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author | proteore |
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date | Fri, 24 Jan 2020 05:21:52 -0500 |
parents | 99f6a94c1ade |
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Entrez gene ID Official Symbol Interactor Present in user input ids ID present in Biogrid Human Pathway 2 A2M False True Platelet degranulation ;Intrinsic Pathway of Fibrin Clot Formation;Degradation of the extracellular matrix;Rho GTPase cycle;HDL assembly 12 SERPINA3 True True Platelet degranulation ;Neutrophil degranulation 15 AANAT False True Serotonin and melatonin biosynthesis 16 AARS False True Cytosolic tRNA aminoacylation 18 ABAT False True Degradation of GABA 25 ABL1 False True Regulation of actin dynamics for phagocytic cup formation;CDO in myogenesis;CDO in myogenesis;Role of ABL in ROBO-SLIT signaling;Role of ABL in ROBO-SLIT signaling;RHO GTPases Activate WASPs and WAVEs;HDR through Single Strand Annealing (SSA);Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Cyclin D associated events in G1;RUNX1 regulates transcription of genes involved in differentiation of HSCs;RUNX2 regulates osteoblast differentiation;Factors involved in megakaryocyte development and platelet production 27 ABL2 False True Role of ABL in ROBO-SLIT signaling;Role of ABL in ROBO-SLIT signaling 30 ACAA1 False True alpha-linolenic acid (ALA) metabolism;Beta-oxidation of very long chain fatty acids;Neutrophil degranulation;Peroxisomal protein import;Peroxisomal protein import;TYSND1 cleaves peroxisomal proteins 31 ACACA False True ChREBP activates metabolic gene expression;Biotin transport and metabolism;Import of palmitoyl-CoA into the mitochondrial matrix;Activation of gene expression by SREBF (SREBP);Defective HLCS causes multiple carboxylase deficiency;Fatty acyl-CoA biosynthesis 34 ACADM False True PPARA activates gene expression;mitochondrial fatty acid beta-oxidation of unsaturated fatty acids;Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA;Beta oxidation of octanoyl-CoA to hexanoyl-CoA 38 ACAT1 False True Branched-chain amino acid catabolism;Utilization of Ketone Bodies;Synthesis of Ketone Bodies 39 ACAT2 False True Cholesterol biosynthesis 48 ACO1 False True Iron uptake and transport 50 ACO2 False True Mitochondrial protein import;Citric acid cycle (TCA cycle) 58 ACTA1 False True Striated Muscle Contraction 59 ACTA2 False True Smooth Muscle Contraction;NOTCH4 Intracellular Domain Regulates Transcription 60 ACTB False True Translocation of SLC2A4 (GLUT4) to the plasma membrane;Gap junction degradation;Formation of annular gap junctions;Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;HATs acetylate histones;Prefoldin mediated transfer of substrate to CCT/TriC;Folding of actin by CCT/TriC;EPHB-mediated forward signaling;EPH-ephrin mediated repulsion of cells;Adherens junctions interactions;Adherens junctions interactions;Recycling pathway of L1;Recycling pathway of L1;VEGFA-VEGFR2 Pathway;Interaction between L1 and Ankyrins;Interaction between L1 and Ankyrins;Cell-extracellular matrix interactions;B-WICH complex positively regulates rRNA expression;RHO GTPases activate IQGAPs;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate Formins;RHO GTPases Activate Formins;MAP2K and MAPK activation;UCH proteinases;DNA Damage Recognition in GG-NER;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF;Clathrin-mediated endocytosis;Factors involved in megakaryocyte development and platelet production 70 ACTC1 False True Striated Muscle Contraction 71 ACTG1 True True Translocation of SLC2A4 (GLUT4) to the plasma membrane;Gap junction degradation;Formation of annular gap junctions;Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;EPHB-mediated forward signaling;EPH-ephrin mediated repulsion of cells;Adherens junctions interactions;Adherens junctions interactions;Recycling pathway of L1;Recycling pathway of L1;VEGFA-VEGFR2 Pathway;Interaction between L1 and Ankyrins;Interaction between L1 and Ankyrins;Cell-extracellular matrix interactions;RHO GTPases activate IQGAPs;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate Formins;RHO GTPases Activate Formins;MAP2K and MAPK activation;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF;Clathrin-mediated endocytosis 81 ACTN4 True True Platelet degranulation ;Nephrin family interactions 87 ACTN1 False True Platelet degranulation ;Syndecan interactions;Nephrin family interactions;Regulation of cytoskeletal remodeling and cell spreading by IPP complex components 88 ACTN2 False True Platelet degranulation ;Nephrin family interactions;Striated Muscle Contraction;Unblocking of NMDA receptors, glutamate binding and activation;Unblocking of NMDA receptors, glutamate binding and activation;Ras activation upon Ca2+ influx through NMDA receptor;RAF/MAP kinase cascade;Negative regulation of NMDA receptor-mediated neuronal transmission;Long-term potentiation 89 ACTN3 False True Nephrin family interactions;Striated Muscle Contraction 91 ACVR1B False True Signaling by NODAL;Regulation of signaling by NODAL;Signaling by Activin 93 ACVR2B False True Signaling by NODAL;Regulation of signaling by NODAL;Signaling by Activin;Signaling by Activin;Signaling by BMP 95 ACY1 False True Aflatoxin activation and detoxification;Defective ACY1 causes encephalopathy 115 NA False True Glucagon signaling in metabolic regulation;PKA activation;PKA activation in glucagon signalling;Adenylate cyclase activating pathway;Adenylate cyclase inhibitory pathway;Adenylate cyclase inhibitory pathway;G alpha (s) signalling events;G alpha (s) signalling events;G alpha (i) signalling events;G alpha (z) signalling events;G alpha (z) signalling events;Vasopressin regulates renal water homeostasis via Aquaporins;Hedgehog 'off' state 119 ADD2 False True Miscellaneous transport and binding events 120 NA False True Miscellaneous transport and binding events 125 ADH1B False True Ethanol oxidation 127 ADH4 False True RA biosynthesis pathway;Ethanol oxidation 132 ADK False True Purine salvage 140 ADORA3 False True Adenosine P1 receptors;G alpha (i) signalling events 142 PARP1 False True POLB-Dependent Long Patch Base Excision Repair;Downregulation of SMAD2/3:SMAD4 transcriptional activity;SUMOylation of DNA damage response and repair proteins;HDR through MMEJ (alt-NHEJ);DNA Damage Recognition in GG-NER;Formation of Incision Complex in GG-NER;Dual Incision in GG-NER 147 ADRA1B False True Adrenoceptors;G alpha (q) signalling events;G alpha (12/13) signalling events 157 ADRBK2 False True G alpha (s) signalling events;Cargo recognition for clathrin-mediated endocytosis 158 ADSL False True Purine ribonucleoside monophosphate biosynthesis 159 ADSS False True Purine ribonucleoside monophosphate biosynthesis 160 AP2A1 False True Nef Mediated CD4 Down-regulation;Retrograde neurotrophin signalling;Retrograde neurotrophin signalling;Nef Mediated CD8 Down-regulation;MHC class II antigen presentation;EPH-ephrin mediated repulsion of cells;Trafficking of GluR2-containing AMPA receptors;Recycling pathway of L1;Recycling pathway of L1;WNT5A-dependent internalization of FZD4;WNT5A-dependent internalization of FZD2, FZD5 and ROR2;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;VLDLR internalisation and degradation;LDL clearance 163 AP2B1 False True Nef Mediated CD4 Down-regulation;Retrograde neurotrophin signalling;Retrograde neurotrophin signalling;Nef Mediated CD8 Down-regulation;MHC class II antigen presentation;EPH-ephrin mediated repulsion of cells;Trafficking of GluR2-containing AMPA receptors;Recycling pathway of L1;Recycling pathway of L1;WNT5A-dependent internalization of FZD4;WNT5A-dependent internalization of FZD2, FZD5 and ROR2;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;VLDLR internalisation and degradation;LDL clearance 164 AP1G1 False True Nef mediated downregulation of MHC class I complex cell surface expression;MHC class II antigen presentation;Lysosome Vesicle Biogenesis;Golgi Associated Vesicle Biogenesis 166 AES False True Repression of WNT target genes 175 AGA True True Neutrophil degranulation 178 AGL False True Neutrophil degranulation;Glycogen breakdown (glycogenolysis) 189 NA False True Glyoxylate metabolism and glycine degradation;Peroxisomal protein import;Peroxisomal protein import 191 AHCY False True Methylation;Sulfur amino acid metabolism;Metabolism of ingested SeMet, Sec, MeSec into H2Se;Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) 196 AHR False True PPARA activates gene expression;Phase I - Functionalization of compounds;Endogenous sterols;Xenobiotics;Aryl hydrocarbon receptor signalling 197 AHSG False True Platelet degranulation ;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Neutrophil degranulation;Post-translational protein phosphorylation 204 AK2 False True Interconversion of nucleotide di- and triphosphates 207 AKT1 False True Activation of BAD and translocation to mitochondria ;PIP3 activates AKT signaling;PIP3 activates AKT signaling;Downregulation of ERBB2:ERBB3 signaling;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation;mTOR signalling;AKT phosphorylates targets in the cytosol;AKT phosphorylates targets in the cytosol;AKT phosphorylates targets in the nucleus;Negative regulation of the PI3K/AKT network;eNOS activation;AKT-mediated inactivation of FOXO1A;Integrin alphaIIb beta3 signaling;Deactivation of the beta-catenin transactivating complex;CD28 dependent PI3K/Akt signaling;CTLA4 inhibitory signaling;G beta:gamma signalling through PI3Kgamma;Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA;KSRP (KHSRP) binds and destabilizes mRNA;VEGFR2 mediated vascular permeability;TP53 Regulates Metabolic Genes;Constitutive Signaling by AKT1 E17K in Cancer;Interleukin-4 and Interleukin-13 signaling;Regulation of TP53 Degradation;Regulation of TP53 Activity through Acetylation;Regulation of TP53 Activity through Association with Co-factors;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Cyclin E associated events during G1/S transition ;Cyclin A:Cdk2-associated events at S phase entry;PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1;RAB GEFs exchange GTP for GDP on RABs;RUNX2 regulates genes involved in cell migration;Regulation of PTEN stability and activity;Negative regulation of NOTCH4 signaling;Regulation of localization of FOXO transcription factors 208 AKT2 False True Activation of BAD and translocation to mitochondria ;PIP3 activates AKT signaling;PIP3 activates AKT signaling;Downregulation of ERBB2:ERBB3 signaling;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Activation of AKT2;PDE3B signalling;Inhibition of TSC complex formation by PKB;AKT phosphorylates targets in the cytosol;AKT phosphorylates targets in the cytosol;AKT phosphorylates targets in the nucleus;Negative regulation of the PI3K/AKT network;AKT-mediated inactivation of FOXO1A;Deactivation of the beta-catenin transactivating complex;CD28 dependent PI3K/Akt signaling;CTLA4 inhibitory signaling;G beta:gamma signalling through PI3Kgamma;VEGFR2 mediated vascular permeability;TP53 Regulates Metabolic Genes;Constitutive Signaling by AKT1 E17K in Cancer;Regulation of TP53 Degradation;Regulation of TP53 Activity through Acetylation;Regulation of TP53 Activity through Association with Co-factors;Cyclin E associated events during G1/S transition ;Cyclin A:Cdk2-associated events at S phase entry;RAB GEFs exchange GTP for GDP on RABs;RUNX2 regulates genes involved in cell migration;Regulation of PTEN stability and activity;Regulation of localization of FOXO transcription factors 210 ALAD False True Heme biosynthesis;Neutrophil degranulation 213 ALB True True Platelet degranulation ;Recycling of bile acids and salts;Scavenging of heme from plasma;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR);Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR);Transport of organic anions;Post-translational protein phosphorylation;HDL remodeling 214 ALCAM False True L1CAM interactions 217 ALDH2 False True Metabolism of serotonin;Ethanol oxidation 219 ALDH1B1 False True Ethanol oxidation 224 ALDH3A2 False True Sphingolipid de novo biosynthesis;Alpha-oxidation of phytanate 226 ALDOA True True Platelet degranulation ;Neutrophil degranulation;Glycolysis;Gluconeogenesis 229 ALDOB False True Hereditary fructose intolerance;Glycolysis;Gluconeogenesis;Fructose catabolism 230 ALDOC True True Neutrophil degranulation;Glycolysis;Gluconeogenesis 231 AKR1B1 False True Pregnenolone biosynthesis;Fructose biosynthesis 238 ALK False True NA 242 NA True False Synthesis of 12-eicosatetraenoic acid derivatives 248 ALPI False True Synthesis of PA;Post-translational modification: synthesis of GPI-anchored proteins;Digestion 262 AMD1 False True Metabolism of polyamines 267 AMFR False True N-glycan trimming in the ER and Calnexin/Calreticulin cycle;ER Quality Control Compartment (ERQC) 269 AMHR2 False True Signaling by BMP 272 NA False True Neutrophil degranulation;Purine salvage 274 BIN1 False True Clathrin-mediated endocytosis 275 NA False True Glycine degradation 276 AMY1A True True Digestion of dietary carbohydrate 277 NA True False Digestion of dietary carbohydrate 278 NA True False Digestion of dietary carbohydrate 286 ANK1 False True Interaction between L1 and Ankyrins;Interaction between L1 and Ankyrins;NrCAM interactions;CHL1 interactions;Neurofascin interactions;Neurofascin interactions;COPI-mediated anterograde transport 292 SLC25A5 False True Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization;Regulation of insulin secretion 293 SLC25A6 False True Mitochondrial protein import;Mitochondrial protein import;Influenza Virus Induced Apoptosis;Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization;Regulation of insulin secretion 301 ANXA1 True True G alpha (q) signalling events;G alpha (i) signalling events;Formyl peptide receptors bind formyl peptides and many other ligands;Smooth Muscle Contraction;Interleukin-4 and Interleukin-13 signaling 302 ANXA2 True True Smooth Muscle Contraction;Neutrophil degranulation;Dissolution of Fibrin Clot;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 307 ANXA4 False True NA 308 ANXA5 False True Platelet degranulation 309 ANXA6 False True Smooth Muscle Contraction 310 ANXA7 False True NA 312 ANXA13 False True NA 317 APAF1 False True Formation of apoptosome;Activation of caspases through apoptosome-mediated cleavage;SMAC (DIABLO) binds to IAPs ;SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ;Neutrophil degranulation;TP53 Regulates Transcription of Caspase Activators and Caspases;Transcriptional Regulation by E2F6;Regulation of the apoptosome activity;Regulation of the apoptosome activity 322 APBB1 False True Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 324 APC False True Apoptotic cleavage of cellular proteins;Degradation of beta-catenin by the destruction complex;Beta-catenin phosphorylation cascade;Deactivation of the beta-catenin transactivating complex;Disassembly of the destruction complex and recruitment of AXIN to the membrane;Disassembly of the destruction complex and recruitment of AXIN to the membrane;Misspliced GSK3beta mutants stabilize beta-catenin;S33 mutants of beta-catenin aren't phosphorylated;S37 mutants of beta-catenin aren't phosphorylated;S45 mutants of beta-catenin aren't phosphorylated;T41 mutants of beta-catenin aren't phosphorylated;APC truncation mutants are not K63 polyubiquitinated;APC truncation mutants have impaired AXIN binding;AXIN missense mutants destabilize the destruction complex;Truncations of AMER1 destabilize the destruction complex;Ovarian tumor domain proteases 328 APEX1 False True Displacement of DNA glycosylase by APEX1;POLB-Dependent Long Patch Base Excision Repair;Resolution of AP sites via the multiple-nucleotide patch replacement pathway;PCNA-Dependent Long Patch Base Excision Repair;Abasic sugar-phosphate removal via the single-nucleotide replacement pathway;Resolution of Abasic Sites (AP sites) 332 BIRC5 False True Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;SUMOylation of DNA replication proteins;RHO GTPases Activate Formins;Interleukin-4 and Interleukin-13 signaling;TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain;Mitotic Prometaphase;Neddylation 333 APLP1 False True NA 334 APLP2 False True Platelet degranulation ;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation 335 APOA1 False True Platelet degranulation ;ABC transporters in lipid homeostasis;PPARA activates gene expression;Scavenging of heme from plasma;Scavenging by Class B Receptors;Scavenging by Class B Receptors;Scavenging by Class A Receptors;Scavenging by Class A Receptors;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation;Chylomicron assembly;HDL assembly;Chylomicron remodeling;HDL clearance;HDL remodeling;Retinoid metabolism and transport;Retinoid metabolism and transport;Amyloid fiber formation 336 APOA2 False True PPARA activates gene expression;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation;Chylomicron assembly;Chylomicron remodeling;Retinoid metabolism and transport;Retinoid metabolism and transport 337 NA False True NA 338 APOB False True Cell surface interactions at the vascular wall;Scavenging by Class B Receptors;Scavenging by Class B Receptors;Scavenging by Class A Receptors;Scavenging by Class A Receptors;Scavenging by Class F Receptors;Scavenging by Class F Receptors;Scavenging by Class H Receptors;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Platelet sensitization by LDL;Regulation of TLR by endogenous ligand;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;VLDL assembly;Post-translational protein phosphorylation;Chylomicron assembly;Chylomicron remodeling;Chylomicron clearance;Chylomicron clearance;LDL clearance;LDL clearance;LDL remodeling;VLDL clearance;VLDL clearance;Retinoid metabolism and transport;Retinoid metabolism and transport 341 APOC1 False True VLDL assembly;VLDL clearance;VLDL clearance 344 APOC2 False True Chylomicron assembly;Assembly of active LPL and LIPC lipase complexes;Chylomicron remodeling;HDL remodeling;Retinoid metabolism and transport;Retinoid metabolism and transport 345 APOC3 False True Chylomicron assembly;Chylomicron remodeling;HDL remodeling;Retinoid metabolism and transport;Retinoid metabolism and transport 347 APOD True True Transport of fatty acids 348 APOE False True Scavenging by Class A Receptors;Scavenging by Class A Receptors;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors;Post-translational protein phosphorylation;Chylomicron assembly;Chylomicron remodeling;Chylomicron clearance;Chylomicron clearance;HDL remodeling;Retinoid metabolism and transport;Retinoid metabolism and transport 350 APOH False True Platelet degranulation 351 APP False True Platelet degranulation ;ECM proteoglycans;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);G alpha (q) signalling events;G alpha (i) signalling events;Lysosome Vesicle Biogenesis;Formyl peptide receptors bind formyl peptides and many other ligands;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;The NLRP3 inflammasome;Advanced glycosylation endproduct receptor signaling;Advanced glycosylation endproduct receptor signaling;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Post-translational protein phosphorylation;TRAF6 mediated NF-kB activation;Amyloid fiber formation 353 APRT False True Neutrophil degranulation;Purine salvage 354 KLK3 False True Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 357 NA False True NA 358 AQP1 False True Erythrocytes take up carbon dioxide and release oxygen;Erythrocytes take up oxygen and release carbon dioxide;Vasopressin regulates renal water homeostasis via Aquaporins;Passive transport by Aquaporins 360 AQP3 False True Vasopressin regulates renal water homeostasis via Aquaporins;Passive transport by Aquaporins 367 AR False True HSP90 chaperone cycle for steroid hormone receptors (SHR);Nuclear Receptor transcription pathway;SUMOylation of intracellular receptors;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Ub-specific processing proteases;RUNX2 regulates osteoblast differentiation;RUNX2 regulates osteoblast differentiation 369 ARAF False True RAF activation;MAP2K and MAPK activation;Negative regulation of MAPK pathway;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF 372 ARCN1 False True COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic 373 TRIM23 False True NA 378 ARF4 False True VxPx cargo-targeting to cilium;VxPx cargo-targeting to cilium;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic 381 ARF5 False True COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic 383 ARG1 True True Neutrophil degranulation;Urea cycle 384 ARG2 False True Urea cycle 387 RHOA False True GPVI-mediated activation cascade;Axonal growth inhibition (RHOA activation);Rho GTPase cycle;PI3K/AKT activation;Axonal growth stimulation;TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);G beta:gamma signalling through PI3Kgamma;EPHB-mediated forward signaling;EPHB-mediated forward signaling;EPHA-mediated growth cone collapse;EPHA-mediated growth cone collapse;PCP/CE pathway;G alpha (12/13) signalling events;Sema4D mediated inhibition of cell attachment and migration;Sema4D induced cell migration and growth-cone collapse;Sema4D induced cell migration and growth-cone collapse;VEGFA-VEGFR2 Pathway;RHO GTPases activate PKNs;RHO GTPases activate CIT;RHO GTPases activate CIT;RHO GTPases activate KTN1;RHO GTPases Activate ROCKs;RHO GTPases Activate ROCKs;RHO GTPases Activate Formins;RHO GTPases Activate Rhotekin and Rhophilins;RHO GTPases Activate Rhotekin and Rhophilins;Ovarian tumor domain proteases;ERBB2 Regulates Cell Motility;Neutrophil degranulation;PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases;SLIT2:ROBO1 increases RHOA activity 390 RND3 False True NA 396 ARHGDIA False True Axonal growth inhibition (RHOA activation);Rho GTPase cycle;Axonal growth stimulation 398 ARHGDIG False True Rho GTPase cycle 405 ARNT False True Regulation of gene expression by Hypoxia-inducible Factor;PPARA activates gene expression;Phase I - Functionalization of compounds;Endogenous sterols;Xenobiotics;Aryl hydrocarbon receptor signalling 406 ARNTL False True BMAL1:CLOCK,NPAS2 activates circadian gene expression;BMAL1:CLOCK,NPAS2 activates circadian gene expression;PPARA activates gene expression;Circadian Clock 427 ASAH1 False True Glycosphingolipid metabolism;Neutrophil degranulation 432 ASGR1 False True Asparagine N-linked glycosylation 439 ASNA1 False True XBP1(S) activates chaperone genes 440 ASNS False True ATF4 activates genes;Amino acid synthesis and interconversion (transamination) 444 ASPH False True Stimuli-sensing channels;Ion homeostasis 445 ASS1 False True Urea cycle 466 ATF1 False True CREB phosphorylation 467 ATF3 False True ATF4 activates genes 471 ATIC False True Purine ribonucleoside monophosphate biosynthesis 472 ATM False True DNA Damage/Telomere Stress Induced Senescence;Regulation of HSF1-mediated heat shock response;Autodegradation of the E3 ubiquitin ligase COP1;HDR through Single Strand Annealing (SSA);HDR through Homologous Recombination (HRR);Sensing of DNA Double Strand Breaks;Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA);Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Resolution of D-loop Structures through Holliday Junction Intermediates;Nonhomologous End-Joining (NHEJ);Homologous DNA Pairing and Strand Exchange;Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;TP53 Regulates Transcription of DNA Repair Genes;TP53 Regulates Transcription of Genes Involved in Cytochrome C Release;TP53 Regulates Transcription of Caspase Activators and Caspases;Regulation of TP53 Activity through Phosphorylation;Regulation of TP53 Degradation;Regulation of TP53 Activity through Methylation;G2/M DNA damage checkpoint;Stabilization of p53;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Meiotic recombination 475 ATOX1 False True Detoxification of Reactive Oxygen Species;Ion influx/efflux at host-pathogen interface 476 ATP1A1 False True Ion homeostasis;Ion transport by P-type ATPases 488 ATP2A2 False True Pre-NOTCH Processing in Golgi;Reduction of cytosolic Ca++ levels;Ion homeostasis;Ion transport by P-type ATPases 491 ATP2B2 False True Reduction of cytosolic Ca++ levels;Ion homeostasis;Ion transport by P-type ATPases 493 ATP2B4 False True Reduction of cytosolic Ca++ levels;Ion homeostasis;Ion transport by P-type ATPases 498 ATP5A1 True True Mitochondrial protein import;Formation of ATP by chemiosmotic coupling;Cristae formation 501 ALDH7A1 False True Choline catabolism;Lysine catabolism 506 ATP5B False True Mitochondrial protein import;Mitochondrial protein import;Formation of ATP by chemiosmotic coupling;Transcriptional activation of mitochondrial biogenesis;Cristae formation 509 ATP5C1 False True Formation of ATP by chemiosmotic coupling;Cristae formation 513 ATP5D False True Formation of ATP by chemiosmotic coupling;Cristae formation 514 ATP5E False True Formation of ATP by chemiosmotic coupling;Cristae formation 515 ATP5F1 False True Formation of ATP by chemiosmotic coupling;Cristae formation 521 ATP5I False True Formation of ATP by chemiosmotic coupling;Cristae formation 522 ATP5J False True Formation of ATP by chemiosmotic coupling;Cristae formation 523 ATP6V1A False True ROS, RNS production in phagocytes;Insulin receptor recycling;Transferrin endocytosis and recycling;Ion channel transport 525 ATP6V1B1 False True ROS, RNS production in phagocytes;Insulin receptor recycling;Transferrin endocytosis and recycling;Ion channel transport 526 ATP6V1B2 False True ROS, RNS production in phagocytes;Insulin receptor recycling;Transferrin endocytosis and recycling;Ion channel transport 527 ATP6V0C False True ROS, RNS production in phagocytes;Neutrophil degranulation;Insulin receptor recycling;Transferrin endocytosis and recycling;Ion channel transport 533 ATP6V0B False True ROS, RNS production in phagocytes;Insulin receptor recycling;Transferrin endocytosis and recycling;Ion channel transport 539 ATP5O False True Formation of ATP by chemiosmotic coupling;Cristae formation 545 ATR False True Meiotic synapsis;Activation of ATR in response to replication stress;Regulation of HSF1-mediated heat shock response;HDR through Single Strand Annealing (SSA);Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;Fanconi Anemia Pathway;TP53 Regulates Transcription of DNA Repair Genes;Regulation of TP53 Activity through Phosphorylation;G2/M DNA damage checkpoint 558 AXL False True VEGFA-VEGFR2 Pathway 563 AZGP1 True True Miscellaneous transport and binding events 572 BAD False True Activation of BAD and translocation to mitochondria ;Activation of BAD and translocation to mitochondria ;BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members;NRAGE signals death through JNK;AKT phosphorylates targets in the cytosol;Constitutive Signaling by AKT1 E17K in Cancer 573 BAG1 False True Regulation of HSF1-mediated heat shock response 581 BAX False True Release of apoptotic factors from the mitochondria;Activation, translocation and oligomerization of BAX;TP53 Regulates Transcription of Genes Involved in Cytochrome C Release;TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest;Transcriptional regulation by RUNX2;NTRK3 as a dependence receptor 587 BCAT2 False True Branched-chain amino acid catabolism 593 BCKDHA False True Glyoxylate metabolism and glycine degradation;Branched-chain amino acid catabolism 595 CCND1 False True SCF(Skp2)-mediated degradation of p27/p21;Pre-NOTCH Transcription and Translation;RMTs methylate histone arginines;Interleukin-4 and Interleukin-13 signaling;Ubiquitin-dependent degradation of Cyclin D1;Ubiquitin-dependent degradation of Cyclin D1;Cyclin D associated events in G1;PTK6 Regulates Cell Cycle;Transcriptional regulation by RUNX2;Regulation of RUNX1 Expression and Activity;RUNX3 regulates WNT signaling;RUNX3 regulates p14-ARF;Estrogen-dependent gene expression 596 BCL2 False True Activation of BAD and translocation to mitochondria ;BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members;Interleukin-4 and Interleukin-13 signaling;The NLRP1 inflammasome;Estrogen-dependent gene expression 599 BCL2L2 False True NA 604 BCL6 False True Interleukin-4 and Interleukin-13 signaling;TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain;FOXO-mediated transcription of cell death genes 613 BCR False True Signaling by cytosolic FGFR1 fusion mutants;Rho GTPase cycle;Signaling by FGFR1 in disease 622 BDH1 False True Utilization of Ketone Bodies;Synthesis of Ketone Bodies 629 CFB False True Alternative complement activation;Activation of C3 and C5;Regulation of Complement cascade 639 PRDM1 False True Regulation of TP53 Expression 640 BLK False True RUNX1 regulates transcription of genes involved in BCR signaling;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 641 BLM False True SUMOylation of DNA damage response and repair proteins;HDR through Single Strand Annealing (SSA);HDR through Homologous Recombination (HRR);Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA);Resolution of D-loop Structures through Holliday Junction Intermediates;Homologous DNA Pairing and Strand Exchange;Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;Regulation of TP53 Activity through Phosphorylation;G2/M DNA damage checkpoint;Meiotic recombination 642 BLMH True True Antigen processing: Ubiquitination & Proteasome degradation 655 BMP7 False True Molecules associated with elastic fibres 657 BMPR1A False True Signaling by BMP 660 BMX False True Apoptotic cleavage of cellular proteins;Synthesis of PIPs at the plasma membrane 663 BNIP2 False True CDO in myogenesis;CDO in myogenesis 664 BNIP3 False True NA 665 BNIP3L False True TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 667 DST False True Assembly of collagen fibrils and other multimeric structures;Type I hemidesmosome assembly 672 BRCA1 False True Meiotic synapsis;SUMOylation of DNA damage response and repair proteins;HDR through Single Strand Annealing (SSA);HDR through Homologous Recombination (HRR);Metalloprotease DUBs;Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA);Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Resolution of D-loop Structures through Holliday Junction Intermediates;Nonhomologous End-Joining (NHEJ);Homologous DNA Pairing and Strand Exchange;Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;TP53 Regulates Transcription of DNA Repair Genes;Regulation of TP53 Activity through Phosphorylation;G2/M DNA damage checkpoint;Transcriptional Regulation by E2F6;Meiotic recombination 673 BRAF False True Spry regulation of FGF signaling;Frs2-mediated activation;ARMS-mediated activation;Signalling to p38 via RIT and RIN;RAF activation;MAP2K and MAPK activation;Negative feedback regulation of MAPK pathway;Negative regulation of MAPK pathway;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF 678 ZFP36L2 False True NA 695 BTK False True ER-Phagosome pathway;MyD88:MAL(TIRAP) cascade initiated on plasma membrane;Regulation of actin dynamics for phagocytic cup formation;DAP12 signaling;FCERI mediated Ca+2 mobilization;FCERI mediated Ca+2 mobilization;G alpha (q) signalling events;G alpha (12/13) signalling events;MyD88 deficiency (TLR2/4);IRAK4 deficiency (TLR2/4);RHO GTPases Activate WASPs and WAVEs;G beta:gamma signalling through BTK;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 705 BYSL False True Major pathway of rRNA processing in the nucleolus and cytosol 706 TSPO False True Pregnenolone biosynthesis 708 C1QBP False True Intrinsic Pathway of Fibrin Clot Formation 710 SERPING1 False True Platelet degranulation ;Intrinsic Pathway of Fibrin Clot Formation;Regulation of Complement cascade 720 C4A False True Initial triggering of complement;Activation of C3 and C5;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation;Regulation of Complement cascade 727 C5 False True Terminal pathway of complement;Activation of C3 and C5;Peptide ligand-binding receptors;G alpha (i) signalling events;Regulation of Complement cascade 763 CA5A False True Reversible hydration of carbon dioxide 780 DDR1 False True Non-integrin membrane-ECM interactions 786 CACNG1 False True Phase 0 - rapid depolarisation;Phase 2 - plateau phase 790 CAD False True Pyrimidine biosynthesis 800 CALD1 False True Smooth Muscle Contraction 801 CALM1 False True CaMK IV-mediated phosphorylation of CREB;CaMK IV-mediated phosphorylation of CREB;Calmodulin induced events;Cam-PDE 1 activation;CaM pathway;Platelet degranulation ;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation;PKA activation;DARPP-32 events;Synthesis of IP3 and IP4 in the cytosol;Calcineurin activates NFAT;Calcineurin activates NFAT;eNOS activation;Transcriptional activation of mitochondrial biogenesis;Inactivation, recovery and regulation of the phototransduction cascade;Inactivation, recovery and regulation of the phototransduction cascade;Stimuli-sensing channels;FCERI mediated Ca+2 mobilization;FCERI mediated Ca+2 mobilization;Ca2+ pathway;Reduction of cytosolic Ca++ levels;Sodium/Calcium exchangers;Unblocking of NMDA receptors, glutamate binding and activation;CREB1 phosphorylation through the activation of Adenylate Cyclase;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;Ras activation upon Ca2+ influx through NMDA receptor;Smooth Muscle Contraction;Smooth Muscle Contraction;Activation of Ca-permeable Kainate Receptor;Uptake and function of anthrax toxins;VEGFR2 mediated vascular permeability;VEGFR2 mediated cell proliferation;Phase 0 - rapid depolarisation;Ion homeostasis;CLEC7A (Dectin-1) induces NFAT activation;CLEC7A (Dectin-1) induces NFAT activation;RHO GTPases activate IQGAPs;RHO GTPases activate PAKs;RHO GTPases activate PAKs;RAF activation;RAF/MAP kinase cascade;Signaling by moderate kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF;Glycogen breakdown (glycogenolysis);Glycogen breakdown (glycogenolysis);Protein methylation;Loss of phosphorylation of MECP2 at T308;Regulation of MECP2 expression and activity;Ion transport by P-type ATPases;Negative regulation of NMDA receptor-mediated neuronal transmission;Activation of RAC1 downstream of NMDARs;Activation of RAC1 downstream of NMDARs;Activation of AMPK downstream of NMDARs;Long-term potentiation;Long-term potentiation;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 810 CALML3 True True NA 811 CALR False True ER-Phagosome pathway;Assembly of Viral Components at the Budding Site;Scavenging by Class A Receptors;Scavenging by Class A Receptors;Scavenging by Class F Receptors;Scavenging by Class F Receptors;ATF6 (ATF6-alpha) activates chaperone genes;Calnexin/calreticulin cycle;Antigen Presentation: Folding, assembly and peptide loading of class I MHC 813 CALU False True Platelet degranulation ;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation 814 CAMK4 False True CaMK IV-mediated phosphorylation of CREB;CaMK IV-mediated phosphorylation of CREB;Transcriptional activation of mitochondrial biogenesis;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;Loss of phosphorylation of MECP2 at T308;Regulation of MECP2 expression and activity;Negative regulation of NMDA receptor-mediated neuronal transmission 815 CAMK2A False True CaMK IV-mediated phosphorylation of CREB;HSF1-dependent transactivation;Trafficking of AMPA receptors;Ca2+ pathway;Unblocking of NMDA receptors, glutamate binding and activation;Phase 0 - rapid depolarisation;Ion homeostasis;RAF activation;Signaling by moderate kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF;Interferon gamma signaling;Regulation of MECP2 expression and activity;Ion transport by P-type ATPases;Negative regulation of NMDA receptor-mediated neuronal transmission;Long-term potentiation 816 CAMK2B False True CaMK IV-mediated phosphorylation of CREB;HSF1-dependent transactivation;Trafficking of AMPA receptors;Unblocking of NMDA receptors, glutamate binding and activation;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;Phase 0 - rapid depolarisation;Ion homeostasis;RAF activation;Signaling by moderate kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF;Interferon gamma signaling;Regulation of MECP2 expression and activity;Ion transport by P-type ATPases;Negative regulation of NMDA receptor-mediated neuronal transmission;Long-term potentiation 817 CAMK2D False True CaMK IV-mediated phosphorylation of CREB;HSF1-dependent transactivation;Trafficking of AMPA receptors;Unblocking of NMDA receptors, glutamate binding and activation;Phase 0 - rapid depolarisation;Ion homeostasis;RAF activation;Signaling by moderate kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF;Interferon gamma signaling;Regulation of MECP2 expression and activity;Ion transport by P-type ATPases;Negative regulation of NMDA receptor-mediated neuronal transmission;Long-term potentiation 818 CAMK2G False True CaMK IV-mediated phosphorylation of CREB;HSF1-dependent transactivation;Trafficking of AMPA receptors;Unblocking of NMDA receptors, glutamate binding and activation;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;Phase 0 - rapid depolarisation;Ion homeostasis;RAF activation;Signaling by moderate kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF;Interferon gamma signaling;Regulation of MECP2 expression and activity;Ion transport by P-type ATPases;Negative regulation of NMDA receptor-mediated neuronal transmission;Long-term potentiation 819 CAMLG False True NA 821 CANX False True Assembly of Viral Components at the Budding Site;MHC class II antigen presentation;Interleukin-35 Signalling;Calnexin/calreticulin cycle;Interleukin-27 signaling;Antigen Presentation: Folding, assembly and peptide loading of class I MHC;Antigen Presentation: Folding, assembly and peptide loading of class I MHC 822 CAPG True True NA 823 CAPN1 True True Degradation of the extracellular matrix;Degradation of the extracellular matrix;Neutrophil degranulation;Formation of the cornified envelope;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models 824 CAPN2 False True Degradation of the extracellular matrix;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models 826 CAPNS1 False True Degradation of the extracellular matrix;Degradation of the extracellular matrix;Formation of the cornified envelope;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models 829 CAPZA1 False True MHC class II antigen presentation;HSP90 chaperone cycle for steroid hormone receptors (SHR);COPI-mediated anterograde transport;COPI-independent Golgi-to-ER retrograde traffic;Advanced glycosylation endproduct receptor signaling;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation;Factors involved in megakaryocyte development and platelet production;Factors involved in megakaryocyte development and platelet production 830 CAPZA2 False True MHC class II antigen presentation;HSP90 chaperone cycle for steroid hormone receptors (SHR);COPI-mediated anterograde transport;COPI-independent Golgi-to-ER retrograde traffic;Advanced glycosylation endproduct receptor signaling;Factors involved in megakaryocyte development and platelet production;Factors involved in megakaryocyte development and platelet production 831 CAST False True Degradation of the extracellular matrix;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models 832 CAPZB True True MHC class II antigen presentation;HSP90 chaperone cycle for steroid hormone receptors (SHR);COPI-mediated anterograde transport;COPI-independent Golgi-to-ER retrograde traffic;Factors involved in megakaryocyte development and platelet production;Factors involved in megakaryocyte development and platelet production 833 CARS False True Cytosolic tRNA aminoacylation 834 CASP1 False True NOD1/2 Signaling Pathway;Interleukin-1 processing;TP53 Regulates Transcription of Caspase Activators and Caspases;The NLRP3 inflammasome;The AIM2 inflammasome;The IPAF inflammasome;Interleukin-37 signaling 835 CASP2 False True NOD1/2 Signaling Pathway;NADE modulates death signalling;TP53 Regulates Transcription of Caspase Activators and Caspases 836 CASP3 False True Activation of caspases through apoptosome-mediated cleavage;SMAC (DIABLO) binds to IAPs ;SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ;Apoptotic cleavage of cellular proteins;SMAC, XIAP-regulated apoptotic response;Degradation of the extracellular matrix;Signaling by Hippo;NADE modulates death signalling;Activation of DNA fragmentation factor;Stimulation of the cell death response by PAK-2p34;Caspase-mediated cleavage of cytoskeletal proteins;Apoptotic cleavage of cell adhesion proteins;Caspase activation via Dependence Receptors in the absence of ligand;Caspase activation via Dependence Receptors in the absence of ligand;Other interleukin signaling 837 CASP4 False True NOD1/2 Signaling Pathway 840 CASP7 False True Activation of caspases through apoptosome-mediated cleavage;SMAC (DIABLO) binds to IAPs ;SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ;Apoptotic cleavage of cellular proteins;SMAC, XIAP-regulated apoptotic response;Caspase-mediated cleavage of cytoskeletal proteins 841 CASP8 False True Apoptotic cleavage of cellular proteins;Caspase activation via Death Receptors in the presence of ligand;NOD1/2 Signaling Pathway;TRIF-mediated programmed cell death;Caspase-mediated cleavage of cytoskeletal proteins;Regulation by c-FLIP;RIPK1-mediated regulated necrosis;CASP8 activity is inhibited;TNFR1-induced proapoptotic signaling;Regulation of TNFR1 signaling;CLEC7A/inflammasome pathway;Regulation of necroptotic cell death;Dimerization of procaspase-8;Activation, myristolyation of BID and translocation to mitochondria;Apoptotic execution phase;FasL/ CD95L signaling;TRAIL signaling;TLR3-mediated TICAM1-dependent programmed cell death;NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 843 CASP10 False True TP53 Regulates Transcription of Caspase Activators and Caspases;FasL/ CD95L signaling;TRAIL signaling;NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 847 CAT True True Detoxification of Reactive Oxygen Species;Neutrophil degranulation;Peroxisomal protein import;Peroxisomal protein import;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 857 CAV1 False True Triglyceride catabolism;eNOS activation;NOSTRIN mediated eNOS trafficking;Basigin interactions;Disassembly of the destruction complex and recruitment of AXIN to the membrane;VEGFR2 mediated vascular permeability;FOXO-mediated transcription of cell cycle genes 865 CBFB False True RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs);Transcriptional regulation by RUNX2;Transcriptional regulation by RUNX2;RUNX1 regulates estrogen receptor mediated transcription;Regulation of RUNX1 Expression and Activity;RUNX1 regulates expression of components of tight junctions;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;RUNX1 regulates transcription of genes involved in differentiation of HSCs;RUNX1 regulates transcription of genes involved in differentiation of HSCs;RUNX1 regulates transcription of genes involved in differentiation of keratinocytes;RUNX1 regulates transcription of genes involved in differentiation of keratinocytes;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known;RUNX1 regulates transcription of genes involved in BCR signaling;RUNX1 regulates transcription of genes involved in differentiation of myeloid cells;RUNX1 regulates transcription of genes involved in interleukin signaling;RUNX1 regulates transcription of genes involved in WNT signaling;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;RUNX2 regulates osteoblast differentiation;RUNX2 regulates osteoblast differentiation;RUNX2 regulates chondrocyte maturation;RUNX2 regulates bone development;RUNX2 regulates genes involved in cell migration;RUNX2 regulates genes involved in cell migration;RUNX2 regulates genes involved in differentiation of myeloid cells;Regulation of RUNX3 expression and activity;RUNX3 Regulates Immune Response and Cell Migration;RUNX3 Regulates Immune Response and Cell Migration;RUNX3 regulates RUNX1-mediated transcription;RUNX3 regulates p14-ARF;Estrogen-dependent gene expression 867 CBL False True Interleukin-6 signaling;Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants;Spry regulation of FGF signaling;Regulation of KIT signaling;EGFR downregulation;TGF-beta receptor signaling activates SMADs;Constitutive Signaling by EGFRvIII;Negative regulation of FGFR1 signaling;Negative regulation of FGFR2 signaling;Negative regulation of FGFR3 signaling;Negative regulation of FGFR4 signaling;Negative regulation of MET activity;PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;InlB-mediated entry of Listeria monocytogenes into host cell;InlB-mediated entry of Listeria monocytogenes into host cell;Regulation of signaling by CBL;Regulation of signaling by CBL 871 SERPINH1 False True Collagen biosynthesis and modifying enzymes 875 CBS False True Cysteine formation from homocysteine;Metabolism of ingested SeMet, Sec, MeSec into H2Se 890 CCNA2 False True Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1;G0 and Early G1;Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Regulation of APC/C activators between G1/S and early anaphase;SCF(Skp2)-mediated degradation of p27/p21;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;Ub-specific processing proteases;Processing of DNA double-strand break ends;TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest;Regulation of TP53 Activity through Phosphorylation;Regulation of TP53 Degradation;G2 Phase;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Cyclin A/B1/B2 associated events during G2/M transition;Cyclin A/B1/B2 associated events during G2/M transition;p53-Dependent G1 DNA Damage Response;Cyclin A:Cdk2-associated events at S phase entry 891 CCNB1 False True E2F-enabled inhibition of pre-replication complex formation;Polo-like kinase mediated events;Golgi Cisternae Pericentriolar Stack Reorganization;APC/C:Cdc20 mediated degradation of Cyclin B;Regulation of APC/C activators between G1/S and early anaphase;Phosphorylation of the APC/C;Phosphorylation of Emi1;Condensation of Prophase Chromosomes;MASTL Facilitates Mitotic Progression;Resolution of Sister Chromatid Cohesion;Condensation of Prometaphase Chromosomes;Regulation of PLK1 Activity at G2/M Transition;Activation of NIMA Kinases NEK9, NEK6, NEK7;Nuclear Pore Complex (NPC) Disassembly;Depolymerisation of the Nuclear Lamina;TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest;Mitotic Prophase;Cyclin A/B1/B2 associated events during G2/M transition;G2/M DNA replication checkpoint;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;The role of GTSE1 in G2/M progression after G2 checkpoint;Transcriptional regulation by RUNX2 892 CCNC False True PPARA activates gene expression;NOTCH1 Intracellular Domain Regulates Transcription;Generic Transcription Pathway;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Transcriptional regulation of white adipocyte differentiation;Transcriptional regulation of white adipocyte differentiation 900 CCNG1 False True Regulation of TP53 Degradation 908 CCT6A False True Prefoldin mediated transfer of substrate to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Folding of actin by CCT/TriC;Association of TriC/CCT with target proteins during biosynthesis;Association of TriC/CCT with target proteins during biosynthesis;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 919 CD247 False True Nef and signal transduction;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Downstream TCR signaling;Phosphorylation of CD3 and TCR zeta chains;Translocation of ZAP-70 to Immunological synapse;Generation of second messenger molecules;FCGR activation;FCGR activation;Regulation of actin dynamics for phagocytic cup formation;Role of phospholipids in phagocytosis;PD-1 signaling 929 CD14 False True ER-Phagosome pathway;Caspase activation via Death Receptors in the presence of ligand;Toll Like Receptor 4 (TLR4) Cascade;Transfer of LPS from LBP carrier to CD14;MyD88:MAL(TIRAP) cascade initiated on plasma membrane;MyD88-independent TLR4 cascade ;Toll Like Receptor TLR1:TLR2 Cascade;Toll Like Receptor TLR6:TLR2 Cascade;TRIF-mediated programmed cell death;MyD88 deficiency (TLR2/4);IRAK4 deficiency (TLR2/4);Regulation of TLR by endogenous ligand;Neutrophil degranulation;Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon;IKK complex recruitment mediated by RIP1;TRAF6-mediated induction of TAK1 complex within TLR4 complex;IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 931 MS4A1 False True NA 950 SCARB2 False True Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis 956 ENTPD3 False True Phosphate bond hydrolysis by NTPDase proteins 960 CD44 False True Degradation of the extracellular matrix;Cell surface interactions at the vascular wall;Integrin cell surface interactions;Hyaluronan uptake and degradation;Neutrophil degranulation;Interferon gamma signaling 971 CD72 False True Other semaphorin interactions 975 CD81 False True Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Regulation of Complement cascade 983 CDK1 False True MAPK3 (ERK1) activation;E2F-enabled inhibition of pre-replication complex formation;Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1;Golgi Cisternae Pericentriolar Stack Reorganization;Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes;APC/C:Cdc20 mediated degradation of Cyclin B;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Regulation of APC/C activators between G1/S and early anaphase;Phosphorylation of the APC/C;Phosphorylation of Emi1;Condensation of Prophase Chromosomes;MASTL Facilitates Mitotic Progression;Resolution of Sister Chromatid Cohesion;Condensation of Prometaphase Chromosomes;Regulation of PLK1 Activity at G2/M Transition;Activation of NIMA Kinases NEK9, NEK6, NEK7;Nuclear Pore Complex (NPC) Disassembly;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Depolymerisation of the Nuclear Lamina;Activation of E2F1 target genes at G1/S;Anchoring of the basal body to the plasma membrane;MAPK6/MAPK4 signaling;Ovarian tumor domain proteases;TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest;Regulation of TP53 Degradation;Mitotic Prophase;Cyclin A/B1/B2 associated events during G2/M transition;Cyclin A/B1/B2 associated events during G2/M transition;G2/M DNA replication checkpoint;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;The role of GTSE1 in G2/M progression after G2 checkpoint;AURKA Activation by TPX2;Transcriptional regulation by RUNX2 984 CDK11B False True Recruitment of mitotic centrosome proteins and complexes 988 CDC5L False True mRNA Splicing - Major Pathway 989 SEPT7 False True MAPK6/MAPK4 signaling 990 CDC6 False True Transcription of E2F targets under negative control by DREAM complex;Activation of ATR in response to replication stress;Activation of E2F1 target genes at G1/S;CDC6 association with the ORC:origin complex;CDT1 association with the CDC6:ORC:origin complex;Assembly of the pre-replicative complex;Orc1 removal from chromatin;Activation of the pre-replicative complex;CDK-mediated phosphorylation and removal of Cdc6 993 CDC25A False True Transcription of E2F targets under negative control by DREAM complex;Polo-like kinase mediated events;Activation of ATR in response to replication stress;Ub-specific processing proteases;Cyclin E associated events during G1/S transition ;Cyclin A/B1/B2 associated events during G2/M transition;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Cyclin A:Cdk2-associated events at S phase entry;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models 994 CDC25B False True Cyclin A/B1/B2 associated events during G2/M transition;Cyclin A:Cdk2-associated events at S phase entry;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models 995 CDC25C False True Polo-like kinase mediated events;Activation of ATR in response to replication stress;RHO GTPases activate PKNs;TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest;TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain;Cyclin A/B1/B2 associated events during G2/M transition;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models 998 CDC42 False True GPVI-mediated activation cascade;EGFR downregulation;Rho GTPase cycle;Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;CDO in myogenesis;CDO in myogenesis;CD28 dependent Vav1 pathway;EPHB-mediated forward signaling;EPHB-mediated forward signaling;DCC mediated attractive signaling;Inactivation of CDC42 and RAC1;VEGFA-VEGFR2 Pathway;RHO GTPases activate KTN1;RHO GTPases activate IQGAPs;RHO GTPases activate PAKs;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate Formins;RHO GTPases Activate Formins;MAPK6/MAPK4 signaling;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation;G beta:gamma signalling through CDC42;Factors involved in megakaryocyte development and platelet production 999 CDH1 False True Degradation of the extracellular matrix;Degradation of the extracellular matrix;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Integrin cell surface interactions;Apoptotic cleavage of cell adhesion proteins;Adherens junctions interactions;RHO GTPases activate IQGAPs;InlA-mediated entry of Listeria monocytogenes into host cells 1003 CDH5 False True Adherens junctions interactions;VEGFR2 mediated vascular permeability 1017 CDK2 False True G0 and Early G1;Activation of ATR in response to replication stress;Regulation of APC/C activators between G1/S and early anaphase;SCF(Skp2)-mediated degradation of p27/p21;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;Processing of DNA double-strand break ends;TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest;Regulation of TP53 Activity through Phosphorylation;Regulation of TP53 Degradation;G2 Phase;Orc1 removal from chromatin;Activation of the pre-replicative complex;CDK-mediated phosphorylation and removal of Cdc6;Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes;Cyclin E associated events during G1/S transition ;Cyclin A/B1/B2 associated events during G2/M transition;p53-Dependent G1 DNA Damage Response;Cyclin A:Cdk2-associated events at S phase entry;PTK6 Regulates Cell Cycle;Meiotic recombination;Factors involved in megakaryocyte development and platelet production 1018 CDK3 False True NA 1019 CDK4 False True SCF(Skp2)-mediated degradation of p27/p21;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);Oncogene Induced Senescence;RMTs methylate histone arginines;Transcriptional regulation of white adipocyte differentiation;Ubiquitin-dependent degradation of Cyclin D1;Ubiquitin-dependent degradation of Cyclin D1;Cyclin D associated events in G1;PTK6 Regulates Cell Cycle;Transcriptional regulation by RUNX2;Meiotic recombination 1021 CDK6 False True Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);Oncogene Induced Senescence;Cyclin D associated events in G1;Regulation of RUNX1 Expression and Activity 1022 CDK7 False True Formation of RNA Pol II elongation complex ;Formation of the Early Elongation Complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of the HIV-1 Early Elongation Complex;RNA Pol II CTD phosphorylation and interaction with CE during HIV infection;HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;Formation of HIV-1 elongation complex containing HIV-1 Tat;Tat-mediated elongation of the HIV-1 transcript;NoRC negatively regulates rRNA expression;Formation of Incision Complex in GG-NER;RNA Polymerase II Pre-transcription Events;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;TP53 Regulates Transcription of DNA Repair Genes;RNA polymerase II transcribes snRNA genes;RNA polymerase II transcribes snRNA genes;Cyclin E associated events during G1/S transition ;Cyclin D associated events in G1;Cyclin A/B1/B2 associated events during G2/M transition;Cyclin A:Cdk2-associated events at S phase entry;mRNA Capping;RNA Polymerase I Transcription Initiation;RNA Polymerase I Promoter Escape;RNA Polymerase II Promoter Escape;RNA Polymerase I Chain Elongation;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase I Transcription Termination;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Elongation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Pol II CTD phosphorylation and interaction with CE;RUNX1 regulates transcription of genes involved in differentiation of HSCs 1025 CDK9 False True Formation of RNA Pol II elongation complex ;Formation of HIV elongation complex in the absence of HIV Tat;Formation of HIV-1 elongation complex containing HIV-1 Tat;Formation of HIV-1 elongation complex containing HIV-1 Tat;Pausing and recovery of Tat-mediated HIV elongation;Tat-mediated HIV elongation arrest and recovery;Tat-mediated elongation of the HIV-1 transcript;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;Interactions of Tat with host cellular proteins;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;RNA Polymerase II Pre-transcription Events;TP53 Regulates Transcription of DNA Repair Genes;RNA polymerase II transcribes snRNA genes;RNA polymerase II transcribes snRNA genes;RNA Polymerase II Transcription Elongation;Estrogen-dependent gene expression 1026 CDKN1A False True SCF(Skp2)-mediated degradation of p27/p21;AKT phosphorylates targets in the cytosol;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;Constitutive Signaling by AKT1 E17K in Cancer;Interleukin-4 and Interleukin-13 signaling;TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest;Cyclin E associated events during G1/S transition ;Cyclin D associated events in G1;p53-Dependent G1 DNA Damage Response;Cyclin A:Cdk2-associated events at S phase entry;Transcriptional activation of cell cycle inhibitor p21 ;The role of GTSE1 in G2/M progression after G2 checkpoint;TFAP2 (AP-2) family regulates transcription of cell cycle factors;Transcriptional regulation by RUNX2;RUNX3 regulates CDKN1A transcription;FOXO-mediated transcription of cell cycle genes 1027 CDKN1B False True SCF(Skp2)-mediated degradation of p27/p21;AKT phosphorylates targets in the cytosol;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;RHO GTPases activate CIT;Constitutive Signaling by AKT1 E17K in Cancer;TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest;Cyclin E associated events during G1/S transition ;Cyclin D associated events in G1;p53-Dependent G1 DNA Damage Response;Cyclin A:Cdk2-associated events at S phase entry;PTK6 Regulates Cell Cycle;FOXO-mediated transcription of cell cycle genes 1029 CDKN2A False True Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);Oncogene Induced Senescence;SUMOylation of DNA damage response and repair proteins;SUMOylation of transcription factors;Regulation of TP53 Degradation;Cyclin D associated events in G1;Stabilization of p53;Regulation of RUNX3 expression and activity 1039 CDR2 False True NA 1043 NA False True Post-translational modification: synthesis of GPI-anchored proteins 1053 CEBPE False True NA 1062 CENPE False True Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;COPI-dependent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;Kinesins 1070 CETN3 False True NA 1072 CFL1 False True Platelet degranulation ;Regulation of actin dynamics for phagocytic cup formation;EPHB-mediated forward signaling;Sema3A PAK dependent Axon repulsion;RHO GTPases Activate ROCKs;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 1073 CFL2 False True NA 1075 CTSC False True COPII-mediated vesicle transport;MHC class II antigen presentation;Cargo concentration in the ER;Neutrophil degranulation 1080 CFTR False True ABC-family proteins mediated transport;RHO GTPases regulate CFTR trafficking;Defective CFTR causes cystic fibrosis;Ub-specific processing proteases;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis 1102 RCBTB2 False True NA 1104 RCC1 False True Rev-mediated nuclear export of HIV RNA;Nuclear import of Rev protein 1107 CHD3 False True HDACs deacetylate histones;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;SUMOylation of chromatin organization proteins;Regulation of TP53 Activity through Acetylation;RNA Polymerase I Transcription Initiation;Regulation of PTEN gene transcription;Regulation of PTEN gene transcription 1111 CHEK1 False True Signaling by SCF-KIT;Activation of ATR in response to replication stress;Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;TP53 Regulates Transcription of DNA Repair Genes;Regulation of TP53 Activity through Phosphorylation;G2/M DNA damage checkpoint;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;Transcriptional Regulation by E2F6 1120 NA False True Synthesis of PC;Synthesis of PE 1130 LYST False True NA 1147 CHUK False True Activation of NF-kappaB in B cells;Activation of NF-kappaB in B cells;ER-Phagosome pathway;NOD1/2 Signaling Pathway;TICAM1, RIP1-mediated IKK complex recruitment ;RIP-mediated NFkB activation via ZBP1;AKT phosphorylates targets in the cytosol;Downstream TCR signaling;FCERI mediated NF-kB activation;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;IKBKB deficiency causes SCID;IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR);IkBA variant leads to EDA-ID;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Constitutive Signaling by AKT1 E17K in Cancer;NIK-->noncanonical NF-kB signaling;MAP3K8 (TPL2)-dependent MAPK1/3 activation;Interleukin-1 signaling;TRAF6 mediated NF-kB activation;NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10;IRAK1 recruits IKK complex;IKK complex recruitment mediated by RIP1;IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 1152 CKB False True Creatine metabolism 1155 TBCB False True Post-chaperonin tubulin folding pathway 1159 CKMT1B False True Creatine metabolism 1160 CKMT2 False True Creatine metabolism 1173 AP2M1 False True Nef mediated downregulation of CD28 cell surface expression;Nef Mediated CD4 Down-regulation;Retrograde neurotrophin signalling;Retrograde neurotrophin signalling;Nef Mediated CD8 Down-regulation;Gap junction degradation;Formation of annular gap junctions;MHC class II antigen presentation;EPH-ephrin mediated repulsion of cells;Trafficking of GluR2-containing AMPA receptors;Recycling pathway of L1;Recycling pathway of L1;WNT5A-dependent internalization of FZD4;WNT5A-dependent internalization of FZD2, FZD5 and ROR2;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;VLDLR internalisation and degradation;LDL clearance 1182 CLCN3 False True Stimuli-sensing channels 1186 NA False True Stimuli-sensing channels 1196 CLK2 False True NA 1198 CLK3 False True NA 1207 CLNS1A False True snRNP Assembly 1211 CLTA False True Entry of Influenza Virion into Host Cell via Endocytosis;Retrograde neurotrophin signalling;Retrograde neurotrophin signalling;Gap junction degradation;Formation of annular gap junctions;MHC class II antigen presentation;EPH-ephrin mediated repulsion of cells;Lysosome Vesicle Biogenesis;Golgi Associated Vesicle Biogenesis;Recycling pathway of L1;Recycling pathway of L1;WNT5A-dependent internalization of FZD4;WNT5A-dependent internalization of FZD2, FZD5 and ROR2;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;VLDLR internalisation and degradation;LDL clearance 1212 CLTB False True Gap junction degradation;Formation of annular gap junctions;EPH-ephrin mediated repulsion of cells;Lysosome Vesicle Biogenesis;WNT5A-dependent internalization of FZD4;WNT5A-dependent internalization of FZD2, FZD5 and ROR2;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis 1213 CLTC False True Entry of Influenza Virion into Host Cell via Endocytosis;Retrograde neurotrophin signalling;Retrograde neurotrophin signalling;Gap junction degradation;Formation of annular gap junctions;MHC class II antigen presentation;EPH-ephrin mediated repulsion of cells;Lysosome Vesicle Biogenesis;Golgi Associated Vesicle Biogenesis;Recycling pathway of L1;Recycling pathway of L1;WNT5A-dependent internalization of FZD4;WNT5A-dependent internalization of FZD2, FZD5 and ROR2;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;VLDLR internalisation and degradation;LDL clearance 1244 ABCC2 False True ABC-family proteins mediated transport;Defective ABCC2 causes Dubin-Johnson syndrome 1277 COL1A1 False True GPVI-mediated activation cascade;Collagen degradation;Collagen degradation;Extracellular matrix organization;Collagen biosynthesis and modifying enzymes;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Assembly of collagen fibrils and other multimeric structures;Cell surface interactions at the vascular wall;Integrin cell surface interactions;Integrin cell surface interactions;Anchoring fibril formation;Crosslinking of collagen fibrils;Syndecan interactions;Non-integrin membrane-ECM interactions;ECM proteoglycans;ECM proteoglycans;Scavenging by Class A Receptors;GP1b-IX-V activation signalling;Platelet Adhesion to exposed collagen;Platelet Adhesion to exposed collagen;Platelet Aggregation (Plug Formation);MET activates PTK2 signaling;RUNX2 regulates osteoblast differentiation;Collagen chain trimerization 1278 COL1A2 False True GPVI-mediated activation cascade;Collagen degradation;Collagen degradation;Extracellular matrix organization;Collagen biosynthesis and modifying enzymes;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Assembly of collagen fibrils and other multimeric structures;Cell surface interactions at the vascular wall;Integrin cell surface interactions;Integrin