Mercurial > repos > proteore > proteore_build_protein_interaction_maps

Entrez gene ID	Official Symbol Interactor	Present in user input ids	ID present in Biogrid Human	Pathway
2	A2M	False	True	Platelet degranulation ;Intrinsic Pathway of Fibrin Clot Formation;Degradation of the extracellular matrix;Rho GTPase cycle;HDL assembly
12	SERPINA3	True	True	Platelet degranulation ;Neutrophil degranulation
15	AANAT	False	True	Serotonin and melatonin biosynthesis
16	AARS	False	True	Cytosolic tRNA aminoacylation
18	ABAT	False	True	Degradation of GABA
25	ABL1	False	True	Regulation of actin dynamics for phagocytic cup formation;CDO in myogenesis;CDO in myogenesis;Role of ABL in ROBO-SLIT signaling;Role of ABL in ROBO-SLIT signaling;RHO GTPases Activate WASPs and WAVEs;HDR through Single Strand Annealing (SSA);Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Cyclin D associated events in G1;RUNX1 regulates transcription of genes involved in differentiation of HSCs;RUNX2 regulates osteoblast differentiation;Factors involved in megakaryocyte development and platelet production
27	ABL2	False	True	Role of ABL in ROBO-SLIT signaling;Role of ABL in ROBO-SLIT signaling
30	ACAA1	False	True	alpha-linolenic acid (ALA) metabolism;Beta-oxidation of very long chain fatty acids;Neutrophil degranulation;Peroxisomal protein import;Peroxisomal protein import;TYSND1 cleaves peroxisomal proteins
31	ACACA	False	True	ChREBP activates metabolic gene expression;Biotin transport and metabolism;Import of palmitoyl-CoA into the mitochondrial matrix;Activation of gene expression by SREBF (SREBP);Defective HLCS causes multiple carboxylase deficiency;Fatty acyl-CoA biosynthesis
34	ACADM	False	True	PPARA activates gene expression;mitochondrial fatty acid beta-oxidation of unsaturated fatty acids;Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA;Beta oxidation of octanoyl-CoA to hexanoyl-CoA
38	ACAT1	False	True	Branched-chain amino acid catabolism;Utilization of Ketone Bodies;Synthesis of Ketone Bodies
39	ACAT2	False	True	Cholesterol biosynthesis
48	ACO1	False	True	Iron uptake and transport
50	ACO2	False	True	Mitochondrial protein import;Citric acid cycle (TCA cycle)
58	ACTA1	False	True	Striated Muscle Contraction
59	ACTA2	False	True	Smooth Muscle Contraction;NOTCH4 Intracellular Domain Regulates Transcription
60	ACTB	False	True	Translocation of SLC2A4 (GLUT4) to the plasma membrane;Gap junction degradation;Formation of annular gap junctions;Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;HATs acetylate histones;Prefoldin mediated transfer of substrate  to CCT/TriC;Folding of actin by CCT/TriC;EPHB-mediated forward signaling;EPH-ephrin mediated repulsion of cells;Adherens junctions interactions;Adherens junctions interactions;Recycling pathway of L1;Recycling pathway of L1;VEGFA-VEGFR2 Pathway;Interaction between L1 and Ankyrins;Interaction between L1 and Ankyrins;Cell-extracellular matrix interactions;B-WICH complex positively regulates rRNA expression;RHO GTPases activate IQGAPs;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate Formins;RHO GTPases Activate Formins;MAP2K and MAPK activation;UCH proteinases;DNA Damage Recognition in GG-NER;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF;Clathrin-mediated endocytosis;Factors involved in megakaryocyte development and platelet production
70	ACTC1	False	True	Striated Muscle Contraction
71	ACTG1	True	True	Translocation of SLC2A4 (GLUT4) to the plasma membrane;Gap junction degradation;Formation of annular gap junctions;Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;EPHB-mediated forward signaling;EPH-ephrin mediated repulsion of cells;Adherens junctions interactions;Adherens junctions interactions;Recycling pathway of L1;Recycling pathway of L1;VEGFA-VEGFR2 Pathway;Interaction between L1 and Ankyrins;Interaction between L1 and Ankyrins;Cell-extracellular matrix interactions;RHO GTPases activate IQGAPs;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate Formins;RHO GTPases Activate Formins;MAP2K and MAPK activation;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF;Clathrin-mediated endocytosis
81	ACTN4	True	True	Platelet degranulation ;Nephrin family interactions
87	ACTN1	False	True	Platelet degranulation ;Syndecan interactions;Nephrin family interactions;Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
88	ACTN2	False	True	Platelet degranulation ;Nephrin family interactions;Striated Muscle Contraction;Unblocking of NMDA receptors, glutamate binding and activation;Unblocking of NMDA receptors, glutamate binding and activation;Ras activation upon Ca2+ influx through NMDA receptor;RAF/MAP kinase cascade;Negative regulation of NMDA receptor-mediated neuronal transmission;Long-term potentiation
89	ACTN3	False	True	Nephrin family interactions;Striated Muscle Contraction
91	ACVR1B	False	True	Signaling by NODAL;Regulation of signaling by NODAL;Signaling by Activin
93	ACVR2B	False	True	Signaling by NODAL;Regulation of signaling by NODAL;Signaling by Activin;Signaling by Activin;Signaling by BMP
95	ACY1	False	True	Aflatoxin activation and detoxification;Defective ACY1 causes encephalopathy
115	NA	False	True	Glucagon signaling in metabolic regulation;PKA activation;PKA activation in glucagon signalling;Adenylate cyclase activating pathway;Adenylate cyclase inhibitory pathway;Adenylate cyclase inhibitory pathway;G alpha (s) signalling events;G alpha (s) signalling events;G alpha (i) signalling events;G alpha (z) signalling events;G alpha (z) signalling events;Vasopressin regulates renal water homeostasis via Aquaporins;Hedgehog 'off' state
119	ADD2	False	True	Miscellaneous transport and binding events
120	NA	False	True	Miscellaneous transport and binding events
125	ADH1B	False	True	Ethanol oxidation
127	ADH4	False	True	RA biosynthesis pathway;Ethanol oxidation
132	ADK	False	True	Purine salvage
140	ADORA3	False	True	Adenosine P1 receptors;G alpha (i) signalling events
142	PARP1	False	True	POLB-Dependent Long Patch Base Excision Repair;Downregulation of SMAD2/3:SMAD4 transcriptional activity;SUMOylation of DNA damage response and repair proteins;HDR through MMEJ (alt-NHEJ);DNA Damage Recognition in GG-NER;Formation of Incision Complex in GG-NER;Dual Incision in GG-NER
147	ADRA1B	False	True	Adrenoceptors;G alpha (q) signalling events;G alpha (12/13) signalling events
157	ADRBK2	False	True	G alpha (s) signalling events;Cargo recognition for clathrin-mediated endocytosis
158	ADSL	False	True	Purine ribonucleoside monophosphate biosynthesis
159	ADSS	False	True	Purine ribonucleoside monophosphate biosynthesis
160	AP2A1	False	True	Nef Mediated CD4 Down-regulation;Retrograde neurotrophin signalling;Retrograde neurotrophin signalling;Nef Mediated CD8 Down-regulation;MHC class II antigen presentation;EPH-ephrin mediated repulsion of cells;Trafficking of GluR2-containing AMPA receptors;Recycling pathway of L1;Recycling pathway of L1;WNT5A-dependent internalization of FZD4;WNT5A-dependent internalization of FZD2, FZD5 and ROR2;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;VLDLR internalisation and degradation;LDL clearance
163	AP2B1	False	True	Nef Mediated CD4 Down-regulation;Retrograde neurotrophin signalling;Retrograde neurotrophin signalling;Nef Mediated CD8 Down-regulation;MHC class II antigen presentation;EPH-ephrin mediated repulsion of cells;Trafficking of GluR2-containing AMPA receptors;Recycling pathway of L1;Recycling pathway of L1;WNT5A-dependent internalization of FZD4;WNT5A-dependent internalization of FZD2, FZD5 and ROR2;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;VLDLR internalisation and degradation;LDL clearance
164	AP1G1	False	True	Nef mediated downregulation of MHC class I complex cell surface expression;MHC class II antigen presentation;Lysosome Vesicle Biogenesis;Golgi Associated Vesicle Biogenesis
166	AES	False	True	Repression of WNT target genes
175	AGA	True	True	Neutrophil degranulation
178	AGL	False	True	Neutrophil degranulation;Glycogen breakdown (glycogenolysis)
189	NA	False	True	Glyoxylate metabolism and glycine degradation;Peroxisomal protein import;Peroxisomal protein import
191	AHCY	False	True	Methylation;Sulfur amino acid metabolism;Metabolism of ingested SeMet, Sec, MeSec into H2Se;Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD)
196	AHR	False	True	PPARA activates gene expression;Phase I - Functionalization of compounds;Endogenous sterols;Xenobiotics;Aryl hydrocarbon receptor signalling
197	AHSG	False	True	Platelet degranulation ;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Neutrophil degranulation;Post-translational protein phosphorylation
204	AK2	False	True	Interconversion of nucleotide di- and triphosphates
207	AKT1	False	True	Activation of BAD and translocation to mitochondria ;PIP3 activates AKT signaling;PIP3 activates AKT signaling;Downregulation of ERBB2:ERBB3 signaling;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation;mTOR signalling;AKT phosphorylates targets in the cytosol;AKT phosphorylates targets in the cytosol;AKT phosphorylates targets in the nucleus;Negative regulation of the PI3K/AKT network;eNOS activation;AKT-mediated inactivation of FOXO1A;Integrin alphaIIb beta3 signaling;Deactivation of the beta-catenin transactivating complex;CD28 dependent PI3K/Akt signaling;CTLA4 inhibitory signaling;G beta:gamma signalling through PI3Kgamma;Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA;KSRP (KHSRP) binds and destabilizes mRNA;VEGFR2 mediated vascular permeability;TP53 Regulates Metabolic Genes;Constitutive Signaling by AKT1 E17K in Cancer;Interleukin-4 and Interleukin-13 signaling;Regulation of TP53 Degradation;Regulation of TP53 Activity through Acetylation;Regulation of TP53 Activity through Association with Co-factors;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Cyclin E associated events during G1/S transition ;Cyclin A:Cdk2-associated events at S phase entry;PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1;RAB GEFs exchange GTP for GDP on RABs;RUNX2 regulates genes involved in cell migration;Regulation of PTEN stability and activity;Negative regulation of NOTCH4 signaling;Regulation of localization of FOXO transcription factors
208	AKT2	False	True	Activation of BAD and translocation to mitochondria ;PIP3 activates AKT signaling;PIP3 activates AKT signaling;Downregulation of ERBB2:ERBB3 signaling;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Activation of AKT2;PDE3B signalling;Inhibition of TSC complex formation by PKB;AKT phosphorylates targets in the cytosol;AKT phosphorylates targets in the cytosol;AKT phosphorylates targets in the nucleus;Negative regulation of the PI3K/AKT network;AKT-mediated inactivation of FOXO1A;Deactivation of the beta-catenin transactivating complex;CD28 dependent PI3K/Akt signaling;CTLA4 inhibitory signaling;G beta:gamma signalling through PI3Kgamma;VEGFR2 mediated vascular permeability;TP53 Regulates Metabolic Genes;Constitutive Signaling by AKT1 E17K in Cancer;Regulation of TP53 Degradation;Regulation of TP53 Activity through Acetylation;Regulation of TP53 Activity through Association with Co-factors;Cyclin E associated events during G1/S transition ;Cyclin A:Cdk2-associated events at S phase entry;RAB GEFs exchange GTP for GDP on RABs;RUNX2 regulates genes involved in cell migration;Regulation of PTEN stability and activity;Regulation of localization of FOXO transcription factors
210	ALAD	False	True	Heme biosynthesis;Neutrophil degranulation
213	ALB	True	True	Platelet degranulation ;Recycling of bile acids and salts;Scavenging of heme from plasma;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR);Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR);Transport of organic anions;Post-translational protein phosphorylation;HDL remodeling
214	ALCAM	False	True	L1CAM interactions
217	ALDH2	False	True	Metabolism of serotonin;Ethanol oxidation
219	ALDH1B1	False	True	Ethanol oxidation
224	ALDH3A2	False	True	Sphingolipid de novo biosynthesis;Alpha-oxidation of phytanate
226	ALDOA	True	True	Platelet degranulation ;Neutrophil degranulation;Glycolysis;Gluconeogenesis
229	ALDOB	False	True	Hereditary fructose intolerance;Glycolysis;Gluconeogenesis;Fructose catabolism
230	ALDOC	True	True	Neutrophil degranulation;Glycolysis;Gluconeogenesis
231	AKR1B1	False	True	Pregnenolone biosynthesis;Fructose biosynthesis
238	ALK	False	True	NA
242	NA	True	False	Synthesis of 12-eicosatetraenoic acid derivatives
248	ALPI	False	True	Synthesis of PA;Post-translational modification: synthesis of GPI-anchored proteins;Digestion
262	AMD1	False	True	Metabolism of polyamines
267	AMFR	False	True	N-glycan trimming in the ER and Calnexin/Calreticulin cycle;ER Quality Control Compartment (ERQC)
269	AMHR2	False	True	Signaling by BMP
272	NA	False	True	Neutrophil degranulation;Purine salvage
274	BIN1	False	True	Clathrin-mediated endocytosis
275	NA	False	True	Glycine degradation
276	AMY1A	True	True	Digestion of dietary carbohydrate
277	NA	True	False	Digestion of dietary carbohydrate
278	NA	True	False	Digestion of dietary carbohydrate
286	ANK1	False	True	Interaction between L1 and Ankyrins;Interaction between L1 and Ankyrins;NrCAM interactions;CHL1 interactions;Neurofascin interactions;Neurofascin interactions;COPI-mediated anterograde transport
292	SLC25A5	False	True	Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization;Regulation of insulin secretion
293	SLC25A6	False	True	Mitochondrial protein import;Mitochondrial protein import;Influenza Virus Induced Apoptosis;Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization;Regulation of insulin secretion
301	ANXA1	True	True	G alpha (q) signalling events;G alpha (i) signalling events;Formyl peptide receptors bind formyl peptides and many other ligands;Smooth Muscle Contraction;Interleukin-4 and Interleukin-13 signaling
302	ANXA2	True	True	Smooth Muscle Contraction;Neutrophil degranulation;Dissolution of Fibrin Clot;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
307	ANXA4	False	True	NA
308	ANXA5	False	True	Platelet degranulation
309	ANXA6	False	True	Smooth Muscle Contraction
310	ANXA7	False	True	NA
312	ANXA13	False	True	NA
317	APAF1	False	True	Formation of apoptosome;Activation of caspases through apoptosome-mediated cleavage;SMAC (DIABLO) binds to IAPs ;SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ;Neutrophil degranulation;TP53 Regulates Transcription of Caspase Activators and Caspases;Transcriptional Regulation by E2F6;Regulation of the apoptosome activity;Regulation of the apoptosome activity
322	APBB1	False	True	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
324	APC	False	True	Apoptotic cleavage of cellular proteins;Degradation of beta-catenin by the destruction complex;Beta-catenin phosphorylation cascade;Deactivation of the beta-catenin transactivating complex;Disassembly of the destruction complex and recruitment of AXIN to the membrane;Disassembly of the destruction complex and recruitment of AXIN to the membrane;Misspliced GSK3beta mutants stabilize beta-catenin;S33 mutants of beta-catenin aren't phosphorylated;S37 mutants of beta-catenin aren't phosphorylated;S45 mutants of beta-catenin aren't phosphorylated;T41 mutants of beta-catenin aren't phosphorylated;APC truncation mutants are not K63 polyubiquitinated;APC truncation mutants have impaired AXIN binding;AXIN missense mutants destabilize the destruction complex;Truncations of AMER1 destabilize the destruction complex;Ovarian tumor domain proteases
328	APEX1	False	True	Displacement of DNA glycosylase by APEX1;POLB-Dependent Long Patch Base Excision Repair;Resolution of AP sites via the multiple-nucleotide patch replacement pathway;PCNA-Dependent Long Patch Base Excision Repair;Abasic sugar-phosphate removal via the single-nucleotide replacement pathway;Resolution of Abasic Sites (AP sites)
332	BIRC5	False	True	Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;SUMOylation of DNA replication proteins;RHO GTPases Activate Formins;Interleukin-4 and Interleukin-13 signaling;TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain;Mitotic Prometaphase;Neddylation
333	APLP1	False	True	NA
334	APLP2	False	True	Platelet degranulation ;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation
335	APOA1	False	True	Platelet degranulation ;ABC transporters in lipid homeostasis;PPARA activates gene expression;Scavenging of heme from plasma;Scavenging by Class B Receptors;Scavenging by Class B Receptors;Scavenging by Class A Receptors;Scavenging by Class A Receptors;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation;Chylomicron assembly;HDL assembly;Chylomicron remodeling;HDL clearance;HDL remodeling;Retinoid metabolism and transport;Retinoid metabolism and transport;Amyloid fiber formation
336	APOA2	False	True	PPARA activates gene expression;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation;Chylomicron assembly;Chylomicron remodeling;Retinoid metabolism and transport;Retinoid metabolism and transport
337	NA	False	True	NA
338	APOB	False	True	Cell surface interactions at the vascular wall;Scavenging by Class B Receptors;Scavenging by Class B Receptors;Scavenging by Class A Receptors;Scavenging by Class A Receptors;Scavenging by Class F Receptors;Scavenging by Class F Receptors;Scavenging by Class H Receptors;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Platelet sensitization by LDL;Regulation of TLR by endogenous ligand;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;VLDL assembly;Post-translational protein phosphorylation;Chylomicron assembly;Chylomicron remodeling;Chylomicron clearance;Chylomicron clearance;LDL clearance;LDL clearance;LDL remodeling;VLDL clearance;VLDL clearance;Retinoid metabolism and transport;Retinoid metabolism and transport
341	APOC1	False	True	VLDL assembly;VLDL clearance;VLDL clearance
344	APOC2	False	True	Chylomicron assembly;Assembly of active LPL and LIPC lipase complexes;Chylomicron remodeling;HDL remodeling;Retinoid metabolism and transport;Retinoid metabolism and transport
345	APOC3	False	True	Chylomicron assembly;Chylomicron remodeling;HDL remodeling;Retinoid metabolism and transport;Retinoid metabolism and transport
347	APOD	True	True	Transport of fatty acids
348	APOE	False	True	Scavenging by Class A Receptors;Scavenging by Class A Receptors;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors;Post-translational protein phosphorylation;Chylomicron assembly;Chylomicron remodeling;Chylomicron clearance;Chylomicron clearance;HDL remodeling;Retinoid metabolism and transport;Retinoid metabolism and transport
350	APOH	False	True	Platelet degranulation
351	APP	False	True	Platelet degranulation ;ECM proteoglycans;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);G alpha (q) signalling events;G alpha (i) signalling events;Lysosome Vesicle Biogenesis;Formyl peptide receptors bind formyl peptides and many other ligands;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;The NLRP3 inflammasome;Advanced glycosylation endproduct receptor signaling;Advanced glycosylation endproduct receptor signaling;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Post-translational protein phosphorylation;TRAF6 mediated NF-kB activation;Amyloid fiber formation
353	APRT	False	True	Neutrophil degranulation;Purine salvage
354	KLK3	False	True	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
357	NA	False	True	NA
358	AQP1	False	True	Erythrocytes take up carbon dioxide and release oxygen;Erythrocytes take up oxygen and release carbon dioxide;Vasopressin regulates renal water homeostasis via Aquaporins;Passive transport by Aquaporins
360	AQP3	False	True	Vasopressin regulates renal water homeostasis via Aquaporins;Passive transport by Aquaporins
367	AR	False	True	HSP90 chaperone cycle for steroid hormone receptors (SHR);Nuclear Receptor transcription pathway;SUMOylation of intracellular receptors;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Ub-specific processing proteases;RUNX2 regulates osteoblast differentiation;RUNX2 regulates osteoblast differentiation
369	ARAF	False	True	RAF activation;MAP2K and MAPK activation;Negative regulation of MAPK pathway;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF
372	ARCN1	False	True	COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic
373	TRIM23	False	True	NA
378	ARF4	False	True	VxPx cargo-targeting to cilium;VxPx cargo-targeting to cilium;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic
381	ARF5	False	True	COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic
383	ARG1	True	True	Neutrophil degranulation;Urea cycle
384	ARG2	False	True	Urea cycle
387	RHOA	False	True	GPVI-mediated activation cascade;Axonal growth inhibition (RHOA activation);Rho GTPase cycle;PI3K/AKT activation;Axonal growth stimulation;TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);G beta:gamma signalling through PI3Kgamma;EPHB-mediated forward signaling;EPHB-mediated forward signaling;EPHA-mediated growth cone collapse;EPHA-mediated growth cone collapse;PCP/CE pathway;G alpha (12/13) signalling events;Sema4D mediated inhibition of cell attachment and migration;Sema4D induced cell migration and growth-cone collapse;Sema4D induced cell migration and growth-cone collapse;VEGFA-VEGFR2 Pathway;RHO GTPases activate PKNs;RHO GTPases activate CIT;RHO GTPases activate CIT;RHO GTPases activate KTN1;RHO GTPases Activate ROCKs;RHO GTPases Activate ROCKs;RHO GTPases Activate Formins;RHO GTPases Activate Rhotekin and Rhophilins;RHO GTPases Activate Rhotekin and Rhophilins;Ovarian tumor domain proteases;ERBB2 Regulates Cell Motility;Neutrophil degranulation;PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases;SLIT2:ROBO1 increases RHOA activity
390	RND3	False	True	NA
396	ARHGDIA	False	True	Axonal growth inhibition (RHOA activation);Rho GTPase cycle;Axonal growth stimulation
398	ARHGDIG	False	True	Rho GTPase cycle
405	ARNT	False	True	Regulation of gene expression by Hypoxia-inducible Factor;PPARA activates gene expression;Phase I - Functionalization of compounds;Endogenous sterols;Xenobiotics;Aryl hydrocarbon receptor signalling
406	ARNTL	False	True	BMAL1:CLOCK,NPAS2 activates circadian gene expression;BMAL1:CLOCK,NPAS2 activates circadian gene expression;PPARA activates gene expression;Circadian Clock
427	ASAH1	False	True	Glycosphingolipid metabolism;Neutrophil degranulation
432	ASGR1	False	True	Asparagine N-linked glycosylation
439	ASNA1	False	True	XBP1(S) activates chaperone genes
440	ASNS	False	True	ATF4 activates genes;Amino acid synthesis and interconversion (transamination)
444	ASPH	False	True	Stimuli-sensing channels;Ion homeostasis
445	ASS1	False	True	Urea cycle
466	ATF1	False	True	CREB phosphorylation
467	ATF3	False	True	ATF4 activates genes
471	ATIC	False	True	Purine ribonucleoside monophosphate biosynthesis
472	ATM	False	True	DNA Damage/Telomere Stress Induced Senescence;Regulation of HSF1-mediated heat shock response;Autodegradation of the E3 ubiquitin ligase COP1;HDR through Single Strand Annealing (SSA);HDR through Homologous Recombination (HRR);Sensing of DNA Double Strand Breaks;Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA);Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Resolution of D-loop Structures through Holliday Junction Intermediates;Nonhomologous End-Joining (NHEJ);Homologous DNA Pairing and Strand Exchange;Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;TP53 Regulates Transcription of DNA Repair Genes;TP53 Regulates Transcription of Genes Involved in Cytochrome C Release;TP53 Regulates Transcription of Caspase Activators and Caspases;Regulation of TP53 Activity through Phosphorylation;Regulation of TP53 Degradation;Regulation of TP53 Activity through Methylation;G2/M DNA damage checkpoint;Stabilization of p53;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Meiotic recombination
475	ATOX1	False	True	Detoxification of Reactive Oxygen Species;Ion influx/efflux at host-pathogen interface
476	ATP1A1	False	True	Ion homeostasis;Ion transport by P-type ATPases
488	ATP2A2	False	True	Pre-NOTCH Processing in Golgi;Reduction of cytosolic Ca++ levels;Ion homeostasis;Ion transport by P-type ATPases
491	ATP2B2	False	True	Reduction of cytosolic Ca++ levels;Ion homeostasis;Ion transport by P-type ATPases
493	ATP2B4	False	True	Reduction of cytosolic Ca++ levels;Ion homeostasis;Ion transport by P-type ATPases
498	ATP5A1	True	True	Mitochondrial protein import;Formation of ATP by chemiosmotic coupling;Cristae formation
501	ALDH7A1	False	True	Choline catabolism;Lysine catabolism
506	ATP5B	False	True	Mitochondrial protein import;Mitochondrial protein import;Formation of ATP by chemiosmotic coupling;Transcriptional activation of mitochondrial biogenesis;Cristae formation
509	ATP5C1	False	True	Formation of ATP by chemiosmotic coupling;Cristae formation
513	ATP5D	False	True	Formation of ATP by chemiosmotic coupling;Cristae formation
514	ATP5E	False	True	Formation of ATP by chemiosmotic coupling;Cristae formation
515	ATP5F1	False	True	Formation of ATP by chemiosmotic coupling;Cristae formation
521	ATP5I	False	True	Formation of ATP by chemiosmotic coupling;Cristae formation
522	ATP5J	False	True	Formation of ATP by chemiosmotic coupling;Cristae formation
523	ATP6V1A	False	True	ROS, RNS production in phagocytes;Insulin receptor recycling;Transferrin endocytosis and recycling;Ion channel transport
525	ATP6V1B1	False	True	ROS, RNS production in phagocytes;Insulin receptor recycling;Transferrin endocytosis and recycling;Ion channel transport
526	ATP6V1B2	False	True	ROS, RNS production in phagocytes;Insulin receptor recycling;Transferrin endocytosis and recycling;Ion channel transport
527	ATP6V0C	False	True	ROS, RNS production in phagocytes;Neutrophil degranulation;Insulin receptor recycling;Transferrin endocytosis and recycling;Ion channel transport
533	ATP6V0B	False	True	ROS, RNS production in phagocytes;Insulin receptor recycling;Transferrin endocytosis and recycling;Ion channel transport
539	ATP5O	False	True	Formation of ATP by chemiosmotic coupling;Cristae formation
545	ATR	False	True	Meiotic synapsis;Activation of ATR in response to replication stress;Regulation of HSF1-mediated heat shock response;HDR through Single Strand Annealing (SSA);Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;Fanconi Anemia Pathway;TP53 Regulates Transcription of DNA Repair Genes;Regulation of TP53 Activity through Phosphorylation;G2/M DNA damage checkpoint
558	AXL	False	True	VEGFA-VEGFR2 Pathway
563	AZGP1	True	True	Miscellaneous transport and binding events
572	BAD	False	True	Activation of BAD and translocation to mitochondria ;Activation of BAD and translocation to mitochondria ;BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members;NRAGE signals death through JNK;AKT phosphorylates targets in the cytosol;Constitutive Signaling by AKT1 E17K in Cancer
573	BAG1	False	True	Regulation of HSF1-mediated heat shock response
581	BAX	False	True	Release of apoptotic factors from the mitochondria;Activation, translocation and oligomerization of BAX;TP53 Regulates Transcription of Genes Involved in Cytochrome C Release;TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest;Transcriptional regulation by RUNX2;NTRK3 as a dependence receptor
587	BCAT2	False	True	Branched-chain amino acid catabolism
593	BCKDHA	False	True	Glyoxylate metabolism and glycine degradation;Branched-chain amino acid catabolism
595	CCND1	False	True	SCF(Skp2)-mediated degradation of p27/p21;Pre-NOTCH Transcription and Translation;RMTs methylate histone arginines;Interleukin-4 and Interleukin-13 signaling;Ubiquitin-dependent degradation of Cyclin D1;Ubiquitin-dependent degradation of Cyclin D1;Cyclin D associated events in G1;PTK6 Regulates Cell Cycle;Transcriptional regulation by RUNX2;Regulation of RUNX1 Expression and Activity;RUNX3 regulates WNT signaling;RUNX3 regulates p14-ARF;Estrogen-dependent gene expression
596	BCL2	False	True	Activation of BAD and translocation to mitochondria ;BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members;Interleukin-4 and Interleukin-13 signaling;The NLRP1 inflammasome;Estrogen-dependent gene expression
599	BCL2L2	False	True	NA
604	BCL6	False	True	Interleukin-4 and Interleukin-13 signaling;TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain;FOXO-mediated transcription of cell death genes
613	BCR	False	True	Signaling by cytosolic FGFR1 fusion mutants;Rho GTPase cycle;Signaling by FGFR1 in disease
622	BDH1	False	True	Utilization of Ketone Bodies;Synthesis of Ketone Bodies
629	CFB	False	True	Alternative complement activation;Activation of C3 and C5;Regulation of Complement cascade
639	PRDM1	False	True	Regulation of TP53 Expression
640	BLK	False	True	RUNX1 regulates transcription of genes involved in BCR signaling;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
641	BLM	False	True	SUMOylation of DNA damage response and repair proteins;HDR through Single Strand Annealing (SSA);HDR through Homologous Recombination (HRR);Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA);Resolution of D-loop Structures through Holliday Junction Intermediates;Homologous DNA Pairing and Strand Exchange;Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;Regulation of TP53 Activity through Phosphorylation;G2/M DNA damage checkpoint;Meiotic recombination
642	BLMH	True	True	Antigen processing: Ubiquitination & Proteasome degradation
655	BMP7	False	True	Molecules associated with elastic fibres
657	BMPR1A	False	True	Signaling by BMP
660	BMX	False	True	Apoptotic cleavage of cellular proteins;Synthesis of PIPs at the plasma membrane
663	BNIP2	False	True	CDO in myogenesis;CDO in myogenesis
664	BNIP3	False	True	NA
665	BNIP3L	False	True	TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
667	DST	False	True	Assembly of collagen fibrils and other multimeric structures;Type I hemidesmosome assembly
672	BRCA1	False	True	Meiotic synapsis;SUMOylation of DNA damage response and repair proteins;HDR through Single Strand Annealing (SSA);HDR through Homologous Recombination (HRR);Metalloprotease DUBs;Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA);Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Resolution of D-loop Structures through Holliday Junction Intermediates;Nonhomologous End-Joining (NHEJ);Homologous DNA Pairing and Strand Exchange;Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;TP53 Regulates Transcription of DNA Repair Genes;Regulation of TP53 Activity through Phosphorylation;G2/M DNA damage checkpoint;Transcriptional Regulation by E2F6;Meiotic recombination
673	BRAF	False	True	Spry regulation of FGF signaling;Frs2-mediated activation;ARMS-mediated activation;Signalling to p38 via RIT and RIN;RAF activation;MAP2K and MAPK activation;Negative feedback regulation of MAPK pathway;Negative regulation of MAPK pathway;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF
678	ZFP36L2	False	True	NA
695	BTK	False	True	ER-Phagosome pathway;MyD88:MAL(TIRAP) cascade initiated on plasma membrane;Regulation of actin dynamics for phagocytic cup formation;DAP12 signaling;FCERI mediated Ca+2 mobilization;FCERI mediated Ca+2 mobilization;G alpha (q) signalling events;G alpha (12/13) signalling events;MyD88 deficiency (TLR2/4);IRAK4 deficiency (TLR2/4);RHO GTPases Activate WASPs and WAVEs;G beta:gamma signalling through BTK;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
705	BYSL	False	True	Major pathway of rRNA processing in the nucleolus and cytosol
706	TSPO	False	True	Pregnenolone biosynthesis
708	C1QBP	False	True	Intrinsic Pathway of Fibrin Clot Formation
710	SERPING1	False	True	Platelet degranulation ;Intrinsic Pathway of Fibrin Clot Formation;Regulation of Complement cascade
720	C4A	False	True	Initial triggering of complement;Activation of C3 and C5;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation;Regulation of Complement cascade
727	C5	False	True	Terminal pathway of complement;Activation of C3 and C5;Peptide ligand-binding receptors;G alpha (i) signalling events;Regulation of Complement cascade
763	CA5A	False	True	Reversible hydration of carbon dioxide
780	DDR1	False	True	Non-integrin membrane-ECM interactions
786	CACNG1	False	True	Phase 0 - rapid depolarisation;Phase 2 - plateau phase
790	CAD	False	True	Pyrimidine biosynthesis
800	CALD1	False	True	Smooth Muscle Contraction
801	CALM1	False	True	CaMK IV-mediated phosphorylation of CREB;CaMK IV-mediated phosphorylation of CREB;Calmodulin induced events;Cam-PDE 1 activation;CaM pathway;Platelet degranulation ;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation;PKA activation;DARPP-32 events;Synthesis of IP3 and IP4 in the cytosol;Calcineurin activates NFAT;Calcineurin activates NFAT;eNOS activation;Transcriptional activation of mitochondrial biogenesis;Inactivation, recovery and regulation of the phototransduction cascade;Inactivation, recovery and regulation of the phototransduction cascade;Stimuli-sensing channels;FCERI mediated Ca+2 mobilization;FCERI mediated Ca+2 mobilization;Ca2+ pathway;Reduction of cytosolic Ca++ levels;Sodium/Calcium exchangers;Unblocking of NMDA receptors, glutamate binding and activation;CREB1 phosphorylation through the activation of Adenylate Cyclase;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;Ras activation upon Ca2+ influx through NMDA receptor;Smooth Muscle Contraction;Smooth Muscle Contraction;Activation of Ca-permeable Kainate Receptor;Uptake and function of anthrax toxins;VEGFR2 mediated vascular permeability;VEGFR2 mediated cell proliferation;Phase 0 - rapid depolarisation;Ion homeostasis;CLEC7A (Dectin-1) induces NFAT activation;CLEC7A (Dectin-1) induces NFAT activation;RHO GTPases activate IQGAPs;RHO GTPases activate PAKs;RHO GTPases activate PAKs;RAF activation;RAF/MAP kinase cascade;Signaling by moderate kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF;Glycogen breakdown (glycogenolysis);Glycogen breakdown (glycogenolysis);Protein methylation;Loss of phosphorylation of MECP2 at T308;Regulation of MECP2 expression and activity;Ion transport by P-type ATPases;Negative regulation of NMDA receptor-mediated neuronal transmission;Activation of RAC1 downstream of NMDARs;Activation of RAC1 downstream of NMDARs;Activation of AMPK downstream of NMDARs;Long-term potentiation;Long-term potentiation;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
810	CALML3	True	True	NA
811	CALR	False	True	ER-Phagosome pathway;Assembly of Viral Components at the Budding Site;Scavenging by Class A Receptors;Scavenging by Class A Receptors;Scavenging by Class F Receptors;Scavenging by Class F Receptors;ATF6 (ATF6-alpha) activates chaperone genes;Calnexin/calreticulin cycle;Antigen Presentation: Folding, assembly and peptide loading of class I MHC
813	CALU	False	True	Platelet degranulation ;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation
814	CAMK4	False	True	CaMK IV-mediated phosphorylation of CREB;CaMK IV-mediated phosphorylation of CREB;Transcriptional activation of mitochondrial biogenesis;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;Loss of phosphorylation of MECP2 at T308;Regulation of MECP2 expression and activity;Negative regulation of NMDA receptor-mediated neuronal transmission
815	CAMK2A	False	True	CaMK IV-mediated phosphorylation of CREB;HSF1-dependent transactivation;Trafficking of AMPA receptors;Ca2+ pathway;Unblocking of NMDA receptors, glutamate binding and activation;Phase 0 - rapid depolarisation;Ion homeostasis;RAF activation;Signaling by moderate kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF;Interferon gamma signaling;Regulation of MECP2 expression and activity;Ion transport by P-type ATPases;Negative regulation of NMDA receptor-mediated neuronal transmission;Long-term potentiation
816	CAMK2B	False	True	CaMK IV-mediated phosphorylation of CREB;HSF1-dependent transactivation;Trafficking of AMPA receptors;Unblocking of NMDA receptors, glutamate binding and activation;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;Phase 0 - rapid depolarisation;Ion homeostasis;RAF activation;Signaling by moderate kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF;Interferon gamma signaling;Regulation of MECP2 expression and activity;Ion transport by P-type ATPases;Negative regulation of NMDA receptor-mediated neuronal transmission;Long-term potentiation
817	CAMK2D	False	True	CaMK IV-mediated phosphorylation of CREB;HSF1-dependent transactivation;Trafficking of AMPA receptors;Unblocking of NMDA receptors, glutamate binding and activation;Phase 0 - rapid depolarisation;Ion homeostasis;RAF activation;Signaling by moderate kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF;Interferon gamma signaling;Regulation of MECP2 expression and activity;Ion transport by P-type ATPases;Negative regulation of NMDA receptor-mediated neuronal transmission;Long-term potentiation
818	CAMK2G	False	True	CaMK IV-mediated phosphorylation of CREB;HSF1-dependent transactivation;Trafficking of AMPA receptors;Unblocking of NMDA receptors, glutamate binding and activation;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;Phase 0 - rapid depolarisation;Ion homeostasis;RAF activation;Signaling by moderate kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF;Interferon gamma signaling;Regulation of MECP2 expression and activity;Ion transport by P-type ATPases;Negative regulation of NMDA receptor-mediated neuronal transmission;Long-term potentiation
819	CAMLG	False	True	NA
821	CANX	False	True	Assembly of Viral Components at the Budding Site;MHC class II antigen presentation;Interleukin-35 Signalling;Calnexin/calreticulin cycle;Interleukin-27 signaling;Antigen Presentation: Folding, assembly and peptide loading of class I MHC;Antigen Presentation: Folding, assembly and peptide loading of class I MHC
822	CAPG	True	True	NA
823	CAPN1	True	True	Degradation of the extracellular matrix;Degradation of the extracellular matrix;Neutrophil degranulation;Formation of the cornified envelope;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
824	CAPN2	False	True	Degradation of the extracellular matrix;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
826	CAPNS1	False	True	Degradation of the extracellular matrix;Degradation of the extracellular matrix;Formation of the cornified envelope;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
829	CAPZA1	False	True	MHC class II antigen presentation;HSP90 chaperone cycle for steroid hormone receptors (SHR);COPI-mediated anterograde transport;COPI-independent Golgi-to-ER retrograde traffic;Advanced glycosylation endproduct receptor signaling;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation;Factors involved in megakaryocyte development and platelet production;Factors involved in megakaryocyte development and platelet production
830	CAPZA2	False	True	MHC class II antigen presentation;HSP90 chaperone cycle for steroid hormone receptors (SHR);COPI-mediated anterograde transport;COPI-independent Golgi-to-ER retrograde traffic;Advanced glycosylation endproduct receptor signaling;Factors involved in megakaryocyte development and platelet production;Factors involved in megakaryocyte development and platelet production
831	CAST	False	True	Degradation of the extracellular matrix;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
832	CAPZB	True	True	MHC class II antigen presentation;HSP90 chaperone cycle for steroid hormone receptors (SHR);COPI-mediated anterograde transport;COPI-independent Golgi-to-ER retrograde traffic;Factors involved in megakaryocyte development and platelet production;Factors involved in megakaryocyte development and platelet production
833	CARS	False	True	Cytosolic tRNA aminoacylation
834	CASP1	False	True	NOD1/2 Signaling Pathway;Interleukin-1 processing;TP53 Regulates Transcription of Caspase Activators and Caspases;The NLRP3 inflammasome;The AIM2 inflammasome;The IPAF inflammasome;Interleukin-37 signaling
835	CASP2	False	True	NOD1/2 Signaling Pathway;NADE modulates death signalling;TP53 Regulates Transcription of Caspase Activators and Caspases
836	CASP3	False	True	Activation of caspases through apoptosome-mediated cleavage;SMAC (DIABLO) binds to IAPs ;SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ;Apoptotic cleavage of cellular proteins;SMAC, XIAP-regulated apoptotic response;Degradation of the extracellular matrix;Signaling by Hippo;NADE modulates death signalling;Activation of DNA fragmentation factor;Stimulation of the cell death response by PAK-2p34;Caspase-mediated cleavage of cytoskeletal proteins;Apoptotic cleavage of cell adhesion  proteins;Caspase activation via Dependence Receptors in the absence of ligand;Caspase activation via Dependence Receptors in the absence of ligand;Other interleukin signaling
837	CASP4	False	True	NOD1/2 Signaling Pathway
840	CASP7	False	True	Activation of caspases through apoptosome-mediated cleavage;SMAC (DIABLO) binds to IAPs ;SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ;Apoptotic cleavage of cellular proteins;SMAC, XIAP-regulated apoptotic response;Caspase-mediated cleavage of cytoskeletal proteins
841	CASP8	False	True	Apoptotic cleavage of cellular proteins;Caspase activation via Death Receptors in the presence of ligand;NOD1/2 Signaling Pathway;TRIF-mediated programmed cell death;Caspase-mediated cleavage of cytoskeletal proteins;Regulation by c-FLIP;RIPK1-mediated regulated necrosis;CASP8 activity is inhibited;TNFR1-induced proapoptotic signaling;Regulation of TNFR1 signaling;CLEC7A/inflammasome pathway;Regulation of necroptotic cell death;Dimerization of procaspase-8;Activation, myristolyation of BID and translocation to mitochondria;Apoptotic execution phase;FasL/ CD95L signaling;TRAIL  signaling;TLR3-mediated TICAM1-dependent programmed cell death;NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
843	CASP10	False	True	TP53 Regulates Transcription of Caspase Activators and Caspases;FasL/ CD95L signaling;TRAIL  signaling;NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
847	CAT	True	True	Detoxification of Reactive Oxygen Species;Neutrophil degranulation;Peroxisomal protein import;Peroxisomal protein import;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
857	CAV1	False	True	Triglyceride catabolism;eNOS activation;NOSTRIN mediated eNOS trafficking;Basigin interactions;Disassembly of the destruction complex and recruitment of AXIN to the membrane;VEGFR2 mediated vascular permeability;FOXO-mediated transcription of cell cycle genes
865	CBFB	False	True	RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs);Transcriptional regulation by RUNX2;Transcriptional regulation by RUNX2;RUNX1 regulates estrogen receptor mediated transcription;Regulation of RUNX1 Expression and Activity;RUNX1 regulates expression of components of tight junctions;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;RUNX1 regulates transcription of genes involved in differentiation of HSCs;RUNX1 regulates transcription of genes involved in differentiation of HSCs;RUNX1 regulates transcription of genes involved in differentiation of keratinocytes;RUNX1 regulates transcription of genes involved in differentiation of keratinocytes;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known;RUNX1 regulates transcription of genes involved in BCR signaling;RUNX1 regulates transcription of genes involved in differentiation of myeloid cells;RUNX1 regulates transcription of genes involved in interleukin signaling;RUNX1 regulates transcription of genes involved in WNT signaling;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;RUNX2 regulates osteoblast differentiation;RUNX2 regulates osteoblast differentiation;RUNX2 regulates chondrocyte maturation;RUNX2 regulates bone development;RUNX2 regulates genes involved in cell migration;RUNX2 regulates genes involved in cell migration;RUNX2 regulates genes involved in differentiation of myeloid cells;Regulation of RUNX3 expression and activity;RUNX3 Regulates Immune Response and Cell Migration;RUNX3 Regulates Immune Response and Cell Migration;RUNX3 regulates RUNX1-mediated transcription;RUNX3 regulates p14-ARF;Estrogen-dependent gene expression
867	CBL	False	True	Interleukin-6 signaling;Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants;Spry regulation of FGF signaling;Regulation of KIT signaling;EGFR downregulation;TGF-beta receptor signaling activates SMADs;Constitutive Signaling by EGFRvIII;Negative regulation of FGFR1 signaling;Negative regulation of FGFR2 signaling;Negative regulation of FGFR3 signaling;Negative regulation of FGFR4 signaling;Negative regulation of MET activity;PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;InlB-mediated entry of Listeria monocytogenes into host cell;InlB-mediated entry of Listeria monocytogenes into host cell;Regulation of signaling by CBL;Regulation of signaling by CBL
871	SERPINH1	False	True	Collagen biosynthesis and modifying enzymes
875	CBS	False	True	Cysteine formation from homocysteine;Metabolism of ingested SeMet, Sec, MeSec into H2Se
890	CCNA2	False	True	Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1;G0 and Early G1;Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Regulation of APC/C activators between G1/S and early anaphase;SCF(Skp2)-mediated degradation of p27/p21;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;Ub-specific processing proteases;Processing of DNA double-strand break ends;TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest;Regulation of TP53 Activity through Phosphorylation;Regulation of TP53 Degradation;G2 Phase;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Cyclin A/B1/B2 associated events during G2/M transition;Cyclin A/B1/B2 associated events during G2/M transition;p53-Dependent G1 DNA Damage Response;Cyclin A:Cdk2-associated events at S phase entry
891	CCNB1	False	True	E2F-enabled inhibition of pre-replication complex formation;Polo-like kinase mediated events;Golgi Cisternae Pericentriolar Stack Reorganization;APC/C:Cdc20 mediated degradation of Cyclin B;Regulation of APC/C activators between G1/S and early anaphase;Phosphorylation of the APC/C;Phosphorylation of Emi1;Condensation of Prophase Chromosomes;MASTL Facilitates Mitotic Progression;Resolution of Sister Chromatid Cohesion;Condensation of Prometaphase Chromosomes;Regulation of PLK1 Activity at G2/M Transition;Activation of NIMA Kinases NEK9, NEK6, NEK7;Nuclear Pore Complex (NPC) Disassembly;Depolymerisation of the Nuclear Lamina;TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest;Mitotic Prophase;Cyclin A/B1/B2 associated events during G2/M transition;G2/M DNA replication checkpoint;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;The role of GTSE1 in G2/M progression after G2 checkpoint;Transcriptional regulation by RUNX2
892	CCNC	False	True	PPARA activates gene expression;NOTCH1 Intracellular Domain Regulates Transcription;Generic Transcription Pathway;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Transcriptional regulation of white adipocyte differentiation;Transcriptional regulation of white adipocyte differentiation
900	CCNG1	False	True	Regulation of TP53 Degradation
908	CCT6A	False	True	Prefoldin mediated transfer of substrate  to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Folding of actin by CCT/TriC;Association of TriC/CCT with target proteins during biosynthesis;Association of TriC/CCT with target proteins during biosynthesis;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
919	CD247	False	True	Nef and signal transduction;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Downstream TCR signaling;Phosphorylation of CD3 and TCR zeta chains;Translocation of ZAP-70 to Immunological synapse;Generation of second messenger molecules;FCGR activation;FCGR activation;Regulation of actin dynamics for phagocytic cup formation;Role of phospholipids in phagocytosis;PD-1 signaling
929	CD14	False	True	ER-Phagosome pathway;Caspase activation via Death Receptors in the presence of ligand;Toll Like Receptor 4 (TLR4) Cascade;Transfer of LPS from LBP carrier to CD14;MyD88:MAL(TIRAP) cascade initiated on plasma membrane;MyD88-independent TLR4 cascade ;Toll Like Receptor TLR1:TLR2 Cascade;Toll Like Receptor TLR6:TLR2 Cascade;TRIF-mediated programmed cell death;MyD88 deficiency (TLR2/4);IRAK4 deficiency (TLR2/4);Regulation of TLR by endogenous ligand;Neutrophil degranulation;Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon;IKK complex recruitment mediated by RIP1;TRAF6-mediated induction of TAK1 complex within TLR4 complex;IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
931	MS4A1	False	True	NA
950	SCARB2	False	True	Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis
956	ENTPD3	False	True	Phosphate bond hydrolysis by NTPDase proteins
960	CD44	False	True	Degradation of the extracellular matrix;Cell surface interactions at the vascular wall;Integrin cell surface interactions;Hyaluronan uptake and degradation;Neutrophil degranulation;Interferon gamma signaling
971	CD72	False	True	Other semaphorin interactions
975	CD81	False	True	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of Complement cascade
983	CDK1	False	True	MAPK3 (ERK1) activation;E2F-enabled inhibition of pre-replication complex formation;Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1;Golgi Cisternae Pericentriolar Stack Reorganization;Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes;APC/C:Cdc20 mediated degradation of Cyclin B;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Regulation of APC/C activators between G1/S and early anaphase;Phosphorylation of the APC/C;Phosphorylation of Emi1;Condensation of Prophase Chromosomes;MASTL Facilitates Mitotic Progression;Resolution of Sister Chromatid Cohesion;Condensation of Prometaphase Chromosomes;Regulation of PLK1 Activity at G2/M Transition;Activation of NIMA Kinases NEK9, NEK6, NEK7;Nuclear Pore Complex (NPC) Disassembly;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Depolymerisation of the Nuclear Lamina;Activation of E2F1 target genes at G1/S;Anchoring of the basal body to the plasma membrane;MAPK6/MAPK4 signaling;Ovarian tumor domain proteases;TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest;Regulation of TP53 Degradation;Mitotic Prophase;Cyclin A/B1/B2 associated events during G2/M transition;Cyclin A/B1/B2 associated events during G2/M transition;G2/M DNA replication checkpoint;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;The role of GTSE1 in G2/M progression after G2 checkpoint;AURKA Activation by TPX2;Transcriptional regulation by RUNX2
984	CDK11B	False	True	Recruitment of mitotic centrosome proteins and complexes
988	CDC5L	False	True	mRNA Splicing - Major Pathway
989	SEPT7	False	True	MAPK6/MAPK4 signaling
990	CDC6	False	True	Transcription of E2F targets under negative control by DREAM complex;Activation of ATR in response to replication stress;Activation of E2F1 target genes at G1/S;CDC6 association with the ORC:origin complex;CDT1 association with the CDC6:ORC:origin complex;Assembly of the pre-replicative complex;Orc1 removal from chromatin;Activation of the pre-replicative complex;CDK-mediated phosphorylation and removal of Cdc6
993	CDC25A	False	True	Transcription of E2F targets under negative control by DREAM complex;Polo-like kinase mediated events;Activation of ATR in response to replication stress;Ub-specific processing proteases;Cyclin E associated events during G1/S transition ;Cyclin A/B1/B2 associated events during G2/M transition;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Cyclin A:Cdk2-associated events at S phase entry;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
994	CDC25B	False	True	Cyclin A/B1/B2 associated events during G2/M transition;Cyclin A:Cdk2-associated events at S phase entry;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
995	CDC25C	False	True	Polo-like kinase mediated events;Activation of ATR in response to replication stress;RHO GTPases activate PKNs;TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest;TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain;Cyclin A/B1/B2 associated events during G2/M transition;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
998	CDC42	False	True	GPVI-mediated activation cascade;EGFR downregulation;Rho GTPase cycle;Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;CDO in myogenesis;CDO in myogenesis;CD28 dependent Vav1 pathway;EPHB-mediated forward signaling;EPHB-mediated forward signaling;DCC mediated attractive signaling;Inactivation of CDC42 and RAC1;VEGFA-VEGFR2 Pathway;RHO GTPases activate KTN1;RHO GTPases activate IQGAPs;RHO GTPases activate PAKs;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate Formins;RHO GTPases Activate Formins;MAPK6/MAPK4 signaling;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation;G beta:gamma signalling through CDC42;Factors involved in megakaryocyte development and platelet production
999	CDH1	False	True	Degradation of the extracellular matrix;Degradation of the extracellular matrix;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Integrin cell surface interactions;Apoptotic cleavage of cell adhesion  proteins;Adherens junctions interactions;RHO GTPases activate IQGAPs;InlA-mediated entry of Listeria monocytogenes into host cells
1003	CDH5	False	True	Adherens junctions interactions;VEGFR2 mediated vascular permeability
1017	CDK2	False	True	G0 and Early G1;Activation of ATR in response to replication stress;Regulation of APC/C activators between G1/S and early anaphase;SCF(Skp2)-mediated degradation of p27/p21;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;Processing of DNA double-strand break ends;TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest;Regulation of TP53 Activity through Phosphorylation;Regulation of TP53 Degradation;G2 Phase;Orc1 removal from chromatin;Activation of the pre-replicative complex;CDK-mediated phosphorylation and removal of Cdc6;Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes;Cyclin E associated events during G1/S transition ;Cyclin A/B1/B2 associated events during G2/M transition;p53-Dependent G1 DNA Damage Response;Cyclin A:Cdk2-associated events at S phase entry;PTK6 Regulates Cell Cycle;Meiotic recombination;Factors involved in megakaryocyte development and platelet production
1018	CDK3	False	True	NA
1019	CDK4	False	True	SCF(Skp2)-mediated degradation of p27/p21;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);Oncogene Induced Senescence;RMTs methylate histone arginines;Transcriptional regulation of white adipocyte differentiation;Ubiquitin-dependent degradation of Cyclin D1;Ubiquitin-dependent degradation of Cyclin D1;Cyclin D associated events in G1;PTK6 Regulates Cell Cycle;Transcriptional regulation by RUNX2;Meiotic recombination
1021	CDK6	False	True	Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);Oncogene Induced Senescence;Cyclin D associated events in G1;Regulation of RUNX1 Expression and Activity
1022	CDK7	False	True	Formation of RNA Pol II elongation complex ;Formation of the Early Elongation Complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of the HIV-1 Early Elongation Complex;RNA Pol II CTD phosphorylation and interaction with CE during HIV infection;HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;Formation of HIV-1 elongation complex containing HIV-1 Tat;Tat-mediated elongation of the HIV-1 transcript;NoRC negatively regulates rRNA expression;Formation of Incision Complex in GG-NER;RNA Polymerase II Pre-transcription Events;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;TP53 Regulates Transcription of DNA Repair Genes;RNA polymerase II transcribes snRNA genes;RNA polymerase II transcribes snRNA genes;Cyclin E associated events during G1/S transition ;Cyclin D associated events in G1;Cyclin A/B1/B2 associated events during G2/M transition;Cyclin A:Cdk2-associated events at S phase entry;mRNA Capping;RNA Polymerase I Transcription Initiation;RNA Polymerase I Promoter Escape;RNA Polymerase II Promoter Escape;RNA Polymerase I Chain Elongation;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase I Transcription Termination;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Elongation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Pol II CTD phosphorylation and interaction with CE;RUNX1 regulates transcription of genes involved in differentiation of HSCs
1025	CDK9	False	True	Formation of RNA Pol II elongation complex ;Formation of HIV elongation complex in the absence of HIV Tat;Formation of HIV-1 elongation complex containing HIV-1 Tat;Formation of HIV-1 elongation complex containing HIV-1 Tat;Pausing and recovery of Tat-mediated HIV elongation;Tat-mediated HIV elongation arrest and recovery;Tat-mediated elongation of the HIV-1 transcript;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;Interactions of Tat with host cellular proteins;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;RNA Polymerase II Pre-transcription Events;TP53 Regulates Transcription of DNA Repair Genes;RNA polymerase II transcribes snRNA genes;RNA polymerase II transcribes snRNA genes;RNA Polymerase II Transcription Elongation;Estrogen-dependent gene expression
1026	CDKN1A	False	True	SCF(Skp2)-mediated degradation of p27/p21;AKT phosphorylates targets in the cytosol;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;Constitutive Signaling by AKT1 E17K in Cancer;Interleukin-4 and Interleukin-13 signaling;TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest;Cyclin E associated events during G1/S transition ;Cyclin D associated events in G1;p53-Dependent G1 DNA Damage Response;Cyclin A:Cdk2-associated events at S phase entry;Transcriptional  activation of  cell cycle inhibitor p21 ;The role of GTSE1 in G2/M progression after G2 checkpoint;TFAP2 (AP-2) family regulates transcription of cell cycle factors;Transcriptional regulation by RUNX2;RUNX3 regulates CDKN1A transcription;FOXO-mediated transcription of cell cycle genes
1027	CDKN1B	False	True	SCF(Skp2)-mediated degradation of p27/p21;AKT phosphorylates targets in the cytosol;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;RHO GTPases activate CIT;Constitutive Signaling by AKT1 E17K in Cancer;TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest;Cyclin E associated events during G1/S transition ;Cyclin D associated events in G1;p53-Dependent G1 DNA Damage Response;Cyclin A:Cdk2-associated events at S phase entry;PTK6 Regulates Cell Cycle;FOXO-mediated transcription of cell cycle genes
1029	CDKN2A	False	True	Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);Oncogene Induced Senescence;SUMOylation of DNA damage response and repair proteins;SUMOylation of transcription factors;Regulation of TP53 Degradation;Cyclin D associated events in G1;Stabilization of p53;Regulation of RUNX3 expression and activity
1039	CDR2	False	True	NA
1043	NA	False	True	Post-translational modification: synthesis of GPI-anchored proteins
1053	CEBPE	False	True	NA
1062	CENPE	False	True	Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;COPI-dependent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;Kinesins
1070	CETN3	False	True	NA
1072	CFL1	False	True	Platelet degranulation ;Regulation of actin dynamics for phagocytic cup formation;EPHB-mediated forward signaling;Sema3A PAK dependent Axon repulsion;RHO GTPases Activate ROCKs;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
1073	CFL2	False	True	NA
1075	CTSC	False	True	COPII-mediated vesicle transport;MHC class II antigen presentation;Cargo concentration in the ER;Neutrophil degranulation
1080	CFTR	False	True	ABC-family proteins mediated transport;RHO GTPases regulate CFTR trafficking;Defective CFTR causes cystic fibrosis;Ub-specific processing proteases;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis
1102	RCBTB2	False	True	NA
1104	RCC1	False	True	Rev-mediated nuclear export of HIV RNA;Nuclear import of Rev protein
1107	CHD3	False	True	HDACs deacetylate histones;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;SUMOylation of chromatin organization proteins;Regulation of TP53 Activity through Acetylation;RNA Polymerase I Transcription Initiation;Regulation of PTEN gene transcription;Regulation of PTEN gene transcription
1111	CHEK1	False	True	Signaling by SCF-KIT;Activation of ATR in response to replication stress;Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;TP53 Regulates Transcription of DNA Repair Genes;Regulation of TP53 Activity through Phosphorylation;G2/M DNA damage checkpoint;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;Transcriptional Regulation by E2F6
1120	NA	False	True	Synthesis of PC;Synthesis of PE
1130	LYST	False	True	NA
1147	CHUK	False	True	Activation of NF-kappaB in B cells;Activation of NF-kappaB in B cells;ER-Phagosome pathway;NOD1/2 Signaling Pathway;TICAM1, RIP1-mediated IKK complex recruitment ;RIP-mediated NFkB activation via ZBP1;AKT phosphorylates targets in the cytosol;Downstream TCR signaling;FCERI mediated NF-kB activation;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;IKBKB deficiency causes SCID;IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR);IkBA variant leads to EDA-ID;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Constitutive Signaling by AKT1 E17K in Cancer;NIK-->noncanonical NF-kB signaling;MAP3K8 (TPL2)-dependent MAPK1/3 activation;Interleukin-1 signaling;TRAF6 mediated NF-kB activation;NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10;IRAK1 recruits IKK complex;IKK complex recruitment mediated by RIP1;IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
1152	CKB	False	True	Creatine metabolism
1155	TBCB	False	True	Post-chaperonin tubulin folding pathway
1159	CKMT1B	False	True	Creatine metabolism
1160	CKMT2	False	True	Creatine metabolism
1173	AP2M1	False	True	Nef mediated downregulation of CD28 cell surface expression;Nef Mediated CD4 Down-regulation;Retrograde neurotrophin signalling;Retrograde neurotrophin signalling;Nef Mediated CD8 Down-regulation;Gap junction degradation;Formation of annular gap junctions;MHC class II antigen presentation;EPH-ephrin mediated repulsion of cells;Trafficking of GluR2-containing AMPA receptors;Recycling pathway of L1;Recycling pathway of L1;WNT5A-dependent internalization of FZD4;WNT5A-dependent internalization of FZD2, FZD5 and ROR2;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;VLDLR internalisation and degradation;LDL clearance
1182	CLCN3	False	True	Stimuli-sensing channels
1186	NA	False	True	Stimuli-sensing channels
1196	CLK2	False	True	NA
1198	CLK3	False	True	NA
1207	CLNS1A	False	True	snRNP Assembly
1211	CLTA	False	True	Entry of Influenza Virion into Host Cell via Endocytosis;Retrograde neurotrophin signalling;Retrograde neurotrophin signalling;Gap junction degradation;Formation of annular gap junctions;MHC class II antigen presentation;EPH-ephrin mediated repulsion of cells;Lysosome Vesicle Biogenesis;Golgi Associated Vesicle Biogenesis;Recycling pathway of L1;Recycling pathway of L1;WNT5A-dependent internalization of FZD4;WNT5A-dependent internalization of FZD2, FZD5 and ROR2;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;VLDLR internalisation and degradation;LDL clearance
1212	CLTB	False	True	Gap junction degradation;Formation of annular gap junctions;EPH-ephrin mediated repulsion of cells;Lysosome Vesicle Biogenesis;WNT5A-dependent internalization of FZD4;WNT5A-dependent internalization of FZD2, FZD5 and ROR2;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis
1213	CLTC	False	True	Entry of Influenza Virion into Host Cell via Endocytosis;Retrograde neurotrophin signalling;Retrograde neurotrophin signalling;Gap junction degradation;Formation of annular gap junctions;MHC class II antigen presentation;EPH-ephrin mediated repulsion of cells;Lysosome Vesicle Biogenesis;Golgi Associated Vesicle Biogenesis;Recycling pathway of L1;Recycling pathway of L1;WNT5A-dependent internalization of FZD4;WNT5A-dependent internalization of FZD2, FZD5 and ROR2;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;VLDLR internalisation and degradation;LDL clearance
1244	ABCC2	False	True	ABC-family proteins mediated transport;Defective ABCC2 causes Dubin-Johnson syndrome
1277	COL1A1	False	True	GPVI-mediated activation cascade;Collagen degradation;Collagen degradation;Extracellular matrix organization;Collagen biosynthesis and modifying enzymes;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Assembly of collagen fibrils and other multimeric structures;Cell surface interactions at the vascular wall;Integrin cell surface interactions;Integrin cell surface interactions;Anchoring fibril formation;Crosslinking of collagen fibrils;Syndecan interactions;Non-integrin membrane-ECM interactions;ECM proteoglycans;ECM proteoglycans;Scavenging by Class A Receptors;GP1b-IX-V activation signalling;Platelet Adhesion to exposed collagen;Platelet Adhesion to exposed collagen;Platelet Aggregation (Plug Formation);MET activates PTK2 signaling;RUNX2 regulates osteoblast differentiation;Collagen chain trimerization
