Mercurial > repos > proteore > proteore_expression_levels_by_tissue
diff README.rst @ 8:2c0bab71a436 draft
planemo upload commit 5e13878e9679f3f5ba8e482b9108249a43f3355e-dirty
author | proteore |
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date | Tue, 18 Dec 2018 09:48:29 -0500 |
parents | f294fd77b143 |
children | 0a0f6c37f05e |
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--- a/README.rst Fri Mar 23 10:28:16 2018 -0400 +++ b/README.rst Tue Dec 18 09:48:29 2018 -0500 @@ -1,4 +1,4 @@ -Wrapper for Get expression data by tissue Tool +Wrapper for Get expression profiles by tissue Tool ================================================= **Authors** @@ -13,11 +13,9 @@ ------------------------------------------------- -This tool retrieve information from Human Protein Atlas (https://www.proteinatlas.org/) -regarding the expression profiles of human genes both on the mRNA and protein level. +This tool retrieve information from Human Protein Atlas (https://www.proteinatlas.org/) regarding the expression profiles of human genes both on the mRNA and protein level. -A list of ENSG (Ensembl gene) IDs must be entered (either via a copy/paste or by choosing a file), -if it's not the case, please use the ID_Convert tool from ProteoRE. +A list of ENSG (Ensembl gene) IDs must be entered (either via a copy/paste or by choosing a file), if it's not the case, please use the ID_Convert tool from ProteoRE. The resources from Human Protein Atlas that can be queried are the following: @@ -31,25 +29,4 @@ The tab-separated file includes Ensembl gene identifier ("Gene"), gene name ("Gene name"), tumor name ("Cancer"), the number of patients annotated for different staining levels ("High", "Medium", "Low" & "Not detected") and log-rank p values for patient survival and mRNA correlation ("prognostic - favourable", "unprognostic - favourable", "prognostic - unfavourable", "unprognostic - unfavourable"). - The data is based on The Human Protein Atlas version 18 and Ensembl version 88.38. - ------ - -**Reliability score** - -Reliability score is divided into Enhanced, Supported, Approved, or Uncertain with respect -to the definitions from HPA: - -Enhanced - One or several antibodies with non-overlapping epitopes targeting the same gene -have obtained enhanced validation based on orthogonal or independent antibody validation method. - -Supported - Consistency with RNA-seq and/or protein/gene characterization data, -in combination with similar staining pattern if independent antibodies are available. - -Approved - Consistency with RNA-seq data in combination with inconsistency with, or lack of, -protein/gene characterization data. Alternatively, consistency with protein/gene characterization data -in combination with inconsistency with RNA-seq data. If independent antibodies are available, -the staining pattern is partly similar or dissimilar. - -Uncertain - Inconsistency with, or lack of, RNA-seq and/or protein/gene characterization data, -in combination with dissimilar staining pattern if independent antibodies are available. + The data is based on The Human Protein Atlas version 18 and Ensembl version 88.38. \ No newline at end of file