Mercurial > repos > guerler > spring_mcc
view test-data/model/SPIKE_SARS2.hhr @ 0:c3e9ffb4c98a draft
"planemo upload commit 6158473dbced09024b0a805a7df2c93d47705d87"
| author | guerler |
|---|---|
| date | Tue, 23 Mar 2021 13:56:55 +0000 |
| parents | |
| children |
line wrap: on
line source
Query sp|P0DTC2|SPIKE_SARS2 Spike glycoprotein OS=Severe acute respiratory syndrome coronavirus 2 OX=2697049 GN=S PE=1 SV=1 Match_columns 1273 No_of_seqs 1 out of 1 Neff 1 Searched_HMMs 82491 Date Thu Nov 12 20:44:30 2020 Command hhsearch -e 0.001 -i /galaxy-repl/main/files/047/416/dataset_47416633.dat -d hhdb -o /galaxy-repl/main/files/047/416/dataset_47416669.dat No Hit Prob E-value P-value Score SS Cols Query HMM Template HMM 1 6X29_A Spike glycoprotein; Tri 100.0 3E-269 4E-274 2251.1 0.0 1198 16-1213 1-1198(1273) 2 6CS2_B Spike glycoprotein,Enve 100.0 3E-221 4E-226 1857.5 0.0 1161 31-1213 22-1182(1215) 3 6Q04_B Spike glycoprotein; Cor 100.0 2E-204 2E-209 1723.9 0.0 1150 31-1224 65-1321(1359) 4 5I08_C Spike glycoprotein; cor 100.0 2E-199 2E-204 1685.1 0.0 1142 30-1223 29-1293(1299) 5 5X5F_B S protein; MERS-CoV, sp 100.0 6E-198 7E-203 1670.1 0.0 1163 14-1220 12-1286(1323) 6 6VSJ_A Spike glycoprotein, Car 100.0 2E-195 3E-200 1649.5 0.0 1145 9-1204 22-1267(1275) 7 6VSJ_C Spike glycoprotein, Car 100.0 2E-195 3E-200 1649.5 0.0 1145 9-1204 22-1267(1275) 8 6OHW_A Spike surface glycoprot 100.0 7E-190 9E-195 1602.1 0.0 1144 2-1204 13-1299(1322) 9 6NZK_A Spike surface glycoprot 100.0 7E-190 9E-195 1602.1 0.0 1144 2-1204 13-1299(1322) 10 6M15_A Spike glycoprotein; VIR 100.0 6E-154 7E-159 1294.0 0.0 832 273-1215 216-1070(1118) 11 6M15_B Spike glycoprotein; VIR 100.0 6E-154 7E-159 1294.0 0.0 832 273-1215 216-1070(1118) 12 6JX7_A Feline Infectious Perit 100.0 2E-132 2E-137 1149.2 0.0 664 525-1216 674-1394(1468) 13 5SZS_A Spike glycoprotein; cor 100.0 7E-131 9E-136 1128.9 0.0 662 505-1215 575-1283(1325) 14 6IXB_B Spike glycoprotein; Alp 100.0 8E-129 1E-133 1101.7 0.0 647 518-1214 426-1116(1116) 15 6CV0_A Spike protein; infectio 100.0 3E-125 3E-130 1068.9 0.0 651 524-1212 399-1074(1105) 16 6VV5_C Spike glycoprotein; gly 100.0 2E-124 2E-129 1078.6 0.0 641 521-1213 614-1309(1356) 17 6M3W_B Spike glycoprotein,Spik 100.0 2E-124 2E-129 1000.4 0.0 491 706-1196 1-491 (491) 18 6U7K_C Spike glycoprotein; PED 100.0 1E-122 1E-127 1065.5 0.0 641 521-1213 629-1324(1399) 19 6BFU_C Spike protein; coronavi 100.0 4E-119 4E-124 1017.5 0.0 746 267-1148 240-1022(1024) 20 6B3O_B Spike glycoprotein; Cor 100.0 7E-117 9E-122 954.9 0.0 497 703-1203 45-560 (605) 21 6PZ8_A S protein, G2 heavy cha 100.0 8E-112 1E-116 897.4 0.0 445 694-1140 12-470 (472) 22 6PZ8_F S protein, G2 heavy cha 100.0 3.1E-74 3.8E-79 636.3 0.0 621 14-676 12-724 (726) 23 7BZ5_A Spike protein S1, Heavy 100.0 3.5E-52 4.2E-57 416.5 0.0 225 319-543 1-225 (229) 24 6YZ5_E Spike glycoprotein, Nan 100.0 3.5E-51 4.3E-56 405.6 0.0 205 330-534 1-205 (210) 25 6YLA_E SARS-CoV-2 RBD, Heavy C 100.0 3.8E-51 4.6E-56 406.0 0.0 207 328-534 2-208 (213) 26 6ZFO_A SARS-CoV-2 RBD, Nanobod 100.0 2.3E-47 2.8E-52 375.2 0.0 194 333-526 1-194 (194) 27 2GHV_C Spike glycoprotein; SAR 100.0 3.9E-37 4.7E-42 305.0 0.0 197 330-527 4-200 (203) 28 1WYY_A E2 Glycoprotein; membra 100.0 2.3E-36 2.8E-41 288.5 0.0 99 903-1001 3-101 (149) 29 1WYY_B E2 Glycoprotein; membra 100.0 2.3E-36 2.8E-41 288.5 0.0 99 903-1001 3-101 (149) 30 5X4S_A Spike glycoprotein; SAR 100.0 1.1E-34 1.4E-39 298.0 0.0 261 30-307 21-281 (285) 31 5KWB_A Spike glycoprotein; Cor 100.0 1.2E-33 1.4E-38 297.9 0.0 271 316-592 1-370 (371) 32 6LXT_F Spike protein S2; 2019- 99.9 2.8E-28 3.4E-33 230.5 0.0 112 910-1021 1-113 (132) 33 6LXT_C 2019-nCoV S2 subunit; 2 99.9 2.8E-28 3.4E-33 230.5 0.0 112 910-1021 1-113 (132) 34 6C6Z_A Spike protein, CDC2-C2 99.9 6.9E-26 8.3E-31 228.8 0.0 148 319-472 1-148 (231) 35 5XGR_H Spike protein S1; MERS- 99.8 9.7E-26 1.2E-30 224.7 0.0 181 335-528 2-198 (204) 36 4QZV_B Dipeptidyl peptidase 4 99.8 4.1E-25 5E-30 224.7 0.0 137 319-458 1-139 (246) 37 4L3N_B S protein; beta-sheet f 99.8 2.3E-24 2.8E-29 216.3 0.0 124 334-458 3-126 (216) 38 5YY5_B MERS-CoV RBD, Heavy cha 99.8 3.5E-24 4.2E-29 214.4 0.0 124 334-458 2-125 (209) 39 4L72_B Dipeptidyl peptidase 4 99.8 4E-24 4.8E-29 213.4 0.0 123 335-458 1-123 (204) 40 3R4D_D CEA-related cell adhesi 99.8 5.2E-24 6.3E-29 219.9 0.0 240 30-304 30-283 (288) 41 4NJL_A S protein; six-helix-bu 99.8 1.2E-23 1.4E-28 199.4 0.0 122 910-1035 2-125 (131) 42 6QFY_A Spike glycoprotein; sia 99.8 2.6E-23 3.2E-28 214.7 0.0 236 30-305 29-286 (288) 43 4H14_A Spike glycoprotein; bet 99.8 3.5E-23 4.3E-28 214.0 0.0 235 30-304 29-285 (290) 44 4MOD_B HR1 of S protein, LINKE 99.8 1.9E-22 2.2E-27 191.3 0.0 118 918-1039 2-121 (129) 45 5X4R_A S protein; MERS-CoV, sp 99.7 2.2E-21 2.7E-26 204.5 0.0 263 14-306 12-337 (342) 46 6J11_C Spike glycoprotein, VH 99.7 2.8E-21 3.3E-26 203.4 0.0 262 14-305 12-336 (336) 47 5GYQ_A Spike glycoprotein; bat 99.7 4.2E-21 5E-26 188.9 0.0 108 332-440 2-109 (176) 48 5ZVK_A Human Coronavirus MERS 99.7 7.3E-21 8.9E-26 169.6 0.0 79 910-988 2-80 (80) 49 2BEZ_C E2 GLYCOPROTEIN; MEMBRA 99.6 8.5E-20 1E-24 162.0 0.0 77 914-990 1-77 (77) 50 6M1V_A spike protein; 2019-nCo 99.6 2.8E-19 3.4E-24 168.2 0.0 98 917-1020 1-98 (119) 51 5ZUV_A Spike glycoprotein,EK1, 99.6 1.2E-18 1.5E-23 166.1 0.0 83 914-996 2-98 (133) 52 5YL9_A Spike glycoprotein; Spi 99.5 1.1E-17 1.3E-22 151.9 0.0 74 914-987 2-89 (89) 53 1WDF_B E2 glycoprotein; MHV, c 99.2 2.7E-14 3.2E-19 131.3 0.0 62 919-980 1-62 (95) 54 1ZVA_A E2 glycoprotein; SARS c 99.0 1.7E-13 2.1E-18 121.9 0.0 58 1144-1201 15-77 (77) 55 5ZHY_D Spike glycoprotein,Spik 98.8 7.4E-12 9E-17 122.0 0.0 59 918-976 1-73 (148) 56 5XJK_A Spike protein S2; VIRAL 98.7 1.4E-11 1.7E-16 107.0 0.0 62 777-838 3-64 (65) 57 1ZV8_K E2 glycoprotein; SARS c 98.6 1.2E-10 1.4E-15 98.3 0.0 50 919-968 1-50 (50) 58 2IEQ_B Spike glycoprotein; Hum 98.5 1.3E-10 1.5E-15 109.6 0.0 84 921-1005 7-99 (109) 59 2FXP_A Spike glycoprotein; Pre 98.5 1.6E-10 2E-15 98.2 0.0 54 1158-1211 2-55 (55) 60 1WDG_B E2 glycoprotein; MHV, c 98.5 2.2E-10 2.6E-15 106.1 0.0 54 919-972 1-56 (94) 61 2BEQ_D E2 GLYCOPROTEIN; VIRAL 98.4 5.2E-10 6.3E-15 93.7 0.0 47 1166-1212 2-48 (48) 62 2BEQ_E E2 GLYCOPROTEIN; VIRAL 98.4 5.2E-10 6.3E-15 93.7 0.0 47 1166-1212 2-48 (48) 63 6LXT_F Spike protein S2; 2019- 97.7 1.4E-07 1.7E-12 91.8 0.0 45 1163-1207 87-131 (132) 64 6LXT_C 2019-nCoV S2 subunit; 2 97.7 1.4E-07 1.7E-12 91.8 0.0 45 1163-1207 87-131 (132) 65 4MOD_B HR1 of S protein, LINKE 97.5 4.8E-07 5.8E-12 88.0 0.0 64 1142-1205 40-123 (129) 66 1ZVB_A E2 glycoprotein; SARS c 97.3 1.9E-06 2.2E-11 69.0 0.0 34 958-991 1-34 (34) 67 1WDG_B E2 glycoprotein; MHV, c 97.1 5.1E-06 6.2E-11 77.9 0.0 47 1156-1202 44-94 (94) 68 6M1V_A spike protein; 2019-nCo 97.0 8.6E-06 1E-10 78.8 0.0 49 1157-1205 67-115 (119) 69 2BEQ_C E2 GLYCOPROTEIN; VIRAL 97.0 9.9E-06 1.2E-10 66.1 0.0 36 932-967 2-37 (38) 70 5ZVM_c Human Coronavirus SARS 96.7 2.6E-05 3.2E-10 65.3 0.0 41 1165-1205 4-44 (44) 71 5ZVM_b Human Coronavirus SARS 96.7 2.6E-05 3.2E-10 65.3 0.0 41 1165-1205 4-44 (44) 72 2BEZ_F E2 GLYCOPROTEIN; MEMBRA 96.4 8.7E-05 1.1E-09 61.4 0.0 42 1160-1201 1-42 (42) 73 6LVN_B 2019-nCoV S2 subunit; 2 96.2 0.00019 2.3E-09 58.1 0.0 35 1169-1203 2-36 (36) 74 1ZV8_B E2 glycoprotein; SARS c 96.2 0.00019 2.3E-09 58.1 0.0 35 1169-1203 2-36 (36) 75 6LVN_A Spike protein S2; 2019- 96.2 0.00019 2.3E-09 58.1 0.0 35 1169-1203 2-36 (36) 76 5YL9_B Spike glycoprotein; Spi 91.7 0.063 7.7E-07 48.0 0.0 41 1158-1201 4-58 (59) 77 5ZUV_A Spike glycoprotein,EK1, 89.5 0.16 2E-06 51.2 0.0 44 1161-1204 90-133 (133) 78 6MAR_D Immunoglobulin G PGT151 71.2 3 3.7E-05 42.9 0.0 29 1199-1227 154-183 (220) 79 6DCQ_D Envelope glycoprotein g 68.2 3.9 4.7E-05 45.1 0.0 49 1197-1245 146-195 (352) 80 6NIJ_B PGT145 Fab heavy chain, 68.2 3.9 4.7E-05 44.9 0.0 51 1197-1247 146-197 (345) 81 1WDF_B E2 glycoprotein; MHV, c 63.1 5.7 7E-05 39.1 0.0 56 1144-1202 40-95 (95) 82 6GY6_C XaxA, XaxB; bacterial t 58.0 8.2 9.9E-05 41.0 0.0 24 1172-1195 232-255 (424) 83 6OJ7_A Fusion glycoprotein F0; 57.5 8.5 0.0001 34.2 0.0 29 927-955 17-45 (53) 84 1G2C_W TWO HEPTAD REPEATS OF H 57.5 8.5 0.0001 34.1 0.0 29 927-955 17-45 (52) 85 6NYX_H Fusion glycoprotein F0; 57.3 8.6 0.0001 34.1 0.0 29 927-955 17-45 (53) 86 6O40_A Fusion glycoprotein F0; 57.3 8.6 0.0001 34.1 0.0 29 927-955 17-45 (53) 87 6GY8_A XaxA; bacterial toxin, 55.0 10 0.00012 39.7 0.0 22 1173-1194 233-254 (408) 88 6PWU_E Envelope glycoprotein g 52.0 12 0.00014 46.6 0.0 53 1196-1248 651-704 (858) 89 3EUH_B Chromosome partition pr 52.0 12 0.00014 44.2 0.0 126 858-988 125-264 (440) 90 3MAW_A Fusion glycoprotein F0; 50.7 13 0.00016 44.0 0.0 76 875-955 83-158 (483) 91 6EK7_A YaxA; pathogens, pore f 49.9 14 0.00017 39.3 0.0 23 1172-1194 234-256 (410) 92 1SVF_C SV5 FUSION PROTEIN; PAR 49.4 14 0.00017 34.0 0.0 29 927-955 26-54 (64) 93 1SVF_A SV5 FUSION PROTEIN; PAR 49.4 14 0.00017 34.0 0.0 29 927-955 26-54 (64) 94 2FYZ_E Fusion glycoprotein F0; 48.5 15 0.00018 33.8 0.0 29 927-955 29-57 (63) 95 2B9B_B Parainfluenza Virus 5 F 48.3 15 0.00018 43.7 0.0 76 875-955 79-154 (497) 96 5YZC_B glycoprotein F2, glycop 47.2 16 0.00019 42.7 0.0 73 878-955 1-73 (419) 97 1T98_B Chromosome partition pr 46.8 16 0.0002 41.3 0.0 104 858-966 125-236 (287) 98 1T98_A Chromosome partition pr 46.8 16 0.0002 41.3 0.0 104 858-966 125-236 (287) 99 1G5G_F FUSION PROTEIN; fusion 45.6 18 0.00021 42.9 0.0 76 875-955 83-158 (481) 100 5EVM_F Fusion glycoprotein F0; 45.4 18 0.00022 43.4 0.0 76 875-955 107-182 (529) 101 6T3F_F Fusion glycoprotein F0, 42.9 21 0.00025 42.7 0.0 76 875-955 85-160 (502) 102 3N27_B Fusion glycoprotein F0, 42.7 21 0.00025 34.6 0.0 28 927-954 18-45 (80) 103 1ZTM_C Fusion glycoprotein; fu 42.5 21 0.00026 42.4 0.0 75 876-955 90-164 (490) 104 4GIP_D Fusion glycoprotein F2, 42.0 22 0.00026 41.5 0.0 72 878-955 1-73 (409) 105 6H2E_Q AhlB; Tripartite pore-f 41.7 22 0.00027 35.5 0.0 23 1173-1195 128-150 (274) 106 5IJO_G Nuclear pore complex pr 40.4 24 0.00029 42.7 0.0 55 1133-1189 239-293 (599) 107 1WP7_A fusion protein; Nipah V 40.3 24 0.00029 34.8 0.0 28 927-954 18-45 (89) 108 1WP8_C fusion; Hendra Virus, F 39.6 25 0.00031 34.6 0.0 28 927-954 18-45 (89) 109 6R1J_J AhlB; Tripartite pore-f 39.2 26 0.00031 34.8 0.0 24 1172-1195 127-150 (272) 110 6C14_A Protocadherin-15, LHFPL 38.6 27 0.00032 35.4 0.0 26 1108-1133 82-109 (337) 111 5EJB_D Fusion glycoprotein F0; 38.0 28 0.00034 41.7 0.0 76 875-955 82-157 (501) 112 2M8R_A Syntaxin-1A; syntaxin, 36.7 30 0.00036 29.7 0.0 12 1211-1222 84-95 (109) 113 3HD7_B Vesicle-associated memb 36.7 30 0.00036 29.7 0.0 12 1211-1222 84-95 (109) 114 5C3L_B Nucleoporin Nup54, MGC8 34.3 35 0.00042 32.1 0.0 57 1131-1189 6-62 (142) 115 5G6U_A LANGERIN; CARBOHYDRATE 33.0 38 0.00046 33.5 0.0 42 1038-1090 123-164 (261) 116 3IPD_E Vesicle-associated memb 26.9 56 0.00068 28.7 0.0 9 1212-1220 68-76 (91) 117 3HD7_A Vesicle-associated memb 26.9 56 0.00068 28.7 0.0 9 1212-1220 68-76 (91) 118 6BP2_B Envelope Glycoprotein G 24.9 64 0.00078 35.3 0.0 40 925-964 122-161 (202) 119 6QD8_D Light chain, Virion spi 23.5 72 0.00087 33.9 0.0 34 931-964 61-94 (168) 120 4NJL_A S protein; six-helix-bu 22.6 76 0.00092 33.2 0.0 27 1178-1204 104-130 (131) 121 4LWS_B Uncharacterized protein 22.2 79 0.00095 26.3 0.0 32 955-986 54-85 (103) 122 2NRJ_A Hbl B protein; Enteroto 21.9 80 0.00097 32.4 0.0 15 1205-1219 194-208 (346) 123 2N2A_B Receptor tyrosine-prote 21.7 81 0.00099 26.9 0.0 23 1206-1228 1-23 (58) 124 6F5U_B Envelope glycoprotein,G 21.4 83 0.001 33.1 0.0 38 927-964 57-94 (168) 125 5F1B_B GP1, GP2, Niemann-Pick 21.4 84 0.001 31.9 0.0 37 929-965 52-88 (130) 126 6HS4_B Envelope glycoprotein,E 21.3 84 0.001 33.1 0.0 40 925-964 55-94 (168) 127 2KG7_A Uncharacterized protein 21.1 85 0.001 25.8 0.0 66 923-988 14-80 (97) 128 6W08_B NSP15 endoribnuclease; 20.9 87 0.0011 32.8 0.0 55 1139-1193 122-184 (359) 129 3OGI_C Putative ESAT-6-like pr 20.4 90 0.0011 26.8 0.0 66 921-986 11-77 (101) 130 5HJ3_L Envelope glycoprotein, 20.1 93 0.0011 31.8 0.0 35 930-964 60-94 (136) 131 6RX1_A Syncytin-1; HUMAN PLACE 20.0 93 0.0011 31.0 0.0 53 908-964 12-64 (108) No 1 >6X29_A Spike glycoprotein; Trimer, VIRAL PROTEIN; 2.7A {Severe acute respiratory syndrome coronavirus 2} Probab=100.00 E-value=2.9e-269 Score=2251.14 Aligned_cols=1198 Identities=99% Similarity=1.476 Sum_probs=961.9 Template_Neff=3.900 Q sp|P0DTC2|SPIK 16 VNLTTRTQLPPAYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNGTKRFDNPVLPFNDGVYFAST 95 (1273) Q Consensus 16 vnlttrtqlppaytnsftrgvyypdkvfrssvlhstqdlflpffsnvtwfhaihvsgtngtkrfdnpvlpfndgvyfast 95 (1273) |||||||||||+||.+..+|+||||..++|++.+.+|+||+|+.+++++++|||++|++....+++++.||+||+|+... T Consensus 1 ~~~~~~~~~~~~~~~~~~~g~yYpd~~~~sn~t~l~qglfp~~~s~~~~y~~~~~~gt~~~~~y~~~~~~F~dGifv~v~ 80 (1273) T 6X29_A 1 VNLTTRTQLPPAYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNGTKRFDNPVLPFNDGVYFAST 80 (1273) T ss_dssp -----------CEEECCSCCCBCCSSEECCSEEEEEEEEECCTTCEEECCCCCC----------CCCCEECTTCEEEEEE T ss_pred CCcccccCCCCCcccccceeeEeeCCeeEeecccccccccCCCCCCceEEeeEEeecCCcccccCCCCcccCCeEEEEee Confidence 69999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 96 EKSNIIRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVYYHKNNKSWMESEFRVYSSANNCTFEYVSQPF 175 (1273) Q Consensus 96 eksniirgwifgttldsktqsllivnnatnvvikvcefqfcndpflgvyyhknnkswmesefrvyssannctfeyvsqpf 175 (1273) +++|..++|+||+|.+.++++++|+++.+.+.|.+|.|++|..|++.++++.+|.+|+|++++.|..++||+|+|..|+| T Consensus 81 ~~~n~~p~~~fGstf~n~s~tvvI~P~~~~~~it~C~~~vC~~p~~~~~~~~g~~~~~~~~~~~~~~~~nc~f~~~~~nf 160 (1273) T 6X29_A 81 EKSNIIRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVYYHKNNKSWMESEFRVYSSANNCTFEYVSQPF 160 (1273) T ss_dssp ESSCCEEEEEEESSCSSSSCCCEEEECSSCEEEECCCCCCCSSCCEEC---------------------CCCCEEEC--- T ss_pred ecccCcceEeEEeccCCCcEEEEEeCCCcceEEEEEEEEecCCCeeEEEeecCCceeeeeehhhhccCCCceEEEecCCc Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 176 LMDLEGKQGNFKNLREFVFKNIDGYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHRSYLTPGDSS 255 (1273) Q Consensus 176 lmdlegkqgnfknlrefvfknidgyfkiyskhtpinlvrdlpqgfsaleplvdlpiginitrfqtllalhrsyltpgdss 255 (1273) .||.+.++|+|...++|+|++.||+|.+|..+++++..+.+|+|+..+.|..++|+|+||+|+|.++.+.|++.+|++.+ T Consensus 161 t~d~~~~~~~~~~~~~~~F~~~dG~f~iY~~~~~~~~~~~~~~~~~~~~yy~~~p~g~n~~~~~~~~~~~~~~~~~~~~~ 240 (1273) T 6X29_A 161 LMDLEGKQGNFKNLREFVFKNIDGYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHRSYLTPGDSS 240 (1273) T ss_dssp ----------CCEEEEEEEEEETTEEEEEEEEEECCCSSSCCSSCCCBEEEEEEECCCCCSEEEEEEEEC---------- T ss_pred eeccccCccceeeeEeEEEEecCCeEEEEEeCCCCcccccCCccccccchhhcCCCCCccccceeEEEeeeecCCCCCCC Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999889 Q sp|P0DTC2|SPIK 256 SGWTAGAAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNL 335 (1273) Q Consensus 256 sgwtagaaayyvgylqprtfllkynengtitdavdcaldplsetkctlksftvekgiyqtsnfrvqptesivrfpnitnl 335 (1273) ++|+.+.++|||+||+||+|||+|++||.||+||||+.||++|.||..+||++++|+|++|+||+||...++|+++++.. T Consensus 241 ~~~~~~~~~~yV~~L~~r~yLl~fd~nG~It~AvDCa~~~~sEL~Cst~SF~p~tGVY~lS~yraqP~~~V~~~~~~~~~ 320 (1273) T 6X29_A 241 SGWTAGAAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNL 320 (1273) T ss_dssp -------CCEEECCCEEEEEEEEECTTSCEEEECCTTSCHHHHHHHHHTCSSCCSEEEEEEEEECCCCCCCEECCCCCCB T ss_pred cccceeeeEEEEEeccceeEEEeecCCCeEeEEEecccCcchhceeEecceecCCcEEeccCeEEEeceEEEEcCCCCCC Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 336 CPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQT 415 (1273) Q Consensus 336 cpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptklndlcftnvyadsfvirgdevrqiapgqt 415 (1273) |+|.+++++.++.++|.|.|++++||..|+++|++..++++|+||||+|.||.++||..|++|.|.|..++.++++||++ T Consensus 321 C~~~~~~~~~~~Psp~~w~R~~fsNCnfn~s~Lls~~~~~~f~C~~ispskL~~mCfssvtiD~F~ip~~~~~~l~~g~~ 400 (1273) T 6X29_A 321 CPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVCPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQT 400 (1273) T ss_dssp CCCHHHHTCSSCCCGGGCEEEEECSSBCCHHHHHHCSCCSEEEESSSCGGGGTTCCCSEEEEEEEEECGGGGTTCSTTCC T ss_pred CChhHHhcCCCCCCcceeEEEEEecCCCcHHHHhhccccceeEEeCCCHHHhcccccCeeEEEEEEecccceeecCCCCC Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 416 GKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSY 495 (1273) Q Consensus 416 gkiadynyklpddftgcviawnsnnldskvggnynylyrlfrksnlkpferdisteiyqagstpcngvegfncyfplqsy 495 (1273) |.|++||||+|+||+||+++|+.++++..+.++|||++|.+++++++|||||+++|+||.+.++|+...|.+|++|+..+ T Consensus 401 g~i~~yNYkl~~~~~~C~l~~~~~~~~~~~t~~y~~~~~~~~~~~~~~~~~~~~~~~y~~~~~~C~~~~~~~C~~pl~~~ 480 (1273) T 6X29_A 401 GKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSY 480 (1273) T ss_dssp STTTTTTCCCCTTCCEEEEEEECTTTTCC--CBCCCEEC-------CTTCCCC--------------------CCSCEEC T ss_pred cHHHhcCcCCCCCCCCeEEEEEeCCcccCCcccHHHHHHhcccCCCCcccCCCchhhhcCCCCCCCCCCcccceeccccc Confidence 99999999999999999999999999998999999999999999999999999999999999999976799999999999 Q sp|P0DTC2|SPIK 496 GFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDA 575 (1273) Q Consensus 496 gfqptngvgyqpyrvvvlsfellhapatvcgpkkstnlvknkcvnfnfngltgtgvltesnkkflpfqqfgrdiadttda 575 (1273) ++....|++++.+++++++++....|++|||.+..++++.++||++|..|.||+||++++|..+..+|.||.++.|+..+ T Consensus 481 ~~~~~~g~~~~c~~lv~IT~~~t~~~~~Vc~~~~~snI~LnvCVdYNIYGiTGqGVItntn~t~~~~q~~gl~~~g~s~g 560 (1273) T 6X29_A 481 GFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDA 560 (1273) T ss_dssp CBCTTC-CTTSCEEEEEEEEECCSSCCCCCCSCCCCCCCCSSEECCEETTEECCEEEEECCCCCCTTCCEEECTTSCEEE T ss_pred ceecCCcccceeeEEEEEEEecCCCCCcccCCcCCceeEeceEEeeEeCCceeEEEEEecCCCCccchhcceecCCCcce Confidence 88888999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 576 VRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEH 655 (1273) Q Consensus 576 vrdpqtleilditpcsfggvsvitpgtntsnqvavlyqdvnctevpvaihadqltptwrvystgsnvfqtragcligaeh 655 (1273) +|++.++++..|+||..+.++|+..|+|+++|+|+||..+||++++.++++.+++|.|++++++++.||||+||++||.+ T Consensus 561 FKn~ttG~~YsV~PC~~~~QsVVy~g~~~s~q~AgL~tSinCt~v~~~~~s~~~t~~fy~~s~~~~~~~T~~gcv~na~~ 640 (1273) T 6X29_A 561 VRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEH 640 (1273) T ss_dssp EECSSSCCEEEEECCCEEEEEEEECCTTTCSCCEEEEETCCTTCC--------------------CEEECSSEEEESCEE T ss_pred EECCCCCCEEEEEeCcccceEEEcCCCCCcceEEEEEeccCCCCCcceeeccccCCeeEEEeCCCCceeeceeEeeccee Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 656 VNNSYECDIPIGAGICASYQTQTNSPRRARSVASQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTS 735 (1273) Q Consensus 656 vnnsyecdipigagicasyqtqtnsprrarsvasqsiiaytmslgaensvaysnnsiaiptnftisvtteilpvsmtkts 735 (1273) .++..+|+.|+|.|||+.+.+...+++..+.+....+..|+|.+..+..++.+...|.||+||||+|++|.++++|.|.+ T Consensus 641 ~t~~~~C~~Pvg~giC~d~~~~~~~~~s~~~~~~~~l~~~~~p~~~~~~~~~~~~~i~IP~nFtlsvt~EyiQt~~~kVs 720 (1273) T 6X29_A 641 VNNSYECDIPIGAGICASYQTQTNSPGSASSVASQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTS 720 (1273) T ss_dssp CSSCCCCSEEEETTEEEEEEC------------CCEEEEEECCCSCEEECCCCTTEEEEEEEEEEEEEEEEEECCCCCEE T ss_pred cCCCCcCCCCceEEEeecCCccCCCCCccccccceeEEeeeccCCccccccccceEEEccCCeEEEEEEEEeeecCCceE Confidence 99999999999999999999843333323345667888999988887888899999999999999999999999999999 Q sp|P0DTC2|SPIK 736 VDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQILPDPSKPSKR 815 (1273) Q Consensus 736 vdctmyicgdstecsnlllqygsfctqlnraltgiaveqdkntqevfaqvkqiyktppikdfggfnfsqilpdpskpskr 815 (1273) |||.+|+|||+.+|.+||.|||+||..+|+||.|.+..+|.+..+++..+++.++++.+.+|+||||+.+||.+++|++| T Consensus 721 IDC~~YVC~~~~rC~~LL~QYgsfC~~I~~aL~~~a~led~~~~~~~s~~~~~~~~~~~~~~~~fN~s~llp~~~~~~~R 800 (1273) T 6X29_A 721 VDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQILPDPSKPSKR 800 (1273) T ss_dssp ECHHHHHSTTCHHHHHHHGGGCTTHHHHHHHHHHHHHHHHHHHHHHHTTSSSEEECCSSCCSTTCCCTTTSBCTTSSSCC T ss_pred EecchhccCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHhcHHHHHHHHHhhHHhcCCCcccCCCccccccCCCCCCCCCc Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 816 SFIEDLLFNKVTLADAGFIKQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQ 895 (1273) Q Consensus 816 sfiedllfnkvtladagfikqygdclgdiaardlicaqkfngltvlpplltdemiaqytsallagtitsgwtfgagaalq 895 (1273) |+||||||+||+.+|.|+.+.|.+|.++..+|||+|||.|||+.||||++++||++.||++|++|....|||||+++|.. T Consensus 801 SaIEDLLF~KV~t~glG~~~~Yk~Ct~g~~i~DL~CAQyyNGimVLPpv~d~~~~amYTasL~g~m~~gg~T~G~tsaaa 880 (1273) T 6X29_A 801 SFIEDLLFNKVTLADAGFIKQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQ 880 (1273) T ss_dssp BHHHHHHSSSCC--------------------------CCSSEEECCCSSCHHHHHHHHHHHHHHHHHHTTHHHHSSCCC T ss_pred cHHHHHhcCceEeCCCChhHhhHHccCCccHHHHhcccccCcEEEeCCCCCHHHHHHHHHHHHHHHHhcccccCcchhcc Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 896 IPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISS 975 (1273) Q Consensus 896 ipfamqmayrfngigvtqnvlyenqklianqfnsaigkiqdslsstasalgklqdvvnqnaqalntlvkqlssnfgaiss 975 (1273) |||||||.||+||+|+||+||.||||+|||.||.||+.||+.++.|++||.|+|||||++++||++|++||+.||||||| T Consensus 881 iPFa~~vq~RlN~v~lt~~VL~~NQk~iA~sFN~A~~~i~~g~~tts~AL~kiQ~VVN~~~~aL~~L~~QL~nnFgAISS 960 (1273) T 6X29_A 881 IPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISS 960 (1273) T ss_dssp CCHHHHHHHHHHTTTCCTHHHHTTHHHHHHHHHHHHHHHHHHHSSCGGGGHHHHHHHHHHHHHHHHHGGGGGCCTTSSCS T ss_pred chhHHHHHHHhcccccchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhHHHH Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 976 VLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQS 1055 (1273) Q Consensus 976 vlndilsrldkveaevqidrlitgrlqslqtyvtqqliraaeirasanlaatkmsecvlgqskrvdfcgkgyhlmsfpqs 1055 (1273) .++||++|||++||++||||||+|||.+|++||+|||+|++|+|+|+.||..||+|||..||+|.+|||.|.|++|+||. T Consensus 961 SI~dIy~RLD~leAdaQVDRLItGRL~aLnafVtQ~L~~~~evr~sr~LA~qKINECVKsQS~R~gFCGnG~Hi~S~~q~ 1040 (1273) T 6X29_A 961 VLNDILSRLCPPEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQS 1040 (1273) T ss_dssp CHHHHTTTSCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTSSCCCSTTSSSSSEEEECCEEE T ss_pred HHHHHHHhhchhHHHHHHHHHHHhhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhccCcccCcCCCCeeEEecccc Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 1056 APHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNN 1135 (1273) Q Consensus 1056 aphgvvflhvtyvpaqeknfttapaichdgkahfpregvfvsngthwfvtqrnfyepqiittdntfvsgncdvvigivnn 1135 (1273) ||+|++|+|++|+|.+.++.+++|.+|+++++..|++|+|+.|+++|++|.|++|||..||.+|..+...|||....