Mercurial > repos > iuc > medaka_variant
changeset 3:e86fcef8ed91 draft
"planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/medaka commit e80b649094384fc6d7a8f917300db3550cc99a44"
| author | iuc |
|---|---|
| date | Tue, 01 Sep 2020 03:08:24 -0400 |
| parents | d50c1d5b72ce |
| children | 2308bc523659 |
| files | annotateVCF.py macros.xml test-data/annotate_vcf_test.pileup test-data/annotate_vcf_test.vcf test-data/annotated.vcf test-data/basecalls.fastq test-data/bwa-mem-mt-genome.fa.fai test-data/medaka_test.bam test-data/medaka_test.bam.bai test-data/medaka_test.hdf test-data/ref.fasta test-data/ref.fasta.fai test-data/variants.vcf.gz variant.xml |
| diffstat | 14 files changed, 482 insertions(+), 549 deletions(-) [+] |
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--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/annotateVCF.py Tue Sep 01 03:08:24 2020 -0400 @@ -0,0 +1,398 @@ +#!/usr/bin/env python3 + +# Takes in VCF file and a samtools mpileup output file +# Fills in annotation for the VCF file including AF, DP +# SB, and DP4 +# +# Usage statement: +# python annotateVCF.py in_vcf.vcf in_mpileup.txt out_vcf.vcf +# +# Can generate in_mileup.txt with samtools mpileup (and can restrict which sites to generate pileups for with in_vcf.vcf) + +# 08/24/2020 - Nathan P. Roach, natproach@gmail.com + +import sys +from math import isnan, log10 + +from scipy.stats import fisher_exact + + +def pval_to_phredqual(pval): + return int(round(-10. * log10(pval))) + + +def parseSimpleSNPpileup(fields, ref_base, alt_base): + base_to_idx = { + 'A': 0, + 'a': 0, + 'T': 1, + 't': 1, + 'C': 2, + 'c': 2, + 'G': 3, + 'g': 3 + } + + base_to_idx_stranded = { + 'A': 0, + 'T': 1, + 'C': 2, + 'G': 3, + 'a': 4, + 't': 5, + 'c': 6, + 'g': 7 + } + ref_base2 = fields[2] + counts = [0, 0, 0, 0] + stranded_counts = [0, 0, 0, 0, 0, 0, 0, 0] + ref_idx = base_to_idx[fields[2]] + dp = int(fields[3]) + carrot_flag = False + ins_flag = False + ins_str = "" + ins_len = 0 + insertion = "" + del_flag = False + del_str = "" + del_len = 0 + deletion = "" + # dollar_flag = False + for base in fields[4]: + if carrot_flag: + carrot_flag = False + continue + if ins_len > 0: + insertion += base + ins_len -= 1 + continue + if del_len > 0: + deletion += base + del_len -= 1 + continue + if ins_flag: + if base.isdigit(): + ins_str += base + else: + ins_len = int(ins_str) - 1 + insertion = base + ins_flag = False + elif del_flag: + if base.isdigit(): + del_str += base + else: + del_len = int(del_str) - 1 + deletion = base + del_flag = False + else: + if base == '^': + carrot_flag = True + continue + elif base == '$': + continue + elif base == '+': + ins_flag = True + elif base == '-': + del_flag = True + elif base == '.': + counts[ref_idx] += 1 + stranded_counts[base_to_idx_stranded[ref_base2]] += 1 + elif base == ',': + counts[ref_idx] += 1 + stranded_counts[base_to_idx_stranded[ref_base2.lower()]] += 1 + elif base == 'N' or base == 'n': + continue + elif base == '*': + continue + else: + counts[base_to_idx[base]] += 1 + stranded_counts[base_to_idx_stranded[base]] += 1 + af = float(counts[base_to_idx[alt_base]]) / float(sum(counts)) + if float(sum(stranded_counts[0:4])) == 0: + faf = float("nan") + else: + faf = float(stranded_counts[base_to_idx_stranded[alt_base]]) / float(sum(stranded_counts[0:4])) + if float(sum(stranded_counts[4:])) == 0: + raf = float("nan") + else: + raf = float(stranded_counts[base_to_idx_stranded[alt_base.lower()]]) / float(sum(stranded_counts[4:])) + dp4 = [stranded_counts[base_to_idx_stranded[ref_base]], + stranded_counts[base_to_idx_stranded[ref_base.lower()]], + stranded_counts[base_to_idx_stranded[alt_base]], + stranded_counts[base_to_idx_stranded[alt_base.lower()]]] + return (dp, af, faf, raf, dp4) + + +def parseIndelPileup(fields, ref_base, alt_base): + counts = [0, 0, 0, 0, 0, 0, 0, 0, 0] # indel ref match, indel fwd ref match, indel rev ref match, indel alt match, indel fwd alt match, indel rev alt match, other, other fwd, other rev + ref_base2 = fields[2] + + carrot_flag = False + ins_flag = False + ins_str = "" + ins_len = 0 + del_flag = False + del_str = "" + del_len = 0 + first_iter = True + forward_flag = False + last_seq = "" + last_seq_code = 'b' + for base in fields[4]: + if ins_flag: + if base.isdigit(): + ins_str += base + else: + ins_len = int(ins_str) + ins_flag = False + if del_flag: + if base.isdigit(): + del_str += base + else: + del_len = int(del_str) + del_flag = False + if ins_len > 0: + last_seq += base + last_seq_code = 'i' + ins_len -= 1 + continue + if del_len > 0: + last_seq += base + last_seq_code = 'd' + del_len -= 1 + continue + if carrot_flag: + carrot_flag = False + continue + if base == '.' or base == ','\ + or base == 'A' or base == 'a'\ + or base == 'C' or base == 'c'\ + or base == 'G' or base == 'g'\ + or base == 'T' or base == 't'\ + or base == 'N' or base == 'n'\ + or base == '>' or base == '<'\ + or base == '*' or base == '#': + if first_iter: + first_iter = False + else: + if last_seq_code == 'i': + if last_seq.upper() == alt_base.upper(): + counts[3] += 1 + if forward_flag: + counts[4] += 1 + else: + counts[5] += 1 + else: + counts[6] += 1 + if forward_flag: + counts[7] += 1 + else: + counts[8] += 1 + elif last_seq_code == 'd': + if last_seq.upper() == ref_base.upper(): + counts[3] += 1 + if forward_flag: + counts[4] += 1 + else: + counts[5] += 1 + else: + counts[6] += 1 + if forward_flag: + counts[7] += 1 + else: + counts[8] += 1 + elif last_seq_code == 'b': + if last_seq.upper() == ref_base.upper(): + counts[0] += 1 + if forward_flag: + counts[1] += 1 + else: + counts[2] += 1 + elif last_seq.upper() == alt_base.upper(): + counts[3] += 1 + if forward_flag: + counts[4] += 1 + else: + counts[5] += 1 + else: + counts[6] += 1 + if forward_flag: + counts[7] += 1 + else: + counts[8] += 1 + if base == '.': + last_seq = ref_base2 + forward_flag = True + last_seq_code = 'b' + elif base == ',': + last_seq = ref_base2 + forward_flag = False + last_seq_code = 'b' + elif base == '>' or base == '<' or base == '*' or base == '#': + continue + else: + forward_flag = base.isupper() + last_seq = base.upper() + last_seq_code = 'b' + elif base == '+': + ins_flag = True + ins_str = "" + elif base == '-': + del_flag = True + del_str = "" + elif base == '^': + carrot_flag = True + elif base == '$': + continue + if first_iter: + first_iter = False + + if last_seq_code == 'i': + if last_seq.upper() == alt_base.upper(): + counts[3] += 1 + if forward_flag: + counts[4] += 1 + else: + counts[5] += 1 + else: + counts[6] += 1 + if forward_flag: + counts[7] += 1 + else: + counts[8] += 1 + elif last_seq_code == 'd': + if last_seq.upper() == ref_base.upper(): + counts[3] += 1 + if forward_flag: + counts[4] += 1 + else: + counts[5] += 1 + else: + counts[6] += 1 + if forward_flag: + counts[7] += 1 + else: + counts[8] += 1 + elif last_seq_code == 'b': + if last_seq.upper() == ref_base.upper(): + counts[0] += 1 + if forward_flag: + counts[1] += 1 + else: + counts[2] += 1 + elif last_seq.upper() == alt_base.upper(): + counts[3] += 1 + if forward_flag: + counts[4] += 1 + else: + counts[5] += 1 + else: + counts[6] += 1 + if forward_flag: + counts[7] += 1 + else: + counts[8] += 1 + dp = int(fields[3]) + af = float(counts[3]) / float(sum([counts[0], counts[3], counts[6]])) + if sum([counts[1], counts[4], counts[7]]) == 0: + faf = float("nan") + else: + faf = float(counts[4]) / float(sum([counts[1], counts[4], counts[7]])) + if sum([counts[2], counts[5], counts[8]]) == 0: + raf = float("nan") + else: + raf = float(counts[5]) / float(sum([counts[2], counts[5], counts[8]])) + dp4 = [counts[1], counts[2], counts[4], counts[5]] + return (dp, af, faf, raf, dp4) + + +def annotateVCF(in_vcf_filepath, in_mpileup_filepath, out_vcf_filepath): + in_vcf = open(in_vcf_filepath, 'r') + in_mpileup = open(in_mpileup_filepath, 'r') + out_vcf = open(out_vcf_filepath, 'w') + + # First pass parsing of input vcf, output headerlines + new headerlines, add VCF sites we care about to to_examine (limits memory usage for sites that don't need annotation) + to_examine = {} + for line in in_vcf: + if line[0:2] == "##": + out_vcf.write(line) + elif line[0] == "#": + out_vcf.write("##annotateVCFVersion=0.1\n") + out_vcf.write("##INFO=<ID=DP,Number=1,Type=Integer,Description=\"Raw Depth\">\n") + out_vcf.write("##INFO=<ID=AF,Number=1,Type=Float,Description=\"Allele Frequency\">\n") + out_vcf.write("##INFO=<ID=FAF,Number=1,Type=Float,Description=\"Forward Allele Frequency\">\n") + out_vcf.write("##INFO=<ID=RAF,Number=1,Type=Float,Description=\"Reverse Allele Frequency\">\n") + out_vcf.write("##INFO=<ID=SB,Number=1,Type=Integer,Description=\"Phred-scaled strand bias at this position\">\n") + out_vcf.write("##INFO=<ID=DP4,Number=4,Type=Integer,Description=\"Counts for ref-forward bases, ref-reverse, alt-forward and alt-reverse bases\">\n") + out_vcf.write(line) + else: + fields = line.strip().split() + if fields[0] in to_examine: + to_examine[fields[0]][int(fields[1])] = (fields[3], fields[4]) + else: + to_examine[fields[0]] = {int(fields[1]): (fields[3], fields[4])} + in_vcf.close() + data = {} + + # Populate data dictionary, which relates chromosome and position to the following: + # depth of coverage + # allele frequency + # forward strand allele frequency + # reverse strand allele frequency + # dp4 - depth of coverage of ref allele fwd strand, DOC of ref allele rev strand, DOC of alt allele fwd strand, DOC of alt allele rev strand + for line in in_mpileup: + fields = line.strip().split() + if fields[0] not in to_examine: + continue + if int(fields[1]) not in to_examine[fields[0]]: + continue + (ref_base, alt_base) = to_examine[fields[0]][int(fields[1])] + if len(ref_base.split(',')) > 1: # Can't handle multiple ref alleles + continue + if len(alt_base.split(',')) > 1: # Can't handle multiple alt alleles + continue + if len(ref_base) > 1 or len(alt_base) > 1: + if len(ref_base) > 1 and len(alt_base) > 1: # Can't handle complex indels + continue + data[(fields[0], int(fields[1]))] = parseIndelPileup(fields, ref_base, alt_base) + if len(ref_base) == 1 and len(alt_base) == 1: + data[(fields[0], int(fields[1]))] = parseSimpleSNPpileup(fields, ref_base, alt_base) + in_mpileup.close() + # Reopen vcf, this time, skip header, annotate all the sites for which there is an entry in data dictionary + # (Sites without entries have either multiple ref or alt bases, or have complex indels. Not supported (for now), and not reported as a result) + in_vcf = open(in_vcf_filepath, 'r') + for line in in_vcf: + if line[0] == '#': + continue + fields = line.strip().split('\t') + if (fields[0], int(fields[1])) not in data: + continue + (dp, af, faf, raf, dp4) = data[(fields[0], int(fields[1]))] + dp2x2 = [[dp4[0], dp4[1]], [dp4[2], dp4[3]]] + _, p_val = fisher_exact(dp2x2) + sb = pval_to_phredqual(p_val) + if fields[7] == "": + info = [] + else: + info = fields[7].split(';') + info.append("DP=%d" % (dp)) + info.append("AF=%.6f" % (af)) + if isnan(faf): + info.append("FAF=NaN") + else: + info.append("FAF=%.6f" % (faf)) + if isnan(raf): + info.append("RAF=NaN") + else: + info.append("RAF=%.6f" % (raf)) + info.append("SB=%d" % (sb)) + info.append("DP4=%s" % (','.join([str(x) for x in dp4]))) + new_info = ';'.join(info) + fields[7] = new_info + out_vcf.write("%s\n" % ("\t".join(fields))) + in_vcf.close() + out_vcf.close() + + +if __name__ == "__main__": + annotateVCF(sys.argv[1], sys.argv[2], sys.argv[3])
