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diff tools/myTools/bin/sfa/data/flobak_2015/network.sif @ 1:7e5c71b2e71f draft default tip

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author laurenmarazzi
date Wed, 22 Dec 2021 16:00:34 +0000
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--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/tools/myTools/bin/sfa/data/flobak_2015/network.sif	Wed Dec 22 16:00:34 2021 +0000
@@ -0,0 +1,149 @@
+p38alpha	-	TAB1
+AKT	+	CFLAR
+ITCH	-	CFLAR
+AKT	+	IKKA
+DKK1gene	+	DKK1
+AKT	-	pras40
+LRP	-	Axin
+betacatenin	+	TCF
+NLK	-	TCF
+TCF	+	cMYC
+FOXO	+	RTPKgene
+GSK3	+	TSC2
+IKKB	-	TSC2
+AKT	-	TSC2
+RSK	-	TSC2
+ERK	-	TSC2
+cMYC	-	SFRP1gene
+CytochromeC	+	Caspase9
+p38alpha	+	p53
+MDM2	-	p53
+TCF	+	DKK1gene
+cMYC	-	DKK1gene
+GRB2	+	GAB
+ERK	-	GAB
+PDK1	+	AKT
+mTORC2	+	AKT
+AKT	-	ASK1
+ERK	+	RSK
+PDK1	+	RSK
+GAB	+	SHP2
+SOS	+	Ras
+SHP2	+	Ras
+Rac	+	MEKK4
+PDK1	+	S6K
+mTORC1	+	S6K
+ASK1	+	MKK3
+TAK1	+	MKK3
+PI3K	+	PDK1
+PTEN	-	PDK1
+Raf	+	MEK
+MAP3K8	+	MEK
+ERK	-	MEK
+p38alpha	+	DUSP1
+MSK	+	DUSP1
+AKT	-	BAD
+RSK	-	BAD
+p53	+	BAX
+TAB1	+	TAK1
+RTPKgene	+	RTPK
+MMP	+	RTPK
+p38alpha	-	RTPK
+MEK	-	RTPK
+LRP	-	CK1
+TCF	-	Egr1
+GRB2	+	SOS
+ERK	-	SOS
+BAD	-	BCL2
+TAK1	+	MKK7
+GRAP2	+	MKK7
+Fz	+	LRP
+ERK	+	LRP
+JNK1	+	LRP
+p38alpha	+	LRP
+DKK1	-	LRP
+SHC1	+	GRB2
+IKKB	+	MAP3K8
+CFLAR	-	Caspase8
+AKT	-	FOXO
+NLK	-	FOXO
+LRP	-	GSK3
+RSK	-	GSK3
+S6K	-	GSK3
+ERK	-	GSK3
+p38alpha	-	GSK3
+Dvl	-	GSK3
+AKT	-	GSK3
+Ras	+	Raf
+Rheb	-	Raf
+AKT	-	Raf
+ERK	-	Raf
+JNK1	+	ITCH
+Rac	+	MLK3
+Egr1	+	PTENgene
+MKK3	+	p38alpha
+MKK4	+	p38alpha
+DUSP1	-	p38alpha
+TAK1	+	IKKB
+p53	-	IKKB
+ERK	+	MSK
+p38alpha	+	MSK
+AKT	+	MDM2
+MDM2gene	+	MDM2
+S6K	-	MDM2
+NFkB	+	MDM2gene
+p53	+	MDM2gene
+ERK	+	DUSP6
+mTORC1	+	DUSP6
+IKKA	+	NFkB
+IKKB	+	NFkB
+MSK	+	NFkB
+MKK7	+	JNK1
+MKK4	+	JNK1
+DUSP1	-	JNK1
+MEK	+	ERK
+DUSP6	-	ERK
+TSC2	-	Rheb
+Dvl	+	Rac
+mTORC2	+	Rac
+BAX	+	CytochromeC
+BCL2	-	CytochromeC
+IKKA	+	betacatenin
+betaTrCP	-	betacatenin
+MEKK4	+	MKK4
+MLK3	+	MKK4
+TAK1	+	MKK4
+GRAP2	+	MKK4
+TSC2	+	mTORC2
+S6K	-	mTORC2
+RTPK	+	SHC1
+PTEN	-	SHC1
+S6K	-	IRS1
+ERK	-	IRS1
+IKKB	-	IRS1
+Rheb	+	mTORC1
+RSK	+	mTORC1
+pras40	-	mTORC1
+TAK1	+	NLK
+Fz	+	Dvl
+Axin	+	betaTrCP
+GSK3	+	betaTrCP
+CK1	+	betaTrCP
+SFRP1gene	+	SFRP1
+SFRP1	-	Fz
+LEF	+	MMP
+GAB	+	PI3K
+IRS1	+	PI3K
+Ras	+	PI3K
+betacatenin	+	LEF
+PTENgene	+	PTEN
+GSK3	-	PTEN
+p38alpha	-	GRAP2
+RSK	+	CCND1
+TCF	+	CCND1
+Caspase8	+	Caspase37
+Caspase9	+	Caspase37
+Caspase37	+	Antisurvival
+FOXO	+	Antisurvival
+CCND1	+	Prosurvival
+cMYC	+	Prosurvival
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