+|+ T Consensus 1041 AP~Gi~F~H~~~~Pt~~~~v~a~~GlC~~~~~~~~~~g~~~~~~~~~~~T~r~~y~P~~~t~~d~v~i~sC~V~y~~vn~ 1120 (1273) T 6X29_A 1041 APHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNN 1120 (1273) T ss_dssp ETTEEEEEEEEEEEEEEEEEECBSCEESSSCEEEESSSEEEESSSSEEEECSSSCCCBCCBTTTEEECSCTTTSTTCEEC T ss_pred CCCeEEEEEEEecccceEEEEEeceEeeCCceeeecceEEEEcCCEEEEcccccccCccCCCCceEEeccceeEEEEecc Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 1136 TVYDPLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIKWP 1213 (1273) Q Consensus 1136 tvydplqpeldsfkeeldkyfknhtspdvdlgdisginasvvniqkeidrlnevaknlneslidlqelgkyeqyikwp 1213 (1273) ++.+|++|++..|+|||+|||||||+|+.++++++.+|++++|++.||++|+|+.|+||+++|||++|++||+|-+++ T Consensus 1121 t~~~~~~pd~~df~~el~~~~~N~t~p~~~~~~~~~~N~T~LNLt~EI~~Lq~~I~~LN~slIDLe~Ln~~e~y~~~~ 1198 (1273) T 6X29_A 1121 TVYDPLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQGSGYI 1198 (1273) T ss_dssp CCBCSHHHHHHC------------------------------------------------------------------ T ss_pred cccCCCCCCCCCHHHHHHHHccCCCCCCCCCCccccccccccchHHHHHHHHHHHHHHHHhcccHHHhcceeeeccCC Confidence 999999999999999999999999999999999999999999999999999999999999999999999999998764 No 2 >6CS2_B Spike glycoprotein,Envelope glycoprotein, Angiotensin-converting enzyme; membrane fusion, glycoprotein, receptor binding; HET: BMA, MAN, NAG;{Human SARS coronavirus} Probab=100.00 E-value=3.2e-221 Score=1857.50 Aligned_cols=1161 Identities=77% Similarity=1.263 Sum_probs=1101.0 Template_Neff=4.100 Q sp|P0DTC2|SPIK 31 SFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNGTKRFDNPVLPFNDGVYFASTEKSNIIRGWIFGTTL 110 (1273) Q Consensus 31 sftrgvyypdkvfrssvlhstqdlflpffsnvtwfhaihvsgtngtkrfdnpvlpfndgvyfasteksniirgwifgttl 110 (1273) +-.+|+||||..++++...-+|++|.++-++++-+|+. -.-+.+++.||+||+++...+++|.-++|+||+|. T Consensus 22 ~~~~g~yYPd~~~~sN~t~L~qglfp~~gs~~~~~~~~-------~~~y~~~~~~F~dGifv~v~~~~n~~~a~~fGsTF 94 (1215) T 6CS2_B 22 SSMRGVYYPDEIFRSDTLYLTQDLFLPFYSNVTGFHTI-------NHTFGNPVIPFKDGIYFAATEKSNVVRGWVFGSTM 94 (1215) T ss_pred cccceeEecCCeeeccceeeeeCccCCCCCCCccCCcc-------hhhcCCCccccCCcEEEEeeEecCCCCceeeeecc Confidence 45689999999999999999999999999999987776 34577889999999999999999998899999999 Q sp|P0DTC2|SPIK 111 DSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVYYHKNNKSWMESEFRVYSSANNCTFEYVSQPFLMDLEGKQGNFKNLR 190 (1273) Q Consensus 111 dsktqsllivnnatnvvikvcefqfcndpflgvyyhknnkswmesefrvyssannctfeyvsqpflmdlegkqgnfknlr 190 (1273) +..+++++|+++-+...|.+|.|..|..|...+++.-.| -.+++.|..+.||+|.|.|+.|-+|...+-.+....+ T Consensus 95 ~N~s~tvVI~P~~~~~~it~C~~~vC~~p~~~~~p~~gn----~~~~~~~~~~~nc~f~~~~~nfT~d~~~~~~~~~~r~ 170 (1215) T 6CS2_B 95 NNKSQSVIIINNSTNVVIRACNFELCDNPFFAVSKPMGT----QTHTMIFDNAFNCTFEYISDAFSLDVSEKSGNFKHLR 170 (1215) T ss_pred cCCceEEEEcCCCCcceeeEeEEEeCCCCceeEcCCCCC----cccccceeecCCceEEEcccccccccccceeeeeEEE Confidence 999999999999999999999999999999988874443 4678889999999999999999999888888888899 Q sp|P0DTC2|SPIK 191 EFVFKNIDGYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHRSYLTPGDSSSGWTAGAAAYYVGYL 270 (1273) Q Consensus 191 efvfknidgyfkiyskhtpinlvrdlpqgfsaleplvdlpiginitrfqtllalhrsyltpgdsssgwtagaaayyvgyl 270 (1273) +|+|++.||+|-+|-.+.+.+..+.+|.|...|.|..-+|..++|+.|..++ -.|| ++ .+.|+...++|||.+| T Consensus 171 ~f~F~~~~G~fy~Y~a~~~~~~f~~~~~~~~~l~yy~vip~~~~~~~~~~~~-~~~~--~~---~~~~~~~~~~~yv~~L 244 (1215) T 6CS2_B 171 EFVFKNKDGFLYVYKGYQPIDVVRDLPSGFNTLKPIFKLPLGINITNFRAIL-TAFS--PA---QDIWGTSAAAYFVGYL 244 (1215) T ss_pred EEEEEecCCeEEEEeecCCCcccccCCCCcccceeeEeeceecccccceEEe-eecC--CC---CCcccccceEEEEeec Confidence 9999999999999988877777899999999999999999999999998872 2233 22 5677888999999999 Q sp|P0DTC2|SPIK 271 QPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASV 350 (1273) Q Consensus 271 qprtfllkynengtitdavdcaldplsetkctlksftvekgiyqtsnfrvqptesivrfpnitnlcpfgevfnatrfasv 350 (1273) .+|+++|.|..||+|+|++||+-+|.+|-+|.-.+|....|.|..++++++|.-...|.......|+|.+++++.++.++ T Consensus 245 ~~~~~lLayf~NGti~dvIdC~~sp~~~LaCqy~T~nfsdGvYp~s~~~vk~~fiVyr~~~~~~~C~~~~~~~~~~~Psp 324 (1215) T 6CS2_B 245 KPTTFMLKYDENGTITDAVDCSQNPLAELKCSVKSFEIDKGIYQTSNFRVVPSGDVVRFPNITNLCPFGEVFNATKFPSV 324 (1215) T ss_pred eeceeehHHhcCCeEEEEEECCCCcccceeceeceeccCCCeeeccceEeeceEEEEECCCCCCCCCHHHHhhCCCCCCc Confidence 99999999999999999999999999999999999999999999999999999999999988899999999999999999 Q sp|P0DTC2|SPIK 351 YAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFT 430 (1273) Q Consensus 351 yawnrkrisncvadysvlynsasfstfkcygvsptklndlcftnvyadsfvirgdevrqiapgqtgkiadynyklpddft 430 (1273) |.|.|+.++||..|+++|++..++++|+||||||.||.+.||..|++|.|.|..+..++++||++|.|++||||+|+||+ T Consensus 325 ~~w~R~~fsnCnfn~s~Lls~~~~~~f~C~gIspskLa~mCfsSvtiD~F~ip~s~~~~l~~g~~g~i~~~NYkl~~~~~ 404 (1215) T 6CS2_B 325 YAWERKKISNCVADYSVLYNSTFFSTFKCYGVSATKLNDLCFSNVYADSFVVKGDDVRQIAPGQTGVIADYNYKLPDDFM 404 (1215) T ss_pred cceeEeEEecCCCCHHHHHhcceeeeeEeeCCCHHHHcccccCeeeEEEeeccccchhhcCCCCCchHHhcccCCCCCCC Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 431 GCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRV 510 (1273) Q Consensus 431 gcviawnsnnldskvggnynylyrlfrksnlkpferdisteiyqagstpcngvegfncyfplqsygfqptngvgyqpyrv 510 (1273) ||+++|+-.+++..+..++|+.++-.|+..++|+++|.+.--+.-...+|. ..|-.|..++..|.+...-|+|++++++ T Consensus 405 ~C~l~~~~~~~~vn~t~~~n~~~~~~r~~~~~~~~~d~~~CPf~~~~s~C~-~~~~~~~~~i~~~~~~~~~g~~~~~~g~ 483 (1215) T 6CS2_B 405 GCVLAWNTRNIDATSTGNYNYKYRYLRHGKLRPFERDISNVPFSPDGKPCT-PPALNCYWPLNDYGFYTTTGIGYQPYRV 483 (1215) T ss_pred ceEEEEEcCccceeccCCCCcccccccccceeecCCCCCCCCCCCCCCCCC-CCCCCCCcccccccceeeccccceeeEE Confidence 999999988888776667777766666666889999888744444467884 3666777788888765567999999999 Q sp|P0DTC2|SPIK 511 VVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPC 590 (1273) Q Consensus 511 vvlsfellhapatvcgpkkstnlvknkcvnfnfngltgtgvltesnkkflpfqqfgrdiadttdavrdpqtleilditpc 590 (1273) ++++++....|++|||+|..+.++.+.||++|+.|.||+||++|+|..+..+|.|+.|..+-..++||+.|+++..|+|| T Consensus 484 lvis~k~~~~p~tVCg~~~~T~l~ldvCV~YnIYGiTGtGVi~~sn~t~~sgqsf~~ds~GfL~gfKn~ttG~iYsI~PC 563 (1215) T 6CS2_B 484 VVLSFELLNAPATVCGPKLSTDLIKNQCVNFNFNGLTGTGVLTPSSKRFQPFQQFGRDVSDFTDSVRDPKTSEILDISPC 563 (1215) T ss_pred EEEEEEEcCCCCcccCCcCccceeeceeEeEEeCCceeeEEEEecCcEecCCeeeEEeCCcceeEEEeCCCCCEEEEeeC Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 591 SFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEHVNNSYECDIPIGAGI 670 (1273) Q Consensus 591 sfggvsvitpgtntsnqvavlyqdvnctevpvaihadqltptwrvystgsnvfqtragcligaehvnnsyecdipigagi 670 (1273) .++.|||+.+|.++|+..|+||..++|+++....+..+.+|.|+.++++.+.|||-+||++||++.+...+|++|+|.|+ T Consensus 564 ~s~~VSVVy~g~~sS~~~alLf~~v~C~~v~~~~~~~~~~p~~~~~s~~~~~fdT~~GCv~na~n~~~v~~C~lplG~Gl 643 (1215) T 6CS2_B 564 AFGGVSVITPGTNASSEVAVLYQDVNCTDVSTAIHADQLTPAWRIYSTGNNVFQTQAGCLIGAEHVDTSYECDIPIGAGI 643 (1215) T ss_pred eecceEEEEcCCccCCCcceeccccccccccccccceeecCceEEeeCCCCCcccccceeecccCCCcccccCcccccee Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 671 CASYQTQTNSPRRARSVASQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECS 750 (1273) Q Consensus 671 casyqtqtnsprrarsvasqsiiaytmslgaensvaysnnsiaiptnftisvtteilpvsmtktsvdctmyicgdstecs 750 (1273) |+.+.+ .++.|+....++..|+++++....++.+...|.||+||||+|++|-++++|.|.+|||.+|+||++.+|. T Consensus 644 C~d~~~----~~~~~~~~~~~~~~y~~p~~~~s~~~~~~~~i~IP~nft~~v~~Eyiq~~~~kv~idC~~YVC~~~~~C~ 719 (1215) T 6CS2_B 644 CASYHT----VSLLRSTSQKSIVAYTMSLGADSSIAYSNNTIAIPTNFSISITTEVMPVSMAKTSVDCNMYICGDSTECA 719 (1215) T ss_pred ecCCCc----eeeccCCCceeeeeeecCCCCCCCCCceeeEEEccCCeEEEEEEEEeeecCCCeEEechhhccCCCHHHH Confidence 999988 3333335566778999998765578888999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 751 NLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQILPDPSKPSKRSFIEDLLFNKVTLAD 830 (1273) Q Consensus 751 nlllqygsfctqlnraltgiaveqdkntqevfaqvkqiyktppikdfggfnfsqilpdpskpskrsfiedllfnkvtlad 830 (1273) +||.|||+||..+|+||.+.+..+|.+..+++...++-++.|-+..||||||+.+||.++++++||+||||||+||..+| T Consensus 720 ~lL~qYgs~C~~I~~al~~~~~l~d~~~~~~~~~~~~~~~~~~~~~~~~~n~s~~l~~~~~~~~RS~iEDLLF~KV~t~g 799 (1215) T 6CS2_B 720 NLLLQYGSFCTQLNRALSGIAAEQDRNTREVFAQVKQMYKTPTLKYFGGFNFSQILPDPLKPTKRSFIEDLLFNKVTLAD 799 (1215) T ss_pred HHHHHHHHHHHHHHHHHHHHHhHHhHHHHHHHHhcccCCCCCcccccCCccchhcCCCCCCCCCccHHHHHHcCeeeeCC Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 831 AGFIKQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIG 910 (1273) Q Consensus 831 agfikqygdclgdiaardlicaqkfngltvlpplltdemiaqytsallagtitsgwtfgagaalqipfamqmayrfngig 910 (1273) .|+.+.|.+|.+...+|||+|||.+||+.||||++++||++.||++|++|....|||||+|+|..|||||||.||+||+| T Consensus 800 ~g~~~~Y~~C~~g~~i~DL~CaQ~ynGi~VLP~v~~~~~~a~YT~sl~g~ma~gg~T~g~~sa~aiPFa~~vq~RlN~v~ 879 (1215) T 6CS2_B 800 AGFMKQYGECLGDINARDLICAQKFNGLTVLPPLLTDDMIAAYTAALVSGTATAGWTFGAGAALQIPFAMQMAYRFNGIG 879 (1215) T ss_pred CCchhhHhhccCCccHHHHhcccccCeEEEeCCCCCHHHHHHHHHHHHHHHHhccccccccccccccHHHHHHHHhchhh Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 911 VTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAE 990 (1273) Q Consensus 911 vtqnvlyenqklianqfnsaigkiqdslsstasalgklqdvvnqnaqalntlvkqlssnfgaissvlndilsrldkveae 990 (1273) +||+||.||||+|||.||.||+.||+.++.+++||.|+||||||+++||++|++||+.|||||||.++||++|||++||+ T Consensus 880 l~~~vL~~NQk~iA~sFN~A~~~i~~g~~t~~~Al~kiQ~VVN~~~~aL~~L~~qL~~nFgAISssi~dIy~RLd~leAd 959 (1215) T 6CS2_B 880 VTQNVLYENQKQIANQFNKAISQIQESLTTTSTALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDPPEAE 959 (1215) T ss_pred ccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhhHHHHHHHHHHHHHHHHHHH Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 991 VQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPA 1070 (1273) Q Consensus 991 vqidrlitgrlqslqtyvtqqliraaeirasanlaatkmsecvlgqskrvdfcgkgyhlmsfpqsaphgvvflhvtyvpa 1070 (1273) +||||||+|||.+|++||+|+|+|++|+|+|+.||..|+.|||..||+|.+|||.|.|++|+||.||+|++|+|.+|+|. T Consensus 960 aQvDRLItGRL~aLna~vtq~l~~~~~v~~sr~lA~qKinECVksQS~R~gFCGnG~Hi~S~~q~AP~Gi~F~H~~~~Pt 1039 (1215) T 6CS2_B 960 VQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQAAPHGVVFLHVTYVPS 1039 (1215) T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhcccCcCCCCCCeeeEeecccCCCeEEEEEEeeccc Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 1071 QEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDSFKE 1150 (1273) Q Consensus 1071 qeknfttapaichdgkahfpregvfvsngthwfvtqrnfyepqiittdntfvsgncdvvigivnntvydplqpeldsfke 1150 (1273) +.++.+++|.+|+++++..|++|+|+.|++.|++|.|++|||..||.+|...-..|||....+|+++.+|++|++..|+| T Consensus 1040 ~~~~v~a~~GlC~~~~~~~~~~g~f~~~~~~~~~T~r~~y~P~~~t~~d~v~i~sC~V~y~nvn~~~~~~~~p~~~df~~ 1119 (1215) T 6CS2_B 1040 QERNFTTAPAICHEGKAYFPREGVFVFNGTSWFITQRNFFSPQIITTDNTFVSGNCDVVIGIINNTVYDPLQPELDSFKE 1119 (1215) T ss_pred ceeEEEEEceeeeCCCceeecceEEEEcCcEEEEeccccccCCCCChhceEEeecCceeEEeecCCCCCCCCCCCCCHHH Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 1151 ELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIKWP 1213 (1273) Q Consensus 1151 eldkyfknhtspdvdlgdisginasvvniqkeidrlnevaknlneslidlqelgkyeqyikwp 1213 (1273) ||++|+||||+|+.+++++..+|++++|++.||++|+|+.|+||+++|||++|++||+|-+|+ T Consensus 1120 el~~~~~N~t~p~~~~~~~~~~N~t~LnLt~EI~~L~~~i~~LN~s~IDLe~L~~~e~ya~~~ 1182 (1215) T 6CS2_B 1120 ELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQGSGYI 1182 (1215) T ss_pred HHHHHhcCCCCCCCCCCChhhccccccchHHHHHHHHHHHHHHHhcCcCHHHhcceeHhhcCC Confidence 999999999999999999999999999999999999999999999999999999999998875 No 3 >6Q04_B Spike glycoprotein; Coronavirus, spike glycoprotein, MERS-CoV, membrane; HET: MAN, SIA, NAG, FOL, BMA; 2.5A {Human betacoronavirus 2c EMC/2012} Probab=100.00 E-value=1.8e-204 Score=1723.92 Aligned_cols=1150 Identities=31% Similarity=0.496 Sum_probs=897.1 Template_Neff=3.700 Q sp|P0DTC2|SPIK 31 SFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNG--T-------KRFDNPVLPFNDGVYFASTEKSNII 101 (1273) Q Consensus 31 sftrgvyypdkvfrssvlhstqdlflpffsnvtwfhaihvsgtng--t-------krfdnpvlpfndgvyfasteksnii 101 (1273) +-.+|+||||..++++..+-.|++|.+.-++.+-.- ++|++. + -.++.+..||+||+++...+.+|-- T Consensus 65 s~~~G~yYPd~rvysN~TlL~qglfP~~gs~~~~y~---~~~t~~~s~~~~~~~~~~y~~~~~~F~dGifvkv~~~~n~t 141 (1359) T 6Q04_B 65 SKADGIIYPQGRTYSNITITYQGLFPYQGDHGDMYV---YSAGHATGTTPQKLFVANYSQDVKQFANGFVVRIGAAANST 141 (1359) T ss_dssp GGTTTCBCCTTCEECSEEEEEEEEECCTTCCCEEEC---CEECCEETTEECSEEECSCTTCCEECTTCEEEEESTTTTSE T ss_pred ccCceeEeeCCeeEeeeeeeeeceecCCCCcceEEE---EEecCCCCCCCcceeeeccCCChhhccCeEEEEEeeeecCC Confidence 346899999999999999999999999988876542 333332 1 3567789999999999888766643 Q sp|P0DTC2|SPIK 102 R-----------------GWIFGTTLDSKT---Q------SLLIVNNATNVVI-------KVCEFQFCNDPFLGVYYHKN 148 (1273) Q Consensus 102 r-----------------gwifgttldskt---q------sllivnnatnvvi-------kvcefqfcndpflgvyyhkn 148 (1273) . .++||+|.+... + +++|+++-.+.++ ...+..-|..|..-+++.-+ T Consensus 142 g~~~~~~~~~~~~~~~ypa~~fGsTF~Nts~~~~~~~~~~tlVI~P~~~g~~~~~~~c~~~prtit~C~~p~~~~~p~~~ 221 (1359) T 6Q04_B 142 GTVIISPSTSATIRKIYPAFMLGSSVGNFSDGKMGRFFNHTLVLLPDGCGTLLRAFYCILEPRSGNHCPAGNSYTSFATY 221 (1359) T ss_dssp EEETTEEEEEEEEECCCCCEEEESCEEECTTSCEEEECSEEEEEEEETTTTEEEEEEEEEEECCSBTSTTSSSCCCCCEE T ss_pred CCeeeCCccccchhhhccceEeeccccCCCCCccccccceEEEEecCCCCchheeeeecccccccCcCCCCCeEeeeeec Confidence 2 256999998666 5 8899988887543 32333345555555554222 Q sp|P0DTC2|SPIK 149 N---KSWMES---------EFRVYSSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVFKNID-GYFKIYSKHTPINL--- 212 (1273) Q Consensus 149 n---kswmes---------efrvyssannctfeyvsqpflmdlegkqgnfknlrefvfknid-gyfkiyskhtpinl--- 212 (1273) . .+|..+ +++.|....+|+|.|. +.|-+|... ..|- |.|+..| |.|-+|.-++..+. T Consensus 222 ~~~~~~~~~~~~~~n~~~~~~~~~~~~~~~~~~~~-~nfT~d~~~--~wf~----~~F~~~~~G~f~~Y~~d~~~~~~f~ 294 (1359) T 6Q04_B 222 HTPATDCSDGNYNRNASLNSFKEYFNLRNCTFMYT-YNITEDEIL--EWFG----ITQTAQGVHLFSSRYVDLYGGNMFQ 294 (1359) T ss_dssp ECHHHHBCSSCBCTTHHHHHHHHHEEEEEEEEEEE-EECCCCCCC--EEEE----EEEETTEEEEEESTTTCTTTCCBEE T ss_pred CCCCccCCCCcccccccccchhHhcccCCceEEEe-eecCcchhh--heee----EEeeecCceeEEEEEEecCCCccee Confidence 1 245333 6778889999999875 344333211 1121 9999999 99999876654432 Q sp|P0DTC2|SPIK 213 VRDLPQGFSALEPLVDLPIGINITRFQTLLALHRSYLTPGDSSSGWTAGAAAYYVGYLQPRTFLLKYNENGTITDAVDCA 292 (1273) Q Consensus 213 vrdlpqgfsaleplvdlpiginitrfqtllalhrsyltpgdsssgwtagaaayyvgylqprtfllkynengtitdavdca 292 (1273) ..-+| |+..+.+.. .+-|+..++ .+.+. ..++|||++|.+|+|||+|++||.|++||||+ T Consensus 295 f~~~~-~~~~~~yy~---------------v~p~~~~~~---~~~~~-~~~~~yv~~L~~~~~Ll~fd~nG~I~~avDC~ 354 (1359) T 6Q04_B 295 FATLP-VYDTIKYYS---------------IIPHSIRSI---QSDRK-AWAAFYVYKLQPLTFLLDFSVDGYIRRAIDCG 354 (1359) T ss_dssp EEEEC-CCSCCCEEE---------------ECCEEECCC---GGGCC-EECCEEEEECEEEEEEEEECTTSCEEEEEETT T ss_pred ccccc-ceeccceee---------------eeeeeecCC---ccccc-eeEEEEEEEccceeEEEeecCCCeEEEEEecC Confidence 12222 444444443 233444444 34455 77899999999999999999999999999999 Q sp|P0DTC2|SPIK 293 LDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSA 372 (1273) Q Consensus 293 ldplsetkctlksftvekgiyqtsnfrvqptesivrfpnitnlcpfgevfnatrfasvyawnrkrisncvadysvlynsa 372 (1273) -|+++|-||..+||.+++|+|++|+||+||....+|.++. ..|+|.++++ .++.++|.|.|+.++||..|+|+|++.. T Consensus 355 ~~~~sEL~C~~~sf~~~tGVY~~S~y~aqp~~~v~~~~~~-~~C~~~~~~~-~~~P~p~~w~R~~f~nCnfN~s~Lls~~ 432 (1359) T 6Q04_B 355 FNDLSQLHCSYESFDVESGVYSVSSFEAKPSGSVVEQAEG-VECDFSPLLS-GTPPQVYNFKRLVFTNCNYNLTKLLSLF 432 (1359) T ss_dssp SCHHHHHHHHTTSSCCCSEEEEEEEECCCCSCEEEECCCS-CBCCCGGGGS-BCCCBGGGCEEEEECSEEECHHHHHTTS T ss_pred CCccchheeEeceecCCCCeeecCCEEEEeeeEEEEecCC-CCCCchHHhc-CCCCCcceeEEeEEecCCCcHHHHHhhc Confidence 9999999999999999999999999999999999999999 9999999999 8899999999999999999999999999 Q sp|P0DTC2|SPIK 373 SFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKV--GGNYN 450 (1273) Q Consensus 373 sfstfkcygvsptklndlcftnvyadsfvirgdevrqiapgqtgkiadynyklpddftgcviawnsnnldskv--ggnyn 450 (1273) .+++|+||||+|.||.+.||..|++|.|.|..+..++++||++|-|++||||+|+||+||+++|+-...+..+ -.+|+ T Consensus 433 ~~~sF~C~gIspskLa~mCfsSvtiD~Faip~~~k~~Lq~G~~G~i~~yNYKld~~~~gC~l~y~~pa~~vn~t~p~~y~ 512 (1359) T 6Q04_B 433 SVNDFTCSQISPAAIASNCYSSLILDYFSYPLSMKSDLSVSSAGPISQFNYKQSFSNPTCLILATVPHNLTTITKPLKYS 512 (1359) T ss_dssp EEEEEEEESSCHHHHTTCCBSEEEEEEEECCGGGGGGGSTTBCSHCCCCCCCCCSSSCEEEEEEECCTTCTTBCCCSEEE T ss_pred eeeeeeecCCCHHHHcccccceeeEEEEecCccccceecCCCCChhhhccccCCCCCCccEEEEEcCccccccCCCccce Confidence 9999999999999999999999999999999999999999999999999999999999999999955533322 44555 Q sp|P0DTC2|SPIK 451 YLYRLFRKSNLKPFERDISTEI---YQAGSTPCNGV-EGFNCYFPLQSY-----------GFQP----TNGVGYQPYRVV 511 (1273) Q Consensus 451 ylyrlfrksnlkpferdistei---yqagstpcngv-egfncyfplqsy-----------gfqp----tngvgyqpyrvv 511 (1273) |+.|-+++.. ++. ++. ..+ .+-|+-. ...+|+.|...+ |..| ..++++|++.++ T Consensus 513 yi~~~~~~~~-----~~~-~~~~~~~~~-~~~cpc~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~g~~ 585 (1359) T 6Q04_B 513 YINKCSRLLS-----DDR-TEVPQLVNA-NQYSPCVSIVPSTVWEDGDYYRKQLSPLEGGGWLVASGSTVAMTEQLQMGF 585 (1359) T ss_dssp EEEEEEEECT-----TSS-CEEECCCCT-TSCCGGGGTSCSSCSSTTCEEEEECCGGGTSSEEEEEEEEEECCSSCEEEE T ss_pred eeeeeeccCC-----CCC-Ccchhhccc-cccCCCCccCCccccCCCCccccccccccCCchhcccccccccccceeEEE Confidence 5555555333 222 222 111 1112100 112455543322 2333 458999999999 Q sp|P0DTC2|SPIK 512 VLSFELLHAPATVCGP-----KKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILD 586 (1273) Q Consensus 512 vlsfellhapatvcgp-----kkstnlvknkcvnfnfngltgtgvltesnkkflpfqqfgrdiadttdavrdpqtleild 586 (1273) |++++..+.++|||++ |.+|.++.++||++++.|+||+||++|+++.+.++|+|..|-.+-..++|| +++++.+ T Consensus 586 Vis~k~~~~s~tVCp~~~d~~~~~T~~~lg~CVnY~LYGiTGtGVf~~s~~~~~s~Q~f~yDs~Gnl~gf~d-~tn~~Y~ 664 (1359) T 6Q04_B 586 GITVQYGTDTNSVCPKLEFANDTKIASQLGNCVEYSLYGVSGRGVFQNCTAVGVRQQRFVYDAYQNLVGYYS-DDGNYYC 664 (1359) T ss_dssp EEEEESSSSCCCEEECCCCCTTSCSGGGTTSEEEEEETTEEEEEEEEECCCCSCGGGCEEECTTSCEEEEEC-TTSCEEE T ss_pred EEEeEcCCCcCccCCCccccCCCCcchhcCceeEEEecceeeeeEEEecCceeecceeeEEeCCCCEEEEEe-CCCCEEE Confidence 9999999999999998 667999999999999999999999999999999999999999999999999 8999999 Q sp|P0DTC2|SPIK 587 ITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRV--YSTGSNVFQTRAGCLIGAEHVNN-SYECD 663 (1273) Q Consensus 587 itpcsfggvsvitpgtntsnqvavlyqdvnctevpvaihadqltptwrv--ystgsnvfqtragcligaehvnn-syecd 663 (1273) |.||..|+|||+++++ ++.+|+||++++|.+|+...+..+.+|.||+ +++..+.|||-+||++||++.+. .+||| T Consensus 665 I~PC~sg~VSV~y~~~--s~e~AlLf~~l~C~~v~~~~~~~~~~~~~~l~~~~~~~~~fdT~~GCVvnA~n~t~~V~~C~ 742 (1359) T 6Q04_B 665 LRACVSVPVSVIYDKE--TKTHATLFGSVACEHISSTMSQYSRSTRSMLKRRDSTYGPLQTPVGCVLGLVNSSLFVEDCK 742 (1359) T ss_dssp EECCCCEEEEEEEETT--TTEEEEEEETCCGGGC---------------------CCCEEETTEEEESEEEEEEEESSCS T ss_pred EeeceEEeeeEEEcCC--CCCeEEEEccccccHhhcceeeccCCCccccccccCCCCCCCCccceeeeceecCCceeeCC Confidence 9999999999999998 8999999999999999999999999999998 77788999999999999999988 89999 Q sp|P0DTC2|SPIK 664 IPIGAGICASYQTQTNSPR-RARSVAS-QSII--AYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCT 739 (1273) Q Consensus 664 ipigagicasyqtqtnspr-rarsvas-qsii--aytmslgaensvaysnnsiaiptnftisvtteilpvsmtktsvdct 739 (1273) +|+|.|+|+.|.+...+.| +.|++.. ..+. +|+|.+-. .++.+++..|.||+||||+|++|-++++|.|.+|||. T Consensus 743 LplG~glC~~y~~~s~~~~r~~~~~~~~~~l~~~~y~~P~~~-~~~~~~~~~i~IP~nFt~~v~~EyiQ~~~~kv~iDC~ 821 (1359) T 6Q04_B 743 LPLGQSLCALPDTPSTLTPASVGSVPGEMRLASIAFNHPIQV-DQLNSSYFKLSIPTNFSFGVTQEYIQTTIQKVTVDCK 821 (1359) T ss_dssp SEEETTEEEECCCC------------CCEEEEEECCCCCEEC-CCCSSSCEEEEECSEEEEEEEEEEEECCCCEEEECHH T ss_pred CCCCceeecCCCCCCCCCCcccCCCCCceEEEEEeecCCeee-cccCCCCeeEEcccceEEEEEEEEEeecCCceEEech Confidence 9999999999998774433 3343333 3344 77787766 7888999999999999999999999999999999999 Q sp|P0DTC2|SPIK 740 MYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDF-GGFNFSQILPDPS---KPSKR 815 (1273) Q Consensus 740 myicgdstecsnlllqygsfctqlnraltgiaveqdkntqevfaqvkqiyktppikdf-ggfnfsqilpdps---kpskr 815 (1273) +|+||++.+|.+||.|||+||..+|+||.|.+.++|.+..+++..+++-++.+-+..| |+|||+.+||... ++++| T Consensus 822 ~YVC~~~~~C~~lL~qYgs~C~~I~~aL~~~~~~~d~~~~~~~~~~~~~~~~~~~~~f~~~~N~s~ll~~~~~~~~~~~R 901 (1359) T 6Q04_B 822 QYVCNGFQKCEQLLREYGQFCSKINQALHGANLRQDDSVRNLFASVKSSQSSPIIPGFGGDFNLTLLEPVSISTGSRSAR 901 (1359) T ss_dssp HHHHTTCHHHHHHHGGGCSHHHHHHHHHHHHHHHHHHHHHHHHHHHCCSEECCCCTTTTTTSCCTTTSBC--------CC T ss_pred hhccCCCHHHHHHHHHHHHHHHHHHHHHHHHHhhccHHHHHHHHhccccccCCCcCCCCCCcccceeccCCCCCCCccce Confidence 9999999999999999999999999999999999999999999999999998888887 5799999999875 34689 Q sp|P0DTC2|SPIK 816 SFIEDLLFNKVTLADAGFIKQYGDCLGDI--AARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAA 893 (1273) Q Consensus 816 sfiedllfnkvtladagfikqygdclgdi--aardlicaqkfngltvlpplltdemiaqytsallagtitsgwtfgagaa 893 (1273) |+||||||+||.+.+.||...|+.|.... ..+||+|||.+||+.||||..++||.++|+.+++.+....||++|..++ T Consensus 902 S~ieDLLF~Kv~~~~~G~~~~y~~c~~g~~~~i~Dl~caq~~NGi~VLP~v~~~~le~~Yt~SdvG~l~~~r~e~G~tsa 981 (1359) T 6Q04_B 902 SAIEDLLFDKVTIADPGYMQGYDDCMQQGPASARDLICAQYVAGYKVLPPLMDVNMEAAYTSSLLGSIAGVGWTAGLSSF 981 (1359) T ss_dssp BHHHHHHHHTSCCCCCCTTTHHHHHHHTCCSSTTCTTTTHHHHTEEEECCSSCHHHHHHHHHHHHTTHHHHSSSSSSSCE T ss_pred eHHHHHhcceeeeCCCCcccChhhhcccCCccHHHHhheeEeCCEeecCCccCHHHHHHHHHHHHHhhhcccccccCCcc Confidence 99999999999999999999999999555 8999999999999999999999999999999999988888999999999 Q sp|P0DTC2|SPIK 894 LQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAI 973 (1273) Q Consensus 894 lqipfamqmayrfngigvtqnvlyenqklianqfnsaigkiqdslsstasalgklqdvvnqnaqalntlvkqlssnfgai 973 (1273) ..|||++++.+|+|+++++|++|.+|||.|||.||.|||.||+.+.++++||.|+|++||+++++|++|..||+.||||| T Consensus 982 aaIpfs~~Vy~RLN~l~~~~~vL~~nq~~Ia~sFN~AI~~iq~Gf~t~~~Al~kIq~vVN~~~~aLs~L~~qLn~nFgAI 1061 (1359) T 6Q04_B 982 AAIPFAQSIFYRLNGVGITQQVLSENQKLIANKFNQALGAMQTGFTTTNEAFQKVQDAVNNNAQALSKLASELSNTFGAI 1061 (1359) T ss_dssp EECCHHHHHHHHHHTTTCCHHHHHHTHHHHHHHHHHHHHTTTTCCSTTCHHHHHHHHHHHHHHHHHHHHHHHTTCCTTSS T ss_pred ccCCchHHHHHHHHhhhchHHHHHHHHHHHHHHHHHHHHHHhhccccHHHHHHHHHHHHHHHHHHHHHHHHHHhhhcccc Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 974 SSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFP 1053 (1273) Q Consensus 974 ssvlndilsrldkveaevqidrlitgrlqslqtyvtqqliraaeirasanlaatkmsecvlgqskrvdfcgkgyhlmsfp 1053 (1273) ||.+++|+.|||++||++|+||||+|||.+|++||+|||+|++|+|+|+.||..|+.|||..||+|.+|||.|.|++|+| T Consensus 1062 Sssi~gI~~RLd~lEA~iqvdrlInGRL~aLnafVtq~l~~~~~v~~sr~LA~qKiNECVKSQS~R~gFCGnGtHi~S~~ 1141 (1359) T 6Q04_B 1062 SASIGDIIQRLDPPEQDAQIDRLINGRLTTLNAFVAQQLVRSESAALSAQLAKDKVNECVKAQSKRSGFCGQGTHIVSFV 1141 (1359) T ss_dssp CSCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCSSCCCSTTTSSSSEEEEEEE T ss_pred hhcHhHHHHhcchHHHHhCCChhhhcHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhcccccCCCCCCeeEEEEe Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 1054 QSAPHGVVFLHVTYVPAQEKNFTTAPAICHD---GKAHFPREGVFVSNG-----THWFVTQRNFYEPQIITTDNTFVSGN 1125 (1273) Q Consensus 1054 qsaphgvvflhvtyvpaqeknfttapaichd---gkahfpregvfvsng-----thwfvtqrnfyepqiittdntfvsgn 1125 (1273) |.