--- a/macros.xml Thu Jun 18 05:08:21 2020 -0400 +++ b/macros.xml Tue Sep 01 03:08:24 2020 -0400 @@ -5,6 +5,7 @@ <xml name="requirements"> <requirements> <requirement type="package" version="@TOOL_VERSION@">medaka</requirement> + <requirement type="package" version="1.4.1">scipy</requirement> </requirements> </xml> <xml name="version_command">
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/annotate_vcf_test.pileup Tue Sep 01 03:08:24 2020 -0400 @@ -0,0 +1,3 @@ +NC_045512.2 45 G 31 CCCCACCCCCCccccccccc,ccCCC*,+3ttccCC ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ +NC_045512.2 685 A 75 .-9AAGTCATTT,-9aagtcattt,-9aagtcattt*.-9AAGTCATTT*G.-9AAGTCATTT.-9AAGTCATTT,-9aagtcattt*,-9aagtcattt,-9aagtcattt,-9aagtcattt,-9aagtcattt,,-9aagtcattt,-9aagtcattt,-9aagtcatttG.-9AAGTCATTT*,-9aagtcatttG.-9AAGTCATTT.-9AAGTCATTTG.-9AAGTCATTTG.-9AAGTCATTT.-9AAGTCATTT.-9AAGTCATTT.-9AAGTCATTT.-9AAGTCATTT*.-9AAGTCATTT*.-9AAGTCATTT.-9AAGTCATTT.-9AAGTCATTT.-9AAGTCATTT.-9AAGTCATTTG.-9AAGTCATTT.-9AAGTCATTT.-9AAGTCATTT.-9AAGTCATTT.-9AAGTCATTT.-9AAGTCATTT*,-9aagtcattt,-9aagtcattt*,-9aagtcattt,-9aagtcattt,-9aagtcattt,-9aagtcattt,-9aagtcattt,-9aagtcattt*,-4aagt,-9aagtcattt,-9aagtcattt**G,-9aagtcattt,-9aagtcattt,-9aagtcatttG,-9aagtcattt,-9aagtcattt*,-9aagtcattt* ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ +NC_045512.2 1813 T 51 ..-3AAA..-2AA..-1A*.-1A.-3AAA*..-1A..-1A.-2AA.-1A.-3AAA.-2AA.-2AA.-3AAA.,-1a,-1a,-6aaaaaa,,,-1a,,-2aa,-2aa,,-1a,-1a,*,-1a,-1a,+1a,-2aa,-1a,+1a,-1a,,-2aa.-3AAA,-1a.-2AA,-1a*,-2aa,-2aa ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/annotate_vcf_test.vcf Tue Sep 01 03:08:24 2020 -0400 @@ -0,0 +1,9 @@ +##fileformat=VCFv4.1 +##medaka_version=1.0.3 +##contig=<ID=NC_045512.2> +##FORMAT=<ID=GT,Number=1,Type=String,Description="Medaka genotype."> +##FORMAT=<ID=GQ,Number=1,Type=Integer,Description="Medaka genotype quality score"> +#CHROM POS ID REF ALT QUAL FILTER INFO FORMAT SAMPLE +NC_045512.2 45 . G C 46.359 PASS GT:GQ 1:46 +NC_045512.2 685 . AAAGTCATTT A 260.487 PASS GT:GQ 1:260 +NC_045512.2 1813 . TA T 11.034 PASS GT:GQ 1:11
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/annotated.vcf Tue Sep 01 03:08:24 2020 -0400 @@ -0,0 +1,16 @@ +##fileformat=VCFv4.1 +##medaka_version=1.0.3 +##contig=<ID=NC_045512.2> +##FORMAT=<ID=GT,Number=1,Type=String,Description="Medaka genotype."> +##FORMAT=<ID=GQ,Number=1,Type=Integer,Description="Medaka genotype quality score"> +##annotateVCFVersion=0.1 +##INFO=<ID=DP,Number=1,Type=Integer,Description="Raw Depth"> +##INFO=<ID=AF,Number=1,Type=Float,Description="Allele Frequency"> +##INFO=<ID=FAF,Number=1,Type=Float,Description="Forward Allele Frequency"> +##INFO=<ID=RAF,Number=1,Type=Float,Description="Reverse Allele Frequency"> +##INFO=<ID=SB,Number=1,Type=Integer,Description="Phred-scaled strand bias at this position"> +##INFO=<ID=DP4,Number=4,Type=Integer,Description="Counts for ref-forward bases, ref-reverse, alt-forward and alt-reverse bases"> +#CHROM POS ID REF ALT QUAL FILTER INFO FORMAT SAMPLE +NC_045512.2 45 . G C 46.359 PASS DP=31;AF=0.900000;FAF=0.937500;RAF=0.857143;SB=6;DP4=0,2,15,12 GT:GQ 1:46 +NC_045512.2 685 . AAAGTCATTT A 260.487 PASS DP=75;AF=0.880000;FAF=0.789474;RAF=0.972973;SB=0;DP4=0,0,30,36 GT:GQ 1:260 +NC_045512.2 1813 . TA T 11.034 PASS DP=51;AF=0.607843;FAF=0.521739;RAF=0.678571;SB=0;DP4=0,0,12,19 GT:GQ 1:11
--- a/test-data/basecalls.fastq Thu Jun 18 05:08:21 2020 -0400 +++ b/test-data/basecalls.fastq Tue Sep 01 03:08:24 2020 -0400 @@ -498,519 +498,3 @@ GTTGTACTTCGTTCGGTTACGTATTGCTGCGCGCGCACTCTCTGTCGTCAACGGCGTCAGATATTATTATAAGAGACAGCTCCTTCACCAAGCATTGATATTTCATTTAATTCGCCAGTCCTATATAAAAAAAATCTCTTTGTTTGATCTGTTGCTATTATTGCAATATCGTTAATTCTATTATCTATTCTTTTTAGGTTACCTATTATTTCATCTTTTCTTTTTGTGTTAGTAGTTTTGATACGTTTTATCGTTGCTTCTTCATTTATGTTTCTTGATGTGGTTATTATCGCTTGCGGTTTTGAATTCATATAGCTTACCTTTTTTAGTTTGTTTTATTTCTCCGTTTATTTCTTGTGCTTTTTTGTGTTATTTTTATAGTAATCAATTCTTCTGGGGGTTCTTTTTCCGTTCTGTGTTTCACTAACCTTAATCATTTAAAACATTTCCCCCCTTTCCTGAGAGCCGAGGGGTTTGTCGCAATGGAGGGTGTTTGATAATATTGACTCAACATTGGGGGACACGCTTGATTCTGTCTCTTATATACAATCTCCGAGCCCACGAGACCAGAGTGCGCGCAGCAATGCGTAACT + 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-CAGTGTACTTCGTTCGTTGTATTCTGCGCACGCACTCTCTGTCGTCGGCGTCAGATCGTATAAGAGACAGGCACAGAGATAGCGCTCAGGACGGATGCCGAACGGCTGAAAAGCAGAGCGTGGAGAAAATGCCGCCAAGGCGTCTTCGCTTCTCTAACTCACTGCAAACTAACTGCATCGGTCGTTCGACTGCGGCAGAGGAAGCGGTGTCAGCTCACTCAAAAGCGGTAATACGATTATCCACAGAATCGGGGATAAAGTCGGAAAGAACATGTGAGCAAAAAGCAAAGCACCCGGAGGAGAAGCCAGCGCCGCAGGTTACCGCTGACTCCGCCTGACGAGCATCACAAAAATCGACGCGCTCAAGCCAGAGGTGGCGAAACCCGACAGGACTATAAAGGCTTGGTGTTTCCCCTGGAAGCTCCCTCGTGCACTCTCCTGTTGACCCTGCCGCTTGCCGGATACACCTGTCTTTCTCCCTTCGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTGGTATCTCGGTTCGGTGTGGGTCGTTCGCTCAAGCTTAGATGATGCACGAACTACCGTTCGGCCCGACCGCCGCCTTATCGGTAACTATCGTCTTGGGTCCAACCCGGTAAGACACGACAAAGCGCCACAGCGGCAGCCACGGTGGTAAAGTCGATGTGCGAGAGGTTCGAAGAGTACTTAGTGATGGCCTGACTGGCTACACTGAAGAAAGGACAGTTTTAGTGACTCGACCTTCTTTAAGACAGGTTACTGGTTAAGCAGTTCCCCAACTGAAGCAACAGCTGATCGACCCACCTCCCCAGGTGGTTTCGTTTTCAGTTTAGGAGATTACGACTGAACACAATAATCTAGAAGAAACTCCGACAAACTGGTTAAAATCCAATCAAACAGGACTATAAGTAATATTATTTTGATTATACTTGAAAGAAACAGTAGCATAGTGATGCATAAATAAACACATTATTACTATGTAAACAATAAACGAAATGGAAACAAGTTTAAACACATGATAAAAGATATCCACTTAAA 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ACACCAGCGAAGATCCGCGTTTTCATGCCGGTCAGGAGGTGTTACTCACTGGCTGGGGCGTTGGTGAAAACCACTGGGTGGGCTGGCGGAGCAGGCGCGAGTGAAAATGACTGGCTGGTTGCACCATGCCGCAAAGTGGACGTAAAGCAATGATTATCGGTACTGCCGGTTTACCGCCATGCTGTGTGTGATGGCGCTGGAAGATGCCGGTGTTCGCCCGCAGGACAGGAGATTGTCGTGACGGGTGCCAGTGGTGAAAAATTGGCGGTACGCGTGGCGCTGCTGCATAAGTTGGGTTATCAGGTCGTTGCGTTCCGGAAATTCGCATGCCGAATATCTGAAAGTTTAGGTGCCGGTGTCGTCTCCCTCGTGATGGGGTTTGCCGAATCCGTCCTCTGGAGAAAAACAAGTCTGGCTGGGGCAATTGACACTGTTGGCGACAAAGTGCTGGCAAAAGTGCTGGCGCAAATGAATTACGGCGGCTGCGTGGCGGCCTGTGGTCTGGCGGGTGGTTTACTCTGCCAACCACGGTCATGCCATTTATTCTGCGTAATGTCCGTTTGCAAGGGTGGATTCAGTAGCTGACGCCACCAGGGCGCGCGCACAAACCACAGCGGCGGCGATGCCGATTGCCGGAATCATTCCAACACCCGGGCGGCAAAGAAGAATATCTCTGTCAGAGGCACCGAACTTTGCCGAGGCCATCATTAATAACCAGATCCAGGGTCGCACGCTGTTGAAGGTTAACTAACCGTGACCCCAGCAAGGAATAATAGCAAGAGAACTCATTTTGACATCATTATTCAATCGGTTAACGGGAAAAGCGGTTGGCGGGACAACTCGTCGAACACCTTGGTCAGGAAGTTGTACAACATCATCCAAACTGGAAAGTCATGATTTCGACTGACCACAAATTGGTACGCATTGATACTCCTCTAAACAGCCATTATTGATATGCCTCCGTCGCCTGTTAGGTTTATGGTGCTTTGCCTGAGCGACACTACGCCAACCTGTTACTGATTTCTGGTCCATGGGGTGGATAATCTGATTTTATTTGACTACAAATTAACCACTCCGAACTATTTAATGCTGAGAATTGTCAGTGGTTGATTTTGCGTGCTTTAGCATTCACATCTATCAGACGATGCAGTGAAAATTGGGTAATCCCCAGCAACCACGCTGCGTAGCTGTCGTCTATCTTTGTCGCGATCACAAAAACCCTACATTATTTGTGGTCTGTGAAGATTATCACCATTGCAGCCCCTCATCTTCGCAGGGCTGGCTTTCAGCTTTTTCACCTTACGTTATAAAGTTCCGTCGATGATGGCGCTAATTTCGTGGTGTGCAGCTTGTTGCAAAATACACGGTGTTGAAGGTTATTTACGTAGTAGCTGTTGATTATCTTCCCTGATAAGACCAGTATTTAGCTGCCAATTGCTACGAAATCGTTATAATGTGCGACCTCGTCCTCCTGACGCAGTTTTGCGCTGCGGAAAAGGTGACATTGGCGCAACAGAAGGTATATTTGTTTTTTCGGAGGATAGCAGCAGATCGCTGCACAATGTCCATCAAGTCTAACATTGACCTCTGGGGCAAAATAGACCGGCGTCCCGGCCTGCTGGAATTTATAGCCATGCATACAGCTGTCGGGGCATACGCTTTACAGACGGCGGTGAAACGCCTGTCACAATCACACTAAACAAAGAGTACGGAACCCACTCATGGATATTCGTAAGATTAAAAAACTGATCGAGCTGGTTGAGAAGAATCAGGCATCTCGAACTGGAAATCTCCGAAGGCGAAGGTCGAGTACGCATCAGCCGTGCAGCTCCTGCCACAGAGTTTCCTAATGATGCAACAAGCTTACGCTGCACCAATGATTAAAGCAGCCAGCTCAATCTAACGCAGCCGCTCAGCGGCAGCCGTTCCTTCCAGCAGGCTTCCAGCAGCAGCCGGAAATCGATGGTCACATCGTACGCTCCCCGATGGTTGGTACTCTACCACCGCACCCCAAAGCCCGGACTGTACCAAAAGCGTTCATCGAAGTGGGTCAGAAAGAAGTCAACGTGGGCGATACCCTGTGCATCGTTGAAGCCATGAAAATGATGAACCAGATCGAAGCGGACAAAATCCAGGCAGTGAAAGCAATTCTGGTCGAAAGCGGACAACCGGTAAATTTGACGAGCCGCTGGTCGTCATCGAGTAACAGGCGAACATGCTGGATAAAATTGTTATTGCCAACCGCGCTTGAGATTGCATTGCGTATTCTTCGGCCTATCGTAAAGAACTGGGCATCAAGACTGTCGCTGGCTGCACTCCAGCGGATCGCGATCTAAAACACGTATTACTGGCAGATGAAACGGTCTGTATTGGCCCTGCTCCGTCAGTAAAAGTTATCTGAACATCCCGGCAATCATAAGCGCCGCTGAAATCCTCTGCCGGCGCAGTAGCAATCCGCATCCGGGTTACGGCTTCCTCTCCGAGAACGCCAACTTTGCCAGGCAGGTTACAGACGCTCGGCTTTATCTTCATTGGCCCGAAAGCAGACACTATTCGCCTGATGGGTGACAAAGTGATGTCGGCAATCGCGGCGATGAAAAAGCGAACGTTCCTTGCCGTACCAGGTTCTGACGGCCCGCTGGGCGACGATGGATAAAAACCGTTGCCATTGCTAAACGCATAGGTTATCCGGTGATTATCAAAGCCTCCGGCGGCGGCGGCGGTCGTGGTATGCGTGTAGTGCGCGGCGACGCTGAGCAGCGCAATCCATCTCCATGACCCGTGCGGAAGCGAAGGCCGCATTCAGCCAACGATGCCAGTTTACATGGAGAAATGGAAAATCCTCGCCGCATCGAGATTCAGGTACTGGCAAGTCAGGGCAACATCTATCTGGCGGAACGTGACTGCTCTATGCAGCGTCGTCACCAGAAAGTGGTCGAAGAAGCACCAGCACCGGAATTACACCCGGAACTGCGTCTTCATCCGCGGCGAACGTTGTGCTAAAGCGTGTGTTGATGTCAGCTATCGCGGTGCAGGTACTTTCGAGTTTGTTCGAAAACGGCGAGTTCTATTTCATCAGGAAATGAACACCCGTATTCAGGTAGAACACCCGGTTACAGAAATGATCCACCGGCATTGACCTGATCAAAGAACAGCTGCGTATCGCTGCCGGTCAACCGCGTCGATCAAGCCGCAAGAAGAAGTTCACGTTCGCGGCCATGCGGTGGAATGTCGTATCAGCGCCGAAGATCCGAACACCTTCCTGCCAAGCCCGAGCAAAATCACCCGTTTCCACGCACCTGGCGGTTTTGGAGTGCGTTGGGGTCTCATATCTACGCGGAGCTACACCCGTACCGCCGTACTATACAAACTCAATGATCGGTAAGCTGATTTGCTACGGTGAAAACCGTGACGTGGCGAGTGCTCGCATGAAGAATGCGCTGCAGAATGATCATCGACGGTATCAAAACCAACGTTGATCTGCAGATCCGCATCATGAATGACGAAGAACTTCCAGCATGGTGGCACTAACATCCACTATCTGGAGAAAAGAAACTCGGTCTTCAGGAAAATAAGACTACGAAAGCGTCAAAAGGCCGGATTTTCCGGCCTTTATTACAGGGATCTGGCAACCCCCGCAAGGTACAATCCTCTTTTCTTCACCCATCAGGGACAAAAAATGGACACTCGTTTTGTTCAGGCCCATACAAGAAGGCGCGCTGGGCGCTGGGGCTGACCCTTTTTGTGTTGCTTCTTGGTTTTGGTTAGTAGCCGCTTACTTACCTGGCGGTGCCCCCGGTTTTACCGGCTTTCCGCGCTGAGTTTGAGATGGCCCGCCTGCATCCTGACGCCGCTACTGTTTATTGGACTGTGCTGGGCGATGGTGGGAATTTATCTATCGCGATATCCCACTGGAGGATGATGCAGCTTGAAGTAATTCTACCGCAGGTCGCCTATCTGGTGGTGGTGTTCGGTATCTCTGTTTTATGCACGATGCGTAAACGGAGCACCGGCACCGCTGCTTAATAATTATTTCCTCGGCAGCCGCTCTGTGGGCGGTATTGTGCTGGCGATGACGCTCACCGCGACCTATATCAGTGCCAGTTCTGGTTTATCGGCGGGCCGGGAGCTGCTTATAAATACGGCCTGGGCTGGGTATTGCTGGCGATGATTCGGCTTCTGCAGTCTGGCTTTCACTCGGTATTCTCGGCAAAGAAGTTTGCGATTCTTGCGCGCCGCTACAATGCAGTGACATGAACGATATGCTGTTTGCCCGCTACCAGAGTCGTCTTCTGGTGTGGCTGGCGGGATTGAGTTTGCTGGTTGCGTTCGTTTGGTTGCGATGACCGTGCAGTTTATCGGCGGTGCGCGCCTGCTGGAAATCGCGGCGGGTATTCCTTATGAAACCGGGCTGCTGATTTTGGTATCGGCATTGCGTTATATACCGCCTTTGGTGGCTTTTTTCGCGCCAGCGTGCTGAACGACACCATGCAAGGGCTTGTGATGCTGATTGGCACCGTTGTTGCTGCTTATTGGCGTGGTACATGCCGCTGGCGGCTTAAGCAACGCAGTACAGACCTTGCAAACCACCGAATACCACTGCAACTGGTTACGCCACAGGCGCTGAAAGGCGATATTCTGTCGCCTGCCTTTATGACGTGATTCTGGGTACTGGTGTGCTTTGGCGTGATTGGCCTGCCGCATACTGCGGTGCGCTGTATCTCTTATAAAGACAACAAAGCAGTACACCGGGGATATCATCGGTACGATTAGCAGTCATAATCCTGATGTTCGGTATGCACCTGGCCGGAGCGGTGGGTGGTGGTGATCCCCGATCTCACCGTACCGGATCTGGTGATCCCGACGTTTAATGGTAAAAGTGCTGCCACCTTTTGCTGCCGGGATCTTTTTCTGGCTGCACCTATATGGCTGCGATCATGTCGATAATTAACCCCAACTGCTGCAAAGTTCCGCTACGATCATTAAAGATCTCTATCTCGTCCGGATCAAATGCAAAACAGAGACGCGTCTGAAGCGGATGTCGGCGGTAATTACGTTGGTTCTCGGCGCGTTGCTGCTTGCCGCCTGGAAGCCGCCGAAATGATCATCTGGCTGATTGCTAGCCTTCGGTGGGCTGGAAACCGTTTTCCTGGCTGGCCGCTGGTGCTGGGTCTTCCACTGGGAACGCGCAACGCCCAAAGCGCGCTAAGTGCGATGATCCGTTGGCAGCGTGCTGTATGCCGTACTCGCGACGCTGAATATTTCAATTACCTGGGCTTCCACCTATTATTGCCCTCGTTACTACTAAGTTTTCGGCTTTCCTGGTCCACGGAAACCGTTTCGGTACATCCGTCCCGCAAACTACCGTTTTGACTACTGATAAATAAGAAATTTTGCCATTGCCTTGGATCAACTGAAACTGAACACCGGCGCAGACGCGGAAAGTCTTAGCGATGCGCTGGTGGAAGCGGTGCCGTTTCTATCACTTTTTCCGGGATACCCACGATACGCCAGTATTTGGGCCGCTGCCGGGCGAAACGCGCCTGTGGGGCGACACCGATGTGATTGGTCTGTTCGACGCTGGAAACCGATATGAACGACGTGGTGGCGATTCTGGAAAACCATCGCTGCTCGGCGCAGGCTTCGCCTCGAACAACTAGAAGATAAAGACTGGGAAGCGCGAATGGATGGATAATTTCCACCGATGCGCTTTGGTGAACGACTGTGGATCTGCCCTAGCTGGCGTGATGTGCCGGACGAAAACGCCGTCAACGTGATGTTAGATCCAGGGCTGGCGGCGTTTTCAGTACAATTACCCTGATCCAACCACCTCTGTGCCTGCAATGGCTCGACCAGCCTCGATTTAACCGGTAAAACAGTCATCGACTTGGCTGTGGTTCCGGCATTCTGGCGATCGCAGCGCTGAAACTGGGTGCAACAAAAGCCATTGGTATTGATATCGATCACCAGGCGATTCAGGCCAGCCGCGACAGCACCAGACAATGGCGTTTTCTGACCGTCTGGAACTCTACTTACCGAAAGATCAGCCAGAAGAAGTAGCCGACGTGGTGGTCGCTAACATCCTTACAGGCCCATTACGTGAACTGCTTCCTGTCTCTTTTATACACATCTGACGCTGCCGACGAACAC 