nor any iterative
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1020 search steps (like jackhmmer), inclusion thresholds have little effect. They
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1021 only affect what domains get marked as significant (!) or questionable (?) in
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1022 domain output.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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diff changeset
1023
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1024 **E-value of per target inclusion threshold**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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diff changeset
1025
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1026 Use an E-value of <= <x> as the per-target inclusion threshold. The default is
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1027 0.01, meaning that on average, about 1 false positive would be expected in
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1028 every 100 searches with different query sequences.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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diff changeset
1029
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1030 **Bit score of per target inclusion threshold**
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1031
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1032 Instead of using E-values for setting the inclusion threshold, instead use a
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1033 bit score of >= <x> as the per-target inclusion threshold. It would be unusual
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1034 to use bit score thresholds with hmmscan, because you don’t expect a single
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1035 score threshold to work for different profiles; different profiles have
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1036 slightly different expected score distributions.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1037
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1038 ]]></token>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1039 <token name="@ATTRIBUTION@"><![CDATA[
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1040
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1041 Attribution
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1042 -----------
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1043
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1044 This Galaxy tool relies on HMMER3_ from http://hmmer.janelia.org/
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1045 Internally the software is cited as:
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1046
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1047 ::
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1048
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1049 # hmmscan :: search sequence(s) against a profile database
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1050 # HMMER 3.1 (February 2013); http://hmmer.org/
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1051 # Copyright (C) 2011 Howard Hughes Medical Institute.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1052 # Freely distributed under the GNU General Public License (GPLv3).
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1053 # - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1054
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1055 The wrappers were written by Eric Rasche and is licensed under Apache2_. The
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1056 documentation is copied from the HMMER3 documentation.
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1057
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1058 .. _Apache2: http://www.apache.org/licenses/LICENSE-2.0
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1059 .. _HMMER3: http://hmmer.janelia.org/
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1060
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1061
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1062 ]]></token>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1063 <token name="@HELP_PRE@"><![CDATA[
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1064
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1065 What it does
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1066 ============
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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diff changeset
1067 ]]></token>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1068 <token name="@HELP_PRE_OTH@"><![CDATA[
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1069 Options
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
parents:
diff changeset
1070 =======
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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1071 ]]></token>
62479bdcc059 planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/hmmer3 commit 4164b44c651bcbdac6637eccce61b2a802c9b569
iuc
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1072 </macros>