Mercurial > repos > proteore > proteore_build_protein_interaction_maps
annotate test-data/Nodes_biogrid_from_Lacombe_geneID.tsv @ 5:ba96ca3496a2 draft default tip
"planemo upload commit c9a32e920aae2bc186183611bc0abb2040e106f3"
author | proteore |
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date | Thu, 06 Feb 2020 08:28:04 -0500 |
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1 Entrez gene ID Official Symbol Interactor Present in user input ids ID present in Biogrid Human Pathway |
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2 2 A2M False True Platelet degranulation ;Intrinsic Pathway of Fibrin Clot Formation;Degradation of the extracellular matrix;Rho GTPase cycle;HDL assembly |
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3 12 SERPINA3 True True Platelet degranulation ;Neutrophil degranulation |
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4 15 AANAT False True Serotonin and melatonin biosynthesis |
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5 16 AARS False True Cytosolic tRNA aminoacylation |
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6 18 ABAT False True Degradation of GABA |
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7 25 ABL1 False True Regulation of actin dynamics for phagocytic cup formation;CDO in myogenesis;CDO in myogenesis;Role of ABL in ROBO-SLIT signaling;Role of ABL in ROBO-SLIT signaling;RHO GTPases Activate WASPs and WAVEs;HDR through Single Strand Annealing (SSA);Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Cyclin D associated events in G1;RUNX1 regulates transcription of genes involved in differentiation of HSCs;RUNX2 regulates osteoblast differentiation;Factors involved in megakaryocyte development and platelet production |
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8 27 ABL2 False True Role of ABL in ROBO-SLIT signaling;Role of ABL in ROBO-SLIT signaling |
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9 30 ACAA1 False True alpha-linolenic acid (ALA) metabolism;Beta-oxidation of very long chain fatty acids;Neutrophil degranulation;Peroxisomal protein import;Peroxisomal protein import;TYSND1 cleaves peroxisomal proteins |
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10 31 ACACA False True ChREBP activates metabolic gene expression;Biotin transport and metabolism;Import of palmitoyl-CoA into the mitochondrial matrix;Activation of gene expression by SREBF (SREBP);Defective HLCS causes multiple carboxylase deficiency;Fatty acyl-CoA biosynthesis |
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11 34 ACADM False True PPARA activates gene expression;mitochondrial fatty acid beta-oxidation of unsaturated fatty acids;Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA;Beta oxidation of octanoyl-CoA to hexanoyl-CoA |
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12 38 ACAT1 False True Branched-chain amino acid catabolism;Utilization of Ketone Bodies;Synthesis of Ketone Bodies |
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13 39 ACAT2 False True Cholesterol biosynthesis |
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14 48 ACO1 False True Iron uptake and transport |
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15 50 ACO2 False True Mitochondrial protein import;Citric acid cycle (TCA cycle) |
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16 58 ACTA1 False True Striated Muscle Contraction |
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17 59 ACTA2 False True Smooth Muscle Contraction;NOTCH4 Intracellular Domain Regulates Transcription |
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18 60 ACTB False True Translocation of SLC2A4 (GLUT4) to the plasma membrane;Gap junction degradation;Formation of annular gap junctions;Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;HATs acetylate histones;Prefoldin mediated transfer of substrate to CCT/TriC;Folding of actin by CCT/TriC;EPHB-mediated forward signaling;EPH-ephrin mediated repulsion of cells;Adherens junctions interactions;Adherens junctions interactions;Recycling pathway of L1;Recycling pathway of L1;VEGFA-VEGFR2 Pathway;Interaction between L1 and Ankyrins;Interaction between L1 and Ankyrins;Cell-extracellular matrix interactions;B-WICH complex positively regulates rRNA expression;RHO GTPases activate IQGAPs;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate Formins;RHO GTPases Activate Formins;MAP2K and MAPK activation;UCH proteinases;DNA Damage Recognition in GG-NER;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF;Clathrin-mediated endocytosis;Factors involved in megakaryocyte development and platelet production |
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19 70 ACTC1 False True Striated Muscle Contraction |
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20 71 ACTG1 True True Translocation of SLC2A4 (GLUT4) to the plasma membrane;Gap junction degradation;Formation of annular gap junctions;Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;EPHB-mediated forward signaling;EPH-ephrin mediated repulsion of cells;Adherens junctions interactions;Adherens junctions interactions;Recycling pathway of L1;Recycling pathway of L1;VEGFA-VEGFR2 Pathway;Interaction between L1 and Ankyrins;Interaction between L1 and Ankyrins;Cell-extracellular matrix interactions;RHO GTPases activate IQGAPs;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate Formins;RHO GTPases Activate Formins;MAP2K and MAPK activation;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF;Clathrin-mediated endocytosis |
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21 81 ACTN4 True True Platelet degranulation ;Nephrin family interactions |
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22 87 ACTN1 False True Platelet degranulation ;Syndecan interactions;Nephrin family interactions;Regulation of cytoskeletal remodeling and cell spreading by IPP complex components |
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23 88 ACTN2 False True Platelet degranulation ;Nephrin family interactions;Striated Muscle Contraction;Unblocking of NMDA receptors, glutamate binding and activation;Unblocking of NMDA receptors, glutamate binding and activation;Ras activation upon Ca2+ influx through NMDA receptor;RAF/MAP kinase cascade;Negative regulation of NMDA receptor-mediated neuronal transmission;Long-term potentiation |
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24 89 ACTN3 False True Nephrin family interactions;Striated Muscle Contraction |
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25 91 ACVR1B False True Signaling by NODAL;Regulation of signaling by NODAL;Signaling by Activin |
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26 93 ACVR2B False True Signaling by NODAL;Regulation of signaling by NODAL;Signaling by Activin;Signaling by Activin;Signaling by BMP |
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27 95 ACY1 False True Aflatoxin activation and detoxification;Defective ACY1 causes encephalopathy |
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28 115 NA False True Glucagon signaling in metabolic regulation;PKA activation;PKA activation in glucagon signalling;Adenylate cyclase activating pathway;Adenylate cyclase inhibitory pathway;Adenylate cyclase inhibitory pathway;G alpha (s) signalling events;G alpha (s) signalling events;G alpha (i) signalling events;G alpha (z) signalling events;G alpha (z) signalling events;Vasopressin regulates renal water homeostasis via Aquaporins;Hedgehog 'off' state |
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29 119 ADD2 False True Miscellaneous transport and binding events |
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30 120 NA False True Miscellaneous transport and binding events |
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31 125 ADH1B False True Ethanol oxidation |
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32 127 ADH4 False True RA biosynthesis pathway;Ethanol oxidation |
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33 132 ADK False True Purine salvage |
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34 140 ADORA3 False True Adenosine P1 receptors;G alpha (i) signalling events |
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35 142 PARP1 False True POLB-Dependent Long Patch Base Excision Repair;Downregulation of SMAD2/3:SMAD4 transcriptional activity;SUMOylation of DNA damage response and repair proteins;HDR through MMEJ (alt-NHEJ);DNA Damage Recognition in GG-NER;Formation of Incision Complex in GG-NER;Dual Incision in GG-NER |
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36 147 ADRA1B False True Adrenoceptors;G alpha (q) signalling events;G alpha (12/13) signalling events |
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37 157 ADRBK2 False True G alpha (s) signalling events;Cargo recognition for clathrin-mediated endocytosis |
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38 158 ADSL False True Purine ribonucleoside monophosphate biosynthesis |
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39 159 ADSS False True Purine ribonucleoside monophosphate biosynthesis |
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40 160 AP2A1 False True Nef Mediated CD4 Down-regulation;Retrograde neurotrophin signalling;Retrograde neurotrophin signalling;Nef Mediated CD8 Down-regulation;MHC class II antigen presentation;EPH-ephrin mediated repulsion of cells;Trafficking of GluR2-containing AMPA receptors;Recycling pathway of L1;Recycling pathway of L1;WNT5A-dependent internalization of FZD4;WNT5A-dependent internalization of FZD2, FZD5 and ROR2;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;VLDLR internalisation and degradation;LDL clearance |
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41 163 AP2B1 False True Nef Mediated CD4 Down-regulation;Retrograde neurotrophin signalling;Retrograde neurotrophin signalling;Nef Mediated CD8 Down-regulation;MHC class II antigen presentation;EPH-ephrin mediated repulsion of cells;Trafficking of GluR2-containing AMPA receptors;Recycling pathway of L1;Recycling pathway of L1;WNT5A-dependent internalization of FZD4;WNT5A-dependent internalization of FZD2, FZD5 and ROR2;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;VLDLR internalisation and degradation;LDL clearance |
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42 164 AP1G1 False True Nef mediated downregulation of MHC class I complex cell surface expression;MHC class II antigen presentation;Lysosome Vesicle Biogenesis;Golgi Associated Vesicle Biogenesis |
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43 166 AES False True Repression of WNT target genes |
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44 175 AGA True True Neutrophil degranulation |
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45 178 AGL False True Neutrophil degranulation;Glycogen breakdown (glycogenolysis) |
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46 189 NA False True Glyoxylate metabolism and glycine degradation;Peroxisomal protein import;Peroxisomal protein import |
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47 191 AHCY False True Methylation;Sulfur amino acid metabolism;Metabolism of ingested SeMet, Sec, MeSec into H2Se;Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) |
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48 196 AHR False True PPARA activates gene expression;Phase I - Functionalization of compounds;Endogenous sterols;Xenobiotics;Aryl hydrocarbon receptor signalling |
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49 197 AHSG False True Platelet degranulation ;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Neutrophil degranulation;Post-translational protein phosphorylation |
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50 204 AK2 False True Interconversion of nucleotide di- and triphosphates |
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51 207 AKT1 False True Activation of BAD and translocation to mitochondria ;PIP3 activates AKT signaling;PIP3 activates AKT signaling;Downregulation of ERBB2:ERBB3 signaling;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation;mTOR signalling;AKT phosphorylates targets in the cytosol;AKT phosphorylates targets in the cytosol;AKT phosphorylates targets in the nucleus;Negative regulation of the PI3K/AKT network;eNOS activation;AKT-mediated inactivation of FOXO1A;Integrin alphaIIb beta3 signaling;Deactivation of the beta-catenin transactivating complex;CD28 dependent PI3K/Akt signaling;CTLA4 inhibitory signaling;G beta:gamma signalling through PI3Kgamma;Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA;KSRP (KHSRP) binds and destabilizes mRNA;VEGFR2 mediated vascular permeability;TP53 Regulates Metabolic Genes;Constitutive Signaling by AKT1 E17K in Cancer;Interleukin-4 and Interleukin-13 signaling;Regulation of TP53 Degradation;Regulation of TP53 Activity through Acetylation;Regulation of TP53 Activity through Association with Co-factors;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Cyclin E associated events during G1/S transition ;Cyclin A:Cdk2-associated events at S phase entry;PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1;RAB GEFs exchange GTP for GDP on RABs;RUNX2 regulates genes involved in cell migration;Regulation of PTEN stability and activity;Negative regulation of NOTCH4 signaling;Regulation of localization of FOXO transcription factors |
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52 208 AKT2 False True Activation of BAD and translocation to mitochondria ;PIP3 activates AKT signaling;PIP3 activates AKT signaling;Downregulation of ERBB2:ERBB3 signaling;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Activation of AKT2;PDE3B signalling;Inhibition of TSC complex formation by PKB;AKT phosphorylates targets in the cytosol;AKT phosphorylates targets in the cytosol;AKT phosphorylates targets in the nucleus;Negative regulation of the PI3K/AKT network;AKT-mediated inactivation of FOXO1A;Deactivation of the beta-catenin transactivating complex;CD28 dependent PI3K/Akt signaling;CTLA4 inhibitory signaling;G beta:gamma signalling through PI3Kgamma;VEGFR2 mediated vascular permeability;TP53 Regulates Metabolic Genes;Constitutive Signaling by AKT1 E17K in Cancer;Regulation of TP53 Degradation;Regulation of TP53 Activity through Acetylation;Regulation of TP53 Activity through Association with Co-factors;Cyclin E associated events during G1/S transition ;Cyclin A:Cdk2-associated events at S phase entry;RAB GEFs exchange GTP for GDP on RABs;RUNX2 regulates genes involved in cell migration;Regulation of PTEN stability and activity;Regulation of localization of FOXO transcription factors |
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53 210 ALAD False True Heme biosynthesis;Neutrophil degranulation |
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54 213 ALB True True Platelet degranulation ;Recycling of bile acids and salts;Scavenging of heme from plasma;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR);Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR);Transport of organic anions;Post-translational protein phosphorylation;HDL remodeling |
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55 214 ALCAM False True L1CAM interactions |
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56 217 ALDH2 False True Metabolism of serotonin;Ethanol oxidation |
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57 219 ALDH1B1 False True Ethanol oxidation |
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58 224 ALDH3A2 False True Sphingolipid de novo biosynthesis;Alpha-oxidation of phytanate |
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59 226 ALDOA True True Platelet degranulation ;Neutrophil degranulation;Glycolysis;Gluconeogenesis |
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60 229 ALDOB False True Hereditary fructose intolerance;Glycolysis;Gluconeogenesis;Fructose catabolism |
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61 230 ALDOC True True Neutrophil degranulation;Glycolysis;Gluconeogenesis |
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62 231 AKR1B1 False True Pregnenolone biosynthesis;Fructose biosynthesis |
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63 238 ALK False True NA |
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64 242 NA True False Synthesis of 12-eicosatetraenoic acid derivatives |
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65 248 ALPI False True Synthesis of PA;Post-translational modification: synthesis of GPI-anchored proteins;Digestion |
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66 262 AMD1 False True Metabolism of polyamines |
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67 267 AMFR False True N-glycan trimming in the ER and Calnexin/Calreticulin cycle;ER Quality Control Compartment (ERQC) |
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68 269 AMHR2 False True Signaling by BMP |
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69 272 NA False True Neutrophil degranulation;Purine salvage |
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70 274 BIN1 False True Clathrin-mediated endocytosis |
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71 275 NA False True Glycine degradation |
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72 276 AMY1A True True Digestion of dietary carbohydrate |
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73 277 NA True False Digestion of dietary carbohydrate |
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74 278 NA True False Digestion of dietary carbohydrate |
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75 286 ANK1 False True Interaction between L1 and Ankyrins;Interaction between L1 and Ankyrins;NrCAM interactions;CHL1 interactions;Neurofascin interactions;Neurofascin interactions;COPI-mediated anterograde transport |
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76 292 SLC25A5 False True Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization;Regulation of insulin secretion |
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77 293 SLC25A6 False True Mitochondrial protein import;Mitochondrial protein import;Influenza Virus Induced Apoptosis;Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization;Regulation of insulin secretion |
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78 301 ANXA1 True True G alpha (q) signalling events;G alpha (i) signalling events;Formyl peptide receptors bind formyl peptides and many other ligands;Smooth Muscle Contraction;Interleukin-4 and Interleukin-13 signaling |
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79 302 ANXA2 True True Smooth Muscle Contraction;Neutrophil degranulation;Dissolution of Fibrin Clot;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation |
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80 307 ANXA4 False True NA |
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81 308 ANXA5 False True Platelet degranulation |
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82 309 ANXA6 False True Smooth Muscle Contraction |
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83 310 ANXA7 False True NA |
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84 312 ANXA13 False True NA |
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85 317 APAF1 False True Formation of apoptosome;Activation of caspases through apoptosome-mediated cleavage;SMAC (DIABLO) binds to IAPs ;SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ;Neutrophil degranulation;TP53 Regulates Transcription of Caspase Activators and Caspases;Transcriptional Regulation by E2F6;Regulation of the apoptosome activity;Regulation of the apoptosome activity |
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86 322 APBB1 False True Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks |
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87 324 APC False True Apoptotic cleavage of cellular proteins;Degradation of beta-catenin by the destruction complex;Beta-catenin phosphorylation cascade;Deactivation of the beta-catenin transactivating complex;Disassembly of the destruction complex and recruitment of AXIN to the membrane;Disassembly of the destruction complex and recruitment of AXIN to the membrane;Misspliced GSK3beta mutants stabilize beta-catenin;S33 mutants of beta-catenin aren't phosphorylated;S37 mutants of beta-catenin aren't phosphorylated;S45 mutants of beta-catenin aren't phosphorylated;T41 mutants of beta-catenin aren't phosphorylated;APC truncation mutants are not K63 polyubiquitinated;APC truncation mutants have impaired AXIN binding;AXIN missense mutants destabilize the destruction complex;Truncations of AMER1 destabilize the destruction complex;Ovarian tumor domain proteases |
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88 328 APEX1 False True Displacement of DNA glycosylase by APEX1;POLB-Dependent Long Patch Base Excision Repair;Resolution of AP sites via the multiple-nucleotide patch replacement pathway;PCNA-Dependent Long Patch Base Excision Repair;Abasic sugar-phosphate removal via the single-nucleotide replacement pathway;Resolution of Abasic Sites (AP sites) |
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89 332 BIRC5 False True Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;SUMOylation of DNA replication proteins;RHO GTPases Activate Formins;Interleukin-4 and Interleukin-13 signaling;TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain;Mitotic Prometaphase;Neddylation |
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90 333 APLP1 False True NA |
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91 334 APLP2 False True Platelet degranulation ;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation |
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92 335 APOA1 False True Platelet degranulation ;ABC transporters in lipid homeostasis;PPARA activates gene expression;Scavenging of heme from plasma;Scavenging by Class B Receptors;Scavenging by Class B Receptors;Scavenging by Class A Receptors;Scavenging by Class A Receptors;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation;Chylomicron assembly;HDL assembly;Chylomicron remodeling;HDL clearance;HDL remodeling;Retinoid metabolism and transport;Retinoid metabolism and transport;Amyloid fiber formation |
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93 336 APOA2 False True PPARA activates gene expression;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation;Chylomicron assembly;Chylomicron remodeling;Retinoid metabolism and transport;Retinoid metabolism and transport |
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94 337 NA False True NA |
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95 338 APOB False True Cell surface interactions at the vascular wall;Scavenging by Class B Receptors;Scavenging by Class B Receptors;Scavenging by Class A Receptors;Scavenging by Class A Receptors;Scavenging by Class F Receptors;Scavenging by Class F Receptors;Scavenging by Class H Receptors;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Platelet sensitization by LDL;Regulation of TLR by endogenous ligand;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;VLDL assembly;Post-translational protein phosphorylation;Chylomicron assembly;Chylomicron remodeling;Chylomicron clearance;Chylomicron clearance;LDL clearance;LDL clearance;LDL remodeling;VLDL clearance;VLDL clearance;Retinoid metabolism and transport;Retinoid metabolism and transport |
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96 341 APOC1 False True VLDL assembly;VLDL clearance;VLDL clearance |
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97 344 APOC2 False True Chylomicron assembly;Assembly of active LPL and LIPC lipase complexes;Chylomicron remodeling;HDL remodeling;Retinoid metabolism and transport;Retinoid metabolism and transport |
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98 345 APOC3 False True Chylomicron assembly;Chylomicron remodeling;HDL remodeling;Retinoid metabolism and transport;Retinoid metabolism and transport |
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99 347 APOD True True Transport of fatty acids |
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100 348 APOE False True Scavenging by Class A Receptors;Scavenging by Class A Receptors;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors;Post-translational protein phosphorylation;Chylomicron assembly;Chylomicron remodeling;Chylomicron clearance;Chylomicron clearance;HDL remodeling;Retinoid metabolism and transport;Retinoid metabolism and transport |
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101 350 APOH False True Platelet degranulation |
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102 351 APP False True Platelet degranulation ;ECM proteoglycans;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);G alpha (q) signalling events;G alpha (i) signalling events;Lysosome Vesicle Biogenesis;Formyl peptide receptors bind formyl peptides and many other ligands;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;The NLRP3 inflammasome;Advanced glycosylation endproduct receptor signaling;Advanced glycosylation endproduct receptor signaling;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Post-translational protein phosphorylation;TRAF6 mediated NF-kB activation;Amyloid fiber formation |
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103 353 APRT False True Neutrophil degranulation;Purine salvage |
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104 354 KLK3 False True Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
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105 357 NA False True NA |
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106 358 AQP1 False True Erythrocytes take up carbon dioxide and release oxygen;Erythrocytes take up oxygen and release carbon dioxide;Vasopressin regulates renal water homeostasis via Aquaporins;Passive transport by Aquaporins |
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107 360 AQP3 False True Vasopressin regulates renal water homeostasis via Aquaporins;Passive transport by Aquaporins |
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108 367 AR False True HSP90 chaperone cycle for steroid hormone receptors (SHR);Nuclear Receptor transcription pathway;SUMOylation of intracellular receptors;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Ub-specific processing proteases;RUNX2 regulates osteoblast differentiation;RUNX2 regulates osteoblast differentiation |
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109 369 ARAF False True RAF activation;MAP2K and MAPK activation;Negative regulation of MAPK pathway;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF |
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110 372 ARCN1 False True COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic |
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111 373 TRIM23 False True NA |
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112 378 ARF4 False True VxPx cargo-targeting to cilium;VxPx cargo-targeting to cilium;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic |
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113 381 ARF5 False True COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic |
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114 383 ARG1 True True Neutrophil degranulation;Urea cycle |
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115 384 ARG2 False True Urea cycle |
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116 387 RHOA False True GPVI-mediated activation cascade;Axonal growth inhibition (RHOA activation);Rho GTPase cycle;PI3K/AKT activation;Axonal growth stimulation;TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);G beta:gamma signalling through PI3Kgamma;EPHB-mediated forward signaling;EPHB-mediated forward signaling;EPHA-mediated growth cone collapse;EPHA-mediated growth cone collapse;PCP/CE pathway;G alpha (12/13) signalling events;Sema4D mediated inhibition of cell attachment and migration;Sema4D induced cell migration and growth-cone collapse;Sema4D induced cell migration and growth-cone collapse;VEGFA-VEGFR2 Pathway;RHO GTPases activate PKNs;RHO GTPases activate CIT;RHO GTPases activate CIT;RHO GTPases activate KTN1;RHO GTPases Activate ROCKs;RHO GTPases Activate ROCKs;RHO GTPases Activate Formins;RHO GTPases Activate Rhotekin and Rhophilins;RHO GTPases Activate Rhotekin and Rhophilins;Ovarian tumor domain proteases;ERBB2 Regulates Cell Motility;Neutrophil degranulation;PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases;SLIT2:ROBO1 increases RHOA activity |
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117 390 RND3 False True NA |
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118 396 ARHGDIA False True Axonal growth inhibition (RHOA activation);Rho GTPase cycle;Axonal growth stimulation |
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119 398 ARHGDIG False True Rho GTPase cycle |
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120 405 ARNT False True Regulation of gene expression by Hypoxia-inducible Factor;PPARA activates gene expression;Phase I - Functionalization of compounds;Endogenous sterols;Xenobiotics;Aryl hydrocarbon receptor signalling |
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121 406 ARNTL False True BMAL1:CLOCK,NPAS2 activates circadian gene expression;BMAL1:CLOCK,NPAS2 activates circadian gene expression;PPARA activates gene expression;Circadian Clock |
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122 427 ASAH1 False True Glycosphingolipid metabolism;Neutrophil degranulation |
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123 432 ASGR1 False True Asparagine N-linked glycosylation |
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124 439 ASNA1 False True XBP1(S) activates chaperone genes |
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125 440 ASNS False True ATF4 activates genes;Amino acid synthesis and interconversion (transamination) |
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126 444 ASPH False True Stimuli-sensing channels;Ion homeostasis |
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127 445 ASS1 False True Urea cycle |
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128 466 ATF1 False True CREB phosphorylation |
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129 467 ATF3 False True ATF4 activates genes |
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130 471 ATIC False True Purine ribonucleoside monophosphate biosynthesis |
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131 472 ATM False True DNA Damage/Telomere Stress Induced Senescence;Regulation of HSF1-mediated heat shock response;Autodegradation of the E3 ubiquitin ligase COP1;HDR through Single Strand Annealing (SSA);HDR through Homologous Recombination (HRR);Sensing of DNA Double Strand Breaks;Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA);Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Resolution of D-loop Structures through Holliday Junction Intermediates;Nonhomologous End-Joining (NHEJ);Homologous DNA Pairing and Strand Exchange;Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;TP53 Regulates Transcription of DNA Repair Genes;TP53 Regulates Transcription of Genes Involved in Cytochrome C Release;TP53 Regulates Transcription of Caspase Activators and Caspases;Regulation of TP53 Activity through Phosphorylation;Regulation of TP53 Degradation;Regulation of TP53 Activity through Methylation;G2/M DNA damage checkpoint;Stabilization of p53;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Meiotic recombination |
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132 475 ATOX1 False True Detoxification of Reactive Oxygen Species;Ion influx/efflux at host-pathogen interface |
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133 476 ATP1A1 False True Ion homeostasis;Ion transport by P-type ATPases |
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134 488 ATP2A2 False True Pre-NOTCH Processing in Golgi;Reduction of cytosolic Ca++ levels;Ion homeostasis;Ion transport by P-type ATPases |
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135 491 ATP2B2 False True Reduction of cytosolic Ca++ levels;Ion homeostasis;Ion transport by P-type ATPases |
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136 493 ATP2B4 False True Reduction of cytosolic Ca++ levels;Ion homeostasis;Ion transport by P-type ATPases |
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137 498 ATP5A1 True True Mitochondrial protein import;Formation of ATP by chemiosmotic coupling;Cristae formation |
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138 501 ALDH7A1 False True Choline catabolism;Lysine catabolism |
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139 506 ATP5B False True Mitochondrial protein import;Mitochondrial protein import;Formation of ATP by chemiosmotic coupling;Transcriptional activation of mitochondrial biogenesis;Cristae formation |
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140 509 ATP5C1 False True Formation of ATP by chemiosmotic coupling;Cristae formation |
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141 513 ATP5D False True Formation of ATP by chemiosmotic coupling;Cristae formation |
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142 514 ATP5E False True Formation of ATP by chemiosmotic coupling;Cristae formation |
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143 515 ATP5F1 False True Formation of ATP by chemiosmotic coupling;Cristae formation |
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144 521 ATP5I False True Formation of ATP by chemiosmotic coupling;Cristae formation |
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145 522 ATP5J False True Formation of ATP by chemiosmotic coupling;Cristae formation |
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146 523 ATP6V1A False True ROS, RNS production in phagocytes;Insulin receptor recycling;Transferrin endocytosis and recycling;Ion channel transport |
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147 525 ATP6V1B1 False True ROS, RNS production in phagocytes;Insulin receptor recycling;Transferrin endocytosis and recycling;Ion channel transport |
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148 526 ATP6V1B2 False True ROS, RNS production in phagocytes;Insulin receptor recycling;Transferrin endocytosis and recycling;Ion channel transport |
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149 527 ATP6V0C False True ROS, RNS production in phagocytes;Neutrophil degranulation;Insulin receptor recycling;Transferrin endocytosis and recycling;Ion channel transport |
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150 533 ATP6V0B False True ROS, RNS production in phagocytes;Insulin receptor recycling;Transferrin endocytosis and recycling;Ion channel transport |
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151 539 ATP5O False True Formation of ATP by chemiosmotic coupling;Cristae formation |
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152 545 ATR False True Meiotic synapsis;Activation of ATR in response to replication stress;Regulation of HSF1-mediated heat shock response;HDR through Single Strand Annealing (SSA);Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;Fanconi Anemia Pathway;TP53 Regulates Transcription of DNA Repair Genes;Regulation of TP53 Activity through Phosphorylation;G2/M DNA damage checkpoint |
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153 558 AXL False True VEGFA-VEGFR2 Pathway |
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154 563 AZGP1 True True Miscellaneous transport and binding events |
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155 572 BAD False True Activation of BAD and translocation to mitochondria ;Activation of BAD and translocation to mitochondria ;BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members;NRAGE signals death through JNK;AKT phosphorylates targets in the cytosol;Constitutive Signaling by AKT1 E17K in Cancer |
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156 573 BAG1 False True Regulation of HSF1-mediated heat shock response |
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157 581 BAX False True Release of apoptotic factors from the mitochondria;Activation, translocation and oligomerization of BAX;TP53 Regulates Transcription of Genes Involved in Cytochrome C Release;TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest;Transcriptional regulation by RUNX2;NTRK3 as a dependence receptor |
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158 587 BCAT2 False True Branched-chain amino acid catabolism |
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159 593 BCKDHA False True Glyoxylate metabolism and glycine degradation;Branched-chain amino acid catabolism |
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160 595 CCND1 False True SCF(Skp2)-mediated degradation of p27/p21;Pre-NOTCH Transcription and Translation;RMTs methylate histone arginines;Interleukin-4 and Interleukin-13 signaling;Ubiquitin-dependent degradation of Cyclin D1;Ubiquitin-dependent degradation of Cyclin D1;Cyclin D associated events in G1;PTK6 Regulates Cell Cycle;Transcriptional regulation by RUNX2;Regulation of RUNX1 Expression and Activity;RUNX3 regulates WNT signaling;RUNX3 regulates p14-ARF;Estrogen-dependent gene expression |
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161 596 BCL2 False True Activation of BAD and translocation to mitochondria ;BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members;Interleukin-4 and Interleukin-13 signaling;The NLRP1 inflammasome;Estrogen-dependent gene expression |
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162 599 BCL2L2 False True NA |
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163 604 BCL6 False True Interleukin-4 and Interleukin-13 signaling;TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain;FOXO-mediated transcription of cell death genes |
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164 613 BCR False True Signaling by cytosolic FGFR1 fusion mutants;Rho GTPase cycle;Signaling by FGFR1 in disease |
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165 622 BDH1 False True Utilization of Ketone Bodies;Synthesis of Ketone Bodies |
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166 629 CFB False True Alternative complement activation;Activation of C3 and C5;Regulation of Complement cascade |
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167 639 PRDM1 False True Regulation of TP53 Expression |
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168 640 BLK False True RUNX1 regulates transcription of genes involved in BCR signaling;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
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169 641 BLM False True SUMOylation of DNA damage response and repair proteins;HDR through Single Strand Annealing (SSA);HDR through Homologous Recombination (HRR);Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA);Resolution of D-loop Structures through Holliday Junction Intermediates;Homologous DNA Pairing and Strand Exchange;Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;Regulation of TP53 Activity through Phosphorylation;G2/M DNA damage checkpoint;Meiotic recombination |
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170 642 BLMH True True Antigen processing: Ubiquitination & Proteasome degradation |
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171 655 BMP7 False True Molecules associated with elastic fibres |
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172 657 BMPR1A False True Signaling by BMP |
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173 660 BMX False True Apoptotic cleavage of cellular proteins;Synthesis of PIPs at the plasma membrane |
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174 663 BNIP2 False True CDO in myogenesis;CDO in myogenesis |
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175 664 BNIP3 False True NA |
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176 665 BNIP3L False True TP53 Regulates Transcription of Genes Involved in Cytochrome C Release |
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177 667 DST False True Assembly of collagen fibrils and other multimeric structures;Type I hemidesmosome assembly |
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178 672 BRCA1 False True Meiotic synapsis;SUMOylation of DNA damage response and repair proteins;HDR through Single Strand Annealing (SSA);HDR through Homologous Recombination (HRR);Metalloprotease DUBs;Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA);Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Resolution of D-loop Structures through Holliday Junction Intermediates;Nonhomologous End-Joining (NHEJ);Homologous DNA Pairing and Strand Exchange;Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;TP53 Regulates Transcription of DNA Repair Genes;Regulation of TP53 Activity through Phosphorylation;G2/M DNA damage checkpoint;Transcriptional Regulation by E2F6;Meiotic recombination |
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179 673 BRAF False True Spry regulation of FGF signaling;Frs2-mediated activation;ARMS-mediated activation;Signalling to p38 via RIT and RIN;RAF activation;MAP2K and MAPK activation;Negative feedback regulation of MAPK pathway;Negative regulation of MAPK pathway;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF |
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180 678 ZFP36L2 False True NA |
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181 695 BTK False True ER-Phagosome pathway;MyD88:MAL(TIRAP) cascade initiated on plasma membrane;Regulation of actin dynamics for phagocytic cup formation;DAP12 signaling;FCERI mediated Ca+2 mobilization;FCERI mediated Ca+2 mobilization;G alpha (q) signalling events;G alpha (12/13) signalling events;MyD88 deficiency (TLR2/4);IRAK4 deficiency (TLR2/4);RHO GTPases Activate WASPs and WAVEs;G beta:gamma signalling through BTK;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
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182 705 BYSL False True Major pathway of rRNA processing in the nucleolus and cytosol |
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183 706 TSPO False True Pregnenolone biosynthesis |
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184 708 C1QBP False True Intrinsic Pathway of Fibrin Clot Formation |
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185 710 SERPING1 False True Platelet degranulation ;Intrinsic Pathway of Fibrin Clot Formation;Regulation of Complement cascade |
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186 720 C4A False True Initial triggering of complement;Activation of C3 and C5;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation;Regulation of Complement cascade |
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187 727 C5 False True Terminal pathway of complement;Activation of C3 and C5;Peptide ligand-binding receptors;G alpha (i) signalling events;Regulation of Complement cascade |
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188 763 CA5A False True Reversible hydration of carbon dioxide |
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189 780 DDR1 False True Non-integrin membrane-ECM interactions |
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190 786 CACNG1 False True Phase 0 - rapid depolarisation;Phase 2 - plateau phase |
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191 790 CAD False True Pyrimidine biosynthesis |
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192 800 CALD1 False True Smooth Muscle Contraction |
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193 801 CALM1 False True CaMK IV-mediated phosphorylation of CREB;CaMK IV-mediated phosphorylation of CREB;Calmodulin induced events;Cam-PDE 1 activation;CaM pathway;Platelet degranulation ;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation;PKA activation;DARPP-32 events;Synthesis of IP3 and IP4 in the cytosol;Calcineurin activates NFAT;Calcineurin activates NFAT;eNOS activation;Transcriptional activation of mitochondrial biogenesis;Inactivation, recovery and regulation of the phototransduction cascade;Inactivation, recovery and regulation of the phototransduction cascade;Stimuli-sensing channels;FCERI mediated Ca+2 mobilization;FCERI mediated Ca+2 mobilization;Ca2+ pathway;Reduction of cytosolic Ca++ levels;Sodium/Calcium exchangers;Unblocking of NMDA receptors, glutamate binding and activation;CREB1 phosphorylation through the activation of Adenylate Cyclase;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;Ras activation upon Ca2+ influx through NMDA receptor;Smooth Muscle Contraction;Smooth Muscle Contraction;Activation of Ca-permeable Kainate Receptor;Uptake and function of anthrax toxins;VEGFR2 mediated vascular permeability;VEGFR2 mediated cell proliferation;Phase 0 - rapid depolarisation;Ion homeostasis;CLEC7A (Dectin-1) induces NFAT activation;CLEC7A (Dectin-1) induces NFAT activation;RHO GTPases activate IQGAPs;RHO GTPases activate PAKs;RHO GTPases activate PAKs;RAF activation;RAF/MAP kinase cascade;Signaling by moderate kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF;Glycogen breakdown (glycogenolysis);Glycogen breakdown (glycogenolysis);Protein methylation;Loss of phosphorylation of MECP2 at T308;Regulation of MECP2 expression and activity;Ion transport by P-type ATPases;Negative regulation of NMDA receptor-mediated neuronal transmission;Activation of RAC1 downstream of NMDARs;Activation of RAC1 downstream of NMDARs;Activation of AMPK downstream of NMDARs;Long-term potentiation;Long-term potentiation;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
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194 810 CALML3 True True NA |
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195 811 CALR False True ER-Phagosome pathway;Assembly of Viral Components at the Budding Site;Scavenging by Class A Receptors;Scavenging by Class A Receptors;Scavenging by Class F Receptors;Scavenging by Class F Receptors;ATF6 (ATF6-alpha) activates chaperone genes;Calnexin/calreticulin cycle;Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
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196 813 CALU False True Platelet degranulation ;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation |
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197 814 CAMK4 False True CaMK IV-mediated phosphorylation of CREB;CaMK IV-mediated phosphorylation of CREB;Transcriptional activation of mitochondrial biogenesis;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;Loss of phosphorylation of MECP2 at T308;Regulation of MECP2 expression and activity;Negative regulation of NMDA receptor-mediated neuronal transmission |
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198 815 CAMK2A False True CaMK IV-mediated phosphorylation of CREB;HSF1-dependent transactivation;Trafficking of AMPA receptors;Ca2+ pathway;Unblocking of NMDA receptors, glutamate binding and activation;Phase 0 - rapid depolarisation;Ion homeostasis;RAF activation;Signaling by moderate kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF;Interferon gamma signaling;Regulation of MECP2 expression and activity;Ion transport by P-type ATPases;Negative regulation of NMDA receptor-mediated neuronal transmission;Long-term potentiation |
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199 816 CAMK2B False True CaMK IV-mediated phosphorylation of CREB;HSF1-dependent transactivation;Trafficking of AMPA receptors;Unblocking of NMDA receptors, glutamate binding and activation;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;Phase 0 - rapid depolarisation;Ion homeostasis;RAF activation;Signaling by moderate kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF;Interferon gamma signaling;Regulation of MECP2 expression and activity;Ion transport by P-type ATPases;Negative regulation of NMDA receptor-mediated neuronal transmission;Long-term potentiation |
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200 817 CAMK2D False True CaMK IV-mediated phosphorylation of CREB;HSF1-dependent transactivation;Trafficking of AMPA receptors;Unblocking of NMDA receptors, glutamate binding and activation;Phase 0 - rapid depolarisation;Ion homeostasis;RAF activation;Signaling by moderate kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF;Interferon gamma signaling;Regulation of MECP2 expression and activity;Ion transport by P-type ATPases;Negative regulation of NMDA receptor-mediated neuronal transmission;Long-term potentiation |
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201 818 CAMK2G False True CaMK IV-mediated phosphorylation of CREB;HSF1-dependent transactivation;Trafficking of AMPA receptors;Unblocking of NMDA receptors, glutamate binding and activation;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;Phase 0 - rapid depolarisation;Ion homeostasis;RAF activation;Signaling by moderate kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF;Interferon gamma signaling;Regulation of MECP2 expression and activity;Ion transport by P-type ATPases;Negative regulation of NMDA receptor-mediated neuronal transmission;Long-term potentiation |
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202 819 CAMLG False True NA |
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203 821 CANX False True Assembly of Viral Components at the Budding Site;MHC class II antigen presentation;Interleukin-35 Signalling;Calnexin/calreticulin cycle;Interleukin-27 signaling;Antigen Presentation: Folding, assembly and peptide loading of class I MHC;Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
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204 822 CAPG True True NA |
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205 823 CAPN1 True True Degradation of the extracellular matrix;Degradation of the extracellular matrix;Neutrophil degranulation;Formation of the cornified envelope;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models |
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206 824 CAPN2 False True Degradation of the extracellular matrix;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models |
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207 826 CAPNS1 False True Degradation of the extracellular matrix;Degradation of the extracellular matrix;Formation of the cornified envelope;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models |
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208 829 CAPZA1 False True MHC class II antigen presentation;HSP90 chaperone cycle for steroid hormone receptors (SHR);COPI-mediated anterograde transport;COPI-independent Golgi-to-ER retrograde traffic;Advanced glycosylation endproduct receptor signaling;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation;Factors involved in megakaryocyte development and platelet production;Factors involved in megakaryocyte development and platelet production |
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209 830 CAPZA2 False True MHC class II antigen presentation;HSP90 chaperone cycle for steroid hormone receptors (SHR);COPI-mediated anterograde transport;COPI-independent Golgi-to-ER retrograde traffic;Advanced glycosylation endproduct receptor signaling;Factors involved in megakaryocyte development and platelet production;Factors involved in megakaryocyte development and platelet production |
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210 831 CAST False True Degradation of the extracellular matrix;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models |
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211 832 CAPZB True True MHC class II antigen presentation;HSP90 chaperone cycle for steroid hormone receptors (SHR);COPI-mediated anterograde transport;COPI-independent Golgi-to-ER retrograde traffic;Factors involved in megakaryocyte development and platelet production;Factors involved in megakaryocyte development and platelet production |
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212 833 CARS False True Cytosolic tRNA aminoacylation |
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213 834 CASP1 False True NOD1/2 Signaling Pathway;Interleukin-1 processing;TP53 Regulates Transcription of Caspase Activators and Caspases;The NLRP3 inflammasome;The AIM2 inflammasome;The IPAF inflammasome;Interleukin-37 signaling |
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214 835 CASP2 False True NOD1/2 Signaling Pathway;NADE modulates death signalling;TP53 Regulates Transcription of Caspase Activators and Caspases |
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215 836 CASP3 False True Activation of caspases through apoptosome-mediated cleavage;SMAC (DIABLO) binds to IAPs ;SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ;Apoptotic cleavage of cellular proteins;SMAC, XIAP-regulated apoptotic response;Degradation of the extracellular matrix;Signaling by Hippo;NADE modulates death signalling;Activation of DNA fragmentation factor;Stimulation of the cell death response by PAK-2p34;Caspase-mediated cleavage of cytoskeletal proteins;Apoptotic cleavage of cell adhesion proteins;Caspase activation via Dependence Receptors in the absence of ligand;Caspase activation via Dependence Receptors in the absence of ligand;Other interleukin signaling |
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216 837 CASP4 False True NOD1/2 Signaling Pathway |
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217 840 CASP7 False True Activation of caspases through apoptosome-mediated cleavage;SMAC (DIABLO) binds to IAPs ;SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ;Apoptotic cleavage of cellular proteins;SMAC, XIAP-regulated apoptotic response;Caspase-mediated cleavage of cytoskeletal proteins |
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218 841 CASP8 False True Apoptotic cleavage of cellular proteins;Caspase activation via Death Receptors in the presence of ligand;NOD1/2 Signaling Pathway;TRIF-mediated programmed cell death;Caspase-mediated cleavage of cytoskeletal proteins;Regulation by c-FLIP;RIPK1-mediated regulated necrosis;CASP8 activity is inhibited;TNFR1-induced proapoptotic signaling;Regulation of TNFR1 signaling;CLEC7A/inflammasome pathway;Regulation of necroptotic cell death;Dimerization of procaspase-8;Activation, myristolyation of BID and translocation to mitochondria;Apoptotic execution phase;FasL/ CD95L signaling;TRAIL signaling;TLR3-mediated TICAM1-dependent programmed cell death;NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 |
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219 843 CASP10 False True TP53 Regulates Transcription of Caspase Activators and Caspases;FasL/ CD95L signaling;TRAIL signaling;NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 |
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220 847 CAT True True Detoxification of Reactive Oxygen Species;Neutrophil degranulation;Peroxisomal protein import;Peroxisomal protein import;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes |
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221 857 CAV1 False True Triglyceride catabolism;eNOS activation;NOSTRIN mediated eNOS trafficking;Basigin interactions;Disassembly of the destruction complex and recruitment of AXIN to the membrane;VEGFR2 mediated vascular permeability;FOXO-mediated transcription of cell cycle genes |
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222 865 CBFB False True RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs);Transcriptional regulation by RUNX2;Transcriptional regulation by RUNX2;RUNX1 regulates estrogen receptor mediated transcription;Regulation of RUNX1 Expression and Activity;RUNX1 regulates expression of components of tight junctions;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;RUNX1 regulates transcription of genes involved in differentiation of HSCs;RUNX1 regulates transcription of genes involved in differentiation of HSCs;RUNX1 regulates transcription of genes involved in differentiation of keratinocytes;RUNX1 regulates transcription of genes involved in differentiation of keratinocytes;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known;RUNX1 regulates transcription of genes involved in BCR signaling;RUNX1 regulates transcription of genes involved in differentiation of myeloid cells;RUNX1 regulates transcription of genes involved in interleukin signaling;RUNX1 regulates transcription of genes involved in WNT signaling;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;RUNX2 regulates osteoblast differentiation;RUNX2 regulates osteoblast differentiation;RUNX2 regulates chondrocyte maturation;RUNX2 regulates bone development;RUNX2 regulates genes involved in cell migration;RUNX2 regulates genes involved in cell migration;RUNX2 regulates genes involved in differentiation of myeloid cells;Regulation of RUNX3 expression and activity;RUNX3 Regulates Immune Response and Cell Migration;RUNX3 Regulates Immune Response and Cell Migration;RUNX3 regulates RUNX1-mediated transcription;RUNX3 regulates p14-ARF;Estrogen-dependent gene expression |
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223 867 CBL False True Interleukin-6 signaling;Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants;Spry regulation of FGF signaling;Regulation of KIT signaling;EGFR downregulation;TGF-beta receptor signaling activates SMADs;Constitutive Signaling by EGFRvIII;Negative regulation of FGFR1 signaling;Negative regulation of FGFR2 signaling;Negative regulation of FGFR3 signaling;Negative regulation of FGFR4 signaling;Negative regulation of MET activity;PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;InlB-mediated entry of Listeria monocytogenes into host cell;InlB-mediated entry of Listeria monocytogenes into host cell;Regulation of signaling by CBL;Regulation of signaling by CBL |
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224 871 SERPINH1 False True Collagen biosynthesis and modifying enzymes |
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225 875 CBS False True Cysteine formation from homocysteine;Metabolism of ingested SeMet, Sec, MeSec into H2Se |
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226 890 CCNA2 False True Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1;G0 and Early G1;Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Regulation of APC/C activators between G1/S and early anaphase;SCF(Skp2)-mediated degradation of p27/p21;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;Ub-specific processing proteases;Processing of DNA double-strand break ends;TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest;Regulation of TP53 Activity through Phosphorylation;Regulation of TP53 Degradation;G2 Phase;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Cyclin A/B1/B2 associated events during G2/M transition;Cyclin A/B1/B2 associated events during G2/M transition;p53-Dependent G1 DNA Damage Response;Cyclin A:Cdk2-associated events at S phase entry |
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227 891 CCNB1 False True E2F-enabled inhibition of pre-replication complex formation;Polo-like kinase mediated events;Golgi Cisternae Pericentriolar Stack Reorganization;APC/C:Cdc20 mediated degradation of Cyclin B;Regulation of APC/C activators between G1/S and early anaphase;Phosphorylation of the APC/C;Phosphorylation of Emi1;Condensation of Prophase Chromosomes;MASTL Facilitates Mitotic Progression;Resolution of Sister Chromatid Cohesion;Condensation of Prometaphase Chromosomes;Regulation of PLK1 Activity at G2/M Transition;Activation of NIMA Kinases NEK9, NEK6, NEK7;Nuclear Pore Complex (NPC) Disassembly;Depolymerisation of the Nuclear Lamina;TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest;Mitotic Prophase;Cyclin A/B1/B2 associated events during G2/M transition;G2/M DNA replication checkpoint;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;The role of GTSE1 in G2/M progression after G2 checkpoint;Transcriptional regulation by RUNX2 |
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228 892 CCNC False True PPARA activates gene expression;NOTCH1 Intracellular Domain Regulates Transcription;Generic Transcription Pathway;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Transcriptional regulation of white adipocyte differentiation;Transcriptional regulation of white adipocyte differentiation |
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229 900 CCNG1 False True Regulation of TP53 Degradation |
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230 908 CCT6A False True Prefoldin mediated transfer of substrate to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Folding of actin by CCT/TriC;Association of TriC/CCT with target proteins during biosynthesis;Association of TriC/CCT with target proteins during biosynthesis;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding |
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231 919 CD247 False True Nef and signal transduction;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Downstream TCR signaling;Phosphorylation of CD3 and TCR zeta chains;Translocation of ZAP-70 to Immunological synapse;Generation of second messenger molecules;FCGR activation;FCGR activation;Regulation of actin dynamics for phagocytic cup formation;Role of phospholipids in phagocytosis;PD-1 signaling |
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232 929 CD14 False True ER-Phagosome pathway;Caspase activation via Death Receptors in the presence of ligand;Toll Like Receptor 4 (TLR4) Cascade;Transfer of LPS from LBP carrier to CD14;MyD88:MAL(TIRAP) cascade initiated on plasma membrane;MyD88-independent TLR4 cascade ;Toll Like Receptor TLR1:TLR2 Cascade;Toll Like Receptor TLR6:TLR2 Cascade;TRIF-mediated programmed cell death;MyD88 deficiency (TLR2/4);IRAK4 deficiency (TLR2/4);Regulation of TLR by endogenous ligand;Neutrophil degranulation;Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon;IKK complex recruitment mediated by RIP1;TRAF6-mediated induction of TAK1 complex within TLR4 complex;IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |
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233 931 MS4A1 False True NA |
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234 950 SCARB2 False True Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis |
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235 956 ENTPD3 False True Phosphate bond hydrolysis by NTPDase proteins |
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236 960 CD44 False True Degradation of the extracellular matrix;Cell surface interactions at the vascular wall;Integrin cell surface interactions;Hyaluronan uptake and degradation;Neutrophil degranulation;Interferon gamma signaling |
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237 971 CD72 False True Other semaphorin interactions |
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238 975 CD81 False True Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of Complement cascade |
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239 983 CDK1 False True MAPK3 (ERK1) activation;E2F-enabled inhibition of pre-replication complex formation;Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1;Golgi Cisternae Pericentriolar Stack Reorganization;Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes;APC/C:Cdc20 mediated degradation of Cyclin B;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Regulation of APC/C activators between G1/S and early anaphase;Phosphorylation of the APC/C;Phosphorylation of Emi1;Condensation of Prophase Chromosomes;MASTL Facilitates Mitotic Progression;Resolution of Sister Chromatid Cohesion;Condensation of Prometaphase Chromosomes;Regulation of PLK1 Activity at G2/M Transition;Activation of NIMA Kinases NEK9, NEK6, NEK7;Nuclear Pore Complex (NPC) Disassembly;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Depolymerisation of the Nuclear Lamina;Activation of E2F1 target genes at G1/S;Anchoring of the basal body to the plasma membrane;MAPK6/MAPK4 signaling;Ovarian tumor domain proteases;TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest;Regulation of TP53 Degradation;Mitotic Prophase;Cyclin A/B1/B2 associated events during G2/M transition;Cyclin A/B1/B2 associated events during G2/M transition;G2/M DNA replication checkpoint;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;The role of GTSE1 in G2/M progression after G2 checkpoint;AURKA Activation by TPX2;Transcriptional regulation by RUNX2 |
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240 984 CDK11B False True Recruitment of mitotic centrosome proteins and complexes |
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241 988 CDC5L False True mRNA Splicing - Major Pathway |
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242 989 SEPT7 False True MAPK6/MAPK4 signaling |
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243 990 CDC6 False True Transcription of E2F targets under negative control by DREAM complex;Activation of ATR in response to replication stress;Activation of E2F1 target genes at G1/S;CDC6 association with the ORC:origin complex;CDT1 association with the CDC6:ORC:origin complex;Assembly of the pre-replicative complex;Orc1 removal from chromatin;Activation of the pre-replicative complex;CDK-mediated phosphorylation and removal of Cdc6 |
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244 993 CDC25A False True Transcription of E2F targets under negative control by DREAM complex;Polo-like kinase mediated events;Activation of ATR in response to replication stress;Ub-specific processing proteases;Cyclin E associated events during G1/S transition ;Cyclin A/B1/B2 associated events during G2/M transition;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Cyclin A:Cdk2-associated events at S phase entry;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models |
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245 994 CDC25B False True Cyclin A/B1/B2 associated events during G2/M transition;Cyclin A:Cdk2-associated events at S phase entry;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models |
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246 995 CDC25C False True Polo-like kinase mediated events;Activation of ATR in response to replication stress;RHO GTPases activate PKNs;TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest;TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain;Cyclin A/B1/B2 associated events during G2/M transition;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models |
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247 998 CDC42 False True GPVI-mediated activation cascade;EGFR downregulation;Rho GTPase cycle;Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;CDO in myogenesis;CDO in myogenesis;CD28 dependent Vav1 pathway;EPHB-mediated forward signaling;EPHB-mediated forward signaling;DCC mediated attractive signaling;Inactivation of CDC42 and RAC1;VEGFA-VEGFR2 Pathway;RHO GTPases activate KTN1;RHO GTPases activate IQGAPs;RHO GTPases activate PAKs;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate Formins;RHO GTPases Activate Formins;MAPK6/MAPK4 signaling;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation;G beta:gamma signalling through CDC42;Factors involved in megakaryocyte development and platelet production |
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248 999 CDH1 False True Degradation of the extracellular matrix;Degradation of the extracellular matrix;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Integrin cell surface interactions;Apoptotic cleavage of cell adhesion proteins;Adherens junctions interactions;RHO GTPases activate IQGAPs;InlA-mediated entry of Listeria monocytogenes into host cells |
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249 1003 CDH5 False True Adherens junctions interactions;VEGFR2 mediated vascular permeability |
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250 1017 CDK2 False True G0 and Early G1;Activation of ATR in response to replication stress;Regulation of APC/C activators between G1/S and early anaphase;SCF(Skp2)-mediated degradation of p27/p21;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;Processing of DNA double-strand break ends;TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest;Regulation of TP53 Activity through Phosphorylation;Regulation of TP53 Degradation;G2 Phase;Orc1 removal from chromatin;Activation of the pre-replicative complex;CDK-mediated phosphorylation and removal of Cdc6;Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes;Cyclin E associated events during G1/S transition ;Cyclin A/B1/B2 associated events during G2/M transition;p53-Dependent G1 DNA Damage Response;Cyclin A:Cdk2-associated events at S phase entry;PTK6 Regulates Cell Cycle;Meiotic recombination;Factors involved in megakaryocyte development and platelet production |
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251 1018 CDK3 False True NA |
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252 1019 CDK4 False True SCF(Skp2)-mediated degradation of p27/p21;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);Oncogene Induced Senescence;RMTs methylate histone arginines;Transcriptional regulation of white adipocyte differentiation;Ubiquitin-dependent degradation of Cyclin D1;Ubiquitin-dependent degradation of Cyclin D1;Cyclin D associated events in G1;PTK6 Regulates Cell Cycle;Transcriptional regulation by RUNX2;Meiotic recombination |
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253 1021 CDK6 False True Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);Oncogene Induced Senescence;Cyclin D associated events in G1;Regulation of RUNX1 Expression and Activity |
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254 1022 CDK7 False True Formation of RNA Pol II elongation complex ;Formation of the Early Elongation Complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of the HIV-1 Early Elongation Complex;RNA Pol II CTD phosphorylation and interaction with CE during HIV infection;HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;Formation of HIV-1 elongation complex containing HIV-1 Tat;Tat-mediated elongation of the HIV-1 transcript;NoRC negatively regulates rRNA expression;Formation of Incision Complex in GG-NER;RNA Polymerase II Pre-transcription Events;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;TP53 Regulates Transcription of DNA Repair Genes;RNA polymerase II transcribes snRNA genes;RNA polymerase II transcribes snRNA genes;Cyclin E associated events during G1/S transition ;Cyclin D associated events in G1;Cyclin A/B1/B2 associated events during G2/M transition;Cyclin A:Cdk2-associated events at S phase entry;mRNA Capping;RNA Polymerase I Transcription Initiation;RNA Polymerase I Promoter Escape;RNA Polymerase II Promoter Escape;RNA Polymerase I Chain Elongation;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase I Transcription Termination;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Elongation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Pol II CTD phosphorylation and interaction with CE;RUNX1 regulates transcription of genes involved in differentiation of HSCs |
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255 1025 CDK9 False True Formation of RNA Pol II elongation complex ;Formation of HIV elongation complex in the absence of HIV Tat;Formation of HIV-1 elongation complex containing HIV-1 Tat;Formation of HIV-1 elongation complex containing HIV-1 Tat;Pausing and recovery of Tat-mediated HIV elongation;Tat-mediated HIV elongation arrest and recovery;Tat-mediated elongation of the HIV-1 transcript;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;Interactions of Tat with host cellular proteins;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;RNA Polymerase II Pre-transcription Events;TP53 Regulates Transcription of DNA Repair Genes;RNA polymerase II transcribes snRNA genes;RNA polymerase II transcribes snRNA genes;RNA Polymerase II Transcription Elongation;Estrogen-dependent gene expression |
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256 1026 CDKN1A False True SCF(Skp2)-mediated degradation of p27/p21;AKT phosphorylates targets in the cytosol;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;Constitutive Signaling by AKT1 E17K in Cancer;Interleukin-4 and Interleukin-13 signaling;TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest;Cyclin E associated events during G1/S transition ;Cyclin D associated events in G1;p53-Dependent G1 DNA Damage Response;Cyclin A:Cdk2-associated events at S phase entry;Transcriptional activation of cell cycle inhibitor p21 ;The role of GTSE1 in G2/M progression after G2 checkpoint;TFAP2 (AP-2) family regulates transcription of cell cycle factors;Transcriptional regulation by RUNX2;RUNX3 regulates CDKN1A transcription;FOXO-mediated transcription of cell cycle genes |
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257 1027 CDKN1B False True SCF(Skp2)-mediated degradation of p27/p21;AKT phosphorylates targets in the cytosol;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;RHO GTPases activate CIT;Constitutive Signaling by AKT1 E17K in Cancer;TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest;Cyclin E associated events during G1/S transition ;Cyclin D associated events in G1;p53-Dependent G1 DNA Damage Response;Cyclin A:Cdk2-associated events at S phase entry;PTK6 Regulates Cell Cycle;FOXO-mediated transcription of cell cycle genes |
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258 1029 CDKN2A False True Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);Oncogene Induced Senescence;SUMOylation of DNA damage response and repair proteins;SUMOylation of transcription factors;Regulation of TP53 Degradation;Cyclin D associated events in G1;Stabilization of p53;Regulation of RUNX3 expression and activity |
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259 1039 CDR2 False True NA |
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260 1043 NA False True Post-translational modification: synthesis of GPI-anchored proteins |
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261 1053 CEBPE False True NA |
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262 1062 CENPE False True Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;COPI-dependent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;Kinesins |
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263 1070 CETN3 False True NA |
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264 1072 CFL1 False True Platelet degranulation ;Regulation of actin dynamics for phagocytic cup formation;EPHB-mediated forward signaling;Sema3A PAK dependent Axon repulsion;RHO GTPases Activate ROCKs;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation |
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265 1073 CFL2 False True NA |
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266 1075 CTSC False True COPII-mediated vesicle transport;MHC class II antigen presentation;Cargo concentration in the ER;Neutrophil degranulation |
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267 1080 CFTR False True ABC-family proteins mediated transport;RHO GTPases regulate CFTR trafficking;Defective CFTR causes cystic fibrosis;Ub-specific processing proteases;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis |
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268 1102 RCBTB2 False True NA |
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269 1104 RCC1 False True Rev-mediated nuclear export of HIV RNA;Nuclear import of Rev protein |
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270 1107 CHD3 False True HDACs deacetylate histones;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;SUMOylation of chromatin organization proteins;Regulation of TP53 Activity through Acetylation;RNA Polymerase I Transcription Initiation;Regulation of PTEN gene transcription;Regulation of PTEN gene transcription |
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271 1111 CHEK1 False True Signaling by SCF-KIT;Activation of ATR in response to replication stress;Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;TP53 Regulates Transcription of DNA Repair Genes;Regulation of TP53 Activity through Phosphorylation;G2/M DNA damage checkpoint;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;Transcriptional Regulation by E2F6 |
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272 1120 NA False True Synthesis of PC;Synthesis of PE |
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273 1130 LYST False True NA |
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274 1147 CHUK False True Activation of NF-kappaB in B cells;Activation of NF-kappaB in B cells;ER-Phagosome pathway;NOD1/2 Signaling Pathway;TICAM1, RIP1-mediated IKK complex recruitment ;RIP-mediated NFkB activation via ZBP1;AKT phosphorylates targets in the cytosol;Downstream TCR signaling;FCERI mediated NF-kB activation;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;IKBKB deficiency causes SCID;IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR);IkBA variant leads to EDA-ID;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Constitutive Signaling by AKT1 E17K in Cancer;NIK-->noncanonical NF-kB signaling;MAP3K8 (TPL2)-dependent MAPK1/3 activation;Interleukin-1 signaling;TRAF6 mediated NF-kB activation;NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10;IRAK1 recruits IKK complex;IKK complex recruitment mediated by RIP1;IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation |
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275 1152 CKB False True Creatine metabolism |
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276 1155 TBCB False True Post-chaperonin tubulin folding pathway |
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277 1159 CKMT1B False True Creatine metabolism |
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278 1160 CKMT2 False True Creatine metabolism |
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279 1173 AP2M1 False True Nef mediated downregulation of CD28 cell surface expression;Nef Mediated CD4 Down-regulation;Retrograde neurotrophin signalling;Retrograde neurotrophin signalling;Nef Mediated CD8 Down-regulation;Gap junction degradation;Formation of annular gap junctions;MHC class II antigen presentation;EPH-ephrin mediated repulsion of cells;Trafficking of GluR2-containing AMPA receptors;Recycling pathway of L1;Recycling pathway of L1;WNT5A-dependent internalization of FZD4;WNT5A-dependent internalization of FZD2, FZD5 and ROR2;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;VLDLR internalisation and degradation;LDL clearance |
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280 1182 CLCN3 False True Stimuli-sensing channels |
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281 1186 NA False True Stimuli-sensing channels |
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282 1196 CLK2 False True NA |
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283 1198 CLK3 False True NA |
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284 1207 CLNS1A False True snRNP Assembly |
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285 1211 CLTA False True Entry of Influenza Virion into Host Cell via Endocytosis;Retrograde neurotrophin signalling;Retrograde neurotrophin signalling;Gap junction degradation;Formation of annular gap junctions;MHC class II antigen presentation;EPH-ephrin mediated repulsion of cells;Lysosome Vesicle Biogenesis;Golgi Associated Vesicle Biogenesis;Recycling pathway of L1;Recycling pathway of L1;WNT5A-dependent internalization of FZD4;WNT5A-dependent internalization of FZD2, FZD5 and ROR2;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;VLDLR internalisation and degradation;LDL clearance |
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286 1212 CLTB False True Gap junction degradation;Formation of annular gap junctions;EPH-ephrin mediated repulsion of cells;Lysosome Vesicle Biogenesis;WNT5A-dependent internalization of FZD4;WNT5A-dependent internalization of FZD2, FZD5 and ROR2;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis |
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287 1213 CLTC False True Entry of Influenza Virion into Host Cell via Endocytosis;Retrograde neurotrophin signalling;Retrograde neurotrophin signalling;Gap junction degradation;Formation of annular gap junctions;MHC class II antigen presentation;EPH-ephrin mediated repulsion of cells;Lysosome Vesicle Biogenesis;Golgi Associated Vesicle Biogenesis;Recycling pathway of L1;Recycling pathway of L1;WNT5A-dependent internalization of FZD4;WNT5A-dependent internalization of FZD2, FZD5 and ROR2;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;VLDLR internalisation and degradation;LDL clearance |
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288 1244 ABCC2 False True ABC-family proteins mediated transport;Defective ABCC2 causes Dubin-Johnson syndrome |
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289 1277 COL1A1 False True GPVI-mediated activation cascade;Collagen degradation;Collagen degradation;Extracellular matrix organization;Collagen biosynthesis and modifying enzymes;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Assembly of collagen fibrils and other multimeric structures;Cell surface interactions at the vascular wall;Integrin cell surface interactions;Integrin cell surface interactions;Anchoring fibril formation;Crosslinking of collagen fibrils;Syndecan interactions;Non-integrin membrane-ECM interactions;ECM proteoglycans;ECM proteoglycans;Scavenging by Class A Receptors;GP1b-IX-V activation signalling;Platelet Adhesion to exposed collagen;Platelet Adhesion to exposed collagen;Platelet Aggregation (Plug Formation);MET activates PTK2 signaling;RUNX2 regulates osteoblast differentiation;Collagen chain trimerization |
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290 1278 COL1A2 False True GPVI-mediated activation cascade;Collagen degradation;Collagen degradation;Extracellular matrix organization;Collagen biosynthesis and modifying enzymes;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Assembly of collagen fibrils and other multimeric structures;Cell surface interactions at the vascular wall;Integrin cell surface interactions;Integrin cell surface interactions;Anchoring fibril formation;Crosslinking of collagen fibrils;Syndecan interactions;Non-integrin membrane-ECM interactions;ECM proteoglycans;ECM proteoglycans;Scavenging by Class A Receptors;GP1b-IX-V activation signalling;Interleukin-4 and Interleukin-13 signaling;Platelet Adhesion to exposed collagen;Platelet Adhesion to exposed collagen;Platelet Aggregation (Plug Formation);MET activates PTK2 signaling;Collagen chain trimerization |
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291 1296 COL8A2 False True Collagen degradation;Collagen degradation;Collagen biosynthesis and modifying enzymes;Assembly of collagen fibrils and other multimeric structures;Integrin cell surface interactions;Collagen chain trimerization |
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292 1314 COPA False True COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic |
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293 1315 COPB1 False True Neutrophil degranulation;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic |
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294 1326 MAP3K8 False True CD28 dependent PI3K/Akt signaling;MAP3K8 (TPL2)-dependent MAPK1/3 activation;MAP3K8 (TPL2)-dependent MAPK1/3 activation |
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295 1345 COX6C False True TP53 Regulates Metabolic Genes;Respiratory electron transport |
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296 1368 CPM False True Post-translational modification: synthesis of GPI-anchored proteins |
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297 1373 CPS1 False True Urea cycle |
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298 1374 CPT1A False True RORA activates gene expression;PPARA activates gene expression;Import of palmitoyl-CoA into the mitochondrial matrix;Signaling by Retinoic Acid |
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299 1387 CREBBP False True Regulation of gene expression by Hypoxia-inducible Factor;RORA activates gene expression;BMAL1:CLOCK,NPAS2 activates circadian gene expression;Pre-NOTCH Transcription and Translation;Pre-NOTCH Transcription and Translation;PPARA activates gene expression;PPARA activates gene expression;Formation of the beta-catenin:TCF transactivating complex;Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells;NOTCH1 Intracellular Domain Regulates Transcription;NOTCH1 Intracellular Domain Regulates Transcription;Transcriptional activation of mitochondrial biogenesis;Activation of gene expression by SREBF (SREBP);Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production;HATs acetylate histones;Attenuation phase;Notch-HLH transcription pathway;Transcriptional regulation of white adipocyte differentiation;Transcriptional regulation of white adipocyte differentiation;SUMOylation of transcription cofactors;Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha);Circadian Clock;Activation of anterior HOX genes in hindbrain development during early embryogenesis;CD209 (DC-SIGN) signaling;TP53 Regulates Transcription of Genes Involved in Cytochrome C Release;Activation of the TFAP2 (AP-2) family of transcription factors;RUNX1 regulates transcription of genes involved in differentiation of myeloid cells;RUNX3 regulates NOTCH signaling;RUNX3 regulates NOTCH signaling;NOTCH3 Intracellular Domain Regulates Transcription;NOTCH3 Intracellular Domain Regulates Transcription;NOTCH4 Intracellular Domain Regulates Transcription;Estrogen-dependent gene expression;TRAF3-dependent IRF activation pathway;TRAF6 mediated IRF7 activation;FOXO-mediated transcription of cell death genes;Regulation of FOXO transcriptional activity by acetylation;Regulation of FOXO transcriptional activity by acetylation |
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300 1396 CRIP1 False True NA |
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301 1398 CRK False True ARMS-mediated activation;ARMS-mediated activation;Downstream signal transduction;Regulation of actin dynamics for phagocytic cup formation;p130Cas linkage to MAPK signaling for integrins;VEGFA-VEGFR2 Pathway;PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases;MET activates RAP1 and RAC1;MET receptor recycling;Regulation of signaling by CBL |
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302 1399 CRKL False True Frs2-mediated activation;Frs2-mediated activation;Downstream signal transduction;MET activates RAP1 and RAC1;MET receptor recycling;Erythropoietin activates RAS;Erythropoietin activates RAS;Regulation of signaling by CBL |
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303 1408 CRY2 False True Circadian Clock |
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304 1409 CRYAA False True NA |
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305 1410 CRYAB False True HSF1-dependent transactivation |
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306 1415 CRYBB2 False True NA |
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307 1429 CRYZ False True NA |
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308 1431 CS False True Mitochondrial protein import;Citric acid cycle (TCA cycle) |
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309 1432 MAPK14 False True NOD1/2 Signaling Pathway;p38MAPK events;p38MAPK events;ERK/MAPK targets;Activation of PPARGC1A (PGC-1alpha) by phosphorylation;Oxidative Stress Induced Senescence;CDO in myogenesis;CDO in myogenesis;DSCAM interactions;ADP signalling through P2Y purinoceptor 1;Platelet sensitization by LDL;VEGFA-VEGFR2 Pathway;activated TAK1 mediates p38 MAPK activation;Activation of the AP-1 family of transcription factors;KSRP (KHSRP) binds and destabilizes mRNA;RHO GTPases Activate NADPH Oxidases;Neutrophil degranulation;Regulation of TP53 Activity through Phosphorylation |
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310 1434 CSE1L False True NA |
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311 1436 CSF1R False True Other interleukin signaling |
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312 1452 CSNK1A1 False True Degradation of beta-catenin by the destruction complex;Beta-catenin phosphorylation cascade;Disassembly of the destruction complex and recruitment of AXIN to the membrane;Disassembly of the destruction complex and recruitment of AXIN to the membrane;Misspliced GSK3beta mutants stabilize beta-catenin;S33 mutants of beta-catenin aren't phosphorylated;S37 mutants of beta-catenin aren't phosphorylated;S45 mutants of beta-catenin aren't phosphorylated;T41 mutants of beta-catenin aren't phosphorylated;APC truncation mutants have impaired AXIN binding;AXIN missense mutants destabilize the destruction complex;Truncations of AMER1 destabilize the destruction complex;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Activation of SMO;Activation of SMO |
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313 1453 CSNK1D False True COPII-mediated vesicle transport;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Circadian Clock;Anchoring of the basal body to the plasma membrane;Major pathway of rRNA processing in the nucleolus and cytosol;AURKA Activation by TPX2 |
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314 1457 CSNK2A1 False True Synthesis of PC;WNT mediated activation of DVL;Condensation of Prometaphase Chromosomes;Signal transduction by L1;Regulation of TP53 Activity through Phosphorylation;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding;Receptor Mediated Mitophagy;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known;Regulation of PTEN stability and activity |
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315 1459 CSNK2A2 False True Synthesis of PC;WNT mediated activation of DVL;Condensation of Prometaphase Chromosomes;Signal transduction by L1;Regulation of TP53 Activity through Phosphorylation;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding;Receptor Mediated Mitophagy;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known;Regulation of PTEN stability and activity |
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316 1465 CSRP1 False True MTF1 activates gene expression |
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317 1469 CST1 True True NA |
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318 1470 CST2 True True NA |
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319 1471 NA False True Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Neutrophil degranulation;Post-translational protein phosphorylation;Amyloid fiber formation |
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320 1472 CST4 True True NA |
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321 1474 NA True False NA |
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322 1475 CSTA True True Formation of the cornified envelope |
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323 1476 CSTB True True Neutrophil degranulation |
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324 1479 CSTF3 False True Cleavage of Growing Transcript in the Termination Region ;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Processing of Intronless Pre-mRNAs |
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325 1487 CTBP1 False True Deactivation of the beta-catenin transactivating complex;SUMOylation of transcription cofactors;Repression of WNT target genes;TCF7L2 mutants don't bind CTBP |
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326 1488 CTBP2 False True Repression of WNT target genes;TCF7L2 mutants don't bind CTBP |
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327 1495 CTNNA1 False True CDO in myogenesis;CDO in myogenesis;Adherens junctions interactions;VEGFR2 mediated vascular permeability;RHO GTPases activate IQGAPs |
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328 1499 CTNNB1 False True Degradation of beta-catenin by the destruction complex;Beta-catenin phosphorylation cascade;TCF dependent signaling in response to WNT;Formation of the beta-catenin:TCF transactivating complex;Formation of the beta-catenin:TCF transactivating complex;LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production;Apoptotic cleavage of cell adhesion proteins;CDO in myogenesis;CDO in myogenesis;Deactivation of the beta-catenin transactivating complex;Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1);Ca2+ pathway;Adherens junctions interactions;Binding of TCF/LEF:CTNNB1 to target gene promoters;Disassembly of the destruction complex and recruitment of AXIN to the membrane;Disassembly of the destruction complex and recruitment of AXIN to the membrane;VEGFR2 mediated vascular permeability;Misspliced GSK3beta mutants stabilize beta-catenin;S33 mutants of beta-catenin aren't phosphorylated;S37 mutants of beta-catenin aren't phosphorylated;S45 mutants of beta-catenin aren't phosphorylated;T41 mutants of beta-catenin aren't phosphorylated;RHO GTPases activate IQGAPs;InlA-mediated entry of Listeria monocytogenes into host cells;RUNX3 regulates WNT signaling |