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-GTTGTACTTCGTTCCGAGTTACGTATTGCTGCGCGCGCACTCTCTGGTCTCGTGGGCTCGGAGATGTATAAGAACCCAGCCCCTGGAACTCCGCTCGTGCGCTCTCTGTTTCCGACCCTGCCGCTTACCGGATGCGCCGTGCGCGCGCACCCTTCGGGAAGCATTGGCGCTTTCTCGCATAGCTCACGCTGTAGGTATCTCGGTTCGGTGTAGGTCGTTCGCTCCAGCTGGGCTGGCGCGAACCCCCGTTCAGCCAAACCGCTTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAGCCCGGTAAGACGACAAGCGCCACTGGCAGCAGCCATTGTAAAAGTCGATGTGCGAGAGGTTCAAGAGAGTACTTGAAGTGATGGCCTGACTTCTGGCTACTGAAGGACAGTTTTGGTGACTCGTCTCGCACAAGACAGTTGCCTGGTTGGCAGTTCCCCAACTGACTTAACCGTGTTGGGTGGTTTGATCGAAGGATCGGATAGTAATGTAACGAGACGAATCACTGTCCTTTCGATGTAAATGTAACAATGAAAGCGATTCTGGCGCCACCGAACCTACAGCTACGCGAAGGAAAAAAGCGATAAGCGCAATCTAAATCAATTAATGTCTTTATAGTCCTGTCGGGTTCGCCACCACTGATTTGAGCATTAATTTTTGTGATGCTCGTCAGAGGAGCGGAGCTGTGGAAAAACGCCCCGCTGGGCGGCCTTATGCTCCTGTCTTTGGTTTGCGCTCCCATGTAAGTTATCTCACTCTCTTACTTGTCACTTAGTCAGCTCCGTCCGCTCGCCGCAGATAAGTGACCGAGCGTAGCAGAGCGAACGATCGAGAAGCGGAAGAGAACCTGATTTCACATGGAGCACTGACGCTGTGATGACGAAACAACAGAAAACTGCGCTTAATATGGCGAACGTTTATCCGAAAGTGCTTTTGTTGGAAAAGCAATGAACTCGATCTGGAAATGTTGAGGCGGATCTTTGC 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-@32c060be-1a2a-4b3d-9f4b-69aba16789f8 -GGTTCAAAGTACTTGAAGTGATGGCCTGACTACAGCTACACTGAGGACAGTTTGGTGACTCGTCTCCGCACAGAAGACGATTTACCTGGTTAAGCAGTTCCC -+ -.>GC;04))*(-0267:=C<<DA><.AH81501//)()688461&<D96;?@<=@?B987B?=?A,@9;4-3'%%&*+'%7;:6>?>34=E>?<97:?;,-- -@49b3c5fc-395b-43bd-92d8-5bc6cdee2622 -GTTGTACTTCGTTCAGTTACGTATTGCTGCGCGCGCTACTCTCTCTAACTCATCGGCAGCGTCAGATGTGTATAAGAGACAGGAATTAATGATGTTTATGTTGAAAAATAAATGGAAAGGCAAAAACGCGGCTCAAACCCTTAGAGCATTTAAAGCATAGAGTCTTTTAATGAAAAAGTATATTAATCATCGGTGCCGACGAATCGTTTTCTGACACGGAAAGATCGATAATTTCAACATTAAATGAGCTTAACATTTCATCACAAACTCGCATAATGGAAATAGCCATTAACGGAAGCACAAAAATATCTTTCTTTGTCGTAGCGGCGGAAGCAAGAATGGCGCAATAGAAGACAATCATTGCTCACGCGTGTAAGGAAAAGAGGTGTTTAGATATATAGACGATCCTATTCAATAAAATAAAAGAAACAAAGAATCTATTATTACATCCTTAGATCCTGATTACATACCCAAATAATGAAAAGAAAGCAAAAGTTCAAGTTCTGTAGTTGTAATAAGAGATGGGGTCCTAGAATAGGCATATCAATGAAGAACAAAACCATTGATACTGACGATGACTTCTTCAGTGAGATAAAGAATTTATAAAAATATGAAACAACTCCACCTACAAAATCATAGCGCAATGACTAAAGACAATTATAAGAAATTTAACATAATGCTGTAATTGTACGCACCGCTGAAACGCGCTGAACGCGATTCTGACGCAGTACCGCAAAGAGATGTTTTACGGGAAAACAGGAAGGATGCGTCAGGATCGTTTTCCAGCTCGCCTGCATATTCACCGTGGCGCGAATGGTGATCGCGGGAGCTTACGTTAATTTCGCACCGTCTGTTTTCGACAGTTTTCTCTCCGGGAAGCTAATCTTGCCATAAGTCTGGATAACAGGGCACGGTGATACCGTAATAGCGATCAACACCTCACCTCCCTGTCCCCGACACGCTTGCCGTCGATAAAGAGTTTTTCTGTAACGCCCCAGTCTCATAACTTCTTTCAGTACTGATCATCAGTCAGTGAGTTAACCTTTCTTACCATGCCGCCGTAAAAACCGGAAACAGTCTTGCCGCATTCAGCAGCCCGCTTTCTGATTTCTGGTCTTCTTCTGCCGTCGACGAACAGAGGCGACTGATAACCCGCCTGCGCCGTATTGCTTCACTTCGTTTTGTCTCAAAAACATGGCTCCGTATCTGACATGGGTGTCAGGAGCCAAAGCCCTGACCAGAACAGTGTAATAGCGTGTATGCGCGGTATAACAATTGCACATCCTGTCCTATCAGCAAGCTCGAATTACCGACAAAGGCACGGCAGTTTTTGGCAGTAACCGGTGTTGTCTGACAAAAATGCAATCAAAAGCCAAGCGGCAAGAATAACGGCATAAAAACAGTCGAAAAGTGGTACGCGATATAATCACACAACGCAGATGACGAACCAGAACGGAGAAAACGAAAAGACGAACAAGCAGCAGCAAGCCGTACTCAACATGGCGGGATTATACAAAAAGTCAGAGCCCTGACGCTGCTCCTTCGAAAAACTGGACGCGCCCGATGCTGACGAACAGGCTGCCATGTTGCGACAAGCTACGAACTCGCGGAAGAACTCAGAACAGCATCCAGACACGCTTTGAAGTAGAAAATAGCACAGAGATAACGCTCAGGACAGGATGCCGAACGGCCTAACGGACGGCAGGAAAATATCCACATAAAGGCGCTCTTCGCTTCCTCGCTCACTGACTCGCTACGCTCGGTCGTTCGACTGCGGCGAGCGGTGTCAGCTCCTCAAAGCGGTAATACGGTTATCCACAGAATCGGGGGATAAAGTCGGAAAGAACATGTGAGCAAAAGCAAAGCACCGGAGGAAAGCCAGCGCCGCGAGCGTTTTTCCATAGGCTCCGCCTGACGAAACATAAAGAATCGACGCTCAAACCAGAGGGGTGGCGAAACCCGACAGGACTATAAAGATACCGGGTGTTTCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTGCCGGATACCTGTCCGCCTTTACTCCCTTCAGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGAATCACCCGCTCAAGCTGGGCTGTGCTGACCCGTTAAACCCGACCGCTGCGCCCATCGAAGGTAACTATCGTCGGAGTCAACCCGGTAAAGGTACGACAAAGCGCCAGCAGCCATTGGTAAAGTCGATGTGCGAGAGGTTCAGAGCGCGAAGTGATGGCCCACATTACAGCTACACTGAAAGGACGGTTTGGTGACTCGTCTCGCACAAGACAGTTACCTGGTTAAGCCACCAATACTCTTATACATCTCCGAGCCCACGAGACCAGAGAGCGCGCGCACCTTGTGCAG 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-GATATACTTCGTTCAAGTTACGTATTGCTGTGCGTCTCGTGGGCTCCGGAGATGTGTGCCGGGAACAGCCGCCGCCCACTCTCTGTCTAACACGCTTGCCCGTCGATAAAGAGTTTTTCTGTAACGCGCCCCCAGCCTCATAACGCTTTCCAGTACCGAATATCAAGTCCAGTGGGATAACTTTCTTACAGGAAGCTGCCGCCGTAAAAACCGGAAACGGTCTTGCCGCATTCAGCAGCCCTTTTTTCTGATTTCCTGGTCTTTGCTTCTGCCCGATGGAACGAACAGGGCGACTGATAGCCCGCCTGCGCGTATTACTTCCACTTACCAGTTTTGTCATAAAACATGGCTCGTATCTGACATGGGTGTCGGGGCAAAGCCCTGATCAGGGTAGTGTAATAGCGTGCATGTATGCGCGGTATAACAATGCACATCCTATTCCTGTCAAGCAGCTCGAATTACCGACAAAAGCACGGCAGTTTTTGGCAGTGACGGTGTTGTCTGACAGAAATGCCCGTCAAAGAGTCAGACAGCAGAATACCCGGCGGTAAAACAGTCGAAAAGTGTACTCGATATAATCACACAACGCAGATGACAGAAAGAACGGAGAAAACAGAAAGATGAACAAGCAGCAGCAAACCGTACTCAACATGGCGGGATTCGCAAAAAGCCAGAGCCTGAGGCTGCTCCGAAAAACTGGACGCACTTGATGCTGACGAACAAGGCCGCCATGTGTGTGGCTGCGAAAACTCATGAAGAACTTCAGAGCAAGCATACAGACACGCTTTGAAGCGGAAAATCGCATGGGATATAACGCACCCCGGACAGGATGCAGAACGTAGCGGAGCGTAAGGAGAAAATGCCACGTCAGACGCTCTTCACTTCCTCGCTCACTGACTCGCGCAGCTCGGTCGTTCGACTGCGGCGAGCGGTGTCCAGCTCACATAGGCGGTAATACGGTTATCCACAGAATCAGGGGATAACGCCGGAAGAACATGTGAGCAAAAGCCATAGAAGCACCGGAACAAACCAGCGCCGTGCCGTTTTCCATAGGCTCCGCCTGACGAGCATCACAAAAATCGACGCTCAAGTCGAGGTGGCGAAACCAAACCGGGACTATAAAGATACCAGGCGTTTCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCCGCCTTTCTCCTTCGGGAAAGCGTGGCGCTTTCATAGCTCACGCTGTTGGTATCCAGTTCGGTGCTTGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCGTTCAGCGCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGAAAGACACGACTTAACGCCACTGGCAGCAGCCATTGGTAACTGATTTAGAGGAGTTGAGGTCTTGAAGTTATGCACCTGATGAAGCTAAACTGAAGAACAAGTTTTGGCGACTGTGCTCCTCAAAGCCAGTTACCTCGGTTTCAGAGCGCCAACTCACCTTCGAAAAACTCCGCCACTCAAGGCGGTTTCATTCAACGTTGATTAATCTCCTTGCTAGCTGCGTCAGCAAAGCCTAACGACTTCAGCCTTCTTTGCCTGGTATTGGCAACAGCTCATGACTGGGAGCCTTCTGGCTACAAGTACTCATCTTTGTGAACTCATCACGCATACAGCAGGCTCTCAAAGCATCATTCTTGATCCTCCATACTTCTCGATGACTAGAGAGCAGAGATCTGTCGCTCACCTGATTCTCCCAGGAGGAGCTACAAGCCAAAGCTCTTTATTAGGGAATCGCTCTCTTACGTATTTAATATAGGGGCATAAGTCAGAATCCGCAGTGATAATAATGGCTATATCATACTCATCATTACACGCACCAGACACTGAACTTATAGCCAAATTAACATCGGACTCTCTTTTTCTTCATGCTTATAAGAAGAAACTCCACCACATCCATTATCAGCTTCGCACGTTACATTCTTTTTTAAAACGTCCACCGATAACATCAACACACCACATTCGGTTAAAGCGTTGGTGTAATTTTGATAATTTTCATTTATGGCTCTTGATAAATGTGATGGCTTAGCGGAAAACCAAAAAACATTATCAATAGATGCACAGGAAGGTATCTCTTGCATAAAGATTTAAGATCAACCCAATGAAGAGCTTTATTACCAGTCTCTTCAATTGCATGATATAAATTATACCTGTCTCTTATACACATCTCCAGGC 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f75b2c81-63ba-46f0-a125-648548ee3f8f -GTTTATACTTCGTTCAATTACGTATTGCTGCCACTTGCTATATACGTGTCTTCGTCAGCAGCGTCAGATGTGTATAAGAGACAGCTCAAAGGCTATTATTAATACGGTTATCCACAGAATCAAGGATAACGCCGGAAAGAACATGTGAGCAAAAGCCAAAGCACCGGAACAAACCAGCGCCGTTGCCGTTTTTTTCCATAGGCTCCGCCCCTGGCGAGCATCACCAAAATCGACGCGCTCAAGTCGGAAATTGGCGAAACCGATAGGACTACTCTAAAGATACAAGCGTTTCCCCTGGAGGCTCCCTCGTGCGCTCTCCTGTTCAAGGCCCTTGCCCAGCACCCCAGATACCGCATCGCCTTTCTCGCTTCCCGGAAGCGTAGCTCTCATAGCTCACGCTGTTGGTATCTCCAGTTCGGTGTGGGTCGTTCGCTCCAAGCTGGGCGGTGTGCACGAACCCCGTTCAGCCCGACCGCTGCGCCTTGTCCGAAGTAACTATCGTCTTGGAGTCAACCCGGAAAGACACGACTTAACGCCACTGGCAGCATGCATTGGTAACTGATTTAGAGGAGTTGAGTCTTGAGTTATGCACCTGATAAGGCTAAACTGAAAGAACAAGTTTTTGGCGACTGTGCTCCTCAAGGCCAGTTACCTCCAGTTCAAAGGCGCCAGCTCTATGGACAGCTGAAGAGCCGCCCGCCAGAGGCGGTTTTCCAGGGTTCATGGGGATGGCGCTCTTTGAACCGGGCTGAAAAGCGCATCGCAAAACTGTTCTTTTCAGTTGCTTATCGGGTGCGCCCCTCGAGACTCAACTTCCTCCCCCAAATCAGTTACCAATGGCTGCTGCCAGTAACAAAATCGTATCTTTCGGTTAGTAGTTACCGGATAAGGCTTACGGCTGTCCTACGCTGGGCTGAAAATTCGTACAGCCAGCGGAGCGAACGACCTACGCCGGAACTGGTATGAGAGCGCCGCGTATTCGAGGAGAAGGCGGACATGAGTATCGATGAAGCCGGGATCAGATGAGAGAGCGCGCGCGAATTTCCAGGAAATTTGT -+ -(%%($%%%%%'6G1;&&&=57;9:780(('$$()/0++,-)(('.*%$$+,40431(,)'1--7;;7@D:.,)'3443,(-/+3??@63/*1%%+'*$&'$$20068?C<))7'4815/&<)*+4FI>>:A;G:<02-.8:>0//3./9@LOC-5&988,/66-BEGGC>8;/2<A<C;7.)#$,34/79<466?9>+-)38=>1;2122&-+,('&-=5+<2(:36-5+8779,.5?AF<=<58(+'*$$)*--*.3/4,%#$&09;68,+5;0AD?***'&#&,68FD==DG>62*,#&5956&-+$%'02470;/591:/)()'(56%%+-+/''$*.-/+.)).*%'1$$)*<%#&56=;3:&'0,%(9-8:9B;;/%%&'1/>.959;7?EC@@DB/19;<?..7$=5@65;05?:3&(.('%(&66:@*;797;:66:--5644-&%--+.?DDD=H3*4'??;?A@A<=B?<?@A@E/&&1(&$&)%%.1.0-(44()/14/&@'(&=;&.$)/778-::8664((0%%(4-?7<4.1.(((868=.5>;;9>@==F48)AG;:=CA97C87'&&&)9-$$%&)42<@A<432%,0139=<A4A67(.:>>28<BA?68854>A:1:AG8?/:-.)0:6.8=1(&-.'/'(543()&&84%%%%%:/5&$&-1/,$*+/024*(+4/()+4442)(*50?098:80%0$'&&.4-//%*-1,7.,&&&(&&(&&&))6'(,*-,*(%%%%#'&%'$+,-(&$4*24-,--0*%)(+$#&*0.7%+0:53%$$$$*)$$21998&''(*+.1+-(&%011,+$2%'%-.()206:<;88282+1'&&.$%'&%%%'%/0..-)$$--$'($&)0,%.&(-+,-'($$$&,'($&%$#%$%%$#$#&%#$%&'+,.*/)-&%#%,/.&,)-')00--96.+%#(:4=8*+*))*%'%$)2&%#)::;0,,'###'%($*'+$&%&+2,5-(&%'%'%&$.*$)$*'$%($'')$%#%$()%&'&%&%)%$$&'$$#%(*/1$%%$$$#&*#$ -@e8221e53-73b5-492a-a94b-1304576f10b7 -GATGTGCTTCGTTCAGTTACGTATTGCGCTAGAGGCTCACTCTCTGTCCTCGTCGGCAGCGTCAGATGTGTAATATAAGAGACAGAAAAATTCTCTTCTTTTCAAGATGCTTTGGTTTGGGCAGAAAGCTAATCCTAGCAAAACGATAATAAGATCTCAGACGGTGTGGGGTTTATTGAAAAATGAAAAGAGTGGATTCACTCAACAAAACAACGATGCATTTTTTGGACAACACCACTGTCTATATACGTACTCATATGTTTCACAGTGTCGTATATTTGAGTCTATGTTACGTACGTTACAGGAGCCTATTTTGACTGGTTACAGGCATTCTTGCAGCAGCTTACAGAAACCCTAGCTGTAATCCAAAGTGACTACCAGGGCTAGACGAACTTTATCCCCCACAAAACCCGCTTTTTAAACGGATCTTCTTGAGATCATTCATGGAGAATCGTAATCTCTTAGCATACAAACGAAAAAAACCGCCCAGCAAGGCAGTTTTTCGAAAGTTCTCCAAAGGCAGCAACTCTTTGAACCAGGGTAACTATTGGAGGAGCACAGTCACCAAAACTTGTCCTTTCAGTTTAGCCTTAACCGGCGCATAGCTTCCAAGACTAACTCCTCTAAATCAGTTACCAGTGGCTGCTGCCAGTGGCGTTTTGTCGTATCTTTGGGGTTGGACTCAAGTCGATAGTTACCAGCGGATAAGACGCAGCGGTCAGACTGAACAGGGGTTCGTGCATACAGTCCGAAAAAGCAGGAGCGAACTGCCTACCGGAACTAGCGAGTGTCAGGCGTGGAGATTAGATAAACGGCCATAACAGCGGAATGACACCGGTAAACCGAAGGCGGGAACAGGAGAGCGCACGAGGGAGCTACCAGGGGAAACGCCTGGGATCTTTATAGTCCTGTCGGGTTTCGCCACCACTGATTAGGCAATCAGATTTCGTGATGCTTGTCAGAGGCAGACCTATGGAAAACGGCAACGCCGCATCCTTTCCTTCCTTTGCAGTTATTCCGCTTAGTCTTTATCCAGCCATTCGTAAGTAGCAACGCCTGCAGTCACGCTTAGGAGCACAGCGACCCGGGTGGGACTGCGGCGAAACACGAAATGGCGCTGGATAAAGAGACAAGCAGAAATCAATCGAAAGAGCAAGGAAAGGATTGCCTTTGACGAAGCATCACGAAATCTCACAGAAGACACGCACATCGTCAGCGGCGTCAGATGTGTATAAGAGACAGAGCTGAACGGAGTGATTTCGCGCAGCAGGATGGAGTTGGTCAGGCGATTGCAGCGAAGACACTTTGAACGCTTCCACGTAGTCAAGCGTTGCCGGATCTTTACCTGATCACGATGTTCTACTCAACCGCCCAGAAAGTTACAAACGCCAGCACTTCCGGTCTGAGCAAAGTTAGACAGCAGTTTCGGTGATGATCAGAGAAGCGGGTTATGGGTGATAGCCGGGGCGATGAAATCCGCACGGTACCATTTGGTTCCTGTGGATCAGCTGGTAGAACGCGTGCTGACCGTTAGTGCCTGGTTCACCCCGGATAATCGGGCCAGTCTAGTAATTCGACGTTACCGTTACAGTCAACGTACTTACCGTTGGACTCCATATTGCCCTGCTAGAGTACGCCGCGAAACGGGCCATATACTGGTCATACGGCGGAATCGCTTCAGTTTCGCGCCAAAGAAATTGTTGTACTGGATGCAATCAGCGCCAGTAAATCACGGGCAGGTTTTTCTCGGCAGGCGTGGTGGAGAAATGCTTGTCCATCGCGTGTGCGCCAGAGAAGCAGTTCAACGAAGTTATCGCAGAAAGCCGATGGAGAGAACAATCCGACAGGCCAATCATGACCATAAAGGTAACGACCACCGACCCAGTCCCCGGAGACTCGGGCATGTTGGCGGTATCAATGCAAACTCGCCAACGGCTTTGGCGTTGGTTAGGAAGCGCGCCGCAAAGTGATGTTTCGCAACGTGTTTTGCATCACCAGCCGCTTTCAGAACCAGTCACGCGCACTATGGGCGTTGGTCATGGTTTCCTGAGTGGTGAAGGTTTTAGATGCTACCAGAGTTGGCAATGGTTTCGGGTTTACTTTTTTCAGCACTTCCGCGATGTGAGTCCATCGACGTTAGAAAGTGCATGTTCAGGTGATTTTTGTACGGACGCAGTGCTTCAGCCAGTCTTTATGCCCATGGAGCCGAGTCAGAACCGCCGATCGATGTTCACTACGTCAGTGATTGCTTTGCCAGTACTTATAACCCTTCCACTCACCGGAAATAATCGCTTGCGAAGGTTTCATCTTCTCCAGCCCGCGTTGACTTCCAGCATAACGTCTTACACCCATCAAGCAGAATCCAGGGTATTGCTACGGACACGCAGCGCTACGTGCAGCACGGCGCAGTTTTCGGTGCAGTTGATCTTCTCACCAGAGAGAACATCGACTTAATCGCGCCCACTGAATCCGCACTCTTTCATAGATCTTATGAGTTCGCCAGCGTCTCTTCAGTGATGCGGTTTGGGTAATCCACCAGCATCTGATCGTCGAAGGTTGCGGAGAACTTAGAAAAACAGTCGCCGTCTTTAGCAAAGATCGGCGATCGTAACGTCTTTCATTTCAACTCAGGAAGTGTTTCTGTAGTACCTGCCAGGCAGCGGTCTGCGTTGGATTGATGTTTTTCATTAGCAATACTCTTCTGATTTTGAAATTGTGACTGGAAGATTAGCGCCAGTCACAGAAAAATGTGATGGTTTAGTACCGTTAGCGTAATGTGGCCGAGTAAACTAACAGCGCAGTGAAGCATTTATTAGCTGAACTACTGACCGCCAAGTGGATGAAAAATCCGCATGACCCCATCGTTGACAACCGCCCCGCTCACCTTTATTTATAAATGTACTACCTGCATGGCGCAGGCCAGAAGAGCGCGTTGCCCAAGTAACGAAGTGTTGGAGGAGCCAGTCCTGTGATAACACCTGAGGGGAGTGCATCGCCGAGGTGATTGAACGGCTGGCCACGGATGGCATCACATCGGCTACAGAGGCTGAATCCCTGATTGTCACCAAGCGTTCGCAGTCAGGCGTTTCGCAAGTGGTAAGACACTTCTGGGTGAAAATAGTAGCGAAGTATCGCTCTGCGCCCACCCGTCTTCCGCTCTTCCCTTGTGCAAGGCTGAAAATGGATCCCTGACACGAGGTAGTTATGTCTGGAAATTGTTGTCTCCAAGTTGGCGGGTACCAGCGTAGCTGATTTGACGCCATGAACCGCAGCGCTGATATTGTGCTTTCTGATTGATGCCAACGTGCGTTTAAGTAGTCGTCCTCTCGGCTTCTGCTGGTATCACTAATCTGCTGGTCGCTTTGGCGGAAGGCTGGAACCTGGCGAGCGATTGAAAAACTCTGACGCTATTCGCAGCATCCGGTTTGCCATTCTGGAACGTCACCGTTACCCGAACGTTATCCGTGAAGAGATTGAACGTCTGCTGAGAACATTACTGTTCTGGCAGAAGCGGCGGCGCTGGCAACGTCTCCGGCGCTGACGGATGAGCTGGTCAGCCACGGCGAGCTGATGATGCTCGACCCTGCTGTTGCTGTCGAAATCCTGCACTGAACGCAGTATTTCAGAGCACAGTGGTTTGATGTACGTAAAGTGATGCGTACCAACGACCGATTTGGTCGTACAGAGCCAGATCTTAGCCGCGCTGGCGAACTGGCCGCGCTGCGGCTATCACGCCTCAATGACGGCGAAGTGATCACCCAGGGATTTATCGGTAGCGAAAATAAAGGTCGTACAACGACCTTGTGGGTGGAGGCAACAGTTATACGGCAGCCTTGCTGGCGGAAGCTTCACCGCATCTCGTGTTGATATCTGGACCGACGTCCCGGGCATCTACACACCACCGATCCACGCGTAGTTTCCGCAGCAAAACGCATTGATAAATCGCGTTTTTACCGAAGCGGCAGAGATGGCAACTTTTAGTGCTGCAAAAGTACTGCATCCGGCAACGTTACGCTACCGCAGTACACGCAGCGATATCCCGGTCTTTGTCGGCTCCGGCAAAGACCGCGCAGGTGGTACGCTGGTGTGCAATAAAACTGAAAATCCGCCGCTGTTCCGCGCTGGCGCTAAATCGCAATCAGACTCTGCTCACTTTGCACAGCCTGAATATACTGCATTCTCGCCTTCCTCGCGGAAGTTTTCGGCATCTCGCGCGGCGTAATATTTCGGTAGACTTAATCACCACGTCAGAAGTAGGCGTGGCATTAACAACCGCCAGTACCACCGGTTCAACCTCCACTGGCGATACGTTGCTGACGCAATCTGCTGATGGAGCTTTCCGCACTGTACCGGGTGGAAGTAGAAGAAGGTCTGGCGCTGGTCGCGTTGAGTTGGCAATGGCTTCTGTCAAAAGCCTGCAGCGTTGGCAAAGAAGGTGTCAGCGTACTGAACCGTTCAACATTCGCATGATTTATTTACGGCGCATCCAGCCATAACCTGTGCTTCCTGGTGCCCGGCGAAGATGCGAGCAGGTGGTGCAAAAACTGCATAGTAATTTGTTGAGTAAATACTGTATGGCCTGGAAGCTATATTTCGGAGCCGTATTGATTTTTGCTTGTCACTATACTCATCAATAAACGAACCTGTACTCTGTTAACCAACATCTTTATCGGAGAATAATTGCCTTTAATTTCTTACATCTCTACGTAAATGCAAATGAAGAGATAATAAGTTAGGCAGGCAAGTGCAGCTCTATAATTGTCTATGAGCAGATTCCCGTACACACTGAACTCTCTGGCTCACTGGGGGCACCAGCGCTCCCCGTATTACCCAAAAGAGATGACTGAACGCGAGCAGCGTGAACTTAAAACACTGCTGGATCGGGCGCGGATTGCGCATGGTCGCTGTACTGACCAACTCCGAAACCAACAGCATTGAAAAAGATACATCGATAAAGTGGTCAGGCGTGAGGCTGAAGCAAAAAAAAAGCCCGCCAGTTAAAGAAAAAGCAGGCTTATAAACCAGCGGATCCACCAGAAGCGTCATTTAGCTGGTCAGCAAATGCGTCGACGCGCGGCAGGCGCAGTTAGCGCCCCTTCTTTTACGCCCGGCGAAGTCAAAAGCCTTACCGTTTGGACGCCGGGCGACCGCCTTTTTCCGCCCGTTTTCCATCATGTGGCACGACTGGACGTTTAATACCTACAGTTTTTCGGTTTGGCCTTCGCTTTAGGTTTTGCCTCGGAAGAGGAATTTTCAATGAGCTTAAAGAGGTCGATTAACTCATCACGTCAGTTAAATCACGCCATTCCCCAGCGGGAATGCCGCTTAAACTAACGTTCATGATGCGCGTACGTTCCAGCTTTTTCACTTCGTAACAAAGTGCTCGCACATGCGACGGATCTGACGGTTCCAGCCCCTGCACCGGGGTAATGCGGAAGACAAACTAACGCTTCTTTTTTGGCTTTACACTTTTTCGTCACCGTCCGAGGATCGCCTCCCGCCCCATACCACGAATGATTCATCGGTAATCAGTTTATCGACCGTCACCAGATACTCTTTCTCATGATCGTTACCGCGGAGGATCTTATTCACCAGATCGCTGTGATTGGTGAGGAAAATCAGCCTAAGTCTTTATCAGGCGGCCAATCAGGAACACGCGTTGCTGTGGTTAACGAAATCGACAATGTTATCGCGCTCGCCATCTTCGGTGGTGCTGACAATACCGACGGAGGCTTGTTCAGGGCGATAAGTACCAAATCTTCGGCTTCAGGCTCAATCCAGCTGACCACGTTTACTTTCCACAACGTCGCCGGAGTTTCACCTGATCGCCAATGGTGGCTCACTCGCCATTAAGGAACACATTGCCTTTACTCGATATAGCGATCCGCTTCGCGGCGTAGAGCAAGATTCCGCTTTCGCTGATACATTTGGCCCAAACGAGGCTGATGAGTCAGGCAGCATAAATTCTCCTGTAAAACGCGGAATATACCGTACCTCTTGGCAGGAAAAACAGGGTTATGCAGCAACGTCAAGAATTAAATGTGATCTGCCACGCCTTTTATCACAAAGTGTCTCCGGAAGTACGATGCAAATTTGCCTGGCAAAATAAGGATGATCAACATATTACGAACCACTGCACACCTTGCTACTGATGGCTACTACTGAAGGCTTCGATGTGCAGAAAGCGCTATTTCTCCCCCCATGCAAAGAGTGAAAAATCGGCACGAAGGCCATCATGATGGGGTTATATCAGATCAAGCCAGGTGAGAAAGCGTGTACACAAATGTACAGGAGAACCAGGAAGGCAGCAATGCAAACAGTGACGATATCCGTTTGGTTGTGAAGATTGCCCAGCTCTATTACGAACAGGATATGACGCGGGTGCCGTCGCGCGAACTGGAGTATTTACCGCACCACCATCAGCCGCTTGCTTAAACGAGGCCATGATCAGGGAATTGTCACCATCACCATCAACTACAACGAAATCTCTCTGACACCGACAGCAACTAAACAAAAAGTTTGGCCTGAAAGACGTTGTGGTGGTGTCAGGAAATGATGAGGATGAAGAGACTCAACTGGCGATGATGGGGTTACACGGCGCGCAACTGCTGGATCGCTTGCTGGAGCCTGGCGATGTCAGTTTTCCTGGGGTCAGCGCGGTGAGCGTGGTTTAAAAAGCTTTGCATTACCTGCCACCAGGCGAAGCAATCGCGGCAGTTAATCTGCGTACCAATTATTGGCGGACCGTCCAGCTGATAAACTCGAAAGCCGCTATCACGTAAACACATTAACCTACAGCGCGGCAGCAAGCCTGCCAAGAAGGGAATCGCATCTCTCGCAGATTTTCCGGCTCTGCTGGATAACCCCTTAATTCGTAATGGGATCATGCAGTCTCAGCGCTTTAAAACCATCTCTGCCTGGGATAATCTGGATGTCGCCCTGGTGAATTGGCTCACACCAGCCATTCGCGACAGCGCTAACGGCATGCGTTTTTATGATGGTGAAGAGAGTGACGACCTGAATGCCCGCCAGGTTGCGCTAACCCGATATTTGCTCGCACTTTTTTGATATTCGGCGCAATGGATTTGAAACGAATATGAGCGAAAAAAACACTCTCTATCGAAATGAATAAATTGAATTAAAGCAGGCACGATATTCCATTGGCATTGCCATGAGTGAAGAAAATACAGCAGGATTGTTGAATTTGCACTGCGTGAAAATATATTAATTGTCTGAGGTAACGAATAGCAGCACAGCTGAACTATTATGAAATAAAAATCTTCCCGATGTTTGTAATAAAAATTACGGCGGGTCCCTATTATCTAAAAACAGGAGTCTATTATGCAAACGTGGTTAAATTTGCAGGATAAATCATTATCGTCACCGGCGGCGCATCAGTATAGGTCTGGCGATTGGCAGAATTAATAGCACAAGGCGCGAATGTACAGATGGTCGATATTCACGGTGGCGATGGACAATATGAAGGTCATAAAGGCTATCAGTTTGGCCGACCGATATTTCCAGCGCGCCAAAGAGGTAAATCATACGGGACGAAGCGCGAGAAATATCTTCAAGCGTGCAGCCGTGAGCGATTATATACGATTGTTTTCCGAGGTCATTTACGCGTCATACTAAATAAATACAAGTAAGTGCGGAAGCGTATAAGAAAAAAGCATTACATTAGAAAAGTATGCGTGAATATAAAAGCCAGAAGCGTTATTACAGCATTTGCTTTTATGATGATGATAAATCTTTGCGACGGCGCGATGCGATCACGGCGCTACATGGAAATGTTTGGGAATGGAACTGGGCTCAGAAGCAATATGATGTGGAGCGGGTGTTTTTGATCTAATATGGTGATAACCTTTCTTTTTAAAAGATGGAAAAAACAGACATACCTTTTTCGCAGAATATATGAAAAGCTTTAATGACGTGCATGACCTACCATCAGAAGTGATGAAACAAATGGTGCAGGAGTGCAGATATGACGCGGAAACGACGAGAATAAATATTATTTGCGTGATACCTTTTTGCCATGCACTTTGGATGGATATGGAATATCGGTGTTTAGTAACATAAGTAGCAGGAAGTGAATGGGTGC 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-CGCATCGGTGTTTGTACTTCGTTCAGTTTTCGCCTTTGCTGCGCGCGCACTACTCTCTGGTCTCGTGGGCTCAGGATGTAGCTATAGAGACAGATCCCCGACACACTTGCAAATCGGTGAGTTTTCTGCGCCCAGTCCTCAACTTCTTTTTCAGTACCAGTCAATGATCAATTAGGTTAACTTTCTCTTACCGAGGCTGCGCGTAAAAACCAGAGCAGATCTCTTGCCGCGTTCAATGACCCTTTTCAGTTCCTATGGTCTTCATGCAAATCGGACGAACAGGGCGACTGATAGCCCGCCACGCGCGTATTACTTCACTTCATTTTGTCATAAAACGCGGCTCCGTATCTGACATGGGTGTCAGACGAAATACAATAGAACAGTGTAATAGCGTGTGCTGCCAGAGTATAACAATTTGCACATCCATAATCATGTCAGCAGGCTCAGATTATGACAAAGGCGGCGGTTTTTGGCGGTAACCGGTGTTTATCTGACAGAAATGCCCGTCAAAGCAAACCTGGCAGAATAGCAACAGCAAAACAGTCAAAAGTGGTACGCGATATAATCCCTGGCACCGGATGACAGACAGAACGGAAAACGAAAGAGATGAACAACGACAGCAAAGCCCGTACTCAACATGGCGGGATTGCAAAAGTCAGGCCTGACGCTGCTCGAAAAACTGGATACCGATGCTGACGAACGGGCTGCCATGTGTGAGGAAGCTGCACGACTCGCAGAAGAACTCAGAACAGCATCAGACCGCTTTGAAGTGAAAATGGCACGGAGATAGCATCAGGACAGGGATGCCGAACGGCTACAACAGAACATGGAGGAAAATATCACATAAGGCGCTCTTCGCCTCGCTCTTGCCAGCTGCTTTACGCTCGGTCGTTCGACTGCGGCAGGCGGTGTCAGCTCACTCAAAAGCGGTAATACGGTTATCCCACAGAATCGGGGATAAAGTCGGAAAGGGCATGAGCAAAGAAATAGCAAAAGCCACCGGAAATGACGCCGCAGACGTTTTATAGGCTCCGCCCCCTGATAGGCATCCCACAAAAATCGACGCACTCAAGCCAGGGTGGCGAAACCCGACAGGACTATAAGATGGTGTTTCCCCTGGAGCTCCTCATGCGCTCTCCTGTTCCGACCCTGCCGCTTTGGATACCTGTCCGCCTTTCTCCCTTCCGGAAGCATGGCGCTTTCTCATAGCTCACGCCGTAGGTATCTCAGTTCGGTGTAAGGTCCTGTCTCTTATACATCTGACGCTGCCGACGACAGAGTGCGCGCGCATGTGCATATGTGCT 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-CCTACAGCGTGAGCTATGAGAAAGCGCCACGCTTCCCGAAGGGAGAGAAAGGCGGACAGGTATCCGGTAAAGCAGGGTCGGAACAGGAGAGCGCACGGAGGAGCTTCGGGAAACACCTGGTATCTTTATAGTCCTGTCGGGTTTCGCCACCTCTGGCTTGAGCGTCGATTTTGTGATGCTCGTCAGGAGACTGAGCCTATGGAAAAACGCCTGCGGCGCTGGCTTCCTCCGGTGCTGCTTTTTGCTCACATGTTCTTTCCGACTTTATCCCCGATTCTGGGGATAACCGTATTACGCTTTGGGTGAGGCTGACACCGCTCGCCGCAGTCGAACGACCGAGCGTAGCGAATCAGTGAGCGAGGAAGCGGAAGAGCGCCTTATGTGACATTTTCTCCTTACGCTCTGTTGTGCCGTTCGGCATCCTGTCCTGAGCGTTATCTCTCTGTGCTATTTTCTACTTCAAAGCGTGTCTGGATGCTGTTCTGGAGTTCTTCTGCGGGTTCGTGCAGCTTCTCACACATGGCAGCCTGTTCGTCAGCATCAGATTGCGTCCAGTTTTTCGAGCAGCGTCAGTCTGGCTTTTTATGAATCCGCCATGTTGAGTACGGCTTGCTGCTGCTTGTTCATCTTTCGTTTTCTCCGTTCTGTGTCATCTGCGTTGTGTGATTATATCGCGTACCACTTTTCGACTGTTTTGCTGCCGTTATTCTGCCGCTTATGGCTTTGACGAGCATTTCTGTCAGACAACGCCGCCATCACTGCCAAAAAAACTGCCATTTTTGTTTGTCGGTAATTCGACTTGCTGACAGGACCAGGATGTGCAATTGTTATACCGCGCATACATACGCTATTACAATTGCCCTGGTCAGGGCTTTTGCCCCGACTACCCATGTCAGATACAGACGCGTTTTGCCGACAAAGCAGGTGATATCTGCGCAGGCGATATCAGTCGCCCTGTTCGTCTGACGGCAGAAGAAGACCAGGAAATCCAGAAAAGGGCTGCTGGTGCGACAAATTGTTTCCGGTTTTTTACGGGCAGCAGCTCTCGGTAAGAAAGTTAACTCACTGACTGATGATGGGTACTGAAAAGTTATGAGACTGGGGGCGTTACAGAAAAAACTCTTTATCGACGGCAAGCGTGTCGGGGACAGGAATTATGCGGAGGTGCTGATCCTTTATTACGGAGTATCACCGTGCCCTGTTATCAGACTTATGGCAGATTAGCTTCCCGGAGAGAAAACTGTCGAAAACAGACGGTATGAACACCGTAAGCTCCCAAAGTGATCACCATTCGCTTTCATGCATAGCTATGCAGCGAGCTGAAAACGATCCTGACGCATCCTTCCTGTTTTCCCGGGGTAAAACATCTCTTT 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-GTTGTACTTCGTTCAGGTTACGTGTGCTACGCACTCTCTGTCGTCGGCAGCGTCAGATATTATAAAGACAGCAGACGAACAGGGCGACTGATAGCCCATATGCATACTTCCGCTTTGTTTGTCACAAAACATGGCTCCATCTATCTGACATGGGTGTCAGGGCGAAGCACGATGGAACCAGTTGTAATAGCGTGCATGCCATGCGCGGTATAGCAATTGCACATCCTGTCCTGTCAACGGCTCGAGATTACCGACAAAGGCACGGCGGTTTTTGGCAGTGACGGTGTTGTCTGACTAAAAATGCCCGTCAAAAGCCAAGCGGCAGAATAACGGCAACAAAACAGTCGAAAAATTAGTACGCGATATAATCACACAACGCAGACAGCCAGACAGAACTGGAGAAAACGAAAGATGAACAAGCAACGGCAAGCCGTACTCCAACATGGCGGGATTCATAAAGAGGGTCAGAGCCTGACGCTGCTCGAAAAACTGGACACTCGCGATGCTGACGAACAGGCTGCCATGTGTGAGAAGCTGCACGAACTCGCAGAAGAACTCCAGAACAGCATCCAGACACGCTTTGAGTAGAAAATGGCACAGAGAGATAACGCTCGGAACAGGATGCCGAACGGCTAGCAGGCAATAAGGAGAAAAATGTCTACATAAGGCGCTCTTCCCTTTACTCGCTCACCTGACTCGCTACGCTCGGTCGTTTCGACTGCGGCGAGCGGTGTCAACTCACTCAAAAGCGCGGTAACTCACGGTTATCCACCAGAATCGGGGACAAGTCCGGAAAGAACATGTGAAACAAAAGCAAAGCGCCGGAGAAAGCCAGCGCCGTTTTCCATAGGCTCCGCCCCTGACGAAGCATCACAAAATCGACGCTCAAGCCAGAGGTGGCGAAACCCGACAGGACTATAAAGATACTGGTGTTCCTGGAAGCTCCTCGTGCGCTCTCCTGTTCCGACCCTGCCCGCTTCGGATACCTGTCCGCCTTTCTCCAGCTTCAGGAAGCGTGGCGCTTTCCGCAGCTCACGCTGTATGATTGCTGTCTCTTATACATCTCGAGCCATGAGACAGAGTGCGCGCGCAGCAATGCGTAGC 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-TTAAAAAAAAAAAAAACAATCGTGTGCGCTAGTTCGGTTGGCATTGCTGCGCGCGCACTCTCTGGTCTCGTGGAGAAATCCAGGATGTGTATAAAGAGACATCATTTAAATGAGCTTAACATTTCATCTATAAGCATACTTGCCAATGAAATAGCCATTAACGGAAGCACAAAAATATCTTTCTTTATCATACCGGGAAAAAACAAAGATAGCGCAATGAGGAATCTAATCATTGCTCACGCGTGTAAGAAGAGGTGTTTAGATATGTAAGACGATCATTAATGTAAAATAAAGAACAAAATCTACTATTACATCCTTAGATCTGATTACGCTTACCCAAATAATGAAAAGAAAGCAAAGTTCAAGTTTACCTTAGTTGTAATAAGGAATCAGATTCTAGAATAGGCATATCAATGAAGAACAAAACCATTGATACTGACGATGACTGCTTCAGTGAGATAAAAGAATTTATATCAAAAATATGAAAACAACTCTCTACCTACAAAATCATAGCGCAATGACTAAGTGATTATAAAATTTAACATAATGCTGTAATTACCGCACCGCTGAAAGCGCGCTGAACGCGATTCTGACGCAGACACCGCAAAAGATGTTTTACCCAGAAACCGGAAGATCGTCAGGATGCATTTTCAGCTCGCTGCATAGCTATGCATAAAGCGAATGGTGATCACTTGGGGCGCACGGTGTTCATACCGTCTGTTTCGAAGCTCAGTTTCTATCTCCATGAAGCTAATCTGCCATAAGTCTGTGGATAACAGGGCCTGAAGTGATACTCCGTAATAGCGATCAGCACCTCCGTACTCCCTGTCCCCGACGCAACTTTACCAAATCGTCAAAGTTTTCTGTAACGCCCCCGGTCATAACTTCTTTCAGTACCCGATCATCAGTCAGTGGAGTTAACTCTACACACCGAGAGCTGCCGCCCGTAAAACCGGAAACGGTCTTGCCGCATTCAGCAGCCCTTTTTCTGATTTCCTGGTCTTCTTCTGCCATCAGACGAACAGGGCGACTGATAACCCGCCTGCTTGCCCAGTATTACTTCCACTTCGTTTTGTCATAAAACACATCCATATCGGCGTAGATTGTCGGGGCAAAGCTGATATCGGGCAATAGTAATAGCGTGCATGTATGCGCGGTATAACAATTACCACAATCTGATCTGTCAGCAAGCTCGAATTACCGACGAGGCACGGCAGTTTTTGGCAGTGGCAGCAGTGTTGTCTGGCTTAAATACCCGTCAAAAAGCCAAAGCGGCAGAATAACAGCAACAAAACAGTCGAAAAGTGGTACGCGATATAATCTACACACAACGCAGATGACAGACAGAACGGAAAACGAAAAGATGAGCTTAAACAGCAACAAACTATTCACTCCAACATGGCGGGATTCATAAAAGTCAACAAGCCTGACGCTGCTCAAACTGGACCTACACCGATCTCTTATTGAACGGGCTGCCATGTGTGAGAAGCTGCGAACTCATGAAGAACTCAGGAACCACCATCTCTTATACATCTCGAATACCCACGGGAATGGAGGTGCGCGCGTGATACGTGGCAGCAACGTAAC 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-@ece40f73-48e4-4d5e-931b-efee0e570ddd -GATGTACTTCGTTCAGTTACGTATTGCTGCGCGCACTCTCTGTCGTCAGCGTCAGATGTGTATAAGAACGGTTGTTCTGGGACCGTGCAGCTTCTCACATGGCAGCCTGTTCGTCAGCATCCGGGTGCGATCCAGTTTTTCGAGCAGCGTCAGGCTCTGACTTTTTATGAATCCCGCCATGTTGAGTACGGCTTGCATAACAGCGTTTCATCTTTTTCGTTTTCTCCGTTCTGTCTGTATCTGCGTTTATTGTGATTATATCGCGTACCACTTTTCGACTGTTTTGCTGCCGTTATTCTGCCGCTTGGCTTTTTTGACAGGCATTTCTGTCAGACAACACTGTCACTGCCAAAAAACTGCCGTGCCTTTGCATCGGTAATTCGAGCTTGCTGACGGGACAGGATGTGCGATTGTTATACCGCGCATACGCATGCACGCTGTACAATTC -+ -'$($,/12-)-C83.