1278	COL1A2	False	True	GPVI-mediated activation cascade;Collagen degradation;Collagen degradation;Extracellular matrix organization;Collagen biosynthesis and modifying enzymes;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Assembly of collagen fibrils and other multimeric structures;Cell surface interactions at the vascular wall;Integrin cell surface interactions;Integrin cell surface interactions;Anchoring fibril formation;Crosslinking of collagen fibrils;Syndecan interactions;Non-integrin membrane-ECM interactions;ECM proteoglycans;ECM proteoglycans;Scavenging by Class A Receptors;GP1b-IX-V activation signalling;Interleukin-4 and Interleukin-13 signaling;Platelet Adhesion to exposed collagen;Platelet Adhesion to exposed collagen;Platelet Aggregation (Plug Formation);MET activates PTK2 signaling;Collagen chain trimerization
1296	COL8A2	False	True	Collagen degradation;Collagen degradation;Collagen biosynthesis and modifying enzymes;Assembly of collagen fibrils and other multimeric structures;Integrin cell surface interactions;Collagen chain trimerization
1314	COPA	False	True	COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic
1315	COPB1	False	True	Neutrophil degranulation;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic
1326	MAP3K8	False	True	CD28 dependent PI3K/Akt signaling;MAP3K8 (TPL2)-dependent MAPK1/3 activation;MAP3K8 (TPL2)-dependent MAPK1/3 activation
1345	COX6C	False	True	TP53 Regulates Metabolic Genes;Respiratory electron transport
1368	CPM	False	True	Post-translational modification: synthesis of GPI-anchored proteins
1373	CPS1	False	True	Urea cycle
1374	CPT1A	False	True	RORA activates gene expression;PPARA activates gene expression;Import of palmitoyl-CoA into the mitochondrial matrix;Signaling by Retinoic Acid
1387	CREBBP	False	True	Regulation of gene expression by Hypoxia-inducible Factor;RORA activates gene expression;BMAL1:CLOCK,NPAS2 activates circadian gene expression;Pre-NOTCH Transcription and Translation;Pre-NOTCH Transcription and Translation;PPARA activates gene expression;PPARA activates gene expression;Formation of the beta-catenin:TCF transactivating complex;Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells;NOTCH1 Intracellular Domain Regulates Transcription;NOTCH1 Intracellular Domain Regulates Transcription;Transcriptional activation of mitochondrial biogenesis;Activation of gene expression by SREBF (SREBP);Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production;HATs acetylate histones;Attenuation phase;Notch-HLH transcription pathway;Transcriptional regulation of white adipocyte differentiation;Transcriptional regulation of white adipocyte differentiation;SUMOylation of transcription cofactors;Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha);Circadian Clock;Activation of anterior HOX genes in hindbrain development during early embryogenesis;CD209 (DC-SIGN) signaling;TP53 Regulates Transcription of Genes Involved in Cytochrome C Release;Activation of the TFAP2 (AP-2) family of transcription factors;RUNX1 regulates transcription of genes involved in differentiation of myeloid cells;RUNX3 regulates NOTCH signaling;RUNX3 regulates NOTCH signaling;NOTCH3 Intracellular Domain Regulates Transcription;NOTCH3 Intracellular Domain Regulates Transcription;NOTCH4 Intracellular Domain Regulates Transcription;Estrogen-dependent gene expression;TRAF3-dependent IRF activation pathway;TRAF6 mediated IRF7 activation;FOXO-mediated transcription of cell death genes;Regulation of FOXO transcriptional activity by acetylation;Regulation of FOXO transcriptional activity by acetylation
1396	CRIP1	False	True	NA
1398	CRK	False	True	ARMS-mediated activation;ARMS-mediated activation;Downstream signal transduction;Regulation of actin dynamics for phagocytic cup formation;p130Cas linkage to MAPK signaling for integrins;VEGFA-VEGFR2 Pathway;PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases;MET activates RAP1 and RAC1;MET receptor recycling;Regulation of signaling by CBL
1399	CRKL	False	True	Frs2-mediated activation;Frs2-mediated activation;Downstream signal transduction;MET activates RAP1 and RAC1;MET receptor recycling;Erythropoietin activates RAS;Erythropoietin activates RAS;Regulation of signaling by CBL
1408	CRY2	False	True	Circadian Clock
1409	CRYAA	False	True	NA
1410	CRYAB	False	True	HSF1-dependent transactivation
1415	CRYBB2	False	True	NA
1429	CRYZ	False	True	NA
1431	CS	False	True	Mitochondrial protein import;Citric acid cycle (TCA cycle)
1432	MAPK14	False	True	NOD1/2 Signaling Pathway;p38MAPK events;p38MAPK events;ERK/MAPK targets;Activation of PPARGC1A (PGC-1alpha) by phosphorylation;Oxidative Stress Induced Senescence;CDO in myogenesis;CDO in myogenesis;DSCAM interactions;ADP signalling through P2Y purinoceptor 1;Platelet sensitization by LDL;VEGFA-VEGFR2 Pathway;activated TAK1 mediates p38 MAPK activation;Activation of the AP-1 family of transcription factors;KSRP (KHSRP) binds and destabilizes mRNA;RHO GTPases Activate NADPH Oxidases;Neutrophil degranulation;Regulation of TP53 Activity through Phosphorylation
1434	CSE1L	False	True	NA
1436	CSF1R	False	True	Other interleukin signaling
1452	CSNK1A1	False	True	Degradation of beta-catenin by the destruction complex;Beta-catenin phosphorylation cascade;Disassembly of the destruction complex and recruitment of AXIN to the membrane;Disassembly of the destruction complex and recruitment of AXIN to the membrane;Misspliced GSK3beta mutants stabilize beta-catenin;S33 mutants of beta-catenin aren't phosphorylated;S37 mutants of beta-catenin aren't phosphorylated;S45 mutants of beta-catenin aren't phosphorylated;T41 mutants of beta-catenin aren't phosphorylated;APC truncation mutants have impaired AXIN binding;AXIN missense mutants destabilize the destruction complex;Truncations of AMER1 destabilize the destruction complex;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Activation of SMO;Activation of SMO
1453	CSNK1D	False	True	COPII-mediated vesicle transport;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Circadian Clock;Anchoring of the basal body to the plasma membrane;Major pathway of rRNA processing in the nucleolus and cytosol;AURKA Activation by TPX2
1457	CSNK2A1	False	True	Synthesis of PC;WNT mediated activation of DVL;Condensation of Prometaphase Chromosomes;Signal transduction by L1;Regulation of TP53 Activity through Phosphorylation;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding;Receptor Mediated Mitophagy;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known;Regulation of PTEN stability and activity
1459	CSNK2A2	False	True	Synthesis of PC;WNT mediated activation of DVL;Condensation of Prometaphase Chromosomes;Signal transduction by L1;Regulation of TP53 Activity through Phosphorylation;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding;Receptor Mediated Mitophagy;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known;Regulation of PTEN stability and activity
1465	CSRP1	False	True	MTF1 activates gene expression
1469	CST1	True	True	NA
1470	CST2	True	True	NA
1471	NA	False	True	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Neutrophil degranulation;Post-translational protein phosphorylation;Amyloid fiber formation
1472	CST4	True	True	NA
1474	NA	True	False	NA
1475	CSTA	True	True	Formation of the cornified envelope
1476	CSTB	True	True	Neutrophil degranulation
1479	CSTF3	False	True	Cleavage of Growing Transcript in the Termination Region ;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Processing of Intronless Pre-mRNAs
1487	CTBP1	False	True	Deactivation of the beta-catenin transactivating complex;SUMOylation of transcription cofactors;Repression of WNT target genes;TCF7L2 mutants don't bind CTBP
1488	CTBP2	False	True	Repression of WNT target genes;TCF7L2 mutants don't bind CTBP
1495	CTNNA1	False	True	CDO in myogenesis;CDO in myogenesis;Adherens junctions interactions;VEGFR2 mediated vascular permeability;RHO GTPases activate IQGAPs
1499	CTNNB1	False	True	Degradation of beta-catenin by the destruction complex;Beta-catenin phosphorylation cascade;TCF dependent signaling in response to WNT;Formation of the beta-catenin:TCF transactivating complex;Formation of the beta-catenin:TCF transactivating complex;LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production;Apoptotic cleavage of cell adhesion  proteins;CDO in myogenesis;CDO in myogenesis;Deactivation of the beta-catenin transactivating complex;Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1);Ca2+ pathway;Adherens junctions interactions;Binding of TCF/LEF:CTNNB1 to target gene promoters;Disassembly of the destruction complex and recruitment of AXIN to the membrane;Disassembly of the destruction complex and recruitment of AXIN to the membrane;VEGFR2 mediated vascular permeability;Misspliced GSK3beta mutants stabilize beta-catenin;S33 mutants of beta-catenin aren't phosphorylated;S37 mutants of beta-catenin aren't phosphorylated;S45 mutants of beta-catenin aren't phosphorylated;T41 mutants of beta-catenin aren't phosphorylated;RHO GTPases activate IQGAPs;InlA-mediated entry of Listeria monocytogenes into host cells;RUNX3 regulates WNT signaling
1500	CTNND1	False	True	Adherens junctions interactions;VEGFR2 mediated vascular permeability;InlA-mediated entry of Listeria monocytogenes into host cells
1503	CTPS1	False	True	Interconversion of nucleotide di- and triphosphates
1508	CTSB	True	True	Collagen degradation;Trafficking and processing of endosomal TLR;Assembly of collagen fibrils and other multimeric structures;MHC class II antigen presentation;Neutrophil degranulation
1509	CTSD	True	True	Collagen degradation;Metabolism of Angiotensinogen to Angiotensins;MHC class II antigen presentation;Neutrophil degranulation;Estrogen-dependent gene expression
1512	NA	False	True	MHC class II antigen presentation;Surfactant metabolism;Neutrophil degranulation
1513	CTSK	False	True	Collagen degradation;Degradation of the extracellular matrix;Activation of Matrix Metalloproteinases;Trafficking and processing of endosomal TLR;MHC class II antigen presentation;RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
1514	CTSL	False	True	Endosomal/Vacuolar pathway;Collagen degradation;Degradation of the extracellular matrix;Trafficking and processing of endosomal TLR;Assembly of collagen fibrils and other multimeric structures;MHC class II antigen presentation;RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
1515	CTSV	True	True	Endosomal/Vacuolar pathway;Degradation of the extracellular matrix;Activation of Matrix Metalloproteinases;Trafficking and processing of endosomal TLR;Assembly of collagen fibrils and other multimeric structures;MHC class II antigen presentation;RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
1520	NA	False	True	Endosomal/Vacuolar pathway;Degradation of the extracellular matrix;Degradation of the extracellular matrix;Trafficking and processing of endosomal TLR;Assembly of collagen fibrils and other multimeric structures;MHC class II antigen presentation;Neutrophil degranulation
1523	CUX1	False	True	Signaling by cytosolic FGFR1 fusion mutants;Signaling by FGFR1 in disease;Intra-Golgi traffic
1534	CYB561	False	True	NA
1537	CYC1	False	True	Mitochondrial protein import;Respiratory electron transport
1601	DAB2	False	True	Gap junction degradation;Formation of annular gap junctions;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis
1605	DAG1	False	True	Non-integrin membrane-ECM interactions;ECM proteoglycans;ECM proteoglycans;Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3;Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2;Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1;O-linked glycosylation;Regulation of expression of SLITs and ROBOs
1608	NA	False	True	Effects of PIP2 hydrolysis
1613	DAPK3	False	True	Caspase activation via Dependence Receptors in the absence of ligand
1615	DARS	False	True	SeMet incorporation into proteins;Cytosolic tRNA aminoacylation
1616	DAXX	False	True	SUMOylation of transcription cofactors;Regulation of TP53 Degradation
1622	DBI	False	True	Mitochondrial Fatty Acid Beta-Oxidation
1627	DBN1	False	True	NA
1630	DCC	False	True	Netrin-1 signaling;Netrin-1 signaling;DSCAM interactions;DCC mediated attractive signaling;DCC mediated attractive signaling;Netrin mediated repulsion signals;Caspase activation via Dependence Receptors in the absence of ligand;Role of second messengers in netrin-1 signaling;Regulation of commissural axon pathfinding by SLIT and ROBO
1632	ECI1	False	True	mitochondrial fatty acid beta-oxidation of unsaturated fatty acids
1636	ACE	False	True	Metabolism of Angiotensinogen to Angiotensins
1639	DCTN1	False	True	MHC class II antigen presentation;Regulation of PLK1 Activity at G2/M Transition;HSP90 chaperone cycle for steroid hormone receptors (SHR);Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;XBP1(S) activates chaperone genes;Anchoring of the basal body to the plasma membrane;COPI-mediated anterograde transport;COPI-independent Golgi-to-ER retrograde traffic;AURKA Activation by TPX2
1642	DDB1	False	True	Recognition of DNA damage by PCNA-containing replication complex;DNA Damage Recognition in GG-NER;Formation of Incision Complex in GG-NER;Dual Incision in GG-NER;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Neddylation
1643	DDB2	False	True	Ub-specific processing proteases;DNA Damage Recognition in GG-NER;Formation of Incision Complex in GG-NER;Dual Incision in GG-NER;TP53 Regulates Transcription of DNA Repair Genes;Neddylation
1646	AKR1C2	False	True	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol;Synthesis of bile acids and bile salts via 24-hydroxycholesterol;Synthesis of bile acids and bile salts via 27-hydroxycholesterol
1649	DDIT3	False	True	ATF4 activates genes;ATF6 (ATF6-alpha) activates chaperone genes;FOXO-mediated transcription of cell death genes;FOXO-mediated transcription of cell death genes
1650	DDOST	False	True	SRP-dependent cotranslational protein targeting to membrane;Asparagine N-linked glycosylation;Neutrophil degranulation;Advanced glycosylation endproduct receptor signaling
1653	DDX1	False	True	tRNA processing in the nucleus
1654	DDX3X	False	True	Neutrophil degranulation
1655	DDX5	False	True	SUMOylation of transcription cofactors;mRNA Splicing - Major Pathway;Estrogen-dependent gene expression
1659	DHX8	False	True	NA
1660	DHX9	False	True	RIP-mediated NFkB activation via ZBP1;DEx/H-box helicases activate type I IFN and inflammatory cytokines production ;mRNA Splicing - Major Pathway
1665	DHX15	False	True	mRNA Splicing - Major Pathway
1668	NA	True	False	Defensins;Alpha-defensins
1674	DES	False	True	Striated Muscle Contraction
1675	NA	False	True	Platelet degranulation ;Alternative complement activation;Neutrophil degranulation
1676	DFFA	False	True	Activation of DNA fragmentation factor
1727	CYB5R3	False	True	Vitamin C (ascorbate) metabolism;Phase I - Functionalization of compounds;Neutrophil degranulation
1736	DKC1	False	True	Telomere Extension By Telomerase;rRNA modification in the nucleus and cytosol
1737	DLAT	False	True	Regulation of pyruvate dehydrogenase (PDH) complex;Glyoxylate metabolism and glycine degradation;Signaling by Retinoic Acid;Pyruvate metabolism
1743	DLST	False	True	Glyoxylate metabolism and glycine degradation;Lysine catabolism;Citric acid cycle (TCA cycle)
1750	NA	False	True	Regulation of RUNX2 expression and activity
1755	DMBT1	True	True	Surfactant metabolism
1756	DMD	False	True	Non-integrin membrane-ECM interactions;Striated Muscle Contraction
1760	DMPK	False	True	Ion homeostasis
1778	DYNC1H1	False	True	Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;Regulation of PLK1 Activity at G2/M Transition;HSP90 chaperone cycle for steroid hormone receptors (SHR);Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;RHO GTPases Activate Formins;Neutrophil degranulation;COPI-mediated anterograde transport;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;AURKA Activation by TPX2
1785	DNM2	False	True	Toll Like Receptor 4 (TLR4) Cascade;Retrograde neurotrophin signalling;Gap junction degradation;Formation of annular gap junctions;NOSTRIN mediated eNOS trafficking;MHC class II antigen presentation;Lysosome Vesicle Biogenesis;Golgi Associated Vesicle Biogenesis;Recycling pathway of L1;Clathrin-mediated endocytosis
1801	DPH1	False	True	Synthesis of diphthamide-EEF2
1806	DPYD	False	True	Pyrimidine catabolism
1808	DPYSL2	False	True	CRMPs in Sema3A signaling;Recycling pathway of L1
1823	DSC1	False	True	Neutrophil degranulation;Keratinization;Formation of the cornified envelope
1825	DSC3	True	True	Keratinization;Formation of the cornified envelope
1828	DSG1	True	True	Apoptotic cleavage of cell adhesion  proteins;Neutrophil degranulation;Keratinization;Formation of the cornified envelope
1829	DSG2	False	True	Apoptotic cleavage of cell adhesion  proteins;Keratinization;Formation of the cornified envelope
1832	DSP	True	True	Apoptotic cleavage of cell adhesion  proteins;Neutrophil degranulation;Keratinization;Formation of the cornified envelope
1838	DTNB	False	True	NA
1854	DUT	False	True	Interconversion of nucleotide di- and triphosphates
1857	DVL3	False	True	TCF dependent signaling in response to WNT;WNT mediated activation of DVL;PCP/CE pathway;PCP/CE pathway;Degradation of DVL;Disassembly of the destruction complex and recruitment of AXIN to the membrane;Disassembly of the destruction complex and recruitment of AXIN to the membrane;Negative regulation of TCF-dependent signaling by DVL-interacting proteins;RHO GTPases Activate Formins
1859	DYRK1A	False	True	G0 and Early G1
1861	TOR1A	False	True	Cargo recognition for clathrin-mediated endocytosis
1874	E2F4	False	True	Transcription of E2F targets under negative control by DREAM complex;Transcription of E2F targets under negative control by DREAM complex;Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1;G0 and Early G1;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;Activation of E2F1 target genes at G1/S;Activation of E2F1 target genes at G1/S;TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest;Cyclin E associated events during G1/S transition ;Cyclin D associated events in G1;Cyclin A:Cdk2-associated events at S phase entry
1890	TYMP	True	True	Pyrimidine salvage;Pyrimidine catabolism
1891	ECH1	False	True	Peroxisomal protein import;Peroxisomal protein import
1892	ECHS1	False	True	Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA;Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA;Beta oxidation of octanoyl-CoA to hexanoyl-CoA;Beta oxidation of hexanoyl-CoA to butanoyl-CoA;Beta oxidation of butanoyl-CoA to acetyl-CoA
1902	LPAR1	False	True	G alpha (q) signalling events;G alpha (i) signalling events;Lysosphingolipid and LPA receptors
1915	EEF1A1	False	True	Eukaryotic Translation Elongation;Eukaryotic Translation Elongation;Peptide chain elongation;HSF1 activation;Neutrophil degranulation;Protein methylation
1917	EEF1A2	False	True	Eukaryotic Translation Elongation
1933	EEF1B2	False	True	Eukaryotic Translation Elongation
1936	EEF1D	False	True	Eukaryotic Translation Elongation
1937	EEF1G	True	True	Eukaryotic Translation Elongation
1938	EEF2	True	True	Peptide chain elongation;Peptide chain elongation;Uptake and function of diphtheria toxin;Synthesis of diphthamide-EEF2;Synthesis of diphthamide-EEF2;Neutrophil degranulation;Protein methylation
1956	EGFR	False	True	Signaling by ERBB2;Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants;Signaling by ERBB4;SHC1 events in ERBB2 signaling;SHC1 events in ERBB2 signaling;PLCG1 events in ERBB2 signaling;PIP3 activates AKT signaling;Signaling by EGFR;GRB2 events in EGFR signaling;GAB1 signalosome;SHC1 events in EGFR signaling;EGFR downregulation;GRB2 events in ERBB2 signaling;PI3K events in ERBB2 signaling;EGFR interacts with phospholipase C-gamma;EGFR Transactivation by Gastrin;Constitutive Signaling by Aberrant PI3K in Cancer;Signal transduction by L1;Constitutive Signaling by EGFRvIII;Inhibition of Signaling by Overexpressed EGFR;RAF/MAP kinase cascade;ERBB2 Regulates Cell Motility;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;ERBB2 Activates PTK6 Signaling;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;PTK6 promotes HIF1A stabilization;Downregulation of ERBB2 signaling;TFAP2 (AP-2) family regulates transcription of growth factors and their receptors;NOTCH3 Activation and Transmission of Signal to the Nucleus
1958	EGR1	False	True	Regulation of PTEN gene transcription;Regulation of PTEN gene transcription;Interferon alpha/beta signaling
1962	EHHADH	False	True	Beta-oxidation of very long chain fatty acids;Peroxisomal protein import;Peroxisomal protein import
1964	EIF1AX	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit
1965	EIF2S1	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;PERK regulates gene expression;ABC-family proteins mediated transport;Translation initiation complex formation;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Recycling of eIF2:GDP
1967	EIF2B1	False	True	Recycling of eIF2:GDP
1969	EPHA2	False	True	EPH-Ephrin signaling;EPH-Ephrin signaling;EPHA-mediated growth cone collapse;EPHA-mediated growth cone collapse;EPH-ephrin mediated repulsion of cells;EPH-ephrin mediated repulsion of cells
1973	EIF4A1	True	True	ISG15 antiviral mechanism;L13a-mediated translational silencing of Ceruloplasmin expression;Deadenylation of mRNA;Translation initiation complex formation;Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit
1974	EIF4A2	False	True	ISG15 antiviral mechanism;L13a-mediated translational silencing of Ceruloplasmin expression;Deadenylation of mRNA;Translation initiation complex formation;Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit
1975	EIF4B	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;mTORC1-mediated signalling;Deadenylation of mRNA;Translation initiation complex formation;Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit
1977	EIF4E	False	True	ISG15 antiviral mechanism;L13a-mediated translational silencing of Ceruloplasmin expression;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;mTORC1-mediated signalling;Deadenylation of mRNA;Translation initiation complex formation;Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit
1978	EIF4EBP1	False	True	mTORC1-mediated signalling;Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
1979	EIF4EBP2	False	True	NA
1981	EIF4G1	False	True	ISG15 antiviral mechanism;L13a-mediated translational silencing of Ceruloplasmin expression;mTORC1-mediated signalling;Deadenylation of mRNA;AUF1 (hnRNP D0) binds and destabilizes mRNA;Translation initiation complex formation;Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
1982	EIF4G2	False	True	ISG15 antiviral mechanism
1983	EIF5	False	True	Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit
1984	EIF5A	False	True	Hypusine synthesis from eIF5A-lysine
1992	SERPINB1	True	True	Neutrophil degranulation
1994	ELAVL1	False	True	HuR (ELAVL1) binds and stabilizes mRNA;mRNA Splicing - Major Pathway
2001	ELF5	False	True	NA
2010	EMD	False	True	Clearance of Nuclear Envelope Membranes from Chromatin;Initiation of Nuclear Envelope Reformation;Depolymerisation of the Nuclear Lamina
2011	MARK2	False	True	NA
2017	CTTN	False	True	RHO GTPases activate PAKs;Clathrin-mediated endocytosis
2021	ENDOG	False	True	NA
2023	ENO1	True	True	Glycolysis;Gluconeogenesis
2026	ENO2	False	True	Glycolysis;Gluconeogenesis
2027	ENO3	False	True	Glycolysis;Gluconeogenesis
2033	EP300	False	True	Regulation of gene expression by Hypoxia-inducible Factor;RORA activates gene expression;RORA activates gene expression;Polo-like kinase mediated events;Pre-NOTCH Transcription and Translation;Pre-NOTCH Transcription and Translation;PPARA activates gene expression;Formation of the beta-catenin:TCF transactivating complex;Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells;NOTCH1 Intracellular Domain Regulates Transcription;NOTCH1 Intracellular Domain Regulates Transcription;NOTCH2 intracellular domain regulates transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production;HATs acetylate histones;Attenuation phase;Transcriptional regulation of white adipocyte differentiation;Transcriptional regulation of white adipocyte differentiation;SUMOylation of transcription cofactors;Circadian Clock;Circadian Clock;B-WICH complex positively regulates rRNA expression;Activation of anterior HOX genes in hindbrain development during early embryogenesis;CD209 (DC-SIGN) signaling;Metalloprotease DUBs;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest;Regulation of TP53 Activity through Acetylation;Regulation of TP53 Activity through Methylation;PI5P Regulates TP53 Acetylation;Activation of the TFAP2 (AP-2) family of transcription factors;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known;RUNX3 regulates NOTCH signaling;RUNX3 regulates NOTCH signaling;Regulation of RUNX3 expression and activity;RUNX3 regulates p14-ARF;NOTCH3 Intracellular Domain Regulates Transcription;NOTCH3 Intracellular Domain Regulates Transcription;NOTCH4 Intracellular Domain Regulates Transcription;Estrogen-dependent gene expression;TRAF3-dependent IRF activation pathway;TRAF6 mediated IRF7 activation;FOXO-mediated transcription of cell death genes;Regulation of FOXO transcriptional activity by acetylation;Regulation of FOXO transcriptional activity by acetylation
2034	EPAS1	False	True	Regulation of gene expression by Hypoxia-inducible Factor;Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Transcriptional regulation of pluripotent stem cells;PTK6 Expression;Neddylation
2036	EPB41L1	False	True	Trafficking of AMPA receptors;Neurexins and neuroligins
2037	EPB41L2	False	True	Neurexins and neuroligins
2040	STOM	False	True	Stimuli-sensing channels;Neutrophil degranulation
2041	EPHA1	False	True	EPH-Ephrin signaling;EPH-Ephrin signaling;POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation;EPHA-mediated growth cone collapse;EPHA-mediated growth cone collapse;EPH-ephrin mediated repulsion of cells;EPH-ephrin mediated repulsion of cells
2043	EPHA4	False	True	EPH-Ephrin signaling;EPH-Ephrin signaling;EPHA-mediated growth cone collapse;EPHA-mediated growth cone collapse;EPH-ephrin mediated repulsion of cells;EPH-ephrin mediated repulsion of cells
2047	EPHB1	False	True	EPH-Ephrin signaling;EPH-Ephrin signaling;EPHB-mediated forward signaling;EPHB-mediated forward signaling;Ephrin signaling;Ephrin signaling;EPH-ephrin mediated repulsion of cells
2051	EPHB6	False	True	EPH-Ephrin signaling;EPH-Ephrin signaling;EPHB-mediated forward signaling;EPHB-mediated forward signaling;Ephrin signaling;Ephrin signaling;EPH-ephrin mediated repulsion of cells
2054	STX2	False	True	NA
2058	EPRS	False	True	SeMet incorporation into proteins;Cytosolic tRNA aminoacylation;tRNA modification in the nucleus and cytosol
2060	EPS15	False	True	EGFR downregulation;Negative regulation of MET activity;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;InlB-mediated entry of Listeria monocytogenes into host cell
2064	ERBB2	False	True	Signaling by ERBB2;SHC1 events in ERBB2 signaling;SHC1 events in ERBB2 signaling;PLCG1 events in ERBB2 signaling;PIP3 activates AKT signaling;GRB7 events in ERBB2 signaling;Downregulation of ERBB2:ERBB3 signaling;GRB2 events in ERBB2 signaling;GRB2 events in ERBB2 signaling;PI3K events in ERBB2 signaling;Constitutive Signaling by Aberrant PI3K in Cancer;Sema4D induced cell migration and growth-cone collapse;RAF/MAP kinase cascade;ERBB2 Regulates Cell Motility;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;ERBB2 Activates PTK6 Signaling;Downregulation of ERBB2 signaling;TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
2065	ERBB3	False	True	Signaling by ERBB2;Signaling by ERBB4;SHC1 events in ERBB2 signaling;SHC1 events in ERBB2 signaling;PIP3 activates AKT signaling;GRB7 events in ERBB2 signaling;Downregulation of ERBB2:ERBB3 signaling;PI3K events in ERBB2 signaling;Constitutive Signaling by Aberrant PI3K in Cancer;RAF/MAP kinase cascade;ERBB2 Regulates Cell Motility;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;ERBB2 Activates PTK6 Signaling;Downregulation of ERBB2 signaling
2066	ERBB4	False	True	Signaling by ERBB2;Signaling by ERBB4;SHC1 events in ERBB2 signaling;SHC1 events in ERBB2 signaling;PI3K events in ERBB4 signaling;SHC1 events in ERBB4 signaling;Nuclear signaling by ERBB4;Nuclear signaling by ERBB4;Downregulation of ERBB4 signaling;PIP3 activates AKT signaling;GRB2 events in ERBB2 signaling;PI3K events in ERBB2 signaling;Constitutive Signaling by Aberrant PI3K in Cancer;RAF/MAP kinase cascade;ERBB2 Regulates Cell Motility;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;ERBB2 Activates PTK6 Signaling;Downregulation of ERBB2 signaling;Estrogen-dependent gene expression;Long-term potentiation
2073	ERCC5	False	True	Formation of Incision Complex in GG-NER;Dual Incision in GG-NER;Dual incision in TC-NER
2078	ERG	False	True	NA
2079	ERH	False	True	NA
2081	ERN1	False	True	IRE1alpha activates chaperones;IRE1alpha activates chaperones
2091	FBL	False	True	rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol
2098	ESD	False	True	Glutathione conjugation
2099	ESR1	False	True	Nuclear signaling by ERBB4;PIP3 activates AKT signaling;Constitutive Signaling by Aberrant PI3K in Cancer;Nuclear Receptor transcription pathway;SUMOylation of intracellular receptors;Ovarian tumor domain proteases;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;TFAP2 (AP-2) family regulates transcription of growth factors and their receptors;RUNX1 regulates estrogen receptor mediated transcription;ESR-mediated signaling;RUNX1 regulates transcription of genes involved in WNT signaling;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Estrogen-dependent gene expression
2103	ESRRB	False	True	Nuclear Receptor transcription pathway
2107	ETF1	False	True	Eukaryotic Translation Termination;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
2108	ETFA	False	True	Respiratory electron transport
2109	ETFB	False	True	Respiratory electron transport;Protein methylation
2125	EVPL	False	True	Formation of the cornified envelope
2130	EWSR1	False	True	NA
2147	F2	False	True	Intrinsic Pathway of Fibrin Clot Formation;Common Pathway of Fibrin Clot Formation;Gamma-carboxylation of protein precursors;Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus;Removal of aminoterminal propeptides from gamma-carboxylated proteins;Cell surface interactions at the vascular wall;Peptide ligand-binding receptors;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);G alpha (q) signalling events;Thrombin signalling through proteinase activated receptors (PARs);Platelet Aggregation (Plug Formation);Regulation of Complement cascade
2149	F2R	False	True	Common Pathway of Fibrin Clot Formation;Peptide ligand-binding receptors;G alpha (q) signalling events;Thrombin signalling through proteinase activated receptors (PARs);Thrombin signalling through proteinase activated receptors (PARs)
2150	F2RL1	False	True	Peptide ligand-binding receptors;G alpha (q) signalling events
2155	F7	False	True	BMAL1:CLOCK,NPAS2 activates circadian gene expression;Extrinsic Pathway of Fibrin Clot Formation;Gamma-carboxylation of protein precursors;Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus;Removal of aminoterminal propeptides from gamma-carboxylated proteins
2170	FABP3	False	True	Triglyceride catabolism
2171	FABP5	True	True	Triglyceride catabolism;Signaling by Retinoic Acid;Neutrophil degranulation
2173	FABP7	False	True	Triglyceride catabolism;NOTCH3 Intracellular Domain Regulates Transcription
2175	FANCA	False	True	Fanconi Anemia Pathway
2176	FANCC	False	True	Fanconi Anemia Pathway;TP53 Regulates Transcription of DNA Repair Genes
2177	FANCD2	False	True	Fanconi Anemia Pathway;TP53 Regulates Transcription of DNA Repair Genes
2184	FAH	False	True	Phenylalanine and tyrosine catabolism
2185	PTK2B	False	True	Signal regulatory protein family interactions;VEGFA-VEGFR2 Pathway;Interleukin-2 signaling
2187	FANCB	False	True	Fanconi Anemia Pathway
2189	FANCG	False	True	Fanconi Anemia Pathway
2193	FARSA	False	True	Cytosolic tRNA aminoacylation
2194	FASN	False	True	ChREBP activates metabolic gene expression;Vitamin B5 (pantothenate) metabolism;Activation of gene expression by SREBF (SREBP);Fatty acyl-CoA biosynthesis;Fatty acyl-CoA biosynthesis
2202	EFEMP1	False	True	Molecules associated with elastic fibres;Molecules associated with elastic fibres
2203	FBP1	False	True	Gluconeogenesis
2205	FCER1A	False	True	Fc epsilon receptor (FCERI) signaling;Fc epsilon receptor (FCERI) signaling;Role of LAT2/NTAL/LAB on calcium mobilization;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;FCERI mediated Ca+2 mobilization;FCERI mediated NF-kB activation
2207	FCER1G	False	True	GPVI-mediated activation cascade;Cell surface interactions at the vascular wall;Fc epsilon receptor (FCERI) signaling;Fc epsilon receptor (FCERI) signaling;Role of LAT2/NTAL/LAB on calcium mobilization;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;FCERI mediated Ca+2 mobilization;FCERI mediated NF-kB activation;Dectin-2 family;Dectin-2 family;Neutrophil degranulation;Platelet Adhesion to exposed collagen
2217	FCGRT	False	True	NA
2222	FDFT1	False	True	Cholesterol biosynthesis;PPARA activates gene expression;Activation of gene expression by SREBF (SREBP)
2224	FDPS	False	True	Cholesterol biosynthesis;Activation of gene expression by SREBF (SREBP)
2237	FEN1	False	True	POLB-Dependent Long Patch Base Excision Repair;Early Phase of HIV Life Cycle;Removal of the Flap Intermediate from the C-strand;PCNA-Dependent Long Patch Base Excision Repair;HDR through MMEJ (alt-NHEJ);Removal of the Flap Intermediate
2241	FER	False	True	Signaling by SCF-KIT
2242	FES	False	True	Signaling by SCF-KIT;Sema3A PAK dependent Axon repulsion;SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion;CRMPs in Sema3A signaling
2243	FGA	False	True	Platelet degranulation ;Common Pathway of Fibrin Clot Formation;Integrin cell surface interactions;Integrin alphaIIb beta3 signaling;GRB2:SOS provides linkage to MAPK signaling for Integrins ;p130Cas linkage to MAPK signaling for integrins;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);MAP2K and MAPK activation;Regulation of TLR by endogenous ligand;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF;Post-translational protein phosphorylation;Amyloid fiber formation
2257	FGF12	False	True	Phase 0 - rapid depolarisation
2260	FGFR1	False	True	PI3K Cascade;PIP3 activates AKT signaling;Signaling by FGFR1 amplification mutants;Signaling by activated point mutants of FGFR1;FGFR1b ligand binding and activation;FGFR1c ligand binding and activation;FGFR1c and Klotho ligand binding and activation;Constitutive Signaling by Aberrant PI3K in Cancer;NCAM signaling for neurite out-growth;Signal transduction by L1;Phospholipase C-mediated cascade: FGFR1;Downstream signaling of activated FGFR1;SHC-mediated cascade:FGFR1;PI-3K cascade:FGFR1;FRS-mediated FGFR1 signaling;Negative regulation of FGFR1 signaling;Signaling by FGFR1 in disease;RAF/MAP kinase cascade;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Signaling by plasma membrane FGFR1 fusions
2261	FGFR3	False	True	PI3K Cascade;PIP3 activates AKT signaling;Signaling by activated point mutants of FGFR3;FGFR3b ligand binding and activation;FGFR3c ligand binding and activation;FGFR3 mutant receptor activation;t(4;14) translocations of FGFR3;Constitutive Signaling by Aberrant PI3K in Cancer;Phospholipase C-mediated cascade; FGFR3;SHC-mediated cascade:FGFR3;FRS-mediated FGFR3 signaling;PI-3K cascade:FGFR3;Negative regulation of FGFR3 signaling;RAF/MAP kinase cascade;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Signaling by FGFR3 fusions in cancer;Signaling by FGFR3 point mutants in cancer
2268	FGR	False	True	FCGR activation;Platelet sensitization by LDL;Neutrophil degranulation
2271	FH	False	True	Citric acid cycle (TCA cycle)
2273	FHL1	False	True	NA
2274	FHL2	False	True	PPARA activates gene expression
2280	FKBP1A	False	True	Calcineurin activates NFAT;TGF-beta receptor signaling activates SMADs;TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);TGFBR2 Kinase Domain Mutants in Cancer;TGFBR1 KD Mutants in Cancer;TGFBR1 LBD Mutants in Cancer
2281	FKBP1B	False	True	Stimuli-sensing channels;Ion homeostasis
2286	FKBP2	False	True	NA
2288	FKBP4	False	True	HSP90 chaperone cycle for steroid hormone receptors (SHR);Attenuation phase;ESR-mediated signaling;Estrogen-dependent gene expression
2289	FKBP5	False	True	HSP90 chaperone cycle for steroid hormone receptors (SHR);ESR-mediated signaling;MECP2 regulates neuronal receptors and channels
2296	FOXC1	False	True	NA
2305	FOXM1	False	True	Polo-like kinase mediated events;Cyclin A/B1/B2 associated events during G2/M transition
2308	FOXO1	False	True	AKT phosphorylates targets in the nucleus;Regulation of gene expression in beta cells;AKT-mediated inactivation of FOXO1A;Constitutive Signaling by AKT1 E17K in Cancer;MAPK6/MAPK4 signaling;Interleukin-4 and Interleukin-13 signaling;Regulation of localization of FOXO transcription factors;FOXO-mediated transcription of cell death genes;FOXO-mediated transcription of cell death genes;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes;Regulation of FOXO transcriptional activity by acetylation;Regulation of FOXO transcriptional activity by acetylation;FOXO-mediated transcription of cell cycle genes;FOXO-mediated transcription of cell cycle genes
2309	FOXO3	False	True	Signaling by NODAL;AKT phosphorylates targets in the nucleus;Constitutive Signaling by AKT1 E17K in Cancer;MAPK6/MAPK4 signaling;Interleukin-4 and Interleukin-13 signaling;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;RUNX3 regulates BCL2L11 (BIM) transcription;Regulation of localization of FOXO transcription factors;FOXO-mediated transcription of cell death genes;FOXO-mediated transcription of cell death genes;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes;Regulation of FOXO transcriptional activity by acetylation;FOXO-mediated transcription of cell cycle genes;FOXO-mediated transcription of cell cycle genes
2312	NA	True	False	Formation of the cornified envelope
2314	FLII	False	True	NA
2316	FLNA	False	True	Platelet degranulation ;GP1b-IX-V activation signalling;Cell-extracellular matrix interactions;RHO GTPases activate PAKs;OAS antiviral response
2317	FLNB	True	True	ISG15 antiviral mechanism
2318	FLNC	False	True	Cell-extracellular matrix interactions
2319	FLOT2	False	True	Synaptic adhesion-like molecules
2324	FLT4	False	True	VEGF binds to VEGFR leading to receptor dimerization;NOTCH4 Intracellular Domain Regulates Transcription
2335	FN1	False	True	Platelet degranulation ;Degradation of the extracellular matrix;Degradation of the extracellular matrix;Extracellular matrix organization;Fibronectin matrix formation;Cell surface interactions at the vascular wall;Molecules associated with elastic fibres;Integrin cell surface interactions;Syndecan interactions;Non-integrin membrane-ECM interactions;ECM proteoglycans;Integrin alphaIIb beta3 signaling;GRB2:SOS provides linkage to MAPK signaling for Integrins ;p130Cas linkage to MAPK signaling for integrins;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);MAP2K and MAPK activation;Interleukin-4 and Interleukin-13 signaling;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF;MET activates PTK2 signaling;Post-translational protein phosphorylation
2339	FNTA	False	True	Apoptotic cleavage of cellular proteins;Inactivation, recovery and regulation of the phototransduction cascade
2342	FNTB	False	True	Inactivation, recovery and regulation of the phototransduction cascade
2356	NA	False	True	Metabolism of folate and pterines
2357	FPR1	False	True	G alpha (i) signalling events;Formyl peptide receptors bind formyl peptides and many other ligands;Interleukin-10 signaling;Neutrophil degranulation
2444	FRK	False	True	Neutrophil degranulation;Regulation of PTEN stability and activity
2475	MTOR	False	True	PIP3 activates AKT signaling;Macroautophagy;mTOR signalling;mTORC1-mediated signalling;HSF1-dependent transactivation;Energy dependent regulation of mTOR by LKB1-AMPK;CD28 dependent PI3K/Akt signaling;VEGFR2 mediated vascular permeability;TP53 Regulates Metabolic Genes;Constitutive Signaling by AKT1 E17K in Cancer;Regulation of TP53 Degradation;Regulation of PTEN gene transcription
2495	FTH1	False	True	Scavenging by Class A Receptors;Golgi Associated Vesicle Biogenesis;Neutrophil degranulation;Iron uptake and transport
2521	FUS	False	True	mRNA Splicing - Major Pathway
2534	FYN	False	True	GPVI-mediated activation cascade;Signaling by ERBB2;PIP3 activates AKT signaling;Signaling by SCF-KIT;Signaling by SCF-KIT;Regulation of KIT signaling;Nef and signal transduction;Cell surface interactions at the vascular wall;FCGR activation;PECAM1 interactions;Constitutive Signaling by Aberrant PI3K in Cancer;DAP12 signaling;DAP12 signaling;EPH-Ephrin signaling;Role of LAT2/NTAL/LAB on calcium mobilization;Nephrin family interactions;Nephrin family interactions;NCAM signaling for neurite out-growth;NCAM signaling for neurite out-growth;CD28 co-stimulation;CD28 dependent PI3K/Akt signaling;CD28 dependent Vav1 pathway;CTLA4 inhibitory signaling;EPHB-mediated forward signaling;EPHB-mediated forward signaling;EPHA-mediated growth cone collapse;EPHA-mediated growth cone collapse;Ephrin signaling;Ephrin signaling;EPH-ephrin mediated repulsion of cells;Sema3A PAK dependent Axon repulsion;SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion;SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion;CRMPs in Sema3A signaling;CRMPs in Sema3A signaling;DCC mediated attractive signaling;DCC mediated attractive signaling;VEGFA-VEGFR2 Pathway;Dectin-2 family;CD209 (DC-SIGN) signaling;RAF/MAP kinase cascade;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Platelet Adhesion to exposed collagen;Reelin signalling pathway;Activated NTRK2 signals through FYN;NTRK2 activates RAC1;NTRK2 activates RAC1;Regulation of signaling by CBL;Regulation of signaling by CBL;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
2535	FZD2	False	True	TCF dependent signaling in response to WNT;Class B/2 (Secretin family receptors);Ca2+ pathway;Ca2+ pathway;Asymmetric localization of PCP proteins;Disassembly of the destruction complex and recruitment of AXIN to the membrane;Disassembly of the destruction complex and recruitment of AXIN to the membrane;WNT5A-dependent internalization of FZD2, FZD5 and ROR2
2539	G6PD	False	True	TP53 Regulates Metabolic Genes;Pentose phosphate pathway
2547	XRCC6	False	True	2-LTR circle formation;Cytosolic sensors of pathogen-associated DNA ;IRF3-mediated induction of type I IFN;Nonhomologous End-Joining (NHEJ);Neutrophil degranulation
2548	GAA	False	True	Glycogen storage disease type II (GAA);Neutrophil degranulation;Glycogen breakdown (glycogenolysis)
2549	GAB1	False	True	PI3K Cascade;Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants;PIP3 activates AKT signaling;GAB1 signalosome;PI3K events in ERBB2 signaling;Constitutive Signaling by Aberrant PI3K in Cancer;Constitutive Signaling by EGFRvIII;PI-3K cascade:FGFR1;PI-3K cascade:FGFR2;PI-3K cascade:FGFR3;PI-3K cascade:FGFR4;Signaling by FGFR2 in disease;Signaling by FGFR4 in disease;Signaling by FGFR1 in disease;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;MET activates PI3K/AKT signaling;Signaling by FGFR3 fusions in cancer;Signaling by FGFR3 point mutants in cancer;RET signaling;MET activates PTPN11;MET activates RAP1 and RAC1;MET receptor recycling;Erythropoietin activates Phosphoinositide-3-kinase (PI3K);Activated NTRK2 signals through PI3K
2550	GABBR1	False	True	Activation of G protein gated Potassium channels;G alpha (i) signalling events;Class C/3 (Metabotropic glutamate/pheromone receptors);GABA B receptor activation;Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits
2553	GABPB1	False	True	Transcriptional activation of mitochondrial biogenesis
2560	GABRB1	False	True	GABA A receptor activation;GABA receptor activation
2580	GAK	False	True	Golgi Associated Vesicle Biogenesis;Clathrin-mediated endocytosis
2590	GALNT2	False	True	COPI-independent Golgi-to-ER retrograde traffic;O-linked glycosylation of mucins
2597	GAPDH	True	True	Glycolysis;Gluconeogenesis
2617	GARS	False	True	Cytosolic tRNA aminoacylation;Mitochondrial tRNA aminoacylation
2618	GART	False	True	Purine ribonucleoside monophosphate biosynthesis
2620	GAS2	False	True	Caspase-mediated cleavage of cytoskeletal proteins
2623	GATA1	False	True	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Factors involved in megakaryocyte development and platelet production
2632	GBE1	False	True	Glycogen synthesis;Glycogen storage disease type IV (GBE1)
2634	GBP2	False	True	Interferon gamma signaling;Interferon alpha/beta signaling
2664	GDI1	False	True	Rho GTPase cycle;RAB GEFs exchange GTP for GDP on RABs
2665	GDI2	True	True	Rho GTPase cycle;Neutrophil degranulation;RAB GEFs exchange GTP for GDP on RABs
2670	GFAP	False	True	Nuclear signaling by ERBB4
2673	GFPT1	False	True	XBP1(S) activates chaperone genes;Defective GFPT1 causes CMSTA1;Synthesis of UDP-N-acetyl-glucosamine
2706	GJB2	False	True	Oligomerization of connexins into connexons;Transport of connexins along the secretory pathway;Gap junction assembly;Transport of connexons to the plasma membrane
2709	GJB5	False	True	Gap junction assembly
2717	GLA	False	True	Glycosphingolipid metabolism;Neutrophil degranulation
2739	GLO1	False	True	Pyruvate metabolism
2742	GLRA2	False	True	Neurotransmitter receptors and postsynaptic signal transmission
2744	GLS	False	True	Glutamate Neurotransmitter Release Cycle;TP53 Regulates Metabolic Genes;Amino acid synthesis and interconversion (transamination)
2745	GLRX	False	True	Interconversion of nucleotide di- and triphosphates
2770	GNAI1	False	True	PLC beta mediated events;PLC beta mediated events;Adenylate cyclase inhibitory pathway;Adenylate cyclase inhibitory pathway;G-protein activation;ADP signalling through P2Y purinoceptor 12;Adrenaline,noradrenaline inhibits insulin secretion;Adrenaline,noradrenaline inhibits insulin secretion;G alpha (s) signalling events;G alpha (i) signalling events;G alpha (i) signalling events;G alpha (z) signalling events;Regulation of insulin secretion;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
2771	GNAI2	False	True	PLC beta mediated events;PLC beta mediated events;Adenylate cyclase inhibitory pathway;Adenylate cyclase inhibitory pathway;G-protein activation;ADP signalling through P2Y purinoceptor 12;Adrenaline,noradrenaline inhibits insulin secretion;Adrenaline,noradrenaline inhibits insulin secretion;G alpha (s) signalling events;G alpha (i) signalling events;G alpha (i) signalling events;G alpha (z) signalling events;Regulation of insulin secretion;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
2773	GNAI3	False	True	PLC beta mediated events;PLC beta mediated events;Adenylate cyclase inhibitory pathway;Adenylate cyclase inhibitory pathway;G-protein activation;ADP signalling through P2Y purinoceptor 12;G alpha (s) signalling events;G alpha (i) signalling events;G alpha (i) signalling events;G alpha (z) signalling events;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
2778	GNAS	False	True	Glucagon signaling in metabolic regulation;PKA activation in glucagon signalling;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Prostacyclin signalling through prostacyclin receptor;Prostacyclin signalling through prostacyclin receptor;G alpha (s) signalling events;G alpha (s) signalling events;G alpha (i) signalling events;G alpha (z) signalling events;Glucagon-type ligand receptors;Vasopressin regulates renal water homeostasis via Aquaporins;Hedgehog 'off' state
2782	GNB1	False	True	Activation of G protein gated Potassium channels;Glucagon signaling in metabolic regulation;G-protein activation;Activation of the phototransduction cascade;Activation of the phototransduction cascade;Inactivation, recovery and regulation of the phototransduction cascade;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Olfactory Signaling Pathway;ADP signalling through P2Y purinoceptor 12;G beta:gamma signalling through PI3Kgamma;Prostacyclin signalling through prostacyclin receptor;Prostacyclin signalling through prostacyclin receptor;Adrenaline,noradrenaline inhibits insulin secretion;Adrenaline,noradrenaline inhibits insulin secretion;Ca2+ pathway;Ca2+ pathway;G alpha (q) signalling events;G alpha (12/13) signalling events;G beta:gamma signalling through PLC beta;G alpha (s) signalling events;ADP signalling through P2Y purinoceptor 1;ADP signalling through P2Y purinoceptor 1;G alpha (i) signalling events;G alpha (z) signalling events;Glucagon-type ligand receptors;Thromboxane signalling through TP receptor;Vasopressin regulates renal water homeostasis via Aquaporins;Thrombin signalling through proteinase activated receptors (PARs);Thrombin signalling through proteinase activated receptors (PARs);Presynaptic function of Kainate receptors;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding;G beta:gamma signalling through BTK;G beta:gamma signalling through CDC42;Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits
2783	GNB2	False	True	Activation of G protein gated Potassium channels;Glucagon signaling in metabolic regulation;G-protein activation;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;ADP signalling through P2Y purinoceptor 12;G beta:gamma signalling through PI3Kgamma;Prostacyclin signalling through prostacyclin receptor;Prostacyclin signalling through prostacyclin receptor;Adrenaline,noradrenaline inhibits insulin secretion;Adrenaline,noradrenaline inhibits insulin secretion;Ca2+ pathway;Ca2+ pathway;G alpha (q) signalling events;G alpha (12/13) signalling events;G beta:gamma signalling through PLC beta;G alpha (s) signalling events;ADP signalling through P2Y purinoceptor 1;ADP signalling through P2Y purinoceptor 1;G alpha (i) signalling events;G alpha (z) signalling events;Glucagon-type ligand receptors;Thromboxane signalling through TP receptor;Vasopressin regulates renal water homeostasis via Aquaporins;Thrombin signalling through proteinase activated receptors (PARs);Thrombin signalling through proteinase activated receptors (PARs);Presynaptic function of Kainate receptors;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding;G beta:gamma signalling through BTK;G beta:gamma signalling through CDC42;Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits
2794	GNL1	False	True	NA
2801	GOLGA2	False	True	Golgi Cisternae Pericentriolar Stack Reorganization;Golgi Cisternae Pericentriolar Stack Reorganization;COPII-mediated vesicle transport;COPI-mediated anterograde transport;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
2803	GOLGA4	False	True	Retrograde transport at the Trans-Golgi-Network
2805	GOT1	False	True	Methionine salvage pathway;Gluconeogenesis;Amino acid synthesis and interconversion (transamination)
2806	GOT2	False	True	Degradation of cysteine and homocysteine;Glyoxylate metabolism and glycine degradation;Gluconeogenesis;Amino acid synthesis and interconversion (transamination)
2810	SFN	True	True	Activation of BAD and translocation to mitochondria ;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Translocation of SLC2A4 (GLUT4) to the plasma membrane;RHO GTPases activate PKNs;TP53 Regulates Metabolic Genes;TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;Regulation of localization of FOXO transcription factors
2811	GP1BA	False	True	Intrinsic Pathway of Fibrin Clot Formation;GP1b-IX-V activation signalling;Platelet Adhesion to exposed collagen;Platelet Aggregation (Plug Formation);RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
2812	GP1BB	False	True	Intrinsic Pathway of Fibrin Clot Formation;GP1b-IX-V activation signalling;Platelet Adhesion to exposed collagen;Platelet Aggregation (Plug Formation)
2821	GPI	False	True	TP53 Regulates Metabolic Genes;Neutrophil degranulation;Glycolysis;Gluconeogenesis
2848	GPR25	False	True	G alpha (s) signalling events
2861	GPR37	False	True	Peptide ligand-binding receptors;G alpha (i) signalling events
2868	GRK4	False	True	Inactivation, recovery and regulation of the phototransduction cascade
2870	GRK6	False	True	G alpha (s) signalling events
2875	GPT	False	True	Amino acid synthesis and interconversion (transamination)
2879	GPX4	False	True	Synthesis of 5-eicosatetraenoic acids;Synthesis of 12-eicosatetraenoic acid derivatives;Synthesis of 15-eicosatetraenoic acid derivatives;Biosynthesis of D-series resolvins;Biosynthesis of E-series 18(S)-resolvins;Biosynthesis of aspirin-triggered D-series resolvins;Biosynthesis of E-series 18(R)-resolvins
2882	GPX7	False	True	Detoxification of Reactive Oxygen Species
2885	GRB2	False	True	PI3K Cascade;SOS-mediated signalling;SOS-mediated signalling;Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants;SHC1 events in ERBB2 signaling;SHC1 events in ERBB4 signaling;PIP3 activates AKT signaling;Spry regulation of FGF signaling;Signaling by SCF-KIT;Regulation of KIT signaling;Signalling to RAS;Signalling to RAS;GRB2 events in EGFR signaling;GAB1 signalosome;SHC1 events in EGFR signaling;EGFR downregulation;Signaling by cytosolic FGFR1 fusion mutants;Downstream signal transduction;GRB2 events in ERBB2 signaling;GRB2 events in ERBB2 signaling;PI3K events in ERBB2 signaling;Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;Tie2 Signaling;EGFR Transactivation by Gastrin;Constitutive Signaling by Aberrant PI3K in Cancer;DAP12 signaling;SHC-related events triggered by IGF1R;SHC-related events triggered by IGF1R;Role of LAT2/NTAL/LAB on calcium mobilization;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;FCERI mediated Ca+2 mobilization;GRB2:SOS provides linkage to MAPK signaling for Integrins ;NCAM signaling for neurite out-growth;Costimulation by the CD28 family;CD28 dependent Vav1 pathway;Signal regulatory protein family interactions;Interleukin-3, Interleukin-5 and GM-CSF signaling;Constitutive Signaling by EGFRvIII;SHC-mediated cascade:FGFR1;PI-3K cascade:FGFR1;FRS-mediated FGFR1 signaling;PI-3K cascade:FGFR2;SHC-mediated cascade:FGFR2;FRS-mediated FGFR2 signaling;SHC-mediated cascade:FGFR3;FRS-mediated FGFR3 signaling;PI-3K cascade:FGFR3;FRS-mediated FGFR4 signaling;SHC-mediated cascade:FGFR4;PI-3K cascade:FGFR4;Negative regulation of FGFR1 signaling;Negative regulation of FGFR2 signaling;Negative regulation of FGFR3 signaling;Negative regulation of FGFR4 signaling;Signaling by FGFR2 in disease;Signaling by FGFR4 in disease;Signaling by FGFR1 in disease;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs;RAF/MAP kinase cascade;Negative regulation of MET activity;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Signal attenuation;Insulin receptor signalling cascade;Insulin receptor signalling cascade;MET activates RAS signaling;MET activates PI3K/AKT signaling;Signaling by FGFR3 fusions in cancer;Signaling by FGFR3 point mutants in cancer;RET signaling;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;MET activates PTPN11;InlB-mediated entry of Listeria monocytogenes into host cell;InlB-mediated entry of Listeria monocytogenes into host cell;MET activates RAP1 and RAC1;MET receptor recycling;Interleukin-15 signaling;Interleukin-15 signaling;Activated NTRK2 signals through RAS;Erythropoietin activates RAS;Erythropoietin activates RAS;Activated NTRK2 signals through PI3K;Activated NTRK2 signals through FRS2 and FRS3;Activated NTRK2 signals through FRS2 and FRS3;Activated NTRK3 signals through RAS;Interleukin receptor SHC signaling;Regulation of signaling by CBL;Regulation of signaling by CBL;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
2886	GRB7	False	True	GRB7 events in ERBB2 signaling;Signaling by SCF-KIT;Downstream signal transduction;Tie2 Signaling;RET signaling
2887	GRB10	False	True	Signaling by SCF-KIT;IRS activation;Signal attenuation;Insulin receptor signalling cascade;RET signaling
2904	GRIN2B	False	True	EPHB-mediated forward signaling;EPHB-mediated forward signaling;Unblocking of NMDA receptors, glutamate binding and activation;Unblocking of NMDA receptors, glutamate binding and activation;Ras activation upon Ca2+ influx through NMDA receptor;RAF/MAP kinase cascade;Neurexins and neuroligins;Synaptic adhesion-like molecules;MECP2 regulates neuronal receptors and channels;Activated NTRK2 signals through FYN;Negative regulation of NMDA receptor-mediated neuronal transmission;Long-term potentiation
2908	NR3C1	False	True	HSP90 chaperone cycle for steroid hormone receptors (SHR);Nuclear Receptor transcription pathway;Circadian Clock;SUMOylation of intracellular receptors;PTK6 Expression;Regulation of RUNX2 expression and activity;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
2912	GRM2	False	True	G alpha (i) signalling events;Class C/3 (Metabotropic glutamate/pheromone receptors)
2923	PDIA3	False	True	ER-Phagosome pathway;ER-Phagosome pathway;Calnexin/calreticulin cycle;Antigen Presentation: Folding, assembly and peptide loading of class I MHC;Antigen Presentation: Folding, assembly and peptide loading of class I MHC
2931	GSK3A	False	True	AKT phosphorylates targets in the cytosol;XBP1(S) activates chaperone genes;Constitutive Signaling by AKT1 E17K in Cancer
2934	GSN	True	True	Caspase-mediated cleavage of cytoskeletal proteins;Neutrophil degranulation;Amyloid fiber formation
2935	GSPT1	False	True	Eukaryotic Translation Termination;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
2936	GSR	False	True	Metabolism of ingested H2SeO4 and H2SeO3 into H2Se;Detoxification of Reactive Oxygen Species;Interconversion of nucleotide di- and triphosphates;TP53 Regulates Metabolic Genes
2937	GSS	True	True	Glutathione synthesis and recycling;Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
2947	GSTM3	False	True	Glutathione conjugation
2950	GSTP1	True	True	Glutathione conjugation;Detoxification of Reactive Oxygen Species;Neutrophil degranulation
2952	GSTT1	False	True	Glutathione conjugation
2954	GSTZ1	False	True	Glutathione conjugation;Regulation of pyruvate dehydrogenase (PDH) complex;Phenylalanine and tyrosine catabolism
2956	MSH6	False	True	Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha);Defective Mismatch Repair Associated With MSH2;Defective Mismatch Repair Associated With MSH6
2957	GTF2A1	False	True	HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;RNA Polymerase II Pre-transcription Events;RNA polymerase II transcribes snRNA genes;RNA polymerase II transcribes snRNA genes;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;Estrogen-dependent gene expression
2959	GTF2B	False	True	HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;RNA Polymerase II Pre-transcription Events;RNA polymerase II transcribes snRNA genes;RNA polymerase II transcribes snRNA genes;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance
2963	GTF2F2	False	True	Formation of RNA Pol II elongation complex ;Formation of the Early Elongation Complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of the HIV-1 Early Elongation Complex;RNA Pol II CTD phosphorylation and interaction with CE during HIV infection;HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;Formation of HIV-1 elongation complex containing HIV-1 Tat;Formation of HIV-1 elongation complex containing HIV-1 Tat;Pausing and recovery of Tat-mediated HIV elongation;Abortive elongation of HIV-1 transcript in the absence of Tat;Tat-mediated HIV elongation arrest and recovery;Tat-mediated elongation of the HIV-1 transcript;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;Viral Messenger RNA Synthesis;RNA Polymerase II Pre-transcription Events;TP53 Regulates Transcription of DNA Repair Genes;FGFR2 alternative splicing;RNA polymerase II transcribes snRNA genes;RNA polymerase II transcribes snRNA genes;mRNA Capping;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;Processing of Capped Intron-Containing Pre-mRNA;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Elongation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Pol II CTD phosphorylation and interaction with CE;Signaling by FGFR2 IIIa TM;Estrogen-dependent gene expression
2978	NA	False	True	Inactivation, recovery and regulation of the phototransduction cascade
2983	GUCY1B3	False	True	Nitric oxide stimulates guanylate cyclase;Smooth Muscle Contraction
3005	H1F0	False	True	Activation of DNA fragmentation factor;Formation of Senescence-Associated Heterochromatin Foci (SAHF)
3006	HIST1H1C	False	True	Activation of DNA fragmentation factor;Formation of Senescence-Associated Heterochromatin Foci (SAHF)
3007	NA	False	True	Activation of DNA fragmentation factor;Formation of Senescence-Associated Heterochromatin Foci (SAHF)
3008	HIST1H1E	False	True	Activation of DNA fragmentation factor;Formation of Senescence-Associated Heterochromatin Foci (SAHF)
3009	HIST1H1B	False	True	Activation of DNA fragmentation factor;Formation of Senescence-Associated Heterochromatin Foci (SAHF)
3012	NA	False	True	Meiotic synapsis;Packaging Of Telomere Ends;Pre-NOTCH Transcription and Translation;Formation of the beta-catenin:TCF transactivating complex;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;HDACs deacetylate histones;HATs acetylate histones;HATs acetylate histones;RMTs methylate histone arginines;SIRT1 negatively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;NoRC negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;B-WICH complex positively regulates rRNA expression;DNA methylation;Transcriptional regulation by small RNAs;Activation of anterior HOX genes in hindbrain development during early embryogenesis;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;UCH proteinases;Ub-specific processing proteases;Metalloprotease DUBs;Deposition of new CENPA-containing nucleosomes at the centromere;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Estrogen-dependent gene expression;Meiotic recombination;Amyloid fiber formation
3014	H2AFX	False	True	Meiotic synapsis;Packaging Of Telomere Ends;Pre-NOTCH Transcription and Translation;Formation of the beta-catenin:TCF transactivating complex;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;RMTs methylate histone arginines;SIRT1 negatively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;NoRC negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;B-WICH complex positively regulates rRNA expression;DNA methylation;Transcriptional regulation by small RNAs;Activation of anterior HOX genes in hindbrain development during early embryogenesis;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Processing of DNA double-strand break ends;Deposition of new CENPA-containing nucleosomes at the centromere;G2/M DNA damage checkpoint;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Estrogen-dependent gene expression;Meiotic recombination;Amyloid fiber formation
3015	H2AFZ	False	True	Meiotic synapsis;Packaging Of Telomere Ends;Pre-NOTCH Transcription and Translation;Formation of the beta-catenin:TCF transactivating complex;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;RMTs methylate histone arginines;SIRT1 negatively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;NoRC negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;B-WICH complex positively regulates rRNA expression;DNA methylation;Transcriptional regulation by small RNAs;Activation of anterior HOX genes in hindbrain development during early embryogenesis;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Deposition of new CENPA-containing nucleosomes at the centromere;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Estrogen-dependent gene expression;Meiotic recombination;Amyloid fiber formation
3018	HIST1H2BB	False	True	Meiotic synapsis;Packaging Of Telomere Ends;Pre-NOTCH Transcription and Translation;Formation of the beta-catenin:TCF transactivating complex;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;HDACs deacetylate histones;HATs acetylate histones;HATs acetylate histones;SIRT1 negatively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;NoRC negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;B-WICH complex positively regulates rRNA expression;DNA methylation;Transcriptional regulation by small RNAs;Activation of anterior HOX genes in hindbrain development during early embryogenesis;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Ub-specific processing proteases;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Processing of DNA double-strand break ends;Deposition of new CENPA-containing nucleosomes at the centromere;G2/M DNA damage checkpoint;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;E3 ubiquitin ligases ubiquitinate target proteins;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Estrogen-dependent gene expression;Meiotic recombination;Amyloid fiber formation