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329 1500 CTNND1 False True Adherens junctions interactions;VEGFR2 mediated vascular permeability;InlA-mediated entry of Listeria monocytogenes into host cells |
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330 1503 CTPS1 False True Interconversion of nucleotide di- and triphosphates |
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331 1508 CTSB True True Collagen degradation;Trafficking and processing of endosomal TLR;Assembly of collagen fibrils and other multimeric structures;MHC class II antigen presentation;Neutrophil degranulation |
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332 1509 CTSD True True Collagen degradation;Metabolism of Angiotensinogen to Angiotensins;MHC class II antigen presentation;Neutrophil degranulation;Estrogen-dependent gene expression |
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333 1512 NA False True MHC class II antigen presentation;Surfactant metabolism;Neutrophil degranulation |
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334 1513 CTSK False True Collagen degradation;Degradation of the extracellular matrix;Activation of Matrix Metalloproteinases;Trafficking and processing of endosomal TLR;MHC class II antigen presentation;RUNX1 regulates transcription of genes involved in differentiation of keratinocytes |
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335 1514 CTSL False True Endosomal/Vacuolar pathway;Collagen degradation;Degradation of the extracellular matrix;Trafficking and processing of endosomal TLR;Assembly of collagen fibrils and other multimeric structures;MHC class II antigen presentation;RUNX1 regulates transcription of genes involved in differentiation of keratinocytes |
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336 1515 CTSV True True Endosomal/Vacuolar pathway;Degradation of the extracellular matrix;Activation of Matrix Metalloproteinases;Trafficking and processing of endosomal TLR;Assembly of collagen fibrils and other multimeric structures;MHC class II antigen presentation;RUNX1 regulates transcription of genes involved in differentiation of keratinocytes |
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337 1520 NA False True Endosomal/Vacuolar pathway;Degradation of the extracellular matrix;Degradation of the extracellular matrix;Trafficking and processing of endosomal TLR;Assembly of collagen fibrils and other multimeric structures;MHC class II antigen presentation;Neutrophil degranulation |
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338 1523 CUX1 False True Signaling by cytosolic FGFR1 fusion mutants;Signaling by FGFR1 in disease;Intra-Golgi traffic |
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339 1534 CYB561 False True NA |
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340 1537 CYC1 False True Mitochondrial protein import;Respiratory electron transport |
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341 1601 DAB2 False True Gap junction degradation;Formation of annular gap junctions;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis |
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342 1605 DAG1 False True Non-integrin membrane-ECM interactions;ECM proteoglycans;ECM proteoglycans;Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3;Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2;Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1;O-linked glycosylation;Regulation of expression of SLITs and ROBOs |
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343 1608 NA False True Effects of PIP2 hydrolysis |
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344 1613 DAPK3 False True Caspase activation via Dependence Receptors in the absence of ligand |
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345 1615 DARS False True SeMet incorporation into proteins;Cytosolic tRNA aminoacylation |
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346 1616 DAXX False True SUMOylation of transcription cofactors;Regulation of TP53 Degradation |
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347 1622 DBI False True Mitochondrial Fatty Acid Beta-Oxidation |
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348 1627 DBN1 False True NA |
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349 1630 DCC False True Netrin-1 signaling;Netrin-1 signaling;DSCAM interactions;DCC mediated attractive signaling;DCC mediated attractive signaling;Netrin mediated repulsion signals;Caspase activation via Dependence Receptors in the absence of ligand;Role of second messengers in netrin-1 signaling;Regulation of commissural axon pathfinding by SLIT and ROBO |
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350 1632 ECI1 False True mitochondrial fatty acid beta-oxidation of unsaturated fatty acids |
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351 1636 ACE False True Metabolism of Angiotensinogen to Angiotensins |
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352 1639 DCTN1 False True MHC class II antigen presentation;Regulation of PLK1 Activity at G2/M Transition;HSP90 chaperone cycle for steroid hormone receptors (SHR);Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;XBP1(S) activates chaperone genes;Anchoring of the basal body to the plasma membrane;COPI-mediated anterograde transport;COPI-independent Golgi-to-ER retrograde traffic;AURKA Activation by TPX2 |
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353 1642 DDB1 False True Recognition of DNA damage by PCNA-containing replication complex;DNA Damage Recognition in GG-NER;Formation of Incision Complex in GG-NER;Dual Incision in GG-NER;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Neddylation |
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354 1643 DDB2 False True Ub-specific processing proteases;DNA Damage Recognition in GG-NER;Formation of Incision Complex in GG-NER;Dual Incision in GG-NER;TP53 Regulates Transcription of DNA Repair Genes;Neddylation |
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355 1646 AKR1C2 False True Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol;Synthesis of bile acids and bile salts via 24-hydroxycholesterol;Synthesis of bile acids and bile salts via 27-hydroxycholesterol |
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356 1649 DDIT3 False True ATF4 activates genes;ATF6 (ATF6-alpha) activates chaperone genes;FOXO-mediated transcription of cell death genes;FOXO-mediated transcription of cell death genes |
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357 1650 DDOST False True SRP-dependent cotranslational protein targeting to membrane;Asparagine N-linked glycosylation;Neutrophil degranulation;Advanced glycosylation endproduct receptor signaling |
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358 1653 DDX1 False True tRNA processing in the nucleus |
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359 1654 DDX3X False True Neutrophil degranulation |
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360 1655 DDX5 False True SUMOylation of transcription cofactors;mRNA Splicing - Major Pathway;Estrogen-dependent gene expression |
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361 1659 DHX8 False True NA |
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362 1660 DHX9 False True RIP-mediated NFkB activation via ZBP1;DEx/H-box helicases activate type I IFN and inflammatory cytokines production ;mRNA Splicing - Major Pathway |
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363 1665 DHX15 False True mRNA Splicing - Major Pathway |
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364 1668 NA True False Defensins;Alpha-defensins |
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365 1674 DES False True Striated Muscle Contraction |
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366 1675 NA False True Platelet degranulation ;Alternative complement activation;Neutrophil degranulation |
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367 1676 DFFA False True Activation of DNA fragmentation factor |
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368 1727 CYB5R3 False True Vitamin C (ascorbate) metabolism;Phase I - Functionalization of compounds;Neutrophil degranulation |
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369 1736 DKC1 False True Telomere Extension By Telomerase;rRNA modification in the nucleus and cytosol |
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370 1737 DLAT False True Regulation of pyruvate dehydrogenase (PDH) complex;Glyoxylate metabolism and glycine degradation;Signaling by Retinoic Acid;Pyruvate metabolism |
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371 1743 DLST False True Glyoxylate metabolism and glycine degradation;Lysine catabolism;Citric acid cycle (TCA cycle) |
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372 1750 NA False True Regulation of RUNX2 expression and activity |
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373 1755 DMBT1 True True Surfactant metabolism |
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374 1756 DMD False True Non-integrin membrane-ECM interactions;Striated Muscle Contraction |
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375 1760 DMPK False True Ion homeostasis |
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376 1778 DYNC1H1 False True Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;Regulation of PLK1 Activity at G2/M Transition;HSP90 chaperone cycle for steroid hormone receptors (SHR);Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;RHO GTPases Activate Formins;Neutrophil degranulation;COPI-mediated anterograde transport;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;AURKA Activation by TPX2 |
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377 1785 DNM2 False True Toll Like Receptor 4 (TLR4) Cascade;Retrograde neurotrophin signalling;Gap junction degradation;Formation of annular gap junctions;NOSTRIN mediated eNOS trafficking;MHC class II antigen presentation;Lysosome Vesicle Biogenesis;Golgi Associated Vesicle Biogenesis;Recycling pathway of L1;Clathrin-mediated endocytosis |
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378 1801 DPH1 False True Synthesis of diphthamide-EEF2 |
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379 1806 DPYD False True Pyrimidine catabolism |
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380 1808 DPYSL2 False True CRMPs in Sema3A signaling;Recycling pathway of L1 |
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381 1823 DSC1 False True Neutrophil degranulation;Keratinization;Formation of the cornified envelope |
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382 1825 DSC3 True True Keratinization;Formation of the cornified envelope |
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383 1828 DSG1 True True Apoptotic cleavage of cell adhesion proteins;Neutrophil degranulation;Keratinization;Formation of the cornified envelope |
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384 1829 DSG2 False True Apoptotic cleavage of cell adhesion proteins;Keratinization;Formation of the cornified envelope |
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385 1832 DSP True True Apoptotic cleavage of cell adhesion proteins;Neutrophil degranulation;Keratinization;Formation of the cornified envelope |
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386 1838 DTNB False True NA |
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387 1854 DUT False True Interconversion of nucleotide di- and triphosphates |
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388 1857 DVL3 False True TCF dependent signaling in response to WNT;WNT mediated activation of DVL;PCP/CE pathway;PCP/CE pathway;Degradation of DVL;Disassembly of the destruction complex and recruitment of AXIN to the membrane;Disassembly of the destruction complex and recruitment of AXIN to the membrane;Negative regulation of TCF-dependent signaling by DVL-interacting proteins;RHO GTPases Activate Formins |
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389 1859 DYRK1A False True G0 and Early G1 |
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390 1861 TOR1A False True Cargo recognition for clathrin-mediated endocytosis |
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391 1874 E2F4 False True Transcription of E2F targets under negative control by DREAM complex;Transcription of E2F targets under negative control by DREAM complex;Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1;G0 and Early G1;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;Activation of E2F1 target genes at G1/S;Activation of E2F1 target genes at G1/S;TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest;Cyclin E associated events during G1/S transition ;Cyclin D associated events in G1;Cyclin A:Cdk2-associated events at S phase entry |
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392 1890 TYMP True True Pyrimidine salvage;Pyrimidine catabolism |
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393 1891 ECH1 False True Peroxisomal protein import;Peroxisomal protein import |
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394 1892 ECHS1 False True Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA;Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA;Beta oxidation of octanoyl-CoA to hexanoyl-CoA;Beta oxidation of hexanoyl-CoA to butanoyl-CoA;Beta oxidation of butanoyl-CoA to acetyl-CoA |
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395 1902 LPAR1 False True G alpha (q) signalling events;G alpha (i) signalling events;Lysosphingolipid and LPA receptors |
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396 1915 EEF1A1 False True Eukaryotic Translation Elongation;Eukaryotic Translation Elongation;Peptide chain elongation;HSF1 activation;Neutrophil degranulation;Protein methylation |
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397 1917 EEF1A2 False True Eukaryotic Translation Elongation |
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398 1933 EEF1B2 False True Eukaryotic Translation Elongation |
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399 1936 EEF1D False True Eukaryotic Translation Elongation |
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400 1937 EEF1G True True Eukaryotic Translation Elongation |
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401 1938 EEF2 True True Peptide chain elongation;Peptide chain elongation;Uptake and function of diphtheria toxin;Synthesis of diphthamide-EEF2;Synthesis of diphthamide-EEF2;Neutrophil degranulation;Protein methylation |
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402 1956 EGFR False True Signaling by ERBB2;Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants;Signaling by ERBB4;SHC1 events in ERBB2 signaling;SHC1 events in ERBB2 signaling;PLCG1 events in ERBB2 signaling;PIP3 activates AKT signaling;Signaling by EGFR;GRB2 events in EGFR signaling;GAB1 signalosome;SHC1 events in EGFR signaling;EGFR downregulation;GRB2 events in ERBB2 signaling;PI3K events in ERBB2 signaling;EGFR interacts with phospholipase C-gamma;EGFR Transactivation by Gastrin;Constitutive Signaling by Aberrant PI3K in Cancer;Signal transduction by L1;Constitutive Signaling by EGFRvIII;Inhibition of Signaling by Overexpressed EGFR;RAF/MAP kinase cascade;ERBB2 Regulates Cell Motility;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;ERBB2 Activates PTK6 Signaling;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;PTK6 promotes HIF1A stabilization;Downregulation of ERBB2 signaling;TFAP2 (AP-2) family regulates transcription of growth factors and their receptors;NOTCH3 Activation and Transmission of Signal to the Nucleus |
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403 1958 EGR1 False True Regulation of PTEN gene transcription;Regulation of PTEN gene transcription;Interferon alpha/beta signaling |
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404 1962 EHHADH False True Beta-oxidation of very long chain fatty acids;Peroxisomal protein import;Peroxisomal protein import |
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405 1964 EIF1AX False True L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit |
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406 1965 EIF2S1 False True L13a-mediated translational silencing of Ceruloplasmin expression;PERK regulates gene expression;ABC-family proteins mediated transport;Translation initiation complex formation;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Recycling of eIF2:GDP |
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407 1967 EIF2B1 False True Recycling of eIF2:GDP |
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408 1969 EPHA2 False True EPH-Ephrin signaling;EPH-Ephrin signaling;EPHA-mediated growth cone collapse;EPHA-mediated growth cone collapse;EPH-ephrin mediated repulsion of cells;EPH-ephrin mediated repulsion of cells |
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409 1973 EIF4A1 True True ISG15 antiviral mechanism;L13a-mediated translational silencing of Ceruloplasmin expression;Deadenylation of mRNA;Translation initiation complex formation;Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit |
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410 1974 EIF4A2 False True ISG15 antiviral mechanism;L13a-mediated translational silencing of Ceruloplasmin expression;Deadenylation of mRNA;Translation initiation complex formation;Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit |
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411 1975 EIF4B False True L13a-mediated translational silencing of Ceruloplasmin expression;mTORC1-mediated signalling;Deadenylation of mRNA;Translation initiation complex formation;Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit |
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412 1977 EIF4E False True ISG15 antiviral mechanism;L13a-mediated translational silencing of Ceruloplasmin expression;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;mTORC1-mediated signalling;Deadenylation of mRNA;Translation initiation complex formation;Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit |
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413 1978 EIF4EBP1 False True mTORC1-mediated signalling;Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
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414 1979 EIF4EBP2 False True NA |
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415 1981 EIF4G1 False True ISG15 antiviral mechanism;L13a-mediated translational silencing of Ceruloplasmin expression;mTORC1-mediated signalling;Deadenylation of mRNA;AUF1 (hnRNP D0) binds and destabilizes mRNA;Translation initiation complex formation;Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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416 1982 EIF4G2 False True ISG15 antiviral mechanism |
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417 1983 EIF5 False True Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit |
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418 1984 EIF5A False True Hypusine synthesis from eIF5A-lysine |
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419 1992 SERPINB1 True True Neutrophil degranulation |
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420 1994 ELAVL1 False True HuR (ELAVL1) binds and stabilizes mRNA;mRNA Splicing - Major Pathway |
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421 2001 ELF5 False True NA |
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422 2010 EMD False True Clearance of Nuclear Envelope Membranes from Chromatin;Initiation of Nuclear Envelope Reformation;Depolymerisation of the Nuclear Lamina |
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423 2011 MARK2 False True NA |
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424 2017 CTTN False True RHO GTPases activate PAKs;Clathrin-mediated endocytosis |
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425 2021 ENDOG False True NA |
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426 2023 ENO1 True True Glycolysis;Gluconeogenesis |
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427 2026 ENO2 False True Glycolysis;Gluconeogenesis |
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428 2027 ENO3 False True Glycolysis;Gluconeogenesis |
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429 2033 EP300 False True Regulation of gene expression by Hypoxia-inducible Factor;RORA activates gene expression;RORA activates gene expression;Polo-like kinase mediated events;Pre-NOTCH Transcription and Translation;Pre-NOTCH Transcription and Translation;PPARA activates gene expression;Formation of the beta-catenin:TCF transactivating complex;Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells;NOTCH1 Intracellular Domain Regulates Transcription;NOTCH1 Intracellular Domain Regulates Transcription;NOTCH2 intracellular domain regulates transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production;HATs acetylate histones;Attenuation phase;Transcriptional regulation of white adipocyte differentiation;Transcriptional regulation of white adipocyte differentiation;SUMOylation of transcription cofactors;Circadian Clock;Circadian Clock;B-WICH complex positively regulates rRNA expression;Activation of anterior HOX genes in hindbrain development during early embryogenesis;CD209 (DC-SIGN) signaling;Metalloprotease DUBs;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest;Regulation of TP53 Activity through Acetylation;Regulation of TP53 Activity through Methylation;PI5P Regulates TP53 Acetylation;Activation of the TFAP2 (AP-2) family of transcription factors;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known;RUNX3 regulates NOTCH signaling;RUNX3 regulates NOTCH signaling;Regulation of RUNX3 expression and activity;RUNX3 regulates p14-ARF;NOTCH3 Intracellular Domain Regulates Transcription;NOTCH3 Intracellular Domain Regulates Transcription;NOTCH4 Intracellular Domain Regulates Transcription;Estrogen-dependent gene expression;TRAF3-dependent IRF activation pathway;TRAF6 mediated IRF7 activation;FOXO-mediated transcription of cell death genes;Regulation of FOXO transcriptional activity by acetylation;Regulation of FOXO transcriptional activity by acetylation |
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430 2034 EPAS1 False True Regulation of gene expression by Hypoxia-inducible Factor;Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Transcriptional regulation of pluripotent stem cells;PTK6 Expression;Neddylation |
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431 2036 EPB41L1 False True Trafficking of AMPA receptors;Neurexins and neuroligins |
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432 2037 EPB41L2 False True Neurexins and neuroligins |
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433 2040 STOM False True Stimuli-sensing channels;Neutrophil degranulation |
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434 2041 EPHA1 False True EPH-Ephrin signaling;EPH-Ephrin signaling;POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation;EPHA-mediated growth cone collapse;EPHA-mediated growth cone collapse;EPH-ephrin mediated repulsion of cells;EPH-ephrin mediated repulsion of cells |
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435 2043 EPHA4 False True EPH-Ephrin signaling;EPH-Ephrin signaling;EPHA-mediated growth cone collapse;EPHA-mediated growth cone collapse;EPH-ephrin mediated repulsion of cells;EPH-ephrin mediated repulsion of cells |
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436 2047 EPHB1 False True EPH-Ephrin signaling;EPH-Ephrin signaling;EPHB-mediated forward signaling;EPHB-mediated forward signaling;Ephrin signaling;Ephrin signaling;EPH-ephrin mediated repulsion of cells |
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437 2051 EPHB6 False True EPH-Ephrin signaling;EPH-Ephrin signaling;EPHB-mediated forward signaling;EPHB-mediated forward signaling;Ephrin signaling;Ephrin signaling;EPH-ephrin mediated repulsion of cells |
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438 2054 STX2 False True NA |
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439 2058 EPRS False True SeMet incorporation into proteins;Cytosolic tRNA aminoacylation;tRNA modification in the nucleus and cytosol |
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440 2060 EPS15 False True EGFR downregulation;Negative regulation of MET activity;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;InlB-mediated entry of Listeria monocytogenes into host cell |
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441 2064 ERBB2 False True Signaling by ERBB2;SHC1 events in ERBB2 signaling;SHC1 events in ERBB2 signaling;PLCG1 events in ERBB2 signaling;PIP3 activates AKT signaling;GRB7 events in ERBB2 signaling;Downregulation of ERBB2:ERBB3 signaling;GRB2 events in ERBB2 signaling;GRB2 events in ERBB2 signaling;PI3K events in ERBB2 signaling;Constitutive Signaling by Aberrant PI3K in Cancer;Sema4D induced cell migration and growth-cone collapse;RAF/MAP kinase cascade;ERBB2 Regulates Cell Motility;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;ERBB2 Activates PTK6 Signaling;Downregulation of ERBB2 signaling;TFAP2 (AP-2) family regulates transcription of growth factors and their receptors |
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442 2065 ERBB3 False True Signaling by ERBB2;Signaling by ERBB4;SHC1 events in ERBB2 signaling;SHC1 events in ERBB2 signaling;PIP3 activates AKT signaling;GRB7 events in ERBB2 signaling;Downregulation of ERBB2:ERBB3 signaling;PI3K events in ERBB2 signaling;Constitutive Signaling by Aberrant PI3K in Cancer;RAF/MAP kinase cascade;ERBB2 Regulates Cell Motility;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;ERBB2 Activates PTK6 Signaling;Downregulation of ERBB2 signaling |
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443 2066 ERBB4 False True Signaling by ERBB2;Signaling by ERBB4;SHC1 events in ERBB2 signaling;SHC1 events in ERBB2 signaling;PI3K events in ERBB4 signaling;SHC1 events in ERBB4 signaling;Nuclear signaling by ERBB4;Nuclear signaling by ERBB4;Downregulation of ERBB4 signaling;PIP3 activates AKT signaling;GRB2 events in ERBB2 signaling;PI3K events in ERBB2 signaling;Constitutive Signaling by Aberrant PI3K in Cancer;RAF/MAP kinase cascade;ERBB2 Regulates Cell Motility;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;ERBB2 Activates PTK6 Signaling;Downregulation of ERBB2 signaling;Estrogen-dependent gene expression;Long-term potentiation |
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444 2073 ERCC5 False True Formation of Incision Complex in GG-NER;Dual Incision in GG-NER;Dual incision in TC-NER |
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445 2078 ERG False True NA |
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446 2079 ERH False True NA |
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447 2081 ERN1 False True IRE1alpha activates chaperones;IRE1alpha activates chaperones |
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448 2091 FBL False True rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol |
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449 2098 ESD False True Glutathione conjugation |
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450 2099 ESR1 False True Nuclear signaling by ERBB4;PIP3 activates AKT signaling;Constitutive Signaling by Aberrant PI3K in Cancer;Nuclear Receptor transcription pathway;SUMOylation of intracellular receptors;Ovarian tumor domain proteases;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;TFAP2 (AP-2) family regulates transcription of growth factors and their receptors;RUNX1 regulates estrogen receptor mediated transcription;ESR-mediated signaling;RUNX1 regulates transcription of genes involved in WNT signaling;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Estrogen-dependent gene expression |
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451 2103 ESRRB False True Nuclear Receptor transcription pathway |
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452 2107 ETF1 False True Eukaryotic Translation Termination;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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453 2108 ETFA False True Respiratory electron transport |
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454 2109 ETFB False True Respiratory electron transport;Protein methylation |
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455 2125 EVPL False True Formation of the cornified envelope |
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456 2130 EWSR1 False True NA |
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457 2147 F2 False True Intrinsic Pathway of Fibrin Clot Formation;Common Pathway of Fibrin Clot Formation;Gamma-carboxylation of protein precursors;Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus;Removal of aminoterminal propeptides from gamma-carboxylated proteins;Cell surface interactions at the vascular wall;Peptide ligand-binding receptors;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);G alpha (q) signalling events;Thrombin signalling through proteinase activated receptors (PARs);Platelet Aggregation (Plug Formation);Regulation of Complement cascade |
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458 2149 F2R False True Common Pathway of Fibrin Clot Formation;Peptide ligand-binding receptors;G alpha (q) signalling events;Thrombin signalling through proteinase activated receptors (PARs);Thrombin signalling through proteinase activated receptors (PARs) |
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459 2150 F2RL1 False True Peptide ligand-binding receptors;G alpha (q) signalling events |
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460 2155 F7 False True BMAL1:CLOCK,NPAS2 activates circadian gene expression;Extrinsic Pathway of Fibrin Clot Formation;Gamma-carboxylation of protein precursors;Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus;Removal of aminoterminal propeptides from gamma-carboxylated proteins |
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461 2170 FABP3 False True Triglyceride catabolism |
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462 2171 FABP5 True True Triglyceride catabolism;Signaling by Retinoic Acid;Neutrophil degranulation |
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463 2173 FABP7 False True Triglyceride catabolism;NOTCH3 Intracellular Domain Regulates Transcription |
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464 2175 FANCA False True Fanconi Anemia Pathway |
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465 2176 FANCC False True Fanconi Anemia Pathway;TP53 Regulates Transcription of DNA Repair Genes |
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466 2177 FANCD2 False True Fanconi Anemia Pathway;TP53 Regulates Transcription of DNA Repair Genes |
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467 2184 FAH False True Phenylalanine and tyrosine catabolism |
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468 2185 PTK2B False True Signal regulatory protein family interactions;VEGFA-VEGFR2 Pathway;Interleukin-2 signaling |
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469 2187 FANCB False True Fanconi Anemia Pathway |
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470 2189 FANCG False True Fanconi Anemia Pathway |
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471 2193 FARSA False True Cytosolic tRNA aminoacylation |
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472 2194 FASN False True ChREBP activates metabolic gene expression;Vitamin B5 (pantothenate) metabolism;Activation of gene expression by SREBF (SREBP);Fatty acyl-CoA biosynthesis;Fatty acyl-CoA biosynthesis |
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473 2202 EFEMP1 False True Molecules associated with elastic fibres;Molecules associated with elastic fibres |
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474 2203 FBP1 False True Gluconeogenesis |
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475 2205 FCER1A False True Fc epsilon receptor (FCERI) signaling;Fc epsilon receptor (FCERI) signaling;Role of LAT2/NTAL/LAB on calcium mobilization;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;FCERI mediated Ca+2 mobilization;FCERI mediated NF-kB activation |
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476 2207 FCER1G False True GPVI-mediated activation cascade;Cell surface interactions at the vascular wall;Fc epsilon receptor (FCERI) signaling;Fc epsilon receptor (FCERI) signaling;Role of LAT2/NTAL/LAB on calcium mobilization;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;FCERI mediated Ca+2 mobilization;FCERI mediated NF-kB activation;Dectin-2 family;Dectin-2 family;Neutrophil degranulation;Platelet Adhesion to exposed collagen |
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477 2217 FCGRT False True NA |
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478 2222 FDFT1 False True Cholesterol biosynthesis;PPARA activates gene expression;Activation of gene expression by SREBF (SREBP) |
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479 2224 FDPS False True Cholesterol biosynthesis;Activation of gene expression by SREBF (SREBP) |
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480 2237 FEN1 False True POLB-Dependent Long Patch Base Excision Repair;Early Phase of HIV Life Cycle;Removal of the Flap Intermediate from the C-strand;PCNA-Dependent Long Patch Base Excision Repair;HDR through MMEJ (alt-NHEJ);Removal of the Flap Intermediate |
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481 2241 FER False True Signaling by SCF-KIT |
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482 2242 FES False True Signaling by SCF-KIT;Sema3A PAK dependent Axon repulsion;SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion;CRMPs in Sema3A signaling |
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483 2243 FGA False True Platelet degranulation ;Common Pathway of Fibrin Clot Formation;Integrin cell surface interactions;Integrin alphaIIb beta3 signaling;GRB2:SOS provides linkage to MAPK signaling for Integrins ;p130Cas linkage to MAPK signaling for integrins;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);MAP2K and MAPK activation;Regulation of TLR by endogenous ligand;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF;Post-translational protein phosphorylation;Amyloid fiber formation |
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484 2257 FGF12 False True Phase 0 - rapid depolarisation |
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485 2260 FGFR1 False True PI3K Cascade;PIP3 activates AKT signaling;Signaling by FGFR1 amplification mutants;Signaling by activated point mutants of FGFR1;FGFR1b ligand binding and activation;FGFR1c ligand binding and activation;FGFR1c and Klotho ligand binding and activation;Constitutive Signaling by Aberrant PI3K in Cancer;NCAM signaling for neurite out-growth;Signal transduction by L1;Phospholipase C-mediated cascade: FGFR1;Downstream signaling of activated FGFR1;SHC-mediated cascade:FGFR1;PI-3K cascade:FGFR1;FRS-mediated FGFR1 signaling;Negative regulation of FGFR1 signaling;Signaling by FGFR1 in disease;RAF/MAP kinase cascade;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Signaling by plasma membrane FGFR1 fusions |
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486 2261 FGFR3 False True PI3K Cascade;PIP3 activates AKT signaling;Signaling by activated point mutants of FGFR3;FGFR3b ligand binding and activation;FGFR3c ligand binding and activation;FGFR3 mutant receptor activation;t(4;14) translocations of FGFR3;Constitutive Signaling by Aberrant PI3K in Cancer;Phospholipase C-mediated cascade; FGFR3;SHC-mediated cascade:FGFR3;FRS-mediated FGFR3 signaling;PI-3K cascade:FGFR3;Negative regulation of FGFR3 signaling;RAF/MAP kinase cascade;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Signaling by FGFR3 fusions in cancer;Signaling by FGFR3 point mutants in cancer |
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487 2268 FGR False True FCGR activation;Platelet sensitization by LDL;Neutrophil degranulation |
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488 2271 FH False True Citric acid cycle (TCA cycle) |
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489 2273 FHL1 False True NA |
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490 2274 FHL2 False True PPARA activates gene expression |
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491 2280 FKBP1A False True Calcineurin activates NFAT;TGF-beta receptor signaling activates SMADs;TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);TGFBR2 Kinase Domain Mutants in Cancer;TGFBR1 KD Mutants in Cancer;TGFBR1 LBD Mutants in Cancer |
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492 2281 FKBP1B False True Stimuli-sensing channels;Ion homeostasis |
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493 2286 FKBP2 False True NA |
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494 2288 FKBP4 False True HSP90 chaperone cycle for steroid hormone receptors (SHR);Attenuation phase;ESR-mediated signaling;Estrogen-dependent gene expression |
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495 2289 FKBP5 False True HSP90 chaperone cycle for steroid hormone receptors (SHR);ESR-mediated signaling;MECP2 regulates neuronal receptors and channels |
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496 2296 FOXC1 False True NA |
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497 2305 FOXM1 False True Polo-like kinase mediated events;Cyclin A/B1/B2 associated events during G2/M transition |
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498 2308 FOXO1 False True AKT phosphorylates targets in the nucleus;Regulation of gene expression in beta cells;AKT-mediated inactivation of FOXO1A;Constitutive Signaling by AKT1 E17K in Cancer;MAPK6/MAPK4 signaling;Interleukin-4 and Interleukin-13 signaling;Regulation of localization of FOXO transcription factors;FOXO-mediated transcription of cell death genes;FOXO-mediated transcription of cell death genes;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes;Regulation of FOXO transcriptional activity by acetylation;Regulation of FOXO transcriptional activity by acetylation;FOXO-mediated transcription of cell cycle genes;FOXO-mediated transcription of cell cycle genes |
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499 2309 FOXO3 False True Signaling by NODAL;AKT phosphorylates targets in the nucleus;Constitutive Signaling by AKT1 E17K in Cancer;MAPK6/MAPK4 signaling;Interleukin-4 and Interleukin-13 signaling;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;RUNX3 regulates BCL2L11 (BIM) transcription;Regulation of localization of FOXO transcription factors;FOXO-mediated transcription of cell death genes;FOXO-mediated transcription of cell death genes;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes;Regulation of FOXO transcriptional activity by acetylation;FOXO-mediated transcription of cell cycle genes;FOXO-mediated transcription of cell cycle genes |
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500 2312 NA True False Formation of the cornified envelope |
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501 2314 FLII False True NA |
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502 2316 FLNA False True Platelet degranulation ;GP1b-IX-V activation signalling;Cell-extracellular matrix interactions;RHO GTPases activate PAKs;OAS antiviral response |
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503 2317 FLNB True True ISG15 antiviral mechanism |
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504 2318 FLNC False True Cell-extracellular matrix interactions |
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505 2319 FLOT2 False True Synaptic adhesion-like molecules |
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506 2324 FLT4 False True VEGF binds to VEGFR leading to receptor dimerization;NOTCH4 Intracellular Domain Regulates Transcription |
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507 2335 FN1 False True Platelet degranulation ;Degradation of the extracellular matrix;Degradation of the extracellular matrix;Extracellular matrix organization;Fibronectin matrix formation;Cell surface interactions at the vascular wall;Molecules associated with elastic fibres;Integrin cell surface interactions;Syndecan interactions;Non-integrin membrane-ECM interactions;ECM proteoglycans;Integrin alphaIIb beta3 signaling;GRB2:SOS provides linkage to MAPK signaling for Integrins ;p130Cas linkage to MAPK signaling for integrins;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);MAP2K and MAPK activation;Interleukin-4 and Interleukin-13 signaling;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF;MET activates PTK2 signaling;Post-translational protein phosphorylation |
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508 2339 FNTA False True Apoptotic cleavage of cellular proteins;Inactivation, recovery and regulation of the phototransduction cascade |
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509 2342 FNTB False True Inactivation, recovery and regulation of the phototransduction cascade |
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510 2356 NA False True Metabolism of folate and pterines |
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511 2357 FPR1 False True G alpha (i) signalling events;Formyl peptide receptors bind formyl peptides and many other ligands;Interleukin-10 signaling;Neutrophil degranulation |
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512 2444 FRK False True Neutrophil degranulation;Regulation of PTEN stability and activity |
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513 2475 MTOR False True PIP3 activates AKT signaling;Macroautophagy;mTOR signalling;mTORC1-mediated signalling;HSF1-dependent transactivation;Energy dependent regulation of mTOR by LKB1-AMPK;CD28 dependent PI3K/Akt signaling;VEGFR2 mediated vascular permeability;TP53 Regulates Metabolic Genes;Constitutive Signaling by AKT1 E17K in Cancer;Regulation of TP53 Degradation;Regulation of PTEN gene transcription |
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514 2495 FTH1 False True Scavenging by Class A Receptors;Golgi Associated Vesicle Biogenesis;Neutrophil degranulation;Iron uptake and transport |
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515 2521 FUS False True mRNA Splicing - Major Pathway |
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516 2534 FYN False True GPVI-mediated activation cascade;Signaling by ERBB2;PIP3 activates AKT signaling;Signaling by SCF-KIT;Signaling by SCF-KIT;Regulation of KIT signaling;Nef and signal transduction;Cell surface interactions at the vascular wall;FCGR activation;PECAM1 interactions;Constitutive Signaling by Aberrant PI3K in Cancer;DAP12 signaling;DAP12 signaling;EPH-Ephrin signaling;Role of LAT2/NTAL/LAB on calcium mobilization;Nephrin family interactions;Nephrin family interactions;NCAM signaling for neurite out-growth;NCAM signaling for neurite out-growth;CD28 co-stimulation;CD28 dependent PI3K/Akt signaling;CD28 dependent Vav1 pathway;CTLA4 inhibitory signaling;EPHB-mediated forward signaling;EPHB-mediated forward signaling;EPHA-mediated growth cone collapse;EPHA-mediated growth cone collapse;Ephrin signaling;Ephrin signaling;EPH-ephrin mediated repulsion of cells;Sema3A PAK dependent Axon repulsion;SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion;SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion;CRMPs in Sema3A signaling;CRMPs in Sema3A signaling;DCC mediated attractive signaling;DCC mediated attractive signaling;VEGFA-VEGFR2 Pathway;Dectin-2 family;CD209 (DC-SIGN) signaling;RAF/MAP kinase cascade;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Platelet Adhesion to exposed collagen;Reelin signalling pathway;Activated NTRK2 signals through FYN;NTRK2 activates RAC1;NTRK2 activates RAC1;Regulation of signaling by CBL;Regulation of signaling by CBL;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
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517 2535 FZD2 False True TCF dependent signaling in response to WNT;Class B/2 (Secretin family receptors);Ca2+ pathway;Ca2+ pathway;Asymmetric localization of PCP proteins;Disassembly of the destruction complex and recruitment of AXIN to the membrane;Disassembly of the destruction complex and recruitment of AXIN to the membrane;WNT5A-dependent internalization of FZD2, FZD5 and ROR2 |
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518 2539 G6PD False True TP53 Regulates Metabolic Genes;Pentose phosphate pathway |
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519 2547 XRCC6 False True 2-LTR circle formation;Cytosolic sensors of pathogen-associated DNA ;IRF3-mediated induction of type I IFN;Nonhomologous End-Joining (NHEJ);Neutrophil degranulation |
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520 2548 GAA False True Glycogen storage disease type II (GAA);Neutrophil degranulation;Glycogen breakdown (glycogenolysis) |
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521 2549 GAB1 False True PI3K Cascade;Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants;PIP3 activates AKT signaling;GAB1 signalosome;PI3K events in ERBB2 signaling;Constitutive Signaling by Aberrant PI3K in Cancer;Constitutive Signaling by EGFRvIII;PI-3K cascade:FGFR1;PI-3K cascade:FGFR2;PI-3K cascade:FGFR3;PI-3K cascade:FGFR4;Signaling by FGFR2 in disease;Signaling by FGFR4 in disease;Signaling by FGFR1 in disease;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;MET activates PI3K/AKT signaling;Signaling by FGFR3 fusions in cancer;Signaling by FGFR3 point mutants in cancer;RET signaling;MET activates PTPN11;MET activates RAP1 and RAC1;MET receptor recycling;Erythropoietin activates Phosphoinositide-3-kinase (PI3K);Activated NTRK2 signals through PI3K |
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522 2550 GABBR1 False True Activation of G protein gated Potassium channels;G alpha (i) signalling events;Class C/3 (Metabotropic glutamate/pheromone receptors);GABA B receptor activation;Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
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523 2553 GABPB1 False True Transcriptional activation of mitochondrial biogenesis |
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524 2560 GABRB1 False True GABA A receptor activation;GABA receptor activation |
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525 2580 GAK False True Golgi Associated Vesicle Biogenesis;Clathrin-mediated endocytosis |
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526 2590 GALNT2 False True COPI-independent Golgi-to-ER retrograde traffic;O-linked glycosylation of mucins |
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527 2597 GAPDH True True Glycolysis;Gluconeogenesis |
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528 2617 GARS False True Cytosolic tRNA aminoacylation;Mitochondrial tRNA aminoacylation |
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529 2618 GART False True Purine ribonucleoside monophosphate biosynthesis |
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530 2620 GAS2 False True Caspase-mediated cleavage of cytoskeletal proteins |
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531 2623 GATA1 False True RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Factors involved in megakaryocyte development and platelet production |
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532 2632 GBE1 False True Glycogen synthesis;Glycogen storage disease type IV (GBE1) |
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533 2634 GBP2 False True Interferon gamma signaling;Interferon alpha/beta signaling |
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534 2664 GDI1 False True Rho GTPase cycle;RAB GEFs exchange GTP for GDP on RABs |
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535 2665 GDI2 True True Rho GTPase cycle;Neutrophil degranulation;RAB GEFs exchange GTP for GDP on RABs |
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536 2670 GFAP False True Nuclear signaling by ERBB4 |
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537 2673 GFPT1 False True XBP1(S) activates chaperone genes;Defective GFPT1 causes CMSTA1;Synthesis of UDP-N-acetyl-glucosamine |
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538 2706 GJB2 False True Oligomerization of connexins into connexons;Transport of connexins along the secretory pathway;Gap junction assembly;Transport of connexons to the plasma membrane |
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539 2709 GJB5 False True Gap junction assembly |
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540 2717 GLA False True Glycosphingolipid metabolism;Neutrophil degranulation |
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541 2739 GLO1 False True Pyruvate metabolism |
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542 2742 GLRA2 False True Neurotransmitter receptors and postsynaptic signal transmission |
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543 2744 GLS False True Glutamate Neurotransmitter Release Cycle;TP53 Regulates Metabolic Genes;Amino acid synthesis and interconversion (transamination) |
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544 2745 GLRX False True Interconversion of nucleotide di- and triphosphates |
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545 2770 GNAI1 False True PLC beta mediated events;PLC beta mediated events;Adenylate cyclase inhibitory pathway;Adenylate cyclase inhibitory pathway;G-protein activation;ADP signalling through P2Y purinoceptor 12;Adrenaline,noradrenaline inhibits insulin secretion;Adrenaline,noradrenaline inhibits insulin secretion;G alpha (s) signalling events;G alpha (i) signalling events;G alpha (i) signalling events;G alpha (z) signalling events;Regulation of insulin secretion;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding |
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546 2771 GNAI2 False True PLC beta mediated events;PLC beta mediated events;Adenylate cyclase inhibitory pathway;Adenylate cyclase inhibitory pathway;G-protein activation;ADP signalling through P2Y purinoceptor 12;Adrenaline,noradrenaline inhibits insulin secretion;Adrenaline,noradrenaline inhibits insulin secretion;G alpha (s) signalling events;G alpha (i) signalling events;G alpha (i) signalling events;G alpha (z) signalling events;Regulation of insulin secretion;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding |
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547 2773 GNAI3 False True PLC beta mediated events;PLC beta mediated events;Adenylate cyclase inhibitory pathway;Adenylate cyclase inhibitory pathway;G-protein activation;ADP signalling through P2Y purinoceptor 12;G alpha (s) signalling events;G alpha (i) signalling events;G alpha (i) signalling events;G alpha (z) signalling events;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding |
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548 2778 GNAS False True Glucagon signaling in metabolic regulation;PKA activation in glucagon signalling;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Prostacyclin signalling through prostacyclin receptor;Prostacyclin signalling through prostacyclin receptor;G alpha (s) signalling events;G alpha (s) signalling events;G alpha (i) signalling events;G alpha (z) signalling events;Glucagon-type ligand receptors;Vasopressin regulates renal water homeostasis via Aquaporins;Hedgehog 'off' state |
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549 2782 GNB1 False True Activation of G protein gated Potassium channels;Glucagon signaling in metabolic regulation;G-protein activation;Activation of the phototransduction cascade;Activation of the phototransduction cascade;Inactivation, recovery and regulation of the phototransduction cascade;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Olfactory Signaling Pathway;ADP signalling through P2Y purinoceptor 12;G beta:gamma signalling through PI3Kgamma;Prostacyclin signalling through prostacyclin receptor;Prostacyclin signalling through prostacyclin receptor;Adrenaline,noradrenaline inhibits insulin secretion;Adrenaline,noradrenaline inhibits insulin secretion;Ca2+ pathway;Ca2+ pathway;G alpha (q) signalling events;G alpha (12/13) signalling events;G beta:gamma signalling through PLC beta;G alpha (s) signalling events;ADP signalling through P2Y purinoceptor 1;ADP signalling through P2Y purinoceptor 1;G alpha (i) signalling events;G alpha (z) signalling events;Glucagon-type ligand receptors;Thromboxane signalling through TP receptor;Vasopressin regulates renal water homeostasis via Aquaporins;Thrombin signalling through proteinase activated receptors (PARs);Thrombin signalling through proteinase activated receptors (PARs);Presynaptic function of Kainate receptors;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding;G beta:gamma signalling through BTK;G beta:gamma signalling through CDC42;Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
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550 2783 GNB2 False True Activation of G protein gated Potassium channels;Glucagon signaling in metabolic regulation;G-protein activation;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;ADP signalling through P2Y purinoceptor 12;G beta:gamma signalling through PI3Kgamma;Prostacyclin signalling through prostacyclin receptor;Prostacyclin signalling through prostacyclin receptor;Adrenaline,noradrenaline inhibits insulin secretion;Adrenaline,noradrenaline inhibits insulin secretion;Ca2+ pathway;Ca2+ pathway;G alpha (q) signalling events;G alpha (12/13) signalling events;G beta:gamma signalling through PLC beta;G alpha (s) signalling events;ADP signalling through P2Y purinoceptor 1;ADP signalling through P2Y purinoceptor 1;G alpha (i) signalling events;G alpha (z) signalling events;Glucagon-type ligand receptors;Thromboxane signalling through TP receptor;Vasopressin regulates renal water homeostasis via Aquaporins;Thrombin signalling through proteinase activated receptors (PARs);Thrombin signalling through proteinase activated receptors (PARs);Presynaptic function of Kainate receptors;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding;G beta:gamma signalling through BTK;G beta:gamma signalling through CDC42;Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
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551 2794 GNL1 False True NA |
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552 2801 GOLGA2 False True Golgi Cisternae Pericentriolar Stack Reorganization;Golgi Cisternae Pericentriolar Stack Reorganization;COPII-mediated vesicle transport;COPI-mediated anterograde transport;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models |
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553 2803 GOLGA4 False True Retrograde transport at the Trans-Golgi-Network |
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554 2805 GOT1 False True Methionine salvage pathway;Gluconeogenesis;Amino acid synthesis and interconversion (transamination) |
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555 2806 GOT2 False True Degradation of cysteine and homocysteine;Glyoxylate metabolism and glycine degradation;Gluconeogenesis;Amino acid synthesis and interconversion (transamination) |
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556 2810 SFN True True Activation of BAD and translocation to mitochondria ;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Translocation of SLC2A4 (GLUT4) to the plasma membrane;RHO GTPases activate PKNs;TP53 Regulates Metabolic Genes;TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;Regulation of localization of FOXO transcription factors |
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557 2811 GP1BA False True Intrinsic Pathway of Fibrin Clot Formation;GP1b-IX-V activation signalling;Platelet Adhesion to exposed collagen;Platelet Aggregation (Plug Formation);RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function |
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558 2812 GP1BB False True Intrinsic Pathway of Fibrin Clot Formation;GP1b-IX-V activation signalling;Platelet Adhesion to exposed collagen;Platelet Aggregation (Plug Formation) |
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559 2821 GPI False True TP53 Regulates Metabolic Genes;Neutrophil degranulation;Glycolysis;Gluconeogenesis |
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560 2848 GPR25 False True G alpha (s) signalling events |
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561 2861 GPR37 False True Peptide ligand-binding receptors;G alpha (i) signalling events |
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562 2868 GRK4 False True Inactivation, recovery and regulation of the phototransduction cascade |
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563 2870 GRK6 False True G alpha (s) signalling events |
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564 2875 GPT False True Amino acid synthesis and interconversion (transamination) |
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565 2879 GPX4 False True Synthesis of 5-eicosatetraenoic acids;Synthesis of 12-eicosatetraenoic acid derivatives;Synthesis of 15-eicosatetraenoic acid derivatives;Biosynthesis of D-series resolvins;Biosynthesis of E-series 18(S)-resolvins;Biosynthesis of aspirin-triggered D-series resolvins;Biosynthesis of E-series 18(R)-resolvins |
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566 2882 GPX7 False True Detoxification of Reactive Oxygen Species |
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567 2885 GRB2 False True PI3K Cascade;SOS-mediated signalling;SOS-mediated signalling;Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants;SHC1 events in ERBB2 signaling;SHC1 events in ERBB4 signaling;PIP3 activates AKT signaling;Spry regulation of FGF signaling;Signaling by SCF-KIT;Regulation of KIT signaling;Signalling to RAS;Signalling to RAS;GRB2 events in EGFR signaling;GAB1 signalosome;SHC1 events in EGFR signaling;EGFR downregulation;Signaling by cytosolic FGFR1 fusion mutants;Downstream signal transduction;GRB2 events in ERBB2 signaling;GRB2 events in ERBB2 signaling;PI3K events in ERBB2 signaling;Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;Tie2 Signaling;EGFR Transactivation by Gastrin;Constitutive Signaling by Aberrant PI3K in Cancer;DAP12 signaling;SHC-related events triggered by IGF1R;SHC-related events triggered by IGF1R;Role of LAT2/NTAL/LAB on calcium mobilization;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;FCERI mediated Ca+2 mobilization;GRB2:SOS provides linkage to MAPK signaling for Integrins ;NCAM signaling for neurite out-growth;Costimulation by the CD28 family;CD28 dependent Vav1 pathway;Signal regulatory protein family interactions;Interleukin-3, Interleukin-5 and GM-CSF signaling;Constitutive Signaling by EGFRvIII;SHC-mediated cascade:FGFR1;PI-3K cascade:FGFR1;FRS-mediated FGFR1 signaling;PI-3K cascade:FGFR2;SHC-mediated cascade:FGFR2;FRS-mediated FGFR2 signaling;SHC-mediated cascade:FGFR3;FRS-mediated FGFR3 signaling;PI-3K cascade:FGFR3;FRS-mediated FGFR4 signaling;SHC-mediated cascade:FGFR4;PI-3K cascade:FGFR4;Negative regulation of FGFR1 signaling;Negative regulation of FGFR2 signaling;Negative regulation of FGFR3 signaling;Negative regulation of FGFR4 signaling;Signaling by FGFR2 in disease;Signaling by FGFR4 in disease;Signaling by FGFR1 in disease;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs;RAF/MAP kinase cascade;Negative regulation of MET activity;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Signal attenuation;Insulin receptor signalling cascade;Insulin receptor signalling cascade;MET activates RAS signaling;MET activates PI3K/AKT signaling;Signaling by FGFR3 fusions in cancer;Signaling by FGFR3 point mutants in cancer;RET signaling;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;MET activates PTPN11;InlB-mediated entry of Listeria monocytogenes into host cell;InlB-mediated entry of Listeria monocytogenes into host cell;MET activates RAP1 and RAC1;MET receptor recycling;Interleukin-15 signaling;Interleukin-15 signaling;Activated NTRK2 signals through RAS;Erythropoietin activates RAS;Erythropoietin activates RAS;Activated NTRK2 signals through PI3K;Activated NTRK2 signals through FRS2 and FRS3;Activated NTRK2 signals through FRS2 and FRS3;Activated NTRK3 signals through RAS;Interleukin receptor SHC signaling;Regulation of signaling by CBL;Regulation of signaling by CBL;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
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568 2886 GRB7 False True GRB7 events in ERBB2 signaling;Signaling by SCF-KIT;Downstream signal transduction;Tie2 Signaling;RET signaling |
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569 2887 GRB10 False True Signaling by SCF-KIT;IRS activation;Signal attenuation;Insulin receptor signalling cascade;RET signaling |
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570 2904 GRIN2B False True EPHB-mediated forward signaling;EPHB-mediated forward signaling;Unblocking of NMDA receptors, glutamate binding and activation;Unblocking of NMDA receptors, glutamate binding and activation;Ras activation upon Ca2+ influx through NMDA receptor;RAF/MAP kinase cascade;Neurexins and neuroligins;Synaptic adhesion-like molecules;MECP2 regulates neuronal receptors and channels;Activated NTRK2 signals through FYN;Negative regulation of NMDA receptor-mediated neuronal transmission;Long-term potentiation |
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571 2908 NR3C1 False True HSP90 chaperone cycle for steroid hormone receptors (SHR);Nuclear Receptor transcription pathway;Circadian Clock;SUMOylation of intracellular receptors;PTK6 Expression;Regulation of RUNX2 expression and activity;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes |
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572 2912 GRM2 False True G alpha (i) signalling events;Class C/3 (Metabotropic glutamate/pheromone receptors) |
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573 2923 PDIA3 False True ER-Phagosome pathway;ER-Phagosome pathway;Calnexin/calreticulin cycle;Antigen Presentation: Folding, assembly and peptide loading of class I MHC;Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
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574 2931 GSK3A False True AKT phosphorylates targets in the cytosol;XBP1(S) activates chaperone genes;Constitutive Signaling by AKT1 E17K in Cancer |
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575 2934 GSN True True Caspase-mediated cleavage of cytoskeletal proteins;Neutrophil degranulation;Amyloid fiber formation |
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576 2935 GSPT1 False True Eukaryotic Translation Termination;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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577 2936 GSR False True Metabolism of ingested H2SeO4 and H2SeO3 into H2Se;Detoxification of Reactive Oxygen Species;Interconversion of nucleotide di- and triphosphates;TP53 Regulates Metabolic Genes |
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578 2937 GSS True True Glutathione synthesis and recycling;Defective GSS causes Glutathione synthetase deficiency (GSS deficiency) |
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579 2947 GSTM3 False True Glutathione conjugation |
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580 2950 GSTP1 True True Glutathione conjugation;Detoxification of Reactive Oxygen Species;Neutrophil degranulation |
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581 2952 GSTT1 False True Glutathione conjugation |
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582 2954 GSTZ1 False True Glutathione conjugation;Regulation of pyruvate dehydrogenase (PDH) complex;Phenylalanine and tyrosine catabolism |
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583 2956 MSH6 False True Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha);Defective Mismatch Repair Associated With MSH2;Defective Mismatch Repair Associated With MSH6 |
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584 2957 GTF2A1 False True HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;RNA Polymerase II Pre-transcription Events;RNA polymerase II transcribes snRNA genes;RNA polymerase II transcribes snRNA genes;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;Estrogen-dependent gene expression |
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585 2959 GTF2B False True HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;RNA Polymerase II Pre-transcription Events;RNA polymerase II transcribes snRNA genes;RNA polymerase II transcribes snRNA genes;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance |
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586 2963 GTF2F2 False True Formation of RNA Pol II elongation complex ;Formation of the Early Elongation Complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of the HIV-1 Early Elongation Complex;RNA Pol II CTD phosphorylation and interaction with CE during HIV infection;HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;Formation of HIV-1 elongation complex containing HIV-1 Tat;Formation of HIV-1 elongation complex containing HIV-1 Tat;Pausing and recovery of Tat-mediated HIV elongation;Abortive elongation of HIV-1 transcript in the absence of Tat;Tat-mediated HIV elongation arrest and recovery;Tat-mediated elongation of the HIV-1 transcript;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;Viral Messenger RNA Synthesis;RNA Polymerase II Pre-transcription Events;TP53 Regulates Transcription of DNA Repair Genes;FGFR2 alternative splicing;RNA polymerase II transcribes snRNA genes;RNA polymerase II transcribes snRNA genes;mRNA Capping;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;Processing of Capped Intron-Containing Pre-mRNA;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Elongation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Pol II CTD phosphorylation and interaction with CE;Signaling by FGFR2 IIIa TM;Estrogen-dependent gene expression |
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587 2978 NA False True Inactivation, recovery and regulation of the phototransduction cascade |
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588 2983 GUCY1B3 False True Nitric oxide stimulates guanylate cyclase;Smooth Muscle Contraction |
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589 3005 H1F0 False True Activation of DNA fragmentation factor;Formation of Senescence-Associated Heterochromatin Foci (SAHF) |
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590 3006 HIST1H1C False True Activation of DNA fragmentation factor;Formation of Senescence-Associated Heterochromatin Foci (SAHF) |
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591 3007 NA False True Activation of DNA fragmentation factor;Formation of Senescence-Associated Heterochromatin Foci (SAHF) |
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592 3008 HIST1H1E False True Activation of DNA fragmentation factor;Formation of Senescence-Associated Heterochromatin Foci (SAHF) |
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593 3009 HIST1H1B False True Activation of DNA fragmentation factor;Formation of Senescence-Associated Heterochromatin Foci (SAHF) |
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594 3012 NA False True Meiotic synapsis;Packaging Of Telomere Ends;Pre-NOTCH Transcription and Translation;Formation of the beta-catenin:TCF transactivating complex;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;HDACs deacetylate histones;HATs acetylate histones;HATs acetylate histones;RMTs methylate histone arginines;SIRT1 negatively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;NoRC negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;B-WICH complex positively regulates rRNA expression;DNA methylation;Transcriptional regulation by small RNAs;Activation of anterior HOX genes in hindbrain development during early embryogenesis;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;UCH proteinases;Ub-specific processing proteases;Metalloprotease DUBs;Deposition of new CENPA-containing nucleosomes at the centromere;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Estrogen-dependent gene expression;Meiotic recombination;Amyloid fiber formation |
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595 3014 H2AFX False True Meiotic synapsis;Packaging Of Telomere Ends;Pre-NOTCH Transcription and Translation;Formation of the beta-catenin:TCF transactivating complex;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;RMTs methylate histone arginines;SIRT1 negatively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;NoRC negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;B-WICH complex positively regulates rRNA expression;DNA methylation;Transcriptional regulation by small RNAs;Activation of anterior HOX genes in hindbrain development during early embryogenesis;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Processing of DNA double-strand break ends;Deposition of new CENPA-containing nucleosomes at the centromere;G2/M DNA damage checkpoint;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Estrogen-dependent gene expression;Meiotic recombination;Amyloid fiber formation |
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596 3015 H2AFZ False True Meiotic synapsis;Packaging Of Telomere Ends;Pre-NOTCH Transcription and Translation;Formation of the beta-catenin:TCF transactivating complex;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;RMTs methylate histone arginines;SIRT1 negatively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;NoRC negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;B-WICH complex positively regulates rRNA expression;DNA methylation;Transcriptional regulation by small RNAs;Activation of anterior HOX genes in hindbrain development during early embryogenesis;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Deposition of new CENPA-containing nucleosomes at the centromere;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Estrogen-dependent gene expression;Meiotic recombination;Amyloid fiber formation |
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597 3018 HIST1H2BB False True Meiotic synapsis;Packaging Of Telomere Ends;Pre-NOTCH Transcription and Translation;Formation of the beta-catenin:TCF transactivating complex;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;HDACs deacetylate histones;HATs acetylate histones;HATs acetylate histones;SIRT1 negatively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;NoRC negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;B-WICH complex positively regulates rRNA expression;DNA methylation;Transcriptional regulation by small RNAs;Activation of anterior HOX genes in hindbrain development during early embryogenesis;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Ub-specific processing proteases;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Processing of DNA double-strand break ends;Deposition of new CENPA-containing nucleosomes at the centromere;G2/M DNA damage checkpoint;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;E3 ubiquitin ligases ubiquitinate target proteins;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Estrogen-dependent gene expression;Meiotic recombination;Amyloid fiber formation |
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598 3024 HIST1H1A False True Activation of DNA fragmentation factor;Formation of Senescence-Associated Heterochromatin Foci (SAHF) |
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599 3028 HSD17B10 False True tRNA processing in the mitochondrion;tRNA modification in the mitochondrion;Branched-chain amino acid catabolism;rRNA processing in the mitochondrion |
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600 3029 HAGH False True Pyruvate metabolism |
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601 3032 HADHB False True Acyl chain remodeling of CL;Beta oxidation of myristoyl-CoA to lauroyl-CoA;mitochondrial fatty acid beta-oxidation of unsaturated fatty acids;Beta oxidation of palmitoyl-CoA to myristoyl-CoA;Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA;Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA;Beta oxidation of octanoyl-CoA to hexanoyl-CoA;Beta oxidation of hexanoyl-CoA to butanoyl-CoA |
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602 3034 HAL True True Histidine catabolism |
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603 3035 HARS False True Cytosolic tRNA aminoacylation |
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604 3039 HBA1 False True Erythrocytes take up carbon dioxide and release oxygen;Erythrocytes take up oxygen and release carbon dioxide;Scavenging of heme from plasma |
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605 3040 HBA2 False True Erythrocytes take up carbon dioxide and release oxygen;Erythrocytes take up oxygen and release carbon dioxide;Scavenging of heme from plasma |
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606 3043 HBB True True Erythrocytes take up carbon dioxide and release oxygen;Erythrocytes take up oxygen and release carbon dioxide;Scavenging of heme from plasma;Neutrophil degranulation;Factors involved in megakaryocyte development and platelet production |
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607 3054 HCFC1 False True Transcriptional activation of mitochondrial biogenesis;HATs acetylate histones;UCH proteinases |
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608 3055 HCK False True Nef and signal transduction;FCGR activation;Regulation of signaling by CBL;Regulation of signaling by CBL |
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609 3064 HTT False True Regulation of MECP2 expression and activity |
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610 3065 HDAC1 False True Transcription of E2F targets under negative control by DREAM complex;Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1;G0 and Early G1;p75NTR negatively regulates cell cycle via SC1;Formation of the beta-catenin:TCF transactivating complex;NOTCH1 Intracellular Domain Regulates Transcription;Downregulation of SMAD2/3:SMAD4 transcriptional activity;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;HDACs deacetylate histones;Deactivation of the beta-catenin transactivating complex;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;NoRC negatively regulates rRNA expression;SUMOylation of chromatin organization proteins;Repression of WNT target genes;Repression of WNT target genes;Activation of E2F1 target genes at G1/S;Regulation of TP53 Activity through Acetylation;RNA Polymerase I Transcription Initiation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Regulation of PTEN gene transcription;Regulation of PTEN gene transcription;Estrogen-dependent gene expression;Loss of MECP2 binding ability to 5mC-DNA;Regulation of MECP2 expression and activity;MECP2 regulates neuronal receptors and channels;MECP2 regulates transcription of neuronal ligands;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes;Factors involved in megakaryocyte development and platelet production |
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611 3066 HDAC2 False True p75NTR negatively regulates cell cycle via SC1;NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;HDACs deacetylate histones;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;NoRC negatively regulates rRNA expression;SUMOylation of chromatin organization proteins;Regulation of TP53 Activity through Acetylation;RNA Polymerase I Transcription Initiation;Regulation of PTEN gene transcription;Regulation of PTEN gene transcription;Regulation of MECP2 expression and activity;MECP2 regulates neuronal receptors and channels;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes;Factors involved in megakaryocyte development and platelet production |
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612 3068 HDGF False True XBP1(S) activates chaperone genes |
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613 3069 HDLBP False True HDL clearance |
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614 3070 HELLS False True NA |
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615 3074 HEXB False True Glycosphingolipid metabolism;Keratan sulfate degradation;CS/DS degradation;Hyaluronan uptake and degradation;Defective HEXB causes GM2G2;Neutrophil degranulation |
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616 3075 CFH False True Regulation of Complement cascade |
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617 3091 HIF1A False True Regulation of gene expression by Hypoxia-inducible Factor;Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;NOTCH1 Intracellular Domain Regulates Transcription;Circadian Clock;Ub-specific processing proteases;Interleukin-4 and Interleukin-13 signaling;PTK6 Expression;PTK6 promotes HIF1A stabilization;Neddylation |
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618 3092 HIP1 False True Clathrin-mediated endocytosis |
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619 3093 UBE2K False True Synthesis of active ubiquitin: roles of E1 and E2 enzymes;Negative regulators of DDX58/IFIH1 signaling;Antigen processing: Ubiquitination & Proteasome degradation |
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620 3094 HINT1 False True NA |
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621 3096 HIVEP1 False True NA |
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622 3097 NA False True NA |
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623 3099 HK2 False True Glycolysis |
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624 3101 HK3 False True Neutrophil degranulation;Glycolysis |
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625 3115 HLA-DPB1 False True Downstream TCR signaling;Phosphorylation of CD3 and TCR zeta chains;Translocation of ZAP-70 to Immunological synapse;Generation of second messenger molecules;MHC class II antigen presentation;PD-1 signaling;Interferon gamma signaling |
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626 3146 HMGB1 False True Activation of DNA fragmentation factor;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;Regulation of TLR by endogenous ligand;Neutrophil degranulation;Advanced glycosylation endproduct receptor signaling;Advanced glycosylation endproduct receptor signaling;TRAF6 mediated NF-kB activation |
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627 3149 HMGB3 False True NA |
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628 3157 HMGCS1 False True Cholesterol biosynthesis;PPARA activates gene expression;Activation of gene expression by SREBF (SREBP) |
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629 3159 HMGA1 False True Integration of provirus;2-LTR circle formation;Integration of viral DNA into host genomic DNA;Autointegration results in viral DNA circles;APOBEC3G mediated resistance to HIV-1 infection;Vpr-mediated nuclear import of PICs;Formation of Senescence-Associated Heterochromatin Foci (SAHF) |
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630 3162 HMOX1 False True Heme degradation;Interleukin-4 and Interleukin-13 signaling;Iron uptake and transport |
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631 3163 HMOX2 False True Heme degradation;Neutrophil degranulation;Iron uptake and transport |
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632 3176 NA False True Metabolism of ingested SeMet, Sec, MeSec into H2Se;Histidine catabolism |
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633 3178 HNRNPA1 False True FGFR2 alternative splicing;mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA |
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634 3181 HNRNPA2B1 False True mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation |
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635 3182 HNRNPAB False True NA |
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636 3183 HNRNPC False True SUMOylation of RNA binding proteins;mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA |
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637 3184 HNRNPD False True AUF1 (hnRNP D0) binds and destabilizes mRNA;mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA |
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638 3185 HNRNPF False True FGFR2 alternative splicing;mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation |
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639 3187 HNRNPH1 False True FGFR2 alternative splicing;mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA |
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640 3188 HNRNPH2 False True mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA |
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641 3189 HNRNPH3 False True NA |
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642 3190 HNRNPK False True SUMOylation of RNA binding proteins;mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA |
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643 3191 HNRNPL False True mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA |
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644 3192 HNRNPU False True mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA |
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645 3199 HOXA2 False True Activation of anterior HOX genes in hindbrain development during early embryogenesis;Regulation of expression of SLITs and ROBOs |
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646 3240 HP True True Scavenging of heme from plasma;Neutrophil degranulation |
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647 3263 HPX False True Scavenging of heme from plasma |
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648 3280 HES1 False True Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells;NOTCH1 Intracellular Domain Regulates Transcription;NOTCH2 intracellular domain regulates transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;RUNX2 regulates osteoblast differentiation;RUNX3 regulates NOTCH signaling;RUNX3 regulates NOTCH signaling;NOTCH3 Intracellular Domain Regulates Transcription;NOTCH4 Intracellular Domain Regulates Transcription |
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649 3295 HSD17B4 False True Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol;alpha-linolenic acid (ALA) metabolism;Beta-oxidation of pristanoyl-CoA;Beta-oxidation of very long chain fatty acids;Peroxisomal protein import;Peroxisomal protein import;TYSND1 cleaves peroxisomal proteins |
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650 3297 HSF1 False True Regulation of HSF1-mediated heat shock response;HSF1 activation;Attenuation phase;HSF1-dependent transactivation |
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651 3301 DNAJA1 False True HSP90 chaperone cycle for steroid hormone receptors (SHR) |
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652 3303 HSPA1A True True Viral RNP Complexes in the Host Cell Nucleus;Regulation of HSF1-mediated heat shock response;HSP90 chaperone cycle for steroid hormone receptors (SHR);Attenuation phase;HSF1-dependent transactivation;AUF1 (hnRNP D0) binds and destabilizes mRNA;Neutrophil degranulation |
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653 3304 HSPA1B True True Viral RNP Complexes in the Host Cell Nucleus;Regulation of HSF1-mediated heat shock response;HSP90 chaperone cycle for steroid hormone receptors (SHR);Attenuation phase;HSF1-dependent transactivation;AUF1 (hnRNP D0) binds and destabilizes mRNA;Neutrophil degranulation |
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654 3305 HSPA1L False True Regulation of HSF1-mediated heat shock response;HSP90 chaperone cycle for steroid hormone receptors (SHR);Attenuation phase;HSF1-dependent transactivation |
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655 3306 HSPA2 False True Meiotic synapsis;Regulation of HSF1-mediated heat shock response;HSP90 chaperone cycle for steroid hormone receptors (SHR);Attenuation phase |
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656 3308 HSPA4 False True Regulation of HSF1-mediated heat shock response |
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657 3309 HSPA5 True True Platelet degranulation ;Regulation of HSF1-mediated heat shock response;ATF6 (ATF6-alpha) activates chaperones;PERK regulates gene expression;IRE1alpha activates chaperones;ATF6 (ATF6-alpha) activates chaperone genes;Antigen Presentation: Folding, assembly and peptide loading of class I MHC;Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
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658 3310 HSPA6 False True Regulation of HSF1-mediated heat shock response;Neutrophil degranulation |
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659 3311 NA False True NA |
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660 3312 HSPA8 True True Regulation of HSF1-mediated heat shock response;HSP90 chaperone cycle for steroid hormone receptors (SHR);Attenuation phase;HSF1-dependent transactivation;Lysosome Vesicle Biogenesis;Golgi Associated Vesicle Biogenesis;CHL1 interactions;AUF1 (hnRNP D0) binds and destabilizes mRNA;Interleukin-4 and Interleukin-13 signaling;Neutrophil degranulation;mRNA Splicing - Major Pathway;Clathrin-mediated endocytosis;Protein methylation;GABA synthesis, release, reuptake and degradation |
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661 3313 HSPA9 False True Mitochondrial protein import;Regulation of HSF1-mediated heat shock response;Cristae formation;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation |
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662 3315 HSPB1 True True VEGFA-VEGFR2 Pathway;AUF1 (hnRNP D0) binds and destabilizes mRNA;MAPK6/MAPK4 signaling |
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663 3320 HSP90AA1 True True Signaling by ERBB2;Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants;Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation;vRNP Assembly;Regulation of actin dynamics for phagocytic cup formation;eNOS activation;Regulation of PLK1 Activity at G2/M Transition;Scavenging by Class F Receptors;Scavenging by Class F Receptors;HSP90 chaperone cycle for steroid hormone receptors (SHR);HSF1 activation;Attenuation phase;HSF1-dependent transactivation;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Sema3A PAK dependent Axon repulsion;VEGFA-VEGFR2 Pathway;VEGFA-VEGFR2 Pathway;VEGFR2 mediated vascular permeability;Uptake and function of diphtheria toxin;PIWI-interacting RNA (piRNA) biogenesis;Anchoring of the basal body to the plasma membrane;Constitutive Signaling by EGFRvIII;Interleukin-4 and Interleukin-13 signaling;Neutrophil degranulation;The role of GTSE1 in G2/M progression after G2 checkpoint;AURKA Activation by TPX2;Downregulation of ERBB2 signaling;ESR-mediated signaling;Estrogen-dependent gene expression |
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664 3326 HSP90AB1 False True Regulation of actin dynamics for phagocytic cup formation;HSP90 chaperone cycle for steroid hormone receptors (SHR);HSF1 activation;Attenuation phase;HSF1-dependent transactivation;Sema3A PAK dependent Axon repulsion;Uptake and function of diphtheria toxin;Neutrophil degranulation;The NLRP3 inflammasome;The role of GTSE1 in G2/M progression after G2 checkpoint;Aryl hydrocarbon receptor signalling;ESR-mediated signaling;Estrogen-dependent gene expression |
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665 3329 HSPD1 False True Mitochondrial protein import;Mitochondrial protein import;TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation |
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666 3336 HSPE1 False True NA |
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667 3337 DNAJB1 False True Regulation of HSF1-mediated heat shock response;HSP90 chaperone cycle for steroid hormone receptors (SHR);Attenuation phase;HSF1-dependent transactivation;MAPK6/MAPK4 signaling |
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668 3346 NA False True Antimicrobial peptides |
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669 3347 HTN3 False True Antimicrobial peptides |
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670 3376 IARS False True SeMet incorporation into proteins;Cytosolic tRNA aminoacylation |
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671 3398 ID2 False True NA |
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672 3416 IDE True True Ub-specific processing proteases;Peroxisomal protein import;Peroxisomal protein import |
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673 3419 IDH3A False True Citric acid cycle (TCA cycle) |
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674 3433 IFIT2 False True Interferon alpha/beta signaling |
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675 3441 IFNA4 False True Interferon alpha/beta signaling;Regulation of IFNA signaling;Regulation of IFNA signaling;TRAF6 mediated IRF7 activation;Factors involved in megakaryocyte development and platelet production |
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676 3476 IGBP1 False True NA |
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677 3479 IGF1 False True Platelet degranulation ;Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R);IRS-related events triggered by IGF1R;SHC-related events triggered by IGF1R;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Synthesis, secretion, and deacylation of Ghrelin |
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678 3480 IGF1R False True Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R);IRS-related events triggered by IGF1R;SHC-related events triggered by IGF1R |
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679 3481 IGF2 False True Platelet degranulation ;Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R);IRS-related events triggered by IGF1R;SHC-related events triggered by IGF1R;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
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680 3488 IGFBP5 False True Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation |
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681 3491 NA False True Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation |
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682 3500 IGHG1 False True NA |
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683 3501 NA False True NA |
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684 3514 IGKC False True NA |
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685 3516 RBPJ False True Pre-NOTCH Transcription and Translation;Pre-NOTCH Transcription and Translation;Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells;NOTCH1 Intracellular Domain Regulates Transcription;NOTCH1 Intracellular Domain Regulates Transcription;NOTCH2 intracellular domain regulates transcription;NOTCH2 intracellular domain regulates transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Notch-HLH transcription pathway;RUNX3 regulates NOTCH signaling;RUNX3 regulates NOTCH signaling;NOTCH3 Intracellular Domain Regulates Transcription;NOTCH3 Intracellular Domain Regulates Transcription;NOTCH4 Intracellular Domain Regulates Transcription;NOTCH4 Intracellular Domain Regulates Transcription |
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686 3535 IGL False True NA |
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687 3551 IKBKB False True Activation of NF-kappaB in B cells;Activation of NF-kappaB in B cells;ER-Phagosome pathway;NOD1/2 Signaling Pathway;TICAM1, RIP1-mediated IKK complex recruitment ;RIP-mediated NFkB activation via ZBP1;Downstream TCR signaling;p75NTR recruits signalling complexes;NF-kB is activated and signals survival;FCERI mediated NF-kB activation;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;IKBKB deficiency causes SCID;IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR);IkBA variant leads to EDA-ID;CLEC7A (Dectin-1) signaling;MAP3K8 (TPL2)-dependent MAPK1/3 activation;Interleukin-1 signaling;TRAF6 mediated NF-kB activation;NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10;IRAK1 recruits IKK complex;IKK complex recruitment mediated by RIP1;IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation |
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688 3557 NA True False Interleukin-10 signaling;Interleukin-1 signaling |
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689 3575 IL7R False True Interleukin-7 signaling;Interleukin-7 signaling;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis |
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690 3581 IL9R False True Interleukin-9 signaling |
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691 3608 ILF2 False True Neutrophil degranulation |
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692 3609 ILF3 False True NA |
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693 3611 ILK False True Localization of the PINCH-ILK-PARVIN complex to focal adhesions;Cell-extracellular matrix interactions |
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694 3613 IMPA2 False True Synthesis of IP2, IP, and Ins in the cytosol |
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695 3614 IMPDH1 False True Neutrophil degranulation;Purine ribonucleoside monophosphate biosynthesis |
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696 3615 IMPDH2 False True Neutrophil degranulation;Purine ribonucleoside monophosphate biosynthesis |
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697 3621 ING1 False True NA |
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698 3630 INS False True Regulation of gene expression in beta cells;Insulin processing;Insulin processing;Synthesis, secretion, and deacylation of Ghrelin;Regulation of insulin secretion;COPI-mediated anterograde transport;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;IRS activation;Signal attenuation;Insulin receptor signalling cascade;Signaling by Insulin receptor;Insulin receptor recycling;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes;Amyloid fiber formation |
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699 3632 INPP5A False True Synthesis of IP2, IP, and Ins in the cytosol |
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700 3636 INPPL1 False True Synthesis of PIPs at the plasma membrane;Synthesis of IP3 and IP4 in the cytosol;Interleukin receptor SHC signaling |
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701 3645 INSRR False True NA |
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702 3646 EIF3E False True L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit |
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703 3656 IRAK2 False True MyD88:MAL(TIRAP) cascade initiated on plasma membrane;NOD1/2 Signaling Pathway;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;activated TAK1 mediates p38 MAPK activation;JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1;Interleukin-1 signaling;IRAK2 mediated activation of TAK1 complex;TRAF6-mediated induction of TAK1 complex within TLR4 complex;TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation;MyD88 dependent cascade initiated on endosome;IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation;MyD88 cascade initiated on plasma membrane |
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704 3658 IREB2 False True Iron uptake and transport |
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705 3660 IRF2 False True Interferon gamma signaling;Interferon alpha/beta signaling;Factors involved in megakaryocyte development and platelet production |
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706 3661 IRF3 False True ISG15 antiviral mechanism;IRF3 mediated activation of type 1 IFN;IRF3 mediated activation of type 1 IFN;LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production;Regulation of innate immune responses to cytosolic DNA;IRF3-mediated induction of type I IFN;Interferon gamma signaling;TICAM1-dependent activation of IRF3/IRF7;Interferon alpha/beta signaling;TRAF3-dependent IRF activation pathway;TRAF6 mediated IRF7 activation;Negative regulators of DDX58/IFIH1 signaling;Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon |
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707 3667 IRS1 False True PI3K Cascade;IRS-mediated signalling;SOS-mediated signalling;SOS-mediated signalling;PIP3 activates AKT signaling;Interleukin-7 signaling;PI3K/AKT activation;PI3K/AKT activation;Constitutive Signaling by Aberrant PI3K in Cancer;IRS-related events triggered by IGF1R;Signaling by Leptin;RAF/MAP kinase cascade;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;IRS activation;Signal attenuation;Activated NTRK3 signals through PI3K;Growth hormone receptor signaling |
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708 3673 ITGA2 False True Integrin cell surface interactions;Integrin cell surface interactions;Laminin interactions;Laminin interactions;Syndecan interactions;ECM proteoglycans;CHL1 interactions;Platelet Adhesion to exposed collagen;MET activates PTK2 signaling |
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709 3684 ITGAM False True Toll Like Receptor 4 (TLR4) Cascade;Cell surface interactions at the vascular wall;Integrin cell surface interactions;Interleukin-4 and Interleukin-13 signaling;Neutrophil degranulation |
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710 3685 ITGAV False True Cross-presentation of particulate exogenous antigens (phagosomes);Elastic fibre formation;PECAM1 interactions;Molecules associated with elastic fibres;Integrin cell surface interactions;Integrin cell surface interactions;Laminin interactions;Syndecan interactions;Syndecan interactions;ECM proteoglycans;VEGFA-VEGFR2 Pathway;Signal transduction by L1;Neutrophil degranulation |
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711 3688 ITGB1 False True Elastic fibre formation;Fibronectin matrix formation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Cell surface interactions at the vascular wall;Basigin interactions;Molecules associated with elastic fibres;Integrin cell surface interactions;Integrin cell surface interactions;Laminin interactions;Laminin interactions;Syndecan interactions;ECM proteoglycans;Other semaphorin interactions;Signal transduction by L1;Localization of the PINCH-ILK-PARVIN complex to focal adhesions;CHL1 interactions;RHO GTPases Activate Formins;Interleukin-4 and Interleukin-13 signaling;Platelet Adhesion to exposed collagen;MET activates PTK2 signaling;MET interacts with TNS proteins |
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712 3690 ITGB3 False True Platelet degranulation ;Elastic fibre formation;PECAM1 interactions;Molecules associated with elastic fibres;Integrin cell surface interactions;Integrin cell surface interactions;Syndecan interactions;Syndecan interactions;ECM proteoglycans;Integrin alphaIIb beta3 signaling;GRB2:SOS provides linkage to MAPK signaling for Integrins ;p130Cas linkage to MAPK signaling for integrins;VEGFA-VEGFR2 Pathway;Signal transduction by L1;MAP2K and MAPK activation;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF |
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713 3692 EIF6 False True NA |
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714 3693 ITGB5 False True Cross-presentation of particulate exogenous antigens (phagosomes);Molecules associated with elastic fibres;Integrin cell surface interactions;Integrin cell surface interactions;Syndecan interactions;Syndecan interactions;ECM proteoglycans;Smooth Muscle Contraction |
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715 3694 ITGB6 False True Elastic fibre formation;Molecules associated with elastic fibres;Integrin cell surface interactions;ECM proteoglycans |
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716 3697 NA False True NA |
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717 3698 ITIH2 False True Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation |
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718 3702 ITK False True Generation of second messenger molecules;FCERI mediated Ca+2 mobilization;FCERI mediated Ca+2 mobilization |
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719 3704 ITPA False True Purine catabolism |
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720 3709 NA False True PLC beta mediated events;Effects of PIP2 hydrolysis;Elevation of cytosolic Ca2+ levels;DAG and IP3 signaling;Role of phospholipids in phagocytosis;FCERI mediated Ca+2 mobilization;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Ca2+ pathway;Regulation of insulin secretion;VEGFR2 mediated cell proliferation;Ion homeostasis;Ion homeostasis;CLEC7A (Dectin-1) induces NFAT activation;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
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721 3710 ITPR3 False True PLC beta mediated events;Effects of PIP2 hydrolysis;Elevation of cytosolic Ca2+ levels;DAG and IP3 signaling;Role of phospholipids in phagocytosis;FCERI mediated Ca+2 mobilization;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Ca2+ pathway;Regulation of insulin secretion;VEGFR2 mediated cell proliferation;Ion homeostasis;Ion homeostasis;CLEC7A (Dectin-1) induces NFAT activation;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
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722 3713 IVL False True Formation of the cornified envelope |
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723 3716 JAK1 False True Interleukin-6 signaling;Interleukin-6 signaling;MAPK3 (ERK1) activation;MAPK1 (ERK2) activation;ISG15 antiviral mechanism;Interleukin-7 signaling;Interleukin-7 signaling;Other interleukin signaling;RAF/MAP kinase cascade;Interleukin-10 signaling;Interleukin-4 and Interleukin-13 signaling;IL-6-type cytokine receptor ligand interactions;Interferon gamma signaling;Regulation of IFNG signaling;Regulation of IFNG signaling;Interleukin-20 family signaling;Interleukin-15 signaling;Interleukin-15 signaling;Interleukin-35 Signalling;Interleukin-9 signaling;Interleukin-2 signaling;Interleukin-12 signaling;Interleukin-12 signaling;Interleukin-27 signaling;Interleukin-27 signaling;Interleukin-21 signaling;Interferon alpha/beta signaling;Interleukin receptor SHC signaling;Regulation of IFNA signaling;Regulation of IFNA signaling |
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724 3717 JAK2 False True Interleukin-6 signaling;Interleukin-6 signaling;MAPK3 (ERK1) activation;MAPK1 (ERK2) activation;Prolactin receptor signaling;Prolactin receptor signaling;Signaling by SCF-KIT;Signaling by Leptin;RMTs methylate histone arginines;Interleukin-3, Interleukin-5 and GM-CSF signaling;Interleukin-3, Interleukin-5 and GM-CSF signaling;RAF activation;RAF/MAP kinase cascade;Interleukin-4 and Interleukin-13 signaling;IL-6-type cytokine receptor ligand interactions;Signaling by moderate kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF;Cyclin D associated events in G1;Interferon gamma signaling;Regulation of IFNG signaling;Regulation of IFNG signaling;Interleukin-20 family signaling;Interleukin-35 Signalling;Signaling by Erythropoietin;Interleukin-12 signaling;Interleukin-12 signaling;Interleukin-23 signaling;Interleukin-23 signaling;Interleukin-27 signaling;Interleukin-27 signaling;Erythropoietin activates Phosphoinositide-3-kinase (PI3K);Erythropoietin activates Phosphoinositide-3-kinase (PI3K);Erythropoietin activates Phospholipase C gamma (PLCG);Erythropoietin activates STAT5;Erythropoietin activates RAS;Erythropoietin activates RAS;Interleukin receptor SHC signaling;Growth hormone receptor signaling;Growth hormone receptor signaling;Factors involved in megakaryocyte development and platelet production |
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725 3720 JARID2 False True PRC2 methylates histones and DNA |
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726 3728 JUP True True Adherens junctions interactions;VEGFR2 mediated vascular permeability;Neutrophil degranulation;Keratinization;Formation of the cornified envelope |
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727 3735 KARS False True SeMet incorporation into proteins;Cytosolic tRNA aminoacylation;Mitochondrial tRNA aminoacylation |
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728 3741 KCNA5 False True Voltage gated Potassium channels |
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729 3742 KCNA6 False True Voltage gated Potassium channels |
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730 3755 KCNG1 False True Voltage gated Potassium channels |
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731 3757 KCNH2 False True Voltage gated Potassium channels;Phase 3 - rapid repolarisation |
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732 3767 KCNJ11 False True ATP sensitive Potassium channels;ABC-family proteins mediated transport;Regulation of insulin secretion;Ion homeostasis;Defective ABCC8 can cause hypoglycemias and hyperglycemias |
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733 3775 KCNK1 False True Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK);Phase 4 - resting membrane potential |
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734 3778 KCNMA1 False True Ca2+ activated K+ channels;cGMP effects |
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735 3790 KCNS3 False True Voltage gated Potassium channels;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion |
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736 3799 KIF5B False True MHC class II antigen presentation;Insulin processing;RHO GTPases activate KTN1;COPI-dependent Golgi-to-ER retrograde traffic;Kinesins |
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737 3801 KIFC3 False True Association of TriC/CCT with target proteins during biosynthesis |
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738 3816 KLK1 True True Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
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739 3827 KNG1 False True Platelet degranulation ;Intrinsic Pathway of Fibrin Clot Formation;Peptide ligand-binding receptors;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);G alpha (q) signalling events;G alpha (i) signalling events;Post-translational protein phosphorylation |
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740 3831 KLC1 False True MHC class II antigen presentation;RHO GTPases activate KTN1;COPI-dependent Golgi-to-ER retrograde traffic;Kinesins |
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741 3832 KIF11 False True MHC class II antigen presentation;COPI-dependent Golgi-to-ER retrograde traffic;Kinesins |
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742 3836 KPNA1 False True ISG15 antiviral mechanism;Integration of provirus;Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Vpr-mediated nuclear import of PICs;Activation of DNA fragmentation factor |
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743 3837 KPNB1 False True ISG15 antiviral mechanism;Regulation of cholesterol biosynthesis by SREBP (SREBF);Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Nuclear import of Rev protein;Nuclear import of Rev protein;Activation of DNA fragmentation factor;Neutrophil degranulation |
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744 3838 KPNA2 False True CaMK IV-mediated phosphorylation of CREB;ISG15 antiviral mechanism;NS1 Mediated Effects on Host Pathways;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;Sensing of DNA Double Strand Breaks;Estrogen-dependent gene expression |
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745 3839 KPNA3 False True ISG15 antiviral mechanism;NS1 Mediated Effects on Host Pathways |
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746 3840 KPNA4 False True ISG15 antiviral mechanism;NS1 Mediated Effects on Host Pathways |
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747 3848 KRT1 True True Neutrophil degranulation;Keratinization;Formation of the cornified envelope |
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748 3849 KRT2 True True Keratinization;Formation of the cornified envelope |
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749 3852 KRT5 False True Type I hemidesmosome assembly;Keratinization;Formation of the cornified envelope |
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750 3853 KRT6A True True Keratinization;Formation of the cornified envelope |
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751 3854 KRT6B True True Keratinization;Formation of the cornified envelope |
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752 3856 KRT8 False True Keratinization;Formation of the cornified envelope |
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753 3857 KRT9 False True Keratinization;Formation of the cornified envelope |
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754 3858 KRT10 True True Keratinization;Formation of the cornified envelope |
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755 3860 KRT13 True True Keratinization;Formation of the cornified envelope |
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756 3861 KRT14 False True Type I hemidesmosome assembly;Keratinization;Formation of the cornified envelope |
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757 3866 KRT15 True True Keratinization;Formation of the cornified envelope |
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758 3868 NA True False Keratinization;Formation of the cornified envelope |
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759 3872 KRT17 True True Keratinization;Formation of the cornified envelope |
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760 3875 KRT18 False True Keratinization;Formation of the cornified envelope |
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761 3880 KRT19 False True Keratinization;Formation of the cornified envelope |
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762 3881 KRT31 False True Keratinization;Formation of the cornified envelope |
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763 3884 KRT33B False True Keratinization;Formation of the cornified envelope |
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764 3887 KRT81 False True Keratinization;Formation of the cornified envelope |
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765 3892 KRT86 False True Keratinization;Formation of the cornified envelope |
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766 3895 KTN1 False True Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);RHO GTPases activate KTN1;Post-translational protein phosphorylation |
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767 3898 LAD1 False True NA |
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768 3912 LAMB1 False True Degradation of the extracellular matrix;Laminin interactions;Laminin interactions;Non-integrin membrane-ECM interactions;ECM proteoglycans;L1CAM interactions;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);MET activates PTK2 signaling;Post-translational protein phosphorylation |
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769 3916 LAMP1 True True Neutrophil degranulation |
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770 3920 LAMP2 True True Platelet degranulation ;Neutrophil degranulation |
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771 3921 RPSA True True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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772 3925 STMN1 False True NA |
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773 3929 LBP False True Toll Like Receptor 4 (TLR4) Cascade;Transfer of LPS from LBP carrier to CD14;Regulation of TLR by endogenous ligand;Interleukin-4 and Interleukin-13 signaling |
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774 3930 LBR False True Cholesterol biosynthesis;Regulation of MECP2 expression and activity |
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775 3932 LCK False True GPVI-mediated activation cascade;PIP3 activates AKT signaling;Signaling by SCF-KIT;Signaling by SCF-KIT;Regulation of KIT signaling;Nef and signal transduction;Nef Mediated CD4 Down-regulation;Downstream TCR signaling;Phosphorylation of CD3 and TCR zeta chains;Translocation of ZAP-70 to Immunological synapse;Generation of second messenger molecules;PECAM1 interactions;Constitutive Signaling by Aberrant PI3K in Cancer;DAP12 signaling;DAP12 signaling;CD28 co-stimulation;CD28 dependent PI3K/Akt signaling;CD28 dependent Vav1 pathway;CTLA4 inhibitory signaling;PD-1 signaling;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Interleukin-2 signaling |
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776 3933 LCN1 True True Transport of fatty acids |
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777 3934 LCN2 True True Interleukin-4 and Interleukin-13 signaling;Neutrophil degranulation;Metal sequestration by antimicrobial proteins;Iron uptake and transport;Iron uptake and transport |
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778 3937 LCP2 False True GPVI-mediated activation cascade;Generation of second messenger molecules;Generation of second messenger molecules;DAP12 signaling;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;FCERI mediated Ca+2 mobilization |
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779 3939 LDHA True True Pyruvate metabolism |
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780 3945 LDHB False True Pyruvate metabolism |
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781 3948 LDHC False True Pyruvate metabolism |
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782 3949 LDLR False True Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Chylomicron clearance;Chylomicron clearance;LDL clearance;Retinoid metabolism and transport |
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783 3956 LGALS1 False True Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation |
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784 3958 LGALS3 False True Neutrophil degranulation;Advanced glycosylation endproduct receptor signaling;RUNX1 regulates transcription of genes involved in differentiation of myeloid cells;RUNX2 regulates genes involved in differentiation of myeloid cells |
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785 3959 LGALS3BP False True Platelet degranulation |
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786 3963 LGALS7 True True NA |
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787 3978 LIG1 False True POLB-Dependent Long Patch Base Excision Repair;Early Phase of HIV Life Cycle;Processive synthesis on the C-strand of the telomere;Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha);Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta);PCNA-Dependent Long Patch Base Excision Repair;Gap-filling DNA repair synthesis and ligation in GG-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Processive synthesis on the lagging strand |
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788 3983 ABLIM1 False True DCC mediated attractive signaling |
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789 3984 LIMK1 False True Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;EPHB-mediated forward signaling;Sema3A PAK dependent Axon repulsion;Sema3A PAK dependent Axon repulsion;Sema4D induced cell migration and growth-cone collapse;RHO GTPases Activate ROCKs;RHO GTPases activate PAKs |
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790 3985 LIMK2 False True EPHB-mediated forward signaling;Sema4D induced cell migration and growth-cone collapse;RHO GTPases Activate ROCKs |
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791 3996 LLGL1 False True NA |
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792 3998 LMAN1 False True COPII-mediated vesicle transport;Cargo concentration in the ER;Transport to the Golgi and subsequent modification |
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793 4000 LMNA True True Meiotic synapsis;Clearance of Nuclear Envelope Membranes from Chromatin;Initiation of Nuclear Envelope Reformation;Breakdown of the nuclear lamina;XBP1(S) activates chaperone genes;Depolymerisation of the Nuclear Lamina;Signaling by BRAF and RAF fusions;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models |
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794 4001 LMNB1 False True Meiotic synapsis;Formation of Senescence-Associated Heterochromatin Foci (SAHF);Clearance of Nuclear Envelope Membranes from Chromatin;Initiation of Nuclear Envelope Reformation;Breakdown of the nuclear lamina;Depolymerisation of the Nuclear Lamina;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation |
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795 4005 LMO2 False True RUNX1 regulates transcription of genes involved in differentiation of HSCs |
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796 4008 LMO7 False True Neddylation;Antigen processing: Ubiquitination & Proteasome degradation |
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797 4014 LOR False True Formation of the cornified envelope |
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798 4026 LPP False True NA |
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799 4033 NA False True Neutrophil degranulation |
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800 4041 LRP5 False True TCF dependent signaling in response to WNT;Negative regulation of TCF-dependent signaling by WNT ligand antagonists;Disassembly of the destruction complex and recruitment of AXIN to the membrane;Disassembly of the destruction complex and recruitment of AXIN to the membrane;Regulation of FZD by ubiquitination;Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling;RNF mutants show enhanced WNT signaling and proliferation |
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801 4047 LSS False True Cholesterol biosynthesis;Activation of gene expression by SREBF (SREBP) |
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802 4048 LTA4H False True Synthesis of Leukotrienes (LT) and Eoxins (EX);Neutrophil degranulation;Biosynthesis of D-series resolvins;Biosynthesis of protectins;Biosynthesis of E-series 18(S)-resolvins;Biosynthesis of aspirin-triggered D-series resolvins;Biosynthesis of E-series 18(R)-resolvins |
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803 4057 LTF True True Mtb iron assimilation by chelation;Neutrophil degranulation;Metal sequestration by antimicrobial proteins;Antimicrobial peptides;Amyloid fiber formation |
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804 4067 LYN False True GPVI-mediated activation cascade;Signaling by SCF-KIT;Signaling by SCF-KIT;Regulation of KIT signaling;Cell surface interactions at the vascular wall;FCGR activation;PECAM1 interactions;Fc epsilon receptor (FCERI) signaling;Fc epsilon receptor (FCERI) signaling;EPH-Ephrin signaling;Role of LAT2/NTAL/LAB on calcium mobilization;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;FCERI mediated Ca+2 mobilization;FCERI mediated NF-kB activation;CD28 co-stimulation;CTLA4 inhibitory signaling;EPHB-mediated forward signaling;EPHB-mediated forward signaling;EPHA-mediated growth cone collapse;EPHA-mediated growth cone collapse;EPH-ephrin mediated repulsion of cells;Dectin-2 family;CD209 (DC-SIGN) signaling;CD22 mediated BCR regulation;Cyclin D associated events in G1;Platelet Adhesion to exposed collagen;Signaling by Erythropoietin;Erythropoietin activates Phosphoinositide-3-kinase (PI3K);Erythropoietin activates Phosphoinositide-3-kinase (PI3K);Erythropoietin activates Phospholipase C gamma (PLCG);Erythropoietin activates STAT5;Erythropoietin activates RAS;Erythropoietin activates RAS;Regulation of signaling by CBL;Regulation of signaling by CBL;Growth hormone receptor signaling;Growth hormone receptor signaling;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
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805 4069 NA True False Neutrophil degranulation;Antimicrobial peptides;Amyloid fiber formation |
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806 4071 TM4SF1 False True NA |
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807 4074 M6PR False True Lysosome Vesicle Biogenesis;Retrograde transport at the Trans-Golgi-Network;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis |
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808 4082 MARCKS False True Acetylcholine regulates insulin secretion |
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809 4086 SMAD1 False True Signaling by BMP;Ub-specific processing proteases;RUNX2 regulates bone development |
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810 4088 SMAD3 False True Signaling by NODAL;Signaling by NODAL;Signaling by Activin;Downregulation of TGF-beta receptor signaling;TGF-beta receptor signaling activates SMADs;Downregulation of SMAD2/3:SMAD4 transcriptional activity;Downregulation of SMAD2/3:SMAD4 transcriptional activity;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;SMAD2/3 Phosphorylation Motif Mutants in Cancer;SMAD4 MH2 Domain Mutants in Cancer;SMAD2/3 MH2 Domain Mutants in Cancer;TGFBR1 KD Mutants in Cancer;Ub-specific processing proteases;RUNX3 regulates CDKN1A transcription;RUNX3 regulates BCL2L11 (BIM) transcription;Interleukin-37 signaling;NOTCH4 Intracellular Domain Regulates Transcription;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes;FOXO-mediated transcription of cell cycle genes;FOXO-mediated transcription of cell cycle genes |
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811 4089 SMAD4 False True Signaling by NODAL;Signaling by Activin;Signaling by BMP;TGF-beta receptor signaling activates SMADs;Downregulation of SMAD2/3:SMAD4 transcriptional activity;Downregulation of SMAD2/3:SMAD4 transcriptional activity;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;SMAD4 MH2 Domain Mutants in Cancer;SMAD2/3 MH2 Domain Mutants in Cancer;Transcriptional regulation of pluripotent stem cells;Ub-specific processing proteases;RUNX2 regulates bone development;RUNX3 regulates CDKN1A transcription;RUNX3 regulates BCL2L11 (BIM) transcription;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes;FOXO-mediated transcription of cell cycle genes;FOXO-mediated transcription of cell cycle genes |
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812 4097 MAFG False True Factors involved in megakaryocyte development and platelet production;Factors involved in megakaryocyte development and platelet production |
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813 4100 MAGEA1 False True NA |
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814 4113 MAGEB2 False True NA |
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815 4115 MAGEB4 False True NA |
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816 4118 MAL False True NA |
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817 4131 MAP1B False True NA |
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818 4133 MAP2 False True NA |
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819 4134 MAP4 False True NA |
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820 4137 MAPT False True Caspase-mediated cleavage of cytoskeletal proteins;Activation of AMPK downstream of NMDARs |
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821 4139 MARK1 False True NA |
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822 4140 MARK3 False True RAF activation;MAP2K and MAPK activation;Negative regulation of MAPK pathway;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF |
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823 4144 MAT2A False True Methylation |
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824 4145 MATK False True Downregulation of ERBB2 signaling |
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825 4149 MAX False True Transcription of E2F targets under negative control by DREAM complex;Cyclin E associated events during G1/S transition ;Cyclin A:Cdk2-associated events at S phase entry;Transcriptional Regulation by E2F6 |
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826 4153 MBL2 False True Lectin pathway of complement activation;Initial triggering of complement |
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827 4168 MCF2 False True Axonal growth inhibition (RHOA activation);NRAGE signals death through JNK;Rho GTPase cycle;G alpha (12/13) signalling events |
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828 4170 MCL1 False True Interleukin-4 and Interleukin-13 signaling |
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829 4171 MCM2 False True Activation of ATR in response to replication stress;Unwinding of DNA;Assembly of the pre-replicative complex;Orc1 removal from chromatin;Activation of the pre-replicative complex;Switching of origins to a post-replicative state |
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830 4172 MCM3 False True Activation of ATR in response to replication stress;Unwinding of DNA;Assembly of the pre-replicative complex;Orc1 removal from chromatin;Activation of the pre-replicative complex;Switching of origins to a post-replicative state |
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831 4173 MCM4 False True Activation of ATR in response to replication stress;Unwinding of DNA;Assembly of the pre-replicative complex;Orc1 removal from chromatin;Activation of the pre-replicative complex;Switching of origins to a post-replicative state |
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832 4174 MCM5 False True Activation of ATR in response to replication stress;Unwinding of DNA;Assembly of the pre-replicative complex;Orc1 removal from chromatin;Activation of the pre-replicative complex;Switching of origins to a post-replicative state |
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833 4175 MCM6 False True Activation of ATR in response to replication stress;Unwinding of DNA;Assembly of the pre-replicative complex;Orc1 removal from chromatin;Activation of the pre-replicative complex;Switching of origins to a post-replicative state |
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834 4176 MCM7 False True Activation of ATR in response to replication stress;Unwinding of DNA;Assembly of the pre-replicative complex;Orc1 removal from chromatin;Activation of the pre-replicative complex;Switching of origins to a post-replicative state |
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835 4190 MDH1 False True Gluconeogenesis |
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836 4191 MDH2 True True Gluconeogenesis;Citric acid cycle (TCA cycle) |
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837 4193 MDM2 False True AKT phosphorylates targets in the cytosol;Oxidative Stress Induced Senescence;Oncogene Induced Senescence;SUMOylation of transcription factors;SUMOylation of ubiquitinylation proteins;Trafficking of AMPA receptors;Constitutive Signaling by AKT1 E17K in Cancer;Ub-specific processing proteases;Regulation of TP53 Activity through Phosphorylation;Regulation of TP53 Degradation;Regulation of TP53 Activity through Methylation;Stabilization of p53;Regulation of RUNX3 expression and activity |
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838 4194 MDM4 False True Oxidative Stress Induced Senescence;Oncogene Induced Senescence;Ub-specific processing proteases;Regulation of TP53 Activity through Phosphorylation;Regulation of TP53 Degradation;Regulation of TP53 Activity through Methylation;Stabilization of p53 |
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839 4199 ME1 False True PPARA activates gene expression;Pyruvate metabolism |
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840 4204 MECP2 False True Transcriptional Regulation by MECP2;Transcriptional Regulation by MECP2;Loss of MECP2 binding ability to 5hmC-DNA;Loss of phosphorylation of MECP2 at T308;Loss of MECP2 binding ability to the NCoR/SMRT complex;Loss of MECP2 binding ability to 5mC-DNA;Regulation of MECP2 expression and activity;Regulation of MECP2 expression and activity;MECP2 regulates neuronal receptors and channels;MECP2 regulates neuronal receptors and channels;MECP2 regulates transcription of neuronal ligands;MECP2 regulates transcription factors;MECP2 regulates transcription of genes involved in GABA signaling |
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841 4205 MEF2A False True ERK/MAPK targets;CDO in myogenesis |
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842 4212 MEIS2 False True NA |
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843 4214 MAP3K1 False True MyD88:MAL(TIRAP) cascade initiated on plasma membrane;FCERI mediated MAPK activation;FCERI mediated MAPK activation;TRAF6 mediated NF-kB activation;TRAF6 mediated NF-kB activation;TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation;MyD88 cascade initiated on plasma membrane |
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844 4215 MAP3K3 False True Interleukin-1 signaling |
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845 4217 MAP3K5 False True Oxidative Stress Induced Senescence;Oxidative Stress Induced Senescence |
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846 4218 RAB8A False True Translocation of SLC2A4 (GLUT4) to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Anchoring of the basal body to the plasma membrane;VxPx cargo-targeting to cilium;TBC/RABGAPs;RAB geranylgeranylation;RAB GEFs exchange GTP for GDP on RABs |
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847 4222 MEOX1 False True NA |
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848 4223 MEOX2 False True NA |
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849 4233 MET False True PIP3 activates AKT signaling;Constitutive Signaling by Aberrant PI3K in Cancer;Sema4D mediated inhibition of cell attachment and migration;RAF/MAP kinase cascade;MET Receptor Activation;Negative regulation of MET activity;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;MET activates RAS signaling;MET activates PI3K/AKT signaling;MET activates PTPN11;MET activates PTK2 signaling;InlB-mediated entry of Listeria monocytogenes into host cell;InlB-mediated entry of Listeria monocytogenes into host cell;MET interacts with TNS proteins;MET activates RAP1 and RAC1;MET receptor recycling;MET activates STAT3;MECP2 regulates neuronal receptors and channels |
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850 4234 METTL1 False True tRNA modification in the nucleus and cytosol |
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851 4236 MFAP1 False True Molecules associated with elastic fibres |
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852 4253 CTAGE5 False True Cargo concentration in the ER |
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853 4259 MGST3 False True Glutathione conjugation;Aflatoxin activation and detoxification |
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854 4282 MIF False True Cell surface interactions at the vascular wall;Neutrophil degranulation;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation |
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855 4284 MIP False True Passive transport by Aquaporins |
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856 4287 ATXN3 False True Josephin domain DUBs;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes |
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857 4288 MKI67 False True NA |
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858 4289 MKLN1 False True NA |
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859 4292 MLH1 False True Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha);Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta);Defective Mismatch Repair Associated With MLH1;Defective Mismatch Repair Associated With PMS2;TP53 Regulates Transcription of DNA Repair Genes;Meiotic recombination |
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860 4293 MAP3K9 False True NA |
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861 4301 MLLT4 False True Adherens junctions interactions;Adherens junctions interactions |
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862 4303 FOXO4 False True AKT phosphorylates targets in the nucleus;Constitutive Signaling by AKT1 E17K in Cancer;Ub-specific processing proteases;Regulation of localization of FOXO transcription factors;FOXO-mediated transcription of cell death genes;FOXO-mediated transcription of cell death genes;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes;Regulation of FOXO transcriptional activity by acetylation;FOXO-mediated transcription of cell cycle genes;FOXO-mediated transcription of cell cycle genes |
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863 4306 NR3C2 False True HSP90 chaperone cycle for steroid hormone receptors (SHR);Nuclear Receptor transcription pathway;SUMOylation of intracellular receptors |
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864 4311 MME False True Metabolism of Angiotensinogen to Angiotensins;Neutrophil degranulation |
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865 4313 MMP2 False True Collagen degradation;Collagen degradation;Degradation of the extracellular matrix;Degradation of the extracellular matrix;Activation of Matrix Metalloproteinases;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);EPH-ephrin mediated repulsion of cells;Interleukin-4 and Interleukin-13 signaling |
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866 4329 ALDH6A1 False True Branched-chain amino acid catabolism |
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867 4342 MOS False True NA |
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868 4351 MPI False True Defective MPI causes MPI-CDG (CDG-1b);Synthesis of GDP-mannose |
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869 4361 MRE11A False True Cytosolic sensors of pathogen-associated DNA ;DNA Damage/Telomere Stress Induced Senescence;IRF3-mediated induction of type I IFN;HDR through Single Strand Annealing (SSA);HDR through MMEJ (alt-NHEJ);HDR through Homologous Recombination (HRR);Sensing of DNA Double Strand Breaks;Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA);Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Resolution of D-loop Structures through Holliday Junction Intermediates;Nonhomologous End-Joining (NHEJ);Homologous DNA Pairing and Strand Exchange;Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;Regulation of TP53 Activity through Phosphorylation;G2/M DNA damage checkpoint;Meiotic recombination |
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870 4430 NA False True NA |
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871 4478 MSN False True Recycling pathway of L1;Recycling pathway of L1;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation |
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872 4481 MSR1 False True Scavenging by Class A Receptors;Scavenging by Class A Receptors |
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873 4496 NA False True Metallothioneins bind metals |
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874 4507 MTAP False True Methionine salvage pathway;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation |
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875 4513 COX2 False True TP53 Regulates Metabolic Genes;Respiratory electron transport |
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876 4522 MTHFD1 False True Metabolism of folate and pterines |
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877 4528 NA False True Mitochondrial translation initiation |
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878 4580 MTX1 False True Mitochondrial protein import;Cristae formation |
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879 4586 MUC5AC False True Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC);Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS);Defective GALNT12 causes colorectal cancer 1 (CRCS1);Dectin-2 family;O-linked glycosylation of mucins;Termination of O-glycan biosynthesis |
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880 4589 NA True False Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC);Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS);Defective GALNT12 causes colorectal cancer 1 (CRCS1);Dectin-2 family;O-linked glycosylation of mucins;Termination of O-glycan biosynthesis |
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881 4591 TRIM37 False True Antigen processing: Ubiquitination & Proteasome degradation |
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882 4593 MUSK False True ECM proteoglycans |
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883 4595 MUTYH False True Recognition and association of DNA glycosylase with site containing an affected purine;Cleavage of the damaged purine;Displacement of DNA glycosylase by APEX1;Defective MUTYH substrate binding;Defective MUTYH substrate processing |
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884 4597 MVD False True Cholesterol biosynthesis;Activation of gene expression by SREBF (SREBP);Synthesis of Dolichyl-phosphate |
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885 4598 MVK False True Cholesterol biosynthesis;Activation of gene expression by SREBF (SREBP) |
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886 4602 MYB False True RUNX1 regulates transcription of genes involved in differentiation of HSCs;Estrogen-dependent gene expression;Factors involved in megakaryocyte development and platelet production |
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887 4607 MYBPC3 False True Striated Muscle Contraction |
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888 4609 MYC False True Transcription of E2F targets under negative control by DREAM complex;NOTCH1 Intracellular Domain Regulates Transcription;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Binding of TCF/LEF:CTNNB1 to target gene promoters;MAPK6/MAPK4 signaling;Ub-specific processing proteases;Interleukin-4 and Interleukin-13 signaling;Cyclin E associated events during G1/S transition ;Cyclin A:Cdk2-associated events at S phase entry;TFAP2 (AP-2) family regulates transcription of cell cycle factors;RUNX3 regulates WNT signaling;Estrogen-dependent gene expression |
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889 4619 MYH1 False True NA |
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890 4627 MYH9 True True Translocation of SLC2A4 (GLUT4) to the plasma membrane;Regulation of actin dynamics for phagocytic cup formation;EPHA-mediated growth cone collapse;Sema4D induced cell migration and growth-cone collapse;RHO GTPases activate PKNs;RHO GTPases activate CIT;RHO GTPases Activate ROCKs;RHO GTPases activate PAKs;RHO GTPases activate PAKs |
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891 4628 MYH10 False True EPHA-mediated growth cone collapse;Sema4D induced cell migration and growth-cone collapse;RHO GTPases activate PKNs;RHO GTPases activate CIT;RHO GTPases Activate ROCKs;RHO GTPases activate PAKs;RHO GTPases activate PAKs |
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892 4629 MYH11 False True EPHA-mediated growth cone collapse;Sema4D induced cell migration and growth-cone collapse;Smooth Muscle Contraction;RHO GTPases activate PKNs;RHO GTPases activate CIT;RHO GTPases Activate ROCKs;RHO GTPases activate PAKs;RHO GTPases activate PAKs |
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893 4633 MYL2 False True Striated Muscle Contraction |
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894 4635 MYL4 False True Striated Muscle Contraction |
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895 4637 MYL6 False True EPHA-mediated growth cone collapse;Sema4D induced cell migration and growth-cone collapse;Smooth Muscle Contraction;RHO GTPases activate PKNs;RHO GTPases activate CIT;RHO GTPases Activate ROCKs;RHO GTPases activate PAKs;RHO GTPases activate PAKs |
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896 4638 MYLK False True Smooth Muscle Contraction;RHO GTPases activate PAKs;RHO GTPases activate PAKs |
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897 4641 MYO1C False True Translocation of SLC2A4 (GLUT4) to the plasma membrane;Regulation of actin dynamics for phagocytic cup formation;B-WICH complex positively regulates rRNA expression |
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898 4643 MYO1E False True NA |
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899 4644 MYO5A False True Translocation of SLC2A4 (GLUT4) to the plasma membrane;Regulation of actin dynamics for phagocytic cup formation;Insulin processing |
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900 4645 MYO5B False True Vasopressin regulates renal water homeostasis via Aquaporins |
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901 4646 MYO6 False True Gap junction degradation;Trafficking of AMPA receptors |
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902 4654 MYOD1 False True CDO in myogenesis;CDO in myogenesis |
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903 4659 PPP1R12A False True Regulation of PLK1 Activity at G2/M Transition;RHO GTPases activate PKNs;RHO GTPases activate PKNs;RHO GTPases activate CIT;RHO GTPases Activate ROCKs;RHO GTPases activate PAKs;RHO GTPases activate PAKs |
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904 4660 PPP1R12B False True Regulation of PLK1 Activity at G2/M Transition;RHO GTPases activate PKNs;RHO GTPases activate PKNs;RHO GTPases activate CIT;RHO GTPases Activate ROCKs;RHO GTPases activate PAKs;RHO GTPases activate PAKs |
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905 4664 NAB1 False True NA |
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906 4665 NAB2 False True NA |
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907 4666 NACA False True NA |
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908 4670 HNRNPM False True FGFR2 alternative splicing;mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA |
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909 4673 NAP1L1 False True NA |
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910 4676 NAP1L4 False True NA |
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911 4677 NARS False True Cytosolic tRNA aminoacylation |
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912 4686 NCBP1 False True Cleavage of Growing Transcript in the Termination Region ;SLBP independent Processing of Histone Pre-mRNAs;Formation of RNA Pol II elongation complex ;Formation of the Early Elongation Complex;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Formation of HIV elongation complex in the absence of HIV Tat;Formation of the HIV-1 Early Elongation Complex;Formation of HIV-1 elongation complex containing HIV-1 Tat;Abortive elongation of HIV-1 transcript in the absence of Tat;snRNP Assembly;RNA Polymerase II Pre-transcription Events;FGFR2 alternative splicing;RNA polymerase II transcribes snRNA genes;mRNA Capping;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;mRNA 3'-end processing;Processing of Capped Intron-Containing Pre-mRNA;SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs;Processing of Intronless Pre-mRNAs;Signaling by FGFR2 IIIa TM;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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913 4689 NCF4 False True ROS, RNS production in phagocytes;Cross-presentation of particulate exogenous antigens (phagosomes);Detoxification of Reactive Oxygen Species;VEGFA-VEGFR2 Pathway;RHO GTPases Activate NADPH Oxidases |
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914 4690 NCK1 False True Downstream signal transduction;Generation of second messenger molecules;Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;Nephrin family interactions;DCC mediated attractive signaling;DCC mediated attractive signaling;Activation of RAC1;VEGFA-VEGFR2 Pathway;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
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915 4691 NCL False True Major pathway of rRNA processing in the nucleolus and cytosol |
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916 4702 NDUFA8 False True Respiratory electron transport;Complex I biogenesis |
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917 4704 NDUFA9 False True Respiratory electron transport;Complex I biogenesis |
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918 4706 NDUFAB1 False True Glyoxylate metabolism and glycine degradation;Respiratory electron transport;Complex I biogenesis;Mitochondrial Fatty Acid Beta-Oxidation |
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919 4707 NDUFB1 False True Respiratory electron transport;Complex I biogenesis |
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920 4708 NDUFB2 False True Respiratory electron transport;Complex I biogenesis |
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921 4713 NDUFB7 False True Respiratory electron transport;Complex I biogenesis |
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922 4723 NDUFV1 False True Respiratory electron transport;Complex I biogenesis |
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923 4724 NDUFS4 False True Respiratory electron transport;Complex I biogenesis |
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924 4733 DRG1 False True NA |
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925 4734 NEDD4 False True ISG15 antiviral mechanism;Downregulation of ERBB4 signaling;Regulation of PTEN localization;Regulation of PTEN stability and activity;Antigen processing: Ubiquitination & Proteasome degradation |
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926 4735 SEPT2 False True Anchoring of the basal body to the plasma membrane |
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927 4736 RPL10A False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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928 4741 NEFM False True NA |
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929 4747 NEFL False True Unblocking of NMDA receptors, glutamate binding and activation;Unblocking of NMDA receptors, glutamate binding and activation;Ras activation upon Ca2+ influx through NMDA receptor;RAF/MAP kinase cascade;Negative regulation of NMDA receptor-mediated neuronal transmission;Long-term potentiation |
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930 4758 NEU1 False True Glycosphingolipid metabolism;Sialic acid metabolism;Defective NEU1 causes sialidosis;Neutrophil degranulation |
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931 4775 NFATC3 False True Calcineurin activates NFAT;Calcineurin activates NFAT;FCERI mediated Ca+2 mobilization;CLEC7A (Dectin-1) induces NFAT activation |
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932 4776 NFATC4 False True NA |
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933 4779 NFE2L1 False True NA |
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934 4782 NFIC False True RNA Polymerase III Transcription Termination;RNA Polymerase III Abortive And Retractive Initiation |
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935 4790 NFKB1 False True Activation of NF-kappaB in B cells;RIP-mediated NFkB activation via ZBP1;Regulated proteolysis of p75NTR;Downstream TCR signaling;NF-kB is activated and signals survival;Senescence-Associated Secretory Phenotype (SASP);FCERI mediated NF-kB activation;DEx/H-box helicases activate type I IFN and inflammatory cytokines production ;PKMTs methylate histone lysines;Transcriptional regulation of white adipocyte differentiation;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;Interleukin-1 processing;IkBA variant leads to EDA-ID;CLEC7A (Dectin-1) signaling;CD209 (DC-SIGN) signaling;CLEC7A/inflammasome pathway;MAP3K8 (TPL2)-dependent MAPK1/3 activation;Neutrophil degranulation;The NLRP3 inflammasome;Interleukin-1 signaling;TRAF6 mediated NF-kB activation |
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936 4792 NFKBIA False True Activation of NF-kappaB in B cells;RIP-mediated NFkB activation via ZBP1;Downstream TCR signaling;NF-kB is activated and signals survival;FCERI mediated NF-kB activation;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;SUMOylation of immune response proteins;IkBA variant leads to EDA-ID;CLEC7A (Dectin-1) signaling;Ub-specific processing proteases;Interleukin-1 signaling;TRAF6 mediated NF-kB activation |
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937 4794 NFKBIE False True Activation of NF-kappaB in B cells |
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938 4798 NFRKB False True UCH proteinases;DNA Damage Recognition in GG-NER |
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939 4800 NFYA False True PPARA activates gene expression;Activation of gene expression by SREBF (SREBP);Activation of gene expression by SREBF (SREBP);ATF4 activates genes;ATF6 (ATF6-alpha) activates chaperone genes;FOXO-mediated transcription of cell death genes |
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940 4801 NFYB False True PPARA activates gene expression;Activation of gene expression by SREBF (SREBP);Activation of gene expression by SREBF (SREBP);ATF4 activates genes;ATF6 (ATF6-alpha) activates chaperone genes;FOXO-mediated transcription of cell death genes |
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941 4802 NFYC False True PPARA activates gene expression;Activation of gene expression by SREBF (SREBP);Activation of gene expression by SREBF (SREBP);ATF4 activates genes;ATF6 (ATF6-alpha) activates chaperone genes;FOXO-mediated transcription of cell death genes |
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942 4815 NINJ2 False True NA |
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943 4817 NIT1 False True NA |
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944 4818 NKG7 False True NA |
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945 4830 NME1 False True Interconversion of nucleotide di- and triphosphates |
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946 4831 NME2 False True Interconversion of nucleotide di- and triphosphates;Neutrophil degranulation |
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947 4839 NOP2 False True rRNA modification in the nucleus and cytosol;TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation |
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948 4841 NONO False True NA |
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949 4843 NOS2 False True ROS, RNS production in phagocytes;Nitric oxide stimulates guanylate cyclase;Interleukin-4 and Interleukin-13 signaling;Peroxisomal protein import;Peroxisomal protein import |
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950 4846 NOS3 False True ROS, RNS production in phagocytes;Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation;eNOS activation;NOSTRIN mediated eNOS trafficking;NOSIP mediated eNOS trafficking;Nitric oxide stimulates guanylate cyclase;VEGFR2 mediated vascular permeability |
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951 4848 CNOT2 False True Deadenylation of mRNA;TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain |
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952 4849 CNOT3 False True Deadenylation of mRNA;TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain |
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953 4860 PNP True True Neutrophil degranulation;Purine salvage;Purine catabolism |
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954 4862 NPAS2 False True BMAL1:CLOCK,NPAS2 activates circadian gene expression;BMAL1:CLOCK,NPAS2 activates circadian gene expression;PPARA activates gene expression;PPARA activates gene expression;Circadian Clock;Circadian Clock |
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955 4863 NPAT False True NA |
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956 4868 NPHS1 False True Nephrin family interactions;Nephrin family interactions |
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957 4869 NPM1 False True Nuclear import of Rev protein;Nuclear import of Rev protein;SUMOylation of transcription cofactors;Deposition of new CENPA-containing nucleosomes at the centromere;TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain;TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation |
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958 4898 NRD1 False True NA |
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959 4904 YBX1 False True mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;Noncanonical activation of NOTCH3 |
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960 4914 NTRK1 False True PLC-gamma1 signalling;Signalling to RAS;Frs2-mediated activation;Frs2-mediated activation;ARMS-mediated activation;ARMS-mediated activation;Retrograde neurotrophin signalling;Retrograde neurotrophin signalling;NGF-independant TRKA activation;TRKA activation by NGF;TRKA activation by NGF;Signalling to p38 via RIT and RIN;PI3K/AKT activation;PI3K/AKT activation;Signalling to STAT3 |
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961 4915 NTRK2 False True NGF-independant TRKA activation;BDNF activates NTRK2 (TRKB) signaling;NTF3 activates NTRK2 (TRKB) signaling;NTF4 activates NTRK2 (TRKB) signaling;Activated NTRK2 signals through RAS;Activated NTRK2 signals through PLCG1;Activated NTRK2 signals through PLCG1;Activated NTRK2 signals through PI3K;Activated NTRK2 signals through FRS2 and FRS3;Activated NTRK2 signals through FRS2 and FRS3;Activated NTRK2 signals through FYN;NTRK2 activates RAC1;NTRK2 activates RAC1;Activated NTRK2 signals through CDK5 |
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962 4916 NTRK3 False True Receptor-type tyrosine-protein phosphatases;NTF3 activates NTRK3 signaling;NTF3 activates NTRK3 signaling;Signaling by NTRK3 (TRKC);Activated NTRK3 signals through PLCG1;Activated NTRK3 signals through PLCG1;Activated NTRK3 signals through RAS;Activated NTRK3 signals through PI3K;Activated NTRK3 signals through PI3K;NTRK3 as a dependence receptor |
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963 4919 ROR1 False True WNT5A-dependent internalization of FZD2, FZD5 and ROR2 |
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964 4920 ROR2 False True PCP/CE pathway;WNT5A-dependent internalization of FZD2, FZD5 and ROR2 |
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965 4921 DDR2 False True Non-integrin membrane-ECM interactions |
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966 4924 NUCB1 False True Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation |
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967 4926 NUMA1 False True Recruitment of NuMA to mitotic centrosomes;Mitotic Prophase |
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968 4928 NUP98 False True ISG15 antiviral mechanism;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Rev-mediated nuclear export of HIV RNA;Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Viral Messenger RNA Synthesis;NEP/NS2 Interacts with the Cellular Export Machinery;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;snRNP Assembly;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;SUMOylation of DNA damage response and repair proteins;SUMOylation of ubiquitinylation proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;SUMOylation of SUMOylation proteins;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins;Transcriptional regulation by small RNAs;RHO GTPases Activate Formins;tRNA processing in the nucleus;Mitotic Prometaphase |
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969 4931 NVL False True NA |
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970 4942 OAT False True Amino acid synthesis and interconversion (transamination) |
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971 4967 OGDH False True Glyoxylate metabolism and glycine degradation;Lysine catabolism;Citric acid cycle (TCA cycle) |
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972 4976 OPA1 False True Regulation of Apoptosis |
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973 4995 NA False True Olfactory Signaling Pathway |
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974 4999 ORC2 False True E2F-enabled inhibition of pre-replication complex formation;Activation of ATR in response to replication stress;Assembly of the ORC complex at the origin of replication;CDC6 association with the ORC:origin complex;CDT1 association with the CDC6:ORC:origin complex;Assembly of the pre-replicative complex;Orc1 removal from chromatin;Activation of the pre-replicative complex |
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975 5000 ORC4 False True E2F-enabled inhibition of pre-replication complex formation;Activation of ATR in response to replication stress;Assembly of the ORC complex at the origin of replication;CDC6 association with the ORC:origin complex;CDT1 association with the CDC6:ORC:origin complex;Assembly of the pre-replicative complex;Orc1 removal from chromatin;Activation of the pre-replicative complex |
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976 5001 ORC5 False True E2F-enabled inhibition of pre-replication complex formation;Activation of ATR in response to replication stress;Assembly of the ORC complex at the origin of replication;CDC6 association with the ORC:origin complex;CDT1 association with the CDC6:ORC:origin complex;Assembly of the pre-replicative complex;Orc1 removal from chromatin;Activation of the pre-replicative complex |
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977 5004 ORM1 True True Platelet degranulation ;Neutrophil degranulation |
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978 5005 ORM2 False True Platelet degranulation ;Neutrophil degranulation |
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979 5019 OXCT1 False True Utilization of Ketone Bodies |
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980 5034 P4HB False True Collagen biosynthesis and modifying enzymes;Detoxification of Reactive Oxygen Species;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Hedgehog ligand biogenesis;VLDL assembly;Post-translational protein phosphorylation;Chylomicron assembly;Interleukin-12 signaling;Interleukin-23 signaling |
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981 5036 PA2G4 False True Neutrophil degranulation |
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982 5037 PEBP1 False True MAP2K and MAPK activation;Negative regulation of MAPK pathway;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF |
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983 5042 PABPC3 False True NA |
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984 5048 PAFAH1B1 False True Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;RHO GTPases Activate Formins;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;AURKA Activation by TPX2 |
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985 5049 PAFAH1B2 False True Neutrophil degranulation;COPI-independent Golgi-to-ER retrograde traffic |
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986 5052 PRDX1 True True Detoxification of Reactive Oxygen Species;TP53 Regulates Metabolic Genes;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models |
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987 5054 SERPINE1 False True Platelet degranulation ;BMAL1:CLOCK,NPAS2 activates circadian gene expression;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;ECM proteoglycans;Dissolution of Fibrin Clot |
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988 5062 PAK2 False True Nef and signal transduction;Generation of second messenger molecules;Regulation of PAK-2p34 activity by PS-GAP/RHG10;Regulation of activated PAK-2p34 by proteasome mediated degradation;Stimulation of the cell death response by PAK-2p34;FCERI mediated MAPK activation;FCERI mediated MAPK activation;CD28 dependent Vav1 pathway;Ephrin signaling;Sema3A PAK dependent Axon repulsion;Activation of RAC1;VEGFA-VEGFR2 Pathway;Smooth Muscle Contraction;VEGFR2 mediated vascular permeability;CD209 (DC-SIGN) signaling;RHO GTPases activate PAKs;RHO GTPases activate PAKs;MAPK6/MAPK4 signaling;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation |
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989 5071 PARK2 False True Pink/Parkin Mediated Mitophagy;Josephin domain DUBs;Amyloid fiber formation;Antigen processing: Ubiquitination & Proteasome degradation |
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990 5074 PAWR False True NA |
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991 5093 PCBP1 False True mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA |
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992 5094 PCBP2 False True mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA;Negative regulators of DDX58/IFIH1 signaling |
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993 5097 PCDH1 False True NA |
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994 5108 PCM1 False True Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;AURKA Activation by TPX2 |
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995 5110 PCMT1 False True Protein repair |
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996 5111 PCNA False True Translesion synthesis by REV1;Recognition of DNA damage by PCNA-containing replication complex;Translesion Synthesis by POLH;Transcription of E2F targets under negative control by DREAM complex;Polymerase switching on the C-strand of the telomere;Processive synthesis on the C-strand of the telomere;Telomere C-strand (Lagging Strand) Synthesis;Removal of the Flap Intermediate from the C-strand;SUMOylation of DNA replication proteins;Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha);Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta);Activation of E2F1 target genes at G1/S;PCNA-Dependent Long Patch Base Excision Repair;Translesion synthesis by POLK;Translesion synthesis by POLI;Termination of translesion DNA synthesis;HDR through Homologous Recombination (HRR);Gap-filling DNA repair synthesis and ligation in GG-NER;Dual Incision in GG-NER;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest;Polymerase switching;Removal of the Flap Intermediate;Processive synthesis on the lagging strand;E3 ubiquitin ligases ubiquitinate target proteins |
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997 5116 PCNT False True Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;AURKA Activation by TPX2 |
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998 5127 CDK16 False True NA |
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999 5129 CDK18 False True NA |
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1000 5139 PDE3A False True cGMP effects;G alpha (s) signalling events |
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1001 5142 PDE4B False True DARPP-32 events;G alpha (s) signalling events |
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1002 5159 PDGFRB False True PIP3 activates AKT signaling;Downstream signal transduction;Signaling by PDGF;Constitutive Signaling by Aberrant PI3K in Cancer;RAF/MAP kinase cascade;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
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1003 5160 PDHA1 False True Regulation of pyruvate dehydrogenase (PDH) complex;Glyoxylate metabolism and glycine degradation;Signaling by Retinoic Acid;Pyruvate metabolism |
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1004 5162 PDHB False True Regulation of pyruvate dehydrogenase (PDH) complex;Glyoxylate metabolism and glycine degradation;Signaling by Retinoic Acid;Pyruvate metabolism |
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1005 5168 ENPP2 False True Vitamin B5 (pantothenate) metabolism |
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1006 5173 PDYN False True Opioid Signalling;G-protein activation;Peptide ligand-binding receptors;G alpha (i) signalling events |
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1007 5178 PEG3 False True NA |
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1008 5184 PEPD False True NA |
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1009 5197 NA False True Common Pathway of Fibrin Clot Formation;Cell surface interactions at the vascular wall |
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1010 5198 PFAS False True Purine ribonucleoside monophosphate biosynthesis |
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1011 5202 PFDN2 False True Prefoldin mediated transfer of substrate to CCT/TriC |
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1012 5208 PFKFB2 False True Glycolysis |
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1013 5213 PFKM False True Glycolysis |
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1014 5214 PFKP False True Glycolysis |
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1015 5216 PFN1 False True Platelet degranulation ;Signaling by ROBO receptors;PCP/CE pathway;RHO GTPases Activate Formins;RHO GTPases Activate Formins |
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1016 5217 PFN2 False True Signaling by ROBO receptors;RHO GTPases Activate Formins;RHO GTPases Activate Formins |
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1017 5218 CDK14 False True NA |
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1018 5223 PGAM1 False True Neutrophil degranulation;Glycolysis;Gluconeogenesis |
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1019 5224 PGAM2 False True Glycolysis;Gluconeogenesis |
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1020 5226 PGD False True Pentose phosphate pathway |
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1021 5230 PGK1 True True Glycolysis;Gluconeogenesis |
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1022 5232 PGK2 False True Glycolysis;Gluconeogenesis |
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1023 5236 PGM1 False True Glycogen synthesis;Defective PGM1 causes PGM1-CDG (CDG1t);Neutrophil degranulation;Glycogen breakdown (glycogenolysis);Galactose catabolism |
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1024 5239 PGM5 False True NA |
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1025 5245 PHB False True RAF activation;Signaling by moderate kinase activity BRAF mutants;Signaling by RAS mutants;Paradoxical activation of RAF signaling by kinase inactive BRAF;Processing of SMDT1 |
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1026 5250 SLC25A3 False True NA |
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1027 5255 PHKA1 False True Glycogen breakdown (glycogenolysis);Glycogen breakdown (glycogenolysis) |
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1028 5265 SERPINA1 True True Platelet degranulation ;COPII-mediated vesicle transport;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Cargo concentration in the ER;Neutrophil degranulation;Post-translational protein phosphorylation |
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1029 5266 PI3 False True Antimicrobial peptides;Formation of the cornified envelope |
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1030 5267 SERPINA4 False True Platelet degranulation |
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1031 5268 SERPINB5 True True NA |
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1032 5270 SERPINE2 False True Intrinsic Pathway of Fibrin Clot Formation;Common Pathway of Fibrin Clot Formation;Dissolution of Fibrin Clot |
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1033 5275 SERPINB13 True True RUNX1 regulates transcription of genes involved in differentiation of keratinocytes |
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1034 5277 PIGA False True Synthesis of glycosylphosphatidylinositol (GPI) |
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1035 5284 NA True False Neutrophil degranulation |
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1036 5286 PIK3C2A False True Synthesis of PIPs at the plasma membrane;Synthesis of PIPs at the Golgi membrane;Synthesis of PIPs at the early endosome membrane;Synthesis of PIPs at the late endosome membrane;Golgi Associated Vesicle Biogenesis;Clathrin-mediated endocytosis |
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1037 5287 PIK3C2B False True Synthesis of PIPs at the plasma membrane |
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1038 5289 PIK3C3 False True PI3K Cascade;Macroautophagy;Synthesis of PIPs at the Golgi membrane;Synthesis of PIPs at the early endosome membrane;Synthesis of PIPs at the late endosome membrane;Toll Like Receptor 9 (TLR9) Cascade;RHO GTPases Activate NADPH Oxidases |
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1039 5290 PIK3CA False True PI3K Cascade;IRS-mediated signalling;GPVI-mediated activation cascade;Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants;PI3K events in ERBB4 signaling;PIP3 activates AKT signaling;Signaling by SCF-KIT;Synthesis of PIPs at the plasma membrane;GAB1 signalosome;Signaling by cytosolic FGFR1 fusion mutants;Downstream signal transduction;PI3K events in ERBB2 signaling;PI3K/AKT activation;Downstream TCR signaling;Role of phospholipids in phagocytosis;Tie2 Signaling;Constitutive Signaling by Aberrant PI3K in Cancer;DAP12 signaling;Role of LAT2/NTAL/LAB on calcium mobilization;Nephrin family interactions;Costimulation by the CD28 family;CD28 dependent PI3K/Akt signaling;G alpha (q) signalling events;VEGFA-VEGFR2 Pathway;VEGFA-VEGFR2 Pathway;Interleukin-3, Interleukin-5 and GM-CSF signaling;Constitutive Signaling by EGFRvIII;PI-3K cascade:FGFR1;PI-3K cascade:FGFR2;PI-3K cascade:FGFR3;PI-3K cascade:FGFR4;Signaling by FGFR2 in disease;Signaling by FGFR4 in disease;Signaling by FGFR1 in disease;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;MET activates PI3K/AKT signaling;Signaling by FGFR3 fusions in cancer;Signaling by FGFR3 point mutants in cancer;RET signaling;Erythropoietin activates Phosphoinositide-3-kinase (PI3K);Erythropoietin activates Phosphoinositide-3-kinase (PI3K);Activated NTRK2 signals through PI3K;Interleukin receptor SHC signaling;Regulation of signaling by CBL;Regulation of signaling by CBL;Activated NTRK3 signals through PI3K |
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1040 5292 PIM1 False True Interleukin-4 and Interleukin-13 signaling |
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1041 5296 PIK3R2 False True PI3K Cascade;IRS-mediated signalling;GPVI-mediated activation cascade;PIP3 activates AKT signaling;Interleukin-7 signaling;Interleukin-7 signaling;Signaling by SCF-KIT;Synthesis of PIPs at the plasma membrane;Downstream signal transduction;Rho GTPase cycle;PI3K/AKT activation;Downstream TCR signaling;Role of phospholipids in phagocytosis;Tie2 Signaling;Constitutive Signaling by Aberrant PI3K in Cancer;DAP12 signaling;Role of LAT2/NTAL/LAB on calcium mobilization;Nephrin family interactions;Costimulation by the CD28 family;CD28 dependent PI3K/Akt signaling;G alpha (q) signalling events;VEGFA-VEGFR2 Pathway;VEGFA-VEGFR2 Pathway;Interleukin-3, Interleukin-5 and GM-CSF signaling;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;RET signaling;Interleukin receptor SHC signaling;Regulation of signaling by CBL;Regulation of signaling by CBL |
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1042 5298 PI4KB False True Synthesis of PIPs at the Golgi membrane |
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1043 5300 PIN1 False True ISG15 antiviral mechanism;RHO GTPases Activate NADPH Oxidases;Regulation of TP53 Activity through Phosphorylation;PI5P Regulates TP53 Acetylation;Negative regulators of DDX58/IFIH1 signaling |
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1044 5304 NA True False Miscellaneous transport and binding events |
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1045 5306 PITPNA False True Role of second messengers in netrin-1 signaling;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation |
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1046 5311 PKD2 False True VxPx cargo-targeting to cilium;VxPx cargo-targeting to cilium |
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1047 5315 PKM True True Neutrophil degranulation;Glycolysis |
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1048 5317 PKP1 False True Apoptotic cleavage of cell adhesion proteins;Neutrophil degranulation;Keratinization;Formation of the cornified envelope |
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1049 5318 PKP2 False True Keratinization;Formation of the cornified envelope |
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1050 5321 PLA2G4A False True phospho-PLA2 pathway;Acyl chain remodelling of PC;Acyl chain remodeling of CL;Acyl chain remodelling of PS;Acyl chain remodelling of PE;Acyl chain remodelling of PI;Acyl chain remodelling of PG;Hydrolysis of LPC;Synthesis of PA;Arachidonic acid metabolism;ADP signalling through P2Y purinoceptor 1;Platelet sensitization by LDL;COPI-independent Golgi-to-ER retrograde traffic |
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1051 5324 NA False True NA |
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1052 5327 PLAT False True Signaling by PDGF;Dissolution of Fibrin Clot |
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1053 5339 PLEC True True Assembly of collagen fibrils and other multimeric structures;Caspase-mediated cleavage of cytoskeletal proteins;Type I hemidesmosome assembly |
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1054 5340 PLG False True Platelet degranulation ;Degradation of the extracellular matrix;Degradation of the extracellular matrix;Activation of Matrix Metalloproteinases;Signaling by PDGF;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Dissolution of Fibrin Clot |
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1055 5347 PLK1 False True Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Polo-like kinase mediated events;Golgi Cisternae Pericentriolar Stack Reorganization;Golgi Cisternae Pericentriolar Stack Reorganization;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Phosphorylation of the APC/C;Phosphorylation of Emi1;Condensation of Prophase Chromosomes;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;Regulation of PLK1 Activity at G2/M Transition;Activation of NIMA Kinases NEK9, NEK6, NEK7;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;RHO GTPases Activate Formins;Mitotic Prometaphase;Mitotic Metaphase/Anaphase Transition;Mitotic Telophase/Cytokinesis;Cyclin A/B1/B2 associated events during G2/M transition;The role of GTSE1 in G2/M progression after G2 checkpoint;AURKA Activation by TPX2 |
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1056 5349 FXYD3 False True Ion homeostasis;Ion transport by P-type ATPases |
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1057 5354 PLP1 False True NA |
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1058 5355 PLP2 False True NA |
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1059 5357 NA False True NA |
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1060 5371 PML False True SUMOylation of DNA damage response and repair proteins;SUMOylation of ubiquitinylation proteins;Regulation of TP53 Activity through Acetylation;Interferon gamma signaling;Regulation of RUNX1 Expression and Activity;Regulation of PTEN localization |
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1061 5375 PMP2 False True NA |
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1062 5376 PMP22 False True NA |
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1063 5395 PMS2 False True Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha);Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta);Defective Mismatch Repair Associated With MLH1;Defective Mismatch Repair Associated With PMS2;TP53 Regulates Transcription of DNA Repair Genes |
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1064 5406 PNLIP False True Digestion of dietary lipid;Retinoid metabolism and transport |
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1065 5407 PNLIPRP1 False True Digestion of dietary lipid |
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1066 5422 POLA1 False True Inhibition of replication initiation of damaged DNA by RB1/E2F1;Polymerase switching on the C-strand of the telomere;Telomere C-strand synthesis initiation;Activation of E2F1 target genes at G1/S;DNA replication initiation;Activation of the pre-replicative complex;Polymerase switching;Removal of the Flap Intermediate;Processive synthesis on the lagging strand |
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1067 5427 POLE2 False True Recognition of DNA damage by PCNA-containing replication complex;Telomere C-strand synthesis initiation;PCNA-Dependent Long Patch Base Excision Repair;Termination of translesion DNA synthesis;HDR through Homologous Recombination (HRR);Gap-filling DNA repair synthesis and ligation in GG-NER;Dual Incision in GG-NER;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;DNA replication initiation;Activation of the pre-replicative complex |
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1068 5429 POLH False True Translesion Synthesis by POLH;Termination of translesion DNA synthesis;HDR through Homologous Recombination (HRR) |
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1069 5433 POLR2D False True Formation of RNA Pol II elongation complex ;Formation of the Early Elongation Complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of the HIV-1 Early Elongation Complex;RNA Pol II CTD phosphorylation and interaction with CE during HIV infection;HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;Formation of HIV-1 elongation complex containing HIV-1 Tat;Formation of HIV-1 elongation complex containing HIV-1 Tat;Pausing and recovery of Tat-mediated HIV elongation;Abortive elongation of HIV-1 transcript in the absence of Tat;Tat-mediated HIV elongation arrest and recovery;Tat-mediated elongation of the HIV-1 transcript;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;Viral Messenger RNA Synthesis;MicroRNA (miRNA) biogenesis;Transcriptional regulation of pluripotent stem cells;Transcriptional regulation by small RNAs;PIWI-interacting RNA (piRNA) biogenesis;Activation of anterior HOX genes in hindbrain development during early embryogenesis;RNA Polymerase II Pre-transcription Events;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;TP53 Regulates Transcription of DNA Repair Genes;FGFR2 alternative splicing;RNA polymerase II transcribes snRNA genes;RNA polymerase II transcribes snRNA genes;mRNA Capping;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;Processing of Capped Intron-Containing Pre-mRNA;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Elongation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Pol II CTD phosphorylation and interaction with CE;Signaling by FGFR2 IIIa TM;Estrogen-dependent gene expression |
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1070 5434 POLR2E False True Formation of RNA Pol II elongation complex ;Formation of the Early Elongation Complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of the HIV-1 Early Elongation Complex;RNA Pol II CTD phosphorylation and interaction with CE during HIV infection;HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;Formation of HIV-1 elongation complex containing HIV-1 Tat;Formation of HIV-1 elongation complex containing HIV-1 Tat;Pausing and recovery of Tat-mediated HIV elongation;Abortive elongation of HIV-1 transcript in the absence of Tat;Tat-mediated HIV elongation arrest and recovery;Tat-mediated elongation of the HIV-1 transcript;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;Viral Messenger RNA Synthesis;Cytosolic sensors of pathogen-associated DNA ;MicroRNA (miRNA) biogenesis;NoRC negatively regulates rRNA expression;Transcriptional regulation of pluripotent stem cells;B-WICH complex positively regulates rRNA expression;Transcriptional regulation by small RNAs;PIWI-interacting RNA (piRNA) biogenesis;Activation of anterior HOX genes in hindbrain development during early embryogenesis;RNA Polymerase II Pre-transcription Events;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;TP53 Regulates Transcription of DNA Repair Genes;FGFR2 alternative splicing;RNA polymerase II transcribes snRNA genes;RNA polymerase II transcribes snRNA genes;mRNA Capping;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;Processing of Capped Intron-Containing Pre-mRNA;RNA Polymerase I Transcription Initiation;RNA Polymerase I Transcription Initiation;RNA Polymerase I Promoter Escape;RNA Polymerase II Promoter Escape;RNA Polymerase I Chain Elongation;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase III Chain Elongation;RNA Polymerase I Transcription Termination;RNA Polymerase III Transcription Termination;RNA Polymerase III Abortive And Retractive Initiation;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Elongation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Polymerase III Transcription Initiation From Type 1 Promoter;RNA Polymerase III Transcription Initiation From Type 1 Promoter;RNA Polymerase III Transcription Initiation From Type 2 Promoter;RNA Polymerase III Transcription Initiation From Type 2 Promoter;RNA Polymerase III Transcription Initiation From Type 3 Promoter;RNA Polymerase III Transcription Initiation From Type 3 Promoter;RNA Pol II CTD phosphorylation and interaction with CE;Signaling by FGFR2 IIIa TM;Estrogen-dependent gene expression |
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1071 5451 POU2F1 False True Interleukin-4 and Interleukin-13 signaling;RNA polymerase II transcribes snRNA genes;RNA polymerase II transcribes snRNA genes;RNA Polymerase III Abortive And Retractive Initiation;RNA Polymerase III Transcription Initiation From Type 3 Promoter;RNA Polymerase III Transcription Initiation From Type 3 Promoter;Estrogen-dependent gene expression |
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1072 5464 PPA1 False True Cytosolic tRNA aminoacylation;Pyrophosphate hydrolysis |
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1073 5465 PPARA False True RORA activates gene expression;BMAL1:CLOCK,NPAS2 activates circadian gene expression;PPARA activates gene expression;PPARA activates gene expression;Transcriptional activation of mitochondrial biogenesis;Activation of gene expression by SREBF (SREBP);Transcriptional regulation of white adipocyte differentiation;Nuclear Receptor transcription pathway;Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha);Circadian Clock;SUMOylation of intracellular receptors |
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1074 5467 PPARD False True Import of palmitoyl-CoA into the mitochondrial matrix;Regulation of pyruvate dehydrogenase (PDH) complex;Nuclear Receptor transcription pathway;Signaling by Retinoic Acid |
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1075 5473 PPBP False True Platelet degranulation ;Chemokine receptors bind chemokines;G alpha (i) signalling events;Neutrophil degranulation |
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1076 5476 CTSA False True Glycosphingolipid metabolism;MHC class II antigen presentation;Sialic acid metabolism;Neutrophil degranulation |
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1077 5478 PPIA True True Platelet degranulation ;Uncoating of the HIV Virion;Budding and maturation of HIV virion;Integration of provirus;Early Phase of HIV Life Cycle;Minus-strand DNA synthesis;Plus-strand DNA synthesis;Binding and entry of HIV virion;Assembly Of The HIV Virion;APOBEC3G mediated resistance to HIV-1 infection;Calcineurin activates NFAT;Basigin interactions;Neutrophil degranulation;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation |
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1078 5479 PPIB True True Collagen biosynthesis and modifying enzymes |
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1079 5481 PPID False True ESR-mediated signaling |
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1080 5494 PPM1A False True Downregulation of SMAD2/3:SMAD4 transcriptional activity;Energy dependent regulation of mTOR by LKB1-AMPK |
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1081 5495 PPM1B False True ISG15 antiviral mechanism |
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1082 5496 PPM1G False True NA |
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1083 5499 PPP1CA False True Triglyceride catabolism;DARPP-32 events;Downregulation of TGF-beta receptor signaling;Circadian Clock |
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1084 5500 PPP1CB False True Triglyceride catabolism;Downregulation of TGF-beta receptor signaling;Regulation of PLK1 Activity at G2/M Transition;Circadian Clock;RHO GTPases activate PKNs;RHO GTPases activate PKNs;RHO GTPases activate CIT;RHO GTPases Activate ROCKs;RHO GTPases activate PAKs;RHO GTPases activate PAKs |
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1085 5501 PPP1CC False True Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Triglyceride catabolism;Downregulation of TGF-beta receptor signaling;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;Circadian Clock;RHO GTPases Activate Formins;Mitotic Prometaphase |
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1086 5504 PPP1R2 False True NA |
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1087 5509 PPP1R3D False True NA |
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1088 5511 PPP1R8 False True NA |