||+|++|+|++|+|.+.++.+++|.+|++ +++..|+.|.|+.+. .+|++|.|++|||..||.+|+. --. T Consensus 1142 q~AP~Gi~F~H~~~~Pt~~~~V~a~~GlC~~~~~~~~~~p~~g~~v~~~~~~~~~~~~~T~r~~y~P~~~t~~dv~-i~s 1220 (1359) T 6Q04_B 1142 VNAPNGLYFMHVGYYPSNHIEVVSAYGLCDAANPTNCIAPVNGYFIKTNNTRIVDEWSYTGSSFYAPEPITSLNTK-YVA 1220 (1359) T ss_dssp EEETTEEEEEEEEEEEESCEEEEEESCEEESSSTTCEEEESSEEEEEC-------CEEEEETTEEEEECCCTTSEE-EEC T ss_pred eccCCeEEEEEEEeccCceeEEEEEeEEecCCCCCceeeccCeEEEEeCCceeeceEEEeCCccccCccCCccCEE-EEC Confidence 9999999999999999999999999999996 689999999999876 5799999999999999999955 577 Q sp|P0DTC2|SPIK 1126 CDVVIGIVNNTVYDPL--QPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQEL 1203 (1273) Q Consensus 1126 cdvvigivnntvydpl--qpeldsfkeeldkyfknhtspdvdlgdisginasvvniqkeidrlnevaknlneslidlqel 1203 (1273) |||....+|+++..|+ +|+...|+|||+|+|||+++...|+.+++.+|++++|++.||++|+|+.|+||+++|||++| T Consensus 1221 c~V~y~n~~~~~l~~~v~~pdyiDf~~el~~~~~n~~~~~p~l~~l~~~N~T~LNLt~EI~~Lq~~i~~LN~s~idLe~L 1300 (1359) T 6Q04_B 1221 PQVTYQNISTNLPPPLLGNSTGIDFQDELDEFFKNVSTSIPNFGSLTQINTTLLDLTYEMLSLQQVVKALNESYIDLKEL 1300 (1359) T ss_dssp CCTTSEEECSSCCTTTCC-------------------------------------------------------------- T ss_pred CcceeEecCCCCCCCccCCCCCCChHHHHHHHHhcCCCCCCCCCccccceeeecchHHHHHHHHHHHHHHHhcCCCHHHh Confidence 8999999999999984 67999999999999999999888888899999999999999999999999999999999999 Q sp|P0DTC2|SPIK 1204 GKYEQYIKWPWYIWLGFIAGL 1224 (1273) Q Consensus 1204 gkyeqyikwpwyiwlgfiagl 1224 (1273) ++||+||||||||||||-.|- T Consensus 1301 n~~e~YiKWPWYvWL~~~~~~ 1321 (1359) T 6Q04_B 1301 GNYTYYNKGSGRENLYFQGGG 1321 (1359) T ss_dssp --------------------- T ss_pred CceeEEeccCchhheeecCCC Confidence 999999999999999998763 No 4 >5I08_C Spike glycoprotein; coronavirus, glycoprotein, prefusion, VIRAL PROTEIN; 4.04A {Human coronavirus HKU1 (isolate N5)} Probab=100.00 E-value=1.5e-199 Score=1685.13 Aligned_cols=1142 Identities=29% Similarity=0.491 Sum_probs=772.9 Template_Neff=4.000 Q sp|P0DTC2|SPIK 30 NSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNG---TKRFDNPVLPFNDGVYFASTEKSNI------ 100 (1273) Q Consensus 30 nsftrgvyypdkvfrssvlhstqdlflpffsnvtwfhaihvsgtng---tkrfdnpvlpfndgvyfasteksni------ 100 (1273) -+-.+|+||||..++++..+-.|+||.+.-++.+-.- .+|++- --.++++..||+||+++...+.+|- T Consensus 29 vs~~~G~yYPd~rvysN~TlL~qglfp~~gs~~~~y~---~~~t~~~~~~~~y~~~~~~F~dGifvkv~~~~n~t~~~~~ 105 (1299) T 5I08_C 29 VSLGLGTYYVLNRVYLNTTLLFTGYFPKSGANFRDLA---LKGSIYLSTLWYKPPFLSDFNNGIFSKVKNTKLYVNNTLY 105 (1299) T ss_dssp TTSSSSCBCCTTEECCSEEEEEEEEECCTTCEEEECC---CBCSSCEEGGGGSTTTEEECSSEEEEEEECCCEESSSCEE T ss_pred cccceeEEEecceEEeceeeeeeCeecCCCCceeeee---eecccccccceecCCCcccccCcEEEEeeecccCCCCccc Confidence 3556899999999999999999999999988876542 233332 3467888999999999998887764 Q sp|P0DTC2|SPIK 101 --IRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVYYHKNNKSWMESEFRVYSSANNCTFEYVSQPFLMD 178 (1273) Q Consensus 101 --irgwifgttldsktqsllivnnatnvvikvcefqfcndpflgvyyhknnkswmesefrvyssannctfeyvsqpflmd 178 (1273) -..++||+|.+...++++|+++-+...|.+|.|..|..|.+.+++ |..+.. +++. ....+|+|.|. +.|-+| T Consensus 106 ~~~pa~~fGsTF~N~s~tvVI~P~~~~~~it~C~~~vC~~p~~~~~p--~~~~~~--~~~~-~d~~~~~~~~~-~nfT~d 179 (1299) T 5I08_C 106 SEFSTIVIGSVFVNTSYTIVVQPHNGILEITACQYTMCEYPHTVCKS--KGSIRN--ESWH-IDSSEPLCLFK-KNFTYN 179 (1299) T ss_dssp CCCCCEEEESSCSTTSCEEEEEEETTEEEEEEECCCCCSSCCBCCSS--SCCSCC--CTTS-TTCSCCCEEEE-EEEECC T ss_pred eecceeEEeccccCCcEEEEEeCCCceEEEEEEEEEecCCCceEEec--CCCccc--eeee-EeCCCCeEEEe-eccccc Confidence 356789999999999999999999999999999999999987776 332222 3334 56778888653 444343 Q sp|P0DTC2|SPIK 179 LEGKQGNFKNLREFVFKNIDGYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHRSYLTPGDSSSGW 258 (1273) Q Consensus 179 legkqgnfknlrefvfknidgyfkiyskhtpinlvrdlpqgfsaleplvdlpiginitrfqtllalhrsyltpgdsssgw 258 (1273) ... ..| .|.|++.||.|-+|..+...+ ..| +...++|...+.+- .+-|+..++ ++.+ T Consensus 180 ~~~--~~~----~f~F~~~dG~f~~Yyad~~~~------~~f-----~f~~~~~~~~~~yy---vip~~~~~~---~~~~ 236 (1299) T 5I08_C 180 VSA--DWL----YFHFYQERGVFYAYYADVGMP------TTF-----LFSLYLGTILSHYY---VMPLTCNAI---SSNT 236 (1299) T ss_dssp TTC--SEE----EEEEEEETTEEEEEEESSCSS------BEE-----EEEEECCSCCCEEE---ECCBCSTTS---SSSG T ss_pred ccc--eee----EEEEEEeCCEEEEEEeccCCC------cce-----eecccceeecceee---eceeeccCC---CCCC Confidence 322 111 299999999998875543222 111 11111232222222 333444444 5667 Q sp|P0DTC2|SPIK 259 TAGAAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPF 338 (1273) Q Consensus 259 tagaaayyvgylqprtfllkynengtitdavdcaldplsetkctlksftvekgiyqtsnfrvqptesivrfpnitnlcpf 338 (1273) ....++|||++|.+|+|||+|+.||.|++||||+-|+++|-||..+||.+++|+|++|+||+||...++|.+.....|+| T Consensus 237 ~~~~~~~~v~~L~~~~~Ll~fd~~G~It~AvDC~~~~~sEL~C~t~Sf~~~tGVY~lS~y~aqP~~~V~~~~~~~~~C~~ 316 (1299) T 5I08_C 237 DNETLEYWVTPLSRRQYLLNFDEHGVITNAVDCSSSFLSEIQCKTQSFAPNTGVYDLSGFTVKPVATVYRRIPNLPDCDI 316 (1299) T ss_dssp GGCCCCEEEEECEEEEEEEEECTTCCEEEEECGGGCHHHHHHHHHTSSSCCSCEEEEC--------CEEECCSSCCCCCH T ss_pred CccceeEEEeecccceEEEEeCCCCeEeEEEecccCcchhheeeecccCCCCCeeecCCeEEEeeeEEEEecCCCCCCCH Confidence 78889999999999999999999999999999999999999999999999999999999999999999999999899999 Q sp|P0DTC2|SPIK 339 GEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKI 418 (1273) Q Consensus 339 gevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptklndlcftnvyadsfvirgdevrqiapgqtgki 418 (1273) .+++++.++.++|.|.|+.++||..|+++|++..++++|+|||+||.||.+.||..|++|.|.|..+..++++||++|-| T Consensus 317 ~~~~~~~~~P~p~~w~R~~f~nCnfn~s~Lls~~~~~~f~C~~ispskl~~mCfsSvtiD~Faip~s~~~~L~~g~~g~i 396 (1299) T 5I08_C 317 DNWLNNVSVPSPLNWERRIFSNCNFNLSTLLRLVHVDSFSCNNLDKSKIFGSCFNSITVDKFAIPNRRRDDLQLGSSGFL 396 (1299) T ss_dssp HHHHTCSEEECGGGCEEEEECSCEECHHHHHHTSEEEEEEEESSCHHHHHHCCCSCEEEEEEECCSTTGGGGSSSCCSSC T ss_pred HHHhhCCCCCCccceEEeEEecCCCCHHHHHhhceeeeeeeeCCCHHHhcccccCeeEEEEEeccCcchHhcCCCCCcHh Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 419 ADYNYKLPDDFTGCVIAWNSNNLDSKV----GGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCN------------- 481 (1273) Q Consensus 419 adynyklpddftgcviawnsnnldskv----ggnynylyrlfrksnlkpferdisteiyqagstpcn------------- 481 (1273) ++||||+|++|+||+++|+-.+.+..+ -++||.-|+. +..++++.++..+..-..++++-|. T Consensus 397 ~~~NYkl~~~~~sC~l~~~~~~~~vt~t~~nps~~n~ry~~-~~~~~~~hdv~Ys~~cf~~~~~~cPC~~p~~~~~~~~~ 475 (1299) T 5I08_C 397 QSSNYKIDISSSSCQLYYSLPLVNVTINNFNPSSWNRRYGF-GSFNLSSYDVVYSDHCFSVNSDFCPCADPSVVNSCAKS 475 (1299) T ss_dssp CCCCCCCCCSSSEEEEEEEEESSSCEEECCCCSCCTTTCCC-CCCSSEEECCCSCCCCCTTCCCCCCC------------ T ss_pred HhccccCCCCCCceEEEEEcccccceecCCCcccchhccCc-cccCCCccceeeeccccccCCCCCCCCChhhcccCcCC Confidence 999999999999999999966655444 3567766665 6667888888888777766655443 Q sp|P0DTC2|SPIK 482 --------------------------------GVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFEL------------ 517 (1273) Q Consensus 482 --------------------------------gvegfncyfplqsygfqptngvgyqpyrvvvlsfel------------ 517 (1273) +..+..|+-+...+.....-|+|++.+++.|++.+. T Consensus 476 ~~~~~~~~~~t~~r~c~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~q~~~~vg~g~~c~g~~V~~~k~g~~~~~~~c~c~ 555 (1299) T 5I08_C 476 KPPSAICPAGTKYRHCDLDTTLYVKNWCRCSCLPDPISTYSPNTCPQKKVVVGIGEHCPGLGINEEKCGTQLNHSSCFCS 555 (1299) T ss_dssp -------------------------------------------------------------------------------- T ss_pred CCCCCCCCCCCcceecccccccccccccccccCCCCCCccCCCCCCCceeeeecccccCeeEEEeeecCCCCCCCCcccC Confidence 111344554554444455679999999999999888 Q sp|P0DTC2|SPIK 518 ---------------------------LHAPATVCGP---KKSTNLVKNKCVNFNFNGLTGTGVLTE-SNKKFLPFQQFG 566 (1273) Q Consensus 518 ---------------------------lhapatvcgp---kkstnlvknkcvnfnfngltgtgvlte-snkkflpfqqfg 566 (1273) ...++|+|+. +.+++++.++||++|..|.||+||+++ ++..++.+|.+. T Consensus 556 ~~af~gws~dsc~~~~~~~~~~~~~~~~~~t~Tvcp~~~~~~~snI~Ln~CVdYNIYG~TGtGVItnvt~s~~~~~qGL~ 635 (1299) T 5I08_C 556 PDAFLGWSFDSCISNNRCNIFSNFIFNGINSGTTCSNDLLYSNTEISTGVCVNYDLYGITGQGIFKEVSAAYYNNWQNLL 635 (1299) T ss_dssp ---CCSCCEEECCBTTEEEEEEEEEESSSSSSSCEECTTCCCCCCCCCSSSEEEEETTEEEEEEEEECCCCCCCTTTCEE T ss_pred ccccccccccccccCCccccccceeccCCCCCCcCCCccccCCceeEeCeeEeEEeCCCeeEEEEEeCCCceeecCCcEE Confidence 5668999998 467899999999999999999999999 444467788888 Q sp|P0DTC2|SPIK 567 RDIADTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTR 646 (1273) Q Consensus 567 rdiadttdavrdpqtleilditpcsfggvsvitpgtntsnqvavlyqdvnctevpvaihadqltptwrvystgsnvfqtr 646 (1273) .|-+.-..++|++.++++..|+||..+.++++..|. +...+.+++.++|.++..... +....+-|+|. T Consensus 636 ydssGdLlgFKn~ttg~iYsV~PC~~v~vqvVv~~~--~~vgall~~n~~cs~~~~n~~----------~~~~~~~~~t~ 703 (1299) T 5I08_C 636 YDSNGNIIGFKDFLTNKTYTILPCYSGRVSAAFYQN--SSSPALLYRNLKCSYVLNNIS----------FISQPFYFDSY 703 (1299) T ss_dssp EETTEEEEEEECTTTCCEEEEECCCCCCEEEECCCC-----CEEEEETCCHHHHHHTC----------------CCEECS T ss_pred EeCCCCEEEEEeCCCCcEEEEEeCcccceEEEEeCC--CcceeEEeecCcccceeecee----------eecCccceecc Confidence 888888889999999999999999999999998876 344689999999988765311 22222559999 Q sp|P0DTC2|SPIK 647 AGCLIGAEHVNN--SYECDIPIGAGICASYQTQTNSPRRARSVAS--QSIIAYTMSL-----GAENSVAYSNNSIAIPTN 717 (1273) Q Consensus 647 agcligaehvnn--syecdipigagicasyqtqtnsprrarsvas--qsiiaytmsl-----gaensvaysnnsiaiptn 717 (1273) .||.+++++... ..+|+.|.|.|+|+.+.+. +++++++..+ .++..| +.. -....+..+...|.||+| T Consensus 704 ~gc~~~~~~~t~~~v~~c~~~~~~~~C~~~~~~--~~~g~~~~~~~~~~l~~~-~p~~~~~~~~~~~~~~~~~~IsIPtN 780 (1299) T 5I08_C 704 LGCVLNAVNLTSYSVSSCDLRMGSGFCIDYALP--SSGGSGSGISSPYRFVTF-EPFNVSFVNDSVETVGGLFEIQIPTN 780 (1299) T ss_dssp SEEESSCBCCCSSBCSSCSCBCSTTEEEEC----------------CCEEEEC-CCCC---------------------C T ss_pred cceeeeceeccCCccccCccccCCceeeecCCC--CCCCCCCCcCCCeeeeEe-cceeeeecCCcccccceEEEEEccCC Confidence 999999976644 7789999999999999877 5555554332 234443 221 011124445558999999 Q sp|P0DTC2|SPIK 718 FTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTP-P--- 793 (1273) Q Consensus 718 ftisvtteilpvsmtktsvdctmyicgdstecsnlllqygsfctqlnraltgiaveqdkntqevfaqvkqiyktp-p--- 793 (1273) |||+|++|-++++|.|.+|||.+|+||++.+|.+||.|||+||..+++||.|.+..+|....+++..+++-++++ + T Consensus 781 FTisv~~EyiQt~~~kVsVDCa~YVCngn~~C~~lL~qYgs~C~~i~~~l~~~~~~~~~~~~~~~~~~~~~~~~ss~~~~ 860 (1299) T 5I08_C 781 FTIAGHEEFIQTSSPKVTIDCSAFVCSNYAACHDLLSEYGTFCDNINSILNEVNDLLDITQLQVANALMQGVTLSSNLNT 860 (1299) T ss_dssp CCCCEEEECCCCCCCEEEECTTTTTCCSCTHHHHHHHHHCTTHHHHHHHHHHHHHHHHHHHHHHHHHHHTTCCCCTTCCC T ss_pred ceeEEEEEEeeccCCCeEEecceeecCCCHHHHHHHHHHHHHHHHHHHHHHHHHHhhcHHHHHHHHHHhccccccccccc Confidence 999999999999999999999999999999999999999999999999999999999999999999999988775 3 Q sp|P0DTC2|SPIK 794 --IKDFGGFNFSQILPDPSK---PSKRSFIEDLLFNKVTLADAGFIKQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDE 868 (1273) Q Consensus 794 --ikdfggfnfsqilpdpsk---pskrsfiedllfnkvtladagfikqygdclgdiaardlicaqkfngltvlpplltde 868 (1273) +..+++|||+.+||.+.. +++||+||||||+||..+|.|+.+.|.+|.+...+|||+|||.|||+.||||++++| T Consensus 861 ~~~~~~~~~N~s~ll~~~~~~~~~~~RS~IEDLLF~KV~t~glG~~~~Y~~Ct~g~~i~DL~CaQ~yNGi~VLP~v~d~~ 940 (1299) T 5I08_C 861 NLHSDVDNIDFKSLLGCLGSQCGSSSRSLLEDLLFNKVKLSDVGFVEAYNNCTGGSEIRDLLCVQSFNGIKVLPPILSET 940 (1299) T ss_dssp ----------------------------CHHHHGGGTSCCCHHHHHHHHHTTSSSCSCCTTHHHHHHSSEEEECCSSCHH T ss_pred CcccCCCCccchhhcccccCCCCCCcccHHHHHhcCceEeCCCChhHHHHHccCCccHHHHhcccccCeEEEeCCCCCHH Confidence 378899999999998763 479999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 869 MIAQYTSALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKL 948 (1273) Q Consensus 869 miaqytsallagtitsgwtfgagaalqipfamqmayrfngigvtqnvlyenqklianqfnsaigkiqdslsstasalgkl 948 (1273) |+|.||++|++|....|||+ |..||||+||.||+||+|+||+||.||||+|||.||.||+.||+.+.++++||.|+ T Consensus 941 ~~amYTasL~g~m~~gg~T~----aaaIPFa~~vq~RlN~v~lt~~VL~~NQk~iA~sFN~A~~~iq~~f~~~~~Al~ki 1016 (1299) T 5I08_C 941 QISGYTTAATVAAMFPPWSA----AAGVPFSLNVQYRINGLGVTMDVLNKNQKLIANAFNKALLSIQNGFTATNSALAKI 1016 (1299) T ss_dssp HHHHHHHHHHHHHHCTTTCS----SSSSCHHHHHHHHHTTSSCSSSHHHHTTTHHHHHHHHHHHHHHGGGGSCCSHHHHH T ss_pred HHHHHHHHHHHHhhccCchh----cccCchHHHHHHHhchhcccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 99999999999999999997 55689999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 949 QDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATK 1028 (1273) Q Consensus 949 qdvvnqnaqalntlvkqlssnfgaissvlndilsrldkveaevqidrlitgrlqslqtyvtqqliraaeirasanlaatk 1028 (1273) |||||++++||++|++||+.|||||||.++||++|||++||++||||||+|||.+|++||+|||+|++|+|||+.||..| T Consensus 1017 Q~VVN~~~~aL~~L~~qL~~nFgAISssI~dIy~RLD~leAdaQVDRLItGRL~aLnafVtQ~L~~~~evr~sr~LA~qK 1096 (1299) T 5I08_C 1017 QSVVNANAQALNSLLQQLFNKFGAISSSLQEILSRLDNLEAQVQIDRLINGRLTALNAYVSQQLSDITLIKAGASRAIEK 1096 (1299) T ss_dssp HHHHHHHHHHHHHHHHGGGCCSSSSSCSTHHHHHHCCSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHHHHHcHHHHHHHHHHHHHHHHHHHHHHHHHHHhHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 1029 MSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDG-KAHFPREGVFVSNGTHWFVTQR 1107 (1273) Q Consensus 1029 msecvlgqskrvdfcgkgyhlmsfpqsaphgvvflhvtyvpaqeknfttapaichdg-kahfpregvfvsngthwfvtqr 1107 (1273) |.|||..||+|.+|||.|.|++|+||.||+|++|+|++|+|.+.++.+++|.+|+++ ++..|++|+|+.+...|++|.| T Consensus 1097 INECVkSQS~R~gFCGnGtHi~Si~q~APnGi~FlH~~y~Pt~~~~V~a~~GlC~~~~~~~~~~~g~f~~~n~~~~~T~r 1176 (1299) T 5I08_C 1097 VNECVKSQSPRINFCGNGNHILSLVQNAPYGLLFIHFSYKPTSFKTVLVSPGLCLSGDRGIAPKQGYFIKQNDSWMFTGS 1176 (1299) T ss_dssp CCCCCTSCCSCSSSSCSSCCSEEEEEEETTEEEEEEEC------------------------------------------ T ss_pred HHHHHhcCCCCccccCCCeEEEeeeeccCCeEEEEEEEecCCeeeEEEEEeeEEecCCeeEEecCcEEEeeCCEEEEecc Confidence 999999999999999999999999999999999999999999999999999999995 7999999999999999999999 Q sp|P0DTC2|SPIK 1108 NFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLN 1187 (1273) Q Consensus 1108 nfyepqiittdntfvsgncdvvigivnntvydplqpeldsfkeeldkyfknhtspdvdlgdisginasvvniqkeidrln 1187 (1273) ++|||..||.+|...-..|||....+|+++..+..|++..|+|||+|+|||+++...|+.++..+|++++|++.||++|+ T Consensus 1177 ~~y~Pr~~t~~d~v~~~sC~v~y~n~~~~~~~~~~p~~~df~~el~~~~~n~~~~~p~~~~~~~~n~t~LNLt~EI~~Lq 1256 (1299) T 5I08_C 1177 SYYYPEPISDKNVVFMNSCSVNFTKAPFIYLNNSIPNLSDFEAELSLWFKNHTSIAPNLTFNSHINATFLDLYYEMNVIQ 1256 (1299) T ss_dssp -------------------------------------------------------------------------------- T ss_pred ccccCCCCCccCeEEeccceeEEEEcChhhCCCCCCCCCChHHHHHHHHhcCCCCCCCCCcccccccceechHHHHHHHH Confidence 99999999999999999999999999999999999999999999999999999977888878899999999999999999 Q sp|P0DTC2|SPIK 1188 EVAKNLNESLIDLQELGKYEQYIKW-PWYIWLGFIAG 1223 (1273) Q Consensus 1188 evaknlneslidlqelgkyeqyikw-pwyiwlgfiag 1223 (1273) |+.|+||+++.+++.+.+.|.|+|| |||+||..+.. T Consensus 1257 evIknLN~S~~ilE~l~~~e~YVkwdpwwVwL~i~l~ 1293 (1299) T 5I08_C 1257 ESIKSLNGSGYIPEAPRDGQAYVRKDGEWVLLSTFLG 1293 (1299) T ss_dssp ------------------------------------- T ss_pred HHHHHHHhcCCCCCCCCCccceecccChhHHHHhhhh Confidence 9999999999999999999999998 99999976543 No 5 >5X5F_B S protein; MERS-CoV, spike glycoprotein, prefusion, single; 4.2A {Middle East respiratory syndrome coronavirus} Probab=100.00 E-value=6.1e-198 Score=1670.09 Aligned_cols=1163 Identities=31% Similarity=0.500 Sum_probs=888.5 Template_Neff=3.800 Q sp|P0DTC2|SPIK 14 QCVNL-TTRTQLPPAYT----NSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNG--T-------KRF 79 (1273) Q Consensus 14 qcvnl-ttrtqlppayt----nsftrgvyypdkvfrssvlhstqdlflpffsnvtwfhaihvsgtng--t-------krf 79 (1273) .|... -...-+.+.++ -+-.+|+||||..++++..+-.|+||.+.-++.+-.- ++|++. + -.+ T Consensus 12 ~C~~~~~~~~~~~~~~~~~idvs~~~G~yYP~~rvysN~TlL~qglfP~~gs~~~~y~---~~~t~~~~~~~~~~~~~~y 88 (1323) T 5X5F_B 12 ACIEVDIQQTFFDKTWPRPIDVSKADGIIYPQGRTYSNITITYQGLFPYQGDHGDMYV---YSAGHATGTTPQKLFVANY 88 (1323) T ss_dssp BCCCEEECGGGTCCCCCCCCCGGGTTTCBCCSSCCBSSCEEEEEEEECCTTCCCEEEC---CEECCBCSSCBCSEEECSG T ss_pred cceecccccccCCCCCCcceecccCceeEeeCCeeeeeeeeeeeceecCCCCcceEEE---EEecCCCCCCCcceeeecc Confidence 36554 23333445555 3446899999999999999999999999988876532 333333 1 356 Q sp|P0DTC2|SPIK 80 DNPVLPFNDGVYFASTEKSNIIR-----------------GWIFGTTLDSKT---Q------SLLIVNNATNVVI----- 128 (1273) Q Consensus 80 dnpvlpfndgvyfasteksniir-----------------gwifgttldskt---q------sllivnnatnvvi----- 128 (1273) +.+..||+||+++...+..|--. .++||+|.+... + +++|+++-.+.++ T Consensus 89 ~~~~~~F~dGifvkv~~~~n~tg~~~~~~~~~~~~~~~ypa~~fGstF~Nts~~~~~~~~~~tlVI~P~~~g~~~~~~~~ 168 (1323) T 5X5F_B 89 SQDVKQFANGFVVRIGAAANSTGTVIISPSTSATIRKIYPAFMLGSSVGNFSDGKMGRFFNHTLVLLPDGCGTLLRAFYC 168 (1323) T ss_dssp GGCCEECTTCEEEEESTTTTSEEECSSSTTCEEEEECCCCCEEEESCEEECTTSCEEEECSEEEEEEEETTTTEEEEEEE T ss_pred CCChhhccCeEEEEEeeeeccCCCeeeCCccccchhhhccceEeeccccCCCCCccccccceEEEEecCCCCchheeeee Confidence 77899999999998877666422 256999998666 5 8889888876543 Q sp|P0DTC2|SPIK 129 --KVCEFQFCNDPFLGVYYHKNN---KSWMES---------EFRVYSSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVF 194 (1273) Q Consensus 129 --kvcefqfcndpflgvyyhknn---kswmes---------efrvyssannctfeyvsqpflmdlegkqgnfknlrefvf 194 (1273) ...+..-|..|..-+++.-+. .+|..+ +++.|....+|+|.|. +.|-+|... ..|- |.| T Consensus 169 ~~~prtit~C~~p~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~nfT~d~~~--~wf~----~~F 241 (1323) T 5X5F_B 169 ILEPRSGNHCPAGNSYTSFATYHTPATDCSDGNYNRNASLNSFKEYFNLRNCTFMYT-YNITEDEIL--EWFG----ITQ 241 (1323) T ss_dssp EEEECCSBTSTTSTTCCCCCEEECHHHHSCTTCCCTTHHHHHHHHHEEEEEEEEEEE-EECCCCCCC--EEEE----EEE T ss_pred cccccccCcCCCCCeEeeeeecCCCCccCCCCcccccccccchhHhcccCCceEEEe-eecCcchhh--heee----EEe Confidence 322333455555555432221 345333 6778889999999875 344333211 1111 899 Q sp|P0DTC2|SPIK 195 KNID-GYFKIYSKHTPINL---VRDLPQGFSALEPLVDLPIGINITRFQTLLALHRSYLTPGDSSSGWTAGAAAYYVGYL 270 (1273) Q Consensus 195 knid-gyfkiyskhtpinl---vrdlpqgfsaleplvdlpiginitrfqtllalhrsyltpgdsssgwtagaaayyvgyl 270 (1273) +..| |.|-+|.-++..+. ..-+| |+..+.+.. .+-|+..++ .+.+. ..++|||++| T Consensus 242 ~~~~~G~f~~Y~~d~~~~~~f~f~~~~-~~~~~~yy~---------------v~p~~~~~~---~~~~~-~~~~~~v~~L 301 (1323) T 5X5F_B 242 TAQGVHLFSSRYVDLYGGNMFQFATLP-VYDTIKYYS---------------IIPHSIRSI---QSDRK-AWAAFYVYKL 301 (1323) T ss_dssp ETTEEEEEESTTTCTTTCCBEEEEEEC-CCSCCCEEE---------------ECCEEECCC---GGGCC-EECCEEEEEC T ss_pred eecCceeEEEEEEeccCCcceeccccc-ceeccceee---------------eeeeeecCC---ccccc-eeEEEEEEEc Confidence 9999 99999876654332 12222 444444443 233444444 45566 7889999999 Q sp|P0DTC2|SPIK 271 QPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASV 350 (1273) Q Consensus 271 qprtfllkynengtitdavdcaldplsetkctlksftvekgiyqtsnfrvqptesivrfpnitnlcpfgevfnatrfasv 350 (1273) .+|+|||+|++||.|++||||+-|+++|-||..+||.+++|+|++|+||+||....+|.++. ..|+|.++++ .++.++ T Consensus 302 ~~~~yLl~fd~nG~I~~avDC~~~~~seL~C~~~sf~~~tGVY~~S~y~aqp~~~v~~~~~~-~~C~~~~~~~-~~~P~p 379 (1323) T 5X5F_B 302 QPLTFLLDFSVDGYIRRAIDCGFNDLSQLHCSYESFDVESGVYSVSSFEAKPSGSVVEQAEG-VECDFSPLLS-GTPPQV 379 (1323) T ss_dssp EEEEEEEEECTTSCEEEEEETTSCHHHHHHHTTTCSCCCSSEECCCCCBBCCCSCEECC----CCCCCHHHHS-BCCCBG T ss_pred cceeEEEeecCCCeEEEEEecCCCccchheeEeceecCCCCeeecCCEEEEeeeEEEEecCC-CCCCchHHhc-CCCCCc Confidence 99999999999999999999999999999999999999999999999999999999999999 9999999999 889999 Q sp|P0DTC2|SPIK 351 YAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFT 430 (1273) Q Consensus 351 yawnrkrisncvadysvlynsasfstfkcygvsptklndlcftnvyadsfvirgdevrqiapgqtgkiadynyklpddft 430 (1273) |.|.|+.++||..|+|+|++...+++|+||||+|.||.++||..|++|.|.|..+..++++||++|-|++||||+|+||+ T Consensus 380 ~~w~R~~f~nCnfN~s~Lls~~~~~sf~C~gIspskLa~mCfsSvtiD~Faip~s~~~~Lq~G~~G~i~~yNYKld~~~~ 459 (1323) T 5X5F_B 380 YNFKRLVFTNCNYNLTKLLSLFSVNDFTCSQISPAAIASNCYSSLILDYFSYPLSMKSDLSVSSAGPISQFNYKQSFSNP 459 (1323) T ss_dssp GGCEEEEECSEEECHHHHHHHSEEEEEEEESSCHHHHHHSCCSCEEEEEEECCGGGGGGSCTTCCSHCCCCCCCCCSSSC T ss_pred ceeEEeEEecCCCcHHHHHhhceeeeeeecCCCHHHHcccccceeeEEEEecCccccceecCCCCChhhhccccCCCCCC Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 431 GCVIAWNSNNLDSKV--GGNYNYLYRLFRKSNLKPFERDISTEI---YQAGSTPCNGV-EGFNCYFPLQSY--------- 495 (1273) Q Consensus 431 gcviawnsnnldskv--ggnynylyrlfrksnlkpferdistei---yqagstpcngv-egfncyfplqsy--------- 495 (1273) ||+++|+-...+..+ -.+|+|+.|-+++.. ++. ++. ..+ .+-|+-. ...+|+.|...+ T Consensus 460 sC~l~y~~pa~~vn~t~p~~y~yi~~~~~~~~-----~~~-~~~~~~~~~-~~~cpc~~~~~~~~~~~~~~~~~~~~~~~ 532 (1323) T 5X5F_B 460 TCLILATVPHNLTTITKPLKYSYINKCSRLLS-----DDR-TEVPQLVNA-NQYSPCVSIVPSTVWEDGDYYRKQLSPLE 532 (1323) T ss_dssp EEEEEEECCSSCCSBCCCSEEEEEEEEEEECT-----TSS-CEEECCCCT-TSCCTTTTTSCSSCSSTTCEEEEECCTTT T ss_pred ccEEEEEcCccccccCCCccceeeeeeeccCC-----CCC-Ccchhhccc-cccCCCCccCCccccCCCCcccccccccc Confidence 999999955533322 445666555555433 222 222 111 1111100 012344443222 Q sp|P0DTC2|SPIK 496 --GFQP----TNGVGYQPYRVVVLSFELLHAPATVCGP-----KKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQ 564 (1273) Q Consensus 496 --gfqp----tngvgyqpyrvvvlsfellhapatvcgp-----kkstnlvknkcvnfnfngltgtgvltesnkkflpfqq 564 (1273) |..+ ..++++|++.++|++++..+.++|||++ |.+|.++.++||++|+.|+||+||++|++..+..+|. T Consensus 533 ~~~~~~~~~~~~~~~~~~~g~~Vis~k~~~~s~tVCp~~~d~~~~~T~~~l~vCV~YnlYGiTGtGVf~~sn~~~~~~Q~ 612 (1323) T 5X5F_B 533 GGGWLVASGSTVAMTEQLQMGFGITVQYGTDTNSVCPKLEFANDTKIASQLGNCVEYSLYGVSGRGVFQNCTAVGVRQQR 612 (1323) T ss_dssp TSSEEEEEEEEEECCSSCEEEEEEECCCCSSCCCEEECC------CCSSSCCCSSCEECSSCCCCCCCEECCCCSCSSSC T ss_pred CCchhcccccccccccceeEEEEEEeEcCCCccccCCCcccCCcCCcchhcCceeeEEecceeeeEEEEecCccccccee Confidence 2233 4589999999999999999999999988 5668999999999999999999999999999999999 Q sp|P0DTC2|SPIK 565 FGRDIADTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRV--YSTGSNV 642 (1273) Q Consensus 565 fgrdiadttdavrdpqtleilditpcsfggvsvitpgtntsnqvavlyqdvnctevpvaihadqltptwrv--ystgsnv 642 (1273) |..|-.+-..+.|| +++++.+|+||..|+|||+++++ ++..|+||++++|.+|...+|..+.+|.|+. ++...+. T Consensus 613 f~yds~Gnl~gfk~-~tg~vY~I~PC~s~~VSViy~~~--s~e~AlLf~~v~C~~v~t~~~~~~~~~~~~~~~~~~~~~~ 689 (1323) T 5X5F_B 613 FVYDAYQNLVGYYS-DDGNYYCLRACVSVPVSVIYDKE--TKTHATLFGSVACEHISSTMSQYSRSTRSMLKRRDSTYGP 689 (1323) T ss_dssp CCBCSSSCBCCCCC-SSSCCEECCCCCBCCCBEECCTT--TTCCCCBCSSCCTTTCCTTCTTBSCSSSSCCC-------- T ss_pred EEEcCCCCEEEEEe-CCCCEEEEeeceeeceeEEEeCC--CCceEEEeCCccccceecceeeecCCCchhcccccCCCCC Confidence 99999999999999 99999999999999999999998 7799999999999999999999999999998 7778889 Q sp|P0DTC2|SPIK 643 FQTRAGCLIGAEHVNN-SYECDIPIGAGICASYQTQTNS-PRRARSVAS-QSII--AYTMSLGAENSVAYSNNSIAIPTN 717 (1273) Q Consensus 643 fqtragcligaehvnn-syecdipigagicasyqtqtns-prrarsvas-qsii--aytmslgaensvaysnnsiaiptn 717 (1273) |||-+||++||++.