3024	HIST1H1A	False	True	Activation of DNA fragmentation factor;Formation of Senescence-Associated Heterochromatin Foci (SAHF)
3028	HSD17B10	False	True	tRNA processing in the mitochondrion;tRNA modification in the mitochondrion;Branched-chain amino acid catabolism;rRNA processing in the mitochondrion
3029	HAGH	False	True	Pyruvate metabolism
3032	HADHB	False	True	Acyl chain remodeling of CL;Beta oxidation of myristoyl-CoA to lauroyl-CoA;mitochondrial fatty acid beta-oxidation of unsaturated fatty acids;Beta oxidation of palmitoyl-CoA to myristoyl-CoA;Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA;Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA;Beta oxidation of octanoyl-CoA to hexanoyl-CoA;Beta oxidation of hexanoyl-CoA to butanoyl-CoA
3034	HAL	True	True	Histidine catabolism
3035	HARS	False	True	Cytosolic tRNA aminoacylation
3039	HBA1	False	True	Erythrocytes take up carbon dioxide and release oxygen;Erythrocytes take up oxygen and release carbon dioxide;Scavenging of heme from plasma
3040	HBA2	False	True	Erythrocytes take up carbon dioxide and release oxygen;Erythrocytes take up oxygen and release carbon dioxide;Scavenging of heme from plasma
3043	HBB	True	True	Erythrocytes take up carbon dioxide and release oxygen;Erythrocytes take up oxygen and release carbon dioxide;Scavenging of heme from plasma;Neutrophil degranulation;Factors involved in megakaryocyte development and platelet production
3054	HCFC1	False	True	Transcriptional activation of mitochondrial biogenesis;HATs acetylate histones;UCH proteinases
3055	HCK	False	True	Nef and signal transduction;FCGR activation;Regulation of signaling by CBL;Regulation of signaling by CBL
3064	HTT	False	True	Regulation of MECP2 expression and activity
3065	HDAC1	False	True	Transcription of E2F targets under negative control by DREAM complex;Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1;G0 and Early G1;p75NTR negatively regulates cell cycle via SC1;Formation of the beta-catenin:TCF transactivating complex;NOTCH1 Intracellular Domain Regulates Transcription;Downregulation of SMAD2/3:SMAD4 transcriptional activity;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;HDACs deacetylate histones;Deactivation of the beta-catenin transactivating complex;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;NoRC negatively regulates rRNA expression;SUMOylation of chromatin organization proteins;Repression of WNT target genes;Repression of WNT target genes;Activation of E2F1 target genes at G1/S;Regulation of TP53 Activity through Acetylation;RNA Polymerase I Transcription Initiation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Regulation of PTEN gene transcription;Regulation of PTEN gene transcription;Estrogen-dependent gene expression;Loss of MECP2 binding ability to 5mC-DNA;Regulation of MECP2 expression and activity;MECP2 regulates neuronal receptors and channels;MECP2 regulates transcription of neuronal ligands;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes;Factors involved in megakaryocyte development and platelet production
3066	HDAC2	False	True	p75NTR negatively regulates cell cycle via SC1;NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;HDACs deacetylate histones;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;NoRC negatively regulates rRNA expression;SUMOylation of chromatin organization proteins;Regulation of TP53 Activity through Acetylation;RNA Polymerase I Transcription Initiation;Regulation of PTEN gene transcription;Regulation of PTEN gene transcription;Regulation of MECP2 expression and activity;MECP2 regulates neuronal receptors and channels;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes;Factors involved in megakaryocyte development and platelet production
3068	HDGF	False	True	XBP1(S) activates chaperone genes
3069	HDLBP	False	True	HDL clearance
3070	HELLS	False	True	NA
3074	HEXB	False	True	Glycosphingolipid metabolism;Keratan sulfate degradation;CS/DS degradation;Hyaluronan uptake and degradation;Defective HEXB causes GM2G2;Neutrophil degranulation
3075	CFH	False	True	Regulation of Complement cascade
3091	HIF1A	False	True	Regulation of gene expression by Hypoxia-inducible Factor;Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;NOTCH1 Intracellular Domain Regulates Transcription;Circadian Clock;Ub-specific processing proteases;Interleukin-4 and Interleukin-13 signaling;PTK6 Expression;PTK6 promotes HIF1A stabilization;Neddylation
3092	HIP1	False	True	Clathrin-mediated endocytosis
3093	UBE2K	False	True	Synthesis of active ubiquitin: roles of E1 and E2 enzymes;Negative regulators of DDX58/IFIH1 signaling;Antigen processing: Ubiquitination & Proteasome degradation
3094	HINT1	False	True	NA
3096	HIVEP1	False	True	NA
3097	NA	False	True	NA
3099	HK2	False	True	Glycolysis
3101	HK3	False	True	Neutrophil degranulation;Glycolysis
3115	HLA-DPB1	False	True	Downstream TCR signaling;Phosphorylation of CD3 and TCR zeta chains;Translocation of ZAP-70 to Immunological synapse;Generation of second messenger molecules;MHC class II antigen presentation;PD-1 signaling;Interferon gamma signaling
3146	HMGB1	False	True	Activation of DNA fragmentation factor;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;Regulation of TLR by endogenous ligand;Neutrophil degranulation;Advanced glycosylation endproduct receptor signaling;Advanced glycosylation endproduct receptor signaling;TRAF6 mediated NF-kB activation
3149	HMGB3	False	True	NA
3157	HMGCS1	False	True	Cholesterol biosynthesis;PPARA activates gene expression;Activation of gene expression by SREBF (SREBP)
3159	HMGA1	False	True	Integration of provirus;2-LTR circle formation;Integration of viral DNA into host genomic DNA;Autointegration results in viral DNA circles;APOBEC3G mediated resistance to HIV-1 infection;Vpr-mediated nuclear import of PICs;Formation of Senescence-Associated Heterochromatin Foci (SAHF)
3162	HMOX1	False	True	Heme degradation;Interleukin-4 and Interleukin-13 signaling;Iron uptake and transport
3163	HMOX2	False	True	Heme degradation;Neutrophil degranulation;Iron uptake and transport
3176	NA	False	True	Metabolism of ingested SeMet, Sec, MeSec into H2Se;Histidine catabolism
3178	HNRNPA1	False	True	FGFR2 alternative splicing;mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA
3181	HNRNPA2B1	False	True	mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
3182	HNRNPAB	False	True	NA
3183	HNRNPC	False	True	SUMOylation of RNA binding proteins;mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA
3184	HNRNPD	False	True	AUF1 (hnRNP D0) binds and destabilizes mRNA;mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA
3185	HNRNPF	False	True	FGFR2 alternative splicing;mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
3187	HNRNPH1	False	True	FGFR2 alternative splicing;mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA
3188	HNRNPH2	False	True	mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA
3189	HNRNPH3	False	True	NA
3190	HNRNPK	False	True	SUMOylation of RNA binding proteins;mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA
3191	HNRNPL	False	True	mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA
3192	HNRNPU	False	True	mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA
3199	HOXA2	False	True	Activation of anterior HOX genes in hindbrain development during early embryogenesis;Regulation of expression of SLITs and ROBOs
3240	HP	True	True	Scavenging of heme from plasma;Neutrophil degranulation
3263	HPX	False	True	Scavenging of heme from plasma
3280	HES1	False	True	Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells;NOTCH1 Intracellular Domain Regulates Transcription;NOTCH2 intracellular domain regulates transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;RUNX2 regulates osteoblast differentiation;RUNX3 regulates NOTCH signaling;RUNX3 regulates NOTCH signaling;NOTCH3 Intracellular Domain Regulates Transcription;NOTCH4 Intracellular Domain Regulates Transcription
3295	HSD17B4	False	True	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol;alpha-linolenic acid (ALA) metabolism;Beta-oxidation of pristanoyl-CoA;Beta-oxidation of very long chain fatty acids;Peroxisomal protein import;Peroxisomal protein import;TYSND1 cleaves peroxisomal proteins
3297	HSF1	False	True	Regulation of HSF1-mediated heat shock response;HSF1 activation;Attenuation phase;HSF1-dependent transactivation
3301	DNAJA1	False	True	HSP90 chaperone cycle for steroid hormone receptors (SHR)
3303	HSPA1A	True	True	Viral RNP Complexes in the Host Cell Nucleus;Regulation of HSF1-mediated heat shock response;HSP90 chaperone cycle for steroid hormone receptors (SHR);Attenuation phase;HSF1-dependent transactivation;AUF1 (hnRNP D0) binds and destabilizes mRNA;Neutrophil degranulation
3304	HSPA1B	True	True	Viral RNP Complexes in the Host Cell Nucleus;Regulation of HSF1-mediated heat shock response;HSP90 chaperone cycle for steroid hormone receptors (SHR);Attenuation phase;HSF1-dependent transactivation;AUF1 (hnRNP D0) binds and destabilizes mRNA;Neutrophil degranulation
3305	HSPA1L	False	True	Regulation of HSF1-mediated heat shock response;HSP90 chaperone cycle for steroid hormone receptors (SHR);Attenuation phase;HSF1-dependent transactivation
3306	HSPA2	False	True	Meiotic synapsis;Regulation of HSF1-mediated heat shock response;HSP90 chaperone cycle for steroid hormone receptors (SHR);Attenuation phase
3308	HSPA4	False	True	Regulation of HSF1-mediated heat shock response
3309	HSPA5	True	True	Platelet degranulation ;Regulation of HSF1-mediated heat shock response;ATF6 (ATF6-alpha) activates chaperones;PERK regulates gene expression;IRE1alpha activates chaperones;ATF6 (ATF6-alpha) activates chaperone genes;Antigen Presentation: Folding, assembly and peptide loading of class I MHC;Antigen Presentation: Folding, assembly and peptide loading of class I MHC
3310	HSPA6	False	True	Regulation of HSF1-mediated heat shock response;Neutrophil degranulation
3311	NA	False	True	NA
3312	HSPA8	True	True	Regulation of HSF1-mediated heat shock response;HSP90 chaperone cycle for steroid hormone receptors (SHR);Attenuation phase;HSF1-dependent transactivation;Lysosome Vesicle Biogenesis;Golgi Associated Vesicle Biogenesis;CHL1 interactions;AUF1 (hnRNP D0) binds and destabilizes mRNA;Interleukin-4 and Interleukin-13 signaling;Neutrophil degranulation;mRNA Splicing - Major Pathway;Clathrin-mediated endocytosis;Protein methylation;GABA synthesis, release, reuptake and degradation
3313	HSPA9	False	True	Mitochondrial protein import;Regulation of HSF1-mediated heat shock response;Cristae formation;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
3315	HSPB1	True	True	VEGFA-VEGFR2 Pathway;AUF1 (hnRNP D0) binds and destabilizes mRNA;MAPK6/MAPK4 signaling
3320	HSP90AA1	True	True	Signaling by ERBB2;Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants;Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation;vRNP Assembly;Regulation of actin dynamics for phagocytic cup formation;eNOS activation;Regulation of PLK1 Activity at G2/M Transition;Scavenging by Class F Receptors;Scavenging by Class F Receptors;HSP90 chaperone cycle for steroid hormone receptors (SHR);HSF1 activation;Attenuation phase;HSF1-dependent transactivation;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Sema3A PAK dependent Axon repulsion;VEGFA-VEGFR2 Pathway;VEGFA-VEGFR2 Pathway;VEGFR2 mediated vascular permeability;Uptake and function of diphtheria toxin;PIWI-interacting RNA (piRNA) biogenesis;Anchoring of the basal body to the plasma membrane;Constitutive Signaling by EGFRvIII;Interleukin-4 and Interleukin-13 signaling;Neutrophil degranulation;The role of GTSE1 in G2/M progression after G2 checkpoint;AURKA Activation by TPX2;Downregulation of ERBB2 signaling;ESR-mediated signaling;Estrogen-dependent gene expression
3326	HSP90AB1	False	True	Regulation of actin dynamics for phagocytic cup formation;HSP90 chaperone cycle for steroid hormone receptors (SHR);HSF1 activation;Attenuation phase;HSF1-dependent transactivation;Sema3A PAK dependent Axon repulsion;Uptake and function of diphtheria toxin;Neutrophil degranulation;The NLRP3 inflammasome;The role of GTSE1 in G2/M progression after G2 checkpoint;Aryl hydrocarbon receptor signalling;ESR-mediated signaling;Estrogen-dependent gene expression
3329	HSPD1	False	True	Mitochondrial protein import;Mitochondrial protein import;TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation
3336	HSPE1	False	True	NA
3337	DNAJB1	False	True	Regulation of HSF1-mediated heat shock response;HSP90 chaperone cycle for steroid hormone receptors (SHR);Attenuation phase;HSF1-dependent transactivation;MAPK6/MAPK4 signaling
3346	NA	False	True	Antimicrobial peptides
3347	HTN3	False	True	Antimicrobial peptides
3376	IARS	False	True	SeMet incorporation into proteins;Cytosolic tRNA aminoacylation
3398	ID2	False	True	NA
3416	IDE	True	True	Ub-specific processing proteases;Peroxisomal protein import;Peroxisomal protein import
3419	IDH3A	False	True	Citric acid cycle (TCA cycle)
3433	IFIT2	False	True	Interferon alpha/beta signaling
3441	IFNA4	False	True	Interferon alpha/beta signaling;Regulation of IFNA signaling;Regulation of IFNA signaling;TRAF6 mediated IRF7 activation;Factors involved in megakaryocyte development and platelet production
3476	IGBP1	False	True	NA
3479	IGF1	False	True	Platelet degranulation ;Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R);IRS-related events triggered by IGF1R;SHC-related events triggered by IGF1R;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Synthesis, secretion, and deacylation of Ghrelin
3480	IGF1R	False	True	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R);IRS-related events triggered by IGF1R;SHC-related events triggered by IGF1R
3481	IGF2	False	True	Platelet degranulation ;Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R);IRS-related events triggered by IGF1R;SHC-related events triggered by IGF1R;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
3488	IGFBP5	False	True	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation
3491	NA	False	True	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation
3500	IGHG1	False	True	NA
3501	NA	False	True	NA
3514	IGKC	False	True	NA
3516	RBPJ	False	True	Pre-NOTCH Transcription and Translation;Pre-NOTCH Transcription and Translation;Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells;NOTCH1 Intracellular Domain Regulates Transcription;NOTCH1 Intracellular Domain Regulates Transcription;NOTCH2 intracellular domain regulates transcription;NOTCH2 intracellular domain regulates transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Notch-HLH transcription pathway;RUNX3 regulates NOTCH signaling;RUNX3 regulates NOTCH signaling;NOTCH3 Intracellular Domain Regulates Transcription;NOTCH3 Intracellular Domain Regulates Transcription;NOTCH4 Intracellular Domain Regulates Transcription;NOTCH4 Intracellular Domain Regulates Transcription
3535	IGL	False	True	NA
3551	IKBKB	False	True	Activation of NF-kappaB in B cells;Activation of NF-kappaB in B cells;ER-Phagosome pathway;NOD1/2 Signaling Pathway;TICAM1, RIP1-mediated IKK complex recruitment ;RIP-mediated NFkB activation via ZBP1;Downstream TCR signaling;p75NTR recruits signalling complexes;NF-kB is activated and signals survival;FCERI mediated NF-kB activation;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;IKBKB deficiency causes SCID;IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR);IkBA variant leads to EDA-ID;CLEC7A (Dectin-1) signaling;MAP3K8 (TPL2)-dependent MAPK1/3 activation;Interleukin-1 signaling;TRAF6 mediated NF-kB activation;NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10;IRAK1 recruits IKK complex;IKK complex recruitment mediated by RIP1;IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
3557	NA	True	False	Interleukin-10 signaling;Interleukin-1 signaling
3575	IL7R	False	True	Interleukin-7 signaling;Interleukin-7 signaling;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis
3581	IL9R	False	True	Interleukin-9 signaling
3608	ILF2	False	True	Neutrophil degranulation
3609	ILF3	False	True	NA
3611	ILK	False	True	Localization of the PINCH-ILK-PARVIN complex to focal adhesions;Cell-extracellular matrix interactions
3613	IMPA2	False	True	Synthesis of IP2, IP, and Ins in the cytosol
3614	IMPDH1	False	True	Neutrophil degranulation;Purine ribonucleoside monophosphate biosynthesis
3615	IMPDH2	False	True	Neutrophil degranulation;Purine ribonucleoside monophosphate biosynthesis
3621	ING1	False	True	NA
3630	INS	False	True	Regulation of gene expression in beta cells;Insulin processing;Insulin processing;Synthesis, secretion, and deacylation of Ghrelin;Regulation of insulin secretion;COPI-mediated anterograde transport;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;IRS activation;Signal attenuation;Insulin receptor signalling cascade;Signaling by Insulin receptor;Insulin receptor recycling;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes;Amyloid fiber formation
3632	INPP5A	False	True	Synthesis of IP2, IP, and Ins in the cytosol
3636	INPPL1	False	True	Synthesis of PIPs at the plasma membrane;Synthesis of IP3 and IP4 in the cytosol;Interleukin receptor SHC signaling
3645	INSRR	False	True	NA
3646	EIF3E	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit
3656	IRAK2	False	True	MyD88:MAL(TIRAP) cascade initiated on plasma membrane;NOD1/2 Signaling Pathway;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;activated TAK1 mediates p38 MAPK activation;JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1;Interleukin-1 signaling;IRAK2 mediated activation of TAK1 complex;TRAF6-mediated induction of TAK1 complex within TLR4 complex;TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation;MyD88 dependent cascade initiated on endosome;IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation;MyD88 cascade initiated on plasma membrane
3658	IREB2	False	True	Iron uptake and transport
3660	IRF2	False	True	Interferon gamma signaling;Interferon alpha/beta signaling;Factors involved in megakaryocyte development and platelet production
3661	IRF3	False	True	ISG15 antiviral mechanism;IRF3 mediated activation of type 1 IFN;IRF3 mediated activation of type 1 IFN;LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production;Regulation of innate immune responses to cytosolic DNA;IRF3-mediated induction of type I IFN;Interferon gamma signaling;TICAM1-dependent activation of IRF3/IRF7;Interferon alpha/beta signaling;TRAF3-dependent IRF activation pathway;TRAF6 mediated IRF7 activation;Negative regulators of DDX58/IFIH1 signaling;Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
3667	IRS1	False	True	PI3K Cascade;IRS-mediated signalling;SOS-mediated signalling;SOS-mediated signalling;PIP3 activates AKT signaling;Interleukin-7 signaling;PI3K/AKT activation;PI3K/AKT activation;Constitutive Signaling by Aberrant PI3K in Cancer;IRS-related events triggered by IGF1R;Signaling by Leptin;RAF/MAP kinase cascade;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;IRS activation;Signal attenuation;Activated NTRK3 signals through PI3K;Growth hormone receptor signaling
3673	ITGA2	False	True	Integrin cell surface interactions;Integrin cell surface interactions;Laminin interactions;Laminin interactions;Syndecan interactions;ECM proteoglycans;CHL1 interactions;Platelet Adhesion to exposed collagen;MET activates PTK2 signaling
3684	ITGAM	False	True	Toll Like Receptor 4 (TLR4) Cascade;Cell surface interactions at the vascular wall;Integrin cell surface interactions;Interleukin-4 and Interleukin-13 signaling;Neutrophil degranulation
3685	ITGAV	False	True	Cross-presentation of particulate exogenous antigens (phagosomes);Elastic fibre formation;PECAM1 interactions;Molecules associated with elastic fibres;Integrin cell surface interactions;Integrin cell surface interactions;Laminin interactions;Syndecan interactions;Syndecan interactions;ECM proteoglycans;VEGFA-VEGFR2 Pathway;Signal transduction by L1;Neutrophil degranulation
3688	ITGB1	False	True	Elastic fibre formation;Fibronectin matrix formation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Cell surface interactions at the vascular wall;Basigin interactions;Molecules associated with elastic fibres;Integrin cell surface interactions;Integrin cell surface interactions;Laminin interactions;Laminin interactions;Syndecan interactions;ECM proteoglycans;Other semaphorin interactions;Signal transduction by L1;Localization of the PINCH-ILK-PARVIN complex to focal adhesions;CHL1 interactions;RHO GTPases Activate Formins;Interleukin-4 and Interleukin-13 signaling;Platelet Adhesion to exposed collagen;MET activates PTK2 signaling;MET interacts with TNS proteins
3690	ITGB3	False	True	Platelet degranulation ;Elastic fibre formation;PECAM1 interactions;Molecules associated with elastic fibres;Integrin cell surface interactions;Integrin cell surface interactions;Syndecan interactions;Syndecan interactions;ECM proteoglycans;Integrin alphaIIb beta3 signaling;GRB2:SOS provides linkage to MAPK signaling for Integrins ;p130Cas linkage to MAPK signaling for integrins;VEGFA-VEGFR2 Pathway;Signal transduction by L1;MAP2K and MAPK activation;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF
3692	EIF6	False	True	NA
3693	ITGB5	False	True	Cross-presentation of particulate exogenous antigens (phagosomes);Molecules associated with elastic fibres;Integrin cell surface interactions;Integrin cell surface interactions;Syndecan interactions;Syndecan interactions;ECM proteoglycans;Smooth Muscle Contraction
3694	ITGB6	False	True	Elastic fibre formation;Molecules associated with elastic fibres;Integrin cell surface interactions;ECM proteoglycans
3697	NA	False	True	NA
3698	ITIH2	False	True	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation
3702	ITK	False	True	Generation of second messenger molecules;FCERI mediated Ca+2 mobilization;FCERI mediated Ca+2 mobilization
3704	ITPA	False	True	Purine catabolism
3709	NA	False	True	PLC beta mediated events;Effects of PIP2 hydrolysis;Elevation of cytosolic Ca2+ levels;DAG and IP3 signaling;Role of phospholipids in phagocytosis;FCERI mediated Ca+2 mobilization;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Ca2+ pathway;Regulation of insulin secretion;VEGFR2 mediated cell proliferation;Ion homeostasis;Ion homeostasis;CLEC7A (Dectin-1) induces NFAT activation;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
3710	ITPR3	False	True	PLC beta mediated events;Effects of PIP2 hydrolysis;Elevation of cytosolic Ca2+ levels;DAG and IP3 signaling;Role of phospholipids in phagocytosis;FCERI mediated Ca+2 mobilization;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Ca2+ pathway;Regulation of insulin secretion;VEGFR2 mediated cell proliferation;Ion homeostasis;Ion homeostasis;CLEC7A (Dectin-1) induces NFAT activation;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
3713	IVL	False	True	Formation of the cornified envelope
3716	JAK1	False	True	Interleukin-6 signaling;Interleukin-6 signaling;MAPK3 (ERK1) activation;MAPK1 (ERK2) activation;ISG15 antiviral mechanism;Interleukin-7 signaling;Interleukin-7 signaling;Other interleukin signaling;RAF/MAP kinase cascade;Interleukin-10 signaling;Interleukin-4 and Interleukin-13 signaling;IL-6-type cytokine receptor ligand interactions;Interferon gamma signaling;Regulation of IFNG signaling;Regulation of IFNG signaling;Interleukin-20 family signaling;Interleukin-15 signaling;Interleukin-15 signaling;Interleukin-35 Signalling;Interleukin-9 signaling;Interleukin-2 signaling;Interleukin-12 signaling;Interleukin-12 signaling;Interleukin-27 signaling;Interleukin-27 signaling;Interleukin-21 signaling;Interferon alpha/beta signaling;Interleukin receptor SHC signaling;Regulation of IFNA signaling;Regulation of IFNA signaling
3717	JAK2	False	True	Interleukin-6 signaling;Interleukin-6 signaling;MAPK3 (ERK1) activation;MAPK1 (ERK2) activation;Prolactin receptor signaling;Prolactin receptor signaling;Signaling by SCF-KIT;Signaling by Leptin;RMTs methylate histone arginines;Interleukin-3, Interleukin-5 and GM-CSF signaling;Interleukin-3, Interleukin-5 and GM-CSF signaling;RAF activation;RAF/MAP kinase cascade;Interleukin-4 and Interleukin-13 signaling;IL-6-type cytokine receptor ligand interactions;Signaling by moderate kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF;Cyclin D associated events in G1;Interferon gamma signaling;Regulation of IFNG signaling;Regulation of IFNG signaling;Interleukin-20 family signaling;Interleukin-35 Signalling;Signaling by Erythropoietin;Interleukin-12 signaling;Interleukin-12 signaling;Interleukin-23 signaling;Interleukin-23 signaling;Interleukin-27 signaling;Interleukin-27 signaling;Erythropoietin activates Phosphoinositide-3-kinase (PI3K);Erythropoietin activates Phosphoinositide-3-kinase (PI3K);Erythropoietin activates Phospholipase C gamma (PLCG);Erythropoietin activates STAT5;Erythropoietin activates RAS;Erythropoietin activates RAS;Interleukin receptor SHC signaling;Growth hormone receptor signaling;Growth hormone receptor signaling;Factors involved in megakaryocyte development and platelet production
3720	JARID2	False	True	PRC2 methylates histones and DNA
3728	JUP	True	True	Adherens junctions interactions;VEGFR2 mediated vascular permeability;Neutrophil degranulation;Keratinization;Formation of the cornified envelope
3735	KARS	False	True	SeMet incorporation into proteins;Cytosolic tRNA aminoacylation;Mitochondrial tRNA aminoacylation
3741	KCNA5	False	True	Voltage gated Potassium channels
3742	KCNA6	False	True	Voltage gated Potassium channels
3755	KCNG1	False	True	Voltage gated Potassium channels
3757	KCNH2	False	True	Voltage gated Potassium channels;Phase 3 - rapid repolarisation
3767	KCNJ11	False	True	ATP sensitive Potassium channels;ABC-family proteins mediated transport;Regulation of insulin secretion;Ion homeostasis;Defective ABCC8 can cause hypoglycemias and hyperglycemias
3775	KCNK1	False	True	Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK);Phase 4 - resting membrane potential
3778	KCNMA1	False	True	Ca2+ activated K+ channels;cGMP effects
3790	KCNS3	False	True	Voltage gated Potassium channels;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
3799	KIF5B	False	True	MHC class II antigen presentation;Insulin processing;RHO GTPases activate KTN1;COPI-dependent Golgi-to-ER retrograde traffic;Kinesins
3801	KIFC3	False	True	Association of TriC/CCT with target proteins during biosynthesis
3816	KLK1	True	True	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
3827	KNG1	False	True	Platelet degranulation ;Intrinsic Pathway of Fibrin Clot Formation;Peptide ligand-binding receptors;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);G alpha (q) signalling events;G alpha (i) signalling events;Post-translational protein phosphorylation
3831	KLC1	False	True	MHC class II antigen presentation;RHO GTPases activate KTN1;COPI-dependent Golgi-to-ER retrograde traffic;Kinesins
3832	KIF11	False	True	MHC class II antigen presentation;COPI-dependent Golgi-to-ER retrograde traffic;Kinesins
3836	KPNA1	False	True	ISG15 antiviral mechanism;Integration of provirus;Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Vpr-mediated nuclear import of PICs;Activation of DNA fragmentation factor
3837	KPNB1	False	True	ISG15 antiviral mechanism;Regulation of cholesterol biosynthesis by SREBP (SREBF);Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Nuclear import of Rev protein;Nuclear import of Rev protein;Activation of DNA fragmentation factor;Neutrophil degranulation
3838	KPNA2	False	True	CaMK IV-mediated phosphorylation of CREB;ISG15 antiviral mechanism;NS1 Mediated Effects on Host Pathways;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;Sensing of DNA Double Strand Breaks;Estrogen-dependent gene expression
3839	KPNA3	False	True	ISG15 antiviral mechanism;NS1 Mediated Effects on Host Pathways
3840	KPNA4	False	True	ISG15 antiviral mechanism;NS1 Mediated Effects on Host Pathways
3848	KRT1	True	True	Neutrophil degranulation;Keratinization;Formation of the cornified envelope
3849	KRT2	True	True	Keratinization;Formation of the cornified envelope
3852	KRT5	False	True	Type I hemidesmosome assembly;Keratinization;Formation of the cornified envelope
3853	KRT6A	True	True	Keratinization;Formation of the cornified envelope
3854	KRT6B	True	True	Keratinization;Formation of the cornified envelope
3856	KRT8	False	True	Keratinization;Formation of the cornified envelope
3857	KRT9	False	True	Keratinization;Formation of the cornified envelope
3858	KRT10	True	True	Keratinization;Formation of the cornified envelope
3860	KRT13	True	True	Keratinization;Formation of the cornified envelope
3861	KRT14	False	True	Type I hemidesmosome assembly;Keratinization;Formation of the cornified envelope
3866	KRT15	True	True	Keratinization;Formation of the cornified envelope
3868	NA	True	False	Keratinization;Formation of the cornified envelope
3872	KRT17	True	True	Keratinization;Formation of the cornified envelope
3875	KRT18	False	True	Keratinization;Formation of the cornified envelope
3880	KRT19	False	True	Keratinization;Formation of the cornified envelope
3881	KRT31	False	True	Keratinization;Formation of the cornified envelope
3884	KRT33B	False	True	Keratinization;Formation of the cornified envelope
3887	KRT81	False	True	Keratinization;Formation of the cornified envelope
3892	KRT86	False	True	Keratinization;Formation of the cornified envelope
3895	KTN1	False	True	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);RHO GTPases activate KTN1;Post-translational protein phosphorylation
3898	LAD1	False	True	NA
3912	LAMB1	False	True	Degradation of the extracellular matrix;Laminin interactions;Laminin interactions;Non-integrin membrane-ECM interactions;ECM proteoglycans;L1CAM interactions;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);MET activates PTK2 signaling;Post-translational protein phosphorylation
3916	LAMP1	True	True	Neutrophil degranulation
3920	LAMP2	True	True	Platelet degranulation ;Neutrophil degranulation
3921	RPSA	True	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
3925	STMN1	False	True	NA
3929	LBP	False	True	Toll Like Receptor 4 (TLR4) Cascade;Transfer of LPS from LBP carrier to CD14;Regulation of TLR by endogenous ligand;Interleukin-4 and Interleukin-13 signaling
3930	LBR	False	True	Cholesterol biosynthesis;Regulation of MECP2 expression and activity
3932	LCK	False	True	GPVI-mediated activation cascade;PIP3 activates AKT signaling;Signaling by SCF-KIT;Signaling by SCF-KIT;Regulation of KIT signaling;Nef and signal transduction;Nef Mediated CD4 Down-regulation;Downstream TCR signaling;Phosphorylation of CD3 and TCR zeta chains;Translocation of ZAP-70 to Immunological synapse;Generation of second messenger molecules;PECAM1 interactions;Constitutive Signaling by Aberrant PI3K in Cancer;DAP12 signaling;DAP12 signaling;CD28 co-stimulation;CD28 dependent PI3K/Akt signaling;CD28 dependent Vav1 pathway;CTLA4 inhibitory signaling;PD-1 signaling;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Interleukin-2 signaling
3933	LCN1	True	True	Transport of fatty acids
3934	LCN2	True	True	Interleukin-4 and Interleukin-13 signaling;Neutrophil degranulation;Metal sequestration by antimicrobial proteins;Iron uptake and transport;Iron uptake and transport
3937	LCP2	False	True	GPVI-mediated activation cascade;Generation of second messenger molecules;Generation of second messenger molecules;DAP12 signaling;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;FCERI mediated Ca+2 mobilization
3939	LDHA	True	True	Pyruvate metabolism
3945	LDHB	False	True	Pyruvate metabolism
3948	LDHC	False	True	Pyruvate metabolism
3949	LDLR	False	True	Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Chylomicron clearance;Chylomicron clearance;LDL clearance;Retinoid metabolism and transport
3956	LGALS1	False	True	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation
3958	LGALS3	False	True	Neutrophil degranulation;Advanced glycosylation endproduct receptor signaling;RUNX1 regulates transcription of genes involved in differentiation of myeloid cells;RUNX2 regulates genes involved in differentiation of myeloid cells
3959	LGALS3BP	False	True	Platelet degranulation
3963	LGALS7	True	True	NA
3978	LIG1	False	True	POLB-Dependent Long Patch Base Excision Repair;Early Phase of HIV Life Cycle;Processive synthesis on the C-strand of the telomere;Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha);Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta);PCNA-Dependent Long Patch Base Excision Repair;Gap-filling DNA repair synthesis and ligation in GG-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Processive synthesis on the lagging strand
3983	ABLIM1	False	True	DCC mediated attractive signaling
3984	LIMK1	False	True	Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;EPHB-mediated forward signaling;Sema3A PAK dependent Axon repulsion;Sema3A PAK dependent Axon repulsion;Sema4D induced cell migration and growth-cone collapse;RHO GTPases Activate ROCKs;RHO GTPases activate PAKs
3985	LIMK2	False	True	EPHB-mediated forward signaling;Sema4D induced cell migration and growth-cone collapse;RHO GTPases Activate ROCKs
3996	LLGL1	False	True	NA
3998	LMAN1	False	True	COPII-mediated vesicle transport;Cargo concentration in the ER;Transport to the Golgi and subsequent modification
4000	LMNA	True	True	Meiotic synapsis;Clearance of Nuclear Envelope Membranes from Chromatin;Initiation of Nuclear Envelope Reformation;Breakdown of the nuclear lamina;XBP1(S) activates chaperone genes;Depolymerisation of the Nuclear Lamina;Signaling by BRAF and RAF fusions;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
4001	LMNB1	False	True	Meiotic synapsis;Formation of Senescence-Associated Heterochromatin Foci (SAHF);Clearance of Nuclear Envelope Membranes from Chromatin;Initiation of Nuclear Envelope Reformation;Breakdown of the nuclear lamina;Depolymerisation of the Nuclear Lamina;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
4005	LMO2	False	True	RUNX1 regulates transcription of genes involved in differentiation of HSCs
4008	LMO7	False	True	Neddylation;Antigen processing: Ubiquitination & Proteasome degradation
4014	LOR	False	True	Formation of the cornified envelope
4026	LPP	False	True	NA
4033	NA	False	True	Neutrophil degranulation
4041	LRP5	False	True	TCF dependent signaling in response to WNT;Negative regulation of TCF-dependent signaling by WNT ligand antagonists;Disassembly of the destruction complex and recruitment of AXIN to the membrane;Disassembly of the destruction complex and recruitment of AXIN to the membrane;Regulation of FZD by ubiquitination;Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling;RNF mutants show enhanced WNT signaling and proliferation
4047	LSS	False	True	Cholesterol biosynthesis;Activation of gene expression by SREBF (SREBP)
4048	LTA4H	False	True	Synthesis of Leukotrienes (LT) and Eoxins (EX);Neutrophil degranulation;Biosynthesis of D-series resolvins;Biosynthesis of protectins;Biosynthesis of E-series 18(S)-resolvins;Biosynthesis of aspirin-triggered D-series resolvins;Biosynthesis of E-series 18(R)-resolvins
4057	LTF	True	True	Mtb iron assimilation by chelation;Neutrophil degranulation;Metal sequestration by antimicrobial proteins;Antimicrobial peptides;Amyloid fiber formation
4067	LYN	False	True	GPVI-mediated activation cascade;Signaling by SCF-KIT;Signaling by SCF-KIT;Regulation of KIT signaling;Cell surface interactions at the vascular wall;FCGR activation;PECAM1 interactions;Fc epsilon receptor (FCERI) signaling;Fc epsilon receptor (FCERI) signaling;EPH-Ephrin signaling;Role of LAT2/NTAL/LAB on calcium mobilization;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;FCERI mediated Ca+2 mobilization;FCERI mediated NF-kB activation;CD28 co-stimulation;CTLA4 inhibitory signaling;EPHB-mediated forward signaling;EPHB-mediated forward signaling;EPHA-mediated growth cone collapse;EPHA-mediated growth cone collapse;EPH-ephrin mediated repulsion of cells;Dectin-2 family;CD209 (DC-SIGN) signaling;CD22 mediated BCR regulation;Cyclin D associated events in G1;Platelet Adhesion to exposed collagen;Signaling by Erythropoietin;Erythropoietin activates Phosphoinositide-3-kinase (PI3K);Erythropoietin activates Phosphoinositide-3-kinase (PI3K);Erythropoietin activates Phospholipase C gamma (PLCG);Erythropoietin activates STAT5;Erythropoietin activates RAS;Erythropoietin activates RAS;Regulation of signaling by CBL;Regulation of signaling by CBL;Growth hormone receptor signaling;Growth hormone receptor signaling;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
4069	NA	True	False	Neutrophil degranulation;Antimicrobial peptides;Amyloid fiber formation
4071	TM4SF1	False	True	NA
4074	M6PR	False	True	Lysosome Vesicle Biogenesis;Retrograde transport at the Trans-Golgi-Network;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis
4082	MARCKS	False	True	Acetylcholine regulates insulin secretion
4086	SMAD1	False	True	Signaling by BMP;Ub-specific processing proteases;RUNX2 regulates bone development
4088	SMAD3	False	True	Signaling by NODAL;Signaling by NODAL;Signaling by Activin;Downregulation of TGF-beta receptor signaling;TGF-beta receptor signaling activates SMADs;Downregulation of SMAD2/3:SMAD4 transcriptional activity;Downregulation of SMAD2/3:SMAD4 transcriptional activity;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;SMAD2/3 Phosphorylation Motif Mutants in Cancer;SMAD4 MH2 Domain Mutants in Cancer;SMAD2/3 MH2 Domain Mutants in Cancer;TGFBR1 KD Mutants in Cancer;Ub-specific processing proteases;RUNX3 regulates CDKN1A transcription;RUNX3 regulates BCL2L11 (BIM) transcription;Interleukin-37 signaling;NOTCH4 Intracellular Domain Regulates Transcription;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes;FOXO-mediated transcription of cell cycle genes;FOXO-mediated transcription of cell cycle genes
4089	SMAD4	False	True	Signaling by NODAL;Signaling by Activin;Signaling by BMP;TGF-beta receptor signaling activates SMADs;Downregulation of SMAD2/3:SMAD4 transcriptional activity;Downregulation of SMAD2/3:SMAD4 transcriptional activity;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;SMAD4 MH2 Domain Mutants in Cancer;SMAD2/3 MH2 Domain Mutants in Cancer;Transcriptional regulation of pluripotent stem cells;Ub-specific processing proteases;RUNX2 regulates bone development;RUNX3 regulates CDKN1A transcription;RUNX3 regulates BCL2L11 (BIM) transcription;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes;FOXO-mediated transcription of cell cycle genes;FOXO-mediated transcription of cell cycle genes
4097	MAFG	False	True	Factors involved in megakaryocyte development and platelet production;Factors involved in megakaryocyte development and platelet production
4100	MAGEA1	False	True	NA
4113	MAGEB2	False	True	NA
4115	MAGEB4	False	True	NA
4118	MAL	False	True	NA
4131	MAP1B	False	True	NA
4133	MAP2	False	True	NA
4134	MAP4	False	True	NA
4137	MAPT	False	True	Caspase-mediated cleavage of cytoskeletal proteins;Activation of AMPK downstream of NMDARs
4139	MARK1	False	True	NA
4140	MARK3	False	True	RAF activation;MAP2K and MAPK activation;Negative regulation of MAPK pathway;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF
4144	MAT2A	False	True	Methylation
4145	MATK	False	True	Downregulation of ERBB2 signaling
4149	MAX	False	True	Transcription of E2F targets under negative control by DREAM complex;Cyclin E associated events during G1/S transition ;Cyclin A:Cdk2-associated events at S phase entry;Transcriptional Regulation by E2F6
4153	MBL2	False	True	Lectin pathway of complement activation;Initial triggering of complement
4168	MCF2	False	True	Axonal growth inhibition (RHOA activation);NRAGE signals death through JNK;Rho GTPase cycle;G alpha (12/13) signalling events
4170	MCL1	False	True	Interleukin-4 and Interleukin-13 signaling
4171	MCM2	False	True	Activation of ATR in response to replication stress;Unwinding of DNA;Assembly of the pre-replicative complex;Orc1 removal from chromatin;Activation of the pre-replicative complex;Switching of origins to a post-replicative state
4172	MCM3	False	True	Activation of ATR in response to replication stress;Unwinding of DNA;Assembly of the pre-replicative complex;Orc1 removal from chromatin;Activation of the pre-replicative complex;Switching of origins to a post-replicative state
4173	MCM4	False	True	Activation of ATR in response to replication stress;Unwinding of DNA;Assembly of the pre-replicative complex;Orc1 removal from chromatin;Activation of the pre-replicative complex;Switching of origins to a post-replicative state
4174	MCM5	False	True	Activation of ATR in response to replication stress;Unwinding of DNA;Assembly of the pre-replicative complex;Orc1 removal from chromatin;Activation of the pre-replicative complex;Switching of origins to a post-replicative state
4175	MCM6	False	True	Activation of ATR in response to replication stress;Unwinding of DNA;Assembly of the pre-replicative complex;Orc1 removal from chromatin;Activation of the pre-replicative complex;Switching of origins to a post-replicative state
4176	MCM7	False	True	Activation of ATR in response to replication stress;Unwinding of DNA;Assembly of the pre-replicative complex;Orc1 removal from chromatin;Activation of the pre-replicative complex;Switching of origins to a post-replicative state
4190	MDH1	False	True	Gluconeogenesis
4191	MDH2	True	True	Gluconeogenesis;Citric acid cycle (TCA cycle)
4193	MDM2	False	True	AKT phosphorylates targets in the cytosol;Oxidative Stress Induced Senescence;Oncogene Induced Senescence;SUMOylation of transcription factors;SUMOylation of ubiquitinylation proteins;Trafficking of AMPA receptors;Constitutive Signaling by AKT1 E17K in Cancer;Ub-specific processing proteases;Regulation of TP53 Activity through Phosphorylation;Regulation of TP53 Degradation;Regulation of TP53 Activity through Methylation;Stabilization of p53;Regulation of RUNX3 expression and activity
4194	MDM4	False	True	Oxidative Stress Induced Senescence;Oncogene Induced Senescence;Ub-specific processing proteases;Regulation of TP53 Activity through Phosphorylation;Regulation of TP53 Degradation;Regulation of TP53 Activity through Methylation;Stabilization of p53
4199	ME1	False	True	PPARA activates gene expression;Pyruvate metabolism
4204	MECP2	False	True	Transcriptional Regulation by MECP2;Transcriptional Regulation by MECP2;Loss of MECP2 binding ability to 5hmC-DNA;Loss of phosphorylation of MECP2 at T308;Loss of MECP2 binding ability to the NCoR/SMRT complex;Loss of MECP2 binding ability to 5mC-DNA;Regulation of MECP2 expression and activity;Regulation of MECP2 expression and activity;MECP2 regulates neuronal receptors and channels;MECP2 regulates neuronal receptors and channels;MECP2 regulates transcription of neuronal ligands;MECP2 regulates transcription factors;MECP2 regulates transcription of genes involved in GABA signaling
4205	MEF2A	False	True	ERK/MAPK targets;CDO in myogenesis
4212	MEIS2	False	True	NA
4214	MAP3K1	False	True	MyD88:MAL(TIRAP) cascade initiated on plasma membrane;FCERI mediated MAPK activation;FCERI mediated MAPK activation;TRAF6 mediated NF-kB activation;TRAF6 mediated NF-kB activation;TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation;MyD88 cascade initiated on plasma membrane
4215	MAP3K3	False	True	Interleukin-1 signaling
4217	MAP3K5	False	True	Oxidative Stress Induced Senescence;Oxidative Stress Induced Senescence
4218	RAB8A	False	True	Translocation of SLC2A4 (GLUT4) to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Anchoring of the basal body to the plasma membrane;VxPx cargo-targeting to cilium;TBC/RABGAPs;RAB geranylgeranylation;RAB GEFs exchange GTP for GDP on RABs
4222	MEOX1	False	True	NA
4223	MEOX2	False	True	NA
4233	MET	False	True	PIP3 activates AKT signaling;Constitutive Signaling by Aberrant PI3K in Cancer;Sema4D mediated inhibition of cell attachment and migration;RAF/MAP kinase cascade;MET Receptor Activation;Negative regulation of MET activity;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;MET activates RAS signaling;MET activates PI3K/AKT signaling;MET activates PTPN11;MET activates PTK2 signaling;InlB-mediated entry of Listeria monocytogenes into host cell;InlB-mediated entry of Listeria monocytogenes into host cell;MET interacts with TNS proteins;MET activates RAP1 and RAC1;MET receptor recycling;MET activates STAT3;MECP2 regulates neuronal receptors and channels
4234	METTL1	False	True	tRNA modification in the nucleus and cytosol
4236	MFAP1	False	True	Molecules associated with elastic fibres
4253	CTAGE5	False	True	Cargo concentration in the ER
4259	MGST3	False	True	Glutathione conjugation;Aflatoxin activation and detoxification
4282	MIF	False	True	Cell surface interactions at the vascular wall;Neutrophil degranulation;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
4284	MIP	False	True	Passive transport by Aquaporins
4287	ATXN3	False	True	Josephin domain DUBs;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
4288	MKI67	False	True	NA
4289	MKLN1	False	True	NA
4292	MLH1	False	True	Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha);Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta);Defective Mismatch Repair Associated With MLH1;Defective Mismatch Repair Associated With PMS2;TP53 Regulates Transcription of DNA Repair Genes;Meiotic recombination
4293	MAP3K9	False	True	NA
4301	MLLT4	False	True	Adherens junctions interactions;Adherens junctions interactions
4303	FOXO4	False	True	AKT phosphorylates targets in the nucleus;Constitutive Signaling by AKT1 E17K in Cancer;Ub-specific processing proteases;Regulation of localization of FOXO transcription factors;FOXO-mediated transcription of cell death genes;FOXO-mediated transcription of cell death genes;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes;Regulation of FOXO transcriptional activity by acetylation;FOXO-mediated transcription of cell cycle genes;FOXO-mediated transcription of cell cycle genes
4306	NR3C2	False	True	HSP90 chaperone cycle for steroid hormone receptors (SHR);Nuclear Receptor transcription pathway;SUMOylation of intracellular receptors
4311	MME	False	True	Metabolism of Angiotensinogen to Angiotensins;Neutrophil degranulation
4313	MMP2	False	True	Collagen degradation;Collagen degradation;Degradation of the extracellular matrix;Degradation of the extracellular matrix;Activation of Matrix Metalloproteinases;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);EPH-ephrin mediated repulsion of cells;Interleukin-4 and Interleukin-13 signaling
4329	ALDH6A1	False	True	Branched-chain amino acid catabolism
4342	MOS	False	True	NA
4351	MPI	False	True	Defective MPI causes MPI-CDG (CDG-1b);Synthesis of GDP-mannose
4361	MRE11A	False	True	Cytosolic sensors of pathogen-associated DNA ;DNA Damage/Telomere Stress Induced Senescence;IRF3-mediated induction of type I IFN;HDR through Single Strand Annealing (SSA);HDR through MMEJ (alt-NHEJ);HDR through Homologous Recombination (HRR);Sensing of DNA Double Strand Breaks;Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA);Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Resolution of D-loop Structures through Holliday Junction Intermediates;Nonhomologous End-Joining (NHEJ);Homologous DNA Pairing and Strand Exchange;Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;Regulation of TP53 Activity through Phosphorylation;G2/M DNA damage checkpoint;Meiotic recombination
4430	NA	False	True	NA
4478	MSN	False	True	Recycling pathway of L1;Recycling pathway of L1;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
4481	MSR1	False	True	Scavenging by Class A Receptors;Scavenging by Class A Receptors
4496	NA	False	True	Metallothioneins bind metals
4507	MTAP	False	True	Methionine salvage pathway;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
4513	COX2	False	True	TP53 Regulates Metabolic Genes;Respiratory electron transport
4522	MTHFD1	False	True	Metabolism of folate and pterines
4528	NA	False	True	Mitochondrial translation initiation
4580	MTX1	False	True	Mitochondrial protein import;Cristae formation
4586	MUC5AC	False	True	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC);Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS);Defective GALNT12 causes colorectal cancer 1 (CRCS1);Dectin-2 family;O-linked glycosylation of mucins;Termination of O-glycan biosynthesis
4589	NA	True	False	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC);Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS);Defective GALNT12 causes colorectal cancer 1 (CRCS1);Dectin-2 family;O-linked glycosylation of mucins;Termination of O-glycan biosynthesis
4591	TRIM37	False	True	Antigen processing: Ubiquitination & Proteasome degradation
4593	MUSK	False	True	ECM proteoglycans
4595	MUTYH	False	True	Recognition and association of DNA glycosylase with site containing an affected purine;Cleavage of the damaged purine;Displacement of DNA glycosylase by APEX1;Defective MUTYH substrate binding;Defective MUTYH substrate processing
4597	MVD	False	True	Cholesterol biosynthesis;Activation of gene expression by SREBF (SREBP);Synthesis of Dolichyl-phosphate
4598	MVK	False	True	Cholesterol biosynthesis;Activation of gene expression by SREBF (SREBP)
4602	MYB	False	True	RUNX1 regulates transcription of genes involved in differentiation of HSCs;Estrogen-dependent gene expression;Factors involved in megakaryocyte development and platelet production
4607	MYBPC3	False	True	Striated Muscle Contraction
4609	MYC	False	True	Transcription of E2F targets under negative control by DREAM complex;NOTCH1 Intracellular Domain Regulates Transcription;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Binding of TCF/LEF:CTNNB1 to target gene promoters;MAPK6/MAPK4 signaling;Ub-specific processing proteases;Interleukin-4 and Interleukin-13 signaling;Cyclin E associated events during G1/S transition ;Cyclin A:Cdk2-associated events at S phase entry;TFAP2 (AP-2) family regulates transcription of cell cycle factors;RUNX3 regulates WNT signaling;Estrogen-dependent gene expression
4619	MYH1	False	True	NA
4627	MYH9	True	True	Translocation of SLC2A4 (GLUT4) to the plasma membrane;Regulation of actin dynamics for phagocytic cup formation;EPHA-mediated growth cone collapse;Sema4D induced cell migration and growth-cone collapse;RHO GTPases activate PKNs;RHO GTPases activate CIT;RHO GTPases Activate ROCKs;RHO GTPases activate PAKs;RHO GTPases activate PAKs
4628	MYH10	False	True	EPHA-mediated growth cone collapse;Sema4D induced cell migration and growth-cone collapse;RHO GTPases activate PKNs;RHO GTPases activate CIT;RHO GTPases Activate ROCKs;RHO GTPases activate PAKs;RHO GTPases activate PAKs
4629	MYH11	False	True	EPHA-mediated growth cone collapse;Sema4D induced cell migration and growth-cone collapse;Smooth Muscle Contraction;RHO GTPases activate PKNs;RHO GTPases activate CIT;RHO GTPases Activate ROCKs;RHO GTPases activate PAKs;RHO GTPases activate PAKs
4633	MYL2	False	True	Striated Muscle Contraction
4635	MYL4	False	True	Striated Muscle Contraction
4637	MYL6	False	True	EPHA-mediated growth cone collapse;Sema4D induced cell migration and growth-cone collapse;Smooth Muscle Contraction;RHO GTPases activate PKNs;RHO GTPases activate CIT;RHO GTPases Activate ROCKs;RHO GTPases activate PAKs;RHO GTPases activate PAKs
4638	MYLK	False	True	Smooth Muscle Contraction;RHO GTPases activate PAKs;RHO GTPases activate PAKs
4641	MYO1C	False	True	Translocation of SLC2A4 (GLUT4) to the plasma membrane;Regulation of actin dynamics for phagocytic cup formation;B-WICH complex positively regulates rRNA expression
4643	MYO1E	False	True	NA
4644	MYO5A	False	True	Translocation of SLC2A4 (GLUT4) to the plasma membrane;Regulation of actin dynamics for phagocytic cup formation;Insulin processing
4645	MYO5B	False	True	Vasopressin regulates renal water homeostasis via Aquaporins
4646	MYO6	False	True	Gap junction degradation;Trafficking of AMPA receptors
4654	MYOD1	False	True	CDO in myogenesis;CDO in myogenesis
4659	PPP1R12A	False	True	Regulation of PLK1 Activity at G2/M Transition;RHO GTPases activate PKNs;RHO GTPases activate PKNs;RHO GTPases activate CIT;RHO GTPases Activate ROCKs;RHO GTPases activate PAKs;RHO GTPases activate PAKs
4660	PPP1R12B	False	True	Regulation of PLK1 Activity at G2/M Transition;RHO GTPases activate PKNs;RHO GTPases activate PKNs;RHO GTPases activate CIT;RHO GTPases Activate ROCKs;RHO GTPases activate PAKs;RHO GTPases activate PAKs
4664	NAB1	False	True	NA
4665	NAB2	False	True	NA
4666	NACA	False	True	NA
4670	HNRNPM	False	True	FGFR2 alternative splicing;mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA
4673	NAP1L1	False	True	NA
4676	NAP1L4	False	True	NA
4677	NARS	False	True	Cytosolic tRNA aminoacylation
4686	NCBP1	False	True	Cleavage of Growing Transcript in the Termination Region ;SLBP independent Processing of Histone Pre-mRNAs;Formation of RNA Pol II elongation complex ;Formation of the Early Elongation Complex;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Formation of HIV elongation complex in the absence of HIV Tat;Formation of the HIV-1 Early Elongation Complex;Formation of HIV-1 elongation complex containing HIV-1 Tat;Abortive elongation of HIV-1 transcript in the absence of Tat;snRNP Assembly;RNA Polymerase II Pre-transcription Events;FGFR2 alternative splicing;RNA polymerase II transcribes snRNA genes;mRNA Capping;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;mRNA 3'-end processing;Processing of Capped Intron-Containing Pre-mRNA;SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs;Processing of Intronless Pre-mRNAs;Signaling by FGFR2 IIIa TM;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
4689	NCF4	False	True	ROS, RNS production in phagocytes;Cross-presentation of particulate exogenous antigens (phagosomes);Detoxification of Reactive Oxygen Species;VEGFA-VEGFR2 Pathway;RHO GTPases Activate NADPH Oxidases
4690	NCK1	False	True	Downstream signal transduction;Generation of second messenger molecules;Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;Nephrin family interactions;DCC mediated attractive signaling;DCC mediated attractive signaling;Activation of RAC1;VEGFA-VEGFR2 Pathway;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
4691	NCL	False	True	Major pathway of rRNA processing in the nucleolus and cytosol
4702	NDUFA8	False	True	Respiratory electron transport;Complex I biogenesis
4704	NDUFA9	False	True	Respiratory electron transport;Complex I biogenesis
4706	NDUFAB1	False	True	Glyoxylate metabolism and glycine degradation;Respiratory electron transport;Complex I biogenesis;Mitochondrial Fatty Acid Beta-Oxidation
4707	NDUFB1	False	True	Respiratory electron transport;Complex I biogenesis
4708	NDUFB2	False	True	Respiratory electron transport;Complex I biogenesis
4713	NDUFB7	False	True	Respiratory electron transport;Complex I biogenesis
4723	NDUFV1	False	True	Respiratory electron transport;Complex I biogenesis
4724	NDUFS4	False	True	Respiratory electron transport;Complex I biogenesis
4733	DRG1	False	True	NA
4734	NEDD4	False	True	ISG15 antiviral mechanism;Downregulation of ERBB4 signaling;Regulation of PTEN localization;Regulation of PTEN stability and activity;Antigen processing: Ubiquitination & Proteasome degradation
4735	SEPT2	False	True	Anchoring of the basal body to the plasma membrane
4736	RPL10A	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
4741	NEFM	False	True	NA
4747	NEFL	False	True	Unblocking of NMDA receptors, glutamate binding and activation;Unblocking of NMDA receptors, glutamate binding and activation;Ras activation upon Ca2+ influx through NMDA receptor;RAF/MAP kinase cascade;Negative regulation of NMDA receptor-mediated neuronal transmission;Long-term potentiation
4758	NEU1	False	True	Glycosphingolipid metabolism;Sialic acid metabolism;Defective NEU1 causes sialidosis;Neutrophil degranulation
4775	NFATC3	False	True	Calcineurin activates NFAT;Calcineurin activates NFAT;FCERI mediated Ca+2 mobilization;CLEC7A (Dectin-1) induces NFAT activation
4776	NFATC4	False	True	NA
4779	NFE2L1	False	True	NA
4782	NFIC	False	True	RNA Polymerase III Transcription Termination;RNA Polymerase III Abortive And Retractive Initiation
4790	NFKB1	False	True	Activation of NF-kappaB in B cells;RIP-mediated NFkB activation via ZBP1;Regulated proteolysis of p75NTR;Downstream TCR signaling;NF-kB is activated and signals survival;Senescence-Associated Secretory Phenotype (SASP);FCERI mediated NF-kB activation;DEx/H-box helicases activate type I IFN and inflammatory cytokines production ;PKMTs methylate histone lysines;Transcriptional regulation of white adipocyte differentiation;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;Interleukin-1 processing;IkBA variant leads to EDA-ID;CLEC7A (Dectin-1) signaling;CD209 (DC-SIGN) signaling;CLEC7A/inflammasome pathway;MAP3K8 (TPL2)-dependent MAPK1/3 activation;Neutrophil degranulation;The NLRP3 inflammasome;Interleukin-1 signaling;TRAF6 mediated NF-kB activation
4792	NFKBIA	False	True	Activation of NF-kappaB in B cells;RIP-mediated NFkB activation via ZBP1;Downstream TCR signaling;NF-kB is activated and signals survival;FCERI mediated NF-kB activation;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;SUMOylation of immune response proteins;IkBA variant leads to EDA-ID;CLEC7A (Dectin-1) signaling;Ub-specific processing proteases;Interleukin-1 signaling;TRAF6 mediated NF-kB activation
4794	NFKBIE	False	True	Activation of NF-kappaB in B cells
4798	NFRKB	False	True	UCH proteinases;DNA Damage Recognition in GG-NER
4800	NFYA	False	True	PPARA activates gene expression;Activation of gene expression by SREBF (SREBP);Activation of gene expression by SREBF (SREBP);ATF4 activates genes;ATF6 (ATF6-alpha) activates chaperone genes;FOXO-mediated transcription of cell death genes
4801	NFYB	False	True	PPARA activates gene expression;Activation of gene expression by SREBF (SREBP);Activation of gene expression by SREBF (SREBP);ATF4 activates genes;ATF6 (ATF6-alpha) activates chaperone genes;FOXO-mediated transcription of cell death genes
4802	NFYC	False	True	PPARA activates gene expression;Activation of gene expression by SREBF (SREBP);Activation of gene expression by SREBF (SREBP);ATF4 activates genes;ATF6 (ATF6-alpha) activates chaperone genes;FOXO-mediated transcription of cell death genes
4815	NINJ2	False	True	NA
4817	NIT1	False	True	NA
4818	NKG7	False	True	NA
4830	NME1	False	True	Interconversion of nucleotide di- and triphosphates
4831	NME2	False	True	Interconversion of nucleotide di- and triphosphates;Neutrophil degranulation
4839	NOP2	False	True	rRNA modification in the nucleus and cytosol;TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation
4841	NONO	False	True	NA
4843	NOS2	False	True	ROS, RNS production in phagocytes;Nitric oxide stimulates guanylate cyclase;Interleukin-4 and Interleukin-13 signaling;Peroxisomal protein import;Peroxisomal protein import
4846	NOS3	False	True	ROS, RNS production in phagocytes;Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation;eNOS activation;NOSTRIN mediated eNOS trafficking;NOSIP mediated eNOS trafficking;Nitric oxide stimulates guanylate cyclase;VEGFR2 mediated vascular permeability
4848	CNOT2	False	True	Deadenylation of mRNA;TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
4849	CNOT3	False	True	Deadenylation of mRNA;TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
4860	PNP	True	True	Neutrophil degranulation;Purine salvage;Purine catabolism
4862	NPAS2	False	True	BMAL1:CLOCK,NPAS2 activates circadian gene expression;BMAL1:CLOCK,NPAS2 activates circadian gene expression;PPARA activates gene expression;PPARA activates gene expression;Circadian Clock;Circadian Clock
4863	NPAT	False	True	NA
4868	NPHS1	False	True	Nephrin family interactions;Nephrin family interactions
4869	NPM1	False	True	Nuclear import of Rev protein;Nuclear import of Rev protein;SUMOylation of transcription cofactors;Deposition of new CENPA-containing nucleosomes at the centromere;TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain;TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation
4898	NRD1	False	True	NA
4904	YBX1	False	True	mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;Noncanonical activation of NOTCH3
4914	NTRK1	False	True	PLC-gamma1 signalling;Signalling to RAS;Frs2-mediated activation;Frs2-mediated activation;ARMS-mediated activation;ARMS-mediated activation;Retrograde neurotrophin signalling;Retrograde neurotrophin signalling;NGF-independant TRKA activation;TRKA activation by NGF;TRKA activation by NGF;Signalling to p38 via RIT and RIN;PI3K/AKT activation;PI3K/AKT activation;Signalling to STAT3
4915	NTRK2	False	True	NGF-independant TRKA activation;BDNF activates NTRK2 (TRKB) signaling;NTF3 activates NTRK2 (TRKB) signaling;NTF4 activates NTRK2 (TRKB) signaling;Activated NTRK2 signals through RAS;Activated NTRK2 signals through PLCG1;Activated NTRK2 signals through PLCG1;Activated NTRK2 signals through PI3K;Activated NTRK2 signals through FRS2 and FRS3;Activated NTRK2 signals through FRS2 and FRS3;Activated NTRK2 signals through FYN;NTRK2 activates RAC1;NTRK2 activates RAC1;Activated NTRK2 signals through CDK5
4916	NTRK3	False	True	Receptor-type tyrosine-protein phosphatases;NTF3 activates NTRK3 signaling;NTF3 activates NTRK3 signaling;Signaling by NTRK3 (TRKC);Activated NTRK3 signals through PLCG1;Activated NTRK3 signals through PLCG1;Activated NTRK3 signals through RAS;Activated NTRK3 signals through PI3K;Activated NTRK3 signals through PI3K;NTRK3 as a dependence receptor
4919	ROR1	False	True	WNT5A-dependent internalization of FZD2, FZD5 and ROR2
4920	ROR2	False	True	PCP/CE pathway;WNT5A-dependent internalization of FZD2, FZD5 and ROR2
4921	DDR2	False	True	Non-integrin membrane-ECM interactions
4924	NUCB1	False	True	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation
4926	NUMA1	False	True	Recruitment of NuMA to mitotic centrosomes;Mitotic Prophase
4928	NUP98	False	True	ISG15 antiviral mechanism;Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Rev-mediated nuclear export of HIV RNA;Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Viral Messenger RNA Synthesis;NEP/NS2 Interacts with the Cellular Export Machinery;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;snRNP Assembly;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;SUMOylation of DNA damage response and repair proteins;SUMOylation of ubiquitinylation proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;SUMOylation of SUMOylation proteins;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins;Transcriptional regulation by small RNAs;RHO GTPases Activate Formins;tRNA processing in the nucleus;Mitotic Prometaphase
4931	NVL	False	True	NA
4942	OAT	False	True	Amino acid synthesis and interconversion (transamination)
4967	OGDH	False	True	Glyoxylate metabolism and glycine degradation;Lysine catabolism;Citric acid cycle (TCA cycle)
4976	OPA1	False	True	Regulation of Apoptosis
4995	NA	False	True	Olfactory Signaling Pathway
4999	ORC2	False	True	E2F-enabled inhibition of pre-replication complex formation;Activation of ATR in response to replication stress;Assembly of the ORC complex at the origin of replication;CDC6 association with the ORC:origin complex;CDT1 association with the CDC6:ORC:origin complex;Assembly of the pre-replicative complex;Orc1 removal from chromatin;Activation of the pre-replicative complex
5000	ORC4	False	True	E2F-enabled inhibition of pre-replication complex formation;Activation of ATR in response to replication stress;Assembly of the ORC complex at the origin of replication;CDC6 association with the ORC:origin complex;CDT1 association with the CDC6:ORC:origin complex;Assembly of the pre-replicative complex;Orc1 removal from chromatin;Activation of the pre-replicative complex
5001	ORC5	False	True	E2F-enabled inhibition of pre-replication complex formation;Activation of ATR in response to replication stress;Assembly of the ORC complex at the origin of replication;CDC6 association with the ORC:origin complex;CDT1 association with the CDC6:ORC:origin complex;Assembly of the pre-replicative complex;Orc1 removal from chromatin;Activation of the pre-replicative complex
5004	ORM1	True	True	Platelet degranulation ;Neutrophil degranulation
5005	ORM2	False	True	Platelet degranulation ;Neutrophil degranulation
5019	OXCT1	False	True	Utilization of Ketone Bodies
5034	P4HB	False	True	Collagen biosynthesis and modifying enzymes;Detoxification of Reactive Oxygen Species;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Hedgehog ligand biogenesis;VLDL assembly;Post-translational protein phosphorylation;Chylomicron assembly;Interleukin-12 signaling;Interleukin-23 signaling