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1089 5515 PPP2CA False True Inhibition of replication initiation of damaged DNA by RB1/E2F1;Spry regulation of FGF signaling;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Integration of energy metabolism;PP2A-mediated dephosphorylation of key metabolic factors;DARPP-32 events;Degradation of beta-catenin by the destruction complex;Beta-catenin phosphorylation cascade;ERK/MAPK targets;ERKs are inactivated;MASTL Facilitates Mitotic Progression;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;Initiation of Nuclear Envelope Reformation;CTLA4 inhibitory signaling;Platelet sensitization by LDL;Disassembly of the destruction complex and recruitment of AXIN to the membrane;Disassembly of the destruction complex and recruitment of AXIN to the membrane;Misspliced GSK3beta mutants stabilize beta-catenin;S33 mutants of beta-catenin aren't phosphorylated;S37 mutants of beta-catenin aren't phosphorylated;S45 mutants of beta-catenin aren't phosphorylated;T41 mutants of beta-catenin aren't phosphorylated;APC truncation mutants have impaired AXIN binding;AXIN missense mutants destabilize the destruction complex;Truncations of AMER1 destabilize the destruction complex;RHO GTPases Activate Formins;RAF activation;Negative regulation of MAPK pathway;Regulation of TP53 Degradation;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Mitotic Prometaphase;Cyclin D associated events in G1;Cyclin A/B1/B2 associated events during G2/M transition;Glycolysis;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1090 5518 PPP2R1A False True Inhibition of replication initiation of damaged DNA by RB1/E2F1;Spry regulation of FGF signaling;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Integration of energy metabolism;PP2A-mediated dephosphorylation of key metabolic factors;DARPP-32 events;Degradation of beta-catenin by the destruction complex;Beta-catenin phosphorylation cascade;ERK/MAPK targets;ERKs are inactivated;MASTL Facilitates Mitotic Progression;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;Regulation of PLK1 Activity at G2/M Transition;Initiation of Nuclear Envelope Reformation;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;CTLA4 inhibitory signaling;Platelet sensitization by LDL;Disassembly of the destruction complex and recruitment of AXIN to the membrane;Disassembly of the destruction complex and recruitment of AXIN to the membrane;Misspliced GSK3beta mutants stabilize beta-catenin;S33 mutants of beta-catenin aren't phosphorylated;S37 mutants of beta-catenin aren't phosphorylated;S45 mutants of beta-catenin aren't phosphorylated;T41 mutants of beta-catenin aren't phosphorylated;APC truncation mutants have impaired AXIN binding;AXIN missense mutants destabilize the destruction complex;Truncations of AMER1 destabilize the destruction complex;Anchoring of the basal body to the plasma membrane;RHO GTPases Activate Formins;RAF activation;Negative regulation of MAPK pathway;Regulation of TP53 Degradation;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Mitotic Prometaphase;Cyclin D associated events in G1;Cyclin A/B1/B2 associated events during G2/M transition;Glycolysis;AURKA Activation by TPX2;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1091 5520 PPP2R2A False True Initiation of Nuclear Envelope Reformation;Cyclin D associated events in G1;Cyclin A/B1/B2 associated events during G2/M transition;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1092 5530 PPP3CA False True DARPP-32 events;Calcineurin activates NFAT;Calcineurin activates NFAT;FCERI mediated Ca+2 mobilization;Ca2+ pathway;CLEC7A (Dectin-1) induces NFAT activation |
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1093 5534 PPP3R1 False True Activation of BAD and translocation to mitochondria ;DARPP-32 events;Calcineurin activates NFAT;Calcineurin activates NFAT;FCERI mediated Ca+2 mobilization;Ca2+ pathway;CLEC7A (Dectin-1) induces NFAT activation |
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1094 5536 PPP5C False True Negative regulation of MAPK pathway;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;ESR-mediated signaling |
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1095 5538 PPT1 False True Fatty acyl-CoA biosynthesis |
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1096 5546 PRCC False True mRNA Splicing - Major Pathway |
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1097 5547 PRCP False True Intrinsic Pathway of Fibrin Clot Formation;Neutrophil degranulation |
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1098 5550 PREP False True NA |
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1099 5562 PRKAA1 False True Macroautophagy;Energy dependent regulation of mTOR by LKB1-AMPK;TP53 Regulates Metabolic Genes;Regulation of TP53 Activity through Phosphorylation;Activation of AMPK downstream of NMDARs |
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1100 5563 PRKAA2 False True Translocation of SLC2A4 (GLUT4) to the plasma membrane;Macroautophagy;AMPK inhibits chREBP transcriptional activation activity;AMPK inhibits chREBP transcriptional activation activity;Import of palmitoyl-CoA into the mitochondrial matrix;Activation of PPARGC1A (PGC-1alpha) by phosphorylation;Energy dependent regulation of mTOR by LKB1-AMPK;TP53 Regulates Metabolic Genes;Regulation of TP53 Activity through Phosphorylation;Activation of AMPK downstream of NMDARs |
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1101 5567 PRKACB False True PKA-mediated phosphorylation of CREB;PKA-mediated phosphorylation of key metabolic factors;Triglyceride catabolism;PKA activation;PKA activation in glucagon signalling;DARPP-32 events;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Rap1 signalling;Regulation of insulin secretion;Vasopressin regulates renal water homeostasis via Aquaporins;VEGFA-VEGFR2 Pathway;CREB1 phosphorylation through the activation of Adenylate Cyclase;CREB1 phosphorylation through the activation of Adenylate Cyclase;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'off' state;CD209 (DC-SIGN) signaling;MAPK6/MAPK4 signaling;Glycolysis;RET signaling;HDL assembly;ROBO receptors bind AKAP5;Factors involved in megakaryocyte development and platelet production |
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1102 5578 PRKCA False True Calmodulin induced events;Disinhibition of SNARE formation;SHC1 events in ERBB2 signaling;Signaling by SCF-KIT;Regulation of KIT signaling;EGFR Transactivation by Gastrin;Inactivation, recovery and regulation of the phototransduction cascade;Syndecan interactions;Acetylcholine regulates insulin secretion;Ca2+ pathway;Trafficking of GluR2-containing AMPA receptors;G alpha (z) signalling events;Depolymerisation of the Nuclear Lamina;HuR (ELAVL1) binds and stabilizes mRNA;WNT5A-dependent internalization of FZD4;VEGFR2 mediated cell proliferation;RHO GTPases Activate NADPH Oxidases;Response to elevated platelet cytosolic Ca2+;RET signaling;ROBO receptors bind AKAP5;ROBO receptors bind AKAP5 |
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1103 5579 PRKCB False True Disinhibition of SNARE formation;Activation of NF-kappaB in B cells;Trafficking of GluR2-containing AMPA receptors;G alpha (z) signalling events;Depolymerisation of the Nuclear Lamina;WNT5A-dependent internalization of FZD4;VEGFR2 mediated cell proliferation;RHO GTPases Activate NADPH Oxidases;Response to elevated platelet cytosolic Ca2+;RUNX1 regulates transcription of genes involved in differentiation of myeloid cells |
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1104 5580 PRKCD False True Apoptotic cleavage of cellular proteins;Calmodulin induced events;Effects of PIP2 hydrolysis;SHC1 events in ERBB2 signaling;DAG and IP3 signaling;Role of phospholipids in phagocytosis;G alpha (z) signalling events;HuR (ELAVL1) binds and stabilizes mRNA;VEGFR2 mediated cell proliferation;CLEC7A (Dectin-1) signaling;RHO GTPases Activate NADPH Oxidases;Neutrophil degranulation;Interferon gamma signaling |
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1105 5581 PRKCE False True Effects of PIP2 hydrolysis;SHC1 events in ERBB2 signaling;DAG and IP3 signaling;Role of phospholipids in phagocytosis;G alpha (z) signalling events |
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1106 5582 PRKCG False True Calmodulin induced events;Disinhibition of SNARE formation;Trafficking of GluR2-containing AMPA receptors;G alpha (z) signalling events;WNT5A-dependent internalization of FZD4;Response to elevated platelet cytosolic Ca2+ |
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1107 5583 PRKCH False True Effects of PIP2 hydrolysis;G alpha (z) signalling events |
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1108 5584 PRKCI False True Pre-NOTCH Transcription and Translation;p75NTR recruits signalling complexes;Tight junction interactions |
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1109 5585 PKN1 False True RHO GTPases activate PKNs;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
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1110 5586 PKN2 False True RHO GTPases activate PKNs |
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1111 5587 PRKD1 False True Sphingolipid de novo biosynthesis |
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1112 5588 PRKCQ False True Apoptotic cleavage of cellular proteins;Effects of PIP2 hydrolysis;Downstream TCR signaling;Inactivation, recovery and regulation of the phototransduction cascade;FCERI mediated NF-kB activation;FCERI mediated NF-kB activation;Netrin-1 signaling;G alpha (z) signalling events;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function |
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1113 5589 PRKCSH False True Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);N-glycan trimming in the ER and Calnexin/Calreticulin cycle;Advanced glycosylation endproduct receptor signaling;Post-translational protein phosphorylation;Calnexin/calreticulin cycle |
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1114 5590 PRKCZ False True GPVI-mediated activation cascade;TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);VEGFR2 mediated cell proliferation;RHO GTPases Activate NADPH Oxidases |
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1115 5591 PRKDC False True Cytosolic sensors of pathogen-associated DNA ;IRF3-mediated induction of type I IFN;Nonhomologous End-Joining (NHEJ);E3 ubiquitin ligases ubiquitinate target proteins |
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1116 5593 PRKG2 False True Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation;Ca2+ pathway;cGMP effects;cGMP effects |
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1117 5594 MAPK1 False True phospho-PLA2 pathway;RAF-independent MAPK1/3 activation;MAPK1 (ERK2) activation;Spry regulation of FGF signaling;Golgi Cisternae Pericentriolar Stack Reorganization;Frs2-mediated activation;ERK/MAPK targets;ERK/MAPK targets;ERKs are inactivated;Regulation of actin dynamics for phagocytic cup formation;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);Oncogene Induced Senescence;Oncogene Induced Senescence;FCERI mediated MAPK activation;Regulation of HSF1-mediated heat shock response;NCAM signaling for neurite out-growth;Recycling pathway of L1;RSK activation;Signal transduction by L1;Activation of the AP-1 family of transcription factors;Thrombin signalling through proteinase activated receptors (PARs);Negative regulation of FGFR1 signaling;Negative regulation of FGFR2 signaling;Negative regulation of FGFR3 signaling;Negative regulation of FGFR4 signaling;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate NADPH Oxidases;RAF/MAP kinase cascade;MAP2K and MAPK activation;Negative feedback regulation of MAPK pathway;Negative regulation of MAPK pathway;Neutrophil degranulation;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Signal attenuation;Advanced glycosylation endproduct receptor signaling;Gastrin-CREB signalling pathway via PKC and MAPK;ESR-mediated signaling;RUNX2 regulates osteoblast differentiation;Regulation of PTEN gene transcription;Regulation of the apoptosome activity;Growth hormone receptor signaling |
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1118 5596 MAPK4 False True MAPK6/MAPK4 signaling |
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1119 5598 MAPK7 False True ERK/MAPK targets;ERK/MAPK targets;Signalling to ERK5;Signalling to ERK5;ERKs are inactivated;Senescence-Associated Secretory Phenotype (SASP);Gastrin-CREB signalling pathway via PKC and MAPK;RET signaling |
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1120 5599 MAPK8 False True Activation of BIM and translocation to mitochondria ;Activation of BMF and translocation to mitochondria;NRAGE signals death through JNK;NRAGE signals death through JNK;NRIF signals cell death from the nucleus;Oxidative Stress Induced Senescence;FCERI mediated MAPK activation;DSCAM interactions;JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1;Activation of the AP-1 family of transcription factors;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Interleukin-38 signaling |
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1121 5602 MAPK10 False True Oxidative Stress Induced Senescence;FCERI mediated MAPK activation;JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1;Activation of the AP-1 family of transcription factors |
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1122 5604 MAP2K1 False True MAPK3 (ERK1) activation;Signal transduction by L1;Uptake and function of anthrax toxins;RAF activation;MAP2K and MAPK activation;Negative feedback regulation of MAPK pathway;MAP3K8 (TPL2)-dependent MAPK1/3 activation;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF |
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1123 5605 MAP2K2 False True MAPK1 (ERK2) activation;Signal transduction by L1;Uptake and function of anthrax toxins;RAF activation;MAP2K and MAPK activation;Negative feedback regulation of MAPK pathway;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF |
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1124 5606 MAP2K3 False True Oxidative Stress Induced Senescence;activated TAK1 mediates p38 MAPK activation;Uptake and function of anthrax toxins |
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1125 5607 MAP2K5 False True Signalling to ERK5 |
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1126 5609 MAP2K7 False True Oxidative Stress Induced Senescence;FCERI mediated MAPK activation;JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1;Uptake and function of anthrax toxins |
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1127 5610 EIF2AK2 False True ISG15 antiviral mechanism;Inhibition of PKR |
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1128 5613 PRKX False True PKA-mediated phosphorylation of CREB;CREB1 phosphorylation through the activation of Adenylate Cyclase |
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1129 5616 PRKY False True NA |
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1130 5621 PRNP False True NCAM1 interactions |
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1131 5630 PRPH False True NA |
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1132 5631 PRPS1 False True 5-Phosphoribose 1-diphosphate biosynthesis |
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1133 5635 PRPSAP1 False True NA |
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1134 5636 PRPSAP2 False True NA |
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1135 5641 LGMN False True Trafficking and processing of endosomal TLR;Vitamin D (calciferol) metabolism;MHC class II antigen presentation |
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1136 5644 PRSS1 False True Activation of Matrix Metalloproteinases;Cobalamin (Cbl, vitamin B12) transport and metabolism |
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1137 5646 PRSS3 False True Alpha-defensins;Cobalamin (Cbl, vitamin B12) transport and metabolism;Neutrophil degranulation;Antimicrobial peptides |
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1138 5660 PSAP False True Platelet degranulation ;Glycosphingolipid metabolism;Peptide ligand-binding receptors;G alpha (i) signalling events;Neutrophil degranulation |
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1139 5663 PSEN1 False True Nuclear signaling by ERBB4;Degradation of the extracellular matrix;Regulated proteolysis of p75NTR;NRIF signals cell death from the nucleus;Activated NOTCH1 Transmits Signal to the Nucleus;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;NOTCH2 Activation and Transmission of Signal to the Nucleus;EPH-ephrin mediated repulsion of cells;Neutrophil degranulation;NOTCH3 Activation and Transmission of Signal to the Nucleus;NOTCH4 Activation and Transmission of Signal to the Nucleus;Noncanonical activation of NOTCH3 |
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1140 5664 PSEN2 False True Nuclear signaling by ERBB4;Regulated proteolysis of p75NTR;NRIF signals cell death from the nucleus;Activated NOTCH1 Transmits Signal to the Nucleus;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;NOTCH2 Activation and Transmission of Signal to the Nucleus;EPH-ephrin mediated repulsion of cells;NOTCH3 Activation and Transmission of Signal to the Nucleus;NOTCH4 Activation and Transmission of Signal to the Nucleus;Noncanonical activation of NOTCH3 |
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1141 5681 PSKH1 False True NA |
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1142 5682 PSMA1 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation |
99f6a94c1ade
planemo upload commit 4ba1ebe7b3f5e3fabf78b5fed7ed0b92e2cbf9e5-dirty
proteore
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1143 5683 PSMA2 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation |
99f6a94c1ade
planemo upload commit 4ba1ebe7b3f5e3fabf78b5fed7ed0b92e2cbf9e5-dirty
proteore
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1144 5684 PSMA3 True True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation |
99f6a94c1ade
planemo upload commit 4ba1ebe7b3f5e3fabf78b5fed7ed0b92e2cbf9e5-dirty
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1145 5685 PSMA4 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation |
99f6a94c1ade
planemo upload commit 4ba1ebe7b3f5e3fabf78b5fed7ed0b92e2cbf9e5-dirty
proteore
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1146 5686 PSMA5 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation |
99f6a94c1ade
planemo upload commit 4ba1ebe7b3f5e3fabf78b5fed7ed0b92e2cbf9e5-dirty
proteore
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1147 5687 PSMA6 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation |
99f6a94c1ade
planemo upload commit 4ba1ebe7b3f5e3fabf78b5fed7ed0b92e2cbf9e5-dirty
proteore
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1148 5688 PSMA7 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation |
99f6a94c1ade
planemo upload commit 4ba1ebe7b3f5e3fabf78b5fed7ed0b92e2cbf9e5-dirty
proteore
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1149 5689 PSMB1 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation |
99f6a94c1ade
planemo upload commit 4ba1ebe7b3f5e3fabf78b5fed7ed0b92e2cbf9e5-dirty
proteore
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1150 5690 PSMB2 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation |
99f6a94c1ade
planemo upload commit 4ba1ebe7b3f5e3fabf78b5fed7ed0b92e2cbf9e5-dirty
proteore
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1151 5691 PSMB3 True True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation |
99f6a94c1ade
planemo upload commit 4ba1ebe7b3f5e3fabf78b5fed7ed0b92e2cbf9e5-dirty
proteore
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1152 5692 PSMB4 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation |
99f6a94c1ade
planemo upload commit 4ba1ebe7b3f5e3fabf78b5fed7ed0b92e2cbf9e5-dirty
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1153 5693 PSMB5 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation |
99f6a94c1ade
planemo upload commit 4ba1ebe7b3f5e3fabf78b5fed7ed0b92e2cbf9e5-dirty
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1154 5694 PSMB6 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation |
99f6a94c1ade
planemo upload commit 4ba1ebe7b3f5e3fabf78b5fed7ed0b92e2cbf9e5-dirty
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1155 5695 PSMB7 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation |
99f6a94c1ade
planemo upload commit 4ba1ebe7b3f5e3fabf78b5fed7ed0b92e2cbf9e5-dirty
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1156 5696 PSMB8 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Interferon alpha/beta signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation |
99f6a94c1ade
planemo upload commit 4ba1ebe7b3f5e3fabf78b5fed7ed0b92e2cbf9e5-dirty
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1157 5698 PSMB9 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation |
99f6a94c1ade
planemo upload commit 4ba1ebe7b3f5e3fabf78b5fed7ed0b92e2cbf9e5-dirty
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1158 5699 PSMB10 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation |
99f6a94c1ade
planemo upload commit 4ba1ebe7b3f5e3fabf78b5fed7ed0b92e2cbf9e5-dirty
proteore
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1159 5700 PSMC1 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;N-glycan trimming in the ER and Calnexin/Calreticulin cycle;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation |
99f6a94c1ade
planemo upload commit 4ba1ebe7b3f5e3fabf78b5fed7ed0b92e2cbf9e5-dirty
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1160 5701 PSMC2 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation |
99f6a94c1ade
planemo upload commit 4ba1ebe7b3f5e3fabf78b5fed7ed0b92e2cbf9e5-dirty
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1161 5702 PSMC3 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation |
99f6a94c1ade
planemo upload commit 4ba1ebe7b3f5e3fabf78b5fed7ed0b92e2cbf9e5-dirty
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1162 5704 PSMC4 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation |
99f6a94c1ade
planemo upload commit 4ba1ebe7b3f5e3fabf78b5fed7ed0b92e2cbf9e5-dirty
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1163 5705 PSMC5 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation |
99f6a94c1ade
planemo upload commit 4ba1ebe7b3f5e3fabf78b5fed7ed0b92e2cbf9e5-dirty
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1164 5706 PSMC6 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation |
99f6a94c1ade
planemo upload commit 4ba1ebe7b3f5e3fabf78b5fed7ed0b92e2cbf9e5-dirty
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1165 5707 PSMD1 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation |
99f6a94c1ade
planemo upload commit 4ba1ebe7b3f5e3fabf78b5fed7ed0b92e2cbf9e5-dirty
proteore
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1166 5708 PSMD2 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation |
99f6a94c1ade
planemo upload commit 4ba1ebe7b3f5e3fabf78b5fed7ed0b92e2cbf9e5-dirty
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1167 5709 PSMD3 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation |
99f6a94c1ade
planemo upload commit 4ba1ebe7b3f5e3fabf78b5fed7ed0b92e2cbf9e5-dirty
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1168 5710 PSMD4 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation |
99f6a94c1ade
planemo upload commit 4ba1ebe7b3f5e3fabf78b5fed7ed0b92e2cbf9e5-dirty
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1169 5711 PSMD5 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation |
99f6a94c1ade
planemo upload commit 4ba1ebe7b3f5e3fabf78b5fed7ed0b92e2cbf9e5-dirty
proteore
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1170 5713 PSMD7 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation |
99f6a94c1ade
planemo upload commit 4ba1ebe7b3f5e3fabf78b5fed7ed0b92e2cbf9e5-dirty
proteore
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1171 5714 PSMD8 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation |
99f6a94c1ade
planemo upload commit 4ba1ebe7b3f5e3fabf78b5fed7ed0b92e2cbf9e5-dirty
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1172 5717 PSMD11 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation |
99f6a94c1ade
planemo upload commit 4ba1ebe7b3f5e3fabf78b5fed7ed0b92e2cbf9e5-dirty
proteore
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1173 5718 PSMD12 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation |
99f6a94c1ade
planemo upload commit 4ba1ebe7b3f5e3fabf78b5fed7ed0b92e2cbf9e5-dirty
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1174 5719 PSMD13 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation |
99f6a94c1ade
planemo upload commit 4ba1ebe7b3f5e3fabf78b5fed7ed0b92e2cbf9e5-dirty
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1175 5720 PSME1 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation |
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1176 5721 PSME2 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation |
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1177 5725 PTBP1 False True FGFR2 alternative splicing;mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA |
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1178 5728 PTEN False True Synthesis of PIPs at the plasma membrane;Synthesis of IP3 and IP4 in the cytosol;Negative regulation of the PI3K/AKT network;Downstream TCR signaling;TP53 Regulates Metabolic Genes;PTEN Loss of Function in Cancer;Ub-specific processing proteases;Ovarian tumor domain proteases;Regulation of PTEN mRNA translation;Regulation of PTEN localization;Regulation of PTEN stability and activity;Transcriptional Regulation by MECP2 |
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1179 5730 PTGDS False True Synthesis of Prostaglandins (PG) and Thromboxanes (TX) |
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1180 5747 PTK2 False True Apoptotic cleavage of cellular proteins;Regulation of actin dynamics for phagocytic cup formation;Integrin alphaIIb beta3 signaling;GRB2:SOS provides linkage to MAPK signaling for Integrins ;p130Cas linkage to MAPK signaling for integrins;NCAM signaling for neurite out-growth;NCAM signaling for neurite out-growth;Signal regulatory protein family interactions;EPHB-mediated forward signaling;EPHB-mediated forward signaling;DCC mediated attractive signaling;DCC mediated attractive signaling;VEGFA-VEGFR2 Pathway;VEGFA-VEGFR2 Pathway;RHO GTPases Activate WASPs and WAVEs;RAF/MAP kinase cascade;MET activates PTK2 signaling |
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1181 5753 PTK6 False True SCF(Skp2)-mediated degradation of p27/p21;Cyclin D associated events in G1;ERBB2 Activates PTK6 Signaling;PTK6 Regulates Proteins Involved in RNA Processing;PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1;PTK6 Regulates Cell Cycle;PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases;PTK6 Down-Regulation;PTK6 Expression;PTK6 Activates STAT3;PTK6 promotes HIF1A stabilization |
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1182 5756 TWF1 False True NA |
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1183 5757 PTMA False True NA |
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1184 5763 PTMS False True NA |
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1185 5764 PTN False True NA |
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1186 5768 QSOX1 False True Platelet degranulation ;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Neutrophil degranulation;Post-translational protein phosphorylation |
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1187 5770 PTPN1 False True Integrin alphaIIb beta3 signaling;Negative regulation of MET activity;Regulation of IFNG signaling;PTK6 Down-Regulation;MECP2 regulates neuronal receptors and channels;Regulation of IFNA signaling;Growth hormone receptor signaling;Growth hormone receptor signaling |
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1188 5771 PTPN2 False True Negative regulation of MET activity;Regulation of IFNG signaling;Interleukin-37 signaling |
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1189 5774 PTPN3 False True EGFR downregulation |
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1190 5777 PTPN6 False True GPVI-mediated activation cascade;Regulation of KIT signaling;PECAM1 interactions;Costimulation by the CD28 family;PD-1 signaling;Signal regulatory protein family interactions;Platelet sensitization by LDL;Interleukin-3, Interleukin-5 and GM-CSF signaling;CD22 mediated BCR regulation;Neutrophil degranulation;Interferon gamma signaling;Regulation of IFNG signaling;Interleukin-37 signaling;Interferon alpha/beta signaling;Interleukin receptor SHC signaling;Regulation of IFNA signaling;Growth hormone receptor signaling;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
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1191 5780 PTPN9 False True Interleukin-37 signaling |
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1192 5782 PTPN12 False True SHC1 events in ERBB2 signaling;SHC1 events in ERBB2 signaling;EGFR downregulation;Signaling by PDGF;Downregulation of ERBB2 signaling;Interleukin-37 signaling |
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1193 5784 PTPN14 False True Interleukin-37 signaling |
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1194 5786 PTPRA False True NCAM signaling for neurite out-growth;NCAM signaling for neurite out-growth;RAF/MAP kinase cascade |
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1195 5793 PTPRG False True NA |
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1196 5814 PURB False True NA |
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1197 5819 PVRL2 False True Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Adherens junctions interactions;Nectin/Necl trans heterodimerization |
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1198 5824 PEX19 False True ABC transporters in lipid homeostasis |
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1199 5829 PXN False True GAB1 signalosome;VEGFA-VEGFR2 Pathway;Smooth Muscle Contraction;Localization of the PINCH-ILK-PARVIN complex to focal adhesions;Regulation of cytoskeletal remodeling and cell spreading by IPP complex components;PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases |
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1200 5830 PEX5 False True E3 ubiquitin ligases ubiquitinate target proteins;Peroxisomal protein import;Peroxisomal protein import |
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1201 5859 QARS False True SeMet incorporation into proteins;Cytosolic tRNA aminoacylation;Mitochondrial tRNA aminoacylation |
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1202 5860 QDPR False True Phenylalanine and tyrosine catabolism |
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1203 5861 RAB1A False True Golgi Cisternae Pericentriolar Stack Reorganization;Golgi Cisternae Pericentriolar Stack Reorganization;COPII-mediated vesicle transport;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;RAB geranylgeranylation;RAB GEFs exchange GTP for GDP on RABs |
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1204 5862 RAB2A False True Golgi Cisternae Pericentriolar Stack Reorganization;RAB geranylgeranylation |
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1205 5866 RAB3IL1 False True RAB GEFs exchange GTP for GDP on RABs |
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1206 5867 RAB4A False True Translocation of SLC2A4 (GLUT4) to the plasma membrane;Synthesis of PIPs at the plasma membrane;TBC/RABGAPs;RAB geranylgeranylation;MET receptor recycling |
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1207 5868 RAB5A False True Synthesis of PIPs at the plasma membrane;TBC/RABGAPs;Clathrin-mediated endocytosis;RAB geranylgeranylation;RAB GEFs exchange GTP for GDP on RABs;Factors involved in megakaryocyte development and platelet production |
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1208 5869 RAB5B False True Neutrophil degranulation;TBC/RABGAPs;Clathrin-mediated endocytosis;RAB geranylgeranylation;RAB GEFs exchange GTP for GDP on RABs |
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1209 5871 MAP4K2 False True NA |
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1210 5879 RAC1 False True GPVI-mediated activation cascade;PIP3 activates AKT signaling;Signaling by SCF-KIT;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Nef and signal transduction;NRAGE signals death through JNK;Rho GTPase cycle;Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;Constitutive Signaling by Aberrant PI3K in Cancer;DAP12 signaling;FCERI mediated MAPK activation;DSCAM interactions;CD28 dependent Vav1 pathway;EPHB-mediated forward signaling;Ephrin signaling;EPH-ephrin mediated repulsion of cells;Sema3A PAK dependent Axon repulsion;SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion;PCP/CE pathway;Sema4D mediated inhibition of cell attachment and migration;DCC mediated attractive signaling;DCC mediated attractive signaling;Activation of RAC1;Inactivation of CDC42 and RAC1;VEGFA-VEGFR2 Pathway;Signal transduction by L1;VEGFR2 mediated vascular permeability;RHO GTPases activate PKNs;RHO GTPases activate CIT;RHO GTPases activate CIT;RHO GTPases activate KTN1;RHO GTPases activate IQGAPs;RHO GTPases activate PAKs;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate Formins;RHO GTPases Activate Formins;RHO GTPases Activate NADPH Oxidases;MAPK6/MAPK4 signaling;Neutrophil degranulation;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases;MET activates RAP1 and RAC1;NTRK2 activates RAC1;Activated NTRK2 signals through CDK5;Activation of RAC1 downstream of NMDARs;Factors involved in megakaryocyte development and platelet production |
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1211 5885 RAD21 False True Meiotic synapsis;Separation of Sister Chromatids;Establishment of Sister Chromatid Cohesion;Cohesin Loading onto Chromatin;Resolution of Sister Chromatid Cohesion;SUMOylation of DNA damage response and repair proteins;Estrogen-dependent gene expression |
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1212 5886 RAD23A False True Josephin domain DUBs;DNA Damage Recognition in GG-NER;Formation of Incision Complex in GG-NER |
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1213 5887 RAD23B False True N-glycan trimming in the ER and Calnexin/Calreticulin cycle;Josephin domain DUBs;DNA Damage Recognition in GG-NER;Formation of Incision Complex in GG-NER |
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1214 5892 RAD51D False True HDR through Homologous Recombination (HRR);Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA);Resolution of D-loop Structures through Holliday Junction Intermediates;Homologous DNA Pairing and Strand Exchange;Presynaptic phase of homologous DNA pairing and strand exchange;TP53 Regulates Transcription of DNA Repair Genes |
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1215 5894 RAF1 False True Stimuli-sensing channels;Rap1 signalling;GP1b-IX-V activation signalling;CD209 (DC-SIGN) signaling;RAF activation;MAP2K and MAPK activation;Negative feedback regulation of MAPK pathway;Negative regulation of MAPK pathway;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF |
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1216 5896 RAG1 False True Interleukin-7 signaling;MAPK6/MAPK4 signaling |
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1217 5898 RALA False True Translocation of SLC2A4 (GLUT4) to the plasma membrane;Translocation of SLC2A4 (GLUT4) to the plasma membrane;p38MAPK events;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation |
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1218 5901 RAN False True Rev-mediated nuclear export of HIV RNA;Regulation of cholesterol biosynthesis by SREBP (SREBF);NEP/NS2 Interacts with the Cellular Export Machinery;Nuclear import of Rev protein;MicroRNA (miRNA) biogenesis;Transcriptional regulation by small RNAs;tRNA processing in the nucleus |
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1219 5903 RANBP2 False True ISG15 antiviral mechanism;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Rev-mediated nuclear export of HIV RNA;Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Viral Messenger RNA Synthesis;NEP/NS2 Interacts with the Cellular Export Machinery;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;snRNP Assembly;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;SUMOylation of DNA damage response and repair proteins;SUMOylation of ubiquitinylation proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;SUMOylation of SUMOylation proteins;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins;Transcriptional regulation by small RNAs;RHO GTPases Activate Formins;tRNA processing in the nucleus;Mitotic Prometaphase |
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1220 5905 RANGAP1 False True Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Rev-mediated nuclear export of HIV RNA;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;SUMOylation of DNA replication proteins;RHO GTPases Activate Formins;Mitotic Prometaphase |
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1221 5906 RAP1A False True Frs2-mediated activation;ARMS-mediated activation;ARMS-mediated activation;Integrin alphaIIb beta3 signaling;GRB2:SOS provides linkage to MAPK signaling for Integrins ;p130Cas linkage to MAPK signaling for integrins;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Rap1 signalling;MAP2K and MAPK activation;Neutrophil degranulation;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF;MET activates RAP1 and RAC1 |
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1222 5910 RAP1GDS1 False True NA |
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1223 5913 RAPSN False True NA |
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1224 5914 RARA False True Nuclear Receptor transcription pathway;SUMOylation of intracellular receptors;Signaling by Retinoic Acid;Activation of anterior HOX genes in hindbrain development during early embryogenesis |
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1225 5917 RARS False True SeMet incorporation into proteins;Cytosolic tRNA aminoacylation |
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1226 5920 RARRES3 False True Acyl chain remodelling of PE |
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1227 5925 RB1 False True Inhibition of replication initiation of damaged DNA by RB1/E2F1;Inhibition of replication initiation of damaged DNA by RB1/E2F1;Condensation of Prophase Chromosomes;Formation of Senescence-Associated Heterochromatin Foci (SAHF);Oncogene Induced Senescence;Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes;Cyclin E associated events during G1/S transition ;Cyclin D associated events in G1;Cyclin A:Cdk2-associated events at S phase entry;RUNX2 regulates osteoblast differentiation |
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1228 5928 RBBP4 False True Transcription of E2F targets under negative control by DREAM complex;Transcription of E2F targets under negative control by DREAM complex;Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1;G0 and Early G1;Polo-like kinase mediated events;PRC2 methylates histones and DNA;Oxidative Stress Induced Senescence;HDACs deacetylate histones;PKMTs methylate histone lysines;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;Activation of E2F1 target genes at G1/S;Activation of anterior HOX genes in hindbrain development during early embryogenesis;Deposition of new CENPA-containing nucleosomes at the centromere;Regulation of TP53 Activity through Acetylation;Cyclin E associated events during G1/S transition ;Cyclin A:Cdk2-associated events at S phase entry;RNA Polymerase I Transcription Initiation;Regulation of PTEN gene transcription;Regulation of PTEN gene transcription;Transcriptional Regulation by E2F6 |
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1229 5929 RBBP5 False True Formation of the beta-catenin:TCF transactivating complex;PKMTs methylate histone lysines;Deactivation of the beta-catenin transactivating complex;Activation of anterior HOX genes in hindbrain development during early embryogenesis;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Neddylation |
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1230 5936 RBM4 False True Circadian Clock |
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1231 5937 RBMS1 False True NA |
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1232 5939 RBMS2 False True NA |
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1233 5940 RBMY1A1 False True NA |
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1234 5954 RCN1 False True Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation |
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1235 5955 RCN2 False True NA |
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1236 5962 RDX False True Recycling pathway of L1;Recycling pathway of L1 |
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1237 5970 RELA False True Activation of NF-kappaB in B cells;RIP-mediated NFkB activation via ZBP1;Regulated proteolysis of p75NTR;Downstream TCR signaling;NF-kB is activated and signals survival;Senescence-Associated Secretory Phenotype (SASP);FCERI mediated NF-kB activation;DEx/H-box helicases activate type I IFN and inflammatory cytokines production ;PKMTs methylate histone lysines;Transcriptional regulation of white adipocyte differentiation;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;Interleukin-1 processing;SUMOylation of immune response proteins;IkBA variant leads to EDA-ID;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;CD209 (DC-SIGN) signaling;CLEC7A/inflammasome pathway;The NLRP3 inflammasome;Interleukin-1 signaling;TRAF6 mediated NF-kB activation |
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1238 5976 UPF1 False True Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1239 5979 RET False True RAF/MAP kinase cascade;RET signaling |
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1240 5981 RFC1 False True Translesion synthesis by REV1;Recognition of DNA damage by PCNA-containing replication complex;Translesion Synthesis by POLH;Polymerase switching on the C-strand of the telomere;PCNA-Dependent Long Patch Base Excision Repair;Translesion synthesis by POLK;Translesion synthesis by POLI;Termination of translesion DNA synthesis;HDR through Homologous Recombination (HRR);Gap-filling DNA repair synthesis and ligation in GG-NER;Dual Incision in GG-NER;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Polymerase switching |
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1241 5987 TRIM27 False True SUMOylation of ubiquitinylation proteins;Regulation of PTEN stability and activity |
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1242 5998 RGS3 False True G alpha (q) signalling events;G alpha (i) signalling events |
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1243 6000 RGS7 False True G alpha (i) signalling events;G alpha (i) signalling events;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding |
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1244 6005 RHAG False True Erythrocytes take up carbon dioxide and release oxygen;Erythrocytes take up oxygen and release carbon dioxide;Rhesus glycoproteins mediate ammonium transport.;Defective RHAG causes regulator type Rh-null hemolytic anemia (RHN) |
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1245 6009 RHEB False True Macroautophagy;mTOR signalling;mTORC1-mediated signalling;Energy dependent regulation of mTOR by LKB1-AMPK;TP53 Regulates Metabolic Genes;Regulation of PTEN gene transcription |
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1246 6018 NA False True NA |
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1247 6050 RNH1 False True NA |
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1248 6059 ABCE1 False True OAS antiviral response;Interferon alpha/beta signaling |
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1249 6100 RP9 False True NA |
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1250 6117 RPA1 False True Translesion synthesis by REV1;Recognition of DNA damage by PCNA-containing replication complex;Translesion Synthesis by POLH;Removal of the Flap Intermediate from the C-strand;Activation of ATR in response to replication stress;SUMOylation of DNA damage response and repair proteins;Regulation of HSF1-mediated heat shock response;HSF1 activation;Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha);Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta);Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta);PCNA-Dependent Long Patch Base Excision Repair;Translesion synthesis by POLK;Translesion synthesis by POLI;Termination of translesion DNA synthesis;HDR through Single Strand Annealing (SSA);HDR through Homologous Recombination (HRR);Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;Formation of Incision Complex in GG-NER;Gap-filling DNA repair synthesis and ligation in GG-NER;Dual Incision in GG-NER;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Fanconi Anemia Pathway;Regulation of TP53 Activity through Phosphorylation;Activation of the pre-replicative complex;Removal of the Flap Intermediate;G2/M DNA damage checkpoint;Meiotic recombination |
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1251 6118 RPA2 False True Translesion synthesis by REV1;Recognition of DNA damage by PCNA-containing replication complex;Translesion Synthesis by POLH;Removal of the Flap Intermediate from the C-strand;Activation of ATR in response to replication stress;Regulation of HSF1-mediated heat shock response;HSF1 activation;Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha);Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta);Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta);PCNA-Dependent Long Patch Base Excision Repair;Translesion synthesis by POLK;Translesion synthesis by POLI;Termination of translesion DNA synthesis;HDR through Single Strand Annealing (SSA);HDR through Homologous Recombination (HRR);Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;Formation of Incision Complex in GG-NER;Gap-filling DNA repair synthesis and ligation in GG-NER;Dual Incision in GG-NER;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Fanconi Anemia Pathway;Regulation of TP53 Activity through Phosphorylation;Activation of the pre-replicative complex;Removal of the Flap Intermediate;G2/M DNA damage checkpoint;Meiotic recombination |
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1252 6119 RPA3 False True Translesion synthesis by REV1;Recognition of DNA damage by PCNA-containing replication complex;Translesion Synthesis by POLH;Removal of the Flap Intermediate from the C-strand;Activation of ATR in response to replication stress;Regulation of HSF1-mediated heat shock response;HSF1 activation;Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha);Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta);Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta);PCNA-Dependent Long Patch Base Excision Repair;Translesion synthesis by POLK;Translesion synthesis by POLI;Termination of translesion DNA synthesis;HDR through Single Strand Annealing (SSA);HDR through Homologous Recombination (HRR);Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;Formation of Incision Complex in GG-NER;Gap-filling DNA repair synthesis and ligation in GG-NER;Dual Incision in GG-NER;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Fanconi Anemia Pathway;Regulation of TP53 Activity through Phosphorylation;Activation of the pre-replicative complex;Removal of the Flap Intermediate;G2/M DNA damage checkpoint;Meiotic recombination |
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1253 6120 RPE False True Pentose phosphate pathway |
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1254 6122 RPL3 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1255 6124 RPL4 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1256 6125 RPL5 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1257 6128 RPL6 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1258 6129 RPL7 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1259 6130 RPL7A False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1260 6132 RPL8 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1261 6133 RPL9 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1262 6134 RPL10 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1263 6135 RPL11 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1264 6136 RPL12 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1265 6137 RPL13 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1266 6138 RPL15 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1267 6139 RPL17 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1268 6141 RPL18 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1269 6142 RPL18A False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1270 6143 RPL19 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1271 6144 RPL21 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1272 6146 RPL22 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1273 6147 RPL23A False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1274 6152 RPL24 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1275 6154 RPL26 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1276 6155 RPL27 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1277 6156 RPL30 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1278 6157 RPL27A False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1279 6158 RPL28 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1280 6159 RPL29 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1281 6160 RPL31 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1282 6161 RPL32 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1283 6164 RPL34 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1284 6165 RPL35A False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1285 6167 RPL37 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1286 6168 RPL37A False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1287 6169 RPL38 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1288 6173 RPL36A False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1289 6175 RPLP0 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1290 6176 RPLP1 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1291 6181 RPLP2 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1292 6182 MRPL12 False True Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation elongation;Mitochondrial translation termination |
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1293 6183 MRPS12 False True Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation elongation;Mitochondrial translation termination |
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1294 6184 RPN1 False True SRP-dependent cotranslational protein targeting to membrane;Asparagine N-linked glycosylation |
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1295 6185 RPN2 False True SRP-dependent cotranslational protein targeting to membrane;Asparagine N-linked glycosylation |
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1296 6187 RPS2 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;RMTs methylate histone arginines;rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Protein methylation;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1297 6188 RPS3 True True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1298 6189 RPS3A False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1299 6191 RPS4X False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1300 6193 RPS5 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1301 6194 RPS6 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;mTORC1-mediated signalling;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1302 6195 RPS6KA1 False True ERK/MAPK targets;CREB phosphorylation;Senescence-Associated Secretory Phenotype (SASP);Senescence-Associated Secretory Phenotype (SASP);Recycling pathway of L1;CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling;RSK activation;RSK activation;Gastrin-CREB signalling pathway via PKC and MAPK |
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1303 6196 RPS6KA2 False True ERK/MAPK targets;CREB phosphorylation;Senescence-Associated Secretory Phenotype (SASP);Senescence-Associated Secretory Phenotype (SASP);Recycling pathway of L1;CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling;RSK activation;RSK activation;Gastrin-CREB signalling pathway via PKC and MAPK |
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1304 6197 RPS6KA3 False True ERK/MAPK targets;CREB phosphorylation;Senescence-Associated Secretory Phenotype (SASP);Senescence-Associated Secretory Phenotype (SASP);Recycling pathway of L1;CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling;RSK activation;RSK activation;Gastrin-CREB signalling pathway via PKC and MAPK |
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1305 6198 RPS6KB1 False True mTORC1-mediated signalling |
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1306 6199 RPS6KB2 False True AKT phosphorylates targets in the nucleus;Constitutive Signaling by AKT1 E17K in Cancer |
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1307 6201 RPS7 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1308 6202 RPS8 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1309 6203 RPS9 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1310 6204 RPS10 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1311 6205 RPS11 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1312 6206 RPS12 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1313 6207 RPS13 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1314 6208 RPS14 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1315 6209 RPS15 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1316 6210 RPS15A False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1317 6217 RPS16 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1318 6218 RPS17 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1319 6222 RPS18 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1320 6223 RPS19 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1321 6224 RPS20 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1322 6227 RPS21 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1323 6228 RPS23 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1324 6229 RPS24 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1325 6230 RPS25 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1326 6231 RPS26 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1327 6232 RPS27 False True Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Major pathway of rRNA processing in the nucleolus and cytosol;Mitotic Prometaphase;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1328 6233 RPS27A False True Translesion synthesis by REV1;Recognition of DNA damage by PCNA-containing replication complex;Translesion Synthesis by POLH;Activation of NF-kappaB in B cells;ISG15 antiviral mechanism;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants;ER-Phagosome pathway;Downregulation of ERBB4 signaling;Spry regulation of FGF signaling;Downregulation of ERBB2:ERBB3 signaling;L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;Budding and maturation of HIV virion;NOD1/2 Signaling Pathway;TICAM1, RIP1-mediated IKK complex recruitment ;DDX58/IFIH1-mediated induction of interferon-alpha/beta;APC/C:Cdc20 mediated degradation of Cyclin B;Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Membrane binding and targetting of GAG proteins;Assembly Of The HIV Virion;APC-Cdc20 mediated degradation of Nek2A;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;EGFR downregulation;SCF(Skp2)-mediated degradation of p27/p21;Viral mRNA Translation;Degradation of beta-catenin by the destruction complex;TCF dependent signaling in response to WNT;Downstream TCR signaling;NRIF signals cell death from the nucleus;p75NTR recruits signalling complexes;NF-kB is activated and signals survival;Regulation of activated PAK-2p34 by proteasome mediated degradation;NOTCH1 Intracellular Domain Regulates Transcription;Activated NOTCH1 Transmits Signal to the Nucleus;Activated NOTCH1 Transmits Signal to the Nucleus;Downregulation of TGF-beta receptor signaling;Downregulation of TGF-beta receptor signaling;TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);Downregulation of SMAD2/3:SMAD4 transcriptional activity;Downregulation of SMAD2/3:SMAD4 transcriptional activity;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;Selenocysteine synthesis;Separation of Sister Chromatids;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);Oncogene Induced Senescence;Regulation of PLK1 Activity at G2/M Transition;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Stimuli-sensing channels;Constitutive Signaling by NOTCH1 HD Domain Mutants;FCERI mediated NF-kB activation;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;NOTCH2 Activation and Transmission of Signal to the Nucleus;Regulation of innate immune responses to cytosolic DNA;Glycogen synthesis;Autodegradation of the E3 ubiquitin ligase COP1;Deactivation of the beta-catenin transactivating complex;Myoclonic epilepsy of Lafora;ABC-family proteins mediated transport;Circadian Clock;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;activated TAK1 mediates p38 MAPK activation;JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Regulation of FZD by ubiquitination;Pink/Parkin Mediated Mitophagy;N-glycan trimming in the ER and Calnexin/Calreticulin cycle;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Hedgehog 'on' state;Negative regulation of FGFR1 signaling;Negative regulation of FGFR2 signaling;Negative regulation of FGFR3 signaling;Negative regulation of FGFR4 signaling;Translesion synthesis by POLK;Translesion synthesis by POLI;Termination of translesion DNA synthesis;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;Negative regulation of MAPK pathway;Regulation of necroptotic cell death;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAP3K8 (TPL2)-dependent MAPK1/3 activation;HDR through Homologous Recombination (HRR);MAPK6/MAPK4 signaling;UCH proteinases;UCH proteinases;Josephin domain DUBs;Ub-specific processing proteases;Ovarian tumor domain proteases;Metalloprotease DUBs;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Processing of DNA double-strand break ends;DNA Damage Recognition in GG-NER;Formation of Incision Complex in GG-NER;Gap-filling DNA repair synthesis and ligation in GG-NER;Dual Incision in GG-NER;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Fanconi Anemia Pathway;Major pathway of rRNA processing in the nucleolus and cytosol;Regulation of TP53 Activity through Phosphorylation;Regulation of TP53 Degradation;Regulation of TP53 Activity through Methylation;Negative regulation of MET activity;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;Cyclin D associated events in G1;G2/M Checkpoints;Stabilization of p53;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Downregulation of ERBB2 signaling;Synthesis of active ubiquitin: roles of E1 and E2 enzymes;Synthesis of active ubiquitin: roles of E1 and E2 enzymes;E3 ubiquitin ligases ubiquitinate target proteins;InlB-mediated entry of Listeria monocytogenes into host cell;InlA-mediated entry of Listeria monocytogenes into host cells;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN localization;Regulation of PTEN stability and activity;Neddylation;ER Quality Control Compartment (ERQC);Regulation of expression of SLITs and ROBOs;Regulation of expression of SLITs and ROBOs;NOTCH3 Activation and Transmission of Signal to the Nucleus;NOTCH3 Activation and Transmission of Signal to the Nucleus;TICAM1-dependent activation of IRF3/IRF7;TICAM1,TRAF6-dependent induction of TAK1 complex;Interleukin-1 signaling;Peroxisomal protein import;Peroxisomal protein import;Regulation of signaling by CBL;Endosomal Sorting Complex Required For Transport (ESCRT);Iron uptake and transport;Negative regulators of DDX58/IFIH1 signaling;Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon;IRAK1 recruits IKK complex;IKK complex recruitment mediated by RIP1;IRAK2 mediated activation of TAK1 complex;TRAF6-mediated induction of TAK1 complex within TLR4 complex;Negative regulation of NOTCH4 signaling;TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling;IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation;IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);Amyloid fiber formation;Antigen processing: Ubiquitination & Proteasome degradation |
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1329 6235 RPS29 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1330 6236 RRAD False True NA |
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1331 6240 RRM1 False True Interconversion of nucleotide di- and triphosphates |
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1332 6241 RRM2 False True Interconversion of nucleotide di- and triphosphates;Activation of E2F1 target genes at G1/S;Transcriptional Regulation by E2F6 |
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1333 6248 RSC1A1 False True Organic cation transport;Intestinal hexose absorption |
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1334 6251 RSU1 False True Regulation of cytoskeletal remodeling and cell spreading by IPP complex components |
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1335 6252 RTN1 False True NA |
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1336 6262 RYR2 False True Stimuli-sensing channels;Ion homeostasis |
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1337 6275 S100A4 False True NA |
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1338 6278 S100A7 True True Neutrophil degranulation;Metal sequestration by antimicrobial proteins |
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1339 6281 S100A10 False True Dissolution of Fibrin Clot |
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1340 6282 S100A11 True True Neutrophil degranulation |
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1341 6294 SAFB False True SUMOylation of transcription cofactors |
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1342 6301 SARS False True Selenocysteine synthesis;Cytosolic tRNA aminoacylation |
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1343 6303 SAT1 False True Interconversion of polyamines |
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1344 6305 SBF1 False True Synthesis of PIPs at the ER membrane;RAB GEFs exchange GTP for GDP on RABs |
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1345 6310 ATXN1 False True NA |
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1346 6317 SERPINB3 True True Neutrophil degranulation |
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1347 6318 SERPINB4 True True NA |
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1348 6319 SCD False True Activation of gene expression by SREBF (SREBP);Fatty acyl-CoA biosynthesis |
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1349 6331 SCN5A False True Interaction between L1 and Ankyrins;Phase 0 - rapid depolarisation |
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1350 6340 SCNN1G False True Stimuli-sensing channels |
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1351 6386 SDCBP False True Ephrin signaling;Neurofascin interactions;Neutrophil degranulation |
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1352 6390 SDHB False True Respiratory electron transport;Citric acid cycle (TCA cycle) |
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1353 6396 SEC13 False True ISG15 antiviral mechanism;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Rev-mediated nuclear export of HIV RNA;Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Viral Messenger RNA Synthesis;NEP/NS2 Interacts with the Cellular Export Machinery;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;snRNP Assembly;COPII-mediated vesicle transport;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;SUMOylation of DNA damage response and repair proteins;SUMOylation of ubiquitinylation proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;SUMOylation of SUMOylation proteins;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;Transcriptional regulation by small RNAs;RHO GTPases Activate Formins;tRNA processing in the nucleus;Mitotic Prometaphase;Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
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1354 6399 TRAPPC2 False True COPII-mediated vesicle transport;RAB GEFs exchange GTP for GDP on RABs |
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1355 6400 SEL1L False True Pre-NOTCH Processing in Golgi;ABC-family proteins mediated transport;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Defective CFTR causes cystic fibrosis;ER Quality Control Compartment (ERQC) |
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1356 6418 SET False True Condensation of Prophase Chromosomes;HuR (ELAVL1) binds and stabilizes mRNA |
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1357 6421 SFPQ False True PTK6 Regulates Proteins Involved in RNA Processing |
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1358 6426 SRSF1 False True Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;mRNA 3'-end processing |
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1359 6427 SRSF2 False True Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;mRNA 3'-end processing |
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1360 6428 SRSF3 False True Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing |
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1361 6429 SRSF4 False True Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing |
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1362 6430 SRSF5 False True Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing |
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1363 6431 SRSF6 False True Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;mRNA 3'-end processing |
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1364 6432 SRSF7 False True Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;mRNA 3'-end processing |
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1365 6434 TRA2B False True mRNA Splicing - Major Pathway |
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1366 6440 SFTPC False True Surfactant metabolism;Defective pro-SFTPC causes pulmonary surfactant metabolism dysfunction 2 (SMDP2) and respiratory distress syndrome (RDS);Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5);Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4) |
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1367 6441 SFTPD False True Toll Like Receptor 4 (TLR4) Cascade;Toll Like Receptor TLR1:TLR2 Cascade;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Signal regulatory protein family interactions;Surfactant metabolism;Regulation of TLR by endogenous ligand;Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5);Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4) |
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1368 6446 SGK1 False True Stimuli-sensing channels;Regulation of TP53 Degradation;Transcriptional Regulation by MECP2 |
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1369 6449 SGTA False True NA |
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1370 6450 SH3BGR False True NA |
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1371 6455 SH3GL1 False True EGFR downregulation;Negative regulation of MET activity;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;InlB-mediated entry of Listeria monocytogenes into host cell |
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1372 6456 SH3GL2 False True Retrograde neurotrophin signalling;Retrograde neurotrophin signalling;EGFR downregulation;MHC class II antigen presentation;Lysosome Vesicle Biogenesis;Golgi Associated Vesicle Biogenesis;Recycling pathway of L1;Recycling pathway of L1;Negative regulation of MET activity;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;InlB-mediated entry of Listeria monocytogenes into host cell |
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1373 6472 SHMT2 False True Metabolism of folate and pterines |
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1374 6477 SIAH1 False True Netrin-1 signaling;Amyloid fiber formation;Antigen processing: Ubiquitination & Proteasome degradation |
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1375 6493 SIM2 False True NA |
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1376 6494 SIPA1 False True Rap1 signalling |
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1377 6500 SKP1 False True Activation of NF-kappaB in B cells;Prolactin receptor signaling;SCF-beta-TrCP mediated degradation of Emi1;Vpu mediated degradation of CD4;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;NOTCH1 Intracellular Domain Regulates Transcription;Regulation of PLK1 Activity at G2/M Transition;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling;FCERI mediated NF-kB activation;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Circadian Clock;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;NIK-->noncanonical NF-kB signaling;MAP3K8 (TPL2)-dependent MAPK1/3 activation;Orc1 removal from chromatin;Cyclin D associated events in G1;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Neddylation;Interleukin-1 signaling;Iron uptake and transport;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation |
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1378 6502 SKP2 False True APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;SCF(Skp2)-mediated degradation of p27/p21;Ub-specific processing proteases;Orc1 removal from chromatin;Cyclin D associated events in G1;Regulation of RUNX2 expression and activity;Neddylation;Antigen processing: Ubiquitination & Proteasome degradation |
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1379 6505 SLC1A1 False True Glutamate Neurotransmitter Release Cycle;Transport of inorganic cations/anions and amino acids/oligopeptides;Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA) |
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1380 6510 SLC1A5 False True Amino acid transport across the plasma membrane |
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1381 6518 SLC2A5 False True Neutrophil degranulation;Intestinal hexose absorption |
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1382 6520 SLC3A2 False True Basigin interactions;Amino acid transport across the plasma membrane;Tryptophan catabolism |
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1383 6531 SLC6A3 False True Dopamine clearance from the synaptic cleft;Na+/Cl- dependent neurotransmitter transporters;Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS);Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) |
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1384 6541 SLC7A1 False True Amino acid transport across the plasma membrane |
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1385 6548 SLC9A1 False True Hyaluronan uptake and degradation;Sodium/Proton exchangers |
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1386 6586 NA False True Netrin-1 signaling;Signaling by ROBO receptors;Signaling by ROBO receptors;Regulation of commissural axon pathfinding by SLIT and ROBO |
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1387 6588 SLN False True Ion homeostasis;Ion transport by P-type ATPases |
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1388 6595 SMARCA2 False True RMTs methylate histone arginines;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known |
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1389 6597 SMARCA4 False True Interleukin-7 signaling;Formation of the beta-catenin:TCF transactivating complex;RMTs methylate histone arginines;Chromatin modifying enzymes;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known |
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1390 6602 SMARCD1 False True RMTs methylate histone arginines;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known |
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1391 6605 SMARCE1 False True RMTs methylate histone arginines;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known |
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1392 6606 SMN1 False True snRNP Assembly |
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1393 6612 SUMO3 False True SUMO is conjugated to E1 (UBA2:SAE1);SUMO is transferred from E1 to E2 (UBE2I, UBC9);SUMO is proteolytically processed;SUMOylation of DNA damage response and repair proteins;SUMOylation of transcription factors;SUMOylation of transcription cofactors;SUMOylation of intracellular receptors;SUMOylation of intracellular receptors;SUMOylation of chromatin organization proteins;SUMOylation of DNA replication proteins;SUMOylation of immune response proteins;Formation of Incision Complex in GG-NER |
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1394 6613 SUMO2 False True Vitamin D (calciferol) metabolism;SUMO is conjugated to E1 (UBA2:SAE1);SUMO is transferred from E1 to E2 (UBE2I, UBC9);SUMO is proteolytically processed;SUMOylation of DNA damage response and repair proteins;SUMOylation of transcription factors;SUMOylation of transcription cofactors;SUMOylation of SUMOylation proteins;SUMOylation of intracellular receptors;SUMOylation of intracellular receptors;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;Processing of DNA double-strand break ends;Formation of Incision Complex in GG-NER |
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1395 6617 SNAPC1 False True RNA polymerase II transcribes snRNA genes;RNA polymerase II transcribes snRNA genes;RNA Polymerase III Abortive And Retractive Initiation;RNA Polymerase III Transcription Initiation From Type 3 Promoter;RNA Polymerase III Transcription Initiation From Type 3 Promoter |
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1396 6620 SNCB False True MTF1 activates gene expression |
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1397 6622 SNCA False True Amyloid fiber formation |
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1398 6625 SNRNP70 False True mRNA Splicing - Major Pathway |
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1399 6626 SNRPA False True mRNA Splicing - Major Pathway |
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1400 6627 SNRPA1 False True mRNA Splicing - Major Pathway;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation |
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1401 6628 SNRPB False True Cleavage of Growing Transcript in the Termination Region ;SLBP independent Processing of Histone Pre-mRNAs;snRNP Assembly;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |
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1402 6631 SNRPC False True mRNA Splicing - Major Pathway |
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1403 6632 SNRPD1 False True snRNP Assembly;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway |
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1404 6633 SNRPD2 False True snRNP Assembly;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway |
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1405 6634 SNRPD3 False True Cleavage of Growing Transcript in the Termination Region ;SLBP independent Processing of Histone Pre-mRNAs;snRNP Assembly;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |
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1406 6636 SNRPF False True Cleavage of Growing Transcript in the Termination Region ;SLBP independent Processing of Histone Pre-mRNAs;snRNP Assembly;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |
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1407 6638 SNRPN False True mRNA Splicing - Major Pathway |
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1408 6647 SOD1 True True Platelet degranulation ;Detoxification of Reactive Oxygen Species;Detoxification of Reactive Oxygen Species;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation |
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1409 6648 SOD2 False True Transcriptional activation of mitochondrial biogenesis;Detoxification of Reactive Oxygen Species;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes |
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1410 6651 SON False True NA |
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1411 6652 SORD False True Fructose biosynthesis;Formation of xylulose-5-phosphate |
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1412 6667 SP1 False True PPARA activates gene expression;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;Activation of gene expression by SREBF (SREBP);Oncogene Induced Senescence;RNA polymerase II transcribes snRNA genes;RNA polymerase II transcribes snRNA genes;Estrogen-dependent gene expression |
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1413 6675 UAP1 False True Synthesis of UDP-N-acetyl-glucosamine |
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1414 6683 SPAST False True NA |
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1415 6693 SPN False True Cell surface interactions at the vascular wall;Basigin interactions |
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1416 6697 SPR False True Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation;eNOS activation |
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1417 6699 NA True False Formation of the cornified envelope |
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1418 6704 NA True False Formation of the cornified envelope |
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1419 6708 SPTA1 False True NCAM signaling for neurite out-growth;NCAM signaling for neurite out-growth;Interaction between L1 and Ankyrins;Interaction between L1 and Ankyrins;RAF/MAP kinase cascade;COPI-mediated anterograde transport |
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1420 6709 SPTAN1 False True Caspase-mediated cleavage of cytoskeletal proteins;Nephrin family interactions;NCAM signaling for neurite out-growth;NCAM signaling for neurite out-growth;Interaction between L1 and Ankyrins;Interaction between L1 and Ankyrins;RAF/MAP kinase cascade;Neutrophil degranulation;COPI-mediated anterograde transport |
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1421 6711 SPTBN1 False True Nephrin family interactions;NCAM signaling for neurite out-growth;NCAM signaling for neurite out-growth;Interaction between L1 and Ankyrins;Interaction between L1 and Ankyrins;RAF/MAP kinase cascade;COPI-mediated anterograde transport |
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1422 6712 SPTBN2 False True MHC class II antigen presentation;NCAM signaling for neurite out-growth;NCAM signaling for neurite out-growth;Interaction between L1 and Ankyrins;Interaction between L1 and Ankyrins;RAF/MAP kinase cascade;COPI-mediated anterograde transport |
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1423 6713 SQLE False True Cholesterol biosynthesis;Activation of gene expression by SREBF (SREBP) |
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1424 6714 SRC False True Signaling by ERBB2;Nuclear signaling by ERBB4;PIP3 activates AKT signaling;Spry regulation of FGF signaling;Signaling by SCF-KIT;Signaling by SCF-KIT;Regulation of KIT signaling;p38MAPK events;Signaling by EGFR;GAB1 signalosome;Downstream signal transduction;c-src mediated regulation of Cx43 function and closure of gap junctions;FCGR activation;PECAM1 interactions;Constitutive Signaling by Aberrant PI3K in Cancer;EPH-Ephrin signaling;Integrin alphaIIb beta3 signaling;GRB2:SOS provides linkage to MAPK signaling for Integrins ;p130Cas linkage to MAPK signaling for integrins;NCAM signaling for neurite out-growth;CD28 co-stimulation;CTLA4 inhibitory signaling;Signal regulatory protein family interactions;EPHB-mediated forward signaling;EPHB-mediated forward signaling;EPHA-mediated growth cone collapse;EPHA-mediated growth cone collapse;Ephrin signaling;Ephrin signaling;EPH-ephrin mediated repulsion of cells;G alpha (s) signalling events;ADP signalling through P2Y purinoceptor 1;G alpha (i) signalling events;DCC mediated attractive signaling;DCC mediated attractive signaling;Netrin mediated repulsion signals;Regulation of commissural axon pathfinding by SLIT and ROBO;GP1b-IX-V activation signalling;Recycling pathway of L1;VEGFA-VEGFR2 Pathway;VEGFA-VEGFR2 Pathway;Thrombin signalling through proteinase activated receptors (PARs);VEGFR2 mediated cell proliferation;CLEC7A (Dectin-1) signaling;RHO GTPases Activate Formins;RAF activation;MAP2K and MAPK activation;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Cyclin D associated events in G1;RET signaling;MET activates PTK2 signaling;InlA-mediated entry of Listeria monocytogenes into host cells;Regulation of RUNX1 Expression and Activity;Receptor Mediated Mitophagy;RUNX2 regulates osteoblast differentiation;Regulation of RUNX3 expression and activity;Activated NTRK2 signals through FYN;Activated NTRK3 signals through PI3K;Activated NTRK3 signals through PI3K;Long-term potentiation |
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1425 6717 SRI False True Stimuli-sensing channels;Reduction of cytosolic Ca++ levels;Sodium/Calcium exchangers;Ion homeostasis;Ion transport by P-type ATPases |
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1426 6720 SREBF1 False True RORA activates gene expression;Regulation of cholesterol biosynthesis by SREBP (SREBF);Regulation of cholesterol biosynthesis by SREBP (SREBF);PPARA activates gene expression;Activation of gene expression by SREBF (SREBP);Activation of gene expression by SREBF (SREBP);Transcriptional regulation of white adipocyte differentiation;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes |
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1427 6726 SRP9 False True SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane |
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1428 6727 SRP14 False True SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Neutrophil degranulation |
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1429 6728 SRP19 False True SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane |
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1430 6729 SRP54 False True SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane |
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1431 6731 SRP72 False True SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane |
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1432 6732 SRPK1 False True NA |
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1433 6737 TRIM21 False True STING mediated induction of host immune responses;Regulation of innate immune responses to cytosolic DNA;Interferon gamma signaling;Antigen processing: Ubiquitination & Proteasome degradation |
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1434 6741 SSB False True RNA Polymerase III Transcription Termination;RNA Polymerase III Abortive And Retractive Initiation |
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1435 6742 SSBP1 False True Transcriptional activation of mitochondrial biogenesis |
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1436 6744 SSFA2 False True NA |
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1437 6747 SSR3 False True SRP-dependent cotranslational protein targeting to membrane |
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1438 6748 SSR4 False True SRP-dependent cotranslational protein targeting to membrane |
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1439 6749 SSRP1 False True Formation of RNA Pol II elongation complex ;Formation of HIV elongation complex in the absence of HIV Tat;Formation of HIV-1 elongation complex containing HIV-1 Tat;Pausing and recovery of Tat-mediated HIV elongation;Tat-mediated HIV elongation arrest and recovery;Tat-mediated elongation of the HIV-1 transcript;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;RNA Polymerase II Pre-transcription Events;TP53 Regulates Transcription of DNA Repair Genes;Regulation of TP53 Activity through Phosphorylation;RNA Polymerase II Transcription Elongation |
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1440 6764 ST5 False True RAB GEFs exchange GTP for GDP on RABs |
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1441 6767 ST13 False True Regulation of HSF1-mediated heat shock response |
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1442 6769 STAC False True NA |
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1443 6772 STAT1 False True Interleukin-6 signaling;ISG15 antiviral mechanism;Signaling by SCF-KIT;Signaling by cytosolic FGFR1 fusion mutants;Downstream signal transduction;Interleukin-4 and Interleukin-13 signaling;Interferon gamma signaling;Regulation of IFNG signaling;Interleukin-20 family signaling;Regulation of RUNX2 expression and activity;Interleukin-35 Signalling;Interleukin-9 signaling;NOTCH3 Intracellular Domain Regulates Transcription;NOTCH3 Intracellular Domain Regulates Transcription;Interleukin-27 signaling;Interleukin-21 signaling;Interferon alpha/beta signaling;Regulation of IFNA signaling;Growth hormone receptor signaling |
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1444 6773 STAT2 False True Interleukin-20 family signaling;Interferon alpha/beta signaling;Regulation of IFNA signaling;Regulation of IFNA signaling |
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1445 6774 STAT3 False True Interleukin-6 signaling;BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members;Interleukin-7 signaling;Interleukin-7 signaling;Signaling by SCF-KIT;Signaling by cytosolic FGFR1 fusion mutants;Downstream signal transduction;Signalling to STAT3;Senescence-Associated Secretory Phenotype (SASP);Signaling by Leptin;POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation;Association of TriC/CCT with target proteins during biosynthesis;Transcriptional regulation of pluripotent stem cells;Interleukin-10 signaling;Interleukin-4 and Interleukin-13 signaling;PTK6 Activates STAT3;PTK6 Activates STAT3;Interleukin-20 family signaling;MET activates STAT3;MET activates STAT3;Interleukin-15 signaling;Interleukin-35 Signalling;Interleukin-9 signaling;Interleukin-37 signaling;Interleukin-23 signaling;Interleukin-23 signaling;Interleukin-27 signaling;Interleukin-21 signaling;Growth hormone receptor signaling |
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1446 6778 STAT6 False True Downstream signal transduction;STAT6-mediated induction of chemokines;Interleukin-4 and Interleukin-13 signaling |
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1447 6779 NA False True NA |
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1448 6780 STAU1 False True NA |
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1449 6785 ELOVL4 False True Synthesis of very long-chain fatty acyl-CoAs |
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1450 6786 STIM1 False True Elevation of cytosolic Ca2+ levels;Ion homeostasis;Ion homeostasis;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
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1451 6793 STK10 False True Neutrophil degranulation |
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1452 6794 STK11 False True AMPK inhibits chREBP transcriptional activation activity;Energy dependent regulation of mTOR by LKB1-AMPK;Regulation of TP53 Activity through Phosphorylation;FOXO-mediated transcription of cell death genes |
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1453 6795 AURKC False True NA |
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1454 6801 STRN False True NA |
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1455 6809 STX3 False True Other interleukin signaling |
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1456 6810 STX4 False True Disinhibition of SNARE formation;ER-Phagosome pathway;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Clathrin derived vesicle budding;Other interleukin signaling |
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1457 6811 STX5 False True COPII-mediated vesicle transport;Cargo concentration in the ER;COPI-mediated anterograde transport;Intra-Golgi traffic |
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1458 6812 STXBP1 False True Serotonin Neurotransmitter Release Cycle;Norepinephrine Neurotransmitter Release Cycle;Glutamate Neurotransmitter Release Cycle;Dopamine Neurotransmitter Release Cycle;Acetylcholine Neurotransmitter Release Cycle;Regulation of insulin secretion;Neurexins and neuroligins;GABA synthesis, release, reuptake and degradation |
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1459 6813 STXBP2 False True Platelet degranulation ;Other interleukin signaling |
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1460 6829 SUPT5H False True Formation of RNA Pol II elongation complex ;Formation of the Early Elongation Complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of the HIV-1 Early Elongation Complex;RNA Pol II CTD phosphorylation and interaction with CE during HIV infection;Formation of HIV-1 elongation complex containing HIV-1 Tat;Formation of HIV-1 elongation complex containing HIV-1 Tat;Pausing and recovery of Tat-mediated HIV elongation;Abortive elongation of HIV-1 transcript in the absence of Tat;Tat-mediated HIV elongation arrest and recovery;Tat-mediated elongation of the HIV-1 transcript;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;RNA Polymerase II Pre-transcription Events;TP53 Regulates Transcription of DNA Repair Genes;RNA polymerase II transcribes snRNA genes;mRNA Capping;RNA Polymerase II Transcription Elongation;RNA Pol II CTD phosphorylation and interaction with CE |
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1461 6835 SURF2 False True NA |
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1462 6836 SURF4 False True Neutrophil degranulation;COPI-dependent Golgi-to-ER retrograde traffic |
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1463 6840 SVIL False True NA |
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1464 6843 VAMP1 False True Toxicity of botulinum toxin type D (BoNT/D);Toxicity of botulinum toxin type F (BoNT/F);Toxicity of botulinum toxin type G (BoNT/G) |
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1465 6844 VAMP2 False True Translocation of SLC2A4 (GLUT4) to the plasma membrane;Serotonin Neurotransmitter Release Cycle;Norepinephrine Neurotransmitter Release Cycle;Glutamate Neurotransmitter Release Cycle;Dopamine Neurotransmitter Release Cycle;Acetylcholine Neurotransmitter Release Cycle;Insulin processing;Clathrin derived vesicle budding;Regulation of insulin secretion;Lysosome Vesicle Biogenesis;Golgi Associated Vesicle Biogenesis;Other interleukin signaling;Toxicity of botulinum toxin type D (BoNT/D);Toxicity of botulinum toxin type B (BoNT/B);Toxicity of botulinum toxin type F (BoNT/F);Toxicity of tetanus toxin (TeNT);Toxicity of botulinum toxin type G (BoNT/G);Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;GABA synthesis, release, reuptake and degradation |
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1466 6856 SYPL1 False True NA |
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1467 6867 TACC1 False True NA |
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1468 6871 TADA2A False True HATs acetylate histones |
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1469 6873 TAF2 False True HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;RNA Polymerase II Pre-transcription Events;Regulation of TP53 Activity through Phosphorylation;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance |
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1470 6876 TAGLN False True NA |
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1471 6885 MAP3K7 False True Activation of NF-kappaB in B cells;NOD1/2 Signaling Pathway;Downstream TCR signaling;FCERI mediated NF-kB activation;Ca2+ pathway;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;activated TAK1 mediates p38 MAPK activation;JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1;TNFR1-induced NFkappaB signaling pathway;CLEC7A (Dectin-1) signaling;Ub-specific processing proteases;TICAM1,TRAF6-dependent induction of TAK1 complex;Interleukin-1 signaling;IRAK2 mediated activation of TAK1 complex;TRAF6-mediated induction of TAK1 complex within TLR4 complex;IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |
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1472 6888 TALDO1 False True Insulin effects increased synthesis of Xylulose-5-Phosphate;TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P;TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P;Pentose phosphate pathway;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation |
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1473 6890 TAP1 False True ER-Phagosome pathway;ER-Phagosome pathway;Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