+. .+|||+|+|+|+|+.|.+...+ +|+.|++.. ..+. +|+|.+-. .++.+++..|.||+| T Consensus 690 fdT~~GCVvnA~n~t~~V~~C~lplG~glC~~y~~~s~~~~r~~~~~~~~~~l~~~~y~~p~~~-~~~~~~~~~i~IP~n 768 (1323) T 5X5F_B 690 LQTPVGCVLGLVNSSLFVEDCKLPLGQSLCALPDTPSTLTPRSVSSVPGEMRLASIAFNHPIQV-DQLNSSYFKLSIPTN 768 (1323) T ss_dssp ---CBCCSSSCBSSCCCCCCCCCCCTTCCSSSCCCCCC------------CCCCCCCCCCCCCC-CCCCSSCCEEEECCC T ss_pred CCCccceeeecccCCCceeeCCCCCCcceecCCCCcCcCccccccCCCCceEEEEEeecCCeee-cccCCCCeeEEcccc Confidence 9999999999999988 8999999999999999988755 344444443 3344 67777765 778889999999999 Q sp|P0DTC2|SPIK 718 FTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDF 797 (1273) Q Consensus 718 ftisvtteilpvsmtktsvdctmyicgdstecsnlllqygsfctqlnraltgiaveqdkntqevfaqvkqiyktppikdf 797 (1273) |||+|++|-+.++|.|.+|||.+|+||++.+|.+||.|||+||..+|+||.|.+.++|.+..+++..+++-++.+-+..| T Consensus 769 Ft~~v~~EyiQ~~~~kv~iDC~~YVC~~~~~C~~lL~qYgs~C~~I~~aL~~~~~~~d~~~~~~~~~~~~~~~~~~~~~f 848 (1323) T 5X5F_B 769 FSFGVTQEYIQTTIQKVTVDCKQYVCNGFQKCEQLLREYGQFCSKINQALHGANLRQDDSVRNLFASVKSSQSSPIIPGF 848 (1323) T ss_dssp CCCCCCCCBCCCCCCCCEECTTSSSSSSCHHHHHHHHTSHHHHHHHHHHHHHHHHHHHHHHHHHHHTTCSSCCCCCCSCC T ss_pred eEEEEEEEEEeecCCceEEechhhccCCCHHHHHHHHHHHHHHHHHHHHHHHHhhhccHHHHHHHHhccccccCCCcCCC Confidence 99999999999999999999999999999999999999999999999999999999999999999999999998888887 Q sp|P0DTC2|SPIK 798 -GGFNFSQILPDPS---KPSKRSFIEDLLFNKVTLADAGFIKQYGDCLGDI--AARDLICAQKFNGLTVLPPLLTDEMIA 871 (1273) Q Consensus 798 -ggfnfsqilpdps---kpskrsfiedllfnkvtladagfikqygdclgdi--aardlicaqkfngltvlpplltdemia 871 (1273) |+|||+.+||.+. ++++||+||||||+||.+.|.||.+.|+.|.... ..|||+|||.+||+.||||..++||.+ T Consensus 849 ~~~~N~s~ll~~~~~~~~~~~RS~iEDLLF~KV~t~g~G~~~~Y~~C~~g~~~~i~DL~CAQ~yNGi~VLP~v~~~~le~ 928 (1323) T 5X5F_B 849 GGDFNLTLLEPVSISTGSRSARSAIEDLLFDKVTIADPGYMQGYDDCMQQGPASARDLICAQYVAGYKVLPPLMDVNMEA 928 (1323) T ss_dssp BTTBCCTTSCCC--------CCCHHHHHHHHSSCCCCCCSSSHHHHHHTC--------CCTTTSCSEECCCCSSCHHHHH T ss_pred CCCcccceeccCCCCCCCccceeHHHHHhcceeeeCCCCcccChhhhcccCCccHHHHhheeEeCCEeecCCcCCHhHHH Confidence 5799999999876 3468999999999999999999999999999554 899999999999999999999999999 Q sp|P0DTC2|SPIK 872 QYTSALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDV 951 (1273) Q Consensus 872 qytsallagtitsgwtfgagaalqipfamqmayrfngigvtqnvlyenqklianqfnsaigkiqdslsstasalgklqdv 951 (1273) +|+.+++.+....||++|..++..|||++++.+|+|++++++++|.+|||.|||.||.|||.||+.+.++++||.|+|++ T Consensus 929 ~yt~SdvG~l~~~r~e~G~tsaaaIpfs~~Vy~RLN~l~~~~~vL~~nq~~Ia~sFN~aIg~iq~gf~t~~~Al~kIq~v 1008 (1323) T 5X5F_B 929 AYTSSLLGSIAGVGWTAGLSSFAAIPFAQSIFYRLNGVGITQQVLSENQKLIANKFNQALGAMQTGFTTTNEAFQKVQDA 1008 (1323) T ss_dssp HHHHHHHHHHHHHTTCSCCC-CCCCCHHHHHHHHHHHSSCCCHHHHHTTCCSHHHHHHHHHHHHHCCTTTCTTHHHHHHH T ss_pred HHHHHHHHhhhcccccccCCccccCCchHHHHHHHHhhhchHHHHHHHHHHHHHHHHHHHHHHhhccccHHHHHHHHHHH Confidence 99999999888889999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 952 VNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSE 1031 (1273) Q Consensus 952 vnqnaqalntlvkqlssnfgaissvlndilsrldkveaevqidrlitgrlqslqtyvtqqliraaeirasanlaatkmse 1031 (1273) ||+++++|++|..||+.|||||||.+++|+.|||++||++|+||||+|||.+|.+||+|||+|++|+|+|+.||..|+.| T Consensus 1009 VN~~~~als~L~~qLn~~FgAISssi~gI~~RLd~lEa~iqvdrlInGRL~aLn~~Vtq~l~~~~~v~~sr~LA~qKiNE 1088 (1323) T 5X5F_B 1009 VNNNAQALSKLASELSNTFGAISASIGDIIQRLDVLEQDAQIDRLINGRLTTLNAFVAQQLVRSESAALSAQLAKDKVNE 1088 (1323) T ss_dssp HHHHHCCCCCHHHHHSSSCSSSCSSSTTTTTSSCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC T ss_pred HHHHHHHHHHHHHHHhhhcccchhcHhHHHHHHHHHHHHhCCChhhhcHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 1032 CVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHD---GKAHFPREGVFVSNG-----THWF 1103 (1273) Q Consensus 1032 cvlgqskrvdfcgkgyhlmsfpqsaphgvvflhvtyvpaqeknfttapaichd---gkahfpregvfvsng-----thwf 1103 (1273) ||..||+|.+|||.|.|++|+||.||+|++|+|.+|+|.+.++.+++|.+|++ +++..|+.|.|+.+. .+|+ T Consensus 1089 CVKSQS~R~gFCGnG~Hi~S~~q~AP~Gi~F~H~~~~Pt~~~~v~a~~GlC~~~~~~~~~~~~~g~~~~~~~~~~~~~~~ 1168 (1323) T 5X5F_B 1089 CVKAQSKRSGFCGQGTHIVSFVVNAPNGLYFMHVGYYPSNHIEVVSAYGLCDAANPTNCIAPVNGYFIKTNNTRIVDEWS 1168 (1323) T ss_dssp CCCSCCSSSTTSCSSSEEECCBCCCSSSCBBCCEECCCCCCEEEECCSCCCCSSCCCCCCSSSCCCCSSSSCCCCSSSCC T ss_pred HHHhcccccCCCCCCeeeEEeeeccCCeEEEEEEEecccceeEEEEEEEEeecCCCCceeeccCeEEEEeCCceeeceEE Confidence 99999999999999999999999999999999999999999999999999996 688999999999876 5699 Q sp|P0DTC2|SPIK 1104 VTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPL--QPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQK 1181 (1273) Q Consensus 1104 vtqrnfyepqiittdntfvsgncdvvigivnntvydpl--qpeldsfkeeldkyfknhtspdvdlgdisginasvvniqk 1181 (1273) +|.|++|+|..||.+|+. --.|+|...-+|+++..|+ +|+...|+|||+|+|||+++...|+.++..+|+++.|++. T Consensus 1169 ~T~r~~y~P~~~t~~~v~-i~sc~V~y~n~~~~~l~~~v~~p~yiDfn~el~~~~~n~~~~~p~l~~l~~fN~T~LNLt~ 1247 (1323) T 5X5F_B 1169 YTGSSFYAPEPITSLNTK-YVAPQVTYQNISTNLPPPLLGNSTGIDFQDELDEFFKNVSTSIPNFGSLTQINTTLLDLTY 1247 (1323) T ss_dssp CCCCSSSCCCCCCCSSTT-SCC---------------------------------------------------------- T ss_pred EeCCccccCccCCCCCEE-EECCcceEEecCCCCCCCccCCCCCCChHHHHHHHHhcCCCCCCCCCchhcceecccchHH Confidence 999999999999999955 5778999999999999984 6899999999999999999988888889999999999999 Q sp|P0DTC2|SPIK 1182 EIDRLNEVAKNLNESLIDLQELGKYEQYIKWPWYIWLGF 1220 (1273) Q Consensus 1182 eidrlnevaknlneslidlqelgkyeqyikwpwyiwlgf 1220 (1273) ||++|+|+.|+||+++|||++|++||+|||||||+--|- T Consensus 1248 EI~~Lq~~i~~LN~s~idLe~Ln~~e~YiKW~~~~~~~~ 1286 (1323) T 5X5F_B 1248 EMLSLQQVVKALNESYIDLKELGNYTYYNKEFRLVPRGS 1286 (1323) T ss_dssp --------------------------------------- T ss_pred HHHHHHHHHHHHHhccCCHHHhCceeeeEeeeeecCCCC Confidence 999999999999999999999999999999999987653 No 6 >6VSJ_A Spike glycoprotein, Carcinoembryonic antigen-related cell; MHV spike, CEACAM1a, Complex, Glycoprotein; HET: NAG; 3.94A {Murine coronavirus (strain A59)} Probab=100.00 E-value=2.1e-195 Score=1649.54 Aligned_cols=1145 Identities=30% Similarity=0.512 Sum_probs=889.4 Template_Neff=4.000 Q sp|P0DTC2|SPIK 9 PLVSSQCVNLTTRTQLP---PAYT-----NSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAI--HVSGTNGTKR 78 (1273) Q Consensus 9 plvssqcvnlttrtqlp---payt-----nsftrgvyypdkvfrssvlhstqdlflpffsnvtwfhai--hvsgtngtkr 78 (1273) ++....|...-...-++ |.++ -+-.+|+||||..++|+..+-.|+||.+.-++.+-+-.- |... .--. T Consensus 22 ~i~~~~C~~~~~~~~~~~~~~~~s~~~idvs~~~G~yYPd~rvysN~TlL~qGLFP~~gs~~~~Y~~sgt~~~s--~~~~ 99 (1275) T 6VSJ_A 22 YIGDFRCIQLVNSNGANVSAPSISTETVEVSQGLGTYYVLDRVYLNATLLLTGYYPVDGSKFRNLALRGTNSVS--LSWF 99 (1275) T ss_dssp CCSSBCCCCCSEECCCCCCCCCCCSCBCCCTTSTTCBCCTTCBCCSCCCEEEEEEECTTCBCCBCCCEESSEEC--GGGS T ss_pred cccCcceeEeecCCCCCCCCCCCcceeeeeecceeEEEeCCeEEeceeeeeccccCCCCCceeeEEeeccCCCC--cccc Confidence 34555677653333333 3444 345689999999999999999999999998887654222 2222 1346 Q sp|P0DTC2|SPIK 79 FDNPVLPFNDGVYFASTEKSNI--------IRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVYYHKNNK 150 (1273) Q Consensus 79 fdnpvlpfndgvyfasteksni--------irgwifgttldsktqsllivnnatnvvikvcefqfcndpflgvyyhknnk 150 (1273) +++++.||+||+++...+.+|- -..++||+|.+..+++++|+++-+...|.+|.|..|..|...+++.-+|. T Consensus 100 y~~~~~~F~dGIfVkV~~~kn~t~~~~~~~ypa~~fGSTF~Nts~tvVI~P~~~~r~itvCq~~vC~~p~~~~~p~~g~~ 179 (1275) T 6VSJ_A 100 QPPYLNQFNDGIFAKVQNLKTSTPSGATAYFPTIVIGSLFGYTSYTVVIEPYNGVIMASVCQYTICQLPYTDCKPNTNGN 179 (1275) T ss_dssp STTTSCCCSSCEEEEEECCGGGSCTTCCCSSCCEEEESSCSTTSCEEEECEETTEECCEEECCCBBSSCCEESSCCCSSC T ss_pred cCCcccccCCcEEEEeeeeccCCCCcchhccceeEEecccCCCceEEEEeCCCceeEeEEEEEEEcCCCeeEEccCCCCC Confidence 7788999999999998887765 35678999999999999999999999999999999999999888744332 Q sp|P0DTC2|SPIK 151 SWMESEFRVYSSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVFKNIDGYFKIYSKHTPINL---VRDLPQGFSALEPLV 227 (1273) Q Consensus 151 swmesefrvyssannctfeyvsqpflmdlegkqgnfknlrefvfknidgyfkiyskhtpinl---vrdlpqgfsaleplv 227 (1273) +..+ ++. ....+|+|.|. +.|-+|... ..|- |.|+..||.|-+|..+...+. ..-+| |...+.+. T Consensus 180 ~~~~--~~~-~d~~nc~f~~~-~nfT~d~~~--~~~~----~~F~~~dG~fy~Yyad~~~~~~f~f~~~~-~~~~~~yy- 247 (1275) T 6VSJ_A 180 KLIG--FWH-TDVKPPICVLK-RNFTLNVNA--DAFY----FHFYQHGGTFYAYYADKPSATTFLFSVYI-GDILTQYY- 247 (1275) T ss_dssp TTCC--SSB-CCCSCCCEEEE-CCEECCTTC--SEEE----EEBCEETTEECCEECSSSSCBEECCCCCC-SSCCCEEE- T ss_pred ceee--ece-ecCCCCEEEEe-eeeccCccc--ceee----EEEEEcCCeEEEEEECCCcCcceeecccc-cceeceeE- Confidence 3322 233 67889999764 455444322 1221 999999999988876644332 11222 33333333 Q sp|P0DTC2|SPIK 228 DLPIGINITRFQTLLALHRSYLTPGDSSSGWTAGAAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFT 307 (1273) Q Consensus 228 dlpiginitrfqtllalhrsyltpgdsssgwtagaaayyvgylqprtfllkynengtitdavdcaldplsetkctlksft 307 (1273) .+-|+..++ .+.+ ..++|||++|.+|+|||+|++||.||+||||+-|+++|-||..+||. T Consensus 248 ---------------v~~~~~~~~---~~~~--~~~~~~v~~L~~~~~ll~fd~~G~i~~avDC~~~~~~el~C~~~sf~ 307 (1275) T 6VSJ_A 248 ---------------VLPFICNPT---AGST--FAPRYWVTPLVKRQYLFNFNQKGVITSAVDCASSYTSEIKCKTQSML 307 (1275) T ss_dssp ---------------ECCEECCCS---SCSC--CCCEEEEEEEEEEEEECCBCSSSCBCCCBCTTSCHHHHHHHHHTSSS T ss_pred ---------------EeeeeecCC---CCCC--cccEEEEEeccceeEEEEecCCCeEeEEEecccCccceeeeEecccc Confidence 233444333 2223 67899999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 308 VEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKL 387 (1273) Q Consensus 308 vekgiyqtsnfrvqptesivrfpnitnlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptkl 387 (1273) +++|+|++|+||+||....+|.++.+..|+|.++++|.++.++|.|.|+.++||..|+++|++..++++|+||||+|.|| T Consensus 308 ~~~GVY~~s~y~a~p~~~v~~~~~~~~~C~~~~~~~~~~~P~p~~w~R~~~~nCnfn~s~Ll~~~~~~~f~C~~ispskl 387 (1275) T 6VSJ_A 308 PSTGVYELSGYTVQPVGVVYRRVANLPACNIEEWLTARSVPSPLNWERKTFQNCNFNLSSLLRYVQAESLFCNNIDASKV 387 (1275) T ss_dssp CCSSCEECCCCCCCCCCCCCCCCCCCCBCCTHHHHTCSEEECTTSCEEEEECSCBCCHHHHHHHSEEEECCBSSCCTTTS T ss_pred CCCceeecCCeEEEeeeEEEEecCCCCCCCHHHHHhcCCCCCchhcEEeEEecCCCCHHHHHhheeeccceecCCCHHHH Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 388 NDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSK----VGGNYNYLYRLFRKSNLKP 463 (1273) Q Consensus 388 ndlcftnvyadsfvirgdevrqiapgqtgkiadynyklpddftgcviawnsnnldsk----vggnynylyrlfrksnlkp 463 (1273) .++||..|++|.|.|..+..++++||++|-|++||||+|+||+||+++|+-...+.. --++||+-|+.-++..++| T Consensus 388 ~~~CfssvtiD~F~ip~~~~~~l~~g~~g~i~~yNYkl~~~~~~C~l~~~~~~~~~~~t~~np~~~~~~~~~~~~~~f~~ 467 (1275) T 6VSJ_A 388 YGRCFGSISVDKFAVPRSRQVDLQLGNSGFLQTANYKIDTAATSCQLHYTLPKNNVTINNHNPSSWNRRYGFNDAGVFGK 467 (1275) T ss_dssp TTCCBSEEEEEEECCCSTTGGGGSTTCCSSHHHHTCCCCSSSCEEECEEEECTTTCEEECCCCCHHHHHHSCCTTTTTTT T ss_pred cccccCeeEEEEEeccchhceeecCCCCcHhHhccccCCCCCCceEEEEEcCcccccccCCCCccchhcccccccccccC Confidence 999999999999999999999999999999999999999999999999996543322 2357888888888899999 Q sp|P0DTC2|SPIK 464 FERDISTEIY--QAGSTPCNG--V------------------EGFNCYF------------PLQSYGFQPTNGVGYQPY- 508 (1273) Q Consensus 464 ferdisteiy--qagstpcng--v------------------egfncyf------------plqsygfqptngvgyqpy- 508 (1273) +++|..-..+ ..+.+-|+. . .|..|+- |..+---+|+..+||+++ T Consensus 468 ~~~dvvy~~~~~~~~~~~cpC~~~~~~~~ct~~~~~~~~~~~~~~~c~g~~vi~~~~g~~~~~~~c~c~~~af~gws~d~ 547 (1275) T 6VSJ_A 468 NQHDVVYAQQCFTVRSSFCPCAQPDIVSPCTTQTKPKSAFVNVGDHCEGLGVLEDNCGNADPHKGCICANNSFIGWSHDT 547 (1275) T ss_dssp CSSEEEEESCBBCCCSCCCSCC-----------CCCCBCCCCTTCCCCCBEECTTSEECCCSSSSCEECTTCEESEEEEE T ss_pred cccceeeccccccCCCCCCCCCCCCcCCCCCCCCCCccceeccccccceeEEeeccCCCCCCCCCccccCCcccccCccc Confidence 9999876533 233333330 0 1112211 001111256777888888 Q sp|P0DTC2|SPIK 509 -----RVVVLSFELLHA--PATVCGP---KKSTNLVKNKCVNFNFNGLTGTGVLTESN-KKFLPFQQFGRDIADTTDAVR 577 (1273) Q Consensus 509 -----rvvvlsfellha--patvcgp---kkstnlvknkcvnfnfngltgtgvltesn-kkflpfqqfgrdiadttdavr 577 (1273) |++|+|++||++ ++|||+. +..++++.++||++|..|.||+||+++.+ ..+-.+|.+..+.+.-..++| T Consensus 548 c~~~~r~~i~~~~~ln~~~s~tvCp~~~~~~~t~I~ln~CVdYNIYGitGtGVItnvt~~~~~~~qgL~yS~sG~L~~FK 627 (1275) T 6VSJ_A 548 CLVNDRCQIFANILLNGINSGTTCSTDLQLPNTEVVTGICVKYDLYGITGQGVFKEVKADYYNSWQTLLYDVNGNLNGFR 627 (1275) T ss_dssp CEETTEEEEEEEEEEESTTCCSBBCSSSCCCCCCCCCSSCEEEEETTEEEEEEEECCCCCCCCSSCCCEECTTSCEEEEE T ss_pred cccCCceeeeeeeeccCCCCCCCCCCcCCCCCceEEeCeEEEEEeCCCeeEEEEEecCCcccccCccEEEeCCCCEEEEE Confidence 999999999998 8999998 34689999999999999999999999944 444466778888889999999 Q sp|P0DTC2|SPIK 578 DPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEHVN 657 (1273) Q Consensus 578 dpqtleilditpcsfggvsvitpgtntsnqvavlyqdvnctevpvaihadqltptwrvystgsnvfqtragcligaehvn 657 (1273) ++.++++..|+||..+.++++..|. +...|+++..++|+++....+....+| .+.|+|-.||+++++|.+ T Consensus 628 n~ttg~~YsV~PC~~v~qQvVV~~~--sivgalls~n~~cs~~~~n~~~~~~~~--------~~~~~t~~gCv~~a~~~t 697 (1275) T 6VSJ_A 628 DLTTNKTYTIRSCYSGRVSAAFHKD--APEPALLYRNINCSYVFSNNISREENP--------LNYFDSYLGCVVNADNRT 697 (1275) T ss_dssp CTTTCCEEEEECCCCCEEECCCCTT--CSSCCEEETTCCHHHHHHTTCCSSCCC--------SCCEECSSSEECSCSEEE T ss_pred cCCCCCEEEEEeCceeceeEEEeCC--CceeEEEEeccceeceeeccceeeeCC--------CcceeccccceeccccCC Confidence 9999999999999999999999876 567789999999999886444333333 344999999999999887 Q sp|P0DTC2|SPIK 658 N--SYECDIPIGAGICASYQTQTNSPRRARSVASQ-SIIA---YT-MSLGAENSVAYSNNSIAIPTNFTISVTTEILPVS 730 (1273) Q Consensus 658 n--syecdipigagicasyqtqtnsprrarsvasq-siia---yt-mslgaensvaysnnsiaiptnftisvtteilpvs 730 (1273) + ..+|++|.|.|||+.+..-.-.+ |++..+ .+.. +. +..........+...|.||+||||+|++|-++++ T Consensus 698 ~~~~~~c~~~~g~giC~dg~~~~~~~---~~~~~~~~~~~~~~~~~~~~~~s~~~~~~~~~i~IP~nFtlsv~~EyiQt~ 774 (1275) T 6VSJ_A 698 DEALPNCDLRMGAGLCVDYSKSRRAH---RSVSTGYRLTTFEPYTPMLVNDSVQSVDGLYEMQIPTNFTIGHHEEFIQTR 774 (1275) T ss_dssp EEEESSCSEEETTTEEEEECTTTCSS---SSSTTSEEEEEECSCCCCBCCCSCSSSCCBCSCCBCCCCEEECCEEECCCC T ss_pred CCcCCCCCCccceEEccCcccceecc---cccCCCceeecccCCcccccCCCCCccCcceEEEccCceEEEEEEEEeecC Confidence 5 68999999999999998833222 221111 1111 11 1111125566777899999999999999999999 Q sp|P0DTC2|SPIK 731 MTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTP-P----I-KDFGGFNFSQ 804 (1273) Q Consensus 731 mtktsvdctmyicgdstecsnlllqygsfctqlnraltgiaveqdkntqevfaqvkqiyktp-p----i-kdfggfnfsq 804 (1273) |.|.+|||.+|+||++.+|.+||.|||+||..+|+||.|.+..+|....++++.+++.++.+ + | ...|+|||+. T Consensus 775 ~~kVsIDCa~YVC~g~~rC~~LL~QYgsfC~~I~~aL~~~~~~~d~~~~~~~~~~~~~~~~s~~~~~~~~~~~~~fN~s~ 854 (1275) T 6VSJ_A 775 SPKVTIDCAAFVCGDNTACRQQLVEYGSFCVNVNAILNEVNNLLDNMQLQVASALMQGVTISSRLPDGISGPIDDINFSP 854 (1275) T ss_dssp CCEEECCHHHHHSCSSHHHHHHHGGGHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTCCCCBCC---------------- T ss_pred CCCeEEEhhheecCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhccccccccCCCCCCCCCCCccchh Confidence 99999999999999999999999999999999999999999999999999999999998875 2 2 4456799999 Q sp|P0DTC2|SPIK 805 ILPD-----------PSKPSKRSFIEDLLFNKVTLADAGFIKQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQY 873 (1273) Q Consensus 805 ilpd-----------pskpskrsfiedllfnkvtladagfikqygdclgdiaardlicaqkfngltvlpplltdemiaqy 873 (1273) +||. |+++++||+|||||||||+.+|.|+.+.|.+|.+...+|||+|||.|||+.||||++++||+|.| T Consensus 855 ll~~~~~~~~~~~~~~~~~~~RSaIEDLLF~KV~t~glG~~~~Yk~Ct~g~~i~DL~CAQyyNGImVLPpvvd~~~~amY 934 (1275) T 6VSJ_A 855 LLGCIGSTCAEDGNGPSAIRGRSAIEDLLFDKVKLSDVGFVEAYNNCTGGQEVRDLLCVQSFNGIKVLPPVLSESQISGY 934 (1275) T ss_dssp ------CCSSCCSSSTTTTTTTTHHHHHHHHHCSSCTTHHHHHHHHHHTTSSTTSSHHHHHHTTCEEECCSSCHHHHHHH T ss_pred hcccccCCcccCCCCCCccCcccHHHHHHcceeeecCCchHHHHHhccCCcchHHhhcccccCcEEEeCCCCCHHHHHHH Confidence 9986 56668999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 874 TSALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVN 953 (1273) Q Consensus 874 tsallagtitsgwtfgagaalqipfamqmayrfngigvtqnvlyenqklianqfnsaigkiqdslsstasalgklqdvvn 953 (1273) |++|++|....|||+ |..||||+||.||+||+|+||+||.||||+|||.||.||+.||+.++++++||.|+||||| T Consensus 935 TasL~g~m~~gg~Ta----aaaIPFa~~vq~RlN~v~lt~~VL~~NQk~iA~sFN~A~~~iq~~f~~~~~Al~kiQ~VVN 1010 (1275) T 6VSJ_A 935 TTGATAAAMFPPWSA----AAGVPFSLSVQYRINGLGVTMNVLSENQKMIASAFNNALGAIQDGFDATNSALGKIQSVVN 1010 (1275) T ss_dssp HHHHHHTTSCSSSCS----STTCCHHHHHHHHGGGTSCHHHHTTHHHHHHHHHHHHHHHHHHHHHSSCCHHHHHHHHHHH T ss_pred HHHHHHHhhcccchh----cccCchHHHHHHHhcccccchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 999999999999997 5568999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 954 QNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECV 1033 (1273) Q Consensus 954 qnaqalntlvkqlssnfgaissvlndilsrldkveaevqidrlitgrlqslqtyvtqqliraaeirasanlaatkmsecv 1033 (1273) ++++||++|++||+.|||||||.++||++|||++||++||||||+|||.+|++||+|||+|++|+|||+.||..||.||| T Consensus 1011 ~q~~aL~~L~~qL~~nFgAISssI~dIy~RLD~leAdaQVDRLItGRL~aLnafVtQ~L~~~~evr~sr~LA~qKINECV 1090 (1275) T 6VSJ_A 1011 ANAEALNNLLNQLSNRFGAISASLQEILTRLEAVEAKAQIDRLINGRLTALNAYISKQLSDSTLIKVSAAQAIEKVNECV 1090 (1275) T ss_dssp HHHHHHHHHHHGGGSCCSSSCSCHHHHHHHSCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC T ss_pred HHHHHHHHHHHHHHHHHhHHHHHHHHHHHHHHHHHHHHHHHHHHHhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 1034 LGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDG-KAHFPREGVFVSNGTHWFVTQRNFYEP 1112 (1273) Q Consensus 1034 lgqskrvdfcgkgyhlmsfpqsaphgvvflhvtyvpaqeknfttapaichdg-kahfpregvfvsngthwfvtqrnfyep 1112 (1273) ..||+|.+|||.|.|++|+||.||+|++|+|++|+|.+.++.+++|.+|+++ ++..|+.|+|+.+...|++|.|++||| T Consensus 1091 KSQS~R~gFCGnGtHi~Si~q~APnGi~FlH~~y~Pt~~~~V~a~~GlC~~~~~~~~p~~g~fv~~n~~~~iT~r~~Y~P 1170 (1275) T 6VSJ_A 1091 KSQTTRINFCGNGNHILSLVQNAPYGLYFIHFSYVPISFTTANVSPGLCISGDRGLAPKAGYFVQDDGEWKFTGSSYYYP 1170 (1275) T ss_dssp CSCCSSSSCSSSSCCCCCCEECCTTSCEEECCEEECCSCCCCBCCTTCCSCCCSSSCCCCSCCCBCSSSSBCCCSSBCCC T ss_pred hcCCCcccccCCCeEEEEeeeccCCeEEEEEEEecccceEEEEEEeeeEecCCceEEecCeEEEecCCEEEEeccCcccC Confidence 9999999999999999999999999999999999999999999999999994 899999999999988999999999999 Q sp|P0DTC2|SPIK 1113 QIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNHTSPDVDLG-DISGINASVVN----IQKEIDRLN 1187 (1273) Q Consensus 1113 qiittdntfvsgncdvvigivnntvydplqpeldsfkeeldkyfknhtspdvdlg-disginasvvn----iqkeidrln 1187 (1273) ..||.+|...-..|||...-+|+++..|..|++..|+|||+|+|||+++...|++ |++.+|+++++ ++.++++|+ T Consensus 1171 r~it~~d~v~~~sC~v~y~n~~~~~l~~~~p~~~df~~el~~~~~n~~~~~p~~~~~~~~~N~t~L~Ei~~l~~~~~~l~ 1250 (1275) T 6VSJ_A 1171 EPITDKNSVIMSSCAVNYTKAPEVFLNTSIPNPPDFKEELDKWFKNQTSIAPDLSLDFEKLNVTLIKRMKQIEDKIEEIE 1250 (1275) T ss_dssp CSSCCC-------------------------------------------------------------------------- T ss_pred CCCCccceEEeeccccEEEEcccccCCCCCCCCCChHHHHHHHHhcCCCCCCCcCCCHHHccHHHHHHHHHHHHHHHHHH Confidence 9999999999999999999999999999999999999999999999999666664 38899999986 666666666 Q sp|P0DTC2|SPIK 1188 EVAKNLNESLIDLQELG 1204 (1273) Q Consensus 1188 evaknlneslidlqelg 1204 (1273) ++.++||.++.++..+. T Consensus 1251 ~~i~~in~~~~~~~~~~ 1267 (1275) T 6VSJ_A 1251 SKQKKIENEIARIKKIK 1267 (1275) T ss_dssp ----------------- T ss_pred HHHHHHHHHHHHHHHhc Confidence 66777777766665543 No 7 >6VSJ_C Spike glycoprotein, Carcinoembryonic antigen-related cell; MHV spike, CEACAM1a, Complex, Glycoprotein; HET: NAG; 3.94A {Murine coronavirus (strain A59)} Probab=100.00 E-value=2.1e-195 Score=1649.54 Aligned_cols=1145 Identities=30% Similarity=0.512 Sum_probs=889.4 Template_Neff=4.000 Q sp|P0DTC2|SPIK 9 PLVSSQCVNLTTRTQLP---PAYT-----NSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAI--HVSGTNGTKR 78 (1273) Q Consensus 9 plvssqcvnlttrtqlp---payt-----nsftrgvyypdkvfrssvlhstqdlflpffsnvtwfhai--hvsgtngtkr 78 (1273) ++....|...-...-++ |.++ -+-.+|+||||..++|+..+-.|+||.+.-++.+-+-.- |... .--. T Consensus 22 ~i~~~~C~~~~~~~~~~~~~~~~s~~~idvs~~~G~yYPd~rvysN~TlL~qGLFP~~gs~~~~Y~~sgt~~~s--~~~~ 99 (1275) T 6VSJ_C 22 YIGDFRCIQLVNSNGANVSAPSISTETVEVSQGLGTYYVLDRVYLNATLLLTGYYPVDGSKFRNLALRGTNSVS--LSWF 99 (1275) T ss_dssp CCSSBCCCCCSEECCCCCCCCCCCSCBCCCTTSTTCBCCTTCBCCSCCCEEEEEEECTTCBCCBCCCEESSEEC--GGGS T ss_pred cccCcceeEeecCCCCCCCCCCCcceeeeeecceeEEEeCCeEEeceeeeeccccCCCCCceeeEEeeccCCCC--cccc Confidence 34555677653333333 3444 345689999999999999999999999998887654222 2222 1346 Q sp|P0DTC2|SPIK 79 FDNPVLPFNDGVYFASTEKSNI--------IRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVYYHKNNK 150 (1273) Q Consensus 79 fdnpvlpfndgvyfasteksni--------irgwifgttldsktqsllivnnatnvvikvcefqfcndpflgvyyhknnk 150 (1273) +++++.||+||+++...+.+|- -..++||+|.+..+++++|+++-+...|.+|.|..|..|...+++.-+|. T Consensus 100 y~~~~~~F~dGIfVkV~~~kn~t~~~~~~~ypa~~fGSTF~Nts~tvVI~P~~~~r~itvCq~~vC~~p~~~~~p~~g~~ 179 (1275) T 6VSJ_C 100 QPPYLNQFNDGIFAKVQNLKTSTPSGATAYFPTIVIGSLFGYTSYTVVIEPYNGVIMASVCQYTICQLPYTDCKPNTNGN 179 (1275) T ss_dssp STTTSCCCSSCEEEEEECCGGGSCTTCCCSSCCEEEESSCSTTSCEEEECEETTEECCEEECCCBBSSCCEESSCCCSSC T ss_pred cCCcccccCCcEEEEeeeeccCCCCcchhccceeEEecccCCCceEEEEeCCCceeEeEEEEEEEcCCCeeEEccCCCCC Confidence 7788999999999998887765 35678999999999999999999999999999999999999888744332 Q sp|P0DTC2|SPIK 151 SWMESEFRVYSSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVFKNIDGYFKIYSKHTPINL---VRDLPQGFSALEPLV 227 (1273) Q Consensus 151 swmesefrvyssannctfeyvsqpflmdlegkqgnfknlrefvfknidgyfkiyskhtpinl---vrdlpqgfsaleplv 227 (1273) +..+ ++. ....+|+|.|. +.|-+|... ..|- |.|+..||.|-+|..+...+. ..-+| |...+.+. T Consensus 180 ~~~~--~~~-~d~~nc~f~~~-~nfT~d~~~--~~~~----~~F~~~dG~fy~Yyad~~~~~~f~f~~~~-~~~~~~yy- 247 (1275) T 6VSJ_C 180 KLIG--FWH-TDVKPPICVLK-RNFTLNVNA--DAFY----FHFYQHGGTFYAYYADKPSATTFLFSVYI-GDILTQYY- 247 (1275) T ss_dssp TTCC--SSB-CCCSCCCEEEE-CCEECCTTC--SEEE----EEBCEETTEECCEECSSSSCBEECCCCCC-SSCCCEEE- T ss_pred ceee--ece-ecCCCCEEEEe-eeeccCccc--ceee----EEEEEcCCeEEEEEECCCcCcceeecccc-cceeceeE- Confidence 3322 233 67889999764 455444322 1221 999999999988876644332 11222 33333333 Q sp|P0DTC2|SPIK 228 DLPIGINITRFQTLLALHRSYLTPGDSSSGWTAGAAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFT 307 (1273) Q Consensus 228 dlpiginitrfqtllalhrsyltpgdsssgwtagaaayyvgylqprtfllkynengtitdavdcaldplsetkctlksft 307 (1273) .+-|+..++ .+.+ ..++|||++|.+|+|||+|++||.||+||||+-|+++|-||..+||. T Consensus 248 ---------------v~~~~~~~~---~~~~--~~~~~~v~~L~~~~~ll~fd~~G~i~~avDC~~~~~~el~C~~~sf~ 307 (1275) T 6VSJ_C 248 ---------------VLPFICNPT---AGST--FAPRYWVTPLVKRQYLFNFNQKGVITSAVDCASSYTSEIKCKTQSML 307 (1275) T ss_dssp ---------------ECCEECCCS---SCSC--CCCEEEEEEEEEEEEECCBCSSSCBCCCBCTTSCHHHHHHHHHTSSS T ss_pred ---------------EeeeeecCC---CCCC--cccEEEEEeccceeEEEEecCCCeEeEEEecccCccceeeeEecccc Confidence 233444333 2223 67899999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 308 VEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKL 387 (1273) Q Consensus 308 vekgiyqtsnfrvqptesivrfpnitnlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptkl 387 (1273) +++|+|++|+||+||....+|.++.+..|+|.++++|.