5036	PA2G4	False	True	Neutrophil degranulation
5037	PEBP1	False	True	MAP2K and MAPK activation;Negative regulation of MAPK pathway;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF
5042	PABPC3	False	True	NA
5048	PAFAH1B1	False	True	Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;RHO GTPases Activate Formins;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;AURKA Activation by TPX2
5049	PAFAH1B2	False	True	Neutrophil degranulation;COPI-independent Golgi-to-ER retrograde traffic
5052	PRDX1	True	True	Detoxification of Reactive Oxygen Species;TP53 Regulates Metabolic Genes;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
5054	SERPINE1	False	True	Platelet degranulation ;BMAL1:CLOCK,NPAS2 activates circadian gene expression;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;ECM proteoglycans;Dissolution of Fibrin Clot
5062	PAK2	False	True	Nef and signal transduction;Generation of second messenger molecules;Regulation of PAK-2p34 activity by PS-GAP/RHG10;Regulation of activated PAK-2p34 by proteasome mediated degradation;Stimulation of the cell death response by PAK-2p34;FCERI mediated MAPK activation;FCERI mediated MAPK activation;CD28 dependent Vav1 pathway;Ephrin signaling;Sema3A PAK dependent Axon repulsion;Activation of RAC1;VEGFA-VEGFR2 Pathway;Smooth Muscle Contraction;VEGFR2 mediated vascular permeability;CD209 (DC-SIGN) signaling;RHO GTPases activate PAKs;RHO GTPases activate PAKs;MAPK6/MAPK4 signaling;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
5071	PARK2	False	True	Pink/Parkin Mediated Mitophagy;Josephin domain DUBs;Amyloid fiber formation;Antigen processing: Ubiquitination & Proteasome degradation
5074	PAWR	False	True	NA
5093	PCBP1	False	True	mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA
5094	PCBP2	False	True	mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA;Negative regulators of DDX58/IFIH1 signaling
5097	PCDH1	False	True	NA
5108	PCM1	False	True	Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;AURKA Activation by TPX2
5110	PCMT1	False	True	Protein repair
5111	PCNA	False	True	Translesion synthesis by REV1;Recognition of DNA damage by PCNA-containing replication complex;Translesion Synthesis by POLH;Transcription of E2F targets under negative control by DREAM complex;Polymerase switching on the C-strand of the telomere;Processive synthesis on the C-strand of the telomere;Telomere C-strand (Lagging Strand) Synthesis;Removal of the Flap Intermediate from the C-strand;SUMOylation of DNA replication proteins;Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha);Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta);Activation of E2F1 target genes at G1/S;PCNA-Dependent Long Patch Base Excision Repair;Translesion synthesis by POLK;Translesion synthesis by POLI;Termination of translesion DNA synthesis;HDR through Homologous Recombination (HRR);Gap-filling DNA repair synthesis and ligation in GG-NER;Dual Incision in GG-NER;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest;Polymerase switching;Removal of the Flap Intermediate;Processive synthesis on the lagging strand;E3 ubiquitin ligases ubiquitinate target proteins
5116	PCNT	False	True	Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;AURKA Activation by TPX2
5127	CDK16	False	True	NA
5129	CDK18	False	True	NA
5139	PDE3A	False	True	cGMP effects;G alpha (s) signalling events
5142	PDE4B	False	True	DARPP-32 events;G alpha (s) signalling events
5159	PDGFRB	False	True	PIP3 activates AKT signaling;Downstream signal transduction;Signaling by PDGF;Constitutive Signaling by Aberrant PI3K in Cancer;RAF/MAP kinase cascade;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
5160	PDHA1	False	True	Regulation of pyruvate dehydrogenase (PDH) complex;Glyoxylate metabolism and glycine degradation;Signaling by Retinoic Acid;Pyruvate metabolism
5162	PDHB	False	True	Regulation of pyruvate dehydrogenase (PDH) complex;Glyoxylate metabolism and glycine degradation;Signaling by Retinoic Acid;Pyruvate metabolism
5168	ENPP2	False	True	Vitamin B5 (pantothenate) metabolism
5173	PDYN	False	True	Opioid Signalling;G-protein activation;Peptide ligand-binding receptors;G alpha (i) signalling events
5178	PEG3	False	True	NA
5184	PEPD	False	True	NA
5197	NA	False	True	Common Pathway of Fibrin Clot Formation;Cell surface interactions at the vascular wall
5198	PFAS	False	True	Purine ribonucleoside monophosphate biosynthesis
5202	PFDN2	False	True	Prefoldin mediated transfer of substrate  to CCT/TriC
5208	PFKFB2	False	True	Glycolysis
5213	PFKM	False	True	Glycolysis
5214	PFKP	False	True	Glycolysis
5216	PFN1	False	True	Platelet degranulation ;Signaling by ROBO receptors;PCP/CE pathway;RHO GTPases Activate Formins;RHO GTPases Activate Formins
5217	PFN2	False	True	Signaling by ROBO receptors;RHO GTPases Activate Formins;RHO GTPases Activate Formins
5218	CDK14	False	True	NA
5223	PGAM1	False	True	Neutrophil degranulation;Glycolysis;Gluconeogenesis
5224	PGAM2	False	True	Glycolysis;Gluconeogenesis
5226	PGD	False	True	Pentose phosphate pathway
5230	PGK1	True	True	Glycolysis;Gluconeogenesis
5232	PGK2	False	True	Glycolysis;Gluconeogenesis
5236	PGM1	False	True	Glycogen synthesis;Defective PGM1 causes PGM1-CDG (CDG1t);Neutrophil degranulation;Glycogen breakdown (glycogenolysis);Galactose catabolism
5239	PGM5	False	True	NA
5245	PHB	False	True	RAF activation;Signaling by moderate kinase activity BRAF mutants;Signaling by RAS mutants;Paradoxical activation of RAF signaling by kinase inactive BRAF;Processing of SMDT1
5250	SLC25A3	False	True	NA
5255	PHKA1	False	True	Glycogen breakdown (glycogenolysis);Glycogen breakdown (glycogenolysis)
5265	SERPINA1	True	True	Platelet degranulation ;COPII-mediated vesicle transport;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Cargo concentration in the ER;Neutrophil degranulation;Post-translational protein phosphorylation
5266	PI3	False	True	Antimicrobial peptides;Formation of the cornified envelope
5267	SERPINA4	False	True	Platelet degranulation
5268	SERPINB5	True	True	NA
5270	SERPINE2	False	True	Intrinsic Pathway of Fibrin Clot Formation;Common Pathway of Fibrin Clot Formation;Dissolution of Fibrin Clot
5275	SERPINB13	True	True	RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
5277	PIGA	False	True	Synthesis of glycosylphosphatidylinositol (GPI)
5284	NA	True	False	Neutrophil degranulation
5286	PIK3C2A	False	True	Synthesis of PIPs at the plasma membrane;Synthesis of PIPs at the Golgi membrane;Synthesis of PIPs at the early endosome membrane;Synthesis of PIPs at the late endosome membrane;Golgi Associated Vesicle Biogenesis;Clathrin-mediated endocytosis
5287	PIK3C2B	False	True	Synthesis of PIPs at the plasma membrane
5289	PIK3C3	False	True	PI3K Cascade;Macroautophagy;Synthesis of PIPs at the Golgi membrane;Synthesis of PIPs at the early endosome membrane;Synthesis of PIPs at the late endosome membrane;Toll Like Receptor 9 (TLR9) Cascade;RHO GTPases Activate NADPH Oxidases
5290	PIK3CA	False	True	PI3K Cascade;IRS-mediated signalling;GPVI-mediated activation cascade;Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants;PI3K events in ERBB4 signaling;PIP3 activates AKT signaling;Signaling by SCF-KIT;Synthesis of PIPs at the plasma membrane;GAB1 signalosome;Signaling by cytosolic FGFR1 fusion mutants;Downstream signal transduction;PI3K events in ERBB2 signaling;PI3K/AKT activation;Downstream TCR signaling;Role of phospholipids in phagocytosis;Tie2 Signaling;Constitutive Signaling by Aberrant PI3K in Cancer;DAP12 signaling;Role of LAT2/NTAL/LAB on calcium mobilization;Nephrin family interactions;Costimulation by the CD28 family;CD28 dependent PI3K/Akt signaling;G alpha (q) signalling events;VEGFA-VEGFR2 Pathway;VEGFA-VEGFR2 Pathway;Interleukin-3, Interleukin-5 and GM-CSF signaling;Constitutive Signaling by EGFRvIII;PI-3K cascade:FGFR1;PI-3K cascade:FGFR2;PI-3K cascade:FGFR3;PI-3K cascade:FGFR4;Signaling by FGFR2 in disease;Signaling by FGFR4 in disease;Signaling by FGFR1 in disease;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;MET activates PI3K/AKT signaling;Signaling by FGFR3 fusions in cancer;Signaling by FGFR3 point mutants in cancer;RET signaling;Erythropoietin activates Phosphoinositide-3-kinase (PI3K);Erythropoietin activates Phosphoinositide-3-kinase (PI3K);Activated NTRK2 signals through PI3K;Interleukin receptor SHC signaling;Regulation of signaling by CBL;Regulation of signaling by CBL;Activated NTRK3 signals through PI3K
5292	PIM1	False	True	Interleukin-4 and Interleukin-13 signaling
5296	PIK3R2	False	True	PI3K Cascade;IRS-mediated signalling;GPVI-mediated activation cascade;PIP3 activates AKT signaling;Interleukin-7 signaling;Interleukin-7 signaling;Signaling by SCF-KIT;Synthesis of PIPs at the plasma membrane;Downstream signal transduction;Rho GTPase cycle;PI3K/AKT activation;Downstream TCR signaling;Role of phospholipids in phagocytosis;Tie2 Signaling;Constitutive Signaling by Aberrant PI3K in Cancer;DAP12 signaling;Role of LAT2/NTAL/LAB on calcium mobilization;Nephrin family interactions;Costimulation by the CD28 family;CD28 dependent PI3K/Akt signaling;G alpha (q) signalling events;VEGFA-VEGFR2 Pathway;VEGFA-VEGFR2 Pathway;Interleukin-3, Interleukin-5 and GM-CSF signaling;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;RET signaling;Interleukin receptor SHC signaling;Regulation of signaling by CBL;Regulation of signaling by CBL
5298	PI4KB	False	True	Synthesis of PIPs at the Golgi membrane
5300	PIN1	False	True	ISG15 antiviral mechanism;RHO GTPases Activate NADPH Oxidases;Regulation of TP53 Activity through Phosphorylation;PI5P Regulates TP53 Acetylation;Negative regulators of DDX58/IFIH1 signaling
5304	NA	True	False	Miscellaneous transport and binding events
5306	PITPNA	False	True	Role of second messengers in netrin-1 signaling;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
5311	PKD2	False	True	VxPx cargo-targeting to cilium;VxPx cargo-targeting to cilium
5315	PKM	True	True	Neutrophil degranulation;Glycolysis
5317	PKP1	False	True	Apoptotic cleavage of cell adhesion  proteins;Neutrophil degranulation;Keratinization;Formation of the cornified envelope
5318	PKP2	False	True	Keratinization;Formation of the cornified envelope
5321	PLA2G4A	False	True	phospho-PLA2 pathway;Acyl chain remodelling of PC;Acyl chain remodeling of CL;Acyl chain remodelling of PS;Acyl chain remodelling of PE;Acyl chain remodelling of PI;Acyl chain remodelling of PG;Hydrolysis of LPC;Synthesis of PA;Arachidonic acid metabolism;ADP signalling through P2Y purinoceptor 1;Platelet sensitization by LDL;COPI-independent Golgi-to-ER retrograde traffic
5324	NA	False	True	NA
5327	PLAT	False	True	Signaling by PDGF;Dissolution of Fibrin Clot
5339	PLEC	True	True	Assembly of collagen fibrils and other multimeric structures;Caspase-mediated cleavage of cytoskeletal proteins;Type I hemidesmosome assembly
5340	PLG	False	True	Platelet degranulation ;Degradation of the extracellular matrix;Degradation of the extracellular matrix;Activation of Matrix Metalloproteinases;Signaling by PDGF;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Dissolution of Fibrin Clot
5347	PLK1	False	True	Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal;Polo-like kinase mediated events;Golgi Cisternae Pericentriolar Stack Reorganization;Golgi Cisternae Pericentriolar Stack Reorganization;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Phosphorylation of the APC/C;Phosphorylation of Emi1;Condensation of Prophase Chromosomes;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;Regulation of PLK1 Activity at G2/M Transition;Activation of NIMA Kinases NEK9, NEK6, NEK7;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;RHO GTPases Activate Formins;Mitotic Prometaphase;Mitotic Metaphase/Anaphase Transition;Mitotic Telophase/Cytokinesis;Cyclin A/B1/B2 associated events during G2/M transition;The role of GTSE1 in G2/M progression after G2 checkpoint;AURKA Activation by TPX2
5349	FXYD3	False	True	Ion homeostasis;Ion transport by P-type ATPases
5354	PLP1	False	True	NA
5355	PLP2	False	True	NA
5357	NA	False	True	NA
5371	PML	False	True	SUMOylation of DNA damage response and repair proteins;SUMOylation of ubiquitinylation proteins;Regulation of TP53 Activity through Acetylation;Interferon gamma signaling;Regulation of RUNX1 Expression and Activity;Regulation of PTEN localization
5375	PMP2	False	True	NA
5376	PMP22	False	True	NA
5395	PMS2	False	True	Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha);Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta);Defective Mismatch Repair Associated With MLH1;Defective Mismatch Repair Associated With PMS2;TP53 Regulates Transcription of DNA Repair Genes
5406	PNLIP	False	True	Digestion of dietary lipid;Retinoid metabolism and transport
5407	PNLIPRP1	False	True	Digestion of dietary lipid
5422	POLA1	False	True	Inhibition of replication initiation of damaged DNA by RB1/E2F1;Polymerase switching on the C-strand of the telomere;Telomere C-strand synthesis initiation;Activation of E2F1 target genes at G1/S;DNA replication initiation;Activation of the pre-replicative complex;Polymerase switching;Removal of the Flap Intermediate;Processive synthesis on the lagging strand
5427	POLE2	False	True	Recognition of DNA damage by PCNA-containing replication complex;Telomere C-strand synthesis initiation;PCNA-Dependent Long Patch Base Excision Repair;Termination of translesion DNA synthesis;HDR through Homologous Recombination (HRR);Gap-filling DNA repair synthesis and ligation in GG-NER;Dual Incision in GG-NER;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;DNA replication initiation;Activation of the pre-replicative complex
5429	POLH	False	True	Translesion Synthesis by POLH;Termination of translesion DNA synthesis;HDR through Homologous Recombination (HRR)
5433	POLR2D	False	True	Formation of RNA Pol II elongation complex ;Formation of the Early Elongation Complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of the HIV-1 Early Elongation Complex;RNA Pol II CTD phosphorylation and interaction with CE during HIV infection;HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;Formation of HIV-1 elongation complex containing HIV-1 Tat;Formation of HIV-1 elongation complex containing HIV-1 Tat;Pausing and recovery of Tat-mediated HIV elongation;Abortive elongation of HIV-1 transcript in the absence of Tat;Tat-mediated HIV elongation arrest and recovery;Tat-mediated elongation of the HIV-1 transcript;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;Viral Messenger RNA Synthesis;MicroRNA (miRNA) biogenesis;Transcriptional regulation of pluripotent stem cells;Transcriptional regulation by small RNAs;PIWI-interacting RNA (piRNA) biogenesis;Activation of anterior HOX genes in hindbrain development during early embryogenesis;RNA Polymerase II Pre-transcription Events;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;TP53 Regulates Transcription of DNA Repair Genes;FGFR2 alternative splicing;RNA polymerase II transcribes snRNA genes;RNA polymerase II transcribes snRNA genes;mRNA Capping;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;Processing of Capped Intron-Containing Pre-mRNA;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Elongation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Pol II CTD phosphorylation and interaction with CE;Signaling by FGFR2 IIIa TM;Estrogen-dependent gene expression
5434	POLR2E	False	True	Formation of RNA Pol II elongation complex ;Formation of the Early Elongation Complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of the HIV-1 Early Elongation Complex;RNA Pol II CTD phosphorylation and interaction with CE during HIV infection;HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;Formation of HIV-1 elongation complex containing HIV-1 Tat;Formation of HIV-1 elongation complex containing HIV-1 Tat;Pausing and recovery of Tat-mediated HIV elongation;Abortive elongation of HIV-1 transcript in the absence of Tat;Tat-mediated HIV elongation arrest and recovery;Tat-mediated elongation of the HIV-1 transcript;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;Viral Messenger RNA Synthesis;Cytosolic sensors of pathogen-associated DNA ;MicroRNA (miRNA) biogenesis;NoRC negatively regulates rRNA expression;Transcriptional regulation of pluripotent stem cells;B-WICH complex positively regulates rRNA expression;Transcriptional regulation by small RNAs;PIWI-interacting RNA (piRNA) biogenesis;Activation of anterior HOX genes in hindbrain development during early embryogenesis;RNA Polymerase II Pre-transcription Events;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;TP53 Regulates Transcription of DNA Repair Genes;FGFR2 alternative splicing;RNA polymerase II transcribes snRNA genes;RNA polymerase II transcribes snRNA genes;mRNA Capping;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;Processing of Capped Intron-Containing Pre-mRNA;RNA Polymerase I Transcription Initiation;RNA Polymerase I Transcription Initiation;RNA Polymerase I Promoter Escape;RNA Polymerase II Promoter Escape;RNA Polymerase I Chain Elongation;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase III Chain Elongation;RNA Polymerase I Transcription Termination;RNA Polymerase III Transcription Termination;RNA Polymerase III Abortive And Retractive Initiation;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Elongation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Polymerase III Transcription Initiation From Type 1 Promoter;RNA Polymerase III Transcription Initiation From Type 1 Promoter;RNA Polymerase III Transcription Initiation From Type 2 Promoter;RNA Polymerase III Transcription Initiation From Type 2 Promoter;RNA Polymerase III Transcription Initiation From Type 3 Promoter;RNA Polymerase III Transcription Initiation From Type 3 Promoter;RNA Pol II CTD phosphorylation and interaction with CE;Signaling by FGFR2 IIIa TM;Estrogen-dependent gene expression
5451	POU2F1	False	True	Interleukin-4 and Interleukin-13 signaling;RNA polymerase II transcribes snRNA genes;RNA polymerase II transcribes snRNA genes;RNA Polymerase III Abortive And Retractive Initiation;RNA Polymerase III Transcription Initiation From Type 3 Promoter;RNA Polymerase III Transcription Initiation From Type 3 Promoter;Estrogen-dependent gene expression
5464	PPA1	False	True	Cytosolic tRNA aminoacylation;Pyrophosphate hydrolysis
5465	PPARA	False	True	RORA activates gene expression;BMAL1:CLOCK,NPAS2 activates circadian gene expression;PPARA activates gene expression;PPARA activates gene expression;Transcriptional activation of mitochondrial biogenesis;Activation of gene expression by SREBF (SREBP);Transcriptional regulation of white adipocyte differentiation;Nuclear Receptor transcription pathway;Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha);Circadian Clock;SUMOylation of intracellular receptors
5467	PPARD	False	True	Import of palmitoyl-CoA into the mitochondrial matrix;Regulation of pyruvate dehydrogenase (PDH) complex;Nuclear Receptor transcription pathway;Signaling by Retinoic Acid
5473	PPBP	False	True	Platelet degranulation ;Chemokine receptors bind chemokines;G alpha (i) signalling events;Neutrophil degranulation
5476	CTSA	False	True	Glycosphingolipid metabolism;MHC class II antigen presentation;Sialic acid metabolism;Neutrophil degranulation
5478	PPIA	True	True	Platelet degranulation ;Uncoating of the HIV Virion;Budding and maturation of HIV virion;Integration of provirus;Early Phase of HIV Life Cycle;Minus-strand DNA synthesis;Plus-strand DNA synthesis;Binding and entry of HIV virion;Assembly Of The HIV Virion;APOBEC3G mediated resistance to HIV-1 infection;Calcineurin activates NFAT;Basigin interactions;Neutrophil degranulation;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
5479	PPIB	True	True	Collagen biosynthesis and modifying enzymes
5481	PPID	False	True	ESR-mediated signaling
5494	PPM1A	False	True	Downregulation of SMAD2/3:SMAD4 transcriptional activity;Energy dependent regulation of mTOR by LKB1-AMPK
5495	PPM1B	False	True	ISG15 antiviral mechanism
5496	PPM1G	False	True	NA
5499	PPP1CA	False	True	Triglyceride catabolism;DARPP-32 events;Downregulation of TGF-beta receptor signaling;Circadian Clock
5500	PPP1CB	False	True	Triglyceride catabolism;Downregulation of TGF-beta receptor signaling;Regulation of PLK1 Activity at G2/M Transition;Circadian Clock;RHO GTPases activate PKNs;RHO GTPases activate PKNs;RHO GTPases activate CIT;RHO GTPases Activate ROCKs;RHO GTPases activate PAKs;RHO GTPases activate PAKs
5501	PPP1CC	False	True	Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal;Triglyceride catabolism;Downregulation of TGF-beta receptor signaling;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;Circadian Clock;RHO GTPases Activate Formins;Mitotic Prometaphase
5504	PPP1R2	False	True	NA
5509	PPP1R3D	False	True	NA
5511	PPP1R8	False	True	NA
5515	PPP2CA	False	True	Inhibition of replication initiation of damaged DNA by RB1/E2F1;Spry regulation of FGF signaling;Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal;Integration of energy metabolism;PP2A-mediated dephosphorylation of key metabolic factors;DARPP-32 events;Degradation of beta-catenin by the destruction complex;Beta-catenin phosphorylation cascade;ERK/MAPK targets;ERKs are inactivated;MASTL Facilitates Mitotic Progression;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;Initiation of Nuclear Envelope Reformation;CTLA4 inhibitory signaling;Platelet sensitization by LDL;Disassembly of the destruction complex and recruitment of AXIN to the membrane;Disassembly of the destruction complex and recruitment of AXIN to the membrane;Misspliced GSK3beta mutants stabilize beta-catenin;S33 mutants of beta-catenin aren't phosphorylated;S37 mutants of beta-catenin aren't phosphorylated;S45 mutants of beta-catenin aren't phosphorylated;T41 mutants of beta-catenin aren't phosphorylated;APC truncation mutants have impaired AXIN binding;AXIN missense mutants destabilize the destruction complex;Truncations of AMER1 destabilize the destruction complex;RHO GTPases Activate Formins;RAF activation;Negative regulation of MAPK pathway;Regulation of TP53 Degradation;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Mitotic Prometaphase;Cyclin D associated events in G1;Cyclin A/B1/B2 associated events during G2/M transition;Glycolysis;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
5518	PPP2R1A	False	True	Inhibition of replication initiation of damaged DNA by RB1/E2F1;Spry regulation of FGF signaling;Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal;Integration of energy metabolism;PP2A-mediated dephosphorylation of key metabolic factors;DARPP-32 events;Degradation of beta-catenin by the destruction complex;Beta-catenin phosphorylation cascade;ERK/MAPK targets;ERKs are inactivated;MASTL Facilitates Mitotic Progression;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;Regulation of PLK1 Activity at G2/M Transition;Initiation of Nuclear Envelope Reformation;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;CTLA4 inhibitory signaling;Platelet sensitization by LDL;Disassembly of the destruction complex and recruitment of AXIN to the membrane;Disassembly of the destruction complex and recruitment of AXIN to the membrane;Misspliced GSK3beta mutants stabilize beta-catenin;S33 mutants of beta-catenin aren't phosphorylated;S37 mutants of beta-catenin aren't phosphorylated;S45 mutants of beta-catenin aren't phosphorylated;T41 mutants of beta-catenin aren't phosphorylated;APC truncation mutants have impaired AXIN binding;AXIN missense mutants destabilize the destruction complex;Truncations of AMER1 destabilize the destruction complex;Anchoring of the basal body to the plasma membrane;RHO GTPases Activate Formins;RAF activation;Negative regulation of MAPK pathway;Regulation of TP53 Degradation;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Mitotic Prometaphase;Cyclin D associated events in G1;Cyclin A/B1/B2 associated events during G2/M transition;Glycolysis;AURKA Activation by TPX2;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
5520	PPP2R2A	False	True	Initiation of Nuclear Envelope Reformation;Cyclin D associated events in G1;Cyclin A/B1/B2 associated events during G2/M transition;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
5530	PPP3CA	False	True	DARPP-32 events;Calcineurin activates NFAT;Calcineurin activates NFAT;FCERI mediated Ca+2 mobilization;Ca2+ pathway;CLEC7A (Dectin-1) induces NFAT activation
5534	PPP3R1	False	True	Activation of BAD and translocation to mitochondria ;DARPP-32 events;Calcineurin activates NFAT;Calcineurin activates NFAT;FCERI mediated Ca+2 mobilization;Ca2+ pathway;CLEC7A (Dectin-1) induces NFAT activation
5536	PPP5C	False	True	Negative regulation of MAPK pathway;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;ESR-mediated signaling
5538	PPT1	False	True	Fatty acyl-CoA biosynthesis
5546	PRCC	False	True	mRNA Splicing - Major Pathway
5547	PRCP	False	True	Intrinsic Pathway of Fibrin Clot Formation;Neutrophil degranulation
5550	PREP	False	True	NA
5562	PRKAA1	False	True	Macroautophagy;Energy dependent regulation of mTOR by LKB1-AMPK;TP53 Regulates Metabolic Genes;Regulation of TP53 Activity through Phosphorylation;Activation of AMPK downstream of NMDARs
5563	PRKAA2	False	True	Translocation of SLC2A4 (GLUT4) to the plasma membrane;Macroautophagy;AMPK inhibits chREBP transcriptional activation activity;AMPK inhibits chREBP transcriptional activation activity;Import of palmitoyl-CoA into the mitochondrial matrix;Activation of PPARGC1A (PGC-1alpha) by phosphorylation;Energy dependent regulation of mTOR by LKB1-AMPK;TP53 Regulates Metabolic Genes;Regulation of TP53 Activity through Phosphorylation;Activation of AMPK downstream of NMDARs
5567	PRKACB	False	True	PKA-mediated phosphorylation of CREB;PKA-mediated phosphorylation of key metabolic factors;Triglyceride catabolism;PKA activation;PKA activation in glucagon signalling;DARPP-32 events;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Rap1 signalling;Regulation of insulin secretion;Vasopressin regulates renal water homeostasis via Aquaporins;VEGFA-VEGFR2 Pathway;CREB1 phosphorylation through the activation of Adenylate Cyclase;CREB1 phosphorylation through the activation of Adenylate Cyclase;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'off' state;CD209 (DC-SIGN) signaling;MAPK6/MAPK4 signaling;Glycolysis;RET signaling;HDL assembly;ROBO receptors bind AKAP5;Factors involved in megakaryocyte development and platelet production
5578	PRKCA	False	True	Calmodulin induced events;Disinhibition of SNARE formation;SHC1 events in ERBB2 signaling;Signaling by SCF-KIT;Regulation of KIT signaling;EGFR Transactivation by Gastrin;Inactivation, recovery and regulation of the phototransduction cascade;Syndecan interactions;Acetylcholine regulates insulin secretion;Ca2+ pathway;Trafficking of GluR2-containing AMPA receptors;G alpha (z) signalling events;Depolymerisation of the Nuclear Lamina;HuR (ELAVL1) binds and stabilizes mRNA;WNT5A-dependent internalization of FZD4;VEGFR2 mediated cell proliferation;RHO GTPases Activate NADPH Oxidases;Response to elevated platelet cytosolic Ca2+;RET signaling;ROBO receptors bind AKAP5;ROBO receptors bind AKAP5
5579	PRKCB	False	True	Disinhibition of SNARE formation;Activation of NF-kappaB in B cells;Trafficking of GluR2-containing AMPA receptors;G alpha (z) signalling events;Depolymerisation of the Nuclear Lamina;WNT5A-dependent internalization of FZD4;VEGFR2 mediated cell proliferation;RHO GTPases Activate NADPH Oxidases;Response to elevated platelet cytosolic Ca2+;RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
5580	PRKCD	False	True	Apoptotic cleavage of cellular proteins;Calmodulin induced events;Effects of PIP2 hydrolysis;SHC1 events in ERBB2 signaling;DAG and IP3 signaling;Role of phospholipids in phagocytosis;G alpha (z) signalling events;HuR (ELAVL1) binds and stabilizes mRNA;VEGFR2 mediated cell proliferation;CLEC7A (Dectin-1) signaling;RHO GTPases Activate NADPH Oxidases;Neutrophil degranulation;Interferon gamma signaling
5581	PRKCE	False	True	Effects of PIP2 hydrolysis;SHC1 events in ERBB2 signaling;DAG and IP3 signaling;Role of phospholipids in phagocytosis;G alpha (z) signalling events
5582	PRKCG	False	True	Calmodulin induced events;Disinhibition of SNARE formation;Trafficking of GluR2-containing AMPA receptors;G alpha (z) signalling events;WNT5A-dependent internalization of FZD4;Response to elevated platelet cytosolic Ca2+
5583	PRKCH	False	True	Effects of PIP2 hydrolysis;G alpha (z) signalling events
5584	PRKCI	False	True	Pre-NOTCH Transcription and Translation;p75NTR recruits signalling complexes;Tight junction interactions
5585	PKN1	False	True	RHO GTPases activate PKNs;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
5586	PKN2	False	True	RHO GTPases activate PKNs
5587	PRKD1	False	True	Sphingolipid de novo biosynthesis
5588	PRKCQ	False	True	Apoptotic cleavage of cellular proteins;Effects of PIP2 hydrolysis;Downstream TCR signaling;Inactivation, recovery and regulation of the phototransduction cascade;FCERI mediated NF-kB activation;FCERI mediated NF-kB activation;Netrin-1 signaling;G alpha (z) signalling events;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
5589	PRKCSH	False	True	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);N-glycan trimming in the ER and Calnexin/Calreticulin cycle;Advanced glycosylation endproduct receptor signaling;Post-translational protein phosphorylation;Calnexin/calreticulin cycle
5590	PRKCZ	False	True	GPVI-mediated activation cascade;TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);VEGFR2 mediated cell proliferation;RHO GTPases Activate NADPH Oxidases
5591	PRKDC	False	True	Cytosolic sensors of pathogen-associated DNA ;IRF3-mediated induction of type I IFN;Nonhomologous End-Joining (NHEJ);E3 ubiquitin ligases ubiquitinate target proteins
5593	PRKG2	False	True	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation;Ca2+ pathway;cGMP effects;cGMP effects
5594	MAPK1	False	True	phospho-PLA2 pathway;RAF-independent MAPK1/3 activation;MAPK1 (ERK2) activation;Spry regulation of FGF signaling;Golgi Cisternae Pericentriolar Stack Reorganization;Frs2-mediated activation;ERK/MAPK targets;ERK/MAPK targets;ERKs are inactivated;Regulation of actin dynamics for phagocytic cup formation;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);Oncogene Induced Senescence;Oncogene Induced Senescence;FCERI mediated MAPK activation;Regulation of HSF1-mediated heat shock response;NCAM signaling for neurite out-growth;Recycling pathway of L1;RSK activation;Signal transduction by L1;Activation of the AP-1 family of transcription factors;Thrombin signalling through proteinase activated receptors (PARs);Negative regulation of FGFR1 signaling;Negative regulation of FGFR2 signaling;Negative regulation of FGFR3 signaling;Negative regulation of FGFR4 signaling;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate NADPH Oxidases;RAF/MAP kinase cascade;MAP2K and MAPK activation;Negative feedback regulation of MAPK pathway;Negative regulation of MAPK pathway;Neutrophil degranulation;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Signal attenuation;Advanced glycosylation endproduct receptor signaling;Gastrin-CREB signalling pathway via PKC and MAPK;ESR-mediated signaling;RUNX2 regulates osteoblast differentiation;Regulation of PTEN gene transcription;Regulation of the apoptosome activity;Growth hormone receptor signaling
5596	MAPK4	False	True	MAPK6/MAPK4 signaling
5598	MAPK7	False	True	ERK/MAPK targets;ERK/MAPK targets;Signalling to ERK5;Signalling to ERK5;ERKs are inactivated;Senescence-Associated Secretory Phenotype (SASP);Gastrin-CREB signalling pathway via PKC and MAPK;RET signaling
5599	MAPK8	False	True	Activation of BIM and translocation to mitochondria ;Activation of BMF and translocation to mitochondria;NRAGE signals death through JNK;NRAGE signals death through JNK;NRIF signals cell death from the nucleus;Oxidative Stress Induced Senescence;FCERI mediated MAPK activation;DSCAM interactions;JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1;Activation of the AP-1 family of transcription factors;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Interleukin-38 signaling
5602	MAPK10	False	True	Oxidative Stress Induced Senescence;FCERI mediated MAPK activation;JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1;Activation of the AP-1 family of transcription factors
5604	MAP2K1	False	True	MAPK3 (ERK1) activation;Signal transduction by L1;Uptake and function of anthrax toxins;RAF activation;MAP2K and MAPK activation;Negative feedback regulation of MAPK pathway;MAP3K8 (TPL2)-dependent MAPK1/3 activation;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF
5605	MAP2K2	False	True	MAPK1 (ERK2) activation;Signal transduction by L1;Uptake and function of anthrax toxins;RAF activation;MAP2K and MAPK activation;Negative feedback regulation of MAPK pathway;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF
5606	MAP2K3	False	True	Oxidative Stress Induced Senescence;activated TAK1 mediates p38 MAPK activation;Uptake and function of anthrax toxins
5607	MAP2K5	False	True	Signalling to ERK5
5609	MAP2K7	False	True	Oxidative Stress Induced Senescence;FCERI mediated MAPK activation;JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1;Uptake and function of anthrax toxins
5610	EIF2AK2	False	True	ISG15 antiviral mechanism;Inhibition of PKR
5613	PRKX	False	True	PKA-mediated phosphorylation of CREB;CREB1 phosphorylation through the activation of Adenylate Cyclase
5616	PRKY	False	True	NA
5621	PRNP	False	True	NCAM1 interactions
5630	PRPH	False	True	NA
5631	PRPS1	False	True	5-Phosphoribose 1-diphosphate biosynthesis
5635	PRPSAP1	False	True	NA
5636	PRPSAP2	False	True	NA
5641	LGMN	False	True	Trafficking and processing of endosomal TLR;Vitamin D (calciferol) metabolism;MHC class II antigen presentation
5644	PRSS1	False	True	Activation of Matrix Metalloproteinases;Cobalamin (Cbl, vitamin B12) transport and metabolism
5646	PRSS3	False	True	Alpha-defensins;Cobalamin (Cbl, vitamin B12) transport and metabolism;Neutrophil degranulation;Antimicrobial peptides
5660	PSAP	False	True	Platelet degranulation ;Glycosphingolipid metabolism;Peptide ligand-binding receptors;G alpha (i) signalling events;Neutrophil degranulation
5663	PSEN1	False	True	Nuclear signaling by ERBB4;Degradation of the extracellular matrix;Regulated proteolysis of p75NTR;NRIF signals cell death from the nucleus;Activated NOTCH1 Transmits Signal to the Nucleus;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;NOTCH2 Activation and Transmission of Signal to the Nucleus;EPH-ephrin mediated repulsion of cells;Neutrophil degranulation;NOTCH3 Activation and Transmission of Signal to the Nucleus;NOTCH4 Activation and Transmission of Signal to the Nucleus;Noncanonical activation of NOTCH3
5664	PSEN2	False	True	Nuclear signaling by ERBB4;Regulated proteolysis of p75NTR;NRIF signals cell death from the nucleus;Activated NOTCH1 Transmits Signal to the Nucleus;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;NOTCH2 Activation and Transmission of Signal to the Nucleus;EPH-ephrin mediated repulsion of cells;NOTCH3 Activation and Transmission of Signal to the Nucleus;NOTCH4 Activation and Transmission of Signal to the Nucleus;Noncanonical activation of NOTCH3
5681	PSKH1	False	True	NA
5682	PSMA1	False	True	Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation
5683	PSMA2	False	True	Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation
5684	PSMA3	True	True	Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation
5685	PSMA4	False	True	Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation
5686	PSMA5	False	True	Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation
5687	PSMA6	False	True	Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation
5688	PSMA7	False	True	Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation
5689	PSMB1	False	True	Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation
5690	PSMB2	False	True	Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation
5691	PSMB3	True	True	Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation
5692	PSMB4	False	True	Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation
5693	PSMB5	False	True	Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation
5694	PSMB6	False	True	Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation
5695	PSMB7	False	True	Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation
5696	PSMB8	False	True	Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Interferon alpha/beta signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation
5698	PSMB9	False	True	Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation
5699	PSMB10	False	True	Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation
5700	PSMC1	False	True	Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;N-glycan trimming in the ER and Calnexin/Calreticulin cycle;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation
5701	PSMC2	False	True	Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation
5702	PSMC3	False	True	Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation
5704	PSMC4	False	True	Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation
5705	PSMC5	False	True	Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation
5706	PSMC6	False	True	Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation
5707	PSMD1	False	True	Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation
5708	PSMD2	False	True	Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation
5709	PSMD3	False	True	Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation
5710	PSMD4	False	True	Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation
5711	PSMD5	False	True	Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation
5713	PSMD7	False	True	Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation
5714	PSMD8	False	True	Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation
5717	PSMD11	False	True	Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation
5718	PSMD12	False	True	Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation
5719	PSMD13	False	True	Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation
5720	PSME1	False	True	Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation
5721	PSME2	False	True	Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation
5725	PTBP1	False	True	FGFR2 alternative splicing;mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA
5728	PTEN	False	True	Synthesis of PIPs at the plasma membrane;Synthesis of IP3 and IP4 in the cytosol;Negative regulation of the PI3K/AKT network;Downstream TCR signaling;TP53 Regulates Metabolic Genes;PTEN Loss of Function in Cancer;Ub-specific processing proteases;Ovarian tumor domain proteases;Regulation of PTEN mRNA translation;Regulation of PTEN localization;Regulation of PTEN stability and activity;Transcriptional Regulation by MECP2
5730	PTGDS	False	True	Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
5747	PTK2	False	True	Apoptotic cleavage of cellular proteins;Regulation of actin dynamics for phagocytic cup formation;Integrin alphaIIb beta3 signaling;GRB2:SOS provides linkage to MAPK signaling for Integrins ;p130Cas linkage to MAPK signaling for integrins;NCAM signaling for neurite out-growth;NCAM signaling for neurite out-growth;Signal regulatory protein family interactions;EPHB-mediated forward signaling;EPHB-mediated forward signaling;DCC mediated attractive signaling;DCC mediated attractive signaling;VEGFA-VEGFR2 Pathway;VEGFA-VEGFR2 Pathway;RHO GTPases Activate WASPs and WAVEs;RAF/MAP kinase cascade;MET activates PTK2 signaling
5753	PTK6	False	True	SCF(Skp2)-mediated degradation of p27/p21;Cyclin D associated events in G1;ERBB2 Activates PTK6 Signaling;PTK6 Regulates Proteins Involved in RNA Processing;PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1;PTK6 Regulates Cell Cycle;PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases;PTK6 Down-Regulation;PTK6 Expression;PTK6 Activates STAT3;PTK6 promotes HIF1A stabilization
5756	TWF1	False	True	NA
5757	PTMA	False	True	NA
5763	PTMS	False	True	NA
5764	PTN	False	True	NA
5768	QSOX1	False	True	Platelet degranulation ;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Neutrophil degranulation;Post-translational protein phosphorylation
5770	PTPN1	False	True	Integrin alphaIIb beta3 signaling;Negative regulation of MET activity;Regulation of IFNG signaling;PTK6 Down-Regulation;MECP2 regulates neuronal receptors and channels;Regulation of IFNA signaling;Growth hormone receptor signaling;Growth hormone receptor signaling
5771	PTPN2	False	True	Negative regulation of MET activity;Regulation of IFNG signaling;Interleukin-37 signaling
5774	PTPN3	False	True	EGFR downregulation
5777	PTPN6	False	True	GPVI-mediated activation cascade;Regulation of KIT signaling;PECAM1 interactions;Costimulation by the CD28 family;PD-1 signaling;Signal regulatory protein family interactions;Platelet sensitization by LDL;Interleukin-3, Interleukin-5 and GM-CSF signaling;CD22 mediated BCR regulation;Neutrophil degranulation;Interferon gamma signaling;Regulation of IFNG signaling;Interleukin-37 signaling;Interferon alpha/beta signaling;Interleukin receptor SHC signaling;Regulation of IFNA signaling;Growth hormone receptor signaling;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
5780	PTPN9	False	True	Interleukin-37 signaling
5782	PTPN12	False	True	SHC1 events in ERBB2 signaling;SHC1 events in ERBB2 signaling;EGFR downregulation;Signaling by PDGF;Downregulation of ERBB2 signaling;Interleukin-37 signaling
5784	PTPN14	False	True	Interleukin-37 signaling
5786	PTPRA	False	True	NCAM signaling for neurite out-growth;NCAM signaling for neurite out-growth;RAF/MAP kinase cascade
5793	PTPRG	False	True	NA
5814	PURB	False	True	NA
5819	PVRL2	False	True	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Adherens junctions interactions;Nectin/Necl  trans heterodimerization
5824	PEX19	False	True	ABC transporters in lipid homeostasis
5829	PXN	False	True	GAB1 signalosome;VEGFA-VEGFR2 Pathway;Smooth Muscle Contraction;Localization of the PINCH-ILK-PARVIN complex to focal adhesions;Regulation of cytoskeletal remodeling and cell spreading by IPP complex components;PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
5830	PEX5	False	True	E3 ubiquitin ligases ubiquitinate target proteins;Peroxisomal protein import;Peroxisomal protein import
5859	QARS	False	True	SeMet incorporation into proteins;Cytosolic tRNA aminoacylation;Mitochondrial tRNA aminoacylation
5860	QDPR	False	True	Phenylalanine and tyrosine catabolism
5861	RAB1A	False	True	Golgi Cisternae Pericentriolar Stack Reorganization;Golgi Cisternae Pericentriolar Stack Reorganization;COPII-mediated vesicle transport;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;RAB geranylgeranylation;RAB GEFs exchange GTP for GDP on RABs
5862	RAB2A	False	True	Golgi Cisternae Pericentriolar Stack Reorganization;RAB geranylgeranylation
5866	RAB3IL1	False	True	RAB GEFs exchange GTP for GDP on RABs
5867	RAB4A	False	True	Translocation of SLC2A4 (GLUT4) to the plasma membrane;Synthesis of PIPs at the plasma membrane;TBC/RABGAPs;RAB geranylgeranylation;MET receptor recycling
5868	RAB5A	False	True	Synthesis of PIPs at the plasma membrane;TBC/RABGAPs;Clathrin-mediated endocytosis;RAB geranylgeranylation;RAB GEFs exchange GTP for GDP on RABs;Factors involved in megakaryocyte development and platelet production
5869	RAB5B	False	True	Neutrophil degranulation;TBC/RABGAPs;Clathrin-mediated endocytosis;RAB geranylgeranylation;RAB GEFs exchange GTP for GDP on RABs
5871	MAP4K2	False	True	NA
5879	RAC1	False	True	GPVI-mediated activation cascade;PIP3 activates AKT signaling;Signaling by SCF-KIT;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Nef and signal transduction;NRAGE signals death through JNK;Rho GTPase cycle;Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;Constitutive Signaling by Aberrant PI3K in Cancer;DAP12 signaling;FCERI mediated MAPK activation;DSCAM interactions;CD28 dependent Vav1 pathway;EPHB-mediated forward signaling;Ephrin signaling;EPH-ephrin mediated repulsion of cells;Sema3A PAK dependent Axon repulsion;SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion;PCP/CE pathway;Sema4D mediated inhibition of cell attachment and migration;DCC mediated attractive signaling;DCC mediated attractive signaling;Activation of RAC1;Inactivation of CDC42 and RAC1;VEGFA-VEGFR2 Pathway;Signal transduction by L1;VEGFR2 mediated vascular permeability;RHO GTPases activate PKNs;RHO GTPases activate CIT;RHO GTPases activate CIT;RHO GTPases activate KTN1;RHO GTPases activate IQGAPs;RHO GTPases activate PAKs;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate Formins;RHO GTPases Activate Formins;RHO GTPases Activate NADPH Oxidases;MAPK6/MAPK4 signaling;Neutrophil degranulation;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases;MET activates RAP1 and RAC1;NTRK2 activates RAC1;Activated NTRK2 signals through CDK5;Activation of RAC1 downstream of NMDARs;Factors involved in megakaryocyte development and platelet production
5885	RAD21	False	True	Meiotic synapsis;Separation of Sister Chromatids;Establishment of Sister Chromatid Cohesion;Cohesin Loading onto Chromatin;Resolution of Sister Chromatid Cohesion;SUMOylation of DNA damage response and repair proteins;Estrogen-dependent gene expression
5886	RAD23A	False	True	Josephin domain DUBs;DNA Damage Recognition in GG-NER;Formation of Incision Complex in GG-NER
5887	RAD23B	False	True	N-glycan trimming in the ER and Calnexin/Calreticulin cycle;Josephin domain DUBs;DNA Damage Recognition in GG-NER;Formation of Incision Complex in GG-NER
5892	RAD51D	False	True	HDR through Homologous Recombination (HRR);Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA);Resolution of D-loop Structures through Holliday Junction Intermediates;Homologous DNA Pairing and Strand Exchange;Presynaptic phase of homologous DNA pairing and strand exchange;TP53 Regulates Transcription of DNA Repair Genes
5894	RAF1	False	True	Stimuli-sensing channels;Rap1 signalling;GP1b-IX-V activation signalling;CD209 (DC-SIGN) signaling;RAF activation;MAP2K and MAPK activation;Negative feedback regulation of MAPK pathway;Negative regulation of MAPK pathway;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF
5896	RAG1	False	True	Interleukin-7 signaling;MAPK6/MAPK4 signaling
5898	RALA	False	True	Translocation of SLC2A4 (GLUT4) to the plasma membrane;Translocation of SLC2A4 (GLUT4) to the plasma membrane;p38MAPK events;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
5901	RAN	False	True	Rev-mediated nuclear export of HIV RNA;Regulation of cholesterol biosynthesis by SREBP (SREBF);NEP/NS2 Interacts with the Cellular Export Machinery;Nuclear import of Rev protein;MicroRNA (miRNA) biogenesis;Transcriptional regulation by small RNAs;tRNA processing in the nucleus
5903	RANBP2	False	True	ISG15 antiviral mechanism;Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Rev-mediated nuclear export of HIV RNA;Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Viral Messenger RNA Synthesis;NEP/NS2 Interacts with the Cellular Export Machinery;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;snRNP Assembly;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;SUMOylation of DNA damage response and repair proteins;SUMOylation of ubiquitinylation proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;SUMOylation of SUMOylation proteins;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins;Transcriptional regulation by small RNAs;RHO GTPases Activate Formins;tRNA processing in the nucleus;Mitotic Prometaphase
5905	RANGAP1	False	True	Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal;Rev-mediated nuclear export of HIV RNA;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;SUMOylation of DNA replication proteins;RHO GTPases Activate Formins;Mitotic Prometaphase
5906	RAP1A	False	True	Frs2-mediated activation;ARMS-mediated activation;ARMS-mediated activation;Integrin alphaIIb beta3 signaling;GRB2:SOS provides linkage to MAPK signaling for Integrins ;p130Cas linkage to MAPK signaling for integrins;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Rap1 signalling;MAP2K and MAPK activation;Neutrophil degranulation;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF;MET activates RAP1 and RAC1
5910	RAP1GDS1	False	True	NA
5913	RAPSN	False	True	NA
5914	RARA	False	True	Nuclear Receptor transcription pathway;SUMOylation of intracellular receptors;Signaling by Retinoic Acid;Activation of anterior HOX genes in hindbrain development during early embryogenesis
5917	RARS	False	True	SeMet incorporation into proteins;Cytosolic tRNA aminoacylation
5920	RARRES3	False	True	Acyl chain remodelling of PE
5925	RB1	False	True	Inhibition of replication initiation of damaged DNA by RB1/E2F1;Inhibition of replication initiation of damaged DNA by RB1/E2F1;Condensation of Prophase Chromosomes;Formation of Senescence-Associated Heterochromatin Foci (SAHF);Oncogene Induced Senescence;Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes;Cyclin E associated events during G1/S transition ;Cyclin D associated events in G1;Cyclin A:Cdk2-associated events at S phase entry;RUNX2 regulates osteoblast differentiation
5928	RBBP4	False	True	Transcription of E2F targets under negative control by DREAM complex;Transcription of E2F targets under negative control by DREAM complex;Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1;G0 and Early G1;Polo-like kinase mediated events;PRC2 methylates histones and DNA;Oxidative Stress Induced Senescence;HDACs deacetylate histones;PKMTs methylate histone lysines;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;Activation of E2F1 target genes at G1/S;Activation of anterior HOX genes in hindbrain development during early embryogenesis;Deposition of new CENPA-containing nucleosomes at the centromere;Regulation of TP53 Activity through Acetylation;Cyclin E associated events during G1/S transition ;Cyclin A:Cdk2-associated events at S phase entry;RNA Polymerase I Transcription Initiation;Regulation of PTEN gene transcription;Regulation of PTEN gene transcription;Transcriptional Regulation by E2F6
5929	RBBP5	False	True	Formation of the beta-catenin:TCF transactivating complex;PKMTs methylate histone lysines;Deactivation of the beta-catenin transactivating complex;Activation of anterior HOX genes in hindbrain development during early embryogenesis;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Neddylation
5936	RBM4	False	True	Circadian Clock
5937	RBMS1	False	True	NA
5939	RBMS2	False	True	NA
5940	RBMY1A1	False	True	NA
5954	RCN1	False	True	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation
5955	RCN2	False	True	NA
5962	RDX	False	True	Recycling pathway of L1;Recycling pathway of L1
5970	RELA	False	True	Activation of NF-kappaB in B cells;RIP-mediated NFkB activation via ZBP1;Regulated proteolysis of p75NTR;Downstream TCR signaling;NF-kB is activated and signals survival;Senescence-Associated Secretory Phenotype (SASP);FCERI mediated NF-kB activation;DEx/H-box helicases activate type I IFN and inflammatory cytokines production ;PKMTs methylate histone lysines;Transcriptional regulation of white adipocyte differentiation;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;Interleukin-1 processing;SUMOylation of immune response proteins;IkBA variant leads to EDA-ID;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;CD209 (DC-SIGN) signaling;CLEC7A/inflammasome pathway;The NLRP3 inflammasome;Interleukin-1 signaling;TRAF6 mediated NF-kB activation
5976	UPF1	False	True	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
5979	RET	False	True	RAF/MAP kinase cascade;RET signaling
5981	RFC1	False	True	Translesion synthesis by REV1;Recognition of DNA damage by PCNA-containing replication complex;Translesion Synthesis by POLH;Polymerase switching on the C-strand of the telomere;PCNA-Dependent Long Patch Base Excision Repair;Translesion synthesis by POLK;Translesion synthesis by POLI;Termination of translesion DNA synthesis;HDR through Homologous Recombination (HRR);Gap-filling DNA repair synthesis and ligation in GG-NER;Dual Incision in GG-NER;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Polymerase switching
5987	TRIM27	False	True	SUMOylation of ubiquitinylation proteins;Regulation of PTEN stability and activity
5998	RGS3	False	True	G alpha (q) signalling events;G alpha (i) signalling events
6000	RGS7	False	True	G alpha (i) signalling events;G alpha (i) signalling events;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
6005	RHAG	False	True	Erythrocytes take up carbon dioxide and release oxygen;Erythrocytes take up oxygen and release carbon dioxide;Rhesus glycoproteins mediate ammonium transport.;Defective RHAG causes regulator type Rh-null hemolytic anemia (RHN)
6009	RHEB	False	True	Macroautophagy;mTOR signalling;mTORC1-mediated signalling;Energy dependent regulation of mTOR by LKB1-AMPK;TP53 Regulates Metabolic Genes;Regulation of PTEN gene transcription
6018	NA	False	True	NA
6050	RNH1	False	True	NA
6059	ABCE1	False	True	OAS antiviral response;Interferon alpha/beta signaling
6100	RP9	False	True	NA
6117	RPA1	False	True	Translesion synthesis by REV1;Recognition of DNA damage by PCNA-containing replication complex;Translesion Synthesis by POLH;Removal of the Flap Intermediate from the C-strand;Activation of ATR in response to replication stress;SUMOylation of DNA damage response and repair proteins;Regulation of HSF1-mediated heat shock response;HSF1 activation;Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha);Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta);Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta);PCNA-Dependent Long Patch Base Excision Repair;Translesion synthesis by POLK;Translesion synthesis by POLI;Termination of translesion DNA synthesis;HDR through Single Strand Annealing (SSA);HDR through Homologous Recombination (HRR);Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;Formation of Incision Complex in GG-NER;Gap-filling DNA repair synthesis and ligation in GG-NER;Dual Incision in GG-NER;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Fanconi Anemia Pathway;Regulation of TP53 Activity through Phosphorylation;Activation of the pre-replicative complex;Removal of the Flap Intermediate;G2/M DNA damage checkpoint;Meiotic recombination
6118	RPA2	False	True	Translesion synthesis by REV1;Recognition of DNA damage by PCNA-containing replication complex;Translesion Synthesis by POLH;Removal of the Flap Intermediate from the C-strand;Activation of ATR in response to replication stress;Regulation of HSF1-mediated heat shock response;HSF1 activation;Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha);Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta);Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta);PCNA-Dependent Long Patch Base Excision Repair;Translesion synthesis by POLK;Translesion synthesis by POLI;Termination of translesion DNA synthesis;HDR through Single Strand Annealing (SSA);HDR through Homologous Recombination (HRR);Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;Formation of Incision Complex in GG-NER;Gap-filling DNA repair synthesis and ligation in GG-NER;Dual Incision in GG-NER;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Fanconi Anemia Pathway;Regulation of TP53 Activity through Phosphorylation;Activation of the pre-replicative complex;Removal of the Flap Intermediate;G2/M DNA damage checkpoint;Meiotic recombination
6119	RPA3	False	True	Translesion synthesis by REV1;Recognition of DNA damage by PCNA-containing replication complex;Translesion Synthesis by POLH;Removal of the Flap Intermediate from the C-strand;Activation of ATR in response to replication stress;Regulation of HSF1-mediated heat shock response;HSF1 activation;Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha);Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta);Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta);PCNA-Dependent Long Patch Base Excision Repair;Translesion synthesis by POLK;Translesion synthesis by POLI;Termination of translesion DNA synthesis;HDR through Single Strand Annealing (SSA);HDR through Homologous Recombination (HRR);Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;Formation of Incision Complex in GG-NER;Gap-filling DNA repair synthesis and ligation in GG-NER;Dual Incision in GG-NER;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Fanconi Anemia Pathway;Regulation of TP53 Activity through Phosphorylation;Activation of the pre-replicative complex;Removal of the Flap Intermediate;G2/M DNA damage checkpoint;Meiotic recombination
6120	RPE	False	True	Pentose phosphate pathway
6122	RPL3	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6124	RPL4	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6125	RPL5	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6128	RPL6	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6129	RPL7	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6130	RPL7A	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6132	RPL8	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6133	RPL9	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6134	RPL10	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6135	RPL11	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6136	RPL12	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6137	RPL13	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6138	RPL15	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6139	RPL17	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6141	RPL18	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6142	RPL18A	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6143	RPL19	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6144	RPL21	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6146	RPL22	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6147	RPL23A	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6152	RPL24	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6154	RPL26	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6155	RPL27	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6156	RPL30	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6157	RPL27A	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6158	RPL28	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6159	RPL29	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6160	RPL31	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6161	RPL32	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6164	RPL34	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6165	RPL35A	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6167	RPL37	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6168	RPL37A	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6169	RPL38	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6173	RPL36A	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6175	RPLP0	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6176	RPLP1	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6181	RPLP2	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6182	MRPL12	False	True	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation elongation;Mitochondrial translation termination
6183	MRPS12	False	True	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation elongation;Mitochondrial translation termination
6184	RPN1	False	True	SRP-dependent cotranslational protein targeting to membrane;Asparagine N-linked glycosylation
6185	RPN2	False	True	SRP-dependent cotranslational protein targeting to membrane;Asparagine N-linked glycosylation
6187	RPS2	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;RMTs methylate histone arginines;rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Protein methylation;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6188	RPS3	True	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6189	RPS3A	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6191	RPS4X	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6193	RPS5	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6194	RPS6	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;mTORC1-mediated signalling;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6195	RPS6KA1	False	True	ERK/MAPK targets;CREB phosphorylation;Senescence-Associated Secretory Phenotype (SASP);Senescence-Associated Secretory Phenotype (SASP);Recycling pathway of L1;CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling;RSK activation;RSK activation;Gastrin-CREB signalling pathway via PKC and MAPK
6196	RPS6KA2	False	True	ERK/MAPK targets;CREB phosphorylation;Senescence-Associated Secretory Phenotype (SASP);Senescence-Associated Secretory Phenotype (SASP);Recycling pathway of L1;CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling;RSK activation;RSK activation;Gastrin-CREB signalling pathway via PKC and MAPK
6197	RPS6KA3	False	True	ERK/MAPK targets;CREB phosphorylation;Senescence-Associated Secretory Phenotype (SASP);Senescence-Associated Secretory Phenotype (SASP);Recycling pathway of L1;CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling;RSK activation;RSK activation;Gastrin-CREB signalling pathway via PKC and MAPK
6198	RPS6KB1	False	True	mTORC1-mediated signalling
6199	RPS6KB2	False	True	AKT phosphorylates targets in the nucleus;Constitutive Signaling by AKT1 E17K in Cancer