cell surface interactions;Anchoring fibril formation;Crosslinking of collagen fibrils;Syndecan interactions;Non-integrin membrane-ECM interactions;ECM proteoglycans;ECM proteoglycans;Scavenging by Class A Receptors;GP1b-IX-V activation signalling;Interleukin-4 and Interleukin-13 signaling;Platelet Adhesion to exposed collagen;Platelet Adhesion to exposed collagen;Platelet Aggregation (Plug Formation);MET activates PTK2 signaling;Collagen chain trimerization 1296 COL8A2 False True Collagen degradation;Collagen degradation;Collagen biosynthesis and modifying enzymes;Assembly of collagen fibrils and other multimeric structures;Integrin cell surface interactions;Collagen chain trimerization 1314 COPA False True COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic 1315 COPB1 False True Neutrophil degranulation;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic 1326 MAP3K8 False True CD28 dependent PI3K/Akt signaling;MAP3K8 (TPL2)-dependent MAPK1/3 activation;MAP3K8 (TPL2)-dependent MAPK1/3 activation 1345 COX6C False True TP53 Regulates Metabolic Genes;Respiratory electron transport 1368 CPM False True Post-translational modification: synthesis of GPI-anchored proteins 1373 CPS1 False True Urea cycle 1374 CPT1A False True RORA activates gene expression;PPARA activates gene expression;Import of palmitoyl-CoA into the mitochondrial matrix;Signaling by Retinoic Acid 1387 CREBBP False True Regulation of gene expression by Hypoxia-inducible Factor;RORA activates gene expression;BMAL1:CLOCK,NPAS2 activates circadian gene expression;Pre-NOTCH Transcription and Translation;Pre-NOTCH Transcription and Translation;PPARA activates gene expression;PPARA activates gene expression;Formation of the beta-catenin:TCF transactivating complex;Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells;NOTCH1 Intracellular Domain Regulates Transcription;NOTCH1 Intracellular Domain Regulates Transcription;Transcriptional activation of mitochondrial biogenesis;Activation of gene expression by SREBF (SREBP);Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production;HATs acetylate histones;Attenuation phase;Notch-HLH transcription pathway;Transcriptional regulation of white adipocyte differentiation;Transcriptional regulation of white adipocyte differentiation;SUMOylation of transcription cofactors;Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha);Circadian Clock;Activation of anterior HOX genes in hindbrain development during early embryogenesis;CD209 (DC-SIGN) signaling;TP53 Regulates Transcription of Genes Involved in Cytochrome C Release;Activation of the TFAP2 (AP-2) family of transcription factors;RUNX1 regulates transcription of genes involved in differentiation of myeloid cells;RUNX3 regulates NOTCH signaling;RUNX3 regulates NOTCH signaling;NOTCH3 Intracellular Domain Regulates Transcription;NOTCH3 Intracellular Domain Regulates Transcription;NOTCH4 Intracellular Domain Regulates Transcription;Estrogen-dependent gene expression;TRAF3-dependent IRF activation pathway;TRAF6 mediated IRF7 activation;FOXO-mediated transcription of cell death genes;Regulation of FOXO transcriptional activity by acetylation;Regulation of FOXO transcriptional activity by acetylation 1396 CRIP1 False True NA 1398 CRK False True ARMS-mediated activation;ARMS-mediated activation;Downstream signal transduction;Regulation of actin dynamics for phagocytic cup formation;p130Cas linkage to MAPK signaling for integrins;VEGFA-VEGFR2 Pathway;PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases;MET activates RAP1 and RAC1;MET receptor recycling;Regulation of signaling by CBL 1399 CRKL False True Frs2-mediated activation;Frs2-mediated activation;Downstream signal transduction;MET activates RAP1 and RAC1;MET receptor recycling;Erythropoietin activates RAS;Erythropoietin activates RAS;Regulation of signaling by CBL 1408 CRY2 False True Circadian Clock 1409 CRYAA False True NA 1410 CRYAB False True HSF1-dependent transactivation 1415 CRYBB2 False True NA 1429 CRYZ False True NA 1431 CS False True Mitochondrial protein import;Citric acid cycle (TCA cycle) 1432 MAPK14 False True NOD1/2 Signaling Pathway;p38MAPK events;p38MAPK events;ERK/MAPK targets;Activation of PPARGC1A (PGC-1alpha) by phosphorylation;Oxidative Stress Induced Senescence;CDO in myogenesis;CDO in myogenesis;DSCAM interactions;ADP signalling through P2Y purinoceptor 1;Platelet sensitization by LDL;VEGFA-VEGFR2 Pathway;activated TAK1 mediates p38 MAPK activation;Activation of the AP-1 family of transcription factors;KSRP (KHSRP) binds and destabilizes mRNA;RHO GTPases Activate NADPH Oxidases;Neutrophil degranulation;Regulation of TP53 Activity through Phosphorylation 1434 CSE1L False True NA 1436 CSF1R False True Other interleukin signaling 1452 CSNK1A1 False True Degradation of beta-catenin by the destruction complex;Beta-catenin phosphorylation cascade;Disassembly of the destruction complex and recruitment of AXIN to the membrane;Disassembly of the destruction complex and recruitment of AXIN to the membrane;Misspliced GSK3beta mutants stabilize beta-catenin;S33 mutants of beta-catenin aren't phosphorylated;S37 mutants of beta-catenin aren't phosphorylated;S45 mutants of beta-catenin aren't phosphorylated;T41 mutants of beta-catenin aren't phosphorylated;APC truncation mutants have impaired AXIN binding;AXIN missense mutants destabilize the destruction complex;Truncations of AMER1 destabilize the destruction complex;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Activation of SMO;Activation of SMO 1453 CSNK1D False True COPII-mediated vesicle transport;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Circadian Clock;Anchoring of the basal body to the plasma membrane;Major pathway of rRNA processing in the nucleolus and cytosol;AURKA Activation by TPX2 1457 CSNK2A1 False True Synthesis of PC;WNT mediated activation of DVL;Condensation of Prometaphase Chromosomes;Signal transduction by L1;Regulation of TP53 Activity through Phosphorylation;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding;Receptor Mediated Mitophagy;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known;Regulation of PTEN stability and activity 1459 CSNK2A2 False True Synthesis of PC;WNT mediated activation of DVL;Condensation of Prometaphase Chromosomes;Signal transduction by L1;Regulation of TP53 Activity through Phosphorylation;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding;Receptor Mediated Mitophagy;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known;Regulation of PTEN stability and activity 1465 CSRP1 False True MTF1 activates gene expression 1469 CST1 True True NA 1470 CST2 True True NA 1471 NA False True Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Neutrophil degranulation;Post-translational protein phosphorylation;Amyloid fiber formation 1472 CST4 True True NA 1474 NA True False NA 1475 CSTA True True Formation of the cornified envelope 1476 CSTB True True Neutrophil degranulation 1479 CSTF3 False True Cleavage of Growing Transcript in the Termination Region ;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Processing of Intronless Pre-mRNAs 1487 CTBP1 False True Deactivation of the beta-catenin transactivating complex;SUMOylation of transcription cofactors;Repression of WNT target genes;TCF7L2 mutants don't bind CTBP 1488 CTBP2 False True Repression of WNT target genes;TCF7L2 mutants don't bind CTBP 1495 CTNNA1 False True CDO in myogenesis;CDO in myogenesis;Adherens junctions interactions;VEGFR2 mediated vascular permeability;RHO GTPases activate IQGAPs 1499 CTNNB1 False True Degradation of beta-catenin by the destruction complex;Beta-catenin phosphorylation cascade;TCF dependent signaling in response to WNT;Formation of the beta-catenin:TCF transactivating complex;Formation of the beta-catenin:TCF transactivating complex;LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production;Apoptotic cleavage of cell adhesion proteins;CDO in myogenesis;CDO in myogenesis;Deactivation of the beta-catenin transactivating complex;Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1);Ca2+ pathway;Adherens junctions interactions;Binding of TCF/LEF:CTNNB1 to target gene promoters;Disassembly of the destruction complex and recruitment of AXIN to the membrane;Disassembly of the destruction complex and recruitment of AXIN to the membrane;VEGFR2 mediated vascular permeability;Misspliced GSK3beta mutants stabilize beta-catenin;S33 mutants of beta-catenin aren't phosphorylated;S37 mutants of beta-catenin aren't phosphorylated;S45 mutants of beta-catenin aren't phosphorylated;T41 mutants of beta-catenin aren't phosphorylated;RHO GTPases activate IQGAPs;InlA-mediated entry of Listeria monocytogenes into host cells;RUNX3 regulates WNT signaling 1500 CTNND1 False True Adherens junctions interactions;VEGFR2 mediated vascular permeability;InlA-mediated entry of Listeria monocytogenes into host cells 1503 CTPS1 False True Interconversion of nucleotide di- and triphosphates 1508 CTSB True True Collagen degradation;Trafficking and processing of endosomal TLR;Assembly of collagen fibrils and other multimeric structures;MHC class II antigen presentation;Neutrophil degranulation 1509 CTSD True True Collagen degradation;Metabolism of Angiotensinogen to Angiotensins;MHC class II antigen presentation;Neutrophil degranulation;Estrogen-dependent gene expression 1512 NA False True MHC class II antigen presentation;Surfactant metabolism;Neutrophil degranulation 1513 CTSK False True Collagen degradation;Degradation of the extracellular matrix;Activation of Matrix Metalloproteinases;Trafficking and processing of endosomal TLR;MHC class II antigen presentation;RUNX1 regulates transcription of genes involved in differentiation of keratinocytes 1514 CTSL False True Endosomal/Vacuolar pathway;Collagen degradation;Degradation of the extracellular matrix;Trafficking and processing of endosomal TLR;Assembly of collagen fibrils and other multimeric structures;MHC class II antigen presentation;RUNX1 regulates transcription of genes involved in differentiation of keratinocytes 1515 CTSV True True Endosomal/Vacuolar pathway;Degradation of the extracellular matrix;Activation of Matrix Metalloproteinases;Trafficking and processing of endosomal TLR;Assembly of collagen fibrils and other multimeric structures;MHC class II antigen presentation;RUNX1 regulates transcription of genes involved in differentiation of keratinocytes 1520 NA False True Endosomal/Vacuolar pathway;Degradation of the extracellular matrix;Degradation of the extracellular matrix;Trafficking and processing of endosomal TLR;Assembly of collagen fibrils and other multimeric structures;MHC class II antigen presentation;Neutrophil degranulation 1523 CUX1 False True Signaling by cytosolic FGFR1 fusion mutants;Signaling by FGFR1 in disease;Intra-Golgi traffic 1534 CYB561 False True NA 1537 CYC1 False True Mitochondrial protein import;Respiratory electron transport 1601 DAB2 False True Gap junction degradation;Formation of annular gap junctions;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis 1605 DAG1 False True Non-integrin membrane-ECM interactions;ECM proteoglycans;ECM proteoglycans;Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3;Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2;Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1;O-linked glycosylation;Regulation of expression of SLITs and ROBOs 1608 NA False True Effects of PIP2 hydrolysis 1613 DAPK3 False True Caspase activation via Dependence Receptors in the absence of ligand 1615 DARS False True SeMet incorporation into proteins;Cytosolic tRNA aminoacylation 1616 DAXX False True SUMOylation of transcription cofactors;Regulation of TP53 Degradation 1622 DBI False True Mitochondrial Fatty Acid Beta-Oxidation 1627 DBN1 False True NA 1630 DCC False True Netrin-1 signaling;Netrin-1 signaling;DSCAM interactions;DCC mediated attractive signaling;DCC mediated attractive signaling;Netrin mediated repulsion signals;Caspase activation via Dependence Receptors in the absence of ligand;Role of second messengers in netrin-1 signaling;Regulation of commissural axon pathfinding by SLIT and ROBO 1632 ECI1 False True mitochondrial fatty acid beta-oxidation of unsaturated fatty acids 1636 ACE False True Metabolism of Angiotensinogen to Angiotensins 1639 DCTN1 False True MHC class II antigen presentation;Regulation of PLK1 Activity at G2/M Transition;HSP90 chaperone cycle for steroid hormone receptors (SHR);Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;XBP1(S) activates chaperone genes;Anchoring of the basal body to the plasma membrane;COPI-mediated anterograde transport;COPI-independent Golgi-to-ER retrograde traffic;AURKA Activation by TPX2 1642 DDB1 False True Recognition of DNA damage by PCNA-containing replication complex;DNA Damage Recognition in GG-NER;Formation of Incision Complex in GG-NER;Dual Incision in GG-NER;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Neddylation 1643 DDB2 False True Ub-specific processing proteases;DNA Damage Recognition in GG-NER;Formation of Incision Complex in GG-NER;Dual Incision in GG-NER;TP53 Regulates Transcription of DNA Repair Genes;Neddylation 1646 AKR1C2 False True Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol;Synthesis of bile acids and bile salts via 24-hydroxycholesterol;Synthesis of bile acids and bile salts via 27-hydroxycholesterol 1649 DDIT3 False True ATF4 activates genes;ATF6 (ATF6-alpha) activates chaperone genes;FOXO-mediated transcription of cell death genes;FOXO-mediated transcription of cell death genes 1650 DDOST False True SRP-dependent cotranslational protein targeting to membrane;Asparagine N-linked glycosylation;Neutrophil degranulation;Advanced glycosylation endproduct receptor signaling 1653 DDX1 False True tRNA processing in the nucleus 1654 DDX3X False True Neutrophil degranulation 1655 DDX5 False True SUMOylation of transcription cofactors;mRNA Splicing - Major Pathway;Estrogen-dependent gene expression 1659 DHX8 False True NA 1660 DHX9 False True RIP-mediated NFkB activation via ZBP1;DEx/H-box helicases activate type I IFN and inflammatory cytokines production ;mRNA Splicing - Major Pathway 1665 DHX15 False True mRNA Splicing - Major Pathway 1668 NA True False Defensins;Alpha-defensins 1674 DES False True Striated Muscle Contraction 1675 NA False True Platelet degranulation ;Alternative complement activation;Neutrophil degranulation 1676 DFFA False True Activation of DNA fragmentation factor 1727 CYB5R3 False True Vitamin C (ascorbate) metabolism;Phase I - Functionalization of compounds;Neutrophil degranulation 1736 DKC1 False True Telomere Extension By Telomerase;rRNA modification in the nucleus and cytosol 1737 DLAT False True Regulation of pyruvate dehydrogenase (PDH) complex;Glyoxylate metabolism and glycine degradation;Signaling by Retinoic Acid;Pyruvate metabolism 1743 DLST False True Glyoxylate metabolism and glycine degradation;Lysine catabolism;Citric acid cycle (TCA cycle) 1750 NA False True Regulation of RUNX2 expression and activity 1755 DMBT1 True True Surfactant metabolism 1756 DMD False True Non-integrin membrane-ECM interactions;Striated Muscle Contraction 1760 DMPK False True Ion homeostasis 1778 DYNC1H1 False True Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;Regulation of PLK1 Activity at G2/M Transition;HSP90 chaperone cycle for steroid hormone receptors (SHR);Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;RHO GTPases Activate Formins;Neutrophil degranulation;COPI-mediated anterograde transport;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;AURKA Activation by TPX2 1785 DNM2 False True Toll Like Receptor 4 (TLR4) Cascade;Retrograde neurotrophin signalling;Gap junction degradation;Formation of annular gap junctions;NOSTRIN mediated eNOS trafficking;MHC class II antigen presentation;Lysosome Vesicle Biogenesis;Golgi Associated Vesicle Biogenesis;Recycling pathway of L1;Clathrin-mediated endocytosis 1801 DPH1 False True Synthesis of diphthamide-EEF2 1806 DPYD False True Pyrimidine catabolism 1808 DPYSL2 False True CRMPs in Sema3A signaling;Recycling pathway of L1 1823 DSC1 False True Neutrophil degranulation;Keratinization;Formation of the cornified envelope 1825 DSC3 True True Keratinization;Formation of the cornified envelope 1828 DSG1 True True Apoptotic cleavage of cell adhesion proteins;Neutrophil degranulation;Keratinization;Formation of the cornified envelope 1829 DSG2 False True Apoptotic cleavage of cell adhesion proteins;Keratinization;Formation of the cornified envelope 1832 DSP True True Apoptotic cleavage of cell adhesion proteins;Neutrophil degranulation;Keratinization;Formation of the cornified envelope 1838 DTNB False True NA 1854 DUT False True Interconversion of nucleotide di- and triphosphates 1857 DVL3 False True TCF dependent signaling in response to WNT;WNT mediated activation of DVL;PCP/CE pathway;PCP/CE pathway;Degradation of DVL;Disassembly of the destruction complex and recruitment of AXIN to the membrane;Disassembly of the destruction complex and recruitment of AXIN to the membrane;Negative regulation of TCF-dependent signaling by DVL-interacting proteins;RHO GTPases Activate Formins 1859 DYRK1A False True G0 and Early G1 1861 TOR1A False True Cargo recognition for clathrin-mediated endocytosis 1874 E2F4 False True Transcription of E2F targets under negative control by DREAM complex;Transcription of E2F targets under negative control by DREAM complex;Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1;G0 and Early G1;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;Activation of E2F1 target genes at G1/S;Activation of E2F1 target genes at G1/S;TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest;Cyclin E associated events during G1/S transition ;Cyclin D associated events in G1;Cyclin A:Cdk2-associated events at S phase entry 1890 TYMP True True Pyrimidine salvage;Pyrimidine catabolism 1891 ECH1 False True Peroxisomal protein import;Peroxisomal protein import 1892 ECHS1 False True Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA;Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA;Beta oxidation of octanoyl-CoA to hexanoyl-CoA;Beta oxidation of hexanoyl-CoA to butanoyl-CoA;Beta oxidation of butanoyl-CoA to acetyl-CoA 1902 LPAR1 False True G alpha (q) signalling events;G alpha (i) signalling events;Lysosphingolipid and LPA receptors 1915 EEF1A1 False True Eukaryotic Translation Elongation;Eukaryotic Translation Elongation;Peptide chain elongation;HSF1 activation;Neutrophil degranulation;Protein methylation 1917 EEF1A2 False True Eukaryotic Translation Elongation 1933 EEF1B2 False True Eukaryotic Translation Elongation 1936 EEF1D False True Eukaryotic Translation Elongation 1937 EEF1G True True Eukaryotic Translation Elongation 1938 EEF2 True True Peptide chain elongation;Peptide chain elongation;Uptake and function of diphtheria toxin;Synthesis of diphthamide-EEF2;Synthesis of diphthamide-EEF2;Neutrophil degranulation;Protein methylation 1956 EGFR False True Signaling by ERBB2;Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants;Signaling by ERBB4;SHC1 events in ERBB2 signaling;SHC1 events in ERBB2 signaling;PLCG1 events in ERBB2 signaling;PIP3 activates AKT signaling;Signaling by EGFR;GRB2 events in EGFR signaling;GAB1 signalosome;SHC1 events in EGFR signaling;EGFR downregulation;GRB2 events in ERBB2 signaling;PI3K events in ERBB2 signaling;EGFR interacts with phospholipase C-gamma;EGFR Transactivation by Gastrin;Constitutive Signaling by Aberrant PI3K in Cancer;Signal transduction by L1;Constitutive Signaling by EGFRvIII;Inhibition of Signaling by Overexpressed EGFR;RAF/MAP kinase cascade;ERBB2 Regulates Cell Motility;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;ERBB2 Activates PTK6 Signaling;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;PTK6 promotes HIF1A stabilization;Downregulation of ERBB2 signaling;TFAP2 (AP-2) family regulates transcription of growth factors and their receptors;NOTCH3 Activation and Transmission of Signal to the Nucleus 1958 EGR1 False True Regulation of PTEN gene transcription;Regulation of PTEN gene transcription;Interferon alpha/beta signaling 1962 EHHADH False True Beta-oxidation of very long chain fatty acids;Peroxisomal protein import;Peroxisomal protein import 1964 EIF1AX False True L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit 1965 EIF2S1 False True L13a-mediated translational silencing of Ceruloplasmin expression;PERK regulates gene expression;ABC-family proteins mediated transport;Translation initiation complex formation;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Recycling of eIF2:GDP 1967 EIF2B1 False True Recycling of eIF2:GDP 1969 EPHA2 False True EPH-Ephrin signaling;EPH-Ephrin signaling;EPHA-mediated growth cone collapse;EPHA-mediated growth cone collapse;EPH-ephrin mediated repulsion of cells;EPH-ephrin mediated repulsion of cells 1973 EIF4A1 True True ISG15 antiviral mechanism;L13a-mediated translational silencing of Ceruloplasmin expression;Deadenylation of mRNA;Translation initiation complex formation;Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit 1974 EIF4A2 False True ISG15 antiviral mechanism;L13a-mediated translational silencing of Ceruloplasmin expression;Deadenylation of mRNA;Translation initiation complex formation;Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit 1975 EIF4B False True L13a-mediated translational silencing of Ceruloplasmin expression;mTORC1-mediated signalling;Deadenylation of mRNA;Translation initiation complex formation;Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit 1977 EIF4E False True ISG15 antiviral mechanism;L13a-mediated translational silencing of Ceruloplasmin expression;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;mTORC1-mediated signalling;Deadenylation of mRNA;Translation initiation complex formation;Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit 1978 EIF4EBP1 False True mTORC1-mediated signalling;Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 1979 EIF4EBP2 False True NA 1981 EIF4G1 False True ISG15 antiviral mechanism;L13a-mediated translational silencing of Ceruloplasmin expression;mTORC1-mediated signalling;Deadenylation of mRNA;AUF1 (hnRNP D0) binds and destabilizes mRNA;Translation initiation complex formation;Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 1982 EIF4G2 False True ISG15 antiviral mechanism 1983 EIF5 False True Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit 1984 EIF5A False True Hypusine synthesis from eIF5A-lysine 1992 SERPINB1 True True Neutrophil degranulation 1994 ELAVL1 False True HuR (ELAVL1) binds and stabilizes mRNA;mRNA Splicing - Major Pathway 2001 ELF5 False True NA 2010 EMD False True Clearance of Nuclear Envelope Membranes from Chromatin;Initiation of Nuclear Envelope Reformation;Depolymerisation of the Nuclear Lamina 2011 MARK2 False True NA 2017 CTTN False True RHO GTPases activate PAKs;Clathrin-mediated endocytosis 2021 ENDOG False True NA 2023 ENO1 True True Glycolysis;Gluconeogenesis 2026 ENO2 False True Glycolysis;Gluconeogenesis 2027 ENO3 False True Glycolysis;Gluconeogenesis 2033 EP300 False True Regulation of gene expression by Hypoxia-inducible Factor;RORA activates gene expression;RORA activates gene expression;Polo-like kinase mediated events;Pre-NOTCH Transcription and Translation;Pre-NOTCH Transcription and Translation;PPARA activates gene expression;Formation of the beta-catenin:TCF transactivating complex;Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells;NOTCH1 Intracellular Domain Regulates Transcription;NOTCH1 Intracellular Domain Regulates Transcription;NOTCH2 intracellular domain regulates transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production;HATs acetylate histones;Attenuation phase;Transcriptional regulation of white adipocyte differentiation;Transcriptional regulation of white adipocyte differentiation;SUMOylation of transcription cofactors;Circadian Clock;Circadian Clock;B-WICH complex positively regulates rRNA expression;Activation of anterior HOX genes in hindbrain development during early embryogenesis;CD209 (DC-SIGN) signaling;Metalloprotease DUBs;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest;Regulation of TP53 Activity through Acetylation;Regulation of TP53 Activity through Methylation;PI5P Regulates TP53 Acetylation;Activation of the TFAP2 (AP-2) family of transcription factors;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known;RUNX3 regulates NOTCH signaling;RUNX3 regulates NOTCH signaling;Regulation of RUNX3 expression and activity;RUNX3 regulates p14-ARF;NOTCH3 Intracellular Domain Regulates Transcription;NOTCH3 Intracellular Domain Regulates Transcription;NOTCH4 Intracellular Domain Regulates Transcription;Estrogen-dependent gene expression;TRAF3-dependent IRF activation pathway;TRAF6 mediated IRF7 activation;FOXO-mediated transcription of cell death genes;Regulation of FOXO transcriptional activity by acetylation;Regulation of FOXO transcriptional activity by acetylation 2034 EPAS1 False True Regulation of gene expression by Hypoxia-inducible Factor;Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Transcriptional regulation of pluripotent stem cells;PTK6 Expression;Neddylation 2036 EPB41L1 False True Trafficking of AMPA receptors;Neurexins and neuroligins 2037 EPB41L2 False True Neurexins and neuroligins 2040 STOM False True Stimuli-sensing channels;Neutrophil degranulation 2041 EPHA1 False True EPH-Ephrin signaling;EPH-Ephrin signaling;POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation;EPHA-mediated growth cone collapse;EPHA-mediated growth cone collapse;EPH-ephrin mediated repulsion of cells;EPH-ephrin mediated repulsion of cells 2043 EPHA4 False True EPH-Ephrin signaling;EPH-Ephrin signaling;EPHA-mediated growth cone collapse;EPHA-mediated growth cone collapse;EPH-ephrin mediated repulsion of cells;EPH-ephrin mediated repulsion of cells 2047 EPHB1 False True EPH-Ephrin signaling;EPH-Ephrin signaling;EPHB-mediated forward signaling;EPHB-mediated forward signaling;Ephrin signaling;Ephrin signaling;EPH-ephrin mediated repulsion of cells 2051 EPHB6 False True EPH-Ephrin signaling;EPH-Ephrin signaling;EPHB-mediated forward signaling;EPHB-mediated forward signaling;Ephrin signaling;Ephrin signaling;EPH-ephrin mediated repulsion of cells 2054 STX2 False True NA 2058 EPRS False True SeMet incorporation into proteins;Cytosolic tRNA aminoacylation;tRNA modification in the nucleus and cytosol 2060 EPS15 False True EGFR downregulation;Negative regulation of MET activity;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;InlB-mediated entry of Listeria monocytogenes into host cell 2064 ERBB2 False True Signaling by ERBB2;SHC1 events in ERBB2 signaling;SHC1 events in ERBB2 signaling;PLCG1 events in ERBB2 signaling;PIP3 activates AKT signaling;GRB7 events in ERBB2 signaling;Downregulation of ERBB2:ERBB3 signaling;GRB2 events in ERBB2 signaling;GRB2 events in ERBB2 signaling;PI3K events in ERBB2 signaling;Constitutive Signaling by Aberrant PI3K in Cancer;Sema4D induced cell migration and growth-cone collapse;RAF/MAP kinase cascade;ERBB2 Regulates Cell Motility;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;ERBB2 Activates PTK6 Signaling;Downregulation of ERBB2 signaling;TFAP2 (AP-2) family regulates transcription of growth factors and their receptors 2065 ERBB3 False True Signaling by ERBB2;Signaling by ERBB4;SHC1 events in ERBB2 signaling;SHC1 events in ERBB2 signaling;PIP3 activates AKT signaling;GRB7 events in ERBB2 signaling;Downregulation of ERBB2:ERBB3 signaling;PI3K events in ERBB2 signaling;Constitutive Signaling by Aberrant PI3K in Cancer;RAF/MAP kinase cascade;ERBB2 Regulates Cell Motility;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;ERBB2 Activates PTK6 Signaling;Downregulation of ERBB2 signaling 2066 ERBB4 False True Signaling by ERBB2;Signaling by ERBB4;SHC1 events in ERBB2 signaling;SHC1 events in ERBB2 signaling;PI3K events in ERBB4 signaling;SHC1 events in ERBB4 signaling;Nuclear signaling by ERBB4;Nuclear signaling by ERBB4;Downregulation of ERBB4 signaling;PIP3 activates AKT signaling;GRB2 events in ERBB2 signaling;PI3K events in ERBB2 signaling;Constitutive Signaling by Aberrant PI3K in Cancer;RAF/MAP kinase cascade;ERBB2 Regulates Cell Motility;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;ERBB2 Activates PTK6 Signaling;Downregulation of ERBB2 signaling;Estrogen-dependent gene expression;Long-term potentiation 2073 ERCC5 False True Formation of Incision Complex in GG-NER;Dual Incision in GG-NER;Dual incision in TC-NER 2078 ERG False True NA 2079 ERH False True NA 2081 ERN1 False True IRE1alpha activates chaperones;IRE1alpha activates chaperones 2091 FBL False True rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol 2098 ESD False True Glutathione conjugation 2099 ESR1 False True Nuclear signaling by ERBB4;PIP3 activates AKT signaling;Constitutive Signaling by Aberrant PI3K in Cancer;Nuclear Receptor transcription pathway;SUMOylation of intracellular receptors;Ovarian tumor domain proteases;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;TFAP2 (AP-2) family regulates transcription of growth factors and their receptors;RUNX1 regulates estrogen receptor mediated transcription;ESR-mediated signaling;RUNX1 regulates transcription of genes involved in WNT signaling;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Estrogen-dependent gene expression 2103 ESRRB False True Nuclear Receptor transcription pathway 2107 ETF1 False True Eukaryotic Translation Termination;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 2108 ETFA False True Respiratory electron transport 2109 ETFB False True Respiratory electron transport;Protein methylation 2125 EVPL False True Formation of the cornified envelope 2130 EWSR1 False True NA 2147 F2 False True Intrinsic Pathway of Fibrin Clot Formation;Common Pathway of Fibrin Clot Formation;Gamma-carboxylation of protein precursors;Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus;Removal of aminoterminal propeptides from gamma-carboxylated proteins;Cell surface interactions at the vascular wall;Peptide ligand-binding receptors;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);G alpha (q) signalling events;Thrombin signalling through proteinase activated receptors (PARs);Platelet Aggregation (Plug Formation);Regulation of Complement cascade 2149 F2R False True Common Pathway of Fibrin Clot Formation;Peptide ligand-binding receptors;G alpha (q) signalling events;Thrombin signalling through proteinase activated receptors (PARs);Thrombin signalling through proteinase activated receptors (PARs) 2150 F2RL1 False True Peptide ligand-binding receptors;G alpha (q) signalling events 2155 F7 False True BMAL1:CLOCK,NPAS2 activates circadian gene expression;Extrinsic Pathway of Fibrin Clot Formation;Gamma-carboxylation of protein precursors;Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus;Removal of aminoterminal propeptides from gamma-carboxylated proteins 2170 FABP3 False True Triglyceride catabolism 2171 FABP5 True True Triglyceride catabolism;Signaling by Retinoic Acid;Neutrophil degranulation 2173 FABP7 False True Triglyceride catabolism;NOTCH3 Intracellular Domain Regulates Transcription 2175 FANCA False True Fanconi Anemia Pathway 2176 FANCC False True Fanconi Anemia Pathway;TP53 Regulates Transcription of DNA Repair Genes 2177 FANCD2 False True Fanconi Anemia Pathway;TP53 Regulates Transcription of DNA Repair Genes 2184 FAH False True Phenylalanine and tyrosine catabolism 2185 PTK2B False True Signal regulatory protein family interactions;VEGFA-VEGFR2 Pathway;Interleukin-2 signaling 2187 FANCB False True Fanconi Anemia Pathway 2189 FANCG False True Fanconi Anemia Pathway 2193 FARSA False True Cytosolic tRNA aminoacylation 2194 FASN False True ChREBP activates metabolic gene expression;Vitamin B5 (pantothenate) metabolism;Activation of gene expression by SREBF (SREBP);Fatty acyl-CoA biosynthesis;Fatty acyl-CoA biosynthesis 2202 EFEMP1 False True Molecules associated with elastic fibres;Molecules associated with elastic fibres 2203 FBP1 False True Gluconeogenesis 2205 FCER1A False True Fc epsilon receptor (FCERI) signaling;Fc epsilon receptor (FCERI) signaling;Role of LAT2/NTAL/LAB on calcium mobilization;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;FCERI mediated Ca+2 mobilization;FCERI mediated NF-kB activation 2207 FCER1G False True GPVI-mediated activation cascade;Cell surface interactions at the vascular wall;Fc epsilon receptor (FCERI) signaling;Fc epsilon receptor (FCERI) signaling;Role of LAT2/NTAL/LAB on calcium mobilization;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;FCERI mediated Ca+2 mobilization;FCERI mediated NF-kB activation;Dectin-2 family;Dectin-2 family;Neutrophil degranulation;Platelet Adhesion to exposed collagen 2217 FCGRT False True NA 2222 FDFT1 False True Cholesterol biosynthesis;PPARA activates gene expression;Activation of gene expression by SREBF (SREBP) 2224 FDPS False True Cholesterol biosynthesis;Activation of gene expression by SREBF (SREBP) 2237 FEN1 False True POLB-Dependent Long Patch Base Excision Repair;Early Phase of HIV Life Cycle;Removal of the Flap Intermediate from the C-strand;PCNA-Dependent Long Patch Base Excision Repair;HDR through MMEJ (alt-NHEJ);Removal of the Flap Intermediate 2241 FER False True Signaling by SCF-KIT 2242 FES False True Signaling by SCF-KIT;Sema3A PAK dependent Axon repulsion;SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion;CRMPs in Sema3A signaling 2243 FGA False True Platelet degranulation ;Common Pathway of Fibrin Clot Formation;Integrin cell surface interactions;Integrin alphaIIb beta3 signaling;GRB2:SOS provides linkage to MAPK signaling for Integrins ;p130Cas linkage to MAPK signaling for integrins;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);MAP2K and MAPK activation;Regulation of TLR by endogenous ligand;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF;Post-translational protein phosphorylation;Amyloid fiber formation 2257 FGF12 False True Phase 0 - rapid depolarisation 2260 FGFR1 False True PI3K Cascade;PIP3 activates AKT signaling;Signaling by FGFR1 amplification mutants;Signaling by activated point mutants of FGFR1;FGFR1b ligand binding and activation;FGFR1c ligand binding and activation;FGFR1c and Klotho ligand binding and activation;Constitutive Signaling by Aberrant PI3K in Cancer;NCAM signaling for neurite out-growth;Signal transduction by L1;Phospholipase C-mediated cascade: FGFR1;Downstream signaling of activated FGFR1;SHC-mediated cascade:FGFR1;PI-3K cascade:FGFR1;FRS-mediated FGFR1 signaling;Negative regulation of FGFR1 signaling;Signaling by FGFR1 in disease;RAF/MAP kinase cascade;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Signaling by plasma membrane FGFR1 fusions 2261 FGFR3 False True PI3K Cascade;PIP3 activates AKT signaling;Signaling by activated point mutants of FGFR3;FGFR3b ligand binding and activation;FGFR3c ligand binding and activation;FGFR3 mutant receptor activation;t(4;14) translocations of FGFR3;Constitutive Signaling by Aberrant PI3K in Cancer;Phospholipase C-mediated cascade; FGFR3;SHC-mediated cascade:FGFR3;FRS-mediated FGFR3 signaling;PI-3K cascade:FGFR3;Negative regulation of FGFR3 signaling;RAF/MAP kinase cascade;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Signaling by FGFR3 fusions in cancer;Signaling by FGFR3 point mutants in cancer 2268 FGR False True FCGR activation;Platelet sensitization by LDL;Neutrophil degranulation 2271 FH False True Citric acid cycle (TCA cycle) 2273 FHL1 False True NA 2274 FHL2 False True PPARA activates gene expression 2280 FKBP1A False True Calcineurin activates NFAT;TGF-beta receptor signaling activates SMADs;TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);TGFBR2 Kinase Domain Mutants in Cancer;TGFBR1 KD Mutants in Cancer;TGFBR1 LBD Mutants in Cancer 2281 FKBP1B False True Stimuli-sensing channels;Ion homeostasis 2286 FKBP2 False True NA 2288 FKBP4 False True HSP90 chaperone cycle for steroid hormone receptors (SHR);Attenuation phase;ESR-mediated signaling;Estrogen-dependent gene expression 2289 FKBP5 False True HSP90 chaperone cycle for steroid hormone receptors (SHR);ESR-mediated signaling;MECP2 regulates neuronal receptors and channels 2296 FOXC1 False True NA 2305 FOXM1 False True Polo-like kinase mediated events;Cyclin A/B1/B2 associated events during G2/M transition 2308 FOXO1 False True AKT phosphorylates targets in the nucleus;Regulation of gene expression in beta cells;AKT-mediated inactivation of FOXO1A;Constitutive Signaling by AKT1 E17K in Cancer;MAPK6/MAPK4 signaling;Interleukin-4 and Interleukin-13 signaling;Regulation of localization of FOXO transcription factors;FOXO-mediated transcription of cell death genes;FOXO-mediated transcription of cell death genes;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes;Regulation of FOXO transcriptional activity by acetylation;Regulation of FOXO transcriptional activity by acetylation;FOXO-mediated transcription of cell cycle genes;FOXO-mediated transcription of cell cycle genes 2309 FOXO3 False True Signaling by NODAL;AKT phosphorylates targets in the nucleus;Constitutive Signaling by AKT1 E17K in Cancer;MAPK6/MAPK4 signaling;Interleukin-4 and Interleukin-13 signaling;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;RUNX3 regulates BCL2L11 (BIM) transcription;Regulation of localization of FOXO transcription factors;FOXO-mediated transcription of cell death genes;FOXO-mediated transcription of cell death genes;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes;Regulation of FOXO transcriptional activity by acetylation;FOXO-mediated transcription of cell cycle genes;FOXO-mediated transcription of cell cycle genes 2312 NA True False Formation of the cornified envelope 2314 FLII False True NA 2316 FLNA False True Platelet degranulation ;GP1b-IX-V activation signalling;Cell-extracellular matrix interactions;RHO GTPases activate PAKs;OAS antiviral response 2317 FLNB True True ISG15 antiviral mechanism 2318 FLNC False True Cell-extracellular matrix interactions 2319 FLOT2 False True Synaptic adhesion-like molecules 2324 FLT4 False True VEGF binds to VEGFR leading to receptor dimerization;NOTCH4 Intracellular Domain Regulates Transcription 2335 FN1 False True Platelet degranulation ;Degradation of the extracellular matrix;Degradation of the extracellular matrix;Extracellular matrix organization;Fibronectin matrix formation;Cell surface interactions at the vascular wall;Molecules associated with elastic fibres;Integrin cell surface interactions;Syndecan interactions;Non-integrin membrane-ECM interactions;ECM proteoglycans;Integrin alphaIIb beta3 signaling;GRB2:SOS provides linkage to MAPK signaling for Integrins ;p130Cas linkage to MAPK signaling for integrins;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);MAP2K and MAPK activation;Interleukin-4 and Interleukin-13 signaling;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF;MET activates PTK2 signaling;Post-translational protein phosphorylation 2339 FNTA False True Apoptotic cleavage of cellular proteins;Inactivation, recovery and regulation of the phototransduction cascade 2342 FNTB False True Inactivation, recovery and regulation of the phototransduction cascade 2356 NA False True Metabolism of folate and pterines 2357 FPR1 False True G alpha (i) signalling events;Formyl peptide receptors bind formyl peptides and many other ligands;Interleukin-10 signaling;Neutrophil degranulation 2444 FRK False True Neutrophil degranulation;Regulation of PTEN stability and activity 2475 MTOR False True PIP3 activates AKT signaling;Macroautophagy;mTOR signalling;mTORC1-mediated signalling;HSF1-dependent transactivation;Energy dependent regulation of mTOR by LKB1-AMPK;CD28 dependent PI3K/Akt signaling;VEGFR2 mediated vascular permeability;TP53 Regulates Metabolic Genes;Constitutive Signaling by AKT1 E17K in Cancer;Regulation of TP53 Degradation;Regulation of PTEN gene transcription 2495 FTH1 False True Scavenging by Class A Receptors;Golgi Associated Vesicle Biogenesis;Neutrophil degranulation;Iron uptake and transport 2521 FUS False True mRNA Splicing - Major Pathway 2534 FYN False True GPVI-mediated activation cascade;Signaling by ERBB2;PIP3 activates AKT signaling;Signaling by SCF-KIT;Signaling by SCF-KIT;Regulation of KIT signaling;Nef and signal transduction;Cell surface interactions at the vascular wall;FCGR activation;PECAM1 interactions;Constitutive Signaling by Aberrant PI3K in Cancer;DAP12 signaling;DAP12 signaling;EPH-Ephrin signaling;Role of LAT2/NTAL/LAB on calcium mobilization;Nephrin family interactions;Nephrin family interactions;NCAM signaling for neurite out-growth;NCAM signaling for neurite out-growth;CD28 co-stimulation;CD28 dependent PI3K/Akt signaling;CD28 dependent Vav1 pathway;CTLA4 inhibitory signaling;EPHB-mediated forward signaling;EPHB-mediated forward signaling;EPHA-mediated growth cone collapse;EPHA-mediated growth cone collapse;Ephrin signaling;Ephrin signaling;EPH-ephrin mediated repulsion of cells;Sema3A PAK dependent Axon repulsion;SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion;SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion;CRMPs in Sema3A signaling;CRMPs in Sema3A signaling;DCC mediated attractive signaling;DCC mediated attractive signaling;VEGFA-VEGFR2 Pathway;Dectin-2 family;CD209 (DC-SIGN) signaling;RAF/MAP kinase cascade;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Platelet Adhesion to exposed collagen;Reelin signalling pathway;Activated NTRK2 signals through FYN;NTRK2 activates RAC1;NTRK2 activates RAC1;Regulation of signaling by CBL;Regulation of signaling by CBL;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 2535 FZD2 False True TCF dependent signaling in response to WNT;Class B/2 (Secretin family receptors);Ca2+ pathway;Ca2+ pathway;Asymmetric localization of PCP proteins;Disassembly of the destruction complex and recruitment of AXIN to the membrane;Disassembly of the destruction complex and recruitment of AXIN to the membrane;WNT5A-dependent internalization of FZD2, FZD5 and ROR2 2539 G6PD False True TP53 Regulates Metabolic Genes;Pentose phosphate pathway 2547 XRCC6 False True 2-LTR circle formation;Cytosolic sensors of pathogen-associated DNA ;IRF3-mediated induction of type I IFN;Nonhomologous End-Joining (NHEJ);Neutrophil degranulation 2548 GAA False True Glycogen storage disease type II (GAA);Neutrophil degranulation;Glycogen breakdown (glycogenolysis) 2549 GAB1 False True PI3K Cascade;Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants;PIP3 activates AKT signaling;GAB1 signalosome;PI3K events in ERBB2 signaling;Constitutive Signaling by Aberrant PI3K in Cancer;Constitutive Signaling by EGFRvIII;PI-3K cascade:FGFR1;PI-3K cascade:FGFR2;PI-3K cascade:FGFR3;PI-3K cascade:FGFR4;Signaling by FGFR2 in disease;Signaling by FGFR4 in disease;Signaling by FGFR1 in disease;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;MET activates PI3K/AKT signaling;Signaling by FGFR3 fusions in cancer;Signaling by FGFR3 point mutants in cancer;RET signaling;MET activates PTPN11;MET activates RAP1 and RAC1;MET receptor recycling;Erythropoietin activates Phosphoinositide-3-kinase (PI3K);Activated NTRK2 signals through PI3K 2550 GABBR1 False True Activation of G protein gated Potassium channels;G alpha (i) signalling events;Class C/3 (Metabotropic glutamate/pheromone receptors);GABA B receptor activation;Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 2553 GABPB1 False True Transcriptional activation of mitochondrial biogenesis 2560 GABRB1 False True GABA A receptor activation;GABA receptor activation 2580 GAK False True Golgi Associated Vesicle Biogenesis;Clathrin-mediated endocytosis 2590 GALNT2 False True COPI-independent Golgi-to-ER retrograde traffic;O-linked glycosylation of mucins 2597 GAPDH True True Glycolysis;Gluconeogenesis 2617 GARS False True Cytosolic tRNA aminoacylation;Mitochondrial tRNA aminoacylation 2618 GART False True Purine ribonucleoside monophosphate biosynthesis 2620 GAS2 False True Caspase-mediated cleavage of cytoskeletal proteins 2623 GATA1 False True RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Factors involved in megakaryocyte development and platelet production 2632 GBE1 False True Glycogen synthesis;Glycogen storage disease type IV (GBE1) 2634 GBP2 False True Interferon gamma signaling;Interferon alpha/beta signaling 2664 GDI1 False True Rho GTPase cycle;RAB GEFs exchange GTP for GDP on RABs 2665 GDI2 True True Rho GTPase cycle;Neutrophil degranulation;RAB GEFs exchange GTP for GDP on RABs 2670 GFAP False True Nuclear signaling by ERBB4 2673 GFPT1 False True XBP1(S) activates chaperone genes;Defective GFPT1 causes CMSTA1;Synthesis of UDP-N-acetyl-glucosamine 2706 GJB2 False True Oligomerization of connexins into connexons;Transport of connexins along the secretory pathway;Gap junction assembly;Transport of connexons to the plasma membrane 2709 GJB5 False True Gap junction assembly 2717 GLA False True Glycosphingolipid metabolism;Neutrophil degranulation 2739 GLO1 False True Pyruvate metabolism 2742 GLRA2 False True Neurotransmitter receptors and postsynaptic signal transmission 2744 GLS False True Glutamate Neurotransmitter Release Cycle;TP53 Regulates Metabolic Genes;Amino acid synthesis and interconversion (transamination) 2745 GLRX False True Interconversion of nucleotide di- and triphosphates 2770 GNAI1 False True PLC beta mediated events;PLC beta mediated events;Adenylate cyclase inhibitory pathway;Adenylate cyclase inhibitory pathway;G-protein activation;ADP signalling through P2Y purinoceptor 12;Adrenaline,noradrenaline inhibits insulin secretion;Adrenaline,noradrenaline inhibits insulin secretion;G alpha (s) signalling events;G alpha (i) signalling events;G alpha (i) signalling events;G alpha (z) signalling events;Regulation of insulin secretion;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 2771 GNAI2 False True PLC beta mediated events;PLC beta mediated events;Adenylate cyclase inhibitory pathway;Adenylate cyclase inhibitory pathway;G-protein activation;ADP signalling through P2Y purinoceptor 12;Adrenaline,noradrenaline inhibits insulin secretion;Adrenaline,noradrenaline inhibits insulin secretion;G alpha (s) signalling events;G alpha (i) signalling events;G alpha (i) signalling events;G alpha (z) signalling events;Regulation of insulin secretion;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 2773 GNAI3 False True PLC beta mediated events;PLC beta mediated events;Adenylate cyclase inhibitory pathway;Adenylate cyclase inhibitory pathway;G-protein activation;ADP signalling through P2Y purinoceptor 12;G alpha (s) signalling events;G alpha (i) signalling events;G alpha (i) signalling events;G alpha (z) signalling events;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 2778 GNAS False True Glucagon signaling in metabolic regulation;PKA activation in glucagon signalling;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Prostacyclin signalling through prostacyclin receptor;Prostacyclin signalling through prostacyclin receptor;G alpha (s) signalling events;G alpha (s) signalling events;G alpha (i) signalling events;G alpha (z) signalling events;Glucagon-type ligand receptors;Vasopressin regulates renal water homeostasis via Aquaporins;Hedgehog 'off' state 2782 GNB1 False True Activation of G protein gated Potassium channels;Glucagon signaling in metabolic regulation;G-protein activation;Activation of the phototransduction cascade;Activation of the phototransduction cascade;Inactivation, recovery and regulation of the phototransduction cascade;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Olfactory Signaling Pathway;ADP signalling through P2Y purinoceptor 12;G beta:gamma signalling through PI3Kgamma;Prostacyclin signalling through prostacyclin receptor;Prostacyclin signalling through prostacyclin receptor;Adrenaline,noradrenaline inhibits insulin secretion;Adrenaline,noradrenaline inhibits insulin secretion;Ca2+ pathway;Ca2+ pathway;G alpha (q) signalling events;G alpha (12/13) signalling events;G beta:gamma signalling through PLC beta;G alpha (s) signalling events;ADP signalling through P2Y purinoceptor 1;ADP signalling through P2Y purinoceptor 1;G alpha (i) signalling events;G alpha (z) signalling events;Glucagon-type ligand receptors;Thromboxane signalling through TP receptor;Vasopressin regulates renal water homeostasis via Aquaporins;Thrombin signalling through proteinase activated receptors (PARs);Thrombin signalling through proteinase activated receptors (PARs);Presynaptic function of Kainate receptors;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding;G beta:gamma signalling through BTK;G beta:gamma signalling through CDC42;Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 2783 GNB2 False True Activation of G protein gated Potassium channels;Glucagon signaling in metabolic regulation;G-protein activation;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;ADP signalling through P2Y purinoceptor 12;G beta:gamma signalling through PI3Kgamma;Prostacyclin signalling through prostacyclin receptor;Prostacyclin signalling through prostacyclin receptor;Adrenaline,noradrenaline inhibits insulin secretion;Adrenaline,noradrenaline inhibits insulin secretion;Ca2+ pathway;Ca2+ pathway;G alpha (q) signalling events;G alpha (12/13) signalling events;G beta:gamma signalling through PLC beta;G alpha (s) signalling events;ADP signalling through P2Y purinoceptor 1;ADP signalling through P2Y purinoceptor 1;G alpha (i) signalling events;G alpha (z) signalling events;Glucagon-type ligand receptors;Thromboxane signalling through TP receptor;Vasopressin regulates renal water homeostasis via Aquaporins;Thrombin signalling through proteinase activated receptors (PARs);Thrombin signalling through proteinase activated receptors (PARs);Presynaptic function of Kainate receptors;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding;G beta:gamma signalling through BTK;G beta:gamma signalling through CDC42;Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 2794 GNL1 False True NA 2801 GOLGA2 False True Golgi Cisternae Pericentriolar Stack Reorganization;Golgi Cisternae Pericentriolar Stack Reorganization;COPII-mediated vesicle transport;COPI-mediated anterograde transport;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models 2803 GOLGA4 False True Retrograde transport at the Trans-Golgi-Network 2805 GOT1 False True Methionine salvage pathway;Gluconeogenesis;Amino acid synthesis and interconversion (transamination) 2806 GOT2 False True Degradation of cysteine and homocysteine;Glyoxylate metabolism and glycine degradation;Gluconeogenesis;Amino acid synthesis and interconversion (transamination) 2810 SFN True True Activation of BAD and translocation to mitochondria ;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Translocation of SLC2A4 (GLUT4) to the plasma membrane;RHO GTPases activate PKNs;TP53 Regulates Metabolic Genes;TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;Regulation of localization of FOXO transcription factors 2811 GP1BA False True Intrinsic Pathway of Fibrin Clot Formation;GP1b-IX-V activation signalling;Platelet Adhesion to exposed collagen;Platelet Aggregation (Plug Formation);RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 2812 GP1BB False True Intrinsic Pathway of Fibrin Clot Formation;GP1b-IX-V activation signalling;Platelet Adhesion to exposed collagen;Platelet Aggregation (Plug Formation) 2821 GPI False True TP53 Regulates Metabolic Genes;Neutrophil degranulation;Glycolysis;Gluconeogenesis 2848 GPR25 False True G alpha (s) signalling events 2861 GPR37 False True Peptide ligand-binding receptors;G alpha (i) signalling events 2868 GRK4 False True Inactivation, recovery and regulation of the phototransduction cascade 2870 GRK6 False True G alpha (s) signalling events 2875 GPT False True Amino acid synthesis and interconversion (transamination) 2879 GPX4 False True Synthesis of 5-eicosatetraenoic acids;Synthesis of 12-eicosatetraenoic acid derivatives;Synthesis of 15-eicosatetraenoic acid derivatives;Biosynthesis of D-series resolvins;Biosynthesis of E-series 18(S)-resolvins;Biosynthesis of aspirin-triggered D-series resolvins;Biosynthesis of E-series 18(R)-resolvins 2882 GPX7 False True Detoxification of Reactive Oxygen Species 2885 GRB2 False True PI3K Cascade;SOS-mediated signalling;SOS-mediated signalling;Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants;SHC1 events in ERBB2 signaling;SHC1 events in ERBB4 signaling;PIP3 activates AKT signaling;Spry regulation of FGF signaling;Signaling by SCF-KIT;Regulation of KIT signaling;Signalling to RAS;Signalling to RAS;GRB2 events in EGFR signaling;GAB1 signalosome;SHC1 events in EGFR signaling;EGFR downregulation;Signaling by cytosolic FGFR1 fusion mutants;Downstream signal transduction;GRB2 events in ERBB2 signaling;GRB2 events in ERBB2 signaling;PI3K events in ERBB2 signaling;Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;Tie2 Signaling;EGFR Transactivation by Gastrin;Constitutive Signaling by Aberrant PI3K in Cancer;DAP12 signaling;SHC-related events triggered by IGF1R;SHC-related events triggered by IGF1R;Role of LAT2/NTAL/LAB on calcium mobilization;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;FCERI mediated Ca+2 mobilization;GRB2:SOS provides linkage to MAPK signaling for Integrins ;NCAM signaling for neurite out-growth;Costimulation by the CD28 family;CD28 dependent Vav1 pathway;Signal regulatory protein family interactions;Interleukin-3, Interleukin-5 and GM-CSF signaling;Constitutive Signaling by EGFRvIII;SHC-mediated cascade:FGFR1;PI-3K cascade:FGFR1;FRS-mediated FGFR1 signaling;PI-3K cascade:FGFR2;SHC-mediated cascade:FGFR2;FRS-mediated FGFR2 signaling;SHC-mediated cascade:FGFR3;FRS-mediated FGFR3 signaling;PI-3K cascade:FGFR3;FRS-mediated FGFR4 signaling;SHC-mediated cascade:FGFR4;PI-3K cascade:FGFR4;Negative regulation of FGFR1 signaling;Negative regulation of FGFR2 signaling;Negative regulation of FGFR3 signaling;Negative regulation of FGFR4 signaling;Signaling by FGFR2 in disease;Signaling by FGFR4 in disease;Signaling by FGFR1 in disease;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs;RAF/MAP kinase cascade;Negative regulation of MET activity;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Signal attenuation;Insulin receptor signalling cascade;Insulin receptor signalling cascade;MET activates RAS signaling;MET activates PI3K/AKT signaling;Signaling by FGFR3 fusions in cancer;Signaling by FGFR3 point mutants in cancer;RET signaling;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;MET activates PTPN11;InlB-mediated entry of Listeria monocytogenes into host cell;InlB-mediated entry of Listeria monocytogenes into host cell;MET activates RAP1 and RAC1;MET receptor recycling;Interleukin-15 signaling;Interleukin-15 signaling;Activated NTRK2 signals through RAS;Erythropoietin activates RAS;Erythropoietin activates RAS;Activated NTRK2 signals through PI3K;Activated NTRK2 signals through FRS2 and FRS3;Activated NTRK2 signals through FRS2 and FRS3;Activated NTRK3 signals through RAS;Interleukin receptor SHC signaling;Regulation of signaling by CBL;Regulation of signaling by CBL;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 2886 GRB7 False True GRB7 events in ERBB2 signaling;Signaling by SCF-KIT;Downstream signal transduction;Tie2 Signaling;RET signaling 2887 GRB10 False True Signaling by SCF-KIT;IRS activation;Signal attenuation;Insulin receptor signalling cascade;RET signaling 2904 GRIN2B False True EPHB-mediated forward signaling;EPHB-mediated forward signaling;Unblocking of NMDA receptors, glutamate binding and activation;Unblocking of NMDA receptors, glutamate binding and activation;Ras activation upon Ca2+ influx through NMDA receptor;RAF/MAP kinase cascade;Neurexins and neuroligins;Synaptic adhesion-like molecules;MECP2 regulates neuronal receptors and channels;Activated NTRK2 signals through FYN;Negative regulation of NMDA receptor-mediated neuronal transmission;Long-term potentiation 2908 NR3C1 False True HSP90 chaperone cycle for steroid hormone receptors (SHR);Nuclear Receptor transcription pathway;Circadian Clock;SUMOylation of intracellular receptors;PTK6 Expression;Regulation of RUNX2 expression and activity;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 2912 GRM2 False True G alpha (i) signalling events;Class C/3 (Metabotropic glutamate/pheromone receptors) 2923 PDIA3 False True ER-Phagosome pathway;ER-Phagosome pathway;Calnexin/calreticulin cycle;Antigen Presentation: Folding, assembly and peptide loading of class I MHC;Antigen Presentation: Folding, assembly and peptide loading of class I MHC 2931 GSK3A False True AKT phosphorylates targets in the cytosol;XBP1(S) activates chaperone genes;Constitutive Signaling by AKT1 E17K in Cancer 2934 GSN True True Caspase-mediated cleavage of cytoskeletal proteins;Neutrophil degranulation;Amyloid fiber formation 2935 GSPT1 False True Eukaryotic Translation Termination;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 2936 GSR False True Metabolism of ingested H2SeO4 and H2SeO3 into H2Se;Detoxification of Reactive Oxygen Species;Interconversion of nucleotide di- and triphosphates;TP53 Regulates Metabolic Genes 2937 GSS True True Glutathione synthesis and recycling;Defective GSS causes Glutathione synthetase deficiency (GSS deficiency) 2947 GSTM3 False True Glutathione conjugation 2950 GSTP1 True True Glutathione conjugation;Detoxification of Reactive Oxygen Species;Neutrophil degranulation 2952 GSTT1 False True Glutathione conjugation 2954 GSTZ1 False True Glutathione conjugation;Regulation of pyruvate dehydrogenase (PDH) complex;Phenylalanine and tyrosine catabolism 2956 MSH6 False True Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha);Defective Mismatch Repair Associated With MSH2;Defective Mismatch Repair Associated With MSH6 2957 GTF2A1 False True HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;RNA Polymerase II Pre-transcription Events;RNA polymerase II transcribes snRNA genes;RNA polymerase II transcribes snRNA genes;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;Estrogen-dependent gene expression 2959 GTF2B False True HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;RNA Polymerase II Pre-transcription Events;RNA polymerase II transcribes snRNA genes;RNA polymerase II transcribes snRNA genes;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance 2963 GTF2F2 False True Formation of RNA Pol II elongation complex ;Formation of the Early Elongation Complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of the HIV-1 Early Elongation Complex;RNA Pol II CTD phosphorylation and interaction with CE during HIV infection;HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;Formation of HIV-1 elongation complex containing HIV-1 Tat;Formation of HIV-1 elongation complex containing HIV-1 Tat;Pausing and recovery of Tat-mediated HIV elongation;Abortive elongation of HIV-1 transcript in the absence of Tat;Tat-mediated HIV elongation arrest and recovery;Tat-mediated elongation of the HIV-1 transcript;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;Viral Messenger RNA Synthesis;RNA Polymerase II Pre-transcription Events;TP53 Regulates Transcription of DNA Repair Genes;FGFR2 alternative splicing;RNA polymerase II transcribes snRNA genes;RNA polymerase II transcribes snRNA genes;mRNA Capping;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;Processing of Capped Intron-Containing Pre-mRNA;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Elongation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Pol II CTD phosphorylation and interaction with CE;Signaling by FGFR2 IIIa TM;Estrogen-dependent gene expression 2978 NA False True Inactivation, recovery and regulation of the phototransduction cascade 2983 GUCY1B3 False True Nitric oxide stimulates guanylate cyclase;Smooth Muscle Contraction 3005 H1F0 False True Activation of DNA fragmentation factor;Formation of Senescence-Associated Heterochromatin Foci (SAHF) 3006 HIST1H1C False True Activation of DNA fragmentation factor;Formation of Senescence-Associated Heterochromatin Foci (SAHF) 3007 NA False True Activation of DNA fragmentation factor;Formation of Senescence-Associated Heterochromatin Foci (SAHF) 3008 HIST1H1E False True Activation of DNA fragmentation factor;Formation of Senescence-Associated Heterochromatin Foci (SAHF) 3009 HIST1H1B False True Activation of DNA fragmentation factor;Formation of Senescence-Associated Heterochromatin Foci (SAHF) 3012 NA False True Meiotic synapsis;Packaging Of Telomere Ends;Pre-NOTCH Transcription and Translation;Formation of the beta-catenin:TCF transactivating complex;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;HDACs deacetylate histones;HATs acetylate histones;HATs acetylate histones;RMTs methylate histone arginines;SIRT1 negatively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;NoRC negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;B-WICH complex positively regulates rRNA expression;DNA methylation;Transcriptional regulation by small RNAs;Activation of anterior HOX genes in hindbrain development during early embryogenesis;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;UCH proteinases;Ub-specific processing proteases;Metalloprotease DUBs;Deposition of new CENPA-containing nucleosomes at the centromere;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Estrogen-dependent gene expression;Meiotic recombination;Amyloid fiber formation 3014 H2AFX False True Meiotic synapsis;Packaging Of Telomere Ends;Pre-NOTCH Transcription and Translation;Formation of the beta-catenin:TCF transactivating complex;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;RMTs methylate histone arginines;SIRT1 negatively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;NoRC negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;B-WICH complex positively regulates rRNA expression;DNA methylation;Transcriptional regulation by small RNAs;Activation of anterior HOX genes in hindbrain development during early embryogenesis;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Processing of DNA double-strand break ends;Deposition of new CENPA-containing nucleosomes at the centromere;G2/M DNA damage checkpoint;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Estrogen-dependent gene expression;Meiotic recombination;Amyloid fiber formation 3015 H2AFZ False True Meiotic synapsis;Packaging Of Telomere Ends;Pre-NOTCH Transcription and Translation;Formation of the beta-catenin:TCF transactivating complex;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;RMTs methylate histone arginines;SIRT1 negatively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;NoRC negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;B-WICH complex positively regulates rRNA expression;DNA methylation;Transcriptional regulation by small RNAs;Activation of anterior HOX genes in hindbrain development during early embryogenesis;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Deposition of new CENPA-containing nucleosomes at the centromere;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Estrogen-dependent gene expression;Meiotic recombination;Amyloid fiber formation 3018 HIST1H2BB False True Meiotic synapsis;Packaging Of Telomere Ends;Pre-NOTCH Transcription and Translation;Formation of the beta-catenin:TCF transactivating complex;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;HDACs deacetylate histones;HATs acetylate histones;HATs acetylate histones;SIRT1 negatively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;NoRC negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;B-WICH complex positively regulates rRNA expression;DNA methylation;Transcriptional regulation by small RNAs;Activation of anterior HOX genes in hindbrain development during early embryogenesis;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Ub-specific processing proteases;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Processing of DNA double-strand break ends;Deposition of new CENPA-containing nucleosomes at the centromere;G2/M DNA damage checkpoint;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;E3 ubiquitin ligases ubiquitinate target proteins;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Estrogen-dependent gene expression;Meiotic recombination;Amyloid fiber formation 3024 HIST1H1A False True Activation of DNA fragmentation factor;Formation of Senescence-Associated Heterochromatin Foci (SAHF) 3028 HSD17B10 False True tRNA processing in the mitochondrion;tRNA modification in the mitochondrion;Branched-chain amino acid catabolism;rRNA processing in the mitochondrion 3029 HAGH False True Pyruvate metabolism 3032 HADHB False True Acyl chain remodeling of CL;Beta oxidation of myristoyl-CoA to lauroyl-CoA;mitochondrial fatty acid beta-oxidation of unsaturated fatty acids;Beta oxidation of palmitoyl-CoA to myristoyl-CoA;Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA;Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA;Beta oxidation of octanoyl-CoA to hexanoyl-CoA;Beta oxidation of hexanoyl-CoA to butanoyl-CoA 3034 HAL True True Histidine catabolism 3035 HARS False True Cytosolic tRNA