<?@=@<FAAD<5@<4/%***'-1?BB>;7/1,$*//**)/,*%%%&;>45+),-&70,#$'##$%,#%+03+)%,*27:@D->;98<;75A@:?B<;8A:1>B:&&?3.55/1%%&&8.<68?7.4,(+52:8266,5GH3C/JC77)%%%*+%%&%%67288900@02'5+';:<676*$$$++-,;>@FC;D<?CHFNJC?@LDYB>@)?=F652+06)&$048()<9==,$%&&553A:+&%14:>?@??A)9:=>>>787:AAAMKBCJ?=?;KI?B><62.83$$)6>33?C:8690*&+4??BDCC@0(9''@=?63=;<2<AACB?;>FED?FAAED?/(<,+,-/'"&*6A16=>D>@>;93@AC?B7G@D).D>6/==82,2+&%#$&-(**)-?@@?GE?<<=$$((($%1--7'3/78:46( -@5bb760a4-3566-402d-a25b-b0674ea4c1c4 -GTTGTACTTCGTTCAGTTACGTATTGCTGCACGCGCACTCTCTGTCGTCGGCGGCGTCAGATGTGTATAAGAGACAGGTCTGGATAACAGGGCACGGTGATACTCCGTAATAGCGATCAGCACCCTCCGCATACTCCTGTCCCCGACACGCTTGCCGTCGATAAAGAGTTTTTTCTGTAACACCCCCAGTCCTCATAACTTCTTTCAGTACCCGATCATCCAGTCGGTGAGTTAACTTTCCACCGAGAGCTGCCGCCCGTAAAACCGGAAACGGTCTTGCGCATTCAACCCAGCCCTTTTCTGTTCCTGGTCCTCTTCTGCCGTCAGACAGGCAGGGCGACGATAGCCCGCCTGCGCGTATTACTTCCACTTCGTTTTGTCGCAAAACATGGCTCCGTATCTGACGTGGGTGTCGAAGCCAAAGCCCTGATAAGACAGTAGCTAAGCGTGCATGTAGCTGCGCCCGGTATAACAATTGCACATCTATCCTATCAGCAAGCTCGAATTACCGACAGAGCCACGGCAGTTTTTAGCAGTGACAATTGTCTGACAGAAATGCCCGTCAAAAAGCCAAGCGGCAGAATAACGGCAGCAAAACAGTCGAAAAGTGGTACGCGATATAATCACACAACGCAGATGACAGACAGAACGGAAGAAAACGAAAGATGAACAAGCGGCAGCAAGCCGTACTCAACATGGCAGGATTCATAAAAGTCAGAGCCTGACGCTGCTCGAAAAAACTGGACTACACCCGATGCTACGGCGAACAGGCTGCCATGTGGCGAGAAGCTGCTGCTTGTTCATCTTTTCGTTTCTCCGTTCTATCATCATCTACGTTAATGTGATTACTGTCTCTTATACATCTCCAGGCCCACGAGACCGGAGTGCGCAGCGGTACGTAACT -+ -((*)+)666<;G(/',<?:BCDAB:3161&&)/')&&&18@7>7<A<;9(03%.:?<11-0*%)$56<33(+8.1+5;2>58;EG;:-)@+A?9733FFFA?:=<DIIAB>@CDC-)B>;:><:6<:A8B:896856--:>IKC;>9'),0669:<:;?;=@=>7&%&(1.08986**))92@AF;664''6-=+***(.5--/&414>92C8>?;ED$$C>?9A$*)%)857-0/79=27>;-200,/999<>566C<<BC@?4?13+4;A&2<=?=)32F?C@@&&&4*'3=:019B65+'&/%';9;118<D?>8?<CDA>EAAG0#%%+$694-1*&#(%%&146466>>B5-''('++-..%*$%(()*04B<<9?$$9<<7=,:7?DF26?C62E5B86.B.0.F=40&$%-&4,-,%%%$%%'$#$%&&%$'%''$&&0:7B7=42*.'/0:782(//$*351,,=&'&(;90=-$;(%((++$$9207&'0575,,88?6:40141--,+506,54-:1596-%.+(.4-)(')')&56131,1+33=67KOG??9=?H=677<12::<=9<5CFC@?;45.5%<ABA::124@;>@557I@DFAB??BFFGG>75>1/1@DC@'546B<A54$%+()'*-,$($((/,1-0*,5.)EE89AIFH<:$.7A1>24%'(&.8&0B89B4A:;,$<=6CEA9:EKI==:2;,3?CC@A:3.:D:.2::@AAFCD=8'(0#$%&''''=A>8/,%%%%055862>D?D;9=.50-+&$*&8$:6:;3237344*389<:::632%).042<4;'6;61+3*5:A:7@/+/8<>-.8821+)-&$+%((=><=72.E?:=9&4&&3ABA4520><74$('4<)AH?9<7$,,..$$/1,( -@3d165071-e1ad-4397-bcc5-e460e130f807 -GTTGTACTTCGTTCAGTTACATGTGCTGCGCGCGCACTCTCTCTGGTCTCGTGGGCTCGGAATGTGTATAAGAGACAGATTGTAATAGCGTGCATGTATGCAGTATAGCAATTGCACATCCTGTCCTGTCAGCAAGCTCGAATTACCGACAAAGCACGGCAGTTTTGGCAGTGACGGTGTTGTCTGACAGAAATGCCCGTCAAAAGCCAAGCGGCGAGAATAACGGCAACAAAACAGTCAAAGAAGTGGTACTTGATATAATCACACAACACCAGATGACAGACAGAACGGAAAAAACGAAAAGATGAACAAGCAGCAGCAAGCCGTACTCAAGCAGGATTCATAAAAGTCAAGAGCCTGACGCTGCTCGAAAAACTGGACGCACCCGATGCTGACGAACAGGCTGCCATGTGTAGAAGCCTGTCTCTTATACCCCCACATCTGACGCTGCCGACGACAGA -+ -&(**-.453;>I+2+3=>;:&&%*$496,0*-&16356+/-+0/./,,(<7G7>G=3<.4%.),:=<<9+,*&,'++*')3,(59=9B@@DD?<;6,+)'(%%('.9$=6659;D=AF00>C?66<50-@A9>23=@955./=A9E@=BBDF/+9%%031.<9=OF/34',>=8<(280/2+0>7H@,-*0?I;>B:229=FFA;7==775:,1,$%(2<A?@?>A?<;??AIA0,/(;*,)&''8?/1;+&&&:9CGH;:78/:44<<9$$6/A?@@6A9:G8>6A<:/3.04(@CC?EI@/9FG@>CEFG:51>7>5?>?76*'$%$*8.%$$((9/BC>10?@B06>A%&180CCBC<96:@@H@69>B@C@=>9?D;124666>BM?9@E@6++23<>JCHFBD1//573400/2756'56?>770-*02123(<;8,/44<215%%'$3<?9),%' -@782a0d64-0ef9-4f73-b2d4-c0683389dedd -CATCAGGGTGCGTCCAGTTTTCGAGCAGCGTCAGGCTCTGACTTTTATGAATCCCGCCATGTTGAGTACGGCTTGCTGCTAGCGTTTCATCTTTTCGTTTTCTCCGTTCTGTCTGTCATCTGCGTTATTATTTGATTATATGCATGCACTTTTCGGCCTGTTTTGCTGCCGTTATTCTGCCGCTTGGCTTTTTGACAGGCACTTCTGTCGGAACAACACTGTCACTGCAAAAAACTGCCATTTTATTTTGTCCGGTGATTCTTCGAGCTTGCTGACAAGGACAGATATTCTGGTGTTATACCGCGCATACATACCACTTCTTCAATCACCTGGTCAGGGCTTTGCCCGATACCCATAAGATACGGAGCCATGTTTATGACAAAACGAAGTGGAAGTAATACGCGCAGGCGAGCTCACATCATGATCGCCCTGTTCGTCTGACGGCAGAAAGACCAGGAAATCAGAAAAGGGCTGCTGAATGCACGGCAAGACCGTTTCCGGTTTTACGGGCGGCAGCTCTCGGTAAAGAAAGTTAACTCACCTGACTGGTGATCGGGTGCTGAAAGAAGTTATGAGACTGGGGCGTTACAGAAAAACTCTTTATCGACGGCAAGCGTGTCGGGGGACTGGGGAGTATGCGGGAGGTGCTGATCGCTGTACGGAGGTATCACCGTGCCCTGTTATCAGACTTATAGCTGATTAGCTACCCCGGAGAAAACTGTGAAAACAGACGGTATGAACACGTAAGCTCCAAAGTGATCACCATTCGCTTTCATGCATAGCTATGCAGCGGGCTGAAAACATTTGAGCGCACATCCTTCCTGTTTTCCCAGGGTAAAAACATCTCTTT -+ -$-1+%',&6.0.%%846;<J95,&*1+6C=81%+'$$*%++01142+,*)*33=;246776/2**-3,129>BB'&3)%%%'(,8=.+++2/@E:<<>;@>?@<@<C?>@;9;<;=@515%#$&'*&%&#')122DC>950&#%'$&)+,2::5$%+&1038F>;=C;-44@E?ABBBB@@2/27/.:;:77,7$/,.6><@HG@;2-1&*(8267=??A.*8($&%,27;12*572)),)+1258:>?<&&@*0(%'..'%'%$$*22367@H87(),61'((-)&3-&&%&=:2.'&&%/$$"'*+8;40)$0##$($&&$$$$#&65@=703.4?0':;6&'(')%%+463$%'*9C<992544==>@:>>1>B@BHFFC8;<<<?F:>=+34000-2-./.*45,)&'*(&$%'(*#%&';@AB<)256:=2+=.A;G-46847:'(@9;;>4*/?3D44<2?3%/C@FEB>@6C:9$$2013,.*45>7?;E29:?ACGC??5847*+$%*(+)%?+12$%$-2,14=@9920&$*$4:844%'34-(5$&$<'*(((393;:>=?E@:8:<5<(/:BBCLF=<,,:8@AI@A=BCGF><>?C$-:HD4.*?<;@&',')-(-),84359352314/'153,))*#$4'46)+&.%($%(01.?9A@<F4GGGE?FD+'1&-2266%,%&#$%%%.-582-&@A@4555-58742,'&35;23/2&127:@=7770)/%'#$(79*1465-9;4.?889=BAB<<KLKE;=AJ;:2FB>@</4(<<==?=:6333*/$$$$&&'4//-099;AA@<?>A=>U658'%0014021*)3:?A:7;7; -@f14ca0e8-faaf-4e9f-b5ce-5d4874aa0bc1 -AGTACAGCTTGCTGCTGCTTGTTTTCATCTTTTCGTTTTCTCCGTTCTGTCTGTATCTGCGTTGTGTGATTACTATCGTACCACTTTTCGACTGTTTTGCTGCCGTTATTCTGTAACCTTGGCTTTTTTGACGGGCATTTCTGTCAGGCGCTTACTGTCACTGCCAAAAAACTGCAATACCTTTGTCAGTAATTCGGGTGCTGACAGGACAGGATGTACAATTGTTATACCGCGCGCCACATGCGCTTCAATACAATTGCCCTGAGGTCGGGGGCTTTGCCCCGAACACCCATGTCAGATGCAGACCATGTTTTGCCAAACCAGCAAAGTGAGTAATACGCGCGCAGGCGGGCTATCAGTCGCCCTGTTCGTCTGACGGCAGAAGACCAGGGAAATCAGAAGGGCTGCTGAATGCGGCAGCAAGACCGTTTCCGGTTTTTACGGGCGGCAGCTCTCGGTAAGAAAGTTAACTCACTGACTGATGATCGGGTACTGAATAAAGTTATGAGACTGAGGCGTTACAGAAAAAACTCTTTATCGACGGCAAGCGTGTCGGAGGACAGGGAGCTATGCGGAGGTGCTGATCCTCATGCGGAGTATCACCGTGCCTATCCAGACTTATGGCAGATTAAGCTTCCCGGAGAAAACTGTCAATAGTGGTATGAACACCGTAAGCTCCCAAGTGATCACCATTCGCTTTCGGCCCGCATAGCTATGCAGCGGGCTGAAAACGATCCTGACGCATCCTTCCTGTTTTCCAGGGTAAAACATCTCTTT -+ -,.;6/-88899=@>9;95888658;=??@>;>9*116I;7<7@=DAD>999/($&-/))(%%%(($$%$3-%%*))*(.05628???<5208;:@>B7(%.9==7BECAA;,,(''&*&'%*+9:===;:7/$&5>8>CC82,&0$%*/-///@??62.&(,***430010,.**%%((/2/<D;80&.@@B@59$'&&(,-?:+',),.&748:,('+++*,;9<-''>?5-+&&&&+)%&&0)1437/,%&<45397>>:07'(./1$',,%&&&'((%$$&'')0676-33.0%'4=5)2)7A@3?ABF?:0).(,''%%&7.0,)18+(;40*337$><85034D)*<:9+&2*+(93@?A8BADC2,?1@,,*.3((1+;;685<87%+<:<<69:%4=@DB:884;8:=49,-)4'((6;>;A;;'<&*).7872>7<A=*2.+,.*5*,()-&(/3+9C@CEEAC@A>AKHA8D@BC5+-,)8??=CJDC<2534@D@=>>EB,*3)-??>@A/.3/88DBDA<83214;9:81(.2314%02<43<)/;D:=1()%%'$$+2108-/%%'@315;4%%,$&$%'4%($$(0/:44415+0-%6//B66CBGEBB00(1'+*/$&56675>=+,-&2*-(%$$%)$%$%',$&))6763-25857..5BB?BD67/54.+:,01<><:%$=@51%%%%%$&&&'-1+6/..*;:%'10225EB>?<=--2266@339:;@EB>?B?>>??-1%0-6/+-1?A?<?81546 -@bb40d038-68bf-4de8-842a-35072f4afd60 -GACATACTTCGTTCCGGTTACGTATTGCTGCGCGCCACTCTCTGGTCTCGTGGGCTCGGAGATGTGTATAAGAGACAGAAGTTTACCTTAGTTGTAATAAGGAATCAGATTCTAGAATAGGCATATCAATGAAGAACAAAACCATTGATACTGACGATGACTGCTTCCAGTGAGATAAAGAAATTTATATCAAAATATGAAACAACTCCACCTACAAAATCATAGCGCAATGACTAAAGACAATTATAAAATTTAACATAATGCTGTAATTGTACGCACCTTTGAAACGCGCTGAACGCGATTCTGACGCAGGCCCACCGCAAAGAGATGTTTACCCCGGGGAAAACGGGAAGGATGCGTCAGGATCGTTTTCAGCTCGCTGCATAGCTATGCATGAAAGCGAATGGTGATCACTCTGGGAGCTTACGATTGTTCATACCGTCTGTTTTCGACAGTTTTCTCTCCGGGAAGCTAATCTGCCATAAGTCTGGATAACAGGGCACGGTGATACTCCGTAATAGCGATCAGCACCTCCACATACTCCCTGTCCCCGACACGCTTGCCGTCGATAAAGTTTTCTGTAACGCCCCAGTCTCACTTAACTTCTTTCAGTACCCGATCATCAAGTCAGTGAGTTAACTTTCTTACCGAGCTGCCGCCGTAAAAAACCGGAAACGGTCTTGCCGCATTCAGCAGCCCTTTTTCACCTGATTTCCTGGTCTTCTTCTGCCGTCAGACGAACAGGACGACTGATAACCCGCCTGCGCGTATTACTTCCACTTCGTTTGTCATAAAACATGGCTCCGTATCTGACATGAGTGTCGGGGCAAAGCCCACGATGGAACAGTGCAATAGCGTGCATGTATGCGCGGTATAACGATTGCACATCCTGTCCTGTCAGCAAGCTCGAATTACAAACAAAGGCACGGCAGTTTTGGCAGTGACAGTGTTGTCTGACGACAGAAATGCCCGTCAAAAAGCCAAGCGGCAGAATAACGGCAGCAAAACAGTCGAAAAGTGGTACGCGATATAATCACAACACCAGATGACAGACAGAACGAGACTATCTCTTATACACATCTGACGCTGCCGACGACAGAGAGTGCGCGCAACAATACGTAACT 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d070ef6f-29a5-43f1-937a-75bc0417dd59 -GTTCTGTCTGTCATCTGCGTTGTGTGATTATATCGCGTACCACTTTTTCGACTGTTTGCTGCCGTTATTCTGCCGCTTGGCTTTTTGACTGAGCATTTCTGTCAGACAACACTGTCACTGCCAAAAAACGCCGTGCCTTTGTCGGTAATTCAGTGAGCTTGCTGACAGGACAGGATGCAATTGTTATACCGCGTATACACGCTATTACACAATTGCCCCTGGTCAGGGCTTTGCCCCGACACCATGTCAGATACGGAGCATGTTTTTATAATAAAACGAAGAGGTGGAAGTAATACGCTGAGCGGGCTATCGGTCGCCCTGTTCGTCTGACAGCAGAAAGAAGACCGGGAAATCAGAAAAGGGCTGCTGAATGCGGCAAGACCGTTTCCGGTTTTACCAGGCGGCAGCTCTCGGTAAGAAAGTTAACTCGCGACTGATGATCCGGGTACTGAAAAGTTATGAGACTGGGGGCGTTGAAAAAACTCTTTATCGACGGCAAACGTGTCAGGGGACAGGAGTATTGTCTGGAGGTGCTGATCCTTACGGGTATCACCGTGCCCTGTTATCAGACTTATGGCAGATTAGCTTCGGAGAGAAAAAACTGTCCGAAAACAGACAAATATGAACGTAAGCTCCCAAAGTGATCACCATTCGCTTTCATGCCAGCTATGCGGCAGAGCTGAAAACGATCCTGACGCATCCTTCCTGTTTTTCCCCGGGGTAAAACATCTCTTT -+ -;?==:;<??523,<<86A;>?.;0;<=>12;<8A9/20==<?<AFFCBBC@@@DCDA88BB@B;HC@@A<((;=:=AB<E@AAA=66/'&-'?B>?A?=5016%%5388=8?A50.()<<BBIF98:+&&&(.A0(+(-?+$@)-?>AA95$(('&-28;9:?B<,/);-*)213''.6:5>9A@:55980/&&(++(6<=<5--/(%)4&(&,)99<32113.)?<9BED?47781964:5675186.1:44;'-%*9134??A=*$*$+$468/5$$+&&&-979>70/+,++74'%'$/7%*6=?0,7'.9:::44<A<:6//6:B='$..0+:5%&%%10)%&.826?8@--@=;8&?CAEA>9;;FA2=6<;-,*7:;:@=A5I49D?:5=-1,:@=BB=58=:*9C5<?()3F@99>:AB;;<()>1=>A>;,0%%>166733<<;/)%%=B=7:23/46379',(/$%-%%%%%%%5//==>;4C=E8:?3,&;?G;44,36:GC4,:1%2./,+'.,/87636669:54$$(%'*5$$$$133467;D;;;:4*<>3093E?245@D,61<27+1+++6-96:::<-71)550,,0$$2%&&&%.*+*'#%$%%'+*--33&'6???J=@A5>AC-&6+-3<D@=5;@KNF:;(&&)+):A55B'.6++$/9=AA;G@@79236CG>B>A<55>3=<=@E?>HCB5<?=)/189=?A@@=;@,<((( -@bad94320-94dc-4619-bdf3-053740dbaeaf -AAAGAGATGTTTTACCCCAGGAAAACAGGAAGGATTACGTCAGGATCGTTTTTCGAACCGCTGCATGTACATGAAAGCGAGTGAGTCACTTTGGGAGCTTACGGTGTTTCTACATACCGTCTGTTTTCGACAGTTTCTCTCGGGAGTAATCTGCCATAAGTCTGGATAACTGGGGCACATTTGATACTCCGTAATAGCGATCAGCACCTCCACATACTCCCCTGTCCCCGACACGCTTGCCGTGAGTAAGGTTTTTCTATAGCCAACGCCCCAGTCTCATAGCTTCTTTCAGTACCCGATCATCAGTCCAGTGAGTTGTACTTTCTTACCAAAGTACCGCCGTAAAAAACCGGAAACGGTCTTGCCGCATTCAGCCCTTGCGTTCCTGGTCTTCTTCTGCCGTCAGACGAACAGGGCATTCAGTAGCCCGCCTGCGTATTACTTCCACTTCGTTTGTCGCAAAAACGCGAAACCATTATCAACCTTGGGTGTCGGGGCAGAAGCCACGACCTATGGAACGGTGTGACCAGCGTGCACATGTGCGCGGTATAACAATTGCACATCCTGTCCTGTCAAGCCAGCTCGAATTACAAATGGCACGGCAGTTTTTTGGCAGTGACGGTGTTGTCTGACAGAAATGCCCGTCAAAAAGCCAAGCGGCAGAATAACGGCAACAAAACGATTCGAAAAGTGGTACCTGATATAATCACACCATGCGATTGACAGAC -+ -=-&)4165.2383(,--,%-+$(310*.8$)50-'*(649-(.:0)129<?