++.++|.|.|+.++||..|+++|++..++++|+||||+|.|| T Consensus 308 ~~~GVY~~s~y~a~p~~~v~~~~~~~~~C~~~~~~~~~~~P~p~~w~R~~~~nCnfn~s~Ll~~~~~~~f~C~~ispskl 387 (1275) T 6VSJ_C 308 PSTGVYELSGYTVQPVGVVYRRVANLPACNIEEWLTARSVPSPLNWERKTFQNCNFNLSSLLRYVQAESLFCNNIDASKV 387 (1275) T ss_dssp CCSSCEECCCCCCCCCCCCCCCCCCCCBCCTHHHHTCSEEECTTSCEEEEECSCBCCHHHHHHHSEEEECCBSSCCTTTS T ss_pred CCCceeecCCeEEEeeeEEEEecCCCCCCCHHHHHhcCCCCCchhcEEeEEecCCCCHHHHHhheeeccceecCCCHHHH Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 388 NDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSK----VGGNYNYLYRLFRKSNLKP 463 (1273) Q Consensus 388 ndlcftnvyadsfvirgdevrqiapgqtgkiadynyklpddftgcviawnsnnldsk----vggnynylyrlfrksnlkp 463 (1273) .++||..|++|.|.|..+..++++||++|-|++||||+|+||+||+++|+-...+.. --++||+-|+.-++..++| T Consensus 388 ~~~CfssvtiD~F~ip~~~~~~l~~g~~g~i~~yNYkl~~~~~~C~l~~~~~~~~~~~t~~np~~~~~~~~~~~~~~f~~ 467 (1275) T 6VSJ_C 388 YGRCFGSISVDKFAVPRSRQVDLQLGNSGFLQTANYKIDTAATSCQLHYTLPKNNVTINNHNPSSWNRRYGFNDAGVFGK 467 (1275) T ss_dssp TTCCBSEEEEEEECCCSTTGGGGSTTCCSSHHHHTCCCCSSSCEEECEEEECTTTCEEECCCCCHHHHHHSCCTTTTTTT T ss_pred cccccCeeEEEEEeccchhceeecCCCCcHhHhccccCCCCCCceEEEEEcCcccccccCCCCccchhcccccccccccC Confidence 999999999999999999999999999999999999999999999999996543322 2357888888888899999 Q sp|P0DTC2|SPIK 464 FERDISTEIY--QAGSTPCNG--V------------------EGFNCYF------------PLQSYGFQPTNGVGYQPY- 508 (1273) Q Consensus 464 ferdisteiy--qagstpcng--v------------------egfncyf------------plqsygfqptngvgyqpy- 508 (1273) +++|..-..+ ..+.+-|+. . .|..|+- |..+---+|+..+||+++ T Consensus 468 ~~~dvvy~~~~~~~~~~~cpC~~~~~~~~ct~~~~~~~~~~~~~~~c~g~~vi~~~~g~~~~~~~c~c~~~af~gws~d~ 547 (1275) T 6VSJ_C 468 NQHDVVYAQQCFTVRSSFCPCAQPDIVSPCTTQTKPKSAFVNVGDHCEGLGVLEDNCGNADPHKGCICANNSFIGWSHDT 547 (1275) T ss_dssp CSSEEEEESCBBCCCSCCCSCC-----------CCCCBCCCCTTCCCCCBEECTTSEECCCSSSSCEECTTCEESEEEEE T ss_pred cccceeeccccccCCCCCCCCCCCCcCCCCCCCCCCccceeccccccceeEEeeccCCCCCCCCCccccCCcccccCccc Confidence 9999876533 233333330 0 1112211 001111256777888888 Q sp|P0DTC2|SPIK 509 -----RVVVLSFELLHA--PATVCGP---KKSTNLVKNKCVNFNFNGLTGTGVLTESN-KKFLPFQQFGRDIADTTDAVR 577 (1273) Q Consensus 509 -----rvvvlsfellha--patvcgp---kkstnlvknkcvnfnfngltgtgvltesn-kkflpfqqfgrdiadttdavr 577 (1273) |++|+|++||++ ++|||+. +..++++.++||++|..|.||+||+++.+ ..+-.+|.+..+.+.-..++| T Consensus 548 c~~~~r~~i~~~~~ln~~~s~tvCp~~~~~~~t~I~ln~CVdYNIYGitGtGVItnvt~~~~~~~qgL~yS~sG~L~~FK 627 (1275) T 6VSJ_C 548 CLVNDRCQIFANILLNGINSGTTCSTDLQLPNTEVVTGICVKYDLYGITGQGVFKEVKADYYNSWQTLLYDVNGNLNGFR 627 (1275) T ss_dssp CEETTEEEEEEEEEEESTTCCSBBCSSSCCCCCCCCCSSCEEEEETTEEEEEEEECCCCCCCCSSCCCEECTTSCEEEEE T ss_pred cccCCceeeeeeeeccCCCCCCCCCCcCCCCCceEEeCeEEEEEeCCCeeEEEEEecCCcccccCccEEEeCCCCEEEEE Confidence 999999999998 8999998 34689999999999999999999999944 444466778888889999999 Q sp|P0DTC2|SPIK 578 DPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEHVN 657 (1273) Q Consensus 578 dpqtleilditpcsfggvsvitpgtntsnqvavlyqdvnctevpvaihadqltptwrvystgsnvfqtragcligaehvn 657 (1273) ++.++++..|+||..+.++++..|. +...|+++..++|+++....+....+| .+.|+|-.||+++++|.+ T Consensus 628 n~ttg~~YsV~PC~~v~qQvVV~~~--sivgalls~n~~cs~~~~n~~~~~~~~--------~~~~~t~~gCv~~a~~~t 697 (1275) T 6VSJ_C 628 DLTTNKTYTIRSCYSGRVSAAFHKD--APEPALLYRNINCSYVFSNNISREENP--------LNYFDSYLGCVVNADNRT 697 (1275) T ss_dssp CTTTCCEEEEECCCCCEEECCCCTT--CSSCCEEETTCCHHHHHHTTCCSSCCC--------SCCEECSSSEECSCSEEE T ss_pred cCCCCCEEEEEeCceeceeEEEeCC--CceeEEEEeccceeceeeccceeeeCC--------CcceeccccceeccccCC Confidence 9999999999999999999999876 567789999999999886444333333 344999999999999887 Q sp|P0DTC2|SPIK 658 N--SYECDIPIGAGICASYQTQTNSPRRARSVASQ-SIIA---YT-MSLGAENSVAYSNNSIAIPTNFTISVTTEILPVS 730 (1273) Q Consensus 658 n--syecdipigagicasyqtqtnsprrarsvasq-siia---yt-mslgaensvaysnnsiaiptnftisvtteilpvs 730 (1273) + ..+|++|.|.|||+.+..-.-.+ |++..+ .+.. +. +..........+...|.||+||||+|++|-++++ T Consensus 698 ~~~~~~c~~~~g~giC~dg~~~~~~~---~~~~~~~~~~~~~~~~~~~~~~s~~~~~~~~~i~IP~nFtlsv~~EyiQt~ 774 (1275) T 6VSJ_C 698 DEALPNCDLRMGAGLCVDYSKSRRAH---RSVSTGYRLTTFEPYTPMLVNDSVQSVDGLYEMQIPTNFTIGHHEEFIQTR 774 (1275) T ss_dssp EEEESSCSEEETTTEEEEECTTTCSS---SSSTTSEEEEEECSCCCCBCCCSCSSSCCBCSCCBCCCCEEECCEEECCCC T ss_pred CCcCCCCCCccceEEccCcccceecc---cccCCCceeecccCCcccccCCCCCccCcceEEEccCceEEEEEEEEeecC Confidence 5 68999999999999998833222 221111 1111 11 1111125566777899999999999999999999 Q sp|P0DTC2|SPIK 731 MTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTP-P----I-KDFGGFNFSQ 804 (1273) Q Consensus 731 mtktsvdctmyicgdstecsnlllqygsfctqlnraltgiaveqdkntqevfaqvkqiyktp-p----i-kdfggfnfsq 804 (1273) |.|.+|||.+|+||++.+|.+||.|||+||..+|+||.|.+..+|....++++.+++.++.+ + | ...|+|||+. T Consensus 775 ~~kVsIDCa~YVC~g~~rC~~LL~QYgsfC~~I~~aL~~~~~~~d~~~~~~~~~~~~~~~~s~~~~~~~~~~~~~fN~s~ 854 (1275) T 6VSJ_C 775 SPKVTIDCAAFVCGDNTACRQQLVEYGSFCVNVNAILNEVNNLLDNMQLQVASALMQGVTISSRLPDGISGPIDDINFSP 854 (1275) T ss_dssp CCEEECCHHHHHSCSSHHHHHHHGGGHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTCCCCBCC---------------- T ss_pred CCCeEEEhhheecCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhccccccccCCCCCCCCCCCccchh Confidence 99999999999999999999999999999999999999999999999999999999998875 2 2 4456799999 Q sp|P0DTC2|SPIK 805 ILPD-----------PSKPSKRSFIEDLLFNKVTLADAGFIKQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQY 873 (1273) Q Consensus 805 ilpd-----------pskpskrsfiedllfnkvtladagfikqygdclgdiaardlicaqkfngltvlpplltdemiaqy 873 (1273) +||. |+++++||+|||||||||+.+|.|+.+.|.+|.+...+|||+|||.|||+.||||++++||+|.| T Consensus 855 ll~~~~~~~~~~~~~~~~~~~RSaIEDLLF~KV~t~glG~~~~Yk~Ct~g~~i~DL~CAQyyNGImVLPpvvd~~~~amY 934 (1275) T 6VSJ_C 855 LLGCIGSTCAEDGNGPSAIRGRSAIEDLLFDKVKLSDVGFVEAYNNCTGGQEVRDLLCVQSFNGIKVLPPVLSESQISGY 934 (1275) T ss_dssp ------CCSSCCSSSTTTTTTTTHHHHHHHHHCSSCTTHHHHHHHHHHTTSSTTSSHHHHHHTTCEEECCSSCHHHHHHH T ss_pred hcccccCCcccCCCCCCccCcccHHHHHHcceeeecCCchHHHHHhccCCcchHHhhcccccCcEEEeCCCCCHHHHHHH Confidence 9986 56668999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 874 TSALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVN 953 (1273) Q Consensus 874 tsallagtitsgwtfgagaalqipfamqmayrfngigvtqnvlyenqklianqfnsaigkiqdslsstasalgklqdvvn 953 (1273) |++|++|....|||+ |..||||+||.||+||+|+||+||.||||+|||.||.||+.||+.++++++||.|+||||| T Consensus 935 TasL~g~m~~gg~Ta----aaaIPFa~~vq~RlN~v~lt~~VL~~NQk~iA~sFN~A~~~iq~~f~~~~~Al~kiQ~VVN 1010 (1275) T 6VSJ_C 935 TTGATAAAMFPPWSA----AAGVPFSLSVQYRINGLGVTMNVLSENQKMIASAFNNALGAIQDGFDATNSALGKIQSVVN 1010 (1275) T ss_dssp HHHHHHTTSCSSSCS----STTCCHHHHHHHHGGGTSCHHHHTTHHHHHHHHHHHHHHHHHHHHHSSCCHHHHHHHHHHH T ss_pred HHHHHHHhhcccchh----cccCchHHHHHHHhcccccchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 999999999999997 5568999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 954 QNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECV 1033 (1273) Q Consensus 954 qnaqalntlvkqlssnfgaissvlndilsrldkveaevqidrlitgrlqslqtyvtqqliraaeirasanlaatkmsecv 1033 (1273) ++++||++|++||+.|||||||.++||++|||++||++||||||+|||.+|++||+|||+|++|+|||+.||..||.||| T Consensus 1011 ~q~~aL~~L~~qL~~nFgAISssI~dIy~RLD~leAdaQVDRLItGRL~aLnafVtQ~L~~~~evr~sr~LA~qKINECV 1090 (1275) T 6VSJ_C 1011 ANAEALNNLLNQLSNRFGAISASLQEILTRLEAVEAKAQIDRLINGRLTALNAYISKQLSDSTLIKVSAAQAIEKVNECV 1090 (1275) T ss_dssp HHHHHHHHHHHGGGSCCSSSCSCHHHHHHHSCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC T ss_pred HHHHHHHHHHHHHHHHHhHHHHHHHHHHHHHHHHHHHHHHHHHHHhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 1034 LGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDG-KAHFPREGVFVSNGTHWFVTQRNFYEP 1112 (1273) Q Consensus 1034 lgqskrvdfcgkgyhlmsfpqsaphgvvflhvtyvpaqeknfttapaichdg-kahfpregvfvsngthwfvtqrnfyep 1112 (1273) ..||+|.+|||.|.|++|+||.||+|++|+|++|+|.+.++.+++|.+|+++ ++..|+.|+|+.+...|++|.|++||| T Consensus 1091 KSQS~R~gFCGnGtHi~Si~q~APnGi~FlH~~y~Pt~~~~V~a~~GlC~~~~~~~~p~~g~fv~~n~~~~iT~r~~Y~P 1170 (1275) T 6VSJ_C 1091 KSQTTRINFCGNGNHILSLVQNAPYGLYFIHFSYVPISFTTANVSPGLCISGDRGLAPKAGYFVQDDGEWKFTGSSYYYP 1170 (1275) T ss_dssp CSCCSSSSCSSSSCCCCCCEECCTTSCEEECCEEECCSCCCCBCCTTCCSCCCSSSCCCCSCCCBCSSSSBCCCSSBCCC T ss_pred hcCCCcccccCCCeEEEEeeeccCCeEEEEEEEecccceEEEEEEeeeEecCCceEEecCeEEEecCCEEEEeccCcccC Confidence 9999999999999999999999999999999999999999999999999994 899999999999988999999999999 Q sp|P0DTC2|SPIK 1113 QIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNHTSPDVDLG-DISGINASVVN----IQKEIDRLN 1187 (1273) Q Consensus 1113 qiittdntfvsgncdvvigivnntvydplqpeldsfkeeldkyfknhtspdvdlg-disginasvvn----iqkeidrln 1187 (1273) ..||.+|...-..|||...-+|+++..|..|++..|+|||+|+|||+++...|++ |++.+|+++++ ++.++++|+ T Consensus 1171 r~it~~d~v~~~sC~v~y~n~~~~~l~~~~p~~~df~~el~~~~~n~~~~~p~~~~~~~~~N~t~L~Ei~~l~~~~~~l~ 1250 (1275) T 6VSJ_C 1171 EPITDKNSVIMSSCAVNYTKAPEVFLNTSIPNPPDFKEELDKWFKNQTSIAPDLSLDFEKLNVTLIKRMKQIEDKIEEIE 1250 (1275) T ss_dssp CSSCCC-------------------------------------------------------------------------- T ss_pred CCCCccceEEeeccccEEEEcccccCCCCCCCCCChHHHHHHHHhcCCCCCCCcCCCHHHccHHHHHHHHHHHHHHHHHH Confidence 9999999999999999999999999999999999999999999999999666664 38899999986 666666666 Q sp|P0DTC2|SPIK 1188 EVAKNLNESLIDLQELG 1204 (1273) Q Consensus 1188 evaknlneslidlqelg 1204 (1273) ++.++||.++.++..+. T Consensus 1251 ~~i~~in~~~~~~~~~~ 1267 (1275) T 6VSJ_C 1251 SKQKKIENEIARIKKIK 1267 (1275) T ss_dssp ----------------- T ss_pred HHHHHHHHHHHHHHHhc Confidence 66777777766665543 No 8 >6OHW_A Spike surface glycoprotein; Coronavirus spike glycoprotein, sialic acid; HET: MAN, NAG, BMA; 2.9A {Human coronavirus OC43} Probab=100.00 E-value=7.3e-190 Score=1602.12 Aligned_cols=1144 Identities=29% Similarity=0.505 Sum_probs=895.1 Template_Neff=3.700 Q sp|P0DTC2|SPIK 2 FVFLVLLP-----LVSSQCVNLTTRTQLP---PAYT-----NSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAI 68 (1273) Q Consensus 2 fvflvllp-----lvssqcvnlttrtqlp---payt-----nsftrgvyypdkvfrssvlhstqdlflpffsnvtwfhai 68 (1273) |+|+.|+| +....|.. ....-+. |.++ -+-.+|+||||..++++..+-.|++|.+.-++.+-.- T Consensus 13 ~~~~~~~~~~~~~i~~~~C~~-~~~~~~~~~~~~~~~~~id~s~~~G~yYp~~rvysN~tll~~glfp~~gs~~~~y~-- 89 (1322) T 6OHW_A 13 YLLGMLVASVLAVIGDLKCTS-DNINDKDTGPPPISTDTVDVTNGLGTYYVLDRVYLNTTLFLNGYYPTSGSTYRNMA-- 89 (1322) T ss_dssp ------------CCSSBCCCC-TTEECCCCCSCCEEEEECCCTTSTTCBCCTEEECCSEEEEEEEEEECTTCEEEECC-- T ss_pred HHHHHHHHHHHHHhcCccccc-cCCCCCCCCCCCCCcceeecccCceeEEecCeEEeeeeeEecceecCCCCceEEee-- Confidence 56666655 33445765 2222222 3333 3456899999999999999999999999877665321 Q sp|P0DTC2|SPIK 69 HVSGTNG---TKRFDNPVLPFNDGVYFASTEKSNIIRGW---------IFGTTLDSKTQSLLIVNNATN----------- 125 (1273) Q Consensus 69 hvsgtng---tkrfdnpvlpfndgvyfasteksniirgw---------ifgttldsktqsllivnnatn----------- 125 (1273) .+|++- --.++++..||+||++....+..|. +|| +||+|.+...++++|.++-.+ T Consensus 90 -~~~t~~~s~~~~y~~~~~~F~dGifvkv~~~~~~-t~~~~~~~yp~~~fGstf~N~s~tvVI~P~~~~~~~~~~~~~~~ 167 (1322) T 6OHW_A 90 -LKGSVLLSRLWFKPPFLSDFINGIFAKVKNTKVI-KDRVMYSEFPAITIGSTFVNTSYSVVVQPRTINSTQDGDNKLQG 167 (1322) T ss_dssp -CEESSCEEGGGGSTTTEEECSSEEEEEEECEEEE-ETTEEEEECCCEEEESSCSTTSCEEEEEEEEEC-------CCEE T ss_pred -eecccccccccccCCccccccCcEEEEEEeeccc-CCCceeeccCceEEeccccCCeeEEEEccCCCCcCccccccccc Confidence 223322 2456777889999997766655544 444 699999999999999987664 Q sp|P0DTC2|SPIK 126 -VVIKVCEFQFCNDPFLGVYYHKNNKSWMESEFRVYSSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVFKNIDGYFKIY 204 (1273) Q Consensus 126 -vvikvcefqfcndpflgvyyhknnkswmesefrvyssannctfeyvsqpflmdlegkqgnfknlrefvfknidgyfkiy 204 (1273) ..|.+|.|..|..|...+++.-+| +. -+++. ....+|+|.|. +.|-.|... ..|- |.|++.||.|-+| T Consensus 168 ~~~it~C~~~vC~~p~~~~~~~~gn-~~--~~~~~-~d~~~~~~~~~-~nfT~d~~~--~~~~----f~F~q~~G~fy~Y 236 (1322) T 6OHW_A 168 LLEVSVCQYNMCEYPQTICHPNLGN-HR--KELWH-LDTGVVSCLYK-RNFTYDVNA--DYLY----FHFYQEGGTFYAY 236 (1322) T ss_dssp EEEEEEECCCEEEEEEEECCTTTCC-SS--CCEEE-CCSSCCCEEEE-EEEEECTTC--SEEE----EEEEEETTEEEEE T ss_pred ceEEeeeeeEecCCCeeEEecCCCC-Cc--eeeeE-eecCCceEEEe-eeecccccc--ceee----EEEEEeCCeEEEE Confidence 347899999999999988875444 22 23444 66788998765 455444322 1111 9999999999887 Q sp|P0DTC2|SPIK 205 SKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHRSYLTPGDSSSGWTAGAAAYYVGYLQPRTFLLKYNENGT 284 (1273) Q Consensus 205 skhtpinlvrdlpqgfsaleplvdlpiginitrfqtllalhrsyltpgdsssgwtagaaayyvgylqprtfllkynengt 284 (1273) ..+...+. .| +...+.|...+++- .+-|+..++ ..++|||++|.+|+|||+|++||. T Consensus 237 y~d~~~~~------~f-----~f~~~~~~~~~~yy---v~p~~~~~~---------~~~~~~v~~L~~~~~Ll~fd~~G~ 293 (1322) T 6OHW_A 237 FTDTGVVT------KF-----LFNVYLGMALSHYY---VMPLTCNSK---------LTLEYWVTPLTSRQYLLAFNQDGI 293 (1322) T ss_dssp EESSSSSB------EE-----EEEEECSSCCCEEE---ECCEECSSC---------CCCCEEEEEEEEEEEEEEECTTSC T ss_pred EecCCCCc------ce-----eccccceeccceeE---eceeecCCc---------cceeEEEEeceeeeEEEEecCCCe Confidence 44432221 00 01111122222222 222333332 668999999999999999999999 Q sp|P0DTC2|SPIK 285 ITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVAD 364 (1273) Q Consensus 285 itdavdcaldplsetkctlksftvekgiyqtsnfrvqptesivrfpnitnlcpfgevfnatrfasvyawnrkrisncvad 364 (1273) ||+||||+-|+++|-||..+||.+++|+|++|+||+||...++|.+.....|+|.++++|.++.++|.|.|+.++||..| T Consensus 294 It~AvDC~~~~~sEl~C~t~sf~~~tGVY~lS~y~aqp~~~V~~~~~~~~~C~~~~~~~~~~~P~p~~w~R~~f~nCnfn 373 (1322) T 6OHW_A 294 IFNAVDCMSDFMSEIKCKTQSIAPPTGVYELNGYTVQPIADVYRRKPNLPNCNIEAWLNDKSVPSPLNWERKTFSNCNFN 373 (1322) T ss_dssp EEEEEETTSSHHHHHHHHTTCSSCCSEEEEEEEEECCCSEEEEECCSSCCBCCHHHHHTCSEEECSTTCEEEEEESCBBC T ss_pred EeEEEecccCcchhheeeecccCCCCceeecCCeEEEeeeEEEEeCCCCCCCCHHHHhcCCCCCCccceEEeEEecCCCC Confidence 99999999999999999999999999999999999999999999999988999999999999999999999999999999 Q sp|P0DTC2|SPIK 365 YSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSK 444 (1273) Q Consensus 365 ysvlynsasfstfkcygvsptklndlcftnvyadsfvirgdevrqiapgqtgkiadynyklpddftgcviawnsnnldsk 444 (1273) +++|++...+++|+||||+|.||.+.||..|++|.|.|..+..++++||.+|.|++||||+|++|+||+++|+-.+.+.. T Consensus 374 ~s~ll~~~~~~~f~C~~ispskl~~~C~ssvtiD~F~ip~~~~~~l~~g~~g~~~~~NYkl~~~~~~C~l~y~~~~~nvn 453 (1322) T 6OHW_A 374 MSSLMSFIQADSFTCNNIDAAKIYGMCFSSITIDKFAIPNGRKVDLQLGNLGYLQSFNYRIDTTATSCQLYYNLPAANVS 453 (1322) T ss_dssp HHHHHHHCEEEEEEEESSCGGGGGGCEEEEEEEEEEECCTTCGGGGSTTCCCHCCCCCCCCCSSSCEEEEEEEEEGGGCE T ss_pred HHHHhhhceeceeeecCCCHHHHcccccceeEEEEEeccCCcceeecCCCCcHHHhcCccCCCCCCceEEEEEccccccc Confidence 99999999999999999999999999999999999999999999999999999999999999999999999995554333 Q sp|P0DTC2|SPIK 445 V----GGNYNYLYRLFRKSNLKPFERDI---STEIYQ-----AGSTPCN----------G-------------------- 482 (1273) Q Consensus 445 v----ggnynylyrlfrksnlkpferdi---steiyq-----agstpcn----------g-------------------- 482 (1273) + -++||.-|+.-..+.++|.++.. ...+|. .+.+-|+ + T Consensus 454 ~t~~Nps~wn~ry~f~~~~~~~~~~~~~~~~hdvvYs~~cf~~~~~yCPC~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~ 533 (1322) T 6OHW_A 454 VSRFNPSTWNKRFGFIEDSVFKPRPAGVLTNHDVVYAQHCFKAPKNFCPCKLNGSCVGSGPGKNNGIGTCPAGTNYLTCD 533 (1322) T ss_dssp EECCCCCHHHHHTTCCHHHHSCBTTTSSBCTTEEEEESCCEECCTTCCCCBCC-----------CCBBCCCTTCCCBCC- T ss_pred cccCCccchhhccCcccccccCCCCCCcCCCcceeeeeeeecCCCCcCCCcCCCcccCCCCCCCCCCCcCCCCccccccc Confidence 2 34677777766667777765411 112222 2222121 0 Q sp|P0DTC2|SPIK 483 ----VEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFEL-----------------------------------LHAPAT 523 (1273) Q Consensus 483 ----vegfncyfplqsygfqptngvgyqpyrvvvlsfel-----------------------------------lhapat 523 (1273) ..+..|.-+...+--....|+|+++++++|++++. ...+.| T Consensus 534 ~~~~~~~~~~~~~~~~~q~~~~~gvg~~c~gl~Vi~~k~g~~~C~C~~~af~g~~~~~~~~~~~~~i~~~~~~~~~~s~t 613 (1322) T 6OHW_A 534 NLCTPDPITFTGTYKCPQTKSLVGIGEHCSGLAVKSDYCGGNSCTCRPQAFLGWSADSCLQGDKCNIFANFILHDVNSGL 613 (1322) T ss_dssp ---TTCSSSCCCSSCCSSEECCCCTTCCCCCCEECGGGEEBTTTEECGGGEESEEEEECEETTEEEEEEEEEEEEETSSS T ss_pred cCCCCCCCccccccCCCCceeeeecccccceEEEEecccCCCCccCCCccccCCCcccccCCCccccccceeecCCCCCC Confidence 01122211111111123569999999999999988 667889 Q sp|P0DTC2|SPIK 524 VCGP---KKSTNLVKNKCVNFNFNGLTGTGVLTESN-KKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVIT 599 (1273) Q Consensus 524 vcgp---kkstnlvknkcvnfnfngltgtgvltesn-kkflpfqqfgrdiadttdavrdpqtleilditpcsfggvsvit 599 (1273) ||++ +.+++++.++||++|..|.||+||+++++ ..++.++.+..|-+.-..+++++.++++..|+||..|.++++. T Consensus 614 vC~~d~~~~~snI~Ln~CVdYNIYGitGqGVItn~n~~~~~~~~GL~ydssgdL~gfKn~ttg~~YsV~PC~~g~VVGi~ 693 (1322) T 6OHW_A 614 TCSTDLQKANTDIILGVCVNYDLYGILGQGIFVEVNATYYNSWQNLLYDSNGNLYGFRDYITNRTFMIRSCYSGRVSAAF 693 (1322) T ss_dssp EEBCSSCCCCCCCCBSSEEEEEETTEEEEEEEEEECCCCCCTTEEEEECTTSCEEEEECTTTCCEEEEECCCEEEEEEEE T ss_pred cCCCcccccCceEEeCeeeeEEeCCccceEEEEecCCCceeccCcEEEcCCCCEEEEEcCCCCcEEEEEeCccCcEEEEE Confidence 9998 56799999999999999999999999964 5566778888888888889999999999999999999999998 Q sp|P0DTC2|SPIK 600 PGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEHVN--NSYECDIPIGAGICASYQTQ 677 (1273) Q Consensus 600 pgtntsnqvavlyqdvnctevpvaihadqltptwrvystgsnvfqtragcligaehvn--nsyecdipigagicasyqtq 677 (1273) ... ++..+.+|.++.|.+|....|..+++| .+-|+|-.||++++.+.. ...+|++|.|.|+|+.|.+ T Consensus 694 tS~--n~t~a~lF~n~~C~~v~~~~~~~~~~~--------~~~f~t~~Gcv~~a~~~t~~~v~~c~~~~g~~~C~~~~~- 762 (1322) T 6OHW_A 694 HAN--SSEPALLFRNIKCNYVFNNSLTRQLQP--------INYFDSYLGCVVNAYNSTAISVQTCDLTVGSGYCVDYSK- 762 (1322) T ss_dssp CTT--CSSCEEEEETCCHHHHHHTTTTTTCCC--------SCEEECSSEEEESSEEEEEEEESCCSEEEETTEEEEEC-- T ss_pred eCC--CCCccceeccceeceeeecccceeecc--------ccceeccccceecceecCCceeccccccccCceeeecCC- Confidence 765 445789999999999998766655555 233999999999999986 4889999999999999988 Q sp|P0DTC2|SPIK 678 TNSPRRARSVAS--QSIIAYTMSL-----GAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECS 750 (1273) Q Consensus 678 tnsprrarsvas--qsiiaytmsl-----gaensvaysnnsiaiptnftisvtteilpvsmtktsvdctmyicgdstecs 750 (1273) |+++++... ..+..| +.+ ........+...|.||+||||+|++|-++++|.|.+|||.+|+||++.+|. T Consensus 763 ---~~gs~~~~~~~~~l~~~-~p~~~~~v~~~~~~~~~~~~IsIP~NFTlsvt~EyIQt~~~kVsIDCa~YVC~~~~~C~ 838 (1322) T 6OHW_A 763 ---NGGSGGAITTGYRFTNF-EPFTVNSVNDSLEPVGGLYEIQIPSEFTIGNMVEFIQTSSPKVTIDCAAFVCGDYAACK 838 (1322) T ss_dssp -----------CCSEEEEEE-CCCCCEEECCCSSCBTTBEEEEEEEEEEEEEEEEEEECCCCEEEECHHHHHSCSCHHHH T ss_pred ---CCCCCceeccCceeeec-cceeecccccCCCCCcceEEEEecCceeeEEEEEEeeecCCCeEEehhheecCCCHHHH Confidence 444433222 222233 222 111223455568999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 751 NLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKT----PPIKDF--GGFNFSQILPDPS----KPSKRSFIED 820 (1273) Q Consensus 751 nlllqygsfctqlnraltgiaveqdkntqevfaqvkqiykt----ppikdf--ggfnfsqilpdps----kpskrsfied 820 (1273) +||.|||+||..+|+||.+++..+|....+++..+++-++. +.+..| |+||||.+||.+. .+++||+||| T Consensus 839 ~LL~QYgs~C~~I~~aL~~v~~~~d~~~~~~~~~~~~~~~~s~~l~~~~~~~~g~fN~s~ll~~~~s~~~~~~~RSaIED 918 (1322) T 6OHW_A 839 SQLVEYGSFCDNINAILTEVNELLDTTQLQVANSLMNGVTLSTKLKDGVNFNVDDINFSPVLGCLGSECSKASSRSAIED 918 (1322) T ss_dssp HHGGGGHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTTCEEEGGGGTCCCCEETTEECTTTCCCCCC----CCSSCHHHH T ss_pred HHHHHHHHHHHHHHHHHHHHHHhccHHHHHHHHHHhcCccccccccccccCCCCCccccccccCCCCCCCcCccccHHHH Confidence 99999999999999999999999999999999999998876 444445 6899999999875 3578999999 Q sp|P0DTC2|SPIK 821 LLFNKVTLADAGFIKQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAM 900 (1273) Q Consensus 821 llfnkvtladagfikqygdclgdiaardlicaqkfngltvlpplltdemiaqytsallagtitsgwtfgagaalqipfam 900 (1273) |||+||..+|.|+.+.|.+|.+...+|||+|||.|||+.||||++++||++.||++|++|....|||+ |..||||+ T Consensus 919 LLFnKV~tsglG~~~~Yk~Ct~g~~i~DL~CAQyyNGImVLPpVvd~~~~amYTaSL~g~m~~gg~Ta----aaaIPFa~ 994 (1322) T 6OHW_A 919 LLFDKVKLSDVGFVEAYNNCTGGAEIRDLICVQSYKGIKVLPPLLSENQFSGYTLAATSASLFPPWTA----AAGVPFYL 994 (1322) T ss_dssp HHHHTCSCSHHHHHHHHTTTTTTSCTTCHHHHHHHTTEEEECCSSCHHHHHHHHHHHHHTTTSSSCGG----GTTCCHHH T ss_pred HHcceeeeCCcchHHHhHhccCCccHHHhhccceeCcEEEeCCCCCHHHHHHHHHHHHHHhhccCchh----cccCcchH Confidence 99999999999999999999999999999999999999999999999999999999999999999997 55689999 Q sp|P0DTC2|SPIK 901 QMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDI 980 (1273) Q Consensus 901 qmayrfngigvtqnvlyenqklianqfnsaigkiqdslsstasalgklqdvvnqnaqalntlvkqlssnfgaissvlndi 980 (1273) ||.||+||+|+||+||.||||+|||.||.||+.||+.++.|++||.|+|||||++++||++|++||+.|||||||.++|| T Consensus 995 ~vq~RlN~v~lt~~VL~~NQk~iA~sFN~Ai~~iq~~f~tt~~AL~KiQ~VVN~q~~aL~~L~~qL~~nFgAISssI~DI 1074 (1322) T 6OHW_A 995 NVQYRINGLGVTMDVLSQNQKLIANAFNNALYAIQEGFDATNSALVKIQAVVNANAEALNNLLQQLSNRFGAISASLQEI 1074 (1322) T ss_dssp HHHHHHHTTTCCHHHHTTCHHHHHHHHHHHHHHHHHTTTSCCHHHHHHHHHHHHHHHHHHHHHGGGGCCTTSSCSCHHHH T ss_pred HHHHHhcccccchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhHHHHHHHHH Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 981 LSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGV 1060 (1273) Q Consensus 981 lsrldkveaevqidrlitgrlqslqtyvtqqliraaeirasanlaatkmsecvlgqskrvdfcgkgyhlmsfpqsaphgv 1060 (1273) ++|||++||++||||||+|||.+|++||+|||+|++|+|+|+.||..|+.|||..||+|.+|||.|.|++|+||.||+|+ T Consensus 1075 y~RLD~LEAdaQVDRLItGRL~aLNafVtQ~L~~~~eVr~sr~LA~qKINECVKSQS~R~gFCGnG~Hi~Si~q~AP~Gi 1154 (1322) T 6OHW_A 1075 LSRLDALEAEAQIDRLINGRLTALNAYVSQQLSDSTLVKFSAAQAMEKVNECVKSQSSRINFCGNGNHIISLVQNAPYGL 1154 (1322) T ss_dssp HHHSCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCSCCCSCSSCSTTSSEEEEEEEEETTEE T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhcccccCCCCCCeeEEEeeeccCCeE Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 1061 VFLHVTYVPAQEKNFTTAPAICHDG-KAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYD 1139 (1273) Q Consensus 1061 vflhvtyvpaqeknfttapaichdg-kahfpregvfvsngthwfvtqrnfyepqiittdntfvsgncdvvigivnntvyd 1139 (1273) +|+|.+|+|.+.++.+++|.+|++| ++..|++|+|+.+...|++|.|++|+|..||.+|...-..|||...-+|+++.. T Consensus 1155 ~F~H~~~~Pt~~~~V~a~~GlC~~~~~~~~~~~g~f~~~n~~~~~T~r~~y~Pr~~t~~d~v~~~sC~v~y~n~~~~~l~ 1234 (1322) T 6OHW_A 1155 YFIHFSYVPTKYVTARVSPGLCIAGDRGIAPKSGYFVNVNNTWMYTGSGYYYPEPITENNVVVMSTCAVNYTKAPYVMLN 1234 (1322) T ss_dssp EEEEEEEEEEEEEEEEEESCEECTTSCEEEESSEEEEEETTEEEEEETTEEEEEECCGGGEEEESSCCTTSEECTTCCCC T ss_pred EEEEeEecccceEEEEEeeeEEecCCeeEEecceEEEeeCCEEEEeccCcccCCCCCccceEEeccceeEEEEcCcccCC Confidence 9999999999999999999999995 899999999999988999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 1140 PLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNI-QKEIDRLNEVAKNLNESLIDLQELG 1204 (1273) Q Consensus 1140 plqpeldsfkeeldkyfknhtspdvdlgdisginasvvni-qkeidrlnevaknlneslidlqelg 1204 (1273) |..|++..|+|||+|+|||+++...|+.. .-+|++++|+ ++||++|++++|+|+..-.+||.