aminoacylation 3039 HBA1 False True Erythrocytes take up carbon dioxide and release oxygen;Erythrocytes take up oxygen and release carbon dioxide;Scavenging of heme from plasma 3040 HBA2 False True Erythrocytes take up carbon dioxide and release oxygen;Erythrocytes take up oxygen and release carbon dioxide;Scavenging of heme from plasma 3043 HBB True True Erythrocytes take up carbon dioxide and release oxygen;Erythrocytes take up oxygen and release carbon dioxide;Scavenging of heme from plasma;Neutrophil degranulation;Factors involved in megakaryocyte development and platelet production 3054 HCFC1 False True Transcriptional activation of mitochondrial biogenesis;HATs acetylate histones;UCH proteinases 3055 HCK False True Nef and signal transduction;FCGR activation;Regulation of signaling by CBL;Regulation of signaling by CBL 3064 HTT False True Regulation of MECP2 expression and activity 3065 HDAC1 False True Transcription of E2F targets under negative control by DREAM complex;Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1;G0 and Early G1;p75NTR negatively regulates cell cycle via SC1;Formation of the beta-catenin:TCF transactivating complex;NOTCH1 Intracellular Domain Regulates Transcription;Downregulation of SMAD2/3:SMAD4 transcriptional activity;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;HDACs deacetylate histones;Deactivation of the beta-catenin transactivating complex;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;NoRC negatively regulates rRNA expression;SUMOylation of chromatin organization proteins;Repression of WNT target genes;Repression of WNT target genes;Activation of E2F1 target genes at G1/S;Regulation of TP53 Activity through Acetylation;RNA Polymerase I Transcription Initiation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Regulation of PTEN gene transcription;Regulation of PTEN gene transcription;Estrogen-dependent gene expression;Loss of MECP2 binding ability to 5mC-DNA;Regulation of MECP2 expression and activity;MECP2 regulates neuronal receptors and channels;MECP2 regulates transcription of neuronal ligands;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes;Factors involved in megakaryocyte development and platelet production 3066 HDAC2 False True p75NTR negatively regulates cell cycle via SC1;NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;HDACs deacetylate histones;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;NoRC negatively regulates rRNA expression;SUMOylation of chromatin organization proteins;Regulation of TP53 Activity through Acetylation;RNA Polymerase I Transcription Initiation;Regulation of PTEN gene transcription;Regulation of PTEN gene transcription;Regulation of MECP2 expression and activity;MECP2 regulates neuronal receptors and channels;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes;Factors involved in megakaryocyte development and platelet production 3068 HDGF False True XBP1(S) activates chaperone genes 3069 HDLBP False True HDL clearance 3070 HELLS False True NA 3074 HEXB False True Glycosphingolipid metabolism;Keratan sulfate degradation;CS/DS degradation;Hyaluronan uptake and degradation;Defective HEXB causes GM2G2;Neutrophil degranulation 3075 CFH False True Regulation of Complement cascade 3091 HIF1A False True Regulation of gene expression by Hypoxia-inducible Factor;Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;NOTCH1 Intracellular Domain Regulates Transcription;Circadian Clock;Ub-specific processing proteases;Interleukin-4 and Interleukin-13 signaling;PTK6 Expression;PTK6 promotes HIF1A stabilization;Neddylation 3092 HIP1 False True Clathrin-mediated endocytosis 3093 UBE2K False True Synthesis of active ubiquitin: roles of E1 and E2 enzymes;Negative regulators of DDX58/IFIH1 signaling;Antigen processing: Ubiquitination & Proteasome degradation 3094 HINT1 False True NA 3096 HIVEP1 False True NA 3097 NA False True NA 3099 HK2 False True Glycolysis 3101 HK3 False True Neutrophil degranulation;Glycolysis 3115 HLA-DPB1 False True Downstream TCR signaling;Phosphorylation of CD3 and TCR zeta chains;Translocation of ZAP-70 to Immunological synapse;Generation of second messenger molecules;MHC class II antigen presentation;PD-1 signaling;Interferon gamma signaling 3146 HMGB1 False True Activation of DNA fragmentation factor;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;Regulation of TLR by endogenous ligand;Neutrophil degranulation;Advanced glycosylation endproduct receptor signaling;Advanced glycosylation endproduct receptor signaling;TRAF6 mediated NF-kB activation 3149 HMGB3 False True NA 3157 HMGCS1 False True Cholesterol biosynthesis;PPARA activates gene expression;Activation of gene expression by SREBF (SREBP) 3159 HMGA1 False True Integration of provirus;2-LTR circle formation;Integration of viral DNA into host genomic DNA;Autointegration results in viral DNA circles;APOBEC3G mediated resistance to HIV-1 infection;Vpr-mediated nuclear import of PICs;Formation of Senescence-Associated Heterochromatin Foci (SAHF) 3162 HMOX1 False True Heme degradation;Interleukin-4 and Interleukin-13 signaling;Iron uptake and transport 3163 HMOX2 False True Heme degradation;Neutrophil degranulation;Iron uptake and transport 3176 NA False True Metabolism of ingested SeMet, Sec, MeSec into H2Se;Histidine catabolism 3178 HNRNPA1 False True FGFR2 alternative splicing;mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA 3181 HNRNPA2B1 False True mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 3182 HNRNPAB False True NA 3183 HNRNPC False True SUMOylation of RNA binding proteins;mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA 3184 HNRNPD False True AUF1 (hnRNP D0) binds and destabilizes mRNA;mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA 3185 HNRNPF False True FGFR2 alternative splicing;mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 3187 HNRNPH1 False True FGFR2 alternative splicing;mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA 3188 HNRNPH2 False True mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA 3189 HNRNPH3 False True NA 3190 HNRNPK False True SUMOylation of RNA binding proteins;mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA 3191 HNRNPL False True mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA 3192 HNRNPU False True mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA 3199 HOXA2 False True Activation of anterior HOX genes in hindbrain development during early embryogenesis;Regulation of expression of SLITs and ROBOs 3240 HP True True Scavenging of heme from plasma;Neutrophil degranulation 3263 HPX False True Scavenging of heme from plasma 3280 HES1 False True Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells;NOTCH1 Intracellular Domain Regulates Transcription;NOTCH2 intracellular domain regulates transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;RUNX2 regulates osteoblast differentiation;RUNX3 regulates NOTCH signaling;RUNX3 regulates NOTCH signaling;NOTCH3 Intracellular Domain Regulates Transcription;NOTCH4 Intracellular Domain Regulates Transcription 3295 HSD17B4 False True Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol;alpha-linolenic acid (ALA) metabolism;Beta-oxidation of pristanoyl-CoA;Beta-oxidation of very long chain fatty acids;Peroxisomal protein import;Peroxisomal protein import;TYSND1 cleaves peroxisomal proteins 3297 HSF1 False True Regulation of HSF1-mediated heat shock response;HSF1 activation;Attenuation phase;HSF1-dependent transactivation 3301 DNAJA1 False True HSP90 chaperone cycle for steroid hormone receptors (SHR) 3303 HSPA1A True True Viral RNP Complexes in the Host Cell Nucleus;Regulation of HSF1-mediated heat shock response;HSP90 chaperone cycle for steroid hormone receptors (SHR);Attenuation phase;HSF1-dependent transactivation;AUF1 (hnRNP D0) binds and destabilizes mRNA;Neutrophil degranulation 3304 HSPA1B True True Viral RNP Complexes in the Host Cell Nucleus;Regulation of HSF1-mediated heat shock response;HSP90 chaperone cycle for steroid hormone receptors (SHR);Attenuation phase;HSF1-dependent transactivation;AUF1 (hnRNP D0) binds and destabilizes mRNA;Neutrophil degranulation 3305 HSPA1L False True Regulation of HSF1-mediated heat shock response;HSP90 chaperone cycle for steroid hormone receptors (SHR);Attenuation phase;HSF1-dependent transactivation 3306 HSPA2 False True Meiotic synapsis;Regulation of HSF1-mediated heat shock response;HSP90 chaperone cycle for steroid hormone receptors (SHR);Attenuation phase 3308 HSPA4 False True Regulation of HSF1-mediated heat shock response 3309 HSPA5 True True Platelet degranulation ;Regulation of HSF1-mediated heat shock response;ATF6 (ATF6-alpha) activates chaperones;PERK regulates gene expression;IRE1alpha activates chaperones;ATF6 (ATF6-alpha) activates chaperone genes;Antigen Presentation: Folding, assembly and peptide loading of class I MHC;Antigen Presentation: Folding, assembly and peptide loading of class I MHC 3310 HSPA6 False True Regulation of HSF1-mediated heat shock response;Neutrophil degranulation 3311 NA False True NA 3312 HSPA8 True True Regulation of HSF1-mediated heat shock response;HSP90 chaperone cycle for steroid hormone receptors (SHR);Attenuation phase;HSF1-dependent transactivation;Lysosome Vesicle Biogenesis;Golgi Associated Vesicle Biogenesis;CHL1 interactions;AUF1 (hnRNP D0) binds and destabilizes mRNA;Interleukin-4 and Interleukin-13 signaling;Neutrophil degranulation;mRNA Splicing - Major Pathway;Clathrin-mediated endocytosis;Protein methylation;GABA synthesis, release, reuptake and degradation 3313 HSPA9 False True Mitochondrial protein import;Regulation of HSF1-mediated heat shock response;Cristae formation;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 3315 HSPB1 True True VEGFA-VEGFR2 Pathway;AUF1 (hnRNP D0) binds and destabilizes mRNA;MAPK6/MAPK4 signaling 3320 HSP90AA1 True True Signaling by ERBB2;Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants;Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation;vRNP Assembly;Regulation of actin dynamics for phagocytic cup formation;eNOS activation;Regulation of PLK1 Activity at G2/M Transition;Scavenging by Class F Receptors;Scavenging by Class F Receptors;HSP90 chaperone cycle for steroid hormone receptors (SHR);HSF1 activation;Attenuation phase;HSF1-dependent transactivation;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Sema3A PAK dependent Axon repulsion;VEGFA-VEGFR2 Pathway;VEGFA-VEGFR2 Pathway;VEGFR2 mediated vascular permeability;Uptake and function of diphtheria toxin;PIWI-interacting RNA (piRNA) biogenesis;Anchoring of the basal body to the plasma membrane;Constitutive Signaling by EGFRvIII;Interleukin-4 and Interleukin-13 signaling;Neutrophil degranulation;The role of GTSE1 in G2/M progression after G2 checkpoint;AURKA Activation by TPX2;Downregulation of ERBB2 signaling;ESR-mediated signaling;Estrogen-dependent gene expression 3326 HSP90AB1 False True Regulation of actin dynamics for phagocytic cup formation;HSP90 chaperone cycle for steroid hormone receptors (SHR);HSF1 activation;Attenuation phase;HSF1-dependent transactivation;Sema3A PAK dependent Axon repulsion;Uptake and function of diphtheria toxin;Neutrophil degranulation;The NLRP3 inflammasome;The role of GTSE1 in G2/M progression after G2 checkpoint;Aryl hydrocarbon receptor signalling;ESR-mediated signaling;Estrogen-dependent gene expression 3329 HSPD1 False True Mitochondrial protein import;Mitochondrial protein import;TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation 3336 HSPE1 False True NA 3337 DNAJB1 False True Regulation of HSF1-mediated heat shock response;HSP90 chaperone cycle for steroid hormone receptors (SHR);Attenuation phase;HSF1-dependent transactivation;MAPK6/MAPK4 signaling 3346 NA False True Antimicrobial peptides 3347 HTN3 False True Antimicrobial peptides 3376 IARS False True SeMet incorporation into proteins;Cytosolic tRNA aminoacylation 3398 ID2 False True NA 3416 IDE True True Ub-specific processing proteases;Peroxisomal protein import;Peroxisomal protein import 3419 IDH3A False True Citric acid cycle (TCA cycle) 3433 IFIT2 False True Interferon alpha/beta signaling 3441 IFNA4 False True Interferon alpha/beta signaling;Regulation of IFNA signaling;Regulation of IFNA signaling;TRAF6 mediated IRF7 activation;Factors involved in megakaryocyte development and platelet production 3476 IGBP1 False True NA 3479 IGF1 False True Platelet degranulation ;Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R);IRS-related events triggered by IGF1R;SHC-related events triggered by IGF1R;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Synthesis, secretion, and deacylation of Ghrelin 3480 IGF1R False True Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R);IRS-related events triggered by IGF1R;SHC-related events triggered by IGF1R 3481 IGF2 False True Platelet degranulation ;Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R);IRS-related events triggered by IGF1R;SHC-related events triggered by IGF1R;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 3488 IGFBP5 False True Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation 3491 NA False True Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation 3500 IGHG1 False True NA 3501 NA False True NA 3514 IGKC False True NA 3516 RBPJ False True Pre-NOTCH Transcription and Translation;Pre-NOTCH Transcription and Translation;Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells;NOTCH1 Intracellular Domain Regulates Transcription;NOTCH1 Intracellular Domain Regulates Transcription;NOTCH2 intracellular domain regulates transcription;NOTCH2 intracellular domain regulates transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Notch-HLH transcription pathway;RUNX3 regulates NOTCH signaling;RUNX3 regulates NOTCH signaling;NOTCH3 Intracellular Domain Regulates Transcription;NOTCH3 Intracellular Domain Regulates Transcription;NOTCH4 Intracellular Domain Regulates Transcription;NOTCH4 Intracellular Domain Regulates Transcription 3535 IGL False True NA 3551 IKBKB False True Activation of NF-kappaB in B cells;Activation of NF-kappaB in B cells;ER-Phagosome pathway;NOD1/2 Signaling Pathway;TICAM1, RIP1-mediated IKK complex recruitment ;RIP-mediated NFkB activation via ZBP1;Downstream TCR signaling;p75NTR recruits signalling complexes;NF-kB is activated and signals survival;FCERI mediated NF-kB activation;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;IKBKB deficiency causes SCID;IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR);IkBA variant leads to EDA-ID;CLEC7A (Dectin-1) signaling;MAP3K8 (TPL2)-dependent MAPK1/3 activation;Interleukin-1 signaling;TRAF6 mediated NF-kB activation;NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10;IRAK1 recruits IKK complex;IKK complex recruitment mediated by RIP1;IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 3557 NA True False Interleukin-10 signaling;Interleukin-1 signaling 3575 IL7R False True Interleukin-7 signaling;Interleukin-7 signaling;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis 3581 IL9R False True Interleukin-9 signaling 3608 ILF2 False True Neutrophil degranulation 3609 ILF3 False True NA 3611 ILK False True Localization of the PINCH-ILK-PARVIN complex to focal adhesions;Cell-extracellular matrix interactions 3613 IMPA2 False True Synthesis of IP2, IP, and Ins in the cytosol 3614 IMPDH1 False True Neutrophil degranulation;Purine ribonucleoside monophosphate biosynthesis 3615 IMPDH2 False True Neutrophil degranulation;Purine ribonucleoside monophosphate biosynthesis 3621 ING1 False True NA 3630 INS False True Regulation of gene expression in beta cells;Insulin processing;Insulin processing;Synthesis, secretion, and deacylation of Ghrelin;Regulation of insulin secretion;COPI-mediated anterograde transport;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;IRS activation;Signal attenuation;Insulin receptor signalling cascade;Signaling by Insulin receptor;Insulin receptor recycling;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes;Amyloid fiber formation 3632 INPP5A False True Synthesis of IP2, IP, and Ins in the cytosol 3636 INPPL1 False True Synthesis of PIPs at the plasma membrane;Synthesis of IP3 and IP4 in the cytosol;Interleukin receptor SHC signaling 3645 INSRR False True NA 3646 EIF3E False True L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit 3656 IRAK2 False True MyD88:MAL(TIRAP) cascade initiated on plasma membrane;NOD1/2 Signaling Pathway;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;activated TAK1 mediates p38 MAPK activation;JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1;Interleukin-1 signaling;IRAK2 mediated activation of TAK1 complex;TRAF6-mediated induction of TAK1 complex within TLR4 complex;TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation;MyD88 dependent cascade initiated on endosome;IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation;MyD88 cascade initiated on plasma membrane 3658 IREB2 False True Iron uptake and transport 3660 IRF2 False True Interferon gamma signaling;Interferon alpha/beta signaling;Factors involved in megakaryocyte development and platelet production 3661 IRF3 False True ISG15 antiviral mechanism;IRF3 mediated activation of type 1 IFN;IRF3 mediated activation of type 1 IFN;LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production;Regulation of innate immune responses to cytosolic DNA;IRF3-mediated induction of type I IFN;Interferon gamma signaling;TICAM1-dependent activation of IRF3/IRF7;Interferon alpha/beta signaling;TRAF3-dependent IRF activation pathway;TRAF6 mediated IRF7 activation;Negative regulators of DDX58/IFIH1 signaling;Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon 3667 IRS1 False True PI3K Cascade;IRS-mediated signalling;SOS-mediated signalling;SOS-mediated signalling;PIP3 activates AKT signaling;Interleukin-7 signaling;PI3K/AKT activation;PI3K/AKT activation;Constitutive Signaling by Aberrant PI3K in Cancer;IRS-related events triggered by IGF1R;Signaling by Leptin;RAF/MAP kinase cascade;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;IRS activation;Signal attenuation;Activated NTRK3 signals through PI3K;Growth hormone receptor signaling 3673 ITGA2 False True Integrin cell surface interactions;Integrin cell surface interactions;Laminin interactions;Laminin interactions;Syndecan interactions;ECM proteoglycans;CHL1 interactions;Platelet Adhesion to exposed collagen;MET activates PTK2 signaling 3684 ITGAM False True Toll Like Receptor 4 (TLR4) Cascade;Cell surface interactions at the vascular wall;Integrin cell surface interactions;Interleukin-4 and Interleukin-13 signaling;Neutrophil degranulation 3685 ITGAV False True Cross-presentation of particulate exogenous antigens (phagosomes);Elastic fibre formation;PECAM1 interactions;Molecules associated with elastic fibres;Integrin cell surface interactions;Integrin cell surface interactions;Laminin interactions;Syndecan interactions;Syndecan interactions;ECM proteoglycans;VEGFA-VEGFR2 Pathway;Signal transduction by L1;Neutrophil degranulation 3688 ITGB1 False True Elastic fibre formation;Fibronectin matrix formation;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Cell surface interactions at the vascular wall;Basigin interactions;Molecules associated with elastic fibres;Integrin cell surface interactions;Integrin cell surface interactions;Laminin interactions;Laminin interactions;Syndecan interactions;ECM proteoglycans;Other semaphorin interactions;Signal transduction by L1;Localization of the PINCH-ILK-PARVIN complex to focal adhesions;CHL1 interactions;RHO GTPases Activate Formins;Interleukin-4 and Interleukin-13 signaling;Platelet Adhesion to exposed collagen;MET activates PTK2 signaling;MET interacts with TNS proteins 3690 ITGB3 False True Platelet degranulation ;Elastic fibre formation;PECAM1 interactions;Molecules associated with elastic fibres;Integrin cell surface interactions;Integrin cell surface interactions;Syndecan interactions;Syndecan interactions;ECM proteoglycans;Integrin alphaIIb beta3 signaling;GRB2:SOS provides linkage to MAPK signaling for Integrins ;p130Cas linkage to MAPK signaling for integrins;VEGFA-VEGFR2 Pathway;Signal transduction by L1;MAP2K and MAPK activation;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF 3692 EIF6 False True NA 3693 ITGB5 False True Cross-presentation of particulate exogenous antigens (phagosomes);Molecules associated with elastic fibres;Integrin cell surface interactions;Integrin cell surface interactions;Syndecan interactions;Syndecan interactions;ECM proteoglycans;Smooth Muscle Contraction 3694 ITGB6 False True Elastic fibre formation;Molecules associated with elastic fibres;Integrin cell surface interactions;ECM proteoglycans 3697 NA False True NA 3698 ITIH2 False True Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation 3702 ITK False True Generation of second messenger molecules;FCERI mediated Ca+2 mobilization;FCERI mediated Ca+2 mobilization 3704 ITPA False True Purine catabolism 3709 NA False True PLC beta mediated events;Effects of PIP2 hydrolysis;Elevation of cytosolic Ca2+ levels;DAG and IP3 signaling;Role of phospholipids in phagocytosis;FCERI mediated Ca+2 mobilization;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Ca2+ pathway;Regulation of insulin secretion;VEGFR2 mediated cell proliferation;Ion homeostasis;Ion homeostasis;CLEC7A (Dectin-1) induces NFAT activation;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 3710 ITPR3 False True PLC beta mediated events;Effects of PIP2 hydrolysis;Elevation of cytosolic Ca2+ levels;DAG and IP3 signaling;Role of phospholipids in phagocytosis;FCERI mediated Ca+2 mobilization;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Ca2+ pathway;Regulation of insulin secretion;VEGFR2 mediated cell proliferation;Ion homeostasis;Ion homeostasis;CLEC7A (Dectin-1) induces NFAT activation;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 3713 IVL False True Formation of the cornified envelope 3716 JAK1 False True Interleukin-6 signaling;Interleukin-6 signaling;MAPK3 (ERK1) activation;MAPK1 (ERK2) activation;ISG15 antiviral mechanism;Interleukin-7 signaling;Interleukin-7 signaling;Other interleukin signaling;RAF/MAP kinase cascade;Interleukin-10 signaling;Interleukin-4 and Interleukin-13 signaling;IL-6-type cytokine receptor ligand interactions;Interferon gamma signaling;Regulation of IFNG signaling;Regulation of IFNG signaling;Interleukin-20 family signaling;Interleukin-15 signaling;Interleukin-15 signaling;Interleukin-35 Signalling;Interleukin-9 signaling;Interleukin-2 signaling;Interleukin-12 signaling;Interleukin-12 signaling;Interleukin-27 signaling;Interleukin-27 signaling;Interleukin-21 signaling;Interferon alpha/beta signaling;Interleukin receptor SHC signaling;Regulation of IFNA signaling;Regulation of IFNA signaling 3717 JAK2 False True Interleukin-6 signaling;Interleukin-6 signaling;MAPK3 (ERK1) activation;MAPK1 (ERK2) activation;Prolactin receptor signaling;Prolactin receptor signaling;Signaling by SCF-KIT;Signaling by Leptin;RMTs methylate histone arginines;Interleukin-3, Interleukin-5 and GM-CSF signaling;Interleukin-3, Interleukin-5 and GM-CSF signaling;RAF activation;RAF/MAP kinase cascade;Interleukin-4 and Interleukin-13 signaling;IL-6-type cytokine receptor ligand interactions;Signaling by moderate kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF;Cyclin D associated events in G1;Interferon gamma signaling;Regulation of IFNG signaling;Regulation of IFNG signaling;Interleukin-20 family signaling;Interleukin-35 Signalling;Signaling by Erythropoietin;Interleukin-12 signaling;Interleukin-12 signaling;Interleukin-23 signaling;Interleukin-23 signaling;Interleukin-27 signaling;Interleukin-27 signaling;Erythropoietin activates Phosphoinositide-3-kinase (PI3K);Erythropoietin activates Phosphoinositide-3-kinase (PI3K);Erythropoietin activates Phospholipase C gamma (PLCG);Erythropoietin activates STAT5;Erythropoietin activates RAS;Erythropoietin activates RAS;Interleukin receptor SHC signaling;Growth hormone receptor signaling;Growth hormone receptor signaling;Factors involved in megakaryocyte development and platelet production 3720 JARID2 False True PRC2 methylates histones and DNA 3728 JUP True True Adherens junctions interactions;VEGFR2 mediated vascular permeability;Neutrophil degranulation;Keratinization;Formation of the cornified envelope 3735 KARS False True SeMet incorporation into proteins;Cytosolic tRNA aminoacylation;Mitochondrial tRNA aminoacylation 3741 KCNA5 False True Voltage gated Potassium channels 3742 KCNA6 False True Voltage gated Potassium channels 3755 KCNG1 False True Voltage gated Potassium channels 3757 KCNH2 False True Voltage gated Potassium channels;Phase 3 - rapid repolarisation 3767 KCNJ11 False True ATP sensitive Potassium channels;ABC-family proteins mediated transport;Regulation of insulin secretion;Ion homeostasis;Defective ABCC8 can cause hypoglycemias and hyperglycemias 3775 KCNK1 False True Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK);Phase 4 - resting membrane potential 3778 KCNMA1 False True Ca2+ activated K+ channels;cGMP effects 3790 KCNS3 False True Voltage gated Potassium channels;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 3799 KIF5B False True MHC class II antigen presentation;Insulin processing;RHO GTPases activate KTN1;COPI-dependent Golgi-to-ER retrograde traffic;Kinesins 3801 KIFC3 False True Association of TriC/CCT with target proteins during biosynthesis 3816 KLK1 True True Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 3827 KNG1 False True Platelet degranulation ;Intrinsic Pathway of Fibrin Clot Formation;Peptide ligand-binding receptors;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);G alpha (q) signalling events;G alpha (i) signalling events;Post-translational protein phosphorylation 3831 KLC1 False True MHC class II antigen presentation;RHO GTPases activate KTN1;COPI-dependent Golgi-to-ER retrograde traffic;Kinesins 3832 KIF11 False True MHC class II antigen presentation;COPI-dependent Golgi-to-ER retrograde traffic;Kinesins 3836 KPNA1 False True ISG15 antiviral mechanism;Integration of provirus;Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Vpr-mediated nuclear import of PICs;Activation of DNA fragmentation factor 3837 KPNB1 False True ISG15 antiviral mechanism;Regulation of cholesterol biosynthesis by SREBP (SREBF);Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Nuclear import of Rev protein;Nuclear import of Rev protein;Activation of DNA fragmentation factor;Neutrophil degranulation 3838 KPNA2 False True CaMK IV-mediated phosphorylation of CREB;ISG15 antiviral mechanism;NS1 Mediated Effects on Host Pathways;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;Sensing of DNA Double Strand Breaks;Estrogen-dependent gene expression 3839 KPNA3 False True ISG15 antiviral mechanism;NS1 Mediated Effects on Host Pathways 3840 KPNA4 False True ISG15 antiviral mechanism;NS1 Mediated Effects on Host Pathways 3848 KRT1 True True Neutrophil degranulation;Keratinization;Formation of the cornified envelope 3849 KRT2 True True Keratinization;Formation of the cornified envelope 3852 KRT5 False True Type I hemidesmosome assembly;Keratinization;Formation of the cornified envelope 3853 KRT6A True True Keratinization;Formation of the cornified envelope 3854 KRT6B True True Keratinization;Formation of the cornified envelope 3856 KRT8 False True Keratinization;Formation of the cornified envelope 3857 KRT9 False True Keratinization;Formation of the cornified envelope 3858 KRT10 True True Keratinization;Formation of the cornified envelope 3860 KRT13 True True Keratinization;Formation of the cornified envelope 3861 KRT14 False True Type I hemidesmosome assembly;Keratinization;Formation of the cornified envelope 3866 KRT15 True True Keratinization;Formation of the cornified envelope 3868 NA True False Keratinization;Formation of the cornified envelope 3872 KRT17 True True Keratinization;Formation of the cornified envelope 3875 KRT18 False True Keratinization;Formation of the cornified envelope 3880 KRT19 False True Keratinization;Formation of the cornified envelope 3881 KRT31 False True Keratinization;Formation of the cornified envelope 3884 KRT33B False True Keratinization;Formation of the cornified envelope 3887 KRT81 False True Keratinization;Formation of the cornified envelope 3892 KRT86 False True Keratinization;Formation of the cornified envelope 3895 KTN1 False True Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);RHO GTPases activate KTN1;Post-translational protein phosphorylation 3898 LAD1 False True NA 3912 LAMB1 False True Degradation of the extracellular matrix;Laminin interactions;Laminin interactions;Non-integrin membrane-ECM interactions;ECM proteoglycans;L1CAM interactions;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);MET activates PTK2 signaling;Post-translational protein phosphorylation 3916 LAMP1 True True Neutrophil degranulation 3920 LAMP2 True True Platelet degranulation ;Neutrophil degranulation 3921 RPSA True True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 3925 STMN1 False True NA 3929 LBP False True Toll Like Receptor 4 (TLR4) Cascade;Transfer of LPS from LBP carrier to CD14;Regulation of TLR by endogenous ligand;Interleukin-4 and Interleukin-13 signaling 3930 LBR False True Cholesterol biosynthesis;Regulation of MECP2 expression and activity 3932 LCK False True GPVI-mediated activation cascade;PIP3 activates AKT signaling;Signaling by SCF-KIT;Signaling by SCF-KIT;Regulation of KIT signaling;Nef and signal transduction;Nef Mediated CD4 Down-regulation;Downstream TCR signaling;Phosphorylation of CD3 and TCR zeta chains;Translocation of ZAP-70 to Immunological synapse;Generation of second messenger molecules;PECAM1 interactions;Constitutive Signaling by Aberrant PI3K in Cancer;DAP12 signaling;DAP12 signaling;CD28 co-stimulation;CD28 dependent PI3K/Akt signaling;CD28 dependent Vav1 pathway;CTLA4 inhibitory signaling;PD-1 signaling;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Interleukin-2 signaling 3933 LCN1 True True Transport of fatty acids 3934 LCN2 True True Interleukin-4 and Interleukin-13 signaling;Neutrophil degranulation;Metal sequestration by antimicrobial proteins;Iron uptake and transport;Iron uptake and transport 3937 LCP2 False True GPVI-mediated activation cascade;Generation of second messenger molecules;Generation of second messenger molecules;DAP12 signaling;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;FCERI mediated Ca+2 mobilization 3939 LDHA True True Pyruvate metabolism 3945 LDHB False True Pyruvate metabolism 3948 LDHC False True Pyruvate metabolism 3949 LDLR False True Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Chylomicron clearance;Chylomicron clearance;LDL clearance;Retinoid metabolism and transport 3956 LGALS1 False True Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation 3958 LGALS3 False True Neutrophil degranulation;Advanced glycosylation endproduct receptor signaling;RUNX1 regulates transcription of genes involved in differentiation of myeloid cells;RUNX2 regulates genes involved in differentiation of myeloid cells 3959 LGALS3BP False True Platelet degranulation 3963 LGALS7 True True NA 3978 LIG1 False True POLB-Dependent Long Patch Base Excision Repair;Early Phase of HIV Life Cycle;Processive synthesis on the C-strand of the telomere;Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha);Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta);PCNA-Dependent Long Patch Base Excision Repair;Gap-filling DNA repair synthesis and ligation in GG-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Processive synthesis on the lagging strand 3983 ABLIM1 False True DCC mediated attractive signaling 3984 LIMK1 False True Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;EPHB-mediated forward signaling;Sema3A PAK dependent Axon repulsion;Sema3A PAK dependent Axon repulsion;Sema4D induced cell migration and growth-cone collapse;RHO GTPases Activate ROCKs;RHO GTPases activate PAKs 3985 LIMK2 False True EPHB-mediated forward signaling;Sema4D induced cell migration and growth-cone collapse;RHO GTPases Activate ROCKs 3996 LLGL1 False True NA 3998 LMAN1 False True COPII-mediated vesicle transport;Cargo concentration in the ER;Transport to the Golgi and subsequent modification 4000 LMNA True True Meiotic synapsis;Clearance of Nuclear Envelope Membranes from Chromatin;Initiation of Nuclear Envelope Reformation;Breakdown of the nuclear lamina;XBP1(S) activates chaperone genes;Depolymerisation of the Nuclear Lamina;Signaling by BRAF and RAF fusions;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models 4001 LMNB1 False True Meiotic synapsis;Formation of Senescence-Associated Heterochromatin Foci (SAHF);Clearance of Nuclear Envelope Membranes from Chromatin;Initiation of Nuclear Envelope Reformation;Breakdown of the nuclear lamina;Depolymerisation of the Nuclear Lamina;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 4005 LMO2 False True RUNX1 regulates transcription of genes involved in differentiation of HSCs 4008 LMO7 False True Neddylation;Antigen processing: Ubiquitination & Proteasome degradation 4014 LOR False True Formation of the cornified envelope 4026 LPP False True NA 4033 NA False True Neutrophil degranulation 4041 LRP5 False True TCF dependent signaling in response to WNT;Negative regulation of TCF-dependent signaling by WNT ligand antagonists;Disassembly of the destruction complex and recruitment of AXIN to the membrane;Disassembly of the destruction complex and recruitment of AXIN to the membrane;Regulation of FZD by ubiquitination;Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling;RNF mutants show enhanced WNT signaling and proliferation 4047 LSS False True Cholesterol biosynthesis;Activation of gene expression by SREBF (SREBP) 4048 LTA4H False True Synthesis of Leukotrienes (LT) and Eoxins (EX);Neutrophil degranulation;Biosynthesis of D-series resolvins;Biosynthesis of protectins;Biosynthesis of E-series 18(S)-resolvins;Biosynthesis of aspirin-triggered D-series resolvins;Biosynthesis of E-series 18(R)-resolvins 4057 LTF True True Mtb iron assimilation by chelation;Neutrophil degranulation;Metal sequestration by antimicrobial proteins;Antimicrobial peptides;Amyloid fiber formation 4067 LYN False True GPVI-mediated activation cascade;Signaling by SCF-KIT;Signaling by SCF-KIT;Regulation of KIT signaling;Cell surface interactions at the vascular wall;FCGR activation;PECAM1 interactions;Fc epsilon receptor (FCERI) signaling;Fc epsilon receptor (FCERI) signaling;EPH-Ephrin signaling;Role of LAT2/NTAL/LAB on calcium mobilization;Role of LAT2/NTAL/LAB on calcium mobilization;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;FCERI mediated Ca+2 mobilization;FCERI mediated NF-kB activation;CD28 co-stimulation;CTLA4 inhibitory signaling;EPHB-mediated forward signaling;EPHB-mediated forward signaling;EPHA-mediated growth cone collapse;EPHA-mediated growth cone collapse;EPH-ephrin mediated repulsion of cells;Dectin-2 family;CD209 (DC-SIGN) signaling;CD22 mediated BCR regulation;Cyclin D associated events in G1;Platelet Adhesion to exposed collagen;Signaling by Erythropoietin;Erythropoietin activates Phosphoinositide-3-kinase (PI3K);Erythropoietin activates Phosphoinositide-3-kinase (PI3K);Erythropoietin activates Phospholipase C gamma (PLCG);Erythropoietin activates STAT5;Erythropoietin activates RAS;Erythropoietin activates RAS;Regulation of signaling by CBL;Regulation of signaling by CBL;Growth hormone receptor signaling;Growth hormone receptor signaling;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 4069 NA True False Neutrophil degranulation;Antimicrobial peptides;Amyloid fiber formation 4071 TM4SF1 False True NA 4074 M6PR False True Lysosome Vesicle Biogenesis;Retrograde transport at the Trans-Golgi-Network;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis 4082 MARCKS False True Acetylcholine regulates insulin secretion 4086 SMAD1 False True Signaling by BMP;Ub-specific processing proteases;RUNX2 regulates bone development 4088 SMAD3 False True Signaling by NODAL;Signaling by NODAL;Signaling by Activin;Downregulation of TGF-beta receptor signaling;TGF-beta receptor signaling activates SMADs;Downregulation of SMAD2/3:SMAD4 transcriptional activity;Downregulation of SMAD2/3:SMAD4 transcriptional activity;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;SMAD2/3 Phosphorylation Motif Mutants in Cancer;SMAD4 MH2 Domain Mutants in Cancer;SMAD2/3 MH2 Domain Mutants in Cancer;TGFBR1 KD Mutants in Cancer;Ub-specific processing proteases;RUNX3 regulates CDKN1A transcription;RUNX3 regulates BCL2L11 (BIM) transcription;Interleukin-37 signaling;NOTCH4 Intracellular Domain Regulates Transcription;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes;FOXO-mediated transcription of cell cycle genes;FOXO-mediated transcription of cell cycle genes 4089 SMAD4 False True Signaling by NODAL;Signaling by Activin;Signaling by BMP;TGF-beta receptor signaling activates SMADs;Downregulation of SMAD2/3:SMAD4 transcriptional activity;Downregulation of SMAD2/3:SMAD4 transcriptional activity;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;SMAD4 MH2 Domain Mutants in Cancer;SMAD2/3 MH2 Domain Mutants in Cancer;Transcriptional regulation of pluripotent stem cells;Ub-specific processing proteases;RUNX2 regulates bone development;RUNX3 regulates CDKN1A transcription;RUNX3 regulates BCL2L11 (BIM) transcription;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes;FOXO-mediated transcription of cell cycle genes;FOXO-mediated transcription of cell cycle genes 4097 MAFG False True Factors involved in megakaryocyte development and platelet production;Factors involved in megakaryocyte development and platelet production 4100 MAGEA1 False True NA 4113 MAGEB2 False True NA 4115 MAGEB4 False True NA 4118 MAL False True NA 4131 MAP1B False True NA 4133 MAP2 False True NA 4134 MAP4 False True NA 4137 MAPT False True Caspase-mediated cleavage of cytoskeletal proteins;Activation of AMPK downstream of NMDARs 4139 MARK1 False True NA 4140 MARK3 False True RAF activation;MAP2K and MAPK activation;Negative regulation of MAPK pathway;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF 4144 MAT2A False True Methylation 4145 MATK False True Downregulation of ERBB2 signaling 4149 MAX False True Transcription of E2F targets under negative control by DREAM complex;Cyclin E associated events during G1/S transition ;Cyclin A:Cdk2-associated events at S phase entry;Transcriptional Regulation by E2F6 4153 MBL2 False True Lectin pathway of complement activation;Initial triggering of complement 4168 MCF2 False True Axonal growth inhibition (RHOA activation);NRAGE signals death through JNK;Rho GTPase cycle;G alpha (12/13) signalling events 4170 MCL1 False True Interleukin-4 and Interleukin-13 signaling 4171 MCM2 False True Activation of ATR in response to replication stress;Unwinding of DNA;Assembly of the pre-replicative complex;Orc1 removal from chromatin;Activation of the pre-replicative complex;Switching of origins to a post-replicative state 4172 MCM3 False True Activation of ATR in response to replication stress;Unwinding of DNA;Assembly of the pre-replicative complex;Orc1 removal from chromatin;Activation of the pre-replicative complex;Switching of origins to a post-replicative state 4173 MCM4 False True Activation of ATR in response to replication stress;Unwinding of DNA;Assembly of the pre-replicative complex;Orc1 removal from chromatin;Activation of the pre-replicative complex;Switching of origins to a post-replicative state 4174 MCM5 False True Activation of ATR in response to replication stress;Unwinding of DNA;Assembly of the pre-replicative complex;Orc1 removal from chromatin;Activation of the pre-replicative complex;Switching of origins to a post-replicative state 4175 MCM6 False True Activation of ATR in response to replication stress;Unwinding of DNA;Assembly of the pre-replicative complex;Orc1 removal from chromatin;Activation of the pre-replicative complex;Switching of origins to a post-replicative state 4176 MCM7 False True Activation of ATR in response to replication stress;Unwinding of DNA;Assembly of the pre-replicative complex;Orc1 removal from chromatin;Activation of the pre-replicative complex;Switching of origins to a post-replicative state 4190 MDH1 False True Gluconeogenesis 4191 MDH2 True True Gluconeogenesis;Citric acid cycle (TCA cycle) 4193 MDM2 False True AKT phosphorylates targets in the cytosol;Oxidative Stress Induced Senescence;Oncogene Induced Senescence;SUMOylation of transcription factors;SUMOylation of ubiquitinylation proteins;Trafficking of AMPA receptors;Constitutive Signaling by AKT1 E17K in Cancer;Ub-specific processing proteases;Regulation of TP53 Activity through Phosphorylation;Regulation of TP53 Degradation;Regulation of TP53 Activity through Methylation;Stabilization of p53;Regulation of RUNX3 expression and activity 4194 MDM4 False True Oxidative Stress Induced Senescence;Oncogene Induced Senescence;Ub-specific processing proteases;Regulation of TP53 Activity through Phosphorylation;Regulation of TP53 Degradation;Regulation of TP53 Activity through Methylation;Stabilization of p53 4199 ME1 False True PPARA activates gene expression;Pyruvate metabolism 4204 MECP2 False True Transcriptional Regulation by MECP2;Transcriptional Regulation by MECP2;Loss of MECP2 binding ability to 5hmC-DNA;Loss of phosphorylation of MECP2 at T308;Loss of MECP2 binding ability to the NCoR/SMRT complex;Loss of MECP2 binding ability to 5mC-DNA;Regulation of MECP2 expression and activity;Regulation of MECP2 expression and activity;MECP2 regulates neuronal receptors and channels;MECP2 regulates neuronal receptors and channels;MECP2 regulates transcription of neuronal ligands;MECP2 regulates transcription factors;MECP2 regulates transcription of genes involved in GABA signaling 4205 MEF2A False True ERK/MAPK targets;CDO in myogenesis 4212 MEIS2 False True NA 4214 MAP3K1 False True MyD88:MAL(TIRAP) cascade initiated on plasma membrane;FCERI mediated MAPK activation;FCERI mediated MAPK activation;TRAF6 mediated NF-kB activation;TRAF6 mediated NF-kB activation;TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation;MyD88 cascade initiated on plasma membrane 4215 MAP3K3 False True Interleukin-1 signaling 4217 MAP3K5 False True Oxidative Stress Induced Senescence;Oxidative Stress Induced Senescence 4218 RAB8A False True Translocation of SLC2A4 (GLUT4) to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Anchoring of the basal body to the plasma membrane;VxPx cargo-targeting to cilium;TBC/RABGAPs;RAB geranylgeranylation;RAB GEFs exchange GTP for GDP on RABs 4222 MEOX1 False True NA 4223 MEOX2 False True NA 4233 MET False True PIP3 activates AKT signaling;Constitutive Signaling by Aberrant PI3K in Cancer;Sema4D mediated inhibition of cell attachment and migration;RAF/MAP kinase cascade;MET Receptor Activation;Negative regulation of MET activity;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;MET activates RAS signaling;MET activates PI3K/AKT signaling;MET activates PTPN11;MET activates PTK2 signaling;InlB-mediated entry of Listeria monocytogenes into host cell;InlB-mediated entry of Listeria monocytogenes into host cell;MET interacts with TNS proteins;MET activates RAP1 and RAC1;MET receptor recycling;MET activates STAT3;MECP2 regulates neuronal receptors and channels 4234 METTL1 False True tRNA modification in the nucleus and cytosol 4236 MFAP1 False True Molecules associated with elastic fibres 4253 CTAGE5 False True Cargo concentration in the ER 4259 MGST3 False True Glutathione conjugation;Aflatoxin activation and detoxification 4282 MIF False True Cell surface interactions at the vascular wall;Neutrophil degranulation;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 4284 MIP False True Passive transport by Aquaporins 4287 ATXN3 False True Josephin domain DUBs;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 4288 MKI67 False True NA 4289 MKLN1 False True NA 4292 MLH1 False True Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha);Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta);Defective Mismatch Repair Associated With MLH1;Defective Mismatch Repair Associated With PMS2;TP53 Regulates Transcription of DNA Repair Genes;Meiotic recombination 4293 MAP3K9 False True NA 4301 MLLT4 False True Adherens junctions interactions;Adherens junctions interactions 4303 FOXO4 False True AKT phosphorylates targets in the nucleus;Constitutive Signaling by AKT1 E17K in Cancer;Ub-specific processing proteases;Regulation of localization of FOXO transcription factors;FOXO-mediated transcription of cell death genes;FOXO-mediated transcription of cell death genes;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes;Regulation of FOXO transcriptional activity by acetylation;FOXO-mediated transcription of cell cycle genes;FOXO-mediated transcription of cell cycle genes 4306 NR3C2 False True HSP90 chaperone cycle for steroid hormone receptors (SHR);Nuclear Receptor transcription pathway;SUMOylation of intracellular receptors 4311 MME False True Metabolism of Angiotensinogen to Angiotensins;Neutrophil degranulation 4313 MMP2 False True Collagen degradation;Collagen degradation;Degradation of the extracellular matrix;Degradation of the extracellular matrix;Activation of Matrix Metalloproteinases;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);EPH-ephrin mediated repulsion of cells;Interleukin-4 and Interleukin-13 signaling 4329 ALDH6A1 False True Branched-chain amino acid catabolism 4342 MOS False True NA 4351 MPI False True Defective MPI causes MPI-CDG (CDG-1b);Synthesis of GDP-mannose 4361 MRE11A False True Cytosolic sensors of pathogen-associated DNA ;DNA Damage/Telomere Stress Induced Senescence;IRF3-mediated induction of type I IFN;HDR through Single Strand Annealing (SSA);HDR through MMEJ (alt-NHEJ);HDR through Homologous Recombination (HRR);Sensing of DNA Double Strand Breaks;Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA);Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Resolution of D-loop Structures through Holliday Junction Intermediates;Nonhomologous End-Joining (NHEJ);Homologous DNA Pairing and Strand Exchange;Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;Regulation of TP53 Activity through Phosphorylation;G2/M DNA damage checkpoint;Meiotic recombination 4430 NA False True NA 4478 MSN False True Recycling pathway of L1;Recycling pathway of L1;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 4481 MSR1 False True Scavenging by Class A Receptors;Scavenging by Class A Receptors 4496 NA False True Metallothioneins bind metals 4507 MTAP False True Methionine salvage pathway;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 4513 COX2 False True TP53 Regulates Metabolic Genes;Respiratory electron transport 4522 MTHFD1 False True Metabolism of folate and pterines 4528 NA False True Mitochondrial translation initiation 4580 MTX1 False True Mitochondrial protein import;Cristae formation 4586 MUC5AC False True Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC);Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS);Defective GALNT12 causes colorectal cancer 1 (CRCS1);Dectin-2 family;O-linked glycosylation of mucins;Termination of O-glycan biosynthesis 4589 NA True False Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC);Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS);Defective GALNT12 causes colorectal cancer 1 (CRCS1);Dectin-2 family;O-linked glycosylation of mucins;Termination of O-glycan biosynthesis 4591 TRIM37 False True Antigen processing: Ubiquitination & Proteasome degradation 4593 MUSK False True ECM proteoglycans 4595 MUTYH False True Recognition and association of DNA glycosylase with site containing an affected purine;Cleavage of the damaged purine;Displacement of DNA glycosylase by APEX1;Defective MUTYH substrate binding;Defective MUTYH substrate processing 4597 MVD False True Cholesterol biosynthesis;Activation of gene expression by SREBF (SREBP);Synthesis of Dolichyl-phosphate 4598 MVK False True Cholesterol biosynthesis;Activation of gene expression by SREBF (SREBP) 4602 MYB False True RUNX1 regulates transcription of genes involved in differentiation of HSCs;Estrogen-dependent gene expression;Factors involved in megakaryocyte development and platelet production 4607 MYBPC3 False True Striated Muscle Contraction 4609 MYC False True Transcription of E2F targets under negative control by DREAM complex;NOTCH1 Intracellular Domain Regulates Transcription;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Binding of TCF/LEF:CTNNB1 to target gene promoters;MAPK6/MAPK4 signaling;Ub-specific processing proteases;Interleukin-4 and Interleukin-13 signaling;Cyclin E associated events during G1/S transition ;Cyclin A:Cdk2-associated events at S phase entry;TFAP2 (AP-2) family regulates transcription of cell cycle factors;RUNX3 regulates WNT signaling;Estrogen-dependent gene expression 4619 MYH1 False True NA 4627 MYH9 True True Translocation of SLC2A4 (GLUT4) to the plasma membrane;Regulation of actin dynamics for phagocytic cup formation;EPHA-mediated growth cone collapse;Sema4D induced cell migration and growth-cone collapse;RHO GTPases activate PKNs;RHO GTPases activate CIT;RHO GTPases Activate ROCKs;RHO GTPases activate PAKs;RHO GTPases activate PAKs 4628 MYH10 False True EPHA-mediated growth cone collapse;Sema4D induced cell migration and growth-cone collapse;RHO GTPases activate PKNs;RHO GTPases activate CIT;RHO GTPases Activate ROCKs;RHO GTPases activate PAKs;RHO GTPases activate PAKs 4629 MYH11 False True EPHA-mediated growth cone collapse;Sema4D induced cell migration and growth-cone collapse;Smooth Muscle Contraction;RHO GTPases activate PKNs;RHO GTPases activate CIT;RHO GTPases Activate ROCKs;RHO GTPases activate PAKs;RHO GTPases activate PAKs 4633 MYL2 False True Striated Muscle Contraction 4635 MYL4 False True Striated Muscle Contraction 4637 MYL6 False True EPHA-mediated growth cone collapse;Sema4D induced cell migration and growth-cone collapse;Smooth Muscle Contraction;RHO GTPases activate PKNs;RHO GTPases activate CIT;RHO GTPases Activate ROCKs;RHO GTPases activate PAKs;RHO GTPases activate PAKs 4638 MYLK False True Smooth Muscle Contraction;RHO GTPases activate PAKs;RHO GTPases activate PAKs 4641 MYO1C False True Translocation of SLC2A4 (GLUT4) to the plasma membrane;Regulation of actin dynamics for phagocytic cup formation;B-WICH complex positively regulates rRNA expression 4643 MYO1E False True NA 4644 MYO5A False True Translocation of SLC2A4 (GLUT4) to the plasma membrane;Regulation of actin dynamics for phagocytic cup formation;Insulin processing 4645 MYO5B False True Vasopressin regulates renal water homeostasis via Aquaporins 4646 MYO6 False True Gap junction degradation;Trafficking of AMPA receptors 4654 MYOD1 False True CDO in myogenesis;CDO in myogenesis 4659 PPP1R12A False True Regulation of PLK1 Activity at G2/M Transition;RHO GTPases activate PKNs;RHO GTPases activate PKNs;RHO GTPases activate CIT;RHO GTPases Activate ROCKs;RHO GTPases activate PAKs;RHO GTPases activate PAKs 4660 PPP1R12B False True Regulation of PLK1 Activity at G2/M Transition;RHO GTPases activate PKNs;RHO GTPases activate PKNs;RHO GTPases activate CIT;RHO GTPases Activate ROCKs;RHO GTPases activate PAKs;RHO GTPases activate PAKs 4664 NAB1 False True NA 4665 NAB2 False True NA 4666 NACA False True NA 4670 HNRNPM False True FGFR2 alternative splicing;mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA 4673 NAP1L1 False True NA 4676 NAP1L4 False True NA 4677 NARS False True Cytosolic tRNA aminoacylation 4686 NCBP1 False True Cleavage of Growing Transcript in the Termination Region ;SLBP independent Processing of Histone Pre-mRNAs;Formation of RNA Pol II elongation complex ;Formation of the Early Elongation Complex;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Formation of HIV elongation complex in the absence of HIV Tat;Formation of the HIV-1 Early Elongation Complex;Formation of HIV-1 elongation complex containing HIV-1 Tat;Abortive elongation of HIV-1 transcript in the absence of Tat;snRNP Assembly;RNA Polymerase II Pre-transcription Events;FGFR2 alternative splicing;RNA polymerase II transcribes snRNA genes;mRNA Capping;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;mRNA 3'-end processing;Processing of Capped Intron-Containing Pre-mRNA;SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs;Processing of Intronless Pre-mRNAs;Signaling by FGFR2 IIIa TM;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 4689 NCF4 False True ROS, RNS production in phagocytes;Cross-presentation of particulate exogenous antigens (phagosomes);Detoxification of Reactive Oxygen Species;VEGFA-VEGFR2 Pathway;RHO GTPases Activate NADPH Oxidases 4690 NCK1 False True Downstream signal transduction;Generation of second messenger molecules;Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;Nephrin family interactions;DCC mediated attractive signaling;DCC mediated attractive signaling;Activation of RAC1;VEGFA-VEGFR2 Pathway;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 4691 NCL False True Major pathway of rRNA processing in the nucleolus and cytosol 4702 NDUFA8 False True Respiratory electron transport;Complex I biogenesis 4704 NDUFA9 False True Respiratory electron transport;Complex I biogenesis 4706 NDUFAB1 False True Glyoxylate metabolism and glycine degradation;Respiratory electron transport;Complex I biogenesis;Mitochondrial Fatty Acid Beta-Oxidation 4707 NDUFB1 False True Respiratory electron transport;Complex I biogenesis 4708 NDUFB2 False True Respiratory electron transport;Complex I biogenesis 4713 NDUFB7 False True Respiratory electron transport;Complex I biogenesis 4723 NDUFV1 False True Respiratory electron transport;Complex I biogenesis 4724 NDUFS4 False True Respiratory electron transport;Complex I biogenesis 4733 DRG1 False True NA 4734 NEDD4 False True ISG15 antiviral mechanism;Downregulation of ERBB4 signaling;Regulation of PTEN localization;Regulation of PTEN stability and activity;Antigen processing: Ubiquitination & Proteasome degradation 4735 SEPT2 False True Anchoring of the basal body to the plasma membrane 4736 RPL10A False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 4741 NEFM False True NA 4747 NEFL False True Unblocking of NMDA receptors, glutamate binding and activation;Unblocking of NMDA receptors, glutamate binding and activation;Ras activation upon Ca2+ influx through NMDA receptor;RAF/MAP kinase cascade;Negative regulation of NMDA receptor-mediated neuronal transmission;Long-term potentiation 4758 NEU1 False True Glycosphingolipid metabolism;Sialic acid metabolism;Defective NEU1 causes sialidosis;Neutrophil degranulation 4775 NFATC3 False True Calcineurin activates NFAT;Calcineurin activates NFAT;FCERI mediated Ca+2 mobilization;CLEC7A (Dectin-1) induces NFAT activation 4776 NFATC4 False True NA 4779 NFE2L1 False True NA 4782 NFIC False True RNA Polymerase III Transcription Termination;RNA Polymerase III Abortive And Retractive Initiation 4790 NFKB1 False True Activation of NF-kappaB in B cells;RIP-mediated NFkB activation via ZBP1;Regulated proteolysis of p75NTR;Downstream TCR signaling;NF-kB is activated and signals survival;Senescence-Associated Secretory Phenotype (SASP);FCERI mediated NF-kB activation;DEx/H-box helicases activate type I IFN and inflammatory cytokines production ;PKMTs methylate histone lysines;Transcriptional regulation of white adipocyte differentiation;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;Interleukin-1 processing;IkBA variant leads to EDA-ID;CLEC7A (Dectin-1) signaling;CD209 (DC-SIGN) signaling;CLEC7A/inflammasome pathway;MAP3K8 (TPL2)-dependent MAPK1/3 activation;Neutrophil degranulation;The NLRP3 inflammasome;Interleukin-1 signaling;TRAF6 mediated NF-kB activation 4792 NFKBIA False True Activation of NF-kappaB in B cells;RIP-mediated NFkB activation via ZBP1;Downstream TCR signaling;NF-kB is activated and signals survival;FCERI mediated NF-kB activation;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;SUMOylation of immune response proteins;IkBA variant leads to EDA-ID;CLEC7A (Dectin-1) signaling;Ub-specific processing proteases;Interleukin-1 signaling;TRAF6 mediated NF-kB activation 4794 NFKBIE False True Activation of NF-kappaB in B cells 4798 NFRKB False True UCH proteinases;DNA Damage Recognition in GG-NER 4800 NFYA False True PPARA activates gene expression;Activation of gene expression by SREBF (SREBP);Activation of gene expression by SREBF (SREBP);ATF4 activates genes;ATF6 (ATF6-alpha) activates chaperone genes;FOXO-mediated transcription of cell death genes 4801 NFYB False True PPARA activates gene expression;Activation of gene expression by SREBF (SREBP);Activation of gene expression by SREBF (SREBP);ATF4 activates genes;ATF6 (ATF6-alpha) activates chaperone genes;FOXO-mediated transcription of cell death genes 4802 NFYC False True PPARA activates gene expression;Activation of gene expression by SREBF (SREBP);Activation of gene expression by SREBF (SREBP);ATF4 activates genes;ATF6 (ATF6-alpha) activates chaperone genes;FOXO-mediated transcription of cell death genes 4815 NINJ2 False True NA 4817 NIT1 False True NA 4818 NKG7 False True NA 4830 NME1 False True Interconversion of nucleotide di- and triphosphates 4831 NME2 False True Interconversion of nucleotide di- and triphosphates;Neutrophil degranulation 4839 NOP2 False True rRNA modification in the nucleus and cytosol;TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation 4841 NONO False True NA 4843 NOS2 False True ROS, RNS production in phagocytes;Nitric oxide stimulates guanylate cyclase;Interleukin-4 and Interleukin-13 signaling;Peroxisomal protein import;Peroxisomal protein import 4846 NOS3 False True ROS, RNS production in phagocytes;Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation;eNOS activation;NOSTRIN mediated eNOS trafficking;NOSIP mediated eNOS trafficking;Nitric oxide stimulates guanylate cyclase;VEGFR2 mediated vascular permeability 4848 CNOT2 False True Deadenylation of mRNA;TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 4849 CNOT3 False True Deadenylation of mRNA;TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 4860 PNP True True Neutrophil degranulation;Purine salvage;Purine catabolism 4862 NPAS2 False True BMAL1:CLOCK,NPAS2 activates circadian gene expression;BMAL1:CLOCK,NPAS2 activates circadian gene expression;PPARA activates gene expression;PPARA activates gene expression;Circadian Clock;Circadian Clock 4863 NPAT False True NA 4868 NPHS1 False True Nephrin family interactions;Nephrin family interactions 4869 NPM1 False True Nuclear import of Rev protein;Nuclear import of Rev protein;SUMOylation of transcription cofactors;Deposition of new CENPA-containing nucleosomes at the centromere;TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain;TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation 4898 NRD1 False True NA 4904 YBX1 False True mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;Noncanonical activation of NOTCH3 4914 NTRK1 False True PLC-gamma1 signalling;Signalling to RAS;Frs2-mediated activation;Frs2-mediated activation;ARMS-mediated activation;ARMS-mediated activation;Retrograde neurotrophin signalling;Retrograde neurotrophin signalling;NGF-independant TRKA activation;TRKA activation by NGF;TRKA activation by NGF;Signalling to p38 via RIT and RIN;PI3K/AKT activation;PI3K/AKT activation;Signalling to STAT3 4915 NTRK2 False True NGF-independant TRKA activation;BDNF activates NTRK2 (TRKB) signaling;NTF3 activates NTRK2 (TRKB) signaling;NTF4 activates NTRK2 (TRKB) signaling;Activated NTRK2 signals through RAS;Activated NTRK2 signals through PLCG1;Activated NTRK2 signals through PLCG1;Activated NTRK2 signals through PI3K;Activated NTRK2 signals through FRS2 and FRS3;Activated NTRK2 signals through FRS2 and FRS3;Activated NTRK2 signals through FYN;NTRK2 activates RAC1;NTRK2 activates RAC1;Activated NTRK2 signals through CDK5 4916 NTRK3 False True Receptor-type tyrosine-protein phosphatases;NTF3 activates NTRK3 signaling;NTF3 activates NTRK3 signaling;Signaling by NTRK3 (TRKC);Activated NTRK3 signals through PLCG1;Activated NTRK3 signals through PLCG1;Activated NTRK3 signals through RAS;Activated NTRK3 signals through PI3K;Activated NTRK3 signals through PI3K;NTRK3 as a dependence receptor 4919 ROR1 False True WNT5A-dependent internalization of FZD2, FZD5 and ROR2 4920 ROR2 False True PCP/CE pathway;WNT5A-dependent internalization of FZD2, FZD5 and ROR2 4921 DDR2 False True Non-integrin membrane-ECM interactions 4924 NUCB1 False True Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation 4926 NUMA1 False True Recruitment of NuMA to mitotic centrosomes;Mitotic Prophase 4928 NUP98 False True ISG15 antiviral mechanism;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Rev-mediated nuclear export of HIV RNA;Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Viral Messenger RNA Synthesis;NEP/NS2 Interacts with the Cellular Export Machinery;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;snRNP Assembly;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;SUMOylation of DNA damage response and repair proteins;SUMOylation of ubiquitinylation proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;SUMOylation of SUMOylation proteins;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins;Transcriptional regulation by small RNAs;RHO GTPases Activate Formins;tRNA processing in the nucleus;Mitotic Prometaphase 4931 NVL False True NA 4942 OAT False True Amino acid synthesis and interconversion (transamination) 4967 OGDH False True Glyoxylate metabolism and glycine degradation;Lysine catabolism;Citric acid cycle (TCA cycle) 4976 OPA1 False True Regulation of Apoptosis 4995 NA False True Olfactory Signaling Pathway 4999 ORC2 False True E2F-enabled inhibition of pre-replication complex formation;Activation of ATR in response to replication stress;Assembly of the ORC complex at the origin of replication;CDC6 association with the ORC:origin complex;CDT1 association with the CDC6:ORC:origin complex;Assembly of the pre-replicative complex;Orc1 removal from chromatin;Activation of the pre-replicative complex 5000 ORC4 False True E2F-enabled inhibition of pre-replication complex formation;Activation of ATR in response to replication stress;Assembly of the ORC complex at the origin of replication;CDC6 association with the ORC:origin complex;CDT1 association with the CDC6:ORC:origin complex;Assembly of the pre-replicative complex;Orc1 removal from chromatin;Activation of the pre-replicative complex 5001 ORC5 False True E2F-enabled inhibition of pre-replication complex formation;Activation of ATR in response to replication stress;Assembly of the ORC complex at the origin of replication;CDC6 association with the ORC:origin complex;CDT1 association with the CDC6:ORC:origin complex;Assembly of the pre-replicative complex;Orc1 removal from chromatin;Activation of the pre-replicative complex 5004 ORM1 True True Platelet degranulation ;Neutrophil degranulation 5005 ORM2 False True Platelet degranulation ;Neutrophil degranulation 5019 OXCT1 False True Utilization of Ketone Bodies 5034 P4HB False True Collagen biosynthesis and modifying enzymes;Detoxification of Reactive Oxygen Species;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Hedgehog ligand biogenesis;VLDL assembly;Post-translational protein phosphorylation;Chylomicron assembly;Interleukin-12 signaling;Interleukin-23 signaling 5036 PA2G4 False True Neutrophil degranulation 5037 PEBP1 False True MAP2K and MAPK activation;Negative regulation of MAPK pathway;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF 5042 PABPC3 False True NA 5048 PAFAH1B1 False True Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;RHO GTPases Activate Formins;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;AURKA Activation by TPX2 5049 PAFAH1B2 False True Neutrophil degranulation;COPI-independent Golgi-to-ER retrograde traffic 5052 PRDX1 True True Detoxification of Reactive Oxygen Species;TP53 Regulates Metabolic Genes;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models 5054 SERPINE1 False True Platelet degranulation ;BMAL1:CLOCK,NPAS2 activates circadian gene expression;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;ECM proteoglycans;Dissolution of Fibrin Clot 5062 PAK2 False True Nef and signal transduction;Generation of second messenger molecules;Regulation of PAK-2p34 activity by PS-GAP/RHG10;Regulation of activated PAK-2p34 by proteasome mediated degradation;Stimulation of the cell death response by PAK-2p34;FCERI mediated MAPK activation;FCERI mediated MAPK activation;CD28 dependent Vav1 pathway;Ephrin signaling;Sema3A PAK dependent Axon repulsion;Activation of RAC1;VEGFA-VEGFR2 Pathway;Smooth Muscle Contraction;VEGFR2 mediated vascular permeability;CD209 (DC-SIGN) signaling;RHO GTPases activate PAKs;RHO GTPases activate PAKs;MAPK6/MAPK4 signaling;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 5071 PARK2 False True Pink/Parkin Mediated Mitophagy;Josephin domain DUBs;Amyloid fiber formation;Antigen processing: Ubiquitination & Proteasome degradation 