>'2$$$$2-57161%$--949;=B?>))$''&'&'.'(,.,,386=?A2*3%%B:55)&&$..++,22<AB?BAGFB=>64>@AD77(,;&(*)(0=<6+4-52&(),,9@716@=11$$+1<77$-(*+0.'419>*0/255:@=>=>8=9<D>=<B;A'''6--(7;?<>==?JF(5--+00****'*'$'$)%)*',(4@=?7-%%%&%%++68@AC;11,6+/%#-)CHC?FH65&*2-285((*3$&2)2&&.%,('%..4$&+&&(160*&$0)-%*($035553012-(**3;*++,*6&0.-(*$#&9=.A=6+/21%$$%(7<<01,'*9<8*)*,)/-/.47A9;?08,.+$+%$)$%&%&',(08<:288A,E<BCB>655649,,37=BHE?92:'(7:;<;9.,-+.'04**--&4')%(%&)03D5/>-12-+)&1+013#%/,.,&$%,.+).#%1%(%(&'(+21B0+'.%$$(+4*<.4255((602/321-3(()0'%((,*$&$$%##'&,50+%%(66)6%&('&&*$%4894<BAEC>68:0+5BECG48>?;<84@6A?D))EIH88KJB<=??>/*))7:01-8/318/7DD::C=EF/0C8974,%#-.('),++.>,.+'##$-,/+*)*&5%($#&%##))(..+)*))77 -@df89b955-2400-4adf-91be-adf7e99293a6 -GTGTGATTATATCGCGTACCACTTTTCGACTGTTTTGCTGCCGTTATTCTGCCGCTTGGCTTTTTGACAGGCATTTCTGTCGAACAACACTGCTCCTGCAAAAAACTGCACCGTGCCTTTGTCGGTAATTCGAGCTTGCTGACAGGACAGGATGTGCAATTGTTATACCGCGCCACATGCACGCTATTACAATTGCCCTGGTAAGAACTTTGCCCGACATGTCCAGATACGAACCCATGTTTTATGACAAAACAGGGGAATTAAGGTAATACGCGCAGGCGGGCTATCAGTCTGTTCGTCTGACAGCAGAAGAAGACCAGGAAATCAGAAAAAGGGCTGCTGAATGCGGCAAGACCGTTTTCCGGTTTTTACGGGCGGCAGCTCTCGTAAGAAAGTTAACTCACTGATGATCGGGTACTGAAAGAAGTTATGAGACTGGGGGCGTTACAGAAAAAACTCTTTATCGACGGCAAATGATGTCGGACAGGGGAGTATGCGGAGGTGCTGATCGCTGTACAGATATCCGCGTGCCCTGTTATCCAGACTTACATGGCAGATTAGCTTCCCGGAGAAAACTGTCGAAAACGAACGGGCATGAACACCGTAAGCTCCCAAAGTGATCACCATTCGCTTTCGCCGCCAGCTATGCAGCGAGCTGAAAACGATCCTGACGCATCCTTCCTGTTTTCCAGGTAAAACATCTCTTT -+ 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-GTTGCCCCGTTCAGTTACGTATTGCTGCGCGCACTCTCTATCGTCAGCAGCGTCAGATATGTATAAGAGACCAGTGATTATATCGCGTACCACTTTTCGACTGTTTTGCTGCCGTTATTCTGCCGCTTGGCTTTTTGACGGAGCATTTCTGTCAGACAACACTTTATCACTGCCAAAAAACTGCCGTGCCTTTGTCGGTAATTCGAGCTTGCTGACAGGACAGGATGTGCAATTGTTATACCGCGCATACATGCACGCTATTACAATTGCCCTGGTCAGGGCTTGCCCCGACACCCAATATCCAGATACGGAGCCATGTTTTATGACAAAACAGAGGTGGAAGTAATACGCGCAGGCGGGCTATCAGTCGCCCTGTTCGTCTGACGGCAGAAGAAGACCAGGAAATCAGAAAAAGGGCTGCTGAATGCGGCAAGACCGTTCCGGTTTTTACGGGCAGCGGCTCTCGGTAAGAAAGTTAACTCACTGACTGATGATCGGGTACTGAAAGAAGTTATGAGACTGGGGAGCGTTACAGAAAAAACTCTTTATCGACGGCAAGCGTGTCGGGGACAGGTAGTATGCCAGGGGGTGCTGATCGAGCAATACGTA -+ -&#$$%%%',,3*%1))&&%0%1498?;E62..$&2+06-'6>;?4-851@GB>:37..*%&,6@:;'2*7(1).CDDDGGFE>E7.(BCDF<<>?AA:489<EHD@<1%&&7@BUJCFDA;%//%%%()/<==IG?@3225%?BACE=>=:21&':5;960$$'*&+7?;;9,-;:889968,55488&*&)6,):,0<8:9-2$$.EML442BA84:DD+'<<>>$D9A::9>B@?=>=476:DDA;>:0/.-179:5-.23=138>?EFC?).5,$2418:9***/65>;7342#(..((>4881-+#&%#/1'&&::<;ADBB<GFD@:))-+0>=@?,:D??C??92295AFD,/./11;61:8<1=>FDFDD@60?0KED2;,7+3''('1-(1-4137A:BA;>0:42(>DBC9?4@-2//,.6<:=?C;B:@<)/1:GFNKEFC27?,(=B-3@C>8B**9:</?0<EMHBD>E@A@BLLE=99::6.2+2<ADDBC:@*:64=9C-;=:C<<<79<1&0?ACC8BA<@>DCC>?C9GHJF>:@9>57E9A>73A2,F%&';4+(<@D=@==;6'.'0,+,(%&-(/-,5**+:;8?@A:'- -@467ed196-ddc4-4852-b780-773b91fd58c5 -GTTCGTTCAGTTACGTATTGCTGCGCACGCGCACTCTCTGTCGTCGGCGGCGTCAGATGTGCCAGAGACAGGTCAGCAAGCTCGAATTACCGGCTCTTTCTAAAGGCACGGCAGTTTTTGGCAGTGACAGTGTTGTCTGATAAATGCCCGTCAAAAAGCCAAGCGGCAGAATAACGGCAACAAAACAGTCGAAAAAGTGGTACGATATA -+ 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fac91ddd-a0bf-4c28-a779-d30bff765453 -AAAGAAGATGTTTTACCCCGGAAAGCAGGAAGGATGCGTCAGGATCATTCCATGCTGTAACTATGCATGAAAGCGAATGGTGATCACTTTGGGAGCTTACGGTGAACGTACCGTCTGTTTTCGACAGTTTCTCTCCGGGAAGCTAATCTGCCATAGAGTCTGGATAACACGGGGCACGGTGATACTCCGTAATAGCGATCAGCACCTCCGCGTACTCCCTGTCCCGGCCGCTTGCCGTCGATAAAGTTTTCTGTAACGCCCCAGTCTCATAACTTCAGCGCACAGTACCCGAATGTCAGTCAGTGAGTTAATAACACAGGCTGCGCCGTAAAAACCGGAAACAGTCACCGCATTCAGCAGCCCTTTTTCTGGTTTGCAATGCCTACTTCTGCCGTCCGGACGAACAGGAGCGACTGATAGCCCGCCTGCGCGTATTACTTCCACTTCGTTTACATTCGTAAAACATGGCTCCGTATCTGACATGGGTGTCAGGGCAAAGCCCTGTTCCGGGGCAATTGTAATAGCGTGCATTAACCTGCGCGGTATAACAATTGCGCATC -+ -E6'-3,>C<;;?G?61887&*$*-)'%0-,/+-#,'117-'23*$'$#%%+&%%&($$((+0,%%1--02/-2:<<D>+0@=3-3)),,,&).*&(((&0')+0(&($%&).+,:96FED7:87*&'=@E@<3;5D/00**,-5<@AG@=GF6+')&/*3.693.&'&%-$)0)2*++1854-(),.3..00/.54,($-9'5044748$)$)*)3475=:**@>.045&%/0/43//777:01'()/E91($22361001+)*22-7&&--$$)##&$$$$($/,+5<**''$%0500:4-88/08=<**#&&&$*%'.,--+)04>@@ADABLO56?J@+'62%$274=.;5-8&4;6=8.....12%#&-//(0%&%#$#$%(-122--*&&&-$&&)%%,4326$7;DDC@=<.(08<E9<=>;)(*(-1143((+1513=A<<>>,#$$%(&$%366;81516CD87,,)$2&.16:;02@C:6+$06;@AABA;:2-&#$'-$(*+6$%$&%%23.414/B0,&$'$$#$&.47;,00:7339$&$'33<@+'6 -@ce62bc1e-78e9-4bc7-9e1b-b8dd3604f2b6 -AAAGAGATGTTTTACCCCGGGGAAAATAGGGAAGGATGCGTCAGGATCGTTTTCAGCTCGCTACACTCTTCTTCATAAGCAGATGGTGATCACTTTGGGAGCTTACGGTCGTTCGCCACCGTCACATTTTCGACAGTTTTCTCTCCGGGAAGCCATCTCTGCCATAAGTCTGGATAACGGGGGTGGTGATACTCCGTAATAGCGATCAGCACCTCCGCATACTCCTGTCCCCGACAACGCGTCGATAAAGAGTTTTCTGTAACGCCCCAGAGATCTGCATAACTTCTTTCAGTACCGTCATCAGTCCGGTGAGTTAACTTTCTTACCGAGCTGCCGCCAAAATAAAAAACCGGAAACGGTCTTGCCGCATTCAGCAGCCCTTTTCGGTTCTGGTCTTCTTCTGCCGTCAGACGAACAGGGCGACGGTAGCCGCCTGCGCGTATTACTTCCACTTCGTTTTGTCGTAAAAACATGGCTCCGTATCTGACGCTGGGTGTCGGGCAAAGCCCGATCGGCGAAGTGTAATGGCGTGTGCATGCGCGGCAACAATT -+ -1(%'18310;;D6//4-.$)//03+%#$&,%.02,)56,641+3?@:.(<?K;15-:93)**%%%#%&%(%%&)$$$***'',.)*-0138.....',3-3:;;56'(&$&&,1%%$$(+0,)%%%%+-14:;75=8;?<<99;&3&&$+*+'%)(+$0:6;;33786<B8:<70%%&#&'''%#$+*+$$):6;9:<><<>?AA=:6:A5::;7:-3+.*%75679;>I<0,(())(')%8:556=<5+-</2F;1.('&&*(((((((++).5)$$(+++')655;681:400+$&5<7?:8((<*0;<5CCDAD56>>>A9./1/)*>?BBB<<;()*''+/346789.1.17;$+8:AA789#?6:<*(**)*12668@:C.4?,@298<?BC2;>AFACB?>C@EC=<87,'-),,.),$%&*#04.555/343034))&%66=B;:<;,549?2))&%'/0//(.%($(,,6?A@=9<39.($"%%'%%%(+$)%0)+')%&%$$%,#&#$$$$/%%++.#%%&&$$%#-++2'-$%'%%,-.-/ -@6c74468c-23ee-4c55-a905-4ac27419f7ca -AATTGCCTGGTCAGGGCTTGCCCCGTTTTACCCATGTCGAATACAGGCCATGTTTTATGACCATAAACAGGAGGTAGATAACACGTAAGTATTATCAATCTCCCTGTTCGTCGACAGCGAAGAAAGACCGGAAATCAGAAAAAGTTTGCCAGATGCATGAATAATTCCGATTTTGCGGGCGGCGGCTCTGATAAAAAATTAACTCACTGACTGATCGAGATTTGCTGAAAAGAAGTTATGGAACACAGAACGTTACAAACTCTTTACATCTCGACAGCAAACGATGTCGTGGGGACAAGGGAAGTATGCAGGTTGTTTACAGTCGCTATTGCGGGTATCACCGTGCCCCTGTTATCCAGACTATGGCAGATTGCTTACCGGAGAGAAAGGCATCGAAAACGGACGGTATGAACACCGTAAGCTCCCAAAGTGATCACCATTCGCTTTCATGCATAGCTACGCTAAGATCGAGCTAAACAATCCTGACGCATCCTTCCTGTTTTCCGGGGTAAAACATCTCTTT -+ -%#%-$+)*%*0*&<3//./'+,-+&''&&$++/0**'*&&3..-&,456444434+&$$,*+1)-.%-&'%#(*+%#)&%%&$($%$$$#+%'-,;-.--)'0%%%044.)')(&$'('(,$)'&&546'*%(0+1&'+(&%%%#$&%$&''2(''#%%%'&#%"(%.+%/0.*$,$)/1')-%%&'%%&$((**(&$%(#$%'-,+1330/4'%$%$'').8-,564H:)%,')3823$&')$$$$%%'3272%'#((('&*+*&'+,1,3.)-$$%%'%$#&.&%'#$$&(7,,+-.5613996+*($&%#)%$&+&'%%&:%%,''+%2$($(09@==811$6598:>?91$$,'**(&02-/)$)$$-$#$%$(05:8*6)+(''*)%./,'+/*8-2/-'*/3-*)/4:7723+,&0/476/0%)4<63:168>@:A<567=73259-,(+%$(,%$)'(*&$&(%%$%$'%/$*((1-0:=2;<44<7A=?D@A<C>/3(-<98:==0C9:?/35;> -@401f4d56-6764-4256-b222-6960145f8306 -AAAGAGATGTTTTACCCCAGGAAAACAGGAAGGATGCGATCAGGATCGTTTTCAGCTCGCTACCCATAGCTATGCATGAAGGCGAATGGTGATCACTTTGGGAGCTTACGGTGTTCATACCGTCTGTTTTCGACAGTTTTCTCTCCGGAAGCTAATCTGCCATAAGTCTGGATAACAGGCACGGTGATACTCCGTAATAGCGATCTAACACCTCCGCATACTCCTGTCCCCGACACGCTTGCCGTCGATAAAGTTTTTCTGCTTAACGCACAGTCTCATAGCTGCCAGTACCCGATGTCAGTCAGTGAGTTAACTTTCTTACCGAGCTGCCCGCCGTAAAAAACCGGAAACGGTCTTTTACGCATTCAGCAGCCCTTTTTCTGATTTCCTGGTCTTCTTCTGCCGTCAGACGAACAGGGCGACCAATCAGCCCGCCTGCGCGTATTGCTTCCACTTCGTTTGTCATAAAACGTGGCTCCGTATCTGACATGGGTGTCGGG -+ ->1($/+-76><;2****)'.)>EBA./1=9;>3/923**51*>A>8>?A;;.734=,9##'##$$&%()07977:/)$%-*:>56;4+,7>:6<)***++..,+//.0<465/@1?)96<=:=>22CEJC=?D?;@CAR387%=9C9=&.1A9;<;<?;;;''%&%1628<>B76-&&39--'/ACB@;8:6223<;43/00-*5$&&'))*/$-$6298/348<@=?FEBAC::>6((6<=><:@=@;/4++CHPI?;2/++.56>2504748::@-'/%..'%)(,1.-3)'$()6<8/'3*.7;2A7<1178;/2*)&'/.,8=<1876'.59:?@@99999&'*)&-*0:<<610).4?9B>79326/552111185-,*%:@'699>=?@1,*(*)49=:3A;=B;1181,0,,+200''+)+**@AI>77-1,-'&&',.%,-.+,'*6:<?ABI>>E<;?AB06)1%+:>>B9B<9B.8-'',*021()*&(' -@632dd2fa-e55c-4f6a-9b26-7e68e582932c -AAAGAGATGTTTTGCCGGGAAAACAGGAAGGGATCGTTTTTCAAGCTCGCTGCATATGCATGAAAGCGAATGGTGATCGCACGGGAGCTTACAGTGTTTCATACCGTCCTGTTTTCATAGTTCTCTCGGGAGCTAATCTGCCATAGAATCCGGATAACAGGGCACGGTGATACTCCGTAATAGCATTAGCGCACCTCGCAGCACTCCCCTGGCTCCCCATTTTGCCGTCGATAAAGTGCAACGCCCCCAGTCATATAACTTCTTTCAGTACCGATCAGTCAGTGAGTTAACTTTCTTACCGAGAGCTACCGCCCGTAAAAACCGGAAACGGTCTTGCCTGCATTCGGCAGCCCTTTTTTCTGATTTCCTGGTCTTCTTCTGCCCGTCCGGGCGAACAGGGCGACTGACCCGCCTGCGCGTATTACTTCCACTTCGATTTTGTCATAAAACATGGCTCCGTGACATGGGTGTCG -+ -=1&(%5;==A?=7$25-/8+:030(7<./,%/7;?@FALFC?;<@6;C::=.$$$*6;@@:>9D=>91183+1@:4+>&%$%$(&'&222.($,&)77/(,1479:++=7803<1*)'&59=::'/(#''(&/<<=9C;';;/')$%%%%)'-=?>><7A.*($%26><43/.07=;;00.951&''%$%%%&./'6'(&%%##'&+*')(''2596/''()+-169=CBC<77,&2%$((+*-*+*'''&)##%%$$"%)4;><3)-0,)*)+,*&)**(*.-+59;=>78=D2.@>;620*-.++(567:9.)1?ADF>BA26.519378865+&&$&814*-$(+'%**))2A@><=5:8B=0(0756,,+79;>:0/*045))9,/0/((-,,9?GB68(/0/56;8BBA94+)((&*.3486%(&#$'%'$-2EFC;B25>AAD?:B4;FE45+1-.777-,(+)'&% -@6155ab1d-49b0-412b-b733-4e3032883ee3 -GACAGCCCATGTCAGATACGAACCATGTTTTATGACAAAACAGGAGTGGAAGTAGCCACGCGCAGGCGGGCTGTCAGTCGCCCTGTTCGTCTGACGGCAGAAAGACGGAAATCAGAGAAAAAGGGCTGCTGAATGCGGCAAGACCGTTTCCGGTTTTACGGGCGGCAGCTCTCGGTAAGAAAAGTTAACTCACTGACGGTGATCGGGTACTGAAGAAGTTATGAGACTGGGGCGTTACAAAAAACTCTTTATCGACGGCAAGCGTGTCGGGGACAGGGAGTATGCGGAGGGTGCTGATCGCTATTACGGAGTATCACCGTGCCCATTATCCAGACTTATGGCAGATTAGCTTCGGAGAAAAACTGTCAGAAAACAGACGGTATGAACACCGTAAGCTCCCAAAGTGATCACCATTCGCTTTCATGCATAGCTATACAGCGAGCTGAAAACGATCCTGACGCATCCTTCCTGTTTTCCCGAGGGTAGAAACATCTCTTT -+ -*2-)407;??>9B8:>E>2,+.<<B?EKJICDDFFC?@:6+.'$02??A707)9%%$$&$554-/>?/03<<:42,/44<CCEEFJIE84>8JEEAA?=;=:&'((0125<5@?:5(=?1/.*:<4E.=?CDHCDG49B:;9>=:9?>C0823J=8/$&$*:C?D-)FBF<>D5;6))(353,;047/*9<CAA@,%$%'''%?.27A<9:@;6072BHGA@B>E@?>9@1273>@<;'*12:A@F?GIFEBFE<2-0:<<$95H?8D.4BAF51=0-56GC>;>39?78?C:9AE@7A.-;6<?=B)*1)8*'<1123F=::'$$+=**GBD:6BADE.45:5:91+C>A0C5.1',/2-,->776)(BFGB?;=ED18>9977<>D?03356'<::<=HIGB?>98:54//5--'&',>CA=D9771933*%%.)3>:9<1.$%.742>>>AFFKDD>@D;<A?>ADFC@;J>9<*(%*)**'#,A9?@?GC6IGI -@ea1ef195-81f5-4c7a-8560-1aac0bf0a13a -AGAGATGTGTTTTGCGGGGAAAACAGGAAGGATGCGATCAGGATCGTTCAAAACTTCGCTGCATAGCTATCATGAAAGCGAATGGTGGTCTTTTGGGGCGCGGTGTTCATACCGTCTGTTTTCGGCAGTTTTCTCTCCGGGAAACTAATCTACCATAGAATCACGGATAACAGGGCACGGTGATACTCCGTAATAGCGATCAACACCTCCGCATACTCCCTGTCCCCGACACGCTTGCCGTCGATAAAGAGTTTTTCGCGCCCCGGTCTCATAACTTCTTTCAGTACCGATCGCCAGTCAGTGAGTTAACTTTCTTACCGAAGAGCTGCCGCCCGTAAAAAACCGGAAACGGTCTTGCCGCATTCAGCAGCCCTTTTCTGATTTCTGGTCTTCTTCTGCCGTCAGACGAACAGGGCGACTGATAGCCCGCCCGCGCGTATTACTTCCGCTTCCGTTTTGTCATAAACATGGCTCCGTATCTGACATGGGCTGTC -+ -3(570,*&*+/40$&%)@@)3J=3/A<9B8B:<93''3724B=8857,)&&%$$%*3448*(&&)$)3,,($../>>C@112+)(&&&,$"%&&&.012--0637=<9;;=987=?8;658)(#$&&%48B<<B:;*(#%%/%$.7=B<@2)79/0,+.,-3.6?CB?====:(.18;8=EB=?4<?7<:=DFC?B831./%&4588A;66=3377?6:8899:<92.,0&4%6:>@>ACBFGIDKK<&4;@AA;=)/545441%,24$:$$$$$4:89:04/10'&262-;%%'*,.2+<;23:FE?/(;>=<=>>:40/-%&5?E?CDBDE@>ADEG>?>FG01>@+B,3::H?=>A2<::8;@2(:$:<-,497>7@<=6)+-%*33563331+)138<B:<?>76;32.%*(&#%,/',)*--1/12:3,;?<A><B<=??8A*;?@(+209@744@117651$(5=@E:A;C5-F4MC=B@4176;933 -@8337f1bf-dee5-439d-995c-3b65b6ba25f4 -TACGGAGCCATGTTTGTAACCAAACAGGAGTGGAAGTAATACGCGCAGGCAGGCTATCAGTCGCGCCCTGTTCGTCTGACGGCAGAAGAAGACCAGGAAATCAGAAAGGGCTGCTGAATGCGGCAAGACCGTTTCCGGTTTTACGGGCGAAAAGCAGCTCTCCGGTAGAAAGTTAACTCACTGACTGATGATCGGGTACTAGAAAGAAGTTATGAGACCAGGGCGTTACAGAAAAAACTCTTTATCGACGGCAAGCGTGTCGCGGGGACAGGGGTATGCGGAGGTGCTGATCGCTATTACAGATGTCACACCGTGCGCCTGTTATCGAGACTTATAGCGGATGCTTCCCGGAGAAAAACTGTCGAGAAAACAGCGGACCCGGTATGAACACCGTGGCTCCCAAAGTGATCACCATTCACTTTCATGCATAGCTATGCAGCGAGCTGAAAACGATCCTGACGCATCCTTCCTGTTTTCCCGGGGTAAAACATCTCTTT -+ -&%&/20+889789;7$&02585711&&$0.?8;4*.70003&%%.-++>-'63/-36705.3%&AHHJHAA>5.