6201	RPS7	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6202	RPS8	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6203	RPS9	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6204	RPS10	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6205	RPS11	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6206	RPS12	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6207	RPS13	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6208	RPS14	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6209	RPS15	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6210	RPS15A	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6217	RPS16	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6218	RPS17	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6222	RPS18	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6223	RPS19	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6224	RPS20	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6227	RPS21	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6228	RPS23	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6229	RPS24	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6230	RPS25	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6231	RPS26	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6232	RPS27	False	True	Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal;L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Major pathway of rRNA processing in the nucleolus and cytosol;Mitotic Prometaphase;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6233	RPS27A	False	True	Translesion synthesis by REV1;Recognition of DNA damage by PCNA-containing replication complex;Translesion Synthesis by POLH;Activation of NF-kappaB in B cells;ISG15 antiviral mechanism;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants;ER-Phagosome pathway;Downregulation of ERBB4 signaling;Spry regulation of FGF signaling;Downregulation of ERBB2:ERBB3 signaling;L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;Budding and maturation of HIV virion;NOD1/2 Signaling Pathway;TICAM1, RIP1-mediated IKK complex recruitment ;DDX58/IFIH1-mediated induction of interferon-alpha/beta;APC/C:Cdc20 mediated degradation of Cyclin B;Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Membrane binding and targetting of GAG proteins;Assembly Of The HIV Virion;APC-Cdc20 mediated degradation of Nek2A;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;EGFR downregulation;SCF(Skp2)-mediated degradation of p27/p21;Viral mRNA Translation;Degradation of beta-catenin by the destruction complex;TCF dependent signaling in response to WNT;Downstream TCR signaling;NRIF signals cell death from the nucleus;p75NTR recruits signalling complexes;NF-kB is activated and signals survival;Regulation of activated PAK-2p34 by proteasome mediated degradation;NOTCH1 Intracellular Domain Regulates Transcription;Activated NOTCH1 Transmits Signal to the Nucleus;Activated NOTCH1 Transmits Signal to the Nucleus;Downregulation of TGF-beta receptor signaling;Downregulation of TGF-beta receptor signaling;TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);Downregulation of SMAD2/3:SMAD4 transcriptional activity;Downregulation of SMAD2/3:SMAD4 transcriptional activity;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;Selenocysteine synthesis;Separation of Sister Chromatids;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);Oncogene Induced Senescence;Regulation of PLK1 Activity at G2/M Transition;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Stimuli-sensing channels;Constitutive Signaling by NOTCH1 HD Domain Mutants;FCERI mediated NF-kB activation;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;NOTCH2 Activation and Transmission of Signal to the Nucleus;Regulation of innate immune responses to cytosolic DNA;Glycogen synthesis;Autodegradation of the E3 ubiquitin ligase COP1;Deactivation of the beta-catenin transactivating complex;Myoclonic epilepsy of Lafora;ABC-family proteins mediated transport;Circadian Clock;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;activated TAK1 mediates p38 MAPK activation;JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Regulation of FZD by ubiquitination;Pink/Parkin Mediated Mitophagy;N-glycan trimming in the ER and Calnexin/Calreticulin cycle;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Hedgehog 'on' state;Negative regulation of FGFR1 signaling;Negative regulation of FGFR2 signaling;Negative regulation of FGFR3 signaling;Negative regulation of FGFR4 signaling;Translesion synthesis by POLK;Translesion synthesis by POLI;Termination of translesion DNA synthesis;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;Negative regulation of MAPK pathway;Regulation of necroptotic cell death;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAP3K8 (TPL2)-dependent MAPK1/3 activation;HDR through Homologous Recombination (HRR);MAPK6/MAPK4 signaling;UCH proteinases;UCH proteinases;Josephin domain DUBs;Ub-specific processing proteases;Ovarian tumor domain proteases;Metalloprotease DUBs;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Processing of DNA double-strand break ends;DNA Damage Recognition in GG-NER;Formation of Incision Complex in GG-NER;Gap-filling DNA repair synthesis and ligation in GG-NER;Dual Incision in GG-NER;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Fanconi Anemia Pathway;Major pathway of rRNA processing in the nucleolus and cytosol;Regulation of TP53 Activity through Phosphorylation;Regulation of TP53 Degradation;Regulation of TP53 Activity through Methylation;Negative regulation of MET activity;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;Cyclin D associated events in G1;G2/M Checkpoints;Stabilization of p53;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Downregulation of ERBB2 signaling;Synthesis of active ubiquitin: roles of E1 and E2 enzymes;Synthesis of active ubiquitin: roles of E1 and E2 enzymes;E3 ubiquitin ligases ubiquitinate target proteins;InlB-mediated entry of Listeria monocytogenes into host cell;InlA-mediated entry of Listeria monocytogenes into host cells;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN localization;Regulation of PTEN stability and activity;Neddylation;ER Quality Control Compartment (ERQC);Regulation of expression of SLITs and ROBOs;Regulation of expression of SLITs and ROBOs;NOTCH3 Activation and Transmission of Signal to the Nucleus;NOTCH3 Activation and Transmission of Signal to the Nucleus;TICAM1-dependent activation of IRF3/IRF7;TICAM1,TRAF6-dependent induction of TAK1 complex;Interleukin-1 signaling;Peroxisomal protein import;Peroxisomal protein import;Regulation of signaling by CBL;Endosomal Sorting Complex Required For Transport (ESCRT);Iron uptake and transport;Negative regulators of DDX58/IFIH1 signaling;Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon;IRAK1 recruits IKK complex;IKK complex recruitment mediated by RIP1;IRAK2 mediated activation of TAK1 complex;TRAF6-mediated induction of TAK1 complex within TLR4 complex;Negative regulation of NOTCH4 signaling;TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling;IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation;IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);Amyloid fiber formation;Antigen processing: Ubiquitination & Proteasome degradation
6235	RPS29	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
6236	RRAD	False	True	NA
6240	RRM1	False	True	Interconversion of nucleotide di- and triphosphates
6241	RRM2	False	True	Interconversion of nucleotide di- and triphosphates;Activation of E2F1 target genes at G1/S;Transcriptional Regulation by E2F6
6248	RSC1A1	False	True	Organic cation transport;Intestinal hexose absorption
6251	RSU1	False	True	Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
6252	RTN1	False	True	NA
6262	RYR2	False	True	Stimuli-sensing channels;Ion homeostasis
6275	S100A4	False	True	NA
6278	S100A7	True	True	Neutrophil degranulation;Metal sequestration by antimicrobial proteins
6281	S100A10	False	True	Dissolution of Fibrin Clot
6282	S100A11	True	True	Neutrophil degranulation
6294	SAFB	False	True	SUMOylation of transcription cofactors
6301	SARS	False	True	Selenocysteine synthesis;Cytosolic tRNA aminoacylation
6303	SAT1	False	True	Interconversion of polyamines
6305	SBF1	False	True	Synthesis of PIPs at the ER membrane;RAB GEFs exchange GTP for GDP on RABs
6310	ATXN1	False	True	NA
6317	SERPINB3	True	True	Neutrophil degranulation
6318	SERPINB4	True	True	NA
6319	SCD	False	True	Activation of gene expression by SREBF (SREBP);Fatty acyl-CoA biosynthesis
6331	SCN5A	False	True	Interaction between L1 and Ankyrins;Phase 0 - rapid depolarisation
6340	SCNN1G	False	True	Stimuli-sensing channels
6386	SDCBP	False	True	Ephrin signaling;Neurofascin interactions;Neutrophil degranulation
6390	SDHB	False	True	Respiratory electron transport;Citric acid cycle (TCA cycle)
6396	SEC13	False	True	ISG15 antiviral mechanism;Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Rev-mediated nuclear export of HIV RNA;Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Viral Messenger RNA Synthesis;NEP/NS2 Interacts with the Cellular Export Machinery;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;snRNP Assembly;COPII-mediated vesicle transport;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;SUMOylation of DNA damage response and repair proteins;SUMOylation of ubiquitinylation proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;SUMOylation of SUMOylation proteins;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;Transcriptional regulation by small RNAs;RHO GTPases Activate Formins;tRNA processing in the nucleus;Mitotic Prometaphase;Antigen Presentation: Folding, assembly and peptide loading of class I MHC
6399	TRAPPC2	False	True	COPII-mediated vesicle transport;RAB GEFs exchange GTP for GDP on RABs
6400	SEL1L	False	True	Pre-NOTCH Processing in Golgi;ABC-family proteins mediated transport;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Defective CFTR causes cystic fibrosis;ER Quality Control Compartment (ERQC)
6418	SET	False	True	Condensation of Prophase Chromosomes;HuR (ELAVL1) binds and stabilizes mRNA
6421	SFPQ	False	True	PTK6 Regulates Proteins Involved in RNA Processing
6426	SRSF1	False	True	Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;mRNA 3'-end processing
6427	SRSF2	False	True	Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;mRNA 3'-end processing
6428	SRSF3	False	True	Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing
6429	SRSF4	False	True	Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing
6430	SRSF5	False	True	Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing
6431	SRSF6	False	True	Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;mRNA 3'-end processing
6432	SRSF7	False	True	Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;mRNA 3'-end processing
6434	TRA2B	False	True	mRNA Splicing - Major Pathway
6440	SFTPC	False	True	Surfactant metabolism;Defective pro-SFTPC causes pulmonary surfactant metabolism dysfunction 2 (SMDP2) and respiratory distress syndrome (RDS);Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5);Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)
6441	SFTPD	False	True	Toll Like Receptor 4 (TLR4) Cascade;Toll Like Receptor TLR1:TLR2 Cascade;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Signal regulatory protein family interactions;Surfactant metabolism;Regulation of TLR by endogenous ligand;Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5);Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)
6446	SGK1	False	True	Stimuli-sensing channels;Regulation of TP53 Degradation;Transcriptional Regulation by MECP2
6449	SGTA	False	True	NA
6450	SH3BGR	False	True	NA
6455	SH3GL1	False	True	EGFR downregulation;Negative regulation of MET activity;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;InlB-mediated entry of Listeria monocytogenes into host cell
6456	SH3GL2	False	True	Retrograde neurotrophin signalling;Retrograde neurotrophin signalling;EGFR downregulation;MHC class II antigen presentation;Lysosome Vesicle Biogenesis;Golgi Associated Vesicle Biogenesis;Recycling pathway of L1;Recycling pathway of L1;Negative regulation of MET activity;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;InlB-mediated entry of Listeria monocytogenes into host cell
6472	SHMT2	False	True	Metabolism of folate and pterines
6477	SIAH1	False	True	Netrin-1 signaling;Amyloid fiber formation;Antigen processing: Ubiquitination & Proteasome degradation
6493	SIM2	False	True	NA
6494	SIPA1	False	True	Rap1 signalling
6500	SKP1	False	True	Activation of NF-kappaB in B cells;Prolactin receptor signaling;SCF-beta-TrCP mediated degradation of Emi1;Vpu mediated degradation of CD4;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;NOTCH1 Intracellular Domain Regulates Transcription;Regulation of PLK1 Activity at G2/M Transition;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling;FCERI mediated NF-kB activation;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Circadian Clock;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;NIK-->noncanonical NF-kB signaling;MAP3K8 (TPL2)-dependent MAPK1/3 activation;Orc1 removal from chromatin;Cyclin D associated events in G1;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Neddylation;Interleukin-1 signaling;Iron uptake and transport;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation
6502	SKP2	False	True	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;SCF(Skp2)-mediated degradation of p27/p21;Ub-specific processing proteases;Orc1 removal from chromatin;Cyclin D associated events in G1;Regulation of RUNX2 expression and activity;Neddylation;Antigen processing: Ubiquitination & Proteasome degradation
6505	SLC1A1	False	True	Glutamate Neurotransmitter Release Cycle;Transport of inorganic cations/anions and amino acids/oligopeptides;Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA)
6510	SLC1A5	False	True	Amino acid transport across the plasma membrane
6518	SLC2A5	False	True	Neutrophil degranulation;Intestinal hexose absorption
6520	SLC3A2	False	True	Basigin interactions;Amino acid transport across the plasma membrane;Tryptophan catabolism
6531	SLC6A3	False	True	Dopamine clearance from the synaptic cleft;Na+/Cl- dependent neurotransmitter transporters;Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS);Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)
6541	SLC7A1	False	True	Amino acid transport across the plasma membrane
6548	SLC9A1	False	True	Hyaluronan uptake and degradation;Sodium/Proton exchangers
6586	NA	False	True	Netrin-1 signaling;Signaling by ROBO receptors;Signaling by ROBO receptors;Regulation of commissural axon pathfinding by SLIT and ROBO
6588	SLN	False	True	Ion homeostasis;Ion transport by P-type ATPases
6595	SMARCA2	False	True	RMTs methylate histone arginines;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
6597	SMARCA4	False	True	Interleukin-7 signaling;Formation of the beta-catenin:TCF transactivating complex;RMTs methylate histone arginines;Chromatin modifying enzymes;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
6602	SMARCD1	False	True	RMTs methylate histone arginines;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
6605	SMARCE1	False	True	RMTs methylate histone arginines;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
6606	SMN1	False	True	snRNP Assembly
6612	SUMO3	False	True	SUMO is conjugated to E1 (UBA2:SAE1);SUMO is transferred from E1 to E2 (UBE2I, UBC9);SUMO is proteolytically processed;SUMOylation of DNA damage response and repair proteins;SUMOylation of transcription factors;SUMOylation of transcription cofactors;SUMOylation of intracellular receptors;SUMOylation of intracellular receptors;SUMOylation of chromatin organization proteins;SUMOylation of DNA replication proteins;SUMOylation of immune response proteins;Formation of Incision Complex in GG-NER
6613	SUMO2	False	True	Vitamin D (calciferol) metabolism;SUMO is conjugated to E1 (UBA2:SAE1);SUMO is transferred from E1 to E2 (UBE2I, UBC9);SUMO is proteolytically processed;SUMOylation of DNA damage response and repair proteins;SUMOylation of transcription factors;SUMOylation of transcription cofactors;SUMOylation of SUMOylation proteins;SUMOylation of intracellular receptors;SUMOylation of intracellular receptors;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;Processing of DNA double-strand break ends;Formation of Incision Complex in GG-NER
6617	SNAPC1	False	True	RNA polymerase II transcribes snRNA genes;RNA polymerase II transcribes snRNA genes;RNA Polymerase III Abortive And Retractive Initiation;RNA Polymerase III Transcription Initiation From Type 3 Promoter;RNA Polymerase III Transcription Initiation From Type 3 Promoter
6620	SNCB	False	True	MTF1 activates gene expression
6622	SNCA	False	True	Amyloid fiber formation
6625	SNRNP70	False	True	mRNA Splicing - Major Pathway
6626	SNRPA	False	True	mRNA Splicing - Major Pathway
6627	SNRPA1	False	True	mRNA Splicing - Major Pathway;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
6628	SNRPB	False	True	Cleavage of Growing Transcript in the Termination Region ;SLBP independent Processing of Histone Pre-mRNAs;snRNP Assembly;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
6631	SNRPC	False	True	mRNA Splicing - Major Pathway
6632	SNRPD1	False	True	snRNP Assembly;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway
6633	SNRPD2	False	True	snRNP Assembly;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway
6634	SNRPD3	False	True	Cleavage of Growing Transcript in the Termination Region ;SLBP independent Processing of Histone Pre-mRNAs;snRNP Assembly;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
6636	SNRPF	False	True	Cleavage of Growing Transcript in the Termination Region ;SLBP independent Processing of Histone Pre-mRNAs;snRNP Assembly;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
6638	SNRPN	False	True	mRNA Splicing - Major Pathway
6647	SOD1	True	True	Platelet degranulation ;Detoxification of Reactive Oxygen Species;Detoxification of Reactive Oxygen Species;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
6648	SOD2	False	True	Transcriptional activation of mitochondrial biogenesis;Detoxification of Reactive Oxygen Species;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
6651	SON	False	True	NA
6652	SORD	False	True	Fructose biosynthesis;Formation of xylulose-5-phosphate
6667	SP1	False	True	PPARA activates gene expression;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;Activation of gene expression by SREBF (SREBP);Oncogene Induced Senescence;RNA polymerase II transcribes snRNA genes;RNA polymerase II transcribes snRNA genes;Estrogen-dependent gene expression
6675	UAP1	False	True	Synthesis of UDP-N-acetyl-glucosamine
6683	SPAST	False	True	NA
6693	SPN	False	True	Cell surface interactions at the vascular wall;Basigin interactions
6697	SPR	False	True	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation;eNOS activation
6699	NA	True	False	Formation of the cornified envelope
6704	NA	True	False	Formation of the cornified envelope
6708	SPTA1	False	True	NCAM signaling for neurite out-growth;NCAM signaling for neurite out-growth;Interaction between L1 and Ankyrins;Interaction between L1 and Ankyrins;RAF/MAP kinase cascade;COPI-mediated anterograde transport
6709	SPTAN1	False	True	Caspase-mediated cleavage of cytoskeletal proteins;Nephrin family interactions;NCAM signaling for neurite out-growth;NCAM signaling for neurite out-growth;Interaction between L1 and Ankyrins;Interaction between L1 and Ankyrins;RAF/MAP kinase cascade;Neutrophil degranulation;COPI-mediated anterograde transport
6711	SPTBN1	False	True	Nephrin family interactions;NCAM signaling for neurite out-growth;NCAM signaling for neurite out-growth;Interaction between L1 and Ankyrins;Interaction between L1 and Ankyrins;RAF/MAP kinase cascade;COPI-mediated anterograde transport
6712	SPTBN2	False	True	MHC class II antigen presentation;NCAM signaling for neurite out-growth;NCAM signaling for neurite out-growth;Interaction between L1 and Ankyrins;Interaction between L1 and Ankyrins;RAF/MAP kinase cascade;COPI-mediated anterograde transport
6713	SQLE	False	True	Cholesterol biosynthesis;Activation of gene expression by SREBF (SREBP)
6714	SRC	False	True	Signaling by ERBB2;Nuclear signaling by ERBB4;PIP3 activates AKT signaling;Spry regulation of FGF signaling;Signaling by SCF-KIT;Signaling by SCF-KIT;Regulation of KIT signaling;p38MAPK events;Signaling by EGFR;GAB1 signalosome;Downstream signal transduction;c-src mediated regulation of Cx43 function and closure of gap junctions;FCGR activation;PECAM1 interactions;Constitutive Signaling by Aberrant PI3K in Cancer;EPH-Ephrin signaling;Integrin alphaIIb beta3 signaling;GRB2:SOS provides linkage to MAPK signaling for Integrins ;p130Cas linkage to MAPK signaling for integrins;NCAM signaling for neurite out-growth;CD28 co-stimulation;CTLA4 inhibitory signaling;Signal regulatory protein family interactions;EPHB-mediated forward signaling;EPHB-mediated forward signaling;EPHA-mediated growth cone collapse;EPHA-mediated growth cone collapse;Ephrin signaling;Ephrin signaling;EPH-ephrin mediated repulsion of cells;G alpha (s) signalling events;ADP signalling through P2Y purinoceptor 1;G alpha (i) signalling events;DCC mediated attractive signaling;DCC mediated attractive signaling;Netrin mediated repulsion signals;Regulation of commissural axon pathfinding by SLIT and ROBO;GP1b-IX-V activation signalling;Recycling pathway of L1;VEGFA-VEGFR2 Pathway;VEGFA-VEGFR2 Pathway;Thrombin signalling through proteinase activated receptors (PARs);VEGFR2 mediated cell proliferation;CLEC7A (Dectin-1) signaling;RHO GTPases Activate Formins;RAF activation;MAP2K and MAPK activation;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Cyclin D associated events in G1;RET signaling;MET activates PTK2 signaling;InlA-mediated entry of Listeria monocytogenes into host cells;Regulation of RUNX1 Expression and Activity;Receptor Mediated Mitophagy;RUNX2 regulates osteoblast differentiation;Regulation of RUNX3 expression and activity;Activated NTRK2 signals through FYN;Activated NTRK3 signals through PI3K;Activated NTRK3 signals through PI3K;Long-term potentiation
6717	SRI	False	True	Stimuli-sensing channels;Reduction of cytosolic Ca++ levels;Sodium/Calcium exchangers;Ion homeostasis;Ion transport by P-type ATPases
6720	SREBF1	False	True	RORA activates gene expression;Regulation of cholesterol biosynthesis by SREBP (SREBF);Regulation of cholesterol biosynthesis by SREBP (SREBF);PPARA activates gene expression;Activation of gene expression by SREBF (SREBP);Activation of gene expression by SREBF (SREBP);Transcriptional regulation of white adipocyte differentiation;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
6726	SRP9	False	True	SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane
6727	SRP14	False	True	SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Neutrophil degranulation
6728	SRP19	False	True	SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane
6729	SRP54	False	True	SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane
6731	SRP72	False	True	SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane
6732	SRPK1	False	True	NA
6737	TRIM21	False	True	STING mediated induction of host immune responses;Regulation of innate immune responses to cytosolic DNA;Interferon gamma signaling;Antigen processing: Ubiquitination & Proteasome degradation
6741	SSB	False	True	RNA Polymerase III Transcription Termination;RNA Polymerase III Abortive And Retractive Initiation
6742	SSBP1	False	True	Transcriptional activation of mitochondrial biogenesis
6744	SSFA2	False	True	NA
6747	SSR3	False	True	SRP-dependent cotranslational protein targeting to membrane
6748	SSR4	False	True	SRP-dependent cotranslational protein targeting to membrane
6749	SSRP1	False	True	Formation of RNA Pol II elongation complex ;Formation of HIV elongation complex in the absence of HIV Tat;Formation of HIV-1 elongation complex containing HIV-1 Tat;Pausing and recovery of Tat-mediated HIV elongation;Tat-mediated HIV elongation arrest and recovery;Tat-mediated elongation of the HIV-1 transcript;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;RNA Polymerase II Pre-transcription Events;TP53 Regulates Transcription of DNA Repair Genes;Regulation of TP53 Activity through Phosphorylation;RNA Polymerase II Transcription Elongation
6764	ST5	False	True	RAB GEFs exchange GTP for GDP on RABs
6767	ST13	False	True	Regulation of HSF1-mediated heat shock response
6769	STAC	False	True	NA
6772	STAT1	False	True	Interleukin-6 signaling;ISG15 antiviral mechanism;Signaling by SCF-KIT;Signaling by cytosolic FGFR1 fusion mutants;Downstream signal transduction;Interleukin-4 and Interleukin-13 signaling;Interferon gamma signaling;Regulation of IFNG signaling;Interleukin-20 family signaling;Regulation of RUNX2 expression and activity;Interleukin-35 Signalling;Interleukin-9 signaling;NOTCH3 Intracellular Domain Regulates Transcription;NOTCH3 Intracellular Domain Regulates Transcription;Interleukin-27 signaling;Interleukin-21 signaling;Interferon alpha/beta signaling;Regulation of IFNA signaling;Growth hormone receptor signaling
6773	STAT2	False	True	Interleukin-20 family signaling;Interferon alpha/beta signaling;Regulation of IFNA signaling;Regulation of IFNA signaling
6774	STAT3	False	True	Interleukin-6 signaling;BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members;Interleukin-7 signaling;Interleukin-7 signaling;Signaling by SCF-KIT;Signaling by cytosolic FGFR1 fusion mutants;Downstream signal transduction;Signalling to STAT3;Senescence-Associated Secretory Phenotype (SASP);Signaling by Leptin;POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation;Association of TriC/CCT with target proteins during biosynthesis;Transcriptional regulation of pluripotent stem cells;Interleukin-10 signaling;Interleukin-4 and Interleukin-13 signaling;PTK6 Activates STAT3;PTK6 Activates STAT3;Interleukin-20 family signaling;MET activates STAT3;MET activates STAT3;Interleukin-15 signaling;Interleukin-35 Signalling;Interleukin-9 signaling;Interleukin-37 signaling;Interleukin-23 signaling;Interleukin-23 signaling;Interleukin-27 signaling;Interleukin-21 signaling;Growth hormone receptor signaling
6778	STAT6	False	True	Downstream signal transduction;STAT6-mediated induction of chemokines;Interleukin-4 and Interleukin-13 signaling
6779	NA	False	True	NA
6780	STAU1	False	True	NA
6785	ELOVL4	False	True	Synthesis of very long-chain fatty acyl-CoAs
6786	STIM1	False	True	Elevation of cytosolic Ca2+ levels;Ion homeostasis;Ion homeostasis;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
6793	STK10	False	True	Neutrophil degranulation
6794	STK11	False	True	AMPK inhibits chREBP transcriptional activation activity;Energy dependent regulation of mTOR by LKB1-AMPK;Regulation of TP53 Activity through Phosphorylation;FOXO-mediated transcription of cell death genes
6795	AURKC	False	True	NA
6801	STRN	False	True	NA
6809	STX3	False	True	Other interleukin signaling
6810	STX4	False	True	Disinhibition of SNARE formation;ER-Phagosome pathway;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Clathrin derived vesicle budding;Other interleukin signaling
6811	STX5	False	True	COPII-mediated vesicle transport;Cargo concentration in the ER;COPI-mediated anterograde transport;Intra-Golgi traffic
6812	STXBP1	False	True	Serotonin Neurotransmitter Release Cycle;Norepinephrine Neurotransmitter Release Cycle;Glutamate Neurotransmitter Release Cycle;Dopamine Neurotransmitter Release Cycle;Acetylcholine Neurotransmitter Release Cycle;Regulation of insulin secretion;Neurexins and neuroligins;GABA synthesis, release, reuptake and degradation
6813	STXBP2	False	True	Platelet degranulation ;Other interleukin signaling
6829	SUPT5H	False	True	Formation of RNA Pol II elongation complex ;Formation of the Early Elongation Complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of the HIV-1 Early Elongation Complex;RNA Pol II CTD phosphorylation and interaction with CE during HIV infection;Formation of HIV-1 elongation complex containing HIV-1 Tat;Formation of HIV-1 elongation complex containing HIV-1 Tat;Pausing and recovery of Tat-mediated HIV elongation;Abortive elongation of HIV-1 transcript in the absence of Tat;Tat-mediated HIV elongation arrest and recovery;Tat-mediated elongation of the HIV-1 transcript;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;RNA Polymerase II Pre-transcription Events;TP53 Regulates Transcription of DNA Repair Genes;RNA polymerase II transcribes snRNA genes;mRNA Capping;RNA Polymerase II Transcription Elongation;RNA Pol II CTD phosphorylation and interaction with CE
6835	SURF2	False	True	NA
6836	SURF4	False	True	Neutrophil degranulation;COPI-dependent Golgi-to-ER retrograde traffic
6840	SVIL	False	True	NA
6843	VAMP1	False	True	Toxicity of botulinum toxin type D (BoNT/D);Toxicity of botulinum toxin type F (BoNT/F);Toxicity of botulinum toxin type G (BoNT/G)
6844	VAMP2	False	True	Translocation of SLC2A4 (GLUT4) to the plasma membrane;Serotonin Neurotransmitter Release Cycle;Norepinephrine Neurotransmitter Release Cycle;Glutamate Neurotransmitter Release Cycle;Dopamine Neurotransmitter Release Cycle;Acetylcholine Neurotransmitter Release Cycle;Insulin processing;Clathrin derived vesicle budding;Regulation of insulin secretion;Lysosome Vesicle Biogenesis;Golgi Associated Vesicle Biogenesis;Other interleukin signaling;Toxicity of botulinum toxin type D (BoNT/D);Toxicity of botulinum toxin type B (BoNT/B);Toxicity of botulinum toxin type F (BoNT/F);Toxicity of tetanus toxin (TeNT);Toxicity of botulinum toxin type G (BoNT/G);Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;GABA synthesis, release, reuptake and degradation
6856	SYPL1	False	True	NA
6867	TACC1	False	True	NA
6871	TADA2A	False	True	HATs acetylate histones
6873	TAF2	False	True	HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;RNA Polymerase II Pre-transcription Events;Regulation of TP53 Activity through Phosphorylation;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance
6876	TAGLN	False	True	NA
6885	MAP3K7	False	True	Activation of NF-kappaB in B cells;NOD1/2 Signaling Pathway;Downstream TCR signaling;FCERI mediated NF-kB activation;Ca2+ pathway;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;activated TAK1 mediates p38 MAPK activation;JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1;TNFR1-induced NFkappaB signaling pathway;CLEC7A (Dectin-1) signaling;Ub-specific processing proteases;TICAM1,TRAF6-dependent induction of TAK1 complex;Interleukin-1 signaling;IRAK2 mediated activation of TAK1 complex;TRAF6-mediated induction of TAK1 complex within TLR4 complex;IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
6888	TALDO1	False	True	Insulin effects increased synthesis of Xylulose-5-Phosphate;TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P;TALDO1 deficiency: failed conversion of  Fru(6)P, E4P to SH7P, GA3P;Pentose phosphate pathway;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
6890	TAP1	False	True	ER-Phagosome pathway;ER-Phagosome pathway;Antigen Presentation: Folding, assembly and peptide loading of class I MHC
6894	TARBP1	False	True	NA
6895	TARBP2	False	True	MicroRNA (miRNA) biogenesis;Small interfering RNA (siRNA) biogenesis
6897	TARS	False	True	Cytosolic tRNA aminoacylation
6902	TBCA	False	True	Post-chaperonin tubulin folding pathway
6905	TBCE	False	True	Post-chaperonin tubulin folding pathway
6907	TBL1X	False	True	RORA activates gene expression;BMAL1:CLOCK,NPAS2 activates circadian gene expression;PPARA activates gene expression;PPARA activates gene expression;NOTCH1 Intracellular Domain Regulates Transcription;Transcriptional activation of mitochondrial biogenesis;Activation of gene expression by SREBF (SREBP);Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;HDACs deacetylate histones;Transcriptional regulation of white adipocyte differentiation;Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha);Circadian Clock;Loss of MECP2 binding ability to the NCoR/SMRT complex;Regulation of MECP2 expression and activity
6908	TBP	False	True	HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;SIRT1 negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;B-WICH complex positively regulates rRNA expression;RNA Polymerase II Pre-transcription Events;Regulation of TP53 Activity through Phosphorylation;RNA polymerase II transcribes snRNA genes;RNA polymerase II transcribes snRNA genes;RNA Polymerase I Transcription Initiation;RNA Polymerase I Transcription Initiation;RNA Polymerase I Promoter Escape;RNA Polymerase II Promoter Escape;RNA Polymerase I Chain Elongation;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase I Transcription Termination;RNA Polymerase III Abortive And Retractive Initiation;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Polymerase III Transcription Initiation From Type 1 Promoter;RNA Polymerase III Transcription Initiation From Type 1 Promoter;RNA Polymerase III Transcription Initiation From Type 2 Promoter;RNA Polymerase III Transcription Initiation From Type 2 Promoter;RNA Polymerase III Transcription Initiation From Type 3 Promoter;RNA Polymerase III Transcription Initiation From Type 3 Promoter;Estrogen-dependent gene expression
6919	TCEA2	False	True	NA
6924	TCEB3	False	True	Formation of RNA Pol II elongation complex ;Formation of HIV elongation complex in the absence of HIV Tat;Formation of HIV-1 elongation complex containing HIV-1 Tat;Pausing and recovery of Tat-mediated HIV elongation;Tat-mediated HIV elongation arrest and recovery;Tat-mediated elongation of the HIV-1 transcript;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;RNA Polymerase II Pre-transcription Events;TP53 Regulates Transcription of DNA Repair Genes;RNA Polymerase II Transcription Elongation
6925	TCF4	False	True	CDO in myogenesis;CDO in myogenesis
6934	TCF7L2	False	True	Formation of the beta-catenin:TCF transactivating complex;Formation of the beta-catenin:TCF transactivating complex;Deactivation of the beta-catenin transactivating complex;Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1);Ca2+ pathway;Binding of TCF/LEF:CTNNB1 to target gene promoters;Repression of WNT target genes;Repression of WNT target genes;TCF7L2 mutants don't bind CTBP;RUNX3 regulates WNT signaling
6950	TCP1	False	True	Prefoldin mediated transfer of substrate  to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Folding of actin by CCT/TriC;Association of TriC/CCT with target proteins during biosynthesis;Association of TriC/CCT with target proteins during biosynthesis;BBSome-mediated cargo-targeting to cilium;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
6999	TDO2	False	True	Tryptophan catabolism
7001	PRDX2	False	True	Detoxification of Reactive Oxygen Species;TP53 Regulates Metabolic Genes;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
7013	TERF1	False	True	Meiotic synapsis;Packaging Of Telomere Ends;DNA Damage/Telomere Stress Induced Senescence
7014	TERF2	False	True	Meiotic synapsis;Packaging Of Telomere Ends;DNA Damage/Telomere Stress Induced Senescence
7015	TERT	False	True	Telomere Extension By Telomerase;Formation of the beta-catenin:TCF transactivating complex
7016	TESK1	False	True	Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
7018	TF	True	True	Platelet degranulation ;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Post-translational protein phosphorylation;Iron uptake and transport;Transferrin endocytosis and recycling
7026	NR2F2	False	True	Transcriptional regulation of white adipocyte differentiation
7037	TFRC	False	True	Golgi Associated Vesicle Biogenesis;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Transferrin endocytosis and recycling
7038	TG	False	True	NA
7040	TGFB1	False	True	Platelet degranulation ;Influenza Virus Induced Apoptosis;Cell surface interactions at the vascular wall;Molecules associated with elastic fibres;Downregulation of TGF-beta receptor signaling;Downregulation of TGF-beta receptor signaling;TGF-beta receptor signaling activates SMADs;TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);Syndecan interactions;ECM proteoglycans;SMAD2/3 Phosphorylation Motif Mutants in Cancer;SMAD2/3 MH2 Domain Mutants in Cancer;TGFBR2 MSI Frameshift Mutants in Cancer;TGFBR2 Kinase Domain Mutants in Cancer;TGFBR1 KD Mutants in Cancer;TGFBR1 LBD Mutants in Cancer;Transcriptional regulation of white adipocyte differentiation;UCH proteinases;Interleukin-4 and Interleukin-13 signaling;RUNX3 regulates CDKN1A transcription;Regulation of RUNX3 expression and activity;RUNX3 regulates p14-ARF
7041	TGFB1I1	False	True	NA
7046	TGFBR1	False	True	Downregulation of TGF-beta receptor signaling;Downregulation of TGF-beta receptor signaling;TGF-beta receptor signaling activates SMADs;TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);SMAD2/3 Phosphorylation Motif Mutants in Cancer;SMAD2/3 MH2 Domain Mutants in Cancer;TGFBR2 Kinase Domain Mutants in Cancer;TGFBR1 KD Mutants in Cancer;TGFBR1 LBD Mutants in Cancer;UCH proteinases;Ub-specific processing proteases
7048	TGFBR2	False	True	Downregulation of TGF-beta receptor signaling;Downregulation of TGF-beta receptor signaling;TGF-beta receptor signaling activates SMADs;TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);SMAD2/3 Phosphorylation Motif Mutants in Cancer;SMAD2/3 MH2 Domain Mutants in Cancer;TGFBR2 MSI Frameshift Mutants in Cancer;TGFBR2 Kinase Domain Mutants in Cancer;TGFBR1 KD Mutants in Cancer;TGFBR1 LBD Mutants in Cancer;UCH proteinases
7052	TGM2	False	True	NA
7053	TGM3	True	True	NA
7056	THBD	False	True	Common Pathway of Fibrin Clot Formation;Cell surface interactions at the vascular wall
7064	THOP1	False	True	Antigen processing: Ubiquitination & Proteasome degradation
7067	THRA	False	True	Nuclear Receptor transcription pathway;SUMOylation of intracellular receptors
7073	TIAL1	False	True	FGFR2 alternative splicing
7074	TIAM1	False	True	NRAGE signals death through JNK;Rho GTPase cycle;EPHB-mediated forward signaling;EPH-ephrin mediated repulsion of cells;G alpha (12/13) signalling events;Activated NTRK2 signals through CDK5
7075	TIE1	False	True	NA
7082	TJP1	False	True	c-src mediated regulation of Cx43 function and closure of gap junctions;c-src mediated regulation of Cx43 function and closure of gap junctions;Signaling by Hippo;Apoptotic cleavage of cell adhesion  proteins;RUNX1 regulates expression of components of tight junctions
7086	TKT	False	True	Insulin effects increased synthesis of Xylulose-5-Phosphate;Pentose phosphate pathway
7094	TLN1	False	True	Platelet degranulation ;Integrin alphaIIb beta3 signaling;GRB2:SOS provides linkage to MAPK signaling for Integrins ;p130Cas linkage to MAPK signaling for integrins;XBP1(S) activates chaperone genes;SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion;Smooth Muscle Contraction;MAP2K and MAPK activation;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF
7102	NA	False	True	Cell surface interactions at the vascular wall;Trafficking of GluR2-containing AMPA receptors
7105	TSPAN6	False	True	NA
7111	TMOD1	False	True	Striated Muscle Contraction
7112	TMPO	False	True	Clearance of Nuclear Envelope Membranes from Chromatin;Initiation of Nuclear Envelope Reformation;Depolymerisation of the Nuclear Lamina
7114	TMSB4X	False	True	Platelet degranulation
7124	TNF	False	True	Transcriptional regulation of white adipocyte differentiation;TNFR1-induced proapoptotic signaling;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;TNFR1-mediated ceramide production;TNFR2 non-canonical NF-kB pathway;Interleukin-10 signaling;Interleukin-4 and Interleukin-13 signaling;TNF signaling
7126	TNFAIP1	False	True	NA
7128	TNFAIP3	False	True	NOD1/2 Signaling Pathway;TNFR1-induced proapoptotic signaling;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;Ovarian tumor domain proteases;Negative regulators of DDX58/IFIH1 signaling
7145	TNS1	False	True	NA
7150	TOP1	False	True	SUMOylation of DNA replication proteins
7153	TOP2A	False	True	Transcription of E2F targets under negative control by DREAM complex;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins
7157	TP53	False	True	Activation of NOXA and translocation to mitochondria;Activation of PUMA and translocation to mitochondria;Pre-NOTCH Transcription and Translation;Oxidative Stress Induced Senescence;Formation of Senescence-Associated Heterochromatin Foci (SAHF);Oncogene Induced Senescence;DNA Damage/Telomere Stress Induced Senescence;SUMOylation of transcription factors;Autodegradation of the E3 ubiquitin ligase COP1;Association of TriC/CCT with target proteins during biosynthesis;TP53 Regulates Metabolic Genes;Ub-specific processing proteases;Ovarian tumor domain proteases;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Interleukin-4 and Interleukin-13 signaling;TP53 Regulates Transcription of DNA Repair Genes;TP53 Regulates Transcription of Genes Involved in Cytochrome C Release;TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain;TP53 Regulates Transcription of Caspase Activators and Caspases;TP53 Regulates Transcription of Death Receptors and Ligands;TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest;TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain;TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest;Regulation of TP53 Expression;Regulation of TP53 Activity through Phosphorylation;Regulation of TP53 Degradation;Regulation of TP53 Activity through Acetylation;Regulation of TP53 Activity through Association with Co-factors;Regulation of TP53 Activity through Methylation;PI5P Regulates TP53 Acetylation;G2/M DNA damage checkpoint;G2/M Checkpoints;Stabilization of p53;Transcriptional  activation of  cell cycle inhibitor p21 ;The role of GTSE1 in G2/M progression after G2 checkpoint;RUNX3 regulates CDKN1A transcription;Regulation of PTEN gene transcription;Regulation of PTEN gene transcription;Factors involved in megakaryocyte development and platelet production
7158	TP53BP1	False	True	SUMOylation of transcription factors;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Processing of DNA double-strand break ends;G2/M DNA damage checkpoint
7159	TP53BP2	False	True	Activation of PUMA and translocation to mitochondria;TP53 Regulates Transcription of Genes Involved in Cytochrome C Release;TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain;TP53 Regulates Transcription of Death Receptors and Ligands;Regulation of TP53 Activity through Association with Co-factors
7163	TPD52	False	True	Golgi Associated Vesicle Biogenesis
7165	TPD52L2	False	True	NA
7167	TPI1	True	True	Glycolysis;Gluconeogenesis
7168	TPM1	False	True	Striated Muscle Contraction;Smooth Muscle Contraction
7169	TPM2	False	True	Striated Muscle Contraction;Smooth Muscle Contraction
7170	TPM3	False	True	Striated Muscle Contraction;Smooth Muscle Contraction
7171	TPM4	False	True	Striated Muscle Contraction;Smooth Muscle Contraction
7175	TPR	False	True	ISG15 antiviral mechanism;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Rev-mediated nuclear export of HIV RNA;Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Viral Messenger RNA Synthesis;NEP/NS2 Interacts with the Cellular Export Machinery;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;snRNP Assembly;SUMOylation of DNA damage response and repair proteins;SUMOylation of ubiquitinylation proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;SUMOylation of SUMOylation proteins;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins;Transcriptional regulation by small RNAs;Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC);tRNA processing in the nucleus
7178	TPT1	False	True	NA
7182	NR2C2	False	True	Nuclear Receptor transcription pathway
7184	HSP90B1	False	True	Trafficking and processing of endosomal TLR;Scavenging by Class A Receptors;Scavenging by Class A Receptors;ATF6 (ATF6-alpha) activates chaperone genes;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Interleukin-4 and Interleukin-13 signaling;Post-translational protein phosphorylation
7186	TRAF2	False	True	Caspase activation via Death Receptors in the presence of ligand;Regulation by c-FLIP;RIPK1-mediated regulated necrosis;CASP8 activity is inhibited;TNFR1-induced proapoptotic signaling;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;TNFR2 non-canonical NF-kB pathway;Regulation of necroptotic cell death;TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway;Ub-specific processing proteases;Dimerization of procaspase-8;TNF signaling;TRAF6 mediated IRF7 activation;TRAF6 mediated NF-kB activation;TRAF6 mediated NF-kB activation
7203	CCT3	False	True	Prefoldin mediated transfer of substrate  to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Folding of actin by CCT/TriC;Association of TriC/CCT with target proteins during biosynthesis;Association of TriC/CCT with target proteins during biosynthesis;BBSome-mediated cargo-targeting to cilium;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
7204	TRIO	False	True	NRAGE signals death through JNK;Rho GTPase cycle;G alpha (q) signalling events;G alpha (12/13) signalling events;DCC mediated attractive signaling;DCC mediated attractive signaling
7248	TSC1	False	True	Macroautophagy;Inhibition of TSC complex formation by PKB;Energy dependent regulation of mTOR by LKB1-AMPK;TP53 Regulates Metabolic Genes;TBC/RABGAPs
7249	TSC2	False	True	Macroautophagy;Inhibition of TSC complex formation by PKB;AKT phosphorylates targets in the cytosol;Energy dependent regulation of mTOR by LKB1-AMPK;TP53 Regulates Metabolic Genes;Constitutive Signaling by AKT1 E17K in Cancer;TBC/RABGAPs
7251	TSG101	False	True	Budding and maturation of HIV virion;Membrane binding and targetting of GAG proteins;Endosomal Sorting Complex Required For Transport (ESCRT)
7253	TSHR	False	True	Hormone ligand-binding receptors;G alpha (s) signalling events
7265	TTC1	False	True	NA
7266	DNAJC7	False	True	Regulation of HSF1-mediated heat shock response
7267	TTC3	False	True	NA
7268	TTC4	False	True	NA
7272	TTK	False	True	NA
7273	TTN	False	True	Platelet degranulation ;Striated Muscle Contraction
7276	TTR	False	True	Retinoid cycle disease events;The canonical retinoid cycle in rods (twilight vision);Non-integrin membrane-ECM interactions;Neutrophil degranulation;Retinoid metabolism and transport;Amyloid fiber formation
7277	TUBA4A	False	True	Platelet degranulation ;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;Gap junction assembly;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;Regulation of PLK1 Activity at G2/M Transition;HSP90 chaperone cycle for steroid hormone receptors (SHR);Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Prefoldin mediated transfer of substrate  to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Post-chaperonin tubulin folding pathway;Recycling pathway of L1;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Anchoring of the basal body to the plasma membrane;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;AURKA Activation by TPX2;Carboxyterminal post-translational modifications of tubulin;Carboxyterminal post-translational modifications of tubulin;Activation of AMPK downstream of NMDARs;Kinesins
7278	TUBA3C	False	True	Translocation of SLC2A4 (GLUT4) to the plasma membrane;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;Gap junction assembly;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HSP90 chaperone cycle for steroid hormone receptors (SHR);Recruitment of NuMA to mitotic centrosomes;Prefoldin mediated transfer of substrate  to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Post-chaperonin tubulin folding pathway;Recycling pathway of L1;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;Carboxyterminal post-translational modifications of tubulin;Carboxyterminal post-translational modifications of tubulin;Activation of AMPK downstream of NMDARs;Kinesins
7280	TUBB2A	False	True	Translocation of SLC2A4 (GLUT4) to the plasma membrane;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;Gap junction assembly;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HSP90 chaperone cycle for steroid hormone receptors (SHR);Recruitment of NuMA to mitotic centrosomes;Prefoldin mediated transfer of substrate  to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Post-chaperonin tubulin folding pathway;Recycling pathway of L1;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;Carboxyterminal post-translational modifications of tubulin;Carboxyterminal post-translational modifications of tubulin;Activation of AMPK downstream of NMDARs;Kinesins
7283	TUBG1	False	True	Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;AURKA Activation by TPX2
7284	TUFM	False	True	Mitochondrial translation elongation
7295	TXN	True	True	Oxidative Stress Induced Senescence;Detoxification of Reactive Oxygen Species;Interconversion of nucleotide di- and triphosphates;TP53 Regulates Metabolic Genes;Protein repair;The NLRP3 inflammasome;The NLRP3 inflammasome;Regulation of FOXO transcriptional activity by acetylation
7296	TXNRD1	False	True	PPARA activates gene expression;Metabolism of ingested H2SeO4 and H2SeO3 into H2Se;Detoxification of Reactive Oxygen Species;Interconversion of nucleotide di- and triphosphates;Metabolism of ingested MeSeO2H into MeSeH;Uptake and function of diphtheria toxin;TP53 Regulates Metabolic Genes
7297	TYK2	False	True	Interleukin-6 signaling;Interleukin-6 signaling;MAPK3 (ERK1) activation;MAPK1 (ERK2) activation;Other interleukin signaling;Interleukin-10 signaling;Interleukin-4 and Interleukin-13 signaling;IL-6-type cytokine receptor ligand interactions;Interleukin-20 family signaling;Interleukin-35 Signalling;Interleukin-12 signaling;Interleukin-12 signaling;Interleukin-23 signaling;Interleukin-23 signaling;Interleukin-27 signaling;Interleukin-27 signaling;Interferon alpha/beta signaling;Regulation of IFNA signaling;Regulation of IFNA signaling
7298	TYMS	False	True	Interconversion of nucleotide di- and triphosphates;Activation of E2F1 target genes at G1/S
7301	TYRO3	False	True	NA
7307	U2AF1	False	True	Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing
7311	UBA52	True	True	Translesion synthesis by REV1;Recognition of DNA damage by PCNA-containing replication complex;Translesion Synthesis by POLH;Activation of NF-kappaB in B cells;ISG15 antiviral mechanism;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants;ER-Phagosome pathway;Downregulation of ERBB4 signaling;Spry regulation of FGF signaling;Downregulation of ERBB2:ERBB3 signaling;L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;Budding and maturation of HIV virion;NOD1/2 Signaling Pathway;TICAM1, RIP1-mediated IKK complex recruitment ;DDX58/IFIH1-mediated induction of interferon-alpha/beta;APC/C:Cdc20 mediated degradation of Cyclin B;Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Membrane binding and targetting of GAG proteins;Assembly Of The HIV Virion;APC-Cdc20 mediated degradation of Nek2A;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;EGFR downregulation;SCF(Skp2)-mediated degradation of p27/p21;Viral mRNA Translation;Degradation of beta-catenin by the destruction complex;TCF dependent signaling in response to WNT;Downstream TCR signaling;NRIF signals cell death from the nucleus;p75NTR recruits signalling complexes;NF-kB is activated and signals survival;Regulation of activated PAK-2p34 by proteasome mediated degradation;NOTCH1 Intracellular Domain Regulates Transcription;Activated NOTCH1 Transmits Signal to the Nucleus;Activated NOTCH1 Transmits Signal to the Nucleus;Downregulation of TGF-beta receptor signaling;Downregulation of TGF-beta receptor signaling;TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);Downregulation of SMAD2/3:SMAD4 transcriptional activity;Downregulation of SMAD2/3:SMAD4 transcriptional activity;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;Selenocysteine synthesis;Separation of Sister Chromatids;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);Oncogene Induced Senescence;Regulation of PLK1 Activity at G2/M Transition;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Stimuli-sensing channels;Constitutive Signaling by NOTCH1 HD Domain Mutants;FCERI mediated NF-kB activation;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;NOTCH2 Activation and Transmission of Signal to the Nucleus;Regulation of innate immune responses to cytosolic DNA;Glycogen synthesis;Autodegradation of the E3 ubiquitin ligase COP1;Deactivation of the beta-catenin transactivating complex;Myoclonic epilepsy of Lafora;ABC-family proteins mediated transport;Circadian Clock;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;activated TAK1 mediates p38 MAPK activation;JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Regulation of FZD by ubiquitination;Pink/Parkin Mediated Mitophagy;N-glycan trimming in the ER and Calnexin/Calreticulin cycle;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Hedgehog 'on' state;Negative regulation of FGFR1 signaling;Negative regulation of FGFR2 signaling;Negative regulation of FGFR3 signaling;Negative regulation of FGFR4 signaling;Translesion synthesis by POLK;Translesion synthesis by POLI;Termination of translesion DNA synthesis;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;Negative regulation of MAPK pathway;Regulation of necroptotic cell death;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAP3K8 (TPL2)-dependent MAPK1/3 activation;HDR through Homologous Recombination (HRR);MAPK6/MAPK4 signaling;UCH proteinases;UCH proteinases;Josephin domain DUBs;Ub-specific processing proteases;Ovarian tumor domain proteases;Metalloprotease DUBs;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Processing of DNA double-strand break ends;DNA Damage Recognition in GG-NER;Formation of Incision Complex in GG-NER;Gap-filling DNA repair synthesis and ligation in GG-NER;Dual Incision in GG-NER;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Fanconi Anemia Pathway;Major pathway of rRNA processing in the nucleolus and cytosol;Regulation of TP53 Activity through Phosphorylation;Regulation of TP53 Degradation;Regulation of TP53 Activity through Methylation;Negative regulation of MET activity;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;Cyclin D associated events in G1;G2/M Checkpoints;Stabilization of p53;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Downregulation of ERBB2 signaling;Synthesis of active ubiquitin: roles of E1 and E2 enzymes;Synthesis of active ubiquitin: roles of E1 and E2 enzymes;E3 ubiquitin ligases ubiquitinate target proteins;InlB-mediated entry of Listeria monocytogenes into host cell;InlA-mediated entry of Listeria monocytogenes into host cells;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN localization;Regulation of PTEN stability and activity;Neddylation;ER Quality Control Compartment (ERQC);Regulation of expression of SLITs and ROBOs;Regulation of expression of SLITs and ROBOs;NOTCH3 Activation and Transmission of Signal to the Nucleus;NOTCH3 Activation and Transmission of Signal to the Nucleus;TICAM1-dependent activation of IRF3/IRF7;TICAM1,TRAF6-dependent induction of TAK1 complex;Interleukin-1 signaling;Peroxisomal protein import;Peroxisomal protein import;Regulation of signaling by CBL;Endosomal Sorting Complex Required For Transport (ESCRT);Iron uptake and transport;Negative regulators of DDX58/IFIH1 signaling;Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon;IRAK1 recruits IKK complex;IKK complex recruitment mediated by RIP1;IRAK2 mediated activation of TAK1 complex;TRAF6-mediated induction of TAK1 complex within TLR4 complex;Negative regulation of NOTCH4 signaling;TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling;IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation;IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);Amyloid fiber formation;Antigen processing: Ubiquitination & Proteasome degradation
7316	UBC	False	True	Translesion synthesis by REV1;Recognition of DNA damage by PCNA-containing replication complex;Translesion Synthesis by POLH;Activation of NF-kappaB in B cells;ISG15 antiviral mechanism;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants;ER-Phagosome pathway;Downregulation of ERBB4 signaling;Spry regulation of FGF signaling;Downregulation of ERBB2:ERBB3 signaling;Budding and maturation of HIV virion;NOD1/2 Signaling Pathway;TICAM1, RIP1-mediated IKK complex recruitment ;DDX58/IFIH1-mediated induction of interferon-alpha/beta;APC/C:Cdc20 mediated degradation of Cyclin B;Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Membrane binding and targetting of GAG proteins;Assembly Of The HIV Virion;APC-Cdc20 mediated degradation of Nek2A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;EGFR downregulation;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;TCF dependent signaling in response to WNT;Downstream TCR signaling;NRIF signals cell death from the nucleus;p75NTR recruits signalling complexes;NF-kB is activated and signals survival;Regulation of activated PAK-2p34 by proteasome mediated degradation;NOTCH1 Intracellular Domain Regulates Transcription;Activated NOTCH1 Transmits Signal to the Nucleus;Activated NOTCH1 Transmits Signal to the Nucleus;Downregulation of TGF-beta receptor signaling;Downregulation of TGF-beta receptor signaling;TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);Downregulation of SMAD2/3:SMAD4 transcriptional activity;Downregulation of SMAD2/3:SMAD4 transcriptional activity;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;Separation of Sister Chromatids;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);Oncogene Induced Senescence;Regulation of PLK1 Activity at G2/M Transition;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Stimuli-sensing channels;Constitutive Signaling by NOTCH1 HD Domain Mutants;FCERI mediated NF-kB activation;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;NOTCH2 Activation and Transmission of Signal to the Nucleus;Regulation of innate immune responses to cytosolic DNA;Glycogen synthesis;Autodegradation of the E3 ubiquitin ligase COP1;Deactivation of the beta-catenin transactivating complex;Myoclonic epilepsy of Lafora;ABC-family proteins mediated transport;Circadian Clock;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;activated TAK1 mediates p38 MAPK activation;JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Regulation of FZD by ubiquitination;Pink/Parkin Mediated Mitophagy;N-glycan trimming in the ER and Calnexin/Calreticulin cycle;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Hedgehog 'on' state;Negative regulation of FGFR1 signaling;Negative regulation of FGFR2 signaling;Negative regulation of FGFR3 signaling;Negative regulation of FGFR4 signaling;Translesion synthesis by POLK;Translesion synthesis by POLI;Termination of translesion DNA synthesis;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;Negative regulation of MAPK pathway;Regulation of necroptotic cell death;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAP3K8 (TPL2)-dependent MAPK1/3 activation;HDR through Homologous Recombination (HRR);MAPK6/MAPK4 signaling;UCH proteinases;UCH proteinases;Josephin domain DUBs;Ub-specific processing proteases;Ovarian tumor domain proteases;Metalloprotease DUBs;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Processing of DNA double-strand break ends;DNA Damage Recognition in GG-NER;Formation of Incision Complex in GG-NER;Gap-filling DNA repair synthesis and ligation in GG-NER;Dual Incision in GG-NER;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Fanconi Anemia Pathway;Regulation of TP53 Activity through Phosphorylation;Regulation of TP53 Degradation;Regulation of TP53 Activity through Methylation;Negative regulation of MET activity;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;Cyclin D associated events in G1;G2/M Checkpoints;Stabilization of p53;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Downregulation of ERBB2 signaling;Synthesis of active ubiquitin: roles of E1 and E2 enzymes;Synthesis of active ubiquitin: roles of E1 and E2 enzymes;E3 ubiquitin ligases ubiquitinate target proteins;InlB-mediated entry of Listeria monocytogenes into host cell;InlA-mediated entry of Listeria monocytogenes into host cells;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN localization;Regulation of PTEN stability and activity;Neddylation;ER Quality Control Compartment (ERQC);Regulation of expression of SLITs and ROBOs;Regulation of expression of SLITs and ROBOs;NOTCH3 Activation and Transmission of Signal to the Nucleus;NOTCH3 Activation and Transmission of Signal to the Nucleus;TICAM1-dependent activation of IRF3/IRF7;TICAM1,TRAF6-dependent induction of TAK1 complex;Interleukin-1 signaling;Peroxisomal protein import;Peroxisomal protein import;Regulation of signaling by CBL;Endosomal Sorting Complex Required For Transport (ESCRT);Iron uptake and transport;Negative regulators of DDX58/IFIH1 signaling;Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon;IRAK1 recruits IKK complex;IKK complex recruitment mediated by RIP1;IRAK2 mediated activation of TAK1 complex;TRAF6-mediated induction of TAK1 complex within TLR4 complex;Negative regulation of NOTCH4 signaling;TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling;IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation;IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation;Amyloid fiber formation;Antigen processing: Ubiquitination & Proteasome degradation
7317	UBA1	False	True	Synthesis of active ubiquitin: roles of E1 and E2 enzymes;Antigen processing: Ubiquitination & Proteasome degradation
7321	UBE2D1	False	True	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Inactivation of APC/C via direct inhibition of the APC/C complex;TICAM1, RIP1-mediated IKK complex recruitment ;APC/C:Cdc20 mediated degradation of Cyclin B;Autodegradation of Cdh1 by Cdh1:APC/C;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase;Regulation of APC/C activators between G1/S and early anaphase;APC/C:Cdc20 mediated degradation of mitotic proteins;Phosphorylation of the APC/C;APC-Cdc20 mediated degradation of Nek2A;Signaling by BMP;Downstream TCR signaling;Downregulation of SMAD2/3:SMAD4 transcriptional activity;Separation of Sister Chromatids;Senescence-Associated Secretory Phenotype (SASP);FCERI mediated NF-kB activation;CLEC7A (Dectin-1) signaling;Ovarian tumor domain proteases;CDK-mediated phosphorylation and removal of Cdc6;Synthesis of active ubiquitin: roles of E1 and E2 enzymes;E3 ubiquitin ligases ubiquitinate target proteins;Neddylation;Peroxisomal protein import;Negative regulators of DDX58/IFIH1 signaling;IKK complex recruitment mediated by RIP1;Antigen processing: Ubiquitination & Proteasome degradation
7322	UBE2D2	False	True	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;TICAM1, RIP1-mediated IKK complex recruitment ;Downstream TCR signaling;FCERI mediated NF-kB activation;CLEC7A (Dectin-1) signaling;Synthesis of active ubiquitin: roles of E1 and E2 enzymes;E3 ubiquitin ligases ubiquitinate target proteins;Neddylation;Peroxisomal protein import;Negative regulators of DDX58/IFIH1 signaling;IKK complex recruitment mediated by RIP1;Antigen processing: Ubiquitination & Proteasome degradation
7328	UBE2H	False	True	Synthesis of active ubiquitin: roles of E1 and E2 enzymes;Antigen processing: Ubiquitination & Proteasome degradation
7329	UBE2I	False	True	Meiotic synapsis;Vitamin D (calciferol) metabolism;SUMO is transferred from E1 to E2 (UBE2I, UBC9);SUMO is transferred from E1 to E2 (UBE2I, UBC9);SUMOylation of DNA damage response and repair proteins;SUMOylation of transcription factors;SUMOylation of transcription factors;SUMOylation of ubiquitinylation proteins;SUMOylation of transcription cofactors;SUMOylation of transcription cofactors;SUMOylation of SUMOylation proteins;SUMOylation of intracellular receptors;SUMOylation of intracellular receptors;SUMOylation of chromatin organization proteins;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA methylation proteins;SUMOylation of DNA methylation proteins;SUMOylation of immune response proteins;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Processing of DNA double-strand break ends;Formation of Incision Complex in GG-NER;Negative regulation of activity of TFAP2 (AP-2) family transcription factors;Negative regulation of activity of TFAP2 (AP-2) family transcription factors
7332	UBE2L3	False	True	Synthesis of active ubiquitin: roles of E1 and E2 enzymes;E3 ubiquitin ligases ubiquitinate target proteins;Antigen processing: Ubiquitination & Proteasome degradation
7334	UBE2N	False	True	ISG15 antiviral mechanism;NOD1/2 Signaling Pathway;TICAM1, RIP1-mediated IKK complex recruitment ;Downstream TCR signaling;FCERI mediated NF-kB activation;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;activated TAK1 mediates p38 MAPK activation;JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1;CLEC7A (Dectin-1) signaling;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Processing of DNA double-strand break ends;Formation of Incision Complex in GG-NER;G2/M DNA damage checkpoint;E3 ubiquitin ligases ubiquitinate target proteins;Interleukin-1 signaling;IRAK1 recruits IKK complex;IKK complex recruitment mediated by RIP1;TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling;IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation;Antigen processing: Ubiquitination & Proteasome degradation
7335	UBE2V1	False	True	NOD1/2 Signaling Pathway;TICAM1, RIP1-mediated IKK complex recruitment ;Downstream TCR signaling;FCERI mediated NF-kB activation;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;activated TAK1 mediates p38 MAPK activation;JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1;CLEC7A (Dectin-1) signaling;Interleukin-1 signaling;IRAK1 recruits IKK complex;IKK complex recruitment mediated by RIP1;TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling;IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation;Antigen processing: Ubiquitination & Proteasome degradation
7337	UBE3A	False	True	Antigen processing: Ubiquitination & Proteasome degradation
7341	SUMO1	False	True	SUMO is conjugated to E1 (UBA2:SAE1);SUMO is transferred from E1 to E2 (UBE2I, UBC9);SUMO is proteolytically processed;SUMOylation of DNA damage response and repair proteins;SUMOylation of transcription factors;SUMOylation of transcription factors;SUMOylation of ubiquitinylation proteins;SUMOylation of transcription cofactors;SUMOylation of transcription cofactors;SUMOylation of SUMOylation proteins;SUMOylation of intracellular receptors;SUMOylation of intracellular receptors;SUMOylation of chromatin organization proteins;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA methylation proteins;SUMOylation of DNA methylation proteins;SUMOylation of immune response proteins;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Processing of DNA double-strand break ends;Formation of Incision Complex in GG-NER;G2/M DNA damage checkpoint;Regulation of IFNG signaling;Negative regulation of activity of TFAP2 (AP-2) family transcription factors;Negative regulation of activity of TFAP2 (AP-2) family transcription factors
7343	UBTF	False	True	NoRC negatively regulates rRNA expression;RNA Polymerase I Promoter Opening;RNA Polymerase I Transcription Initiation;RNA Polymerase I Promoter Escape;RNA Polymerase I Chain Elongation;RNA Polymerase I Transcription Termination
7345	UCHL1	False	True	UCH proteinases
7347	UCHL3	False	True	UCH proteinases;Synthesis of active ubiquitin: roles of E1 and E2 enzymes;Neddylation
7348	UPK1B	False	True	NA
7353	UFD1L	False	True	Translesion Synthesis by POLH;Ub-specific processing proteases
7358	UGDH	False	True	Formation of the active cofactor, UDP-glucuronate
7372	UMPS	False	True	Pyrimidine biosynthesis
7374	UNG	False	True	Recognition and association of DNA glycosylase with site containing an affected pyrimidine;Cleavage of the damaged pyrimidine ;Displacement of DNA glycosylase by APEX1