5074 PAWR False True NA 5093 PCBP1 False True mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA 5094 PCBP2 False True mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA;Negative regulators of DDX58/IFIH1 signaling 5097 PCDH1 False True NA 5108 PCM1 False True Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;AURKA Activation by TPX2 5110 PCMT1 False True Protein repair 5111 PCNA False True Translesion synthesis by REV1;Recognition of DNA damage by PCNA-containing replication complex;Translesion Synthesis by POLH;Transcription of E2F targets under negative control by DREAM complex;Polymerase switching on the C-strand of the telomere;Processive synthesis on the C-strand of the telomere;Telomere C-strand (Lagging Strand) Synthesis;Removal of the Flap Intermediate from the C-strand;SUMOylation of DNA replication proteins;Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha);Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta);Activation of E2F1 target genes at G1/S;PCNA-Dependent Long Patch Base Excision Repair;Translesion synthesis by POLK;Translesion synthesis by POLI;Termination of translesion DNA synthesis;HDR through Homologous Recombination (HRR);Gap-filling DNA repair synthesis and ligation in GG-NER;Dual Incision in GG-NER;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest;Polymerase switching;Removal of the Flap Intermediate;Processive synthesis on the lagging strand;E3 ubiquitin ligases ubiquitinate target proteins 5116 PCNT False True Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;AURKA Activation by TPX2 5127 CDK16 False True NA 5129 CDK18 False True NA 5139 PDE3A False True cGMP effects;G alpha (s) signalling events 5142 PDE4B False True DARPP-32 events;G alpha (s) signalling events 5159 PDGFRB False True PIP3 activates AKT signaling;Downstream signal transduction;Signaling by PDGF;Constitutive Signaling by Aberrant PI3K in Cancer;RAF/MAP kinase cascade;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 5160 PDHA1 False True Regulation of pyruvate dehydrogenase (PDH) complex;Glyoxylate metabolism and glycine degradation;Signaling by Retinoic Acid;Pyruvate metabolism 5162 PDHB False True Regulation of pyruvate dehydrogenase (PDH) complex;Glyoxylate metabolism and glycine degradation;Signaling by Retinoic Acid;Pyruvate metabolism 5168 ENPP2 False True Vitamin B5 (pantothenate) metabolism 5173 PDYN False True Opioid Signalling;G-protein activation;Peptide ligand-binding receptors;G alpha (i) signalling events 5178 PEG3 False True NA 5184 PEPD False True NA 5197 NA False True Common Pathway of Fibrin Clot Formation;Cell surface interactions at the vascular wall 5198 PFAS False True Purine ribonucleoside monophosphate biosynthesis 5202 PFDN2 False True Prefoldin mediated transfer of substrate to CCT/TriC 5208 PFKFB2 False True Glycolysis 5213 PFKM False True Glycolysis 5214 PFKP False True Glycolysis 5216 PFN1 False True Platelet degranulation ;Signaling by ROBO receptors;PCP/CE pathway;RHO GTPases Activate Formins;RHO GTPases Activate Formins 5217 PFN2 False True Signaling by ROBO receptors;RHO GTPases Activate Formins;RHO GTPases Activate Formins 5218 CDK14 False True NA 5223 PGAM1 False True Neutrophil degranulation;Glycolysis;Gluconeogenesis 5224 PGAM2 False True Glycolysis;Gluconeogenesis 5226 PGD False True Pentose phosphate pathway 5230 PGK1 True True Glycolysis;Gluconeogenesis 5232 PGK2 False True Glycolysis;Gluconeogenesis 5236 PGM1 False True Glycogen synthesis;Defective PGM1 causes PGM1-CDG (CDG1t);Neutrophil degranulation;Glycogen breakdown (glycogenolysis);Galactose catabolism 5239 PGM5 False True NA 5245 PHB False True RAF activation;Signaling by moderate kinase activity BRAF mutants;Signaling by RAS mutants;Paradoxical activation of RAF signaling by kinase inactive BRAF;Processing of SMDT1 5250 SLC25A3 False True NA 5255 PHKA1 False True Glycogen breakdown (glycogenolysis);Glycogen breakdown (glycogenolysis) 5265 SERPINA1 True True Platelet degranulation ;COPII-mediated vesicle transport;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Cargo concentration in the ER;Neutrophil degranulation;Post-translational protein phosphorylation 5266 PI3 False True Antimicrobial peptides;Formation of the cornified envelope 5267 SERPINA4 False True Platelet degranulation 5268 SERPINB5 True True NA 5270 SERPINE2 False True Intrinsic Pathway of Fibrin Clot Formation;Common Pathway of Fibrin Clot Formation;Dissolution of Fibrin Clot 5275 SERPINB13 True True RUNX1 regulates transcription of genes involved in differentiation of keratinocytes 5277 PIGA False True Synthesis of glycosylphosphatidylinositol (GPI) 5284 NA True False Neutrophil degranulation 5286 PIK3C2A False True Synthesis of PIPs at the plasma membrane;Synthesis of PIPs at the Golgi membrane;Synthesis of PIPs at the early endosome membrane;Synthesis of PIPs at the late endosome membrane;Golgi Associated Vesicle Biogenesis;Clathrin-mediated endocytosis 5287 PIK3C2B False True Synthesis of PIPs at the plasma membrane 5289 PIK3C3 False True PI3K Cascade;Macroautophagy;Synthesis of PIPs at the Golgi membrane;Synthesis of PIPs at the early endosome membrane;Synthesis of PIPs at the late endosome membrane;Toll Like Receptor 9 (TLR9) Cascade;RHO GTPases Activate NADPH Oxidases 5290 PIK3CA False True PI3K Cascade;IRS-mediated signalling;GPVI-mediated activation cascade;Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants;PI3K events in ERBB4 signaling;PIP3 activates AKT signaling;Signaling by SCF-KIT;Synthesis of PIPs at the plasma membrane;GAB1 signalosome;Signaling by cytosolic FGFR1 fusion mutants;Downstream signal transduction;PI3K events in ERBB2 signaling;PI3K/AKT activation;Downstream TCR signaling;Role of phospholipids in phagocytosis;Tie2 Signaling;Constitutive Signaling by Aberrant PI3K in Cancer;DAP12 signaling;Role of LAT2/NTAL/LAB on calcium mobilization;Nephrin family interactions;Costimulation by the CD28 family;CD28 dependent PI3K/Akt signaling;G alpha (q) signalling events;VEGFA-VEGFR2 Pathway;VEGFA-VEGFR2 Pathway;Interleukin-3, Interleukin-5 and GM-CSF signaling;Constitutive Signaling by EGFRvIII;PI-3K cascade:FGFR1;PI-3K cascade:FGFR2;PI-3K cascade:FGFR3;PI-3K cascade:FGFR4;Signaling by FGFR2 in disease;Signaling by FGFR4 in disease;Signaling by FGFR1 in disease;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;MET activates PI3K/AKT signaling;Signaling by FGFR3 fusions in cancer;Signaling by FGFR3 point mutants in cancer;RET signaling;Erythropoietin activates Phosphoinositide-3-kinase (PI3K);Erythropoietin activates Phosphoinositide-3-kinase (PI3K);Activated NTRK2 signals through PI3K;Interleukin receptor SHC signaling;Regulation of signaling by CBL;Regulation of signaling by CBL;Activated NTRK3 signals through PI3K 5292 PIM1 False True Interleukin-4 and Interleukin-13 signaling 5296 PIK3R2 False True PI3K Cascade;IRS-mediated signalling;GPVI-mediated activation cascade;PIP3 activates AKT signaling;Interleukin-7 signaling;Interleukin-7 signaling;Signaling by SCF-KIT;Synthesis of PIPs at the plasma membrane;Downstream signal transduction;Rho GTPase cycle;PI3K/AKT activation;Downstream TCR signaling;Role of phospholipids in phagocytosis;Tie2 Signaling;Constitutive Signaling by Aberrant PI3K in Cancer;DAP12 signaling;Role of LAT2/NTAL/LAB on calcium mobilization;Nephrin family interactions;Costimulation by the CD28 family;CD28 dependent PI3K/Akt signaling;G alpha (q) signalling events;VEGFA-VEGFR2 Pathway;VEGFA-VEGFR2 Pathway;Interleukin-3, Interleukin-5 and GM-CSF signaling;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;RET signaling;Interleukin receptor SHC signaling;Regulation of signaling by CBL;Regulation of signaling by CBL 5298 PI4KB False True Synthesis of PIPs at the Golgi membrane 5300 PIN1 False True ISG15 antiviral mechanism;RHO GTPases Activate NADPH Oxidases;Regulation of TP53 Activity through Phosphorylation;PI5P Regulates TP53 Acetylation;Negative regulators of DDX58/IFIH1 signaling 5304 NA True False Miscellaneous transport and binding events 5306 PITPNA False True Role of second messengers in netrin-1 signaling;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 5311 PKD2 False True VxPx cargo-targeting to cilium;VxPx cargo-targeting to cilium 5315 PKM True True Neutrophil degranulation;Glycolysis 5317 PKP1 False True Apoptotic cleavage of cell adhesion proteins;Neutrophil degranulation;Keratinization;Formation of the cornified envelope 5318 PKP2 False True Keratinization;Formation of the cornified envelope 5321 PLA2G4A False True phospho-PLA2 pathway;Acyl chain remodelling of PC;Acyl chain remodeling of CL;Acyl chain remodelling of PS;Acyl chain remodelling of PE;Acyl chain remodelling of PI;Acyl chain remodelling of PG;Hydrolysis of LPC;Synthesis of PA;Arachidonic acid metabolism;ADP signalling through P2Y purinoceptor 1;Platelet sensitization by LDL;COPI-independent Golgi-to-ER retrograde traffic 5324 NA False True NA 5327 PLAT False True Signaling by PDGF;Dissolution of Fibrin Clot 5339 PLEC True True Assembly of collagen fibrils and other multimeric structures;Caspase-mediated cleavage of cytoskeletal proteins;Type I hemidesmosome assembly 5340 PLG False True Platelet degranulation ;Degradation of the extracellular matrix;Degradation of the extracellular matrix;Activation of Matrix Metalloproteinases;Signaling by PDGF;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Dissolution of Fibrin Clot 5347 PLK1 False True Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Polo-like kinase mediated events;Golgi Cisternae Pericentriolar Stack Reorganization;Golgi Cisternae Pericentriolar Stack Reorganization;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Phosphorylation of the APC/C;Phosphorylation of Emi1;Condensation of Prophase Chromosomes;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;Regulation of PLK1 Activity at G2/M Transition;Activation of NIMA Kinases NEK9, NEK6, NEK7;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;RHO GTPases Activate Formins;Mitotic Prometaphase;Mitotic Metaphase/Anaphase Transition;Mitotic Telophase/Cytokinesis;Cyclin A/B1/B2 associated events during G2/M transition;The role of GTSE1 in G2/M progression after G2 checkpoint;AURKA Activation by TPX2 5349 FXYD3 False True Ion homeostasis;Ion transport by P-type ATPases 5354 PLP1 False True NA 5355 PLP2 False True NA 5357 NA False True NA 5371 PML False True SUMOylation of DNA damage response and repair proteins;SUMOylation of ubiquitinylation proteins;Regulation of TP53 Activity through Acetylation;Interferon gamma signaling;Regulation of RUNX1 Expression and Activity;Regulation of PTEN localization 5375 PMP2 False True NA 5376 PMP22 False True NA 5395 PMS2 False True Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha);Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta);Defective Mismatch Repair Associated With MLH1;Defective Mismatch Repair Associated With PMS2;TP53 Regulates Transcription of DNA Repair Genes 5406 PNLIP False True Digestion of dietary lipid;Retinoid metabolism and transport 5407 PNLIPRP1 False True Digestion of dietary lipid 5422 POLA1 False True Inhibition of replication initiation of damaged DNA by RB1/E2F1;Polymerase switching on the C-strand of the telomere;Telomere C-strand synthesis initiation;Activation of E2F1 target genes at G1/S;DNA replication initiation;Activation of the pre-replicative complex;Polymerase switching;Removal of the Flap Intermediate;Processive synthesis on the lagging strand 5427 POLE2 False True Recognition of DNA damage by PCNA-containing replication complex;Telomere C-strand synthesis initiation;PCNA-Dependent Long Patch Base Excision Repair;Termination of translesion DNA synthesis;HDR through Homologous Recombination (HRR);Gap-filling DNA repair synthesis and ligation in GG-NER;Dual Incision in GG-NER;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;DNA replication initiation;Activation of the pre-replicative complex 5429 POLH False True Translesion Synthesis by POLH;Termination of translesion DNA synthesis;HDR through Homologous Recombination (HRR) 5433 POLR2D False True Formation of RNA Pol II elongation complex ;Formation of the Early Elongation Complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of the HIV-1 Early Elongation Complex;RNA Pol II CTD phosphorylation and interaction with CE during HIV infection;HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;Formation of HIV-1 elongation complex containing HIV-1 Tat;Formation of HIV-1 elongation complex containing HIV-1 Tat;Pausing and recovery of Tat-mediated HIV elongation;Abortive elongation of HIV-1 transcript in the absence of Tat;Tat-mediated HIV elongation arrest and recovery;Tat-mediated elongation of the HIV-1 transcript;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;Viral Messenger RNA Synthesis;MicroRNA (miRNA) biogenesis;Transcriptional regulation of pluripotent stem cells;Transcriptional regulation by small RNAs;PIWI-interacting RNA (piRNA) biogenesis;Activation of anterior HOX genes in hindbrain development during early embryogenesis;RNA Polymerase II Pre-transcription Events;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;TP53 Regulates Transcription of DNA Repair Genes;FGFR2 alternative splicing;RNA polymerase II transcribes snRNA genes;RNA polymerase II transcribes snRNA genes;mRNA Capping;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;Processing of Capped Intron-Containing Pre-mRNA;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Elongation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Pol II CTD phosphorylation and interaction with CE;Signaling by FGFR2 IIIa TM;Estrogen-dependent gene expression 5434 POLR2E False True Formation of RNA Pol II elongation complex ;Formation of the Early Elongation Complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of the HIV-1 Early Elongation Complex;RNA Pol II CTD phosphorylation and interaction with CE during HIV infection;HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;Formation of HIV-1 elongation complex containing HIV-1 Tat;Formation of HIV-1 elongation complex containing HIV-1 Tat;Pausing and recovery of Tat-mediated HIV elongation;Abortive elongation of HIV-1 transcript in the absence of Tat;Tat-mediated HIV elongation arrest and recovery;Tat-mediated elongation of the HIV-1 transcript;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;Viral Messenger RNA Synthesis;Cytosolic sensors of pathogen-associated DNA ;MicroRNA (miRNA) biogenesis;NoRC negatively regulates rRNA expression;Transcriptional regulation of pluripotent stem cells;B-WICH complex positively regulates rRNA expression;Transcriptional regulation by small RNAs;PIWI-interacting RNA (piRNA) biogenesis;Activation of anterior HOX genes in hindbrain development during early embryogenesis;RNA Polymerase II Pre-transcription Events;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;TP53 Regulates Transcription of DNA Repair Genes;FGFR2 alternative splicing;RNA polymerase II transcribes snRNA genes;RNA polymerase II transcribes snRNA genes;mRNA Capping;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;Processing of Capped Intron-Containing Pre-mRNA;RNA Polymerase I Transcription Initiation;RNA Polymerase I Transcription Initiation;RNA Polymerase I Promoter Escape;RNA Polymerase II Promoter Escape;RNA Polymerase I Chain Elongation;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase III Chain Elongation;RNA Polymerase I Transcription Termination;RNA Polymerase III Transcription Termination;RNA Polymerase III Abortive And Retractive Initiation;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Elongation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Polymerase III Transcription Initiation From Type 1 Promoter;RNA Polymerase III Transcription Initiation From Type 1 Promoter;RNA Polymerase III Transcription Initiation From Type 2 Promoter;RNA Polymerase III Transcription Initiation From Type 2 Promoter;RNA Polymerase III Transcription Initiation From Type 3 Promoter;RNA Polymerase III Transcription Initiation From Type 3 Promoter;RNA Pol II CTD phosphorylation and interaction with CE;Signaling by FGFR2 IIIa TM;Estrogen-dependent gene expression 5451 POU2F1 False True Interleukin-4 and Interleukin-13 signaling;RNA polymerase II transcribes snRNA genes;RNA polymerase II transcribes snRNA genes;RNA Polymerase III Abortive And Retractive Initiation;RNA Polymerase III Transcription Initiation From Type 3 Promoter;RNA Polymerase III Transcription Initiation From Type 3 Promoter;Estrogen-dependent gene expression 5464 PPA1 False True Cytosolic tRNA aminoacylation;Pyrophosphate hydrolysis 5465 PPARA False True RORA activates gene expression;BMAL1:CLOCK,NPAS2 activates circadian gene expression;PPARA activates gene expression;PPARA activates gene expression;Transcriptional activation of mitochondrial biogenesis;Activation of gene expression by SREBF (SREBP);Transcriptional regulation of white adipocyte differentiation;Nuclear Receptor transcription pathway;Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha);Circadian Clock;SUMOylation of intracellular receptors 5467 PPARD False True Import of palmitoyl-CoA into the mitochondrial matrix;Regulation of pyruvate dehydrogenase (PDH) complex;Nuclear Receptor transcription pathway;Signaling by Retinoic Acid 5473 PPBP False True Platelet degranulation ;Chemokine receptors bind chemokines;G alpha (i) signalling events;Neutrophil degranulation 5476 CTSA False True Glycosphingolipid metabolism;MHC class II antigen presentation;Sialic acid metabolism;Neutrophil degranulation 5478 PPIA True True Platelet degranulation ;Uncoating of the HIV Virion;Budding and maturation of HIV virion;Integration of provirus;Early Phase of HIV Life Cycle;Minus-strand DNA synthesis;Plus-strand DNA synthesis;Binding and entry of HIV virion;Assembly Of The HIV Virion;APOBEC3G mediated resistance to HIV-1 infection;Calcineurin activates NFAT;Basigin interactions;Neutrophil degranulation;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 5479 PPIB True True Collagen biosynthesis and modifying enzymes 5481 PPID False True ESR-mediated signaling 5494 PPM1A False True Downregulation of SMAD2/3:SMAD4 transcriptional activity;Energy dependent regulation of mTOR by LKB1-AMPK 5495 PPM1B False True ISG15 antiviral mechanism 5496 PPM1G False True NA 5499 PPP1CA False True Triglyceride catabolism;DARPP-32 events;Downregulation of TGF-beta receptor signaling;Circadian Clock 5500 PPP1CB False True Triglyceride catabolism;Downregulation of TGF-beta receptor signaling;Regulation of PLK1 Activity at G2/M Transition;Circadian Clock;RHO GTPases activate PKNs;RHO GTPases activate PKNs;RHO GTPases activate CIT;RHO GTPases Activate ROCKs;RHO GTPases activate PAKs;RHO GTPases activate PAKs 5501 PPP1CC False True Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Triglyceride catabolism;Downregulation of TGF-beta receptor signaling;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;Circadian Clock;RHO GTPases Activate Formins;Mitotic Prometaphase 5504 PPP1R2 False True NA 5509 PPP1R3D False True NA 5511 PPP1R8 False True NA 5515 PPP2CA False True Inhibition of replication initiation of damaged DNA by RB1/E2F1;Spry regulation of FGF signaling;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Integration of energy metabolism;PP2A-mediated dephosphorylation of key metabolic factors;DARPP-32 events;Degradation of beta-catenin by the destruction complex;Beta-catenin phosphorylation cascade;ERK/MAPK targets;ERKs are inactivated;MASTL Facilitates Mitotic Progression;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;Initiation of Nuclear Envelope Reformation;CTLA4 inhibitory signaling;Platelet sensitization by LDL;Disassembly of the destruction complex and recruitment of AXIN to the membrane;Disassembly of the destruction complex and recruitment of AXIN to the membrane;Misspliced GSK3beta mutants stabilize beta-catenin;S33 mutants of beta-catenin aren't phosphorylated;S37 mutants of beta-catenin aren't phosphorylated;S45 mutants of beta-catenin aren't phosphorylated;T41 mutants of beta-catenin aren't phosphorylated;APC truncation mutants have impaired AXIN binding;AXIN missense mutants destabilize the destruction complex;Truncations of AMER1 destabilize the destruction complex;RHO GTPases Activate Formins;RAF activation;Negative regulation of MAPK pathway;Regulation of TP53 Degradation;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Mitotic Prometaphase;Cyclin D associated events in G1;Cyclin A/B1/B2 associated events during G2/M transition;Glycolysis;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 5518 PPP2R1A False True Inhibition of replication initiation of damaged DNA by RB1/E2F1;Spry regulation of FGF signaling;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Integration of energy metabolism;PP2A-mediated dephosphorylation of key metabolic factors;DARPP-32 events;Degradation of beta-catenin by the destruction complex;Beta-catenin phosphorylation cascade;ERK/MAPK targets;ERKs are inactivated;MASTL Facilitates Mitotic Progression;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;Regulation of PLK1 Activity at G2/M Transition;Initiation of Nuclear Envelope Reformation;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;CTLA4 inhibitory signaling;Platelet sensitization by LDL;Disassembly of the destruction complex and recruitment of AXIN to the membrane;Disassembly of the destruction complex and recruitment of AXIN to the membrane;Misspliced GSK3beta mutants stabilize beta-catenin;S33 mutants of beta-catenin aren't phosphorylated;S37 mutants of beta-catenin aren't phosphorylated;S45 mutants of beta-catenin aren't phosphorylated;T41 mutants of beta-catenin aren't phosphorylated;APC truncation mutants have impaired AXIN binding;AXIN missense mutants destabilize the destruction complex;Truncations of AMER1 destabilize the destruction complex;Anchoring of the basal body to the plasma membrane;RHO GTPases Activate Formins;RAF activation;Negative regulation of MAPK pathway;Regulation of TP53 Degradation;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Mitotic Prometaphase;Cyclin D associated events in G1;Cyclin A/B1/B2 associated events during G2/M transition;Glycolysis;AURKA Activation by TPX2;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 5520 PPP2R2A False True Initiation of Nuclear Envelope Reformation;Cyclin D associated events in G1;Cyclin A/B1/B2 associated events during G2/M transition;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 5530 PPP3CA False True DARPP-32 events;Calcineurin activates NFAT;Calcineurin activates NFAT;FCERI mediated Ca+2 mobilization;Ca2+ pathway;CLEC7A (Dectin-1) induces NFAT activation 5534 PPP3R1 False True Activation of BAD and translocation to mitochondria ;DARPP-32 events;Calcineurin activates NFAT;Calcineurin activates NFAT;FCERI mediated Ca+2 mobilization;Ca2+ pathway;CLEC7A (Dectin-1) induces NFAT activation 5536 PPP5C False True Negative regulation of MAPK pathway;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;ESR-mediated signaling 5538 PPT1 False True Fatty acyl-CoA biosynthesis 5546 PRCC False True mRNA Splicing - Major Pathway 5547 PRCP False True Intrinsic Pathway of Fibrin Clot Formation;Neutrophil degranulation 5550 PREP False True NA 5562 PRKAA1 False True Macroautophagy;Energy dependent regulation of mTOR by LKB1-AMPK;TP53 Regulates Metabolic Genes;Regulation of TP53 Activity through Phosphorylation;Activation of AMPK downstream of NMDARs 5563 PRKAA2 False True Translocation of SLC2A4 (GLUT4) to the plasma membrane;Macroautophagy;AMPK inhibits chREBP transcriptional activation activity;AMPK inhibits chREBP transcriptional activation activity;Import of palmitoyl-CoA into the mitochondrial matrix;Activation of PPARGC1A (PGC-1alpha) by phosphorylation;Energy dependent regulation of mTOR by LKB1-AMPK;TP53 Regulates Metabolic Genes;Regulation of TP53 Activity through Phosphorylation;Activation of AMPK downstream of NMDARs 5567 PRKACB False True PKA-mediated phosphorylation of CREB;PKA-mediated phosphorylation of key metabolic factors;Triglyceride catabolism;PKA activation;PKA activation in glucagon signalling;DARPP-32 events;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Rap1 signalling;Regulation of insulin secretion;Vasopressin regulates renal water homeostasis via Aquaporins;VEGFA-VEGFR2 Pathway;CREB1 phosphorylation through the activation of Adenylate Cyclase;CREB1 phosphorylation through the activation of Adenylate Cyclase;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'off' state;CD209 (DC-SIGN) signaling;MAPK6/MAPK4 signaling;Glycolysis;RET signaling;HDL assembly;ROBO receptors bind AKAP5;Factors involved in megakaryocyte development and platelet production 5578 PRKCA False True Calmodulin induced events;Disinhibition of SNARE formation;SHC1 events in ERBB2 signaling;Signaling by SCF-KIT;Regulation of KIT signaling;EGFR Transactivation by Gastrin;Inactivation, recovery and regulation of the phototransduction cascade;Syndecan interactions;Acetylcholine regulates insulin secretion;Ca2+ pathway;Trafficking of GluR2-containing AMPA receptors;G alpha (z) signalling events;Depolymerisation of the Nuclear Lamina;HuR (ELAVL1) binds and stabilizes mRNA;WNT5A-dependent internalization of FZD4;VEGFR2 mediated cell proliferation;RHO GTPases Activate NADPH Oxidases;Response to elevated platelet cytosolic Ca2+;RET signaling;ROBO receptors bind AKAP5;ROBO receptors bind AKAP5 5579 PRKCB False True Disinhibition of SNARE formation;Activation of NF-kappaB in B cells;Trafficking of GluR2-containing AMPA receptors;G alpha (z) signalling events;Depolymerisation of the Nuclear Lamina;WNT5A-dependent internalization of FZD4;VEGFR2 mediated cell proliferation;RHO GTPases Activate NADPH Oxidases;Response to elevated platelet cytosolic Ca2+;RUNX1 regulates transcription of genes involved in differentiation of myeloid cells 5580 PRKCD False True Apoptotic cleavage of cellular proteins;Calmodulin induced events;Effects of PIP2 hydrolysis;SHC1 events in ERBB2 signaling;DAG and IP3 signaling;Role of phospholipids in phagocytosis;G alpha (z) signalling events;HuR (ELAVL1) binds and stabilizes mRNA;VEGFR2 mediated cell proliferation;CLEC7A (Dectin-1) signaling;RHO GTPases Activate NADPH Oxidases;Neutrophil degranulation;Interferon gamma signaling 5581 PRKCE False True Effects of PIP2 hydrolysis;SHC1 events in ERBB2 signaling;DAG and IP3 signaling;Role of phospholipids in phagocytosis;G alpha (z) signalling events 5582 PRKCG False True Calmodulin induced events;Disinhibition of SNARE formation;Trafficking of GluR2-containing AMPA receptors;G alpha (z) signalling events;WNT5A-dependent internalization of FZD4;Response to elevated platelet cytosolic Ca2+ 5583 PRKCH False True Effects of PIP2 hydrolysis;G alpha (z) signalling events 5584 PRKCI False True Pre-NOTCH Transcription and Translation;p75NTR recruits signalling complexes;Tight junction interactions 5585 PKN1 False True RHO GTPases activate PKNs;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 5586 PKN2 False True RHO GTPases activate PKNs 5587 PRKD1 False True Sphingolipid de novo biosynthesis 5588 PRKCQ False True Apoptotic cleavage of cellular proteins;Effects of PIP2 hydrolysis;Downstream TCR signaling;Inactivation, recovery and regulation of the phototransduction cascade;FCERI mediated NF-kB activation;FCERI mediated NF-kB activation;Netrin-1 signaling;G alpha (z) signalling events;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 5589 PRKCSH False True Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);N-glycan trimming in the ER and Calnexin/Calreticulin cycle;Advanced glycosylation endproduct receptor signaling;Post-translational protein phosphorylation;Calnexin/calreticulin cycle 5590 PRKCZ False True GPVI-mediated activation cascade;TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);VEGFR2 mediated cell proliferation;RHO GTPases Activate NADPH Oxidases 5591 PRKDC False True Cytosolic sensors of pathogen-associated DNA ;IRF3-mediated induction of type I IFN;Nonhomologous End-Joining (NHEJ);E3 ubiquitin ligases ubiquitinate target proteins 5593 PRKG2 False True Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation;Ca2+ pathway;cGMP effects;cGMP effects 5594 MAPK1 False True phospho-PLA2 pathway;RAF-independent MAPK1/3 activation;MAPK1 (ERK2) activation;Spry regulation of FGF signaling;Golgi Cisternae Pericentriolar Stack Reorganization;Frs2-mediated activation;ERK/MAPK targets;ERK/MAPK targets;ERKs are inactivated;Regulation of actin dynamics for phagocytic cup formation;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);Oncogene Induced Senescence;Oncogene Induced Senescence;FCERI mediated MAPK activation;Regulation of HSF1-mediated heat shock response;NCAM signaling for neurite out-growth;Recycling pathway of L1;RSK activation;Signal transduction by L1;Activation of the AP-1 family of transcription factors;Thrombin signalling through proteinase activated receptors (PARs);Negative regulation of FGFR1 signaling;Negative regulation of FGFR2 signaling;Negative regulation of FGFR3 signaling;Negative regulation of FGFR4 signaling;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate NADPH Oxidases;RAF/MAP kinase cascade;MAP2K and MAPK activation;Negative feedback regulation of MAPK pathway;Negative regulation of MAPK pathway;Neutrophil degranulation;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Signal attenuation;Advanced glycosylation endproduct receptor signaling;Gastrin-CREB signalling pathway via PKC and MAPK;ESR-mediated signaling;RUNX2 regulates osteoblast differentiation;Regulation of PTEN gene transcription;Regulation of the apoptosome activity;Growth hormone receptor signaling 5596 MAPK4 False True MAPK6/MAPK4 signaling 5598 MAPK7 False True ERK/MAPK targets;ERK/MAPK targets;Signalling to ERK5;Signalling to ERK5;ERKs are inactivated;Senescence-Associated Secretory Phenotype (SASP);Gastrin-CREB signalling pathway via PKC and MAPK;RET signaling 5599 MAPK8 False True Activation of BIM and translocation to mitochondria ;Activation of BMF and translocation to mitochondria;NRAGE signals death through JNK;NRAGE signals death through JNK;NRIF signals cell death from the nucleus;Oxidative Stress Induced Senescence;FCERI mediated MAPK activation;DSCAM interactions;JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1;Activation of the AP-1 family of transcription factors;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Interleukin-38 signaling 5602 MAPK10 False True Oxidative Stress Induced Senescence;FCERI mediated MAPK activation;JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1;Activation of the AP-1 family of transcription factors 5604 MAP2K1 False True MAPK3 (ERK1) activation;Signal transduction by L1;Uptake and function of anthrax toxins;RAF activation;MAP2K and MAPK activation;Negative feedback regulation of MAPK pathway;MAP3K8 (TPL2)-dependent MAPK1/3 activation;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF 5605 MAP2K2 False True MAPK1 (ERK2) activation;Signal transduction by L1;Uptake and function of anthrax toxins;RAF activation;MAP2K and MAPK activation;Negative feedback regulation of MAPK pathway;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF 5606 MAP2K3 False True Oxidative Stress Induced Senescence;activated TAK1 mediates p38 MAPK activation;Uptake and function of anthrax toxins 5607 MAP2K5 False True Signalling to ERK5 5609 MAP2K7 False True Oxidative Stress Induced Senescence;FCERI mediated MAPK activation;JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1;Uptake and function of anthrax toxins 5610 EIF2AK2 False True ISG15 antiviral mechanism;Inhibition of PKR 5613 PRKX False True PKA-mediated phosphorylation of CREB;CREB1 phosphorylation through the activation of Adenylate Cyclase 5616 PRKY False True NA 5621 PRNP False True NCAM1 interactions 5630 PRPH False True NA 5631 PRPS1 False True 5-Phosphoribose 1-diphosphate biosynthesis 5635 PRPSAP1 False True NA 5636 PRPSAP2 False True NA 5641 LGMN False True Trafficking and processing of endosomal TLR;Vitamin D (calciferol) metabolism;MHC class II antigen presentation 5644 PRSS1 False True Activation of Matrix Metalloproteinases;Cobalamin (Cbl, vitamin B12) transport and metabolism 5646 PRSS3 False True Alpha-defensins;Cobalamin (Cbl, vitamin B12) transport and metabolism;Neutrophil degranulation;Antimicrobial peptides 5660 PSAP False True Platelet degranulation ;Glycosphingolipid metabolism;Peptide ligand-binding receptors;G alpha (i) signalling events;Neutrophil degranulation 5663 PSEN1 False True Nuclear signaling by ERBB4;Degradation of the extracellular matrix;Regulated proteolysis of p75NTR;NRIF signals cell death from the nucleus;Activated NOTCH1 Transmits Signal to the Nucleus;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;NOTCH2 Activation and Transmission of Signal to the Nucleus;EPH-ephrin mediated repulsion of cells;Neutrophil degranulation;NOTCH3 Activation and Transmission of Signal to the Nucleus;NOTCH4 Activation and Transmission of Signal to the Nucleus;Noncanonical activation of NOTCH3 5664 PSEN2 False True Nuclear signaling by ERBB4;Regulated proteolysis of p75NTR;NRIF signals cell death from the nucleus;Activated NOTCH1 Transmits Signal to the Nucleus;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;NOTCH2 Activation and Transmission of Signal to the Nucleus;EPH-ephrin mediated repulsion of cells;NOTCH3 Activation and Transmission of Signal to the Nucleus;NOTCH4 Activation and Transmission of Signal to the Nucleus;Noncanonical activation of NOTCH3 5681 PSKH1 False True NA 5682 PSMA1 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation 5683 PSMA2 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation 5684 PSMA3 True True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation 5685 PSMA4 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation 5686 PSMA5 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation 5687 PSMA6 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation 5688 PSMA7 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation 5689 PSMB1 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation 5690 PSMB2 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation 5691 PSMB3 True True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation 5692 PSMB4 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation 5693 PSMB5 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation 5694 PSMB6 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation 5695 PSMB7 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation 5696 PSMB8 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Interferon alpha/beta signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation 5698 PSMB9 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation 5699 PSMB10 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation 5700 PSMC1 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;N-glycan trimming in the ER and Calnexin/Calreticulin cycle;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation 5701 PSMC2 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation 5702 PSMC3 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation 5704 PSMC4 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation 5705 PSMC5 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation 5706 PSMC6 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation 5707 PSMD1 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation 5708 PSMD2 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation 5709 PSMD3 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation 5710 PSMD4 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation 5711 PSMD5 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation 5713 PSMD7 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation 5714 PSMD8 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation 5717 PSMD11 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation 5718 PSMD12 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation 5719 PSMD13 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation 5720 PSME1 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation 5721 PSME2 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation 5725 PTBP1 False True FGFR2 alternative splicing;mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA 5728 PTEN False True Synthesis of PIPs at the plasma membrane;Synthesis of IP3 and IP4 in the cytosol;Negative regulation of the PI3K/AKT network;Downstream TCR signaling;TP53 Regulates Metabolic Genes;PTEN Loss of Function in Cancer;Ub-specific processing proteases;Ovarian tumor domain proteases;Regulation of PTEN mRNA translation;Regulation of PTEN localization;Regulation of PTEN stability and activity;Transcriptional Regulation by MECP2 5730 PTGDS False True Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 5747 PTK2 False True Apoptotic cleavage of cellular proteins;Regulation of actin dynamics for phagocytic cup formation;Integrin alphaIIb beta3 signaling;GRB2:SOS provides linkage to MAPK signaling for Integrins ;p130Cas linkage to MAPK signaling for integrins;NCAM signaling for neurite out-growth;NCAM signaling for neurite out-growth;Signal regulatory protein family interactions;EPHB-mediated forward signaling;EPHB-mediated forward signaling;DCC mediated attractive signaling;DCC mediated attractive signaling;VEGFA-VEGFR2 Pathway;VEGFA-VEGFR2 Pathway;RHO GTPases Activate WASPs and WAVEs;RAF/MAP kinase cascade;MET activates PTK2 signaling 5753 PTK6 False True SCF(Skp2)-mediated degradation of p27/p21;Cyclin D associated events in G1;ERBB2 Activates PTK6 Signaling;PTK6 Regulates Proteins Involved in RNA Processing;PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1;PTK6 Regulates Cell Cycle;PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases;PTK6 Down-Regulation;PTK6 Expression;PTK6 Activates STAT3;PTK6 promotes HIF1A stabilization 5756 TWF1 False True NA 5757 PTMA False True NA 5763 PTMS False True NA 5764 PTN False True NA 5768 QSOX1 False True Platelet degranulation ;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Neutrophil degranulation;Post-translational protein phosphorylation 5770 PTPN1 False True Integrin alphaIIb beta3 signaling;Negative regulation of MET activity;Regulation of IFNG signaling;PTK6 Down-Regulation;MECP2 regulates neuronal receptors and channels;Regulation of IFNA signaling;Growth hormone receptor signaling;Growth hormone receptor signaling 5771 PTPN2 False True Negative regulation of MET activity;Regulation of IFNG signaling;Interleukin-37 signaling 5774 PTPN3 False True EGFR downregulation 5777 PTPN6 False True GPVI-mediated activation cascade;Regulation of KIT signaling;PECAM1 interactions;Costimulation by the CD28 family;PD-1 signaling;Signal regulatory protein family interactions;Platelet sensitization by LDL;Interleukin-3, Interleukin-5 and GM-CSF signaling;CD22 mediated BCR regulation;Neutrophil degranulation;Interferon gamma signaling;Regulation of IFNG signaling;Interleukin-37 signaling;Interferon alpha/beta signaling;Interleukin receptor SHC signaling;Regulation of IFNA signaling;Growth hormone receptor signaling;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 5780 PTPN9 False True Interleukin-37 signaling 5782 PTPN12 False True SHC1 events in ERBB2 signaling;SHC1 events in ERBB2 signaling;EGFR downregulation;Signaling by PDGF;Downregulation of ERBB2 signaling;Interleukin-37 signaling 5784 PTPN14 False True Interleukin-37 signaling 5786 PTPRA False True NCAM signaling for neurite out-growth;NCAM signaling for neurite out-growth;RAF/MAP kinase cascade 5793 PTPRG False True NA 5814 PURB False True NA 5819 PVRL2 False True Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Adherens junctions interactions;Nectin/Necl trans heterodimerization 5824 PEX19 False True ABC transporters in lipid homeostasis 5829 PXN False True GAB1 signalosome;VEGFA-VEGFR2 Pathway;Smooth Muscle Contraction;Localization of the PINCH-ILK-PARVIN complex to focal adhesions;Regulation of cytoskeletal remodeling and cell spreading by IPP complex components;PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 5830 PEX5 False True E3 ubiquitin ligases ubiquitinate target proteins;Peroxisomal protein import;Peroxisomal protein import 5859 QARS False True SeMet incorporation into proteins;Cytosolic tRNA aminoacylation;Mitochondrial tRNA aminoacylation 5860 QDPR False True Phenylalanine and tyrosine catabolism 5861 RAB1A False True Golgi Cisternae Pericentriolar Stack Reorganization;Golgi Cisternae Pericentriolar Stack Reorganization;COPII-mediated vesicle transport;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;RAB geranylgeranylation;RAB GEFs exchange GTP for GDP on RABs 5862 RAB2A False True Golgi Cisternae Pericentriolar Stack Reorganization;RAB geranylgeranylation 5866 RAB3IL1 False True RAB GEFs exchange GTP for GDP on RABs 5867 RAB4A False True Translocation of SLC2A4 (GLUT4) to the plasma membrane;Synthesis of PIPs at the plasma membrane;TBC/RABGAPs;RAB geranylgeranylation;MET receptor recycling 5868 RAB5A False True Synthesis of PIPs at the plasma membrane;TBC/RABGAPs;Clathrin-mediated endocytosis;RAB geranylgeranylation;RAB GEFs exchange GTP for GDP on RABs;Factors involved in megakaryocyte development and platelet production 5869 RAB5B False True Neutrophil degranulation;TBC/RABGAPs;Clathrin-mediated endocytosis;RAB geranylgeranylation;RAB GEFs exchange GTP for GDP on RABs 5871 MAP4K2 False True NA 5879 RAC1 False True GPVI-mediated activation cascade;PIP3 activates AKT signaling;Signaling by SCF-KIT;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Nef and signal transduction;NRAGE signals death through JNK;Rho GTPase cycle;Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;Constitutive Signaling by Aberrant PI3K in Cancer;DAP12 signaling;FCERI mediated MAPK activation;DSCAM interactions;CD28 dependent Vav1 pathway;EPHB-mediated forward signaling;Ephrin signaling;EPH-ephrin mediated repulsion of cells;Sema3A PAK dependent Axon repulsion;SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion;PCP/CE pathway;Sema4D mediated inhibition of cell attachment and migration;DCC mediated attractive signaling;DCC mediated attractive signaling;Activation of RAC1;Inactivation of CDC42 and RAC1;VEGFA-VEGFR2 Pathway;Signal transduction by L1;VEGFR2 mediated vascular permeability;RHO GTPases activate PKNs;RHO GTPases activate CIT;RHO GTPases activate CIT;RHO GTPases activate KTN1;RHO GTPases activate IQGAPs;RHO GTPases activate PAKs;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate Formins;RHO GTPases Activate Formins;RHO GTPases Activate NADPH Oxidases;MAPK6/MAPK4 signaling;Neutrophil degranulation;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases;MET activates RAP1 and RAC1;NTRK2 activates RAC1;Activated NTRK2 signals through CDK5;Activation of RAC1 downstream of NMDARs;Factors involved in megakaryocyte development and platelet production 5885 RAD21 False True Meiotic synapsis;Separation of Sister Chromatids;Establishment of Sister Chromatid Cohesion;Cohesin Loading onto Chromatin;Resolution of Sister Chromatid Cohesion;SUMOylation of DNA damage response and repair proteins;Estrogen-dependent gene expression 5886 RAD23A False True Josephin domain DUBs;DNA Damage Recognition in GG-NER;Formation of Incision Complex in GG-NER 5887 RAD23B False True N-glycan trimming in the ER and Calnexin/Calreticulin cycle;Josephin domain DUBs;DNA Damage Recognition in GG-NER;Formation of Incision Complex in GG-NER 5892 RAD51D False True HDR through Homologous Recombination (HRR);Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA);Resolution of D-loop Structures through Holliday Junction Intermediates;Homologous DNA Pairing and Strand Exchange;Presynaptic phase of homologous DNA pairing and strand exchange;TP53 Regulates Transcription of DNA Repair Genes 5894 RAF1 False True Stimuli-sensing channels;Rap1 signalling;GP1b-IX-V activation signalling;CD209 (DC-SIGN) signaling;RAF activation;MAP2K and MAPK activation;Negative feedback regulation of MAPK pathway;Negative regulation of MAPK pathway;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF 5896 RAG1 False True Interleukin-7 signaling;MAPK6/MAPK4 signaling 5898 RALA False True Translocation of SLC2A4 (GLUT4) to the plasma membrane;Translocation of SLC2A4 (GLUT4) to the plasma membrane;p38MAPK events;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 5901 RAN False True Rev-mediated nuclear export of HIV RNA;Regulation of cholesterol biosynthesis by SREBP (SREBF);NEP/NS2 Interacts with the Cellular Export Machinery;Nuclear import of Rev protein;MicroRNA (miRNA) biogenesis;Transcriptional regulation by small RNAs;tRNA processing in the nucleus 5903 RANBP2 False True ISG15 antiviral mechanism;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Rev-mediated nuclear export of HIV RNA;Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Viral Messenger RNA Synthesis;NEP/NS2 Interacts with the Cellular Export Machinery;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;snRNP Assembly;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;SUMOylation of DNA damage response and repair proteins;SUMOylation of ubiquitinylation proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;SUMOylation of SUMOylation proteins;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins;Transcriptional regulation by small RNAs;RHO GTPases Activate Formins;tRNA processing in the nucleus;Mitotic Prometaphase 5905 RANGAP1 False True Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Rev-mediated nuclear export of HIV RNA;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;SUMOylation of DNA replication proteins;RHO GTPases Activate Formins;Mitotic Prometaphase 5906 RAP1A False True Frs2-mediated activation;ARMS-mediated activation;ARMS-mediated activation;Integrin alphaIIb beta3 signaling;GRB2:SOS provides linkage to MAPK signaling for Integrins ;p130Cas linkage to MAPK signaling for integrins;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Rap1 signalling;MAP2K and MAPK activation;Neutrophil degranulation;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF;MET activates RAP1 and RAC1 5910 RAP1GDS1 False True NA 5913 RAPSN False True NA 5914 RARA False True Nuclear Receptor transcription pathway;SUMOylation of intracellular receptors;Signaling by Retinoic Acid;Activation of anterior HOX genes in hindbrain development during early embryogenesis 5917 RARS False True SeMet incorporation into proteins;Cytosolic tRNA aminoacylation 5920 RARRES3 False True Acyl chain remodelling of PE 5925 RB1 False True Inhibition of replication initiation of damaged DNA by RB1/E2F1;Inhibition of replication initiation of damaged DNA by RB1/E2F1;Condensation of Prophase Chromosomes;Formation of Senescence-Associated Heterochromatin Foci (SAHF);Oncogene Induced Senescence;Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes;Cyclin E associated events during G1/S transition ;Cyclin D associated events in G1;Cyclin A:Cdk2-associated events at S phase entry;RUNX2 regulates osteoblast differentiation 5928 RBBP4 False True Transcription of E2F targets under negative control by DREAM complex;Transcription of E2F targets under negative control by DREAM complex;Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1;G0 and Early G1;Polo-like kinase mediated events;PRC2 methylates histones and DNA;Oxidative Stress Induced Senescence;HDACs deacetylate histones;PKMTs methylate histone lysines;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;Activation of E2F1 target genes at G1/S;Activation of anterior HOX genes in hindbrain development during early embryogenesis;Deposition of new CENPA-containing nucleosomes at the centromere;Regulation of TP53 Activity through Acetylation;Cyclin E associated events during G1/S transition ;Cyclin A:Cdk2-associated events at S phase entry;RNA Polymerase I Transcription Initiation;Regulation of PTEN gene transcription;Regulation of PTEN gene transcription;Transcriptional Regulation by E2F6 5929 RBBP5 False True Formation of the beta-catenin:TCF transactivating complex;PKMTs methylate histone lysines;Deactivation of the beta-catenin transactivating complex;Activation of anterior HOX genes in hindbrain development during early embryogenesis;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Neddylation 5936 RBM4 False True Circadian Clock 5937 RBMS1 False True NA 5939 RBMS2 False True NA 5940 RBMY1A1 False True NA 5954 RCN1 False True Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation 5955 RCN2 False True NA 5962 RDX False True Recycling pathway of L1;Recycling pathway of L1 5970 RELA False True Activation of NF-kappaB in B cells;RIP-mediated NFkB activation via ZBP1;Regulated proteolysis of p75NTR;Downstream TCR signaling;NF-kB is activated and signals survival;Senescence-Associated Secretory Phenotype (SASP);FCERI mediated NF-kB activation;DEx/H-box helicases activate type I IFN and inflammatory cytokines production ;PKMTs methylate histone lysines;Transcriptional regulation of white adipocyte differentiation;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;Interleukin-1 processing;SUMOylation of immune response proteins;IkBA variant leads to EDA-ID;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;CD209 (DC-SIGN) signaling;CLEC7A/inflammasome pathway;The NLRP3 inflammasome;Interleukin-1 signaling;TRAF6 mediated NF-kB activation 5976 UPF1 False True Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 5979 RET False True RAF/MAP kinase cascade;RET signaling 5981 RFC1 False True Translesion synthesis by REV1;Recognition of DNA damage by PCNA-containing replication complex;Translesion Synthesis by POLH;Polymerase switching on the C-strand of the telomere;PCNA-Dependent Long Patch Base Excision Repair;Translesion synthesis by POLK;Translesion synthesis by POLI;Termination of translesion DNA synthesis;HDR through Homologous Recombination (HRR);Gap-filling DNA repair synthesis and ligation in GG-NER;Dual Incision in GG-NER;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Polymerase switching 5987 TRIM27 False True SUMOylation of ubiquitinylation proteins;Regulation of PTEN stability and activity 5998 RGS3 False True G alpha (q) signalling events;G alpha (i) signalling events 6000 RGS7 False True G alpha (i) signalling events;G alpha (i) signalling events;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 6005 RHAG False True Erythrocytes take up carbon dioxide and release oxygen;Erythrocytes take up oxygen and release carbon dioxide;Rhesus glycoproteins mediate ammonium transport.;Defective RHAG causes regulator type Rh-null hemolytic anemia (RHN) 6009 RHEB False True Macroautophagy;mTOR signalling;mTORC1-mediated signalling;Energy dependent regulation of mTOR by LKB1-AMPK;TP53 Regulates Metabolic Genes;Regulation of PTEN gene transcription 6018 NA False True NA 6050 RNH1 False True NA 6059 ABCE1 False True OAS antiviral response;Interferon alpha/beta signaling 6100 RP9 False True NA 6117 RPA1 False True Translesion synthesis by REV1;Recognition of DNA damage by PCNA-containing replication complex;Translesion Synthesis by POLH;Removal of the Flap Intermediate from the C-strand;Activation of ATR in response to replication stress;SUMOylation of DNA damage response and repair proteins;Regulation of HSF1-mediated heat shock response;HSF1 activation;Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha);Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta);Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta);PCNA-Dependent Long Patch Base Excision Repair;Translesion synthesis by POLK;Translesion synthesis by POLI;Termination of translesion DNA synthesis;HDR through Single Strand Annealing (SSA);HDR through Homologous Recombination (HRR);Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;Formation of Incision Complex in GG-NER;Gap-filling DNA repair synthesis and ligation in GG-NER;Dual Incision in GG-NER;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Fanconi Anemia Pathway;Regulation of TP53 Activity through Phosphorylation;Activation of the pre-replicative complex;Removal of the Flap Intermediate;G2/M DNA damage checkpoint;Meiotic recombination 6118 RPA2 False True Translesion synthesis by REV1;Recognition of DNA damage by PCNA-containing replication complex;Translesion Synthesis by POLH;Removal of the Flap Intermediate from the C-strand;Activation of ATR in response to replication stress;Regulation of HSF1-mediated heat shock response;HSF1 activation;Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha);Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta);Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta);PCNA-Dependent Long Patch Base Excision Repair;Translesion synthesis by POLK;Translesion synthesis by POLI;Termination of translesion DNA synthesis;HDR through Single Strand Annealing (SSA);HDR through Homologous Recombination (HRR);Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;Formation of Incision Complex in GG-NER;Gap-filling DNA repair synthesis and ligation in GG-NER;Dual Incision in GG-NER;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Fanconi Anemia Pathway;Regulation of TP53 Activity through Phosphorylation;Activation of the pre-replicative complex;Removal of the Flap Intermediate;G2/M DNA damage checkpoint;Meiotic recombination 6119 RPA3 False True Translesion synthesis by REV1;Recognition of DNA damage by PCNA-containing replication complex;Translesion Synthesis by POLH;Removal of the Flap Intermediate from the C-strand;Activation of ATR in response to replication stress;Regulation of HSF1-mediated heat shock response;HSF1 activation;Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha);Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta);Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta);PCNA-Dependent Long Patch Base Excision Repair;Translesion synthesis by POLK;Translesion synthesis by POLI;Termination of translesion DNA synthesis;HDR through Single Strand Annealing (SSA);HDR through Homologous Recombination (HRR);Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;Formation of Incision Complex in GG-NER;Gap-filling DNA repair synthesis and ligation in GG-NER;Dual Incision in GG-NER;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Fanconi Anemia Pathway;Regulation of TP53 Activity through Phosphorylation;Activation of the pre-replicative complex;Removal of the Flap Intermediate;G2/M DNA damage checkpoint;Meiotic recombination 6120 RPE False True Pentose phosphate pathway 6122 RPL3 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6124 RPL4 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6125 RPL5 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6128 RPL6 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6129 RPL7 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6130 RPL7A False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6132 RPL8 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6133 RPL9 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6134 RPL10 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6135 RPL11 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6136 RPL12 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6137 RPL13 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6138 RPL15 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6139 RPL17 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6141 RPL18 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6142 RPL18A False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6143 RPL19 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6144 RPL21 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6146 RPL22 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6147 RPL23A False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6152 RPL24 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6154 RPL26 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6155 RPL27 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6156 RPL30 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6157 RPL27A False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6158 RPL28 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6159 RPL29 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6160 RPL31 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6161 RPL32 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6164 RPL34 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6165 RPL35A False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6167 RPL37 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6168 RPL37A False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6169 RPL38 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6173 RPL36A False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6175 RPLP0 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6176 RPLP1 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6181 RPLP2 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6182 MRPL12 False True Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation elongation;Mitochondrial translation termination 6183 MRPS12 False True Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation elongation;Mitochondrial translation termination 6184 RPN1 False True SRP-dependent cotranslational protein targeting to membrane;Asparagine N-linked glycosylation 6185 RPN2 False True SRP-dependent cotranslational protein targeting to membrane;Asparagine N-linked glycosylation 6187 RPS2 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;RMTs methylate histone arginines;rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Protein methylation;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6188 RPS3 True True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6189 RPS3A False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6191 RPS4X False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6193 RPS5 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6194 RPS6 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;mTORC1-mediated signalling;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6195 RPS6KA1 False True ERK/MAPK targets;CREB phosphorylation;Senescence-Associated Secretory Phenotype (SASP);Senescence-Associated Secretory Phenotype (SASP);Recycling pathway of L1;CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling;RSK activation;RSK activation;Gastrin-CREB signalling pathway via PKC and MAPK 6196 RPS6KA2 False True ERK/MAPK targets;CREB phosphorylation;Senescence-Associated Secretory Phenotype (SASP);Senescence-Associated Secretory Phenotype (SASP);Recycling pathway of L1;CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling;RSK activation;RSK activation;Gastrin-CREB signalling pathway via PKC and MAPK 6197 RPS6KA3 False True ERK/MAPK targets;CREB phosphorylation;Senescence-Associated Secretory Phenotype (SASP);Senescence-Associated Secretory Phenotype (SASP);Recycling pathway of L1;CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling;RSK activation;RSK activation;Gastrin-CREB signalling pathway via PKC and MAPK 6198 RPS6KB1 False True mTORC1-mediated signalling 6199 RPS6KB2 False True AKT phosphorylates targets in the nucleus;Constitutive Signaling by AKT1 E17K in Cancer 6201 RPS7 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6202 RPS8 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6203 RPS9 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6204 RPS10 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6205 RPS11 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6206 RPS12 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6207 RPS13 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6208 RPS14 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6209 RPS15 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6210 RPS15A False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6217 RPS16 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6218 RPS17 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6222 RPS18 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6223 RPS19 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6224 RPS20 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6227 RPS21 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6228 RPS23 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6229 RPS24 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6230 RPS25 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6231 RPS26 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6232 RPS27 False True Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Major pathway of rRNA processing in the nucleolus and cytosol;Mitotic Prometaphase;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6233 RPS27A False True Translesion synthesis by REV1;Recognition of DNA damage by PCNA-containing replication complex;Translesion Synthesis by POLH;Activation of NF-kappaB in B cells;ISG15 antiviral mechanism;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants;ER-Phagosome pathway;Downregulation of ERBB4 signaling;Spry regulation of FGF signaling;Downregulation of ERBB2:ERBB3 signaling;L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;Budding and maturation of HIV virion;NOD1/2 Signaling Pathway;TICAM1, RIP1-mediated IKK complex recruitment ;DDX58/IFIH1-mediated induction of interferon-alpha/beta;APC/C:Cdc20 mediated degradation of Cyclin B;Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Membrane binding and targetting of GAG proteins;Assembly Of The HIV Virion;APC-Cdc20 mediated degradation of Nek2A;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;EGFR downregulation;SCF(Skp2)-mediated degradation of p27/p21;Viral mRNA Translation;Degradation of beta-catenin by the destruction complex;TCF dependent signaling in response to WNT;Downstream TCR signaling;NRIF signals cell death from the nucleus;p75NTR recruits signalling complexes;NF-kB is activated and signals survival;Regulation of activated PAK-2p34 by proteasome mediated degradation;NOTCH1 Intracellular Domain Regulates Transcription;Activated NOTCH1 Transmits Signal to the Nucleus;Activated NOTCH1 Transmits Signal to the Nucleus;Downregulation of TGF-beta receptor signaling;Downregulation of TGF-beta receptor signaling;TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);Downregulation of SMAD2/3:SMAD4 transcriptional activity;Downregulation of SMAD2/3:SMAD4 transcriptional activity;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;Selenocysteine synthesis;Separation of Sister Chromatids;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);Oncogene Induced Senescence;Regulation of PLK1 Activity at G2/M Transition;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Stimuli-sensing channels;Constitutive Signaling by NOTCH1 HD Domain Mutants;FCERI mediated NF-kB activation;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;NOTCH2 Activation and Transmission of Signal to the Nucleus;Regulation of innate immune responses to cytosolic DNA;Glycogen synthesis;Autodegradation of the E3 ubiquitin ligase COP1;Deactivation of the beta-catenin transactivating complex;Myoclonic epilepsy of Lafora;ABC-family proteins mediated transport;Circadian Clock;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;activated TAK1 mediates p38 MAPK activation;JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Regulation of FZD by ubiquitination;Pink/Parkin Mediated Mitophagy;N-glycan trimming in the ER and Calnexin/Calreticulin cycle;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Hedgehog 'on' state;Negative regulation of FGFR1 signaling;Negative regulation of FGFR2 signaling;Negative regulation of FGFR3 signaling;Negative regulation of FGFR4 signaling;Translesion synthesis by POLK;Translesion synthesis by POLI;Termination of translesion DNA synthesis;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;Negative regulation of MAPK pathway;Regulation of necroptotic cell death;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAP3K8 (TPL2)-dependent MAPK1/3 activation;HDR through Homologous Recombination (HRR);MAPK6/MAPK4 signaling;UCH proteinases;UCH proteinases;Josephin domain DUBs;Ub-specific processing proteases;Ovarian tumor domain proteases;Metalloprotease DUBs;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Processing of DNA double-strand break ends;DNA Damage Recognition in GG-NER;Formation of Incision Complex in GG-NER;Gap-filling DNA repair synthesis and ligation in GG-NER;Dual Incision in GG-NER;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Fanconi Anemia Pathway;Major pathway of rRNA processing in the nucleolus and cytosol;Regulation of TP53 Activity through Phosphorylation;Regulation of TP53 Degradation;Regulation of TP53 Activity through Methylation;Negative regulation of MET activity;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;Cyclin D associated events in G1;G2/M Checkpoints;Stabilization of p53;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Downregulation of ERBB2 signaling;Synthesis of active ubiquitin: roles of E1 and E2 enzymes;Synthesis of active ubiquitin: roles of E1 and E2 enzymes;E3 ubiquitin ligases ubiquitinate target proteins;InlB-mediated entry of Listeria monocytogenes