&4)/0)&.69073(((;C;3()(24995.,32%&.1;CA=78/999;/26$%,/&(%)/:(-$)*/:4$$&+2,($$$$&&();:54$@'-+1&5/>;BAAD@C@<88C=--96:61++(+,(/43%%;6-):8@B?4++%))&%'(2?DAB>@1=/<4<BDF@F@GFE=8;;72341??>EBB6/3),*.7@;..*,).++($%,15==;74,0015..5,-,.*%)'%%+-%&*31)4'&),+((,.+&5''9:8A:96.8<&)26)$$',>D@7100-;:356+21*+$+*,-($&$%'3%73#$&1398><>=;47+065386CC@>@A:8>92.(()8)18BI9><=;-2232:910+',,%%589;8AC75;<00;=ABB;>=67987$',9@@JD(07&,-.*3375+316-6024 -@ed420a81-0710-489f-982d-cee487075d87 -GGAAAACAGGAAGGATGCATCAGGATCGTTTTCGAAACTAACATAATATATGAAGCAGATGGTGATCACTTCGGGAGCTTACGGTGTTCATACCGTCTGTTTCGACAGTTTCTCTCGAGGAAGCTAATCTGCCTAAGTCTGGATAACAGGGCACGGTGATACTCCGTAACGATCAGCACATCTTATACTCCCCTGTCCCCGACACGCTTGCCGTCGATAAAGAGTTTTCTGTAACGCCCCCAGTCCTCATAACTTCTTTCAGTACCCAAGTCATCAGTCAGTGAGTTAACTTTCTTACCGAGGAGCTGCCGCCCGTAAAGGCAGAGCAGTCTTGCGCATTCAGCTGCCCAGCCCGCTTTTTTTTTTTTTTTTCTGATTTCCTGGTCTTCTTTGCCGTCAGACGAACAGAGGGCAGCTAATGATAACCCGCCTGCGCGTATTACTTCACTTCGTTTTGTCATAAAA -+ -+-3<BA4/<<8:78,$#%%(1.7?7-+&-.:3/%&%#%&%%&&(()('%'')('$%118A+/;0-&.'$%&'%,/*+00/24.3469,/$%#(-/186-,0210<<7B=?=:6/2)(%4:6:1-.==6@;4&)$#'*+,&%'(/123/:/;*22(,30/1**5/0++&()))++&+-',(('%$((('01580409;>>=:56.-%$#$%389@CA6.EG5((9CHG<1+)*))3556660.7448<C@A<:6;B9BC.842&)(''$&&02*4821'--&-1(662%&#&+;47/%&*&&-.(/4:/77588507BD6&12+,)(()+,+&&%1$<:<1)2$,-,,0144421$)67DBBBJFECG>>8;3922*;=@./)%*9:5-$%'%"%&';@9@A;327.,0'(**,&$$#$&##'$$%4527874(2('&%&&(%)+).-9<>4)*4EC90<$$#%'& -@59335f9d-2638-4634-ba8f-e2f658dd126e -GTTCGTCTGACGGCGAAGAAGACCAGGAAATCAGAAAAGGGCTGCTGAATGCGGCAAGACCGTTTCCGGTTTTTACGGGCAGCAGCTCTCGGTAAGAAAGTTAACTCACTGACTGATGATCAGGTACTGAAAGAAGTTATGAGACTGGGGGCGTTACAGAAAAAACTCTTTATCGACGGCAAGCGTGTCGGGGACAGGAGTATGCGGAGTGCTGATCGCTATTACGGAGTATCACCGTGCCCTGTTATCCAGACTTATGGCAGATTAGCTTCCCGGAGAAGAAAACTGTCGAAAACAGACGGTATGAACACCGTAAGCTCCAAAGTGATCACCATTCGCTTTCATGCATAGCTATCTTTGACGAGCTATTGATCCTGACATCTTCCTGTTTCCCGGGGTAAAACATCTCTTT -+ -AJGB>3@7MCG-3:''955,26,/)1//9E;B33=;3**7@9:8)'''/049(0DEFFDEH>IFB&*&.<=@6?AA;>=+'5/*8?B>AF28?664<98?DB>?<DA86<GA==4,GE3+/&.(;>?@BAJ9/98=;GA?C@HH;9*-85<68=A@;;76A7<D>:2222>BCB@=<044=</')A:6C)2??;319366A@868,-%'C=>>?;6E66;;>:1A16/98.&.-34;C>ECDF(DCB&&B8>>''(8@8:=<<>@:D3<=>*06)-0&&+&9CCE@B92;4;8715/628$'5:+..7;6%078::2=<2==>412,+)A6==>DE>98JK@@6/+6/4869;700((-3+(&$)%&$#$))346/0,+$(4;=9;<B@?E*.>$.,,9=?HD@<8>;<IEC -@e0998300-6336-4a3d-bb92-51572c44c417 -GGAAAACAGGAAGGATGCGTCAGGATCGTTTTCAGCTCGCTGCATAGCTATGCATGAAAGCGAATGGTGATCACTTTGGGAGCTTACGGTGTTCATACCGTCTGTTTTCGACAGTTTTCTCTCCGGGAAGCTAATCTGCCATAGAATCACGGATAACGGGCACGGTGATACTCGTAATAGCGATCAGCACCTCCGCATACTCCCTGTCCCCGACACGCTTGCCGTCGATAAAGAGTTTTCTGTAACGCCCCCAGTCTCATAACTTCTTTCAGTACCCGATCATCAGTCAGTGAGTTAACTTTCTTGCGAGAGCTGCCGCCCGTAAAAAACCGGAAACAGGGTCTGCCGCATTCAGCAGCCCTTTTTGCGGTTTCCTGGTC -+ -0=/:A7-*9E<E@=8=7?20@>CDC9<<DCB);34@??ABGGH:C?HBC?>?@=>?<C4;:88?=3;AE/*C578:>9<;1<87477*.>AC=F;<<B>3$$(57;F47==8=5CEJ@<8%5&:$%%%$)&->B=AB>@=+'5&&&+)&&?BDDJHF53<<;KIHFHE;2A,?=@BA549:7/+.@*:>$:?02-/((/3@69/64=?B?><8:176))1AABEA<@B=EA8'&5,6K>B84<>@FHKGE;553'0-@---,+3289=(:2=DGIG@BC=C;4C<=9<96966=C?21)*0;763$2/'(:?CCACDA?==@@EIIEG;A</1+10-&*'$&&%/8<=@:<-.$&'$&&%%%%%%+$&$&15<.04'''% -@b45a17f1-0345-4fb6-a33c-200285e4e92d -CAGGAAATCAGAAAAGGGCTGCTGAATGCGGCAAGACCGTTTTCCGGTTTTACGGGCAGCTCTCGGTAAGAAAGTTAACTCACTGACTGATGATCGGGTACTGAAAGAGTTATGAGACTGAGGCGTTGCAAGAAAAAACTCTTTATCGACGGCAGAAGCGTGTCGGGGACAGGGGAGTATGCGGAGGTGCTGATCAACTATTACGAATTATCACCGTGCCCTGTTATCCAGACTTATGGCAGATTAGCTTCCCGGAGAAAACTGTCGAAAACGGGCGGTATGAACACCGTAAGCTCCCAAAGTGATCACCATTCGCTTTCATGCATAGCTATGCAGCGAGCTGAAAAGCGATCCTGACGCATCCTTCCTGTTTTCCCGGGGTAAAACATCTCTTT -+ -83>:)4;03>,9)2,':A?;==688?77C19=<<D=A61=?EB*5-4><=-.?367'%:AD<:;7<7//-0.+8-.CD<>965=GH@DD?=<3-B10;<;;@??+877@>:/./0CA;.<&0,.&-0$,%''79FDE?<E?HJID:=95.,.&0$&&8==J5,A',<@I=;>8::29BD>>?4987FAA?>=82:&&/04990,1%&%,31,.275?5::=A)A>@..D9CA77657;B:G7BCB?@AFE7=B?@EB.3D<ACA=A@BIJA;$+$8'-8@CA>><1-2.2'('+62>:+,+5;<18D<=@DK:</.@@<B@>BJ=85DA<C73301700%000169%(.;@++-CJ4=>B=67=>B?BMC;<SC7::%'/29BEJIBE@C?4FHP -@1ce56370-4094-46c7-9d23-b6e0d6c32099 -AAAGAGATGTTTGCAGGGAAAACAGGAAGGATGCGATCAGGATAGTTTTCATCGCTGCATAACTATGCATGAAAGCGAATGGTGTGATCACTTTGAGGGCTTGGTCGTTCATACACCAAATCTGTTTTTCGACAGTTTCTCTCCGGGAAGCTAATCTGCCATAGAAGTCTGGATAACAGGGCACGGTGAAATGCTCCGTAATAGCGATCAACCTCCACATACTCCCTGTCCCACGACACGCTTGCCGTCGATAAAGAGTTTTCTGTAACGCCCAGTCTCATAACTGGCACAAGGTACCCGATCATCAGTCGGTGAGTTAACTTTCTTACCGAGAGCTGCCGCCCGTAAAAAACCGGAAACGGTCTTGCCGCATTCAGCAGCC -+ -J5'&-97..:=.$&%/.,/5?<1+=@=>:4.%'.$$&3--1,&(*0?>-/')+*./7</5,,/68//=89117*3<66<</2-).,'+?0///*)$%%$%%%$&)%&1,*$%&$&%8**)':%,4554,43/506>CC3<2E6F,0C><?BA@=>@>879)%/$(&$6;4;==7443->0.0/2+/-*,-($"&(29::;<935521,=&&*,25:%;23.,89>8:933:8'.6>@@>8:??24/(;B??>BD/,)<89IB(.%,++,',.0)169>A&&*)*-'&&).$&&'.5=EA=924*%%$'0;&-4:1EGED95;?>966+;;?9)&/94+%-56:C<=GM@=<:;C2518*8&+-../4>A8B?;-1/4'4$$$ -@f4d1033e-fb7b-45f1-bfc0-752c8b7c7383 -CTTGCTTCGTTCAGTTACGTATTGCTGCGCGCGCACTCTCTCTGGTCTCGTGGGCTCGGAGATGTGTATAAGAGACAGATTGTTTAGATATATAGACGATCTATTCAATAAAATAAAAGAACAAGAATCTATTATTATTACATCCTTAGATCCTGATTACGCTTACCCAAATAATGAAAAGAAAGCAAAAGTTCAAGTTTACCTTAGTTGTAATAAGGAATCAGATTCACAAACTGACATATCAATGAAGAACAAAACCCTATTGATACTGACGATGACTGCTTCAGTGAGATAAAAGAATTTATATCAAAAATATGAAACAACTCCACCTACAAATCATAGCGCAATGACTAAAGACAATTATAAAATTTAACATAATGCCGTGCATAATTGCACAAGAAACGCTGAACGCCCAGGTCTGACGCGCAGACACCGCAAAAGAGATGTTTTACCCAGGAAAACAGGAAGGATGCGTCAGGATCGTTTTCAGCTCGCTGCATAGCTATGCATGAAAGCGAATGGTGATCACTTTGGGAGCTTACGGTGTTCATACCGTCTGTTTTCGAAGTTTTTTCTCTCCGGGAGCTAATCTGCCATAAGTCTGGATAACAGGGCACGGTGATACTCCGTAATAGCGATCAGCACACTCCCGCATACTCCCTGTCCCCGACACGCTTGCCGTCGATAAAGAGTTTTTCTGTAACGCCCCCAGTCTCATAACTTCTTTCCAGTACCCGATCATCAGTCAGTGAGTTAACTTTCTTACCACCGAGAGCTGCCGCCCGTAAAAACTGTCTCTTATACACATCTTGAGCCCACGAGACCAG -+ -%$$&25756F'8/=A@:CAC=?A=<<5,1))'%%13<43&2/-05223<>FCGGB1<181:=D=-?@A;''..+9.&(%%,9ABHEBAGGEAFIFEA<2(?*@@CDKLADG>D7@BB(31>:CF1DA44/)')'&&$-11.3((/(++4=66999::@F<;>C?>7;=CFC@9:C?<69-&9:;D<HH:7A@@=BDCED6.$$$'(03;.*69<@B8C7D:A;85,1(&&(**%&%(2.?95C==@DF0=;<;FHI>2'%$$'''';;==C7?9:93*&0&&1)34.A4:@F=:;5%)'++0?@4C;<AB;<4)).('<@>,.>@6;+A=:4>=>??@:6*?B;@JNC?>=?9:*(8B:;8EB8FKAFGIIGF50/453/#%''&%$.,,,//417((%87055:8:3.'$)0'%)$&%)-+.)($.''@<?9@<<A@-$*8;4;=@@H;*&((&.3,20-.,:C?C@A=83><;A9BD@8<@NHO,0'=9::CCIBG4;6CA?<22DA68>86<;544-%,<A>4A<<CEE/4A05443.-&'?280418<=977>;8B@G6,&$$%)1IF>.178C5-,-,,6<:@?<?EACB-/2241/'%(6>>>=8?3+/+.+355;7''=8.''441'$$:=8<935.4&$'09;=D=<;7988'*::;=:<?C?422**17;<>?@8:AFF?,49HLSGE?<+0;<@;B@>B;>6.73?.@CC<>B?@C>.2?3?9><9887A5(85263./<9:CHD=?789B;;9300'CAAA&9:DE=DEBGHB96-..;=??;<=@7225<==(:244,'&&145>5+/'4(%'%% -@ae0853da-5e92-45c3-b88b-20fed2a4964f -AAAGAGATGTTTTACCCCAGGAAAACAGGAAGGATGCGTCAGGATCGTTTTCAGCTCGCTGCATAGCTATGCATGAAAGCGAATGGTGATCTTTGGGAGCTTACCAGGTGTTCATACCGTCTGTTTTCGACAGTTTTCTCTCCGGGAAGCTAATCTGCCATAAGTCTGGATAACGGGGGCACGGTGATACTCCGTAATAGCGATCAGCACCTCCGCATACTCCTGTCCCCGACACGCTTGCCGTCGATAAAGAGTTTTTCTGTAACGCCCCAGTCTCATAACTTCTTTCAGTACGATCATCAGTCAGTGAGTTAACT -+ -.($+)('7;JJE=;9;;,*??;IGH*&AIBJ@><53.).:0>CCAFAPLM84?7?@B0&,2<.58?;67=?D<?@=3A@854=9*/.0*&'#('%)0++0004%0&,*94B=D755AD=7B=CCAA8:=?61<ADG8@D=E6D49<;10@BDF?C@BDD:C<=5-9.1460*+1$*43?;?BDDGFC1,%'=867;<:2@:.($<?=C3===7?*7259;;8:22:=HKG7975<2/11))+);>@C?JR=%:;BGZREC>&=>?@=ED@0/18<+9*,:/-8<;>?8:28=2066?F8893812+2,2(=@@88?@ -@c127e70a-405f-46c0-ae0b-e647ef99c3af -AGTTATGAGACTGGGAGCGTTACAGAAAAAACTCTTTATCGACGGCAAGCGTGTCGGGGACAGGAGTATGCAGAGGTGCTGATCGCTATTACGGAGTATCCTGCCGTGCCTATTATCCAGACTTATGGCAAGATTAAGCTTCCCGGAGAAAACTATCAAAACAGACGGTATGTTTTCACCATCCAGCTCCCAAAGTGATCACCATTCGCTTTCATGCATAGCTATGCAGCGAGCTGAAAAGAAAACGATCCTGACGCATCCTTCCTGTTTTCC -+ -''+039A>BD56<@D/9>FLGHAD?47;<D9<66(*/>@@@BF=?@@?::8AB:<+-/:@:9;>1<574/.)3/-:?98IG2),(-888;CA0271=8./8////-2/430-,/0%%:-/=?IHA<,/0&('$$%()2113176')-+79>,&(%$$$'..,',')$&)&%.%%%%%%$%%##&)$''(+*()&,4587A@@@GJL;;))8719BDF</-539@B>844311:1//10)&'/00+<<C9:>6=56-.:..7/.(-@?>AKH*. -@9a0e90b3-3c3e-4843-95cb-b1596828ed6f -AAAGAGATGTTTTACGGGAAAACAGGAAGGATGCGTCAGGATCGTTTCAGCTCGCTGCATAGCTATGCATGAAAGCGAATGGTGATCACTTTGGGAGCTTACCTGGTGTTCATACCGTCTGTTTTCGACAGTTTCTCTCCGGGGAAGCTAATCTGCCCGCCAAGTCTACGGATAACAGGGCACGGTGATACTCCGTAACGCGATCAACACCTCCGCATACTCCCTGTCCCCGACACGCTTGCCGTCGATAAAGAGTTTTTCTGTAACACCCCCAGTCT -+ -BE1%7>?A=FFE7-5'.25855*%5410/:48:;5371>B85@9@=<836>;A648+,2/5+&@:05E<>A><?C=$$,$%-6;92@34@@6'+-$)%--.%)$)':,=9=311@C>;DDDBB@:765638DE)63<B85*+,)*('&&$%/00/*,,%$%-.09<22/?CBD:7-(8;AB:;=BGA?;401+0&$$$#$%53->$'73;<<<?9<5=><@8=39,9<JG/$$$5F=@FC)331?D<>?IK4=5AMJPH<3+)'-.30FIGA0.701' -@162b5056-1cc5-40d8-a1de-6bebe548bc27 -TGTTTTACCCCGGGAAGCAGGAGAGGGATGCAATCTTTGCAGGATCGTTTTCCATTTTGCCCGCTAGCTATGCATGAAAGCGATGGTGTGATCACCGGGGAGCTTACGGTGTTGTCCACCGTCTGTTTCGACAAGTTTTCTCCGGGAAGCTAATCTGCCATAAGTCTGGATAGCAGGGCACAGGTGATACCGGCAGCGATCGCTTCCTCCACGCCTCCTGTCCCCGACACGCGCCGTCGATGAAGTTTTTTCTG -+ -%,68@8/-778/-((*),*;0/$&36882,/#$%$%)00-,6;<9?@JCDE34'())(&$''#$,,(1+?<?C:13--%--%(($&%%$'&%+%$($(1/-.454=?..1-2*$%$&'-/,+.$&##$0338**25:H?<-&8-2C8:-8542,))$)*%',+25?89;@)9%)%*+'&$'$(18=;.&&&#&,&,,.,'6%#$$'(-7;%2**+-','%5<BD@;76,**)'-(/3740*'($.49>=95*$' -@c506ed82-9194-4814-9a9d-7532715b5f51 -AAAACTCTTTATCGACGGCAAGCGTGTCGGGGACAGGGAGTATGCCCGGAGGTGCTGATCGCTATTACGGAGTATC -+ -(+;;<;.BDGD<BEGC<:;99/63B73@146<8,(A?</;A0+6$335;:7/578@D.&6''4--5:F9;)9B50; -@d4db67e9-1787-4f1f-8017-f6e815022fde -AAAGAGATGTTTTACCCCGGGAAAACAGGAAGGATGCGTCAGGATCGTTTCAGCTCGCTGCACTCAACTATGCATGAAAGCGAATGGTGATCACTTTGGGAGCTTACGGTGTTCATACCGTCTGTTTTCAGCAGTTTTCTCTCCGGGAAGCTAATCTGCCATAAGTCCTGGATAACAGGGGCACGGTGATACTCCGTAATAGCGATCAGCACCGCATAC -+ -<8%27.857<?IA@GHA;%+8(,?8*&=9:8ED6,,5:=2:.G?<?:CC*-0').3-/7/10**+..692/10624/-,25789>4:E?>?B<=??@7=@69885'8&.=>B?C77=A?>?ABCEBID71031;15IE@F9>,@=DKJ?1@CIG<ABDFD5<;;6226@@CFDCB78:7;?BJA@AGF>>99@=B>:BC:4@?=-%8?28;.:3=87;< -@aba91300-4618-4b54-beb5-01aefe1e0af8 -CGCTATTACGAAGGAGTATCACCGTGCCTGTTATCAGACTTATGGCAAGATTAGCTTCCGGAGAAAAAACTGTCGAAAACAGACGGTATGAACACCGTAAAGCTCCCAAAGTGATCACCATTCGCTTTCATGCATAGCTATGCAGCGAGCTGAAAACGATCCTGACGCATCCTTCCTGTTTTTCCCCGGGGTAAAACATCTCTTT -+ -42@A=BA<(/%$&*#&8-)<353-B3=<>>A@*%?458331.2'+3#%)+0.*4899%+/4-///((*)'()*337731,)0,>)1420))/==5678785(10)0-12-/=977:<75&99,$%):@B;:9:(),),(8221*:;00:2144KH=A6:**0$&%4355:;?C?8:D?=<C==8<?9&+7=>@C@86@;>A??64 -@e3986483-5f5e-480a-81bc-cfaac9c8678e -GCTATTACGAATTATCCACCGTGCCTATTATCAGACTTATGGCAGATTGGCTTTGGAGAGAAAACTGTCGAAAACCAGACGGTATGAACACCGTAAGCTCCCAAAGTGATCACCATTCGCTTTCATGCATAGCTATACGGCGGAGAGCTGAAAACGATCCTGACGCATCCTTCCTGTTTTCGGGGTAAAACATCTCTTT -+ -(?A@=CE-3()(49))6,69>H>::/(79,%3(0:&&%*3)-0/23-5$)**+&6;<),%:CC=5?7562**'%%61>=?:;FDF@?:4>56>?3/(<;)0*02/36<<;AAABCDFE::JIF<9;5:4<:?>@-)'3'.1$&&$&,;:00C?'4=>((,@D9H?<B<>@B<;=HG=<L(=()(&7<>@=F<;CB>D?= -@7a97d860-e33a-4e27-b5be-c4754a2eb907 -ATTACGAAGTATCACGTGCCCTGTTATCCAGACTTATGGCAGATTAGCTTCCCGGAGAGAAAACTGTCGAAAACAGACGGTATGAACACCGTAAGCTCCAAAGTGATCACCATTCGCTTTCATGCGCCTTGGCTATGCAGCGAGCTGAAAACGATCCTGACGCATCCTTCCTGTTTTCCCGAAGGGTAAAACATCTCTTT -+ -?>A?'-$%+?'%8$03F;;;=8*57>((?3:E?E?65%,0,.,B>77?AA6<G<9C(,):0IGAD=;AEIJLC@'?3A+/68966>9?<>??:</:<-.'(%32228@;:=CGDA>78:@97424%%$'%')460((8,:;1/4////@;5;?@//5896:.+?:<ACA>@KEA@LD=C22.+01849?D<>@;A=<K5/ -@cc6e152f-3be2-4154-95c1-265c4f77a7ac -TACGGAGTATCACCGTGCCTGTTATCCAGACTTATGGCAGATTAGCTTCCCGGAGAAAACTGCTCCAACAGACGGTATGAACACCGTAAGCTCCCAGAAGTGATCACCATTCGCTTTCTCATGCATAGCTATGCGGCGAGCTGAAAAGCTGATCCTGACGCATCCTTCCTGTTTTTCCCGGGAGTAAAACATCTCTTT -+ -,*635,44()6,87.6'66=(@;0**E=DFCL?77-56732,/(-./1-.