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1474 6894 TARBP1 False True NA |
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1475 6895 TARBP2 False True MicroRNA (miRNA) biogenesis;Small interfering RNA (siRNA) biogenesis |
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1476 6897 TARS False True Cytosolic tRNA aminoacylation |
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1477 6902 TBCA False True Post-chaperonin tubulin folding pathway |
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1478 6905 TBCE False True Post-chaperonin tubulin folding pathway |
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1479 6907 TBL1X False True RORA activates gene expression;BMAL1:CLOCK,NPAS2 activates circadian gene expression;PPARA activates gene expression;PPARA activates gene expression;NOTCH1 Intracellular Domain Regulates Transcription;Transcriptional activation of mitochondrial biogenesis;Activation of gene expression by SREBF (SREBP);Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;HDACs deacetylate histones;Transcriptional regulation of white adipocyte differentiation;Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha);Circadian Clock;Loss of MECP2 binding ability to the NCoR/SMRT complex;Regulation of MECP2 expression and activity |
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1480 6908 TBP False True HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;SIRT1 negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;B-WICH complex positively regulates rRNA expression;RNA Polymerase II Pre-transcription Events;Regulation of TP53 Activity through Phosphorylation;RNA polymerase II transcribes snRNA genes;RNA polymerase II transcribes snRNA genes;RNA Polymerase I Transcription Initiation;RNA Polymerase I Transcription Initiation;RNA Polymerase I Promoter Escape;RNA Polymerase II Promoter Escape;RNA Polymerase I Chain Elongation;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase I Transcription Termination;RNA Polymerase III Abortive And Retractive Initiation;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Polymerase III Transcription Initiation From Type 1 Promoter;RNA Polymerase III Transcription Initiation From Type 1 Promoter;RNA Polymerase III Transcription Initiation From Type 2 Promoter;RNA Polymerase III Transcription Initiation From Type 2 Promoter;RNA Polymerase III Transcription Initiation From Type 3 Promoter;RNA Polymerase III Transcription Initiation From Type 3 Promoter;Estrogen-dependent gene expression |
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1481 6919 TCEA2 False True NA |
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1482 6924 TCEB3 False True Formation of RNA Pol II elongation complex ;Formation of HIV elongation complex in the absence of HIV Tat;Formation of HIV-1 elongation complex containing HIV-1 Tat;Pausing and recovery of Tat-mediated HIV elongation;Tat-mediated HIV elongation arrest and recovery;Tat-mediated elongation of the HIV-1 transcript;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;RNA Polymerase II Pre-transcription Events;TP53 Regulates Transcription of DNA Repair Genes;RNA Polymerase II Transcription Elongation |
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1483 6925 TCF4 False True CDO in myogenesis;CDO in myogenesis |
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1484 6934 TCF7L2 False True Formation of the beta-catenin:TCF transactivating complex;Formation of the beta-catenin:TCF transactivating complex;Deactivation of the beta-catenin transactivating complex;Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1);Ca2+ pathway;Binding of TCF/LEF:CTNNB1 to target gene promoters;Repression of WNT target genes;Repression of WNT target genes;TCF7L2 mutants don't bind CTBP;RUNX3 regulates WNT signaling |
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1485 6950 TCP1 False True Prefoldin mediated transfer of substrate to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Folding of actin by CCT/TriC;Association of TriC/CCT with target proteins during biosynthesis;Association of TriC/CCT with target proteins during biosynthesis;BBSome-mediated cargo-targeting to cilium;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation |
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1486 6999 TDO2 False True Tryptophan catabolism |
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1487 7001 PRDX2 False True Detoxification of Reactive Oxygen Species;TP53 Regulates Metabolic Genes;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models |
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1488 7013 TERF1 False True Meiotic synapsis;Packaging Of Telomere Ends;DNA Damage/Telomere Stress Induced Senescence |
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1489 7014 TERF2 False True Meiotic synapsis;Packaging Of Telomere Ends;DNA Damage/Telomere Stress Induced Senescence |
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1490 7015 TERT False True Telomere Extension By Telomerase;Formation of the beta-catenin:TCF transactivating complex |
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1491 7016 TESK1 False True Regulation of cytoskeletal remodeling and cell spreading by IPP complex components |
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1492 7018 TF True True Platelet degranulation ;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Post-translational protein phosphorylation;Iron uptake and transport;Transferrin endocytosis and recycling |
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1493 7026 NR2F2 False True Transcriptional regulation of white adipocyte differentiation |
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1494 7037 TFRC False True Golgi Associated Vesicle Biogenesis;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Transferrin endocytosis and recycling |
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1495 7038 TG False True NA |
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1496 7040 TGFB1 False True Platelet degranulation ;Influenza Virus Induced Apoptosis;Cell surface interactions at the vascular wall;Molecules associated with elastic fibres;Downregulation of TGF-beta receptor signaling;Downregulation of TGF-beta receptor signaling;TGF-beta receptor signaling activates SMADs;TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);Syndecan interactions;ECM proteoglycans;SMAD2/3 Phosphorylation Motif Mutants in Cancer;SMAD2/3 MH2 Domain Mutants in Cancer;TGFBR2 MSI Frameshift Mutants in Cancer;TGFBR2 Kinase Domain Mutants in Cancer;TGFBR1 KD Mutants in Cancer;TGFBR1 LBD Mutants in Cancer;Transcriptional regulation of white adipocyte differentiation;UCH proteinases;Interleukin-4 and Interleukin-13 signaling;RUNX3 regulates CDKN1A transcription;Regulation of RUNX3 expression and activity;RUNX3 regulates p14-ARF |
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1497 7041 TGFB1I1 False True NA |
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1498 7046 TGFBR1 False True Downregulation of TGF-beta receptor signaling;Downregulation of TGF-beta receptor signaling;TGF-beta receptor signaling activates SMADs;TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);SMAD2/3 Phosphorylation Motif Mutants in Cancer;SMAD2/3 MH2 Domain Mutants in Cancer;TGFBR2 Kinase Domain Mutants in Cancer;TGFBR1 KD Mutants in Cancer;TGFBR1 LBD Mutants in Cancer;UCH proteinases;Ub-specific processing proteases |
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1499 7048 TGFBR2 False True Downregulation of TGF-beta receptor signaling;Downregulation of TGF-beta receptor signaling;TGF-beta receptor signaling activates SMADs;TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);SMAD2/3 Phosphorylation Motif Mutants in Cancer;SMAD2/3 MH2 Domain Mutants in Cancer;TGFBR2 MSI Frameshift Mutants in Cancer;TGFBR2 Kinase Domain Mutants in Cancer;TGFBR1 KD Mutants in Cancer;TGFBR1 LBD Mutants in Cancer;UCH proteinases |
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1500 7052 TGM2 False True NA |
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1501 7053 TGM3 True True NA |
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1502 7056 THBD False True Common Pathway of Fibrin Clot Formation;Cell surface interactions at the vascular wall |
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1503 7064 THOP1 False True Antigen processing: Ubiquitination & Proteasome degradation |
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1504 7067 THRA False True Nuclear Receptor transcription pathway;SUMOylation of intracellular receptors |
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1505 7073 TIAL1 False True FGFR2 alternative splicing |
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1506 7074 TIAM1 False True NRAGE signals death through JNK;Rho GTPase cycle;EPHB-mediated forward signaling;EPH-ephrin mediated repulsion of cells;G alpha (12/13) signalling events;Activated NTRK2 signals through CDK5 |
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1507 7075 TIE1 False True NA |
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1508 7082 TJP1 False True c-src mediated regulation of Cx43 function and closure of gap junctions;c-src mediated regulation of Cx43 function and closure of gap junctions;Signaling by Hippo;Apoptotic cleavage of cell adhesion proteins;RUNX1 regulates expression of components of tight junctions |
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1509 7086 TKT False True Insulin effects increased synthesis of Xylulose-5-Phosphate;Pentose phosphate pathway |
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1510 7094 TLN1 False True Platelet degranulation ;Integrin alphaIIb beta3 signaling;GRB2:SOS provides linkage to MAPK signaling for Integrins ;p130Cas linkage to MAPK signaling for integrins;XBP1(S) activates chaperone genes;SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion;Smooth Muscle Contraction;MAP2K and MAPK activation;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF |
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1511 7102 NA False True Cell surface interactions at the vascular wall;Trafficking of GluR2-containing AMPA receptors |
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1512 7105 TSPAN6 False True NA |
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1513 7111 TMOD1 False True Striated Muscle Contraction |
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1514 7112 TMPO False True Clearance of Nuclear Envelope Membranes from Chromatin;Initiation of Nuclear Envelope Reformation;Depolymerisation of the Nuclear Lamina |
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1515 7114 TMSB4X False True Platelet degranulation |
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1516 7124 TNF False True Transcriptional regulation of white adipocyte differentiation;TNFR1-induced proapoptotic signaling;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;TNFR1-mediated ceramide production;TNFR2 non-canonical NF-kB pathway;Interleukin-10 signaling;Interleukin-4 and Interleukin-13 signaling;TNF signaling |
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1517 7126 TNFAIP1 False True NA |
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1518 7128 TNFAIP3 False True NOD1/2 Signaling Pathway;TNFR1-induced proapoptotic signaling;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;Ovarian tumor domain proteases;Negative regulators of DDX58/IFIH1 signaling |
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1519 7145 TNS1 False True NA |
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1520 7150 TOP1 False True SUMOylation of DNA replication proteins |
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1521 7153 TOP2A False True Transcription of E2F targets under negative control by DREAM complex;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins |
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1522 7157 TP53 False True Activation of NOXA and translocation to mitochondria;Activation of PUMA and translocation to mitochondria;Pre-NOTCH Transcription and Translation;Oxidative Stress Induced Senescence;Formation of Senescence-Associated Heterochromatin Foci (SAHF);Oncogene Induced Senescence;DNA Damage/Telomere Stress Induced Senescence;SUMOylation of transcription factors;Autodegradation of the E3 ubiquitin ligase COP1;Association of TriC/CCT with target proteins during biosynthesis;TP53 Regulates Metabolic Genes;Ub-specific processing proteases;Ovarian tumor domain proteases;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Interleukin-4 and Interleukin-13 signaling;TP53 Regulates Transcription of DNA Repair Genes;TP53 Regulates Transcription of Genes Involved in Cytochrome C Release;TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain;TP53 Regulates Transcription of Caspase Activators and Caspases;TP53 Regulates Transcription of Death Receptors and Ligands;TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest;TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain;TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest;Regulation of TP53 Expression;Regulation of TP53 Activity through Phosphorylation;Regulation of TP53 Degradation;Regulation of TP53 Activity through Acetylation;Regulation of TP53 Activity through Association with Co-factors;Regulation of TP53 Activity through Methylation;PI5P Regulates TP53 Acetylation;G2/M DNA damage checkpoint;G2/M Checkpoints;Stabilization of p53;Transcriptional activation of cell cycle inhibitor p21 ;The role of GTSE1 in G2/M progression after G2 checkpoint;RUNX3 regulates CDKN1A transcription;Regulation of PTEN gene transcription;Regulation of PTEN gene transcription;Factors involved in megakaryocyte development and platelet production |
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1523 7158 TP53BP1 False True SUMOylation of transcription factors;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Processing of DNA double-strand break ends;G2/M DNA damage checkpoint |
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1524 7159 TP53BP2 False True Activation of PUMA and translocation to mitochondria;TP53 Regulates Transcription of Genes Involved in Cytochrome C Release;TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain;TP53 Regulates Transcription of Death Receptors and Ligands;Regulation of TP53 Activity through Association with Co-factors |
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1525 7163 TPD52 False True Golgi Associated Vesicle Biogenesis |
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1526 7165 TPD52L2 False True NA |
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1527 7167 TPI1 True True Glycolysis;Gluconeogenesis |
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1528 7168 TPM1 False True Striated Muscle Contraction;Smooth Muscle Contraction |
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1529 7169 TPM2 False True Striated Muscle Contraction;Smooth Muscle Contraction |
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1530 7170 TPM3 False True Striated Muscle Contraction;Smooth Muscle Contraction |
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1531 7171 TPM4 False True Striated Muscle Contraction;Smooth Muscle Contraction |
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1532 7175 TPR False True ISG15 antiviral mechanism;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Rev-mediated nuclear export of HIV RNA;Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Viral Messenger RNA Synthesis;NEP/NS2 Interacts with the Cellular Export Machinery;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;snRNP Assembly;SUMOylation of DNA damage response and repair proteins;SUMOylation of ubiquitinylation proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;SUMOylation of SUMOylation proteins;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins;Transcriptional regulation by small RNAs;Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC);tRNA processing in the nucleus |
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1533 7178 TPT1 False True NA |
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1534 7182 NR2C2 False True Nuclear Receptor transcription pathway |
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1535 7184 HSP90B1 False True Trafficking and processing of endosomal TLR;Scavenging by Class A Receptors;Scavenging by Class A Receptors;ATF6 (ATF6-alpha) activates chaperone genes;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Interleukin-4 and Interleukin-13 signaling;Post-translational protein phosphorylation |
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1536 7186 TRAF2 False True Caspase activation via Death Receptors in the presence of ligand;Regulation by c-FLIP;RIPK1-mediated regulated necrosis;CASP8 activity is inhibited;TNFR1-induced proapoptotic signaling;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;TNFR2 non-canonical NF-kB pathway;Regulation of necroptotic cell death;TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway;Ub-specific processing proteases;Dimerization of procaspase-8;TNF signaling;TRAF6 mediated IRF7 activation;TRAF6 mediated NF-kB activation;TRAF6 mediated NF-kB activation |
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1537 7203 CCT3 False True Prefoldin mediated transfer of substrate to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Folding of actin by CCT/TriC;Association of TriC/CCT with target proteins during biosynthesis;Association of TriC/CCT with target proteins during biosynthesis;BBSome-mediated cargo-targeting to cilium;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding |
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1538 7204 TRIO False True NRAGE signals death through JNK;Rho GTPase cycle;G alpha (q) signalling events;G alpha (12/13) signalling events;DCC mediated attractive signaling;DCC mediated attractive signaling |
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1539 7248 TSC1 False True Macroautophagy;Inhibition of TSC complex formation by PKB;Energy dependent regulation of mTOR by LKB1-AMPK;TP53 Regulates Metabolic Genes;TBC/RABGAPs |
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1540 7249 TSC2 False True Macroautophagy;Inhibition of TSC complex formation by PKB;AKT phosphorylates targets in the cytosol;Energy dependent regulation of mTOR by LKB1-AMPK;TP53 Regulates Metabolic Genes;Constitutive Signaling by AKT1 E17K in Cancer;TBC/RABGAPs |
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1541 7251 TSG101 False True Budding and maturation of HIV virion;Membrane binding and targetting of GAG proteins;Endosomal Sorting Complex Required For Transport (ESCRT) |
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1542 7253 TSHR False True Hormone ligand-binding receptors;G alpha (s) signalling events |
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1543 7265 TTC1 False True NA |
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1544 7266 DNAJC7 False True Regulation of HSF1-mediated heat shock response |
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1545 7267 TTC3 False True NA |
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1546 7268 TTC4 False True NA |
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1547 7272 TTK False True NA |
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1548 7273 TTN False True Platelet degranulation ;Striated Muscle Contraction |
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1549 7276 TTR False True Retinoid cycle disease events;The canonical retinoid cycle in rods (twilight vision);Non-integrin membrane-ECM interactions;Neutrophil degranulation;Retinoid metabolism and transport;Amyloid fiber formation |
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1550 7277 TUBA4A False True Platelet degranulation ;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;Gap junction assembly;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;Regulation of PLK1 Activity at G2/M Transition;HSP90 chaperone cycle for steroid hormone receptors (SHR);Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Prefoldin mediated transfer of substrate to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Post-chaperonin tubulin folding pathway;Recycling pathway of L1;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Anchoring of the basal body to the plasma membrane;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;AURKA Activation by TPX2;Carboxyterminal post-translational modifications of tubulin;Carboxyterminal post-translational modifications of tubulin;Activation of AMPK downstream of NMDARs;Kinesins |
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1551 7278 TUBA3C False True Translocation of SLC2A4 (GLUT4) to the plasma membrane;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;Gap junction assembly;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HSP90 chaperone cycle for steroid hormone receptors (SHR);Recruitment of NuMA to mitotic centrosomes;Prefoldin mediated transfer of substrate to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Post-chaperonin tubulin folding pathway;Recycling pathway of L1;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;Carboxyterminal post-translational modifications of tubulin;Carboxyterminal post-translational modifications of tubulin;Activation of AMPK downstream of NMDARs;Kinesins |
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1552 7280 TUBB2A False True Translocation of SLC2A4 (GLUT4) to the plasma membrane;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;Gap junction assembly;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HSP90 chaperone cycle for steroid hormone receptors (SHR);Recruitment of NuMA to mitotic centrosomes;Prefoldin mediated transfer of substrate to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Post-chaperonin tubulin folding pathway;Recycling pathway of L1;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;Carboxyterminal post-translational modifications of tubulin;Carboxyterminal post-translational modifications of tubulin;Activation of AMPK downstream of NMDARs;Kinesins |
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1553 7283 TUBG1 False True Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;AURKA Activation by TPX2 |
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1554 7284 TUFM False True Mitochondrial translation elongation |
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1555 7295 TXN True True Oxidative Stress Induced Senescence;Detoxification of Reactive Oxygen Species;Interconversion of nucleotide di- and triphosphates;TP53 Regulates Metabolic Genes;Protein repair;The NLRP3 inflammasome;The NLRP3 inflammasome;Regulation of FOXO transcriptional activity by acetylation |
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1556 7296 TXNRD1 False True PPARA activates gene expression;Metabolism of ingested H2SeO4 and H2SeO3 into H2Se;Detoxification of Reactive Oxygen Species;Interconversion of nucleotide di- and triphosphates;Metabolism of ingested MeSeO2H into MeSeH;Uptake and function of diphtheria toxin;TP53 Regulates Metabolic Genes |
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1557 7297 TYK2 False True Interleukin-6 signaling;Interleukin-6 signaling;MAPK3 (ERK1) activation;MAPK1 (ERK2) activation;Other interleukin signaling;Interleukin-10 signaling;Interleukin-4 and Interleukin-13 signaling;IL-6-type cytokine receptor ligand interactions;Interleukin-20 family signaling;Interleukin-35 Signalling;Interleukin-12 signaling;Interleukin-12 signaling;Interleukin-23 signaling;Interleukin-23 signaling;Interleukin-27 signaling;Interleukin-27 signaling;Interferon alpha/beta signaling;Regulation of IFNA signaling;Regulation of IFNA signaling |
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1558 7298 TYMS False True Interconversion of nucleotide di- and triphosphates;Activation of E2F1 target genes at G1/S |
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1559 7301 TYRO3 False True NA |
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1560 7307 U2AF1 False True Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing |
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1561 7311 UBA52 True True Translesion synthesis by REV1;Recognition of DNA damage by PCNA-containing replication complex;Translesion Synthesis by POLH;Activation of NF-kappaB in B cells;ISG15 antiviral mechanism;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants;ER-Phagosome pathway;Downregulation of ERBB4 signaling;Spry regulation of FGF signaling;Downregulation of ERBB2:ERBB3 signaling;L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;Budding and maturation of HIV virion;NOD1/2 Signaling Pathway;TICAM1, RIP1-mediated IKK complex recruitment ;DDX58/IFIH1-mediated induction of interferon-alpha/beta;APC/C:Cdc20 mediated degradation of Cyclin B;Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Membrane binding and targetting of GAG proteins;Assembly Of The HIV Virion;APC-Cdc20 mediated degradation of Nek2A;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;EGFR downregulation;SCF(Skp2)-mediated degradation of p27/p21;Viral mRNA Translation;Degradation of beta-catenin by the destruction complex;TCF dependent signaling in response to WNT;Downstream TCR signaling;NRIF signals cell death from the nucleus;p75NTR recruits signalling complexes;NF-kB is activated and signals survival;Regulation of activated PAK-2p34 by proteasome mediated degradation;NOTCH1 Intracellular Domain Regulates Transcription;Activated NOTCH1 Transmits Signal to the Nucleus;Activated NOTCH1 Transmits Signal to the Nucleus;Downregulation of TGF-beta receptor signaling;Downregulation of TGF-beta receptor signaling;TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);Downregulation of SMAD2/3:SMAD4 transcriptional activity;Downregulation of SMAD2/3:SMAD4 transcriptional activity;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;Selenocysteine synthesis;Separation of Sister Chromatids;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);Oncogene Induced Senescence;Regulation of PLK1 Activity at G2/M Transition;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Stimuli-sensing channels;Constitutive Signaling by NOTCH1 HD Domain Mutants;FCERI mediated NF-kB activation;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;NOTCH2 Activation and Transmission of Signal to the Nucleus;Regulation of innate immune responses to cytosolic DNA;Glycogen synthesis;Autodegradation of the E3 ubiquitin ligase COP1;Deactivation of the beta-catenin transactivating complex;Myoclonic epilepsy of Lafora;ABC-family proteins mediated transport;Circadian Clock;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;activated TAK1 mediates p38 MAPK activation;JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Regulation of FZD by ubiquitination;Pink/Parkin Mediated Mitophagy;N-glycan trimming in the ER and Calnexin/Calreticulin cycle;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Hedgehog 'on' state;Negative regulation of FGFR1 signaling;Negative regulation of FGFR2 signaling;Negative regulation of FGFR3 signaling;Negative regulation of FGFR4 signaling;Translesion synthesis by POLK;Translesion synthesis by POLI;Termination of translesion DNA synthesis;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;Negative regulation of MAPK pathway;Regulation of necroptotic cell death;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAP3K8 (TPL2)-dependent MAPK1/3 activation;HDR through Homologous Recombination (HRR);MAPK6/MAPK4 signaling;UCH proteinases;UCH proteinases;Josephin domain DUBs;Ub-specific processing proteases;Ovarian tumor domain proteases;Metalloprotease DUBs;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Processing of DNA double-strand break ends;DNA Damage Recognition in GG-NER;Formation of Incision Complex in GG-NER;Gap-filling DNA repair synthesis and ligation in GG-NER;Dual Incision in GG-NER;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Fanconi Anemia Pathway;Major pathway of rRNA processing in the nucleolus and cytosol;Regulation of TP53 Activity through Phosphorylation;Regulation of TP53 Degradation;Regulation of TP53 Activity through Methylation;Negative regulation of MET activity;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;Cyclin D associated events in G1;G2/M Checkpoints;Stabilization of p53;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Downregulation of ERBB2 signaling;Synthesis of active ubiquitin: roles of E1 and E2 enzymes;Synthesis of active ubiquitin: roles of E1 and E2 enzymes;E3 ubiquitin ligases ubiquitinate target proteins;InlB-mediated entry of Listeria monocytogenes into host cell;InlA-mediated entry of Listeria monocytogenes into host cells;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN localization;Regulation of PTEN stability and activity;Neddylation;ER Quality Control Compartment (ERQC);Regulation of expression of SLITs and ROBOs;Regulation of expression of SLITs and ROBOs;NOTCH3 Activation and Transmission of Signal to the Nucleus;NOTCH3 Activation and Transmission of Signal to the Nucleus;TICAM1-dependent activation of IRF3/IRF7;TICAM1,TRAF6-dependent induction of TAK1 complex;Interleukin-1 signaling;Peroxisomal protein import;Peroxisomal protein import;Regulation of signaling by CBL;Endosomal Sorting Complex Required For Transport (ESCRT);Iron uptake and transport;Negative regulators of DDX58/IFIH1 signaling;Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon;IRAK1 recruits IKK complex;IKK complex recruitment mediated by RIP1;IRAK2 mediated activation of TAK1 complex;TRAF6-mediated induction of TAK1 complex within TLR4 complex;Negative regulation of NOTCH4 signaling;TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling;IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation;IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);Amyloid fiber formation;Antigen processing: Ubiquitination & Proteasome degradation |
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1562 7316 UBC False True Translesion synthesis by REV1;Recognition of DNA damage by PCNA-containing replication complex;Translesion Synthesis by POLH;Activation of NF-kappaB in B cells;ISG15 antiviral mechanism;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants;ER-Phagosome pathway;Downregulation of ERBB4 signaling;Spry regulation of FGF signaling;Downregulation of ERBB2:ERBB3 signaling;Budding and maturation of HIV virion;NOD1/2 Signaling Pathway;TICAM1, RIP1-mediated IKK complex recruitment ;DDX58/IFIH1-mediated induction of interferon-alpha/beta;APC/C:Cdc20 mediated degradation of Cyclin B;Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Membrane binding and targetting of GAG proteins;Assembly Of The HIV Virion;APC-Cdc20 mediated degradation of Nek2A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;EGFR downregulation;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;TCF dependent signaling in response to WNT;Downstream TCR signaling;NRIF signals cell death from the nucleus;p75NTR recruits signalling complexes;NF-kB is activated and signals survival;Regulation of activated PAK-2p34 by proteasome mediated degradation;NOTCH1 Intracellular Domain Regulates Transcription;Activated NOTCH1 Transmits Signal to the Nucleus;Activated NOTCH1 Transmits Signal to the Nucleus;Downregulation of TGF-beta receptor signaling;Downregulation of TGF-beta receptor signaling;TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);Downregulation of SMAD2/3:SMAD4 transcriptional activity;Downregulation of SMAD2/3:SMAD4 transcriptional activity;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;Separation of Sister Chromatids;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);Oncogene Induced Senescence;Regulation of PLK1 Activity at G2/M Transition;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Stimuli-sensing channels;Constitutive Signaling by NOTCH1 HD Domain Mutants;FCERI mediated NF-kB activation;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;NOTCH2 Activation and Transmission of Signal to the Nucleus;Regulation of innate immune responses to cytosolic DNA;Glycogen synthesis;Autodegradation of the E3 ubiquitin ligase COP1;Deactivation of the beta-catenin transactivating complex;Myoclonic epilepsy of Lafora;ABC-family proteins mediated transport;Circadian Clock;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;activated TAK1 mediates p38 MAPK activation;JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Regulation of FZD by ubiquitination;Pink/Parkin Mediated Mitophagy;N-glycan trimming in the ER and Calnexin/Calreticulin cycle;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Hedgehog 'on' state;Negative regulation of FGFR1 signaling;Negative regulation of FGFR2 signaling;Negative regulation of FGFR3 signaling;Negative regulation of FGFR4 signaling;Translesion synthesis by POLK;Translesion synthesis by POLI;Termination of translesion DNA synthesis;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;Negative regulation of MAPK pathway;Regulation of necroptotic cell death;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAP3K8 (TPL2)-dependent MAPK1/3 activation;HDR through Homologous Recombination (HRR);MAPK6/MAPK4 signaling;UCH proteinases;UCH proteinases;Josephin domain DUBs;Ub-specific processing proteases;Ovarian tumor domain proteases;Metalloprotease DUBs;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Processing of DNA double-strand break ends;DNA Damage Recognition in GG-NER;Formation of Incision Complex in GG-NER;Gap-filling DNA repair synthesis and ligation in GG-NER;Dual Incision in GG-NER;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Fanconi Anemia Pathway;Regulation of TP53 Activity through Phosphorylation;Regulation of TP53 Degradation;Regulation of TP53 Activity through Methylation;Negative regulation of MET activity;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;Cyclin D associated events in G1;G2/M Checkpoints;Stabilization of p53;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Downregulation of ERBB2 signaling;Synthesis of active ubiquitin: roles of E1 and E2 enzymes;Synthesis of active ubiquitin: roles of E1 and E2 enzymes;E3 ubiquitin ligases ubiquitinate target proteins;InlB-mediated entry of Listeria monocytogenes into host cell;InlA-mediated entry of Listeria monocytogenes into host cells;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN localization;Regulation of PTEN stability and activity;Neddylation;ER Quality Control Compartment (ERQC);Regulation of expression of SLITs and ROBOs;Regulation of expression of SLITs and ROBOs;NOTCH3 Activation and Transmission of Signal to the Nucleus;NOTCH3 Activation and Transmission of Signal to the Nucleus;TICAM1-dependent activation of IRF3/IRF7;TICAM1,TRAF6-dependent induction of TAK1 complex;Interleukin-1 signaling;Peroxisomal protein import;Peroxisomal protein import;Regulation of signaling by CBL;Endosomal Sorting Complex Required For Transport (ESCRT);Iron uptake and transport;Negative regulators of DDX58/IFIH1 signaling;Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon;IRAK1 recruits IKK complex;IKK complex recruitment mediated by RIP1;IRAK2 mediated activation of TAK1 complex;TRAF6-mediated induction of TAK1 complex within TLR4 complex;Negative regulation of NOTCH4 signaling;TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling;IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation;IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation;Amyloid fiber formation;Antigen processing: Ubiquitination & Proteasome degradation |
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1563 7317 UBA1 False True Synthesis of active ubiquitin: roles of E1 and E2 enzymes;Antigen processing: Ubiquitination & Proteasome degradation |
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1564 7321 UBE2D1 False True Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Inactivation of APC/C via direct inhibition of the APC/C complex;TICAM1, RIP1-mediated IKK complex recruitment ;APC/C:Cdc20 mediated degradation of Cyclin B;Autodegradation of Cdh1 by Cdh1:APC/C;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase;Regulation of APC/C activators between G1/S and early anaphase;APC/C:Cdc20 mediated degradation of mitotic proteins;Phosphorylation of the APC/C;APC-Cdc20 mediated degradation of Nek2A;Signaling by BMP;Downstream TCR signaling;Downregulation of SMAD2/3:SMAD4 transcriptional activity;Separation of Sister Chromatids;Senescence-Associated Secretory Phenotype (SASP);FCERI mediated NF-kB activation;CLEC7A (Dectin-1) signaling;Ovarian tumor domain proteases;CDK-mediated phosphorylation and removal of Cdc6;Synthesis of active ubiquitin: roles of E1 and E2 enzymes;E3 ubiquitin ligases ubiquitinate target proteins;Neddylation;Peroxisomal protein import;Negative regulators of DDX58/IFIH1 signaling;IKK complex recruitment mediated by RIP1;Antigen processing: Ubiquitination & Proteasome degradation |
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1565 7322 UBE2D2 False True Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;TICAM1, RIP1-mediated IKK complex recruitment ;Downstream TCR signaling;FCERI mediated NF-kB activation;CLEC7A (Dectin-1) signaling;Synthesis of active ubiquitin: roles of E1 and E2 enzymes;E3 ubiquitin ligases ubiquitinate target proteins;Neddylation;Peroxisomal protein import;Negative regulators of DDX58/IFIH1 signaling;IKK complex recruitment mediated by RIP1;Antigen processing: Ubiquitination & Proteasome degradation |
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1566 7328 UBE2H False True Synthesis of active ubiquitin: roles of E1 and E2 enzymes;Antigen processing: Ubiquitination & Proteasome degradation |
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1567 7329 UBE2I False True Meiotic synapsis;Vitamin D (calciferol) metabolism;SUMO is transferred from E1 to E2 (UBE2I, UBC9);SUMO is transferred from E1 to E2 (UBE2I, UBC9);SUMOylation of DNA damage response and repair proteins;SUMOylation of transcription factors;SUMOylation of transcription factors;SUMOylation of ubiquitinylation proteins;SUMOylation of transcription cofactors;SUMOylation of transcription cofactors;SUMOylation of SUMOylation proteins;SUMOylation of intracellular receptors;SUMOylation of intracellular receptors;SUMOylation of chromatin organization proteins;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA methylation proteins;SUMOylation of DNA methylation proteins;SUMOylation of immune response proteins;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Processing of DNA double-strand break ends;Formation of Incision Complex in GG-NER;Negative regulation of activity of TFAP2 (AP-2) family transcription factors;Negative regulation of activity of TFAP2 (AP-2) family transcription factors |
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1568 7332 UBE2L3 False True Synthesis of active ubiquitin: roles of E1 and E2 enzymes;E3 ubiquitin ligases ubiquitinate target proteins;Antigen processing: Ubiquitination & Proteasome degradation |
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1569 7334 UBE2N False True ISG15 antiviral mechanism;NOD1/2 Signaling Pathway;TICAM1, RIP1-mediated IKK complex recruitment ;Downstream TCR signaling;FCERI mediated NF-kB activation;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;activated TAK1 mediates p38 MAPK activation;JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1;CLEC7A (Dectin-1) signaling;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Processing of DNA double-strand break ends;Formation of Incision Complex in GG-NER;G2/M DNA damage checkpoint;E3 ubiquitin ligases ubiquitinate target proteins;Interleukin-1 signaling;IRAK1 recruits IKK complex;IKK complex recruitment mediated by RIP1;TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling;IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation;Antigen processing: Ubiquitination & Proteasome degradation |
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1570 7335 UBE2V1 False True NOD1/2 Signaling Pathway;TICAM1, RIP1-mediated IKK complex recruitment ;Downstream TCR signaling;FCERI mediated NF-kB activation;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;activated TAK1 mediates p38 MAPK activation;JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1;CLEC7A (Dectin-1) signaling;Interleukin-1 signaling;IRAK1 recruits IKK complex;IKK complex recruitment mediated by RIP1;TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling;IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation;Antigen processing: Ubiquitination & Proteasome degradation |
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1571 7337 UBE3A False True Antigen processing: Ubiquitination & Proteasome degradation |
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1572 7341 SUMO1 False True SUMO is conjugated to E1 (UBA2:SAE1);SUMO is transferred from E1 to E2 (UBE2I, UBC9);SUMO is proteolytically processed;SUMOylation of DNA damage response and repair proteins;SUMOylation of transcription factors;SUMOylation of transcription factors;SUMOylation of ubiquitinylation proteins;SUMOylation of transcription cofactors;SUMOylation of transcription cofactors;SUMOylation of SUMOylation proteins;SUMOylation of intracellular receptors;SUMOylation of intracellular receptors;SUMOylation of chromatin organization proteins;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA methylation proteins;SUMOylation of DNA methylation proteins;SUMOylation of immune response proteins;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Processing of DNA double-strand break ends;Formation of Incision Complex in GG-NER;G2/M DNA damage checkpoint;Regulation of IFNG signaling;Negative regulation of activity of TFAP2 (AP-2) family transcription factors;Negative regulation of activity of TFAP2 (AP-2) family transcription factors |
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1573 7343 UBTF False True NoRC negatively regulates rRNA expression;RNA Polymerase I Promoter Opening;RNA Polymerase I Transcription Initiation;RNA Polymerase I Promoter Escape;RNA Polymerase I Chain Elongation;RNA Polymerase I Transcription Termination |
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1574 7345 UCHL1 False True UCH proteinases |
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1575 7347 UCHL3 False True UCH proteinases;Synthesis of active ubiquitin: roles of E1 and E2 enzymes;Neddylation |
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1576 7348 UPK1B False True NA |
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1577 7353 UFD1L False True Translesion Synthesis by POLH;Ub-specific processing proteases |
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1578 7358 UGDH False True Formation of the active cofactor, UDP-glucuronate |
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1579 7372 UMPS False True Pyrimidine biosynthesis |
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1580 7374 UNG False True Recognition and association of DNA glycosylase with site containing an affected pyrimidine;Cleavage of the damaged pyrimidine ;Displacement of DNA glycosylase by APEX1 |
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1581 7375 USP4 False True TNFR1-induced proapoptotic signaling;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;Ub-specific processing proteases |
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1582 7381 UQCRB False True Respiratory electron transport |
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1583 7384 UQCRC1 False True Respiratory electron transport |
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1584 7385 UQCRC2 False True Respiratory electron transport |
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1585 7386 UQCRFS1 False True Respiratory electron transport |
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1586 7405 UVRAG False True Macroautophagy |
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1587 7407 VARS False True Cytosolic tRNA aminoacylation |
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1588 7408 VASP False True Generation of second messenger molecules;Signaling by ROBO receptors;Signaling by ROBO receptors;Cell-extracellular matrix interactions |
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1589 7411 VBP1 False True Prefoldin mediated transfer of substrate to CCT/TriC |
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1590 7414 VCL True True Platelet degranulation ;Smooth Muscle Contraction;MAP2K and MAPK activation;Neutrophil degranulation;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF |
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1591 7415 VCP False True Translesion Synthesis by POLH;HSF1 activation;ABC-family proteins mediated transport;N-glycan trimming in the ER and Calnexin/Calreticulin cycle;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Defective CFTR causes cystic fibrosis;Josephin domain DUBs;Ovarian tumor domain proteases;Neutrophil degranulation;E3 ubiquitin ligases ubiquitinate target proteins;Protein methylation |
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1592 7416 VDAC1 False True Mitochondrial protein import;Pink/Parkin Mediated Mitophagy;Ub-specific processing proteases;Pyruvate metabolism;Mitochondrial calcium ion transport |
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1593 7417 VDAC2 False True Ub-specific processing proteases;Mitochondrial calcium ion transport |
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1594 7419 VDAC3 False True Ub-specific processing proteases;Mitochondrial calcium ion transport |
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1595 7421 VDR False True Vitamin D (calciferol) metabolism;Nuclear Receptor transcription pathway;SUMOylation of intracellular receptors |
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1596 7428 VHL False True Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;SUMOylation of ubiquitinylation proteins;Neddylation;Antigen processing: Ubiquitination & Proteasome degradation |
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1597 7430 EZR False True Netrin-1 signaling;Recycling pathway of L1;Recycling pathway of L1 |
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1598 7431 VIM False True Caspase-mediated cleavage of cytoskeletal proteins;Striated Muscle Contraction;Interleukin-4 and Interleukin-13 signaling |
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1599 7443 VRK1 False True Clearance of Nuclear Envelope Membranes from Chromatin;Initiation of Nuclear Envelope Reformation |
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1600 7444 VRK2 False True Clearance of Nuclear Envelope Membranes from Chromatin;Initiation of Nuclear Envelope Reformation |
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1601 7448 VTN False True Molecules associated with elastic fibres;Integrin cell surface interactions;Syndecan interactions;ECM proteoglycans;ECM proteoglycans;Regulation of Complement cascade |
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1602 7453 WARS False True Cytosolic tRNA aminoacylation |
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1603 7458 EIF4H False True L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit |
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1604 7464 CORO2A False True NA |
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1605 7465 WEE1 False True Polo-like kinase mediated events;Cyclin E associated events during G1/S transition ;Cyclin A/B1/B2 associated events during G2/M transition;Cyclin A/B1/B2 associated events during G2/M transition;G2/M DNA replication checkpoint;Cyclin A:Cdk2-associated events at S phase entry;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;Factors involved in megakaryocyte development and platelet production |
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1606 7466 WFS1 False True XBP1(S) activates chaperone genes;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation |
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1607 7514 XPO1 False True Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Rev-mediated nuclear export of HIV RNA;NEP/NS2 Interacts with the Cellular Export Machinery;Downregulation of TGF-beta receptor signaling;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;Deactivation of the beta-catenin transactivating complex;HuR (ELAVL1) binds and stabilizes mRNA;RHO GTPases Activate Formins;MAPK6/MAPK4 signaling;Mitotic Prometaphase;Cyclin A/B1/B2 associated events during G2/M transition |
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1608 7515 XRCC1 False True Resolution of AP sites via the single-nucleotide replacement pathway;APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway;HDR through MMEJ (alt-NHEJ);Gap-filling DNA repair synthesis and ligation in GG-NER;Gap-filling DNA repair synthesis and ligation in TC-NER |
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1609 7517 XRCC3 False True HDR through Homologous Recombination (HRR);Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA);Resolution of D-loop Structures through Holliday Junction Intermediates;Homologous DNA Pairing and Strand Exchange |
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1610 7520 XRCC5 False True 2-LTR circle formation;Cytosolic sensors of pathogen-associated DNA ;IRF3-mediated induction of type I IFN;Nonhomologous End-Joining (NHEJ);Neutrophil degranulation |
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1611 7525 YES1 False True Signaling by ERBB2;Signaling by SCF-KIT;Signaling by SCF-KIT;Regulation of KIT signaling;FCGR activation;PECAM1 interactions;EPH-Ephrin signaling;CD28 co-stimulation;CTLA4 inhibitory signaling;EPHB-mediated forward signaling;EPHB-mediated forward signaling;EPHA-mediated growth cone collapse;EPHA-mediated growth cone collapse;EPH-ephrin mediated repulsion of cells;RUNX2 regulates osteoblast differentiation;Regulation of signaling by CBL;Regulation of signaling by CBL |
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1612 7529 YWHAB False True Activation of BAD and translocation to mitochondria ;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Translocation of SLC2A4 (GLUT4) to the plasma membrane;mTOR signalling;mTORC1-mediated signalling;Frs2-mediated activation;ARMS-mediated activation;Signaling by Hippo;Rap1 signalling;Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA;Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA;RHO GTPases activate PKNs;TP53 Regulates Metabolic Genes;RAF activation;MAP2K and MAPK activation;Negative regulation of MAPK pathway;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;Regulation of localization of FOXO transcription factors |
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1613 7531 YWHAE True True Activation of BAD and translocation to mitochondria ;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Signaling by Hippo;NADE modulates death signalling;Regulation of PLK1 Activity at G2/M Transition;Regulation of HSF1-mediated heat shock response;HSF1 activation;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;RHO GTPases activate PKNs;TP53 Regulates Metabolic Genes;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;AURKA Activation by TPX2;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;RAB GEFs exchange GTP for GDP on RABs |
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1614 7532 YWHAG False True Activation of BAD and translocation to mitochondria ;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;RHO GTPases activate PKNs;TP53 Regulates Metabolic Genes;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;AURKA Activation by TPX2;Regulation of localization of FOXO transcription factors |
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1615 7533 YWHAH False True Activation of BAD and translocation to mitochondria ;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Translocation of SLC2A4 (GLUT4) to the plasma membrane;RHO GTPases activate PKNs;TP53 Regulates Metabolic Genes;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex |
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1616 7534 YWHAZ True True Activation of BAD and translocation to mitochondria ;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Deactivation of the beta-catenin transactivating complex;Rap1 signalling;GP1b-IX-V activation signalling;KSRP (KHSRP) binds and destabilizes mRNA;Interleukin-3, Interleukin-5 and GM-CSF signaling;RHO GTPases activate PKNs;TP53 Regulates Metabolic Genes;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;NOTCH4 Activation and Transmission of Signal to the Nucleus;Negative regulation of NOTCH4 signaling;Regulation of localization of FOXO transcription factors |
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1617 7535 ZAP70 False True Translocation of ZAP-70 to Immunological synapse;Generation of second messenger molecules |
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1618 7536 SF1 False True mRNA Splicing - Major Pathway |
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1619 7542 ZFPL1 False True NA |
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1620 7551 ZNF3 False True Generic Transcription Pathway |
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1621 7597 ZBTB25 False True NA |
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1622 7620 ZNF69 False True NA |
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1623 7625 ZNF74 False True Generic Transcription Pathway |
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1624 7675 NA False True NA |
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1625 7681 MKRN3 False True NA |
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1626 7690 ZNF131 False True SUMOylation of transcription cofactors |
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1627 7697 ZNF138 False True Generic Transcription Pathway |
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1628 7705 NA False True NA |
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1629 7709 ZBTB17 False True XBP1(S) activates chaperone genes |
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1630 7726 TRIM26 False True Interferon gamma signaling |
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1631 7737 RNF113A False True NA |
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1632 7762 NA False True Generic Transcription Pathway |
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1633 7775 ZNF232 False True NA |
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1634 7780 SLC30A2 False True Zinc efflux and compartmentalization by the SLC30 family |
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1635 7781 SLC30A3 False True Zinc efflux and compartmentalization by the SLC30 family |
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1636 7786 MAP3K12 False True NA |
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1637 7791 ZYX False True NA |
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1638 7798 NA False True NA |
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1639 7803 PTP4A1 False True NA |
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1640 7812 CSDE1 False True NA |
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1641 7818 DAP3 False True Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation elongation;Mitochondrial translation termination |
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1642 7846 TUBA1A False True Translocation of SLC2A4 (GLUT4) to the plasma membrane;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;Gap junction assembly;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;Regulation of PLK1 Activity at G2/M Transition;HSP90 chaperone cycle for steroid hormone receptors (SHR);Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Prefoldin mediated transfer of substrate to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Post-chaperonin tubulin folding pathway;Recycling pathway of L1;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Anchoring of the basal body to the plasma membrane;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;AURKA Activation by TPX2;Carboxyterminal post-translational modifications of tubulin;Carboxyterminal post-translational modifications of tubulin;Activation of AMPK downstream of NMDARs;Kinesins |
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1643 7851 MALL False True NA |
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1644 7866 IFRD2 False True NA |
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1645 7867 MAPKAPK3 False True p38MAPK events;Oxidative Stress Induced Senescence;VEGFA-VEGFR2 Pathway;activated TAK1 mediates p38 MAPK activation |
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1646 7871 SLMAP False True NA |
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1647 7874 USP7 False True Ub-specific processing proteases;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Regulation of TP53 Degradation;Synthesis of active ubiquitin: roles of E1 and E2 enzymes;Regulation of PTEN localization |
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1648 7879 RAB7A False True MHC class II antigen presentation;Neutrophil degranulation;TBC/RABGAPs;RAB geranylgeranylation;RAB GEFs exchange GTP for GDP on RABs |
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1649 7913 DEK False True B-WICH complex positively regulates rRNA expression;Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors |
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1650 7915 ALDH5A1 False True Degradation of GABA |
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1651 7916 PRRC2A False True NA |
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1652 7917 BAG6 False True NA |
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1653 7919 DDX39B False True Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA 3'-end processing |
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1654 7936 NELFE False True Formation of RNA Pol II elongation complex ;Formation of the Early Elongation Complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of the HIV-1 Early Elongation Complex;Formation of HIV-1 elongation complex containing HIV-1 Tat;Formation of HIV-1 elongation complex containing HIV-1 Tat;Pausing and recovery of Tat-mediated HIV elongation;Abortive elongation of HIV-1 transcript in the absence of Tat;Tat-mediated HIV elongation arrest and recovery;Tat-mediated elongation of the HIV-1 transcript;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;RNA Polymerase II Pre-transcription Events;TP53 Regulates Transcription of DNA Repair Genes;RNA Polymerase II Transcription Elongation |
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1655 7957 EPM2A False True Glycogen synthesis;Myoclonic epilepsy of Lafora |
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1656 7984 ARHGEF5 False True NRAGE signals death through JNK;Rho GTPase cycle;G alpha (12/13) signalling events |
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1657 8021 NUP214 False True ISG15 antiviral mechanism;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Rev-mediated nuclear export of HIV RNA;Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Viral Messenger RNA Synthesis;NEP/NS2 Interacts with the Cellular Export Machinery;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;snRNP Assembly;SUMOylation of DNA damage response and repair proteins;SUMOylation of ubiquitinylation proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;SUMOylation of SUMOylation proteins;HuR (ELAVL1) binds and stabilizes mRNA;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins;Transcriptional regulation by small RNAs;tRNA processing in the nucleus |
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1658 8027 STAM False True EGFR downregulation;Metalloprotease DUBs;Negative regulation of MET activity;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;InlB-mediated entry of Listeria monocytogenes into host cell;Endosomal Sorting Complex Required For Transport (ESCRT) |
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1659 8078 USP5 False True Ub-specific processing proteases;Synthesis of active ubiquitin: roles of E1 and E2 enzymes |
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1660 8079 MLF2 False True NA |
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1661 8086 AAAS False True ISG15 antiviral mechanism;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Rev-mediated nuclear export of HIV RNA;Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Viral Messenger RNA Synthesis;NEP/NS2 Interacts with the Cellular Export Machinery;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;snRNP Assembly;SUMOylation of DNA damage response and repair proteins;SUMOylation of ubiquitinylation proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;SUMOylation of SUMOylation proteins;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins;Transcriptional regulation by small RNAs;tRNA processing in the nucleus |
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1662 8087 FXR1 False True Signaling by BRAF and RAF fusions |
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1663 8106 PABPN1 False True Cleavage of Growing Transcript in the Termination Region ;Inhibition of Host mRNA Processing and RNA Silencing;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Processing of Intronless Pre-mRNAs |
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1664 8125 ANP32A False True HuR (ELAVL1) binds and stabilizes mRNA |
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1665 8131 NPRL3 False True NA |
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1666 8139 GAN False True Neddylation;Antigen processing: Ubiquitination & Proteasome degradation |
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1667 8148 TAF15 False True HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;RNA Polymerase II Pre-transcription Events;Regulation of TP53 Activity through Phosphorylation;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance |
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1668 8175 SF3A2 False True mRNA Splicing - Major Pathway |
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1669 8187 ZNF239 False True NA |
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1670 8189 SYMPK False True Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA Derived from an Intronless Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Processing of Intronless Pre-mRNAs |
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1671 8195 MKKS False True BBSome-mediated cargo-targeting to cilium |
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1672 8202 NCOA3 False True PPARA activates gene expression;Transcriptional regulation of white adipocyte differentiation;Transcriptional regulation of white adipocyte differentiation;Activation of anterior HOX genes in hindbrain development during early embryogenesis;MAPK6/MAPK4 signaling;Estrogen-dependent gene expression |
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1673 8218 CLTCL1 False True Gap junction degradation;Formation of annular gap junctions;EPH-ephrin mediated repulsion of cells;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis |
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1674 8220 DGCR14 False True NA |
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1675 8239 USP9X False True Downregulation of SMAD2/3:SMAD4 transcriptional activity;Ub-specific processing proteases;Synthesis of active ubiquitin: roles of E1 and E2 enzymes;Peroxisomal protein import;Peroxisomal protein import;Amyloid fiber formation |
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1676 8241 RBM10 False True NA |
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1677 8243 SMC1A False True Meiotic synapsis;Separation of Sister Chromatids;Establishment of Sister Chromatid Cohesion;Cohesin Loading onto Chromatin;Resolution of Sister Chromatid Cohesion;SUMOylation of DNA damage response and repair proteins;Estrogen-dependent gene expression |
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1678 8266 UBL4A False True NA |
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1679 8270 LAGE3 False True tRNA modification in the nucleus and cytosol |
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1680 8294 HIST1H4I False True Meiotic synapsis;Packaging Of Telomere Ends;Pre-NOTCH Transcription and Translation;Formation of the beta-catenin:TCF transactivating complex;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;HDACs deacetylate histones;PKMTs methylate histone lysines;HDMs demethylate histones;HATs acetylate histones;HATs acetylate histones;RMTs methylate histone arginines;SIRT1 negatively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;NoRC negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;SUMOylation of chromatin organization proteins;B-WICH complex positively regulates rRNA expression;DNA methylation;Transcriptional regulation by small RNAs;Activation of anterior HOX genes in hindbrain development during early embryogenesis;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Processing of DNA double-strand break ends;Deposition of new CENPA-containing nucleosomes at the centromere;G2/M DNA damage checkpoint;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Estrogen-dependent gene expression;Meiotic recombination;Amyloid fiber formation |
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1681 8301 PICALM False True Golgi Associated Vesicle Biogenesis;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis |
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1682 8315 BRAP False True RAF activation;Negative regulation of MAPK pathway;Signaling by moderate kinase activity BRAF mutants;Signaling by RAS mutants;Paradoxical activation of RAF signaling by kinase inactive BRAF |
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1683 8318 CDC45 False True Activation of ATR in response to replication stress;Unwinding of DNA;Activation of E2F1 target genes at G1/S;Activation of the pre-replicative complex |
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1684 8324 FZD7 False True Class B/2 (Secretin family receptors);PCP/CE pathway;PCP/CE pathway;Asymmetric localization of PCP proteins |
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1685 8335 HIST1H2AB False True Meiotic synapsis;Packaging Of Telomere Ends;Pre-NOTCH Transcription and Translation;Formation of the beta-catenin:TCF transactivating complex;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;HDACs deacetylate histones;HATs acetylate histones;HATs acetylate histones;RMTs methylate histone arginines;SIRT1 negatively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;NoRC negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;B-WICH complex positively regulates rRNA expression;DNA methylation;Transcriptional regulation by small RNAs;Activation of anterior HOX genes in hindbrain development during early embryogenesis;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;UCH proteinases;Ub-specific processing proteases;Metalloprotease DUBs;Deposition of new CENPA-containing nucleosomes at the centromere;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Estrogen-dependent gene expression;Meiotic recombination;Amyloid fiber formation |
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1686 8339 HIST1H2BG False True Meiotic synapsis;Packaging Of Telomere Ends;Pre-NOTCH Transcription and Translation;Formation of the beta-catenin:TCF transactivating complex;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;HDACs deacetylate histones;HATs acetylate histones;HATs acetylate histones;SIRT1 negatively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;NoRC negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;B-WICH complex positively regulates rRNA expression;DNA methylation;Transcriptional regulation by small RNAs;Activation of anterior HOX genes in hindbrain development during early embryogenesis;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Ub-specific processing proteases;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Processing of DNA double-strand break ends;Deposition of new CENPA-containing nucleosomes at the centromere;G2/M DNA damage checkpoint;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;E3 ubiquitin ligases ubiquitinate target proteins;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Estrogen-dependent gene expression;Meiotic recombination;Amyloid fiber formation |
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1687 8350 HIST1H3A False True Interleukin-7 signaling;Interleukin-7 signaling;Pre-NOTCH Transcription and Translation;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);HDACs deacetylate histones;PKMTs methylate histone lysines;HDMs demethylate histones;HATs acetylate histones;HATs acetylate histones;RMTs methylate histone arginines;Chromatin modifying enzymes;SIRT1 negatively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;NoRC negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;B-WICH complex positively regulates rRNA expression;DNA methylation;Transcriptional regulation by small RNAs;Activation of anterior HOX genes in hindbrain development during early embryogenesis;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Estrogen-dependent gene expression;Meiotic recombination;Amyloid fiber formation;Factors involved in megakaryocyte development and platelet production |
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1688 8359 HIST1H4A False True Meiotic synapsis;Packaging Of Telomere Ends;Pre-NOTCH Transcription and Translation;Formation of the beta-catenin:TCF transactivating complex;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;HDACs deacetylate histones;PKMTs methylate histone lysines;HDMs demethylate histones;HATs acetylate histones;HATs acetylate histones;RMTs methylate histone arginines;SIRT1 negatively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;NoRC negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;SUMOylation of chromatin organization proteins;B-WICH complex positively regulates rRNA expression;DNA methylation;Transcriptional regulation by small RNAs;Activation of anterior HOX genes in hindbrain development during early embryogenesis;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Processing of DNA double-strand break ends;Deposition of new CENPA-containing nucleosomes at the centromere;G2/M DNA damage checkpoint;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Estrogen-dependent gene expression;Meiotic recombination;Amyloid fiber formation |
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1689 8365 NA False True Meiotic synapsis;Packaging Of Telomere Ends;Pre-NOTCH Transcription and Translation;Formation of the beta-catenin:TCF transactivating complex;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;HDACs deacetylate histones;PKMTs methylate histone lysines;HDMs demethylate histones;HATs acetylate histones;HATs acetylate histones;RMTs methylate histone arginines;SIRT1 negatively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;NoRC negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;SUMOylation of chromatin organization proteins;B-WICH complex positively regulates rRNA expression;DNA methylation;Transcriptional regulation by small RNAs;Activation of anterior HOX genes in hindbrain development during early embryogenesis;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Processing of DNA double-strand break ends;Deposition of new CENPA-containing nucleosomes at the centromere;G2/M DNA damage checkpoint;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Estrogen-dependent gene expression;Meiotic recombination;Amyloid fiber formation |
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1690 8369 HIST1H4G False True NA |
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1691 8379 MAD1L1 False True Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase |
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1692 8394 PIP5K1A False True Synthesis of PIPs at the plasma membrane;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
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1693 8407 TAGLN2 False True Platelet degranulation |
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1694 8417 STX7 False True NA |
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1695 8428 STK24 False True Apoptotic cleavage of cellular proteins;Apoptotic execution phase |
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1696 8443 GNPAT False True Synthesis of PA;Plasmalogen biosynthesis;Peroxisomal protein import;Peroxisomal protein import |
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1697 8445 DYRK2 False True Regulation of TP53 Activity through Phosphorylation |
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1698 8450 CUL4B False True Recognition of DNA damage by PCNA-containing replication complex;DNA Damage Recognition in GG-NER;Formation of Incision Complex in GG-NER;Dual Incision in GG-NER;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Neddylation |
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1699 8451 CUL4A False True Recognition of DNA damage by PCNA-containing replication complex;DNA Damage Recognition in GG-NER;Formation of Incision Complex in GG-NER;Dual Incision in GG-NER;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Neddylation |
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1700 8452 CUL3 False True Degradation of DVL;Hedgehog 'on' state;Regulation of RAS by GAPs;Neddylation;Antigen processing: Ubiquitination & Proteasome degradation |
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1701 8453 CUL2 False True Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Neddylation;Regulation of expression of SLITs and ROBOs;Antigen processing: Ubiquitination & Proteasome degradation |
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1702 8454 CUL1 False True Activation of NF-kappaB in B cells;Prolactin receptor signaling;SCF-beta-TrCP mediated degradation of Emi1;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;NOTCH1 Intracellular Domain Regulates Transcription;Regulation of PLK1 Activity at G2/M Transition;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling;FCERI mediated NF-kB activation;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Circadian Clock;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;NIK-->noncanonical NF-kB signaling;MAP3K8 (TPL2)-dependent MAPK1/3 activation;Orc1 removal from chromatin;Cyclin D associated events in G1;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Neddylation;Interleukin-1 signaling;Iron uptake and transport;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation |
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1703 8463 TEAD2 False True YAP1- and WWTR1 (TAZ)-stimulated gene expression;RUNX3 regulates YAP1-mediated transcription |
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1704 8467 SMARCA5 False True NoRC negatively regulates rRNA expression;B-WICH complex positively regulates rRNA expression;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Deposition of new CENPA-containing nucleosomes at the centromere |
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1705 8470 SORBS2 False True NA |
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1706 8471 IRS4 False True IRS-related events triggered by IGF1R |
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1707 8473 OGT False True HATs acetylate histones;UCH proteinases |
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1708 8480 RAE1 False True ISG15 antiviral mechanism;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Rev-mediated nuclear export of HIV RNA;Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Viral Messenger RNA Synthesis;NEP/NS2 Interacts with the Cellular Export Machinery;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;snRNP Assembly;SUMOylation of DNA damage response and repair proteins;SUMOylation of ubiquitinylation proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;SUMOylation of SUMOylation proteins;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins;Transcriptional regulation by small RNAs;tRNA processing in the nucleus |
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1709 8495 PPFIBP2 False True Receptor-type tyrosine-protein phosphatases |
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1710 8496 PPFIBP1 False True Receptor-type tyrosine-protein phosphatases |
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1711 8498 RANBP3 False True NA |
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1712 8507 ENC1 False True NA |
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1713 8508 NIPSNAP1 False True NA |
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1714 8514 KCNAB2 False True Voltage gated Potassium channels;Neutrophil degranulation |
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1715 8517 IKBKG False True Activation of NF-kappaB in B cells;Activation of NF-kappaB in B cells;ER-Phagosome pathway;NOD1/2 Signaling Pathway;TICAM1, RIP1-mediated IKK complex recruitment ;RIP-mediated NFkB activation via ZBP1;Downstream TCR signaling;FCERI mediated NF-kB activation;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;activated TAK1 mediates p38 MAPK activation;JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1;SUMOylation of immune response proteins;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;IKBKB deficiency causes SCID;IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR);IkBA variant leads to EDA-ID;CLEC7A (Dectin-1) signaling;MAP3K8 (TPL2)-dependent MAPK1/3 activation;Ub-specific processing proteases;Ovarian tumor domain proteases;Interleukin-1 signaling;TRAF6 mediated NF-kB activation;NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10;IRAK1 recruits IKK complex;IKK complex recruitment mediated by RIP1;IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation |
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1716 8520 HAT1 False True HATs acetylate histones |
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1717 8534 CHST1 False True Keratan sulfate biosynthesis |
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1718 8536 CAMK1 False True Negative regulation of NMDA receptor-mediated neuronal transmission;Activation of RAC1 downstream of NMDARs;Activation of RAC1 downstream of NMDARs |
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1719 8539 API5 False True NA |
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1720 8543 LMO4 False True NA |
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1721 8544 PIR False True Digestion |
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1722 8546 AP3B1 False True Golgi Associated Vesicle Biogenesis;Signaling by BRAF and RAF fusions |
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1723 8550 MAPKAPK5 False True Oxidative Stress Induced Senescence;MAPK6/MAPK4 signaling;Regulation of TP53 Activity through Phosphorylation |
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1724 8559 PRPF18 False True NA |
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1725 8563 THOC5 False True Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA 3'-end processing |
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1726 8565 YARS False True Cytosolic tRNA aminoacylation |
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1727 8566 PDXK False True Neutrophil degranulation;Vitamins B6 activation to pyridoxal phosphate |
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1728 8567 MADD False True Regulation of TNFR1 signaling;RAB GEFs exchange GTP for GDP on RABs |
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1729 8569 MKNK1 False True Spry regulation of FGF signaling |
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1730 8570 KHSRP False True ATF4 activates genes;KSRP (KHSRP) binds and destabilizes mRNA;KSRP (KHSRP) binds and destabilizes mRNA |
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1731 8574 AKR7A2 False True Aflatoxin activation and detoxification |
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1732 8607 RUVBL1 False True Telomere Extension By Telomerase;Formation of the beta-catenin:TCF transactivating complex;Formation of the beta-catenin:TCF transactivating complex;HATs acetylate histones;UCH proteinases;Ub-specific processing proteases;DNA Damage Recognition in GG-NER;Deposition of new CENPA-containing nucleosomes at the centromere |
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1733 8624 PSMG1 False True NA |
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1734 8626 TP63 False True Activation of PUMA and translocation to mitochondria;TP53 Regulates Metabolic Genes;TP53 Regulates Transcription of Genes Involved in Cytochrome C Release;TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain;TP53 Regulates Transcription of Caspase Activators and Caspases;TP53 Regulates Transcription of Death Receptors and Ligands;Regulation of TP53 Activity through Association with Co-factors |
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1735 8639 AOC3 False True Phase I - Functionalization of compounds |
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1736 8658 TNKS False True TCF dependent signaling in response to WNT;Degradation of AXIN;XAV939 inhibits tankyrase, stabilizing AXIN;Ub-specific processing proteases;Regulation of PTEN stability and activity |
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1737 8659 ALDH4A1 False True Glyoxylate metabolism and glycine degradation;Proline catabolism |
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1738 8660 IRS2 False True PI3K Cascade;IRS-mediated signalling;SOS-mediated signalling;SOS-mediated signalling;PIP3 activates AKT signaling;Interleukin-7 signaling;PI3K/AKT activation;PI3K/AKT activation;Constitutive Signaling by Aberrant PI3K in Cancer;IRS-related events triggered by IGF1R;Signaling by Leptin;RAF/MAP kinase cascade;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;IRS activation;Signal attenuation;RET signaling;Signaling by Erythropoietin;Erythropoietin activates Phosphoinositide-3-kinase (PI3K);Erythropoietin activates Phosphoinositide-3-kinase (PI3K);Erythropoietin activates Phospholipase C gamma (PLCG);Erythropoietin activates STAT5;Erythropoietin activates RAS;Erythropoietin activates RAS;Growth hormone receptor signaling |
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1739 8661 EIF3A False True L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit |
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1740 8662 EIF3B False True L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit |
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1741 8663 EIF3C False True L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit |
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1742 8664 EIF3D False True L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit |
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1743 8666 EIF3G False True L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit |
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1744 8667 EIF3H False True L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit |
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1745 8668 EIF3I False True L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit |
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1746 8672 EIF4G3 False True ISG15 antiviral mechanism |
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1747 8673 VAMP8 False True ER-Phagosome pathway;Clathrin derived vesicle budding;Lysosome Vesicle Biogenesis;Golgi Associated Vesicle Biogenesis;Neutrophil degranulation;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis |
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1748 8674 VAMP4 False True Retrograde transport at the Trans-Golgi-Network;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis |
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1749 8678 BECN1 False True Macroautophagy;Ub-specific processing proteases |
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1750 8683 SRSF9 False True Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing |
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1751 8687 KRT38 False True Keratinization;Formation of the cornified envelope |
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1752 8710 NA True False NA |
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1753 8711 TNK1 False True NA |
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1754 8724 SNX3 False True WNT ligand biogenesis and trafficking;Ub-specific processing proteases |
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1755 8725 URI1 False True NA |
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1756 8729 GBF1 False True Clathrin derived vesicle budding;VxPx cargo-targeting to cilium;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic |
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1757 8733 GPAA1 False True Attachment of GPI anchor to uPAR |
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1758 8737 RIPK1 False True Caspase activation via Death Receptors in the presence of ligand;TICAM1, RIP1-mediated IKK complex recruitment ;RIP-mediated NFkB activation via ZBP1;TRIF-mediated programmed cell death;TRP channels;Regulation by c-FLIP;RIPK1-mediated regulated necrosis;CASP8 activity is inhibited;TNFR1-induced proapoptotic signaling;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;Regulation of necroptotic cell death;Ub-specific processing proteases;Ovarian tumor domain proteases;Dimerization of procaspase-8;TNF signaling;TLR3-mediated TICAM1-dependent programmed cell death;NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10;IKK complex recruitment mediated by RIP1 |
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1759 8742 TNFSF12 False True TNFR2 non-canonical NF-kB pathway;TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway |
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1760 8760 CDS2 False True Synthesis of PG |
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1761 8761 PABPC4 False True NA |
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1762 8766 RAB11A False True Translocation of SLC2A4 (GLUT4) to the plasma membrane;Vasopressin regulates renal water homeostasis via Aquaporins;Anchoring of the basal body to the plasma membrane;VxPx cargo-targeting to cilium;TBC/RABGAPs;RAB geranylgeranylation |
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1763 8775 NAPA False True COPII-mediated vesicle transport;Golgi Associated Vesicle Biogenesis;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;Intra-Golgi traffic;Retrograde transport at the Trans-Golgi-Network |
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1764 8777 MPDZ False True NA |
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1765 8786 RGS11 False True G alpha (i) signalling events;G alpha (i) signalling events;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding |
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1766 8794 TNFRSF10C False True TP53 Regulates Transcription of Death Receptors and Ligands |
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1767 8798 DYRK4 False True NA |
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1768 8799 PEX11B False True NA |
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1769 8804 CREG1 False True Neutrophil degranulation |
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1770 8805 TRIM24 False True Signaling by cytosolic FGFR1 fusion mutants;Signaling by FGFR1 in disease;Signaling by BRAF and RAF fusions |
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1771 8815 BANF1 False True Integration of provirus;2-LTR circle formation;Integration of viral DNA into host genomic DNA;Autointegration results in viral DNA circles;APOBEC3G mediated resistance to HIV-1 infection;Vpr-mediated nuclear import of PICs;Clearance of Nuclear Envelope Membranes from Chromatin;Initiation of Nuclear Envelope Reformation |
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1772 8826 IQGAP1 False True Nephrin family interactions;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;RHO GTPases activate IQGAPs;MAP2K and MAPK activation;Neutrophil degranulation;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF |
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1773 8833 GMPS False True Purine ribonucleoside monophosphate biosynthesis |
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1774 8834 TMEM11 False True Cristae formation |
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1775 8836 GGH True True Neutrophil degranulation |
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1776 8837 CFLAR False True Regulation by c-FLIP;RIPK1-mediated regulated necrosis;CASP8 activity is inhibited;Dimerization of procaspase-8;TRAIL signaling |
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1777 8844 KSR1 False True RAF activation;MAP2K and MAPK activation;Negative regulation of MAPK pathway;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF |
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1778 8848 TSC22D1 False True NA |
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1779 8856 NR1I2 False True Nuclear Receptor transcription pathway;SUMOylation of intracellular receptors |
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1780 8857 NA True False NA |
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1781 8862 APLN False True Peptide ligand-binding receptors;G alpha (i) signalling events |
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1782 8871 SYNJ2 False True Synthesis of PIPs at the plasma membrane;Clathrin-mediated endocytosis |
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1783 8872 CDC123 False True NA |
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1784 8874 ARHGEF7 False True EGFR downregulation;NRAGE signals death through JNK;Rho GTPase cycle;Ephrin signaling;G alpha (12/13) signalling events;Activation of RAC1 downstream of NMDARs |
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1785 8878 SQSTM1 False True NRIF signals cell death from the nucleus;p75NTR recruits signalling complexes;NF-kB is activated and signals survival;Pink/Parkin Mediated Mitophagy;Interleukin-1 signaling |
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1786 8880 FUBP1 False True NA |
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1787 8882 ZPR1 False True NA |
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1788 8886 DDX18 False True NA |
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1789 8888 MCM3AP False True NA |
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1790 8894 EIF2S2 False True L13a-mediated translational silencing of Ceruloplasmin expression;ABC-family proteins mediated transport;Translation initiation complex formation;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Recycling of eIF2:GDP |
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1791 8899 PRPF4B False True NA |
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1792 8907 AP1M1 False True Nef mediated downregulation of MHC class I complex cell surface expression;MHC class II antigen presentation;Lysosome Vesicle Biogenesis;Golgi Associated Vesicle Biogenesis;Neutrophil degranulation |
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1793 8911 NA False True NCAM1 interactions |
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1794 8914 TIMELESS False True Processing of DNA double-strand break ends |
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1795 8925 HERC1 False True Antigen processing: Ubiquitination & Proteasome degradation |
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1796 8943 AP3D1 False True NA |
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1797 8945 BTRC False True Activation of NF-kappaB in B cells;Prolactin receptor signaling;SCF-beta-TrCP mediated degradation of Emi1;Vpu mediated degradation of CD4;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of PLK1 Activity at G2/M Transition;FCERI mediated NF-kB activation;Deactivation of the beta-catenin transactivating complex;Circadian Clock;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;NIK-->noncanonical NF-kB signaling;MAP3K8 (TPL2)-dependent MAPK1/3 activation;Neddylation;Interleukin-1 signaling;Antigen processing: Ubiquitination & Proteasome degradation |
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1798 8971 H1FX False True NA |
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1799 8976 WASL False True Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;NOSTRIN mediated eNOS trafficking;Nephrin family interactions;EPHB-mediated forward signaling;EPHB-mediated forward signaling;DCC mediated attractive signaling;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs;Clathrin-mediated endocytosis |
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1800 8985 PLOD3 False True Collagen biosynthesis and modifying enzymes |