+- T Consensus 1235 ~~~p~~~df~~el~~~~~n~~~~~p~~~~-~~~N~t~Lnlt~~Ei~~L~~~~~~L~~~~~el~~~I 1299 (1322) T 6OHW_A 1235 TSIPNLPDFKEELDQWFKNQTSVAPDLSL-DYINVTFLDLLIKRMKQIEDKIEEIESKQKKIENEI 1299 (1322) T ss_dssp ------------------------------------------------------------------ T ss_pred CCCCCCCChHHHHHHHHhcCCCCCCCCCc-cccccceecccHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 99999999999999999999985555543 2299999999 6999999999999999888887654 No 9 >6NZK_A Spike surface glycoprotein; Coronavirus spike glycoprotein, sialic acid; HET: MJJ, MAN, NAG, BMA; 2.8A {Human coronavirus OC43} Probab=100.00 E-value=7.3e-190 Score=1602.12 Aligned_cols=1144 Identities=29% Similarity=0.505 Sum_probs=895.1 Template_Neff=3.700 Q sp|P0DTC2|SPIK 2 FVFLVLLP-----LVSSQCVNLTTRTQLP---PAYT-----NSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAI 68 (1273) Q Consensus 2 fvflvllp-----lvssqcvnlttrtqlp---payt-----nsftrgvyypdkvfrssvlhstqdlflpffsnvtwfhai 68 (1273) |+|+.|+| +....|.. ....-+. |.++ -+-.+|+||||..++++..+-.|++|.+.-++.+-.- T Consensus 13 ~~~~~~~~~~~~~i~~~~C~~-~~~~~~~~~~~~~~~~~id~s~~~G~yYp~~rvysN~tll~~glfp~~gs~~~~y~-- 89 (1322) T 6NZK_A 13 YLLGMLVASVLAVIGDLKCTS-DNINDKDTGPPPISTDTVDVTNGLGTYYVLDRVYLNTTLFLNGYYPTSGSTYRNMA-- 89 (1322) T ss_dssp ------------CCSSBCCCC-TTEECCCCCSCCBCSSCCCCTTSTTCBCCTEEECCSEEEEEEEEECCTTCCCEECC-- T ss_pred HHHHHHHHHHHHHhcCccccc-cCCCCCCCCCCCCCcceeecccCceeEEecCeEEeeeeeEecceecCCCCceEEee-- Confidence 56666655 33445765 2222222 3333 3456899999999999999999999999877665321 Q sp|P0DTC2|SPIK 69 HVSGTNG---TKRFDNPVLPFNDGVYFASTEKSNIIRGW---------IFGTTLDSKTQSLLIVNNATN----------- 125 (1273) Q Consensus 69 hvsgtng---tkrfdnpvlpfndgvyfasteksniirgw---------ifgttldsktqsllivnnatn----------- 125 (1273) .+|++- --.++++..||+||++....+..|. +|| +||+|.+...++++|.++-.+ T Consensus 90 -~~~t~~~s~~~~y~~~~~~F~dGifvkv~~~~~~-t~~~~~~~yp~~~fGstf~N~s~tvVI~P~~~~~~~~~~~~~~~ 167 (1322) T 6NZK_A 90 -LKGSVLLSRLWFKPPFLSDFINGIFAKVKNTKVI-KDRVMYSEFPAITIGSTFVNTSYSVVVQPRTINSTQDGDNKLQG 167 (1322) T ss_dssp -CEESSCEEGGGGSTTTEEECSSEEEEEEECEEEE-ETTEEEEECCCEEEESSCSTTSCEEEEEEEEEC-------CCEE T ss_pred -eecccccccccccCCccccccCcEEEEEEeeccc-CCCceeeccCceEEeccccCCeeEEEEccCCCCcCccccccccc Confidence 223322 2456777889999997766655544 444 699999999999999987664 Q sp|P0DTC2|SPIK 126 -VVIKVCEFQFCNDPFLGVYYHKNNKSWMESEFRVYSSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVFKNIDGYFKIY 204 (1273) Q Consensus 126 -vvikvcefqfcndpflgvyyhknnkswmesefrvyssannctfeyvsqpflmdlegkqgnfknlrefvfknidgyfkiy 204 (1273) ..|.+|.|..|..|...+++.-+| +. -+++. ....+|+|.|. +.|-.|... ..|- |.|++.||.|-+| T Consensus 168 ~~~it~C~~~vC~~p~~~~~~~~gn-~~--~~~~~-~d~~~~~~~~~-~nfT~d~~~--~~~~----f~F~q~~G~fy~Y 236 (1322) T 6NZK_A 168 LLEVSVCQYNMCEYPQTICHPNLGN-HR--KELWH-LDTGVVSCLYK-RNFTYDVNA--DYLY----FHFYQEGGTFYAY 236 (1322) T ss_dssp EEEEEEECCCEEEEEEEECCTTTCC-SS--CCEEE-CCSSCCCEEEE-EEEEECTTC--SEEE----EEEEEETTEEEEE T ss_pred ceEEeeeeeEecCCCeeEEecCCCC-Cc--eeeeE-eecCCceEEEe-eeecccccc--ceee----EEEEEeCCeEEEE Confidence 347899999999999988875444 22 23444 66788998765 455444322 1111 9999999999887 Q sp|P0DTC2|SPIK 205 SKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHRSYLTPGDSSSGWTAGAAAYYVGYLQPRTFLLKYNENGT 284 (1273) Q Consensus 205 skhtpinlvrdlpqgfsaleplvdlpiginitrfqtllalhrsyltpgdsssgwtagaaayyvgylqprtfllkynengt 284 (1273) ..+...+. .| +...+.|...+++- .+-|+..++ ..++|||++|.+|+|||+|++||. T Consensus 237 y~d~~~~~------~f-----~f~~~~~~~~~~yy---v~p~~~~~~---------~~~~~~v~~L~~~~~Ll~fd~~G~ 293 (1322) T 6NZK_A 237 FTDTGVVT------KF-----LFNVYLGMALSHYY---VMPLTCNSK---------LTLEYWVTPLTSRQYLLAFNQDGI 293 (1322) T ss_dssp EESSSSSB------EE-----EEEEECSSCCCEEE---ECCEECSSC---------CCCCEEEEECEEEEEEEEECTTSC T ss_pred EecCCCCc------ce-----eccccceeccceeE---eceeecCCc---------cceeEEEEeceeeeEEEEecCCCe Confidence 44432221 00 01111122222222 222333332 668999999999999999999999 Q sp|P0DTC2|SPIK 285 ITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVAD 364 (1273) Q Consensus 285 itdavdcaldplsetkctlksftvekgiyqtsnfrvqptesivrfpnitnlcpfgevfnatrfasvyawnrkrisncvad 364 (1273) ||+||||+-|+++|-||..+||.+++|+|++|+||+||...++|.+.....|+|.++++|.++.++|.|.|+.++||..| T Consensus 294 It~AvDC~~~~~sEl~C~t~sf~~~tGVY~lS~y~aqp~~~V~~~~~~~~~C~~~~~~~~~~~P~p~~w~R~~f~nCnfn 373 (1322) T 6NZK_A 294 IFNAVDCMSDFMSEIKCKTQSIAPPTGVYELNGYTVQPIADVYRRKPNLPNCNIEAWLNDKSVPSPLNWERKTFSNCNFN 373 (1322) T ss_dssp EEEEEETTSSHHHHHHHHTTCSSCCSEEEECCCEECCCSEEEEECCSSCCBCCHHHHHTCSEEECSTTCEEEEEESCEEC T ss_pred EeEEEecccCcchhheeeecccCCCCceeecCCeEEEeeeEEEEeCCCCCCCCHHHHhcCCCCCCccceEEeEEecCCCC Confidence 99999999999999999999999999999999999999999999999988999999999999999999999999999999 Q sp|P0DTC2|SPIK 365 YSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSK 444 (1273) Q Consensus 365 ysvlynsasfstfkcygvsptklndlcftnvyadsfvirgdevrqiapgqtgkiadynyklpddftgcviawnsnnldsk 444 (1273) +++|++...+++|+||||+|.||.+.||..|++|.|.|..+..++++||.+|.|++||||+|++|+||+++|+-.+.+.. T Consensus 374 ~s~ll~~~~~~~f~C~~ispskl~~~C~ssvtiD~F~ip~~~~~~l~~g~~g~~~~~NYkl~~~~~~C~l~y~~~~~nvn 453 (1322) T 6NZK_A 374 MSSLMSFIQADSFTCNNIDAAKIYGMCFSSITIDKFAIPNGRKVDLQLGNLGYLQSFNYRIDTTATSCQLYYNLPAANVS 453 (1322) T ss_dssp HHHHHHHCEEEEEEEESSCGGGGGGCEEEEEEEEEEECCTTCGGGGSTTCCCHCCCCCCCCCSSSCEEEEEEEEEGGGCE T ss_pred HHHHhhhceeceeeecCCCHHHHcccccceeEEEEEeccCCcceeecCCCCcHHHhcCccCCCCCCceEEEEEccccccc Confidence 99999999999999999999999999999999999999999999999999999999999999999999999995554333 Q sp|P0DTC2|SPIK 445 V----GGNYNYLYRLFRKSNLKPFERDI---STEIYQ-----AGSTPCN----------G-------------------- 482 (1273) Q Consensus 445 v----ggnynylyrlfrksnlkpferdi---steiyq-----agstpcn----------g-------------------- 482 (1273) + -++||.-|+.-..+.++|.++.. ...+|. .+.+-|+ + T Consensus 454 ~t~~Nps~wn~ry~f~~~~~~~~~~~~~~~~hdvvYs~~cf~~~~~yCPC~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~ 533 (1322) T 6NZK_A 454 VSRFNPSTWNKRFGFIEDSVFKPRPAGVLTNHDVVYAQHCFKAPKNFCPCKLNGSCVGSGPGKNNGIGTCPAGTNYLTCD 533 (1322) T ss_dssp EECCCCCHHHHHTTCCHHHHSCBTTTSSBCTTEEEEESSCEECCTTEEEEECC-----------CCBBCCCTTCEEECC- T ss_pred cccCCccchhhccCcccccccCCCCCCcCCCcceeeeeeeecCCCCcCCCcCCCcccCCCCCCCCCCCcCCCCccccccc Confidence 2 34677777766667777765411 112222 2222121 0 Q sp|P0DTC2|SPIK 483 ----VEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFEL-----------------------------------LHAPAT 523 (1273) Q Consensus 483 ----vegfncyfplqsygfqptngvgyqpyrvvvlsfel-----------------------------------lhapat 523 (1273) ..+..|.-+...+--....|+|+++++++|++++. ...+.| T Consensus 534 ~~~~~~~~~~~~~~~~~q~~~~~gvg~~c~gl~Vi~~k~g~~~C~C~~~af~g~~~~~~~~~~~~~i~~~~~~~~~~s~t 613 (1322) T 6NZK_A 534 NLCTPDPITFTGTYKCPQTKSLVGIGEHCSGLAVKSDYCGGNSCTCRPQAFLGWSADSCLQGDKCNIFANFILHDVNSGL 613 (1322) T ss_dssp ---CSCSSSCCCSSCCSSEECCCCTTCCCCCCEECGGGEEBTTTEECGGGEESEEEEECEETTEEEEEEEEEEEEETSSS T ss_pred cCCCCCCCccccccCCCCceeeeecccccceEEEEecccCCCCccCCCccccCCCcccccCCCccccccceeecCCCCCC Confidence 01122211111111123569999999999999988 667889 Q sp|P0DTC2|SPIK 524 VCGP---KKSTNLVKNKCVNFNFNGLTGTGVLTESN-KKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVIT 599 (1273) Q Consensus 524 vcgp---kkstnlvknkcvnfnfngltgtgvltesn-kkflpfqqfgrdiadttdavrdpqtleilditpcsfggvsvit 599 (1273) ||++ +.+++++.++||++|..|.||+||+++++ ..++.++.+..|-+.-..+++++.++++..|+||..|.++++. T Consensus 614 vC~~d~~~~~snI~Ln~CVdYNIYGitGqGVItn~n~~~~~~~~GL~ydssgdL~gfKn~ttg~~YsV~PC~~g~VVGi~ 693 (1322) T 6NZK_A 614 TCSTDLQKANTDIILGVCVNYDLYGILGQGIFVEVNATYYNSWQNLLYDSNGNLYGFRDYITNRTFMIRSCYSGRVSAAF 693 (1322) T ss_dssp EEECSSCCCCCCCCBSSEEEEEETTEEEEEEEEEECCCCCCTTEEEEECTTSCEEEEECTTTCCEEEEECCCEECCEEEE T ss_pred cCCCcccccCceEEeCeeeeEEeCCccceEEEEecCCCceeccCcEEEcCCCCEEEEEcCCCCcEEEEEeCccCcEEEEE Confidence 9998 56799999999999999999999999964 5566778888888888889999999999999999999999998 Q sp|P0DTC2|SPIK 600 PGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEHVN--NSYECDIPIGAGICASYQTQ 677 (1273) Q Consensus 600 pgtntsnqvavlyqdvnctevpvaihadqltptwrvystgsnvfqtragcligaehvn--nsyecdipigagicasyqtq 677 (1273) ... ++..+.+|.++.|.+|....|..+++| .+-|+|-.||++++.+.. ...+|++|.|.|+|+.|.+ T Consensus 694 tS~--n~t~a~lF~n~~C~~v~~~~~~~~~~~--------~~~f~t~~Gcv~~a~~~t~~~v~~c~~~~g~~~C~~~~~- 762 (1322) T 6NZK_A 694 HAN--SSEPALLFRNIKCNYVFNNSLTRQLQP--------INYFDSYLGCVVNAYNSTAISVQTCDLTVGSGYCVDYSK- 762 (1322) T ss_dssp CTT--CSSCEEEEETCCHHHHHHTTTTTTCCC--------SCEEEETTEEEESSEEEEEEEESCCSEEEETTEEEEEC-- T ss_pred eCC--CCCccceeccceeceeeecccceeecc--------ccceeccccceecceecCCceeccccccccCceeeecCC- Confidence 765 445789999999999998766655555 233999999999999986 4889999999999999988 Q sp|P0DTC2|SPIK 678 TNSPRRARSVAS--QSIIAYTMSL-----GAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECS 750 (1273) Q Consensus 678 tnsprrarsvas--qsiiaytmsl-----gaensvaysnnsiaiptnftisvtteilpvsmtktsvdctmyicgdstecs 750 (1273) |+++++... ..+..| +.+ ........+...|.||+||||+|++|-++++|.|.+|||.+|+||++.+|. T Consensus 763 ---~~gs~~~~~~~~~l~~~-~p~~~~~v~~~~~~~~~~~~IsIP~NFTlsvt~EyIQt~~~kVsIDCa~YVC~~~~~C~ 838 (1322) T 6NZK_A 763 ---NGGSGGAITTGYRFTNF-EPFTVNSVNDSLEPVGGLYEIQIPSEFTIGNMVEFIQTSSPKVTIDCAAFVCGDYAACK 838 (1322) T ss_dssp -----------CCSEEEEEE-CCCCCEEECCCSSCBTTBEEEEEEEEEEEEEEEEEEECCCCEEEECHHHHHSCSCHHHH T ss_pred ---CCCCCceeccCceeeec-cceeecccccCCCCCcceEEEEecCceeeEEEEEEeeecCCCeEEehhheecCCCHHHH Confidence 444433222 222233 222 111223455568999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 751 NLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKT----PPIKDF--GGFNFSQILPDPS----KPSKRSFIED 820 (1273) Q Consensus 751 nlllqygsfctqlnraltgiaveqdkntqevfaqvkqiykt----ppikdf--ggfnfsqilpdps----kpskrsfied 820 (1273) +||.|||+||..+|+||.+++..+|....+++..+++-++. +.+..| |+||||.+||.+. .+++||+||| T Consensus 839 ~LL~QYgs~C~~I~~aL~~v~~~~d~~~~~~~~~~~~~~~~s~~l~~~~~~~~g~fN~s~ll~~~~s~~~~~~~RSaIED 918 (1322) T 6NZK_A 839 SQLVEYGSFCDNINAILTEVNELLDTTQLQVANSLMNGVTLSTKLKDGVNFNVDDINFSPVLGCLGSECSKASSRSAIED 918 (1322) T ss_dssp HHGGGGHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTCEEEGGGGTCCCCEETTEECTTTCCCCCC----CCSCCHHHH T ss_pred HHHHHHHHHHHHHHHHHHHHHHhccHHHHHHHHHHhcCccccccccccccCCCCCccccccccCCCCCCCcCccccHHHH Confidence 99999999999999999999999999999999999998876 444445 6899999999875 3578999999 Q sp|P0DTC2|SPIK 821 LLFNKVTLADAGFIKQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAM 900 (1273) Q Consensus 821 llfnkvtladagfikqygdclgdiaardlicaqkfngltvlpplltdemiaqytsallagtitsgwtfgagaalqipfam 900 (1273) |||+||..+|.|+.+.|.+|.+...+|||+|||.|||+.||||++++||++.||++|++|....|||+ |..||||+ T Consensus 919 LLFnKV~tsglG~~~~Yk~Ct~g~~i~DL~CAQyyNGImVLPpVvd~~~~amYTaSL~g~m~~gg~Ta----aaaIPFa~ 994 (1322) T 6NZK_A 919 LLFDKVKLSDVGFVEAYNNCTGGAEIRDLICVQSYKGIKVLPPLLSENQFSGYTLAATSASLFPPWTA----AAGVPFYL 994 (1322) T ss_dssp HHHHTCSSSHHHHHHHHHTTTTTCCTTCHHHHHHHTTEEEECCSSCHHHHHHHHHHHHHTTTSSSCGG----GTTCCHHH T ss_pred HHcceeeeCCcchHHHhHhccCCccHHHhhccceeCcEEEeCCCCCHHHHHHHHHHHHHHhhccCchh----cccCcchH Confidence 99999999999999999999999999999999999999999999999999999999999999999997 55689999 Q sp|P0DTC2|SPIK 901 QMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDI 980 (1273) Q Consensus 901 qmayrfngigvtqnvlyenqklianqfnsaigkiqdslsstasalgklqdvvnqnaqalntlvkqlssnfgaissvlndi 980 (1273) ||.||+||+|+||+||.||||+|||.||.||+.||+.++.|++||.|+|||||++++||++|++||+.|||||||.++|| T Consensus 995 ~vq~RlN~v~lt~~VL~~NQk~iA~sFN~Ai~~iq~~f~tt~~AL~KiQ~VVN~q~~aL~~L~~qL~~nFgAISssI~DI 1074 (1322) T 6NZK_A 995 NVQYRINGLGVTMDVLSQNQKLIANAFNNALYAIQEGFDATNSALVKIQAVVNANAEALNNLLQQLSNRFGAISASLQEI 1074 (1322) T ss_dssp HHHHHHHTTTCCHHHHTTCHHHHHHHHHHHHHHHHHTTTSCCHHHHHHHHHHHHHHHHHHHHHGGGGCCTTSSCSCHHHH T ss_pred HHHHHhcccccchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhHHHHHHHHH Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 981 LSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGV 1060 (1273) Q Consensus 981 lsrldkveaevqidrlitgrlqslqtyvtqqliraaeirasanlaatkmsecvlgqskrvdfcgkgyhlmsfpqsaphgv 1060 (1273) ++|||++||++||||||+|||.+|++||+|||+|++|+|+|+.||..|+.|||..||+|.+|||.|.|++|+||.||+|+ T Consensus 1075 y~RLD~LEAdaQVDRLItGRL~aLNafVtQ~L~~~~eVr~sr~LA~qKINECVKSQS~R~gFCGnG~Hi~Si~q~AP~Gi 1154 (1322) T 6NZK_A 1075 LSRLDALEAEAQIDRLINGRLTALNAYVSQQLSDSTLVKFSAAQAMEKVNECVKSQSSRINFCGNGNHIISLVQNAPYGL 1154 (1322) T ss_dssp HHHSCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCSCCCSCCSSSTTSSEEEEEEEEETTEE T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhcccccCCCCCCeeEEEeeeccCCeE Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 1061 VFLHVTYVPAQEKNFTTAPAICHDG-KAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYD 1139 (1273) Q Consensus 1061 vflhvtyvpaqeknfttapaichdg-kahfpregvfvsngthwfvtqrnfyepqiittdntfvsgncdvvigivnntvyd 1139 (1273) +|+|.+|+|.+.++.+++|.+|++| ++..|++|+|+.+...|++|.|++|+|..||.+|...-..|||...-+|+++.. T Consensus 1155 ~F~H~~~~Pt~~~~V~a~~GlC~~~~~~~~~~~g~f~~~n~~~~~T~r~~y~Pr~~t~~d~v~~~sC~v~y~n~~~~~l~ 1234 (1322) T 6NZK_A 1155 YFIHFSYVPTKYVTARVSPGLCIAGDRGIAPKSGYFVNVNNTWMYTGSGYYYPEPITENNVVVMSTCAVNYTKAPYVMLN 1234 (1322) T ss_dssp EEEEEEEEEEEEEEEEEESCEECTTSCEEEESSEEEEEETTEEEEEESSSCCEEECCGGGEEEESSCCTTSEECTTCCCC T ss_pred EEEEeEecccceEEEEEeeeEEecCCeeEEecceEEEeeCCEEEEeccCcccCCCCCccceEEeccceeEEEEcCcccCC Confidence 9999999999999999999999995 899999999999988999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 1140 PLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNI-QKEIDRLNEVAKNLNESLIDLQELG 1204 (1273) Q Consensus 1140 plqpeldsfkeeldkyfknhtspdvdlgdisginasvvni-qkeidrlnevaknlneslidlqelg 1204 (1273) |..|++..|+|||+|+|||+++...|+.. .-+|++++|+ ++||++|++++|+|+..-.+||.+- T Consensus 1235 ~~~p~~~df~~el~~~~~n~~~~~p~~~~-~~~N~t~Lnlt~~Ei~~L~~~~~~L~~~~~el~~~I 1299 (1322) T 6NZK_A 1235 TSIPNLPDFKEELDQWFKNQTSVAPDLSL-DYINVTFLDLLIKRMKQIEDKIEEIESKQKKIENEI 1299 (1322) T ss_dssp ------------------------------------------------------------------ T ss_pred CCCCCCCChHHHHHHHHhcCCCCCCCCCc-cccccceecccHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 99999999999999999999985555543 2299999999 6999999999999999888887654 No 10 >6M15_A Spike glycoprotein; VIRAL PROTEIN; HET: BMA, NAG; 2.38A {Rhinolophus bat coronavirus HKU2} Probab=100.00 E-value=6.1e-154 Score=1294.04 Aligned_cols=832 Identities=28% Similarity=0.472 Sum_probs=633.8 Template_Neff=3.500 Q sp|P0DTC2|SPIK 273 RTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYA 352 (1273) Q Consensus 273 rtfllkynengtitdavdcaldplsetkctlksftvekgiyqtsnfrvqptesivrfpnitnlcpfgevfnatrfasvya 352 (1273) -++||.|+.||+|+|++||+-+|++|-+|..++|....|.|..+++++ |+-..+|.+++ ..|+|..++||.. +++. T Consensus 216 s~~Ll~fDvNGtItdaIdC~~Sp~~eLaCsy~SFnfsdGVYpfSny~v-pkfiVYR~ssv-~nctFsN~snA~p--Si~~ 291 (1118) T 6M15_A 216 SSVLVLTDQSGAVTRYSYCADGFVNGLQCKLRLFDIPPGVYSNSEVEY-PVALYTVVHNM-SVCPQRPESYCGS--NYCP 291 (1118) T ss_dssp EEEEEEECTTSCEEEEEETTSSHHHHHHHHHTCSSCCSEEEEEEECCC-CEEEESCCSCC-EECCCCCCCCCCS--SCCC T ss_pred eeeeeeecCCCcEEEEEeccCCcccccceEeccccCCCceeccCCcee-ceEEEEEecCc-ceeecCHHhcCCC--Cccc Confidence 468999999999999999999999999999999999999999999999 99888998888 8899999999988 9999 Q sp|P0DTC2|SPIK 353 WNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYN-YKLPDDFTG 431 (1273) Q Consensus 353 wnrkrisncvadysvlynsasfstfkcygvsptklndlcftnvyadsfvirgdevrqiapgqtgkiadyn-yklpddftg 431 (1273) |.|+.++||..|+|.|. .+-+..|| |.+|. T Consensus 292 wqR~tfsNCNFNFSfLs---------------------------------------------Sdfm~SYN~y~~P~---- 322 (1118) T 6M15_A 292 FKRVVFSNCVVNYTSWT---------------------------------------------SGLLRDYQHLVLPN---- 322 (1118) T ss_dssp CCEEEECSEECCGGGGS---------------------------------------------CSCHHHHGGGBCTT---- T ss_pred cEEEEeeceeeeccEec---------------------------------------------CcchheeeeccCCC---- Confidence 99999999999999988 12222333 33343 Q sp|P0DTC2|SPIK 432 CVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEI------YQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGY 505 (1273) Q Consensus 432 cviawnsnnldskvggnynylyrlfrksnlkpferdistei------yqagstpcngvegfncyfplqsygfqptngvgy 505 (1273) | |- ++.+ .+-..|.++--.+.+-+- .....+-- |+-|...|-|+..-.|- . T Consensus 323 c----nF-nPet-Ngl~FNsl~g~Ckqsv~~--f~g~~tcCy~~VIS~~~gp~~ckG~~~geCg---------------~ 379 (1118) T 6M15_A 323 G----KF-NPFT-ECNGLNRIVDDCVTGFVL--RVGRGTAVNRTVITPYLKPNECFGWSWNDYQ---------------D 379 (1118) T ss_dssp S----CB-CSCS-EEESBCSSCCSEEECEEE--EEEEEECBTTBCCCCCCCTTEEEEEEEEETT---------------T T ss_pred C----CC-CCcc-CCcCCccccCCCccceEE--EecCceeeEEEEECCCCCCCccceeeecccc---------------c Confidence 1 10 0111 111111100000000000 00000000 01133334444433221 0 Q sp|P0DTC2|SPIK 506 QPYRVVVLSFEL-L-HAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLE 583 (1273) Q Consensus 506 qpyrvvvlsfel-l-hapatvcgpkkstnlvknkcvnfnfngltgtgvltesnkkflpfqqfgrdiadttdavrdpqtle 583 (1273) -|-..+.| - -.++|+|.. ..++++.++||++|..|.+|+||++++|..+..+|.+..+-.| ..++++ +++ T Consensus 380 ----~Vyv~~~~~g~S~~aTvCPv-d~tnI~Ld~CVdYNIYG~tGqGVItnsn~~~~~~q~GLy~ts~-L~~vk~--tg~ 451 (1118) T 6M15_A 380 ----SIYDWWIADFVSTGAFVCEK-NPDAPRTGVCITYTIEKVTFQGVLYESNFTFAQYYNVLYFGSQ-LKYVRI--LGK 451 (1118) T ss_dssp ----TEEEEEEEECCCCSCEEESS-CCCCCCTTSEEEEEETTEEEEEEEEECCCCCCTTCSEEEETTE-EEEEEE--TTE T ss_pred ----eEEeEeecCCccCCcccCCC-CCCCCccCeeEeEEeCCceeeEEEEEcCccceehhceEEEeee-eEEEEe--CCc Confidence 22333333 1 356899988 6689999999999999999999999999988888888777444 467777 999 Q sp|P0DTC2|SPIK 584 ILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEHVNN--SYE 661 (1273) Q Consensus 584 ilditpcsfggvsvitpgtntsnqvavlyqdvnctevpvaihadqltptwrvystgsnvfqtragcligaehvnn--sye 661 (1273) +..|+||..+.++++..| ++.++.|++.+||.++.+..+.. +.||-.++. -|||-.||++++...++ ..+ T Consensus 452 ~Y~V~PC~~v~qQvVv~~---~~~vglLt~S~ncn~~~~~~~~~---~~r~~~~~~--~fdt~~Gcv~~~~n~~~~~~~~ 523 (1118) T 6M15_A 452 VYEVAPCFEASYDVLFRS---SSSFGLLYRSFDCNQLRISASRF---AERLLPSHN--GTATALGCLFNATYAPNDTMVN 523 (1118) T ss_dssp EEEEECCTTSEEEEEEEE---TTEEEEEETTCCCCHHHHTSSTT---TTTCCGGGC--SEEETTEEEESSEEEEEEEESS T ss_pred EEEEecCcccceeEEEeC---CCeEEEEEcccccceeeeecccc---ccccCCCCC--CcccceeeEEEeecCCCCCCcc Confidence 999999999999999988 47899999999998887655544 334443333 39999999999987744 699 Q sp|P0DTC2|SPIK 662 CDIPIGAGICASYQTQTNSPRRARSVASQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMY 741 (1273) Q Consensus 662 cdipigagicasyqtqtnsprrarsvasqsiiaytmslgaensvaysnnsiaiptnftisvtteilpvsmtktsvdctmy 741 (1273) |+.|+|.|||+.+ .-.-.+||.+-+ .+. ... .+.....+.|.||+||||+|++|-++++|.|.+|||.+| T Consensus 524 C~~p~g~giC~dg-~~~~~~r~~~l~------~~~-~~~--v~p~~~~~~IsIPtNFTlsvt~EYIQt~~~kVsVDCa~Y 593 (1118) T 6M15_A 524 CTNPLGDGFCADL-LSNVVVRRMTFE------KHD-TTY--VAPVTNERFTELPLDHQLVLTEQFLQTTMPKFSISCETY 593 (1118) T ss_dssp CSSEEETTEEEEC-SSSCEEEEECCC------CBC-CSC--CCCCCSSEEEEEEEEEEEEEEEEEEECCCCEEEECHHHH T ss_pred CCCCceeeEecCC-cceeceeeeeee------ccc-ccc--ccCcccceeEEccCceEeEEEEEEEeccCCCeEEecchh Confidence 9999999999999 333334432222 221 111 122334477899999999999999999999999999999 Q sp|P0DTC2|SPIK 742 ICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQI-LPDPS----KPSKRS 816 (1273) Q Consensus 742 icgdstecsnlllqygsfctqlnraltgiaveqdkntqevfaqvkqiyktppikdfggfnfsqi-lpdps----kpskrs 816 (1273) +||++.+|.+||.|||+||..+|+||.+.+..+|.+..+++..+|..... +....|+||||++ +|..+ ++++|| T Consensus 594 VCngn~~C~~LL~QYgs~C~~I~~aL~~~a~led~~~~~~~s~~~~~~~~-~~~~~~~FN~S~~~lp~~~~~~~~~~~RS 672 (1118) T 6M15_A 594 ICDVSKACKNLLFRYGGFCQKIEADIRGAGVLLDSDVSGLYSTIAAKTSS-ITPTTDRFNVSQFFLPKVQSNSERFESRS 672 (1118) T ss_dssp HSSSCHHHHTTGGGSSSHHHHHHHHHHHHHHHHHHHHHHHHHHHBBCCCS-SCCBCSSCCCTTTTSCCCCCSSSCCCCCC T ss_pred ccCCCHHHHHHHHHHHHHHHHHHHHHHHHHHhhhHHHHHHHHHHhhhccC-cCCCCCCccccccccCCCCCCCccccccc Confidence 99999999999999999999999999999999999999999888766433 3366888999998 67654 346899 Q sp|P0DTC2|SPIK 817 FIEDLLFNKVTLADAGFIKQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGA--GAAL 894 (1273) Q Consensus 817 fiedllfnkvtladagfikqygdclgdiaardlicaqkfngltvlpplltdemiaqytsallagtitsgwtfga--gaal 894 (1273) +||||||+||..+|.|+.+.|.+|.+ -.+|||+|||.+||+.||||++++||++.|| +.++.||+||+ ++|. T Consensus 673 ~IEDLLF~KV~t~glG~~~~Yk~Ct~-~~i~DL~CaQyyNGimVLP~v~d~~~~amYT-----asl~ggm~~Ggit~sAa 746 (1118) T 6M15_A 673 VIEDLLFSKIETTGPGFYGDYYNCKK-NAIQDLTCAQYHNGILVIPPVMDAETLGMYG-----GIAAASLTLGIFGGQAG 746 (1118) T ss_dssp HHHHHHHHSSCCCCSSHHHHHHHHHH-HCCTTCCCCCEETTEEEECCSSCGGGCCTTS-----STTCBCSSTTTTCSSCC T ss_pred HHHHHhccceEecCCCchHhHHHhhc-chhhHHhcccccCcEEEcCCCCCHHHHHHHH-----HHHHHHHHhhhhcchhc Confidence 99999999999999999999999999 6799999999999999999999999999999 44566899988 6789 Q sp|P0DTC2|SPIK 895 QIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAIS 974 (1273) Q Consensus 895 qipfamqmayrfngigvtqnvlyenqklianqfnsaigkiqdslsstasalgklqdvvnqnaqalntlvkqlssnfgais 974 (1273) .|||||||.||+||+|+||+||.||||+|||.||.|++.||+.++.+++||.|+|||||++++||++|++||+.|||||| T Consensus 747 aiPFa~~vq~RlN~valt~~VL~~NQk~iA~sFN~A~~~iq~~f~tt~~AL~KIQ~VVN~q~~aL~~L~~QL~nnFgAIS 826 (1118) T 6M15_A 747 ITTWSLAMAGRLNALGVVQNALVDDVNKLANGFNQLTASVGKLALTTSSALQAIQAVVNQNAAQVESLVSGITENFGAIS 826 (1118) T ss_dssp CCBHHHHHHHHHHHTTSCSSCCHHHHHHHHHHHHHHHHTGGGCCTTTCHHHHHHHHHHHHHHHHHHHHHHTTTSCTTSSC T ss_pred hhhHHHHHHHHHhhhhhchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhhHHH Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 975 SVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQ 1054 (1273) Q Consensus 975 svlndilsrldkveaevqidrlitgrlqslqtyvtqqliraaeirasanlaatkmsecvlgqskrvdfcgkgyhlmsfpq 1054 (1273) |.++||++|||++||++||||||+|||.+|++||+|||+|++|+|+|+.||..|+.|||..||+|.+|||.|.|++|+|| T Consensus 827 SSI~dIy~RLD~leAdaQVDRLItGRL~aLnafVtq~l~~~~ev~~sr~LA~qKINECVKSQS~R~GFCGnGtHi~Si~q 906 (1118) T 6M15_A 827 TNFKVISQRLDKLEADVQMDRLINGRMNVLQLFVTNYKLKIAELRNTHRYVQSLINECVYAQSLRNGFCGQGLHVLSLMQ 906 (1118) T ss_dssp SCHHHHHHHBCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCSSCCCSTTTTSSSEEEEEEEE T ss_pred HHHHHHHHHHHHHHHHHHHHHHHhhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccCcccCCCCCCeEeEeecc Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 1055 SAPHGVVFLHVTYVPAQEKNFTTAPAICHD----GKAHFPREGVFVSNG-THWFVTQRNFYEPQIITTDNTFVSGNCDVV 1129 (1273) Q Consensus 1055 saphgvvflhvtyvpaqeknfttapaichd----gkahfpregvfvsng-thwfvtqrnfyepqiittdntfvsgncdvv 1129 (1273) .||+|++|+|.+|+|.+-++.+++|.+|++ +++..||+|+|+.+. +.|++|.|++|+|..||.+|.... .||+. T Consensus 907 ~APnGi~F~H~~y~Pt~~~~V~a~~GlC~~~~~~~~~~~~~~g~f~~~n~~~w~iT~r~my~Pr~it~~d~v~~-sc~v~ 985 (1118) T 6M15_A 907 NAPSGIMFFHYSLIPNNTITVKTTPGLCESDELGSKCIVAKDGVLVSANLSYWQWSPRNLYKPENLTFANVIAV-SRGAN 985 (1118) T ss_dssp EETTEEEEEEEEEEEEEEEEEEEESCEESSSSTTCCEEEESSSEEEESSCSSCEEECTTSCCCEECCTTTEEEE-CCCTT T ss_pred cCCCeEEEEEEEeccCceeEEEEeeeeEccCCCCCcEEEecccEEEEcCCCEEEECccccccCCCCCccCeEEE-ecCce Confidence 999999999999999999999999999999 457999999999864 999999999999999999998777 78999 Q sp|P0DTC2|SPIK 1130 IGIVNNTVYDPLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQY 1209 (1273) Q Consensus 1130 igivnntvydplqpeldsfkeeldkyfknhtspdvdlgdisginasvvniqkeidrlnevaknlneslidlqelgkyeqy 1209 (1273) ...