into host cell;InlA-mediated entry of Listeria monocytogenes into host cells;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN localization;Regulation of PTEN stability and activity;Neddylation;ER Quality Control Compartment (ERQC);Regulation of expression of SLITs and ROBOs;Regulation of expression of SLITs and ROBOs;NOTCH3 Activation and Transmission of Signal to the Nucleus;NOTCH3 Activation and Transmission of Signal to the Nucleus;TICAM1-dependent activation of IRF3/IRF7;TICAM1,TRAF6-dependent induction of TAK1 complex;Interleukin-1 signaling;Peroxisomal protein import;Peroxisomal protein import;Regulation of signaling by CBL;Endosomal Sorting Complex Required For Transport (ESCRT);Iron uptake and transport;Negative regulators of DDX58/IFIH1 signaling;Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon;IRAK1 recruits IKK complex;IKK complex recruitment mediated by RIP1;IRAK2 mediated activation of TAK1 complex;TRAF6-mediated induction of TAK1 complex within TLR4 complex;Negative regulation of NOTCH4 signaling;TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling;IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation;IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);Amyloid fiber formation;Antigen processing: Ubiquitination & Proteasome degradation 6235 RPS29 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6236 RRAD False True NA 6240 RRM1 False True Interconversion of nucleotide di- and triphosphates 6241 RRM2 False True Interconversion of nucleotide di- and triphosphates;Activation of E2F1 target genes at G1/S;Transcriptional Regulation by E2F6 6248 RSC1A1 False True Organic cation transport;Intestinal hexose absorption 6251 RSU1 False True Regulation of cytoskeletal remodeling and cell spreading by IPP complex components 6252 RTN1 False True NA 6262 RYR2 False True Stimuli-sensing channels;Ion homeostasis 6275 S100A4 False True NA 6278 S100A7 True True Neutrophil degranulation;Metal sequestration by antimicrobial proteins 6281 S100A10 False True Dissolution of Fibrin Clot 6282 S100A11 True True Neutrophil degranulation 6294 SAFB False True SUMOylation of transcription cofactors 6301 SARS False True Selenocysteine synthesis;Cytosolic tRNA aminoacylation 6303 SAT1 False True Interconversion of polyamines 6305 SBF1 False True Synthesis of PIPs at the ER membrane;RAB GEFs exchange GTP for GDP on RABs 6310 ATXN1 False True NA 6317 SERPINB3 True True Neutrophil degranulation 6318 SERPINB4 True True NA 6319 SCD False True Activation of gene expression by SREBF (SREBP);Fatty acyl-CoA biosynthesis 6331 SCN5A False True Interaction between L1 and Ankyrins;Phase 0 - rapid depolarisation 6340 SCNN1G False True Stimuli-sensing channels 6386 SDCBP False True Ephrin signaling;Neurofascin interactions;Neutrophil degranulation 6390 SDHB False True Respiratory electron transport;Citric acid cycle (TCA cycle) 6396 SEC13 False True ISG15 antiviral mechanism;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Rev-mediated nuclear export of HIV RNA;Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Viral Messenger RNA Synthesis;NEP/NS2 Interacts with the Cellular Export Machinery;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;snRNP Assembly;COPII-mediated vesicle transport;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;SUMOylation of DNA damage response and repair proteins;SUMOylation of ubiquitinylation proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;SUMOylation of SUMOylation proteins;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;Transcriptional regulation by small RNAs;RHO GTPases Activate Formins;tRNA processing in the nucleus;Mitotic Prometaphase;Antigen Presentation: Folding, assembly and peptide loading of class I MHC 6399 TRAPPC2 False True COPII-mediated vesicle transport;RAB GEFs exchange GTP for GDP on RABs 6400 SEL1L False True Pre-NOTCH Processing in Golgi;ABC-family proteins mediated transport;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Defective CFTR causes cystic fibrosis;ER Quality Control Compartment (ERQC) 6418 SET False True Condensation of Prophase Chromosomes;HuR (ELAVL1) binds and stabilizes mRNA 6421 SFPQ False True PTK6 Regulates Proteins Involved in RNA Processing 6426 SRSF1 False True Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;mRNA 3'-end processing 6427 SRSF2 False True Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;mRNA 3'-end processing 6428 SRSF3 False True Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing 6429 SRSF4 False True Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing 6430 SRSF5 False True Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing 6431 SRSF6 False True Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;mRNA 3'-end processing 6432 SRSF7 False True Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;mRNA 3'-end processing 6434 TRA2B False True mRNA Splicing - Major Pathway 6440 SFTPC False True Surfactant metabolism;Defective pro-SFTPC causes pulmonary surfactant metabolism dysfunction 2 (SMDP2) and respiratory distress syndrome (RDS);Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5);Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4) 6441 SFTPD False True Toll Like Receptor 4 (TLR4) Cascade;Toll Like Receptor TLR1:TLR2 Cascade;Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;Signal regulatory protein family interactions;Surfactant metabolism;Regulation of TLR by endogenous ligand;Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5);Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4) 6446 SGK1 False True Stimuli-sensing channels;Regulation of TP53 Degradation;Transcriptional Regulation by MECP2 6449 SGTA False True NA 6450 SH3BGR False True NA 6455 SH3GL1 False True EGFR downregulation;Negative regulation of MET activity;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;InlB-mediated entry of Listeria monocytogenes into host cell 6456 SH3GL2 False True Retrograde neurotrophin signalling;Retrograde neurotrophin signalling;EGFR downregulation;MHC class II antigen presentation;Lysosome Vesicle Biogenesis;Golgi Associated Vesicle Biogenesis;Recycling pathway of L1;Recycling pathway of L1;Negative regulation of MET activity;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;InlB-mediated entry of Listeria monocytogenes into host cell 6472 SHMT2 False True Metabolism of folate and pterines 6477 SIAH1 False True Netrin-1 signaling;Amyloid fiber formation;Antigen processing: Ubiquitination & Proteasome degradation 6493 SIM2 False True NA 6494 SIPA1 False True Rap1 signalling 6500 SKP1 False True Activation of NF-kappaB in B cells;Prolactin receptor signaling;SCF-beta-TrCP mediated degradation of Emi1;Vpu mediated degradation of CD4;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;NOTCH1 Intracellular Domain Regulates Transcription;Regulation of PLK1 Activity at G2/M Transition;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling;FCERI mediated NF-kB activation;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Circadian Clock;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;NIK-->noncanonical NF-kB signaling;MAP3K8 (TPL2)-dependent MAPK1/3 activation;Orc1 removal from chromatin;Cyclin D associated events in G1;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Neddylation;Interleukin-1 signaling;Iron uptake and transport;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation 6502 SKP2 False True APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;SCF(Skp2)-mediated degradation of p27/p21;Ub-specific processing proteases;Orc1 removal from chromatin;Cyclin D associated events in G1;Regulation of RUNX2 expression and activity;Neddylation;Antigen processing: Ubiquitination & Proteasome degradation 6505 SLC1A1 False True Glutamate Neurotransmitter Release Cycle;Transport of inorganic cations/anions and amino acids/oligopeptides;Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA) 6510 SLC1A5 False True Amino acid transport across the plasma membrane 6518 SLC2A5 False True Neutrophil degranulation;Intestinal hexose absorption 6520 SLC3A2 False True Basigin interactions;Amino acid transport across the plasma membrane;Tryptophan catabolism 6531 SLC6A3 False True Dopamine clearance from the synaptic cleft;Na+/Cl- dependent neurotransmitter transporters;Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS);Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) 6541 SLC7A1 False True Amino acid transport across the plasma membrane 6548 SLC9A1 False True Hyaluronan uptake and degradation;Sodium/Proton exchangers 6586 NA False True Netrin-1 signaling;Signaling by ROBO receptors;Signaling by ROBO receptors;Regulation of commissural axon pathfinding by SLIT and ROBO 6588 SLN False True Ion homeostasis;Ion transport by P-type ATPases 6595 SMARCA2 False True RMTs methylate histone arginines;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 6597 SMARCA4 False True Interleukin-7 signaling;Formation of the beta-catenin:TCF transactivating complex;RMTs methylate histone arginines;Chromatin modifying enzymes;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 6602 SMARCD1 False True RMTs methylate histone arginines;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 6605 SMARCE1 False True RMTs methylate histone arginines;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 6606 SMN1 False True snRNP Assembly 6612 SUMO3 False True SUMO is conjugated to E1 (UBA2:SAE1);SUMO is transferred from E1 to E2 (UBE2I, UBC9);SUMO is proteolytically processed;SUMOylation of DNA damage response and repair proteins;SUMOylation of transcription factors;SUMOylation of transcription cofactors;SUMOylation of intracellular receptors;SUMOylation of intracellular receptors;SUMOylation of chromatin organization proteins;SUMOylation of DNA replication proteins;SUMOylation of immune response proteins;Formation of Incision Complex in GG-NER 6613 SUMO2 False True Vitamin D (calciferol) metabolism;SUMO is conjugated to E1 (UBA2:SAE1);SUMO is transferred from E1 to E2 (UBE2I, UBC9);SUMO is proteolytically processed;SUMOylation of DNA damage response and repair proteins;SUMOylation of transcription factors;SUMOylation of transcription cofactors;SUMOylation of SUMOylation proteins;SUMOylation of intracellular receptors;SUMOylation of intracellular receptors;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;Processing of DNA double-strand break ends;Formation of Incision Complex in GG-NER 6617 SNAPC1 False True RNA polymerase II transcribes snRNA genes;RNA polymerase II transcribes snRNA genes;RNA Polymerase III Abortive And Retractive Initiation;RNA Polymerase III Transcription Initiation From Type 3 Promoter;RNA Polymerase III Transcription Initiation From Type 3 Promoter 6620 SNCB False True MTF1 activates gene expression 6622 SNCA False True Amyloid fiber formation 6625 SNRNP70 False True mRNA Splicing - Major Pathway 6626 SNRPA False True mRNA Splicing - Major Pathway 6627 SNRPA1 False True mRNA Splicing - Major Pathway;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 6628 SNRPB False True Cleavage of Growing Transcript in the Termination Region ;SLBP independent Processing of Histone Pre-mRNAs;snRNP Assembly;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 6631 SNRPC False True mRNA Splicing - Major Pathway 6632 SNRPD1 False True snRNP Assembly;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway 6633 SNRPD2 False True snRNP Assembly;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway 6634 SNRPD3 False True Cleavage of Growing Transcript in the Termination Region ;SLBP independent Processing of Histone Pre-mRNAs;snRNP Assembly;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 6636 SNRPF False True Cleavage of Growing Transcript in the Termination Region ;SLBP independent Processing of Histone Pre-mRNAs;snRNP Assembly;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway;SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 6638 SNRPN False True mRNA Splicing - Major Pathway 6647 SOD1 True True Platelet degranulation ;Detoxification of Reactive Oxygen Species;Detoxification of Reactive Oxygen Species;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 6648 SOD2 False True Transcriptional activation of mitochondrial biogenesis;Detoxification of Reactive Oxygen Species;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 6651 SON False True NA 6652 SORD False True Fructose biosynthesis;Formation of xylulose-5-phosphate 6667 SP1 False True PPARA activates gene expression;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;Activation of gene expression by SREBF (SREBP);Oncogene Induced Senescence;RNA polymerase II transcribes snRNA genes;RNA polymerase II transcribes snRNA genes;Estrogen-dependent gene expression 6675 UAP1 False True Synthesis of UDP-N-acetyl-glucosamine 6683 SPAST False True NA 6693 SPN False True Cell surface interactions at the vascular wall;Basigin interactions 6697 SPR False True Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation;eNOS activation 6699 NA True False Formation of the cornified envelope 6704 NA True False Formation of the cornified envelope 6708 SPTA1 False True NCAM signaling for neurite out-growth;NCAM signaling for neurite out-growth;Interaction between L1 and Ankyrins;Interaction between L1 and Ankyrins;RAF/MAP kinase cascade;COPI-mediated anterograde transport 6709 SPTAN1 False True Caspase-mediated cleavage of cytoskeletal proteins;Nephrin family interactions;NCAM signaling for neurite out-growth;NCAM signaling for neurite out-growth;Interaction between L1 and Ankyrins;Interaction between L1 and Ankyrins;RAF/MAP kinase cascade;Neutrophil degranulation;COPI-mediated anterograde transport 6711 SPTBN1 False True Nephrin family interactions;NCAM signaling for neurite out-growth;NCAM signaling for neurite out-growth;Interaction between L1 and Ankyrins;Interaction between L1 and Ankyrins;RAF/MAP kinase cascade;COPI-mediated anterograde transport 6712 SPTBN2 False True MHC class II antigen presentation;NCAM signaling for neurite out-growth;NCAM signaling for neurite out-growth;Interaction between L1 and Ankyrins;Interaction between L1 and Ankyrins;RAF/MAP kinase cascade;COPI-mediated anterograde transport 6713 SQLE False True Cholesterol biosynthesis;Activation of gene expression by SREBF (SREBP) 6714 SRC False True Signaling by ERBB2;Nuclear signaling by ERBB4;PIP3 activates AKT signaling;Spry regulation of FGF signaling;Signaling by SCF-KIT;Signaling by SCF-KIT;Regulation of KIT signaling;p38MAPK events;Signaling by EGFR;GAB1 signalosome;Downstream signal transduction;c-src mediated regulation of Cx43 function and closure of gap junctions;FCGR activation;PECAM1 interactions;Constitutive Signaling by Aberrant PI3K in Cancer;EPH-Ephrin signaling;Integrin alphaIIb beta3 signaling;GRB2:SOS provides linkage to MAPK signaling for Integrins ;p130Cas linkage to MAPK signaling for integrins;NCAM signaling for neurite out-growth;CD28 co-stimulation;CTLA4 inhibitory signaling;Signal regulatory protein family interactions;EPHB-mediated forward signaling;EPHB-mediated forward signaling;EPHA-mediated growth cone collapse;EPHA-mediated growth cone collapse;Ephrin signaling;Ephrin signaling;EPH-ephrin mediated repulsion of cells;G alpha (s) signalling events;ADP signalling through P2Y purinoceptor 1;G alpha (i) signalling events;DCC mediated attractive signaling;DCC mediated attractive signaling;Netrin mediated repulsion signals;Regulation of commissural axon pathfinding by SLIT and ROBO;GP1b-IX-V activation signalling;Recycling pathway of L1;VEGFA-VEGFR2 Pathway;VEGFA-VEGFR2 Pathway;Thrombin signalling through proteinase activated receptors (PARs);VEGFR2 mediated cell proliferation;CLEC7A (Dectin-1) signaling;RHO GTPases Activate Formins;RAF activation;MAP2K and MAPK activation;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;Cyclin D associated events in G1;RET signaling;MET activates PTK2 signaling;InlA-mediated entry of Listeria monocytogenes into host cells;Regulation of RUNX1 Expression and Activity;Receptor Mediated Mitophagy;RUNX2 regulates osteoblast differentiation;Regulation of RUNX3 expression and activity;Activated NTRK2 signals through FYN;Activated NTRK3 signals through PI3K;Activated NTRK3 signals through PI3K;Long-term potentiation 6717 SRI False True Stimuli-sensing channels;Reduction of cytosolic Ca++ levels;Sodium/Calcium exchangers;Ion homeostasis;Ion transport by P-type ATPases 6720 SREBF1 False True RORA activates gene expression;Regulation of cholesterol biosynthesis by SREBP (SREBF);Regulation of cholesterol biosynthesis by SREBP (SREBF);PPARA activates gene expression;Activation of gene expression by SREBF (SREBP);Activation of gene expression by SREBF (SREBP);Transcriptional regulation of white adipocyte differentiation;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 6726 SRP9 False True SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane 6727 SRP14 False True SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Neutrophil degranulation 6728 SRP19 False True SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane 6729 SRP54 False True SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane 6731 SRP72 False True SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane 6732 SRPK1 False True NA 6737 TRIM21 False True STING mediated induction of host immune responses;Regulation of innate immune responses to cytosolic DNA;Interferon gamma signaling;Antigen processing: Ubiquitination & Proteasome degradation 6741 SSB False True RNA Polymerase III Transcription Termination;RNA Polymerase III Abortive And Retractive Initiation 6742 SSBP1 False True Transcriptional activation of mitochondrial biogenesis 6744 SSFA2 False True NA 6747 SSR3 False True SRP-dependent cotranslational protein targeting to membrane 6748 SSR4 False True SRP-dependent cotranslational protein targeting to membrane 6749 SSRP1 False True Formation of RNA Pol II elongation complex ;Formation of HIV elongation complex in the absence of HIV Tat;Formation of HIV-1 elongation complex containing HIV-1 Tat;Pausing and recovery of Tat-mediated HIV elongation;Tat-mediated HIV elongation arrest and recovery;Tat-mediated elongation of the HIV-1 transcript;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;RNA Polymerase II Pre-transcription Events;TP53 Regulates Transcription of DNA Repair Genes;Regulation of TP53 Activity through Phosphorylation;RNA Polymerase II Transcription Elongation 6764 ST5 False True RAB GEFs exchange GTP for GDP on RABs 6767 ST13 False True Regulation of HSF1-mediated heat shock response 6769 STAC False True NA 6772 STAT1 False True Interleukin-6 signaling;ISG15 antiviral mechanism;Signaling by SCF-KIT;Signaling by cytosolic FGFR1 fusion mutants;Downstream signal transduction;Interleukin-4 and Interleukin-13 signaling;Interferon gamma signaling;Regulation of IFNG signaling;Interleukin-20 family signaling;Regulation of RUNX2 expression and activity;Interleukin-35 Signalling;Interleukin-9 signaling;NOTCH3 Intracellular Domain Regulates Transcription;NOTCH3 Intracellular Domain Regulates Transcription;Interleukin-27 signaling;Interleukin-21 signaling;Interferon alpha/beta signaling;Regulation of IFNA signaling;Growth hormone receptor signaling 6773 STAT2 False True Interleukin-20 family signaling;Interferon alpha/beta signaling;Regulation of IFNA signaling;Regulation of IFNA signaling 6774 STAT3 False True Interleukin-6 signaling;BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members;Interleukin-7 signaling;Interleukin-7 signaling;Signaling by SCF-KIT;Signaling by cytosolic FGFR1 fusion mutants;Downstream signal transduction;Signalling to STAT3;Senescence-Associated Secretory Phenotype (SASP);Signaling by Leptin;POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation;Association of TriC/CCT with target proteins during biosynthesis;Transcriptional regulation of pluripotent stem cells;Interleukin-10 signaling;Interleukin-4 and Interleukin-13 signaling;PTK6 Activates STAT3;PTK6 Activates STAT3;Interleukin-20 family signaling;MET activates STAT3;MET activates STAT3;Interleukin-15 signaling;Interleukin-35 Signalling;Interleukin-9 signaling;Interleukin-37 signaling;Interleukin-23 signaling;Interleukin-23 signaling;Interleukin-27 signaling;Interleukin-21 signaling;Growth hormone receptor signaling 6778 STAT6 False True Downstream signal transduction;STAT6-mediated induction of chemokines;Interleukin-4 and Interleukin-13 signaling 6779 NA False True NA 6780 STAU1 False True NA 6785 ELOVL4 False True Synthesis of very long-chain fatty acyl-CoAs 6786 STIM1 False True Elevation of cytosolic Ca2+ levels;Ion homeostasis;Ion homeostasis;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 6793 STK10 False True Neutrophil degranulation 6794 STK11 False True AMPK inhibits chREBP transcriptional activation activity;Energy dependent regulation of mTOR by LKB1-AMPK;Regulation of TP53 Activity through Phosphorylation;FOXO-mediated transcription of cell death genes 6795 AURKC False True NA 6801 STRN False True NA 6809 STX3 False True Other interleukin signaling 6810 STX4 False True Disinhibition of SNARE formation;ER-Phagosome pathway;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Clathrin derived vesicle budding;Other interleukin signaling 6811 STX5 False True COPII-mediated vesicle transport;Cargo concentration in the ER;COPI-mediated anterograde transport;Intra-Golgi traffic 6812 STXBP1 False True Serotonin Neurotransmitter Release Cycle;Norepinephrine Neurotransmitter Release Cycle;Glutamate Neurotransmitter Release Cycle;Dopamine Neurotransmitter Release Cycle;Acetylcholine Neurotransmitter Release Cycle;Regulation of insulin secretion;Neurexins and neuroligins;GABA synthesis, release, reuptake and degradation 6813 STXBP2 False True Platelet degranulation ;Other interleukin signaling 6829 SUPT5H False True Formation of RNA Pol II elongation complex ;Formation of the Early Elongation Complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of the HIV-1 Early Elongation Complex;RNA Pol II CTD phosphorylation and interaction with CE during HIV infection;Formation of HIV-1 elongation complex containing HIV-1 Tat;Formation of HIV-1 elongation complex containing HIV-1 Tat;Pausing and recovery of Tat-mediated HIV elongation;Abortive elongation of HIV-1 transcript in the absence of Tat;Tat-mediated HIV elongation arrest and recovery;Tat-mediated elongation of the HIV-1 transcript;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;RNA Polymerase II Pre-transcription Events;TP53 Regulates Transcription of DNA Repair Genes;RNA polymerase II transcribes snRNA genes;mRNA Capping;RNA Polymerase II Transcription Elongation;RNA Pol II CTD phosphorylation and interaction with CE 6835 SURF2 False True NA 6836 SURF4 False True Neutrophil degranulation;COPI-dependent Golgi-to-ER retrograde traffic 6840 SVIL False True NA 6843 VAMP1 False True Toxicity of botulinum toxin type D (BoNT/D);Toxicity of botulinum toxin type F (BoNT/F);Toxicity of botulinum toxin type G (BoNT/G) 6844 VAMP2 False True Translocation of SLC2A4 (GLUT4) to the plasma membrane;Serotonin Neurotransmitter Release Cycle;Norepinephrine Neurotransmitter Release Cycle;Glutamate Neurotransmitter Release Cycle;Dopamine Neurotransmitter Release Cycle;Acetylcholine Neurotransmitter Release Cycle;Insulin processing;Clathrin derived vesicle budding;Regulation of insulin secretion;Lysosome Vesicle Biogenesis;Golgi Associated Vesicle Biogenesis;Other interleukin signaling;Toxicity of botulinum toxin type D (BoNT/D);Toxicity of botulinum toxin type B (BoNT/B);Toxicity of botulinum toxin type F (BoNT/F);Toxicity of tetanus toxin (TeNT);Toxicity of botulinum toxin type G (BoNT/G);Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;GABA synthesis, release, reuptake and degradation 6856 SYPL1 False True NA 6867 TACC1 False True NA 6871 TADA2A False True HATs acetylate histones 6873 TAF2 False True HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;RNA Polymerase II Pre-transcription Events;Regulation of TP53 Activity through Phosphorylation;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance 6876 TAGLN False True NA 6885 MAP3K7 False True Activation of NF-kappaB in B cells;NOD1/2 Signaling Pathway;Downstream TCR signaling;FCERI mediated NF-kB activation;Ca2+ pathway;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;activated TAK1 mediates p38 MAPK activation;JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1;TNFR1-induced NFkappaB signaling pathway;CLEC7A (Dectin-1) signaling;Ub-specific processing proteases;TICAM1,TRAF6-dependent induction of TAK1 complex;Interleukin-1 signaling;IRAK2 mediated activation of TAK1 complex;TRAF6-mediated induction of TAK1 complex within TLR4 complex;IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 6888 TALDO1 False True Insulin effects increased synthesis of Xylulose-5-Phosphate;TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P;TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P;Pentose phosphate pathway;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 6890 TAP1 False True ER-Phagosome pathway;ER-Phagosome pathway;Antigen Presentation: Folding, assembly and peptide loading of class I MHC 6894 TARBP1 False True NA 6895 TARBP2 False True MicroRNA (miRNA) biogenesis;Small interfering RNA (siRNA) biogenesis 6897 TARS False True Cytosolic tRNA aminoacylation 6902 TBCA False True Post-chaperonin tubulin folding pathway 6905 TBCE False True Post-chaperonin tubulin folding pathway 6907 TBL1X False True RORA activates gene expression;BMAL1:CLOCK,NPAS2 activates circadian gene expression;PPARA activates gene expression;PPARA activates gene expression;NOTCH1 Intracellular Domain Regulates Transcription;Transcriptional activation of mitochondrial biogenesis;Activation of gene expression by SREBF (SREBP);Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;HDACs deacetylate histones;Transcriptional regulation of white adipocyte differentiation;Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha);Circadian Clock;Loss of MECP2 binding ability to the NCoR/SMRT complex;Regulation of MECP2 expression and activity 6908 TBP False True HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;SIRT1 negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;B-WICH complex positively regulates rRNA expression;RNA Polymerase II Pre-transcription Events;Regulation of TP53 Activity through Phosphorylation;RNA polymerase II transcribes snRNA genes;RNA polymerase II transcribes snRNA genes;RNA Polymerase I Transcription Initiation;RNA Polymerase I Transcription Initiation;RNA Polymerase I Promoter Escape;RNA Polymerase II Promoter Escape;RNA Polymerase I Chain Elongation;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase I Transcription Termination;RNA Polymerase III Abortive And Retractive Initiation;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance;RNA Polymerase III Transcription Initiation From Type 1 Promoter;RNA Polymerase III Transcription Initiation From Type 1 Promoter;RNA Polymerase III Transcription Initiation From Type 2 Promoter;RNA Polymerase III Transcription Initiation From Type 2 Promoter;RNA Polymerase III Transcription Initiation From Type 3 Promoter;RNA Polymerase III Transcription Initiation From Type 3 Promoter;Estrogen-dependent gene expression 6919 TCEA2 False True NA 6924 TCEB3 False True Formation of RNA Pol II elongation complex ;Formation of HIV elongation complex in the absence of HIV Tat;Formation of HIV-1 elongation complex containing HIV-1 Tat;Pausing and recovery of Tat-mediated HIV elongation;Tat-mediated HIV elongation arrest and recovery;Tat-mediated elongation of the HIV-1 transcript;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;RNA Polymerase II Pre-transcription Events;TP53 Regulates Transcription of DNA Repair Genes;RNA Polymerase II Transcription Elongation 6925 TCF4 False True CDO in myogenesis;CDO in myogenesis 6934 TCF7L2 False True Formation of the beta-catenin:TCF transactivating complex;Formation of the beta-catenin:TCF transactivating complex;Deactivation of the beta-catenin transactivating complex;Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1);Ca2+ pathway;Binding of TCF/LEF:CTNNB1 to target gene promoters;Repression of WNT target genes;Repression of WNT target genes;TCF7L2 mutants don't bind CTBP;RUNX3 regulates WNT signaling 6950 TCP1 False True Prefoldin mediated transfer of substrate to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Folding of actin by CCT/TriC;Association of TriC/CCT with target proteins during biosynthesis;Association of TriC/CCT with target proteins during biosynthesis;BBSome-mediated cargo-targeting to cilium;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 6999 TDO2 False True Tryptophan catabolism 7001 PRDX2 False True Detoxification of Reactive Oxygen Species;TP53 Regulates Metabolic Genes;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models 7013 TERF1 False True Meiotic synapsis;Packaging Of Telomere Ends;DNA Damage/Telomere Stress Induced Senescence 7014 TERF2 False True Meiotic synapsis;Packaging Of Telomere Ends;DNA Damage/Telomere Stress Induced Senescence 7015 TERT False True Telomere Extension By Telomerase;Formation of the beta-catenin:TCF transactivating complex 7016 TESK1 False True Regulation of cytoskeletal remodeling and cell spreading by IPP complex components 7018 TF True True Platelet degranulation ;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Post-translational protein phosphorylation;Iron uptake and transport;Transferrin endocytosis and recycling 7026 NR2F2 False True Transcriptional regulation of white adipocyte differentiation 7037 TFRC False True Golgi Associated Vesicle Biogenesis;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Transferrin endocytosis and recycling 7038 TG False True NA 7040 TGFB1 False True Platelet degranulation ;Influenza Virus Induced Apoptosis;Cell surface interactions at the vascular wall;Molecules associated with elastic fibres;Downregulation of TGF-beta receptor signaling;Downregulation of TGF-beta receptor signaling;TGF-beta receptor signaling activates SMADs;TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);Syndecan interactions;ECM proteoglycans;SMAD2/3 Phosphorylation Motif Mutants in Cancer;SMAD2/3 MH2 Domain Mutants in Cancer;TGFBR2 MSI Frameshift Mutants in Cancer;TGFBR2 Kinase Domain Mutants in Cancer;TGFBR1 KD Mutants in Cancer;TGFBR1 LBD Mutants in Cancer;Transcriptional regulation of white adipocyte differentiation;UCH proteinases;Interleukin-4 and Interleukin-13 signaling;RUNX3 regulates CDKN1A transcription;Regulation of RUNX3 expression and activity;RUNX3 regulates p14-ARF 7041 TGFB1I1 False True NA 7046 TGFBR1 False True Downregulation of TGF-beta receptor signaling;Downregulation of TGF-beta receptor signaling;TGF-beta receptor signaling activates SMADs;TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);SMAD2/3 Phosphorylation Motif Mutants in Cancer;SMAD2/3 MH2 Domain Mutants in Cancer;TGFBR2 Kinase Domain Mutants in Cancer;TGFBR1 KD Mutants in Cancer;TGFBR1 LBD Mutants in Cancer;UCH proteinases;Ub-specific processing proteases 7048 TGFBR2 False True Downregulation of TGF-beta receptor signaling;Downregulation of TGF-beta receptor signaling;TGF-beta receptor signaling activates SMADs;TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);SMAD2/3 Phosphorylation Motif Mutants in Cancer;SMAD2/3 MH2 Domain Mutants in Cancer;TGFBR2 MSI Frameshift Mutants in Cancer;TGFBR2 Kinase Domain Mutants in Cancer;TGFBR1 KD Mutants in Cancer;TGFBR1 LBD Mutants in Cancer;UCH proteinases 7052 TGM2 False True NA 7053 TGM3 True True NA 7056 THBD False True Common Pathway of Fibrin Clot Formation;Cell surface interactions at the vascular wall 7064 THOP1 False True Antigen processing: Ubiquitination & Proteasome degradation 7067 THRA False True Nuclear Receptor transcription pathway;SUMOylation of intracellular receptors 7073 TIAL1 False True FGFR2 alternative splicing 7074 TIAM1 False True NRAGE signals death through JNK;Rho GTPase cycle;EPHB-mediated forward signaling;EPH-ephrin mediated repulsion of cells;G alpha (12/13) signalling events;Activated NTRK2 signals through CDK5 7075 TIE1 False True NA 7082 TJP1 False True c-src mediated regulation of Cx43 function and closure of gap junctions;c-src mediated regulation of Cx43 function and closure of gap junctions;Signaling by Hippo;Apoptotic cleavage of cell adhesion proteins;RUNX1 regulates expression of components of tight junctions 7086 TKT False True Insulin effects increased synthesis of Xylulose-5-Phosphate;Pentose phosphate pathway 7094 TLN1 False True Platelet degranulation ;Integrin alphaIIb beta3 signaling;GRB2:SOS provides linkage to MAPK signaling for Integrins ;p130Cas linkage to MAPK signaling for integrins;XBP1(S) activates chaperone genes;SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion;Smooth Muscle Contraction;MAP2K and MAPK activation;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF 7102 NA False True Cell surface interactions at the vascular wall;Trafficking of GluR2-containing AMPA receptors 7105 TSPAN6 False True NA 7111 TMOD1 False True Striated Muscle Contraction 7112 TMPO False True Clearance of Nuclear Envelope Membranes from Chromatin;Initiation of Nuclear Envelope Reformation;Depolymerisation of the Nuclear Lamina 7114 TMSB4X False True Platelet degranulation 7124 TNF False True Transcriptional regulation of white adipocyte differentiation;TNFR1-induced proapoptotic signaling;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;TNFR1-mediated ceramide production;TNFR2 non-canonical NF-kB pathway;Interleukin-10 signaling;Interleukin-4 and Interleukin-13 signaling;TNF signaling 7126 TNFAIP1 False True NA 7128 TNFAIP3 False True NOD1/2 Signaling Pathway;TNFR1-induced proapoptotic signaling;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;Ovarian tumor domain proteases;Negative regulators of DDX58/IFIH1 signaling 7145 TNS1 False True NA 7150 TOP1 False True SUMOylation of DNA replication proteins 7153 TOP2A False True Transcription of E2F targets under negative control by DREAM complex;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins 7157 TP53 False True Activation of NOXA and translocation to mitochondria;Activation of PUMA and translocation to mitochondria;Pre-NOTCH Transcription and Translation;Oxidative Stress Induced Senescence;Formation of Senescence-Associated Heterochromatin Foci (SAHF);Oncogene Induced Senescence;DNA Damage/Telomere Stress Induced Senescence;SUMOylation of transcription factors;Autodegradation of the E3 ubiquitin ligase COP1;Association of TriC/CCT with target proteins during biosynthesis;TP53 Regulates Metabolic Genes;Ub-specific processing proteases;Ovarian tumor domain proteases;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Interleukin-4 and Interleukin-13 signaling;TP53 Regulates Transcription of DNA Repair Genes;TP53 Regulates Transcription of Genes Involved in Cytochrome C Release;TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain;TP53 Regulates Transcription of Caspase Activators and Caspases;TP53 Regulates Transcription of Death Receptors and Ligands;TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest;TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain;TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest;Regulation of TP53 Expression;Regulation of TP53 Activity through Phosphorylation;Regulation of TP53 Degradation;Regulation of TP53 Activity through Acetylation;Regulation of TP53 Activity through Association with Co-factors;Regulation of TP53 Activity through Methylation;PI5P Regulates TP53 Acetylation;G2/M DNA damage checkpoint;G2/M Checkpoints;Stabilization of p53;Transcriptional activation of cell cycle inhibitor p21 ;The role of GTSE1 in G2/M progression after G2 checkpoint;RUNX3 regulates CDKN1A transcription;Regulation of PTEN gene transcription;Regulation of PTEN gene transcription;Factors involved in megakaryocyte development and platelet production 7158 TP53BP1 False True SUMOylation of transcription factors;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Processing of DNA double-strand break ends;G2/M DNA damage checkpoint 7159 TP53BP2 False True Activation of PUMA and translocation to mitochondria;TP53 Regulates Transcription of Genes Involved in Cytochrome C Release;TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain;TP53 Regulates Transcription of Death Receptors and Ligands;Regulation of TP53 Activity through Association with Co-factors 7163 TPD52 False True Golgi Associated Vesicle Biogenesis 7165 TPD52L2 False True NA 7167 TPI1 True True Glycolysis;Gluconeogenesis 7168 TPM1 False True Striated Muscle Contraction;Smooth Muscle Contraction 7169 TPM2 False True Striated Muscle Contraction;Smooth Muscle Contraction 7170 TPM3 False True Striated Muscle Contraction;Smooth Muscle Contraction 7171 TPM4 False True Striated Muscle Contraction;Smooth Muscle Contraction 7175 TPR False True ISG15 antiviral mechanism;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Rev-mediated nuclear export of HIV RNA;Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Viral Messenger RNA Synthesis;NEP/NS2 Interacts with the Cellular Export Machinery;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;snRNP Assembly;SUMOylation of DNA damage response and repair proteins;SUMOylation of ubiquitinylation proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;SUMOylation of SUMOylation proteins;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins;Transcriptional regulation by small RNAs;Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC);tRNA processing in the nucleus 7178 TPT1 False True NA 7182 NR2C2 False True Nuclear Receptor transcription pathway 7184 HSP90B1 False True Trafficking and processing of endosomal TLR;Scavenging by Class A Receptors;Scavenging by Class A Receptors;ATF6 (ATF6-alpha) activates chaperone genes;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Interleukin-4 and Interleukin-13 signaling;Post-translational protein phosphorylation 7186 TRAF2 False True Caspase activation via Death Receptors in the presence of ligand;Regulation by c-FLIP;RIPK1-mediated regulated necrosis;CASP8 activity is inhibited;TNFR1-induced proapoptotic signaling;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;TNFR2 non-canonical NF-kB pathway;Regulation of necroptotic cell death;TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway;Ub-specific processing proteases;Dimerization of procaspase-8;TNF signaling;TRAF6 mediated IRF7 activation;TRAF6 mediated NF-kB activation;TRAF6 mediated NF-kB activation 7203 CCT3 False True Prefoldin mediated transfer of substrate to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Folding of actin by CCT/TriC;Association of TriC/CCT with target proteins during biosynthesis;Association of TriC/CCT with target proteins during biosynthesis;BBSome-mediated cargo-targeting to cilium;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 7204 TRIO False True NRAGE signals death through JNK;Rho GTPase cycle;G alpha (q) signalling events;G alpha (12/13) signalling events;DCC mediated attractive signaling;DCC mediated attractive signaling 7248 TSC1 False True Macroautophagy;Inhibition of TSC complex formation by PKB;Energy dependent regulation of mTOR by LKB1-AMPK;TP53 Regulates Metabolic Genes;TBC/RABGAPs 7249 TSC2 False True Macroautophagy;Inhibition of TSC complex formation by PKB;AKT phosphorylates targets in the cytosol;Energy dependent regulation of mTOR by LKB1-AMPK;TP53 Regulates Metabolic Genes;Constitutive Signaling by AKT1 E17K in Cancer;TBC/RABGAPs 7251 TSG101 False True Budding and maturation of HIV virion;Membrane binding and targetting of GAG proteins;Endosomal Sorting Complex Required For Transport (ESCRT) 7253 TSHR False True Hormone ligand-binding receptors;G alpha (s) signalling events 7265 TTC1 False True NA 7266 DNAJC7 False True Regulation of HSF1-mediated heat shock response 7267 TTC3 False True NA 7268 TTC4 False True NA 7272 TTK False True NA 7273 TTN False True Platelet degranulation ;Striated Muscle Contraction 7276 TTR False True Retinoid cycle disease events;The canonical retinoid cycle in rods (twilight vision);Non-integrin membrane-ECM interactions;Neutrophil degranulation;Retinoid metabolism and transport;Amyloid fiber formation 7277 TUBA4A False True Platelet degranulation ;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;Gap junction assembly;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;Regulation of PLK1 Activity at G2/M Transition;HSP90 chaperone cycle for steroid hormone receptors (SHR);Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Prefoldin mediated transfer of substrate to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Post-chaperonin tubulin folding pathway;Recycling pathway of L1;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Anchoring of the basal body to the plasma membrane;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;AURKA Activation by TPX2;Carboxyterminal post-translational modifications of tubulin;Carboxyterminal post-translational modifications of tubulin;Activation of AMPK downstream of NMDARs;Kinesins 7278 TUBA3C False True Translocation of SLC2A4 (GLUT4) to the plasma membrane;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;Gap junction assembly;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HSP90 chaperone cycle for steroid hormone receptors (SHR);Recruitment of NuMA to mitotic centrosomes;Prefoldin mediated transfer of substrate to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Post-chaperonin tubulin folding pathway;Recycling pathway of L1;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;Carboxyterminal post-translational modifications of tubulin;Carboxyterminal post-translational modifications of tubulin;Activation of AMPK downstream of NMDARs;Kinesins 7280 TUBB2A False True Translocation of SLC2A4 (GLUT4) to the plasma membrane;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;Gap junction assembly;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HSP90 chaperone cycle for steroid hormone receptors (SHR);Recruitment of NuMA to mitotic centrosomes;Prefoldin mediated transfer of substrate to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Post-chaperonin tubulin folding pathway;Recycling pathway of L1;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;Carboxyterminal post-translational modifications of tubulin;Carboxyterminal post-translational modifications of tubulin;Activation of AMPK downstream of NMDARs;Kinesins 7283 TUBG1 False True Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;AURKA Activation by TPX2 7284 TUFM False True Mitochondrial translation elongation 7295 TXN True True Oxidative Stress Induced Senescence;Detoxification of Reactive Oxygen Species;Interconversion of nucleotide di- and triphosphates;TP53 Regulates Metabolic Genes;Protein repair;The NLRP3 inflammasome;The NLRP3 inflammasome;Regulation of FOXO transcriptional activity by acetylation 7296 TXNRD1 False True PPARA activates gene expression;Metabolism of ingested H2SeO4 and H2SeO3 into H2Se;Detoxification of Reactive Oxygen Species;Interconversion of nucleotide di- and triphosphates;Metabolism of ingested MeSeO2H into MeSeH;Uptake and function of diphtheria toxin;TP53 Regulates Metabolic Genes 7297 TYK2 False True Interleukin-6 signaling;Interleukin-6 signaling;MAPK3 (ERK1) activation;MAPK1 (ERK2) activation;Other interleukin signaling;Interleukin-10 signaling;Interleukin-4 and Interleukin-13 signaling;IL-6-type cytokine receptor ligand interactions;Interleukin-20 family signaling;Interleukin-35 Signalling;Interleukin-12 signaling;Interleukin-12 signaling;Interleukin-23 signaling;Interleukin-23 signaling;Interleukin-27 signaling;Interleukin-27 signaling;Interferon alpha/beta signaling;Regulation of IFNA signaling;Regulation of IFNA signaling 7298 TYMS False True Interconversion of nucleotide di- and triphosphates;Activation of E2F1 target genes at G1/S 7301 TYRO3 False True NA 7307 U2AF1 False True Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing 7311 UBA52 True True Translesion synthesis by REV1;Recognition of DNA damage by PCNA-containing replication complex;Translesion Synthesis by POLH;Activation of NF-kappaB in B cells;ISG15 antiviral mechanism;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants;ER-Phagosome pathway;Downregulation of ERBB4 signaling;Spry regulation of FGF signaling;Downregulation of ERBB2:ERBB3 signaling;L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;Budding and maturation of HIV virion;NOD1/2 Signaling Pathway;TICAM1, RIP1-mediated IKK complex recruitment ;DDX58/IFIH1-mediated induction of interferon-alpha/beta;APC/C:Cdc20 mediated degradation of Cyclin B;Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Membrane binding and targetting of GAG proteins;Assembly Of The HIV Virion;APC-Cdc20 mediated degradation of Nek2A;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;EGFR downregulation;SCF(Skp2)-mediated degradation of p27/p21;Viral mRNA Translation;Degradation of beta-catenin by the destruction complex;TCF dependent signaling in response to WNT;Downstream TCR signaling;NRIF signals cell death from the nucleus;p75NTR recruits signalling complexes;NF-kB is activated and signals survival;Regulation of activated PAK-2p34 by proteasome mediated degradation;NOTCH1 Intracellular Domain Regulates Transcription;Activated NOTCH1 Transmits Signal to the Nucleus;Activated NOTCH1 Transmits Signal to the Nucleus;Downregulation of TGF-beta receptor signaling;Downregulation of TGF-beta receptor signaling;TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);Downregulation of SMAD2/3:SMAD4 transcriptional activity;Downregulation of SMAD2/3:SMAD4 transcriptional activity;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;Selenocysteine synthesis;Separation of Sister Chromatids;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);Oncogene Induced Senescence;Regulation of PLK1 Activity at G2/M Transition;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Stimuli-sensing channels;Constitutive Signaling by NOTCH1 HD Domain Mutants;FCERI mediated NF-kB activation;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;NOTCH2 Activation and Transmission of Signal to the Nucleus;Regulation of innate immune responses to cytosolic DNA;Glycogen synthesis;Autodegradation of the E3 ubiquitin ligase COP1;Deactivation of the beta-catenin transactivating complex;Myoclonic epilepsy of Lafora;ABC-family proteins mediated transport;Circadian Clock;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;activated TAK1 mediates p38 MAPK activation;JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Regulation of FZD by ubiquitination;Pink/Parkin Mediated Mitophagy;N-glycan trimming in the ER and Calnexin/Calreticulin cycle;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Hedgehog 'on' state;Negative regulation of FGFR1 signaling;Negative regulation of FGFR2 signaling;Negative regulation of FGFR3 signaling;Negative regulation of FGFR4 signaling;Translesion synthesis by POLK;Translesion synthesis by POLI;Termination of translesion DNA synthesis;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;Negative regulation of MAPK pathway;Regulation of necroptotic cell death;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAP3K8 (TPL2)-dependent MAPK1/3 activation;HDR through Homologous Recombination (HRR);MAPK6/MAPK4 signaling;UCH proteinases;UCH proteinases;Josephin domain DUBs;Ub-specific processing proteases;Ovarian tumor domain proteases;Metalloprotease DUBs;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Processing of DNA double-strand break ends;DNA Damage Recognition in GG-NER;Formation of Incision Complex in GG-NER;Gap-filling DNA repair synthesis and ligation in GG-NER;Dual Incision in GG-NER;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Fanconi Anemia Pathway;Major pathway of rRNA processing in the nucleolus and cytosol;Regulation of TP53 Activity through Phosphorylation;Regulation of TP53 Degradation;Regulation of TP53 Activity through Methylation;Negative regulation of MET activity;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;Cyclin D associated events in G1;G2/M Checkpoints;Stabilization of p53;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Downregulation of ERBB2 signaling;Synthesis of active ubiquitin: roles of E1 and E2 enzymes;Synthesis of active ubiquitin: roles of E1 and E2 enzymes;E3 ubiquitin ligases ubiquitinate target proteins;InlB-mediated entry of Listeria monocytogenes into host cell;InlA-mediated entry of Listeria monocytogenes into host cells;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN localization;Regulation of PTEN stability and activity;Neddylation;ER Quality Control Compartment (ERQC);Regulation of expression of SLITs and ROBOs;Regulation of expression of SLITs and ROBOs;NOTCH3 Activation and Transmission of Signal to the Nucleus;NOTCH3 Activation and Transmission of Signal to the Nucleus;TICAM1-dependent activation of IRF3/IRF7;TICAM1,TRAF6-dependent induction of TAK1 complex;Interleukin-1 signaling;Peroxisomal protein import;Peroxisomal protein import;Regulation of signaling by CBL;Endosomal Sorting Complex Required For Transport (ESCRT);Iron uptake and transport;Negative regulators of DDX58/IFIH1 signaling;Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon;IRAK1 recruits IKK complex;IKK complex recruitment mediated by RIP1;IRAK2 mediated activation of TAK1 complex;TRAF6-mediated induction of TAK1 complex within TLR4 complex;Negative regulation of NOTCH4 signaling;TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling;IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation;IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC);Amyloid fiber formation;Antigen processing: Ubiquitination & Proteasome degradation 7316 UBC False True Translesion synthesis by REV1;Recognition of DNA damage by PCNA-containing replication complex;Translesion Synthesis by POLH;Activation of NF-kappaB in B cells;ISG15 antiviral mechanism;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants;ER-Phagosome pathway;Downregulation of ERBB4 signaling;Spry regulation of FGF signaling;Downregulation of ERBB2:ERBB3 signaling;Budding and maturation of HIV virion;NOD1/2 Signaling Pathway;TICAM1, RIP1-mediated IKK complex recruitment ;DDX58/IFIH1-mediated induction of interferon-alpha/beta;APC/C:Cdc20 mediated degradation of Cyclin B;Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Membrane binding and targetting of GAG proteins;Assembly Of The HIV Virion;APC-Cdc20 mediated degradation of Nek2A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;EGFR downregulation;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;TCF dependent signaling in response to WNT;Downstream TCR signaling;NRIF signals cell death from the nucleus;p75NTR recruits signalling complexes;NF-kB is activated and signals survival;Regulation of activated PAK-2p34 by proteasome mediated degradation;NOTCH1 Intracellular Domain Regulates Transcription;Activated NOTCH1 Transmits Signal to the Nucleus;Activated NOTCH1 Transmits Signal to the Nucleus;Downregulation of TGF-beta receptor signaling;Downregulation of TGF-beta receptor signaling;TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);Downregulation of SMAD2/3:SMAD4 transcriptional activity;Downregulation of SMAD2/3:SMAD4 transcriptional activity;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;Separation of Sister Chromatids;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);Oncogene Induced Senescence;Regulation of PLK1 Activity at G2/M Transition;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Stimuli-sensing channels;Constitutive Signaling by NOTCH1 HD Domain Mutants;FCERI mediated NF-kB activation;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;NOTCH2 Activation and Transmission of Signal to the Nucleus;Regulation of innate immune responses to cytosolic DNA;Glycogen synthesis;Autodegradation of the E3 ubiquitin ligase COP1;Deactivation of the beta-catenin transactivating complex;Myoclonic epilepsy of Lafora;ABC-family proteins mediated transport;Circadian Clock;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;activated TAK1 mediates p38 MAPK activation;JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Regulation of FZD by ubiquitination;Pink/Parkin Mediated Mitophagy;N-glycan trimming in the ER and Calnexin/Calreticulin cycle;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Hedgehog 'on' state;Negative regulation of FGFR1 signaling;Negative regulation of FGFR2 signaling;Negative regulation of FGFR3 signaling;Negative regulation of FGFR4 signaling;Translesion synthesis by POLK;Translesion synthesis by POLI;Termination of translesion DNA synthesis;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;Negative regulation of MAPK pathway;Regulation of necroptotic cell death;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAP3K8 (TPL2)-dependent MAPK1/3 activation;HDR through Homologous Recombination (HRR);MAPK6/MAPK4 signaling;UCH proteinases;UCH proteinases;Josephin domain DUBs;Ub-specific processing proteases;Ovarian tumor domain proteases;Metalloprotease DUBs;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Processing of DNA double-strand break ends;DNA Damage Recognition in GG-NER;Formation of Incision Complex in GG-NER;Gap-filling DNA repair synthesis and ligation in GG-NER;Dual Incision in GG-NER;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Fanconi Anemia Pathway;Regulation of TP53 Activity through Phosphorylation;Regulation of TP53 Degradation;Regulation of TP53 Activity through Methylation;Negative regulation of MET activity;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;Cyclin D associated events in G1;G2/M Checkpoints;Stabilization of p53;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Downregulation of ERBB2 signaling;Synthesis of active ubiquitin: roles of E1 and E2 enzymes;Synthesis of active ubiquitin: roles of E1 and E2 enzymes;E3 ubiquitin ligases ubiquitinate target proteins;InlB-mediated entry of Listeria monocytogenes into host cell;InlA-mediated entry of Listeria monocytogenes into host cells;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN localization;Regulation of PTEN stability and activity;Neddylation;ER Quality Control Compartment (ERQC);Regulation of expression of SLITs and ROBOs;Regulation of expression of SLITs and ROBOs;NOTCH3 Activation and Transmission of Signal to the Nucleus;NOTCH3 Activation and Transmission of Signal to the Nucleus;TICAM1-dependent activation of IRF3/IRF7;TICAM1,TRAF6-dependent induction of TAK1 complex;Interleukin-1 signaling;Peroxisomal protein import;Peroxisomal protein import;Regulation of signaling by CBL;Endosomal Sorting Complex Required For Transport (ESCRT);Iron uptake and transport;Negative regulators of DDX58/IFIH1 signaling;Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon;IRAK1 recruits IKK complex;IKK complex recruitment mediated by RIP1;IRAK2 mediated activation of TAK1 complex;TRAF6-mediated induction of TAK1 complex within TLR4 complex;Negative regulation of NOTCH4 signaling;TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling;IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation;IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation;Amyloid fiber formation;Antigen processing: Ubiquitination & Proteasome degradation 7317 UBA1 False True Synthesis of active ubiquitin: roles of E1 and E2 enzymes;Antigen processing: Ubiquitination & Proteasome degradation 7321 UBE2D1 False True Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Inactivation of APC/C via direct inhibition of the APC/C complex;TICAM1, RIP1-mediated IKK complex recruitment ;APC/C:Cdc20 mediated degradation of Cyclin B;Autodegradation of Cdh1 by Cdh1:APC/C;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase;Regulation of APC/C activators between G1/S and early anaphase;APC/C:Cdc20 mediated degradation of mitotic proteins;Phosphorylation of the APC/C;APC-Cdc20 mediated degradation of Nek2A;Signaling by BMP;Downstream TCR signaling;Downregulation of SMAD2/3:SMAD4 transcriptional activity;Separation of Sister Chromatids;Senescence-Associated Secretory Phenotype (SASP);FCERI mediated NF-kB activation;CLEC7A (Dectin-1) signaling;Ovarian tumor domain proteases;CDK-mediated phosphorylation and removal of Cdc6;Synthesis of active ubiquitin: roles of E1 and E2 enzymes;E3 ubiquitin ligases ubiquitinate target proteins;Neddylation;Peroxisomal protein import;Negative regulators of DDX58/IFIH1 signaling;IKK complex recruitment mediated by RIP1;Antigen processing: Ubiquitination & Proteasome degradation 7322 UBE2D2 False True Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;TICAM1, RIP1-mediated IKK complex recruitment ;Downstream TCR signaling;FCERI mediated NF-kB activation;CLEC7A (Dectin-1) signaling;Synthesis of active ubiquitin: roles of E1 and E2 enzymes;E3 ubiquitin ligases ubiquitinate target proteins;Neddylation;Peroxisomal protein import;Negative regulators of DDX58/IFIH1 signaling;IKK complex recruitment mediated by RIP1;Antigen processing: Ubiquitination & Proteasome degradation 7328 UBE2H False True Synthesis of active ubiquitin: roles of E1 and E2 enzymes;Antigen processing: Ubiquitination & Proteasome degradation 7329 UBE2I False True Meiotic synapsis;Vitamin D (calciferol) metabolism;SUMO is transferred from E1 to E2 (UBE2I, UBC9);SUMO is transferred from E1 to E2 (UBE2I, UBC9);SUMOylation of DNA damage response and repair proteins;SUMOylation of transcription factors;SUMOylation of transcription factors;SUMOylation of ubiquitinylation proteins;SUMOylation of transcription cofactors;SUMOylation of transcription cofactors;SUMOylation of SUMOylation proteins;SUMOylation of intracellular receptors;SUMOylation of intracellular receptors;SUMOylation of chromatin organization proteins;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA methylation proteins;SUMOylation of DNA methylation proteins;SUMOylation of immune response proteins;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Processing of DNA double-strand break ends;Formation of Incision Complex in GG-NER;Negative regulation of activity of TFAP2 (AP-2) family transcription factors;Negative regulation of activity of TFAP2 (AP-2) family transcription factors 7332 UBE2L3 False True Synthesis of active ubiquitin: roles of E1 and E2 enzymes;E3 ubiquitin ligases ubiquitinate target proteins;Antigen processing: Ubiquitination & Proteasome degradation 7334 UBE2N False True ISG15 antiviral mechanism;NOD1/2 Signaling Pathway;TICAM1, RIP1-mediated IKK complex recruitment ;Downstream TCR signaling;FCERI mediated NF-kB activation;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;activated TAK1 mediates p38 MAPK activation;JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1;CLEC7A (Dectin-1) signaling;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Processing of DNA double-strand break ends;Formation of Incision Complex in GG-NER;G2/M DNA damage checkpoint;E3 ubiquitin ligases ubiquitinate target proteins;Interleukin-1 signaling;IRAK1 recruits IKK complex;IKK complex recruitment mediated by RIP1;TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling;IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation;Antigen processing: Ubiquitination & Proteasome degradation 7335 UBE2V1 False True NOD1/2 Signaling Pathway;TICAM1, RIP1-mediated IKK complex recruitment ;Downstream TCR signaling;FCERI mediated NF-kB activation;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;activated TAK1 mediates p38 MAPK activation;JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1;CLEC7A (Dectin-1) signaling;Interleukin-1 signaling;IRAK1 recruits IKK complex;IKK complex recruitment mediated by RIP1;TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling;IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation;Antigen processing: Ubiquitination & Proteasome degradation 7337 UBE3A False True Antigen processing: Ubiquitination & Proteasome degradation 7341 SUMO1 False True SUMO is conjugated to E1 (UBA2:SAE1);SUMO is transferred from E1 to E2 (UBE2I, UBC9);SUMO is proteolytically processed;SUMOylation of DNA damage response and repair proteins;SUMOylation of transcription factors;SUMOylation of transcription factors;SUMOylation of ubiquitinylation proteins;SUMOylation of transcription cofactors;SUMOylation of transcription cofactors;SUMOylation of SUMOylation proteins;SUMOylation of intracellular receptors;SUMOylation of intracellular receptors;SUMOylation of chromatin organization proteins;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA methylation proteins;SUMOylation of DNA methylation proteins;SUMOylation of immune response proteins;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Processing of DNA double-strand break ends;Formation of Incision Complex in GG-NER;G2/M DNA damage checkpoint;Regulation of IFNG signaling;Negative regulation of activity of TFAP2 (AP-2) family transcription factors;Negative regulation of activity of TFAP2 (AP-2) family transcription factors 7343 UBTF False True NoRC negatively regulates rRNA expression;RNA Polymerase I Promoter Opening;RNA Polymerase I Transcription Initiation;RNA Polymerase I Promoter Escape;RNA Polymerase I Chain Elongation;RNA Polymerase I Transcription Termination 7345 UCHL1 False True UCH proteinases 7347 UCHL3 False True UCH proteinases;Synthesis of active ubiquitin: roles of E1 and E2 enzymes;Neddylation 7348 UPK1B False True NA 7353 UFD1L False True Translesion Synthesis by POLH;Ub-specific processing proteases 7358 UGDH False True Formation of the active cofactor, UDP-glucuronate 7372 UMPS False True Pyrimidine biosynthesis 7374 UNG False True Recognition and association of DNA glycosylase with site containing an affected pyrimidine;Cleavage of the damaged pyrimidine ;Displacement of DNA glycosylase by APEX1 7375 USP4 False True TNFR1-induced proapoptotic signaling;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;Ub-specific processing proteases 7381 UQCRB False True Respiratory electron transport 7384 UQCRC1 False True Respiratory electron transport 7385 UQCRC2 False True Respiratory electron transport 7386 UQCRFS1 False True Respiratory electron transport 7405 UVRAG False True Macroautophagy 7407 VARS False True Cytosolic tRNA aminoacylation 7408 VASP False True Generation of second messenger molecules;Signaling by ROBO receptors;Signaling by ROBO receptors;Cell-extracellular matrix interactions 7411 VBP1 False True Prefoldin mediated transfer of substrate to CCT/TriC 7414 VCL True True Platelet degranulation ;Smooth Muscle Contraction;MAP2K and MAPK activation;Neutrophil degranulation;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF 7415 VCP False True Translesion Synthesis by POLH;HSF1 activation;ABC-family proteins mediated transport;N-glycan trimming in the ER and Calnexin/Calreticulin cycle;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Defective CFTR causes cystic fibrosis;Josephin domain DUBs;Ovarian tumor domain proteases;Neutrophil degranulation;E3 ubiquitin ligases ubiquitinate target proteins;Protein methylation 7416 VDAC1 False True Mitochondrial protein import;Pink/Parkin Mediated Mitophagy;Ub-specific processing proteases;Pyruvate metabolism;Mitochondrial calcium ion transport 7417 VDAC2 False True Ub-specific processing proteases;Mitochondrial calcium ion transport 7419 VDAC3 False True Ub-specific processing proteases;Mitochondrial calcium ion transport 7421 VDR False True Vitamin D (calciferol) metabolism;Nuclear Receptor transcription pathway;SUMOylation of intracellular receptors 7428 VHL False True Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;SUMOylation of ubiquitinylation proteins;Neddylation;Antigen processing: Ubiquitination & Proteasome degradation 7430 EZR False True Netrin-1 signaling;Recycling pathway of L1;Recycling pathway of L1 7431 VIM False True Caspase-mediated cleavage of cytoskeletal proteins;Striated Muscle Contraction;Interleukin-4 and Interleukin-13 signaling 7443 VRK1 False True Clearance of Nuclear Envelope Membranes from Chromatin;Initiation of Nuclear Envelope Reformation 7444 VRK2 False True Clearance of Nuclear Envelope Membranes from Chromatin;Initiation of Nuclear Envelope Reformation 7448 VTN False True Molecules associated with elastic fibres;Integrin cell surface interactions;Syndecan interactions;ECM proteoglycans;ECM proteoglycans;Regulation of Complement cascade 7453 WARS False True Cytosolic tRNA aminoacylation 7458 EIF4H False True L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit 7464 CORO2A False True NA 7465 WEE1 False True Polo-like kinase mediated events;Cyclin E associated events during G1/S transition ;Cyclin A/B1/B2 associated events during G2/M transition;Cyclin A/B1/B2 associated events during G2/M transition;G2/M DNA replication checkpoint;Cyclin A:Cdk2-associated events at S phase entry;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;Factors involved in megakaryocyte development and platelet production 7466 WFS1 False True XBP1(S) activates chaperone genes;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation 7514 XPO1 False True Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Rev-mediated