7375	USP4	False	True	TNFR1-induced proapoptotic signaling;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;Ub-specific processing proteases
7381	UQCRB	False	True	Respiratory electron transport
7384	UQCRC1	False	True	Respiratory electron transport
7385	UQCRC2	False	True	Respiratory electron transport
7386	UQCRFS1	False	True	Respiratory electron transport
7405	UVRAG	False	True	Macroautophagy
7407	VARS	False	True	Cytosolic tRNA aminoacylation
7408	VASP	False	True	Generation of second messenger molecules;Signaling by ROBO receptors;Signaling by ROBO receptors;Cell-extracellular matrix interactions
7411	VBP1	False	True	Prefoldin mediated transfer of substrate  to CCT/TriC
7414	VCL	True	True	Platelet degranulation ;Smooth Muscle Contraction;MAP2K and MAPK activation;Neutrophil degranulation;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF
7415	VCP	False	True	Translesion Synthesis by POLH;HSF1 activation;ABC-family proteins mediated transport;N-glycan trimming in the ER and Calnexin/Calreticulin cycle;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Defective CFTR causes cystic fibrosis;Josephin domain DUBs;Ovarian tumor domain proteases;Neutrophil degranulation;E3 ubiquitin ligases ubiquitinate target proteins;Protein methylation
7416	VDAC1	False	True	Mitochondrial protein import;Pink/Parkin Mediated Mitophagy;Ub-specific processing proteases;Pyruvate metabolism;Mitochondrial calcium ion transport
7417	VDAC2	False	True	Ub-specific processing proteases;Mitochondrial calcium ion transport
7419	VDAC3	False	True	Ub-specific processing proteases;Mitochondrial calcium ion transport
7421	VDR	False	True	Vitamin D (calciferol) metabolism;Nuclear Receptor transcription pathway;SUMOylation of intracellular receptors
7428	VHL	False	True	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;SUMOylation of ubiquitinylation proteins;Neddylation;Antigen processing: Ubiquitination & Proteasome degradation
7430	EZR	False	True	Netrin-1 signaling;Recycling pathway of L1;Recycling pathway of L1
7431	VIM	False	True	Caspase-mediated cleavage of cytoskeletal proteins;Striated Muscle Contraction;Interleukin-4 and Interleukin-13 signaling
7443	VRK1	False	True	Clearance of Nuclear Envelope Membranes from Chromatin;Initiation of Nuclear Envelope Reformation
7444	VRK2	False	True	Clearance of Nuclear Envelope Membranes from Chromatin;Initiation of Nuclear Envelope Reformation
7448	VTN	False	True	Molecules associated with elastic fibres;Integrin cell surface interactions;Syndecan interactions;ECM proteoglycans;ECM proteoglycans;Regulation of Complement cascade
7453	WARS	False	True	Cytosolic tRNA aminoacylation
7458	EIF4H	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit
7464	CORO2A	False	True	NA
7465	WEE1	False	True	Polo-like kinase mediated events;Cyclin E associated events during G1/S transition ;Cyclin A/B1/B2 associated events during G2/M transition;Cyclin A/B1/B2 associated events during G2/M transition;G2/M DNA replication checkpoint;Cyclin A:Cdk2-associated events at S phase entry;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;Factors involved in megakaryocyte development and platelet production
7466	WFS1	False	True	XBP1(S) activates chaperone genes;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation
7514	XPO1	False	True	Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal;Rev-mediated nuclear export of HIV RNA;NEP/NS2 Interacts with the Cellular Export Machinery;Downregulation of TGF-beta receptor signaling;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;Deactivation of the beta-catenin transactivating complex;HuR (ELAVL1) binds and stabilizes mRNA;RHO GTPases Activate Formins;MAPK6/MAPK4 signaling;Mitotic Prometaphase;Cyclin A/B1/B2 associated events during G2/M transition
7515	XRCC1	False	True	Resolution of AP sites via the single-nucleotide replacement pathway;APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway;HDR through MMEJ (alt-NHEJ);Gap-filling DNA repair synthesis and ligation in GG-NER;Gap-filling DNA repair synthesis and ligation in TC-NER
7517	XRCC3	False	True	HDR through Homologous Recombination (HRR);Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA);Resolution of D-loop Structures through Holliday Junction Intermediates;Homologous DNA Pairing and Strand Exchange
7520	XRCC5	False	True	2-LTR circle formation;Cytosolic sensors of pathogen-associated DNA ;IRF3-mediated induction of type I IFN;Nonhomologous End-Joining (NHEJ);Neutrophil degranulation
7525	YES1	False	True	Signaling by ERBB2;Signaling by SCF-KIT;Signaling by SCF-KIT;Regulation of KIT signaling;FCGR activation;PECAM1 interactions;EPH-Ephrin signaling;CD28 co-stimulation;CTLA4 inhibitory signaling;EPHB-mediated forward signaling;EPHB-mediated forward signaling;EPHA-mediated growth cone collapse;EPHA-mediated growth cone collapse;EPH-ephrin mediated repulsion of cells;RUNX2 regulates osteoblast differentiation;Regulation of signaling by CBL;Regulation of signaling by CBL
7529	YWHAB	False	True	Activation of BAD and translocation to mitochondria ;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Translocation of SLC2A4 (GLUT4) to the plasma membrane;mTOR signalling;mTORC1-mediated signalling;Frs2-mediated activation;ARMS-mediated activation;Signaling by Hippo;Rap1 signalling;Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA;Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA;RHO GTPases activate PKNs;TP53 Regulates Metabolic Genes;RAF activation;MAP2K and MAPK activation;Negative regulation of MAPK pathway;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;Regulation of localization of FOXO transcription factors
7531	YWHAE	True	True	Activation of BAD and translocation to mitochondria ;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Signaling by Hippo;NADE modulates death signalling;Regulation of PLK1 Activity at G2/M Transition;Regulation of HSF1-mediated heat shock response;HSF1 activation;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;RHO GTPases activate PKNs;TP53 Regulates Metabolic Genes;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;AURKA Activation by TPX2;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;RAB GEFs exchange GTP for GDP on RABs
7532	YWHAG	False	True	Activation of BAD and translocation to mitochondria ;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;RHO GTPases activate PKNs;TP53 Regulates Metabolic Genes;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;AURKA Activation by TPX2;Regulation of localization of FOXO transcription factors
7533	YWHAH	False	True	Activation of BAD and translocation to mitochondria ;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Translocation of SLC2A4 (GLUT4) to the plasma membrane;RHO GTPases activate PKNs;TP53 Regulates Metabolic Genes;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
7534	YWHAZ	True	True	Activation of BAD and translocation to mitochondria ;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Deactivation of the beta-catenin transactivating complex;Rap1 signalling;GP1b-IX-V activation signalling;KSRP (KHSRP) binds and destabilizes mRNA;Interleukin-3, Interleukin-5 and GM-CSF signaling;RHO GTPases activate PKNs;TP53 Regulates Metabolic Genes;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;NOTCH4 Activation and Transmission of Signal to the Nucleus;Negative regulation of NOTCH4 signaling;Regulation of localization of FOXO transcription factors
7535	ZAP70	False	True	Translocation of ZAP-70 to Immunological synapse;Generation of second messenger molecules
7536	SF1	False	True	mRNA Splicing - Major Pathway
7542	ZFPL1	False	True	NA
7551	ZNF3	False	True	Generic Transcription Pathway
7597	ZBTB25	False	True	NA
7620	ZNF69	False	True	NA
7625	ZNF74	False	True	Generic Transcription Pathway
7675	NA	False	True	NA
7681	MKRN3	False	True	NA
7690	ZNF131	False	True	SUMOylation of transcription cofactors
7697	ZNF138	False	True	Generic Transcription Pathway
7705	NA	False	True	NA
7709	ZBTB17	False	True	XBP1(S) activates chaperone genes
7726	TRIM26	False	True	Interferon gamma signaling
7737	RNF113A	False	True	NA
7762	NA	False	True	Generic Transcription Pathway
7775	ZNF232	False	True	NA
7780	SLC30A2	False	True	Zinc efflux and compartmentalization by the SLC30 family
7781	SLC30A3	False	True	Zinc efflux and compartmentalization by the SLC30 family
7786	MAP3K12	False	True	NA
7791	ZYX	False	True	NA
7798	NA	False	True	NA
7803	PTP4A1	False	True	NA
7812	CSDE1	False	True	NA
7818	DAP3	False	True	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation elongation;Mitochondrial translation termination
7846	TUBA1A	False	True	Translocation of SLC2A4 (GLUT4) to the plasma membrane;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;Gap junction assembly;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;Regulation of PLK1 Activity at G2/M Transition;HSP90 chaperone cycle for steroid hormone receptors (SHR);Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Prefoldin mediated transfer of substrate  to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Post-chaperonin tubulin folding pathway;Recycling pathway of L1;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Anchoring of the basal body to the plasma membrane;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;AURKA Activation by TPX2;Carboxyterminal post-translational modifications of tubulin;Carboxyterminal post-translational modifications of tubulin;Activation of AMPK downstream of NMDARs;Kinesins
7851	MALL	False	True	NA
7866	IFRD2	False	True	NA
7867	MAPKAPK3	False	True	p38MAPK events;Oxidative Stress Induced Senescence;VEGFA-VEGFR2 Pathway;activated TAK1 mediates p38 MAPK activation
7871	SLMAP	False	True	NA
7874	USP7	False	True	Ub-specific processing proteases;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Regulation of TP53 Degradation;Synthesis of active ubiquitin: roles of E1 and E2 enzymes;Regulation of PTEN localization
7879	RAB7A	False	True	MHC class II antigen presentation;Neutrophil degranulation;TBC/RABGAPs;RAB geranylgeranylation;RAB GEFs exchange GTP for GDP on RABs
7913	DEK	False	True	B-WICH complex positively regulates rRNA expression;Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
7915	ALDH5A1	False	True	Degradation of GABA
7916	PRRC2A	False	True	NA
7917	BAG6	False	True	NA
7919	DDX39B	False	True	Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA 3'-end processing
7936	NELFE	False	True	Formation of RNA Pol II elongation complex ;Formation of the Early Elongation Complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of the HIV-1 Early Elongation Complex;Formation of HIV-1 elongation complex containing HIV-1 Tat;Formation of HIV-1 elongation complex containing HIV-1 Tat;Pausing and recovery of Tat-mediated HIV elongation;Abortive elongation of HIV-1 transcript in the absence of Tat;Tat-mediated HIV elongation arrest and recovery;Tat-mediated elongation of the HIV-1 transcript;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;RNA Polymerase II Pre-transcription Events;TP53 Regulates Transcription of DNA Repair Genes;RNA Polymerase II Transcription Elongation
7957	EPM2A	False	True	Glycogen synthesis;Myoclonic epilepsy of Lafora
7984	ARHGEF5	False	True	NRAGE signals death through JNK;Rho GTPase cycle;G alpha (12/13) signalling events
8021	NUP214	False	True	ISG15 antiviral mechanism;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Rev-mediated nuclear export of HIV RNA;Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Viral Messenger RNA Synthesis;NEP/NS2 Interacts with the Cellular Export Machinery;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;snRNP Assembly;SUMOylation of DNA damage response and repair proteins;SUMOylation of ubiquitinylation proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;SUMOylation of SUMOylation proteins;HuR (ELAVL1) binds and stabilizes mRNA;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins;Transcriptional regulation by small RNAs;tRNA processing in the nucleus
8027	STAM	False	True	EGFR downregulation;Metalloprotease DUBs;Negative regulation of MET activity;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;InlB-mediated entry of Listeria monocytogenes into host cell;Endosomal Sorting Complex Required For Transport (ESCRT)
8078	USP5	False	True	Ub-specific processing proteases;Synthesis of active ubiquitin: roles of E1 and E2 enzymes
8079	MLF2	False	True	NA
8086	AAAS	False	True	ISG15 antiviral mechanism;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Rev-mediated nuclear export of HIV RNA;Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Viral Messenger RNA Synthesis;NEP/NS2 Interacts with the Cellular Export Machinery;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;snRNP Assembly;SUMOylation of DNA damage response and repair proteins;SUMOylation of ubiquitinylation proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;SUMOylation of SUMOylation proteins;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins;Transcriptional regulation by small RNAs;tRNA processing in the nucleus
8087	FXR1	False	True	Signaling by BRAF and RAF fusions
8106	PABPN1	False	True	Cleavage of Growing Transcript in the Termination Region ;Inhibition of Host mRNA Processing and RNA Silencing;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Processing of Intronless Pre-mRNAs
8125	ANP32A	False	True	HuR (ELAVL1) binds and stabilizes mRNA
8131	NPRL3	False	True	NA
8139	GAN	False	True	Neddylation;Antigen processing: Ubiquitination & Proteasome degradation
8148	TAF15	False	True	HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;RNA Polymerase II Pre-transcription Events;Regulation of TP53 Activity through Phosphorylation;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance
8175	SF3A2	False	True	mRNA Splicing - Major Pathway
8187	ZNF239	False	True	NA
8189	SYMPK	False	True	Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA Derived from an Intronless Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Processing of Intronless Pre-mRNAs
8195	MKKS	False	True	BBSome-mediated cargo-targeting to cilium
8202	NCOA3	False	True	PPARA activates gene expression;Transcriptional regulation of white adipocyte differentiation;Transcriptional regulation of white adipocyte differentiation;Activation of anterior HOX genes in hindbrain development during early embryogenesis;MAPK6/MAPK4 signaling;Estrogen-dependent gene expression
8218	CLTCL1	False	True	Gap junction degradation;Formation of annular gap junctions;EPH-ephrin mediated repulsion of cells;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis
8220	DGCR14	False	True	NA
8239	USP9X	False	True	Downregulation of SMAD2/3:SMAD4 transcriptional activity;Ub-specific processing proteases;Synthesis of active ubiquitin: roles of E1 and E2 enzymes;Peroxisomal protein import;Peroxisomal protein import;Amyloid fiber formation
8241	RBM10	False	True	NA
8243	SMC1A	False	True	Meiotic synapsis;Separation of Sister Chromatids;Establishment of Sister Chromatid Cohesion;Cohesin Loading onto Chromatin;Resolution of Sister Chromatid Cohesion;SUMOylation of DNA damage response and repair proteins;Estrogen-dependent gene expression
8266	UBL4A	False	True	NA
8270	LAGE3	False	True	tRNA modification in the nucleus and cytosol
8294	HIST1H4I	False	True	Meiotic synapsis;Packaging Of Telomere Ends;Pre-NOTCH Transcription and Translation;Formation of the beta-catenin:TCF transactivating complex;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;HDACs deacetylate histones;PKMTs methylate histone lysines;HDMs demethylate histones;HATs acetylate histones;HATs acetylate histones;RMTs methylate histone arginines;SIRT1 negatively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;NoRC negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;SUMOylation of chromatin organization proteins;B-WICH complex positively regulates rRNA expression;DNA methylation;Transcriptional regulation by small RNAs;Activation of anterior HOX genes in hindbrain development during early embryogenesis;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Processing of DNA double-strand break ends;Deposition of new CENPA-containing nucleosomes at the centromere;G2/M DNA damage checkpoint;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Estrogen-dependent gene expression;Meiotic recombination;Amyloid fiber formation
8301	PICALM	False	True	Golgi Associated Vesicle Biogenesis;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis
8315	BRAP	False	True	RAF activation;Negative regulation of MAPK pathway;Signaling by moderate kinase activity BRAF mutants;Signaling by RAS mutants;Paradoxical activation of RAF signaling by kinase inactive BRAF
8318	CDC45	False	True	Activation of ATR in response to replication stress;Unwinding of DNA;Activation of E2F1 target genes at G1/S;Activation of the pre-replicative complex
8324	FZD7	False	True	Class B/2 (Secretin family receptors);PCP/CE pathway;PCP/CE pathway;Asymmetric localization of PCP proteins
8335	HIST1H2AB	False	True	Meiotic synapsis;Packaging Of Telomere Ends;Pre-NOTCH Transcription and Translation;Formation of the beta-catenin:TCF transactivating complex;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;HDACs deacetylate histones;HATs acetylate histones;HATs acetylate histones;RMTs methylate histone arginines;SIRT1 negatively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;NoRC negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;B-WICH complex positively regulates rRNA expression;DNA methylation;Transcriptional regulation by small RNAs;Activation of anterior HOX genes in hindbrain development during early embryogenesis;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;UCH proteinases;Ub-specific processing proteases;Metalloprotease DUBs;Deposition of new CENPA-containing nucleosomes at the centromere;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Estrogen-dependent gene expression;Meiotic recombination;Amyloid fiber formation
8339	HIST1H2BG	False	True	Meiotic synapsis;Packaging Of Telomere Ends;Pre-NOTCH Transcription and Translation;Formation of the beta-catenin:TCF transactivating complex;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;HDACs deacetylate histones;HATs acetylate histones;HATs acetylate histones;SIRT1 negatively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;NoRC negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;B-WICH complex positively regulates rRNA expression;DNA methylation;Transcriptional regulation by small RNAs;Activation of anterior HOX genes in hindbrain development during early embryogenesis;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Ub-specific processing proteases;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Processing of DNA double-strand break ends;Deposition of new CENPA-containing nucleosomes at the centromere;G2/M DNA damage checkpoint;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;E3 ubiquitin ligases ubiquitinate target proteins;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Estrogen-dependent gene expression;Meiotic recombination;Amyloid fiber formation
8350	HIST1H3A	False	True	Interleukin-7 signaling;Interleukin-7 signaling;Pre-NOTCH Transcription and Translation;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);HDACs deacetylate histones;PKMTs methylate histone lysines;HDMs demethylate histones;HATs acetylate histones;HATs acetylate histones;RMTs methylate histone arginines;Chromatin modifying enzymes;SIRT1 negatively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;NoRC negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;B-WICH complex positively regulates rRNA expression;DNA methylation;Transcriptional regulation by small RNAs;Activation of anterior HOX genes in hindbrain development during early embryogenesis;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Estrogen-dependent gene expression;Meiotic recombination;Amyloid fiber formation;Factors involved in megakaryocyte development and platelet production
8359	HIST1H4A	False	True	Meiotic synapsis;Packaging Of Telomere Ends;Pre-NOTCH Transcription and Translation;Formation of the beta-catenin:TCF transactivating complex;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;HDACs deacetylate histones;PKMTs methylate histone lysines;HDMs demethylate histones;HATs acetylate histones;HATs acetylate histones;RMTs methylate histone arginines;SIRT1 negatively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;NoRC negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;SUMOylation of chromatin organization proteins;B-WICH complex positively regulates rRNA expression;DNA methylation;Transcriptional regulation by small RNAs;Activation of anterior HOX genes in hindbrain development during early embryogenesis;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Processing of DNA double-strand break ends;Deposition of new CENPA-containing nucleosomes at the centromere;G2/M DNA damage checkpoint;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Estrogen-dependent gene expression;Meiotic recombination;Amyloid fiber formation
8365	NA	False	True	Meiotic synapsis;Packaging Of Telomere Ends;Pre-NOTCH Transcription and Translation;Formation of the beta-catenin:TCF transactivating complex;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;HDACs deacetylate histones;PKMTs methylate histone lysines;HDMs demethylate histones;HATs acetylate histones;HATs acetylate histones;RMTs methylate histone arginines;SIRT1 negatively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;NoRC negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;SUMOylation of chromatin organization proteins;B-WICH complex positively regulates rRNA expression;DNA methylation;Transcriptional regulation by small RNAs;Activation of anterior HOX genes in hindbrain development during early embryogenesis;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Processing of DNA double-strand break ends;Deposition of new CENPA-containing nucleosomes at the centromere;G2/M DNA damage checkpoint;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Estrogen-dependent gene expression;Meiotic recombination;Amyloid fiber formation
8369	HIST1H4G	False	True	NA
8379	MAD1L1	False	True	Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase
8394	PIP5K1A	False	True	Synthesis of PIPs at the plasma membrane;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
8407	TAGLN2	False	True	Platelet degranulation
8417	STX7	False	True	NA
8428	STK24	False	True	Apoptotic cleavage of cellular proteins;Apoptotic execution phase
8443	GNPAT	False	True	Synthesis of PA;Plasmalogen biosynthesis;Peroxisomal protein import;Peroxisomal protein import
8445	DYRK2	False	True	Regulation of TP53 Activity through Phosphorylation
8450	CUL4B	False	True	Recognition of DNA damage by PCNA-containing replication complex;DNA Damage Recognition in GG-NER;Formation of Incision Complex in GG-NER;Dual Incision in GG-NER;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Neddylation
8451	CUL4A	False	True	Recognition of DNA damage by PCNA-containing replication complex;DNA Damage Recognition in GG-NER;Formation of Incision Complex in GG-NER;Dual Incision in GG-NER;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Neddylation
8452	CUL3	False	True	Degradation of DVL;Hedgehog 'on' state;Regulation of RAS by GAPs;Neddylation;Antigen processing: Ubiquitination & Proteasome degradation
8453	CUL2	False	True	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Neddylation;Regulation of expression of SLITs and ROBOs;Antigen processing: Ubiquitination & Proteasome degradation
8454	CUL1	False	True	Activation of NF-kappaB in B cells;Prolactin receptor signaling;SCF-beta-TrCP mediated degradation of Emi1;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;NOTCH1 Intracellular Domain Regulates Transcription;Regulation of PLK1 Activity at G2/M Transition;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling;FCERI mediated NF-kB activation;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Circadian Clock;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;NIK-->noncanonical NF-kB signaling;MAP3K8 (TPL2)-dependent MAPK1/3 activation;Orc1 removal from chromatin;Cyclin D associated events in G1;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Neddylation;Interleukin-1 signaling;Iron uptake and transport;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation
8463	TEAD2	False	True	YAP1- and WWTR1 (TAZ)-stimulated gene expression;RUNX3 regulates YAP1-mediated transcription
8467	SMARCA5	False	True	NoRC negatively regulates rRNA expression;B-WICH complex positively regulates rRNA expression;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Deposition of new CENPA-containing nucleosomes at the centromere
8470	SORBS2	False	True	NA
8471	IRS4	False	True	IRS-related events triggered by IGF1R
8473	OGT	False	True	HATs acetylate histones;UCH proteinases
8480	RAE1	False	True	ISG15 antiviral mechanism;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Rev-mediated nuclear export of HIV RNA;Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Viral Messenger RNA Synthesis;NEP/NS2 Interacts with the Cellular Export Machinery;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;snRNP Assembly;SUMOylation of DNA damage response and repair proteins;SUMOylation of ubiquitinylation proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;SUMOylation of SUMOylation proteins;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins;Transcriptional regulation by small RNAs;tRNA processing in the nucleus
8495	PPFIBP2	False	True	Receptor-type tyrosine-protein phosphatases
8496	PPFIBP1	False	True	Receptor-type tyrosine-protein phosphatases
8498	RANBP3	False	True	NA
8507	ENC1	False	True	NA
8508	NIPSNAP1	False	True	NA
8514	KCNAB2	False	True	Voltage gated Potassium channels;Neutrophil degranulation
8517	IKBKG	False	True	Activation of NF-kappaB in B cells;Activation of NF-kappaB in B cells;ER-Phagosome pathway;NOD1/2 Signaling Pathway;TICAM1, RIP1-mediated IKK complex recruitment ;RIP-mediated NFkB activation via ZBP1;Downstream TCR signaling;FCERI mediated NF-kB activation;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;activated TAK1 mediates p38 MAPK activation;JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1;SUMOylation of immune response proteins;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;IKBKB deficiency causes SCID;IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR);IkBA variant leads to EDA-ID;CLEC7A (Dectin-1) signaling;MAP3K8 (TPL2)-dependent MAPK1/3 activation;Ub-specific processing proteases;Ovarian tumor domain proteases;Interleukin-1 signaling;TRAF6 mediated NF-kB activation;NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10;IRAK1 recruits IKK complex;IKK complex recruitment mediated by RIP1;IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
8520	HAT1	False	True	HATs acetylate histones
8534	CHST1	False	True	Keratan sulfate biosynthesis
8536	CAMK1	False	True	Negative regulation of NMDA receptor-mediated neuronal transmission;Activation of RAC1 downstream of NMDARs;Activation of RAC1 downstream of NMDARs
8539	API5	False	True	NA
8543	LMO4	False	True	NA
8544	PIR	False	True	Digestion
8546	AP3B1	False	True	Golgi Associated Vesicle Biogenesis;Signaling by BRAF and RAF fusions
8550	MAPKAPK5	False	True	Oxidative Stress Induced Senescence;MAPK6/MAPK4 signaling;Regulation of TP53 Activity through Phosphorylation
8559	PRPF18	False	True	NA
8563	THOC5	False	True	Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA 3'-end processing
8565	YARS	False	True	Cytosolic tRNA aminoacylation
8566	PDXK	False	True	Neutrophil degranulation;Vitamins B6 activation to pyridoxal phosphate
8567	MADD	False	True	Regulation of TNFR1 signaling;RAB GEFs exchange GTP for GDP on RABs
8569	MKNK1	False	True	Spry regulation of FGF signaling
8570	KHSRP	False	True	ATF4 activates genes;KSRP (KHSRP) binds and destabilizes mRNA;KSRP (KHSRP) binds and destabilizes mRNA
8574	AKR7A2	False	True	Aflatoxin activation and detoxification
8607	RUVBL1	False	True	Telomere Extension By Telomerase;Formation of the beta-catenin:TCF transactivating complex;Formation of the beta-catenin:TCF transactivating complex;HATs acetylate histones;UCH proteinases;Ub-specific processing proteases;DNA Damage Recognition in GG-NER;Deposition of new CENPA-containing nucleosomes at the centromere
8624	PSMG1	False	True	NA
8626	TP63	False	True	Activation of PUMA and translocation to mitochondria;TP53 Regulates Metabolic Genes;TP53 Regulates Transcription of Genes Involved in Cytochrome C Release;TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain;TP53 Regulates Transcription of Caspase Activators and Caspases;TP53 Regulates Transcription of Death Receptors and Ligands;Regulation of TP53 Activity through Association with Co-factors
8639	AOC3	False	True	Phase I - Functionalization of compounds
8658	TNKS	False	True	TCF dependent signaling in response to WNT;Degradation of AXIN;XAV939 inhibits tankyrase, stabilizing AXIN;Ub-specific processing proteases;Regulation of PTEN stability and activity
8659	ALDH4A1	False	True	Glyoxylate metabolism and glycine degradation;Proline catabolism
8660	IRS2	False	True	PI3K Cascade;IRS-mediated signalling;SOS-mediated signalling;SOS-mediated signalling;PIP3 activates AKT signaling;Interleukin-7 signaling;PI3K/AKT activation;PI3K/AKT activation;Constitutive Signaling by Aberrant PI3K in Cancer;IRS-related events triggered by IGF1R;Signaling by Leptin;RAF/MAP kinase cascade;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;IRS activation;Signal attenuation;RET signaling;Signaling by Erythropoietin;Erythropoietin activates Phosphoinositide-3-kinase (PI3K);Erythropoietin activates Phosphoinositide-3-kinase (PI3K);Erythropoietin activates Phospholipase C gamma (PLCG);Erythropoietin activates STAT5;Erythropoietin activates RAS;Erythropoietin activates RAS;Growth hormone receptor signaling
8661	EIF3A	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit
8662	EIF3B	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit
8663	EIF3C	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit
8664	EIF3D	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit
8666	EIF3G	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit
8667	EIF3H	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit
8668	EIF3I	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit
8672	EIF4G3	False	True	ISG15 antiviral mechanism
8673	VAMP8	False	True	ER-Phagosome pathway;Clathrin derived vesicle budding;Lysosome Vesicle Biogenesis;Golgi Associated Vesicle Biogenesis;Neutrophil degranulation;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis
8674	VAMP4	False	True	Retrograde transport at the Trans-Golgi-Network;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis
8678	BECN1	False	True	Macroautophagy;Ub-specific processing proteases
8683	SRSF9	False	True	Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing
8687	KRT38	False	True	Keratinization;Formation of the cornified envelope
8710	NA	True	False	NA
8711	TNK1	False	True	NA
8724	SNX3	False	True	WNT ligand biogenesis and trafficking;Ub-specific processing proteases
8725	URI1	False	True	NA
8729	GBF1	False	True	Clathrin derived vesicle budding;VxPx cargo-targeting to cilium;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic
8733	GPAA1	False	True	Attachment of GPI anchor to uPAR
8737	RIPK1	False	True	Caspase activation via Death Receptors in the presence of ligand;TICAM1, RIP1-mediated IKK complex recruitment ;RIP-mediated NFkB activation via ZBP1;TRIF-mediated programmed cell death;TRP channels;Regulation by c-FLIP;RIPK1-mediated regulated necrosis;CASP8 activity is inhibited;TNFR1-induced proapoptotic signaling;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;Regulation of necroptotic cell death;Ub-specific processing proteases;Ovarian tumor domain proteases;Dimerization of procaspase-8;TNF signaling;TLR3-mediated TICAM1-dependent programmed cell death;NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10;IKK complex recruitment mediated by RIP1
8742	TNFSF12	False	True	TNFR2 non-canonical NF-kB pathway;TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
8760	CDS2	False	True	Synthesis of PG
8761	PABPC4	False	True	NA
8766	RAB11A	False	True	Translocation of SLC2A4 (GLUT4) to the plasma membrane;Vasopressin regulates renal water homeostasis via Aquaporins;Anchoring of the basal body to the plasma membrane;VxPx cargo-targeting to cilium;TBC/RABGAPs;RAB geranylgeranylation
8775	NAPA	False	True	COPII-mediated vesicle transport;Golgi Associated Vesicle Biogenesis;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;Intra-Golgi traffic;Retrograde transport at the Trans-Golgi-Network
8777	MPDZ	False	True	NA
8786	RGS11	False	True	G alpha (i) signalling events;G alpha (i) signalling events;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
8794	TNFRSF10C	False	True	TP53 Regulates Transcription of Death Receptors and Ligands
8798	DYRK4	False	True	NA
8799	PEX11B	False	True	NA
8804	CREG1	False	True	Neutrophil degranulation
8805	TRIM24	False	True	Signaling by cytosolic FGFR1 fusion mutants;Signaling by FGFR1 in disease;Signaling by BRAF and RAF fusions
8815	BANF1	False	True	Integration of provirus;2-LTR circle formation;Integration of viral DNA into host genomic DNA;Autointegration results in viral DNA circles;APOBEC3G mediated resistance to HIV-1 infection;Vpr-mediated nuclear import of PICs;Clearance of Nuclear Envelope Membranes from Chromatin;Initiation of Nuclear Envelope Reformation
8826	IQGAP1	False	True	Nephrin family interactions;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;RHO GTPases activate IQGAPs;MAP2K and MAPK activation;Neutrophil degranulation;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF
8833	GMPS	False	True	Purine ribonucleoside monophosphate biosynthesis
8834	TMEM11	False	True	Cristae formation
8836	GGH	True	True	Neutrophil degranulation
8837	CFLAR	False	True	Regulation by c-FLIP;RIPK1-mediated regulated necrosis;CASP8 activity is inhibited;Dimerization of procaspase-8;TRAIL  signaling
8844	KSR1	False	True	RAF activation;MAP2K and MAPK activation;Negative regulation of MAPK pathway;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF
8848	TSC22D1	False	True	NA
8856	NR1I2	False	True	Nuclear Receptor transcription pathway;SUMOylation of intracellular receptors
8857	NA	True	False	NA
8862	APLN	False	True	Peptide ligand-binding receptors;G alpha (i) signalling events
8871	SYNJ2	False	True	Synthesis of PIPs at the plasma membrane;Clathrin-mediated endocytosis
8872	CDC123	False	True	NA
8874	ARHGEF7	False	True	EGFR downregulation;NRAGE signals death through JNK;Rho GTPase cycle;Ephrin signaling;G alpha (12/13) signalling events;Activation of RAC1 downstream of NMDARs
8878	SQSTM1	False	True	NRIF signals cell death from the nucleus;p75NTR recruits signalling complexes;NF-kB is activated and signals survival;Pink/Parkin Mediated Mitophagy;Interleukin-1 signaling
8880	FUBP1	False	True	NA
8882	ZPR1	False	True	NA
8886	DDX18	False	True	NA
8888	MCM3AP	False	True	NA
8894	EIF2S2	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;ABC-family proteins mediated transport;Translation initiation complex formation;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Recycling of eIF2:GDP
8899	PRPF4B	False	True	NA
8907	AP1M1	False	True	Nef mediated downregulation of MHC class I complex cell surface expression;MHC class II antigen presentation;Lysosome Vesicle Biogenesis;Golgi Associated Vesicle Biogenesis;Neutrophil degranulation
8911	NA	False	True	NCAM1 interactions
8914	TIMELESS	False	True	Processing of DNA double-strand break ends
8925	HERC1	False	True	Antigen processing: Ubiquitination & Proteasome degradation
8943	AP3D1	False	True	NA
8945	BTRC	False	True	Activation of NF-kappaB in B cells;Prolactin receptor signaling;SCF-beta-TrCP mediated degradation of Emi1;Vpu mediated degradation of CD4;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of PLK1 Activity at G2/M Transition;FCERI mediated NF-kB activation;Deactivation of the beta-catenin transactivating complex;Circadian Clock;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;NIK-->noncanonical NF-kB signaling;MAP3K8 (TPL2)-dependent MAPK1/3 activation;Neddylation;Interleukin-1 signaling;Antigen processing: Ubiquitination & Proteasome degradation
8971	H1FX	False	True	NA
8976	WASL	False	True	Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;NOSTRIN mediated eNOS trafficking;Nephrin family interactions;EPHB-mediated forward signaling;EPHB-mediated forward signaling;DCC mediated attractive signaling;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs;Clathrin-mediated endocytosis
8985	PLOD3	False	True	Collagen biosynthesis and modifying enzymes
9020	MAP3K14	False	True	CD28 dependent PI3K/Akt signaling;Dectin-1 mediated noncanonical NF-kB signaling;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
9022	CLIC3	False	True	NA
9025	RNF8	False	True	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Processing of DNA double-strand break ends;G2/M DNA damage checkpoint
9026	HIP1R	False	True	Golgi Associated Vesicle Biogenesis;Clathrin-mediated endocytosis
9027	NA	False	True	Amyloid fiber formation
9031	BAZ1B	False	True	B-WICH complex positively regulates rRNA expression;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
9039	UBA3	False	True	Dectin-1 mediated noncanonical NF-kB signaling;NIK-->noncanonical NF-kB signaling;Neddylation;Antigen processing: Ubiquitination & Proteasome degradation
9040	UBE2M	False	True	TGF-beta receptor signaling activates SMADs;Dectin-1 mediated noncanonical NF-kB signaling;NIK-->noncanonical NF-kB signaling;Neddylation;Antigen processing: Ubiquitination & Proteasome degradation
9044	BTAF1	False	True	NA
9045	RPL14	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
9049	AIP	False	True	Aryl hydrocarbon receptor signalling;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
9052	GPRC5A	False	True	NA
9054	NFS1	False	True	Mitochondrial iron-sulfur cluster biogenesis;Molybdenum cofactor biosynthesis
9061	PAPSS1	False	True	Transport and synthesis of PAPS;Metabolism of ingested H2SeO4 and H2SeO3 into H2Se;Signaling by BRAF and RAF fusions
9063	PIAS2	False	True	SUMOylation of DNA damage response and repair proteins;SUMOylation of transcription factors;SUMOylation of ubiquitinylation proteins;SUMOylation of transcription cofactors;SUMOylation of intracellular receptors;SUMOylation of intracellular receptors;SUMOylation of chromatin organization proteins;Activation of anterior HOX genes in hindbrain development during early embryogenesis
9064	MAP3K6	False	True	NA
9071	CLDN10	False	True	Tight junction interactions
9092	SART1	False	True	mRNA Splicing - Major Pathway
9093	DNAJA3	False	True	NA
9094	UNC119	False	True	NA
9097	USP14	False	True	Ub-specific processing proteases
9099	USP2	False	True	TNFR1-induced proapoptotic signaling;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;Ub-specific processing proteases;Regulation of TP53 Degradation
9101	USP8	False	True	Downregulation of ERBB2:ERBB3 signaling;Regulation of FZD by ubiquitination;Ub-specific processing proteases;Negative regulation of MET activity
9104	RGN	False	True	NA
9111	NMI	False	True	NA
9118	NA	False	True	NA
9124	PDLIM1	False	True	NA
9131	AIFM1	False	True	NA
9132	KCNQ4	False	True	Voltage gated Potassium channels
9135	RABEP1	False	True	TBC/RABGAPs
9141	PDCD5	False	True	NA
9145	SYNGR1	False	True	Neutrophil degranulation
9146	HGS	False	True	EGFR downregulation;Lysosome Vesicle Biogenesis;Ub-specific processing proteases;Negative regulation of MET activity;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;InlB-mediated entry of Listeria monocytogenes into host cell;Endosomal Sorting Complex Required For Transport (ESCRT)
9149	DYRK1B	False	True	NA
9156	EXO1	False	True	Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha);Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta);HDR through Single Strand Annealing (SSA);HDR through Homologous Recombination (HRR);Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA);Resolution of D-loop Structures through Holliday Junction Intermediates;Homologous DNA Pairing and Strand Exchange;Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;Regulation of TP53 Activity through Phosphorylation;G2/M DNA damage checkpoint
9180	OSMR	False	True	IL-6-type cytokine receptor ligand interactions
9181	ARHGEF2	False	True	NRAGE signals death through JNK;Rho GTPase cycle;G alpha (12/13) signalling events
9182	RASSF9	False	True	NA
9188	DDX21	False	True	B-WICH complex positively regulates rRNA expression;Major pathway of rRNA processing in the nucleolus and cytosol
9191	DEDD	False	True	NA
9200	PTPLA	False	True	Synthesis of very long-chain fatty acyl-CoAs
9203	ZMYM3	False	True	NA
9204	NA	False	True	NA
9208	LRRFIP1	False	True	Signaling by cytosolic FGFR1 fusion mutants;LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production;Signaling by FGFR1 in disease
9209	LRRFIP2	False	True	NA
9212	AURKB	False	True	Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;SUMOylation of DNA replication proteins;RHO GTPases Activate Formins;Regulation of TP53 Activity through Phosphorylation;Mitotic Prometaphase;Regulation of MECP2 expression and activity
9218	VAPA	False	True	Sphingolipid de novo biosynthesis;Neutrophil degranulation
9221	NOLC1	False	True	NA
9223	MAGI1	False	True	NA
9230	RAB11B	False	True	TBC/RABGAPs;RAB geranylgeranylation
9238	TBRG4	False	True	NA
9240	PNMA1	False	True	NA
9244	CRLF1	False	True	IL-6-type cytokine receptor ligand interactions;Interleukin-27 signaling
9252	RPS6KA5	False	True	ERK/MAPK targets;CREB phosphorylation;NCAM signaling for neurite out-growth;Recycling pathway of L1;CD209 (DC-SIGN) signaling
9261	MAPKAPK2	False	True	p38MAPK events;CREB phosphorylation;Synthesis of Leukotrienes (LT) and Eoxins (EX);Oxidative Stress Induced Senescence;Regulation of HSF1-mediated heat shock response;VEGFA-VEGFR2 Pathway;activated TAK1 mediates p38 MAPK activation;Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA;Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
9262	STK17B	False	True	NA
9266	CYTH2	False	True	Intra-Golgi traffic
9271	PIWIL1	False	True	PIWI-interacting RNA (piRNA) biogenesis
9275	BCL7B	False	True	NA
9296	ATP6V1F	False	True	ROS, RNS production in phagocytes;Insulin receptor recycling;Transferrin endocytosis and recycling;Ion channel transport
9306	SOCS6	False	True	Regulation of KIT signaling;Neddylation
9320	TRIP12	False	True	Antigen processing: Ubiquitination & Proteasome degradation
9321	TRIP11	False	True	Intraflagellar transport;Intra-Golgi traffic
9330	GTF3C3	False	True	RNA Polymerase III Abortive And Retractive Initiation;RNA Polymerase III Transcription Initiation From Type 1 Promoter;RNA Polymerase III Transcription Initiation From Type 1 Promoter;RNA Polymerase III Transcription Initiation From Type 2 Promoter;RNA Polymerase III Transcription Initiation From Type 2 Promoter
9341	VAMP3	False	True	ER-Phagosome pathway;Retrograde transport at the Trans-Golgi-Network;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis
9343	EFTUD2	False	True	mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway
9349	RPL23	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
9352	TXNL1	False	True	NA
9361	LONP1	False	True	NA
9367	RAB9A	False	True	Retrograde transport at the Trans-Golgi-Network;RAB geranylgeranylation;RAB GEFs exchange GTP for GDP on RABs
9373	PLAA	False	True	NA
9380	GRHPR	False	True	Glyoxylate metabolism and glycine degradation
9382	COG1	False	True	COPI-mediated anterograde transport;Intra-Golgi traffic;Retrograde transport at the Trans-Golgi-Network
9400	RECQL5	False	True	NA
9402	GRAP2	False	True	Signaling by SCF-KIT;Generation of second messenger molecules;DAP12 signaling;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;FCERI mediated Ca+2 mobilization;CD28 co-stimulation
9404	LPXN	False	True	NA
9406	ZRANB2	False	True	NA
9410	SNRNP40	False	True	mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway
9413	FAM189A2	False	True	NA
9414	TJP2	False	True	Signaling by Hippo;Apoptotic cleavage of cell adhesion  proteins
9416	DDX23	False	True	mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway
9445	ITM2B	False	True	Amyloid fiber formation
9446	GSTO1	False	True	Methylation;Glutathione conjugation;Vitamin C (ascorbate) metabolism;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
9448	MAP4K4	False	True	Oxidative Stress Induced Senescence
9451	EIF2AK3	False	True	PERK regulates gene expression
9467	SH3BP5	False	True	NA
9470	EIF4E2	False	True	ISG15 antiviral mechanism
9474	ATG5	False	True	Macroautophagy;Macroautophagy;Pink/Parkin Mediated Mitophagy;Receptor Mediated Mitophagy;Negative regulators of DDX58/IFIH1 signaling
9475	ROCK2	False	True	EPHB-mediated forward signaling;EPHB-mediated forward signaling;EPHA-mediated growth cone collapse;G alpha (12/13) signalling events;Sema4D induced cell migration and growth-cone collapse;Sema4D induced cell migration and growth-cone collapse;VEGFA-VEGFR2 Pathway;RHO GTPases Activate ROCKs;RHO GTPases Activate ROCKs
9482	STX8	False	True	NA
9491	PSMF1	False	True	Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation
9493	KIF23	False	True	MHC class II antigen presentation;COPI-dependent Golgi-to-ER retrograde traffic;Mitotic Telophase/Cytokinesis;Kinesins
9512	PMPCB	False	True	Mitochondrial protein import;Processing of SMDT1
9520	NPEPPS	False	True	Antigen processing: Ubiquitination & Proteasome degradation
9522	SCAMP1	False	True	Neutrophil degranulation
9524	TECR	False	True	Synthesis of very long-chain fatty acyl-CoAs
9529	BAG5	False	True	Regulation of HSF1-mediated heat shock response
9530	BAG4	False	True	Regulation of HSF1-mediated heat shock response;Signaling by FGFR1 in disease;TNF signaling;Signaling by plasma membrane FGFR1 fusions
9531	BAG3	False	True	Regulation of HSF1-mediated heat shock response
9532	BAG2	False	True	Regulation of HSF1-mediated heat shock response
9547	CXCL14	False	True	NA
9551	ATP5J2	False	True	Formation of ATP by chemiosmotic coupling;Cristae formation
9554	SEC22B	False	True	ER-Phagosome pathway;COPII-mediated vesicle transport;Cargo concentration in the ER;COPI-dependent Golgi-to-ER retrograde traffic
9555	H2AFY	False	True	NA
9557	CHD1L	False	True	Formation of Incision Complex in GG-NER;Dual Incision in GG-NER
9564	BCAR1	False	True	Downstream signal transduction;p130Cas linkage to MAPK signaling for integrins;VEGFA-VEGFR2 Pathway;VEGFA-VEGFR2 Pathway;PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
9570	GOSR2	False	True	COPII-mediated vesicle transport;XBP1(S) activates chaperone genes;Cargo concentration in the ER;COPI-mediated anterograde transport;Intra-Golgi traffic
9584	RBM39	False	True	NA
9586	CREB5	False	True	NA
9587	MAD2L1BP	False	True	NA
9588	PRDX6	False	True	Detoxification of Reactive Oxygen Species;Neutrophil degranulation
9601	PDIA4	False	True	NA
9612	NCOR2	False	True	PPARA activates gene expression;NOTCH1 Intracellular Domain Regulates Transcription;Downregulation of SMAD2/3:SMAD4 transcriptional activity;Downregulation of SMAD2/3:SMAD4 transcriptional activity;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;HDACs deacetylate histones;Transcriptional regulation of white adipocyte differentiation;Transcriptional regulation of white adipocyte differentiation;SUMOylation of transcription cofactors;Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha);Loss of MECP2 binding ability to the NCoR/SMRT complex;Regulation of MECP2 expression and activity
9628	RGS6	False	True	G alpha (i) signalling events;G alpha (i) signalling events;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
9631	NUP155	False	True	ISG15 antiviral mechanism;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Rev-mediated nuclear export of HIV RNA;Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Viral Messenger RNA Synthesis;NEP/NS2 Interacts with the Cellular Export Machinery;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;snRNP Assembly;SUMOylation of DNA damage response and repair proteins;SUMOylation of ubiquitinylation proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;SUMOylation of SUMOylation proteins;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins;Transcriptional regulation by small RNAs;tRNA processing in the nucleus
9632	SEC24C	False	True	Regulation of cholesterol biosynthesis by SREBP (SREBF);COPII-mediated vesicle transport;MHC class II antigen presentation;Cargo concentration in the ER;Antigen Presentation: Folding, assembly and peptide loading of class I MHC
9635	CLCA2	False	True	Stimuli-sensing channels
9636	ISG15	False	True	ISG15 antiviral mechanism;NS1 Mediated Effects on Host Pathways;DDX58/IFIH1-mediated induction of interferon-alpha/beta;Termination of translesion DNA synthesis;Interferon alpha/beta signaling;Negative regulators of DDX58/IFIH1 signaling
9641	IKBKE	False	True	SUMOylation of immune response proteins;TICAM1-dependent activation of IRF3/IRF7;TRAF3-dependent IRF activation pathway;TRAF6 mediated IRF7 activation;Negative regulators of DDX58/IFIH1 signaling;Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
9647	PPM1F	False	True	Negative regulation of NMDA receptor-mediated neuronal transmission
9650	NA	False	True	NA
9656	MDC1	False	True	SUMOylation of DNA damage response and repair proteins;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Processing of DNA double-strand break ends;TP53 Regulates Transcription of DNA Repair Genes;G2/M DNA damage checkpoint
9669	EIF5B	False	True	GTP hydrolysis and joining of the 60S ribosomal subunit
9673	SLC25A44	False	True	NA
9681	DEPDC5	False	True	NA
9685	CLINT1	False	True	Golgi Associated Vesicle Biogenesis
9688	NUP93	False	True	ISG15 antiviral mechanism;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Rev-mediated nuclear export of HIV RNA;Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Viral Messenger RNA Synthesis;NEP/NS2 Interacts with the Cellular Export Machinery;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;snRNP Assembly;SUMOylation of DNA damage response and repair proteins;SUMOylation of ubiquitinylation proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;SUMOylation of SUMOylation proteins;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins;Transcriptional regulation by small RNAs;tRNA processing in the nucleus
9689	BZW1	False	True	NA
9698	PUM1	False	True	Golgi Associated Vesicle Biogenesis
9702	CEP57	False	True	Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;AURKA Activation by TPX2
9711	KIAA0226	False	True	NA
9721	GPRIN2	False	True	NA
9729	KIAA0408	False	True	NA
9734	HDAC9	False	True	NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
9743	ARHGAP32	False	True	Rho GTPase cycle
9750	FAM65B	False	True	NA
9753	ZSCAN12	False	True	NA
9757	KMT2B	False	True	PKMTs methylate histone lysines;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
9759	HDAC4	False	True	NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;SUMOylation of intracellular receptors;SUMOylation of chromatin organization proteins;RUNX2 regulates chondrocyte maturation;RUNX3 regulates p14-ARF
9772	NA	False	True	NA
9775	EIF4A3	False	True	Cleavage of Growing Transcript in the Termination Region ;ISG15 antiviral mechanism;Transport of Mature mRNA derived from an Intron-Containing Transcript;Deadenylation of mRNA;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
9777	TM9SF4	False	True	NA
9778	KIAA0232	False	True	NA
9782	MATR3	False	True	NA
9787	DLGAP5	False	True	NOTCH3 Intracellular Domain Regulates Transcription
9790	BMS1	False	True	rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol
9793	CKAP5	False	True	Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;RHO GTPases Activate Formins;Mitotic Prometaphase;AURKA Activation by TPX2
9798	IST1	False	True	Neutrophil degranulation
9810	RNF40	False	True	E3 ubiquitin ligases ubiquitinate target proteins
9815	GIT2	False	True	NA
9816	NA	False	True	NA
9817	KEAP1	False	True	Ub-specific processing proteases;Neddylation;Antigen processing: Ubiquitination & Proteasome degradation
9824	NA	False	True	Rho GTPase cycle
9828	NA	False	True	NRAGE signals death through JNK;Rho GTPase cycle;G alpha (12/13) signalling events
9836	LCMT2	False	True	Synthesis of wybutosine at G37 of tRNA(Phe);Synthesis of wybutosine at G37 of tRNA(Phe)
9846	GAB2	False	True	PI3K Cascade;Signaling by SCF-KIT;Signaling by cytosolic FGFR1 fusion mutants;Role of LAT2/NTAL/LAB on calcium mobilization;Role of LAT2/NTAL/LAB on calcium mobilization;RET signaling;Interleukin-15 signaling;Interleukin receptor SHC signaling
9847	NA	False	True	Translocation of SLC2A4 (GLUT4) to the plasma membrane
9849	ZNF518A	False	True	NA
9859	CEP170	False	True	NA
9861	PSMD6	False	True	Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation
9868	TOMM70A	False	True	Mitochondrial protein import;Pink/Parkin Mediated Mitophagy;Ub-specific processing proteases
9869	SETDB1	False	True	PKMTs methylate histone lysines
9870	AREL1	False	True	Antigen processing: Ubiquitination & Proteasome degradation
9874	TLK1	False	True	NA
9877	NA	False	True	Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA 3'-end processing
9878	TOX4	False	True	NA
9879	DDX46	False	True	mRNA Splicing - Major Pathway
9882	TBC1D4	False	True	Translocation of SLC2A4 (GLUT4) to the plasma membrane
9883	POM121	False	True	ISG15 antiviral mechanism;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Rev-mediated nuclear export of HIV RNA;Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Viral Messenger RNA Synthesis;NEP/NS2 Interacts with the Cellular Export Machinery;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;snRNP Assembly;SUMOylation of DNA damage response and repair proteins;SUMOylation of ubiquitinylation proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;SUMOylation of SUMOylation proteins;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins;Transcriptional regulation by small RNAs;tRNA processing in the nucleus
9886	RHOBTB1	False	True	Rho GTPase cycle
9889	ZBED4	False	True	NA
9894	TELO2	False	True	NA
9897	KIAA0196	False	True	NA
9908	G3BP2	False	True	NA
9918	NCAPD2	False	True	Condensation of Prometaphase Chromosomes;Condensation of Prometaphase Chromosomes
9919	SEC16A	False	True	COPII-mediated vesicle transport
9921	RNF10	False	True	NA
9939	RBM8A	False	True	Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
9948	WDR1	False	True	Platelet degranulation
9958	USP15	False	True	Downregulation of TGF-beta receptor signaling;UCH proteinases;Ub-specific processing proteases
9961	MVP	False	True	Neutrophil degranulation
9967	THRAP3	False	True	PPARA activates gene expression;Transcriptional regulation of white adipocyte differentiation;Transcriptional regulation of white adipocyte differentiation
9970	NR1I3	False	True	Nuclear Receptor transcription pathway
9972	NUP153	False	True	ISG15 antiviral mechanism;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Rev-mediated nuclear export of HIV RNA;Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Viral Messenger RNA Synthesis;NEP/NS2 Interacts with the Cellular Export Machinery;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;snRNP Assembly;SUMOylation of DNA damage response and repair proteins;SUMOylation of ubiquitinylation proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;SUMOylation of SUMOylation proteins;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins;Transcriptional regulation by small RNAs;tRNA processing in the nucleus
9973	CCS	False	True	Detoxification of Reactive Oxygen Species;Detoxification of Reactive Oxygen Species
9978	RBX1	False	True	Recognition of DNA damage by PCNA-containing replication complex;Prolactin receptor signaling;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Vif-mediated degradation of APOBEC3G;Degradation of beta-catenin by the destruction complex;NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Degradation of DVL;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;DNA Damage Recognition in GG-NER;Formation of Incision Complex in GG-NER;Dual Incision in GG-NER;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Orc1 removal from chromatin;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation
9987	HNRNPDL	False	True	Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
9997	SCO2	False	True	TP53 Regulates Metabolic Genes;Respiratory electron transport
10009	ZBTB33	False	True	NA
10013	HDAC6	False	True	NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;HSF1 activation;Cilium Assembly;Transcriptional regulation by RUNX2;RUNX2 regulates osteoblast differentiation
10015	PDCD6IP	False	True	Budding and maturation of HIV virion;Uptake and function of anthrax toxins
10016	PDCD6	False	True	NA
10026	PIGK	False	True	Attachment of GPI anchor to uPAR
10036	CHAF1A	False	True	NA
10040	TOM1L1	False	True	NA
10045	SH2D3A	False	True	NA
10048	RANBP9	False	True	L1CAM interactions;RAF/MAP kinase cascade;MET activates RAS signaling
10049	DNAJB6	False	True	Regulation of HSF1-mediated heat shock response
10051	SMC4	False	True	Condensation of Prophase Chromosomes;Condensation of Prometaphase Chromosomes;Condensation of Prometaphase Chromosomes
10054	UBA2	False	True	SUMO is conjugated to E1 (UBA2:SAE1);SUMO is conjugated to E1 (UBA2:SAE1);SUMO is transferred from E1 to E2 (UBE2I, UBC9);SUMO is transferred from E1 to E2 (UBE2I, UBC9)
10055	SAE1	False	True	SUMO is conjugated to E1 (UBA2:SAE1);SUMO is conjugated to E1 (UBA2:SAE1);SUMO is transferred from E1 to E2 (UBE2I, UBC9);SUMO is transferred from E1 to E2 (UBE2I, UBC9)
10056	FARSB	False	True	Cytosolic tRNA aminoacylation
10059	DNM1L	False	True	Apoptotic execution phase
10060	NA	False	True	ATP sensitive Potassium channels;ABC-family proteins mediated transport;Ion homeostasis;Defective ABCC9 causes dilated cardiomyopathy 10, familial atrial fibrillation 12 and hypertrichotic osteochondrodysplasia
10062	NR1H3	False	True	PPARA activates gene expression;Nuclear Receptor transcription pathway;SUMOylation of intracellular receptors;VLDLR internalisation and degradation
10063	COX17	False	True	Mitochondrial protein import
10075	HUWE1	False	True	Neutrophil degranulation;Antigen processing: Ubiquitination & Proteasome degradation
10092	ARPC5	False	True	Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;EPHB-mediated forward signaling;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs;Neutrophil degranulation;Clathrin-mediated endocytosis
10093	ARPC4	True	True	Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;EPHB-mediated forward signaling;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs;Clathrin-mediated endocytosis
10094	ARPC3	False	True	Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;EPHB-mediated forward signaling;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs;Clathrin-mediated endocytosis
10095	ARPC1B	False	True	Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;EPHB-mediated forward signaling;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs
10096	ACTR3	False	True	Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;EPHB-mediated forward signaling;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs;Clathrin-mediated endocytosis
10097	ACTR2	True	True	Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;EPHB-mediated forward signaling;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs;Neutrophil degranulation;Clathrin-mediated endocytosis
10100	TSPAN2	False	True	NA
10105	PPIF	False	True	NA
10107	TRIM10	False	True	Interferon gamma signaling
10109	ARPC2	False	True	Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;EPHB-mediated forward signaling;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs;Clathrin-mediated endocytosis
10110	SGK2	False	True	Stimuli-sensing channels
10113	PREB	False	True	COPII-mediated vesicle transport;XBP1(S) activates chaperone genes;Cargo concentration in the ER
10128	LRPPRC	False	True	TP53 Regulates Metabolic Genes;Respiratory electron transport
10130	PDIA6	False	True	XBP1(S) activates chaperone genes;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation
10131	TRAP1	False	True	Respiratory electron transport
10133	OPTN	False	True	Regulation of PLK1 Activity at G2/M Transition;TBC/RABGAPs
10134	BCAP31	False	True	Apoptotic cleavage of cellular proteins;Apoptotic execution phase;Antigen Presentation: Folding, assembly and peptide loading of class I MHC
10135	NAMPT	False	True	BMAL1:CLOCK,NPAS2 activates circadian gene expression;Nicotinamide salvaging
10141	LINC01587	False	True	NA
10146	G3BP1	False	True	NA
10150	MBNL2	False	True	NA
10152	ABI2	False	True	Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;VEGFA-VEGFR2 Pathway;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs
10155	TRIM28	False	True	Generic Transcription Pathway;SUMOylation of transcription cofactors
10165	SLC25A13	False	True	Mitochondrial protein import;Gluconeogenesis
10168	ZNF197	False	True	Generic Transcription Pathway
10169	SERF2	False	True	NA
10174	SORBS3	False	True	Smooth Muscle Contraction
10180	RBM6	False	True	NA
10181	RBM5	False	True	mRNA Splicing - Major Pathway
10188	TNK2	False	True	NA
10189	ALYREF	False	True	Cleavage of Growing Transcript in the Termination Region ;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing
10190	TXNDC9	False	True	NA
10195	ALG3	False	True	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein;Defective ALG3 causes ALG3-CDG (CDG-1d)
10197	PSME3	False	True	Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation
10198	NA	False	True	NA
10200	MPHOSPH6	False	True	Major pathway of rRNA processing in the nucleolus and cytosol
10204	NUTF2	False	True	NA
10211	FLOT1	False	True	Synaptic adhesion-like molecules
10213	PSMD14	False	True	Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;Metalloprotease DUBs;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation
10226	PLIN3	False	True	Triglyceride catabolism;Retrograde transport at the Trans-Golgi-Network
10228	STX6	False	True	Intra-Golgi traffic;Retrograde transport at the Trans-Golgi-Network
10236	HNRNPR	False	True	mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA
10238	DCAF7	False	True	Association of TriC/CCT with target proteins during biosynthesis;Neddylation
10250	SRRM1	False	True	Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing
10260	DENND4A	False	True	RAB GEFs exchange GTP for GDP on RABs
10270	AKAP8	False	True	NA
10273	STUB1	False	True	Downregulation of TGF-beta receptor signaling;Downregulation of ERBB2 signaling;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity;Antigen processing: Ubiquitination & Proteasome degradation
10283	CWC27	False	True	mRNA Splicing - Major Pathway
10284	SAP18	False	True	HDACs deacetylate histones;NoRC negatively regulates rRNA expression
10286	BCAS2	False	True	mRNA Splicing - Major Pathway
10291	SF3A1	False	True	mRNA Splicing - Major Pathway
10294	DNAJA2	False	True	HSP90 chaperone cycle for steroid hormone receptors (SHR)
10298	PAK4	False	True	Activation of RAC1
10309	NA	False	True	NA
10313	RTN3	False	True	Synaptic adhesion-like molecules
10319	LAMC3	False	True	Laminin interactions;Laminin interactions;Non-integrin membrane-ECM interactions;MET activates PTK2 signaling
10327	AKR1A1	False	True	Glutathione conjugation;Formation of xylulose-5-phosphate
10336	PCGF3	False	True	NA
10342	TFG	False	True	COPII-mediated vesicle transport
10350	NA	False	True	ABC transporters in lipid homeostasis
10362	HMG20B	False	True	HDACs deacetylate histones;Factors involved in megakaryocyte development and platelet production
10367	MICU1	False	True	Mitochondrial calcium ion transport;Processing of SMDT1
10376	TUBA1B	True	True	Translocation of SLC2A4 (GLUT4) to the plasma membrane;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;Gap junction assembly;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HSP90 chaperone cycle for steroid hormone receptors (SHR);Recruitment of NuMA to mitotic centrosomes;Formation of tubulin folding intermediates by CCT/TriC;Post-chaperonin tubulin folding pathway;Recycling pathway of L1;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;Carboxyterminal post-translational modifications of tubulin;Carboxyterminal post-translational modifications of tubulin;Activation of AMPK downstream of NMDARs;Kinesins
10381	TUBB3	False	True	Translocation of SLC2A4 (GLUT4) to the plasma membrane;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;Gap junction assembly;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HSP90 chaperone cycle for steroid hormone receptors (SHR);Recruitment of NuMA to mitotic centrosomes;Prefoldin mediated transfer of substrate  to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Post-chaperonin tubulin folding pathway;Recycling pathway of L1;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;Carboxyterminal post-translational modifications of tubulin;Carboxyterminal post-translational modifications of tubulin;Activation of AMPK downstream of NMDARs;Kinesins