//17&(5EE;:)')(6,,4=8>C29;5>8832,>>459;+;;)-(+$%$*77;6CAABDB?-0*+,(&$+&**8:85=??@))?%.7+*4/+(*.'($#%,,++4;EBB:B>78=8<=@GBDCGB@5;A+1<$6:EGDAG;:>>@@?H -@749ba682-4ec2-4367-8bb3-51878f06992d -CCGGGAAAGCGGAAGGATCGTCAGGATCGTTGCTACAGCTCTGCTACATATGCATGAAAGCGAATGGTGATGCTTTGGGACTTTACGGTGTTTCATACCGTCTGTTTTCGACAGTTTTCTCTCCAGGGAAACTAATCTGCCAGCAAGTCTGGATAACAGGG -+ -#$$(+('&%,$)5;:8/&(,121165++.-/$$(%)(%#%'#$$$$&&%$%(3/1<222(666:=8<47/&$&)),&'&',-/.39=B>B?=-89;=>=;;;335686E;=9499=PA@-8<%/'/*+,)$77=7/-5//.-&(()**7',./102,&,&' -@3d6bdcab-ef5c-4ff8-a928-23066fb4e887 -CTGTTATCAGACTTATGGCAGATTAGCTTCCCGGAGAAGAAAACTGTCGAAAACAGACGGTATGAACACCGTAAGCTCCCAAAAGTGATCACCATTCATCATGCATAGCTATGCGGGCAGACTGCGAAAACGATCCTGACTCCTTCCTGTTTTCCGGGGTAAAACATCTCTTT -+ -12551)$>,,/,,,AE??>==?6/.'''-8>B03<+,,-=CA@<A@<A98=<17581:*0<BC66@AA<>;;/09:6470999-%171+98==8<;6#'36;AC;7:689<<89%*./(&$++$-+--<-;=>55:4;*%&%*%/454@CAHA/318?G?4599=9?DEA@?E -@0b41ea60-ea37-43ef-a912-260c4d33a356 -CTGTTATCCAGACTTATGGCAGATTAGCTTCCGGAGAAAACTGCTTCGAAAAACAGACGGTATGAACACCGTAAGCTCCCAAAGTGATCACCATTCGCTTTCATGCATAGCGCTATGCAGCGAGCTGAAAACGATCTGACGCATCCTTCCTGTTTTCCCGGGGTAAAACATCTCTTT -+ -=B>B3+++7-2-))%&.%,3**749689:=1B0.3&)(-'$$%#%(*(((('$,)+(/+,,/48:>;62+7:)*.<;9>@DE75@?<?GFGD@DDA$$=>;>?::>-043+).2?;<(&551.;><:8G@6E@<6@7<6@1CE78BDB>?=?57I@'-G3;@B=>@F@?8<?>794- -@cd8d2944-a807-434b-92d5-bfa925697c85 -GTTATCCAGACTTATGGCAGATTAGCTTCCCGGAGAGAAAACTGGCATGAAAACAGACAGGTATGAACACCGTAAACTCGGTGATCACCATTCGCTTTCATGCATAGCTATGCAGCGAGCTGAAAACGATCCTGACGCATCTCCTTCCTGTTTTCCGGGGTAAAACATCTCTTT -+ -8?>>%%06/B@FEFG7=854742')9<=+3B9:<98%;<>3..-(&$*/13,*;8;1+&59ADB55<94<<:;99(&)+#&62-'('668:7855;=C><24B=>==>;B<:30=;=1;9575IF9A=E55<:@?GC;77=069<=25152/56)/,45?>@BE162;>:9DCE -@a492dd23-2c03-4d9b-a606-dee7268bd4fa -AAAGAGATGTTTTTGCGGAAAACAGGAAGGATGCGTCAGGATCGTTTTCAGCGCTATAGCTATGCATGAAAGCGAATGGTGATCCTTTGGGAGCTTACGGTGTTCATGCCAATCTGTTTTCGACAGTTTCTCTCCGAGGAAGCTAATCTGCCGCAAGTCTAGTTAAC -+ -F:&-/77;:@??=8%%$(#'+()%+9.99AB?==<<7/;;4/;;B>?-+(*2%%&0-1-=5;99GD=88>9>??=IC2:B?:%%*#*-&.1**,--;A::8BID?4&&%8'(<AE3??;C@>B64>:;31&*,(5('7A04.>@CC;AA7%1-1%&-/5'%*%-+,/ -@4a58265a-1d25-47a1-b851-e7687203734f -GGGAAACCCAGGAGGATCGTCAGGATCGTTTTTTCAGCTCGCTGCTATGTATGCGCTGAAAGCGAATGGTGATCACTTTGGGGAGCTTACGGTGTTCATACTGTCTGTTTTCGACAGTTTTCTCTCCGGGAAGCTAATCTGCCATAAGTCTGGATAAC -+ -)**%&&%5'%)*$..5%$$,70?B?:>?GBLB<0))%&'-78>.11/$$+($&$&%***2),=88=@,1A=:3<25;<959E;.9?BB*A<CCHBBB==BCC>=B>B9?LL;AA74C>CNEDF<C%?7<D78.=>C=4=?@BB9@>>2-A14:C;..5 -@f9a56724-1fa4-4807-bacc-f0a85587afd7 -GAACACCGTAAGCTCCCAAAGTGATCACCATTCGCTTTTTCATGCATAGCTATGCAGCGACTGGCGATCCTGACGCATCTTCTGTTTTCC -+ -414===BA;3-.21$+&')'%-20-,((+6:57(*+,139@@?A534546/24022**)$$$#&(--++-7<+6*.*(())(,-03<:(, -@e525f31a-e4d6-4fe6-a703-7038efa2f178 -GCTATGCAGCGAGCTGAAAACGATCCTGACGCATCCTTCCTGTTTCCCGGGTAAAACATCTCTTT -+ -;B@E::0+5511=2122@>52((''*<G=E:?A45:79$=JFCC?AJG*024<>HECB@C@?KHI -@eeef3ccf-2188-4382-8399-a9442bbbf40a -GCTATGCAGCGAGCTGAAAACGATCCTGACGCATCCTTCCTGTTTTCCCGGGGTAAAACATCTCTTT -+ -@=:3335937))43378KC?<?A<>CKMEH?BC55=4C>?KDFCLC4@G363877800+7<=;3;;>
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/bwa-mem-mt-genome.fa.fai Tue Sep 01 03:08:24 2020 -0400 @@ -0,0 +1,1 @@ +gi|251831106|ref|NC_012920.1| 16569 31 70 71
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/ref.fasta Tue Sep 01 03:08:24 2020 -0400 @@ -0,0 +1,2 @@ +>NC_045512.2 +ATTAAAGGTTTATACCTTCCCAGGTAACAAACCAACCAACTTTCGATCTCTTGTAGATCTGTTCTCTAAACGAACTTTAAAATCTGTGTGGCTGTCACTCGGCTGCATGCTTAGTGCACTCACGCAGTATAATTAATAACTAATTACTGTCGTTGACAGGACACGAGTAACTCGTCTATCTTCTGCAGGCTGCTTACGGTTTCGTCCGTGTTGCAGCCGATCATCAGCACATCTAGGTTTCGTCCGGGTGTGACCGAAAGGTAAGATGGAGAGCCTTGTCCCTGGTTTCAACGAGAAAACACACGTCCAACTCAGTTTGCCTGTTTTACAGGTTCGCGACGTGCTCGTACGTGGCTTTGGAGACTCCGTGGAGGAGGTCTTATCAGAGGCACGTCAACATCTTAAAGATGGCACTTGTGGCTTAGTAGAAGTTGAAAAAGGCGTTTTGCCTCAACTTGAACAGCCCTATGTGTTCATCAAACGTTCGGATGCTCGAACTGCACCTCATGGTCATGTTATGGTTGAGCTGGTAGCAGAACTCGAAGGCATTCAGTACGGTCGTAGTGGTGAGACACTTGGTGTCCTTGTCCCTCATGTGGGCGAAATACCAGTGGCTTACCGCAAGGTTCTTCTTCGTAAGAACGGTAATAAAGGAGCTGGTGGCCATAGTTACGGCGCCGATCTAAAGTCATTTGACTTAGGCGACGAGCTTGGCACTGATCCTTATGAAGATTTTCAAGAAAACTGGAACACTAAACATAGCAGTGGTGTTACCCGTGAACTCATGCGTGAGCTTAACGGAGGGGCATACACTCGCTATGTCGATAACAACTTCTGTGGCCCTGATGGCTACCCTCTTGAGTGCATTAAAGACCTTCTAGCACGTGCTGGTAAAGCTTCATGCACTTTGTCCGAACAACTGGACTTTATTGACACTAAGAGGGGTGTATACTGCTGCCGTGAACATGAGCATGAAATTGCTTGGTACACGGAACGTTCTGAAAAGAGCTATGAATTGCAGACACCTTTTGAAATTAAATTGGCAAAGAAATTTGACACCTTCAATGGGGAATGTCCAAATTTTGTATTTCCCTTAAATTCCATAATCAAGACTATTCAACCAAGGGTTGAAAAGAAAAAGCTTGATGGCTTTATGGGTAGAATTCGATCTGTCTATCCAGTTGCGTCACCAAATGAATGCAACCAAATGTGCCTTTCAACTCTCATGAAGTGTGATCATTGTGGTGAAACTTCATGGCAGACGGGCGATTTTGTTAAAGCCACTTGCGAATTTTGTGGCACTGAGAATTTGACTAAAGAAGGTGCCACTACTTGTGGTTACTTACCCCAAAATGCTGTTGTTAAAATTTATTGTCCAGCATGTCACAATTCAGAAGTAGGACCTGAGCATAGTCTTGCCGAATACCATAATGAATCTGGCTTGAAAACCATTCTTCGTAAGGGTGGTCGCACTATTGCCTTTGGAGGCTGTGTGTTCTCTTATGTTGGTTGCCATAACAAGTGTGCCTATTGGGTTCCACGTGCTAGCGCTAACATAGGTTGTAACCATACAGGTGTTGTTGGAGAAGGTTCCGAAGGTCTTAATGACAACCTTCTTGAAATACTCCAAAAAGAGAAAGTCAACATCAATATTGTTGGTGACTTTAAACTTAATGAAGAGATCGCCATTATTTTGGCATCTTTTTCTGCTTCCACAAGTGCTTTTGTGGAAACTGTGAAAGGTTTGGATTATAAAGCATTCAAACAAATTGTTGAATCCTGTGGTAATTTTAAAGTTACAAAAGGAAAAGCTAAAAAAGGTGCCTGGAATATTGGTGAACAGAAATCAATACTGAGTCCTCTTTATGCATTTGCATCAGAGGCTGCTCGTGTTGTACGATCAATTTTCTCCCGCACTCTTGAAACTGCTCAAAATTCTGTGCGTGTTTTACAGAAGGCCGCTATAACAATACTAGATGGAATTTCACAGTATTCACTGAGACTCATTGATGCTATGATGTTCACATCTGATTTGGCTACTAACAATCTAGTTGTAATGGCCTACATTACAGGTGGTGTTGTTCAGTTGACTTCGCAGTGGCTAACTAACATCTTTGGCACTGTTTATGAAAAACTCAAACCCGTCCTTGATTGGCTTGAAGAGAAGTTTAAGGAAGGTGTAGAGTTTCTTAGAGACGGTTGGGAAATTGTTAAATTTATCTCAACCTGTGCTTGTGAAATTGTCGGTGGACAAATTGTCACCTGTGCAAAGGAAATTAAGGAGAGTGTTCAGACATTCTTTAAGCTTGTAAATAAATTTTTGGCTTTGTGTGCTGACTCTATCATTATTGGTGGAGCTAAACTTAAAGCCTTGAATTTAGGTGAAACATTTGTCACGCACTCAAAGGGATTGTACAGAAAGTGTGTTAAATCCAGAGAAGAAACTGGCCTACTCATGCCTCTAAAAGCCCCAAAAGAAATTATCTTCTTAGAGGGAGAAACACTTCCCACAGAAGTGTTAACAGAGGAAGTTGTCTTGAAAACTGGTGATTTACAACCATTAGAACAACCTACTAGTGAAGCTGTTGAAGCTCCATTGGTTGGTACACCAGTTTGTATTAACGGGCTTATGTTGCTCGAAATCAAAGACACAGAAAAGTACTGTGCCCTTGCACCTAATATGATGGTAACAAACAATACCTTCACACTCAAAGGCGGTGCACCAACAAAGGTTACTTTTGGTGATGACACTGTGATAGAAGTGCAAGGTTACAAGAGTGTGAATATCACTTTTGAACTTGATGAAAGGATTGATAAAGTACTTAATGAGAAGTGCTCTGCCTATACAGTTGAACTCGGTACAGAAGTAAATGAGTTCGCCTGTGTTGTGGCAGATGCTGTCATAAAAACTTTGCAACCAGTATCTGAATTACTTACACC
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/ref.fasta.fai Tue Sep 01 03:08:24 2020 -0400 @@ -0,0 +1,1 @@ +NC_045512.2 2940 13 2940 2941
--- a/variant.xml Thu Jun 18 05:08:21 2020 -0400 +++ b/variant.xml Tue Sep 01 03:08:24 2020 -0400 @@ -1,5 +1,5 @@ <?xml version="1.0"?> -<tool id="medaka_variant" name="medaka: Variant" version="@TOOL_VERSION@+galaxy0" profile="@PROFILE@"> +<tool id="medaka_variant" name="medaka: Variant" version="@TOOL_VERSION@+galaxy1" profile="@PROFILE@"> <description>Probability decoding</description> <macros> <import>macros.xml</import> @@ -25,62 +25,80 @@ #end for '$out_result' ## output -|& tee '$out_log' +2>&1 | tee '$out_log' + +#if $out_annotated + && python '$__tool_directory__/annotateVCF.py' '$out_result' '$in_mpileup' '$out_annotated' +#end if ]]></command> <inputs> <param argument="inputs" type="data" format="h5" multiple="true" label="Select consensus file(s)"/> <expand macro="reference"/> - <param argument="--region" type="text" value="" optional="true" label="Set reference names to limit variant calling" help="Separated by ','."/> + <param argument="--region" type="text" value="" optional="true" label="Set reference names to limit variant calling" help="Separated by ','."> + <sanitizer invalid_char=""> + <valid initial="string.ascii_letters,string.digits"> + <add value="_"/> + <add value=","/> + <add value="."/> + </valid> + </sanitizer> + </param> <param argument="--verbose" type="boolean" truevalue="--verbose" falsevalue="" label="Populate VCF info fields?"/> - <param name="out" type="select" multiple="true" optional="false" label="Select output file(s)"> - <option value="result" selected="true">Result</option> - <option value="log">Log</option> - </param> + + <conditional name="output_annotated"> + <param name="output_annotated_select" type="select" label="Output annotated VCF?" help="Annotate allele frequency, depth of coverage, etc for each variant (requires pileup file)"> + <option value="true" selected="true">Output annotated VCF</option> + <option value="false">Don't output annotated VCF</option> + </param> + <when value="true"> + <param name="in_mpileup" type = "data" format="pileup" optional="false" label="Mpileup to annotate the VCF"/> + </when> + </conditional> + <param name="output_log_bool" type="boolean" label="Output log file?" checked="true"/> </inputs> <outputs> <!-- standard --> - <data name="out_result" format="vcf" label="${tool.name} on ${on_string}: Result"> - <filter>'result' in out</filter> + <data name="out_result" format="vcf" label="${tool.name} on ${on_string}: Result"/> + <!-- optional --> + <data name="out_annotated" format="vcf" label="${tool.name} on ${on_string}: Annotated"> + <filter>output_annotated_select</filter> </data> - <!-- optional --> <data name="out_log" format="tabular" label="${tool.name} on ${on_string}: Log"> - <filter>'log' in out</filter> + <filter>output_log_bool</filter> </data> </outputs> <tests> <!-- #1 default --> - <test expect_num_outputs="1"> + <test expect_num_outputs="3"> + <param name="inputs" value="medaka_test.hdf"/> <conditional name="reference_source"> - <param name="reference_source_selector" value="cached"/> - <param name="ref_file" value="bwa-mem-mt-genome"/> + <param name="reference_source_selector" value="history"/> + <param name="ref_file" value="ref.fasta"/> </conditional> - <param name="inputs" value="consensus.hdf"/> + <conditional name="output_annotated"> + <param name="output_annotated_select" value="true"/> + <param name="in_mpileup" value="annotate_vcf_test.pileup"/> + </conditional> + <param name="output_log_bool" value="true"/> + <output name="out_result"> <assert_contents> - <has_n_lines n="6"/> - <has_line line="##fileformat=VCFv4.1"/> + <has_n_lines n="9"/> + <has_line line="##fileformat=VCFv4.1" /> + <has_line line="##medaka_version=1.0.3" /> </assert_contents> </output> - </test> - <!-- #2 --> - <test expect_num_outputs="2"> - <conditional name="reference_source"> - <param name="reference_source_selector" value="cached"/> - <param name="ref_file" value="bwa-mem-mt-genome"/> - </conditional> - <param name="inputs" value="consensus.hdf"/> - <param name="verbose" value="true"/> - <param name="out" value="result,log"/> - <output name="out_result"> + <output name="out_annotated"> <assert_contents> - <has_n_lines n="13"/> - <has_line line="##fileformat=VCFv4.1"/> + <has_n_lines n="16"/> + <has_line line="##fileformat=VCFv4.1" /> + <has_line line="##medaka_version=1.0.3" /> + <has_line line="##annotateVCFVersion=0.1" /> </assert_contents> </output> <output name="out_log"> <assert_contents> - <has_n_lines n="17"/> - <has_text_matching expression=".+Loaded.+"/> + <has_n_lines n="8" /> </assert_contents> </output> </test> @@ -108,4 +126,4 @@ @REFERENCES@ ]]></help> <expand macro="citations"/> -</tool> \ No newline at end of file +</tool>