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1801 9020 MAP3K14 False True CD28 dependent PI3K/Akt signaling;Dectin-1 mediated noncanonical NF-kB signaling;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway |
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1802 9022 CLIC3 False True NA |
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1803 9025 RNF8 False True Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Processing of DNA double-strand break ends;G2/M DNA damage checkpoint |
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1804 9026 HIP1R False True Golgi Associated Vesicle Biogenesis;Clathrin-mediated endocytosis |
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1805 9027 NA False True Amyloid fiber formation |
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1806 9031 BAZ1B False True B-WICH complex positively regulates rRNA expression;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks |
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1807 9039 UBA3 False True Dectin-1 mediated noncanonical NF-kB signaling;NIK-->noncanonical NF-kB signaling;Neddylation;Antigen processing: Ubiquitination & Proteasome degradation |
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1808 9040 UBE2M False True TGF-beta receptor signaling activates SMADs;Dectin-1 mediated noncanonical NF-kB signaling;NIK-->noncanonical NF-kB signaling;Neddylation;Antigen processing: Ubiquitination & Proteasome degradation |
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1809 9044 BTAF1 False True NA |
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1810 9045 RPL14 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1811 9049 AIP False True Aryl hydrocarbon receptor signalling;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation |
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1812 9052 GPRC5A False True NA |
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1813 9054 NFS1 False True Mitochondrial iron-sulfur cluster biogenesis;Molybdenum cofactor biosynthesis |
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1814 9061 PAPSS1 False True Transport and synthesis of PAPS;Metabolism of ingested H2SeO4 and H2SeO3 into H2Se;Signaling by BRAF and RAF fusions |
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1815 9063 PIAS2 False True SUMOylation of DNA damage response and repair proteins;SUMOylation of transcription factors;SUMOylation of ubiquitinylation proteins;SUMOylation of transcription cofactors;SUMOylation of intracellular receptors;SUMOylation of intracellular receptors;SUMOylation of chromatin organization proteins;Activation of anterior HOX genes in hindbrain development during early embryogenesis |
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1816 9064 MAP3K6 False True NA |
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1817 9071 CLDN10 False True Tight junction interactions |
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1818 9092 SART1 False True mRNA Splicing - Major Pathway |
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1819 9093 DNAJA3 False True NA |
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1820 9094 UNC119 False True NA |
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1821 9097 USP14 False True Ub-specific processing proteases |
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1822 9099 USP2 False True TNFR1-induced proapoptotic signaling;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;Ub-specific processing proteases;Regulation of TP53 Degradation |
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1823 9101 USP8 False True Downregulation of ERBB2:ERBB3 signaling;Regulation of FZD by ubiquitination;Ub-specific processing proteases;Negative regulation of MET activity |
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1824 9104 RGN False True NA |
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1825 9111 NMI False True NA |
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1826 9118 NA False True NA |
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1827 9124 PDLIM1 False True NA |
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1828 9131 AIFM1 False True NA |
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1829 9132 KCNQ4 False True Voltage gated Potassium channels |
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1830 9135 RABEP1 False True TBC/RABGAPs |
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1831 9141 PDCD5 False True NA |
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1832 9145 SYNGR1 False True Neutrophil degranulation |
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1833 9146 HGS False True EGFR downregulation;Lysosome Vesicle Biogenesis;Ub-specific processing proteases;Negative regulation of MET activity;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;InlB-mediated entry of Listeria monocytogenes into host cell;Endosomal Sorting Complex Required For Transport (ESCRT) |
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1834 9149 DYRK1B False True NA |
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1835 9156 EXO1 False True Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha);Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta);HDR through Single Strand Annealing (SSA);HDR through Homologous Recombination (HRR);Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA);Resolution of D-loop Structures through Holliday Junction Intermediates;Homologous DNA Pairing and Strand Exchange;Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;Regulation of TP53 Activity through Phosphorylation;G2/M DNA damage checkpoint |
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1836 9180 OSMR False True IL-6-type cytokine receptor ligand interactions |
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1837 9181 ARHGEF2 False True NRAGE signals death through JNK;Rho GTPase cycle;G alpha (12/13) signalling events |
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1838 9182 RASSF9 False True NA |
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1839 9188 DDX21 False True B-WICH complex positively regulates rRNA expression;Major pathway of rRNA processing in the nucleolus and cytosol |
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1840 9191 DEDD False True NA |
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1841 9200 PTPLA False True Synthesis of very long-chain fatty acyl-CoAs |
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1842 9203 ZMYM3 False True NA |
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1843 9204 NA False True NA |
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1844 9208 LRRFIP1 False True Signaling by cytosolic FGFR1 fusion mutants;LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production;Signaling by FGFR1 in disease |
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1845 9209 LRRFIP2 False True NA |
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1846 9212 AURKB False True Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;SUMOylation of DNA replication proteins;RHO GTPases Activate Formins;Regulation of TP53 Activity through Phosphorylation;Mitotic Prometaphase;Regulation of MECP2 expression and activity |
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1847 9218 VAPA False True Sphingolipid de novo biosynthesis;Neutrophil degranulation |
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1848 9221 NOLC1 False True NA |
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1849 9223 MAGI1 False True NA |
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1850 9230 RAB11B False True TBC/RABGAPs;RAB geranylgeranylation |
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1851 9238 TBRG4 False True NA |
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1852 9240 PNMA1 False True NA |
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1853 9244 CRLF1 False True IL-6-type cytokine receptor ligand interactions;Interleukin-27 signaling |
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1854 9252 RPS6KA5 False True ERK/MAPK targets;CREB phosphorylation;NCAM signaling for neurite out-growth;Recycling pathway of L1;CD209 (DC-SIGN) signaling |
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1855 9261 MAPKAPK2 False True p38MAPK events;CREB phosphorylation;Synthesis of Leukotrienes (LT) and Eoxins (EX);Oxidative Stress Induced Senescence;Regulation of HSF1-mediated heat shock response;VEGFA-VEGFR2 Pathway;activated TAK1 mediates p38 MAPK activation;Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA;Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA |
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1856 9262 STK17B False True NA |
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1857 9266 CYTH2 False True Intra-Golgi traffic |
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1858 9271 PIWIL1 False True PIWI-interacting RNA (piRNA) biogenesis |
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1859 9275 BCL7B False True NA |
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1860 9296 ATP6V1F False True ROS, RNS production in phagocytes;Insulin receptor recycling;Transferrin endocytosis and recycling;Ion channel transport |
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1861 9306 SOCS6 False True Regulation of KIT signaling;Neddylation |
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1862 9320 TRIP12 False True Antigen processing: Ubiquitination & Proteasome degradation |
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1863 9321 TRIP11 False True Intraflagellar transport;Intra-Golgi traffic |
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1864 9330 GTF3C3 False True RNA Polymerase III Abortive And Retractive Initiation;RNA Polymerase III Transcription Initiation From Type 1 Promoter;RNA Polymerase III Transcription Initiation From Type 1 Promoter;RNA Polymerase III Transcription Initiation From Type 2 Promoter;RNA Polymerase III Transcription Initiation From Type 2 Promoter |
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1865 9341 VAMP3 False True ER-Phagosome pathway;Retrograde transport at the Trans-Golgi-Network;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis |
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1866 9343 EFTUD2 False True mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway |
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1867 9349 RPL23 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1868 9352 TXNL1 False True NA |
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1869 9361 LONP1 False True NA |
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1870 9367 RAB9A False True Retrograde transport at the Trans-Golgi-Network;RAB geranylgeranylation;RAB GEFs exchange GTP for GDP on RABs |
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1871 9373 PLAA False True NA |
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1872 9380 GRHPR False True Glyoxylate metabolism and glycine degradation |
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1873 9382 COG1 False True COPI-mediated anterograde transport;Intra-Golgi traffic;Retrograde transport at the Trans-Golgi-Network |
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1874 9400 RECQL5 False True NA |
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1875 9402 GRAP2 False True Signaling by SCF-KIT;Generation of second messenger molecules;DAP12 signaling;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;FCERI mediated Ca+2 mobilization;CD28 co-stimulation |
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1876 9404 LPXN False True NA |
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1877 9406 ZRANB2 False True NA |
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1878 9410 SNRNP40 False True mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway |
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1879 9413 FAM189A2 False True NA |
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1880 9414 TJP2 False True Signaling by Hippo;Apoptotic cleavage of cell adhesion proteins |
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1881 9416 DDX23 False True mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway |
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1882 9445 ITM2B False True Amyloid fiber formation |
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1883 9446 GSTO1 False True Methylation;Glutathione conjugation;Vitamin C (ascorbate) metabolism;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation |
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1884 9448 MAP4K4 False True Oxidative Stress Induced Senescence |
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1885 9451 EIF2AK3 False True PERK regulates gene expression |
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1886 9467 SH3BP5 False True NA |
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1887 9470 EIF4E2 False True ISG15 antiviral mechanism |
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1888 9474 ATG5 False True Macroautophagy;Macroautophagy;Pink/Parkin Mediated Mitophagy;Receptor Mediated Mitophagy;Negative regulators of DDX58/IFIH1 signaling |
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1889 9475 ROCK2 False True EPHB-mediated forward signaling;EPHB-mediated forward signaling;EPHA-mediated growth cone collapse;G alpha (12/13) signalling events;Sema4D induced cell migration and growth-cone collapse;Sema4D induced cell migration and growth-cone collapse;VEGFA-VEGFR2 Pathway;RHO GTPases Activate ROCKs;RHO GTPases Activate ROCKs |
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1890 9482 STX8 False True NA |
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1891 9491 PSMF1 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation |
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1892 9493 KIF23 False True MHC class II antigen presentation;COPI-dependent Golgi-to-ER retrograde traffic;Mitotic Telophase/Cytokinesis;Kinesins |
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1893 9512 PMPCB False True Mitochondrial protein import;Processing of SMDT1 |
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1894 9520 NPEPPS False True Antigen processing: Ubiquitination & Proteasome degradation |
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1895 9522 SCAMP1 False True Neutrophil degranulation |
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1896 9524 TECR False True Synthesis of very long-chain fatty acyl-CoAs |
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1897 9529 BAG5 False True Regulation of HSF1-mediated heat shock response |
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1898 9530 BAG4 False True Regulation of HSF1-mediated heat shock response;Signaling by FGFR1 in disease;TNF signaling;Signaling by plasma membrane FGFR1 fusions |
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1899 9531 BAG3 False True Regulation of HSF1-mediated heat shock response |
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1900 9532 BAG2 False True Regulation of HSF1-mediated heat shock response |
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1901 9547 CXCL14 False True NA |
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1902 9551 ATP5J2 False True Formation of ATP by chemiosmotic coupling;Cristae formation |
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1903 9554 SEC22B False True ER-Phagosome pathway;COPII-mediated vesicle transport;Cargo concentration in the ER;COPI-dependent Golgi-to-ER retrograde traffic |
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1904 9555 H2AFY False True NA |
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1905 9557 CHD1L False True Formation of Incision Complex in GG-NER;Dual Incision in GG-NER |
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1906 9564 BCAR1 False True Downstream signal transduction;p130Cas linkage to MAPK signaling for integrins;VEGFA-VEGFR2 Pathway;VEGFA-VEGFR2 Pathway;PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases |
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1907 9570 GOSR2 False True COPII-mediated vesicle transport;XBP1(S) activates chaperone genes;Cargo concentration in the ER;COPI-mediated anterograde transport;Intra-Golgi traffic |
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1908 9584 RBM39 False True NA |
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1909 9586 CREB5 False True NA |
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1910 9587 MAD2L1BP False True NA |
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1911 9588 PRDX6 False True Detoxification of Reactive Oxygen Species;Neutrophil degranulation |
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1912 9601 PDIA4 False True NA |
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1913 9612 NCOR2 False True PPARA activates gene expression;NOTCH1 Intracellular Domain Regulates Transcription;Downregulation of SMAD2/3:SMAD4 transcriptional activity;Downregulation of SMAD2/3:SMAD4 transcriptional activity;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;HDACs deacetylate histones;Transcriptional regulation of white adipocyte differentiation;Transcriptional regulation of white adipocyte differentiation;SUMOylation of transcription cofactors;Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha);Loss of MECP2 binding ability to the NCoR/SMRT complex;Regulation of MECP2 expression and activity |
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1914 9628 RGS6 False True G alpha (i) signalling events;G alpha (i) signalling events;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding |
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1915 9631 NUP155 False True ISG15 antiviral mechanism;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Rev-mediated nuclear export of HIV RNA;Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Viral Messenger RNA Synthesis;NEP/NS2 Interacts with the Cellular Export Machinery;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;snRNP Assembly;SUMOylation of DNA damage response and repair proteins;SUMOylation of ubiquitinylation proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;SUMOylation of SUMOylation proteins;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins;Transcriptional regulation by small RNAs;tRNA processing in the nucleus |
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1916 9632 SEC24C False True Regulation of cholesterol biosynthesis by SREBP (SREBF);COPII-mediated vesicle transport;MHC class II antigen presentation;Cargo concentration in the ER;Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
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1917 9635 CLCA2 False True Stimuli-sensing channels |
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1918 9636 ISG15 False True ISG15 antiviral mechanism;NS1 Mediated Effects on Host Pathways;DDX58/IFIH1-mediated induction of interferon-alpha/beta;Termination of translesion DNA synthesis;Interferon alpha/beta signaling;Negative regulators of DDX58/IFIH1 signaling |
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1919 9641 IKBKE False True SUMOylation of immune response proteins;TICAM1-dependent activation of IRF3/IRF7;TRAF3-dependent IRF activation pathway;TRAF6 mediated IRF7 activation;Negative regulators of DDX58/IFIH1 signaling;Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon |
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1920 9647 PPM1F False True Negative regulation of NMDA receptor-mediated neuronal transmission |
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1921 9650 NA False True NA |
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1922 9656 MDC1 False True SUMOylation of DNA damage response and repair proteins;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Processing of DNA double-strand break ends;TP53 Regulates Transcription of DNA Repair Genes;G2/M DNA damage checkpoint |
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1923 9669 EIF5B False True GTP hydrolysis and joining of the 60S ribosomal subunit |
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1924 9673 SLC25A44 False True NA |
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1925 9681 DEPDC5 False True NA |
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1926 9685 CLINT1 False True Golgi Associated Vesicle Biogenesis |
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1927 9688 NUP93 False True ISG15 antiviral mechanism;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Rev-mediated nuclear export of HIV RNA;Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Viral Messenger RNA Synthesis;NEP/NS2 Interacts with the Cellular Export Machinery;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;snRNP Assembly;SUMOylation of DNA damage response and repair proteins;SUMOylation of ubiquitinylation proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;SUMOylation of SUMOylation proteins;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins;Transcriptional regulation by small RNAs;tRNA processing in the nucleus |
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1928 9689 BZW1 False True NA |
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1929 9698 PUM1 False True Golgi Associated Vesicle Biogenesis |
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1930 9702 CEP57 False True Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;AURKA Activation by TPX2 |
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1931 9711 KIAA0226 False True NA |
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1932 9721 GPRIN2 False True NA |
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1933 9729 KIAA0408 False True NA |
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1934 9734 HDAC9 False True NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants |
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1935 9743 ARHGAP32 False True Rho GTPase cycle |
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1936 9750 FAM65B False True NA |
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1937 9753 ZSCAN12 False True NA |
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1938 9757 KMT2B False True PKMTs methylate histone lysines;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function |
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1939 9759 HDAC4 False True NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;SUMOylation of intracellular receptors;SUMOylation of chromatin organization proteins;RUNX2 regulates chondrocyte maturation;RUNX3 regulates p14-ARF |
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1940 9772 NA False True NA |
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1941 9775 EIF4A3 False True Cleavage of Growing Transcript in the Termination Region ;ISG15 antiviral mechanism;Transport of Mature mRNA derived from an Intron-Containing Transcript;Deadenylation of mRNA;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1942 9777 TM9SF4 False True NA |
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1943 9778 KIAA0232 False True NA |
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1944 9782 MATR3 False True NA |
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1945 9787 DLGAP5 False True NOTCH3 Intracellular Domain Regulates Transcription |
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1946 9790 BMS1 False True rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol |
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1947 9793 CKAP5 False True Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;RHO GTPases Activate Formins;Mitotic Prometaphase;AURKA Activation by TPX2 |
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1948 9798 IST1 False True Neutrophil degranulation |
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1949 9810 RNF40 False True E3 ubiquitin ligases ubiquitinate target proteins |
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1950 9815 GIT2 False True NA |
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1951 9816 NA False True NA |
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1952 9817 KEAP1 False True Ub-specific processing proteases;Neddylation;Antigen processing: Ubiquitination & Proteasome degradation |
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1953 9824 NA False True Rho GTPase cycle |
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1954 9828 NA False True NRAGE signals death through JNK;Rho GTPase cycle;G alpha (12/13) signalling events |
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1955 9836 LCMT2 False True Synthesis of wybutosine at G37 of tRNA(Phe);Synthesis of wybutosine at G37 of tRNA(Phe) |
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1956 9846 GAB2 False True PI3K Cascade;Signaling by SCF-KIT;Signaling by cytosolic FGFR1 fusion mutants;Role of LAT2/NTAL/LAB on calcium mobilization;Role of LAT2/NTAL/LAB on calcium mobilization;RET signaling;Interleukin-15 signaling;Interleukin receptor SHC signaling |
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1957 9847 NA False True Translocation of SLC2A4 (GLUT4) to the plasma membrane |
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1958 9849 ZNF518A False True NA |
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1959 9859 CEP170 False True NA |
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1960 9861 PSMD6 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation |
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1961 9868 TOMM70A False True Mitochondrial protein import;Pink/Parkin Mediated Mitophagy;Ub-specific processing proteases |
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1962 9869 SETDB1 False True PKMTs methylate histone lysines |
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1963 9870 AREL1 False True Antigen processing: Ubiquitination & Proteasome degradation |
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1964 9874 TLK1 False True NA |
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1965 9877 NA False True Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA 3'-end processing |
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1966 9878 TOX4 False True NA |
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1967 9879 DDX46 False True mRNA Splicing - Major Pathway |
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1968 9882 TBC1D4 False True Translocation of SLC2A4 (GLUT4) to the plasma membrane |
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1969 9883 POM121 False True ISG15 antiviral mechanism;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Rev-mediated nuclear export of HIV RNA;Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Viral Messenger RNA Synthesis;NEP/NS2 Interacts with the Cellular Export Machinery;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;snRNP Assembly;SUMOylation of DNA damage response and repair proteins;SUMOylation of ubiquitinylation proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;SUMOylation of SUMOylation proteins;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins;Transcriptional regulation by small RNAs;tRNA processing in the nucleus |
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1970 9886 RHOBTB1 False True Rho GTPase cycle |
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1971 9889 ZBED4 False True NA |
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1972 9894 TELO2 False True NA |
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1973 9897 KIAA0196 False True NA |
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1974 9908 G3BP2 False True NA |
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1975 9918 NCAPD2 False True Condensation of Prometaphase Chromosomes;Condensation of Prometaphase Chromosomes |
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1976 9919 SEC16A False True COPII-mediated vesicle transport |
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1977 9921 RNF10 False True NA |
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1978 9939 RBM8A False True Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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1979 9948 WDR1 False True Platelet degranulation |
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1980 9958 USP15 False True Downregulation of TGF-beta receptor signaling;UCH proteinases;Ub-specific processing proteases |
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1981 9961 MVP False True Neutrophil degranulation |
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1982 9967 THRAP3 False True PPARA activates gene expression;Transcriptional regulation of white adipocyte differentiation;Transcriptional regulation of white adipocyte differentiation |
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1983 9970 NR1I3 False True Nuclear Receptor transcription pathway |
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1984 9972 NUP153 False True ISG15 antiviral mechanism;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Rev-mediated nuclear export of HIV RNA;Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Viral Messenger RNA Synthesis;NEP/NS2 Interacts with the Cellular Export Machinery;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;snRNP Assembly;SUMOylation of DNA damage response and repair proteins;SUMOylation of ubiquitinylation proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;SUMOylation of SUMOylation proteins;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins;Transcriptional regulation by small RNAs;tRNA processing in the nucleus |
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1985 9973 CCS False True Detoxification of Reactive Oxygen Species;Detoxification of Reactive Oxygen Species |
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1986 9978 RBX1 False True Recognition of DNA damage by PCNA-containing replication complex;Prolactin receptor signaling;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Vif-mediated degradation of APOBEC3G;Degradation of beta-catenin by the destruction complex;NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Degradation of DVL;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;DNA Damage Recognition in GG-NER;Formation of Incision Complex in GG-NER;Dual Incision in GG-NER;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Orc1 removal from chromatin;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation |
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1987 9987 HNRNPDL False True Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation |
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1988 9997 SCO2 False True TP53 Regulates Metabolic Genes;Respiratory electron transport |
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1989 10009 ZBTB33 False True NA |
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1990 10013 HDAC6 False True NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;HSF1 activation;Cilium Assembly;Transcriptional regulation by RUNX2;RUNX2 regulates osteoblast differentiation |
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1991 10015 PDCD6IP False True Budding and maturation of HIV virion;Uptake and function of anthrax toxins |
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1992 10016 PDCD6 False True NA |
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1993 10026 PIGK False True Attachment of GPI anchor to uPAR |
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1994 10036 CHAF1A False True NA |
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1995 10040 TOM1L1 False True NA |
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1996 10045 SH2D3A False True NA |
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1997 10048 RANBP9 False True L1CAM interactions;RAF/MAP kinase cascade;MET activates RAS signaling |
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1998 10049 DNAJB6 False True Regulation of HSF1-mediated heat shock response |
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1999 10051 SMC4 False True Condensation of Prophase Chromosomes;Condensation of Prometaphase Chromosomes;Condensation of Prometaphase Chromosomes |
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2000 10054 UBA2 False True SUMO is conjugated to E1 (UBA2:SAE1);SUMO is conjugated to E1 (UBA2:SAE1);SUMO is transferred from E1 to E2 (UBE2I, UBC9);SUMO is transferred from E1 to E2 (UBE2I, UBC9) |
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2001 10055 SAE1 False True SUMO is conjugated to E1 (UBA2:SAE1);SUMO is conjugated to E1 (UBA2:SAE1);SUMO is transferred from E1 to E2 (UBE2I, UBC9);SUMO is transferred from E1 to E2 (UBE2I, UBC9) |
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2002 10056 FARSB False True Cytosolic tRNA aminoacylation |
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2003 10059 DNM1L False True Apoptotic execution phase |
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2004 10060 NA False True ATP sensitive Potassium channels;ABC-family proteins mediated transport;Ion homeostasis;Defective ABCC9 causes dilated cardiomyopathy 10, familial atrial fibrillation 12 and hypertrichotic osteochondrodysplasia |
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2005 10062 NR1H3 False True PPARA activates gene expression;Nuclear Receptor transcription pathway;SUMOylation of intracellular receptors;VLDLR internalisation and degradation |
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2006 10063 COX17 False True Mitochondrial protein import |
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2007 10075 HUWE1 False True Neutrophil degranulation;Antigen processing: Ubiquitination & Proteasome degradation |
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2008 10092 ARPC5 False True Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;EPHB-mediated forward signaling;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs;Neutrophil degranulation;Clathrin-mediated endocytosis |
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2009 10093 ARPC4 True True Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;EPHB-mediated forward signaling;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs;Clathrin-mediated endocytosis |
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2010 10094 ARPC3 False True Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;EPHB-mediated forward signaling;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs;Clathrin-mediated endocytosis |
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2011 10095 ARPC1B False True Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;EPHB-mediated forward signaling;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs |
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2012 10096 ACTR3 False True Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;EPHB-mediated forward signaling;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs;Clathrin-mediated endocytosis |
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2013 10097 ACTR2 True True Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;EPHB-mediated forward signaling;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs;Neutrophil degranulation;Clathrin-mediated endocytosis |
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2014 10100 TSPAN2 False True NA |
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2015 10105 PPIF False True NA |
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2016 10107 TRIM10 False True Interferon gamma signaling |
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2017 10109 ARPC2 False True Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;EPHB-mediated forward signaling;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs;Clathrin-mediated endocytosis |
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2018 10110 SGK2 False True Stimuli-sensing channels |
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2019 10113 PREB False True COPII-mediated vesicle transport;XBP1(S) activates chaperone genes;Cargo concentration in the ER |
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2020 10128 LRPPRC False True TP53 Regulates Metabolic Genes;Respiratory electron transport |
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2021 10130 PDIA6 False True XBP1(S) activates chaperone genes;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation |
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2022 10131 TRAP1 False True Respiratory electron transport |
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2023 10133 OPTN False True Regulation of PLK1 Activity at G2/M Transition;TBC/RABGAPs |
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2024 10134 BCAP31 False True Apoptotic cleavage of cellular proteins;Apoptotic execution phase;Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
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2025 10135 NAMPT False True BMAL1:CLOCK,NPAS2 activates circadian gene expression;Nicotinamide salvaging |
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2026 10141 LINC01587 False True NA |
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2027 10146 G3BP1 False True NA |
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2028 10150 MBNL2 False True NA |
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2029 10152 ABI2 False True Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;VEGFA-VEGFR2 Pathway;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs |
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2030 10155 TRIM28 False True Generic Transcription Pathway;SUMOylation of transcription cofactors |
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2031 10165 SLC25A13 False True Mitochondrial protein import;Gluconeogenesis |
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2032 10168 ZNF197 False True Generic Transcription Pathway |
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2033 10169 SERF2 False True NA |
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2034 10174 SORBS3 False True Smooth Muscle Contraction |
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2035 10180 RBM6 False True NA |
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2036 10181 RBM5 False True mRNA Splicing - Major Pathway |
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2037 10188 TNK2 False True NA |
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2038 10189 ALYREF False True Cleavage of Growing Transcript in the Termination Region ;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing |
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2039 10190 TXNDC9 False True NA |
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2040 10195 ALG3 False True Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein;Defective ALG3 causes ALG3-CDG (CDG-1d) |
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2041 10197 PSME3 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation |
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2042 10198 NA False True NA |
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2043 10200 MPHOSPH6 False True Major pathway of rRNA processing in the nucleolus and cytosol |
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2044 10204 NUTF2 False True NA |
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2045 10211 FLOT1 False True Synaptic adhesion-like molecules |
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2046 10213 PSMD14 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;Metalloprotease DUBs;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation |
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2047 10226 PLIN3 False True Triglyceride catabolism;Retrograde transport at the Trans-Golgi-Network |
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2048 10228 STX6 False True Intra-Golgi traffic;Retrograde transport at the Trans-Golgi-Network |
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2049 10236 HNRNPR False True mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA |
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2050 10238 DCAF7 False True Association of TriC/CCT with target proteins during biosynthesis;Neddylation |
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2051 10250 SRRM1 False True Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing |
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2052 10260 DENND4A False True RAB GEFs exchange GTP for GDP on RABs |
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2053 10270 AKAP8 False True NA |
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2054 10273 STUB1 False True Downregulation of TGF-beta receptor signaling;Downregulation of ERBB2 signaling;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity;Antigen processing: Ubiquitination & Proteasome degradation |
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2055 10283 CWC27 False True mRNA Splicing - Major Pathway |
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2056 10284 SAP18 False True HDACs deacetylate histones;NoRC negatively regulates rRNA expression |
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2057 10286 BCAS2 False True mRNA Splicing - Major Pathway |
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2058 10291 SF3A1 False True mRNA Splicing - Major Pathway |
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2059 10294 DNAJA2 False True HSP90 chaperone cycle for steroid hormone receptors (SHR) |
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2060 10298 PAK4 False True Activation of RAC1 |
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2061 10309 NA False True NA |
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2062 10313 RTN3 False True Synaptic adhesion-like molecules |
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2063 10319 LAMC3 False True Laminin interactions;Laminin interactions;Non-integrin membrane-ECM interactions;MET activates PTK2 signaling |
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2064 10327 AKR1A1 False True Glutathione conjugation;Formation of xylulose-5-phosphate |
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2065 10336 PCGF3 False True NA |
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2066 10342 TFG False True COPII-mediated vesicle transport |
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2067 10350 NA False True ABC transporters in lipid homeostasis |
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2068 10362 HMG20B False True HDACs deacetylate histones;Factors involved in megakaryocyte development and platelet production |
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2069 10367 MICU1 False True Mitochondrial calcium ion transport;Processing of SMDT1 |
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2070 10376 TUBA1B True True Translocation of SLC2A4 (GLUT4) to the plasma membrane;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;Gap junction assembly;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HSP90 chaperone cycle for steroid hormone receptors (SHR);Recruitment of NuMA to mitotic centrosomes;Formation of tubulin folding intermediates by CCT/TriC;Post-chaperonin tubulin folding pathway;Recycling pathway of L1;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;Carboxyterminal post-translational modifications of tubulin;Carboxyterminal post-translational modifications of tubulin;Activation of AMPK downstream of NMDARs;Kinesins |
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2071 10381 TUBB3 False True Translocation of SLC2A4 (GLUT4) to the plasma membrane;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;Gap junction assembly;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HSP90 chaperone cycle for steroid hormone receptors (SHR);Recruitment of NuMA to mitotic centrosomes;Prefoldin mediated transfer of substrate to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Post-chaperonin tubulin folding pathway;Recycling pathway of L1;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;Carboxyterminal post-translational modifications of tubulin;Carboxyterminal post-translational modifications of tubulin;Activation of AMPK downstream of NMDARs;Kinesins |
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2072 10383 TUBB4B True True Translocation of SLC2A4 (GLUT4) to the plasma membrane;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;Gap junction assembly;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;Regulation of PLK1 Activity at G2/M Transition;HSP90 chaperone cycle for steroid hormone receptors (SHR);Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Prefoldin mediated transfer of substrate to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Post-chaperonin tubulin folding pathway;Recycling pathway of L1;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Anchoring of the basal body to the plasma membrane;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;Neutrophil degranulation;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;AURKA Activation by TPX2;Carboxyterminal post-translational modifications of tubulin;Carboxyterminal post-translational modifications of tubulin;Activation of AMPK downstream of NMDARs;Kinesins |
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2073 10385 BTN2A2 False True Butyrophilin (BTN) family interactions |
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2074 10389 SCML2 False True NA |
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2075 10391 CORO2B False True NA |
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2076 10398 MYL9 False True EPHA-mediated growth cone collapse;Sema4D induced cell migration and growth-cone collapse;Smooth Muscle Contraction;RHO GTPases activate PKNs;RHO GTPases activate CIT;RHO GTPases Activate ROCKs;RHO GTPases activate PAKs;RHO GTPases activate PAKs;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function |
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2077 10399 GNB2L1 False True Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;TNFR1-mediated ceramide production |
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2078 10403 NDC80 False True Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase |
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2079 10406 WFDC2 False True NA |
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2080 10409 BASP1 False True NA |
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2081 10413 YAP1 False True Nuclear signaling by ERBB4;Signaling by Hippo;YAP1- and WWTR1 (TAZ)-stimulated gene expression;RUNX1 regulates transcription of genes involved in differentiation of HSCs;RUNX2 regulates osteoblast differentiation;RUNX3 regulates YAP1-mediated transcription |
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2082 10419 PRMT5 False True snRNP Assembly;RMTs methylate histone arginines;Regulation of TP53 Activity through Methylation |
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2083 10420 TESK2 False True NA |
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2084 10421 CD2BP2 False True mRNA Splicing - Major Pathway |
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2085 10424 NA False True NA |
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2086 10432 RBM14 False True RUNX2 regulates bone development |
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2087 10444 ZER1 False True NA |
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2088 10447 FAM3C False True Platelet degranulation |
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2089 10449 ACAA2 False True Mitochondrial Fatty Acid Beta-Oxidation |
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2090 10452 TOMM40 False True Mitochondrial protein import;Pink/Parkin Mediated Mitophagy |
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2091 10454 TAB1 False True NOD1/2 Signaling Pathway;FCERI mediated NF-kB activation;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;activated TAK1 mediates p38 MAPK activation;JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1;TNFR1-induced NFkappaB signaling pathway;CLEC7A (Dectin-1) signaling;Ub-specific processing proteases;TICAM1,TRAF6-dependent induction of TAK1 complex;Interleukin-1 signaling;IRAK2 mediated activation of TAK1 complex;TRAF6-mediated induction of TAK1 complex within TLR4 complex;IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |
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2092 10458 BAIAP2 False True Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;VEGFA-VEGFR2 Pathway;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs |
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2093 10460 TACC3 False True NOTCH3 Activation and Transmission of Signal to the Nucleus;Negative regulation of NOTCH4 signaling |
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2094 10461 MERTK False True Cell surface interactions at the vascular wall |
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2095 10468 FST False True Antagonism of Activin by Follistatin |
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2096 10469 TIMM44 False True Mitochondrial protein import |
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2097 10475 TRIM38 False True Interferon gamma signaling |
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2098 10476 ATP5H False True Formation of ATP by chemiosmotic coupling;Cristae formation |
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2099 10480 EIF3M False True L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit |
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2100 10486 CAP2 False True Role of ABL in ROBO-SLIT signaling |
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2101 10488 CREB3 False True CREB3 factors activate genes;CREB3 factors activate genes |
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2102 10490 VTI1B False True Platelet degranulation |
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2103 10491 CRTAP False True Collagen biosynthesis and modifying enzymes |
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2104 10492 SYNCRIP False True NA |
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2105 10493 VAT1 False True Neutrophil degranulation |
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2106 10498 CARM1 False True RORA activates gene expression;BMAL1:CLOCK,NPAS2 activates circadian gene expression;PPARA activates gene expression;PPARA activates gene expression;Transcriptional activation of mitochondrial biogenesis;Activation of gene expression by SREBF (SREBP);RMTs methylate histone arginines;Transcriptional regulation of white adipocyte differentiation;Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha);Circadian Clock;TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest;Estrogen-dependent gene expression |
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2107 10513 APPBP2 False True NA |
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2108 10514 MYBBP1A False True B-WICH complex positively regulates rRNA expression |
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2109 10521 DDX17 False True SUMOylation of transcription cofactors |
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2110 10523 CHERP False True mRNA Splicing - Major Pathway |
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2111 10524 KAT5 False True Formation of the beta-catenin:TCF transactivating complex;Formation of the beta-catenin:TCF transactivating complex;DNA Damage/Telomere Stress Induced Senescence;HATs acetylate histones;HDR through Single Strand Annealing (SSA);HDR through Homologous Recombination (HRR);Sensing of DNA Double Strand Breaks;Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA);Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Resolution of D-loop Structures through Holliday Junction Intermediates;Nonhomologous End-Joining (NHEJ);Homologous DNA Pairing and Strand Exchange;Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;Regulation of TP53 Activity through Phosphorylation;G2/M DNA damage checkpoint;Estrogen-dependent gene expression |
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2112 10525 HYOU1 False True Scavenging by Class F Receptors;Scavenging by Class F Receptors;XBP1(S) activates chaperone genes |
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2113 10526 IPO8 False True Transcriptional regulation by small RNAs |
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2114 10527 IPO7 False True NA |
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2115 10528 NOP56 False True Association of TriC/CCT with target proteins during biosynthesis;rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol |
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2116 10531 PITRM1 False True Mitochondrial protein import |
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2117 10540 DCTN2 False True MHC class II antigen presentation;Regulation of PLK1 Activity at G2/M Transition;HSP90 chaperone cycle for steroid hormone receptors (SHR);Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;COPI-mediated anterograde transport;COPI-independent Golgi-to-ER retrograde traffic;AURKA Activation by TPX2 |
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2118 10542 LAMTOR5 False True Macroautophagy;mTOR signalling;mTORC1-mediated signalling;Energy dependent regulation of mTOR by LKB1-AMPK;TP53 Regulates Metabolic Genes;Regulation of PTEN gene transcription |
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2119 10544 PROCR False True Common Pathway of Fibrin Clot Formation;Cell surface interactions at the vascular wall |
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2120 10549 PRDX4 False True Neutrophil degranulation |
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2121 10552 ARPC1A False True Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;EPHB-mediated forward signaling;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs;Clathrin-mediated endocytosis |
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2122 10559 SLC35A1 False True Sialic acid metabolism;Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F);Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F);Transport of nucleotide sugars |
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2123 10567 RABAC1 False True NA |
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2124 10569 SLU7 False True Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing |
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2125 10570 DPYSL4 False True CRMPs in Sema3A signaling |
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2126 10573 MRPL28 False True Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation elongation;Mitochondrial translation termination |
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2127 10574 CCT7 False True Prefoldin mediated transfer of substrate to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Folding of actin by CCT/TriC;Association of TriC/CCT with target proteins during biosynthesis;Association of TriC/CCT with target proteins during biosynthesis;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding |
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2128 10575 CCT4 False True Prefoldin mediated transfer of substrate to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Folding of actin by CCT/TriC;Association of TriC/CCT with target proteins during biosynthesis;Association of TriC/CCT with target proteins during biosynthesis;BBSome-mediated cargo-targeting to cilium;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding |
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2129 10576 CCT2 False True Prefoldin mediated transfer of substrate to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Folding of actin by CCT/TriC;Association of TriC/CCT with target proteins during biosynthesis;Association of TriC/CCT with target proteins during biosynthesis;BBSome-mediated cargo-targeting to cilium;Neutrophil degranulation;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding |
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2130 10577 NPC2 True True Neutrophil degranulation;LDL clearance |
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2131 10580 SORBS1 False True Smooth Muscle Contraction |
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2132 10584 COLEC10 False True Lectin pathway of complement activation;Initial triggering of complement |
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2133 10591 DNPH1 False True Purine catabolism |
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2134 10594 PRPF8 False True mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway |
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2135 10598 AHSA1 False True NA |
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2136 10607 TBL3 False True rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol |
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2137 10611 PDLIM5 False True Neurexins and neuroligins |
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2138 10616 RBCK1 False True Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;Antigen processing: Ubiquitination & Proteasome degradation |
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2139 10618 TGOLN2 False True Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Golgi Associated Vesicle Biogenesis;Retrograde transport at the Trans-Golgi-Network;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Post-translational protein phosphorylation |
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2140 10625 IVNS1ABP False True NA |
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2141 10627 MYL12A False True EPHA-mediated growth cone collapse;Ephrin signaling;Sema4D induced cell migration and growth-cone collapse;Smooth Muscle Contraction;RHO GTPases activate PKNs;RHO GTPases activate CIT;RHO GTPases Activate ROCKs;RHO GTPases activate PAKs;RHO GTPases activate PAKs |
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2142 10628 TXNIP False True The NLRP3 inflammasome;The NLRP3 inflammasome;Regulation of FOXO transcriptional activity by acetylation |
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2143 10641 NPRL2 False True NA |
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2144 10645 CAMKK2 False True CaMK IV-mediated phosphorylation of CREB;CaMK IV-mediated phosphorylation of CREB;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;Activation of RAC1 downstream of NMDARs;Activation of RAC1 downstream of NMDARs;Activation of AMPK downstream of NMDARs |
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2145 10650 NA False True TP53 Regulates Transcription of Genes Involved in Cytochrome C Release |
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2146 10652 YKT6 False True COPII-mediated vesicle transport;COPI-mediated anterograde transport;Intra-Golgi traffic |
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2147 10656 KHDRBS3 False True PTK6 Regulates Proteins Involved in RNA Processing |
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2148 10667 FARS2 False True Mitochondrial tRNA aminoacylation |
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2149 10671 DCTN6 False True MHC class II antigen presentation;HSP90 chaperone cycle for steroid hormone receptors (SHR);COPI-mediated anterograde transport;COPI-independent Golgi-to-ER retrograde traffic |
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2150 10682 EBP False True Cholesterol biosynthesis via desmosterol;Cholesterol biosynthesis via lathosterol |
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2151 10687 PNMA2 False True NA |
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2152 10693 CCT6B False True Prefoldin mediated transfer of substrate to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Folding of actin by CCT/TriC;Association of TriC/CCT with target proteins during biosynthesis;Association of TriC/CCT with target proteins during biosynthesis;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding |
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2153 10694 CCT8 False True Prefoldin mediated transfer of substrate to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Folding of actin by CCT/TriC;Association of TriC/CCT with target proteins during biosynthesis;Association of TriC/CCT with target proteins during biosynthesis;BBSome-mediated cargo-targeting to cilium;Neutrophil degranulation;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding |
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2154 10726 NUDC False True Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Mitotic Telophase/Cytokinesis |
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2155 10728 PTGES3 False True Synthesis of Prostaglandins (PG) and Thromboxanes (TX);HSP90 chaperone cycle for steroid hormone receptors (SHR);HSF1 activation;Attenuation phase;Aryl hydrocarbon receptor signalling;ESR-mediated signaling;Estrogen-dependent gene expression |
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2156 10733 PLK4 False True Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;AURKA Activation by TPX2 |
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2157 10745 PHTF1 False True NA |
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2158 10746 MAP3K2 False True NA |
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2159 10749 KIF1C False True COPI-dependent Golgi-to-ER retrograde traffic;Kinesins |
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2160 10762 NUP50 False True ISG15 antiviral mechanism;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Rev-mediated nuclear export of HIV RNA;Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Viral Messenger RNA Synthesis;NEP/NS2 Interacts with the Cellular Export Machinery;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;snRNP Assembly;SUMOylation of DNA damage response and repair proteins;SUMOylation of ubiquitinylation proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;SUMOylation of SUMOylation proteins;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins;Transcriptional regulation by small RNAs;tRNA processing in the nucleus |
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2161 10763 NES False True NA |
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2162 10768 AHCYL1 False True PLC beta mediated events;DAG and IP3 signaling;Role of phospholipids in phagocytosis;FCERI mediated Ca+2 mobilization;Regulation of insulin secretion;VEGFR2 mediated cell proliferation;Ion homeostasis;Ion homeostasis;CLEC7A (Dectin-1) induces NFAT activation;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
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2163 10772 SRSF10 False True mRNA Splicing - Major Pathway |
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2164 10783 NEK6 False True Activation of NIMA Kinases NEK9, NEK6, NEK7;Nuclear Pore Complex (NPC) Disassembly |
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2165 10785 WDR4 False True tRNA modification in the nucleus and cytosol |
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2166 10787 NCKAP1 False True Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;VEGFA-VEGFR2 Pathway;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs |
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2167 10791 NA False True NA |
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2168 10797 MTHFD2 False True Metabolism of folate and pterines |
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2169 10801 SEPT9 False True NA |
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2170 10802 SEC24A False True Regulation of cholesterol biosynthesis by SREBP (SREBF);COPII-mediated vesicle transport;MHC class II antigen presentation;Cargo concentration in the ER;Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
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2171 10808 HSPH1 False True Scavenging by Class F Receptors;Scavenging by Class F Receptors;Regulation of HSF1-mediated heat shock response |
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2172 10826 NA False True NA |
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2173 10845 CLPX False True NA |
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2174 10856 RUVBL2 False True Telomere Extension By Telomerase;HATs acetylate histones |
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2175 10868 USP20 False True Ub-specific processing proteases |
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2176 10869 USP19 False True Ub-specific processing proteases |
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2177 10890 RAB10 False True Translocation of SLC2A4 (GLUT4) to the plasma membrane;Neutrophil degranulation;RAB geranylgeranylation;RAB GEFs exchange GTP for GDP on RABs |
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2178 10906 TRAFD1 False True NA |
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2179 10907 TXNL4A False True mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway |
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2180 10910 SUGT1 False True The NLRP3 inflammasome |
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2181 10912 GADD45G False True NA |
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2182 10914 PAPOLA False True Cleavage of Growing Transcript in the Termination Region ;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Processing of Intronless Pre-mRNAs |
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2183 10916 MAGED2 False True Platelet degranulation |
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2184 10921 RNPS1 False True Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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2185 10922 FASTK False True NA |
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2186 10923 SUB1 False True NA |
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2187 10927 SPIN1 False True NA |
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2188 10928 RALBP1 False True Rho GTPase cycle |
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2189 10929 SRSF8 False True NA |
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2190 10933 MORF4L1 False True HATs acetylate histones |
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2191 10935 PRDX3 False True Detoxification of Reactive Oxygen Species |
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2192 10938 EHD1 False True Factors involved in megakaryocyte development and platelet production |
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2193 10946 SF3A3 False True mRNA Splicing - Major Pathway |
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2194 10948 STARD3 False True Pregnenolone biosynthesis |
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2195 10949 HNRNPA0 False True mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA |
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2196 10951 CBX1 False True NA |
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2197 10953 TOMM34 False True NA |
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2198 10956 OS9 False True ABC-family proteins mediated transport;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Defective CFTR causes cystic fibrosis;ER Quality Control Compartment (ERQC) |
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2199 10963 STIP1 False True HSP90 chaperone cycle for steroid hormone receptors (SHR) |
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2200 10970 CKAP4 False True Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Surfactant metabolism;Neutrophil degranulation;Post-translational protein phosphorylation |
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2201 10971 YWHAQ False True Activation of BAD and translocation to mitochondria ;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Translocation of SLC2A4 (GLUT4) to the plasma membrane;RHO GTPases activate PKNs;TP53 Regulates Metabolic Genes;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;Regulation of localization of FOXO transcription factors |
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2202 10973 ASCC3 False True ALKBH3 mediated reversal of alkylation damage |
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2203 10979 FERMT2 False True Cell-extracellular matrix interactions |
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2204 10980 COPS6 False True DNA Damage Recognition in GG-NER;Formation of TC-NER Pre-Incision Complex;Cargo recognition for clathrin-mediated endocytosis;Neddylation |
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2205 10982 MAPRE2 False True NA |
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2206 10985 GCN1L1 False True NA |
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2207 10987 COPS5 False True DNA Damage Recognition in GG-NER;Formation of TC-NER Pre-Incision Complex;Cargo recognition for clathrin-mediated endocytosis;Neddylation |
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2208 10988 METAP2 False True Inactivation, recovery and regulation of the phototransduction cascade |
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2209 10989 IMMT False True Cristae formation |
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2210 10992 SF3B2 False True mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway |
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2211 11007 CCDC85B False True NA |
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2212 11009 IL24 False True Interleukin-20 family signaling |
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2213 11010 GLIPR1 False True PPARA activates gene expression;Neutrophil degranulation |
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2214 11030 RBPMS False True NA |
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2215 11034 DSTN False True NA |
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2216 11040 PIM2 False True NA |
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2217 11047 ADRM1 False True UCH proteinases;Ub-specific processing proteases |
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2218 11052 CPSF6 False True Signaling by cytosolic FGFR1 fusion mutants;Signaling by FGFR1 in disease |
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2219 11059 WWP1 False True Downregulation of ERBB4 signaling;Stimuli-sensing channels;Regulation of RUNX2 expression and activity;Antigen processing: Ubiquitination & Proteasome degradation |
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2220 11067 C10orf10 False True NA |
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2221 11068 CYB561D2 False True NA |
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2222 11078 TRIOBP False True NA |
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2223 11079 RER1 False True NA |
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2224 11080 DNAJB4 False True NA |
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2225 11091 WDR5 False True PKMTs methylate histone lysines;HATs acetylate histones;HATs acetylate histones;RMTs methylate histone arginines;Activation of anterior HOX genes in hindbrain development during early embryogenesis;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Neddylation |
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2226 11100 HNRNPUL1 False True mRNA Splicing - Major Pathway |
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2227 11103 KRR1 False True rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol |
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2228 11124 FAF1 False True NA |
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2229 11133 KPTN False True NA |
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2230 11136 SLC7A9 False True Basigin interactions;Amino acid transport across the plasma membrane;Defective SLC7A9 causes cystinuria (CSNU) |
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2231 11140 CDC37 False True Signaling by ERBB2;Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants;Constitutive Signaling by EGFRvIII;Downregulation of ERBB2 signaling |
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2232 11144 DMC1 False True Meiotic recombination |
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2233 11146 GLMN False True Antigen processing: Ubiquitination & Proteasome degradation |
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2234 11149 BVES False True NA |
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2235 11155 LDB3 False True NA |
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2236 11160 ERLIN2 False True ABC-family proteins mediated transport;Signaling by FGFR1 in disease;Defective CFTR causes cystic fibrosis;Signaling by plasma membrane FGFR1 fusions |
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2237 11161 NA False True NA |
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2238 11170 FAM107A False True NA |
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2239 11184 MAP4K1 False True NA |
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2240 11187 PKP3 False True Keratinization;Formation of the cornified envelope |
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2241 11190 CEP250 False True Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;AURKA Activation by TPX2 |
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2242 11198 SUPT16H False True Formation of RNA Pol II elongation complex ;Formation of HIV elongation complex in the absence of HIV Tat;Formation of HIV-1 elongation complex containing HIV-1 Tat;Pausing and recovery of Tat-mediated HIV elongation;Tat-mediated HIV elongation arrest and recovery;Tat-mediated elongation of the HIV-1 transcript;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;RNA Polymerase II Pre-transcription Events;TP53 Regulates Transcription of DNA Repair Genes;Regulation of TP53 Activity through Phosphorylation;RNA Polymerase II Transcription Elongation |
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2243 11212 PROSC False True NA |
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2244 11213 IRAK3 False True MyD88:MAL(TIRAP) cascade initiated on plasma membrane;Interleukin-1 signaling |
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2245 11217 AKAP2 False True NA |
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2246 11222 MRPL3 False True Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation elongation;Mitochondrial translation termination |
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2247 11224 RPL35 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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2248 11226 GALNT6 False True O-linked glycosylation of mucins |
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2249 11228 RASSF8 False True NA |
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2250 11235 PDCD10 False True NA |
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2251 11243 PMF1 False True Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase |
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2252 11244 ZHX1 False True NA |
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2253 11267 SNF8 False True Endosomal Sorting Complex Required For Transport (ESCRT) |
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2254 11269 DDX19B False True NA |
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2255 11284 PNKP False True APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway |
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2256 11285 B4GALT7 False True A tetrasaccharide linker sequence is required for GAG synthesis;Defective B4GALT7 causes EDS, progeroid type |
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2257 11313 LYPLA2 False True L1CAM interactions |
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2258 11315 PARK7 False True SUMOylation of transcription cofactors |
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2259 11325 DDX42 False True mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway |
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2260 11329 STK38 False True NA |
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2261 11331 PHB2 False True Processing of SMDT1 |
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2262 11332 ACOT7 False True Mitochondrial Fatty Acid Beta-Oxidation |
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2263 11333 PDAP1 False True Neutrophil degranulation |
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2264 11335 CBX3 False True ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;RNA Polymerase I Chain Elongation;Transcriptional Regulation by E2F6 |
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2265 11338 U2AF2 False True Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing |
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2266 11339 OIP5 False True Deposition of new CENPA-containing nucleosomes at the centromere |
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2267 11343 MGLL False True Acyl chain remodeling of DAG and TAG;Triglyceride catabolism;Arachidonate production from DAG |
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2268 11344 TWF2 False True NA |
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2269 11346 SYNPO False True NA |
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2270 11622 NA False True NA |
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2271 12460 NA False True NA |
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2272 12550 Cdh1 False True NA |
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2273 13505 NA False True NA |
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2274 13510 NA False True NA |
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2275 14828 Hspa5 False True NA |
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2276 15481 NA False True NA |
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2277 15502 NA False True NA |
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2278 15505 Hsph1 False True NA |
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2279 15511 NA False True NA |
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2280 15512 NA False True NA |
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2281 15525 NA False True NA |
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2282 17248 Mdm4 False True NA |
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2283 17279 Melk False True NA |
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2284 18415 NA False True NA |
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2285 19015 Ppard False True NA |
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2286 19016 Pparg False True NA |
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2287 20655 Sod1 False True NA |
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2288 22802 NA False True Stimuli-sensing channels |
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2289 22803 XRN2 False True Association of TriC/CCT with target proteins during biosynthesis;Major pathway of rRNA processing in the nucleolus and cytosol |
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2290 22818 COPZ1 False True COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic |
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2291 22820 COPG1 False True COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic |
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2292 22822 PHLDA1 False True Interaction between PHLDA1 and AURKA |
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2293 22824 HSPA4L False True Regulation of HSF1-mediated heat shock response |
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2294 22826 DNAJC8 False True mRNA Splicing - Major Pathway |
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2295 22827 PUF60 False True mRNA Splicing - Major Pathway |
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2296 22828 NA False True NA |
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2297 22832 CEP162 False True Anchoring of the basal body to the plasma membrane |
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2298 22837 COBLL1 False True NA |
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2299 22841 RAB11FIP2 False True Vasopressin regulates renal water homeostasis via Aquaporins |
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2300 22848 AAK1 False True Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis |
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2301 22858 ICK False True NA |
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2302 22859 NA False True NA |
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2303 22868 FASTKD2 False True NA |
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2304 22872 SEC31A False True COPII-mediated vesicle transport;MHC class II antigen presentation;XBP1(S) activates chaperone genes;Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
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2305 22882 ZHX2 False True NA |
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2306 22907 DHX30 False True NA |
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2307 22908 SACM1L False True Synthesis of PIPs at the ER membrane;Synthesis of PIPs at the Golgi membrane |
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2308 22913 RALY False True NA |
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2309 22919 MAPRE1 False True Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;RHO GTPases Activate Formins;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;AURKA Activation by TPX2 |
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2310 22931 RAB18 False True Neutrophil degranulation;COPI-independent Golgi-to-ER retrograde traffic;RAB geranylgeranylation;RAB GEFs exchange GTP for GDP on RABs |
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2311 22938 SNW1 False True Pre-NOTCH Transcription and Translation;Pre-NOTCH Transcription and Translation;Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells;NOTCH1 Intracellular Domain Regulates Transcription;NOTCH1 Intracellular Domain Regulates Transcription;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Notch-HLH transcription pathway;mRNA Splicing - Major Pathway;RUNX3 regulates NOTCH signaling;RUNX3 regulates NOTCH signaling;NOTCH3 Intracellular Domain Regulates Transcription;NOTCH3 Intracellular Domain Regulates Transcription;NOTCH4 Intracellular Domain Regulates Transcription |
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2312 22948 CCT5 False True Prefoldin mediated transfer of substrate to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Folding of actin by CCT/TriC;Association of TriC/CCT with target proteins during biosynthesis;Association of TriC/CCT with target proteins during biosynthesis;BBSome-mediated cargo-targeting to cilium;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding |
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2313 22954 TRIM32 False True Regulation of innate immune responses to cytosolic DNA;Antigen processing: Ubiquitination & Proteasome degradation |
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2314 22974 TPX2 False True Regulation of TP53 Activity through Phosphorylation;AURKA Activation by TPX2 |
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2315 22980 TCF25 False True NA |
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2316 22981 NINL False True Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;AURKA Activation by TPX2 |
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2317 22985 ACIN1 False True Apoptotic cleavage of cellular proteins |
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2318 22992 KDM2A False True HDMs demethylate histones |
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2319 22994 CEP131 False True Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;AURKA Activation by TPX2 |
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2320 22995 CEP152 False True Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;AURKA Activation by TPX2 |
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2321 22998 LIMCH1 False True NA |
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2322 23011 RAB21 False True RAB geranylgeranylation;RAB GEFs exchange GTP for GDP on RABs |
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2323 23012 STK38L False True NA |
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2324 23015 NA False True NA |
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2325 23019 CNOT1 False True Deadenylation of mRNA;TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain |
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2326 23020 SNRNP200 False True mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway |
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2327 23022 PALLD False True NA |
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2328 23028 KDM1A False True HDACs deacetylate histones;HDMs demethylate histones;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Regulation of PTEN gene transcription;Estrogen-dependent gene expression;Factors involved in megakaryocyte development and platelet production |
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2329 23031 MAST3 False True NA |
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2330 23036 NA False True NA |
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2331 23039 XPO7 False True NA |
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2332 23042 PDXDC1 False True NA |
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2333 23047 PDS5B False True Separation of Sister Chromatids;Establishment of Sister Chromatid Cohesion;Cohesin Loading onto Chromatin;Resolution of Sister Chromatid Cohesion |
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2334 23052 ENDOD1 False True Platelet degranulation |
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2335 23064 SETX False True NA |
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2336 23072 HECW1 False True Degradation of DVL |
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2337 23074 NA False True NA |
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2338 23076 RRP1B False True NA |
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2339 23077 MYCBP2 False True NA |
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2340 23087 TRIM35 False True Interferon gamma signaling |
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2341 23090 ZNF423 False True NA |
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2342 23094 NA False True NA |
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2343 23095 KIF1B False True COPI-dependent Golgi-to-ER retrograde traffic;Kinesins |
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2344 23098 SARM1 False True MyD88-independent TLR4 cascade ;Toll Like Receptor 3 (TLR3) Cascade;Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon;IKK complex recruitment mediated by RIP1;TRAF6-mediated induction of TAK1 complex within TLR4 complex |
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2345 23099 ZBTB43 False True NA |
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2346 23108 NA False True Rap1 signalling |
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2347 23118 TAB2 False True Nuclear signaling by ERBB4;Nuclear signaling by ERBB4;NOD1/2 Signaling Pathway;Downstream TCR signaling;FCERI mediated NF-kB activation;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;activated TAK1 mediates p38 MAPK activation;JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1;TNFR1-induced NFkappaB signaling pathway;CLEC7A (Dectin-1) signaling;TICAM1,TRAF6-dependent induction of TAK1 complex;Interleukin-1 signaling;IRAK2 mediated activation of TAK1 complex;TRAF6-mediated induction of TAK1 complex within TLR4 complex;IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |
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2348 23122 CLASP2 False True Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;Role of ABL in ROBO-SLIT signaling;RHO GTPases Activate Formins;Mitotic Prometaphase |
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2349 23126 POGZ False True NA |
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2350 23132 RAD54L2 False True NA |
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2351 23136 EPB41L3 False True Neurexins and neuroligins |
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2352 23139 MAST2 False True NA |
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2353 23157 SEPT6 False True NA |
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2354 23164 MPRIP False True Signaling by BRAF and RAF fusions |
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2355 23165 NUP205 False True ISG15 antiviral mechanism;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Rev-mediated nuclear export of HIV RNA;Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Viral Messenger RNA Synthesis;NEP/NS2 Interacts with the Cellular Export Machinery;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;snRNP Assembly;SUMOylation of DNA damage response and repair proteins;SUMOylation of ubiquitinylation proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;SUMOylation of SUMOylation proteins;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins;Transcriptional regulation by small RNAs;tRNA processing in the nucleus |
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2356 23171 GPD1L False True Synthesis of PA |
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2357 23178 PASK False True NA |
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2358 23185 NA False True NA |
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2359 23189 NA False True Estrogen-dependent gene expression |
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2360 23191 CYFIP1 False True Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;VEGFA-VEGFR2 Pathway;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs;Neutrophil degranulation |
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2361 23193 GANAB False True N-glycan trimming in the ER and Calnexin/Calreticulin cycle;Calnexin/calreticulin cycle |
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2362 23197 FAF2 False True Neutrophil degranulation |
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2363 23198 PSME4 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Antigen processing: Ubiquitination & Proteasome degradation |
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2364 23203 PMPCA False True Mitochondrial protein import;Processing of SMDT1 |
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2365 23204 ARL6IP1 False True NA |
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2366 23211 NA False True NA |
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2367 23214 XPO6 False True NA |
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2368 23216 TBC1D1 False True Translocation of SLC2A4 (GLUT4) to the plasma membrane;Translocation of SLC2A4 (GLUT4) to the plasma membrane |
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2369 23218 NA False True Neutrophil degranulation |
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2370 23219 FBXO28 False True NA |
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2371 23220 DTX4 False True IRF3 mediated activation of type 1 IFN;Activated NOTCH1 Transmits Signal to the Nucleus;Activated NOTCH1 Transmits Signal to the Nucleus;Regulation of innate immune responses to cytosolic DNA;IRF3-mediated induction of type I IFN |
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2372 23221 RHOBTB2 False True Rho GTPase cycle |
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2373 23224 SYNE2 False True Meiotic synapsis |
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2374 23225 NUP210 False True ISG15 antiviral mechanism;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Rev-mediated nuclear export of HIV RNA;Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Viral Messenger RNA Synthesis;NEP/NS2 Interacts with the Cellular Export Machinery;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;snRNP Assembly;SUMOylation of DNA damage response and repair proteins;SUMOylation of ubiquitinylation proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;SUMOylation of SUMOylation proteins;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins;Transcriptional regulation by small RNAs;tRNA processing in the nucleus |
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2375 23234 DNAJC9 False True NA |
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2376 23237 ARC False True NA |
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2377 23242 COBL False True NA |
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2378 23244 PDS5A False True Separation of Sister Chromatids;Establishment of Sister Chromatid Cohesion;Cohesin Loading onto Chromatin;Resolution of Sister Chromatid Cohesion |
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2379 23248 NA False True RNA polymerase II transcribes snRNA genes;RNA polymerase II transcribes snRNA genes |