10383	TUBB4B	True	True	Translocation of SLC2A4 (GLUT4) to the plasma membrane;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;Gap junction assembly;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;Regulation of PLK1 Activity at G2/M Transition;HSP90 chaperone cycle for steroid hormone receptors (SHR);Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Prefoldin mediated transfer of substrate  to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Post-chaperonin tubulin folding pathway;Recycling pathway of L1;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Anchoring of the basal body to the plasma membrane;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;Neutrophil degranulation;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;AURKA Activation by TPX2;Carboxyterminal post-translational modifications of tubulin;Carboxyterminal post-translational modifications of tubulin;Activation of AMPK downstream of NMDARs;Kinesins
10385	BTN2A2	False	True	Butyrophilin (BTN) family interactions
10389	SCML2	False	True	NA
10391	CORO2B	False	True	NA
10398	MYL9	False	True	EPHA-mediated growth cone collapse;Sema4D induced cell migration and growth-cone collapse;Smooth Muscle Contraction;RHO GTPases activate PKNs;RHO GTPases activate CIT;RHO GTPases Activate ROCKs;RHO GTPases activate PAKs;RHO GTPases activate PAKs;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
10399	GNB2L1	False	True	Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;TNFR1-mediated ceramide production
10403	NDC80	False	True	Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase
10406	WFDC2	False	True	NA
10409	BASP1	False	True	NA
10413	YAP1	False	True	Nuclear signaling by ERBB4;Signaling by Hippo;YAP1- and WWTR1 (TAZ)-stimulated gene expression;RUNX1 regulates transcription of genes involved in differentiation of HSCs;RUNX2 regulates osteoblast differentiation;RUNX3 regulates YAP1-mediated transcription
10419	PRMT5	False	True	snRNP Assembly;RMTs methylate histone arginines;Regulation of TP53 Activity through Methylation
10420	TESK2	False	True	NA
10421	CD2BP2	False	True	mRNA Splicing - Major Pathway
10424	NA	False	True	NA
10432	RBM14	False	True	RUNX2 regulates bone development
10444	ZER1	False	True	NA
10447	FAM3C	False	True	Platelet degranulation
10449	ACAA2	False	True	Mitochondrial Fatty Acid Beta-Oxidation
10452	TOMM40	False	True	Mitochondrial protein import;Pink/Parkin Mediated Mitophagy
10454	TAB1	False	True	NOD1/2 Signaling Pathway;FCERI mediated NF-kB activation;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;activated TAK1 mediates p38 MAPK activation;JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1;TNFR1-induced NFkappaB signaling pathway;CLEC7A (Dectin-1) signaling;Ub-specific processing proteases;TICAM1,TRAF6-dependent induction of TAK1 complex;Interleukin-1 signaling;IRAK2 mediated activation of TAK1 complex;TRAF6-mediated induction of TAK1 complex within TLR4 complex;IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
10458	BAIAP2	False	True	Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;VEGFA-VEGFR2 Pathway;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs
10460	TACC3	False	True	NOTCH3 Activation and Transmission of Signal to the Nucleus;Negative regulation of NOTCH4 signaling
10461	MERTK	False	True	Cell surface interactions at the vascular wall
10468	FST	False	True	Antagonism of Activin by Follistatin
10469	TIMM44	False	True	Mitochondrial protein import
10475	TRIM38	False	True	Interferon gamma signaling
10476	ATP5H	False	True	Formation of ATP by chemiosmotic coupling;Cristae formation
10480	EIF3M	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit
10486	CAP2	False	True	Role of ABL in ROBO-SLIT signaling
10488	CREB3	False	True	CREB3 factors activate genes;CREB3 factors activate genes
10490	VTI1B	False	True	Platelet degranulation
10491	CRTAP	False	True	Collagen biosynthesis and modifying enzymes
10492	SYNCRIP	False	True	NA
10493	VAT1	False	True	Neutrophil degranulation
10498	CARM1	False	True	RORA activates gene expression;BMAL1:CLOCK,NPAS2 activates circadian gene expression;PPARA activates gene expression;PPARA activates gene expression;Transcriptional activation of mitochondrial biogenesis;Activation of gene expression by SREBF (SREBP);RMTs methylate histone arginines;Transcriptional regulation of white adipocyte differentiation;Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha);Circadian Clock;TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest;Estrogen-dependent gene expression
10513	APPBP2	False	True	NA
10514	MYBBP1A	False	True	B-WICH complex positively regulates rRNA expression
10521	DDX17	False	True	SUMOylation of transcription cofactors
10523	CHERP	False	True	mRNA Splicing - Major Pathway
10524	KAT5	False	True	Formation of the beta-catenin:TCF transactivating complex;Formation of the beta-catenin:TCF transactivating complex;DNA Damage/Telomere Stress Induced Senescence;HATs acetylate histones;HDR through Single Strand Annealing (SSA);HDR through Homologous Recombination (HRR);Sensing of DNA Double Strand Breaks;Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA);Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Resolution of D-loop Structures through Holliday Junction Intermediates;Nonhomologous End-Joining (NHEJ);Homologous DNA Pairing and Strand Exchange;Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;Regulation of TP53 Activity through Phosphorylation;G2/M DNA damage checkpoint;Estrogen-dependent gene expression
10525	HYOU1	False	True	Scavenging by Class F Receptors;Scavenging by Class F Receptors;XBP1(S) activates chaperone genes
10526	IPO8	False	True	Transcriptional regulation by small RNAs
10527	IPO7	False	True	NA
10528	NOP56	False	True	Association of TriC/CCT with target proteins during biosynthesis;rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol
10531	PITRM1	False	True	Mitochondrial protein import
10540	DCTN2	False	True	MHC class II antigen presentation;Regulation of PLK1 Activity at G2/M Transition;HSP90 chaperone cycle for steroid hormone receptors (SHR);Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;COPI-mediated anterograde transport;COPI-independent Golgi-to-ER retrograde traffic;AURKA Activation by TPX2
10542	LAMTOR5	False	True	Macroautophagy;mTOR signalling;mTORC1-mediated signalling;Energy dependent regulation of mTOR by LKB1-AMPK;TP53 Regulates Metabolic Genes;Regulation of PTEN gene transcription
10544	PROCR	False	True	Common Pathway of Fibrin Clot Formation;Cell surface interactions at the vascular wall
10549	PRDX4	False	True	Neutrophil degranulation
10552	ARPC1A	False	True	Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;EPHB-mediated forward signaling;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs;Clathrin-mediated endocytosis
10559	SLC35A1	False	True	Sialic acid metabolism;Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F);Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F);Transport of nucleotide sugars
10567	RABAC1	False	True	NA
10569	SLU7	False	True	Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing
10570	DPYSL4	False	True	CRMPs in Sema3A signaling
10573	MRPL28	False	True	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation elongation;Mitochondrial translation termination
10574	CCT7	False	True	Prefoldin mediated transfer of substrate  to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Folding of actin by CCT/TriC;Association of TriC/CCT with target proteins during biosynthesis;Association of TriC/CCT with target proteins during biosynthesis;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
10575	CCT4	False	True	Prefoldin mediated transfer of substrate  to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Folding of actin by CCT/TriC;Association of TriC/CCT with target proteins during biosynthesis;Association of TriC/CCT with target proteins during biosynthesis;BBSome-mediated cargo-targeting to cilium;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
10576	CCT2	False	True	Prefoldin mediated transfer of substrate  to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Folding of actin by CCT/TriC;Association of TriC/CCT with target proteins during biosynthesis;Association of TriC/CCT with target proteins during biosynthesis;BBSome-mediated cargo-targeting to cilium;Neutrophil degranulation;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
10577	NPC2	True	True	Neutrophil degranulation;LDL clearance
10580	SORBS1	False	True	Smooth Muscle Contraction
10584	COLEC10	False	True	Lectin pathway of complement activation;Initial triggering of complement
10591	DNPH1	False	True	Purine catabolism
10594	PRPF8	False	True	mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway
10598	AHSA1	False	True	NA
10607	TBL3	False	True	rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol
10611	PDLIM5	False	True	Neurexins and neuroligins
10616	RBCK1	False	True	Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;Antigen processing: Ubiquitination & Proteasome degradation
10618	TGOLN2	False	True	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Golgi Associated Vesicle Biogenesis;Retrograde transport at the Trans-Golgi-Network;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Post-translational protein phosphorylation
10625	IVNS1ABP	False	True	NA
10627	MYL12A	False	True	EPHA-mediated growth cone collapse;Ephrin signaling;Sema4D induced cell migration and growth-cone collapse;Smooth Muscle Contraction;RHO GTPases activate PKNs;RHO GTPases activate CIT;RHO GTPases Activate ROCKs;RHO GTPases activate PAKs;RHO GTPases activate PAKs
10628	TXNIP	False	True	The NLRP3 inflammasome;The NLRP3 inflammasome;Regulation of FOXO transcriptional activity by acetylation
10641	NPRL2	False	True	NA
10645	CAMKK2	False	True	CaMK IV-mediated phosphorylation of CREB;CaMK IV-mediated phosphorylation of CREB;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;Activation of RAC1 downstream of NMDARs;Activation of RAC1 downstream of NMDARs;Activation of AMPK downstream of NMDARs
10650	NA	False	True	TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
10652	YKT6	False	True	COPII-mediated vesicle transport;COPI-mediated anterograde transport;Intra-Golgi traffic
10656	KHDRBS3	False	True	PTK6 Regulates Proteins Involved in RNA Processing
10667	FARS2	False	True	Mitochondrial tRNA aminoacylation
10671	DCTN6	False	True	MHC class II antigen presentation;HSP90 chaperone cycle for steroid hormone receptors (SHR);COPI-mediated anterograde transport;COPI-independent Golgi-to-ER retrograde traffic
10682	EBP	False	True	Cholesterol biosynthesis via desmosterol;Cholesterol biosynthesis via lathosterol
10687	PNMA2	False	True	NA
10693	CCT6B	False	True	Prefoldin mediated transfer of substrate  to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Folding of actin by CCT/TriC;Association of TriC/CCT with target proteins during biosynthesis;Association of TriC/CCT with target proteins during biosynthesis;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
10694	CCT8	False	True	Prefoldin mediated transfer of substrate  to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Folding of actin by CCT/TriC;Association of TriC/CCT with target proteins during biosynthesis;Association of TriC/CCT with target proteins during biosynthesis;BBSome-mediated cargo-targeting to cilium;Neutrophil degranulation;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
10726	NUDC	False	True	Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Mitotic Telophase/Cytokinesis
10728	PTGES3	False	True	Synthesis of Prostaglandins (PG) and Thromboxanes (TX);HSP90 chaperone cycle for steroid hormone receptors (SHR);HSF1 activation;Attenuation phase;Aryl hydrocarbon receptor signalling;ESR-mediated signaling;Estrogen-dependent gene expression
10733	PLK4	False	True	Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;AURKA Activation by TPX2
10745	PHTF1	False	True	NA
10746	MAP3K2	False	True	NA
10749	KIF1C	False	True	COPI-dependent Golgi-to-ER retrograde traffic;Kinesins
10762	NUP50	False	True	ISG15 antiviral mechanism;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Rev-mediated nuclear export of HIV RNA;Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Viral Messenger RNA Synthesis;NEP/NS2 Interacts with the Cellular Export Machinery;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;snRNP Assembly;SUMOylation of DNA damage response and repair proteins;SUMOylation of ubiquitinylation proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;SUMOylation of SUMOylation proteins;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins;Transcriptional regulation by small RNAs;tRNA processing in the nucleus
10763	NES	False	True	NA
10768	AHCYL1	False	True	PLC beta mediated events;DAG and IP3 signaling;Role of phospholipids in phagocytosis;FCERI mediated Ca+2 mobilization;Regulation of insulin secretion;VEGFR2 mediated cell proliferation;Ion homeostasis;Ion homeostasis;CLEC7A (Dectin-1) induces NFAT activation;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
10772	SRSF10	False	True	mRNA Splicing - Major Pathway
10783	NEK6	False	True	Activation of NIMA Kinases NEK9, NEK6, NEK7;Nuclear Pore Complex (NPC) Disassembly
10785	WDR4	False	True	tRNA modification in the nucleus and cytosol
10787	NCKAP1	False	True	Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;VEGFA-VEGFR2 Pathway;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs
10791	NA	False	True	NA
10797	MTHFD2	False	True	Metabolism of folate and pterines
10801	SEPT9	False	True	NA
10802	SEC24A	False	True	Regulation of cholesterol biosynthesis by SREBP (SREBF);COPII-mediated vesicle transport;MHC class II antigen presentation;Cargo concentration in the ER;Antigen Presentation: Folding, assembly and peptide loading of class I MHC
10808	HSPH1	False	True	Scavenging by Class F Receptors;Scavenging by Class F Receptors;Regulation of HSF1-mediated heat shock response
10826	NA	False	True	NA
10845	CLPX	False	True	NA
10856	RUVBL2	False	True	Telomere Extension By Telomerase;HATs acetylate histones
10868	USP20	False	True	Ub-specific processing proteases
10869	USP19	False	True	Ub-specific processing proteases
10890	RAB10	False	True	Translocation of SLC2A4 (GLUT4) to the plasma membrane;Neutrophil degranulation;RAB geranylgeranylation;RAB GEFs exchange GTP for GDP on RABs
10906	TRAFD1	False	True	NA
10907	TXNL4A	False	True	mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway
10910	SUGT1	False	True	The NLRP3 inflammasome
10912	GADD45G	False	True	NA
10914	PAPOLA	False	True	Cleavage of Growing Transcript in the Termination Region ;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Processing of Intronless Pre-mRNAs
10916	MAGED2	False	True	Platelet degranulation
10921	RNPS1	False	True	Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
10922	FASTK	False	True	NA
10923	SUB1	False	True	NA
10927	SPIN1	False	True	NA
10928	RALBP1	False	True	Rho GTPase cycle
10929	SRSF8	False	True	NA
10933	MORF4L1	False	True	HATs acetylate histones
10935	PRDX3	False	True	Detoxification of Reactive Oxygen Species
10938	EHD1	False	True	Factors involved in megakaryocyte development and platelet production
10946	SF3A3	False	True	mRNA Splicing - Major Pathway
10948	STARD3	False	True	Pregnenolone biosynthesis
10949	HNRNPA0	False	True	mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA
10951	CBX1	False	True	NA
10953	TOMM34	False	True	NA
10956	OS9	False	True	ABC-family proteins mediated transport;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Defective CFTR causes cystic fibrosis;ER Quality Control Compartment (ERQC)
10963	STIP1	False	True	HSP90 chaperone cycle for steroid hormone receptors (SHR)
10970	CKAP4	False	True	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Surfactant metabolism;Neutrophil degranulation;Post-translational protein phosphorylation
10971	YWHAQ	False	True	Activation of BAD and translocation to mitochondria ;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Translocation of SLC2A4 (GLUT4) to the plasma membrane;RHO GTPases activate PKNs;TP53 Regulates Metabolic Genes;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;Regulation of localization of FOXO transcription factors
10973	ASCC3	False	True	ALKBH3 mediated reversal of alkylation damage
10979	FERMT2	False	True	Cell-extracellular matrix interactions
10980	COPS6	False	True	DNA Damage Recognition in GG-NER;Formation of TC-NER Pre-Incision Complex;Cargo recognition for clathrin-mediated endocytosis;Neddylation
10982	MAPRE2	False	True	NA
10985	GCN1L1	False	True	NA
10987	COPS5	False	True	DNA Damage Recognition in GG-NER;Formation of TC-NER Pre-Incision Complex;Cargo recognition for clathrin-mediated endocytosis;Neddylation
10988	METAP2	False	True	Inactivation, recovery and regulation of the phototransduction cascade
10989	IMMT	False	True	Cristae formation
10992	SF3B2	False	True	mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway
11007	CCDC85B	False	True	NA
11009	IL24	False	True	Interleukin-20 family signaling
11010	GLIPR1	False	True	PPARA activates gene expression;Neutrophil degranulation
11030	RBPMS	False	True	NA
11034	DSTN	False	True	NA
11040	PIM2	False	True	NA
11047	ADRM1	False	True	UCH proteinases;Ub-specific processing proteases
11052	CPSF6	False	True	Signaling by cytosolic FGFR1 fusion mutants;Signaling by FGFR1 in disease
11059	WWP1	False	True	Downregulation of ERBB4 signaling;Stimuli-sensing channels;Regulation of RUNX2 expression and activity;Antigen processing: Ubiquitination & Proteasome degradation
11067	C10orf10	False	True	NA
11068	CYB561D2	False	True	NA
11078	TRIOBP	False	True	NA
11079	RER1	False	True	NA
11080	DNAJB4	False	True	NA
11091	WDR5	False	True	PKMTs methylate histone lysines;HATs acetylate histones;HATs acetylate histones;RMTs methylate histone arginines;Activation of anterior HOX genes in hindbrain development during early embryogenesis;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Neddylation
11100	HNRNPUL1	False	True	mRNA Splicing - Major Pathway
11103	KRR1	False	True	rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol
11124	FAF1	False	True	NA
11133	KPTN	False	True	NA
11136	SLC7A9	False	True	Basigin interactions;Amino acid transport across the plasma membrane;Defective SLC7A9 causes cystinuria (CSNU)
11140	CDC37	False	True	Signaling by ERBB2;Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants;Constitutive Signaling by EGFRvIII;Downregulation of ERBB2 signaling
11144	DMC1	False	True	Meiotic recombination
11146	GLMN	False	True	Antigen processing: Ubiquitination & Proteasome degradation
11149	BVES	False	True	NA
11155	LDB3	False	True	NA
11160	ERLIN2	False	True	ABC-family proteins mediated transport;Signaling by FGFR1 in disease;Defective CFTR causes cystic fibrosis;Signaling by plasma membrane FGFR1 fusions
11161	NA	False	True	NA
11170	FAM107A	False	True	NA
11184	MAP4K1	False	True	NA
11187	PKP3	False	True	Keratinization;Formation of the cornified envelope
11190	CEP250	False	True	Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;AURKA Activation by TPX2
11198	SUPT16H	False	True	Formation of RNA Pol II elongation complex ;Formation of HIV elongation complex in the absence of HIV Tat;Formation of HIV-1 elongation complex containing HIV-1 Tat;Pausing and recovery of Tat-mediated HIV elongation;Tat-mediated HIV elongation arrest and recovery;Tat-mediated elongation of the HIV-1 transcript;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;RNA Polymerase II Pre-transcription Events;TP53 Regulates Transcription of DNA Repair Genes;Regulation of TP53 Activity through Phosphorylation;RNA Polymerase II Transcription Elongation
11212	PROSC	False	True	NA
11213	IRAK3	False	True	MyD88:MAL(TIRAP) cascade initiated on plasma membrane;Interleukin-1 signaling
11217	AKAP2	False	True	NA
11222	MRPL3	False	True	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation elongation;Mitochondrial translation termination
11224	RPL35	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
11226	GALNT6	False	True	O-linked glycosylation of mucins
11228	RASSF8	False	True	NA
11235	PDCD10	False	True	NA
11243	PMF1	False	True	Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase
11244	ZHX1	False	True	NA
11267	SNF8	False	True	Endosomal Sorting Complex Required For Transport (ESCRT)
11269	DDX19B	False	True	NA
11284	PNKP	False	True	APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
11285	B4GALT7	False	True	A tetrasaccharide linker sequence is required for GAG synthesis;Defective B4GALT7 causes EDS, progeroid type
11313	LYPLA2	False	True	L1CAM interactions
11315	PARK7	False	True	SUMOylation of transcription cofactors
11325	DDX42	False	True	mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway
11329	STK38	False	True	NA
11331	PHB2	False	True	Processing of SMDT1
11332	ACOT7	False	True	Mitochondrial Fatty Acid Beta-Oxidation
11333	PDAP1	False	True	Neutrophil degranulation
11335	CBX3	False	True	ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;RNA Polymerase I Chain Elongation;Transcriptional Regulation by E2F6
11338	U2AF2	False	True	Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing
11339	OIP5	False	True	Deposition of new CENPA-containing nucleosomes at the centromere
11343	MGLL	False	True	Acyl chain remodeling of DAG and TAG;Triglyceride catabolism;Arachidonate production from DAG
11344	TWF2	False	True	NA
11346	SYNPO	False	True	NA
11622	NA	False	True	NA
12460	NA	False	True	NA
12550	Cdh1	False	True	NA
13505	NA	False	True	NA
13510	NA	False	True	NA
14828	Hspa5	False	True	NA
15481	NA	False	True	NA
15502	NA	False	True	NA
15505	Hsph1	False	True	NA
15511	NA	False	True	NA
15512	NA	False	True	NA
15525	NA	False	True	NA
17248	Mdm4	False	True	NA
17279	Melk	False	True	NA
18415	NA	False	True	NA
19015	Ppard	False	True	NA
19016	Pparg	False	True	NA
20655	Sod1	False	True	NA
22802	NA	False	True	Stimuli-sensing channels
22803	XRN2	False	True	Association of TriC/CCT with target proteins during biosynthesis;Major pathway of rRNA processing in the nucleolus and cytosol
22818	COPZ1	False	True	COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic
22820	COPG1	False	True	COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic
22822	PHLDA1	False	True	Interaction between PHLDA1 and AURKA
22824	HSPA4L	False	True	Regulation of HSF1-mediated heat shock response
22826	DNAJC8	False	True	mRNA Splicing - Major Pathway
22827	PUF60	False	True	mRNA Splicing - Major Pathway
22828	NA	False	True	NA
22832	CEP162	False	True	Anchoring of the basal body to the plasma membrane
22837	COBLL1	False	True	NA
22841	RAB11FIP2	False	True	Vasopressin regulates renal water homeostasis via Aquaporins
22848	AAK1	False	True	Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis
22858	ICK	False	True	NA
22859	NA	False	True	NA
22868	FASTKD2	False	True	NA
22872	SEC31A	False	True	COPII-mediated vesicle transport;MHC class II antigen presentation;XBP1(S) activates chaperone genes;Antigen Presentation: Folding, assembly and peptide loading of class I MHC
22882	ZHX2	False	True	NA
22907	DHX30	False	True	NA
22908	SACM1L	False	True	Synthesis of PIPs at the ER membrane;Synthesis of PIPs at the Golgi membrane
22913	RALY	False	True	NA
22919	MAPRE1	False	True	Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;RHO GTPases Activate Formins;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;AURKA Activation by TPX2
22931	RAB18	False	True	Neutrophil degranulation;COPI-independent Golgi-to-ER retrograde traffic;RAB geranylgeranylation;RAB GEFs exchange GTP for GDP on RABs
22938	SNW1	False	True	Pre-NOTCH Transcription and Translation;Pre-NOTCH Transcription and Translation;Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells;NOTCH1 Intracellular Domain Regulates Transcription;NOTCH1 Intracellular Domain Regulates Transcription;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Notch-HLH transcription pathway;mRNA Splicing - Major Pathway;RUNX3 regulates NOTCH signaling;RUNX3 regulates NOTCH signaling;NOTCH3 Intracellular Domain Regulates Transcription;NOTCH3 Intracellular Domain Regulates Transcription;NOTCH4 Intracellular Domain Regulates Transcription
22948	CCT5	False	True	Prefoldin mediated transfer of substrate  to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Folding of actin by CCT/TriC;Association of TriC/CCT with target proteins during biosynthesis;Association of TriC/CCT with target proteins during biosynthesis;BBSome-mediated cargo-targeting to cilium;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
22954	TRIM32	False	True	Regulation of innate immune responses to cytosolic DNA;Antigen processing: Ubiquitination & Proteasome degradation
22974	TPX2	False	True	Regulation of TP53 Activity through Phosphorylation;AURKA Activation by TPX2
22980	TCF25	False	True	NA
22981	NINL	False	True	Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;AURKA Activation by TPX2
22985	ACIN1	False	True	Apoptotic cleavage of cellular proteins
22992	KDM2A	False	True	HDMs demethylate histones
22994	CEP131	False	True	Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;AURKA Activation by TPX2
22995	CEP152	False	True	Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;AURKA Activation by TPX2
22998	LIMCH1	False	True	NA
23011	RAB21	False	True	RAB geranylgeranylation;RAB GEFs exchange GTP for GDP on RABs
23012	STK38L	False	True	NA
23015	NA	False	True	NA
23019	CNOT1	False	True	Deadenylation of mRNA;TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
23020	SNRNP200	False	True	mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway
23022	PALLD	False	True	NA
23028	KDM1A	False	True	HDACs deacetylate histones;HDMs demethylate histones;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Regulation of PTEN gene transcription;Estrogen-dependent gene expression;Factors involved in megakaryocyte development and platelet production
23031	MAST3	False	True	NA
23036	NA	False	True	NA
23039	XPO7	False	True	NA
23042	PDXDC1	False	True	NA
23047	PDS5B	False	True	Separation of Sister Chromatids;Establishment of Sister Chromatid Cohesion;Cohesin Loading onto Chromatin;Resolution of Sister Chromatid Cohesion
23052	ENDOD1	False	True	Platelet degranulation
23064	SETX	False	True	NA
23072	HECW1	False	True	Degradation of DVL
23074	NA	False	True	NA
23076	RRP1B	False	True	NA
23077	MYCBP2	False	True	NA
23087	TRIM35	False	True	Interferon gamma signaling
23090	ZNF423	False	True	NA
23094	NA	False	True	NA
23095	KIF1B	False	True	COPI-dependent Golgi-to-ER retrograde traffic;Kinesins
23098	SARM1	False	True	MyD88-independent TLR4 cascade ;Toll Like Receptor 3 (TLR3) Cascade;Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon;IKK complex recruitment mediated by RIP1;TRAF6-mediated induction of TAK1 complex within TLR4 complex
23099	ZBTB43	False	True	NA
23108	NA	False	True	Rap1 signalling
23118	TAB2	False	True	Nuclear signaling by ERBB4;Nuclear signaling by ERBB4;NOD1/2 Signaling Pathway;Downstream TCR signaling;FCERI mediated NF-kB activation;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;activated TAK1 mediates p38 MAPK activation;JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1;TNFR1-induced NFkappaB signaling pathway;CLEC7A (Dectin-1) signaling;TICAM1,TRAF6-dependent induction of TAK1 complex;Interleukin-1 signaling;IRAK2 mediated activation of TAK1 complex;TRAF6-mediated induction of TAK1 complex within TLR4 complex;IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
23122	CLASP2	False	True	Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;Role of ABL in ROBO-SLIT signaling;RHO GTPases Activate Formins;Mitotic Prometaphase
23126	POGZ	False	True	NA
23132	RAD54L2	False	True	NA
23136	EPB41L3	False	True	Neurexins and neuroligins
23139	MAST2	False	True	NA
23157	SEPT6	False	True	NA
23164	MPRIP	False	True	Signaling by BRAF and RAF fusions
23165	NUP205	False	True	ISG15 antiviral mechanism;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Rev-mediated nuclear export of HIV RNA;Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Viral Messenger RNA Synthesis;NEP/NS2 Interacts with the Cellular Export Machinery;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;snRNP Assembly;SUMOylation of DNA damage response and repair proteins;SUMOylation of ubiquitinylation proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;SUMOylation of SUMOylation proteins;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins;Transcriptional regulation by small RNAs;tRNA processing in the nucleus
23171	GPD1L	False	True	Synthesis of PA
23178	PASK	False	True	NA
23185	NA	False	True	NA
23189	NA	False	True	Estrogen-dependent gene expression
23191	CYFIP1	False	True	Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;VEGFA-VEGFR2 Pathway;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs;Neutrophil degranulation
23193	GANAB	False	True	N-glycan trimming in the ER and Calnexin/Calreticulin cycle;Calnexin/calreticulin cycle
23197	FAF2	False	True	Neutrophil degranulation
23198	PSME4	False	True	Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Antigen processing: Ubiquitination & Proteasome degradation
23203	PMPCA	False	True	Mitochondrial protein import;Processing of SMDT1
23204	ARL6IP1	False	True	NA
23211	NA	False	True	NA
23214	XPO6	False	True	NA
23216	TBC1D1	False	True	Translocation of SLC2A4 (GLUT4) to the plasma membrane;Translocation of SLC2A4 (GLUT4) to the plasma membrane
23218	NA	False	True	Neutrophil degranulation
23219	FBXO28	False	True	NA
23220	DTX4	False	True	IRF3 mediated activation of type 1 IFN;Activated NOTCH1 Transmits Signal to the Nucleus;Activated NOTCH1 Transmits Signal to the Nucleus;Regulation of innate immune responses to cytosolic DNA;IRF3-mediated induction of type I IFN
23221	RHOBTB2	False	True	Rho GTPase cycle
23224	SYNE2	False	True	Meiotic synapsis
23225	NUP210	False	True	ISG15 antiviral mechanism;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Rev-mediated nuclear export of HIV RNA;Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Viral Messenger RNA Synthesis;NEP/NS2 Interacts with the Cellular Export Machinery;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;snRNP Assembly;SUMOylation of DNA damage response and repair proteins;SUMOylation of ubiquitinylation proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;SUMOylation of SUMOylation proteins;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins;Transcriptional regulation by small RNAs;tRNA processing in the nucleus
23234	DNAJC9	False	True	NA
23237	ARC	False	True	NA
23242	COBL	False	True	NA
23244	PDS5A	False	True	Separation of Sister Chromatids;Establishment of Sister Chromatid Cohesion;Cohesin Loading onto Chromatin;Resolution of Sister Chromatid Cohesion
23248	NA	False	True	RNA polymerase II transcribes snRNA genes;RNA polymerase II transcribes snRNA genes
23255	MTCL1	False	True	NA
23261	NA	False	True	NA
23262	PPIP5K2	False	True	Synthesis of pyrophosphates in the cytosol
23264	ZC3H7B	False	True	NA
23276	KLHL18	False	True	NA
23281	MTUS2	False	True	NA
23288	IQCE	False	True	Activation of SMO
23291	FBXW11	False	True	Activation of NF-kappaB in B cells;Downstream TCR signaling;Regulation of PLK1 Activity at G2/M Transition;FCERI mediated NF-kB activation;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;NIK-->noncanonical NF-kB signaling;MAP3K8 (TPL2)-dependent MAPK1/3 activation;Neddylation;Antigen processing: Ubiquitination & Proteasome degradation
23294	ANKS1A	False	True	NA
23303	KIF13B	False	True	COPI-dependent Golgi-to-ER retrograde traffic;Kinesins
23306	TMEM194A	False	True	NA
23310	NCAPD3	False	True	Condensation of Prophase Chromosomes
23313	KIAA0930	False	True	NA
23315	NA	False	True	Sodium/Proton exchangers
23317	DNAJC13	False	True	Neutrophil degranulation
23321	TRIM2	False	True	Interferon gamma signaling
23326	USP22	False	True	HATs acetylate histones;Ub-specific processing proteases
23327	NEDD4L	False	True	Budding and maturation of HIV virion;Downregulation of TGF-beta receptor signaling;Downregulation of SMAD2/3:SMAD4 transcriptional activity;Stimuli-sensing channels;Antigen processing: Ubiquitination & Proteasome degradation
23328	SASH1	False	True	NA
23332	CLASP1	False	True	Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Role of ABL in ROBO-SLIT signaling;Anchoring of the basal body to the plasma membrane;RHO GTPases Activate Formins;Mitotic Prometaphase;AURKA Activation by TPX2
23333	NA	False	True	NA
23334	SZT2	False	True	NA
23345	SYNE1	False	True	Meiotic synapsis
23350	U2SURP	False	True	mRNA Splicing - Major Pathway
23358	USP24	False	True	Ub-specific processing proteases
23361	NA	False	True	NA
23363	OBSL1	False	True	Neddylation
23367	LARP1	False	True	NA
23373	CRTC1	False	True	Transcriptional activation of mitochondrial biogenesis;Circadian Clock;Circadian Clock
23380	SRGAP2	False	True	Rho GTPase cycle;Inactivation of CDC42 and RAC1;RHO GTPases Activate Formins
23384	NA	False	True	NA
23385	NCSTN	False	True	Nuclear signaling by ERBB4;Degradation of the extracellular matrix;Regulated proteolysis of p75NTR;NRIF signals cell death from the nucleus;Activated NOTCH1 Transmits Signal to the Nucleus;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;NOTCH2 Activation and Transmission of Signal to the Nucleus;EPH-ephrin mediated repulsion of cells;Neutrophil degranulation;NOTCH3 Activation and Transmission of Signal to the Nucleus;NOTCH4 Activation and Transmission of Signal to the Nucleus;Noncanonical activation of NOTCH3;Amyloid fiber formation
23386	NUDCD3	False	True	NA
23387	SIK3	False	True	NA
23392	KIAA0368	False	True	NA
23397	NCAPH	False	True	Condensation of Prometaphase Chromosomes;Condensation of Prometaphase Chromosomes
23400	ATP13A2	False	True	Ion transport by P-type ATPases
23405	DICER1	False	True	MicroRNA (miRNA) biogenesis;Small interfering RNA (siRNA) biogenesis
23411	SIRT1	False	True	Regulation of HSF1-mediated heat shock response;Circadian Clock;SIRT1 negatively regulates rRNA expression;SIRT1 negatively regulates rRNA expression;Regulation of FOXO transcriptional activity by acetylation;Regulation of FOXO transcriptional activity by acetylation
23418	NA	False	True	NA
23429	RYBP	False	True	RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known;Transcriptional Regulation by E2F6
23431	AP4E1	False	True	Lysosome Vesicle Biogenesis;Golgi Associated Vesicle Biogenesis
23435	TARDBP	False	True	NA
23446	NA	False	True	Synthesis of PC;Transport of bile salts and organic acids, metal ions and amine compounds;Choline catabolism
23450	SF3B3	False	True	mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway
23451	SF3B1	False	True	B-WICH complex positively regulates rRNA expression;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway
23468	CBX5	False	True	SUMOylation of chromatin organization proteins;Transcriptional Regulation by E2F6;Factors involved in megakaryocyte development and platelet production
23469	NA	False	True	NA
23476	BRD4	False	True	NA
23479	ISCU	False	True	Mitochondrial iron-sulfur cluster biogenesis
23481	PES1	False	True	Major pathway of rRNA processing in the nucleolus and cytosol
23484	NA	False	True	NA
23499	MACF1	False	True	NA
23503	ZFYVE26	False	True	NA
23509	POFUT1	False	True	Pre-NOTCH Processing in the Endoplasmic Reticulum
23513	SCRIB	False	True	Asymmetric localization of PCP proteins
23517	SKIV2L2	False	True	Major pathway of rRNA processing in the nucleolus and cytosol;mRNA Splicing - Major Pathway
23521	RPL13A	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
23524	SRRM2	False	True	mRNA Splicing - Major Pathway
23526	NA	False	True	Rho GTPase cycle;Neutrophil degranulation
23527	ACAP2	False	True	NA
23534	TNPO3	False	True	NA
23543	RBFOX2	False	True	FGFR2 alternative splicing
23566	LPAR3	False	True	G alpha (q) signalling events;G alpha (i) signalling events;Lysosphingolipid and LPA receptors
23576	NA	False	True	eNOS activation
23581	CASP14	True	True	Formation of the cornified envelope
23582	CCNDBP1	False	True	NA
23588	KLHDC2	False	True	NA
23589	CARHSP1	False	True	NA
23592	NA	False	True	Clearance of Nuclear Envelope Membranes from Chromatin;Initiation of Nuclear Envelope Reformation;Depolymerisation of the Nuclear Lamina
23597	NA	False	True	Mitochondrial Fatty Acid Beta-Oxidation
23603	CORO1C	False	True	NA
23607	CD2AP	False	True	Nephrin family interactions
23617	TSSK2	False	True	NA
23633	KPNA6	False	True	NA
23636	NUP62	False	True	ISG15 antiviral mechanism;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Rev-mediated nuclear export of HIV RNA;Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Viral Messenger RNA Synthesis;NEP/NS2 Interacts with the Cellular Export Machinery;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;snRNP Assembly;SUMOylation of DNA damage response and repair proteins;SUMOylation of ubiquitinylation proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;SUMOylation of SUMOylation proteins;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins;Transcriptional regulation by small RNAs;tRNA processing in the nucleus
23640	HSPBP1	False	True	NA
23641	LDOC1	False	True	NA
23644	EDC4	False	True	mRNA decay by 5' to 3' exoribonuclease
23647	ARFIP2	False	True	Retrograde transport at the Trans-Golgi-Network
23649	POLA2	False	True	Inhibition of replication initiation of damaged DNA by RB1/E2F1;Polymerase switching on the C-strand of the telomere;Telomere C-strand synthesis initiation;DNA replication initiation;Activation of the pre-replicative complex;Polymerase switching;Removal of the Flap Intermediate;Processive synthesis on the lagging strand
23673	STX12	False	True	NA
23677	SH3BP4	False	True	NA
23678	SGK3	False	True	Stimuli-sensing channels
23708	GSPT2	False	True	Eukaryotic Translation Termination;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
23731	NA	False	True	NA
23760	NA	False	True	PI and PC transport between ER and Golgi membranes
23770	FKBP8	False	True	Ub-specific processing proteases
23780	APOL2	False	True	NA
23787	MTCH1	False	True	NA
23788	MTCH2	False	True	NA
24144	TFIP11	False	True	mRNA Splicing - Major Pathway
24148	PRPF6	False	True	mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway
25747	Ppara	False	True	NA
25776	CBY1	False	True	Deactivation of the beta-catenin transactivating complex
25793	FBXO7	False	True	Neddylation;Antigen processing: Ubiquitination & Proteasome degradation
25801	GCA	False	True	Neutrophil degranulation
25813	SAMM50	False	True	Mitochondrial protein import;Cristae formation
25814	ATXN10	False	True	NA
25816	TNFAIP8	False	True	PI Metabolism
25820	ARIH1	False	True	ISG15 antiviral mechanism
25822	DNAJB5	False	True	NA
25824	PRDX5	False	True	Detoxification of Reactive Oxygen Species;TP53 Regulates Metabolic Genes
25827	FBXL2	False	True	NA
25831	HECTD1	False	True	Antigen processing: Ubiquitination & Proteasome degradation
25843	MOB4	False	True	NA
25864	ABHD14A	False	True	NA
25865	PRKD2	False	True	Sphingolipid de novo biosynthesis
25873	RPL36	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
25875	LETMD1	False	True	NA
25885	POLR1A	False	True	NoRC negatively regulates rRNA expression;B-WICH complex positively regulates rRNA expression;RNA Polymerase I Transcription Initiation;RNA Polymerase I Transcription Initiation;RNA Polymerase I Promoter Escape;RNA Polymerase I Chain Elongation;RNA Polymerase I Transcription Termination
25898	RCHY1	False	True	Translesion Synthesis by POLH;Antigen processing: Ubiquitination & Proteasome degradation
25900	IFFO1	False	True	NA
25909	AHCTF1	False	True	Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase
25913	POT1	False	True	Meiotic synapsis;Packaging Of Telomere Ends;DNA Damage/Telomere Stress Induced Senescence
25930	PTPN23	False	True	Interleukin-37 signaling
25936	NSL1	False	True	Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase
25937	WWTR1	False	True	Signaling by Hippo;YAP1- and WWTR1 (TAZ)-stimulated gene expression;YAP1- and WWTR1 (TAZ)-stimulated gene expression;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;Physiological factors;RUNX2 regulates osteoblast differentiation;RUNX3 regulates YAP1-mediated transcription
25943	NA	False	True	NA
25957	PNISR	False	True	NA
25972	NA	False	True	NA
25984	NA	True	False	Keratinization;Formation of the cornified envelope
25994	HIGD1A	False	True	Regulation of gene expression by Hypoxia-inducible Factor
25996	REXO2	False	True	NA
25998	IBTK	False	True	NA
26003	GORASP2	False	True	Golgi Cisternae Pericentriolar Stack Reorganization
26020	LRP10	False	True	Retinoid metabolism and transport
26030	NA	False	True	NA
26031	OSBPL3	False	True	Synthesis of bile acids and bile salts
26032	NA	False	True	NA
26037	SIPA1L1	False	True	Neurexins and neuroligins
26049	NA	False	True	NA
26052	DNM3	False	True	Toll Like Receptor 4 (TLR4) Cascade;Retrograde neurotrophin signalling;MHC class II antigen presentation;Recycling pathway of L1;Clathrin-mediated endocytosis
26054	SENP6	False	True	NA
26057	ANKRD17	False	True	NA
26058	GIGYF2	False	True	NA
26064	RAI14	False	True	NA
26073	POLDIP2	False	True	NA
26088	GGA1	False	True	TBC/RABGAPs;Amyloid fiber formation
26091	HERC4	False	True	Antigen processing: Ubiquitination & Proteasome degradation
26092	TOR1AIP1	False	True	NA
26097	CHTOP	False	True	Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA 3'-end processing
26098	EDRF1	False	True	NA
26099	SZRD1	False	True	NA
26112	CCDC69	False	True	NA
26121	PRPF31	False	True	mRNA Splicing - Major Pathway
26128	KIAA1279	False	True	NA
26130	GAPVD1	False	True	Clathrin-mediated endocytosis;RAB GEFs exchange GTP for GDP on RABs
26135	SERBP1	False	True	NA
26136	TES	False	True	NA
26137	NA	False	True	NA
26146	TRAF3IP1	False	True	Intraflagellar transport;Intraflagellar transport
26150	RIBC2	False	True	NA
26156	RSL1D1	False	True	NA
26164	MTG2	False	True	NA
26165	NA	False	True	NA
26168	SENP3	False	True	Major pathway of rRNA processing in the nucleolus and cytosol
26190	FBXW2	False	True	Association of TriC/CCT with target proteins during biosynthesis;Neddylation;Antigen processing: Ubiquitination & Proteasome degradation
26224	FBXL3	False	True	Association of TriC/CCT with target proteins during biosynthesis;Circadian Clock;Neddylation;Antigen processing: Ubiquitination & Proteasome degradation
26227	PHGDH	False	True	Serine biosynthesis
26258	BLOC1S6	False	True	Golgi Associated Vesicle Biogenesis
26260	FBXO25	False	True	NA
26261	FBXO24	False	True	NA
26267	FBXO10	False	True	Neddylation;Antigen processing: Ubiquitination & Proteasome degradation
26268	FBXO9	False	True	Neddylation;Antigen processing: Ubiquitination & Proteasome degradation
26270	FBXO6	False	True	Association of TriC/CCT with target proteins during biosynthesis;Neddylation;Antigen processing: Ubiquitination & Proteasome degradation
26271	FBXO5	False	True	SCF-beta-TrCP mediated degradation of Emi1;Regulation of APC/C activators between G1/S and early anaphase;Phosphorylation of Emi1;Activation of E2F1 target genes at G1/S;Mitotic Metaphase/Anaphase Transition
26272	FBXO4	False	True	Association of TriC/CCT with target proteins during biosynthesis;Neddylation;Antigen processing: Ubiquitination & Proteasome degradation
26273	FBXO3	False	True	NA
26275	HIBCH	False	True	Branched-chain amino acid catabolism
26278	SACS	False	True	NA
26285	NA	False	True	Tight junction interactions
26330	GAPDHS	False	True	Association of TriC/CCT with target proteins during biosynthesis;Glycolysis;Gluconeogenesis
26470	SEZ6L2	False	True	NA
26502	NARF	False	True	NA
26509	MYOF	False	True	NA
26517	TIMM13	False	True	Mitochondrial protein import
26524	LATS2	False	True	Signaling by Hippo
26528	DAZAP1	False	True	NA
26576	SRPK3	False	True	NA
26578	OSTF1	False	True	Neutrophil degranulation
26589	MRPL46	False	True	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation elongation;Mitochondrial translation termination
26750	RPS6KC1	False	True	NA
26973	CHORDC1	False	True	NA
26984	SEC22A	False	True	COPII-mediated vesicle transport
26985	AP3M1	False	True	Association of TriC/CCT with target proteins during biosynthesis
26986	PABPC1	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Deadenylation of mRNA;AUF1 (hnRNP D0) binds and destabilizes mRNA;Translation initiation complex formation;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
26993	AKAP8L	False	True	NA
26998	NA	False	True	NA
26999	CYFIP2	False	True	Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;VEGFA-VEGFR2 Pathway;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs
27000	DNAJC2	False	True	Regulation of HSF1-mediated heat shock response
27018	NGFRAP1	False	True	NADE modulates death signalling
27040	LAT	False	True	GPVI-mediated activation cascade;Generation of second messenger molecules;DAP12 signaling;Fc epsilon receptor (FCERI) signaling;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;FCERI mediated Ca+2 mobilization;RAF/MAP kinase cascade
27044	SND1	False	True	Signaling by BRAF and RAF fusions
27069	GHITM	False	True	NA
27072	VPS41	False	True	NA
27076	LYPD3	True	True	Post-translational modification: synthesis of GPI-anchored proteins
27095	TRAPPC3	False	True	COPII-mediated vesicle transport;RAB GEFs exchange GTP for GDP on RABs
27101	CACYBP	False	True	NA
27102	EIF2AK1	False	True	NA
27107	NA	False	True	NA
27109	NA	False	True	Formation of ATP by chemiosmotic coupling;Cristae formation
27113	BBC3	False	True	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members;Activation of PUMA and translocation to mitochondria;TP53 Regulates Transcription of Genes Involved in Cytochrome C Release;FOXO-mediated transcription of cell death genes
27128	CYTH4	False	True	Intra-Golgi traffic
27143	NA	False	True	NA
27153	NA	False	True	Generic Transcription Pathway
27229	TUBGCP4	False	True	Recruitment of mitotic centrosome proteins and complexes;Recruitment of NuMA to mitotic centrosomes
27230	SERP1	False	True	XBP1(S) activates chaperone genes
27236	ARFIP1	False	True	NA
27237	ARHGEF16	False	True	NRAGE signals death through JNK;Rho GTPase cycle;G alpha (12/13) signalling events
27238	GPKOW	False	True	mRNA Splicing - Major Pathway
27245	AHDC1	False	True	NA
27246	RNF115	False	True	Antigen processing: Ubiquitination & Proteasome degradation
27247	NFU1	False	True	NA
27248	ERLEC1	False	True	ABC-family proteins mediated transport;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Defective CFTR causes cystic fibrosis
27250	PDCD4	False	True	Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
27258	LSM3	False	True	mRNA decay by 5' to 3' exoribonuclease;mRNA decay by 5' to 3' exoribonuclease;mRNA Splicing - Major Pathway
27295	NA	False	True	NA
27316	RBMX	False	True	mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA
27330	RPS6KA6	False	True	Recycling pathway of L1;CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling;RSK activation;RSK activation
27332	ZNF638	False	True	Transcriptional regulation of white adipocyte differentiation
27335	EIF3K	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit
27339	PRPF19	False	True	Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;mRNA Splicing - Major Pathway
27347	STK39	False	True	NA
27430	MAT2B	False	True	Methylation;Ub-specific processing proteases
28916	NA	False	True	NA
28952	CCDC22	False	True	Neddylation
28954	REM1	False	True	NA
28957	MRPS28	False	True	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation elongation;Mitochondrial translation termination
28960	DCPS	False	True	mRNA decay by 3' to 5' exoribonuclease
28969	BZW2	False	True	NA
28970	C11orf54	False	True	NA
28972	NA	False	True	SRP-dependent cotranslational protein targeting to membrane;Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1);Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP);Synthesis, secretion, and deacylation of Ghrelin
28973	MRPS18B	False	True	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation elongation;Mitochondrial translation termination
28978	TMEM14A	False	True	NA
28982	NA	False	True	Iron uptake and transport
28985	MCTS1	False	True	NA
29058	NA	False	True	NA
29082	CHMP4A	False	True	Budding and maturation of HIV virion;Macroautophagy;Endosomal Sorting Complex Required For Transport (ESCRT)
29099	COMMD9	False	True	Neutrophil degranulation;Neddylation
29100	NA	False	True	NA
29104	N6AMT1	False	True	Methylation;Eukaryotic Translation Termination
29109	FHOD1	False	True	NA
29110	TBK1	False	True	IRF3 mediated activation of type 1 IFN;IRF3 mediated activation of type 1 IFN;Regulation of innate immune responses to cytosolic DNA;STAT6-mediated induction of chemokines;IRF3-mediated induction of type I IFN;Interleukin-37 signaling;TICAM1-dependent activation of IRF3/IRF7;TRAF3-dependent IRF activation pathway;TRAF6 mediated IRF7 activation;Negative regulators of DDX58/IFIH1 signaling;Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
29114	TAGLN3	False	True	NA
29115	SAP30BP	False	True	NoRC negatively regulates rRNA expression
29119	CTNNA3	False	True	NA
29127	RACGAP1	False	True	Rho GTPase cycle;MHC class II antigen presentation;COPI-dependent Golgi-to-ER retrograde traffic;Kinesins
29128	UHRF1	False	True	DNA methylation
29763	PACSIN3	False	True	Clathrin-mediated endocytosis
29766	TMOD3	False	True	Striated Muscle Contraction
29785	CYP2S1	False	True	Miscellaneous substrates;Xenobiotics;CYP2E1 reactions
29789	OLA1	False	True	Platelet degranulation
29843	SENP1	False	True	SUMO is proteolytically processed
29882	ANAPC2	False	True	Inactivation of APC/C via direct inhibition of the APC/C complex;APC/C:Cdc20 mediated degradation of Cyclin B;Autodegradation of Cdh1 by Cdh1:APC/C;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase;Regulation of APC/C activators between G1/S and early anaphase;APC/C:Cdc20 mediated degradation of mitotic proteins;Phosphorylation of the APC/C;APC-Cdc20 mediated degradation of Nek2A;Separation of Sister Chromatids;Senescence-Associated Secretory Phenotype (SASP);CDK-mediated phosphorylation and removal of Cdc6;Antigen processing: Ubiquitination & Proteasome degradation
29889	GNL2	False	True	NA
29894	CPSF1	False	True	Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA Derived from an Intronless Transcript;tRNA processing in the nucleus;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Processing of Intronless Pre-mRNAs
29896	TRA2A	False	True	NA
29926	GMPPA	False	True	Synthesis of GDP-mannose
29927	SEC61A1	False	True	ER-Phagosome pathway;SRP-dependent cotranslational protein targeting to membrane;XBP1(S) activates chaperone genes
29941	PKN3	False	True	RHO GTPases activate PKNs
29944	NA	False	True	NA
29950	SERTAD1	False	True	NA
29951	NA	False	True	NA
29968	PSAT1	False	True	Serine biosynthesis
29978	UBQLN2	False	True	Cargo recognition for clathrin-mediated endocytosis
29979	UBQLN1	False	True	Cargo recognition for clathrin-mediated endocytosis
29980	DONSON	False	True	NA
30000	TNPO2	False	True	NA
30011	SH3KBP1	False	True	EGFR downregulation;Negative regulation of MET activity;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Reelin signalling pathway;InlB-mediated entry of Listeria monocytogenes into host cell;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
30817	NA	False	True	Class B/2 (Secretin family receptors)
30827	CXXC1	False	True	XBP1(S) activates chaperone genes
30834	ZNRD1	False	True	NoRC negatively regulates rRNA expression;B-WICH complex positively regulates rRNA expression;RNA Polymerase I Transcription Initiation;RNA Polymerase I Transcription Initiation;RNA Polymerase I Promoter Escape;RNA Polymerase I Chain Elongation;RNA Polymerase I Transcription Termination
30849	NA	False	True	PI3K Cascade;Macroautophagy;Synthesis of PIPs at the Golgi membrane;Synthesis of PIPs at the early endosome membrane;Synthesis of PIPs at the late endosome membrane;Toll Like Receptor 9 (TLR9) Cascade;RHO GTPases Activate NADPH Oxidases
30850	CDR2L	False	True	NA
30851	TAX1BP3	False	True	RHO GTPases Activate Rhotekin and Rhophilins
30968	STOML2	False	True	Processing of SMDT1
33226	NA	False	True	NA
50488	MINK1	False	True	Oxidative Stress Induced Senescence
50489	CD207	False	True	Cross-presentation of soluble exogenous antigens (endosomes);Cross-presentation of soluble exogenous antigens (endosomes)
50515	NA	False	True	Chondroitin sulfate biosynthesis
50717	DCAF8	False	True	Neddylation
50809	HP1BP3	False	True	NA
50855	PARD6A	False	True	TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);Tight junction interactions;Asymmetric localization of PCP proteins
50856	NA	False	True	Dectin-2 family
50945	TBX22	False	True	NA
51002	TPRKB	False	True	tRNA modification in the nucleus and cytosol
51003	MED31	False	True	PPARA activates gene expression;Generic Transcription Pathway;Transcriptional regulation of white adipocyte differentiation;Transcriptional regulation of white adipocyte differentiation
51005	AMDHD2	False	True	Synthesis of UDP-N-acetyl-glucosamine
51008	ASCC1	False	True	ALKBH3 mediated reversal of alkylation damage
51009	DERL2	False	True	ABC-family proteins mediated transport;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Defective CFTR causes cystic fibrosis;ER Quality Control Compartment (ERQC)
51011	FAHD2A	False	True	NA
51015	ISOC1	False	True	NA
51019	CCDC53	False	True	NA
51026	GOLT1B	False	True	NA
51031	GLOD4	False	True	NA
51035	UBXN1	False	True	N-glycan trimming in the ER and Calnexin/Calreticulin cycle
51061	TXNDC11	False	True	NA
51068	NMD3	False	True	NA
51077	FCF1	False	True	rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol
51078	THAP4	False	True	NA
51086	TNNI3K	False	True	NA
51090	PLLP	False	True	NA
51100	SH3GLB1	False	True	NA
51110	LACTB2	False	True	NA
51119	SBDS	False	True	NA
51121	RPL26L1	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
51127	TRIM17	False	True	Interferon gamma signaling
51130	ASB3	False	True	Neddylation;Antigen processing: Ubiquitination & Proteasome degradation
51133	KCTD3	False	True	NA
51134	CEP83	False	True	Anchoring of the basal body to the plasma membrane
51141	INSIG2	False	True	Regulation of cholesterol biosynthesis by SREBP (SREBF)
51142	CHCHD2	False	True	Mitochondrial protein import
51148	CERCAM	False	True	NA
51150	SDF4	False	True	NA
51155	HN1	False	True	NA
51196	PLCE1	False	True	Synthesis of IP3 and IP4 in the cytosol
51200	CPA4	True	True	NA
51207	DUSP13	False	True	NA
51218	GLRX5	False	True	Mitochondrial iron-sulfur cluster biogenesis
51225	ABI3	False	True	NA
51248	PDZD11	False	True	Biotin transport and metabolism;Vitamin B5 (pantothenate) metabolism;Transport of vitamins, nucleosides, and related molecules;Ion influx/efflux at host-pathogen interface;Ion transport by P-type ATPases
51253	MRPL37	False	True	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation elongation;Mitochondrial translation termination
51255	RNF181	False	True	E3 ubiquitin ligases ubiquitinate target proteins
51267	CLEC1A	False	True	NA
51270	TFDP3	False	True	NA
51271	UBAP1	False	True	Budding and maturation of HIV virion;Membrane binding and targetting of GAG proteins;Endosomal Sorting Complex Required For Transport (ESCRT)
51295	ECSIT	False	True	MyD88:MAL(TIRAP) cascade initiated on plasma membrane;Complex I biogenesis;TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation;MyD88 cascade initiated on plasma membrane
51306	NA	False	True	Rho GTPase cycle
51307	FAM53C	False	True	NA
51317	PHF21A	False	True	HDACs deacetylate histones;Factors involved in megakaryocyte development and platelet production
51322	WAC	False	True	E3 ubiquitin ligases ubiquitinate target proteins
51324	SPG21	False	True	NA
51340	CRNKL1	False	True	mRNA Splicing - Major Pathway
51343	FZR1	False	True	Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase;Regulation of APC/C activators between G1/S and early anaphase;Phosphorylation of Emi1;Senescence-Associated Secretory Phenotype (SASP);CDK-mediated phosphorylation and removal of Cdc6;Cyclin A:Cdk2-associated events at S phase entry;Antigen processing: Ubiquitination & Proteasome degradation
51347	TAOK3	False	True	NA
51360	MBTPS2	False	True	Regulation of cholesterol biosynthesis by SREBP (SREBF);ATF6 (ATF6-alpha) activates chaperones;CREB3 factors activate genes;CREB3 factors activate genes;Assembly of active LPL and LIPC lipase complexes
51371	POMP	False	True	NA
51377	UCHL5	False	True	Downregulation of TGF-beta receptor signaling;UCH proteinases;UCH proteinases
51380	NA	False	True	Degradation of cysteine and homocysteine
51390	AIG1	False	True	NA
51399	TRAPPC4	False	True	COPII-mediated vesicle transport;Syndecan interactions;RAB GEFs exchange GTP for GDP on RABs
51400	PPME1	False	True	Cyclin A/B1/B2 associated events during G2/M transition
51421	AMOTL2	False	True	Signaling by Hippo
51434	ANAPC7	False	True	Inactivation of APC/C via direct inhibition of the APC/C complex;APC/C:Cdc20 mediated degradation of Cyclin B;Autodegradation of Cdh1 by Cdh1:APC/C;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase;Regulation of APC/C activators between G1/S and early anaphase;APC/C:Cdc20 mediated degradation of mitotic proteins;Phosphorylation of the APC/C;APC-Cdc20 mediated degradation of Nek2A;Separation of Sister Chromatids;Senescence-Associated Secretory Phenotype (SASP);CDK-mediated phosphorylation and removal of Cdc6;Antigen processing: Ubiquitination & Proteasome degradation
51435	SCARA3	False	True	NA
51455	REV1	False	True	Translesion synthesis by REV1;Translesion synthesis by POLK;Translesion synthesis by POLI;Termination of translesion DNA synthesis
51474	LIMA1	False	True	NA
51477	ISYNA1	False	True	Synthesis of IP2, IP, and Ins in the cytosol
51490	C9orf114	False	True	NA
51506	UFC1	False	True	NA
51512	GTSE1	False	True	G2/M Checkpoints;The role of GTSE1 in G2/M progression after G2 checkpoint
51514	DTL	False	True	Recognition of DNA damage by PCNA-containing replication complex;Neddylation
51517	NCKIPSD	False	True	Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs
51520	LARS	False	True	SeMet incorporation into proteins;Cytosolic tRNA aminoacylation
51522	TMEM14C	False	True	NA
51526	OSER1	False	True	NA
51530	ZC3HC1	False	True	NA
51531	C9orf156	False	True	NA
51535	PPHLN1	False	True	NA
51540	SCLY	False	True	Metabolism of ingested SeMet, Sec, MeSec into H2Se
51552	RAB14	False	True	Translocation of SLC2A4 (GLUT4) to the plasma membrane;Synthesis of PIPs at the plasma membrane;Neutrophil degranulation;RAB geranylgeranylation;RAB GEFs exchange GTP for GDP on RABs
51560	RAB6B	False	True	COPI-independent Golgi-to-ER retrograde traffic;Retrograde transport at the Trans-Golgi-Network;TBC/RABGAPs;RAB geranylgeranylation;RAB GEFs exchange GTP for GDP on RABs
51564	HDAC7	False	True	NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;SUMOylation of DNA damage response and repair proteins;Regulation of PTEN gene transcription
51569	UFM1	False	True	NA
51571	FAM49B	False	True	Platelet degranulation
51574	LARP7	False	True	NA
51588	PIAS4	False	True	Vitamin D (calciferol) metabolism;SUMOylation of DNA damage response and repair proteins;SUMOylation of transcription factors;SUMOylation of ubiquitinylation proteins;SUMOylation of transcription cofactors;SUMOylation of SUMOylation proteins;SUMOylation of intracellular receptors;SUMOylation of intracellular receptors;SUMOylation of DNA replication proteins;SUMOylation of immune response proteins;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Processing of DNA double-strand break ends;G2/M DNA damage checkpoint
51593	SRRT	False	True	RNA polymerase II transcribes snRNA genes;mRNA Splicing - Major Pathway
51594	NA	False	True	COPI-dependent Golgi-to-ER retrograde traffic
51596	CUTA	False	True	NA
51599	LSR	False	True	LDL clearance;VLDL clearance
51602	NOP58	False	True	SUMOylation of RNA binding proteins;rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol
51603	METTL13	False	True	NA
51606	ATP6V1H	False	True	ROS, RNS production in phagocytes;Nef Mediated CD4 Down-regulation;Nef Mediated CD8 Down-regulation;Insulin receptor recycling;Transferrin endocytosis and recycling;Ion channel transport
51611	DPH5	False	True	Synthesis of diphthamide-EEF2
51629	NA	False	True	NA
51631	LUC7L2	False	True	NA
51637	C14orf166	False	True	tRNA processing in the nucleus
51639	SF3B6	False	True	mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway
51649	MRPS23	False	True	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation elongation;Mitochondrial translation termination
51651	PTRH2	False	True	Ub-specific processing proteases
51659	GINS2	False	True	Unwinding of DNA;Unwinding of DNA
51661	FKBP7	False	True	NA
51663	ZFR	False	True	NA
51666	ASB4	False	True	Neddylation;Antigen processing: Ubiquitination & Proteasome degradation
51676	ASB2	False	True	Neddylation;Antigen processing: Ubiquitination & Proteasome degradation
51692	CPSF3	False	True	Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA Derived from an Intronless Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Processing of Intronless Pre-mRNAs
51714	NA	False	True	NA
51725	FBXO40	False	True	Neddylation;Antigen processing: Ubiquitination & Proteasome degradation
51726	DNAJB11	False	True	XBP1(S) activates chaperone genes
51735	RAPGEF6	False	True	NA
51741	WWOX	False	True	Nuclear signaling by ERBB4;Negative regulation of activity of TFAP2 (AP-2) family transcription factors;Activation of the TFAP2 (AP-2) family of transcription factors
51747	LUC7L3	False	True	NA
51752	ERAP1	False	True	Antigen Presentation: Folding, assembly and peptide loading of class I MHC
51759	C9orf78	False	True	NA
51763	INPP5K	False	True	Synthesis of PIPs at the plasma membrane
51776	ZAK	False	True	NA
51778	MYOZ2	False	True	NA
51780	KDM3B	False	True	HDMs demethylate histones
51806	NA	True	False	Neutrophil degranulation
53371	NUP54	False	True	ISG15 antiviral mechanism;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Rev-mediated nuclear export of HIV RNA;Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Viral Messenger RNA Synthesis;NEP/NS2 Interacts with the Cellular Export Machinery;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;snRNP Assembly;SUMOylation of DNA damage response and repair proteins;SUMOylation of ubiquitinylation proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;SUMOylation of SUMOylation proteins;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins;Transcriptional regulation by small RNAs;tRNA processing in the nucleus
53615	MBD3	False	True	HDACs deacetylate histones;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;Regulation of TP53 Activity through Acetylation;RNA Polymerase I Transcription Initiation;Regulation of PTEN gene transcription;Regulation of PTEN gene transcription
53635	PTOV1	False	True	NA
53826	FXYD6	False	True	Ion homeostasis;Ion transport by P-type ATPases
53838	C11orf24	False	True	NA
53918	PELO	False	True	NA
53938	PPIL3	False	True	mRNA Splicing - Major Pathway
53981	CPSF2	False	True	Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA Derived from an Intronless Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Processing of Intronless Pre-mRNAs
54065	SMIM11	False	True	NA
54107	POLE3	False	True	Recognition of DNA damage by PCNA-containing replication complex;Telomere C-strand synthesis initiation;PCNA-Dependent Long Patch Base Excision Repair;Termination of translesion DNA synthesis;HDR through Homologous Recombination (HRR);Gap-filling DNA repair synthesis and ligation in GG-NER;Dual Incision in GG-NER;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;DNA replication initiation;Activation of the pre-replicative complex
54187	NANS	False	True	Sialic acid metabolism
54205	CYCS	False	True	Release of apoptotic factors from the mitochondria;Formation of apoptosome;Activation of caspases through apoptosome-mediated cleavage;SMAC (DIABLO) binds to IAPs ;SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ;Transcriptional activation of mitochondrial biogenesis;Detoxification of Reactive Oxygen Species;TP53 Regulates Metabolic Genes;Respiratory electron transport;Regulation of the apoptosome activity;Regulation of the apoptosome activity
54206	ERRFI1	False	True	NA
54431	DNAJC10	False	True	NA
54432	YIPF1	False	True	NA
54433	GAR1	False	True	rRNA modification in the nucleus and cytosol
54439	RBM27	False	True	NA
54443	ANLN	False	True	NA
54458	PRR13	False	True	NA
54460	MRPS21	False	True	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation elongation;Mitochondrial translation termination
54461	FBXW5	False	True	Association of TriC/CCT with target proteins during biosynthesis;Neddylation;Antigen processing: Ubiquitination & Proteasome degradation
54468	MIOS	False	True	NA
54474	KRT20	False	True	Keratinization;Formation of the cornified envelope
54478	FAM64A	False	True	NA
54507	ADAMTSL4	False	True	Defective B3GALTL causes Peters-plus syndrome (PpS);O-glycosylation of TSR domain-containing proteins
54509	RHOF	False	True	Rho GTPase cycle;Neutrophil degranulation