nuclear export of HIV RNA;NEP/NS2 Interacts with the Cellular Export Machinery;Downregulation of TGF-beta receptor signaling;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;Deactivation of the beta-catenin transactivating complex;HuR (ELAVL1) binds and stabilizes mRNA;RHO GTPases Activate Formins;MAPK6/MAPK4 signaling;Mitotic Prometaphase;Cyclin A/B1/B2 associated events during G2/M transition 7515 XRCC1 False True Resolution of AP sites via the single-nucleotide replacement pathway;APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway;HDR through MMEJ (alt-NHEJ);Gap-filling DNA repair synthesis and ligation in GG-NER;Gap-filling DNA repair synthesis and ligation in TC-NER 7517 XRCC3 False True HDR through Homologous Recombination (HRR);Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA);Resolution of D-loop Structures through Holliday Junction Intermediates;Homologous DNA Pairing and Strand Exchange 7520 XRCC5 False True 2-LTR circle formation;Cytosolic sensors of pathogen-associated DNA ;IRF3-mediated induction of type I IFN;Nonhomologous End-Joining (NHEJ);Neutrophil degranulation 7525 YES1 False True Signaling by ERBB2;Signaling by SCF-KIT;Signaling by SCF-KIT;Regulation of KIT signaling;FCGR activation;PECAM1 interactions;EPH-Ephrin signaling;CD28 co-stimulation;CTLA4 inhibitory signaling;EPHB-mediated forward signaling;EPHB-mediated forward signaling;EPHA-mediated growth cone collapse;EPHA-mediated growth cone collapse;EPH-ephrin mediated repulsion of cells;RUNX2 regulates osteoblast differentiation;Regulation of signaling by CBL;Regulation of signaling by CBL 7529 YWHAB False True Activation of BAD and translocation to mitochondria ;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Translocation of SLC2A4 (GLUT4) to the plasma membrane;mTOR signalling;mTORC1-mediated signalling;Frs2-mediated activation;ARMS-mediated activation;Signaling by Hippo;Rap1 signalling;Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA;Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA;RHO GTPases activate PKNs;TP53 Regulates Metabolic Genes;RAF activation;MAP2K and MAPK activation;Negative regulation of MAPK pathway;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;Regulation of localization of FOXO transcription factors 7531 YWHAE True True Activation of BAD and translocation to mitochondria ;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Signaling by Hippo;NADE modulates death signalling;Regulation of PLK1 Activity at G2/M Transition;Regulation of HSF1-mediated heat shock response;HSF1 activation;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;RHO GTPases activate PKNs;TP53 Regulates Metabolic Genes;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;AURKA Activation by TPX2;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;RAB GEFs exchange GTP for GDP on RABs 7532 YWHAG False True Activation of BAD and translocation to mitochondria ;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;RHO GTPases activate PKNs;TP53 Regulates Metabolic Genes;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;AURKA Activation by TPX2;Regulation of localization of FOXO transcription factors 7533 YWHAH False True Activation of BAD and translocation to mitochondria ;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Translocation of SLC2A4 (GLUT4) to the plasma membrane;RHO GTPases activate PKNs;TP53 Regulates Metabolic Genes;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 7534 YWHAZ True True Activation of BAD and translocation to mitochondria ;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Deactivation of the beta-catenin transactivating complex;Rap1 signalling;GP1b-IX-V activation signalling;KSRP (KHSRP) binds and destabilizes mRNA;Interleukin-3, Interleukin-5 and GM-CSF signaling;RHO GTPases activate PKNs;TP53 Regulates Metabolic Genes;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;NOTCH4 Activation and Transmission of Signal to the Nucleus;Negative regulation of NOTCH4 signaling;Regulation of localization of FOXO transcription factors 7535 ZAP70 False True Translocation of ZAP-70 to Immunological synapse;Generation of second messenger molecules 7536 SF1 False True mRNA Splicing - Major Pathway 7542 ZFPL1 False True NA 7551 ZNF3 False True Generic Transcription Pathway 7597 ZBTB25 False True NA 7620 ZNF69 False True NA 7625 ZNF74 False True Generic Transcription Pathway 7675 NA False True NA 7681 MKRN3 False True NA 7690 ZNF131 False True SUMOylation of transcription cofactors 7697 ZNF138 False True Generic Transcription Pathway 7705 NA False True NA 7709 ZBTB17 False True XBP1(S) activates chaperone genes 7726 TRIM26 False True Interferon gamma signaling 7737 RNF113A False True NA 7762 NA False True Generic Transcription Pathway 7775 ZNF232 False True NA 7780 SLC30A2 False True Zinc efflux and compartmentalization by the SLC30 family 7781 SLC30A3 False True Zinc efflux and compartmentalization by the SLC30 family 7786 MAP3K12 False True NA 7791 ZYX False True NA 7798 NA False True NA 7803 PTP4A1 False True NA 7812 CSDE1 False True NA 7818 DAP3 False True Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation elongation;Mitochondrial translation termination 7846 TUBA1A False True Translocation of SLC2A4 (GLUT4) to the plasma membrane;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;Gap junction assembly;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;Regulation of PLK1 Activity at G2/M Transition;HSP90 chaperone cycle for steroid hormone receptors (SHR);Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Prefoldin mediated transfer of substrate to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Post-chaperonin tubulin folding pathway;Recycling pathway of L1;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Anchoring of the basal body to the plasma membrane;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;AURKA Activation by TPX2;Carboxyterminal post-translational modifications of tubulin;Carboxyterminal post-translational modifications of tubulin;Activation of AMPK downstream of NMDARs;Kinesins 7851 MALL False True NA 7866 IFRD2 False True NA 7867 MAPKAPK3 False True p38MAPK events;Oxidative Stress Induced Senescence;VEGFA-VEGFR2 Pathway;activated TAK1 mediates p38 MAPK activation 7871 SLMAP False True NA 7874 USP7 False True Ub-specific processing proteases;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Regulation of TP53 Degradation;Synthesis of active ubiquitin: roles of E1 and E2 enzymes;Regulation of PTEN localization 7879 RAB7A False True MHC class II antigen presentation;Neutrophil degranulation;TBC/RABGAPs;RAB geranylgeranylation;RAB GEFs exchange GTP for GDP on RABs 7913 DEK False True B-WICH complex positively regulates rRNA expression;Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 7915 ALDH5A1 False True Degradation of GABA 7916 PRRC2A False True NA 7917 BAG6 False True NA 7919 DDX39B False True Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA 3'-end processing 7936 NELFE False True Formation of RNA Pol II elongation complex ;Formation of the Early Elongation Complex;Formation of HIV elongation complex in the absence of HIV Tat;Formation of the HIV-1 Early Elongation Complex;Formation of HIV-1 elongation complex containing HIV-1 Tat;Formation of HIV-1 elongation complex containing HIV-1 Tat;Pausing and recovery of Tat-mediated HIV elongation;Abortive elongation of HIV-1 transcript in the absence of Tat;Tat-mediated HIV elongation arrest and recovery;Tat-mediated elongation of the HIV-1 transcript;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;RNA Polymerase II Pre-transcription Events;TP53 Regulates Transcription of DNA Repair Genes;RNA Polymerase II Transcription Elongation 7957 EPM2A False True Glycogen synthesis;Myoclonic epilepsy of Lafora 7984 ARHGEF5 False True NRAGE signals death through JNK;Rho GTPase cycle;G alpha (12/13) signalling events 8021 NUP214 False True ISG15 antiviral mechanism;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Rev-mediated nuclear export of HIV RNA;Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Viral Messenger RNA Synthesis;NEP/NS2 Interacts with the Cellular Export Machinery;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;snRNP Assembly;SUMOylation of DNA damage response and repair proteins;SUMOylation of ubiquitinylation proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;SUMOylation of SUMOylation proteins;HuR (ELAVL1) binds and stabilizes mRNA;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins;Transcriptional regulation by small RNAs;tRNA processing in the nucleus 8027 STAM False True EGFR downregulation;Metalloprotease DUBs;Negative regulation of MET activity;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;InlB-mediated entry of Listeria monocytogenes into host cell;Endosomal Sorting Complex Required For Transport (ESCRT) 8078 USP5 False True Ub-specific processing proteases;Synthesis of active ubiquitin: roles of E1 and E2 enzymes 8079 MLF2 False True NA 8086 AAAS False True ISG15 antiviral mechanism;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Rev-mediated nuclear export of HIV RNA;Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Viral Messenger RNA Synthesis;NEP/NS2 Interacts with the Cellular Export Machinery;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;snRNP Assembly;SUMOylation of DNA damage response and repair proteins;SUMOylation of ubiquitinylation proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;SUMOylation of SUMOylation proteins;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins;Transcriptional regulation by small RNAs;tRNA processing in the nucleus 8087 FXR1 False True Signaling by BRAF and RAF fusions 8106 PABPN1 False True Cleavage of Growing Transcript in the Termination Region ;Inhibition of Host mRNA Processing and RNA Silencing;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Processing of Intronless Pre-mRNAs 8125 ANP32A False True HuR (ELAVL1) binds and stabilizes mRNA 8131 NPRL3 False True NA 8139 GAN False True Neddylation;Antigen processing: Ubiquitination & Proteasome degradation 8148 TAF15 False True HIV Transcription Initiation;RNA Polymerase II HIV Promoter Escape;Transcription of the HIV genome;RNA Polymerase II Pre-transcription Events;Regulation of TP53 Activity through Phosphorylation;RNA Polymerase II Promoter Escape;RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;RNA Polymerase II Transcription Initiation;RNA Polymerase II Transcription Initiation And Promoter Clearance 8175 SF3A2 False True mRNA Splicing - Major Pathway 8187 ZNF239 False True NA 8189 SYMPK False True Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA Derived from an Intronless Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Processing of Intronless Pre-mRNAs 8195 MKKS False True BBSome-mediated cargo-targeting to cilium 8202 NCOA3 False True PPARA activates gene expression;Transcriptional regulation of white adipocyte differentiation;Transcriptional regulation of white adipocyte differentiation;Activation of anterior HOX genes in hindbrain development during early embryogenesis;MAPK6/MAPK4 signaling;Estrogen-dependent gene expression 8218 CLTCL1 False True Gap junction degradation;Formation of annular gap junctions;EPH-ephrin mediated repulsion of cells;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis 8220 DGCR14 False True NA 8239 USP9X False True Downregulation of SMAD2/3:SMAD4 transcriptional activity;Ub-specific processing proteases;Synthesis of active ubiquitin: roles of E1 and E2 enzymes;Peroxisomal protein import;Peroxisomal protein import;Amyloid fiber formation 8241 RBM10 False True NA 8243 SMC1A False True Meiotic synapsis;Separation of Sister Chromatids;Establishment of Sister Chromatid Cohesion;Cohesin Loading onto Chromatin;Resolution of Sister Chromatid Cohesion;SUMOylation of DNA damage response and repair proteins;Estrogen-dependent gene expression 8266 UBL4A False True NA 8270 LAGE3 False True tRNA modification in the nucleus and cytosol 8294 HIST1H4I False True Meiotic synapsis;Packaging Of Telomere Ends;Pre-NOTCH Transcription and Translation;Formation of the beta-catenin:TCF transactivating complex;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;HDACs deacetylate histones;PKMTs methylate histone lysines;HDMs demethylate histones;HATs acetylate histones;HATs acetylate histones;RMTs methylate histone arginines;SIRT1 negatively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;NoRC negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;SUMOylation of chromatin organization proteins;B-WICH complex positively regulates rRNA expression;DNA methylation;Transcriptional regulation by small RNAs;Activation of anterior HOX genes in hindbrain development during early embryogenesis;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Processing of DNA double-strand break ends;Deposition of new CENPA-containing nucleosomes at the centromere;G2/M DNA damage checkpoint;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Estrogen-dependent gene expression;Meiotic recombination;Amyloid fiber formation 8301 PICALM False True Golgi Associated Vesicle Biogenesis;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis 8315 BRAP False True RAF activation;Negative regulation of MAPK pathway;Signaling by moderate kinase activity BRAF mutants;Signaling by RAS mutants;Paradoxical activation of RAF signaling by kinase inactive BRAF 8318 CDC45 False True Activation of ATR in response to replication stress;Unwinding of DNA;Activation of E2F1 target genes at G1/S;Activation of the pre-replicative complex 8324 FZD7 False True Class B/2 (Secretin family receptors);PCP/CE pathway;PCP/CE pathway;Asymmetric localization of PCP proteins 8335 HIST1H2AB False True Meiotic synapsis;Packaging Of Telomere Ends;Pre-NOTCH Transcription and Translation;Formation of the beta-catenin:TCF transactivating complex;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;HDACs deacetylate histones;HATs acetylate histones;HATs acetylate histones;RMTs methylate histone arginines;SIRT1 negatively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;NoRC negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;B-WICH complex positively regulates rRNA expression;DNA methylation;Transcriptional regulation by small RNAs;Activation of anterior HOX genes in hindbrain development during early embryogenesis;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;UCH proteinases;Ub-specific processing proteases;Metalloprotease DUBs;Deposition of new CENPA-containing nucleosomes at the centromere;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Estrogen-dependent gene expression;Meiotic recombination;Amyloid fiber formation 8339 HIST1H2BG False True Meiotic synapsis;Packaging Of Telomere Ends;Pre-NOTCH Transcription and Translation;Formation of the beta-catenin:TCF transactivating complex;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;HDACs deacetylate histones;HATs acetylate histones;HATs acetylate histones;SIRT1 negatively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;NoRC negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;B-WICH complex positively regulates rRNA expression;DNA methylation;Transcriptional regulation by small RNAs;Activation of anterior HOX genes in hindbrain development during early embryogenesis;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Ub-specific processing proteases;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Processing of DNA double-strand break ends;Deposition of new CENPA-containing nucleosomes at the centromere;G2/M DNA damage checkpoint;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;E3 ubiquitin ligases ubiquitinate target proteins;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Estrogen-dependent gene expression;Meiotic recombination;Amyloid fiber formation 8350 HIST1H3A False True Interleukin-7 signaling;Interleukin-7 signaling;Pre-NOTCH Transcription and Translation;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);HDACs deacetylate histones;PKMTs methylate histone lysines;HDMs demethylate histones;HATs acetylate histones;HATs acetylate histones;RMTs methylate histone arginines;Chromatin modifying enzymes;SIRT1 negatively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;NoRC negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;B-WICH complex positively regulates rRNA expression;DNA methylation;Transcriptional regulation by small RNAs;Activation of anterior HOX genes in hindbrain development during early embryogenesis;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Estrogen-dependent gene expression;Meiotic recombination;Amyloid fiber formation;Factors involved in megakaryocyte development and platelet production 8359 HIST1H4A False True Meiotic synapsis;Packaging Of Telomere Ends;Pre-NOTCH Transcription and Translation;Formation of the beta-catenin:TCF transactivating complex;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;HDACs deacetylate histones;PKMTs methylate histone lysines;HDMs demethylate histones;HATs acetylate histones;HATs acetylate histones;RMTs methylate histone arginines;SIRT1 negatively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;NoRC negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;SUMOylation of chromatin organization proteins;B-WICH complex positively regulates rRNA expression;DNA methylation;Transcriptional regulation by small RNAs;Activation of anterior HOX genes in hindbrain development during early embryogenesis;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Processing of DNA double-strand break ends;Deposition of new CENPA-containing nucleosomes at the centromere;G2/M DNA damage checkpoint;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Estrogen-dependent gene expression;Meiotic recombination;Amyloid fiber formation 8365 NA False True Meiotic synapsis;Packaging Of Telomere Ends;Pre-NOTCH Transcription and Translation;Formation of the beta-catenin:TCF transactivating complex;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;HDACs deacetylate histones;PKMTs methylate histone lysines;HDMs demethylate histones;HATs acetylate histones;HATs acetylate histones;RMTs methylate histone arginines;SIRT1 negatively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;NoRC negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;SUMOylation of chromatin organization proteins;B-WICH complex positively regulates rRNA expression;DNA methylation;Transcriptional regulation by small RNAs;Activation of anterior HOX genes in hindbrain development during early embryogenesis;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Processing of DNA double-strand break ends;Deposition of new CENPA-containing nucleosomes at the centromere;G2/M DNA damage checkpoint;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Estrogen-dependent gene expression;Meiotic recombination;Amyloid fiber formation 8369 HIST1H4G False True NA 8379 MAD1L1 False True Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase 8394 PIP5K1A False True Synthesis of PIPs at the plasma membrane;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 8407 TAGLN2 False True Platelet degranulation 8417 STX7 False True NA 8428 STK24 False True Apoptotic cleavage of cellular proteins;Apoptotic execution phase 8443 GNPAT False True Synthesis of PA;Plasmalogen biosynthesis;Peroxisomal protein import;Peroxisomal protein import 8445 DYRK2 False True Regulation of TP53 Activity through Phosphorylation 8450 CUL4B False True Recognition of DNA damage by PCNA-containing replication complex;DNA Damage Recognition in GG-NER;Formation of Incision Complex in GG-NER;Dual Incision in GG-NER;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Neddylation 8451 CUL4A False True Recognition of DNA damage by PCNA-containing replication complex;DNA Damage Recognition in GG-NER;Formation of Incision Complex in GG-NER;Dual Incision in GG-NER;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Neddylation 8452 CUL3 False True Degradation of DVL;Hedgehog 'on' state;Regulation of RAS by GAPs;Neddylation;Antigen processing: Ubiquitination & Proteasome degradation 8453 CUL2 False True Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Neddylation;Regulation of expression of SLITs and ROBOs;Antigen processing: Ubiquitination & Proteasome degradation 8454 CUL1 False True Activation of NF-kappaB in B cells;Prolactin receptor signaling;SCF-beta-TrCP mediated degradation of Emi1;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;NOTCH1 Intracellular Domain Regulates Transcription;Regulation of PLK1 Activity at G2/M Transition;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling;FCERI mediated NF-kB activation;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Circadian Clock;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;NIK-->noncanonical NF-kB signaling;MAP3K8 (TPL2)-dependent MAPK1/3 activation;Orc1 removal from chromatin;Cyclin D associated events in G1;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Neddylation;Interleukin-1 signaling;Iron uptake and transport;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation 8463 TEAD2 False True YAP1- and WWTR1 (TAZ)-stimulated gene expression;RUNX3 regulates YAP1-mediated transcription 8467 SMARCA5 False True NoRC negatively regulates rRNA expression;B-WICH complex positively regulates rRNA expression;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Deposition of new CENPA-containing nucleosomes at the centromere 8470 SORBS2 False True NA 8471 IRS4 False True IRS-related events triggered by IGF1R 8473 OGT False True HATs acetylate histones;UCH proteinases 8480 RAE1 False True ISG15 antiviral mechanism;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Rev-mediated nuclear export of HIV RNA;Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Viral Messenger RNA Synthesis;NEP/NS2 Interacts with the Cellular Export Machinery;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;snRNP Assembly;SUMOylation of DNA damage response and repair proteins;SUMOylation of ubiquitinylation proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;SUMOylation of SUMOylation proteins;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins;Transcriptional regulation by small RNAs;tRNA processing in the nucleus 8495 PPFIBP2 False True Receptor-type tyrosine-protein phosphatases 8496 PPFIBP1 False True Receptor-type tyrosine-protein phosphatases 8498 RANBP3 False True NA 8507 ENC1 False True NA 8508 NIPSNAP1 False True NA 8514 KCNAB2 False True Voltage gated Potassium channels;Neutrophil degranulation 8517 IKBKG False True Activation of NF-kappaB in B cells;Activation of NF-kappaB in B cells;ER-Phagosome pathway;NOD1/2 Signaling Pathway;TICAM1, RIP1-mediated IKK complex recruitment ;RIP-mediated NFkB activation via ZBP1;Downstream TCR signaling;FCERI mediated NF-kB activation;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;activated TAK1 mediates p38 MAPK activation;JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1;SUMOylation of immune response proteins;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;IKBKB deficiency causes SCID;IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR);IkBA variant leads to EDA-ID;CLEC7A (Dectin-1) signaling;MAP3K8 (TPL2)-dependent MAPK1/3 activation;Ub-specific processing proteases;Ovarian tumor domain proteases;Interleukin-1 signaling;TRAF6 mediated NF-kB activation;NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10;IRAK1 recruits IKK complex;IKK complex recruitment mediated by RIP1;IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 8520 HAT1 False True HATs acetylate histones 8534 CHST1 False True Keratan sulfate biosynthesis 8536 CAMK1 False True Negative regulation of NMDA receptor-mediated neuronal transmission;Activation of RAC1 downstream of NMDARs;Activation of RAC1 downstream of NMDARs 8539 API5 False True NA 8543 LMO4 False True NA 8544 PIR False True Digestion 8546 AP3B1 False True Golgi Associated Vesicle Biogenesis;Signaling by BRAF and RAF fusions 8550 MAPKAPK5 False True Oxidative Stress Induced Senescence;MAPK6/MAPK4 signaling;Regulation of TP53 Activity through Phosphorylation 8559 PRPF18 False True NA 8563 THOC5 False True Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA 3'-end processing 8565 YARS False True Cytosolic tRNA aminoacylation 8566 PDXK False True Neutrophil degranulation;Vitamins B6 activation to pyridoxal phosphate 8567 MADD False True Regulation of TNFR1 signaling;RAB GEFs exchange GTP for GDP on RABs 8569 MKNK1 False True Spry regulation of FGF signaling 8570 KHSRP False True ATF4 activates genes;KSRP (KHSRP) binds and destabilizes mRNA;KSRP (KHSRP) binds and destabilizes mRNA 8574 AKR7A2 False True Aflatoxin activation and detoxification 8607 RUVBL1 False True Telomere Extension By Telomerase;Formation of the beta-catenin:TCF transactivating complex;Formation of the beta-catenin:TCF transactivating complex;HATs acetylate histones;UCH proteinases;Ub-specific processing proteases;DNA Damage Recognition in GG-NER;Deposition of new CENPA-containing nucleosomes at the centromere 8624 PSMG1 False True NA 8626 TP63 False True Activation of PUMA and translocation to mitochondria;TP53 Regulates Metabolic Genes;TP53 Regulates Transcription of Genes Involved in Cytochrome C Release;TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain;TP53 Regulates Transcription of Caspase Activators and Caspases;TP53 Regulates Transcription of Death Receptors and Ligands;Regulation of TP53 Activity through Association with Co-factors 8639 AOC3 False True Phase I - Functionalization of compounds 8658 TNKS False True TCF dependent signaling in response to WNT;Degradation of AXIN;XAV939 inhibits tankyrase, stabilizing AXIN;Ub-specific processing proteases;Regulation of PTEN stability and activity 8659 ALDH4A1 False True Glyoxylate metabolism and glycine degradation;Proline catabolism 8660 IRS2 False True PI3K Cascade;IRS-mediated signalling;SOS-mediated signalling;SOS-mediated signalling;PIP3 activates AKT signaling;Interleukin-7 signaling;PI3K/AKT activation;PI3K/AKT activation;Constitutive Signaling by Aberrant PI3K in Cancer;IRS-related events triggered by IGF1R;Signaling by Leptin;RAF/MAP kinase cascade;PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling;IRS activation;Signal attenuation;RET signaling;Signaling by Erythropoietin;Erythropoietin activates Phosphoinositide-3-kinase (PI3K);Erythropoietin activates Phosphoinositide-3-kinase (PI3K);Erythropoietin activates Phospholipase C gamma (PLCG);Erythropoietin activates STAT5;Erythropoietin activates RAS;Erythropoietin activates RAS;Growth hormone receptor signaling 8661 EIF3A False True L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit 8662 EIF3B False True L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit 8663 EIF3C False True L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit 8664 EIF3D False True L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit 8666 EIF3G False True L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit 8667 EIF3H False True L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit 8668 EIF3I False True L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit 8672 EIF4G3 False True ISG15 antiviral mechanism 8673 VAMP8 False True ER-Phagosome pathway;Clathrin derived vesicle budding;Lysosome Vesicle Biogenesis;Golgi Associated Vesicle Biogenesis;Neutrophil degranulation;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis 8674 VAMP4 False True Retrograde transport at the Trans-Golgi-Network;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis 8678 BECN1 False True Macroautophagy;Ub-specific processing proteases 8683 SRSF9 False True Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing 8687 KRT38 False True Keratinization;Formation of the cornified envelope 8710 NA True False NA 8711 TNK1 False True NA 8724 SNX3 False True WNT ligand biogenesis and trafficking;Ub-specific processing proteases 8725 URI1 False True NA 8729 GBF1 False True Clathrin derived vesicle budding;VxPx cargo-targeting to cilium;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic 8733 GPAA1 False True Attachment of GPI anchor to uPAR 8737 RIPK1 False True Caspase activation via Death Receptors in the presence of ligand;TICAM1, RIP1-mediated IKK complex recruitment ;RIP-mediated NFkB activation via ZBP1;TRIF-mediated programmed cell death;TRP channels;Regulation by c-FLIP;RIPK1-mediated regulated necrosis;CASP8 activity is inhibited;TNFR1-induced proapoptotic signaling;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;Regulation of necroptotic cell death;Ub-specific processing proteases;Ovarian tumor domain proteases;Dimerization of procaspase-8;TNF signaling;TLR3-mediated TICAM1-dependent programmed cell death;NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10;IKK complex recruitment mediated by RIP1 8742 TNFSF12 False True TNFR2 non-canonical NF-kB pathway;TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 8760 CDS2 False True Synthesis of PG 8761 PABPC4 False True NA 8766 RAB11A False True Translocation of SLC2A4 (GLUT4) to the plasma membrane;Vasopressin regulates renal water homeostasis via Aquaporins;Anchoring of the basal body to the plasma membrane;VxPx cargo-targeting to cilium;TBC/RABGAPs;RAB geranylgeranylation 8775 NAPA False True COPII-mediated vesicle transport;Golgi Associated Vesicle Biogenesis;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;Intra-Golgi traffic;Retrograde transport at the Trans-Golgi-Network 8777 MPDZ False True NA 8786 RGS11 False True G alpha (i) signalling events;G alpha (i) signalling events;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 8794 TNFRSF10C False True TP53 Regulates Transcription of Death Receptors and Ligands 8798 DYRK4 False True NA 8799 PEX11B False True NA 8804 CREG1 False True Neutrophil degranulation 8805 TRIM24 False True Signaling by cytosolic FGFR1 fusion mutants;Signaling by FGFR1 in disease;Signaling by BRAF and RAF fusions 8815 BANF1 False True Integration of provirus;2-LTR circle formation;Integration of viral DNA into host genomic DNA;Autointegration results in viral DNA circles;APOBEC3G mediated resistance to HIV-1 infection;Vpr-mediated nuclear import of PICs;Clearance of Nuclear Envelope Membranes from Chromatin;Initiation of Nuclear Envelope Reformation 8826 IQGAP1 False True Nephrin family interactions;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;RHO GTPases activate IQGAPs;MAP2K and MAPK activation;Neutrophil degranulation;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF 8833 GMPS False True Purine ribonucleoside monophosphate biosynthesis 8834 TMEM11 False True Cristae formation 8836 GGH True True Neutrophil degranulation 8837 CFLAR False True Regulation by c-FLIP;RIPK1-mediated regulated necrosis;CASP8 activity is inhibited;Dimerization of procaspase-8;TRAIL signaling 8844 KSR1 False True RAF activation;MAP2K and MAPK activation;Negative regulation of MAPK pathway;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF 8848 TSC22D1 False True NA 8856 NR1I2 False True Nuclear Receptor transcription pathway;SUMOylation of intracellular receptors 8857 NA True False NA 8862 APLN False True Peptide ligand-binding receptors;G alpha (i) signalling events 8871 SYNJ2 False True Synthesis of PIPs at the plasma membrane;Clathrin-mediated endocytosis 8872 CDC123 False True NA 8874 ARHGEF7 False True EGFR downregulation;NRAGE signals death through JNK;Rho GTPase cycle;Ephrin signaling;G alpha (12/13) signalling events;Activation of RAC1 downstream of NMDARs 8878 SQSTM1 False True NRIF signals cell death from the nucleus;p75NTR recruits signalling complexes;NF-kB is activated and signals survival;Pink/Parkin Mediated Mitophagy;Interleukin-1 signaling 8880 FUBP1 False True NA 8882 ZPR1 False True NA 8886 DDX18 False True NA 8888 MCM3AP False True NA 8894 EIF2S2 False True L13a-mediated translational silencing of Ceruloplasmin expression;ABC-family proteins mediated transport;Translation initiation complex formation;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit;Recycling of eIF2:GDP 8899 PRPF4B False True NA 8907 AP1M1 False True Nef mediated downregulation of MHC class I complex cell surface expression;MHC class II antigen presentation;Lysosome Vesicle Biogenesis;Golgi Associated Vesicle Biogenesis;Neutrophil degranulation 8911 NA False True NCAM1 interactions 8914 TIMELESS False True Processing of DNA double-strand break ends 8925 HERC1 False True Antigen processing: Ubiquitination & Proteasome degradation 8943 AP3D1 False True NA 8945 BTRC False True Activation of NF-kappaB in B cells;Prolactin receptor signaling;SCF-beta-TrCP mediated degradation of Emi1;Vpu mediated degradation of CD4;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of PLK1 Activity at G2/M Transition;FCERI mediated NF-kB activation;Deactivation of the beta-catenin transactivating complex;Circadian Clock;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;NIK-->noncanonical NF-kB signaling;MAP3K8 (TPL2)-dependent MAPK1/3 activation;Neddylation;Interleukin-1 signaling;Antigen processing: Ubiquitination & Proteasome degradation 8971 H1FX False True NA 8976 WASL False True Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;NOSTRIN mediated eNOS trafficking;Nephrin family interactions;EPHB-mediated forward signaling;EPHB-mediated forward signaling;DCC mediated attractive signaling;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs;Clathrin-mediated endocytosis 8985 PLOD3 False True Collagen biosynthesis and modifying enzymes 9020 MAP3K14 False True CD28 dependent PI3K/Akt signaling;Dectin-1 mediated noncanonical NF-kB signaling;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 9022 CLIC3 False True NA 9025 RNF8 False True Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Processing of DNA double-strand break ends;G2/M DNA damage checkpoint 9026 HIP1R False True Golgi Associated Vesicle Biogenesis;Clathrin-mediated endocytosis 9027 NA False True Amyloid fiber formation 9031 BAZ1B False True B-WICH complex positively regulates rRNA expression;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 9039 UBA3 False True Dectin-1 mediated noncanonical NF-kB signaling;NIK-->noncanonical NF-kB signaling;Neddylation;Antigen processing: Ubiquitination & Proteasome degradation 9040 UBE2M False True TGF-beta receptor signaling activates SMADs;Dectin-1 mediated noncanonical NF-kB signaling;NIK-->noncanonical NF-kB signaling;Neddylation;Antigen processing: Ubiquitination & Proteasome degradation 9044 BTAF1 False True NA 9045 RPL14 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 9049 AIP False True Aryl hydrocarbon receptor signalling;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 9052 GPRC5A False True NA 9054 NFS1 False True Mitochondrial iron-sulfur cluster biogenesis;Molybdenum cofactor biosynthesis 9061 PAPSS1 False True Transport and synthesis of PAPS;Metabolism of ingested H2SeO4 and H2SeO3 into H2Se;Signaling by BRAF and RAF fusions 9063 PIAS2 False True SUMOylation of DNA damage response and repair proteins;SUMOylation of transcription factors;SUMOylation of ubiquitinylation proteins;SUMOylation of transcription cofactors;SUMOylation of intracellular receptors;SUMOylation of intracellular receptors;SUMOylation of chromatin organization proteins;Activation of anterior HOX genes in hindbrain development during early embryogenesis 9064 MAP3K6 False True NA 9071 CLDN10 False True Tight junction interactions 9092 SART1 False True mRNA Splicing - Major Pathway 9093 DNAJA3 False True NA 9094 UNC119 False True NA 9097 USP14 False True Ub-specific processing proteases 9099 USP2 False True TNFR1-induced proapoptotic signaling;Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;Ub-specific processing proteases;Regulation of TP53 Degradation 9101 USP8 False True Downregulation of ERBB2:ERBB3 signaling;Regulation of FZD by ubiquitination;Ub-specific processing proteases;Negative regulation of MET activity 9104 RGN False True NA 9111 NMI False True NA 9118 NA False True NA 9124 PDLIM1 False True NA 9131 AIFM1 False True NA 9132 KCNQ4 False True Voltage gated Potassium channels 9135 RABEP1 False True TBC/RABGAPs 9141 PDCD5 False True NA 9145 SYNGR1 False True Neutrophil degranulation 9146 HGS False True EGFR downregulation;Lysosome Vesicle Biogenesis;Ub-specific processing proteases;Negative regulation of MET activity;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;InlB-mediated entry of Listeria monocytogenes into host cell;Endosomal Sorting Complex Required For Transport (ESCRT) 9149 DYRK1B False True NA 9156 EXO1 False True Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha);Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta);HDR through Single Strand Annealing (SSA);HDR through Homologous Recombination (HRR);Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA);Resolution of D-loop Structures through Holliday Junction Intermediates;Homologous DNA Pairing and Strand Exchange;Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;Regulation of TP53 Activity through Phosphorylation;G2/M DNA damage checkpoint 9180 OSMR False True IL-6-type cytokine receptor ligand interactions 9181 ARHGEF2 False True NRAGE signals death through JNK;Rho GTPase cycle;G alpha (12/13) signalling events 9182 RASSF9 False True NA 9188 DDX21 False True B-WICH complex positively regulates rRNA expression;Major pathway of rRNA processing in the nucleolus and cytosol 9191 DEDD False True NA 9200 PTPLA False True Synthesis of very long-chain fatty acyl-CoAs 9203 ZMYM3 False True NA 9204 NA False True NA 9208 LRRFIP1 False True Signaling by cytosolic FGFR1 fusion mutants;LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production;Signaling by FGFR1 in disease 9209 LRRFIP2 False True NA 9212 AURKB False True Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;SUMOylation of DNA replication proteins;RHO GTPases Activate Formins;Regulation of TP53 Activity through Phosphorylation;Mitotic Prometaphase;Regulation of MECP2 expression and activity 9218 VAPA False True Sphingolipid de novo biosynthesis;Neutrophil degranulation 9221 NOLC1 False True NA 9223 MAGI1 False True NA 9230 RAB11B False True TBC/RABGAPs;RAB geranylgeranylation 9238 TBRG4 False True NA 9240 PNMA1 False True NA 9244 CRLF1 False True IL-6-type cytokine receptor ligand interactions;Interleukin-27 signaling 9252 RPS6KA5 False True ERK/MAPK targets;CREB phosphorylation;NCAM signaling for neurite out-growth;Recycling pathway of L1;CD209 (DC-SIGN) signaling 9261 MAPKAPK2 False True p38MAPK events;CREB phosphorylation;Synthesis of Leukotrienes (LT) and Eoxins (EX);Oxidative Stress Induced Senescence;Regulation of HSF1-mediated heat shock response;VEGFA-VEGFR2 Pathway;activated TAK1 mediates p38 MAPK activation;Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA;Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 9262 STK17B False True NA 9266 CYTH2 False True Intra-Golgi traffic 9271 PIWIL1 False True PIWI-interacting RNA (piRNA) biogenesis 9275 BCL7B False True NA 9296 ATP6V1F False True ROS, RNS production in phagocytes;Insulin receptor recycling;Transferrin endocytosis and recycling;Ion channel transport 9306 SOCS6 False True Regulation of KIT signaling;Neddylation 9320 TRIP12 False True Antigen processing: Ubiquitination & Proteasome degradation 9321 TRIP11 False True Intraflagellar transport;Intra-Golgi traffic 9330 GTF3C3 False True RNA Polymerase III Abortive And Retractive Initiation;RNA Polymerase III Transcription Initiation From Type 1 Promoter;RNA Polymerase III Transcription Initiation From Type 1 Promoter;RNA Polymerase III Transcription Initiation From Type 2 Promoter;RNA Polymerase III Transcription Initiation From Type 2 Promoter 9341 VAMP3 False True ER-Phagosome pathway;Retrograde transport at the Trans-Golgi-Network;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis 9343 EFTUD2 False True mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway 9349 RPL23 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 9352 TXNL1 False True NA 9361 LONP1 False True NA 9367 RAB9A False True Retrograde transport at the Trans-Golgi-Network;RAB geranylgeranylation;RAB GEFs exchange GTP for GDP on RABs 9373 PLAA False True NA 9380 GRHPR False True Glyoxylate metabolism and glycine degradation 9382 COG1 False True COPI-mediated anterograde transport;Intra-Golgi traffic;Retrograde transport at the Trans-Golgi-Network 9400 RECQL5 False True NA 9402 GRAP2 False True Signaling by SCF-KIT;Generation of second messenger molecules;DAP12 signaling;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;FCERI mediated Ca+2 mobilization;CD28 co-stimulation 9404 LPXN False True NA 9406 ZRANB2 False True NA 9410 SNRNP40 False True mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway 9413 FAM189A2 False True NA 9414 TJP2 False True Signaling by Hippo;Apoptotic cleavage of cell adhesion proteins 9416 DDX23 False True mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway 9445 ITM2B False True Amyloid fiber formation 9446 GSTO1 False True Methylation;Glutathione conjugation;Vitamin C (ascorbate) metabolism;Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 9448 MAP4K4 False True Oxidative Stress Induced Senescence 9451 EIF2AK3 False True PERK regulates gene expression 9467 SH3BP5 False True NA 9470 EIF4E2 False True ISG15 antiviral mechanism 9474 ATG5 False True Macroautophagy;Macroautophagy;Pink/Parkin Mediated Mitophagy;Receptor Mediated Mitophagy;Negative regulators of DDX58/IFIH1 signaling 9475 ROCK2 False True EPHB-mediated forward signaling;EPHB-mediated forward signaling;EPHA-mediated growth cone collapse;G alpha (12/13) signalling events;Sema4D induced cell migration and growth-cone collapse;Sema4D induced cell migration and growth-cone collapse;VEGFA-VEGFR2 Pathway;RHO GTPases Activate ROCKs;RHO GTPases Activate ROCKs 9482 STX8 False True NA 9491 PSMF1 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation 9493 KIF23 False True MHC class II antigen presentation;COPI-dependent Golgi-to-ER retrograde traffic;Mitotic Telophase/Cytokinesis;Kinesins 9512 PMPCB False True Mitochondrial protein import;Processing of SMDT1 9520 NPEPPS False True Antigen processing: Ubiquitination & Proteasome degradation 9522 SCAMP1 False True Neutrophil degranulation 9524 TECR False True Synthesis of very long-chain fatty acyl-CoAs 9529 BAG5 False True Regulation of HSF1-mediated heat shock response 9530 BAG4 False True Regulation of HSF1-mediated heat shock response;Signaling by FGFR1 in disease;TNF signaling;Signaling by plasma membrane FGFR1 fusions 9531 BAG3 False True Regulation of HSF1-mediated heat shock response 9532 BAG2 False True Regulation of HSF1-mediated heat shock response 9547 CXCL14 False True NA 9551 ATP5J2 False True Formation of ATP by chemiosmotic coupling;Cristae formation 9554 SEC22B False True ER-Phagosome pathway;COPII-mediated vesicle transport;Cargo concentration in the ER;COPI-dependent Golgi-to-ER retrograde traffic 9555 H2AFY False True NA 9557 CHD1L False True Formation of Incision Complex in GG-NER;Dual Incision in GG-NER 9564 BCAR1 False True Downstream signal transduction;p130Cas linkage to MAPK signaling for integrins;VEGFA-VEGFR2 Pathway;VEGFA-VEGFR2 Pathway;PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 9570 GOSR2 False True COPII-mediated vesicle transport;XBP1(S) activates chaperone genes;Cargo concentration in the ER;COPI-mediated anterograde transport;Intra-Golgi traffic 9584 RBM39 False True NA 9586 CREB5 False True NA 9587 MAD2L1BP False True NA 9588 PRDX6 False True Detoxification of Reactive Oxygen Species;Neutrophil degranulation 9601 PDIA4 False True NA 9612 NCOR2 False True PPARA activates gene expression;NOTCH1 Intracellular Domain Regulates Transcription;Downregulation of SMAD2/3:SMAD4 transcriptional activity;Downregulation of SMAD2/3:SMAD4 transcriptional activity;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;HDACs deacetylate histones;Transcriptional regulation of white adipocyte differentiation;Transcriptional regulation of white adipocyte differentiation;SUMOylation of transcription cofactors;Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha);Loss of MECP2 binding ability to the NCoR/SMRT complex;Regulation of MECP2 expression and activity 9628 RGS6 False True G alpha (i) signalling events;G alpha (i) signalling events;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 9631 NUP155 False True ISG15 antiviral mechanism;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Rev-mediated nuclear export of HIV RNA;Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Viral Messenger RNA Synthesis;NEP/NS2 Interacts with the Cellular Export Machinery;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;snRNP Assembly;SUMOylation of DNA damage response and repair proteins;SUMOylation of ubiquitinylation proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;SUMOylation of SUMOylation proteins;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins;Transcriptional regulation by small RNAs;tRNA processing in the nucleus 9632 SEC24C False True Regulation of cholesterol biosynthesis by SREBP (SREBF);COPII-mediated vesicle transport;MHC class II antigen presentation;Cargo concentration in the ER;Antigen Presentation: Folding, assembly and peptide loading of class I MHC 9635 CLCA2 False True Stimuli-sensing channels 9636 ISG15 False True ISG15 antiviral mechanism;NS1 Mediated Effects on Host Pathways;DDX58/IFIH1-mediated induction of interferon-alpha/beta;Termination of translesion DNA synthesis;Interferon alpha/beta signaling;Negative regulators of DDX58/IFIH1 signaling 9641 IKBKE False True SUMOylation of immune response proteins;TICAM1-dependent activation of IRF3/IRF7;TRAF3-dependent IRF activation pathway;TRAF6 mediated IRF7 activation;Negative regulators of DDX58/IFIH1 signaling;Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon 9647 PPM1F False True Negative regulation of NMDA receptor-mediated neuronal transmission 9650 NA False True NA 9656 MDC1 False True SUMOylation of DNA damage response and repair proteins;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Processing of DNA double-strand break ends;TP53 Regulates Transcription of DNA Repair Genes;G2/M DNA damage checkpoint 9669 EIF5B False True GTP hydrolysis and joining of the 60S ribosomal subunit 9673 SLC25A44 False True NA 9681 DEPDC5 False True NA 9685 CLINT1 False True Golgi Associated Vesicle Biogenesis 9688 NUP93 False True ISG15 antiviral mechanism;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Rev-mediated nuclear export of HIV RNA;Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Viral Messenger RNA Synthesis;NEP/NS2 Interacts with the Cellular Export Machinery;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;snRNP Assembly;SUMOylation of DNA damage response and repair proteins;SUMOylation of ubiquitinylation proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;SUMOylation of SUMOylation proteins;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins;Transcriptional regulation by small RNAs;tRNA processing in the nucleus 9689 BZW1 False True NA 9698 PUM1 False True Golgi Associated Vesicle Biogenesis 9702 CEP57 False True Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;AURKA Activation by TPX2 9711 KIAA0226 False True NA 9721 GPRIN2 False True NA 9729 KIAA0408 False True NA 9734 HDAC9 False True NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 9743 ARHGAP32 False True Rho GTPase cycle 9750 FAM65B False True NA 9753 ZSCAN12 False True NA 9757 KMT2B False True PKMTs methylate histone lysines;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 9759 HDAC4 False True NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;SUMOylation of intracellular receptors;SUMOylation of chromatin organization proteins;RUNX2 regulates chondrocyte maturation;RUNX3 regulates p14-ARF 9772 NA False True NA 9775 EIF4A3 False True Cleavage of Growing Transcript in the Termination Region ;ISG15 antiviral mechanism;Transport of Mature mRNA derived from an Intron-Containing Transcript;Deadenylation of mRNA;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 9777 TM9SF4 False True NA 9778 KIAA0232 False True NA 9782 MATR3 False True NA 9787 DLGAP5 False True NOTCH3 Intracellular Domain Regulates Transcription 9790 BMS1 False True rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol 9793 CKAP5 False True Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;RHO GTPases Activate Formins;Mitotic Prometaphase;AURKA Activation by TPX2 9798 IST1 False True Neutrophil degranulation 9810 RNF40 False True E3 ubiquitin ligases ubiquitinate target proteins 9815 GIT2 False True NA 9816 NA False True NA 9817 KEAP1 False True Ub-specific processing proteases;Neddylation;Antigen processing: Ubiquitination & Proteasome degradation 9824 NA False True Rho GTPase cycle 9828 NA False True NRAGE signals death through JNK;Rho GTPase cycle;G alpha (12/13) signalling events 9836 LCMT2 False True Synthesis of wybutosine at G37 of tRNA(Phe);Synthesis of wybutosine at G37 of tRNA(Phe) 9846 GAB2 False True PI3K Cascade;Signaling by SCF-KIT;Signaling by cytosolic FGFR1 fusion mutants;Role of LAT2/NTAL/LAB on calcium mobilization;Role of LAT2/NTAL/LAB on calcium mobilization;RET signaling;Interleukin-15 signaling;Interleukin receptor SHC signaling 9847 NA False True Translocation of SLC2A4 (GLUT4) to the plasma membrane 9849 ZNF518A False True NA 9859 CEP170 False True NA 9861 PSMD6 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation 9868 TOMM70A False True Mitochondrial protein import;Pink/Parkin Mediated Mitophagy;Ub-specific processing proteases 9869 SETDB1 False True PKMTs methylate histone lysines 9870 AREL1 False True Antigen processing: Ubiquitination & Proteasome degradation 9874 TLK1 False True NA 9877 NA False True Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA 3'-end processing 9878 TOX4 False True NA 9879 DDX46 False True mRNA Splicing - Major Pathway 9882 TBC1D4 False True Translocation of SLC2A4 (GLUT4) to the plasma membrane 9883 POM121 False True ISG15 antiviral mechanism;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Rev-mediated nuclear export of HIV RNA;Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Viral Messenger RNA Synthesis;NEP/NS2 Interacts with the Cellular Export Machinery;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;snRNP Assembly;SUMOylation of DNA damage response and repair proteins;SUMOylation of ubiquitinylation proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;SUMOylation of SUMOylation proteins;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins;Transcriptional regulation by small RNAs;tRNA processing in the nucleus 9886 RHOBTB1 False True Rho GTPase cycle 9889 ZBED4 False True NA 9894 TELO2 False True NA 9897 KIAA0196 False True NA 9908 G3BP2 False True NA 9918 NCAPD2 False True Condensation of Prometaphase Chromosomes;Condensation of Prometaphase Chromosomes 9919 SEC16A False True COPII-mediated vesicle transport 9921 RNF10 False True NA 9939 RBM8A False True Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 9948 WDR1 False True Platelet degranulation 9958 USP15 False True Downregulation of TGF-beta receptor signaling;UCH proteinases;Ub-specific processing proteases 9961 MVP False True Neutrophil degranulation 9967 THRAP3 False True PPARA activates gene expression;Transcriptional regulation of white adipocyte differentiation;Transcriptional regulation of white adipocyte differentiation 9970 NR1I3 False True Nuclear Receptor transcription pathway 9972 NUP153 False True ISG15 antiviral mechanism;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Rev-mediated nuclear export of HIV RNA;Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Viral Messenger RNA Synthesis;NEP/NS2 Interacts with the Cellular Export Machinery;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;snRNP Assembly;SUMOylation of DNA damage response and repair proteins;SUMOylation of ubiquitinylation proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;SUMOylation of SUMOylation proteins;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins;Transcriptional regulation by small RNAs;tRNA processing in the nucleus 9973 CCS False True Detoxification of Reactive Oxygen Species;Detoxification of Reactive Oxygen Species 9978 RBX1 False True Recognition of DNA damage by PCNA-containing replication complex;Prolactin receptor signaling;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Vif-mediated degradation of APOBEC3G;Degradation of beta-catenin by the destruction complex;NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Degradation of DVL;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;DNA Damage Recognition in GG-NER;Formation of Incision Complex in GG-NER;Dual Incision in GG-NER;Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;Orc1 removal from chromatin;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation 9987 HNRNPDL False True Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 9997 SCO2 False True TP53 Regulates Metabolic Genes;Respiratory electron transport 10009 ZBTB33 False True NA 10013 HDAC6 False True NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;HSF1 activation;Cilium Assembly;Transcriptional regulation by RUNX2;RUNX2 regulates osteoblast differentiation 10015 PDCD6IP False True Budding and maturation of HIV virion;Uptake and function of anthrax toxins 10016 PDCD6 False True NA 10026 PIGK False True Attachment of GPI anchor to uPAR 10036 CHAF1A False True NA 10040 TOM1L1 False True NA 10045 SH2D3A False True NA 10048 RANBP9 False True L1CAM interactions;RAF/MAP kinase cascade;MET activates RAS signaling 10049 DNAJB6 False True Regulation of HSF1-mediated heat shock response 10051 SMC4 False True Condensation of Prophase Chromosomes;Condensation of Prometaphase Chromosomes;Condensation of Prometaphase Chromosomes 10054 UBA2 False True SUMO is conjugated to E1 (UBA2:SAE1);SUMO is conjugated to E1 (UBA2:SAE1);SUMO is transferred from E1 to E2 (UBE2I, UBC9);SUMO is transferred from E1 to E2 (UBE2I, UBC9) 10055 SAE1 False True SUMO is conjugated to E1 (UBA2:SAE1);SUMO is conjugated to E1 (UBA2:SAE1);SUMO is transferred from E1 to E2 (UBE2I, UBC9);SUMO is transferred from E1 to E2 (UBE2I, UBC9) 10056 FARSB False True Cytosolic tRNA aminoacylation 10059 DNM1L False True Apoptotic execution phase 10060 NA False True ATP sensitive Potassium channels;ABC-family proteins mediated transport;Ion homeostasis;Defective ABCC9 causes dilated cardiomyopathy 10, familial atrial fibrillation 12 and hypertrichotic osteochondrodysplasia 10062 NR1H3 False True PPARA activates gene expression;Nuclear Receptor transcription pathway;SUMOylation of intracellular receptors;VLDLR internalisation and degradation 10063 COX17 False True Mitochondrial protein import 10075 HUWE1 False True Neutrophil degranulation;Antigen processing: Ubiquitination & Proteasome degradation 10092 ARPC5 False True Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;EPHB-mediated forward signaling;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs;Neutrophil degranulation;Clathrin-mediated endocytosis 10093 ARPC4 True True Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;EPHB-mediated forward signaling;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs;Clathrin-mediated endocytosis 10094 ARPC3 False True Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;EPHB-mediated forward signaling;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs;Clathrin-mediated endocytosis 10095 ARPC1B False True Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;EPHB-mediated forward signaling;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs 10096 ACTR3 False True Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;EPHB-mediated forward signaling;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs;Clathrin-mediated endocytosis 10097 ACTR2 True True Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;EPHB-mediated forward signaling;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs;Neutrophil degranulation;Clathrin-mediated endocytosis 10100 TSPAN2 False True NA 10105 PPIF False True NA 10107 TRIM10 False True Interferon gamma signaling 10109 ARPC2 False True Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;EPHB-mediated forward signaling;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs;Clathrin-mediated endocytosis 10110 SGK2 False True Stimuli-sensing channels 10113 PREB False True COPII-mediated vesicle transport;XBP1(S) activates chaperone genes;Cargo concentration in the ER 10128 LRPPRC False True TP53 Regulates Metabolic Genes;Respiratory electron transport 10130 PDIA6 False True XBP1(S) activates chaperone genes;Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Post-translational protein phosphorylation 10131 TRAP1 False True Respiratory electron transport 10133 OPTN False True Regulation of PLK1 Activity at G2/M Transition;TBC/RABGAPs 10134 BCAP31 False True Apoptotic cleavage of cellular proteins;Apoptotic execution phase;Antigen Presentation: Folding, assembly and peptide loading of class I MHC 10135 NAMPT False True BMAL1:CLOCK,NPAS2 activates circadian gene expression;Nicotinamide salvaging 10141 LINC01587 False True NA 10146 G3BP1 False True NA 10150 MBNL2 False True NA 10152 ABI2 False True Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;VEGFA-VEGFR2 Pathway;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs 10155 TRIM28 False True Generic Transcription Pathway;SUMOylation of transcription cofactors 10165 SLC25A13 False True Mitochondrial protein import;Gluconeogenesis 10168 ZNF197 False True Generic Transcription Pathway 10169 SERF2 False True NA 10174 SORBS3 False True Smooth Muscle Contraction 10180 RBM6 False True NA 10181 RBM5 False True mRNA Splicing - Major Pathway 10188 TNK2 False True NA 10189 ALYREF False True Cleavage of Growing Transcript in the Termination Region ;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing 10190 TXNDC9 False True NA 10195 ALG3 False True Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein;Defective ALG3 causes ALG3-CDG (CDG-1d) 10197 PSME3 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation 10198 NA False True NA 10200 MPHOSPH6 False True Major pathway of rRNA processing in the nucleolus and cytosol 10204 NUTF2 False True NA 10211 FLOT1 False True Synaptic adhesion-like molecules 10213 PSMD14 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;SCF(Skp2)-mediated degradation of p27/p21;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;Metalloprotease DUBs;Neutrophil degranulation;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of RUNX2 expression and activity;Regulation of RUNX3 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation 10226 PLIN3 False True Triglyceride catabolism;Retrograde transport at the Trans-Golgi-Network 10228 STX6 False True Intra-Golgi traffic;Retrograde transport at the Trans-Golgi-Network 10236 HNRNPR False True mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA 10238 DCAF7 False True Association of TriC/CCT with target proteins during biosynthesis;Neddylation 10250 SRRM1 False True Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing 10260 DENND4A False True RAB GEFs exchange GTP for GDP on RABs 10270 AKAP8 False True NA 10273 STUB1 False True Downregulation of TGF-beta receptor signaling;Downregulation of ERBB2 signaling;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity;Antigen processing: Ubiquitination & Proteasome degradation 10283 CWC27 False True mRNA Splicing - Major Pathway 10284 SAP18 False True HDACs deacetylate histones;NoRC negatively regulates rRNA expression 10286 BCAS2 False True mRNA Splicing - Major Pathway 10291 SF3A1 False True mRNA Splicing - Major Pathway 10294 DNAJA2 False True HSP90 chaperone cycle for steroid hormone receptors (SHR) 10298 PAK4 False True Activation of RAC1 10309 NA False True NA 10313 RTN3 False True Synaptic adhesion-like molecules 10319 LAMC3 False True Laminin interactions;Laminin interactions;Non-integrin membrane-ECM interactions;MET activates PTK2 signaling 10327 AKR1A1 False True Glutathione conjugation;Formation of xylulose-5-phosphate 10336 PCGF3 False True NA 10342 TFG False True COPII-mediated vesicle transport 10350 NA False True ABC transporters in lipid homeostasis 10362 HMG20B False True HDACs deacetylate histones;Factors involved in megakaryocyte development and platelet production 10367 MICU1 False True Mitochondrial calcium ion transport;Processing of SMDT1 10376 TUBA1B True True Translocation of SLC2A4 (GLUT4) to the plasma membrane;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;Gap junction assembly;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HSP90 chaperone cycle for steroid hormone receptors (SHR);Recruitment of NuMA to mitotic centrosomes;Formation of tubulin folding intermediates by CCT/TriC;Post-chaperonin tubulin folding pathway;Recycling pathway of L1;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;Carboxyterminal post-translational modifications of tubulin;Carboxyterminal post-translational modifications of tubulin;Activation of AMPK downstream of NMDARs;Kinesins 10381 TUBB3 False True Translocation of SLC2A4 (GLUT4) to the plasma membrane;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;Gap junction assembly;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HSP90 chaperone cycle for steroid hormone receptors (SHR);Recruitment of NuMA to mitotic centrosomes;Prefoldin mediated transfer of substrate to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Post-chaperonin tubulin folding pathway;Recycling pathway of L1;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;Carboxyterminal post-translational modifications of tubulin;Carboxyterminal post-translational modifications of tubulin;Activation of AMPK downstream of NMDARs;Kinesins 10383 TUBB4B True True Translocation of SLC2A4 (GLUT4) to the plasma membrane;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;Gap junction assembly;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;Regulation of PLK1 Activity at G2/M Transition;HSP90 chaperone cycle for steroid hormone receptors (SHR);Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Prefoldin mediated transfer of substrate to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Post-chaperonin tubulin folding pathway;Recycling pathway of L1;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Anchoring of the basal body to the plasma membrane;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;Neutrophil degranulation;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;AURKA Activation by TPX2;Carboxyterminal post-translational modifications of tubulin;Carboxyterminal post-translational modifications of tubulin;Activation of AMPK downstream of NMDARs;Kinesins 10385 BTN2A2 False True Butyrophilin (BTN) family interactions 10389 SCML2 False True NA 10391 CORO2B False True NA 10398 MYL9 False True EPHA-mediated growth cone collapse;Sema4D induced cell migration and growth-cone collapse;Smooth Muscle Contraction;RHO GTPases activate PKNs;RHO GTPases activate CIT;RHO GTPases Activate ROCKs;RHO GTPases activate PAKs;RHO GTPases activate PAKs;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 10399 GNB2L1 False True Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;TNFR1-mediated ceramide production 10403 NDC80 False True Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase 10406 WFDC2 False True NA 10409 BASP1 False True NA 10413 YAP1 False True Nuclear signaling by ERBB4;Signaling by Hippo;YAP1- and WWTR1 (TAZ)-stimulated gene expression;RUNX1 regulates transcription of genes involved in differentiation of HSCs;RUNX2 regulates osteoblast differentiation;RUNX3 regulates YAP1-mediated transcription 10419 PRMT5 False True snRNP Assembly;RMTs methylate histone arginines;Regulation of TP53 Activity through Methylation 10420 TESK2 False True NA 10421 CD2BP2 False True mRNA Splicing - Major Pathway 10424 NA False True NA 10432 RBM14 False True RUNX2 regulates bone development 10444 ZER1 False True NA 10447 FAM3C False True Platelet degranulation 10449 ACAA2 False True Mitochondrial Fatty Acid Beta-Oxidation 10452 TOMM40 False True Mitochondrial protein import;Pink/Parkin Mediated Mitophagy 10454 TAB1 False True NOD1/2 Signaling Pathway;FCERI mediated NF-kB activation;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;activated TAK1 mediates p38 MAPK activation;JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1;TNFR1-induced NFkappaB signaling pathway;CLEC7A (Dectin-1) signaling;Ub-specific processing proteases;TICAM1,TRAF6-dependent induction of TAK1 complex;Interleukin-1 signaling;IRAK2 mediated activation of TAK1 complex;TRAF6-mediated induction of TAK1 complex within TLR4 complex;IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 10458 BAIAP2 False True Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;VEGFA-VEGFR2 Pathway;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs 10460 TACC3 False True NOTCH3 Activation and Transmission of Signal to the Nucleus;Negative regulation of NOTCH4 signaling 10461 MERTK False True Cell surface interactions at the vascular wall 10468 FST False True Antagonism of Activin by Follistatin 10469 TIMM44 False True Mitochondrial