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2380 23255 MTCL1 False True NA |
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2381 23261 NA False True NA |
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2382 23262 PPIP5K2 False True Synthesis of pyrophosphates in the cytosol |
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2383 23264 ZC3H7B False True NA |
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2384 23276 KLHL18 False True NA |
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2385 23281 MTUS2 False True NA |
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2386 23288 IQCE False True Activation of SMO |
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2387 23291 FBXW11 False True Activation of NF-kappaB in B cells;Downstream TCR signaling;Regulation of PLK1 Activity at G2/M Transition;FCERI mediated NF-kB activation;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;NIK-->noncanonical NF-kB signaling;MAP3K8 (TPL2)-dependent MAPK1/3 activation;Neddylation;Antigen processing: Ubiquitination & Proteasome degradation |
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2388 23294 ANKS1A False True NA |
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2389 23303 KIF13B False True COPI-dependent Golgi-to-ER retrograde traffic;Kinesins |
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2390 23306 TMEM194A False True NA |
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2391 23310 NCAPD3 False True Condensation of Prophase Chromosomes |
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2392 23313 KIAA0930 False True NA |
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2393 23315 NA False True Sodium/Proton exchangers |
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2394 23317 DNAJC13 False True Neutrophil degranulation |
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2395 23321 TRIM2 False True Interferon gamma signaling |
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2396 23326 USP22 False True HATs acetylate histones;Ub-specific processing proteases |
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2397 23327 NEDD4L False True Budding and maturation of HIV virion;Downregulation of TGF-beta receptor signaling;Downregulation of SMAD2/3:SMAD4 transcriptional activity;Stimuli-sensing channels;Antigen processing: Ubiquitination & Proteasome degradation |
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2398 23328 SASH1 False True NA |
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2399 23332 CLASP1 False True Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Role of ABL in ROBO-SLIT signaling;Anchoring of the basal body to the plasma membrane;RHO GTPases Activate Formins;Mitotic Prometaphase;AURKA Activation by TPX2 |
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2400 23333 NA False True NA |
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2401 23334 SZT2 False True NA |
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2402 23345 SYNE1 False True Meiotic synapsis |
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2403 23350 U2SURP False True mRNA Splicing - Major Pathway |
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2404 23358 USP24 False True Ub-specific processing proteases |
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2405 23361 NA False True NA |
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2406 23363 OBSL1 False True Neddylation |
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2407 23367 LARP1 False True NA |
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2408 23373 CRTC1 False True Transcriptional activation of mitochondrial biogenesis;Circadian Clock;Circadian Clock |
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2409 23380 SRGAP2 False True Rho GTPase cycle;Inactivation of CDC42 and RAC1;RHO GTPases Activate Formins |
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2410 23384 NA False True NA |
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2411 23385 NCSTN False True Nuclear signaling by ERBB4;Degradation of the extracellular matrix;Regulated proteolysis of p75NTR;NRIF signals cell death from the nucleus;Activated NOTCH1 Transmits Signal to the Nucleus;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;NOTCH2 Activation and Transmission of Signal to the Nucleus;EPH-ephrin mediated repulsion of cells;Neutrophil degranulation;NOTCH3 Activation and Transmission of Signal to the Nucleus;NOTCH4 Activation and Transmission of Signal to the Nucleus;Noncanonical activation of NOTCH3;Amyloid fiber formation |
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2412 23386 NUDCD3 False True NA |
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2413 23387 SIK3 False True NA |
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2414 23392 KIAA0368 False True NA |
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2415 23397 NCAPH False True Condensation of Prometaphase Chromosomes;Condensation of Prometaphase Chromosomes |
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2416 23400 ATP13A2 False True Ion transport by P-type ATPases |
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2417 23405 DICER1 False True MicroRNA (miRNA) biogenesis;Small interfering RNA (siRNA) biogenesis |
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2418 23411 SIRT1 False True Regulation of HSF1-mediated heat shock response;Circadian Clock;SIRT1 negatively regulates rRNA expression;SIRT1 negatively regulates rRNA expression;Regulation of FOXO transcriptional activity by acetylation;Regulation of FOXO transcriptional activity by acetylation |
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2419 23418 NA False True NA |
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2420 23429 RYBP False True RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known;Transcriptional Regulation by E2F6 |
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2421 23431 AP4E1 False True Lysosome Vesicle Biogenesis;Golgi Associated Vesicle Biogenesis |
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2422 23435 TARDBP False True NA |
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2423 23446 NA False True Synthesis of PC;Transport of bile salts and organic acids, metal ions and amine compounds;Choline catabolism |
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2424 23450 SF3B3 False True mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway |
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2425 23451 SF3B1 False True B-WICH complex positively regulates rRNA expression;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway |
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2426 23468 CBX5 False True SUMOylation of chromatin organization proteins;Transcriptional Regulation by E2F6;Factors involved in megakaryocyte development and platelet production |
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2427 23469 NA False True NA |
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2428 23476 BRD4 False True NA |
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2429 23479 ISCU False True Mitochondrial iron-sulfur cluster biogenesis |
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2430 23481 PES1 False True Major pathway of rRNA processing in the nucleolus and cytosol |
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2431 23484 NA False True NA |
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2432 23499 MACF1 False True NA |
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2433 23503 ZFYVE26 False True NA |
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2434 23509 POFUT1 False True Pre-NOTCH Processing in the Endoplasmic Reticulum |
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2435 23513 SCRIB False True Asymmetric localization of PCP proteins |
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2436 23517 SKIV2L2 False True Major pathway of rRNA processing in the nucleolus and cytosol;mRNA Splicing - Major Pathway |
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2437 23521 RPL13A False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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2438 23524 SRRM2 False True mRNA Splicing - Major Pathway |
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2439 23526 NA False True Rho GTPase cycle;Neutrophil degranulation |
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2440 23527 ACAP2 False True NA |
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2441 23534 TNPO3 False True NA |
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2442 23543 RBFOX2 False True FGFR2 alternative splicing |
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2443 23566 LPAR3 False True G alpha (q) signalling events;G alpha (i) signalling events;Lysosphingolipid and LPA receptors |
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2444 23576 NA False True eNOS activation |
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2445 23581 CASP14 True True Formation of the cornified envelope |
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2446 23582 CCNDBP1 False True NA |
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2447 23588 KLHDC2 False True NA |
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2448 23589 CARHSP1 False True NA |
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2449 23592 NA False True Clearance of Nuclear Envelope Membranes from Chromatin;Initiation of Nuclear Envelope Reformation;Depolymerisation of the Nuclear Lamina |
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2450 23597 NA False True Mitochondrial Fatty Acid Beta-Oxidation |
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2451 23603 CORO1C False True NA |
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2452 23607 CD2AP False True Nephrin family interactions |
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2453 23617 TSSK2 False True NA |
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2454 23633 KPNA6 False True NA |
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2455 23636 NUP62 False True ISG15 antiviral mechanism;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Rev-mediated nuclear export of HIV RNA;Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Viral Messenger RNA Synthesis;NEP/NS2 Interacts with the Cellular Export Machinery;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;snRNP Assembly;SUMOylation of DNA damage response and repair proteins;SUMOylation of ubiquitinylation proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;SUMOylation of SUMOylation proteins;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins;Transcriptional regulation by small RNAs;tRNA processing in the nucleus |
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2456 23640 HSPBP1 False True NA |
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2457 23641 LDOC1 False True NA |
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2458 23644 EDC4 False True mRNA decay by 5' to 3' exoribonuclease |
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2459 23647 ARFIP2 False True Retrograde transport at the Trans-Golgi-Network |
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2460 23649 POLA2 False True Inhibition of replication initiation of damaged DNA by RB1/E2F1;Polymerase switching on the C-strand of the telomere;Telomere C-strand synthesis initiation;DNA replication initiation;Activation of the pre-replicative complex;Polymerase switching;Removal of the Flap Intermediate;Processive synthesis on the lagging strand |
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2461 23673 STX12 False True NA |
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2462 23677 SH3BP4 False True NA |
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2463 23678 SGK3 False True Stimuli-sensing channels |
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2464 23708 GSPT2 False True Eukaryotic Translation Termination;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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2465 23731 NA False True NA |
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2466 23760 NA False True PI and PC transport between ER and Golgi membranes |
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2467 23770 FKBP8 False True Ub-specific processing proteases |
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2468 23780 APOL2 False True NA |
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2469 23787 MTCH1 False True NA |
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2470 23788 MTCH2 False True NA |
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2471 24144 TFIP11 False True mRNA Splicing - Major Pathway |
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2472 24148 PRPF6 False True mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway |
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2473 25747 Ppara False True NA |
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2474 25776 CBY1 False True Deactivation of the beta-catenin transactivating complex |
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2475 25793 FBXO7 False True Neddylation;Antigen processing: Ubiquitination & Proteasome degradation |
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2476 25801 GCA False True Neutrophil degranulation |
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2477 25813 SAMM50 False True Mitochondrial protein import;Cristae formation |
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2478 25814 ATXN10 False True NA |
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2479 25816 TNFAIP8 False True PI Metabolism |
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2480 25820 ARIH1 False True ISG15 antiviral mechanism |
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2481 25822 DNAJB5 False True NA |
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2482 25824 PRDX5 False True Detoxification of Reactive Oxygen Species;TP53 Regulates Metabolic Genes |
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2483 25827 FBXL2 False True NA |
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2484 25831 HECTD1 False True Antigen processing: Ubiquitination & Proteasome degradation |
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2485 25843 MOB4 False True NA |
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2486 25864 ABHD14A False True NA |
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2487 25865 PRKD2 False True Sphingolipid de novo biosynthesis |
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2488 25873 RPL36 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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2489 25875 LETMD1 False True NA |
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2490 25885 POLR1A False True NoRC negatively regulates rRNA expression;B-WICH complex positively regulates rRNA expression;RNA Polymerase I Transcription Initiation;RNA Polymerase I Transcription Initiation;RNA Polymerase I Promoter Escape;RNA Polymerase I Chain Elongation;RNA Polymerase I Transcription Termination |
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2491 25898 RCHY1 False True Translesion Synthesis by POLH;Antigen processing: Ubiquitination & Proteasome degradation |
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2492 25900 IFFO1 False True NA |
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2493 25909 AHCTF1 False True Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase |
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parents:
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2494 25913 POT1 False True Meiotic synapsis;Packaging Of Telomere Ends;DNA Damage/Telomere Stress Induced Senescence |
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2495 25930 PTPN23 False True Interleukin-37 signaling |
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2496 25936 NSL1 False True Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase |
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2497 25937 WWTR1 False True Signaling by Hippo;YAP1- and WWTR1 (TAZ)-stimulated gene expression;YAP1- and WWTR1 (TAZ)-stimulated gene expression;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;Physiological factors;RUNX2 regulates osteoblast differentiation;RUNX3 regulates YAP1-mediated transcription |
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2498 25943 NA False True NA |
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2499 25957 PNISR False True NA |
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2500 25972 NA False True NA |
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2501 25984 NA True False Keratinization;Formation of the cornified envelope |
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2502 25994 HIGD1A False True Regulation of gene expression by Hypoxia-inducible Factor |
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2503 25996 REXO2 False True NA |
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2504 25998 IBTK False True NA |
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2505 26003 GORASP2 False True Golgi Cisternae Pericentriolar Stack Reorganization |
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2506 26020 LRP10 False True Retinoid metabolism and transport |
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2507 26030 NA False True NA |
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2508 26031 OSBPL3 False True Synthesis of bile acids and bile salts |
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2509 26032 NA False True NA |
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2510 26037 SIPA1L1 False True Neurexins and neuroligins |
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2511 26049 NA False True NA |
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2512 26052 DNM3 False True Toll Like Receptor 4 (TLR4) Cascade;Retrograde neurotrophin signalling;MHC class II antigen presentation;Recycling pathway of L1;Clathrin-mediated endocytosis |
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2513 26054 SENP6 False True NA |
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2514 26057 ANKRD17 False True NA |
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2515 26058 GIGYF2 False True NA |
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2516 26064 RAI14 False True NA |
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2517 26073 POLDIP2 False True NA |
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2518 26088 GGA1 False True TBC/RABGAPs;Amyloid fiber formation |
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2519 26091 HERC4 False True Antigen processing: Ubiquitination & Proteasome degradation |
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2520 26092 TOR1AIP1 False True NA |
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2521 26097 CHTOP False True Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA 3'-end processing |
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2522 26098 EDRF1 False True NA |
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2523 26099 SZRD1 False True NA |
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2524 26112 CCDC69 False True NA |
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2525 26121 PRPF31 False True mRNA Splicing - Major Pathway |
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2526 26128 KIAA1279 False True NA |
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2527 26130 GAPVD1 False True Clathrin-mediated endocytosis;RAB GEFs exchange GTP for GDP on RABs |
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2528 26135 SERBP1 False True NA |
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2529 26136 TES False True NA |
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2530 26137 NA False True NA |
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2531 26146 TRAF3IP1 False True Intraflagellar transport;Intraflagellar transport |
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2532 26150 RIBC2 False True NA |
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2533 26156 RSL1D1 False True NA |
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2534 26164 MTG2 False True NA |
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2535 26165 NA False True NA |
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2536 26168 SENP3 False True Major pathway of rRNA processing in the nucleolus and cytosol |
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2537 26190 FBXW2 False True Association of TriC/CCT with target proteins during biosynthesis;Neddylation;Antigen processing: Ubiquitination & Proteasome degradation |
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2538 26224 FBXL3 False True Association of TriC/CCT with target proteins during biosynthesis;Circadian Clock;Neddylation;Antigen processing: Ubiquitination & Proteasome degradation |
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2539 26227 PHGDH False True Serine biosynthesis |
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2540 26258 BLOC1S6 False True Golgi Associated Vesicle Biogenesis |
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2541 26260 FBXO25 False True NA |
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2542 26261 FBXO24 False True NA |
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2543 26267 FBXO10 False True Neddylation;Antigen processing: Ubiquitination & Proteasome degradation |
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2544 26268 FBXO9 False True Neddylation;Antigen processing: Ubiquitination & Proteasome degradation |
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2545 26270 FBXO6 False True Association of TriC/CCT with target proteins during biosynthesis;Neddylation;Antigen processing: Ubiquitination & Proteasome degradation |
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2546 26271 FBXO5 False True SCF-beta-TrCP mediated degradation of Emi1;Regulation of APC/C activators between G1/S and early anaphase;Phosphorylation of Emi1;Activation of E2F1 target genes at G1/S;Mitotic Metaphase/Anaphase Transition |
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2547 26272 FBXO4 False True Association of TriC/CCT with target proteins during biosynthesis;Neddylation;Antigen processing: Ubiquitination & Proteasome degradation |
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2548 26273 FBXO3 False True NA |
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2549 26275 HIBCH False True Branched-chain amino acid catabolism |
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2550 26278 SACS False True NA |
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2551 26285 NA False True Tight junction interactions |
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2552 26330 GAPDHS False True Association of TriC/CCT with target proteins during biosynthesis;Glycolysis;Gluconeogenesis |
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2553 26470 SEZ6L2 False True NA |
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2554 26502 NARF False True NA |
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2555 26509 MYOF False True NA |
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2556 26517 TIMM13 False True Mitochondrial protein import |
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2557 26524 LATS2 False True Signaling by Hippo |
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2558 26528 DAZAP1 False True NA |
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2559 26576 SRPK3 False True NA |
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2560 26578 OSTF1 False True Neutrophil degranulation |
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2561 26589 MRPL46 False True Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation elongation;Mitochondrial translation termination |
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2562 26750 RPS6KC1 False True NA |
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2563 26973 CHORDC1 False True NA |
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2564 26984 SEC22A False True COPII-mediated vesicle transport |
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2565 26985 AP3M1 False True Association of TriC/CCT with target proteins during biosynthesis |
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2566 26986 PABPC1 False True L13a-mediated translational silencing of Ceruloplasmin expression;Deadenylation of mRNA;AUF1 (hnRNP D0) binds and destabilizes mRNA;Translation initiation complex formation;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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2567 26993 AKAP8L False True NA |
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2568 26998 NA False True NA |
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2569 26999 CYFIP2 False True Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;VEGFA-VEGFR2 Pathway;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs |
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2570 27000 DNAJC2 False True Regulation of HSF1-mediated heat shock response |
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2571 27018 NGFRAP1 False True NADE modulates death signalling |
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2572 27040 LAT False True GPVI-mediated activation cascade;Generation of second messenger molecules;DAP12 signaling;Fc epsilon receptor (FCERI) signaling;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;FCERI mediated Ca+2 mobilization;RAF/MAP kinase cascade |
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2573 27044 SND1 False True Signaling by BRAF and RAF fusions |
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2574 27069 GHITM False True NA |
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2575 27072 VPS41 False True NA |
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2576 27076 LYPD3 True True Post-translational modification: synthesis of GPI-anchored proteins |
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2577 27095 TRAPPC3 False True COPII-mediated vesicle transport;RAB GEFs exchange GTP for GDP on RABs |
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2578 27101 CACYBP False True NA |
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2579 27102 EIF2AK1 False True NA |
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2580 27107 NA False True NA |
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2581 27109 NA False True Formation of ATP by chemiosmotic coupling;Cristae formation |
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2582 27113 BBC3 False True BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members;Activation of PUMA and translocation to mitochondria;TP53 Regulates Transcription of Genes Involved in Cytochrome C Release;FOXO-mediated transcription of cell death genes |
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2583 27128 CYTH4 False True Intra-Golgi traffic |
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2584 27143 NA False True NA |
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2585 27153 NA False True Generic Transcription Pathway |
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2586 27229 TUBGCP4 False True Recruitment of mitotic centrosome proteins and complexes;Recruitment of NuMA to mitotic centrosomes |
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2587 27230 SERP1 False True XBP1(S) activates chaperone genes |
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2588 27236 ARFIP1 False True NA |
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2589 27237 ARHGEF16 False True NRAGE signals death through JNK;Rho GTPase cycle;G alpha (12/13) signalling events |
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2590 27238 GPKOW False True mRNA Splicing - Major Pathway |
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2591 27245 AHDC1 False True NA |
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2592 27246 RNF115 False True Antigen processing: Ubiquitination & Proteasome degradation |
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2593 27247 NFU1 False True NA |
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2594 27248 ERLEC1 False True ABC-family proteins mediated transport;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Defective CFTR causes cystic fibrosis |
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2595 27250 PDCD4 False True Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation |
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2596 27258 LSM3 False True mRNA decay by 5' to 3' exoribonuclease;mRNA decay by 5' to 3' exoribonuclease;mRNA Splicing - Major Pathway |
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2597 27295 NA False True NA |
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2598 27316 RBMX False True mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA |
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2599 27330 RPS6KA6 False True Recycling pathway of L1;CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling;RSK activation;RSK activation |
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2600 27332 ZNF638 False True Transcriptional regulation of white adipocyte differentiation |
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2601 27335 EIF3K False True L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit |
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2602 27339 PRPF19 False True Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;mRNA Splicing - Major Pathway |
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2603 27347 STK39 False True NA |
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2604 27430 MAT2B False True Methylation;Ub-specific processing proteases |
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2605 28916 NA False True NA |
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2606 28952 CCDC22 False True Neddylation |
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2607 28954 REM1 False True NA |
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2608 28957 MRPS28 False True Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation elongation;Mitochondrial translation termination |
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2609 28960 DCPS False True mRNA decay by 3' to 5' exoribonuclease |
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2610 28969 BZW2 False True NA |
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2611 28970 C11orf54 False True NA |
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2612 28972 NA False True SRP-dependent cotranslational protein targeting to membrane;Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1);Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP);Synthesis, secretion, and deacylation of Ghrelin |
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2613 28973 MRPS18B False True Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation elongation;Mitochondrial translation termination |
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2614 28978 TMEM14A False True NA |
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2615 28982 NA False True Iron uptake and transport |
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2616 28985 MCTS1 False True NA |
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2617 29058 NA False True NA |
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2618 29082 CHMP4A False True Budding and maturation of HIV virion;Macroautophagy;Endosomal Sorting Complex Required For Transport (ESCRT) |
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2619 29099 COMMD9 False True Neutrophil degranulation;Neddylation |
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2620 29100 NA False True NA |
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2621 29104 N6AMT1 False True Methylation;Eukaryotic Translation Termination |
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2622 29109 FHOD1 False True NA |
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2623 29110 TBK1 False True IRF3 mediated activation of type 1 IFN;IRF3 mediated activation of type 1 IFN;Regulation of innate immune responses to cytosolic DNA;STAT6-mediated induction of chemokines;IRF3-mediated induction of type I IFN;Interleukin-37 signaling;TICAM1-dependent activation of IRF3/IRF7;TRAF3-dependent IRF activation pathway;TRAF6 mediated IRF7 activation;Negative regulators of DDX58/IFIH1 signaling;Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon |
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2624 29114 TAGLN3 False True NA |
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2625 29115 SAP30BP False True NoRC negatively regulates rRNA expression |
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2626 29119 CTNNA3 False True NA |
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2627 29127 RACGAP1 False True Rho GTPase cycle;MHC class II antigen presentation;COPI-dependent Golgi-to-ER retrograde traffic;Kinesins |
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2628 29128 UHRF1 False True DNA methylation |
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2629 29763 PACSIN3 False True Clathrin-mediated endocytosis |
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2630 29766 TMOD3 False True Striated Muscle Contraction |
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2631 29785 CYP2S1 False True Miscellaneous substrates;Xenobiotics;CYP2E1 reactions |
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2632 29789 OLA1 False True Platelet degranulation |
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2633 29843 SENP1 False True SUMO is proteolytically processed |
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2634 29882 ANAPC2 False True Inactivation of APC/C via direct inhibition of the APC/C complex;APC/C:Cdc20 mediated degradation of Cyclin B;Autodegradation of Cdh1 by Cdh1:APC/C;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase;Regulation of APC/C activators between G1/S and early anaphase;APC/C:Cdc20 mediated degradation of mitotic proteins;Phosphorylation of the APC/C;APC-Cdc20 mediated degradation of Nek2A;Separation of Sister Chromatids;Senescence-Associated Secretory Phenotype (SASP);CDK-mediated phosphorylation and removal of Cdc6;Antigen processing: Ubiquitination & Proteasome degradation |
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2635 29889 GNL2 False True NA |
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2636 29894 CPSF1 False True Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA Derived from an Intronless Transcript;tRNA processing in the nucleus;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Processing of Intronless Pre-mRNAs |
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2637 29896 TRA2A False True NA |
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2638 29926 GMPPA False True Synthesis of GDP-mannose |
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2639 29927 SEC61A1 False True ER-Phagosome pathway;SRP-dependent cotranslational protein targeting to membrane;XBP1(S) activates chaperone genes |
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2640 29941 PKN3 False True RHO GTPases activate PKNs |
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2641 29944 NA False True NA |
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2642 29950 SERTAD1 False True NA |
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2643 29951 NA False True NA |
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2644 29968 PSAT1 False True Serine biosynthesis |
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2645 29978 UBQLN2 False True Cargo recognition for clathrin-mediated endocytosis |
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2646 29979 UBQLN1 False True Cargo recognition for clathrin-mediated endocytosis |
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2647 29980 DONSON False True NA |
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2648 30000 TNPO2 False True NA |
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2649 30011 SH3KBP1 False True EGFR downregulation;Negative regulation of MET activity;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Reelin signalling pathway;InlB-mediated entry of Listeria monocytogenes into host cell;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
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2650 30817 NA False True Class B/2 (Secretin family receptors) |
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2651 30827 CXXC1 False True XBP1(S) activates chaperone genes |
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2652 30834 ZNRD1 False True NoRC negatively regulates rRNA expression;B-WICH complex positively regulates rRNA expression;RNA Polymerase I Transcription Initiation;RNA Polymerase I Transcription Initiation;RNA Polymerase I Promoter Escape;RNA Polymerase I Chain Elongation;RNA Polymerase I Transcription Termination |
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2653 30849 NA False True PI3K Cascade;Macroautophagy;Synthesis of PIPs at the Golgi membrane;Synthesis of PIPs at the early endosome membrane;Synthesis of PIPs at the late endosome membrane;Toll Like Receptor 9 (TLR9) Cascade;RHO GTPases Activate NADPH Oxidases |
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2654 30850 CDR2L False True NA |
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2655 30851 TAX1BP3 False True RHO GTPases Activate Rhotekin and Rhophilins |
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2656 30968 STOML2 False True Processing of SMDT1 |
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2657 33226 NA False True NA |
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2658 50488 MINK1 False True Oxidative Stress Induced Senescence |
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2659 50489 CD207 False True Cross-presentation of soluble exogenous antigens (endosomes);Cross-presentation of soluble exogenous antigens (endosomes) |
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2660 50515 NA False True Chondroitin sulfate biosynthesis |
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2661 50717 DCAF8 False True Neddylation |
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2662 50809 HP1BP3 False True NA |
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2663 50855 PARD6A False True TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);Tight junction interactions;Asymmetric localization of PCP proteins |
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2664 50856 NA False True Dectin-2 family |
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2665 50945 TBX22 False True NA |
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2666 51002 TPRKB False True tRNA modification in the nucleus and cytosol |
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2667 51003 MED31 False True PPARA activates gene expression;Generic Transcription Pathway;Transcriptional regulation of white adipocyte differentiation;Transcriptional regulation of white adipocyte differentiation |
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2668 51005 AMDHD2 False True Synthesis of UDP-N-acetyl-glucosamine |
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2669 51008 ASCC1 False True ALKBH3 mediated reversal of alkylation damage |
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2670 51009 DERL2 False True ABC-family proteins mediated transport;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Defective CFTR causes cystic fibrosis;ER Quality Control Compartment (ERQC) |
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2671 51011 FAHD2A False True NA |
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2672 51015 ISOC1 False True NA |
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2673 51019 CCDC53 False True NA |
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2674 51026 GOLT1B False True NA |
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2675 51031 GLOD4 False True NA |
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2676 51035 UBXN1 False True N-glycan trimming in the ER and Calnexin/Calreticulin cycle |
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2677 51061 TXNDC11 False True NA |
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2678 51068 NMD3 False True NA |
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2679 51077 FCF1 False True rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol |
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2680 51078 THAP4 False True NA |
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2681 51086 TNNI3K False True NA |
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2682 51090 PLLP False True NA |
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2683 51100 SH3GLB1 False True NA |
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2684 51110 LACTB2 False True NA |
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2685 51119 SBDS False True NA |
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2686 51121 RPL26L1 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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2687 51127 TRIM17 False True Interferon gamma signaling |
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2688 51130 ASB3 False True Neddylation;Antigen processing: Ubiquitination & Proteasome degradation |
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2689 51133 KCTD3 False True NA |
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2690 51134 CEP83 False True Anchoring of the basal body to the plasma membrane |
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2691 51141 INSIG2 False True Regulation of cholesterol biosynthesis by SREBP (SREBF) |
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2692 51142 CHCHD2 False True Mitochondrial protein import |
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2693 51148 CERCAM False True NA |
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2694 51150 SDF4 False True NA |
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2695 51155 HN1 False True NA |
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2696 51196 PLCE1 False True Synthesis of IP3 and IP4 in the cytosol |
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2697 51200 CPA4 True True NA |
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2698 51207 DUSP13 False True NA |
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2699 51218 GLRX5 False True Mitochondrial iron-sulfur cluster biogenesis |
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2700 51225 ABI3 False True NA |
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2701 51248 PDZD11 False True Biotin transport and metabolism;Vitamin B5 (pantothenate) metabolism;Transport of vitamins, nucleosides, and related molecules;Ion influx/efflux at host-pathogen interface;Ion transport by P-type ATPases |
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2702 51253 MRPL37 False True Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation elongation;Mitochondrial translation termination |
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2703 51255 RNF181 False True E3 ubiquitin ligases ubiquitinate target proteins |
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2704 51267 CLEC1A False True NA |
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2705 51270 TFDP3 False True NA |
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2706 51271 UBAP1 False True Budding and maturation of HIV virion;Membrane binding and targetting of GAG proteins;Endosomal Sorting Complex Required For Transport (ESCRT) |
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2707 51295 ECSIT False True MyD88:MAL(TIRAP) cascade initiated on plasma membrane;Complex I biogenesis;TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation;MyD88 cascade initiated on plasma membrane |
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2708 51306 NA False True Rho GTPase cycle |
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2709 51307 FAM53C False True NA |
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2710 51317 PHF21A False True HDACs deacetylate histones;Factors involved in megakaryocyte development and platelet production |
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2711 51322 WAC False True E3 ubiquitin ligases ubiquitinate target proteins |
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2712 51324 SPG21 False True NA |
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2713 51340 CRNKL1 False True mRNA Splicing - Major Pathway |
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2714 51343 FZR1 False True Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase;Regulation of APC/C activators between G1/S and early anaphase;Phosphorylation of Emi1;Senescence-Associated Secretory Phenotype (SASP);CDK-mediated phosphorylation and removal of Cdc6;Cyclin A:Cdk2-associated events at S phase entry;Antigen processing: Ubiquitination & Proteasome degradation |
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2715 51347 TAOK3 False True NA |
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2716 51360 MBTPS2 False True Regulation of cholesterol biosynthesis by SREBP (SREBF);ATF6 (ATF6-alpha) activates chaperones;CREB3 factors activate genes;CREB3 factors activate genes;Assembly of active LPL and LIPC lipase complexes |
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2717 51371 POMP False True NA |
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2718 51377 UCHL5 False True Downregulation of TGF-beta receptor signaling;UCH proteinases;UCH proteinases |
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2719 51380 NA False True Degradation of cysteine and homocysteine |
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2720 51390 AIG1 False True NA |
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2721 51399 TRAPPC4 False True COPII-mediated vesicle transport;Syndecan interactions;RAB GEFs exchange GTP for GDP on RABs |
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2722 51400 PPME1 False True Cyclin A/B1/B2 associated events during G2/M transition |
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2723 51421 AMOTL2 False True Signaling by Hippo |
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2724 51434 ANAPC7 False True Inactivation of APC/C via direct inhibition of the APC/C complex;APC/C:Cdc20 mediated degradation of Cyclin B;Autodegradation of Cdh1 by Cdh1:APC/C;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase;Regulation of APC/C activators between G1/S and early anaphase;APC/C:Cdc20 mediated degradation of mitotic proteins;Phosphorylation of the APC/C;APC-Cdc20 mediated degradation of Nek2A;Separation of Sister Chromatids;Senescence-Associated Secretory Phenotype (SASP);CDK-mediated phosphorylation and removal of Cdc6;Antigen processing: Ubiquitination & Proteasome degradation |
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2725 51435 SCARA3 False True NA |
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2726 51455 REV1 False True Translesion synthesis by REV1;Translesion synthesis by POLK;Translesion synthesis by POLI;Termination of translesion DNA synthesis |
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2727 51474 LIMA1 False True NA |
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2728 51477 ISYNA1 False True Synthesis of IP2, IP, and Ins in the cytosol |
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2729 51490 C9orf114 False True NA |
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2730 51506 UFC1 False True NA |
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2731 51512 GTSE1 False True G2/M Checkpoints;The role of GTSE1 in G2/M progression after G2 checkpoint |
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2732 51514 DTL False True Recognition of DNA damage by PCNA-containing replication complex;Neddylation |
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2733 51517 NCKIPSD False True Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs |
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2734 51520 LARS False True SeMet incorporation into proteins;Cytosolic tRNA aminoacylation |
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2735 51522 TMEM14C False True NA |
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2736 51526 OSER1 False True NA |
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2737 51530 ZC3HC1 False True NA |
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2738 51531 C9orf156 False True NA |
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2739 51535 PPHLN1 False True NA |
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2740 51540 SCLY False True Metabolism of ingested SeMet, Sec, MeSec into H2Se |
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2741 51552 RAB14 False True Translocation of SLC2A4 (GLUT4) to the plasma membrane;Synthesis of PIPs at the plasma membrane;Neutrophil degranulation;RAB geranylgeranylation;RAB GEFs exchange GTP for GDP on RABs |
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2742 51560 RAB6B False True COPI-independent Golgi-to-ER retrograde traffic;Retrograde transport at the Trans-Golgi-Network;TBC/RABGAPs;RAB geranylgeranylation;RAB GEFs exchange GTP for GDP on RABs |
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2743 51564 HDAC7 False True NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;SUMOylation of DNA damage response and repair proteins;Regulation of PTEN gene transcription |
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2744 51569 UFM1 False True NA |
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2745 51571 FAM49B False True Platelet degranulation |
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2746 51574 LARP7 False True NA |
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2747 51588 PIAS4 False True Vitamin D (calciferol) metabolism;SUMOylation of DNA damage response and repair proteins;SUMOylation of transcription factors;SUMOylation of ubiquitinylation proteins;SUMOylation of transcription cofactors;SUMOylation of SUMOylation proteins;SUMOylation of intracellular receptors;SUMOylation of intracellular receptors;SUMOylation of DNA replication proteins;SUMOylation of immune response proteins;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Processing of DNA double-strand break ends;G2/M DNA damage checkpoint |
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2748 51593 SRRT False True RNA polymerase II transcribes snRNA genes;mRNA Splicing - Major Pathway |
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2749 51594 NA False True COPI-dependent Golgi-to-ER retrograde traffic |
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2750 51596 CUTA False True NA |
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parents:
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2751 51599 LSR False True LDL clearance;VLDL clearance |
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2752 51602 NOP58 False True SUMOylation of RNA binding proteins;rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol |
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2753 51603 METTL13 False True NA |
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2754 51606 ATP6V1H False True ROS, RNS production in phagocytes;Nef Mediated CD4 Down-regulation;Nef Mediated CD8 Down-regulation;Insulin receptor recycling;Transferrin endocytosis and recycling;Ion channel transport |
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2755 51611 DPH5 False True Synthesis of diphthamide-EEF2 |
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2756 51629 NA False True NA |
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2757 51631 LUC7L2 False True NA |
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2758 51637 C14orf166 False True tRNA processing in the nucleus |
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2759 51639 SF3B6 False True mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway |
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2760 51649 MRPS23 False True Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation elongation;Mitochondrial translation termination |
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2761 51651 PTRH2 False True Ub-specific processing proteases |
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2762 51659 GINS2 False True Unwinding of DNA;Unwinding of DNA |
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2763 51661 FKBP7 False True NA |
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2764 51663 ZFR False True NA |
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2765 51666 ASB4 False True Neddylation;Antigen processing: Ubiquitination & Proteasome degradation |
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2766 51676 ASB2 False True Neddylation;Antigen processing: Ubiquitination & Proteasome degradation |
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2767 51692 CPSF3 False True Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA Derived from an Intronless Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Processing of Intronless Pre-mRNAs |
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2768 51714 NA False True NA |
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2769 51725 FBXO40 False True Neddylation;Antigen processing: Ubiquitination & Proteasome degradation |
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2770 51726 DNAJB11 False True XBP1(S) activates chaperone genes |
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2771 51735 RAPGEF6 False True NA |
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2772 51741 WWOX False True Nuclear signaling by ERBB4;Negative regulation of activity of TFAP2 (AP-2) family transcription factors;Activation of the TFAP2 (AP-2) family of transcription factors |
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2773 51747 LUC7L3 False True NA |
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2774 51752 ERAP1 False True Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
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2775 51759 C9orf78 False True NA |
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2776 51763 INPP5K False True Synthesis of PIPs at the plasma membrane |
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2777 51776 ZAK False True NA |
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2778 51778 MYOZ2 False True NA |
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2779 51780 KDM3B False True HDMs demethylate histones |
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2780 51806 NA True False Neutrophil degranulation |
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2781 53371 NUP54 False True ISG15 antiviral mechanism;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Rev-mediated nuclear export of HIV RNA;Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Viral Messenger RNA Synthesis;NEP/NS2 Interacts with the Cellular Export Machinery;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;snRNP Assembly;SUMOylation of DNA damage response and repair proteins;SUMOylation of ubiquitinylation proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;SUMOylation of SUMOylation proteins;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins;Transcriptional regulation by small RNAs;tRNA processing in the nucleus |
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2782 53615 MBD3 False True HDACs deacetylate histones;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;Regulation of TP53 Activity through Acetylation;RNA Polymerase I Transcription Initiation;Regulation of PTEN gene transcription;Regulation of PTEN gene transcription |
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2783 53635 PTOV1 False True NA |
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2784 53826 FXYD6 False True Ion homeostasis;Ion transport by P-type ATPases |
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2785 53838 C11orf24 False True NA |
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2786 53918 PELO False True NA |
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2787 53938 PPIL3 False True mRNA Splicing - Major Pathway |
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2788 53981 CPSF2 False True Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA Derived from an Intronless Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Processing of Intronless Pre-mRNAs |
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2789 54065 SMIM11 False True NA |
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2790 54107 POLE3 False True Recognition of DNA damage by PCNA-containing replication complex;Telomere C-strand synthesis initiation;PCNA-Dependent Long Patch Base Excision Repair;Termination of translesion DNA synthesis;HDR through Homologous Recombination (HRR);Gap-filling DNA repair synthesis and ligation in GG-NER;Dual Incision in GG-NER;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;DNA replication initiation;Activation of the pre-replicative complex |
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2791 54187 NANS False True Sialic acid metabolism |
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2792 54205 CYCS False True Release of apoptotic factors from the mitochondria;Formation of apoptosome;Activation of caspases through apoptosome-mediated cleavage;SMAC (DIABLO) binds to IAPs ;SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ;Transcriptional activation of mitochondrial biogenesis;Detoxification of Reactive Oxygen Species;TP53 Regulates Metabolic Genes;Respiratory electron transport;Regulation of the apoptosome activity;Regulation of the apoptosome activity |
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2793 54206 ERRFI1 False True NA |
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2794 54431 DNAJC10 False True NA |
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2795 54432 YIPF1 False True NA |
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2796 54433 GAR1 False True rRNA modification in the nucleus and cytosol |
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2797 54439 RBM27 False True NA |
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2798 54443 ANLN False True NA |
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2799 54458 PRR13 False True NA |
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2800 54460 MRPS21 False True Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation elongation;Mitochondrial translation termination |
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2801 54461 FBXW5 False True Association of TriC/CCT with target proteins during biosynthesis;Neddylation;Antigen processing: Ubiquitination & Proteasome degradation |
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2802 54468 MIOS False True NA |
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2803 54474 KRT20 False True Keratinization;Formation of the cornified envelope |
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2804 54478 FAM64A False True NA |
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2805 54507 ADAMTSL4 False True Defective B3GALTL causes Peters-plus syndrome (PpS);O-glycosylation of TSR domain-containing proteins |
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2806 54509 RHOF False True Rho GTPase cycle;Neutrophil degranulation |
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2807 54512 EXOSC4 False True ATF4 activates genes;mRNA decay by 3' to 5' exoribonuclease;Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA;Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA;KSRP (KHSRP) binds and destabilizes mRNA;Major pathway of rRNA processing in the nucleolus and cytosol |
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2808 54517 PUS7 False True tRNA modification in the nucleus and cytosol |
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2809 54535 CCHCR1 False True NA |
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2810 54536 EXOC6 False True Translocation of SLC2A4 (GLUT4) to the plasma membrane;Insulin processing;VxPx cargo-targeting to cilium |
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2811 54539 NDUFB11 False True Respiratory electron transport;Complex I biogenesis |
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2812 54541 DDIT4 False True TP53 Regulates Metabolic Genes |
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2813 54552 GNL3L False True NA |
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2814 54566 EPB41L4B False True NA |
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2815 54583 EGLN1 False True Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha |
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2816 54585 LZTFL1 False True BBSome-mediated cargo-targeting to cilium |
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2817 54617 INO80 False True UCH proteinases;DNA Damage Recognition in GG-NER |
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2818 54623 PAF1 False True Formation of RNA Pol II elongation complex ;RNA Polymerase II Pre-transcription Events;RNA Polymerase II Transcription Elongation;E3 ubiquitin ligases ubiquitinate target proteins |
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2819 54677 CROT False True Beta-oxidation of pristanoyl-CoA;Peroxisomal protein import;Peroxisomal protein import |
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2820 54708 MARCH5 False True NA |
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2821 54737 MPHOSPH8 False True NA |
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2822 54749 NA False True NA |
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2823 54751 FBLIM1 False True Cell-extracellular matrix interactions |
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2824 54778 RNF111 False True Downregulation of SMAD2/3:SMAD4 transcriptional activity;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;Formation of Incision Complex in GG-NER;Antigen processing: Ubiquitination & Proteasome degradation |
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2825 54780 NSMCE4A False True SUMOylation of DNA damage response and repair proteins |
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2826 54788 DNAJB12 False True NA |
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2827 54814 QPCTL False True NA |
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2828 54826 NA False True NA |
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2829 54850 FBXL12 False True Neddylation;Antigen processing: Ubiquitination & Proteasome degradation |
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2830 54852 PAQR5 False True NA |
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2831 54859 ELP6 False True HATs acetylate histones |
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2832 54867 NA False True NA |
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2833 54870 QRICH1 False True NA |
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2834 54888 NSUN2 False True tRNA modification in the nucleus and cytosol;tRNA modification in the nucleus and cytosol |
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2835 54901 CDKAL1 False True tRNA modification in the nucleus and cytosol |
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2836 54903 MKS1 False True Hedgehog 'off' state;Anchoring of the basal body to the plasma membrane |
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2837 54919 DNAAF5 False True NA |
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2838 54936 ADPRHL2 False True POLB-Dependent Long Patch Base Excision Repair |
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2839 54948 MRPL16 False True Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation elongation;Mitochondrial translation termination |
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2840 54955 C1orf109 False True NA |
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2841 54962 TIPIN False True Processing of DNA double-strand break ends |
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2842 54971 BANP False True Regulation of TP53 Activity through Association with Co-factors |
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2843 54982 CLN6 False True NA |
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2844 54987 C1orf123 False True NA |
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2845 55002 TMCO3 False True NA |
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2846 55008 HERC6 False True Antigen processing: Ubiquitination & Proteasome degradation |
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2847 55010 PARPBP False True NA |
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2848 55011 PIH1D1 False True NA |
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2849 55012 PPP2R3C False True NA |
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2850 55027 NA False True NA |
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2851 55030 FBXO34 False True NA |
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2852 55048 VPS37C False True Budding and maturation of HIV virion;Membrane binding and targetting of GAG proteins;Endosomal Sorting Complex Required For Transport (ESCRT) |
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2853 55052 MRPL20 False True Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation elongation;Mitochondrial translation termination |
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2854 55066 NA False True Regulation of pyruvate dehydrogenase (PDH) complex |
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2855 55070 DET1 False True Antigen processing: Ubiquitination & Proteasome degradation |
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2856 55075 UACA False True Regulation of the apoptosome activity |
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2857 55092 TMEM51 False True NA |
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2858 55093 WDYHV1 False True NA |
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2859 55094 GPATCH1 False True NA |
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2860 55095 SAMD4B False True NA |
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2861 55100 WDR70 False True NA |
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2862 55103 RALGPS2 False True NA |
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2863 55108 BSDC1 False True NA |
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2864 55114 ARHGAP17 False True Rho GTPase cycle |
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2865 55119 NA False True NA |
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2866 55122 AKIRIN2 False True NA |
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2867 55124 PIWIL2 False True PIWI-interacting RNA (piRNA) biogenesis |
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2868 55125 CEP192 False True Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;AURKA Activation by TPX2 |
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2869 55127 HEATR1 False True rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol |
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2870 55139 ANKZF1 False True NA |
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2871 55143 CDCA8 False True Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;SUMOylation of DNA replication proteins;RHO GTPases Activate Formins;Mitotic Prometaphase |
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2872 55149 MTPAP False True NA |
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2873 55153 NA False True NA |
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2874 55154 MSTO1 False True NA |
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2875 55159 RFWD3 False True NA |
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2876 55165 CEP55 False True NA |
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2877 55167 MSL2 False True HATs acetylate histones |
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2878 55177 RMDN3 False True NA |
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2879 55179 NA False True NA |
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2880 55183 RIF1 False True Nonhomologous End-Joining (NHEJ) |
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2881 55192 DNAJC17 False True NA |
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2882 55197 RPRD1A False True RNA polymerase II transcribes snRNA genes;RNA polymerase II transcribes snRNA genes |
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2883 55210 ATAD3A False True NA |
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2884 55213 RCBTB1 False True NA |
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2885 55223 TRIM62 False True Interferon gamma signaling |
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2886 55229 PANK4 False True Coenzyme A biosynthesis |
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2887 55231 CCDC87 False True NA |
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2888 55236 UBA6 False True Synthesis of active ubiquitin: roles of E1 and E2 enzymes;Synthesis of active ubiquitin: roles of E1 and E2 enzymes;Antigen processing: Ubiquitination & Proteasome degradation |
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2889 55238 SLC38A7 False True NA |
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2890 55257 MRGBP False True HATs acetylate histones |
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2891 55272 IMP3 False True rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol |
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2892 55276 PGM2 False True Glycogen synthesis;Neutrophil degranulation;Glycogen breakdown (glycogenolysis);Galactose catabolism;Pentose phosphate pathway |
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2893 55281 TMEM140 False True NA |
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2894 55290 BRF2 False True RNA Polymerase III Abortive And Retractive Initiation;RNA Polymerase III Transcription Initiation From Type 3 Promoter;RNA Polymerase III Transcription Initiation From Type 3 Promoter |
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2895 55294 FBXW7 False True NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Association of TriC/CCT with target proteins during biosynthesis;Regulation of RUNX2 expression and activity;Neddylation;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation |
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2896 55295 NA False True NA |
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2897 55324 ABCF3 False True NA |
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2898 55326 NA False True Synthesis of PA |
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2899 55336 FBXL8 False True Neddylation;Antigen processing: Ubiquitination & Proteasome degradation |
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2900 55351 NA False True NA |
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2901 55353 LAPTM4B False True NA |
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2902 55359 NA False True NA |
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2903 55379 LRRC59 False True NA |
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2904 55388 MCM10 False True Activation of ATR in response to replication stress;Activation of the pre-replicative complex |
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2905 55454 CSGALNACT2 False True Chondroitin sulfate biosynthesis |
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2906 55466 DNAJA4 False True HSP90 chaperone cycle for steroid hormone receptors (SHR) |
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2907 55505 NOP10 False True rRNA modification in the nucleus and cytosol |
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2908 55510 DDX43 False True NA |
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2909 55521 TRIM36 False True Antigen processing: Ubiquitination & Proteasome degradation |
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2910 55561 CDC42BPG False True NA |
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2911 55568 NA False True O-linked glycosylation of mucins |
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2912 55585 UBE2Q1 False True Antigen processing: Ubiquitination & Proteasome degradation |
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2913 55588 MED29 False True PPARA activates gene expression;Transcriptional regulation of white adipocyte differentiation;Transcriptional regulation of white adipocyte differentiation |
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2914 55589 NA False True NA |
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2915 55602 CDKN2AIP False True NA |
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2916 55609 NA False True NA |
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2917 55611 OTUB1 False True Ub-specific processing proteases;Ovarian tumor domain proteases |
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2918 55632 G2E3 False True NA |
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2919 55644 OSGEP False True tRNA modification in the nucleus and cytosol |
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2920 55651 NHP2 False True Telomere Extension By Telomerase;rRNA modification in the nucleus and cytosol |
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2921 55660 PRPF40A False True mRNA Splicing - Major Pathway |
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2922 55664 CDC37L1 False True Platelet degranulation |
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2923 55665 URGCP False True NA |
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2924 55666 NPLOC4 False True Translesion Synthesis by POLH |
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2925 55671 SMEK1 False True NA |
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2926 55677 IWS1 False True Formation of RNA Pol II elongation complex ;RNA Polymerase II Pre-transcription Events;RNA Polymerase II Transcription Elongation |
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2927 55679 LIMS2 False True Cell-extracellular matrix interactions |
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2928 55681 SCYL2 False True NA |
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2929 55699 IARS2 False True Mitochondrial tRNA aminoacylation |
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2930 55706 NA False True ISG15 antiviral mechanism;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Rev-mediated nuclear export of HIV RNA;Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Viral Messenger RNA Synthesis;NEP/NS2 Interacts with the Cellular Export Machinery;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;snRNP Assembly;SUMOylation of DNA damage response and repair proteins;SUMOylation of ubiquitinylation proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;SUMOylation of SUMOylation proteins;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins;Transcriptional regulation by small RNAs;tRNA processing in the nucleus |
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2931 55707 NECAP2 False True Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis |
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2932 55709 KBTBD4 False True NA |
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2933 55714 NA False True NA |
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2934 55720 TSR1 False True Major pathway of rRNA processing in the nucleolus and cytosol |
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2935 55722 CEP72 False True Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;AURKA Activation by TPX2 |
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2936 55737 VPS35 False True WNT ligand biogenesis and trafficking |
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2937 55739 CARKD False True Nicotinamide salvaging |
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2938 55746 NUP133 False True ISG15 antiviral mechanism;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Rev-mediated nuclear export of HIV RNA;Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Viral Messenger RNA Synthesis;NEP/NS2 Interacts with the Cellular Export Machinery;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;snRNP Assembly;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;SUMOylation of DNA damage response and repair proteins;SUMOylation of ubiquitinylation proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;SUMOylation of SUMOylation proteins;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins;Transcriptional regulation by small RNAs;RHO GTPases Activate Formins;tRNA processing in the nucleus;Mitotic Prometaphase |
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2939 55748 CNDP2 False True Glutathione synthesis and recycling |
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2940 55758 RCOR3 False True NA |
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2941 55778 ZNF839 False True Generic Transcription Pathway |
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2942 55787 TXLNG False True NA |
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2943 55791 LRIF1 False True NA |
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2944 55812 SPATA7 False True NA |
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2945 55814 BDP1 False True RNA Polymerase III Abortive And Retractive Initiation;RNA Polymerase III Transcription Initiation From Type 1 Promoter;RNA Polymerase III Transcription Initiation From Type 1 Promoter;RNA Polymerase III Transcription Initiation From Type 2 Promoter;RNA Polymerase III Transcription Initiation From Type 2 Promoter;RNA Polymerase III Transcription Initiation From Type 3 Promoter;RNA Polymerase III Transcription Initiation From Type 3 Promoter |
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2946 55815 TSNAXIP1 False True NA |
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2947 55835 CENPJ False True Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain;AURKA Activation by TPX2 |
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2948 55845 BRK1 False True Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;VEGFA-VEGFR2 Pathway;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs |
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2949 55846 ITFG2 False True NA |
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2950 55848 PLGRKT False True NA |
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2951 55850 USE1 False True COPI-dependent Golgi-to-ER retrograde traffic |
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2952 55861 DBNDD2 False True NA |
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2953 55884 WSB2 False True Neddylation |
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2954 55898 UNC45A False True NA |
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2955 55905 RNF114 False True Antigen processing: Ubiquitination & Proteasome degradation |
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2956 55916 NXT2 False True NA |
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2957 55929 DMAP1 False True HATs acetylate histones |
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2958 55930 MYO5C False True NA |
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2959 55968 NSFL1C False True NA |
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2960 55970 GNG12 False True Activation of G protein gated Potassium channels;Glucagon signaling in metabolic regulation;G-protein activation;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;ADP signalling through P2Y purinoceptor 12;G beta:gamma signalling through PI3Kgamma;Prostacyclin signalling through prostacyclin receptor;Prostacyclin signalling through prostacyclin receptor;Adrenaline,noradrenaline inhibits insulin secretion;Adrenaline,noradrenaline inhibits insulin secretion;Ca2+ pathway;Ca2+ pathway;G alpha (q) signalling events;G alpha (12/13) signalling events;G beta:gamma signalling through PLC beta;G alpha (s) signalling events;ADP signalling through P2Y purinoceptor 1;ADP signalling through P2Y purinoceptor 1;G alpha (i) signalling events;G alpha (z) signalling events;Glucagon-type ligand receptors;Thromboxane signalling through TP receptor;Vasopressin regulates renal water homeostasis via Aquaporins;Thrombin signalling through proteinase activated receptors (PARs);Thrombin signalling through proteinase activated receptors (PARs);Presynaptic function of Kainate receptors;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding;G beta:gamma signalling through BTK;G beta:gamma signalling through CDC42;Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
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2961 55975 KLHL7 False True NA |
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2962 56061 UBFD1 False True NA |
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2963 56063 TMEM234 False True NA |
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2964 56243 KIAA1217 False True NA |
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2965 56259 CTNNBL1 False True mRNA Splicing - Major Pathway |
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2966 56288 PARD3 False True TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);Tight junction interactions |
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2967 56300 NA True False Interleukin-36 pathway |
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2968 56311 NA False True NA |
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2969 56338 Txnip False True NA |
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2970 56339 METTL3 False True Processing of Capped Intron-Containing Pre-mRNA |
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2971 56424 Stub1 False True NA |
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2972 56475 RPRM False True NA |
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2973 56477 CCL28 False True Chemokine receptors bind chemokines;G alpha (i) signalling events |
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2974 56647 BCCIP False True NA |
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2975 56648 EIF5A2 False True Hypusine synthesis from eIF5A-lysine |
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2976 56649 TMPRSS4 False True NA |
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2977 56650 CLDND1 False True NA |
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2978 56658 TRIM39 False True Antigen processing: Ubiquitination & Proteasome degradation |
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2979 56659 NA False True Tandem pore domain halothane-inhibited K+ channel (THIK);Phase 4 - resting membrane potential |
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2980 56667 NA False True Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC);Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS);Defective GALNT12 causes colorectal cancer 1 (CRCS1);Dectin-2 family;O-linked glycosylation of mucins;Termination of O-glycan biosynthesis |
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2981 56850 GRIPAP1 False True NA |
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2982 56882 CDC42SE1 False True NA |
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2983 56888 KCMF1 False True Neutrophil degranulation |
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2984 56893 UBQLN4 False True NA |
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2985 56896 DPYSL5 False True CRMPs in Sema3A signaling |
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2986 56902 PNO1 False True rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol |
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2987 56904 SH3GLB2 False True NA |
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2988 56907 NA False True NA |
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2989 56915 EXOSC5 False True ATF4 activates genes;mRNA decay by 3' to 5' exoribonuclease;Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA;Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA;KSRP (KHSRP) binds and destabilizes mRNA;Major pathway of rRNA processing in the nucleolus and cytosol |
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2990 56924 PAK6 False True Activation of RAC1 |
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2991 56925 LXN False True NA |
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2992 56927 NA False True NA |
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2993 56931 DUS3L False True NA |
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2994 56935 SMCO4 False True NA |
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2995 56954 NIT2 False True Neutrophil degranulation |
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2996 56984 PSMG2 False True NA |
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2997 56987 BBX False True NA |
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2998 56998 CTNNBIP1 False True Deactivation of the beta-catenin transactivating complex |
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2999 57003 CCDC47 False True NA |
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3000 57016 AKR1B10 False True Retinoid metabolism and transport |
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3001 57062 DDX24 False True NA |
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3002 57082 CASC5 False True Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Deposition of new CENPA-containing nucleosomes at the centromere;Mitotic Prometaphase |
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3003 57085 AGTRAP False True Signaling by BRAF and RAF fusions |
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3004 57092 PCNP False True NA |
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3005 57093 TRIM49 False True NA |
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3006 57107 PDSS2 False True Ubiquinol biosynthesis |
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parents:
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3007 57142 RTN4 False True Axonal growth inhibition (RHOA activation) |
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3008 57157 NA False True NA |
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3009 57159 TRIM54 False True NA |
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3010 57165 NA False True Gap junction assembly |
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3011 57168 NA False True NA |
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3012 57169 ZNFX1 False True NA |
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3013 57172 CAMK1G False True NA |
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3014 57175 CORO1B False True NA |
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3015 57185 NIPAL3 False True Miscellaneous transport and binding events |
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3016 57228 NA False True NA |
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3017 57402 S100A14 True True NA |
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3018 57418 WDR18 False True Major pathway of rRNA processing in the nucleolus and cytosol |
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3019 57462 KIAA1161 False True NA |
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3020 57472 CNOT6 False True Deadenylation of mRNA;Activation of anterior HOX genes in hindbrain development during early embryogenesis;TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain |
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3021 57474 ZNF490 False True Generic Transcription Pathway |
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3022 57479 PRR12 False True NA |
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3023 57506 MAVS False True DDX58/IFIH1-mediated induction of interferon-alpha/beta;Ovarian tumor domain proteases;TRAF3-dependent IRF activation pathway;TRAF6 mediated IRF7 activation;TRAF6 mediated NF-kB activation;TRAF6 mediated NF-kB activation;NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10;Negative regulators of DDX58/IFIH1 signaling;Negative regulators of DDX58/IFIH1 signaling |
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3024 57507 NA False True NA |
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3025 57510 XPO5 False True MicroRNA (miRNA) biogenesis |
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3026 57521 RPTOR False True Macroautophagy;mTOR signalling;mTORC1-mediated signalling;HSF1-dependent transactivation;Energy dependent regulation of mTOR by LKB1-AMPK;TP53 Regulates Metabolic Genes;Regulation of PTEN gene transcription |
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3027 57528 NA False True NA |
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3028 57530 CGN False True TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
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3029 57542 KLHL42 False True Neddylation;Antigen processing: Ubiquitination & Proteasome degradation |
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3030 57544 TXNDC16 False True NA |
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3031 57552 NCEH1 False True LDL clearance |
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3032 57553 NA False True NA |
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3033 57562 NA False True NA |
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3034 57563 KLHL8 False True NA |
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3035 57565 KLHL14 False True NA |
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3036 57584 NA False True Rho GTPase cycle |
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3037 57599 WDR48 False True Recognition of DNA damage by PCNA-containing replication complex;Ub-specific processing proteases;Fanconi Anemia Pathway |
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3038 57600 FNIP2 False True NA |
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3039 57617 VPS18 False True NA |
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3040 57619 NA False True NA |
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3041 57623 NA False True NA |
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3042 57626 KLHL1 False True NA |
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3043 57645 POGK False True NA |
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3044 57658 CALCOCO1 False True NA |
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3045 57670 KIAA1549 False True Signaling by BRAF and RAF fusions |
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3046 57680 CHD8 False True Deactivation of the beta-catenin transactivating complex |
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3047 57707 TLDC1 False True NA |
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3048 57718 PPP4R4 False True NA |
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3049 57722 NA False True NA |
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3050 57794 SUGP1 False True mRNA Splicing - Major Pathway |
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3051 57798 GATAD1 False True NA |
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3052 57805 CCAR2 False True Regulation of HSF1-mediated heat shock response |
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3053 57819 LSM2 False True mRNA decay by 5' to 3' exoribonuclease;mRNA decay by 5' to 3' exoribonuclease;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway |
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3054 57820 CCNB1IP1 False True NA |
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parents:
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3055 58191 CXCL16 False True Chemokine receptors bind chemokines;G alpha (i) signalling events |
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parents:
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3056 58477 SRPRB False True SRP-dependent cotranslational protein targeting to membrane;XBP1(S) activates chaperone genes |
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3057 58484 NLRC4 False True TP53 Regulates Transcription of Caspase Activators and Caspases;The IPAF inflammasome;The IPAF inflammasome |
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3058 58490 RPRD1B False True RNA polymerase II transcribes snRNA genes;RNA polymerase II transcribes snRNA genes |
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3059 58506 NA False True NA |
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3060 58515 SELK False True NA |
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3061 58517 RBM25 False True NA |
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3062 58524 DMRT3 False True NA |
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3063 58529 MYOZ1 False True NA |
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parents:
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3064 59277 NA False True Non-integrin membrane-ECM interactions;Netrin-1 signaling |
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3065 59286 UBL5 False True NA |
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3066 59343 SENP2 False True SUMO is proteolytically processed |
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3067 60312 AFAP1 False True NA |
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3068 60314 C12orf10 False True NA |
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3069 60485 SAV1 False True Signaling by Hippo |
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3070 60491 NIF3L1 False True NA |
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3071 60492 CCDC90B False True NA |
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3072 60496 AASDHPPT False True Vitamin B5 (pantothenate) metabolism |
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3073 60528 ELAC2 False True tRNA processing in the nucleus;tRNA processing in the mitochondrion;rRNA processing in the mitochondrion |
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3074 60558 NA False True NA |
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3075 60684 TRAPPC11 False True RAB GEFs exchange GTP for GDP on RABs |
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3076 63027 SLC22A23 False True NA |
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3077 63892 THADA False True tRNA modification in the nucleus and cytosol |
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3078 63893 UBE2O False True Antigen processing: Ubiquitination & Proteasome degradation |
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3079 63925 ZNF335 False True Activation of anterior HOX genes in hindbrain development during early embryogenesis |
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3080 63932 CXorf56 False True NA |
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3081 63943 FKBPL False True The role of GTSE1 in G2/M progression after G2 checkpoint |
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3082 63951 DMRTA1 False True NA |
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3083 63982 NA False True Stimuli-sensing channels |
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3084 64062 RBM26 False True NA |
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3085 64065 NA True False TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain;Formation of the cornified envelope |
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3086 64087 MCCC2 False True Biotin transport and metabolism;Defective HLCS causes multiple carboxylase deficiency;Branched-chain amino acid catabolism |
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3087 64092 SAMSN1 False True NA |
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3088 64102 TNMD False True NA |
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3089 64105 CENPK False True Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Deposition of new CENPA-containing nucleosomes at the centromere;Mitotic Prometaphase |
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3090 64129 TINAGL1 False True NA |
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3091 64184 EDDM3B False True NA |
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3092 64215 DNAJC1 False True NA |
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3093 64320 RNF25 False True Antigen processing: Ubiquitination & Proteasome degradation |
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3094 64326 RFWD2 False True Autodegradation of the E3 ubiquitin ligase COP1;Neddylation |
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3095 64327 NA False True NA |
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3096 64344 HIF3A False True Regulation of gene expression by Hypoxia-inducible Factor;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Transcriptional regulation of pluripotent stem cells;Neddylation |
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3097 64374 SIL1 False True NA |
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3098 64407 RGS18 False True G alpha (q) signalling events;G alpha (i) signalling events;G alpha (i) signalling events |
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3099 64410 NA False True Neddylation;Antigen processing: Ubiquitination & Proteasome degradation |
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3100 64412 GZF1 False True NA |
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3101 64417 C5orf28 False True NA |
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3102 64423 NA False True NA |
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3103 64428 NARFL False True Cytosolic iron-sulfur cluster assembly |
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3104 64648 NA False True NA |
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3105 64663 NA False True NA |
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parents:
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3106 64708 COPS7B False True DNA Damage Recognition in GG-NER;Formation of TC-NER Pre-Incision Complex;Cargo recognition for clathrin-mediated endocytosis;Neddylation |
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3107 64714 PDIA2 False True NA |
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3108 64745 METTL17 False True NA |
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3109 64750 SMURF2 False True Signaling by BMP;Downregulation of TGF-beta receptor signaling;Downregulation of TGF-beta receptor signaling;Downregulation of SMAD2/3:SMAD4 transcriptional activity;Downregulation of SMAD2/3:SMAD4 transcriptional activity;Asymmetric localization of PCP proteins;Degradation of AXIN;Hedgehog 'on' state;Hedgehog 'on' state;Ub-specific processing proteases;Regulation of RUNX3 expression and activity;Antigen processing: Ubiquitination & Proteasome degradation |
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3110 64754 SMYD3 False True PKMTs methylate histone lysines |
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3111 64755 C16orf58 False True NA |
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3112 64759 TNS3 False True MET interacts with TNS proteins |
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3113 64763 ZNF574 False True NA |
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3114 64771 C6orf106 False True NA |
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3115 64784 CRTC3 False True Transcriptional activation of mitochondrial biogenesis;Circadian Clock |
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3116 64785 GINS3 False True Unwinding of DNA;Unwinding of DNA |
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3117 64837 KLC2 False True MHC class II antigen presentation;RHO GTPases activate KTN1;COPI-dependent Golgi-to-ER retrograde traffic;Kinesins |
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3118 64848 NA False True NA |
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3119 64849 NA False True Sodium-coupled sulphate, di- and tri-carboxylate transporters |
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3120 64866 CDCP1 False True NA |
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3121 64926 NA False True Regulation of RAS by GAPs;Signaling by RAS mutants |
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3122 64965 MRPS9 False True Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation elongation;Mitochondrial translation termination |
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3123 64969 MRPS5 False True Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation elongation;Mitochondrial translation termination |
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3124 64976 MRPL40 False True Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation elongation;Mitochondrial translation termination |
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3125 64979 MRPL36 False True Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation elongation;Mitochondrial translation termination |
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3126 65018 PINK1 False True Pink/Parkin Mediated Mitophagy;FOXO-mediated transcription of cell death genes |
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3127 65055 REEP1 False True Olfactory Signaling Pathway |
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3128 65061 CDK15 False True NA |
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3129 65095 KRI1 False True NA |
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3130 65108 MARCKSL1 False True NA |
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3131 65125 WNK1 False True Stimuli-sensing channels |
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3132 65220 NADK False True Nicotinate metabolism |
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3133 65263 PYCRL False True Amino acid synthesis and interconversion (transamination) |
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3134 65265 C8orf33 False True NA |
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3135 65266 WNK4 False True Stimuli-sensing channels |
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3136 65268 WNK2 False True Stimuli-sensing channels |
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3137 65977 NA False True Synthesis of PIPs at the plasma membrane |
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3138 65982 ZSCAN18 False True NA |
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3139 71766 NA False True NA |
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3140 79001 VKORC1 False True Metabolism of vitamin K |
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3141 79003 MIS12 False True Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase |
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3142 79012 CAMKV False True NA |
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3143 79017 GGCT True True Glutathione synthesis and recycling |
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3144 79026 AHNAK False True NA |
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3145 79031 PDCL3 False True NA |
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3146 79039 DDX54 False True NA |
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3147 79047 KCTD15 False True Negative regulation of activity of TFAP2 (AP-2) family transcription factors |
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3148 79050 NOC4L False True rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol |
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3149 79053 ALG8 False True Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein;Defective ALG8 causes ALG8-CDG (CDG-1h) |
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3150 79058 ASPSCR1 False True Translocation of SLC2A4 (GLUT4) to the plasma membrane |
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3151 79073 TMEM109 False True NA |
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3152 79109 MAPKAP1 False True PIP3 activates AKT signaling;CD28 dependent PI3K/Akt signaling;VEGFR2 mediated vascular permeability;Constitutive Signaling by AKT1 E17K in Cancer;Regulation of TP53 Degradation |
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3153 79139 DERL1 False True ABC-family proteins mediated transport;N-glycan trimming in the ER and Calnexin/Calreticulin cycle;Defective CFTR causes cystic fibrosis;E3 ubiquitin ligases ubiquitinate target proteins |
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3154 79152 NA False True Sphingolipid de novo biosynthesis |
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3155 79161 NA False True NA |
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3156 79171 RBM42 False True NA |
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3157 79173 C19orf57 False True NA |
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3158 79176 FBXL15 False True Neddylation;Antigen processing: Ubiquitination & Proteasome degradation |
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3159 79177 ZNF576 False True NA |
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3160 79180 EFHD2 False True NA |
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3161 79183 NA False True NA |
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3162 79188 TMEM43 False True NA |
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3163 79228 THOC6 False True Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA 3'-end processing |
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3164 79366 NA False True NA |
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3165 79415 C17orf62 False True NA |
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3166 79587 CARS2 False True Mitochondrial tRNA aminoacylation |
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3167 79598 CEP97 False True Anchoring of the basal body to the plasma membrane |
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3168 79622 SNRNP25 False True mRNA Splicing - Minor Pathway |
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3169 79624 C6orf211 False True NA |
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3170 79633 NA False True NA |
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3171 79647 NA False True NA |
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3172 79654 HECTD3 False True Antigen processing: Ubiquitination & Proteasome degradation |
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3173 79657 RPAP3 False True NA |
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3174 79666 PLEKHF2 False True NA |
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3175 79669 C3orf52 False True NA |
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3176 79691 QTRTD1 False True tRNA modification in the nucleus and cytosol |
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3177 79696 ZC2HC1C False True NA |
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3178 79710 MORC4 False True NA |
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3179 79711 IPO4 False True NA |
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3180 79717 PPCS False True Coenzyme A biosynthesis |
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3181 79718 TBL1XR1 False True RORA activates gene expression;BMAL1:CLOCK,NPAS2 activates circadian gene expression;PPARA activates gene expression;PPARA activates gene expression;NOTCH1 Intracellular Domain Regulates Transcription;Transcriptional activation of mitochondrial biogenesis;Activation of gene expression by SREBF (SREBP);Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;HDACs deacetylate histones;Transcriptional regulation of white adipocyte differentiation;Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha);Circadian Clock;Loss of MECP2 binding ability to the NCoR/SMRT complex;Regulation of MECP2 expression and activity |
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3182 79724 NA False True NA |
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3183 79726 WDR59 False True NA |
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3184 79728 PALB2 False True HDR through Homologous Recombination (HRR);Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA);Resolution of D-loop Structures through Holliday Junction Intermediates;Homologous DNA Pairing and Strand Exchange |
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3185 79763 ISOC2 False True NA |
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3186 79770 TXNDC15 False True NA |
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3187 79786 KLHL36 False True NA |
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3188 79798 NA False True NA |
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3189 79801 SHCBP1 False True NA |
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3190 79809 NA False True Hedgehog 'off' state;Intraflagellar transport |
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3191 79811 SLTM False True NA |
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3192 79822 NA False True NA |
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3193 79830 NA False True NA |
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3194 79831 KDM8 False True HDMs demethylate histones |
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3195 79839 CCDC102B False True NA |
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3196 79853 TM4SF20 False True NA |
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3197 79858 NEK11 False True NA |
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3198 79861 TUBAL3 False True Translocation of SLC2A4 (GLUT4) to the plasma membrane;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;Gap junction assembly;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HSP90 chaperone cycle for steroid hormone receptors (SHR);Recruitment of NuMA to mitotic centrosomes;Formation of tubulin folding intermediates by CCT/TriC;Post-chaperonin tubulin folding pathway;Recycling pathway of L1;Recycling pathway of L1;Cilium Assembly;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;Carboxyterminal post-translational modifications of tubulin;Carboxyterminal post-translational modifications of tubulin;Activation of AMPK downstream of NMDARs;Kinesins |
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3199 79869 CPSF7 False True Cleavage of Growing Transcript in the Termination Region ;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Processing of Intronless Pre-mRNAs |
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3200 79873 NUDT18 False True Phosphate bond hydrolysis by NUDT proteins |
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3201 79887 PLBD1 True True Acyl chain remodelling of PC;Acyl chain remodelling of PE;Acyl chain remodelling of PI;Hydrolysis of LPC |
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3202 79901 CYBRD1 False True Iron uptake and transport |
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3203 79930 DOK3 False True Neutrophil degranulation |
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3204 79932 NA False True NA |
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3205 79947 DHDDS False True Synthesis of Dolichyl-phosphate;Defective DHDDS causes retinitis pigmentosa 59 |
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3206 79968 WDR76 False True NA |
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3207 79980 DSN1 False True Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Neutrophil degranulation;Mitotic Prometaphase |
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3208 79983 POF1B True True NA |
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3209 80007 C10orf88 False True NA |
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3210 80011 FAM192A False True NA |
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3211 80012 PHC3 False True Oxidative Stress Induced Senescence;SUMOylation of DNA damage response and repair proteins;SUMOylation of transcription cofactors;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA methylation proteins;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known;Regulation of PTEN gene transcription;Regulation of PTEN gene transcription;Transcriptional Regulation by E2F6 |
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3212 80017 C14orf159 False True NA |
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3213 80028 FBXL18 False True NA |
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3214 80086 TUBA4B False True NA |
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3215 80139 NA False True Generic Transcription Pathway |
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3216 80145 THOC7 False True Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA 3'-end processing |
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3217 80153 EDC3 False True mRNA decay by 5' to 3' exoribonuclease |
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3218 80154 GOLGA2P10 False True NA |
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3219 80176 SPSB1 False True Neddylation;Antigen processing: Ubiquitination & Proteasome degradation |
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3220 80179 MYO19 False True NA |
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3221 80185 TTI2 False True NA |
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3222 80196 RNF34 False True Regulation of TP53 Degradation;Antigen processing: Ubiquitination & Proteasome degradation |
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3223 80207 OPA3 False True NA |
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3224 80216 ALPK1 False True NA |
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3225 80217 NA False True NA |
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3226 80218 NAA50 False True NA |
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3227 80223 RAB11FIP1 False True NA |
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3228 80273 GRPEL1 False True Mitochondrial protein import |
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3229 80279 CDK5RAP3 False True NA |
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3230 80301 PLEKHO2 False True Neutrophil degranulation |
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3231 80311 KLHL15 False True NA |
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3232 80314 EPC1 False True HATs acetylate histones;Transcriptional Regulation by E2F6 |
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3233 80318 GKAP1 False True NA |
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3234 80332 ADAM33 False True NA |
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3235 80349 WDR61 False True Formation of RNA Pol II elongation complex ;mRNA decay by 3' to 5' exoribonuclease;RNA Polymerase II Pre-transcription Events;RNA Polymerase II Transcription Elongation;E3 ubiquitin ligases ubiquitinate target proteins |
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3236 80705 TSGA10 False True NA |
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3237 80726 KIAA1683 False True NA |
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3238 80742 PRR3 False True NA |
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3239 80775 TMEM177 False True NA |
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3240 80777 CYB5B False True Phase I - Functionalization of compounds |
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3241 80817 CEP44 False True NA |
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3242 80856 KIAA1715 False True NA |
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3243 81027 TUBB1 False True Translocation of SLC2A4 (GLUT4) to the plasma membrane;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;Gap junction assembly;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HSP90 chaperone cycle for steroid hormone receptors (SHR);Recruitment of NuMA to mitotic centrosomes;Prefoldin mediated transfer of substrate to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Post-chaperonin tubulin folding pathway;Recycling pathway of L1;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;Carboxyterminal post-translational modifications of tubulin;Carboxyterminal post-translational modifications of tubulin;Activation of AMPK downstream of NMDARs;Kinesins |
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3244 81494 CFHR5 False True Regulation of Complement cascade |
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3245 81544 GDPD5 False True Glycerophospholipid catabolism |
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3246 81545 FBXO38 False True NA |
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3247 81556 VWA9 False True RNA polymerase II transcribes snRNA genes;RNA polymerase II transcribes snRNA genes |
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3248 81565 NDEL1 False True Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase |
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3249 81567 TXNDC5 False True Lysosome Vesicle Biogenesis;Golgi Associated Vesicle Biogenesis;Neutrophil degranulation |
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3250 81572 PDRG1 False True NA |
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3251 81576 CCDC130 False True NA |
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3252 81605 URM1 False True tRNA modification in the nucleus and cytosol |
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3253 81611 ANP32E False True NA |
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3254 81624 DIAPH3 False True RHO GTPases Activate Formins |
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3255 81629 TSSK3 False True NA |
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3256 81671 NA False True NA |
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3257 81786 TRIM7 False True NA |
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3258 81788 NUAK2 False True NA |
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3259 81790 RNF170 False True NA |
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3260 81810 NA False True NA |
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3261 81844 TRIM56 False True Regulation of innate immune responses to cytosolic DNA |
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3262 81853 TMEM14B False True NA |
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3263 81873 ARPC5L False True NA |
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3264 81875 NA False True Major pathway of rRNA processing in the nucleolus and cytosol |
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3265 81889 FAHD1 False True Citric acid cycle (TCA cycle) |
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3266 81929 SEH1L False True ISG15 antiviral mechanism;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Rev-mediated nuclear export of HIV RNA;Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Viral Messenger RNA Synthesis;NEP/NS2 Interacts with the Cellular Export Machinery;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;snRNP Assembly;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;SUMOylation of DNA damage response and repair proteins;SUMOylation of ubiquitinylation proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;SUMOylation of SUMOylation proteins;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins;Transcriptional regulation by small RNAs;RHO GTPases Activate Formins;tRNA processing in the nucleus;Mitotic Prometaphase |
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3267 83446 CCDC70 False True NA |
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3268 83481 EPPK1 True True NA |
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3269 83540 NUF2 False True Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase |
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3270 83541 FAM110A False True NA |
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3271 83594 NUDT12 False True Nicotinamide salvaging |
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3272 83640 FAM103A1 False True NA |
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3273 83659 NA False True NA |
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3274 83660 TLN2 False True NA |
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3275 83692 CD99L2 False True Cell surface interactions at the vascular wall |
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3276 83693 NA False True NA |
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3277 83694 NA False True NA |
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3278 83699 SH3BGRL2 False True NA |
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3279 83719 YPEL3 False True NA |
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3280 83737 ITCH False True Downregulation of ERBB4 signaling;NOD1/2 Signaling Pathway;Activated NOTCH1 Transmits Signal to the Nucleus;Activated NOTCH1 Transmits Signal to the Nucleus;Degradation of GLI1 by the proteasome;Hedgehog 'on' state;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Negative regulators of DDX58/IFIH1 signaling;Antigen processing: Ubiquitination & Proteasome degradation |
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3281 83742 NA False True NA |
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3282 83861 RSPH3 False True NA |
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3283 83871 RAB34 False True RAB geranylgeranylation |
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3284 83878 USHBP1 False True NA |
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3285 83939 EIF2A False True NA |
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3286 83942 TSSK1B False True NA |
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3287 83983 TSSK6 False True NA |
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3288 83990 BRIP1 False True Cytosolic iron-sulfur cluster assembly;HDR through Single Strand Annealing (SSA);HDR through Homologous Recombination (HRR);Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA);Resolution of D-loop Structures through Holliday Junction Intermediates;Homologous DNA Pairing and Strand Exchange;Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;Regulation of TP53 Activity through Phosphorylation;G2/M DNA damage checkpoint |
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3289 84059 NA False True NA |
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3290 84060 RBM48 False True NA |
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3291 84063 KIRREL2 False True Nephrin family interactions |
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3292 84065 NA False True NA |
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3293 84074 NA False True NA |
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3294 84076 TKTL2 False True NA |
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3295 84078 KBTBD7 False True Regulation of RAS by GAPs;Neddylation;Antigen processing: Ubiquitination & Proteasome degradation |
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3296 84080 ENKD1 False True NA |
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3297 84102 SLC41A2 False True Metal ion SLC transporters |
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3298 84108 PCGF6 False True Transcriptional Regulation by E2F6 |
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3299 84128 NA False True rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol |
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3300 84131 CEP78 False True Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;AURKA Activation by TPX2 |
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3301 84133 ZNRF3 False True Regulation of FZD by ubiquitination |
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3302 84134 TOMM40L False True NA |
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3303 84140 FAM161A False True NA |
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3304 84148 KAT8 False True HATs acetylate histones |
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3305 84154 RPF2 False True NA |
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3306 84163 NA False True NA |
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3307 84164 ASCC2 False True ALKBH3 mediated reversal of alkylation damage |
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3308 84168 ANTXR1 False True Uptake and function of anthrax toxins |
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3309 84174 SLA2 False True NA |
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3310 84218 NA False True NA |
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3311 84219 WDR24 False True NA |
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3312 84254 CAMKK1 False True CaMK IV-mediated phosphorylation of CREB;CaMK IV-mediated phosphorylation of CREB;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;Activation of RAC1 downstream of NMDARs;Activation of RAC1 downstream of NMDARs |
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3313 84259 DCUN1D5 False True Neddylation |
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3314 84260 TCHP False True NA |
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3315 84262 PSMG3 False True NA |
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3316 84273 NA False True NA |
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3317 84277 DNAJC30 False True NA |
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3318 84290 CAPNS2 False True Degradation of the extracellular matrix;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models |
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3319 84292 WDR83 False True MAP2K and MAPK activation |
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3320 84294 UTP23 False True NA |
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3321 84300 UQCC2 False True NA |
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3322 84301 DDI2 False True NA |
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3323 84314 TMEM107 False True NA |
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3324 84320 ACBD6 False True Mitochondrial Fatty Acid Beta-Oxidation |
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3325 84324 SARNP False True Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA 3'-end processing |
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3326 84333 PCGF5 False True RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known |
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3327 84445 LZTS2 False True NA |
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3328 84447 SYVN1 False True XBP1(S) activates chaperone genes;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;ER Quality Control Compartment (ERQC) |
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3329 84457 PHYHIPL False True NA |
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3330 84501 NA False True NA |
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3331 84522 JAGN1 False True NA |
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3332 84525 HOPX False True NA |
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3333 84614 NA False True NA |
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3334 84617 TUBB6 False True Translocation of SLC2A4 (GLUT4) to the plasma membrane;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;Gap junction assembly;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HSP90 chaperone cycle for steroid hormone receptors (SHR);Recruitment of NuMA to mitotic centrosomes;Prefoldin mediated transfer of substrate to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Post-chaperonin tubulin folding pathway;Recycling pathway of L1;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;Carboxyterminal post-translational modifications of tubulin;Carboxyterminal post-translational modifications of tubulin;Activation of AMPK downstream of NMDARs;Kinesins |
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3335 84619 ZGPAT False True NA |
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3336 84687 PPP1R9B False True NA |
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3337 84707 BEX2 False True NA |
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3338 84708 LNX1 False True Antigen processing: Ubiquitination & Proteasome degradation |
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3339 84717 HDGFRP2 False True NA |
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3340 84759 PCGF1 False True NA |
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3341 84790 TUBA1C False True Translocation of SLC2A4 (GLUT4) to the plasma membrane;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;Gap junction assembly;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HSP90 chaperone cycle for steroid hormone receptors (SHR);Recruitment of NuMA to mitotic centrosomes;Prefoldin mediated transfer of substrate to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Post-chaperonin tubulin folding pathway;Recycling pathway of L1;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;Carboxyterminal post-translational modifications of tubulin;Carboxyterminal post-translational modifications of tubulin;Activation of AMPK downstream of NMDARs;Kinesins |
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3342 84808 NA False True Transcriptional activation of mitochondrial biogenesis |
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3343 84823 LMNB2 False True NA |
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3344 84832 ANKRD36BP1 False True NA |
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3345 84833 NA False True NA |
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3346 84861 KLHL22 False True Neddylation;Antigen processing: Ubiquitination & Proteasome degradation |
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3347 84873 GPR128 False True NA |
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3348 84886 NA False True NA |
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3349 84893 FBXO18 False True NA |
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3350 84902 CEP89 False True Anchoring of the basal body to the plasma membrane |
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3351 84912 SLC35B4 False True Transport of nucleotide sugars |
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3352 84926 NA False True NA |
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3353 84930 MASTL False True MASTL Facilitates Mitotic Progression;MASTL Facilitates Mitotic Progression |
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3354 84936 ZFYVE19 False True NA |
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3355 84939 MUM1 False True NA |
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3356 84946 LTV1 False True Major pathway of rRNA processing in the nucleolus and cytosol |
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3357 84951 TNS4 False True MET interacts with TNS proteins |
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3358 84952 CGNL1 False True NA |
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|
3359 84962 AJUBA False True Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Regulation of PLK1 Activity at G2/M Transition;Activation of anterior HOX genes in hindbrain development during early embryogenesis |
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parents:
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3360 84966 NA False True NA |
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|
3361 84975 MFSD5 False True NA |
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parents:
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3362 84987 COX14 False True TP53 Regulates Metabolic Genes;Respiratory electron transport |
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parents:
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|
3363 84993 UBL7 False True NA |
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parents:
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|
3364 84996 URB1-AS1 False True NA |
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|
3365 85013 TMEM128 False True NA |
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parents:
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3366 85025 NA False True NA |
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parents:
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|
3367 85302 FBF1 False True Anchoring of the basal body to the plasma membrane |
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3368 85359 DGCR6L False True NA |
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3369 85366 MYLK2 False True NA |
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parents:
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3370 85369 STRIP1 False True NA |
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3371 85395 NA False True NA |
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parents:
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3372 85415 RHPN2 False True RHO GTPases Activate Rhotekin and Rhophilins;RHO GTPases Activate Rhotekin and Rhophilins |
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|
3373 85437 ZCRB1 False True mRNA Splicing - Minor Pathway |
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|
3374 85439 STON2 False True Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis |
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3375 85440 DOCK7 False True MET activates RAP1 and RAC1;Factors involved in megakaryocyte development and platelet production |
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3376 85451 UNK False True NA |
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3377 85458 DIXDC1 False True NA |
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3378 85459 CEP295 False True NA |
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3379 85464 SSH2 False True NA |
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3380 85481 PSKH2 False True NA |
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3381 87178 PNPT1 False True NA |
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3382 89122 TRIM4 False True Antigen processing: Ubiquitination & Proteasome degradation |
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3383 89777 NA True False Neutrophil degranulation |
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3384 89857 KLHL6 False True NA |
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3385 89872 NA False True Passive transport by Aquaporins |
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3386 89885 FATE1 False True NA |
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3387 89941 RHOT2 False True Rho GTPase cycle |
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parents:
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3388 89953 KLC4 False True MHC class II antigen presentation;RHO GTPases activate KTN1;COPI-dependent Golgi-to-ER retrograde traffic;Kinesins |
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3389 90060 CCDC120 False True NA |
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|
3390 90161 NA False True HS-GAG biosynthesis |
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parents:
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|
3391 90293 KLHL13 False True Neddylation;Antigen processing: Ubiquitination & Proteasome degradation |
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3392 90379 DCAF15 False True NA |
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3393 90407 TMEM41A False True NA |
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|
3394 90410 IFT20 False True Intraflagellar transport;Intraflagellar transport |
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parents:
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|
3395 90411 MCFD2 False True COPII-mediated vesicle transport;Cargo concentration in the ER;Transport to the Golgi and subsequent modification |
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|
3396 90416 NA False True NA |
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|
3397 90417 KNSTRN False True NA |
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parents:
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3398 90488 NA False True NA |
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3399 90523 MLIP False True NA |
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parents:
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|
3400 90594 ZNF439 False True Generic Transcription Pathway |
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parents:
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3401 90678 LRSAM1 False True Antigen processing: Ubiquitination & Proteasome degradation |
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3402 90799 CEP95 False True NA |
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3403 90861 HN1L False True NA |
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3404 90864 NA False True Neddylation |
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3405 90871 TMEM261 False True NA |
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3406 90933 TRIM41 False True Antigen processing: Ubiquitination & Proteasome degradation |
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3407 90957 DHX57 False True NA |
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3408 91147 TMEM67 False True Anchoring of the basal body to the plasma membrane |
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3409 91272 BOD1 False True NA |
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|
3410 91319 DERL3 False True ABC-family proteins mediated transport;Defective CFTR causes cystic fibrosis |
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3411 91369 ANKRD40 False True NA |
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3412 91464 NA False True NA |
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3413 91607 NA False True NA |
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3414 91612 CHURC1 False True NA |
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3415 91624 NEXN False True NA |
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3416 91647 ATPAF2 False True NA |
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3417 91662 NLRP12 False True NA |
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|
3418 91663 MYADM False True NA |
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3419 91683 SYT12 False True Neurexins and neuroligins |
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|
3420 91694 LONRF1 False True Antigen processing: Ubiquitination & Proteasome degradation |
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|
3421 91748 ELMSAN1 False True NA |
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parents:
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changeset
|
3422 91754 NEK9 False True Activation of NIMA Kinases NEK9, NEK6, NEK7;Nuclear Pore Complex (NPC) Disassembly |
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parents:
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|
3423 91768 NA False True Cyclin E associated events during G1/S transition ;Cyclin A:Cdk2-associated events at S phase entry;Factors involved in megakaryocyte development and platelet production |
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3424 91807 MYLK3 False True NA |
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3425 91833 WDR20 False True Ub-specific processing proteases |
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parents:
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|
3426 91869 RFT1 False True Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein;Defective RFT1 causes RFT1-CDG (CDG-1n) |
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3427 92070 NA False True NA |
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parents:
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3428 92092 ZC3HAV1L False True NA |
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3429 92140 MTDH False True NA |
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3430 92345 NAF1 False True NA |
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3431 92346 C1orf105 False True NA |
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3432 92359 CRB3 False True Tight junction interactions |
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3433 92399 MRRF False True Mitochondrial translation termination |
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3434 92483 LDHAL6B False True Pyruvate metabolism |
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3435 92521 SPECC1 False True NA |
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3436 92558 NA False True NA |
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3437 92597 MOB1B False True Signaling by Hippo |
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3438 92749 NA False True NA |
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3439 92840 REEP6 False True Olfactory Signaling Pathway |
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3440 92906 HNRNPLL False True NA |
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3441 92922 NA False True NA |
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|
3442 92935 MARS2 False True Mitochondrial tRNA aminoacylation |
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3443 92979 MARCH9 False True NA |
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3444 93100 NAPRT False True Nicotinamide salvaging;Neutrophil degranulation |
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3445 93323 HAUS8 False True Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;AURKA Activation by TPX2 |
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3446 93426 SYCE1 False True Meiotic synapsis |
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3447 93986 FOXP2 False True NA |
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3448 94005 PIGS False True Attachment of GPI anchor to uPAR |
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3449 94081 SFXN1 False True NA |
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3450 94101 ORMDL1 False True Sphingolipid de novo biosynthesis |
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3451 94103 ORMDL3 False True Sphingolipid de novo biosynthesis;Neutrophil degranulation |
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3452 94107 NA False True NA |
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3453 96459 FNIP1 False True NA |
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3454 103910 MYL12B False True EPHA-mediated growth cone collapse;Sema4D induced cell migration and growth-cone collapse;Smooth Muscle Contraction;RHO GTPases activate PKNs;RHO GTPases activate CIT;RHO GTPases Activate ROCKs;RHO GTPases activate PAKs;RHO GTPases activate PAKs |
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3455 112399 EGLN3 False True Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha |
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3456 112616 NA False True NA |
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3457 112714 TUBA3E False True Translocation of SLC2A4 (GLUT4) to the plasma membrane;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;Gap junction assembly;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HSP90 chaperone cycle for steroid hormone receptors (SHR);Recruitment of NuMA to mitotic centrosomes;Formation of tubulin folding intermediates by CCT/TriC;Post-chaperonin tubulin folding pathway;Recycling pathway of L1;Recycling pathway of L1;Cilium Assembly;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;Carboxyterminal post-translational modifications of tubulin;Carboxyterminal post-translational modifications of tubulin;Activation of AMPK downstream of NMDARs;Kinesins |
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3458 112770 C1orf85 False True NA |
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3459 112802 KRT71 False True Keratinization;Formation of the cornified envelope |
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3460 112858 TP53RK False True tRNA modification in the nucleus and cytosol;Regulation of TP53 Activity through Phosphorylation |
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3461 112869 CCDC101 False True HATs acetylate histones |
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3462 112936 VPS26B False True NA |
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3463 112950 MED8 False True PPARA activates gene expression;Generic Transcription Pathway;Transcriptional regulation of white adipocyte differentiation;Transcriptional regulation of white adipocyte differentiation |
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3464 113146 AHNAK2 False True NA |
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3465 113220 KIF12 False True COPI-dependent Golgi-to-ER retrograde traffic;Kinesins |
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3466 113452 TMEM54 False True NA |
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3467 113829 NA False True NA |
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3468 113878 DTX2 False True Activated NOTCH1 Transmits Signal to the Nucleus;Activated NOTCH1 Transmits Signal to the Nucleus |
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3469 114792 KLHL32 False True NA |
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3470 114818 KLHL29 False True NA |
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3471 114822 RHPN1 False True RHO GTPases Activate Rhotekin and Rhophilins;RHO GTPases Activate Rhotekin and Rhophilins |
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3472 114824 PNMA5 False True NA |
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3473 114882 NA False True Acyl chain remodelling of PS |
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3474 114883 OSBPL9 False True Synthesis of bile acids and bile salts |
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3475 114897 NA False True NA |
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3476 114907 FBXO32 False True Neddylation;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes;Antigen processing: Ubiquitination & Proteasome degradation |
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3477 114971 PTPMT1 False True Synthesis of PG |
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3478 114984 FLYWCH2 False True NA |
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3479 115106 HAUS1 False True Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;AURKA Activation by TPX2 |
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3480 115207 KCTD12 False True NA |
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3481 115290 FBXO17 False True Neddylation;Antigen processing: Ubiquitination & Proteasome degradation |
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3482 115353 LRRC42 False True NA |
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3483 115548 FCHO2 False True Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis |
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3484 116039 NA False True NA |
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3485 116138 KLHDC3 False True XBP1(S) activates chaperone genes |
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3486 116173 CMTM5 False True NA |
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3487 116540 MRPL53 False True Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation elongation;Mitochondrial translation termination |
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3488 116988 NA False True NA |
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3489 117157 SH2D1B False True Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
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3490 117159 DCD True True Antimicrobial peptides |
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3491 117177 RAB3IP False True Anchoring of the basal body to the plasma membrane;VxPx cargo-targeting to cilium;BBSome-mediated cargo-targeting to cilium;RAB GEFs exchange GTP for GDP on RABs |
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3492 117178 SSX2IP False True NA |
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3493 117284 Lrrc7 False True NA |
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3494 117583 PARD3B False True NA |
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3495 118460 EXOSC6 False True ATF4 activates genes;mRNA decay by 3' to 5' exoribonuclease;Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA;Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA;KSRP (KHSRP) binds and destabilizes mRNA;Major pathway of rRNA processing in the nucleolus and cytosol |
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3496 119016 NA False True NA |
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3497 119358 NA False True NA |
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3498 120892 LRRK2 False True PTK6 promotes HIF1A stabilization |
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3499 121355 GTSF1 False True NA |
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3500 121457 IKBIP False True NA |
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3501 122060 SLAIN1 False True NA |
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3502 122258 NA False True NA |
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3503 123169 LEO1 False True Formation of RNA Pol II elongation complex ;Formation of the beta-catenin:TCF transactivating complex;RNA Polymerase II Pre-transcription Events;RNA Polymerase II Transcription Elongation;E3 ubiquitin ligases ubiquitinate target proteins |
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3504 123811 NA False True NA |
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3505 123920 CMTM3 False True NA |
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3506 124220 ZG16B True True NA |
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3507 124540 MSI2 False True NA |
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3508 124641 OVCA2 False True NA |
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3509 124801 LSM12 False True NA |
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3510 124997 WDR81 False True NA |
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3511 125058 TBC1D16 False True TBC/RABGAPs |
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3512 125115 KRT40 False True Keratinization;Formation of the cornified envelope |
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3513 125488 NA False True NA |
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3514 125875 NA False True NA |
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3515 126003 TRAPPC5 False True COPII-mediated vesicle transport;RAB GEFs exchange GTP for GDP on RABs |
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3516 126070 ZNF440 False True Generic Transcription Pathway |
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3517 126123 NA False True Sperm:Oocyte Membrane Binding |
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3518 126298 NA False True NA |
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3519 126326 NA False True NA |
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3520 126353 MISP False True NA |
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3521 126433 FBXO27 False True Neddylation;Antigen processing: Ubiquitination & Proteasome degradation |
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3522 127247 ASB17 False True Neddylation;Antigen processing: Ubiquitination & Proteasome degradation |
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3523 127544 RNF19B False True Antigen processing: Ubiquitination & Proteasome degradation |
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3524 127703 C1orf216 False True NA |
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3525 128240 APOA1BP False True Nicotinamide salvaging |
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3526 128653 NA False True NA |
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3527 128869 PIGU False True Attachment of GPI anchor to uPAR |
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3528 128989 TANGO2 False True NA |
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3529 129807 NEU4 False True Glycosphingolipid metabolism;Sialic acid metabolism |
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3530 129852 NA False True NA |
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3531 130399 NA False True Signaling by NODAL;Regulation of signaling by NODAL;Signaling by Activin;Signaling by Activin |
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3532 130872 NA False True NA |
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3533 131118 DNAJC19 False True Mitochondrial protein import |
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3534 131616 NA False True NA |
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3535 131831 ERICH6 False True NA |
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3536 131890 NA False True Inactivation, recovery and regulation of the phototransduction cascade |
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3537 132001 TAMM41 False True NA |
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3538 132158 GLYCTK False True Fructose catabolism |
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3539 132789 GNPDA2 False True Glycolysis |
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3540 132864 CPEB2 False True NA |
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3541 133022 NA False True NA |
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3542 133746 NA False True Regulation of TP53 Activity through Methylation |
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3543 134218 DNAJC21 False True NA |
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3544 135228 NA False True Platelet degranulation ;Post-translational modification: synthesis of GPI-anchored proteins |
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3545 136319 MTPN False True NA |
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3546 138716 NA False True NA |
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3547 139324 NA False True NA |
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3548 139741 NA False True NA |
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3549 140459 ASB6 False True Neddylation;Antigen processing: Ubiquitination & Proteasome degradation |
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3550 140465 MYL6B False True Smooth Muscle Contraction |
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3551 140467 NA False True NA |
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3552 140469 NA False True NA |
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3553 140576 S100A16 False True NA |
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3554 140691 TRIM69 False True Antigen processing: Ubiquitination & Proteasome degradation |
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3555 140738 TMEM37 False True NA |
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3556 140739 UBE2F False True Neddylation;Antigen processing: Ubiquitination & Proteasome degradation |
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3557 140801 RPL10L False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
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3558 140807 NA False True Keratinization;Formation of the cornified envelope |
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3559 140823 ROMO1 False True NA |
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3560 140850 DEFB127 False True Beta defensins;Defensins |
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3561 140885 SIRPA False True Cell surface interactions at the vascular wall;Signal regulatory protein family interactions;Signal regulatory protein family interactions;Neutrophil degranulation |
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3562 142684 RAB40A False True RAB geranylgeranylation |
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3563 143244 EIF5AL1 False True NA |
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3564 143471 PSMA8 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Antigen processing: Ubiquitination & Proteasome degradation |
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3565 143630 NA False True NA |
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3566 143884 CWF19L2 False True NA |
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3567 144097 C11orf84 False True NA |
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3568 144110 NA False True NA |
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3569 144404 TMEM120B False True NA |
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3570 144406 NA False True NA |
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3571 144501 NA True False Keratinization;Formation of the cornified envelope |
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3572 144568 NA True False NA |
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3573 144699 FBXL14 False True Neddylation;Antigen processing: Ubiquitination & Proteasome degradation |
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3574 144983 HNRNPA1L2 False True NA |
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3575 145264 SERPINA12 True True NA |
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3576 145946 SPATA8 False True NA |
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3577 147007 TMEM199 False True NA |
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3578 147687 ZNF417 False True Generic Transcription Pathway |
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3579 147700 KLC3 False True MHC class II antigen presentation;RHO GTPases activate KTN1;COPI-dependent Golgi-to-ER retrograde traffic;Kinesins |
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3580 147746 HIPK4 False True NA |
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3581 147872 CCDC155 False True NA |
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3582 148266 NA False True Generic Transcription Pathway |
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3583 148281 SYT6 False True NA |
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3584 148867 NA False True Insulin processing;Zinc efflux and compartmentalization by the SLC30 family |
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3585 149111 NA False True COPII-mediated vesicle transport;Cargo concentration in the ER |
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3586 149371 EXOC8 False True Translocation of SLC2A4 (GLUT4) to the plasma membrane;Insulin processing;VxPx cargo-targeting to cilium |
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3587 149420 PDIK1L False True NA |
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3588 149950 NA False True NA |
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3589 150094 SIK1 False True Circadian Clock |
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3590 150275 CCDC117 False True NA |
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3591 150353 NA False True NA |
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3592 150483 TEKT4 False True NA |
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3593 150684 COMMD1 False True Neddylation |
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3594 151011 SEPT10 False True NA |
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3595 151230 NA False True NA |
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3596 151246 SGOL2 False True Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase |
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3597 151254 ALS2CR11 False True NA |
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3598 151393 RMDN2 False True NA |
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3599 152110 NA False True NA |
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3600 152137 CCDC50 False True NA |
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3601 152756 NA False True NA |
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3602 153769 SH3RF2 False True NA |
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3603 154754 NA False True NA |
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3604 154796 AMOT False True Signaling by Hippo |
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3605 155030 gag False True Uncoating of the HIV Virion;Budding and maturation of HIV virion;Integration of provirus;Early Phase of HIV Life Cycle;Minus-strand DNA synthesis;Plus-strand DNA synthesis;2-LTR circle formation;Binding and entry of HIV virion;Membrane binding and targetting of GAG proteins;Synthesis And Processing Of GAG, GAGPOL Polyproteins;Assembly Of The HIV Virion;Integration of viral DNA into host genomic DNA;Autointegration results in viral DNA circles;APOBEC3G mediated resistance to HIV-1 infection;Vpr-mediated nuclear import of PICs |
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3606 157285 SGK223 False True NA |
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3607 157378 TMEM65 False True NA |
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3608 157680 NA False True NA |
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3609 157753 NA False True NA |
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3610 158787 RIBC1 False True NA |
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3611 158866 NA False True NA |
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3612 159989 CCDC67 False True NA |
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3613 160140 C11orf65 False True NA |
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3614 160287 LDHAL6A False True Pyruvate metabolism |
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3615 160760 PPTC7 False True NA |
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3616 161142 FAM71D False True NA |
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3617 164127 CCDC185 False True NA |
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3618 165721 DNAJB8 False True NA |
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3619 166614 DCLK2 False True NA |
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3620 166793 ZBTB49 False True NA |
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3621 166929 NA False True Sphingolipid de novo biosynthesis |
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3622 167465 NA False True NA |
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3623 167838 TXLNB False True NA |
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3624 168400 DDX53 False True NA |
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3625 169026 SLC30A8 False True Insulin processing;Zinc efflux and compartmentalization by the SLC30 family |
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3626 169714 QSOX2 False True NA |
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3627 170082 TCEANC False True NA |
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3628 170394 NA False True NA |
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3629 170954 PPP1R18 False True NA |
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3630 171024 SYNPO2 False True NA |
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3631 171483 FAM9B False True NA |
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3632 196051 PPAPDC1A False True Role of phospholipids in phagocytosis |
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3633 196374 NA True False Keratinization;Formation of the cornified envelope |
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3634 196549 NA False True NA |
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3635 199953 NA False True NA |
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3636 199990 C1orf86 False True Fanconi Anemia Pathway |
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3637 200081 TXLNA False True Other interleukin signaling |
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3638 200205 IBA57 False True NA |
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3639 201161 CENPV False True NA |
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3640 201163 FLCN False True NA |
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3641 201164 NA False True Synthesis of PG;Synthesis of PA;PIWI-interacting RNA (piRNA) biogenesis |
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3642 201181 ZNF385C False True NA |
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3643 202459 OSTCP1 False True NA |
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3644 202559 KHDRBS2 False True PTK6 Regulates Proteins Involved in RNA Processing |
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3645 203062 TSNARE1 False True NA |
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3646 203068 TUBB False True Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;Neutrophil degranulation;AURKA Activation by TPX2 |
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3647 206338 NA False True NA |
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3648 219749 NA False True Generic Transcription Pathway |
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3649 219854 TMEM218 False True NA |
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3650 219988 PATL1 False True mRNA decay by 5' to 3' exoribonuclease;mRNA decay by 5' to 3' exoribonuclease |
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3651 220717 RPLP0P6 False True NA |
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3652 220988 HNRNPA3 False True mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA |
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3653 221092 HNRNPUL2 False True NA |
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3654 221443 OARD1 False True NA |
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3655 221927 BRAT1 False True NA |
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3656 221938 NA False True NA |
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3657 222229 LRWD1 False True NA |
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3658 222235 FBXL13 False True Neddylation;Antigen processing: Ubiquitination & Proteasome degradation |
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3659 222484 LNX2 False True NA |
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3660 222662 LHFPL5 False True NA |
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3661 225689 MAPK15 False True NA |
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3662 253143 NA False True NA |
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3663 253827 MSRB3 False True Protein repair |
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3664 253943 YTHDF3 False True NA |
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3665 254359 NA False True NA |
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3666 254428 NA False True Metal ion SLC transporters |
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3667 254879 NA False True Olfactory Signaling Pathway |
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3668 255189 NA False True Acyl chain remodelling of PC;Acyl chain remodelling of PS;Acyl chain remodelling of PE;Acyl chain remodelling of PI;Acyl chain remodelling of PG;Hydrolysis of LPC |
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3669 255394 TCP11L2 False True NA |
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3670 257000 TINCR False True NA |
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3671 257240 KLHL34 False True NA |
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3672 259217 NA False True Regulation of HSF1-mediated heat shock response |
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3673 259232 NALCN False True Stimuli-sensing channels |
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3674 261726 TIPRL False True NA |
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3675 282974 STK32C False True NA |
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3676 283078 MKX False True NA |
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3677 283160 NA False True Olfactory Signaling Pathway |
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3678 283165 NA False True NA |
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3679 283209 PGM2L1 False True Glycogen synthesis;Glycolysis;Glycogen breakdown (glycogenolysis);Galactose catabolism |
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3680 283237 TTC9C False True NA |
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3681 283385 MORN3 False True NA |
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3682 283431 NA False True NA |
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3683 283455 KSR2 False True MAP2K and MAPK activation;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF |
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3684 283458 NA False True NA |
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3685 283742 FAM98B False True tRNA processing in the nucleus |
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3686 283870 NA False True NA |
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3687 284058 KANSL1 False True HATs acetylate histones |
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3688 284069 NA False True NA |
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3689 284076 TTLL6 False True Carboxyterminal post-translational modifications of tubulin |
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3690 284086 NEK8 False True NA |
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3691 284217 LAMA1 False True Laminin interactions;Laminin interactions;Non-integrin membrane-ECM interactions;ECM proteoglycans;L1CAM interactions;MET activates PTK2 signaling |
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3692 284276 NA False True NA |
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3693 284403 WDR62 False True NA |
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3694 284415 NA False True NA |
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3695 284418 FAM71E2 False True NA |
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3696 284618 NA False True NA |
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3697 285093 NA False True Olfactory Signaling Pathway |
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3698 285753 CEP57L1 False True NA |
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3699 286077 FAM83H False True NA |
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3700 286262 TPRN False True NA |
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3701 286410 ATP11C False True Ion transport by P-type ATPases |
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3702 286451 NA False True Golgi Associated Vesicle Biogenesis |
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3703 286887 NA False True Keratinization;Formation of the cornified envelope |
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3704 287015 TRIM42 False True NA |
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3705 317649 EIF4E3 False True ISG15 antiviral mechanism |
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3706 317719 KLHL10 False True NA |
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3707 317772 HIST2H2AB False True HDACs deacetylate histones;HATs acetylate histones;HATs acetylate histones;RMTs methylate histone arginines;UCH proteinases;Ub-specific processing proteases;Metalloprotease DUBs |
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3708 319101 NA False True Keratinization;Formation of the cornified envelope |
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3709 337879 NA False True Keratinization |
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3710 337972 NA False True Keratinization |
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3711 338657 CCDC84 False True NA |
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3712 338785 NA False True Keratinization;Formation of the cornified envelope |
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3713 339287 MSL1 False True HATs acetylate histones |
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3714 339302 CPLX4 False True NA |
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3715 340156 MYLK4 False True NA |
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3716 340348 TSPAN33 False True Amyloid fiber formation |
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3717 340359 KLHL38 False True NA |
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3718 342667 STAC2 False True NA |
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3719 342979 NA False True NA |
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3720 345651 ACTBL2 False True NA |
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3721 345778 NA False True NA |
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3722 347517 RAB41 False True Intra-Golgi traffic;RAB geranylgeranylation |
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3723 347688 TUBB8 False True Translocation of SLC2A4 (GLUT4) to the plasma membrane;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;Gap junction assembly;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HSP90 chaperone cycle for steroid hormone receptors (SHR);Recruitment of NuMA to mitotic centrosomes;Recycling pathway of L1;Recycling pathway of L1;Cilium Assembly;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;Carboxyterminal post-translational modifications of tubulin;Carboxyterminal post-translational modifications of tubulin;Activation of AMPK downstream of NMDARs;Kinesins |
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3724 347733 TUBB2B False True Translocation of SLC2A4 (GLUT4) to the plasma membrane;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;Gap junction assembly;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HSP90 chaperone cycle for steroid hormone receptors (SHR);Recruitment of NuMA to mitotic centrosomes;Prefoldin mediated transfer of substrate to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Post-chaperonin tubulin folding pathway;Recycling pathway of L1;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;Carboxyterminal post-translational modifications of tubulin;Carboxyterminal post-translational modifications of tubulin;Activation of AMPK downstream of NMDARs;Kinesins |
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3725 347734 NA False True Transport and synthesis of PAPS;Transport of nucleotide sugars |
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3726 348110 NA False True NA |
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3727 353142 NA False True Formation of the cornified envelope |
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3728 373156 GSTK1 False True Glutathione conjugation;Peroxisomal protein import;Peroxisomal protein import |
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3729 374454 NA False True Keratinization;Formation of the cornified envelope |
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3730 374897 NA True False NA |
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3731 375035 NA False True NA |
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3732 375056 MIA3 False True Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Cargo concentration in the ER;Post-translational protein phosphorylation |
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3733 375248 NA False True NA |
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3734 375484 SIMC1 False True NA |
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3735 375593 NA False True NA |
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3736 378108 TRIM74 False True NA |
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3737 378884 NHLRC1 False True Glycogen synthesis;Myoclonic epilepsy of Lafora |
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3738 386617 NA False True NA |
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3739 386675 KRTAP10-7 False True Keratinization |
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3740 386676 KRTAP10-9 False True Keratinization |
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3741 386682 KRTAP10-3 False True Keratinization |
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3742 387082 SUMO4 False True NA |
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3743 387521 TMEM189 False True NA |
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3744 387522 TMEM189-UBE2V1 False True NOD1/2 Signaling Pathway;TICAM1, RIP1-mediated IKK complex recruitment ;Downstream TCR signaling;FCERI mediated NF-kB activation;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;activated TAK1 mediates p38 MAPK activation;JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1;CLEC7A (Dectin-1) signaling;Interleukin-1 signaling;IRAK1 recruits IKK complex;IKK complex recruitment mediated by RIP1;TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling;IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation;Antigen processing: Ubiquitination & Proteasome degradation |
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3745 387923 NA False True NA |
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3746 388524 NA False True NA |
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3747 388591 RNF207 False True NA |
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3748 388677 NOTCH2NL False True NA |
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3749 388697 NA True False Neutrophil degranulation |
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3750 388698 NA True False Neutrophil degranulation |
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3751 388818 KRTAP26-1 False True Keratinization |
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3752 389084 NA False True NA |
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3753 389362 PSMG4 False True NA |
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3754 389840 MAP3K15 False True NA |
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3755 390535 NA False True NA |
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3756 390637 GDPGP1 False True NA |
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3757 390916 NA False True Peroxisomal lipid metabolism;Peroxisomal protein import;Peroxisomal protein import |
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3758 397519 NA False True NA |
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3759 399396 nedd4l False True NA |
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3760 399687 MYO18A False True Signaling by cytosolic FGFR1 fusion mutants;Signaling by FGFR1 in disease |
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3761 401152 C4orf3 False True NA |
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3762 401466 NA False True NA |
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3763 401541 CENPP False True Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Deposition of new CENPA-containing nucleosomes at the centromere;Mitotic Prometaphase |
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3764 404734 NA False True NA |
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3765 414059 NA False True NA |
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3766 414318 C9orf106 False True NA |
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3767 415116 NA False True NA |
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3768 440434 NA False True NA |
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3769 440482 NA False True NA |
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3770 440574 MINOS1 False True Cristae formation |
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3771 440686 NA False True NA |
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3772 440915 POTEKP False True NA |
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3773 441282 NA False True Estrogen biosynthesis |
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3774 441518 NA False True NA |
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3775 448834 NA True False NA |
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3776 493856 CISD2 False True NA |
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3777 497049 NA False True NA |
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3778 542767 NA False True NA |
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3779 548596 CKMT1A False True Creatine metabolism |
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3780 553115 PEF1 False True NA |
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3781 554313 NA False True Meiotic synapsis;Packaging Of Telomere Ends;Pre-NOTCH Transcription and Translation;Formation of the beta-catenin:TCF transactivating complex;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;HDACs deacetylate histones;PKMTs methylate histone lysines;HDMs demethylate histones;HATs acetylate histones;HATs acetylate histones;RMTs methylate histone arginines;SIRT1 negatively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;NoRC negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;SUMOylation of chromatin organization proteins;B-WICH complex positively regulates rRNA expression;DNA methylation;Transcriptional regulation by small RNAs;Activation of anterior HOX genes in hindbrain development during early embryogenesis;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Processing of DNA double-strand break ends;Deposition of new CENPA-containing nucleosomes at the centromere;G2/M DNA damage checkpoint;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Estrogen-dependent gene expression;Meiotic recombination;Amyloid fiber formation |
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3782 574040 NA False True NA |
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3783 643752 NA False True NA |
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3784 645432 NA False True NA |
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3785 653234 NA False True NA |
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3786 653268 NA False True NA |
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3787 653404 FOXD4L6 False True NA |
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3788 653499 NA True False NA |
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3789 653505 NA False True NA |
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3790 653509 SFTPA1 False True Toll Like Receptor 4 (TLR4) Cascade;Toll Like Receptor TLR1:TLR2 Cascade;Signal regulatory protein family interactions;Surfactant metabolism;Regulation of TLR by endogenous ligand;Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5);Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4) |
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3791 654364 NME1-NME2 False True Interconversion of nucleotide di- and triphosphates;Neutrophil degranulation |
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3792 727897 MUC5B True True Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC);Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS);Defective GALNT12 causes colorectal cancer 1 (CRCS1);Dectin-2 family;O-linked glycosylation of mucins;Termination of O-glycan biosynthesis |
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3793 728642 CDK11A False True Recruitment of mitotic centrosome proteins and complexes |
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3794 729092 NA False True NA |
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3795 851752 SUP35 False True NA |
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3796 853344 GSH1 False True NA |
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3797 854708 NA False True NA |
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3798 855054 NA False True NA |
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3799 951476 NA False True NA |
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3800 2540051 NA False True NA |
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3801 100009506 ACTA1 False True NA |
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3802 100128588 LOC100128588 False True NA |
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3803 100129271 NA True False NA |
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3804 100342572 LOC100342572 False True NA |
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3805 100506742 CASP12 False True NA |
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3806 100507436 MICA False True Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
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3807 100526693 ARPC4-TTLL3 False True NA |
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3808 100526737 NA False True RUNX2 regulates bone development |
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3809 100532736 MINOS1-NBL1 False True NA |
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3810 100996928 NA False True NA |
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3811 101929876 LOC101929876 False True NA |
99f6a94c1ade
planemo upload commit 4ba1ebe7b3f5e3fabf78b5fed7ed0b92e2cbf9e5-dirty
proteore
parents:
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changeset
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3812 101930400 LOC101930400 False True NA |
99f6a94c1ade
planemo upload commit 4ba1ebe7b3f5e3fabf78b5fed7ed0b92e2cbf9e5-dirty
proteore
parents:
diff
changeset
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3813 102288414 NA False True NA |
99f6a94c1ade
planemo upload commit 4ba1ebe7b3f5e3fabf78b5fed7ed0b92e2cbf9e5-dirty
proteore
parents:
diff
changeset
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3814 NA NA True False NA |