+|.++..|..|++-.|+|||+|+|||+++.-.||.+.+ +|++++|++.||++|+|+.|+||+++|||++|++||+| T Consensus 986 y~~vn~t~~~p~ipd~~Df~eel~e~~kn~s~~~pdl~~~~-~N~T~LNLs~EI~~LqevIk~LN~s~IdLe~L~~~e~Y 1064 (1118) T 6M15_A 986 YTTLNRTFDIPELNSTFPIDEEFREYFQNMSSELQALKNLT-ADMSKLNISAEIQLINEIAHNVSNMRVEVEKFQRYVNY 1064 (1118) T ss_dssp CEECSSCCCC---------------------------------------------------------------------- T ss_pred EEEeccccCCCCCcCCCChHHHHHHHHhhcCccccccccce-ecCceechHHHHHHHHHHHHHHHhccccHHHhCeeeEE Confidence 99999999999999999999999999999988777787766 99999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 1210 IKWPWY 1215 (1273) Q Consensus 1210 ikwpwy 1215 (1273) |||.-. T Consensus 1065 iKW~~~ 1070 (1118) T 6M15_A 1065 VKLEVL 1070 (1118) T ss_dssp ------ T ss_pred eeceee Confidence 999854 No 11 >6M15_B Spike glycoprotein; VIRAL PROTEIN; HET: NAG, BMA; 2.38A {Rhinolophus bat coronavirus HKU2} Probab=100.00 E-value=6.1e-154 Score=1294.04 Aligned_cols=832 Identities=28% Similarity=0.472 Sum_probs=633.8 Template_Neff=3.500 Q sp|P0DTC2|SPIK 273 RTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYA 352 (1273) Q Consensus 273 rtfllkynengtitdavdcaldplsetkctlksftvekgiyqtsnfrvqptesivrfpnitnlcpfgevfnatrfasvya 352 (1273) -++||.|+.||+|+|++||+-+|++|-+|..++|....|.|..+++++ |+-..+|.+++ ..|+|..++||.. +++. T Consensus 216 s~~Ll~fDvNGtItdaIdC~~Sp~~eLaCsy~SFnfsdGVYpfSny~v-pkfiVYR~ssv-~nctFsN~snA~p--Si~~ 291 (1118) T 6M15_B 216 SSVLVLTDQSGAVTRYSYCADGFVNGLQCKLRLFDIPPGVYSNSEVEY-PVALYTVVHNM-SVCPQRPESYCGS--NYCP 291 (1118) T ss_dssp EEEEEEECTTSCEEEEEETTSSHHHHHHHHHTCSSCCSEEEEEEECCC-CEEEESCCSCC-EECCCCCCCCCCS--SCCC T ss_pred eeeeeeecCCCcEEEEEeccCCcccccceEeccccCCCceeccCCcee-ceEEEEEecCc-ceeecCHHhcCCC--Cccc Confidence 468999999999999999999999999999999999999999999999 99888998888 8899999999988 9999 Q sp|P0DTC2|SPIK 353 WNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYN-YKLPDDFTG 431 (1273) Q Consensus 353 wnrkrisncvadysvlynsasfstfkcygvsptklndlcftnvyadsfvirgdevrqiapgqtgkiadyn-yklpddftg 431 (1273) |.|+.++||..|+|.|. .+-+..|| |.+|. T Consensus 292 wqR~tfsNCNFNFSfLs---------------------------------------------Sdfm~SYN~y~~P~---- 322 (1118) T 6M15_B 292 FKRVVFSNCVVNYTSWT---------------------------------------------SGLLRDYQHLVLPN---- 322 (1118) T ss_dssp CCEEEECSEECCGGGGS---------------------------------------------CSCHHHHGGGBCTT---- T ss_pred cEEEEeeceeeeccEec---------------------------------------------CcchheeeeccCCC---- Confidence 99999999999999988 12222333 33343 Q sp|P0DTC2|SPIK 432 CVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEI------YQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGY 505 (1273) Q Consensus 432 cviawnsnnldskvggnynylyrlfrksnlkpferdistei------yqagstpcngvegfncyfplqsygfqptngvgy 505 (1273) | |- ++.+ .+-..|.++--.+.+-+- .....+-- |+-|...|-|+..-.|- . T Consensus 323 c----nF-nPet-Ngl~FNsl~g~Ckqsv~~--f~g~~tcCy~~VIS~~~gp~~ckG~~~geCg---------------~ 379 (1118) T 6M15_B 323 G----KF-NPFT-ECNGLNRIVDDCVTGFVL--RVGRGTAVNRTVITPYLKPNECFGWSWNDYQ---------------D 379 (1118) T ss_dssp S----CB-CSCS-EEESBCSSCCSEEECEEE--EEEEEECBTTBCCCCCCCTTEEEEEEEEETT---------------T T ss_pred C----CC-CCcc-CCcCCccccCCCccceEE--EecCceeeEEEEECCCCCCCccceeeecccc---------------c Confidence 1 10 0111 111111100000000000 00000000 01133334444433221 0 Q sp|P0DTC2|SPIK 506 QPYRVVVLSFEL-L-HAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLE 583 (1273) Q Consensus 506 qpyrvvvlsfel-l-hapatvcgpkkstnlvknkcvnfnfngltgtgvltesnkkflpfqqfgrdiadttdavrdpqtle 583 (1273) -|-..+.| - -.++|+|.. ..++++.++||++|..|.+|+||++++|..+..+|.+..+-.| ..++++ +++ T Consensus 380 ----~Vyv~~~~~g~S~~aTvCPv-d~tnI~Ld~CVdYNIYG~tGqGVItnsn~~~~~~q~GLy~ts~-L~~vk~--tg~ 451 (1118) T 6M15_B 380 ----SIYDWWIADFVSTGAFVCEK-NPDAPRTGVCITYTIEKVTFQGVLYESNFTFAQYYNVLYFGSQ-LKYVRI--LGK 451 (1118) T ss_dssp ----TEEEEEEEECCCCSCEEESS-CCCCCCTTSEEEEEETTEEEEEEEEECCCCCCTTCSEEEETTE-EEEEEE--TTE T ss_pred ----eEEeEeecCCccCCcccCCC-CCCCCccCeeEeEEeCCceeeEEEEEcCccceehhceEEEeee-eEEEEe--CCc Confidence 22333333 1 356899988 6689999999999999999999999999988888888777444 467777 999 Q sp|P0DTC2|SPIK 584 ILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEHVNN--SYE 661 (1273) Q Consensus 584 ilditpcsfggvsvitpgtntsnqvavlyqdvnctevpvaihadqltptwrvystgsnvfqtragcligaehvnn--sye 661 (1273) +..|+||..+.++++..| ++.++.|++.+||.++.+..+.. +.||-.++. -|||-.||++++...++ ..+ T Consensus 452 ~Y~V~PC~~v~qQvVv~~---~~~vglLt~S~ncn~~~~~~~~~---~~r~~~~~~--~fdt~~Gcv~~~~n~~~~~~~~ 523 (1118) T 6M15_B 452 VYEVAPCFEASYDVLFRS---SSSFGLLYRSFDCNQLRISASRF---AERLLPSHN--GTATALGCLFNATYAPNDTMVN 523 (1118) T ss_dssp EEEEECCTTSEEEEEEEE---TTEEEEEETTCCCCHHHHTSSTT---TTTCCGGGC--SEEETTEEEESSEEEEEEEESS T ss_pred EEEEecCcccceeEEEeC---CCeEEEEEcccccceeeeecccc---ccccCCCCC--CcccceeeEEEeecCCCCCCcc Confidence 999999999999999988 47899999999998887655544 334443333 39999999999987744 699 Q sp|P0DTC2|SPIK 662 CDIPIGAGICASYQTQTNSPRRARSVASQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMY 741 (1273) Q Consensus 662 cdipigagicasyqtqtnsprrarsvasqsiiaytmslgaensvaysnnsiaiptnftisvtteilpvsmtktsvdctmy 741 (1273) |+.|+|.|||+.+ .-.-.+||.+-+ .+. ... .+.....+.|.||+||||+|++|-++++|.|.+|||.+| T Consensus 524 C~~p~g~giC~dg-~~~~~~r~~~l~------~~~-~~~--v~p~~~~~~IsIPtNFTlsvt~EYIQt~~~kVsVDCa~Y 593 (1118) T 6M15_B 524 CTNPLGDGFCADL-LSNVVVRRMTFE------KHD-TTY--VAPVTNERFTELPLDHQLVLTEQFLQTTMPKFSISCETY 593 (1118) T ss_dssp CSSEEETTEEEEC-SSSCEEEEECCC------CBC-CSC--CCCCCSSEEEEEEEEEEEEEEEEEEECCCCEEEECHHHH T ss_pred CCCCceeeEecCC-cceeceeeeeee------ccc-ccc--ccCcccceeEEccCceEeEEEEEEEeccCCCeEEecchh Confidence 9999999999999 333334432222 221 111 122334477899999999999999999999999999999 Q sp|P0DTC2|SPIK 742 ICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQI-LPDPS----KPSKRS 816 (1273) Q Consensus 742 icgdstecsnlllqygsfctqlnraltgiaveqdkntqevfaqvkqiyktppikdfggfnfsqi-lpdps----kpskrs 816 (1273) +||++.+|.+||.|||+||..+|+||.+.+..+|.+..+++..+|..... +....|+||||++ +|..+ ++++|| T Consensus 594 VCngn~~C~~LL~QYgs~C~~I~~aL~~~a~led~~~~~~~s~~~~~~~~-~~~~~~~FN~S~~~lp~~~~~~~~~~~RS 672 (1118) T 6M15_B 594 ICDVSKACKNLLFRYGGFCQKIEADIRGAGVLLDSDVSGLYSTIAAKTSS-ITPTTDRFNVSQFFLPKVQSNSERFESRS 672 (1118) T ss_dssp HSSSCHHHHTTGGGSSSHHHHHHHHHHHHHHHHHHHHHHHHHHHBBCCCS-SCCBCSSCCCTTTTSCCCCCSSSCCCCCC T ss_pred ccCCCHHHHHHHHHHHHHHHHHHHHHHHHHHhhhHHHHHHHHHHhhhccC-cCCCCCCccccccccCCCCCCCccccccc Confidence 99999999999999999999999999999999999999999888766433 3366888999998 67654 346899 Q sp|P0DTC2|SPIK 817 FIEDLLFNKVTLADAGFIKQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGA--GAAL 894 (1273) Q Consensus 817 fiedllfnkvtladagfikqygdclgdiaardlicaqkfngltvlpplltdemiaqytsallagtitsgwtfga--gaal 894 (1273) +||||||+||..+|.|+.+.|.+|.+ -.+|||+|||.+||+.||||++++||++.|| +.++.||+||+ ++|. T Consensus 673 ~IEDLLF~KV~t~glG~~~~Yk~Ct~-~~i~DL~CaQyyNGimVLP~v~d~~~~amYT-----asl~ggm~~Ggit~sAa 746 (1118) T 6M15_B 673 VIEDLLFSKIETTGPGFYGDYYNCKK-NAIQDLTCAQYHNGILVIPPVMDAETLGMYG-----GIAAASLTLGIFGGQAG 746 (1118) T ss_dssp HHHHHHHHSSCCCCSSHHHHHHHHHH-HCCTTCCCCCEETTEEEECCSSCGGGCCTTS-----STTCBCSSTTTTCSSCC T ss_pred HHHHHhccceEecCCCchHhHHHhhc-chhhHHhcccccCcEEEcCCCCCHHHHHHHH-----HHHHHHHHhhhhcchhc Confidence 99999999999999999999999999 6799999999999999999999999999999 44566899988 6789 Q sp|P0DTC2|SPIK 895 QIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAIS 974 (1273) Q Consensus 895 qipfamqmayrfngigvtqnvlyenqklianqfnsaigkiqdslsstasalgklqdvvnqnaqalntlvkqlssnfgais 974 (1273) .|||||||.||+||+|+||+||.||||+|||.||.|++.||+.++.+++||.|+|||||++++||++|++||+.|||||| T Consensus 747 aiPFa~~vq~RlN~valt~~VL~~NQk~iA~sFN~A~~~iq~~f~tt~~AL~KIQ~VVN~q~~aL~~L~~QL~nnFgAIS 826 (1118) T 6M15_B 747 ITTWSLAMAGRLNALGVVQNALVDDVNKLANGFNQLTASVGKLALTTSSALQAIQAVVNQNAAQVESLVSGITENFGAIS 826 (1118) T ss_dssp CCBHHHHHHHHHHHTTSCSSCCHHHHHHHHHHHHHHHHTGGGCCTTTCHHHHHHHHHHHHHHHHHHHHHHTTTSCTTSSC T ss_pred hhhHHHHHHHHHhhhhhchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhhHHH Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 975 SVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQ 1054 (1273) Q Consensus 975 svlndilsrldkveaevqidrlitgrlqslqtyvtqqliraaeirasanlaatkmsecvlgqskrvdfcgkgyhlmsfpq 1054 (1273) |.++||++|||++||++||||||+|||.+|++||+|||+|++|+|+|+.||..|+.|||..||+|.+|||.|.|++|+|| T Consensus 827 SSI~dIy~RLD~leAdaQVDRLItGRL~aLnafVtq~l~~~~ev~~sr~LA~qKINECVKSQS~R~GFCGnGtHi~Si~q 906 (1118) T 6M15_B 827 TNFKVISQRLDKLEADVQMDRLINGRMNVLQLFVTNYKLKIAELRNTHRYVQSLINECVYAQSLRNGFCGQGLHVLSLMQ 906 (1118) T ss_dssp SCHHHHHHHBCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCSSCCCSTTTTSSSEEEEEEEE T ss_pred HHHHHHHHHHHHHHHHHHHHHHHhhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccCcccCCCCCCeEeEeecc Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 1055 SAPHGVVFLHVTYVPAQEKNFTTAPAICHD----GKAHFPREGVFVSNG-THWFVTQRNFYEPQIITTDNTFVSGNCDVV 1129 (1273) Q Consensus 1055 saphgvvflhvtyvpaqeknfttapaichd----gkahfpregvfvsng-thwfvtqrnfyepqiittdntfvsgncdvv 1129 (1273) .||+|++|+|.+|+|.+-++.+++|.+|++ +++..||+|+|+.+. +.|++|.|++|+|..||.+|.... .||+. T Consensus 907 ~APnGi~F~H~~y~Pt~~~~V~a~~GlC~~~~~~~~~~~~~~g~f~~~n~~~w~iT~r~my~Pr~it~~d~v~~-sc~v~ 985 (1118) T 6M15_B 907 NAPSGIMFFHYSLIPNNTITVKTTPGLCESDELGSKCIVAKDGVLVSANLSYWQWSPRNLYKPENLTFANVIAV-SRGAN 985 (1118) T ss_dssp EETTEEEEEEEEEEEEEEEEEEEESCEESSSSTTCCEEEESSSEEEESSCSSCEEECTTSCCCEECCTTTEEEE-CCCTT T ss_pred cCCCeEEEEEEEeccCceeEEEEeeeeEccCCCCCcEEEecccEEEEcCCCEEEECccccccCCCCCccCeEEE-ecCce Confidence 999999999999999999999999999999 457999999999864 999999999999999999998777 78999 Q sp|P0DTC2|SPIK 1130 IGIVNNTVYDPLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQY 1209 (1273) Q Consensus 1130 igivnntvydplqpeldsfkeeldkyfknhtspdvdlgdisginasvvniqkeidrlnevaknlneslidlqelgkyeqy 1209 (1273) ...+|.++..|..|++-.|+|||+|+|||+++.-.||.+.+ +|++++|++.||++|+|+.|+||+++|||++|++||+| T Consensus 986 y~~vn~t~~~p~ipd~~Df~eel~e~~kn~s~~~pdl~~~~-~N~T~LNLs~EI~~LqevIk~LN~s~IdLe~L~~~e~Y 1064 (1118) T 6M15_B 986 YTTLNRTFDIPELNSTFPIDEEFREYFQNMSSELQALKNLT-ADMSKLNISAEIQLINEIAHNVSNMRVEVEKFQRYVNY 1064 (1118) T ss_dssp CEECSSCCCC---------------------------------------------------------------------- T ss_pred EEEeccccCCCCCcCCCChHHHHHHHHhhcCccccccccce-ecCceechHHHHHHHHHHHHHHHhccccHHHhCeeeEE Confidence 99999999999999999999999999999988777787766 99999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 1210 IKWPWY 1215 (1273) Q Consensus 1210 ikwpwy 1215 (1273) |||.-. T Consensus 1065 iKW~~~ 1070 (1118) T 6M15_B 1065 VKLEVL 1070 (1118) T ss_dssp ------ T ss_pred eeceee Confidence 999854 No 12 >6JX7_A Feline Infectious Peritonitis Virus Spike; CoV spike protein, VIRAL PROTEIN; HET: NAG, MAN, FUC, BMA; 3.31A {Feline infectious peritonitis virus} Probab=100.00 E-value=2e-132 Score=1149.25 Aligned_cols=664 Identities=33% Similarity=0.532 Sum_probs=532.7 Template_Neff=4.600 Q sp|P0DTC2|SPIK 525 CGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVITPGTN- 603 (1273) Q Consensus 525 cgpkkstnlvknkcvnfnfngltgtgvltesnkkflpfqqfgrdiadttdavrdpqtleilditpcsfggvsvitpgtn- 603 (1273) -|-...++++.++||++|.-|.+|+|++++++..+... .+-.|...-.++.++..++++..|+||....++|+..|+. T Consensus 674 ~g~~d~~~i~l~~Cv~YnIYG~tG~GvI~~~~~~~~~G-l~~~s~sG~l~~Fk~~~~~~~Y~V~PC~~~~Q~vV~~~~iV 752 (1468) T 6JX7_A 674 LGFQDISNIVKDECTDYNIYGFQGTGIIRSTTSRLVAG-LYYTSASGDLLGFKISTTGEIFTVVPCDLTAQAAVINDEIV 752 (1468) T ss_dssp CSCSSCCCCCBSSEEEEEETTEEEEEEEEECCCCCCSC-SEEECTTSCEEEEECSSSSCEEEEECSSCCEEEEESSSSEE T ss_pred ceeeccceeEeccceeEEeCCccceEEEEecCeeeeCc-EEEEcCCCCEEEEEeCCCCCEEEEEeCCcCceEEEECCeEE Confidence 34456789999999999999999999999999888655 6667777778999999999999999999999999999875 Q sp|P0DTC2|SPIK 604 ---TSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEHVNNSYECDIPIGAGICASYQTQTNS 680 (1273) Q Consensus 604 ---tsnqvavlyqdvnctevpvaihadqltptwrvystgsnvfqtragcligaehvnnsyecdipigagicasyqtqtns 680 (1273) ||...+.+++.+||+++..+.+ .++. ..+.++|-.||.+++.+...+.+|+.++|.|.|+-+.+-. T Consensus 753 G~ltS~n~~~~~~~~nct~v~~s~~---s~~~------~~~~~~TP~fcy~~~~~~~~~~~c~~~l~yg~~~i~~dG~-- 821 (1468) T 6JX7_A 753 GAITATNQTDLFEFVNHTWSRSARG---SSPS------TVNTYTMPQFYYITKWNNGTSSNCTSVITYSSFAICNTGE-- 821 (1468) T ss_dssp EEEESSSCCCSSSCSCC--------------C------CCCEEECSSCEEECSCCSSSCCCCCCCBCCTTEEECTTSC-- T ss_pred EEEEccCcccccccceeeeeeeecc---CCCC------cccceecceeEEEeeccCCccccccceeeeceEEEcCCCc-- Confidence 7788889999999999884433 1111 3455999999999999888899999999999888776621 Q sp|P0DTC2|SPIK 681 PRRARSVASQSIIAYTMSLGAE-NS--VAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYG 757 (1273) Q Consensus 681 prrarsvasqsiiaytmslgae-ns--vaysnnsiaiptnftisvtteilpvsmtktsvdctmyicgdstecsnlllqyg 757 (1273) .+-+ -...+++... .. ..-....|.||+||||+|++|-+.++|.|.+|||.+|+||++.+|.+||.||| T Consensus 822 ---i~~v-----~~~~~~~~~~~~~~~~~~~t~~v~IP~nFt~~v~~EyiQ~~~~kv~idC~~YVC~~~~~C~~ll~qYg 893 (1468) T 6JX7_A 822 ---IKYV-----NVTHVEIVDDSVGVIKPVSTGNITIPKNFTVAVQAEYVQIQVKPVAVDCAKYVCNGNRHCLNLLTQYT 893 (1468) T ss_dssp ---EEEC-----CCEECSSSSCSSSSCCCCCSSEEECCCCEEEEEEEEEECCCCCCEEECHHHHHSSSCHHHHTTGGGGH T ss_pred ---EEEE-----eceeeeeeeCccccccceeEEEEEecCCeeEEEEEEEEeccCCceEEechhhhcCCCHHHHHHHHHHh Confidence 1111 0000111000 00 11123478999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 758 SFCTQLNRALTGIAVEQDKNTQEVFAQVKQ-IYKTPPIKDFG-------------GFNFSQILPDPSKPSKRSFIEDLLF 823 (1273) Q Consensus 758 sfctqlnraltgiaveqdkntqevfaqvkq-iyktppikdfg-------------gfnfsqilpdpskpskrsfiedllf 823 (1273) +||..+++||.+.+ .+|......+..+.. -++++-+.+|. ++|++.+||.+. ++||+|||||| T Consensus 894 s~C~~I~~al~~~~-~ld~~~~~~~~~~~~~~~~~~~~~~fn~~~~~~~~~g~~~~~~~s~~l~~~~--~~RS~IEDLLF 970 (1468) T 6JX7_A 894 SACQTIENSLNLGA-RLESLMLNDMITVSDRSLEFATVDKFNTTALGGEKLGGLYFDGLSSLLPPRV--GMRSAVEDLLF 970 (1468) T ss_dssp HHHHHHHHHHHHHH-HHHHHHHTTTCEECHHHHTTCSTTTTTSCCSSSCCSSCTTHHHHHHHSCSSS--SSCCHHHHHHT T ss_pred HHHHHHHHHHHHHH-HHHHHhHhhcceeccccccccCcccccCcccCcccccccccCCcccCCCCCC--CCCcHHHHHhc Confidence 99999999999988 666443334444332 44555565553 267787787654 79999999999 Q sp|P0DTC2|SPIK 824 NKVTLADAGFIK-QYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAMQM 902 (1273) Q Consensus 824 nkvtladagfik-qygdclgdiaardlicaqkfngltvlpplltdemiaqytsallagtitsgwtfgagaalqipfamqm 902 (1273) +||..+|.|+++ .|.+|.+...+|||+|||.+||+.||||++++||++.||++|++|....|||. |..||||+|| T Consensus 971 ~KV~t~glg~vd~~Y~~C~~g~~i~DL~CaQ~yNGi~VLP~v~~~~~~a~YT~sl~g~m~~gg~t~----aaaiPFa~~v 1046 (1468) T 6JX7_A 971 NKVVTSGLGTVDDDYKKCSAGTDVADLVCAQYYNGIMVLPGVVDYNKMAMYTASLIGGMALGSITS----AVAVPFSMQV 1046 (1468) T ss_dssp TTTTTTTCCCCCCCSTTTTTCSSSCCHHHHHHHTTEEECCCSSCHHHHHHHHHHHHHHHHCCCTTC----CCCCCHHHHH T ss_pred ccEEecCCCcCCHHHHHccCCccHHHHhCccccCeEEEeCCCCCHHHHHHHHHHHHHHHHhcchhh----eecccHHHHH Confidence 999999999999 69999999999999999999999999999999999999999999999999996 6679999999 Q sp|P0DTC2|SPIK 903 AYRFNGIGVTQNVLYENQKLIANQFNSAIGKI--------------QDSLSSTASALGKLQDVVNQNAQALNTLVKQLSS 968 (1273) Q Consensus 903 ayrfngigvtqnvlyenqklianqfnsaigki--------------qdslsstasalgklqdvvnqnaqalntlvkqlss 968 (1273) .+|+|++|+||+||.||||+|||.||.|||.| |+.++++++||.|+|||||++++||++|++||+. T Consensus 1047 q~RlN~v~lt~~vL~~NQk~iA~sFN~A~~~it~af~~v~~ai~~t~~gf~t~~~Al~kiQ~VVN~q~~aL~~l~~qL~~ 1126 (1468) T 6JX7_A 1047 QARLNYVALQTDVLQENQKILANAFNNAIGNITLALGKVSNAITTVSDGFNSMASALTKIQSVVNQQGEALSHLISQLQK 1126 (1468) T ss_dssp HHHHHTTSCCCSCCHHHHHHHHHHHHHHHHHHHHHHHSCCSCSCCCCSHHHHHHHHHHHHHHHTTTHHHHHHHHHGGGSC T ss_pred HHHhhhhhhchHHHHHHHHHHHHHHHHHHHHHHHHhhhhhhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 99999999999999999999999999999999 6668999999999999999999999999999999 Q sp|P0DTC2|SPIK 969 NFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYH 1048 (1273) Q Consensus 969 nfgaissvlndilsrldkveaevqidrlitgrlqslqtyvtqqliraaeirasanlaatkmsecvlgqskrvdfcgkgyh 1048 (1273) |||||||.++||.+|||++||++|+||||+|||.+|++||+|+|+|++|+|+|+.||..|+.|||..||+|.+|||.|.| T Consensus 1127 nFgAISssi~dIy~rLd~leAdaQvDRLItGRL~aLna~vtq~l~~~~~v~~sr~LA~qKinECVksQS~R~gFCGnG~H 1206 (1468) T 6JX7_A 1127 NFQAISSSIAEIYNRLEKVEADAQVDRLITGRLAALNAYVAQTLTQYAEVKASRQLAMEKVNECVKSQSDRYGFCGNGTH 1206 (1468) T ss_dssp CTTSSCSCHHHHTTTSCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCTTCCCCTTSSSSSSE T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHccccccCCCCCCee Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 1049 LMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDG-KAHFPRE--GVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGN 1125 (1273) Q Consensus 1049 lmsfpqsaphgvvflhvtyvpaqeknfttapaichdg-kahfpre--gvfvsngthwfvtqrnfyepqiittdntfvsgn 1125 (1273) ++|+||.||.|++|+|.+|+|.+-++.+++|.+|+++ ++..||+ ++|+.+...|++|.|++|||..||.+|...-.. T Consensus 1207 v~S~~q~APnGi~F~H~~~~Pt~~~~v~a~~GlC~~~~~~~~~~~~~~~~~~~n~~~~~T~r~~y~Pr~~t~~d~v~~~s 1286 (1468) T 6JX7_A 1207 LFSLVNSAPDGLLFFHTVLLPTEWEEVTAWSGICVNDTYAYLLKDFDHSIFSYNGTYMVTPRNMFQPRKPQMSDFVQITS 1286 (1468) T ss_dssp EEEEEEEETTEEEEEEEEEEECCCCEEECBSCEEETTTEEEEESSSSEEEEESSSCEEEEESSSCCCBCCCGGGEEEESC T ss_pred eEeeeecCCCeEEEEEEEeccCceEEEEEEEEEeecCCeeEEeecCceEEEeeCCEEEEeccccccCCCCCccceEEeec Confidence 9999999999999999999999999999999999995 7889998 999998889999999999999999999999999 Q sp|P0DTC2|SPIK 1126 CDVVIGIVNNTVYDPLQPEL----DSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRL--------------N 1187 (1273) Q Consensus 1126 cdvvigivnntvydplqpel----dsfkeeldkyfknhtspdvdlgdisginasvvniqkeidrl--------------n 1187 (1273) |||...-++.++..+..|++ +.|+|||++++|||++|+.++.. ..+|+++.||+.||++| + T Consensus 1287 C~v~y~n~~~~~~~~~~p~~~d~n~~~~~~~~~~~~n~t~~~~~~~~-~~~n~t~Lnl~~Ei~~l~~~~~~l~~~~~~~~ 1365 (1468) T 6JX7_A 1287 CEVTFLNTTHTTFQEIVIDYIDINKTIADMLEQYHSNYTTPELDLQL-EIFNQTKLNLTAEIDQLEQRADNLTNIAHELQ 1365 (1468) T ss_dssp CCTTSEEECHHHHHHHSTTCCCHHHHHHHHHHHHTC-------------------------------------------- T ss_pred CeeEEEEcccccccccccCccccCHhHHHHHHHhcCCCCCcccccCc-cccccceecHHHHHHHHHHHHHHHHHHHHHHH Confidence 99999999999999999999 99999999999999999997765 88999999999999997 9 Q sp|P0DTC2|SPIK 1188 EVAKNLNESLIDLQELGKYEQYIKWPWYI 1216 (1273) Q Consensus 1188 evaknlneslidlqelgkyeqyikwpwyi 1216 (1273) |+.|+||+++|||++|++||+||||||.- T Consensus 1366 ~~i~~lN~s~idLe~L~~~e~YiKWPW~~ 1394 (1468) T 6JX7_A 1366 QYIDNLNKTIVDLEWLNRIETYVKWPGSG 1394 (1468) T ss_dssp ----------------------------- T ss_pred HHHHHHHhcCccHHHHceeEeEecCcccc Confidence 99999999999999999999999999963 No 13 >5SZS_A Spike glycoprotein; coronavirus, viral fusion protein, vaccine; HET: MAN, NAG, BMA; 3.4A {Human coronavirus NL63} Probab=100.00 E-value=7.1e-131 Score=1128.95 Aligned_cols=662 Identities=31% Similarity=0.515 Sum_probs=529.3 Template_Neff=4.500 Q sp|P0DTC2|SPIK 505 YQPYRVVVLSFE----LLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQ 580 (1273) Q Consensus 505 yqpyrvvvlsfe----llhapatvcgpkkstnlvknkcvnfnfngltgtgvltesnkkflpfqqfgrdiadttdavrdpq 580 (1273) ++.+..|-+++. ...+|..+.|-...+++..++||++|.-|.+|+|++++++..+...+.+ .+.+.-..++++.. T Consensus 575 ~~~~~~VYVt~s~GsrItgv~~p~~g~~d~~~i~l~~CvdYnIYG~tG~GvI~n~n~~~~~Gl~~-tS~sg~l~~fk~~~ 653 (1325) T 5SZS_A 575 YTIVGALYVTWSEGNSITGVPYPVSGIREFSNLVLNNCTKYNIYDYVGTGIIRSSNQSLAGGITY-VSNSGNLLGFKNVS 653 (1325) T ss_dssp EEEEEEEEECCEEEEEEEECSSCCCSCSSCCBCCCSSCEEEEETTEEEEEEEEEECCCCCSCSEE-ECTTSCEEEEECTT T ss_pred EEEEEEEEEEecCCCeeEcccccccceeccceEEeCeeeeeEeCCccceeEEEeeceeeeCCEEE-EcCCCCEEEEEcCC Confidence 666677777765 5556666888888999999999999999999999999999999888888 78888888999999 Q sp|P0DTC2|SPIK 581 TLEILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTRAG-CLIGAEHVNN- 658 (1273) Q Consensus 581 tleilditpcsfggvsvitpgtntsnqvavlyqdvnctevpvaihadqltptwrvystgsnvfqtrag-cligaehvnn- 658 (1273) ++++..|+||..+.++|+..|+. ..+.+ ..|++.-+ ..|.|+|-.| |..++++.-+ T Consensus 654 ~g~~Y~V~PC~~~~Q~VV~~g~~---vGalt--s~n~~~~~-----------------fnn~~~t~~~~~~s~~~~n~t~ 711 (1325) T 5SZS_A 654 TGNIFIVTPCNQPDQVAVYQQSI---IGAMT--AVNESRYG-----------------LQNLLQLPNFYYVSNGGNNCTT 711 (1325) T ss_dssp SSCEEEEECSSCCEEEEEETTEE---EEEEE--SSSSCCSS-----------------CCEEEEETTEEEEESCCSCCSC T ss_pred CCCEEEEEeCCCCCeEEEECCce---eEEEE--ceeceecC-----------------CCcceecCCcEEEecCCcccCC Confidence 99999999999999999998762 22222 22222111 3467778888 7777644433 Q sp|P0DTC2|SPIK 659 -SYECDIPIGAGICASYQTQTNSPRRARSVASQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVD 737 (1273) Q Consensus 659 -syecdipigagicasyqtqtnsprrarsvasqsiiaytmslgaensvaysnnsiaiptnftisvtteilpvsmtktsvd 737 (1273) ..+| .|.|||+.+......|++. ....+ .. -....|.||+|||++|++|-++.+|.|.+|| T Consensus 712 ~v~ty---~~~giC~dg~~~~~~~~~~---~~~~~--------~~----~~t~~i~IP~nft~~v~~EyiQ~~~~kv~iD 773 (1325) T 5SZS_A 712 AVMTY---SNFGICADGSLIPVRPRNS---SDNGI--------SA----IITANLSIPSNWTTSVQVEYLQITSTPIVVD 773 (1325) T ss_dssp EEEEE---TTEEEETTSCEEECCCCBC---CCCCC--------CC----SSSEEEEEEEEEEEEEEEEEEECCCCCEEEC T ss_pred cchhc---ccceEeeCCCccccccccC---CCCCc--------ee----ceeeeEEccCceEEEEEEEEeeccCCCeEEe Confidence 3455 8999999998775555321 11111 00 1112799999999999999999999999999 Q sp|P0DTC2|SPIK 738 CTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVK---QIYKTPPIKDFGGFNFSQILPDPSKP-- 812 (1273) Q Consensus 738 ctmyicgdstecsnlllqygsfctqlnraltgiaveqdkntqevfaqvk---qiyktppikdfggfnfsqilpdpskp-- 812 (1273) |.+|+||++.+|.+||.|||+||..+++||.+.+..++. |++..++ +.+..+.+..|++|||+.+||.+..+ T Consensus 774 C~~YVC~~~~~C~~ll~qYgs~C~~I~~al~~~~~~~~~---~~~~~~~~~~~~~~~~~~~~~~~~n~s~~l~~~~~~~~ 850 (1325) T 5SZS_A 774 CATYVCNGNPRCKNLLKQYTSACKTIEDALRLSAHLETN---DVSSMLTFDSNAFSLANVTSFGDYNLSSVLPQRNIRSS 850 (1325) T ss_dssp TTTTTSTTCTTHHHHGGGGHHHHHHHHHHHHHHHHHHHH---HHHHHCCBCHHHHHHTCGGGTGGGCCTTTSCCSCCSSS T ss_pred chhhccCCCHHHHHHHHHHhHHHHHHHHHHHHHHHHhhH---HHHhhhccCCcccccccccccCCCcchhccCCCCCCCc Confidence 999999999999999999999999999999999988754 4444444 34455678999999999999998754 Q sp|P0DTC2|SPIK 813 --SKRSFIEDLLFNKVTLADAGFIK-QYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFG 889 (1273) Q Consensus 813 --skrsfiedllfnkvtladagfik-qygdclgdiaardlicaqkfngltvlpplltdemiaqytsallagtitsgwtfg 889 (1273) +.||+||||||+||..+|.|+++ .|..|.+...+|||+|||.+||+.||||++++||+|.||++|++|....|||. T Consensus 851 ~~~~RS~IEDLLF~KV~t~glg~vd~~Y~~C~~g~~i~DL~CaQ~yNGi~VLP~v~~~~~~a~YT~sl~g~m~~gg~ta- 929 (1325) T 5SZS_A 851 RIAGRSALEDLLFSKVVTSGLGTVDVDYKSCTKGLSIADLACAQYYNGIMVLPGVADAERMAMYTGSLIGGMVLGGLTS- 929 (1325) T ss_dssp CSCCCCHHHHHHHHHHC-------CCCGGGGGSCSSCCCHHHHHHTTTEEECCCSSCHHHHHHHHHHHHHTTTCCSBST- T ss_pred ccCcccHHHHHHCCceeecCCCccchhhHHccCCccHHHHhcccccCeEEEeCCCCCHHHHHHHHHHHHHHHHhhchHH- Confidence 89999999999999999999997 99999999999999999999999999999999999999999999999999997 Q sp|P0DTC2|SPIK 890 AGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDS--------------LSSTASALGKLQDVVNQN 955 (1273) Q Consensus 890 agaalqipfamqmayrfngigvtqnvlyenqklianqfnsaigkiqds--------------lsstasalgklqdvvnqn 955 (1273) |..