protein import 10475 TRIM38 False True Interferon gamma signaling 10476 ATP5H False True Formation of ATP by chemiosmotic coupling;Cristae formation 10480 EIF3M False True L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit 10486 CAP2 False True Role of ABL in ROBO-SLIT signaling 10488 CREB3 False True CREB3 factors activate genes;CREB3 factors activate genes 10490 VTI1B False True Platelet degranulation 10491 CRTAP False True Collagen biosynthesis and modifying enzymes 10492 SYNCRIP False True NA 10493 VAT1 False True Neutrophil degranulation 10498 CARM1 False True RORA activates gene expression;BMAL1:CLOCK,NPAS2 activates circadian gene expression;PPARA activates gene expression;PPARA activates gene expression;Transcriptional activation of mitochondrial biogenesis;Activation of gene expression by SREBF (SREBP);RMTs methylate histone arginines;Transcriptional regulation of white adipocyte differentiation;Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha);Circadian Clock;TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest;Estrogen-dependent gene expression 10513 APPBP2 False True NA 10514 MYBBP1A False True B-WICH complex positively regulates rRNA expression 10521 DDX17 False True SUMOylation of transcription cofactors 10523 CHERP False True mRNA Splicing - Major Pathway 10524 KAT5 False True Formation of the beta-catenin:TCF transactivating complex;Formation of the beta-catenin:TCF transactivating complex;DNA Damage/Telomere Stress Induced Senescence;HATs acetylate histones;HDR through Single Strand Annealing (SSA);HDR through Homologous Recombination (HRR);Sensing of DNA Double Strand Breaks;Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA);Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Resolution of D-loop Structures through Holliday Junction Intermediates;Nonhomologous End-Joining (NHEJ);Homologous DNA Pairing and Strand Exchange;Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;Regulation of TP53 Activity through Phosphorylation;G2/M DNA damage checkpoint;Estrogen-dependent gene expression 10525 HYOU1 False True Scavenging by Class F Receptors;Scavenging by Class F Receptors;XBP1(S) activates chaperone genes 10526 IPO8 False True Transcriptional regulation by small RNAs 10527 IPO7 False True NA 10528 NOP56 False True Association of TriC/CCT with target proteins during biosynthesis;rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol 10531 PITRM1 False True Mitochondrial protein import 10540 DCTN2 False True MHC class II antigen presentation;Regulation of PLK1 Activity at G2/M Transition;HSP90 chaperone cycle for steroid hormone receptors (SHR);Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;COPI-mediated anterograde transport;COPI-independent Golgi-to-ER retrograde traffic;AURKA Activation by TPX2 10542 LAMTOR5 False True Macroautophagy;mTOR signalling;mTORC1-mediated signalling;Energy dependent regulation of mTOR by LKB1-AMPK;TP53 Regulates Metabolic Genes;Regulation of PTEN gene transcription 10544 PROCR False True Common Pathway of Fibrin Clot Formation;Cell surface interactions at the vascular wall 10549 PRDX4 False True Neutrophil degranulation 10552 ARPC1A False True Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;EPHB-mediated forward signaling;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs;Clathrin-mediated endocytosis 10559 SLC35A1 False True Sialic acid metabolism;Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F);Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F);Transport of nucleotide sugars 10567 RABAC1 False True NA 10569 SLU7 False True Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing 10570 DPYSL4 False True CRMPs in Sema3A signaling 10573 MRPL28 False True Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation elongation;Mitochondrial translation termination 10574 CCT7 False True Prefoldin mediated transfer of substrate to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Folding of actin by CCT/TriC;Association of TriC/CCT with target proteins during biosynthesis;Association of TriC/CCT with target proteins during biosynthesis;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 10575 CCT4 False True Prefoldin mediated transfer of substrate to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Folding of actin by CCT/TriC;Association of TriC/CCT with target proteins during biosynthesis;Association of TriC/CCT with target proteins during biosynthesis;BBSome-mediated cargo-targeting to cilium;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 10576 CCT2 False True Prefoldin mediated transfer of substrate to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Folding of actin by CCT/TriC;Association of TriC/CCT with target proteins during biosynthesis;Association of TriC/CCT with target proteins during biosynthesis;BBSome-mediated cargo-targeting to cilium;Neutrophil degranulation;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 10577 NPC2 True True Neutrophil degranulation;LDL clearance 10580 SORBS1 False True Smooth Muscle Contraction 10584 COLEC10 False True Lectin pathway of complement activation;Initial triggering of complement 10591 DNPH1 False True Purine catabolism 10594 PRPF8 False True mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway 10598 AHSA1 False True NA 10607 TBL3 False True rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol 10611 PDLIM5 False True Neurexins and neuroligins 10616 RBCK1 False True Regulation of TNFR1 signaling;TNFR1-induced NFkappaB signaling pathway;Antigen processing: Ubiquitination & Proteasome degradation 10618 TGOLN2 False True Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Golgi Associated Vesicle Biogenesis;Retrograde transport at the Trans-Golgi-Network;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Post-translational protein phosphorylation 10625 IVNS1ABP False True NA 10627 MYL12A False True EPHA-mediated growth cone collapse;Ephrin signaling;Sema4D induced cell migration and growth-cone collapse;Smooth Muscle Contraction;RHO GTPases activate PKNs;RHO GTPases activate CIT;RHO GTPases Activate ROCKs;RHO GTPases activate PAKs;RHO GTPases activate PAKs 10628 TXNIP False True The NLRP3 inflammasome;The NLRP3 inflammasome;Regulation of FOXO transcriptional activity by acetylation 10641 NPRL2 False True NA 10645 CAMKK2 False True CaMK IV-mediated phosphorylation of CREB;CaMK IV-mediated phosphorylation of CREB;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;Activation of RAC1 downstream of NMDARs;Activation of RAC1 downstream of NMDARs;Activation of AMPK downstream of NMDARs 10650 NA False True TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 10652 YKT6 False True COPII-mediated vesicle transport;COPI-mediated anterograde transport;Intra-Golgi traffic 10656 KHDRBS3 False True PTK6 Regulates Proteins Involved in RNA Processing 10667 FARS2 False True Mitochondrial tRNA aminoacylation 10671 DCTN6 False True MHC class II antigen presentation;HSP90 chaperone cycle for steroid hormone receptors (SHR);COPI-mediated anterograde transport;COPI-independent Golgi-to-ER retrograde traffic 10682 EBP False True Cholesterol biosynthesis via desmosterol;Cholesterol biosynthesis via lathosterol 10687 PNMA2 False True NA 10693 CCT6B False True Prefoldin mediated transfer of substrate to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Folding of actin by CCT/TriC;Association of TriC/CCT with target proteins during biosynthesis;Association of TriC/CCT with target proteins during biosynthesis;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 10694 CCT8 False True Prefoldin mediated transfer of substrate to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Folding of actin by CCT/TriC;Association of TriC/CCT with target proteins during biosynthesis;Association of TriC/CCT with target proteins during biosynthesis;BBSome-mediated cargo-targeting to cilium;Neutrophil degranulation;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 10726 NUDC False True Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase;Mitotic Telophase/Cytokinesis 10728 PTGES3 False True Synthesis of Prostaglandins (PG) and Thromboxanes (TX);HSP90 chaperone cycle for steroid hormone receptors (SHR);HSF1 activation;Attenuation phase;Aryl hydrocarbon receptor signalling;ESR-mediated signaling;Estrogen-dependent gene expression 10733 PLK4 False True Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;AURKA Activation by TPX2 10745 PHTF1 False True NA 10746 MAP3K2 False True NA 10749 KIF1C False True COPI-dependent Golgi-to-ER retrograde traffic;Kinesins 10762 NUP50 False True ISG15 antiviral mechanism;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Rev-mediated nuclear export of HIV RNA;Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Viral Messenger RNA Synthesis;NEP/NS2 Interacts with the Cellular Export Machinery;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;snRNP Assembly;SUMOylation of DNA damage response and repair proteins;SUMOylation of ubiquitinylation proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;SUMOylation of SUMOylation proteins;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins;Transcriptional regulation by small RNAs;tRNA processing in the nucleus 10763 NES False True NA 10768 AHCYL1 False True PLC beta mediated events;DAG and IP3 signaling;Role of phospholipids in phagocytosis;FCERI mediated Ca+2 mobilization;Regulation of insulin secretion;VEGFR2 mediated cell proliferation;Ion homeostasis;Ion homeostasis;CLEC7A (Dectin-1) induces NFAT activation;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 10772 SRSF10 False True mRNA Splicing - Major Pathway 10783 NEK6 False True Activation of NIMA Kinases NEK9, NEK6, NEK7;Nuclear Pore Complex (NPC) Disassembly 10785 WDR4 False True tRNA modification in the nucleus and cytosol 10787 NCKAP1 False True Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;VEGFA-VEGFR2 Pathway;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs 10791 NA False True NA 10797 MTHFD2 False True Metabolism of folate and pterines 10801 SEPT9 False True NA 10802 SEC24A False True Regulation of cholesterol biosynthesis by SREBP (SREBF);COPII-mediated vesicle transport;MHC class II antigen presentation;Cargo concentration in the ER;Antigen Presentation: Folding, assembly and peptide loading of class I MHC 10808 HSPH1 False True Scavenging by Class F Receptors;Scavenging by Class F Receptors;Regulation of HSF1-mediated heat shock response 10826 NA False True NA 10845 CLPX False True NA 10856 RUVBL2 False True Telomere Extension By Telomerase;HATs acetylate histones 10868 USP20 False True Ub-specific processing proteases 10869 USP19 False True Ub-specific processing proteases 10890 RAB10 False True Translocation of SLC2A4 (GLUT4) to the plasma membrane;Neutrophil degranulation;RAB geranylgeranylation;RAB GEFs exchange GTP for GDP on RABs 10906 TRAFD1 False True NA 10907 TXNL4A False True mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway 10910 SUGT1 False True The NLRP3 inflammasome 10912 GADD45G False True NA 10914 PAPOLA False True Cleavage of Growing Transcript in the Termination Region ;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Processing of Intronless Pre-mRNAs 10916 MAGED2 False True Platelet degranulation 10921 RNPS1 False True Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 10922 FASTK False True NA 10923 SUB1 False True NA 10927 SPIN1 False True NA 10928 RALBP1 False True Rho GTPase cycle 10929 SRSF8 False True NA 10933 MORF4L1 False True HATs acetylate histones 10935 PRDX3 False True Detoxification of Reactive Oxygen Species 10938 EHD1 False True Factors involved in megakaryocyte development and platelet production 10946 SF3A3 False True mRNA Splicing - Major Pathway 10948 STARD3 False True Pregnenolone biosynthesis 10949 HNRNPA0 False True mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA 10951 CBX1 False True NA 10953 TOMM34 False True NA 10956 OS9 False True ABC-family proteins mediated transport;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Defective CFTR causes cystic fibrosis;ER Quality Control Compartment (ERQC) 10963 STIP1 False True HSP90 chaperone cycle for steroid hormone receptors (SHR) 10970 CKAP4 False True Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Surfactant metabolism;Neutrophil degranulation;Post-translational protein phosphorylation 10971 YWHAQ False True Activation of BAD and translocation to mitochondria ;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Translocation of SLC2A4 (GLUT4) to the plasma membrane;RHO GTPases activate PKNs;TP53 Regulates Metabolic Genes;Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;Regulation of localization of FOXO transcription factors 10973 ASCC3 False True ALKBH3 mediated reversal of alkylation damage 10979 FERMT2 False True Cell-extracellular matrix interactions 10980 COPS6 False True DNA Damage Recognition in GG-NER;Formation of TC-NER Pre-Incision Complex;Cargo recognition for clathrin-mediated endocytosis;Neddylation 10982 MAPRE2 False True NA 10985 GCN1L1 False True NA 10987 COPS5 False True DNA Damage Recognition in GG-NER;Formation of TC-NER Pre-Incision Complex;Cargo recognition for clathrin-mediated endocytosis;Neddylation 10988 METAP2 False True Inactivation, recovery and regulation of the phototransduction cascade 10989 IMMT False True Cristae formation 10992 SF3B2 False True mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway 11007 CCDC85B False True NA 11009 IL24 False True Interleukin-20 family signaling 11010 GLIPR1 False True PPARA activates gene expression;Neutrophil degranulation 11030 RBPMS False True NA 11034 DSTN False True NA 11040 PIM2 False True NA 11047 ADRM1 False True UCH proteinases;Ub-specific processing proteases 11052 CPSF6 False True Signaling by cytosolic FGFR1 fusion mutants;Signaling by FGFR1 in disease 11059 WWP1 False True Downregulation of ERBB4 signaling;Stimuli-sensing channels;Regulation of RUNX2 expression and activity;Antigen processing: Ubiquitination & Proteasome degradation 11067 C10orf10 False True NA 11068 CYB561D2 False True NA 11078 TRIOBP False True NA 11079 RER1 False True NA 11080 DNAJB4 False True NA 11091 WDR5 False True PKMTs methylate histone lysines;HATs acetylate histones;HATs acetylate histones;RMTs methylate histone arginines;Activation of anterior HOX genes in hindbrain development during early embryogenesis;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;Neddylation 11100 HNRNPUL1 False True mRNA Splicing - Major Pathway 11103 KRR1 False True rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol 11124 FAF1 False True NA 11133 KPTN False True NA 11136 SLC7A9 False True Basigin interactions;Amino acid transport across the plasma membrane;Defective SLC7A9 causes cystinuria (CSNU) 11140 CDC37 False True Signaling by ERBB2;Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants;Constitutive Signaling by EGFRvIII;Downregulation of ERBB2 signaling 11144 DMC1 False True Meiotic recombination 11146 GLMN False True Antigen processing: Ubiquitination & Proteasome degradation 11149 BVES False True NA 11155 LDB3 False True NA 11160 ERLIN2 False True ABC-family proteins mediated transport;Signaling by FGFR1 in disease;Defective CFTR causes cystic fibrosis;Signaling by plasma membrane FGFR1 fusions 11161 NA False True NA 11170 FAM107A False True NA 11184 MAP4K1 False True NA 11187 PKP3 False True Keratinization;Formation of the cornified envelope 11190 CEP250 False True Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;AURKA Activation by TPX2 11198 SUPT16H False True Formation of RNA Pol II elongation complex ;Formation of HIV elongation complex in the absence of HIV Tat;Formation of HIV-1 elongation complex containing HIV-1 Tat;Pausing and recovery of Tat-mediated HIV elongation;Tat-mediated HIV elongation arrest and recovery;Tat-mediated elongation of the HIV-1 transcript;HIV elongation arrest and recovery;Pausing and recovery of HIV elongation;RNA Polymerase II Pre-transcription Events;TP53 Regulates Transcription of DNA Repair Genes;Regulation of TP53 Activity through Phosphorylation;RNA Polymerase II Transcription Elongation 11212 PROSC False True NA 11213 IRAK3 False True MyD88:MAL(TIRAP) cascade initiated on plasma membrane;Interleukin-1 signaling 11217 AKAP2 False True NA 11222 MRPL3 False True Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation elongation;Mitochondrial translation termination 11224 RPL35 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 11226 GALNT6 False True O-linked glycosylation of mucins 11228 RASSF8 False True NA 11235 PDCD10 False True NA 11243 PMF1 False True Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase 11244 ZHX1 False True NA 11267 SNF8 False True Endosomal Sorting Complex Required For Transport (ESCRT) 11269 DDX19B False True NA 11284 PNKP False True APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway 11285 B4GALT7 False True A tetrasaccharide linker sequence is required for GAG synthesis;Defective B4GALT7 causes EDS, progeroid type 11313 LYPLA2 False True L1CAM interactions 11315 PARK7 False True SUMOylation of transcription cofactors 11325 DDX42 False True mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway 11329 STK38 False True NA 11331 PHB2 False True Processing of SMDT1 11332 ACOT7 False True Mitochondrial Fatty Acid Beta-Oxidation 11333 PDAP1 False True Neutrophil degranulation 11335 CBX3 False True ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;RNA Polymerase I Chain Elongation;Transcriptional Regulation by E2F6 11338 U2AF2 False True Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing 11339 OIP5 False True Deposition of new CENPA-containing nucleosomes at the centromere 11343 MGLL False True Acyl chain remodeling of DAG and TAG;Triglyceride catabolism;Arachidonate production from DAG 11344 TWF2 False True NA 11346 SYNPO False True NA 11622 NA False True NA 12460 NA False True NA 12550 Cdh1 False True NA 13505 NA False True NA 13510 NA False True NA 14828 Hspa5 False True NA 15481 NA False True NA 15502 NA False True NA 15505 Hsph1 False True NA 15511 NA False True NA 15512 NA False True NA 15525 NA False True NA 17248 Mdm4 False True NA 17279 Melk False True NA 18415 NA False True NA 19015 Ppard False True NA 19016 Pparg False True NA 20655 Sod1 False True NA 22802 NA False True Stimuli-sensing channels 22803 XRN2 False True Association of TriC/CCT with target proteins during biosynthesis;Major pathway of rRNA processing in the nucleolus and cytosol 22818 COPZ1 False True COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic 22820 COPG1 False True COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic 22822 PHLDA1 False True Interaction between PHLDA1 and AURKA 22824 HSPA4L False True Regulation of HSF1-mediated heat shock response 22826 DNAJC8 False True mRNA Splicing - Major Pathway 22827 PUF60 False True mRNA Splicing - Major Pathway 22828 NA False True NA 22832 CEP162 False True Anchoring of the basal body to the plasma membrane 22837 COBLL1 False True NA 22841 RAB11FIP2 False True Vasopressin regulates renal water homeostasis via Aquaporins 22848 AAK1 False True Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis 22858 ICK False True NA 22859 NA False True NA 22868 FASTKD2 False True NA 22872 SEC31A False True COPII-mediated vesicle transport;MHC class II antigen presentation;XBP1(S) activates chaperone genes;Antigen Presentation: Folding, assembly and peptide loading of class I MHC 22882 ZHX2 False True NA 22907 DHX30 False True NA 22908 SACM1L False True Synthesis of PIPs at the ER membrane;Synthesis of PIPs at the Golgi membrane 22913 RALY False True NA 22919 MAPRE1 False True Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;RHO GTPases Activate Formins;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;AURKA Activation by TPX2 22931 RAB18 False True Neutrophil degranulation;COPI-independent Golgi-to-ER retrograde traffic;RAB geranylgeranylation;RAB GEFs exchange GTP for GDP on RABs 22938 SNW1 False True Pre-NOTCH Transcription and Translation;Pre-NOTCH Transcription and Translation;Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells;NOTCH1 Intracellular Domain Regulates Transcription;NOTCH1 Intracellular Domain Regulates Transcription;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Notch-HLH transcription pathway;mRNA Splicing - Major Pathway;RUNX3 regulates NOTCH signaling;RUNX3 regulates NOTCH signaling;NOTCH3 Intracellular Domain Regulates Transcription;NOTCH3 Intracellular Domain Regulates Transcription;NOTCH4 Intracellular Domain Regulates Transcription 22948 CCT5 False True Prefoldin mediated transfer of substrate to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Folding of actin by CCT/TriC;Association of TriC/CCT with target proteins during biosynthesis;Association of TriC/CCT with target proteins during biosynthesis;BBSome-mediated cargo-targeting to cilium;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 22954 TRIM32 False True Regulation of innate immune responses to cytosolic DNA;Antigen processing: Ubiquitination & Proteasome degradation 22974 TPX2 False True Regulation of TP53 Activity through Phosphorylation;AURKA Activation by TPX2 22980 TCF25 False True NA 22981 NINL False True Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;AURKA Activation by TPX2 22985 ACIN1 False True Apoptotic cleavage of cellular proteins 22992 KDM2A False True HDMs demethylate histones 22994 CEP131 False True Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;AURKA Activation by TPX2 22995 CEP152 False True Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;AURKA Activation by TPX2 22998 LIMCH1 False True NA 23011 RAB21 False True RAB geranylgeranylation;RAB GEFs exchange GTP for GDP on RABs 23012 STK38L False True NA 23015 NA False True NA 23019 CNOT1 False True Deadenylation of mRNA;TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 23020 SNRNP200 False True mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway 23022 PALLD False True NA 23028 KDM1A False True HDACs deacetylate histones;HDMs demethylate histones;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Regulation of PTEN gene transcription;Estrogen-dependent gene expression;Factors involved in megakaryocyte development and platelet production 23031 MAST3 False True NA 23036 NA False True NA 23039 XPO7 False True NA 23042 PDXDC1 False True NA 23047 PDS5B False True Separation of Sister Chromatids;Establishment of Sister Chromatid Cohesion;Cohesin Loading onto Chromatin;Resolution of Sister Chromatid Cohesion 23052 ENDOD1 False True Platelet degranulation 23064 SETX False True NA 23072 HECW1 False True Degradation of DVL 23074 NA False True NA 23076 RRP1B False True NA 23077 MYCBP2 False True NA 23087 TRIM35 False True Interferon gamma signaling 23090 ZNF423 False True NA 23094 NA False True NA 23095 KIF1B False True COPI-dependent Golgi-to-ER retrograde traffic;Kinesins 23098 SARM1 False True MyD88-independent TLR4 cascade ;Toll Like Receptor 3 (TLR3) Cascade;Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon;IKK complex recruitment mediated by RIP1;TRAF6-mediated induction of TAK1 complex within TLR4 complex 23099 ZBTB43 False True NA 23108 NA False True Rap1 signalling 23118 TAB2 False True Nuclear signaling by ERBB4;Nuclear signaling by ERBB4;NOD1/2 Signaling Pathway;Downstream TCR signaling;FCERI mediated NF-kB activation;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;activated TAK1 mediates p38 MAPK activation;JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1;TNFR1-induced NFkappaB signaling pathway;CLEC7A (Dectin-1) signaling;TICAM1,TRAF6-dependent induction of TAK1 complex;Interleukin-1 signaling;IRAK2 mediated activation of TAK1 complex;TRAF6-mediated induction of TAK1 complex within TLR4 complex;IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 23122 CLASP2 False True Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;Role of ABL in ROBO-SLIT signaling;RHO GTPases Activate Formins;Mitotic Prometaphase 23126 POGZ False True NA 23132 RAD54L2 False True NA 23136 EPB41L3 False True Neurexins and neuroligins 23139 MAST2 False True NA 23157 SEPT6 False True NA 23164 MPRIP False True Signaling by BRAF and RAF fusions 23165 NUP205 False True ISG15 antiviral mechanism;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Rev-mediated nuclear export of HIV RNA;Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Viral Messenger RNA Synthesis;NEP/NS2 Interacts with the Cellular Export Machinery;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;snRNP Assembly;SUMOylation of DNA damage response and repair proteins;SUMOylation of ubiquitinylation proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;SUMOylation of SUMOylation proteins;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins;Transcriptional regulation by small RNAs;tRNA processing in the nucleus 23171 GPD1L False True Synthesis of PA 23178 PASK False True NA 23185 NA False True NA 23189 NA False True Estrogen-dependent gene expression 23191 CYFIP1 False True Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;VEGFA-VEGFR2 Pathway;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs;Neutrophil degranulation 23193 GANAB False True N-glycan trimming in the ER and Calnexin/Calreticulin cycle;Calnexin/calreticulin cycle 23197 FAF2 False True Neutrophil degranulation 23198 PSME4 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Antigen processing: Ubiquitination & Proteasome degradation 23203 PMPCA False True Mitochondrial protein import;Processing of SMDT1 23204 ARL6IP1 False True NA 23211 NA False True NA 23214 XPO6 False True NA 23216 TBC1D1 False True Translocation of SLC2A4 (GLUT4) to the plasma membrane;Translocation of SLC2A4 (GLUT4) to the plasma membrane 23218 NA False True Neutrophil degranulation 23219 FBXO28 False True NA 23220 DTX4 False True IRF3 mediated activation of type 1 IFN;Activated NOTCH1 Transmits Signal to the Nucleus;Activated NOTCH1 Transmits Signal to the Nucleus;Regulation of innate immune responses to cytosolic DNA;IRF3-mediated induction of type I IFN 23221 RHOBTB2 False True Rho GTPase cycle 23224 SYNE2 False True Meiotic synapsis 23225 NUP210 False True ISG15 antiviral mechanism;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Rev-mediated nuclear export of HIV RNA;Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Viral Messenger RNA Synthesis;NEP/NS2 Interacts with the Cellular Export Machinery;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;snRNP Assembly;SUMOylation of DNA damage response and repair proteins;SUMOylation of ubiquitinylation proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;SUMOylation of SUMOylation proteins;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins;Transcriptional regulation by small RNAs;tRNA processing in the nucleus 23234 DNAJC9 False True NA 23237 ARC False True NA 23242 COBL False True NA 23244 PDS5A False True Separation of Sister Chromatids;Establishment of Sister Chromatid Cohesion;Cohesin Loading onto Chromatin;Resolution of Sister Chromatid Cohesion 23248 NA False True RNA polymerase II transcribes snRNA genes;RNA polymerase II transcribes snRNA genes 23255 MTCL1 False True NA 23261 NA False True NA 23262 PPIP5K2 False True Synthesis of pyrophosphates in the cytosol 23264 ZC3H7B False True NA 23276 KLHL18 False True NA 23281 MTUS2 False True NA 23288 IQCE False True Activation of SMO 23291 FBXW11 False True Activation of NF-kappaB in B cells;Downstream TCR signaling;Regulation of PLK1 Activity at G2/M Transition;FCERI mediated NF-kB activation;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;NIK-->noncanonical NF-kB signaling;MAP3K8 (TPL2)-dependent MAPK1/3 activation;Neddylation;Antigen processing: Ubiquitination & Proteasome degradation 23294 ANKS1A False True NA 23303 KIF13B False True COPI-dependent Golgi-to-ER retrograde traffic;Kinesins 23306 TMEM194A False True NA 23310 NCAPD3 False True Condensation of Prophase Chromosomes 23313 KIAA0930 False True NA 23315 NA False True Sodium/Proton exchangers 23317 DNAJC13 False True Neutrophil degranulation 23321 TRIM2 False True Interferon gamma signaling 23326 USP22 False True HATs acetylate histones;Ub-specific processing proteases 23327 NEDD4L False True Budding and maturation of HIV virion;Downregulation of TGF-beta receptor signaling;Downregulation of SMAD2/3:SMAD4 transcriptional activity;Stimuli-sensing channels;Antigen processing: Ubiquitination & Proteasome degradation 23328 SASH1 False True NA 23332 CLASP1 False True Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Role of ABL in ROBO-SLIT signaling;Anchoring of the basal body to the plasma membrane;RHO GTPases Activate Formins;Mitotic Prometaphase;AURKA Activation by TPX2 23333 NA False True NA 23334 SZT2 False True NA 23345 SYNE1 False True Meiotic synapsis 23350 U2SURP False True mRNA Splicing - Major Pathway 23358 USP24 False True Ub-specific processing proteases 23361 NA False True NA 23363 OBSL1 False True Neddylation 23367 LARP1 False True NA 23373 CRTC1 False True Transcriptional activation of mitochondrial biogenesis;Circadian Clock;Circadian Clock 23380 SRGAP2 False True Rho GTPase cycle;Inactivation of CDC42 and RAC1;RHO GTPases Activate Formins 23384 NA False True NA 23385 NCSTN False True Nuclear signaling by ERBB4;Degradation of the extracellular matrix;Regulated proteolysis of p75NTR;NRIF signals cell death from the nucleus;Activated NOTCH1 Transmits Signal to the Nucleus;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;NOTCH2 Activation and Transmission of Signal to the Nucleus;EPH-ephrin mediated repulsion of cells;Neutrophil degranulation;NOTCH3 Activation and Transmission of Signal to the Nucleus;NOTCH4 Activation and Transmission of Signal to the Nucleus;Noncanonical activation of NOTCH3;Amyloid fiber formation 23386 NUDCD3 False True NA 23387 SIK3 False True NA 23392 KIAA0368 False True NA 23397 NCAPH False True Condensation of Prometaphase Chromosomes;Condensation of Prometaphase Chromosomes 23400 ATP13A2 False True Ion transport by P-type ATPases 23405 DICER1 False True MicroRNA (miRNA) biogenesis;Small interfering RNA (siRNA) biogenesis 23411 SIRT1 False True Regulation of HSF1-mediated heat shock response;Circadian Clock;SIRT1 negatively regulates rRNA expression;SIRT1 negatively regulates rRNA expression;Regulation of FOXO transcriptional activity by acetylation;Regulation of FOXO transcriptional activity by acetylation 23418 NA False True NA 23429 RYBP False True RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known;Transcriptional Regulation by E2F6 23431 AP4E1 False True Lysosome Vesicle Biogenesis;Golgi Associated Vesicle Biogenesis 23435 TARDBP False True NA 23446 NA False True Synthesis of PC;Transport of bile salts and organic acids, metal ions and amine compounds;Choline catabolism 23450 SF3B3 False True mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway 23451 SF3B1 False True B-WICH complex positively regulates rRNA expression;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway 23468 CBX5 False True SUMOylation of chromatin organization proteins;Transcriptional Regulation by E2F6;Factors involved in megakaryocyte development and platelet production 23469 NA False True NA 23476 BRD4 False True NA 23479 ISCU False True Mitochondrial iron-sulfur cluster biogenesis 23481 PES1 False True Major pathway of rRNA processing in the nucleolus and cytosol 23484 NA False True NA 23499 MACF1 False True NA 23503 ZFYVE26 False True NA 23509 POFUT1 False True Pre-NOTCH Processing in the Endoplasmic Reticulum 23513 SCRIB False True Asymmetric localization of PCP proteins 23517 SKIV2L2 False True Major pathway of rRNA processing in the nucleolus and cytosol;mRNA Splicing - Major Pathway 23521 RPL13A False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 23524 SRRM2 False True mRNA Splicing - Major Pathway 23526 NA False True Rho GTPase cycle;Neutrophil degranulation 23527 ACAP2 False True NA 23534 TNPO3 False True NA 23543 RBFOX2 False True FGFR2 alternative splicing 23566 LPAR3 False True G alpha (q) signalling events;G alpha (i) signalling events;Lysosphingolipid and LPA receptors 23576 NA False True eNOS activation 23581 CASP14 True True Formation of the cornified envelope 23582 CCNDBP1 False True NA 23588 KLHDC2 False True NA 23589 CARHSP1 False True NA 23592 NA False True Clearance of Nuclear Envelope Membranes from Chromatin;Initiation of Nuclear Envelope Reformation;Depolymerisation of the Nuclear Lamina 23597 NA False True Mitochondrial Fatty Acid Beta-Oxidation 23603 CORO1C False True NA 23607 CD2AP False True Nephrin family interactions 23617 TSSK2 False True NA 23633 KPNA6 False True NA 23636 NUP62 False True ISG15 antiviral mechanism;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Rev-mediated nuclear export of HIV RNA;Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Viral Messenger RNA Synthesis;NEP/NS2 Interacts with the Cellular Export Machinery;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;snRNP Assembly;SUMOylation of DNA damage response and repair proteins;SUMOylation of ubiquitinylation proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;SUMOylation of SUMOylation proteins;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins;Transcriptional regulation by small RNAs;tRNA processing in the nucleus 23640 HSPBP1 False True NA 23641 LDOC1 False True NA 23644 EDC4 False True mRNA decay by 5' to 3' exoribonuclease 23647 ARFIP2 False True Retrograde transport at the Trans-Golgi-Network 23649 POLA2 False True Inhibition of replication initiation of damaged DNA by RB1/E2F1;Polymerase switching on the C-strand of the telomere;Telomere C-strand synthesis initiation;DNA replication initiation;Activation of the pre-replicative complex;Polymerase switching;Removal of the Flap Intermediate;Processive synthesis on the lagging strand 23673 STX12 False True NA 23677 SH3BP4 False True NA 23678 SGK3 False True Stimuli-sensing channels 23708 GSPT2 False True Eukaryotic Translation Termination;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 23731 NA False True NA 23760 NA False True PI and PC transport between ER and Golgi membranes 23770 FKBP8 False True Ub-specific processing proteases 23780 APOL2 False True NA 23787 MTCH1 False True NA 23788 MTCH2 False True NA 24144 TFIP11 False True mRNA Splicing - Major Pathway 24148 PRPF6 False True mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway 25747 Ppara False True NA 25776 CBY1 False True Deactivation of the beta-catenin transactivating complex 25793 FBXO7 False True Neddylation;Antigen processing: Ubiquitination & Proteasome degradation 25801 GCA False True Neutrophil degranulation 25813 SAMM50 False True Mitochondrial protein import;Cristae formation 25814 ATXN10 False True NA 25816 TNFAIP8 False True PI Metabolism 25820 ARIH1 False True ISG15 antiviral mechanism 25822 DNAJB5 False True NA 25824 PRDX5 False True Detoxification of Reactive Oxygen Species;TP53 Regulates Metabolic Genes 25827 FBXL2 False True NA 25831 HECTD1 False True Antigen processing: Ubiquitination & Proteasome degradation 25843 MOB4 False True NA 25864 ABHD14A False True NA 25865 PRKD2 False True Sphingolipid de novo biosynthesis 25873 RPL36 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 25875 LETMD1 False True NA 25885 POLR1A False True NoRC negatively regulates rRNA expression;B-WICH complex positively regulates rRNA expression;RNA Polymerase I Transcription Initiation;RNA Polymerase I Transcription Initiation;RNA Polymerase I Promoter Escape;RNA Polymerase I Chain Elongation;RNA Polymerase I Transcription Termination 25898 RCHY1 False True Translesion Synthesis by POLH;Antigen processing: Ubiquitination & Proteasome degradation 25900 IFFO1 False True NA 25909 AHCTF1 False True Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase 25913 POT1 False True Meiotic synapsis;Packaging Of Telomere Ends;DNA Damage/Telomere Stress Induced Senescence 25930 PTPN23 False True Interleukin-37 signaling 25936 NSL1 False True Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase 25937 WWTR1 False True Signaling by Hippo;YAP1- and WWTR1 (TAZ)-stimulated gene expression;YAP1- and WWTR1 (TAZ)-stimulated gene expression;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;Physiological factors;RUNX2 regulates osteoblast differentiation;RUNX3 regulates YAP1-mediated transcription 25943 NA False True NA 25957 PNISR False True NA 25972 NA False True NA 25984 NA True False Keratinization;Formation of the cornified envelope 25994 HIGD1A False True Regulation of gene expression by Hypoxia-inducible Factor 25996 REXO2 False True NA 25998 IBTK False True NA 26003 GORASP2 False True Golgi Cisternae Pericentriolar Stack Reorganization 26020 LRP10 False True Retinoid metabolism and transport 26030 NA False True NA 26031 OSBPL3 False True Synthesis of bile acids and bile salts 26032 NA False True NA 26037 SIPA1L1 False True Neurexins and neuroligins 26049 NA False True NA 26052 DNM3 False True Toll Like Receptor 4 (TLR4) Cascade;Retrograde neurotrophin signalling;MHC class II antigen presentation;Recycling pathway of L1;Clathrin-mediated endocytosis 26054 SENP6 False True NA 26057 ANKRD17 False True NA 26058 GIGYF2 False True NA 26064 RAI14 False True NA 26073 POLDIP2 False True NA 26088 GGA1 False True TBC/RABGAPs;Amyloid fiber formation 26091 HERC4 False True Antigen processing: Ubiquitination & Proteasome degradation 26092 TOR1AIP1 False True NA 26097 CHTOP False True Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA 3'-end processing 26098 EDRF1 False True NA 26099 SZRD1 False True NA 26112 CCDC69 False True NA 26121 PRPF31 False True mRNA Splicing - Major Pathway 26128 KIAA1279 False True NA 26130 GAPVD1 False True Clathrin-mediated endocytosis;RAB GEFs exchange GTP for GDP on RABs 26135 SERBP1 False True NA 26136 TES False True NA 26137 NA False True NA 26146 TRAF3IP1 False True Intraflagellar transport;Intraflagellar transport 26150 RIBC2 False True NA 26156 RSL1D1 False True NA 26164 MTG2 False True NA 26165 NA False True NA 26168 SENP3 False True Major pathway of rRNA processing in the nucleolus and cytosol 26190 FBXW2 False True Association of TriC/CCT with target proteins during biosynthesis;Neddylation;Antigen processing: Ubiquitination & Proteasome degradation 26224 FBXL3 False True Association of TriC/CCT with target proteins during biosynthesis;Circadian Clock;Neddylation;Antigen processing: Ubiquitination & Proteasome degradation 26227 PHGDH False True Serine biosynthesis 26258 BLOC1S6 False True Golgi Associated Vesicle Biogenesis 26260 FBXO25 False True NA 26261 FBXO24 False True NA 26267 FBXO10 False True Neddylation;Antigen processing: Ubiquitination & Proteasome degradation 26268 FBXO9 False True Neddylation;Antigen processing: Ubiquitination & Proteasome degradation 26270 FBXO6 False True Association of TriC/CCT with target proteins during biosynthesis;Neddylation;Antigen processing: Ubiquitination & Proteasome degradation 26271 FBXO5 False True SCF-beta-TrCP mediated degradation of Emi1;Regulation of APC/C activators between G1/S and early anaphase;Phosphorylation of Emi1;Activation of E2F1 target genes at G1/S;Mitotic Metaphase/Anaphase Transition 26272 FBXO4 False True Association of TriC/CCT with target proteins during biosynthesis;Neddylation;Antigen processing: Ubiquitination & Proteasome degradation 26273 FBXO3 False True NA 26275 HIBCH False True Branched-chain amino acid catabolism 26278 SACS False True NA 26285 NA False True Tight junction interactions 26330 GAPDHS False True Association of TriC/CCT with target proteins during biosynthesis;Glycolysis;Gluconeogenesis 26470 SEZ6L2 False True NA 26502 NARF False True NA 26509 MYOF False True NA 26517 TIMM13 False True Mitochondrial protein import 26524 LATS2 False True Signaling by Hippo 26528 DAZAP1 False True NA 26576 SRPK3 False True NA 26578 OSTF1 False True Neutrophil degranulation 26589 MRPL46 False True Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation elongation;Mitochondrial translation termination 26750 RPS6KC1 False True NA 26973 CHORDC1 False True NA 26984 SEC22A False True COPII-mediated vesicle transport 26985 AP3M1 False True Association of TriC/CCT with target proteins during biosynthesis 26986 PABPC1 False True L13a-mediated translational silencing of Ceruloplasmin expression;Deadenylation of mRNA;AUF1 (hnRNP D0) binds and destabilizes mRNA;Translation initiation complex formation;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 26993 AKAP8L False True NA 26998 NA False True NA 26999 CYFIP2 False True Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;VEGFA-VEGFR2 Pathway;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs 27000 DNAJC2 False True Regulation of HSF1-mediated heat shock response 27018 NGFRAP1 False True NADE modulates death signalling 27040 LAT False True GPVI-mediated activation cascade;Generation of second messenger molecules;DAP12 signaling;Fc epsilon receptor (FCERI) signaling;FCERI mediated MAPK activation;FCERI mediated Ca+2 mobilization;FCERI mediated Ca+2 mobilization;RAF/MAP kinase cascade 27044 SND1 False True Signaling by BRAF and RAF fusions 27069 GHITM False True NA 27072 VPS41 False True NA 27076 LYPD3 True True Post-translational modification: synthesis of GPI-anchored proteins 27095 TRAPPC3 False True COPII-mediated vesicle transport;RAB GEFs exchange GTP for GDP on RABs 27101 CACYBP False True NA 27102 EIF2AK1 False True NA 27107 NA False True NA 27109 NA False True Formation of ATP by chemiosmotic coupling;Cristae formation 27113 BBC3 False True BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members;Activation of PUMA and translocation to mitochondria;TP53 Regulates Transcription of Genes Involved in Cytochrome C Release;FOXO-mediated transcription of cell death genes 27128 CYTH4 False True Intra-Golgi traffic 27143 NA False True NA 27153 NA False True Generic Transcription Pathway 27229 TUBGCP4 False True Recruitment of mitotic centrosome proteins and complexes;Recruitment of NuMA to mitotic centrosomes 27230 SERP1 False True XBP1(S) activates chaperone genes 27236 ARFIP1 False True NA 27237 ARHGEF16 False True NRAGE signals death through JNK;Rho GTPase cycle;G alpha (12/13) signalling events 27238 GPKOW False True mRNA Splicing - Major Pathway 27245 AHDC1 False True NA 27246 RNF115 False True Antigen processing: Ubiquitination & Proteasome degradation 27247 NFU1 False True NA 27248 ERLEC1 False True ABC-family proteins mediated transport;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Defective CFTR causes cystic fibrosis 27250 PDCD4 False True Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 27258 LSM3 False True mRNA decay by 5' to 3' exoribonuclease;mRNA decay by 5' to 3' exoribonuclease;mRNA Splicing - Major Pathway 27295 NA False True NA 27316 RBMX False True mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA 27330 RPS6KA6 False True Recycling pathway of L1;CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling;RSK activation;RSK activation 27332 ZNF638 False True Transcriptional regulation of white adipocyte differentiation 27335 EIF3K False True L13a-mediated translational silencing of Ceruloplasmin expression;Translation initiation complex formation;Formation of a pool of free 40S subunits;Formation of the ternary complex, and subsequently, the 43S complex;Ribosomal scanning and start codon recognition;GTP hydrolysis and joining of the 60S ribosomal subunit 27339 PRPF19 False True Formation of TC-NER Pre-Incision Complex;Transcription-Coupled Nucleotide Excision Repair (TC-NER);Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;mRNA Splicing - Major Pathway 27347 STK39 False True NA 27430 MAT2B False True Methylation;Ub-specific processing proteases 28916 NA False True NA 28952 CCDC22 False True Neddylation 28954 REM1 False True NA 28957 MRPS28 False True Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation elongation;Mitochondrial translation termination 28960 DCPS False True mRNA decay by 3' to 5' exoribonuclease 28969 BZW2 False True NA 28970 C11orf54 False True NA 28972 NA False True SRP-dependent cotranslational protein targeting to membrane;Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1);Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP);Synthesis, secretion, and deacylation of Ghrelin 28973 MRPS18B False True Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation elongation;Mitochondrial translation termination 28978 TMEM14A False True NA 28982 NA False True Iron uptake and transport 28985 MCTS1 False True NA 29058 NA False True NA 29082 CHMP4A False True Budding and maturation of HIV virion;Macroautophagy;Endosomal Sorting Complex Required For Transport (ESCRT) 29099 COMMD9 False True Neutrophil degranulation;Neddylation 29100 NA False True NA 29104 N6AMT1 False True Methylation;Eukaryotic Translation Termination 29109 FHOD1 False True NA 29110 TBK1 False True IRF3 mediated activation of type 1 IFN;IRF3 mediated activation of type 1 IFN;Regulation of innate immune responses to cytosolic DNA;STAT6-mediated induction of chemokines;IRF3-mediated induction of type I IFN;Interleukin-37 signaling;TICAM1-dependent activation of IRF3/IRF7;TRAF3-dependent IRF activation pathway;TRAF6 mediated IRF7 activation;Negative regulators of DDX58/IFIH1 signaling;Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon 29114 TAGLN3 False True NA 29115 SAP30BP False True NoRC negatively regulates rRNA expression 29119 CTNNA3 False True NA 29127 RACGAP1 False True Rho GTPase cycle;MHC class II antigen presentation;COPI-dependent Golgi-to-ER retrograde traffic;Kinesins 29128 UHRF1 False True DNA methylation 29763 PACSIN3 False True Clathrin-mediated endocytosis 29766 TMOD3 False True Striated Muscle Contraction 29785 CYP2S1 False True Miscellaneous substrates;Xenobiotics;CYP2E1 reactions 29789 OLA1 False True Platelet degranulation 29843 SENP1 False True SUMO is proteolytically processed 29882 ANAPC2 False True Inactivation of APC/C via direct inhibition of the APC/C complex;APC/C:Cdc20 mediated degradation of Cyclin B;Autodegradation of Cdh1 by Cdh1:APC/C;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase;Regulation of APC/C activators between G1/S and early anaphase;APC/C:Cdc20 mediated degradation of mitotic proteins;Phosphorylation of the APC/C;APC-Cdc20 mediated degradation of Nek2A;Separation of Sister Chromatids;Senescence-Associated Secretory Phenotype (SASP);CDK-mediated phosphorylation and removal of Cdc6;Antigen processing: Ubiquitination & Proteasome degradation 29889 GNL2 False True NA 29894 CPSF1 False True Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA Derived from an Intronless Transcript;tRNA processing in the nucleus;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Processing of Intronless Pre-mRNAs 29896 TRA2A False True NA 29926 GMPPA False True Synthesis of GDP-mannose 29927 SEC61A1 False True ER-Phagosome pathway;SRP-dependent cotranslational protein targeting to membrane;XBP1(S) activates chaperone genes 29941 PKN3 False True RHO GTPases activate PKNs 29944 NA False True NA 29950 SERTAD1 False True NA 29951 NA False True NA 29968 PSAT1 False True Serine biosynthesis 29978 UBQLN2 False True Cargo recognition for clathrin-mediated endocytosis 29979 UBQLN1 False True Cargo recognition for clathrin-mediated endocytosis 29980 DONSON False True NA 30000 TNPO2 False True NA 30011 SH3KBP1 False True EGFR downregulation;Negative regulation of MET activity;Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis;Reelin signalling pathway;InlB-mediated entry of Listeria monocytogenes into host cell;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 30817 NA False True Class B/2 (Secretin family receptors) 30827 CXXC1 False True XBP1(S) activates chaperone genes 30834 ZNRD1 False True NoRC negatively regulates rRNA expression;B-WICH complex positively regulates rRNA expression;RNA Polymerase I Transcription Initiation;RNA Polymerase I Transcription Initiation;RNA Polymerase I Promoter Escape;RNA Polymerase I Chain Elongation;RNA Polymerase I Transcription Termination 30849 NA False True PI3K Cascade;Macroautophagy;Synthesis of PIPs at the Golgi membrane;Synthesis of PIPs at the early endosome membrane;Synthesis of PIPs at the late endosome membrane;Toll Like Receptor 9 (TLR9) Cascade;RHO GTPases Activate NADPH Oxidases 30850 CDR2L False True NA 30851 TAX1BP3 False True RHO GTPases Activate Rhotekin and Rhophilins 30968 STOML2 False True Processing of SMDT1 33226 NA False True NA 50488 MINK1 False True Oxidative Stress Induced Senescence 50489 CD207 False True Cross-presentation of soluble exogenous antigens (endosomes);Cross-presentation of soluble exogenous antigens (endosomes) 50515 NA False True Chondroitin sulfate biosynthesis 50717 DCAF8 False True Neddylation 50809 HP1BP3 False True NA 50855 PARD6A False True TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);Tight junction interactions;Asymmetric localization of PCP proteins 50856 NA False True Dectin-2 family 50945 TBX22 False True NA 51002 TPRKB False True tRNA modification in the nucleus and cytosol 51003 MED31 False True PPARA activates gene expression;Generic Transcription Pathway;Transcriptional regulation of white adipocyte differentiation;Transcriptional regulation of white adipocyte differentiation 51005 AMDHD2 False True Synthesis of UDP-N-acetyl-glucosamine 51008 ASCC1 False True ALKBH3 mediated reversal of alkylation damage 51009 DERL2 False True ABC-family proteins mediated transport;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Defective CFTR causes cystic fibrosis;ER Quality Control Compartment (ERQC) 51011 FAHD2A False True NA 51015 ISOC1 False True NA 51019 CCDC53 False True NA 51026 GOLT1B False True NA 51031 GLOD4 False True NA 51035 UBXN1 False True N-glycan trimming in the ER and Calnexin/Calreticulin cycle 51061 TXNDC11 False True NA 51068 NMD3 False True NA 51077 FCF1 False True rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol 51078 THAP4 False True NA 51086 TNNI3K False True NA 51090 PLLP False True NA 51100 SH3GLB1 False True NA 51110 LACTB2 False True NA 51119 SBDS False True NA 51121 RPL26L1 False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 51127 TRIM17 False True Interferon gamma signaling 51130 ASB3 False True Neddylation;Antigen processing: Ubiquitination & Proteasome degradation 51133 KCTD3 False True NA 51134 CEP83 False True Anchoring of the basal body to the plasma membrane 51141 INSIG2 False True Regulation of cholesterol biosynthesis by SREBP (SREBF) 51142 CHCHD2 False True Mitochondrial protein import 51148 CERCAM False True NA 51150 SDF4 False True NA 51155 HN1 False True NA 51196 PLCE1 False True Synthesis of IP3 and IP4 in the cytosol 51200 CPA4 True True NA 51207 DUSP13 False True NA 51218 GLRX5 False True Mitochondrial iron-sulfur cluster biogenesis 51225 ABI3 False True NA 51248 PDZD11 False True Biotin transport and metabolism;Vitamin B5 (pantothenate) metabolism;Transport of vitamins, nucleosides, and related molecules;Ion influx/efflux at host-pathogen interface;Ion transport by P-type ATPases 51253 MRPL37 False True Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation elongation;Mitochondrial translation termination 51255 RNF181 False True E3 ubiquitin ligases ubiquitinate target proteins 51267 CLEC1A False True NA 51270 TFDP3 False True NA 51271 UBAP1 False True Budding and maturation of HIV virion;Membrane binding and targetting of GAG proteins;Endosomal Sorting Complex Required For Transport (ESCRT) 51295 ECSIT False True MyD88:MAL(TIRAP) cascade initiated on plasma membrane;Complex I biogenesis;TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation;MyD88 cascade initiated on plasma membrane 51306 NA False True Rho GTPase cycle 51307 FAM53C False True NA 51317 PHF21A False True HDACs deacetylate histones;Factors involved in megakaryocyte development and platelet production 51322 WAC False True E3 ubiquitin ligases ubiquitinate target proteins 51324 SPG21 False True NA 51340 CRNKL1 False True mRNA Splicing - Major Pathway 51343 FZR1 False True Autodegradation of Cdh1 by Cdh1:APC/C;SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase;Regulation of APC/C activators between G1/S and early anaphase;Phosphorylation of Emi1;Senescence-Associated Secretory Phenotype (SASP);CDK-mediated phosphorylation and removal of Cdc6;Cyclin A:Cdk2-associated events at S phase entry;Antigen processing: Ubiquitination & Proteasome degradation 51347 TAOK3 False True NA 51360 MBTPS2 False True Regulation of cholesterol biosynthesis by SREBP (SREBF);ATF6 (ATF6-alpha) activates chaperones;CREB3 factors activate genes;CREB3 factors activate genes;Assembly of active LPL and LIPC lipase complexes 51371 POMP False True NA 51377 UCHL5 False True Downregulation of TGF-beta receptor signaling;UCH proteinases;UCH proteinases 51380 NA False True Degradation of cysteine and homocysteine 51390 AIG1 False True NA 51399 TRAPPC4 False True COPII-mediated vesicle transport;Syndecan interactions;RAB GEFs exchange GTP for GDP on RABs 51400 PPME1 False True Cyclin A/B1/B2 associated events during G2/M transition 51421 AMOTL2 False True Signaling by Hippo 51434 ANAPC7 False True Inactivation of APC/C via direct inhibition of the APC/C complex;APC/C:Cdc20 mediated degradation of Cyclin B;Autodegradation of Cdh1 by Cdh1:APC/C;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase;Regulation of APC/C activators between G1/S and early anaphase;APC/C:Cdc20 mediated degradation of mitotic proteins;Phosphorylation of the APC/C;APC-Cdc20 mediated degradation of Nek2A;Separation of Sister Chromatids;Senescence-Associated Secretory Phenotype (SASP);CDK-mediated phosphorylation and removal of Cdc6;Antigen processing: Ubiquitination & Proteasome degradation 51435 SCARA3 False True NA 51455 REV1 False True Translesion synthesis by REV1;Translesion synthesis by POLK;Translesion synthesis by POLI;Termination of translesion DNA synthesis 51474 LIMA1 False True NA 51477 ISYNA1 False True Synthesis of IP2, IP, and Ins in the cytosol 51490 C9orf114 False True NA 51506 UFC1 False True NA 51512 GTSE1 False True G2/M Checkpoints;The role of GTSE1 in G2/M progression after G2 checkpoint 51514 DTL False True Recognition of DNA damage by PCNA-containing replication complex;Neddylation 51517 NCKIPSD False True Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs 51520 LARS False True SeMet incorporation into proteins;Cytosolic tRNA aminoacylation 51522 TMEM14C False True NA 51526 OSER1 False True NA 51530 ZC3HC1 False True NA 51531 C9orf156 False True NA 51535 PPHLN1 False True NA 51540 SCLY False True Metabolism of ingested SeMet, Sec, MeSec into H2Se 51552 RAB14 False True Translocation of SLC2A4 (GLUT4) to the plasma membrane;Synthesis of PIPs at the plasma membrane;Neutrophil degranulation;RAB geranylgeranylation;RAB GEFs exchange GTP for GDP on RABs 51560 RAB6B False True COPI-independent Golgi-to-ER retrograde traffic;Retrograde transport at the Trans-Golgi-Network;TBC/RABGAPs;RAB geranylgeranylation;RAB GEFs exchange GTP for GDP on RABs 51564 HDAC7 False True NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;SUMOylation of DNA damage response and repair proteins;Regulation of PTEN gene transcription 51569 UFM1 False True NA 51571 FAM49B False True Platelet degranulation 51574 LARP7 False True NA 51588 PIAS4 False True Vitamin D (calciferol) metabolism;SUMOylation of DNA damage response and repair proteins;SUMOylation of transcription factors;SUMOylation of ubiquitinylation proteins;SUMOylation of transcription cofactors;SUMOylation of SUMOylation proteins;SUMOylation of intracellular receptors;SUMOylation of intracellular receptors;SUMOylation of DNA replication proteins;SUMOylation of immune response proteins;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Processing of DNA double-strand break ends;G2/M DNA damage checkpoint 51593 SRRT False True RNA polymerase II transcribes snRNA genes;mRNA Splicing - Major Pathway 51594 NA False True COPI-dependent Golgi-to-ER retrograde traffic 51596 CUTA False True NA 51599 LSR False True LDL clearance;VLDL clearance 51602 NOP58 False True SUMOylation of RNA binding proteins;rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol 51603 METTL13 False True NA 51606 ATP6V1H False True ROS, RNS production in phagocytes;Nef Mediated CD4 Down-regulation;Nef Mediated CD8 Down-regulation;Insulin receptor recycling;Transferrin endocytosis and recycling;Ion channel transport 51611 DPH5 False True Synthesis of diphthamide-EEF2 51629 NA False True NA 51631 LUC7L2 False True NA 51637 C14orf166 False True tRNA processing in the nucleus 51639 SF3B6 False True mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway 51649 MRPS23 False True Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation elongation;Mitochondrial translation termination 51651 PTRH2 False True Ub-specific processing proteases 51659 GINS2 False True Unwinding of DNA;Unwinding of DNA 51661 FKBP7 False True NA 51663 ZFR False True NA 51666 ASB4 False True Neddylation;Antigen processing: Ubiquitination & Proteasome degradation 51676 ASB2 False True Neddylation;Antigen processing: Ubiquitination & Proteasome degradation 51692 CPSF3 False True Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA Derived from an Intronless Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Processing of Intronless Pre-mRNAs 51714 NA False True NA 51725 FBXO40 False True Neddylation;Antigen processing: Ubiquitination & Proteasome degradation 51726 DNAJB11 False True XBP1(S) activates chaperone genes 51735 RAPGEF6 False True NA 51741 WWOX False True Nuclear signaling by ERBB4;Negative regulation of activity of TFAP2 (AP-2) family transcription factors;Activation of the TFAP2 (AP-2) family of transcription factors 51747 LUC7L3 False True NA 51752 ERAP1 False True Antigen Presentation: Folding, assembly and peptide loading of class I MHC 51759 C9orf78 False True NA 51763 INPP5K False True Synthesis of PIPs at the plasma membrane 51776 ZAK False True NA 51778 MYOZ2 False True NA 51780 KDM3B False True HDMs demethylate histones 51806 NA True False Neutrophil degranulation 53371 NUP54 False True ISG15 antiviral mechanism;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Rev-mediated nuclear export of HIV RNA;Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Viral Messenger RNA Synthesis;NEP/NS2 Interacts with the Cellular Export Machinery;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;snRNP Assembly;SUMOylation of DNA damage response and repair proteins;SUMOylation of ubiquitinylation proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;SUMOylation of SUMOylation proteins;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins;Transcriptional regulation by small RNAs;tRNA processing in the nucleus 53615 MBD3 False True HDACs deacetylate histones;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;Regulation of TP53 Activity through Acetylation;RNA Polymerase I Transcription Initiation;Regulation of PTEN gene transcription;Regulation of PTEN gene transcription 53635 PTOV1 False True NA 53826 FXYD6 False True Ion homeostasis;Ion transport by P-type ATPases 53838 C11orf24 False True NA 53918 PELO False True NA 53938 PPIL3 False True mRNA Splicing - Major Pathway 53981 CPSF2 False True Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA Derived from an Intronless Transcript;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Processing of Intronless Pre-mRNAs 54065 SMIM11 False True NA 54107 POLE3 False True Recognition of DNA damage by PCNA-containing replication complex;Telomere C-strand synthesis initiation;PCNA-Dependent Long Patch Base Excision Repair;Termination of translesion DNA synthesis;HDR through Homologous Recombination (HRR);Gap-filling DNA repair synthesis and ligation in GG-NER;Dual Incision in GG-NER;Dual incision in TC-NER;Gap-filling DNA repair synthesis and ligation in TC-NER;DNA replication initiation;Activation of the pre-replicative complex 54187 NANS False True Sialic acid metabolism 54205 CYCS False True Release of apoptotic factors from the mitochondria;Formation of apoptosome;Activation of caspases through apoptosome-mediated cleavage;SMAC (DIABLO) binds to IAPs ;SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ;Transcriptional activation of mitochondrial biogenesis;Detoxification of Reactive Oxygen Species;TP53 Regulates Metabolic Genes;Respiratory electron transport;Regulation of the apoptosome activity;Regulation of the apoptosome activity 54206 ERRFI1 False True NA 54431 DNAJC10 False True NA 54432 YIPF1 False True NA 54433 GAR1 False True rRNA modification in the nucleus and cytosol 54439 RBM27 False True NA 54443 ANLN False True NA 54458 PRR13 False True NA 54460 MRPS21 False True Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation elongation;Mitochondrial translation termination 54461 FBXW5 False True Association of TriC/CCT with target proteins during biosynthesis;Neddylation;Antigen processing: Ubiquitination & Proteasome degradation 54468 MIOS False True NA 54474 KRT20 False True Keratinization;Formation of the cornified envelope 54478 FAM64A False True NA 54507 ADAMTSL4 False True Defective B3GALTL causes Peters-plus syndrome (PpS);O-glycosylation of TSR domain-containing proteins 54509 RHOF False True Rho GTPase cycle;Neutrophil degranulation 54512 EXOSC4 False True ATF4 activates genes;mRNA decay by 3' to 5' exoribonuclease;Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA;Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA;KSRP (KHSRP) binds and destabilizes mRNA;Major pathway of rRNA processing in the nucleolus and cytosol 54517 PUS7 False True tRNA modification in the nucleus and cytosol 54535 CCHCR1 False True NA 54536 EXOC6 False True Translocation of SLC2A4 (GLUT4) to the plasma membrane;Insulin processing;VxPx cargo-targeting to cilium 54539 NDUFB11 False True Respiratory electron transport;Complex I biogenesis 54541 DDIT4 False True TP53 Regulates Metabolic Genes 54552 GNL3L False True NA 54566 EPB41L4B False True NA 54583 EGLN1 False True Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 54585 LZTFL1 False True BBSome-mediated cargo-targeting to cilium 54617 INO80 False True UCH proteinases;DNA Damage Recognition in GG-NER 54623 PAF1 False True Formation of RNA Pol II elongation complex ;RNA Polymerase II Pre-transcription Events;RNA Polymerase II Transcription Elongation;E3 ubiquitin ligases ubiquitinate target proteins 54677 CROT False True Beta-oxidation of pristanoyl-CoA;Peroxisomal protein import;Peroxisomal protein import 54708 MARCH5 False True NA 54737 MPHOSPH8 False True NA 54749 NA False True NA 54751 FBLIM1 False True Cell-extracellular matrix interactions 54778 RNF111 False True Downregulation of SMAD2/3:SMAD4 transcriptional activity;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;Formation of Incision Complex in GG-NER;Antigen processing: Ubiquitination & Proteasome degradation 54780 NSMCE4A False True SUMOylation of DNA damage response and repair proteins 54788 DNAJB12 False True NA 54814 QPCTL False True NA 54826 NA False True NA 54850 FBXL12 False True Neddylation;Antigen processing: Ubiquitination & Proteasome degradation 54852 PAQR5 False True NA 54859 ELP6 False True HATs acetylate histones 54867 NA False True NA 54870 QRICH1 False True NA 54888 NSUN2 False True tRNA modification in the nucleus and cytosol;tRNA modification in the nucleus and cytosol 54901 CDKAL1 False True tRNA modification in the nucleus and cytosol 54903 MKS1 False True Hedgehog 'off' state;Anchoring of the basal body to the plasma membrane 54919 DNAAF5 False True NA 54936 ADPRHL2 False True POLB-Dependent Long Patch Base Excision Repair 54948 MRPL16 False True Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation elongation;Mitochondrial translation termination 54955 C1orf109 False True NA 54962 TIPIN False True Processing of DNA double-strand break ends 54971 BANP False True Regulation of TP53 Activity through Association with Co-factors 54982 CLN6 False True NA 54987 C1orf123 False True NA 55002 TMCO3 False True NA 55008 HERC6 False True Antigen processing: Ubiquitination & Proteasome degradation 55010 PARPBP False True NA 55011 PIH1D1 False True NA 55012 PPP2R3C False True NA 55027 NA False True NA 55030 FBXO34 False True NA 55048 VPS37C False True Budding and maturation of HIV virion;Membrane binding and targetting of GAG proteins;Endosomal Sorting Complex Required For Transport (ESCRT) 55052 MRPL20 False True Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation elongation;Mitochondrial translation termination 55066 NA False True Regulation of pyruvate dehydrogenase (PDH) complex 55070 DET1 False True Antigen processing: Ubiquitination & Proteasome degradation 55075 UACA False True Regulation of the apoptosome activity 55092 TMEM51 False True NA 55093 WDYHV1 False True NA 55094 GPATCH1 False True NA 55095 SAMD4B False True NA 55100 WDR70 False True NA 55103 RALGPS2 False True NA 55108 BSDC1 False True NA 55114 ARHGAP17 False True Rho GTPase cycle 55119 NA False True NA 55122 AKIRIN2 False True NA 55124 PIWIL2 False True PIWI-interacting RNA (piRNA) biogenesis 55125 CEP192 False True Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;AURKA Activation by TPX2 55127 HEATR1 False True rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol 55139 ANKZF1 False True NA 55143 CDCA8 False True Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;SUMOylation of DNA replication proteins;RHO GTPases Activate Formins;Mitotic Prometaphase 55149 MTPAP False True NA 55153 NA False True NA 55154 MSTO1 False True NA 55159 RFWD3 False True NA 55165 CEP55 False True NA 55167 MSL2 False True HATs acetylate histones 55177 RMDN3 False True NA 55179 NA False True NA 55183 RIF1 False True Nonhomologous End-Joining (NHEJ) 55192 DNAJC17 False True NA 55197 RPRD1A False True RNA polymerase II transcribes snRNA genes;RNA polymerase II transcribes snRNA genes 55210 ATAD3A False True NA 55213 RCBTB1 False True NA 55223 TRIM62 False True Interferon gamma signaling 55229 PANK4 False True Coenzyme A biosynthesis 55231 CCDC87 False True NA 55236 UBA6 False True Synthesis of active ubiquitin: roles of E1 and E2 enzymes;Synthesis of active ubiquitin: roles of E1 and E2 enzymes;Antigen processing: Ubiquitination & Proteasome degradation 55238 SLC38A7 False True NA 55257 MRGBP False True HATs acetylate histones 55272 IMP3 False True rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol 55276 PGM2 False True Glycogen synthesis;Neutrophil degranulation;Glycogen breakdown (glycogenolysis);Galactose catabolism;Pentose phosphate pathway 55281 TMEM140 False True NA 55290 BRF2 False True RNA Polymerase III Abortive And Retractive Initiation;RNA Polymerase III Transcription Initiation From Type 3 Promoter;RNA Polymerase III Transcription Initiation From Type 3 Promoter 55294 FBXW7 False True NOTCH1 Intracellular Domain Regulates Transcription;Constitutive Signaling by NOTCH1 PEST Domain Mutants;Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;Association of TriC/CCT with target proteins during biosynthesis;Regulation of RUNX2 expression and activity;Neddylation;Negative regulation of NOTCH4 signaling;Antigen processing: Ubiquitination & Proteasome degradation 55295 NA False True NA 55324 ABCF3 False True NA 55326 NA False True Synthesis of PA 55336 FBXL8 False True Neddylation;Antigen processing: Ubiquitination & Proteasome degradation 55351 NA False True NA 55353 LAPTM4B False True NA 55359 NA False True NA 55379 LRRC59 False True NA 55388 MCM10 False True Activation of ATR in response to replication stress;Activation of the pre-replicative complex 55454 CSGALNACT2 False True Chondroitin sulfate biosynthesis 55466 DNAJA4 False True HSP90 chaperone cycle for steroid hormone receptors (SHR) 55505 NOP10 False True rRNA modification in the nucleus and cytosol 55510 DDX43 False True NA 55521 TRIM36 False True Antigen processing: Ubiquitination & Proteasome degradation 55561 CDC42BPG False True NA 55568 NA False True O-linked glycosylation of mucins 55585 UBE2Q1 False True Antigen processing: Ubiquitination & Proteasome degradation 55588 MED29 False True PPARA activates gene expression;Transcriptional regulation of white adipocyte differentiation;Transcriptional regulation of white adipocyte differentiation 55589 NA False True NA 55602 CDKN2AIP False True NA 55609 NA False True NA 55611 OTUB1 False True Ub-specific processing proteases;Ovarian tumor domain proteases 55632 G2E3 False True NA 55644 OSGEP False True tRNA modification in the nucleus and cytosol 55651 NHP2 False True Telomere Extension By Telomerase;rRNA modification in the nucleus and cytosol 55660 PRPF40A False True mRNA Splicing - Major Pathway 55664 CDC37L1 False True Platelet degranulation 55665 URGCP False True NA 55666 NPLOC4 False True Translesion Synthesis by POLH 55671 SMEK1 False True NA 55677 IWS1 False True Formation of RNA Pol II elongation complex ;RNA Polymerase II Pre-transcription Events;RNA Polymerase II Transcription Elongation 55679 LIMS2 False True Cell-extracellular matrix interactions 55681 SCYL2 False True NA 55699 IARS2 False True Mitochondrial tRNA aminoacylation 55706 NA False True ISG15 antiviral mechanism;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Rev-mediated nuclear export of HIV RNA;Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Viral Messenger RNA Synthesis;NEP/NS2 Interacts with the Cellular Export Machinery;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;snRNP Assembly;SUMOylation of DNA damage response and repair proteins;SUMOylation of ubiquitinylation proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;SUMOylation of SUMOylation proteins;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins;Transcriptional regulation by small RNAs;tRNA processing in the nucleus 55707 NECAP2 False True Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis 55709 KBTBD4 False True NA 55714 NA False True NA 55720 TSR1 False True Major pathway of rRNA processing in the nucleolus and cytosol 55722 CEP72 False True Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;AURKA Activation by TPX2 55737 VPS35 False True WNT ligand biogenesis and trafficking 55739 CARKD False True Nicotinamide salvaging 55746 NUP133 False True ISG15 antiviral mechanism;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Rev-mediated nuclear export of HIV RNA;Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Viral Messenger RNA Synthesis;NEP/NS2 Interacts with the Cellular Export Machinery;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;snRNP Assembly;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;SUMOylation of DNA damage response and repair proteins;SUMOylation of ubiquitinylation proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;SUMOylation of SUMOylation proteins;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins;Transcriptional regulation by small RNAs;RHO GTPases Activate Formins;tRNA processing in the nucleus;Mitotic Prometaphase 55748 CNDP2 False True Glutathione synthesis and recycling 55758 RCOR3 False True NA 55778 ZNF839 False True Generic Transcription Pathway 55787 TXLNG False True NA 55791 LRIF1 False True NA 55812 SPATA7 False True NA 55814 BDP1 False True RNA Polymerase III Abortive And Retractive Initiation;RNA Polymerase III Transcription Initiation From Type 1 Promoter;RNA Polymerase III Transcription Initiation From Type 1 Promoter;RNA Polymerase III Transcription Initiation From Type 2 Promoter;RNA Polymerase III Transcription Initiation From Type 2 Promoter;RNA Polymerase III Transcription Initiation From Type 3 Promoter;RNA Polymerase III Transcription Initiation From Type 3 Promoter 55815 TSNAXIP1 False True NA 55835 CENPJ False True Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain;AURKA Activation by TPX2 55845 BRK1 False True Regulation of actin dynamics for phagocytic cup formation;Regulation of actin dynamics for phagocytic cup formation;VEGFA-VEGFR2 Pathway;RHO GTPases Activate WASPs and WAVEs;RHO GTPases Activate WASPs and WAVEs 55846 ITFG2 False True NA 55848 PLGRKT False True NA 55850 USE1 False True COPI-dependent Golgi-to-ER retrograde traffic 55861 DBNDD2 False True NA 55884 WSB2 False True Neddylation 55898 UNC45A False True NA 55905 RNF114 False True Antigen processing: Ubiquitination & Proteasome degradation 55916 NXT2 False True NA 55929 DMAP1 False True HATs acetylate histones 55930 MYO5C False True NA 55968 NSFL1C False True NA 55970 GNG12 False True Activation of G protein gated Potassium channels;Glucagon signaling in metabolic regulation;G-protein activation;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;ADP signalling through P2Y purinoceptor 12;G beta:gamma signalling through PI3Kgamma;Prostacyclin signalling through prostacyclin receptor;Prostacyclin signalling through prostacyclin receptor;Adrenaline,noradrenaline inhibits insulin secretion;Adrenaline,noradrenaline inhibits insulin secretion;Ca2+ pathway;Ca2+ pathway;G alpha (q) signalling events;G alpha (12/13) signalling events;G beta:gamma signalling through PLC beta;G alpha (s) signalling events;ADP signalling through P2Y purinoceptor 1;ADP signalling through P2Y purinoceptor 1;G alpha (i) signalling events;G alpha (z) signalling events;Glucagon-type ligand receptors;Thromboxane signalling through TP receptor;Vasopressin regulates renal water homeostasis via Aquaporins;Thrombin signalling through proteinase activated receptors (PARs);Thrombin signalling through proteinase activated receptors (PARs);Presynaptic function of Kainate receptors;Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding;G beta:gamma signalling through BTK;G beta:gamma signalling through CDC42;Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 55975 KLHL7 False True NA 56061 UBFD1 False True NA 56063 TMEM234 False True NA 56243 KIAA1217 False True NA 56259 CTNNBL1 False True mRNA Splicing - Major Pathway 56288 PARD3 False True TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);Tight junction interactions 56300 NA True False Interleukin-36 pathway 56311 NA False True NA 56338 Txnip False True NA 56339 METTL3 False True Processing of Capped Intron-Containing Pre-mRNA 56424 Stub1 False True NA 56475 RPRM False True NA 56477 CCL28 False True Chemokine receptors bind chemokines;G alpha (i) signalling events 56647 BCCIP False True NA 56648 EIF5A2 False True Hypusine synthesis from eIF5A-lysine 56649 TMPRSS4 False True NA 56650 CLDND1 False True NA 56658 TRIM39 False True Antigen processing: Ubiquitination & Proteasome degradation 56659 NA False True Tandem pore domain halothane-inhibited K+ channel (THIK);Phase 4 - resting membrane potential 56667 NA False True Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC);Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS);Defective GALNT12 causes colorectal cancer 1 (CRCS1);Dectin-2 family;O-linked glycosylation of mucins;Termination of O-glycan biosynthesis 56850 GRIPAP1 False True NA 56882 CDC42SE1 False True NA 56888 KCMF1 False True Neutrophil degranulation 56893 UBQLN4 False True NA 56896 DPYSL5 False True CRMPs in Sema3A signaling 56902 PNO1 False True rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol 56904 SH3GLB2 False True NA 56907 NA False True NA 56915 EXOSC5 False True ATF4 activates genes;mRNA decay by 3' to 5' exoribonuclease;Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA;Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA;KSRP (KHSRP) binds and destabilizes mRNA;Major pathway of rRNA processing in the nucleolus and cytosol 56924 PAK6 False True Activation of RAC1 56925 LXN False True NA 56927 NA False True NA 56931 DUS3L False True NA 56935 SMCO4 False True NA 56954 NIT2 False True Neutrophil degranulation 56984 PSMG2 False True NA 56987 BBX False True NA 56998 CTNNBIP1 False True Deactivation of the beta-catenin transactivating complex 57003 CCDC47 False True NA 57016 AKR1B10 False True Retinoid metabolism and transport 57062 DDX24 False True NA 57082 CASC5 False True Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Deposition of new CENPA-containing nucleosomes at the centromere;Mitotic Prometaphase 57085 AGTRAP False True Signaling by BRAF and RAF fusions 57092 PCNP False True NA 57093 TRIM49 False True NA 57107 PDSS2 False True Ubiquinol biosynthesis 57142 RTN4 False True Axonal growth inhibition (RHOA activation) 57157 NA False True NA 57159 TRIM54 False True NA 57165 NA False True Gap junction assembly 57168 NA False True NA 57169 ZNFX1 False True NA 57172 CAMK1G False True NA 57175 CORO1B False True NA 57185 NIPAL3 False True Miscellaneous transport and binding events 57228 NA False True NA 57402 S100A14 True True NA 57418 WDR18 False True Major pathway of rRNA processing in the nucleolus and cytosol 57462 KIAA1161 False True NA 57472 CNOT6 False True Deadenylation of mRNA;Activation of anterior HOX genes in hindbrain development during early embryogenesis;TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 57474 ZNF490 False True Generic Transcription Pathway 57479 PRR12 False True NA 57506 MAVS False True DDX58/IFIH1-mediated induction of interferon-alpha/beta;Ovarian tumor domain proteases;TRAF3-dependent IRF activation pathway;TRAF6 mediated IRF7 activation;TRAF6 mediated NF-kB activation;TRAF6 mediated NF-kB activation;NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10;Negative regulators of DDX58/IFIH1 signaling;Negative regulators of DDX58/IFIH1 signaling 57507 NA False True NA 57510 XPO5 False True MicroRNA (miRNA) biogenesis 57521 RPTOR False True Macroautophagy;mTOR signalling;mTORC1-mediated signalling;HSF1-dependent transactivation;Energy dependent regulation of mTOR by LKB1-AMPK;TP53 Regulates Metabolic Genes;Regulation of PTEN gene transcription 57528 NA False True NA 57530 CGN False True TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition);TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 57542 KLHL42 False True Neddylation;Antigen processing: Ubiquitination & Proteasome degradation 57544 TXNDC16 False True NA 57552 NCEH1 False True LDL clearance 57553 NA False True NA 57562 NA False True NA 57563 KLHL8 False True NA 57565 KLHL14 False True NA 57584 NA False True Rho GTPase cycle 57599 WDR48 False True Recognition of DNA damage by PCNA-containing replication complex;Ub-specific processing proteases;Fanconi Anemia Pathway 57600 FNIP2 False True NA 57617 VPS18 False True NA 57619 NA False True NA 57623 NA False True NA 57626 KLHL1 False True NA 57645 POGK False True NA 57658 CALCOCO1 False True NA 57670 KIAA1549 False True Signaling by BRAF and RAF fusions 57680 CHD8 False True Deactivation of the beta-catenin transactivating complex 57707 TLDC1 False True NA 57718 PPP4R4 False True NA 57722 NA False True NA 57794 SUGP1 False True mRNA Splicing - Major Pathway 57798 GATAD1 False True NA 57805 CCAR2 False True Regulation of HSF1-mediated heat shock response 57819 LSM2 False True mRNA decay by 5' to 3' exoribonuclease;mRNA decay by 5' to 3' exoribonuclease;mRNA Splicing - Major Pathway;mRNA Splicing - Minor Pathway 57820 CCNB1IP1 False True NA 58191 CXCL16 False True Chemokine receptors bind chemokines;G alpha (i) signalling events 58477 SRPRB False True SRP-dependent cotranslational protein targeting to membrane;XBP1(S) activates chaperone genes 58484 NLRC4 False True TP53 Regulates Transcription of Caspase Activators and Caspases;The IPAF inflammasome;The IPAF inflammasome 58490 RPRD1B False True RNA polymerase II transcribes snRNA genes;RNA polymerase II transcribes snRNA genes 58506 NA False True NA 58515 SELK False True NA 58517 RBM25 False True NA 58524 DMRT3 False True NA 58529 MYOZ1 False True NA 59277 NA False True Non-integrin membrane-ECM interactions;Netrin-1 signaling 59286 UBL5 False True NA 59343 SENP2 False True SUMO is proteolytically processed 60312 AFAP1 False True NA 60314 C12orf10 False True NA 60485 SAV1 False True Signaling by Hippo 60491 NIF3L1 False True NA 60492 CCDC90B False True NA 60496 AASDHPPT False True Vitamin B5 (pantothenate) metabolism 60528 ELAC2 False True tRNA processing in the nucleus;tRNA processing in the mitochondrion;rRNA processing in the mitochondrion 60558 NA False True NA 60684 TRAPPC11 False True RAB GEFs exchange GTP for GDP on RABs 63027 SLC22A23 False True NA 63892 THADA False True tRNA modification in the nucleus and cytosol 63893 UBE2O False True Antigen processing: Ubiquitination & Proteasome degradation 63925 ZNF335 False True Activation of anterior HOX genes in hindbrain development during early embryogenesis 63932 CXorf56 False True NA 63943 FKBPL False True The role of GTSE1 in G2/M progression after G2 checkpoint 63951 DMRTA1 False True NA 63982 NA False True Stimuli-sensing channels 64062 RBM26 False True NA 64065 NA True False TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain;Formation of the cornified envelope 64087 MCCC2 False True Biotin transport and metabolism;Defective HLCS causes multiple carboxylase deficiency;Branched-chain amino acid catabolism 64092 SAMSN1 False True NA 64102 TNMD False True NA 64105 CENPK False True Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Deposition of new CENPA-containing nucleosomes at the centromere;Mitotic Prometaphase 64129 TINAGL1 False True NA 64184 EDDM3B False True NA 64215 DNAJC1 False True NA 64320 RNF25 False True Antigen processing: Ubiquitination & Proteasome degradation 64326 RFWD2 False True Autodegradation of the E3 ubiquitin ligase COP1;Neddylation 64327 NA False True NA 64344 HIF3A False True Regulation of gene expression by Hypoxia-inducible Factor;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Transcriptional regulation of pluripotent stem cells;Neddylation 64374 SIL1 False True NA 64407 RGS18 False True G alpha (q) signalling events;G alpha (i) signalling events;G alpha (i) signalling events 64410 NA False True Neddylation;Antigen processing: Ubiquitination & Proteasome degradation 64412 GZF1 False True NA 64417 C5orf28 False True NA 64423 NA False True NA 64428 NARFL False True Cytosolic iron-sulfur cluster assembly 64648 NA False True NA 64663 NA False True NA 64708 COPS7B False True DNA Damage Recognition in GG-NER;Formation of TC-NER Pre-Incision Complex;Cargo recognition for clathrin-mediated endocytosis;Neddylation 64714 PDIA2 False True NA 64745 METTL17 False True NA 64750 SMURF2 False True Signaling by BMP;Downregulation of TGF-beta receptor signaling;Downregulation of TGF-beta receptor signaling;Downregulation of SMAD2/3:SMAD4 transcriptional activity;Downregulation of SMAD2/3:SMAD4 transcriptional activity;Asymmetric localization of PCP proteins;Degradation of AXIN;Hedgehog 'on' state;Hedgehog 'on' state;Ub-specific processing proteases;Regulation of RUNX3 expression and activity;Antigen processing: Ubiquitination & Proteasome degradation 64754 SMYD3 False True PKMTs methylate histone lysines 64755 C16orf58 False True NA 64759 TNS3 False True MET interacts with TNS proteins 64763 ZNF574 False True NA 64771 C6orf106 False True NA 64784 CRTC3 False True Transcriptional activation of mitochondrial biogenesis;Circadian Clock 64785 GINS3 False True Unwinding of DNA;Unwinding of DNA 64837 KLC2 False True MHC class II antigen presentation;RHO GTPases activate KTN1;COPI-dependent Golgi-to-ER retrograde traffic;Kinesins 64848 NA False True NA 64849 NA False True Sodium-coupled sulphate, di- and tri-carboxylate transporters 64866 CDCP1 False True NA 64926 NA False True Regulation of RAS by GAPs;Signaling by RAS mutants 64965 MRPS9 False True Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation elongation;Mitochondrial translation termination 64969 MRPS5 False True Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation elongation;Mitochondrial translation termination 64976 MRPL40 False True Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation elongation;Mitochondrial translation termination 64979 MRPL36 False True Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation elongation;Mitochondrial translation termination 65018 PINK1 False True Pink/Parkin Mediated Mitophagy;FOXO-mediated transcription of cell death genes 65055 REEP1 False True Olfactory Signaling Pathway 65061 CDK15 False True NA 65095 KRI1 False True NA 65108 MARCKSL1 False True NA 65125 WNK1 False True Stimuli-sensing channels 65220 NADK False True Nicotinate metabolism 65263 PYCRL False True Amino acid synthesis and interconversion (transamination) 65265 C8orf33 False True NA 65266 WNK4 False True Stimuli-sensing channels 65268 WNK2 False True Stimuli-sensing channels 65977 NA False True Synthesis of PIPs at the plasma membrane 65982 ZSCAN18 False True NA 71766 NA False True NA 79001 VKORC1 False True Metabolism of vitamin K 79003 MIS12 False True Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase 79012 CAMKV False True NA 79017 GGCT True True Glutathione synthesis and recycling 79026 AHNAK False True NA 79031 PDCL3 False True NA 79039 DDX54 False True NA 79047 KCTD15 False True Negative regulation of activity of TFAP2 (AP-2) family transcription factors 79050 NOC4L False True rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol 79053 ALG8 False True Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein;Defective ALG8 causes ALG8-CDG (CDG-1h) 79058 ASPSCR1 False True Translocation of SLC2A4 (GLUT4) to the plasma membrane 79073 TMEM109 False True NA 79109 MAPKAP1 False True PIP3 activates AKT signaling;CD28 dependent PI3K/Akt signaling;VEGFR2 mediated vascular permeability;Constitutive Signaling by AKT1 E17K in Cancer;Regulation of TP53 Degradation 79139 DERL1 False True ABC-family proteins mediated transport;N-glycan trimming in the ER and Calnexin/Calreticulin cycle;Defective CFTR causes cystic fibrosis;E3 ubiquitin ligases ubiquitinate target proteins 79152 NA False True Sphingolipid de novo biosynthesis 79161 NA False True NA 79171 RBM42 False True NA 79173 C19orf57 False True NA 79176 FBXL15 False True Neddylation;Antigen processing: Ubiquitination & Proteasome degradation 79177 ZNF576 False True NA 79180 EFHD2 False True NA 79183 NA False True NA 79188 TMEM43 False True NA 79228 THOC6 False True Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA 3'-end processing 79366 NA False True NA 79415 C17orf62 False True NA 79587 CARS2 False True Mitochondrial tRNA aminoacylation 79598 CEP97 False True Anchoring of the basal body to the plasma membrane 79622 SNRNP25 False True mRNA Splicing - Minor Pathway 79624 C6orf211 False True NA 79633 NA False True NA 79647 NA False True NA 79654 HECTD3 False True Antigen processing: Ubiquitination & Proteasome degradation 79657 RPAP3 False True NA 79666 PLEKHF2 False True NA 79669 C3orf52 False True NA 79691 QTRTD1 False True tRNA modification in the nucleus and cytosol 79696 ZC2HC1C False True NA 79710 MORC4 False True NA 79711 IPO4 False True NA 79717 PPCS False True Coenzyme A biosynthesis 79718 TBL1XR1 False True RORA activates gene expression;BMAL1:CLOCK,NPAS2 activates circadian gene expression;PPARA activates gene expression;PPARA activates gene expression;NOTCH1 Intracellular Domain Regulates Transcription;Transcriptional activation of mitochondrial biogenesis;Activation of gene expression by SREBF (SREBP);Constitutive Signaling by NOTCH1 PEST Domain Mutants;Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;HDACs deacetylate histones;Transcriptional regulation of white adipocyte differentiation;Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha);Circadian Clock;Loss of MECP2 binding ability to the NCoR/SMRT complex;Regulation of MECP2 expression and activity 79724 NA False True NA 79726 WDR59 False True NA 79728 PALB2 False True HDR through Homologous Recombination (HRR);Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA);Resolution of D-loop Structures through Holliday Junction Intermediates;Homologous DNA Pairing and Strand Exchange 79763 ISOC2 False True NA 79770 TXNDC15 False True NA 79786 KLHL36 False True NA 79798 NA False True NA 79801 SHCBP1 False True NA 79809 NA False True Hedgehog 'off' state;Intraflagellar transport 79811 SLTM False True NA 79822 NA False True NA 79830 NA False True NA 79831 KDM8 False True HDMs demethylate histones 79839 CCDC102B False True NA 79853 TM4SF20 False True NA 79858 NEK11 False True NA 79861 TUBAL3 False True Translocation of SLC2A4 (GLUT4) to the plasma membrane;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;Gap junction assembly;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HSP90 chaperone cycle for steroid hormone receptors (SHR);Recruitment of NuMA to mitotic centrosomes;Formation of tubulin folding intermediates by CCT/TriC;Post-chaperonin tubulin folding pathway;Recycling pathway of L1;Recycling pathway of L1;Cilium Assembly;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;Carboxyterminal post-translational modifications of tubulin;Carboxyterminal post-translational modifications of tubulin;Activation of AMPK downstream of NMDARs;Kinesins 79869 CPSF7 False True Cleavage of Growing Transcript in the Termination Region ;mRNA Splicing - Major Pathway;mRNA 3'-end processing;Processing of Intronless Pre-mRNAs 79873 NUDT18 False True Phosphate bond hydrolysis by NUDT proteins 79887 PLBD1 True True Acyl chain remodelling of PC;Acyl chain remodelling of PE;Acyl chain remodelling of PI;Hydrolysis of LPC 79901 CYBRD1 False True Iron uptake and transport 79930 DOK3 False True Neutrophil degranulation 79932 NA False True NA 79947 DHDDS False True Synthesis of Dolichyl-phosphate;Defective DHDDS causes retinitis pigmentosa 59 79968 WDR76 False True NA 79980 DSN1 False True Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Neutrophil degranulation;Mitotic Prometaphase 79983 POF1B True True NA 80007 C10orf88 False True NA 80011 FAM192A False True NA 80012 PHC3 False True Oxidative Stress Induced Senescence;SUMOylation of DNA damage response and repair proteins;SUMOylation of transcription cofactors;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA methylation proteins;RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known;Regulation of PTEN gene transcription;Regulation of PTEN gene transcription;Transcriptional Regulation by E2F6 80017 C14orf159 False True NA 80028 FBXL18 False True NA 80086 TUBA4B False True NA 80139 NA False True Generic Transcription Pathway 80145 THOC7 False True Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA 3'-end processing 80153 EDC3 False True mRNA decay by 5' to 3' exoribonuclease 80154 GOLGA2P10 False True NA 80176 SPSB1 False True Neddylation;Antigen processing: Ubiquitination & Proteasome degradation 80179 MYO19 False True NA 80185 TTI2 False True NA 80196 RNF34 False True Regulation of TP53 Degradation;Antigen processing: Ubiquitination & Proteasome degradation 80207 OPA3 False True NA 80216 ALPK1 False True NA 80217 NA False True NA 80218 NAA50 False True NA 80223 RAB11FIP1 False True NA 80273 GRPEL1 False True Mitochondrial protein import 80279 CDK5RAP3 False True NA 80301 PLEKHO2 False True Neutrophil degranulation 80311 KLHL15 False True NA 80314 EPC1 False True HATs acetylate histones;Transcriptional Regulation by E2F6 80318 GKAP1 False True NA 80332 ADAM33 False True NA 80349 WDR61 False True Formation of RNA Pol II elongation complex ;mRNA decay by 3' to 5' exoribonuclease;RNA Polymerase II Pre-transcription Events;RNA Polymerase II Transcription Elongation;E3 ubiquitin ligases ubiquitinate target proteins 80705 TSGA10 False True NA 80726 KIAA1683 False True NA 80742 PRR3 False True NA 80775 TMEM177 False True NA 80777 CYB5B False True Phase I - Functionalization of compounds 80817 CEP44 False True NA 80856 KIAA1715 False True NA 81027 TUBB1 False True Translocation of SLC2A4 (GLUT4) to the plasma membrane;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;Gap junction assembly;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HSP90 chaperone cycle for steroid hormone receptors (SHR);Recruitment of NuMA to mitotic centrosomes;Prefoldin mediated transfer of substrate to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Post-chaperonin tubulin folding pathway;Recycling pathway of L1;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;Carboxyterminal post-translational modifications of tubulin;Carboxyterminal post-translational modifications of tubulin;Activation of AMPK downstream of NMDARs;Kinesins 81494 CFHR5 False True Regulation of Complement cascade 81544 GDPD5 False True Glycerophospholipid catabolism 81545 FBXO38 False True NA 81556 VWA9 False True RNA polymerase II transcribes snRNA genes;RNA polymerase II transcribes snRNA genes 81565 NDEL1 False True Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase 81567 TXNDC5 False True Lysosome Vesicle Biogenesis;Golgi Associated Vesicle Biogenesis;Neutrophil degranulation 81572 PDRG1 False True NA 81576 CCDC130 False True NA 81605 URM1 False True tRNA modification in the nucleus and cytosol 81611 ANP32E False True NA 81624 DIAPH3 False True RHO GTPases Activate Formins 81629 TSSK3 False True NA 81671 NA False True NA 81786 TRIM7 False True NA 81788 NUAK2 False True NA 81790 RNF170 False True NA 81810 NA False True NA 81844 TRIM56 False True Regulation of innate immune responses to cytosolic DNA 81853 TMEM14B False True NA 81873 ARPC5L False True NA 81875 NA False True Major pathway of rRNA processing in the nucleolus and cytosol 81889 FAHD1 False True Citric acid cycle (TCA cycle) 81929 SEH1L False True ISG15 antiviral mechanism;Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Transport of the SLBP independent Mature mRNA;Transport of the SLBP Dependant Mature mRNA;Transport of Mature mRNA Derived from an Intronless Transcript;Transport of Mature mRNA derived from an Intron-Containing Transcript;Rev-mediated nuclear export of HIV RNA;Transport of Ribonucleoproteins into the Host Nucleus;NS1 Mediated Effects on Host Pathways;Viral Messenger RNA Synthesis;NEP/NS2 Interacts with the Cellular Export Machinery;Regulation of Glucokinase by Glucokinase Regulatory Protein;Nuclear import of Rev protein;Vpr-mediated nuclear import of PICs;snRNP Assembly;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;SUMOylation of DNA damage response and repair proteins;SUMOylation of ubiquitinylation proteins;Nuclear Pore Complex (NPC) Disassembly;Regulation of HSF1-mediated heat shock response;SUMOylation of SUMOylation proteins;SUMOylation of chromatin organization proteins;SUMOylation of RNA binding proteins;SUMOylation of DNA replication proteins;SUMOylation of DNA replication proteins;Transcriptional regulation by small RNAs;RHO GTPases Activate Formins;tRNA processing in the nucleus;Mitotic Prometaphase 83446 CCDC70 False True NA 83481 EPPK1 True True NA 83540 NUF2 False True Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase 83541 FAM110A False True NA 83594 NUDT12 False True Nicotinamide salvaging 83640 FAM103A1 False True NA 83659 NA False True NA 83660 TLN2 False True NA 83692 CD99L2 False True Cell surface interactions at the vascular wall 83693 NA False True NA 83694 NA False True NA 83699 SH3BGRL2 False True NA 83719 YPEL3 False True NA 83737 ITCH False True Downregulation of ERBB4 signaling;NOD1/2 Signaling Pathway;Activated NOTCH1 Transmits Signal to the Nucleus;Activated NOTCH1 Transmits Signal to the Nucleus;Degradation of GLI1 by the proteasome;Hedgehog 'on' state;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Negative regulators of DDX58/IFIH1 signaling;Antigen processing: Ubiquitination & Proteasome degradation 83742 NA False True NA 83861 RSPH3 False True NA 83871 RAB34 False True RAB geranylgeranylation 83878 USHBP1 False True NA 83939 EIF2A False True NA 83942 TSSK1B False True NA 83983 TSSK6 False True NA 83990 BRIP1 False True Cytosolic iron-sulfur cluster assembly;HDR through Single Strand Annealing (SSA);HDR through Homologous Recombination (HRR);Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA);Resolution of D-loop Structures through Holliday Junction Intermediates;Homologous DNA Pairing and Strand Exchange;Processing of DNA double-strand break ends;Presynaptic phase of homologous DNA pairing and strand exchange;Regulation of TP53 Activity through Phosphorylation;G2/M DNA damage checkpoint 84059 NA False True NA 84060 RBM48 False True NA 84063 KIRREL2 False True Nephrin family interactions 84065 NA False True NA 84074 NA False True NA 84076 TKTL2 False True NA 84078 KBTBD7 False True Regulation of RAS by GAPs;Neddylation;Antigen processing: Ubiquitination & Proteasome degradation 84080 ENKD1 False True NA 84102 SLC41A2 False True Metal ion SLC transporters 84108 PCGF6 False True Transcriptional Regulation by E2F6 84128 NA False True rRNA modification in the nucleus and cytosol;Major pathway of rRNA processing in the nucleolus and cytosol 84131 CEP78 False True Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;AURKA Activation by TPX2 84133 ZNRF3 False True Regulation of FZD by ubiquitination 84134 TOMM40L False True NA 84140 FAM161A False True NA 84148 KAT8 False True HATs acetylate histones 84154 RPF2 False True NA 84163 NA False True NA 84164 ASCC2 False True ALKBH3 mediated reversal of alkylation damage 84168 ANTXR1 False True Uptake and function of anthrax toxins 84174 SLA2 False True NA 84218 NA False True NA 84219 WDR24 False True NA 84254 CAMKK1 False True CaMK IV-mediated phosphorylation of CREB;CaMK IV-mediated phosphorylation of CREB;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;Activation of RAC1 downstream of NMDARs;Activation of RAC1 downstream of NMDARs 84259 DCUN1D5 False True Neddylation 84260 TCHP False True NA 84262 PSMG3 False True NA 84273 NA False True NA 84277 DNAJC30 False True NA 84290 CAPNS2 False True Degradation of the extracellular matrix;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models 84292 WDR83 False True MAP2K and MAPK activation 84294 UTP23 False True NA 84300 UQCC2 False True NA 84301 DDI2 False True NA 84314 TMEM107 False True NA 84320 ACBD6 False True Mitochondrial Fatty Acid Beta-Oxidation 84324 SARNP False True Cleavage of Growing Transcript in the Termination Region ;Transport of Mature mRNA derived from an Intron-Containing Transcript;mRNA 3'-end processing 84333 PCGF5 False True RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 84445 LZTS2 False True NA 84447 SYVN1 False True XBP1(S) activates chaperone genes;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;ER Quality Control Compartment (ERQC) 84457 PHYHIPL False True NA 84501 NA False True NA 84522 JAGN1 False True NA 84525 HOPX False True NA 84614 NA False True NA 84617 TUBB6 False True Translocation of SLC2A4 (GLUT4) to the plasma membrane;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;Gap junction assembly;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HSP90 chaperone cycle for steroid hormone receptors (SHR);Recruitment of NuMA to mitotic centrosomes;Prefoldin mediated transfer of substrate to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Post-chaperonin tubulin folding pathway;Recycling pathway of L1;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;Carboxyterminal post-translational modifications of tubulin;Carboxyterminal post-translational modifications of tubulin;Activation of AMPK downstream of NMDARs;Kinesins 84619 ZGPAT False True NA 84687 PPP1R9B False True NA 84707 BEX2 False True NA 84708 LNX1 False True Antigen processing: Ubiquitination & Proteasome degradation 84717 HDGFRP2 False True NA 84759 PCGF1 False True NA 84790 TUBA1C False True Translocation of SLC2A4 (GLUT4) to the plasma membrane;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;Gap junction assembly;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HSP90 chaperone cycle for steroid hormone receptors (SHR);Recruitment of NuMA to mitotic centrosomes;Prefoldin mediated transfer of substrate to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Post-chaperonin tubulin folding pathway;Recycling pathway of L1;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;Carboxyterminal post-translational modifications of tubulin;Carboxyterminal post-translational modifications of tubulin;Activation of AMPK downstream of NMDARs;Kinesins 84808 NA False True Transcriptional activation of mitochondrial biogenesis 84823 LMNB2 False True NA 84832 ANKRD36BP1 False True NA 84833 NA False True NA 84861 KLHL22 False True Neddylation;Antigen processing: Ubiquitination & Proteasome degradation 84873 GPR128 False True NA 84886 NA False True NA 84893 FBXO18 False True NA 84902 CEP89 False True Anchoring of the basal body to the plasma membrane 84912 SLC35B4 False True Transport of nucleotide sugars 84926 NA False True NA 84930 MASTL False True MASTL Facilitates Mitotic Progression;MASTL Facilitates Mitotic Progression 84936 ZFYVE19 False True NA 84939 MUM1 False True NA 84946 LTV1 False True Major pathway of rRNA processing in the nucleolus and cytosol 84951 TNS4 False True MET interacts with TNS proteins 84952 CGNL1 False True NA 84962 AJUBA False True Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Regulation of PLK1 Activity at G2/M Transition;Activation of anterior HOX genes in hindbrain development during early embryogenesis 84966 NA False True NA 84975 MFSD5 False True NA 84987 COX14 False True TP53 Regulates Metabolic Genes;Respiratory electron transport 84993 UBL7 False True NA 84996 URB1-AS1 False True NA 85013 TMEM128 False True NA 85025 NA False True NA 85302 FBF1 False True Anchoring of the basal body to the plasma membrane 85359 DGCR6L False True NA 85366 MYLK2 False True NA 85369 STRIP1 False True NA 85395 NA False True NA 85415 RHPN2 False True RHO GTPases Activate Rhotekin and Rhophilins;RHO GTPases Activate Rhotekin and Rhophilins 85437 ZCRB1 False True mRNA Splicing - Minor Pathway 85439 STON2 False True Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis 85440 DOCK7 False True MET activates RAP1 and RAC1;Factors involved in megakaryocyte development and platelet production 85451 UNK False True NA 85458 DIXDC1 False True NA 85459 CEP295 False True NA 85464 SSH2 False True NA 85481 PSKH2 False True NA 87178 PNPT1 False True NA 89122 TRIM4 False True Antigen processing: Ubiquitination & Proteasome degradation 89777 NA True False Neutrophil degranulation 89857 KLHL6 False True NA 89872 NA False True Passive transport by Aquaporins 89885 FATE1 False True NA 89941 RHOT2 False True Rho GTPase cycle 89953 KLC4 False True MHC class II antigen presentation;RHO GTPases activate KTN1;COPI-dependent Golgi-to-ER retrograde traffic;Kinesins 90060 CCDC120 False True NA 90161 NA False True HS-GAG biosynthesis 90293 KLHL13 False True Neddylation;Antigen processing: Ubiquitination & Proteasome degradation 90379 DCAF15 False True NA 90407 TMEM41A False True NA 90410 IFT20 False True Intraflagellar transport;Intraflagellar transport 90411 MCFD2 False True COPII-mediated vesicle transport;Cargo concentration in the ER;Transport to the Golgi and subsequent modification 90416 NA False True NA 90417 KNSTRN False True NA 90488 NA False True NA 90523 MLIP False True NA 90594 ZNF439 False True Generic Transcription Pathway 90678 LRSAM1 False True Antigen processing: Ubiquitination & Proteasome degradation 90799 CEP95 False True NA 90861 HN1L False True NA 90864 NA False True Neddylation 90871 TMEM261 False True NA 90933 TRIM41 False True Antigen processing: Ubiquitination & Proteasome degradation 90957 DHX57 False True NA 91147 TMEM67 False True Anchoring of the basal body to the plasma membrane 91272 BOD1 False True NA 91319 DERL3 False True ABC-family proteins mediated transport;Defective CFTR causes cystic fibrosis 91369 ANKRD40 False True NA 91464 NA False True NA 91607 NA False True NA 91612 CHURC1 False True NA 91624 NEXN False True NA 91647 ATPAF2 False True NA 91662 NLRP12 False True NA 91663 MYADM False True NA 91683 SYT12 False True Neurexins and neuroligins 91694 LONRF1 False True Antigen processing: Ubiquitination & Proteasome degradation 91748 ELMSAN1 False True NA 91754 NEK9 False True Activation of NIMA Kinases NEK9, NEK6, NEK7;Nuclear Pore Complex (NPC) Disassembly 91768 NA False True Cyclin E associated events during G1/S transition ;Cyclin A:Cdk2-associated events at S phase entry;Factors involved in megakaryocyte development and platelet production 91807 MYLK3 False True NA 91833 WDR20 False True Ub-specific processing proteases 91869 RFT1 False True Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein;Defective RFT1 causes RFT1-CDG (CDG-1n) 92070 NA False True NA 92092 ZC3HAV1L False True NA 92140 MTDH False True NA 92345 NAF1 False True NA 92346 C1orf105 False True NA 92359 CRB3 False True Tight junction interactions 92399 MRRF False True Mitochondrial translation termination 92483 LDHAL6B False True Pyruvate metabolism 92521 SPECC1 False True NA 92558 NA False True NA 92597 MOB1B False True Signaling by Hippo 92749 NA False True NA 92840 REEP6 False True Olfactory Signaling Pathway 92906 HNRNPLL False True NA 92922 NA False True NA 92935 MARS2 False True Mitochondrial tRNA aminoacylation 92979 MARCH9 False True NA 93100 NAPRT False True Nicotinamide salvaging;Neutrophil degranulation 93323 HAUS8 False True Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;AURKA Activation by TPX2 93426 SYCE1 False True Meiotic synapsis 93986 FOXP2 False True NA 94005 PIGS False True Attachment of GPI anchor to uPAR 94081 SFXN1 False True NA 94101 ORMDL1 False True Sphingolipid de novo biosynthesis 94103 ORMDL3 False True Sphingolipid de novo biosynthesis;Neutrophil degranulation 94107 NA False True NA 96459 FNIP1 False True NA 103910 MYL12B False True EPHA-mediated growth cone collapse;Sema4D induced cell migration and growth-cone collapse;Smooth Muscle Contraction;RHO GTPases activate PKNs;RHO GTPases activate CIT;RHO GTPases Activate ROCKs;RHO GTPases activate PAKs;RHO GTPases activate PAKs 112399 EGLN3 False True Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 112616 NA False True NA 112714 TUBA3E False True Translocation of SLC2A4 (GLUT4) to the plasma membrane;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;Gap junction assembly;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HSP90 chaperone cycle for steroid hormone receptors (SHR);Recruitment of NuMA to mitotic centrosomes;Formation of tubulin folding intermediates by CCT/TriC;Post-chaperonin tubulin folding pathway;Recycling pathway of L1;Recycling pathway of L1;Cilium Assembly;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;Carboxyterminal post-translational modifications of tubulin;Carboxyterminal post-translational modifications of tubulin;Activation of AMPK downstream of NMDARs;Kinesins 112770 C1orf85 False True NA 112802 KRT71 False True Keratinization;Formation of the cornified envelope 112858 TP53RK False True tRNA modification in the nucleus and cytosol;Regulation of TP53 Activity through Phosphorylation 112869 CCDC101 False True HATs acetylate histones 112936 VPS26B False True NA 112950 MED8 False True PPARA activates gene expression;Generic Transcription Pathway;Transcriptional regulation of white adipocyte differentiation;Transcriptional regulation of white adipocyte differentiation 113146 AHNAK2 False True NA 113220 KIF12 False True COPI-dependent Golgi-to-ER retrograde traffic;Kinesins 113452 TMEM54 False True NA 113829 NA False True NA 113878 DTX2 False True Activated NOTCH1 Transmits Signal to the Nucleus;Activated NOTCH1 Transmits Signal to the Nucleus 114792 KLHL32 False True NA 114818 KLHL29 False True NA 114822 RHPN1 False True RHO GTPases Activate Rhotekin and Rhophilins;RHO GTPases Activate Rhotekin and Rhophilins 114824 PNMA5 False True NA 114882 NA False True Acyl chain remodelling of PS 114883 OSBPL9 False True Synthesis of bile acids and bile salts 114897 NA False True NA 114907 FBXO32 False True Neddylation;FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes;Antigen processing: Ubiquitination & Proteasome degradation 114971 PTPMT1 False True Synthesis of PG 114984 FLYWCH2 False True NA 115106 HAUS1 False True Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;AURKA Activation by TPX2 115207 KCTD12 False True NA 115290 FBXO17 False True Neddylation;Antigen processing: Ubiquitination & Proteasome degradation 115353 LRRC42 False True NA 115548 FCHO2 False True Cargo recognition for clathrin-mediated endocytosis;Clathrin-mediated endocytosis 116039 NA False True NA 116138 KLHDC3 False True XBP1(S) activates chaperone genes 116173 CMTM5 False True NA 116540 MRPL53 False True Mitochondrial translation initiation;Mitochondrial translation elongation;Mitochondrial translation elongation;Mitochondrial translation termination 116988 NA False True NA 117157 SH2D1B False True Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 117159 DCD True True Antimicrobial peptides 117177 RAB3IP False True Anchoring of the basal body to the plasma membrane;VxPx cargo-targeting to cilium;BBSome-mediated cargo-targeting to cilium;RAB GEFs exchange GTP for GDP on RABs 117178 SSX2IP False True NA 117284 Lrrc7 False True NA 117583 PARD3B False True NA 118460 EXOSC6 False True ATF4 activates genes;mRNA decay by 3' to 5' exoribonuclease;Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA;Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA;KSRP (KHSRP) binds and destabilizes mRNA;Major pathway of rRNA processing in the nucleolus and cytosol 119016 NA False True NA 119358 NA False True NA 120892 LRRK2 False True PTK6 promotes HIF1A stabilization 121355 GTSF1 False True NA 121457 IKBIP False True NA 122060 SLAIN1 False True NA 122258 NA False True NA 123169 LEO1 False True Formation of RNA Pol II elongation complex ;Formation of the beta-catenin:TCF transactivating complex;RNA Polymerase II Pre-transcription Events;RNA Polymerase II Transcription Elongation;E3 ubiquitin ligases ubiquitinate target proteins 123811 NA False True NA 123920 CMTM3 False True NA 124220 ZG16B True True NA 124540 MSI2 False True NA 124641 OVCA2 False True NA 124801 LSM12 False True NA 124997 WDR81 False True NA 125058 TBC1D16 False True TBC/RABGAPs 125115 KRT40 False True Keratinization;Formation of the cornified envelope 125488 NA False True NA 125875 NA False True NA 126003 TRAPPC5 False True COPII-mediated vesicle transport;RAB GEFs exchange GTP for GDP on RABs 126070 ZNF440 False True Generic Transcription Pathway 126123 NA False True Sperm:Oocyte Membrane Binding 126298 NA False True NA 126326 NA False True NA 126353 MISP False True NA 126433 FBXO27 False True Neddylation;Antigen processing: Ubiquitination & Proteasome degradation 127247 ASB17 False True Neddylation;Antigen processing: Ubiquitination & Proteasome degradation 127544 RNF19B False True Antigen processing: Ubiquitination & Proteasome degradation 127703 C1orf216 False True NA 128240 APOA1BP False True Nicotinamide salvaging 128653 NA False True NA 128869 PIGU False True Attachment of GPI anchor to uPAR 128989 TANGO2 False True NA 129807 NEU4 False True Glycosphingolipid metabolism;Sialic acid metabolism 129852 NA False True NA 130399 NA False True Signaling by NODAL;Regulation of signaling by NODAL;Signaling by Activin;Signaling by Activin 130872 NA False True NA 131118 DNAJC19 False True Mitochondrial protein import 131616 NA False True NA 131831 ERICH6 False True NA 131890 NA False True Inactivation, recovery and regulation of the phototransduction cascade 132001 TAMM41 False True NA 132158 GLYCTK False True Fructose catabolism 132789 GNPDA2 False True Glycolysis 132864 CPEB2 False True NA 133022 NA False True NA 133746 NA False True Regulation of TP53 Activity through Methylation 134218 DNAJC21 False True NA 135228 NA False True Platelet degranulation ;Post-translational modification: synthesis of GPI-anchored proteins 136319 MTPN False True NA 138716 NA False True NA 139324 NA False True NA 139741 NA False True NA 140459 ASB6 False True Neddylation;Antigen processing: Ubiquitination & Proteasome degradation 140465 MYL6B False True Smooth Muscle Contraction 140467 NA False True NA 140469 NA False True NA 140576 S100A16 False True NA 140691 TRIM69 False True Antigen processing: Ubiquitination & Proteasome degradation 140738 TMEM37 False True NA 140739 UBE2F False True Neddylation;Antigen processing: Ubiquitination & Proteasome degradation 140801 RPL10L False True L13a-mediated translational silencing of Ceruloplasmin expression;Peptide chain elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane;Viral mRNA Translation;Selenocysteine synthesis;Major pathway of rRNA processing in the nucleolus and cytosol;Formation of a pool of free 40S subunits;GTP hydrolysis and joining of the 60S ribosomal subunit;Eukaryotic Translation Termination;Regulation of expression of SLITs and ROBOs;Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 140807 NA False True Keratinization;Formation of the cornified envelope 140823 ROMO1 False True NA 140850 DEFB127 False True Beta defensins;Defensins 140885 SIRPA False True Cell surface interactions at the vascular wall;Signal regulatory protein family interactions;Signal regulatory protein family interactions;Neutrophil degranulation 142684 RAB40A False True RAB geranylgeranylation 143244 EIF5AL1 False True NA 143471 PSMA8 False True Activation of NF-kappaB in B cells;Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;ER-Phagosome pathway;Cross-presentation of soluble exogenous antigens (endosomes);SCF-beta-TrCP mediated degradation of Emi1;APC/C:Cdc20 mediated degradation of Securin;APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Vpu mediated degradation of CD4;Vif-mediated degradation of APOBEC3G;Degradation of beta-catenin by the destruction complex;Downstream TCR signaling;Regulation of activated PAK-2p34 by proteasome mediated degradation;Separation of Sister Chromatids;FCERI mediated NF-kB activation;Autodegradation of the E3 ubiquitin ligase COP1;Regulation of ornithine decarboxylase (ODC);ABC-family proteins mediated transport;AUF1 (hnRNP D0) binds and destabilizes mRNA;Asymmetric localization of PCP proteins;Degradation of AXIN;Degradation of DVL;Hedgehog ligand biogenesis;Hh mutants that don't undergo autocatalytic processing are degraded by ERAD;Dectin-1 mediated noncanonical NF-kB signaling;CLEC7A (Dectin-1) signaling;Degradation of GLI1 by the proteasome;Degradation of GLI2 by the proteasome;GLI3 is processed to GLI3R by the proteasome;Hedgehog 'on' state;Regulation of RAS by GAPs;TNFR2 non-canonical NF-kB pathway;NIK-->noncanonical NF-kB signaling;Defective CFTR causes cystic fibrosis;MAPK6/MAPK4 signaling;UCH proteinases;Ub-specific processing proteases;CDT1 association with the CDC6:ORC:origin complex;Orc1 removal from chromatin;CDK-mediated phosphorylation and removal of Cdc6;Ubiquitin-dependent degradation of Cyclin D1;G2/M Checkpoints;Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;The role of GTSE1 in G2/M progression after G2 checkpoint;FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Regulation of RUNX2 expression and activity;Regulation of PTEN stability and activity;Neddylation;Regulation of expression of SLITs and ROBOs;Interleukin-1 signaling;Antigen processing: Ubiquitination & Proteasome degradation 143630 NA False True NA 143884 CWF19L2 False True NA 144097 C11orf84 False True NA 144110 NA False True NA 144404 TMEM120B False True NA 144406 NA False True NA 144501 NA True False Keratinization;Formation of the cornified envelope 144568 NA True False NA 144699 FBXL14 False True Neddylation;Antigen processing: Ubiquitination & Proteasome degradation 144983 HNRNPA1L2 False True NA 145264 SERPINA12 True True NA 145946 SPATA8 False True NA 147007 TMEM199 False True NA 147687 ZNF417 False True Generic Transcription Pathway 147700 KLC3 False True MHC class II antigen presentation;RHO GTPases activate KTN1;COPI-dependent Golgi-to-ER retrograde traffic;Kinesins 147746 HIPK4 False True NA 147872 CCDC155 False True NA 148266 NA False True Generic Transcription Pathway 148281 SYT6 False True NA 148867 NA False True Insulin processing;Zinc efflux and compartmentalization by the SLC30 family 149111 NA False True COPII-mediated vesicle transport;Cargo concentration in the ER 149371 EXOC8 False True Translocation of SLC2A4 (GLUT4) to the plasma membrane;Insulin processing;VxPx cargo-targeting to cilium 149420 PDIK1L False True NA 149950 NA False True NA 150094 SIK1 False True Circadian Clock 150275 CCDC117 False True NA 150353 NA False True NA 150483 TEKT4 False True NA 150684 COMMD1 False True Neddylation 151011 SEPT10 False True NA 151230 NA False True NA 151246 SGOL2 False True Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Mitotic Prometaphase 151254 ALS2CR11 False True NA 151393 RMDN2 False True NA 152110 NA False True NA 152137 CCDC50 False True NA 152756 NA False True NA 153769 SH3RF2 False True NA 154754 NA False True NA 154796 AMOT False True Signaling by Hippo 155030 gag False True Uncoating of the HIV Virion;Budding and maturation of HIV virion;Integration of provirus;Early Phase of HIV Life Cycle;Minus-strand DNA synthesis;Plus-strand DNA synthesis;2-LTR circle formation;Binding and entry of HIV virion;Membrane binding and targetting of GAG proteins;Synthesis And Processing Of GAG, GAGPOL Polyproteins;Assembly Of The HIV Virion;Integration of viral DNA into host genomic DNA;Autointegration results in viral DNA circles;APOBEC3G mediated resistance to HIV-1 infection;Vpr-mediated nuclear import of PICs 157285 SGK223 False True NA 157378 TMEM65 False True NA 157680 NA False True NA 157753 NA False True NA 158787 RIBC1 False True NA 158866 NA False True NA 159989 CCDC67 False True NA 160140 C11orf65 False True NA 160287 LDHAL6A False True Pyruvate metabolism 160760 PPTC7 False True NA 161142 FAM71D False True NA 164127 CCDC185 False True NA 165721 DNAJB8 False True NA 166614 DCLK2 False True NA 166793 ZBTB49 False True NA 166929 NA False True Sphingolipid de novo biosynthesis 167465 NA False True NA 167838 TXLNB False True NA 168400 DDX53 False True NA 169026 SLC30A8 False True Insulin processing;Zinc efflux and compartmentalization by the SLC30 family 169714 QSOX2 False True NA 170082 TCEANC False True NA 170394 NA False True NA 170954 PPP1R18 False True NA 171024 SYNPO2 False True NA 171483 FAM9B False True NA 196051 PPAPDC1A False True Role of phospholipids in phagocytosis 196374 NA True False Keratinization;Formation of the cornified envelope 196549 NA False True NA 199953 NA False True NA 199990 C1orf86 False True Fanconi Anemia Pathway 200081 TXLNA False True Other interleukin signaling 200205 IBA57 False True NA 201161 CENPV False True NA 201163 FLCN False True NA 201164 NA False True Synthesis of PG;Synthesis of PA;PIWI-interacting RNA (piRNA) biogenesis 201181 ZNF385C False True NA 202459 OSTCP1 False True NA 202559 KHDRBS2 False True PTK6 Regulates Proteins Involved in RNA Processing 203062 TSNARE1 False True NA 203068 TUBB False True Regulation of PLK1 Activity at G2/M Transition;Loss of Nlp from mitotic centrosomes;Recruitment of mitotic centrosome proteins and complexes;Loss of proteins required for interphase microtubule organization from the centrosome;Recruitment of NuMA to mitotic centrosomes;Anchoring of the basal body to the plasma membrane;Neutrophil degranulation;AURKA Activation by TPX2 206338 NA False True NA 219749 NA False True Generic Transcription Pathway 219854 TMEM218 False True NA 219988 PATL1 False True mRNA decay by 5' to 3' exoribonuclease;mRNA decay by 5' to 3' exoribonuclease 220717 RPLP0P6 False True NA 220988 HNRNPA3 False True mRNA Splicing - Major Pathway;Processing of Capped Intron-Containing Pre-mRNA 221092 HNRNPUL2 False True NA 221443 OARD1 False True NA 221927 BRAT1 False True NA 221938 NA False True NA 222229 LRWD1 False True NA 222235 FBXL13 False True Neddylation;Antigen processing: Ubiquitination & Proteasome degradation 222484 LNX2 False True NA 222662 LHFPL5 False True NA 225689 MAPK15 False True NA 253143 NA False True NA 253827 MSRB3 False True Protein repair 253943 YTHDF3 False True NA 254359 NA False True NA 254428 NA False True Metal ion SLC transporters 254879 NA False True Olfactory Signaling Pathway 255189 NA False True Acyl chain remodelling of PC;Acyl chain remodelling of PS;Acyl chain remodelling of PE;Acyl chain remodelling of PI;Acyl chain remodelling of PG;Hydrolysis of LPC 255394 TCP11L2 False True NA 257000 TINCR False True NA 257240 KLHL34 False True NA 259217 NA False True Regulation of HSF1-mediated heat shock response 259232 NALCN False True Stimuli-sensing channels 261726 TIPRL False True NA 282974 STK32C False True NA 283078 MKX False True NA 283160 NA False True Olfactory Signaling Pathway 283165 NA False True NA 283209 PGM2L1 False True Glycogen synthesis;Glycolysis;Glycogen breakdown (glycogenolysis);Galactose catabolism 283237 TTC9C False True NA 283385 MORN3 False True NA 283431 NA False True NA 283455 KSR2 False True MAP2K and MAPK activation;Signaling by moderate kinase activity BRAF mutants;Signaling by high-kinase activity BRAF mutants;Signaling by RAS mutants;Signaling by BRAF and RAF fusions;Paradoxical activation of RAF signaling by kinase inactive BRAF 283458 NA False True NA 283742 FAM98B False True tRNA processing in the nucleus 283870 NA False True NA 284058 KANSL1 False True HATs acetylate histones 284069 NA False True NA 284076 TTLL6 False True Carboxyterminal post-translational modifications of tubulin 284086 NEK8 False True NA 284217 LAMA1 False True Laminin interactions;Laminin interactions;Non-integrin membrane-ECM interactions;ECM proteoglycans;L1CAM interactions;MET activates PTK2 signaling 284276 NA False True NA 284403 WDR62 False True NA 284415 NA False True NA 284418 FAM71E2 False True NA 284618 NA False True NA 285093 NA False True Olfactory Signaling Pathway 285753 CEP57L1 False True NA 286077 FAM83H False True NA 286262 TPRN False True NA 286410 ATP11C False True Ion transport by P-type ATPases 286451 NA False True Golgi Associated Vesicle Biogenesis 286887 NA False True Keratinization;Formation of the cornified envelope 287015 TRIM42 False True NA 317649 EIF4E3 False True ISG15 antiviral mechanism 317719 KLHL10 False True NA 317772 HIST2H2AB False True HDACs deacetylate histones;HATs acetylate histones;HATs acetylate histones;RMTs methylate histone arginines;UCH proteinases;Ub-specific processing proteases;Metalloprotease DUBs 319101 NA False True Keratinization;Formation of the cornified envelope 337879 NA False True Keratinization 337972 NA False True Keratinization 338657 CCDC84 False True NA 338785 NA False True Keratinization;Formation of the cornified envelope 339287 MSL1 False True HATs acetylate histones 339302 CPLX4 False True NA 340156 MYLK4 False True NA 340348 TSPAN33 False True Amyloid fiber formation 340359 KLHL38 False True NA 342667 STAC2 False True NA 342979 NA False True NA 345651 ACTBL2 False True NA 345778 NA False True NA 347517 RAB41 False True Intra-Golgi traffic;RAB geranylgeranylation 347688 TUBB8 False True Translocation of SLC2A4 (GLUT4) to the plasma membrane;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;Gap junction assembly;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HSP90 chaperone cycle for steroid hormone receptors (SHR);Recruitment of NuMA to mitotic centrosomes;Recycling pathway of L1;Recycling pathway of L1;Cilium Assembly;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;Carboxyterminal post-translational modifications of tubulin;Carboxyterminal post-translational modifications of tubulin;Activation of AMPK downstream of NMDARs;Kinesins 347733 TUBB2B False True Translocation of SLC2A4 (GLUT4) to the plasma membrane;Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane;Gap junction assembly;MHC class II antigen presentation;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;HSP90 chaperone cycle for steroid hormone receptors (SHR);Recruitment of NuMA to mitotic centrosomes;Prefoldin mediated transfer of substrate to CCT/TriC;Formation of tubulin folding intermediates by CCT/TriC;Post-chaperonin tubulin folding pathway;Recycling pathway of L1;Recycling pathway of L1;Hedgehog 'off' state;Cilium Assembly;Intraflagellar transport;RHO GTPases activate IQGAPs;RHO GTPases Activate Formins;COPI-mediated anterograde transport;COPI-dependent Golgi-to-ER retrograde traffic;COPI-independent Golgi-to-ER retrograde traffic;Mitotic Prometaphase;The role of GTSE1 in G2/M progression after G2 checkpoint;Carboxyterminal post-translational modifications of tubulin;Carboxyterminal post-translational modifications of tubulin;Activation of AMPK downstream of NMDARs;Kinesins 347734 NA False True Transport and synthesis of PAPS;Transport of nucleotide sugars 348110 NA False True NA 353142 NA False True Formation of the cornified envelope 373156 GSTK1 False True Glutathione conjugation;Peroxisomal protein import;Peroxisomal protein import 374454 NA False True Keratinization;Formation of the cornified envelope 374897 NA True False NA 375035 NA False True NA 375056 MIA3 False True Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);Cargo concentration in the ER;Post-translational protein phosphorylation 375248 NA False True NA 375484 SIMC1 False True NA 375593 NA False True NA 378108 TRIM74 False True NA 378884 NHLRC1 False True Glycogen synthesis;Myoclonic epilepsy of Lafora 386617 NA False True NA 386675 KRTAP10-7 False True Keratinization 386676 KRTAP10-9 False True Keratinization 386682 KRTAP10-3 False True Keratinization 387082 SUMO4 False True NA 387521 TMEM189 False True NA 387522 TMEM189-UBE2V1 False True NOD1/2 Signaling Pathway;TICAM1, RIP1-mediated IKK complex recruitment ;Downstream TCR signaling;FCERI mediated NF-kB activation;TAK1 activates NFkB by phosphorylation and activation of IKKs complex;activated TAK1 mediates p38 MAPK activation;JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1;CLEC7A (Dectin-1) signaling;Interleukin-1 signaling;IRAK1 recruits IKK complex;IKK complex recruitment mediated by RIP1;TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling;IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation;Antigen processing: Ubiquitination & Proteasome degradation 387923 NA False True NA 388524 NA False True NA 388591 RNF207 False True NA 388677 NOTCH2NL False True NA 388697 NA True False Neutrophil degranulation 388698 NA True False Neutrophil degranulation 388818 KRTAP26-1 False True Keratinization 389084 NA False True NA 389362 PSMG4 False True NA 389840 MAP3K15 False True NA 390535 NA False True NA 390637 GDPGP1 False True NA 390916 NA False True Peroxisomal lipid metabolism;Peroxisomal protein import;Peroxisomal protein import 397519 NA False True NA 399396 nedd4l False True NA 399687 MYO18A False True Signaling by cytosolic FGFR1 fusion mutants;Signaling by FGFR1 in disease 401152 C4orf3 False True NA 401466 NA False True NA 401541 CENPP False True Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal;Separation of Sister Chromatids;Resolution of Sister Chromatid Cohesion;RHO GTPases Activate Formins;Deposition of new CENPA-containing nucleosomes at the centromere;Mitotic Prometaphase 404734 NA False True NA 414059 NA False True NA 414318 C9orf106 False True NA 415116 NA False True NA 440434 NA False True NA 440482 NA False True NA 440574 MINOS1 False True Cristae formation 440686 NA False True NA 440915 POTEKP False True NA 441282 NA False True Estrogen biosynthesis 441518 NA False True NA 448834 NA True False NA 493856 CISD2 False True NA 497049 NA False True NA 542767 NA False True NA 548596 CKMT1A False True Creatine metabolism 553115 PEF1 False True NA 554313 NA False True Meiotic synapsis;Packaging Of Telomere Ends;Pre-NOTCH Transcription and Translation;Formation of the beta-catenin:TCF transactivating complex;Formation of the beta-catenin:TCF transactivating complex;PRC2 methylates histones and DNA;Condensation of Prophase Chromosomes;Oxidative Stress Induced Senescence;Senescence-Associated Secretory Phenotype (SASP);DNA Damage/Telomere Stress Induced Senescence;HDACs deacetylate histones;PKMTs methylate histone lysines;HDMs demethylate histones;HATs acetylate histones;HATs acetylate histones;RMTs methylate histone arginines;SIRT1 negatively regulates rRNA expression;ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;NoRC negatively regulates rRNA expression;NoRC negatively regulates rRNA expression;SUMOylation of chromatin organization proteins;B-WICH complex positively regulates rRNA expression;DNA methylation;Transcriptional regulation by small RNAs;Activation of anterior HOX genes in hindbrain development during early embryogenesis;Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;Nonhomologous End-Joining (NHEJ);Processing of DNA double-strand break ends;Deposition of new CENPA-containing nucleosomes at the centromere;G2/M DNA damage checkpoint;RNA Polymerase I Promoter Opening;RNA Polymerase I Chain Elongation;RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;RUNX1 regulates transcription of genes involved in differentiation of HSCs;Estrogen-dependent gene expression;Meiotic recombination;Amyloid fiber formation 574040 NA False True NA 643752 NA False True NA 645432 NA False True NA 653234 NA False True NA 653268 NA False True NA 653404 FOXD4L6 False True NA 653499 NA True False NA 653505 NA False True NA 653509 SFTPA1 False True Toll Like Receptor 4 (TLR4) Cascade;Toll Like Receptor TLR1:TLR2 Cascade;Signal regulatory protein family interactions;Surfactant metabolism;Regulation of TLR by endogenous ligand;Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5);Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4) 654364 NME1-NME2 False True Interconversion of nucleotide di- and triphosphates;Neutrophil degranulation 727897 MUC5B True True Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC);Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS);Defective GALNT12 causes colorectal cancer 1 (CRCS1);Dectin-2 family;O-linked glycosylation of mucins;Termination of O-glycan biosynthesis 728642 CDK11A False True Recruitment of mitotic centrosome proteins and complexes 729092 NA False True NA 851752 SUP35 False True NA 853344 GSH1 False True NA 854708 NA False True NA 855054 NA False True NA 951476 NA False True NA 2540051 NA False True NA 100009506 ACTA1 False True NA 100128588 LOC100128588 False True NA 100129271 NA True False NA 100342572 LOC100342572 False True NA 100506742 CASP12 False True NA 100507436 MICA False True Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 100526693 ARPC4-TTLL3 False True NA 100526737 NA False True RUNX2 regulates bone development 100532736 MINOS1-NBL1 False True NA 100996928 NA False True NA 101929876 LOC101929876 False True NA 101930400 LOC101930400 False True NA 102288414 NA False True NA NA NA True False NA