Repository paralyzer
Name: paralyzer
Owner: rnateam
Synopsis: A method to generate a high resolution map of interaction sites between RNA-binding proteins and their targets.
We developed the PARalyzer algorithm to generate a high resolution
map of interaction sites between RNA-binding proteins and their targets. The
algorithm utilizes the deep sequencing reads generated by PAR-CLIP
(Photoactivatable-Ribonucleoside-Enhanced Crosslinking and
Immunoprecipitation) protocol.The use of photoactivatable nucleotides in the
PAR-CLIP protocol results in more efficient crosslinking between the
RNA-binding protein and its target relative to other CLIP methods; in addition
a nucleotide substitution occurs at the site of crosslinking, providing for
single-nucleotide resolution binding information. PARalyzer utilizes this
nucleotide substition in a kernel density estimate classifier to generate
the high resolution set of Protein-RNA interaction sites.
Type: unrestricted
Revision: 1:f880686a9194
This revision can be installed: True
Times cloned / installed: 1626

Contents of this repository

Name Description Version Minimum Galaxy Version
A method to map interaction sites between RNA-binding proteins and their targets 1.5 16.01

Categories
RNA - Utilities for RNA