54512	EXOSC4	False	True	ATF4 activates genes;mRNA decay by 3' to 5' exoribonuclease;Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA;Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA;KSRP (KHSRP) binds and destabilizes mRNA;Major pathway of rRNA processing in the nucleolus and cytosol
54517	PUS7	False	True	tRNA modification in the nucleus and cytosol
54535	CCHCR1	False	True	NA
54536	EXOC6	False	True	Translocation of SLC2A4 (GLUT4) to the plasma membrane;Insulin processing;VxPx cargo-targeting to cilium
54539	NDUFB11	False	True	Respiratory electron transport;Complex I biogenesis
54541	DDIT4	False	True	TP53 Regulates Metabolic Genes
54552	GNL3L	False	True	NA
54566	EPB41L4B	False	True	NA
54583	EGLN1	False	True	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
54585	LZTFL1	False	True	BBSome-mediated cargo-targeting to cilium
54617	INO80	False	True	UCH proteinases;DNA Damage Recognition in GG-NER
54623	PAF1	False	True	Formation of RNA Pol II elongation complex ;RNA Polymerase II Pre-transcription Events;RNA Polymerase II Transcription Elongation;E3 ubiquitin ligases ubiquitinate target proteins
54677	CROT	False	True	Beta-oxidation of pristanoyl-CoA;Peroxisomal protein import;Peroxisomal protein import
54708	MARCH5	False	True	NA
54737	MPHOSPH8	False	True	NA
54749	NA	False	True	NA
54751	FBLIM1	False	True	Cell-extracellular matrix interactions
54778	RNF111	False	True	Downregulation of SMAD2/3:SMAD4 transcriptional activity;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;Formation of Incision Complex in GG-NER;Antigen processing: Ubiquitination & Proteasome degradation
54780	NSMCE4A	False	True	SUMOylation of DNA damage response and repair proteins
54788	DNAJB12	False	True	NA
54814	QPCTL	False	True	NA
54826	NA	False	True	NA
54850	FBXL12	False	True	Neddylation;Antigen processing: Ubiquitination & Proteasome degradation
54852	PAQR5	False	True	NA
54859	ELP6	False	True	HATs acetylate histones
54867	NA	False	True	NA
54870	QRICH1	False	True	NA
54888	NSUN2	False	True	tRNA modification in the nucleus and cytosol;tRNA modification in the nucleus and cytosol
54901	CDKAL1	False	True	tRNA modification in the nucleus and cytosol
54903	MKS1	False	True	Hedgehog 'off' state;Anchoring of the basal body to the plasma membrane
54919	DNAAF5	False	True	NA
54936	ADPRHL2	False	True	POLB-Dependent Long Patch Base Excision Repair
54948	MRPL16	False	True	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation elongation;Mitochondrial translation termination
54955	C1orf109	False	True	NA
54962	TIPIN	False	True	Processing of DNA double-strand break ends
54971	BANP	False	True	Regulation of TP53 Activity through Association with Co-factors
54982	CLN6	False	True	NA
54987	C1orf123	False	True	NA
55002	TMCO3	False	True	NA
55008	HERC6	False	True	Antigen processing: Ubiquitination & Proteasome degradation
55010	PARPBP	False	True	NA
55011	PIH1D1	False	True	NA
55012	PPP2R3C	False	True	NA
55027	NA	False	True	NA
55030	FBXO34	False	True	NA
55048	VPS37C	False	True	Budding and maturation of HIV virion;Membrane binding and targetting of GAG proteins;Endosomal Sorting Complex Required For Transport (ESCRT)
55052	MRPL20	False	True	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation elongation;Mitochondrial translation termination
55066	NA	False	True	Regulation of pyruvate dehydrogenase (PDH) complex
55070	DET1	False	True	Antigen processing: Ubiquitination & Proteasome degradation
55075	UACA	False	True	Regulation of the apoptosome activity
55092	TMEM51	False	True	NA
55093	WDYHV1	False	True	NA
55094	GPATCH1	False	True	NA
55095	SAMD4B	False	True	NA
55100	WDR70	False	True	NA
55103	RALGPS2	False	True	NA
55108	BSDC1	False	True	NA
55114	ARHGAP17	False	True	Rho GTPase cycle
55119	NA	False	True	NA
55122	AKIRIN2	False	True	NA
55124	PIWIL2	False	True	PIWI-interacting RNA (piRNA) biogenesis
55125	CEP192	False	True	Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;AURKA Activation by TPX2
55127	HEATR1	False	True	rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol
55139	ANKZF1	False	True	NA
55143	CDCA8	False	True	Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;SUMOylation of DNA replication proteins;RHO GTPases Activate Formins;Mitotic Prometaphase
55149	MTPAP	False	True	NA
55153	NA	False	True	NA
55154	MSTO1	False	True	NA
55159	RFWD3	False	True	NA
55165	CEP55	False	True	NA
55167	MSL2	False	True	HATs acetylate histones
55177	RMDN3	False	True	NA
55179	NA	False	True	NA
55183	RIF1	False	True	Nonhomologous End-Joining (NHEJ)
55192	DNAJC17	False	True	NA
55197	RPRD1A	False	True	RNA polymerase II transcribes snRNA genes;RNA polymerase II transcribes snRNA genes
55210	ATAD3A	False	True	NA
55213	RCBTB1	False	True	NA
55223	TRIM62	False	True	Interferon gamma signaling
55229	PANK4	False	True	Coenzyme A biosynthesis
55231	CCDC87	False	True	NA
55236	UBA6	False	True	Synthesis of active ubiquitin: roles of E1 and E2 enzymes;Synthesis of active ubiquitin: roles of E1 and E2 enzymes;Antigen processing: Ubiquitination & Proteasome degradation
55238	SLC38A7	False	True	NA
55257	MRGBP	False	True	HATs acetylate histones
55272	IMP3	False	True	rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol
55276	PGM2	False	True	Glycogen synthesis;Neutrophil degranulation;Glycogen breakdown (glycogenolysis);Galactose catabolism;Pentose phosphate pathway
55281	TMEM140	False	True	NA
55290	BRF2	False	True	RNA Polymerase III Abortive And Retractive Initiation;RNA Polymerase III Transcription Initiation From Type 3 Promoter;RNA Polymerase III Transcription Initiation From Type 3 Promoter
55294	FBXW7	False	True	NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Association of TriC/CCT with target proteins during biosynthesis;Regulation of RUNX2 expression and activity;Neddylation;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation
55295	NA	False	True	NA
55324	ABCF3	False	True	NA
55326	NA	False	True	Synthesis of PA
55336	FBXL8	False	True	Neddylation;Antigen processing: Ubiquitination & Proteasome degradation
55351	NA	False	True	NA
55353	LAPTM4B	False	True	NA
55359	NA	False	True	NA
55379	LRRC59	False	True	NA
55388	MCM10	False	True	Activation of ATR in response to replication stress;Activation of the pre-replicative complex
55454	CSGALNACT2	False	True	Chondroitin sulfate biosynthesis
55466	DNAJA4	False	True	HSP90 chaperone cycle for steroid hormone receptors (SHR)
55505	NOP10	False	True	rRNA modification in the nucleus and cytosol
55510	DDX43	False	True	NA
55521	TRIM36	False	True	Antigen processing: Ubiquitination & Proteasome degradation
55561	CDC42BPG	False	True	NA
55568	NA	False	True	O-linked glycosylation of mucins
55585	UBE2Q1	False	True	Antigen processing: Ubiquitination & Proteasome degradation
55588	MED29	False	True	PPARA activates gene expression;Transcriptional regulation of white adipocyte differentiation;Transcriptional regulation of white adipocyte differentiation
55589	NA	False	True	NA
55602	CDKN2AIP	False	True	NA
55609	NA	False	True	NA
55611	OTUB1	False	True	Ub-specific processing proteases;Ovarian tumor domain proteases
55632	G2E3	False	True	NA
55644	OSGEP	False	True	tRNA modification in the nucleus and cytosol
55651	NHP2	False	True	Telomere Extension By Telomerase;rRNA modification in the nucleus and cytosol
55660	PRPF40A	False	True	mRNA Splicing - Major Pathway
55664	CDC37L1	False	True	Platelet degranulation
55665	URGCP	False	True	NA
55666	NPLOC4	False	True	Translesion Synthesis by POLH
55671	SMEK1	False	True	NA
55677	IWS1	False	True	Formation of RNA Pol II elongation complex ;RNA Polymerase II Pre-transcription Events;RNA Polymerase II Transcription Elongation
55679	LIMS2	False	True	Cell-extracellular matrix interactions
55681	SCYL2	False	True	NA
55699	IARS2	False	True	Mitochondrial tRNA aminoacylation
55706	NA	False	True	ISG15 antiviral mechanism;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Rev-mediated nuclear export of HIV RNA;Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Viral Messenger RNA Synthesis;NEP/NS2 Interacts with the Cellular Export Machinery;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;snRNP Assembly;SUMOylation of DNA damage response and repair proteins;SUMOylation of ubiquitinylation proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;SUMOylation of SUMOylation proteins;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins;Transcriptional regulation by small RNAs;tRNA processing in the nucleus
55707	NECAP2	False	True	Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis
55709	KBTBD4	False	True	NA
55714	NA	False	True	NA
55720	TSR1	False	True	Major pathway of rRNA processing in the nucleolus and cytosol
55722	CEP72	False	True	Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;AURKA Activation by TPX2
55737	VPS35	False	True	WNT ligand biogenesis and trafficking
55739	CARKD	False	True	Nicotinamide salvaging
55746	NUP133	False	True	ISG15 antiviral mechanism;Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Rev-mediated nuclear export of HIV RNA;Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Viral Messenger RNA Synthesis;NEP/NS2 Interacts with the Cellular Export Machinery;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;snRNP Assembly;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;SUMOylation of DNA damage response and repair proteins;SUMOylation of ubiquitinylation proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;SUMOylation of SUMOylation proteins;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins;Transcriptional regulation by small RNAs;RHO GTPases Activate Formins;tRNA processing in the nucleus;Mitotic Prometaphase
55748	CNDP2	False	True	Glutathione synthesis and recycling
55758	RCOR3	False	True	NA
55778	ZNF839	False	True	Generic Transcription Pathway
55787	TXLNG	False	True	NA
55791	LRIF1	False	True	NA
55812	SPATA7	False	True	NA
55814	BDP1	False	True	RNA Polymerase III Abortive And Retractive Initiation;RNA Polymerase III Transcription Initiation From Type 1 Promoter;RNA Polymerase III Transcription Initiation From Type 1 Promoter;RNA Polymerase III Transcription Initiation From Type 2 Promoter;RNA Polymerase III Transcription Initiation From Type 2 Promoter;RNA Polymerase III Transcription Initiation From Type 3 Promoter;RNA Polymerase III Transcription Initiation From Type 3 Promoter
55815	TSNAXIP1	False	True	NA
55835	CENPJ	False	True	Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain;AURKA Activation by TPX2
55845	BRK1	False	True	Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;VEGFA-VEGFR2 Pathway;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs
55846	ITFG2	False	True	NA
55848	PLGRKT	False	True	NA
55850	USE1	False	True	COPI-dependent Golgi-to-ER retrograde traffic
55861	DBNDD2	False	True	NA
55884	WSB2	False	True	Neddylation
55898	UNC45A	False	True	NA
55905	RNF114	False	True	Antigen processing: Ubiquitination & Proteasome degradation
55916	NXT2	False	True	NA
55929	DMAP1	False	True	HATs acetylate histones
55930	MYO5C	False	True	NA
55968	NSFL1C	False	True	NA
55970	GNG12	False	True	Activation of G protein gated Potassium channels;Glucagon signaling in metabolic regulation;G-protein activation;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;ADP signalling through P2Y purinoceptor 12;G beta:gamma signalling through PI3Kgamma;Prostacyclin signalling through prostacyclin receptor;Prostacyclin signalling through prostacyclin receptor;Adrenaline,noradrenaline inhibits insulin secretion;Adrenaline,noradrenaline inhibits insulin secretion;Ca2+ pathway;Ca2+ pathway;G alpha (q) signalling events;G alpha (12/13) signalling events;G beta:gamma signalling through PLC beta;G alpha (s) signalling events;ADP signalling through P2Y purinoceptor 1;ADP signalling through P2Y purinoceptor 1;G alpha (i) signalling events;G alpha (z) signalling events;Glucagon-type ligand receptors;Thromboxane signalling through TP receptor;Vasopressin regulates renal water homeostasis via Aquaporins;Thrombin signalling through proteinase activated receptors (PARs);Thrombin signalling through proteinase activated receptors (PARs);Presynaptic function of Kainate receptors;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding;G beta:gamma signalling through BTK;G beta:gamma signalling through CDC42;Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits
55975	KLHL7	False	True	NA
56061	UBFD1	False	True	NA
56063	TMEM234	False	True	NA
56243	KIAA1217	False	True	NA
56259	CTNNBL1	False	True	mRNA Splicing - Major Pathway
56288	PARD3	False	True	TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);Tight junction interactions
56300	NA	True	False	Interleukin-36 pathway
56311	NA	False	True	NA
56338	Txnip	False	True	NA
56339	METTL3	False	True	Processing of Capped Intron-Containing Pre-mRNA
56424	Stub1	False	True	NA
56475	RPRM	False	True	NA
56477	CCL28	False	True	Chemokine receptors bind chemokines;G alpha (i) signalling events
56647	BCCIP	False	True	NA
56648	EIF5A2	False	True	Hypusine synthesis from eIF5A-lysine
56649	TMPRSS4	False	True	NA
56650	CLDND1	False	True	NA
56658	TRIM39	False	True	Antigen processing: Ubiquitination & Proteasome degradation
56659	NA	False	True	Tandem pore domain halothane-inhibited K+ channel (THIK);Phase 4 - resting membrane potential
56667	NA	False	True	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC);Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS);Defective GALNT12 causes colorectal cancer 1 (CRCS1);Dectin-2 family;O-linked glycosylation of mucins;Termination of O-glycan biosynthesis
56850	GRIPAP1	False	True	NA
56882	CDC42SE1	False	True	NA
56888	KCMF1	False	True	Neutrophil degranulation
56893	UBQLN4	False	True	NA
56896	DPYSL5	False	True	CRMPs in Sema3A signaling
56902	PNO1	False	True	rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol
56904	SH3GLB2	False	True	NA
56907	NA	False	True	NA
56915	EXOSC5	False	True	ATF4 activates genes;mRNA decay by 3' to 5' exoribonuclease;Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA;Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA;KSRP (KHSRP) binds and destabilizes mRNA;Major pathway of rRNA processing in the nucleolus and cytosol
56924	PAK6	False	True	Activation of RAC1
56925	LXN	False	True	NA
56927	NA	False	True	NA
56931	DUS3L	False	True	NA
56935	SMCO4	False	True	NA
56954	NIT2	False	True	Neutrophil degranulation
56984	PSMG2	False	True	NA
56987	BBX	False	True	NA
56998	CTNNBIP1	False	True	Deactivation of the beta-catenin transactivating complex
57003	CCDC47	False	True	NA
57016	AKR1B10	False	True	Retinoid metabolism and transport
57062	DDX24	False	True	NA
57082	CASC5	False	True	Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Deposition of new CENPA-containing nucleosomes at the centromere;Mitotic Prometaphase
57085	AGTRAP	False	True	Signaling by BRAF and RAF fusions
57092	PCNP	False	True	NA
57093	TRIM49	False	True	NA
57107	PDSS2	False	True	Ubiquinol biosynthesis
57142	RTN4	False	True	Axonal growth inhibition (RHOA activation)
57157	NA	False	True	NA
57159	TRIM54	False	True	NA
57165	NA	False	True	Gap junction assembly
57168	NA	False	True	NA
57169	ZNFX1	False	True	NA
57172	CAMK1G	False	True	NA
57175	CORO1B	False	True	NA
57185	NIPAL3	False	True	Miscellaneous transport and binding events
57228	NA	False	True	NA
57402	S100A14	True	True	NA
57418	WDR18	False	True	Major pathway of rRNA processing in the nucleolus and cytosol
57462	KIAA1161	False	True	NA
57472	CNOT6	False	True	Deadenylation of mRNA;Activation of anterior HOX genes in hindbrain development during early embryogenesis;TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
57474	ZNF490	False	True	Generic Transcription Pathway
57479	PRR12	False	True	NA
57506	MAVS	False	True	DDX58/IFIH1-mediated induction of interferon-alpha/beta;Ovarian tumor domain proteases;TRAF3-dependent IRF activation pathway;TRAF6 mediated IRF7 activation;TRAF6 mediated NF-kB activation;TRAF6 mediated NF-kB activation;NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10;Negative regulators of DDX58/IFIH1 signaling;Negative regulators of DDX58/IFIH1 signaling
57507	NA	False	True	NA
57510	XPO5	False	True	MicroRNA (miRNA) biogenesis
57521	RPTOR	False	True	Macroautophagy;mTOR signalling;mTORC1-mediated signalling;HSF1-dependent transactivation;Energy dependent regulation of mTOR by LKB1-AMPK;TP53 Regulates Metabolic Genes;Regulation of PTEN gene transcription
57528	NA	False	True	NA
57530	CGN	False	True	TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
57542	KLHL42	False	True	Neddylation;Antigen processing: Ubiquitination & Proteasome degradation
57544	TXNDC16	False	True	NA
57552	NCEH1	False	True	LDL clearance
57553	NA	False	True	NA
57562	NA	False	True	NA
57563	KLHL8	False	True	NA
57565	KLHL14	False	True	NA
57584	NA	False	True	Rho GTPase cycle
57599	WDR48	False	True	Recognition of DNA damage by PCNA-containing replication complex;Ub-specific processing proteases;Fanconi Anemia Pathway
57600	FNIP2	False	True	NA
57617	VPS18	False	True	NA
57619	NA	False	True	NA
57623	NA	False	True	NA
57626	KLHL1	False	True	NA
57645	POGK	False	True	NA
57658	CALCOCO1	False	True	NA
57670	KIAA1549	False	True	Signaling by BRAF and RAF fusions
57680	CHD8	False	True	Deactivation of the beta-catenin transactivating complex
57707	TLDC1	False	True	NA
57718	PPP4R4	False	True	NA
57722	NA	False	True	NA
57794	SUGP1	False	True	mRNA Splicing - Major Pathway
57798	GATAD1	False	True	NA
57805	CCAR2	False	True	Regulation of HSF1-mediated heat shock response
57819	LSM2	False	True	mRNA decay by 5' to 3' exoribonuclease;mRNA decay by 5' to 3' exoribonuclease;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway
57820	CCNB1IP1	False	True	NA
58191	CXCL16	False	True	Chemokine receptors bind chemokines;G alpha (i) signalling events
58477	SRPRB	False	True	SRP-dependent cotranslational protein targeting to membrane;XBP1(S) activates chaperone genes
58484	NLRC4	False	True	TP53 Regulates Transcription of Caspase Activators and Caspases;The IPAF inflammasome;The IPAF inflammasome
58490	RPRD1B	False	True	RNA polymerase II transcribes snRNA genes;RNA polymerase II transcribes snRNA genes
58506	NA	False	True	NA
58515	SELK	False	True	NA
58517	RBM25	False	True	NA
58524	DMRT3	False	True	NA
58529	MYOZ1	False	True	NA
59277	NA	False	True	Non-integrin membrane-ECM interactions;Netrin-1 signaling
59286	UBL5	False	True	NA
59343	SENP2	False	True	SUMO is proteolytically processed
60312	AFAP1	False	True	NA
60314	C12orf10	False	True	NA
60485	SAV1	False	True	Signaling by Hippo
60491	NIF3L1	False	True	NA
60492	CCDC90B	False	True	NA
60496	AASDHPPT	False	True	Vitamin B5 (pantothenate) metabolism
60528	ELAC2	False	True	tRNA processing in the nucleus;tRNA processing in the mitochondrion;rRNA processing in the mitochondrion
60558	NA	False	True	NA
60684	TRAPPC11	False	True	RAB GEFs exchange GTP for GDP on RABs
63027	SLC22A23	False	True	NA
63892	THADA	False	True	tRNA modification in the nucleus and cytosol
63893	UBE2O	False	True	Antigen processing: Ubiquitination & Proteasome degradation
63925	ZNF335	False	True	Activation of anterior HOX genes in hindbrain development during early embryogenesis
63932	CXorf56	False	True	NA
63943	FKBPL	False	True	The role of GTSE1 in G2/M progression after G2 checkpoint
63951	DMRTA1	False	True	NA
63982	NA	False	True	Stimuli-sensing channels
64062	RBM26	False	True	NA
64065	NA	True	False	TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain;Formation of the cornified envelope
64087	MCCC2	False	True	Biotin transport and metabolism;Defective HLCS causes multiple carboxylase deficiency;Branched-chain amino acid catabolism
64092	SAMSN1	False	True	NA
64102	TNMD	False	True	NA
64105	CENPK	False	True	Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Deposition of new CENPA-containing nucleosomes at the centromere;Mitotic Prometaphase
64129	TINAGL1	False	True	NA
64184	EDDM3B	False	True	NA
64215	DNAJC1	False	True	NA
64320	RNF25	False	True	Antigen processing: Ubiquitination & Proteasome degradation
64326	RFWD2	False	True	Autodegradation of the E3 ubiquitin ligase COP1;Neddylation
64327	NA	False	True	NA
64344	HIF3A	False	True	Regulation of gene expression by Hypoxia-inducible Factor;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Transcriptional regulation of pluripotent stem cells;Neddylation
64374	SIL1	False	True	NA
64407	RGS18	False	True	G alpha (q) signalling events;G alpha (i) signalling events;G alpha (i) signalling events
64410	NA	False	True	Neddylation;Antigen processing: Ubiquitination & Proteasome degradation
64412	GZF1	False	True	NA
64417	C5orf28	False	True	NA
64423	NA	False	True	NA
64428	NARFL	False	True	Cytosolic iron-sulfur cluster assembly
64648	NA	False	True	NA
64663	NA	False	True	NA
64708	COPS7B	False	True	DNA Damage Recognition in GG-NER;Formation of TC-NER Pre-Incision Complex;Cargo recognition for clathrin-mediated endocytosis;Neddylation
64714	PDIA2	False	True	NA
64745	METTL17	False	True	NA
64750	SMURF2	False	True	Signaling by BMP;Downregulation of TGF-beta receptor signaling;Downregulation of TGF-beta receptor signaling;Downregulation of SMAD2/3:SMAD4 transcriptional activity;Downregulation of SMAD2/3:SMAD4 transcriptional activity;Asymmetric localization of PCP proteins;Degradation of AXIN;Hedgehog 'on' state;Hedgehog 'on' state;Ub-specific processing proteases;Regulation of RUNX3 expression and activity;Antigen processing: Ubiquitination & Proteasome degradation
64754	SMYD3	False	True	PKMTs methylate histone lysines
64755	C16orf58	False	True	NA
64759	TNS3	False	True	MET interacts with TNS proteins
64763	ZNF574	False	True	NA
64771	C6orf106	False	True	NA
64784	CRTC3	False	True	Transcriptional activation of mitochondrial biogenesis;Circadian Clock
64785	GINS3	False	True	Unwinding of DNA;Unwinding of DNA
64837	KLC2	False	True	MHC class II antigen presentation;RHO GTPases activate KTN1;COPI-dependent Golgi-to-ER retrograde traffic;Kinesins
64848	NA	False	True	NA
64849	NA	False	True	Sodium-coupled sulphate, di- and tri-carboxylate transporters
64866	CDCP1	False	True	NA
64926	NA	False	True	Regulation of RAS by GAPs;Signaling by RAS mutants
64965	MRPS9	False	True	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation elongation;Mitochondrial translation termination
64969	MRPS5	False	True	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation elongation;Mitochondrial translation termination
64976	MRPL40	False	True	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation elongation;Mitochondrial translation termination
64979	MRPL36	False	True	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation elongation;Mitochondrial translation termination
65018	PINK1	False	True	Pink/Parkin Mediated Mitophagy;FOXO-mediated transcription of cell death genes
65055	REEP1	False	True	Olfactory Signaling Pathway
65061	CDK15	False	True	NA
65095	KRI1	False	True	NA
65108	MARCKSL1	False	True	NA
65125	WNK1	False	True	Stimuli-sensing channels
65220	NADK	False	True	Nicotinate metabolism
65263	PYCRL	False	True	Amino acid synthesis and interconversion (transamination)
65265	C8orf33	False	True	NA
65266	WNK4	False	True	Stimuli-sensing channels
65268	WNK2	False	True	Stimuli-sensing channels
65977	NA	False	True	Synthesis of PIPs at the plasma membrane
65982	ZSCAN18	False	True	NA
71766	NA	False	True	NA
79001	VKORC1	False	True	Metabolism of vitamin K
79003	MIS12	False	True	Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase
79012	CAMKV	False	True	NA
79017	GGCT	True	True	Glutathione synthesis and recycling
79026	AHNAK	False	True	NA
79031	PDCL3	False	True	NA
79039	DDX54	False	True	NA
79047	KCTD15	False	True	Negative regulation of activity of TFAP2 (AP-2) family transcription factors
79050	NOC4L	False	True	rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol
79053	ALG8	False	True	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein;Defective ALG8 causes ALG8-CDG (CDG-1h)
79058	ASPSCR1	False	True	Translocation of SLC2A4 (GLUT4) to the plasma membrane
79073	TMEM109	False	True	NA
79109	MAPKAP1	False	True	PIP3 activates AKT signaling;CD28 dependent PI3K/Akt signaling;VEGFR2 mediated vascular permeability;Constitutive Signaling by AKT1 E17K in Cancer;Regulation of TP53 Degradation
79139	DERL1	False	True	ABC-family proteins mediated transport;N-glycan trimming in the ER and Calnexin/Calreticulin cycle;Defective CFTR causes cystic fibrosis;E3 ubiquitin ligases ubiquitinate target proteins
79152	NA	False	True	Sphingolipid de novo biosynthesis
79161	NA	False	True	NA
79171	RBM42	False	True	NA
79173	C19orf57	False	True	NA
79176	FBXL15	False	True	Neddylation;Antigen processing: Ubiquitination & Proteasome degradation
79177	ZNF576	False	True	NA
79180	EFHD2	False	True	NA
79183	NA	False	True	NA
79188	TMEM43	False	True	NA
79228	THOC6	False	True	Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA 3'-end processing
79366	NA	False	True	NA
79415	C17orf62	False	True	NA
79587	CARS2	False	True	Mitochondrial tRNA aminoacylation
79598	CEP97	False	True	Anchoring of the basal body to the plasma membrane
79622	SNRNP25	False	True	mRNA Splicing - Minor Pathway
79624	C6orf211	False	True	NA
79633	NA	False	True	NA
79647	NA	False	True	NA
79654	HECTD3	False	True	Antigen processing: Ubiquitination & Proteasome degradation
79657	RPAP3	False	True	NA
79666	PLEKHF2	False	True	NA
79669	C3orf52	False	True	NA
79691	QTRTD1	False	True	tRNA modification in the nucleus and cytosol
79696	ZC2HC1C	False	True	NA
79710	MORC4	False	True	NA
79711	IPO4	False	True	NA
79717	PPCS	False	True	Coenzyme A biosynthesis
79718	TBL1XR1	False	True	RORA activates gene expression;BMAL1:CLOCK,NPAS2 activates circadian gene expression;PPARA activates gene expression;PPARA activates gene expression;NOTCH1 Intracellular Domain Regulates Transcription;Transcriptional activation of mitochondrial biogenesis;Activation of gene expression by SREBF (SREBP);Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;HDACs deacetylate histones;Transcriptional regulation of white adipocyte differentiation;Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha);Circadian Clock;Loss of MECP2 binding ability to the NCoR/SMRT complex;Regulation of MECP2 expression and activity
79724	NA	False	True	NA
79726	WDR59	False	True	NA
79728	PALB2	False	True	HDR through Homologous Recombination (HRR);Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA);Resolution of D-loop Structures through Holliday Junction Intermediates;Homologous DNA Pairing and Strand Exchange
79763	ISOC2	False	True	NA
79770	TXNDC15	False	True	NA
79786	KLHL36	False	True	NA
79798	NA	False	True	NA
79801	SHCBP1	False	True	NA
79809	NA	False	True	Hedgehog 'off' state;Intraflagellar transport
79811	SLTM	False	True	NA
79822	NA	False	True	NA
79830	NA	False	True	NA
79831	KDM8	False	True	HDMs demethylate histones
79839	CCDC102B	False	True	NA
79853	TM4SF20	False	True	NA
79858	NEK11	False	True	NA
79861	TUBAL3	False	True	Translocation of SLC2A4 (GLUT4) to the plasma membrane;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;Gap junction assembly;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HSP90 chaperone cycle for steroid hormone receptors (SHR);Recruitment of NuMA to mitotic centrosomes;Formation of tubulin folding intermediates by CCT/TriC;Post-chaperonin tubulin folding pathway;Recycling pathway of L1;Recycling pathway of L1;Cilium Assembly;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;Carboxyterminal post-translational modifications of tubulin;Carboxyterminal post-translational modifications of tubulin;Activation of AMPK downstream of NMDARs;Kinesins
79869	CPSF7	False	True	Cleavage of Growing Transcript in the Termination Region ;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Processing of Intronless Pre-mRNAs
79873	NUDT18	False	True	Phosphate bond hydrolysis by NUDT proteins
79887	PLBD1	True	True	Acyl chain remodelling of PC;Acyl chain remodelling of PE;Acyl chain remodelling of PI;Hydrolysis of LPC
79901	CYBRD1	False	True	Iron uptake and transport
79930	DOK3	False	True	Neutrophil degranulation
79932	NA	False	True	NA
79947	DHDDS	False	True	Synthesis of Dolichyl-phosphate;Defective DHDDS causes retinitis pigmentosa 59
79968	WDR76	False	True	NA
79980	DSN1	False	True	Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Neutrophil degranulation;Mitotic Prometaphase
79983	POF1B	True	True	NA
80007	C10orf88	False	True	NA
80011	FAM192A	False	True	NA
80012	PHC3	False	True	Oxidative Stress Induced Senescence;SUMOylation of DNA damage response and repair proteins;SUMOylation of transcription cofactors;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA methylation proteins;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known;Regulation of PTEN gene transcription;Regulation of PTEN gene transcription;Transcriptional Regulation by E2F6
80017	C14orf159	False	True	NA
80028	FBXL18	False	True	NA
80086	TUBA4B	False	True	NA
80139	NA	False	True	Generic Transcription Pathway
80145	THOC7	False	True	Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA 3'-end processing
80153	EDC3	False	True	mRNA decay by 5' to 3' exoribonuclease
80154	GOLGA2P10	False	True	NA
80176	SPSB1	False	True	Neddylation;Antigen processing: Ubiquitination & Proteasome degradation
80179	MYO19	False	True	NA
80185	TTI2	False	True	NA
80196	RNF34	False	True	Regulation of TP53 Degradation;Antigen processing: Ubiquitination & Proteasome degradation
80207	OPA3	False	True	NA
80216	ALPK1	False	True	NA
80217	NA	False	True	NA
80218	NAA50	False	True	NA
80223	RAB11FIP1	False	True	NA
80273	GRPEL1	False	True	Mitochondrial protein import
80279	CDK5RAP3	False	True	NA
80301	PLEKHO2	False	True	Neutrophil degranulation
80311	KLHL15	False	True	NA
80314	EPC1	False	True	HATs acetylate histones;Transcriptional Regulation by E2F6
80318	GKAP1	False	True	NA
80332	ADAM33	False	True	NA
80349	WDR61	False	True	Formation of RNA Pol II elongation complex ;mRNA decay by 3' to 5' exoribonuclease;RNA Polymerase II Pre-transcription Events;RNA Polymerase II Transcription Elongation;E3 ubiquitin ligases ubiquitinate target proteins
80705	TSGA10	False	True	NA
80726	KIAA1683	False	True	NA
80742	PRR3	False	True	NA
80775	TMEM177	False	True	NA
80777	CYB5B	False	True	Phase I - Functionalization of compounds
80817	CEP44	False	True	NA
80856	KIAA1715	False	True	NA
81027	TUBB1	False	True	Translocation of SLC2A4 (GLUT4) to the plasma membrane;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;Gap junction assembly;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HSP90 chaperone cycle for steroid hormone receptors (SHR);Recruitment of NuMA to mitotic centrosomes;Prefoldin mediated transfer of substrate  to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Post-chaperonin tubulin folding pathway;Recycling pathway of L1;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;Carboxyterminal post-translational modifications of tubulin;Carboxyterminal post-translational modifications of tubulin;Activation of AMPK downstream of NMDARs;Kinesins
81494	CFHR5	False	True	Regulation of Complement cascade
81544	GDPD5	False	True	Glycerophospholipid catabolism
81545	FBXO38	False	True	NA
81556	VWA9	False	True	RNA polymerase II transcribes snRNA genes;RNA polymerase II transcribes snRNA genes
81565	NDEL1	False	True	Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase
81567	TXNDC5	False	True	Lysosome Vesicle Biogenesis;Golgi Associated Vesicle Biogenesis;Neutrophil degranulation
81572	PDRG1	False	True	NA
81576	CCDC130	False	True	NA
81605	URM1	False	True	tRNA modification in the nucleus and cytosol
81611	ANP32E	False	True	NA
81624	DIAPH3	False	True	RHO GTPases Activate Formins
81629	TSSK3	False	True	NA
81671	NA	False	True	NA
81786	TRIM7	False	True	NA
81788	NUAK2	False	True	NA
81790	RNF170	False	True	NA
81810	NA	False	True	NA
81844	TRIM56	False	True	Regulation of innate immune responses to cytosolic DNA
81853	TMEM14B	False	True	NA
81873	ARPC5L	False	True	NA
81875	NA	False	True	Major pathway of rRNA processing in the nucleolus and cytosol
81889	FAHD1	False	True	Citric acid cycle (TCA cycle)
81929	SEH1L	False	True	ISG15 antiviral mechanism;Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Rev-mediated nuclear export of HIV RNA;Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Viral Messenger RNA Synthesis;NEP/NS2 Interacts with the Cellular Export Machinery;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;snRNP Assembly;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;SUMOylation of DNA damage response and repair proteins;SUMOylation of ubiquitinylation proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;SUMOylation of SUMOylation proteins;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins;Transcriptional regulation by small RNAs;RHO GTPases Activate Formins;tRNA processing in the nucleus;Mitotic Prometaphase
83446	CCDC70	False	True	NA
83481	EPPK1	True	True	NA
83540	NUF2	False	True	Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase
83541	FAM110A	False	True	NA
83594	NUDT12	False	True	Nicotinamide salvaging
83640	FAM103A1	False	True	NA
83659	NA	False	True	NA
83660	TLN2	False	True	NA
83692	CD99L2	False	True	Cell surface interactions at the vascular wall
83693	NA	False	True	NA
83694	NA	False	True	NA
83699	SH3BGRL2	False	True	NA
83719	YPEL3	False	True	NA
83737	ITCH	False	True	Downregulation of ERBB4 signaling;NOD1/2 Signaling Pathway;Activated NOTCH1 Transmits Signal to the Nucleus;Activated NOTCH1 Transmits Signal to the Nucleus;Degradation of GLI1 by the proteasome;Hedgehog 'on' state;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Negative regulators of DDX58/IFIH1 signaling;Antigen processing: Ubiquitination & Proteasome degradation
83742	NA	False	True	NA
83861	RSPH3	False	True	NA
83871	RAB34	False	True	RAB geranylgeranylation
83878	USHBP1	False	True	NA
83939	EIF2A	False	True	NA
83942	TSSK1B	False	True	NA
83983	TSSK6	False	True	NA
83990	BRIP1	False	True	Cytosolic iron-sulfur cluster assembly;HDR through Single Strand Annealing (SSA);HDR through Homologous Recombination (HRR);Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA);Resolution of D-loop Structures through Holliday Junction Intermediates;Homologous DNA Pairing and Strand Exchange;Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;Regulation of TP53 Activity through Phosphorylation;G2/M DNA damage checkpoint
84059	NA	False	True	NA
84060	RBM48	False	True	NA
84063	KIRREL2	False	True	Nephrin family interactions
84065	NA	False	True	NA
84074	NA	False	True	NA
84076	TKTL2	False	True	NA
84078	KBTBD7	False	True	Regulation of RAS by GAPs;Neddylation;Antigen processing: Ubiquitination & Proteasome degradation
84080	ENKD1	False	True	NA
84102	SLC41A2	False	True	Metal ion SLC transporters
84108	PCGF6	False	True	Transcriptional Regulation by E2F6
84128	NA	False	True	rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol
84131	CEP78	False	True	Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;AURKA Activation by TPX2
84133	ZNRF3	False	True	Regulation of FZD by ubiquitination
84134	TOMM40L	False	True	NA
84140	FAM161A	False	True	NA
84148	KAT8	False	True	HATs acetylate histones
84154	RPF2	False	True	NA
84163	NA	False	True	NA
84164	ASCC2	False	True	ALKBH3 mediated reversal of alkylation damage
84168	ANTXR1	False	True	Uptake and function of anthrax toxins
84174	SLA2	False	True	NA
84218	NA	False	True	NA
84219	WDR24	False	True	NA
84254	CAMKK1	False	True	CaMK IV-mediated phosphorylation of CREB;CaMK IV-mediated phosphorylation of CREB;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;Activation of RAC1 downstream of NMDARs;Activation of RAC1 downstream of NMDARs
84259	DCUN1D5	False	True	Neddylation
84260	TCHP	False	True	NA
84262	PSMG3	False	True	NA
84273	NA	False	True	NA
84277	DNAJC30	False	True	NA
84290	CAPNS2	False	True	Degradation of the extracellular matrix;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
84292	WDR83	False	True	MAP2K and MAPK activation
84294	UTP23	False	True	NA
84300	UQCC2	False	True	NA
84301	DDI2	False	True	NA
84314	TMEM107	False	True	NA
84320	ACBD6	False	True	Mitochondrial Fatty Acid Beta-Oxidation
84324	SARNP	False	True	Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA 3'-end processing
84333	PCGF5	False	True	RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
84445	LZTS2	False	True	NA
84447	SYVN1	False	True	XBP1(S) activates chaperone genes;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;ER Quality Control Compartment (ERQC)
84457	PHYHIPL	False	True	NA
84501	NA	False	True	NA
84522	JAGN1	False	True	NA
84525	HOPX	False	True	NA
84614	NA	False	True	NA
84617	TUBB6	False	True	Translocation of SLC2A4 (GLUT4) to the plasma membrane;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;Gap junction assembly;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HSP90 chaperone cycle for steroid hormone receptors (SHR);Recruitment of NuMA to mitotic centrosomes;Prefoldin mediated transfer of substrate  to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Post-chaperonin tubulin folding pathway;Recycling pathway of L1;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;Carboxyterminal post-translational modifications of tubulin;Carboxyterminal post-translational modifications of tubulin;Activation of AMPK downstream of NMDARs;Kinesins
84619	ZGPAT	False	True	NA
84687	PPP1R9B	False	True	NA
84707	BEX2	False	True	NA
84708	LNX1	False	True	Antigen processing: Ubiquitination & Proteasome degradation
84717	HDGFRP2	False	True	NA
84759	PCGF1	False	True	NA
84790	TUBA1C	False	True	Translocation of SLC2A4 (GLUT4) to the plasma membrane;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;Gap junction assembly;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HSP90 chaperone cycle for steroid hormone receptors (SHR);Recruitment of NuMA to mitotic centrosomes;Prefoldin mediated transfer of substrate  to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Post-chaperonin tubulin folding pathway;Recycling pathway of L1;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;Carboxyterminal post-translational modifications of tubulin;Carboxyterminal post-translational modifications of tubulin;Activation of AMPK downstream of NMDARs;Kinesins
84808	NA	False	True	Transcriptional activation of mitochondrial biogenesis
84823	LMNB2	False	True	NA
84832	ANKRD36BP1	False	True	NA
84833	NA	False	True	NA
84861	KLHL22	False	True	Neddylation;Antigen processing: Ubiquitination & Proteasome degradation
84873	GPR128	False	True	NA
84886	NA	False	True	NA
84893	FBXO18	False	True	NA
84902	CEP89	False	True	Anchoring of the basal body to the plasma membrane
84912	SLC35B4	False	True	Transport of nucleotide sugars
84926	NA	False	True	NA
84930	MASTL	False	True	MASTL Facilitates Mitotic Progression;MASTL Facilitates Mitotic Progression
84936	ZFYVE19	False	True	NA
84939	MUM1	False	True	NA
84946	LTV1	False	True	Major pathway of rRNA processing in the nucleolus and cytosol
84951	TNS4	False	True	MET interacts with TNS proteins
84952	CGNL1	False	True	NA
84962	AJUBA	False	True	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Regulation of PLK1 Activity at G2/M Transition;Activation of anterior HOX genes in hindbrain development during early embryogenesis
84966	NA	False	True	NA
84975	MFSD5	False	True	NA
84987	COX14	False	True	TP53 Regulates Metabolic Genes;Respiratory electron transport
84993	UBL7	False	True	NA
84996	URB1-AS1	False	True	NA
85013	TMEM128	False	True	NA
85025	NA	False	True	NA
85302	FBF1	False	True	Anchoring of the basal body to the plasma membrane
85359	DGCR6L	False	True	NA
85366	MYLK2	False	True	NA
85369	STRIP1	False	True	NA
85395	NA	False	True	NA
85415	RHPN2	False	True	RHO GTPases Activate Rhotekin and Rhophilins;RHO GTPases Activate Rhotekin and Rhophilins
85437	ZCRB1	False	True	mRNA Splicing - Minor Pathway
85439	STON2	False	True	Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis
85440	DOCK7	False	True	MET activates RAP1 and RAC1;Factors involved in megakaryocyte development and platelet production
85451	UNK	False	True	NA
85458	DIXDC1	False	True	NA
85459	CEP295	False	True	NA
85464	SSH2	False	True	NA
85481	PSKH2	False	True	NA
87178	PNPT1	False	True	NA
89122	TRIM4	False	True	Antigen processing: Ubiquitination & Proteasome degradation
89777	NA	True	False	Neutrophil degranulation
89857	KLHL6	False	True	NA
89872	NA	False	True	Passive transport by Aquaporins
89885	FATE1	False	True	NA
89941	RHOT2	False	True	Rho GTPase cycle
89953	KLC4	False	True	MHC class II antigen presentation;RHO GTPases activate KTN1;COPI-dependent Golgi-to-ER retrograde traffic;Kinesins
90060	CCDC120	False	True	NA
90161	NA	False	True	HS-GAG biosynthesis
90293	KLHL13	False	True	Neddylation;Antigen processing: Ubiquitination & Proteasome degradation
90379	DCAF15	False	True	NA
90407	TMEM41A	False	True	NA
90410	IFT20	False	True	Intraflagellar transport;Intraflagellar transport
90411	MCFD2	False	True	COPII-mediated vesicle transport;Cargo concentration in the ER;Transport to the Golgi and subsequent modification
90416	NA	False	True	NA
90417	KNSTRN	False	True	NA
90488	NA	False	True	NA
90523	MLIP	False	True	NA
90594	ZNF439	False	True	Generic Transcription Pathway
90678	LRSAM1	False	True	Antigen processing: Ubiquitination & Proteasome degradation
90799	CEP95	False	True	NA
90861	HN1L	False	True	NA
90864	NA	False	True	Neddylation
90871	TMEM261	False	True	NA
90933	TRIM41	False	True	Antigen processing: Ubiquitination & Proteasome degradation
90957	DHX57	False	True	NA
91147	TMEM67	False	True	Anchoring of the basal body to the plasma membrane
91272	BOD1	False	True	NA
91319	DERL3	False	True	ABC-family proteins mediated transport;Defective CFTR causes cystic fibrosis
91369	ANKRD40	False	True	NA
91464	NA	False	True	NA
91607	NA	False	True	NA
91612	CHURC1	False	True	NA
91624	NEXN	False	True	NA
91647	ATPAF2	False	True	NA
91662	NLRP12	False	True	NA
91663	MYADM	False	True	NA
91683	SYT12	False	True	Neurexins and neuroligins
91694	LONRF1	False	True	Antigen processing: Ubiquitination & Proteasome degradation
91748	ELMSAN1	False	True	NA
91754	NEK9	False	True	Activation of NIMA Kinases NEK9, NEK6, NEK7;Nuclear Pore Complex (NPC) Disassembly
91768	NA	False	True	Cyclin E associated events during G1/S transition ;Cyclin A:Cdk2-associated events at S phase entry;Factors involved in megakaryocyte development and platelet production
91807	MYLK3	False	True	NA
91833	WDR20	False	True	Ub-specific processing proteases
91869	RFT1	False	True	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein;Defective RFT1 causes RFT1-CDG (CDG-1n)
92070	NA	False	True	NA
92092	ZC3HAV1L	False	True	NA
92140	MTDH	False	True	NA
92345	NAF1	False	True	NA
92346	C1orf105	False	True	NA
92359	CRB3	False	True	Tight junction interactions
92399	MRRF	False	True	Mitochondrial translation termination
92483	LDHAL6B	False	True	Pyruvate metabolism
92521	SPECC1	False	True	NA
92558	NA	False	True	NA
92597	MOB1B	False	True	Signaling by Hippo
92749	NA	False	True	NA
92840	REEP6	False	True	Olfactory Signaling Pathway
92906	HNRNPLL	False	True	NA
92922	NA	False	True	NA
92935	MARS2	False	True	Mitochondrial tRNA aminoacylation
92979	MARCH9	False	True	NA
93100	NAPRT	False	True	Nicotinamide salvaging;Neutrophil degranulation
93323	HAUS8	False	True	Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;AURKA Activation by TPX2
93426	SYCE1	False	True	Meiotic synapsis
93986	FOXP2	False	True	NA
94005	PIGS	False	True	Attachment of GPI anchor to uPAR
94081	SFXN1	False	True	NA
94101	ORMDL1	False	True	Sphingolipid de novo biosynthesis
94103	ORMDL3	False	True	Sphingolipid de novo biosynthesis;Neutrophil degranulation
94107	NA	False	True	NA
96459	FNIP1	False	True	NA
103910	MYL12B	False	True	EPHA-mediated growth cone collapse;Sema4D induced cell migration and growth-cone collapse;Smooth Muscle Contraction;RHO GTPases activate PKNs;RHO GTPases activate CIT;RHO GTPases Activate ROCKs;RHO GTPases activate PAKs;RHO GTPases activate PAKs
112399	EGLN3	False	True	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
112616	NA	False	True	NA
112714	TUBA3E	False	True	Translocation of SLC2A4 (GLUT4) to the plasma membrane;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;Gap junction assembly;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HSP90 chaperone cycle for steroid hormone receptors (SHR);Recruitment of NuMA to mitotic centrosomes;Formation of tubulin folding intermediates by CCT/TriC;Post-chaperonin tubulin folding pathway;Recycling pathway of L1;Recycling pathway of L1;Cilium Assembly;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;Carboxyterminal post-translational modifications of tubulin;Carboxyterminal post-translational modifications of tubulin;Activation of AMPK downstream of NMDARs;Kinesins
112770	C1orf85	False	True	NA
112802	KRT71	False	True	Keratinization;Formation of the cornified envelope
112858	TP53RK	False	True	tRNA modification in the nucleus and cytosol;Regulation of TP53 Activity through Phosphorylation
112869	CCDC101	False	True	HATs acetylate histones
112936	VPS26B	False	True	NA
112950	MED8	False	True	PPARA activates gene expression;Generic Transcription Pathway;Transcriptional regulation of white adipocyte differentiation;Transcriptional regulation of white adipocyte differentiation
113146	AHNAK2	False	True	NA
113220	KIF12	False	True	COPI-dependent Golgi-to-ER retrograde traffic;Kinesins
113452	TMEM54	False	True	NA
113829	NA	False	True	NA
113878	DTX2	False	True	Activated NOTCH1 Transmits Signal to the Nucleus;Activated NOTCH1 Transmits Signal to the Nucleus
114792	KLHL32	False	True	NA
114818	KLHL29	False	True	NA
114822	RHPN1	False	True	RHO GTPases Activate Rhotekin and Rhophilins;RHO GTPases Activate Rhotekin and Rhophilins
114824	PNMA5	False	True	NA
114882	NA	False	True	Acyl chain remodelling of PS
114883	OSBPL9	False	True	Synthesis of bile acids and bile salts
114897	NA	False	True	NA
114907	FBXO32	False	True	Neddylation;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes;Antigen processing: Ubiquitination & Proteasome degradation
114971	PTPMT1	False	True	Synthesis of PG
114984	FLYWCH2	False	True	NA
115106	HAUS1	False	True	Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;AURKA Activation by TPX2
115207	KCTD12	False	True	NA
115290	FBXO17	False	True	Neddylation;Antigen processing: Ubiquitination & Proteasome degradation
115353	LRRC42	False	True	NA
115548	FCHO2	False	True	Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis
116039	NA	False	True	NA
116138	KLHDC3	False	True	XBP1(S) activates chaperone genes
116173	CMTM5	False	True	NA
116540	MRPL53	False	True	Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation elongation;Mitochondrial translation termination
116988	NA	False	True	NA
117157	SH2D1B	False	True	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
117159	DCD	True	True	Antimicrobial peptides
117177	RAB3IP	False	True	Anchoring of the basal body to the plasma membrane;VxPx cargo-targeting to cilium;BBSome-mediated cargo-targeting to cilium;RAB GEFs exchange GTP for GDP on RABs
117178	SSX2IP	False	True	NA
117284	Lrrc7	False	True	NA
117583	PARD3B	False	True	NA
118460	EXOSC6	False	True	ATF4 activates genes;mRNA decay by 3' to 5' exoribonuclease;Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA;Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA;KSRP (KHSRP) binds and destabilizes mRNA;Major pathway of rRNA processing in the nucleolus and cytosol
119016	NA	False	True	NA
119358	NA	False	True	NA
120892	LRRK2	False	True	PTK6 promotes HIF1A stabilization
121355	GTSF1	False	True	NA
121457	IKBIP	False	True	NA
122060	SLAIN1	False	True	NA
122258	NA	False	True	NA
123169	LEO1	False	True	Formation of RNA Pol II elongation complex ;Formation of the beta-catenin:TCF transactivating complex;RNA Polymerase II Pre-transcription Events;RNA Polymerase II Transcription Elongation;E3 ubiquitin ligases ubiquitinate target proteins
123811	NA	False	True	NA
123920	CMTM3	False	True	NA
124220	ZG16B	True	True	NA
124540	MSI2	False	True	NA
124641	OVCA2	False	True	NA
124801	LSM12	False	True	NA
124997	WDR81	False	True	NA
125058	TBC1D16	False	True	TBC/RABGAPs
125115	KRT40	False	True	Keratinization;Formation of the cornified envelope
125488	NA	False	True	NA
125875	NA	False	True	NA
126003	TRAPPC5	False	True	COPII-mediated vesicle transport;RAB GEFs exchange GTP for GDP on RABs
126070	ZNF440	False	True	Generic Transcription Pathway
126123	NA	False	True	Sperm:Oocyte Membrane Binding
126298	NA	False	True	NA
126326	NA	False	True	NA
126353	MISP	False	True	NA
126433	FBXO27	False	True	Neddylation;Antigen processing: Ubiquitination & Proteasome degradation
127247	ASB17	False	True	Neddylation;Antigen processing: Ubiquitination & Proteasome degradation
127544	RNF19B	False	True	Antigen processing: Ubiquitination & Proteasome degradation
127703	C1orf216	False	True	NA
128240	APOA1BP	False	True	Nicotinamide salvaging
128653	NA	False	True	NA
128869	PIGU	False	True	Attachment of GPI anchor to uPAR
128989	TANGO2	False	True	NA
129807	NEU4	False	True	Glycosphingolipid metabolism;Sialic acid metabolism
129852	NA	False	True	NA
130399	NA	False	True	Signaling by NODAL;Regulation of signaling by NODAL;Signaling by Activin;Signaling by Activin
130872	NA	False	True	NA
131118	DNAJC19	False	True	Mitochondrial protein import
131616	NA	False	True	NA
131831	ERICH6	False	True	NA
131890	NA	False	True	Inactivation, recovery and regulation of the phototransduction cascade
132001	TAMM41	False	True	NA
132158	GLYCTK	False	True	Fructose catabolism
132789	GNPDA2	False	True	Glycolysis
132864	CPEB2	False	True	NA
133022	NA	False	True	NA
133746	NA	False	True	Regulation of TP53 Activity through Methylation
134218	DNAJC21	False	True	NA
135228	NA	False	True	Platelet degranulation ;Post-translational modification: synthesis of GPI-anchored proteins
136319	MTPN	False	True	NA
138716	NA	False	True	NA
139324	NA	False	True	NA
139741	NA	False	True	NA
140459	ASB6	False	True	Neddylation;Antigen processing: Ubiquitination & Proteasome degradation
140465	MYL6B	False	True	Smooth Muscle Contraction
140467	NA	False	True	NA
140469	NA	False	True	NA
140576	S100A16	False	True	NA
140691	TRIM69	False	True	Antigen processing: Ubiquitination & Proteasome degradation
140738	TMEM37	False	True	NA
140739	UBE2F	False	True	Neddylation;Antigen processing: Ubiquitination & Proteasome degradation
140801	RPL10L	False	True	L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
140807	NA	False	True	Keratinization;Formation of the cornified envelope
140823	ROMO1	False	True	NA
140850	DEFB127	False	True	Beta defensins;Defensins
140885	SIRPA	False	True	Cell surface interactions at the vascular wall;Signal regulatory protein family interactions;Signal regulatory protein family interactions;Neutrophil degranulation
142684	RAB40A	False	True	RAB geranylgeranylation
143244	EIF5AL1	False	True	NA
143471	PSMA8	False	True	Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Antigen processing: Ubiquitination & Proteasome degradation
143630	NA	False	True	NA
143884	CWF19L2	False	True	NA
144097	C11orf84	False	True	NA
144110	NA	False	True	NA
144404	TMEM120B	False	True	NA
144406	NA	False	True	NA
144501	NA	True	False	Keratinization;Formation of the cornified envelope
144568	NA	True	False	NA
144699	FBXL14	False	True	Neddylation;Antigen processing: Ubiquitination & Proteasome degradation
144983	HNRNPA1L2	False	True	NA
145264	SERPINA12	True	True	NA
145946	SPATA8	False	True	NA
147007	TMEM199	False	True	NA
147687	ZNF417	False	True	Generic Transcription Pathway
147700	KLC3	False	True	MHC class II antigen presentation;RHO GTPases activate KTN1;COPI-dependent Golgi-to-ER retrograde traffic;Kinesins
147746	HIPK4	False	True	NA
147872	CCDC155	False	True	NA
148266	NA	False	True	Generic Transcription Pathway
148281	SYT6	False	True	NA
148867	NA	False	True	Insulin processing;Zinc efflux and compartmentalization by the SLC30 family
149111	NA	False	True	COPII-mediated vesicle transport;Cargo concentration in the ER
149371	EXOC8	False	True	Translocation of SLC2A4 (GLUT4) to the plasma membrane;Insulin processing;VxPx cargo-targeting to cilium
149420	PDIK1L	False	True	NA
149950	NA	False	True	NA
150094	SIK1	False	True	Circadian Clock
150275	CCDC117	False	True	NA
150353	NA	False	True	NA
150483	TEKT4	False	True	NA
150684	COMMD1	False	True	Neddylation
151011	SEPT10	False	True	NA
151230	NA	False	True	NA
151246	SGOL2	False	True	Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase
151254	ALS2CR11	False	True	NA
151393	RMDN2	False	True	NA
152110	NA	False	True	NA
152137	CCDC50	False	True	NA
152756	NA	False	True	NA
153769	SH3RF2	False	True	NA
154754	NA	False	True	NA
154796	AMOT	False	True	Signaling by Hippo
155030	gag	False	True	Uncoating of the HIV Virion;Budding and maturation of HIV virion;Integration of provirus;Early Phase of HIV Life Cycle;Minus-strand DNA synthesis;Plus-strand DNA synthesis;2-LTR circle formation;Binding and entry of HIV virion;Membrane binding and targetting of GAG proteins;Synthesis And Processing Of GAG, GAGPOL Polyproteins;Assembly Of The HIV Virion;Integration of viral DNA into host genomic DNA;Autointegration results in viral DNA circles;APOBEC3G mediated resistance to HIV-1 infection;Vpr-mediated nuclear import of PICs
157285	SGK223	False	True	NA
157378	TMEM65	False	True	NA
157680	NA	False	True	NA
157753	NA	False	True	NA
158787	RIBC1	False	True	NA
158866	NA	False	True	NA
159989	CCDC67	False	True	NA
160140	C11orf65	False	True	NA
160287	LDHAL6A	False	True	Pyruvate metabolism
160760	PPTC7	False	True	NA
161142	FAM71D	False	True	NA
164127	CCDC185	False	True	NA
165721	DNAJB8	False	True	NA
166614	DCLK2	False	True	NA
166793	ZBTB49	False	True	NA
166929	NA	False	True	Sphingolipid de novo biosynthesis
167465	NA	False	True	NA
167838	TXLNB	False	True	NA
168400	DDX53	False	True	NA
169026	SLC30A8	False	True	Insulin processing;Zinc efflux and compartmentalization by the SLC30 family
169714	QSOX2	False	True	NA
170082	TCEANC	False	True	NA
170394	NA	False	True	NA
170954	PPP1R18	False	True	NA
171024	SYNPO2	False	True	NA
171483	FAM9B	False	True	NA
196051	PPAPDC1A	False	True	Role of phospholipids in phagocytosis
196374	NA	True	False	Keratinization;Formation of the cornified envelope
196549	NA	False	True	NA
199953	NA	False	True	NA
199990	C1orf86	False	True	Fanconi Anemia Pathway
200081	TXLNA	False	True	Other interleukin signaling
200205	IBA57	False	True	NA
201161	CENPV	False	True	NA
201163	FLCN	False	True	NA
201164	NA	False	True	Synthesis of PG;Synthesis of PA;PIWI-interacting RNA (piRNA) biogenesis
201181	ZNF385C	False	True	NA
202459	OSTCP1	False	True	NA
202559	KHDRBS2	False	True	PTK6 Regulates Proteins Involved in RNA Processing
203062	TSNARE1	False	True	NA
203068	TUBB	False	True	Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;Neutrophil degranulation;AURKA Activation by TPX2
206338	NA	False	True	NA
219749	NA	False	True	Generic Transcription Pathway
219854	TMEM218	False	True	NA
219988	PATL1	False	True	mRNA decay by 5' to 3' exoribonuclease;mRNA decay by 5' to 3' exoribonuclease
220717	RPLP0P6	False	True	NA
220988	HNRNPA3	False	True	mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA
221092	HNRNPUL2	False	True	NA
221443	OARD1	False	True	NA
221927	BRAT1	False	True	NA
221938	NA	False	True	NA
222229	LRWD1	False	True	NA
222235	FBXL13	False	True	Neddylation;Antigen processing: Ubiquitination & Proteasome degradation
222484	LNX2	False	True	NA
222662	LHFPL5	False	True	NA
225689	MAPK15	False	True	NA
253143	NA	False	True	NA
253827	MSRB3	False	True	Protein repair
253943	YTHDF3	False	True	NA
254359	NA	False	True	NA
254428	NA	False	True	Metal ion SLC transporters
254879	NA	False	True	Olfactory Signaling Pathway
255189	NA	False	True	Acyl chain remodelling of PC;Acyl chain remodelling of PS;Acyl chain remodelling of PE;Acyl chain remodelling of PI;Acyl chain remodelling of PG;Hydrolysis of LPC
255394	TCP11L2	False	True	NA
257000	TINCR	False	True	NA
257240	KLHL34	False	True	NA
259217	NA	False	True	Regulation of HSF1-mediated heat shock response
259232	NALCN	False	True	Stimuli-sensing channels
261726	TIPRL	False	True	NA
282974	STK32C	False	True	NA
283078	MKX	False	True	NA
283160	NA	False	True	Olfactory Signaling Pathway
283165	NA	False	True	NA
283209	PGM2L1	False	True	Glycogen synthesis;Glycolysis;Glycogen breakdown (glycogenolysis);Galactose catabolism
283237	TTC9C	False	True	NA
283385	MORN3	False	True	NA
283431	NA	False	True	NA
283455	KSR2	False	True	MAP2K and MAPK activation;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF
283458	NA	False	True	NA
283742	FAM98B	False	True	tRNA processing in the nucleus
283870	NA	False	True	NA
284058	KANSL1	False	True	HATs acetylate histones
284069	NA	False	True	NA
284076	TTLL6	False	True	Carboxyterminal post-translational modifications of tubulin
284086	NEK8	False	True	NA
284217	LAMA1	False	True	Laminin interactions;Laminin interactions;Non-integrin membrane-ECM interactions;ECM proteoglycans;L1CAM interactions;MET activates PTK2 signaling
284276	NA	False	True	NA
284403	WDR62	False	True	NA
284415	NA	False	True	NA
284418	FAM71E2	False	True	NA
284618	NA	False	True	NA
285093	NA	False	True	Olfactory Signaling Pathway
285753	CEP57L1	False	True	NA
286077	FAM83H	False	True	NA
286262	TPRN	False	True	NA
286410	ATP11C	False	True	Ion transport by P-type ATPases
286451	NA	False	True	Golgi Associated Vesicle Biogenesis
286887	NA	False	True	Keratinization;Formation of the cornified envelope
287015	TRIM42	False	True	NA
317649	EIF4E3	False	True	ISG15 antiviral mechanism
317719	KLHL10	False	True	NA
317772	HIST2H2AB	False	True	HDACs deacetylate histones;HATs acetylate histones;HATs acetylate histones;RMTs methylate histone arginines;UCH proteinases;Ub-specific processing proteases;Metalloprotease DUBs
319101	NA	False	True	Keratinization;Formation of the cornified envelope
337879	NA	False	True	Keratinization
337972	NA	False	True	Keratinization
338657	CCDC84	False	True	NA
338785	NA	False	True	Keratinization;Formation of the cornified envelope
339287	MSL1	False	True	HATs acetylate histones
339302	CPLX4	False	True	NA
340156	MYLK4	False	True	NA
340348	TSPAN33	False	True	Amyloid fiber formation
340359	KLHL38	False	True	NA
342667	STAC2	False	True	NA
342979	NA	False	True	NA
345651	ACTBL2	False	True	NA
345778	NA	False	True	NA
347517	RAB41	False	True	Intra-Golgi traffic;RAB geranylgeranylation
347688	TUBB8	False	True	Translocation of SLC2A4 (GLUT4) to the plasma membrane;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;Gap junction assembly;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HSP90 chaperone cycle for steroid hormone receptors (SHR);Recruitment of NuMA to mitotic centrosomes;Recycling pathway of L1;Recycling pathway of L1;Cilium Assembly;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;Carboxyterminal post-translational modifications of tubulin;Carboxyterminal post-translational modifications of tubulin;Activation of AMPK downstream of NMDARs;Kinesins
347733	TUBB2B	False	True	Translocation of SLC2A4 (GLUT4) to the plasma membrane;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;Gap junction assembly;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HSP90 chaperone cycle for steroid hormone receptors (SHR);Recruitment of NuMA to mitotic centrosomes;Prefoldin mediated transfer of substrate  to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Post-chaperonin tubulin folding pathway;Recycling pathway of L1;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;Carboxyterminal post-translational modifications of tubulin;Carboxyterminal post-translational modifications of tubulin;Activation of AMPK downstream of NMDARs;Kinesins
347734	NA	False	True	Transport and synthesis of PAPS;Transport of nucleotide sugars
348110	NA	False	True	NA
353142	NA	False	True	Formation of the cornified envelope
373156	GSTK1	False	True	Glutathione conjugation;Peroxisomal protein import;Peroxisomal protein import
374454	NA	False	True	Keratinization;Formation of the cornified envelope
374897	NA	True	False	NA
375035	NA	False	True	NA
375056	MIA3	False	True	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Cargo concentration in the ER;Post-translational protein phosphorylation
375248	NA	False	True	NA
375484	SIMC1	False	True	NA
375593	NA	False	True	NA
378108	TRIM74	False	True	NA
378884	NHLRC1	False	True	Glycogen synthesis;Myoclonic epilepsy of Lafora
386617	NA	False	True	NA
386675	KRTAP10-7	False	True	Keratinization
386676	KRTAP10-9	False	True	Keratinization
386682	KRTAP10-3	False	True	Keratinization
387082	SUMO4	False	True	NA
387521	TMEM189	False	True	NA
387522	TMEM189-UBE2V1	False	True	NOD1/2 Signaling Pathway;TICAM1, RIP1-mediated IKK complex recruitment ;Downstream TCR signaling;FCERI mediated NF-kB activation;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;activated TAK1 mediates p38 MAPK activation;JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1;CLEC7A (Dectin-1) signaling;Interleukin-1 signaling;IRAK1 recruits IKK complex;IKK complex recruitment mediated by RIP1;TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling;IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation;Antigen processing: Ubiquitination & Proteasome degradation
387923	NA	False	True	NA
388524	NA	False	True	NA
388591	RNF207	False	True	NA
388677	NOTCH2NL	False	True	NA
388697	NA	True	False	Neutrophil degranulation
388698	NA	True	False	Neutrophil degranulation
388818	KRTAP26-1	False	True	Keratinization
389084	NA	False	True	NA
389362	PSMG4	False	True	NA
389840	MAP3K15	False	True	NA
390535	NA	False	True	NA
390637	GDPGP1	False	True	NA
390916	NA	False	True	Peroxisomal lipid metabolism;Peroxisomal protein import;Peroxisomal protein import
397519	NA	False	True	NA
399396	nedd4l	False	True	NA
399687	MYO18A	False	True	Signaling by cytosolic FGFR1 fusion mutants;Signaling by FGFR1 in disease
401152	C4orf3	False	True	NA
401466	NA	False	True	NA
401541	CENPP	False	True	Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Deposition of new CENPA-containing nucleosomes at the centromere;Mitotic Prometaphase
404734	NA	False	True	NA
414059	NA	False	True	NA
414318	C9orf106	False	True	NA
415116	NA	False	True	NA
440434	NA	False	True	NA
440482	NA	False	True	NA
440574	MINOS1	False	True	Cristae formation
440686	NA	False	True	NA
440915	POTEKP	False	True	NA
441282	NA	False	True	Estrogen biosynthesis
441518	NA	False	True	NA
448834	NA	True	False	NA
493856	CISD2	False	True	NA
497049	NA	False	True	NA
542767	NA	False	True	NA
548596	CKMT1A	False	True	Creatine metabolism
553115	PEF1	False	True	NA
554313	NA	False	True	Meiotic synapsis;Packaging Of Telomere Ends;Pre-NOTCH Transcription and Translation;Formation of the beta-catenin:TCF transactivating complex;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;HDACs deacetylate histones;PKMTs methylate histone lysines;HDMs demethylate histones;HATs acetylate histones;HATs acetylate histones;RMTs methylate histone arginines;SIRT1 negatively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;NoRC negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;SUMOylation of chromatin organization proteins;B-WICH complex positively regulates rRNA expression;DNA methylation;Transcriptional regulation by small RNAs;Activation of anterior HOX genes in hindbrain development during early embryogenesis;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Processing of DNA double-strand break ends;Deposition of new CENPA-containing nucleosomes at the centromere;G2/M DNA damage checkpoint;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Estrogen-dependent gene expression;Meiotic recombination;Amyloid fiber formation
574040	NA	False	True	NA
643752	NA	False	True	NA
645432	NA	False	True	NA
653234	NA	False	True	NA
653268	NA	False	True	NA
653404	FOXD4L6	False	True	NA
653499	NA	True	False	NA
653505	NA	False	True	NA
653509	SFTPA1	False	True	Toll Like Receptor 4 (TLR4) Cascade;Toll Like Receptor TLR1:TLR2 Cascade;Signal regulatory protein family interactions;Surfactant metabolism;Regulation of TLR by endogenous ligand;Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5);Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)
654364	NME1-NME2	False	True	Interconversion of nucleotide di- and triphosphates;Neutrophil degranulation
727897	MUC5B	True	True	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC);Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS);Defective GALNT12 causes colorectal cancer 1 (CRCS1);Dectin-2 family;O-linked glycosylation of mucins;Termination of O-glycan biosynthesis
728642	CDK11A	False	True	Recruitment of mitotic centrosome proteins and complexes
729092	NA	False	True	NA
851752	SUP35	False	True	NA
853344	GSH1	False	True	NA
854708	NA	False	True	NA
855054	NA	False	True	NA
951476	NA	False	True	NA
2540051	NA	False	True	NA
100009506	ACTA1	False	True	NA
100128588	LOC100128588	False	True	NA
100129271	NA	True	False	NA
100342572	LOC100342572	False	True	NA
100506742	CASP12	False	True	NA
100507436	MICA	False	True	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
100526693	ARPC4-TTLL3	False	True	NA
100526737	NA	False	True	RUNX2 regulates bone development
100532736	MINOS1-NBL1	False	True	NA
100996928	NA	False	True	NA
101929876	LOC101929876	False	True	NA
101930400	LOC101930400	False	True	NA
102288414	NA	False	True	NA
NA	NA	True	False	NA
author	proteore
date	Thu, 06 Feb 2020 08:28:04 -0500
parents	99f6a94c1ade
children