||||+||.+|+||+|+||+||.||||+|||.||.|||.||.. ++++|+||.|+|||||++ T Consensus 930 ---aaaiPFa~~vq~RlN~v~lt~~VL~~NQk~iA~sFN~A~~~i~~~f~~vn~ai~qts~~~~tv~~Al~kiQ~VVN~q 1006 (1325) T 5SZS_A 930 ---AAAIPFSLALQARLNYVALQTDVLQENQKILAASFNKAINNIVASFSSVNDAITQTAEAIHTVTIALNKIQDVVNQQ 1006 (1325) T ss_dssp ---TCCCCHHHHHHHHHHTTSCCCCSSCHHHHHHHHHHHHHHHHHHHHHHC--------CTHHHHHHHHHHHHHHHHHHH T ss_pred ---hhhChHHHHHHHHhhHhhhcHHHHHHHHHHHHHHHHHHHHHHHHHHHhhHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 556899999999999999999999999999999999999999988 445669999999999999 Q sp|P0DTC2|SPIK 956 AQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLG 1035 (1273) Q Consensus 956 aqalntlvkqlssnfgaissvlndilsrldkveaevqidrlitgrlqslqtyvtqqliraaeirasanlaatkmsecvlg 1035 (1273) ++||++|++||+.|||||||.++||.+|||++||++|+||||+|||.+|++||+|+|.|++|+|+|+.||..|+.|||.. T Consensus 1007 ~~aL~~l~~qL~~nFgAISssi~dIy~rLd~leAdaQvDRLItGRL~aLna~vtq~l~~~~~v~~sr~LA~qKinECVks 1086 (1325) T 5SZS_A 1007 GSALNHLTSQLRHNFQAISNSIQAIYDRLDSIQADQQVDRLITGRLAALNAFVSQVLNKYTEVRGSRRLAQQKINECVKS 1086 (1325) T ss_dssp HHHHHHHHHGGGCCCSSSCSCHHHHHTTSCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHc Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 1036 QSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDG-KAHFPREGVFVS--NGTHWFVTQRNFYEP 1112 (1273) Q Consensus 1036 qskrvdfcgkgyhlmsfpqsaphgvvflhvtyvpaqeknfttapaichdg-kahfpregvfvs--ngthwfvtqrnfyep 1112 (1273) ||+|.+|||.|.|++|+||.||+|++|+|.+|+|.+-++.+++|.+|+++ ++..||++.|+- +...|++|.|++||| T Consensus 1087 QS~R~gFCGnG~Hi~S~~q~APnGi~F~H~~~~Pt~~~~v~a~~GlC~~~~~~~~~~~~~~v~~~~n~~~~~T~r~~y~P 1166 (1325) T 5SZS_A 1087 QSNRYGFCGNGTHIFSIVNSAPDGLLFLHTVLLPTDYKNVKAWSGICVDGIYGYVLRQPNLVLYSDNGVFRVTSRVMFQP 1166 (1325) T ss_dssp CCCCTTSSSSSEEEEEEEEEETTEEEEEEEEEEEEEEEEEEEESCEEETTTEEEEESSTTEEEEEETTEEEEEESSSCCC T ss_pred cCcCcCCCCCCeeeEEeeecCCCeEEEEEEeecccceeEEEEEEEEeecCCeeEEecCCCeEEEecCCEEEEeccccccC Confidence 99999999999999999999999999999999999999999999999995 789999996655 777999999999999 Q sp|P0DTC2|SPIK 1113 QIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNHTSPD-VDLGDISGINASVVNIQKEIDR------ 1185 (1273) Q Consensus 1113 qiittdntfvsgncdvvigivnntvydplqpeldsfkeeldkyfknhtspd-vdlgdisginasvvniqkeidr------ 1185 (1273) ..||.++...-..|||...-++.++..+..|+.-.|++||+|+||++++.. .|+ ++..+|+.+.|+..||++ T Consensus 1167 r~~t~~d~v~~~sc~v~y~n~~~~~~~~~~p~~~d~~~el~~~~~~~~~~~~p~~-~~~~~n~t~lnl~~ei~~L~~~~~ 1245 (1325) T 5SZS_A 1167 RLPVLSDFVQIYNCNVTFVNISRVELHTVIPDYVDVNKTLQEFAQNLPKYVKPNF-DLTPFNLTYLNLSSELKQLEAKTA 1245 (1325) T ss_dssp BCCCGGGEEECSCCCSSSEEECTTGGGGTSTTCCCHHHHHHHC------------------------------------- T ss_pred cCCCccceEEeeccceEEEEccceecCCCCCCCCChHHHHHHHHHcCCCCCCCCC-CcccccceecchHHHHHHHHHHHh Confidence 999999999999999999999999999999999999999999999987655 455 378899999999999999 Q sp|P0DTC2|SPIK 1186 --------LNEVAKNLNESLIDLQELGKYEQYIKWPWY 1215 (1273) Q Consensus 1186 --------lnevaknlneslidlqelgkyeqyikwpwy 1215 (1273) |+++.|+||+++|||++|++||+||||--- T Consensus 1246 ~l~~~~~~l~~~i~~lN~s~idLe~L~~~e~YiKW~~~ 1283 (1325) T 5SZS_A 1246 SLFQTTVELQGLIDQINSTYVDLKLLNRFENLIKRMKQ 1283 (1325) T ss_dssp -------------------------------------- T ss_pred hHHHHHHHHHHHHHHHHHhccCHHHhcHHHHHHHHHHH Confidence 999999999999999999999999999643 No 14 >6IXB_B Spike glycoprotein; Alphacoronavirus, spike glycoprotein, STRUCTURAL PROTEIN; HET: MAN, NAG, BMA;{Human coronavirus 229E} Probab=100.00 E-value=8.3e-129 Score=1101.71 Aligned_cols=647 Identities=34% Similarity=0.594 Sum_probs=512.2 Template_Neff=4.700 Q sp|P0DTC2|SPIK 518 LHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSV 597 (1273) Q Consensus 518 lhapatvcgpkkstnlvknkcvnfnfngltgtgvltesnkkflpfqqfgrdiadttdavrdpqtleilditpcsfggvsv 597 (1273) ..+|..+.|-...++++.++||++|.-|.+|+|++++++..+...+.+ .|...-.++.++..++++..|+||....++| T Consensus 426 ~gv~~p~~~~~d~~~i~l~~Cv~YnIYG~tG~GvI~~~n~~~~~gl~~-~s~sG~l~~Fk~~~~g~~Y~V~PC~~~~q~V 504 (1116) T 6IXB_B 426 TGVPQPVEGVSSFMNVTLDKCTKYNIYDVSGVGVIRVSNDTFLNGITY-TSTSGNLLGFKDVTKGTIYSITPCNPPDQLV 504 (1116) T ss_dssp EECSSSCCCSCCCCCCCCSSCEEEEETTEEEEEEEEEECCCCCSCSEE-ECSSSCEEEEECTTTSCEEEEEESSCCEEEE T ss_pred EeecccccccccceeEEeCeeeeeEecCccceEEEEeeCceeeCcEEE-EeCCCCEEEEEcCCCCcEEEEeeCCCCCeEE Confidence 345555788888999999999999999999999999999999877777 7888888999999999999999999999999 Q sp|P0DTC2|SPIK 598 ITPGTNTSNQVAVLYQDVNCTEVPV-AIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEHVNNSYECDIP----IGAGICA 672 (1273) Q Consensus 598 itpgtntsnqvavlyqdvnctevpv-aihadqltptwrvystgsnvfqtragcligaehvnnsyecdip----igagica 672 (1273) +..| +...+.++.... .+... .+ .+|.+ +++. +| ...|.-| .|.|||+ T Consensus 505 V~~~---~~vgalts~n~~-~~~~~~~~----~~~~~---------~~~~----~~------~~n~~~~~~~~~~~giC~ 557 (1116) T 6IXB_B 505 VYQQ---AVVGAMLSENFT-SYGFSNVV----ELPKF---------FYAS----NG------TYNCTDAVLTYSSFGVCA 557 (1116) T ss_dssp ECSS---SEEEEECSSCCC-CSSSSCCC----CCSSS---------CCBC----CS------CCCCCCEEEEETTEEEET T ss_pred EeCC---ceEEEEEccccc-cccccceE----Eecee---------eecc----CC------ccccccceeeeceeeEee Confidence 9988 345566676655 22211 11 12322 1211 23 3333334 4899999 Q sp|P0DTC2|SPIK 673 SYQTQTNSPRRARSVASQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNL 752 (1273) Q Consensus 673 syqtqtnsprrarsvasqsiiaytmslgaensvaysnnsiaiptnftisvtteilpvsmtktsvdctmyicgdstecsnl 752 (1273) .+....-.|| .+...++ +.-....|.||+|||++|++|-+..+|.|.+|||.+|+||++.+|.+| T Consensus 558 ~g~~~~~~~~---~~~~~~~------------~~~~t~~v~IP~nft~~v~~Eyiq~~~~kv~idC~~YVC~~~~~C~~l 622 (1116) T 6IXB_B 558 DGSIIAVQPR---NVSYDSV------------SAIVTANLSIPSNWTTSVQVEYLQITSTPIVVDCSTYVCNGNVRCVEL 622 (1116) T ss_dssp TSCEECCCCC---BCCCCCC------------CCSCCEEEEEECCCCCCCEEEEEECCCCCEEECHCCCCCSSCHHHHHH T ss_pred CCCeeeecce---eccCCCC------------ccccceeEEccCCeeeeeEEEEeeccCCCeEEechhhccCCCHHHHHH Confidence 8876533332 2211111 111122599999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 753 LLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQILPDPSK----PSKRSFIEDLLFNKVTL 828 (1273) Q Consensus 753 llqygsfctqlnraltgiaveqdkntqevfaqvkqiyktppikdfggfnfsqilpdpsk----pskrsfiedllfnkvtl 828 (1273) |.|||+||..+++||.+.+..+|....+++...++-++.+.+..|++||||.+||.+.. ++.||+||||||+||.. T Consensus 623 l~qYgs~C~~I~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~n~s~~l~~~~~~~~~~~~RS~iEDlLF~KV~t 702 (1116) T 6IXB_B 623 LKQYTSACKTIEDALRNSAMLESADVSEMLTFDKKAFTLANVSSFGDYNLSSVIPSLPRSGSRVAGRSAIEDILFSKLVT 702 (1116) T ss_dssp HHHTHHHHHHHHHHHHHHHHHHHHHHHHHCCBCHHHHHTTCGGGGGGGCCTTTSCCCCSSCCC----CHHHHHHHHTCCC T ss_pred HHHhhhHHHHHHHHHHHHHhhhcHHHHHHHhcCccccccccccccCCccccccccCCCCCCCccccccHHHHHHccceee Confidence 99999999999999999999999999999999999999999999999999999998753 35799999999999999 Q sp|P0DTC2|SPIK 829 ADAGFIKQ-YGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAMQMAYRFN 907 (1273) Q Consensus 829 adagfikq-ygdclgdiaardlicaqkfngltvlpplltdemiaqytsallagtitsgwtfgagaalqipfamqmayrfn 907 (1273) +|.|++++ |.+|.+....|||+|||.+||+.||||.+++||++.||++|++|....|||. |..||||+||.+|+| T Consensus 703 ~glg~vd~dY~~C~~g~~i~DL~CaQ~ynGi~VLP~v~~~~~~a~YT~sl~g~m~~gg~t~----aaaiPFa~~vq~RlN 778 (1116) T 6IXB_B 703 SGLGTVDADYKKCTKGLSIADLACAQYYNGIMVLPGVADAERMAMYTGSLIGGIALGGLTS----AASIPFSLAIQSRLN 778 (1116) T ss_dssp ------CCCGGGTSSSSSCCCHHHHHHHTTEEECCCTTCHHHHHHHHHHHHHHHSCCSCSS----SSCCCGGGHHHHHHH T ss_pred cCCCcccHHHHHhcCCccHHHHhcccccCeEEEeCCCCCHHHHHHHHHHHHHHHHhhchhH----hhhChHHHHHHHHhh Confidence 99999988 9999999999999999999999999999999999999999999999999997 556899999999999 Q sp|P0DTC2|SPIK 908 GIGVTQNVLYENQKLIANQFNSAIGKIQDS--------------LSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAI 973 (1273) Q Consensus 908 gigvtqnvlyenqklianqfnsaigkiqds--------------lsstasalgklqdvvnqnaqalntlvkqlssnfgai 973 (1273) |+|+||+||.||||+||+.||.|||.||+. ++++|+||.|+|||||++++||++|++||+.||||| T Consensus 779 ~~~l~~~vL~~NQ~~iA~sFN~A~~~i~~~f~~~n~ai~qts~~~~t~~~Al~kiQ~VVN~~~~aL~~l~~qL~~nFgAI 858 (1116) T 6IXB_B 779 YVALQTDVLQENQKILAASFNKAMTNIVDAFTGVNDAITQTSQALQTVATALNKIQDVVNQQGNSLNHLTSQLRQNFQAI 858 (1116) T ss_dssp HHSCCCCSCCHHHHHHHHHHHHHHHHHHHHHC---------CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHSCSSSS T ss_pred hhhhcHHHHHHHHHHHHHHHHHHHHHHHHHHHhhhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 999999999999999999999999999987 455669999999999999999999999999999999 Q sp|P0DTC2|SPIK 974 SSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFP 1053 (1273) Q Consensus 974 ssvlndilsrldkveaevqidrlitgrlqslqtyvtqqliraaeirasanlaatkmsecvlgqskrvdfcgkgyhlmsfp 1053 (1273) ||.++||.+|||++||++|+||||+|||.+|.+||+|+|.|++|+|+|+.||..|+.|||..||+|.+|||.|.|++|+| T Consensus 859 Sssi~dIy~rLd~leAdaQvDRLItGRL~aLna~vtq~l~~~~~v~~sr~lA~qKinECVksQS~R~gFCGnG~Hv~S~~ 938 (1116) T 6IXB_B 859 SSSIQAIYDRLDIIQADQQVDRLITGRLAALNVFVSHTLTKYTEVRASRQLAQQKVNECVKSQSKRYGFCGNGTHIFSLV 938 (1116) T ss_dssp CSCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCTSCCSCTTTSSSSEEEEEEE T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHhhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhcCcCcCCCCCCeeEEEee Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 1054 QSAPHGVVFLHVTYVPAQEKNFTTAPAICHDG-KAHFPREGV--FVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVI 1130 (1273) Q Consensus 1054 qsaphgvvflhvtyvpaqeknfttapaichdg-kahfpregv--fvsngthwfvtqrnfyepqiittdntfvsgncdvvi 1130 (1273) |.||.|++|+|.+|+|.+-++.+++|.+|+++ ++..||++. |+.++.+|++|.|++|||..||..|...-..|||.. T Consensus 939 q~AP~Gi~F~H~~~~P~~~~~v~a~~GlC~~~~~~~~~~~~~~~~~~~~~~~~~T~r~~y~Pr~~t~~d~v~~~~c~v~y 1018 (1116) T 6IXB_B 939 NAAPEGLVFLHTVLLPTQYKDVEAWSGLCVDGRNGYVLRQPNLALYKEGNYYRITSRIMFEPRIPTIADFVQIENCNVTF 1018 (1116) T ss_dssp EEETTEEEEEEEEECCSSEEEEEECSCCCCSSSCCCCCSSTTBCCBCSSSSCBCCBSSCCCCCCCCGGGCCCCCCCCTTS T ss_pred ecCCCeEEEEEEeeccceeEEEEEEEEEeecCCceEEecCCceEeEeeCCEEEEeccccccCCCCCccceEEeecCceeE Confidence 99999999999999999999999999999995 789999887 888888999999999999999999999999999999 Q sp|P0DTC2|SPIK 1131 GIVNNTVYDPLQPELDSFKEELDKY-FKN--HTSPDVDLGDISGINASVVNIQKEIDR--------------LNEVAKNL 1193 (1273) Q Consensus 1131 givnntvydplqpeldsfkeeldky-fkn--htspdvdlgdisginasvvniqkeidr--------------lnevaknl 1193 (1273) .-++.++..+..|+.-.|++||+|+ +|+ |+-||.+ +..+|+.+.|+..||++ |+|+.|+| T Consensus 1019 ~~~~~~~~~~~~~~~~d~~~~~~~~~~~~~~~~~p~~~---~~~~n~t~lnl~~ei~~L~~~~~~l~~~~~~l~~~i~~l 1095 (1116) T 6IXB_B 1019 VNISRSELQTIVPEYIDVNKTLQELSYKLPNYTVPDLV---VEQYNQTILNLTSEISTLENKSAELNYTVQKLQTLIDNI 1095 (1116) T ss_dssp CCCCTTTHHHHSCCC----------------------------------------------------------------- T ss_pred EEcchhhcCCCCCCCCChHHHHHHHHhhCCCCCCCCCc---HHhccceeechHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 9999999999999999999999999 664 4556554 77899999999999999 99999999 Q sp|P0DTC2|SPIK 1194 NESLIDLQELGKYEQYIKWPW 1214 (1273) Q Consensus 1194 neslidlqelgkyeqyikwpw 1214 (1273) |+++|||++|++||+|||||| T Consensus 1096 N~s~idLe~L~~~e~YiKWPW 1116 (1116) T 6IXB_B 1096 NSTLVDLKWLNRVETYIKWPW 1116 (1116) T ss_dssp --------------------- T ss_pred HhcCccHHHhCeEEEEecCCC Confidence 999999999999999999999 No 15 >6CV0_A Spike protein; infectious bronchitis coronavirus, spike, pre-fusion; HET: NAG;{Infectious bronchitis virus} Probab=100.00 E-value=2.9e-125 Score=1068.92 Aligned_cols=651 Identities=31% Similarity=0.547 Sum_probs=514.4 Template_Neff=4.200 Q sp|P0DTC2|SPIK 524 VCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNK------KFLPFQQFGRDIADTTDAV--RDPQTLEILDITPCSFGGV 595 (1273) Q Consensus 524 vcgpkkstnlvknkcvnfnfngltgtgvltesnk------kflpfqqfgrdiadttdav--rdpqtleilditpcsfggv 595 (1273) +.|....++++.++||++|.-|.+|+|++++.+. -....+.+-.|.....|.. ++..++++..|+||....+ T Consensus 399 v~g~~d~snI~ld~CvdYNIYG~tG~GvItnvt~s~~~~~yl~~~Gl~ildtSg~idlf~~Kn~~~g~~Y~V~PC~~V~~ 478 (1105) T 6CV0_A 399 VITRHNYNNITLNTCVDYNIYGRTGQGFITNVTDSAVSYNYLADAGLAILDTSGSIDIFVVQGEYGLTYYKVNPCEDVNQ 478 (1105) T ss_dssp SCCSCCSCCCCCSSCEEEEETTEEEEEEEEECTTTTTTTTCSCSSCCCEECGGGCEEEEEECSSSSCEEEEEEECTTSSE T ss_pred cccccccceeEeCeeeeEEecCceeeEEEEecCCccccceeeccCCeEEEeCCCCceEEEEEcCCCCcEEEEEeCccCce Confidence 6777888999999999999999999999999655 3334444444444445544 4478999999999999999 Q sp|P0DTC2|SPIK 596 SVITPGTNTSNQVAVL-YQDVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEHVNN--SYECDIPIGAGICA 672 (1273) Q Consensus 596 svitpgtntsnqvavl-yqdvnctevpvaihadqltptwrvystgsnvfqtragcligaehvnn--syecdipigagica 672 (1273) +++..|. +-|++| +....|.++..-.. .+++-.|| +++...+. ..+|+++.|.++|. T Consensus 479 Q~VV~~~---~iVG~LTs~n~t~s~~~~n~~----------------~i~~~~g~-~~~~~s~~~~~~~c~~~~y~~~ci 538 (1105) T 6CV0_A 479 QFVVSGG---KLVGILTSRNETGSQLLENQF----------------YIKITNGT-RRFRRSITENVANCPYVSYGKFCI 538 (1105) T ss_dssp EEEEETT---EEEEEEESSCSSCSEECSSSE----------------ECCCCCSS-SCCCCCCCCCBSCCCSCBCSSEEE T ss_pred eEEEECC---EEEEEEEEeCCCcccceeceE----------------EEEeeCCc-ceeeecccCccccCcceeecceEE Confidence 9998887 788888 88888877543111 26777888 77665543 68899999999998 Q sp|P0DTC2|SPIK 673 SYQTQTNSPRRARSVASQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNL 752 (1273) Q Consensus 673 syqtqtnsprrarsvasqsiiaytmslgaensvaysnnsiaiptnftisvtteilpvsmtktsvdctmyicgdstecsnl 752 (1273) -+... ++. +..+.+..|.+- +.-+...|.||+|||++|++|-+..+|.|.+|||.+|+||++.+|.+| T Consensus 539 ~~~g~----~~~--~~~~~l~~~~~p------~~~~~~~v~IP~nFtl~v~~EyiQt~~~kV~IDC~~YVC~~~~~C~~l 606 (1105) T 6CV0_A 539 KPDGS----IAT--IVPKQLEQFVAP------LLNVTENVLIPNSFNLTVTDEYIQTRMDKVQINCLQYVCGNSLDCRDL 606 (1105) T ss_dssp CSSSC----EEE--BCCCCCCCCCCC------CCCSSCCEEEESSCCCCEEEEEEECCCCEEEECHHHHHSCSCSSSHHH T ss_pred cCCCC----eee--eccceeeecccc------cceeeeEEEccCceeEeEEEEEEeecCCceEEEchhhccCCCHHHHHH Confidence 77651 111 111222223222 122566799999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 753 LLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQI-YKTPPIKDF--GGFNFSQILPDPSKPSKRSFIEDLLFNKVTLA 829 (1273) Q Consensus 753 llqygsfctqlnraltgiaveqdkntqevfaqvkqi-yktppikdf--ggfnfsqilpdpskpskrsfiedllfnkvtla 829 (1273) |.|||+||..+++||.+.+..+|.+..+++...|.- +++|-+..| |+||||.+||.|++|++||+||||||+||..+ T Consensus 607 l~qYgs~C~~I~~al~~~~~~e~~~~~~~~~~~~~~~~~~~~~~~~~~~~fN~s~ll~~~~~~~~RS~IEDLLF~KV~t~ 686 (1105) T 6CV0_A 607 FQQYGPVCDNILSVVNSIGQKEDMELLNFYSSTKPAGFNTPFLSNVSTGEFNISLLLTTPSSPRRRSFIEDLLFTSVESV 686 (1105) T ss_dssp HTTCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCSCCCCCCCSCSCCSSCCCTTTSCCSSCSSSCCSHHHHHHTTC--- T ss_pred HHHHHHHHHHHHHHHHHHHhHHhHHHHHHHHhcCCCccccccccccCCCCcceeeecCCCCCcCcccHHHHHhcCceeec Confidence 999999999999999999999999999999999766 677777645 78999999999999999999999999999999 Q sp|P0DTC2|SPIK 830 DAGFIKQYGDCLGDI--AARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAMQMAYRFN 907 (1273) Q Consensus 830 dagfikqygdclgdi--aardlicaqkfngltvlpplltdemiaqytsallagtitsgwtfgagaalqipfamqmayrfn 907 (1273) |.|+-+.|..|.+.. .+|||+|||.+||+.||||++++||++.||++|++|....|||. |..|||||||.+|+| T Consensus 687 glg~d~~Y~~Ct~g~~~~i~DL~CAQyyNGimVLP~v~d~~~~amYTasL~g~m~~gg~ta----a~aiPFa~~vq~RlN 762 (1105) T 6CV0_A 687 GLPTDDAYKNCTAGPLGFLKDLACAREYNGLLVLPPIITAEMQTLYTSSLVASMAFGGITA----AGAIPFATQLQARIN 762 (1105) T ss_dssp ------CCCCTTSCCCCSSGGGHHHHHTTTEEEECCSSCTTSSTTHHHHHHHHHHHSSSCS----CSSCSSHHHHHHHHT T ss_pred CCCCcHHHHhccCCCCccHHHHhchhhcCcEEeeCCCCCHHHHHHHHHHHHHHHHhcchhH----hhhCcHHHHHHHHhc Confidence 999999999999996 79999999999999999999999999999999999999999994 667999999999999 Q sp|P0DTC2|SPIK 908 GIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKV 987 (1273) Q Consensus 908 gigvtqnvlyenqklianqfnsaigkiqdslsstasalgklqdvvnqnaqalntlvkqlssnfgaissvlndilsrldkv 987 (1273) ++|+||+||.||||+||+.||.|||.||+.+.++++||.|+|||||++++||++|++||+.|||||||.++||.+|||++ T Consensus 763 ~v~l~~~vL~~NQk~iA~sFN~A~~~i~~~f~~~~~Al~kiQ~VVN~q~~aL~~l~~qL~~nFgAISssi~dIy~rLd~l 842 (1105) T 6CV0_A 763 HLGITQSLLLKNQEKIAASFNKAIGRMQEGFRSTSLALQQIQHVVNKQNAILTETMASLNKNFGAISSLIQEIYQQLDAI 842 (1105) T ss_dssp TTTTCSCCCSSSSHHHHHHHHHHHHHHHHHTTSSCSHHHHHHHHHHHHHHHHTTTTTTSSSCCSSSCSCSTTTTTTSCHH T ss_pred hhhccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhHHHHHHHHHHHHHHHHH Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 988 EAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTY 1067 (1273) Q Consensus 988 eaevqidrlitgrlqslqtyvtqqliraaeirasanlaatkmsecvlgqskrvdfcgkgyhlmsfpqsaphgvvflhvty 1067 (1273) ||++|+||||||||.+|++||+|.+.+.+|.||++.||..|+.|||..||+|.+|||.|.|++|+||.||+|++|+|.+| T Consensus 843 eAdaQvDRLItGRL~aLna~vt~~~~~~~~v~~sr~LA~qKiNECVksQS~R~gFCGnG~Hv~S~~q~AP~Gi~F~H~~~ 922 (1105) T 6CV0_A 843 QANAQVDRLITGRLSSLSVLASAKQAEHIRVSQQRELATQKINECVKSQSIRYSFCGNGRHVLTIPQNAPNGIVFIHFSY 922 (1105) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCTTCCCCTTSSSSSSCCCEEEEECSSEEEEEEECC T ss_pred HHHHHhHHHHHhhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhccCcccCCCCCCeEEEeeeeccCCeEEEEEEEe Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 1068 VPAQEKNFTTAPAICHDG-----KAHFPR--EGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDP 1140 (1273) Q Consensus 1068 vpaqeknfttapaichdg-----kahfpr--egvfvsngthwfvtqrnfyepqiittdntfvsgncdvvigivnntvydp 1140 (1273) +|.+-++.+++|.+|.++ .+..|+ .|+|+.+...|++|.|++|||..||.+|...-..|||...-+|+++..| T Consensus 923 ~P~~~~~v~a~~G~C~~~~~~~~~~~~~~~~~g~~~~~n~~~~~T~r~~y~Pr~~t~~d~v~i~sC~v~y~~~~~~~l~~ 1002 (1105) T 6CV0_A 923 TPDSFVNVTAIVGFCVKPANASQYAIVPANGRGIFIQVNGSYYITARDMYMPRAITAGDIVTLTSCQANYVSVNKTVITT 1002 (1105) T ss_dssp CCCCEEEECBCCCBCCCCSSSCCCEECCCTTSCCEEEETTEEEECCSSSCCCBCCCTTSCCEESCCCSSSCCCSSCCCCC T ss_pred ccCceeEEEEEEEEEecCcccccEEEEecCCCcEEEEECCEEEEeccccccCCCCCcccEEEeecCcceEEeCCcccccC Confidence 999999999999999997 588888 8999999899999999999999999999999999999999999999998 Q sp|P0DTC2|SPIK 1141 -LQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELG-KYEQYIKW 1212 (1273) Q Consensus 1141 -lqpeldsfkeeldkyfknhtspdvdlgdisginasvvniqkeidrlnevaknlneslidlqelg-kyeqyikw 1212 (1273) ..|+.-.|+|||+|+|+++++.-.|+. +-.+|.++.|++.||++|+|+.|+||+| +||+||. |.|.|..- T Consensus 1003 ~~~pd~~Dfn~el~~~~~~~~~~~p~~~-~~n~n~t~LnLt~Ei~~l~~~i~~lN~s-~dLe~L~~~~~~~~~~ 1074 (1105) T 6CV0_A 1003 FVDNDDFDFNDELSKWWNDTKHELPDFD-KFNYTVPILDIDSEIDRIQGVIQGLNDS-VDIKQIEDKIEEILSK 1074 (1105) T ss_dssp CC------------------------------------------------------------------------ T ss_pred CCCcCCCChHHHHHHHHhcCCCCCCCcc-ccccccceechHHHHHHHHHHHHHHHhc-CCHHHHHHHHHHHHHH Confidence 579999999999999999976445563 3478889999999999999999999999 6999998 77877654 No 16 >6VV5_C Spike glycoprotein; glycoprotein, surface, receptor-binding, membrane fusion; HET: MAN, PAM, BMA, NAG;{Porcine epidemic diarrhea virus} Probab=100.00 E-value=1.7e-124 Score=1078.65 Aligned_cols=641 Identities=32% Similarity=0.536 Sum_probs=513.8 Template_Neff=4.600 Q sp|P0DTC2|SPIK 521 PATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVITP 600 (1273) Q Consensus 521 patvcgpkkstnlvknkcvnfnfngltgtgvltesnkkflpfqqfgrdiadttdavrdpqtleilditpcsfggvsvitp 600 (1273) |..+.|-....+++.++||++|.-|.+|+|++++++..++..+. -.+.+.-.++.|+..++++..|+||....++|+.. T Consensus 614 ~~pv~g~~d~s~i~l~~Cv~YnIYG~tG~GvI~~t~~~~~~g~~-y~s~~G~l~~Fk~~~~~~~Y~V~PC~~~~Q~vV~~ 692 (1356) T 6VV5_C 614 PKPFEGVTDVSFMTLDVCTKYTIYGFKGEGIITLTNSSFLAGVY-YTSDSGQLLAFKNVTSGAVYSVTPCSFSEQAAYVD 692 (1356) T ss_dssp SSCCSSCSCCCBCCCSSEEEEEETTEEEEEEEEECSCCCSSCSE-EECTTSCEEEEECTTTCCEEEEECSSCEEEEEEET T ss_pred cCCcccccccceeeeCeeeeeEeCCceeeEEEEEcCceecCceE-EEcCCCCEEEEEcCCCCCEEEEEecccCceEEEEC Confidence 44466777788999999999999999999999999988876666 57777788899999999999999999999999987 Q sp|P0DTC2|SPIK 601 GTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEHVNNSYECDIPI----GAGICASYQT 676 (1273) Q Consensus 601 gtntsnqvavlyqdvnctevpvaihadqltptwrvystgsnvfqtragcligaehvnnsyecdipi----gagicasyqt 676 (1273) |+ -|+++-. .|++. -+-+++-.|| +.|.+...+|+.|+ |.|||+.+.. T Consensus 693 g~----~Vg~lts-~n~~~--------------------~~~~~~~~~~---~~~~~~~~~c~~p~ltYg~~~ic~~g~~ 744 (1356) T 6VV5_C 693 DD----IVGVISS-LSSST--------------------FNSTRELPGF---FYHSNDGSNCTEPVLVYSNIGVCKSGSI 744 (1356) T ss_dssp TE----EEEEEES-CSCCS--------------------SSEEEEETTE---EEEESCCSCCSSEEEEETTEEEETTCCE T ss_pred CE----EEEEEEe-ecCCC--------------------CCceeecCce---eEecCCCccccceeEEeccceeecCCce Confidence 76 4555332 23321 1224555577 56667789999999 9999998776 Q sp|P0DTC2|SPIK 677 QTNSPRRARSVASQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQY 756 (1273) Q Consensus 677 qtnsprrarsvasqsiiaytmslgaensvaysnnsiaiptnftisvtteilpvsmtktsvdctmyicgdstecsnlllqy 756 (1273) -...+ +.. .... +.-....|.||+|||++|++|-+..+|.|.+|||.+|+||++.+|.+||.|| T Consensus 745 ~~~~~-~~~-------------~~~~--~~~~~~~v~IP~nft~~v~~Eyiq~~~~kv~idC~~YVC~~~~~C~~ll~qY 808 (1356) T 6VV5_C 745 GYVPS-QSG-------------QVKI--APTVTGNISIPTNFSMSIRTEYLQLYNTPVSVDCATYVCNGNSRCKQLLTQY 808 (1356) T ss_dssp EECCC-CCC-------------CCCC--CCCSSEEEEEEESCEEEEEEEEEECCCCCEEECHHHHHSSSCHHHHHHHGGG T ss_pred eeecC-ccC-------------CCCC--CcccceEEEecCCeEEEEEEEEEeecCCCeEEechhhccCCCHHHHHHHHHh Confidence 43222 110 0000 1122237899999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 757 GSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDF--GGFNFSQILPDPS-------KPSKRSFIEDLLFNKVT 827 (1273) Q Consensus 757 gsfctqlnraltgiaveqdkntqevfaqvkqiyktppikdf--ggfnfsqilpdps-------kpskrsfiedllfnkvt 827 (1273) |+||..+++||.+.+..+|-.......-..+.++.+-+..| |+|||+.+||.+. ++++||+||||||+||. T Consensus 809 gs~C~~I~~al~~~~~~e~~e~~~~~~~~~~~~~~~~~s~~~~~~~n~s~~l~~~~~~~~~~~~~~~RS~IEDLLF~KV~ 888 (1356) T 6VV5_C 809 TAACKTIESALQLSARLESVEVNSMLTISDEALQLATISSFNGDGYNFTNVLGVSVYDPASGRVVQKRSFIEDLLFNKVV 888 (1356) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHTTCSTTTSCCSSCCCTTTSCEEC--------CEECCHHHHHHHHHHC T ss_pred HHHHHHHHHHHHHHHhhhcHHHHHhHhhCHHHHhhceeecccCCCcceeeecccccCCCCCCCccCCcCHHHHHhccceE Confidence 99999999999999999855444444444556666666666 7899999999874 33789999999999999 Q sp|P0DTC2|SPIK 828 LADAGFI-KQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAMQMAYRF 906 (1273) Q Consensus 828 ladagfi-kqygdclgdiaardlicaqkfngltvlpplltdemiaqytsallagtitsgwtfgagaalqipfamqmayrf 906 (1273) .+|.|++ +.|.+|.+...+|||+|||.+||+.||||++++||++.||++|++|....|||. |..||||+||.+|+ T Consensus 889 t~glg~vD~~Y~~C~~g~~i~DL~CaQ~yNGi~VLP~v~~~~~~a~YT~sl~g~m~~gg~t~----aaaiPFa~~vq~Rl 964 (1356) T 6VV5_C 889 TNGLGTVDEDYKRCSNGRSVADLVCAQYYSGVMVLPGVVDAEKLHMYSASLIGGMVLGGFTS----AAALPFSYAVQARL 964 (1356) T ss_dssp -------CCCCTTTTSCSSCCCHHHHHHHTTEEECCCSSCHHHHHHHHHHHHHGGGCCSSSC----SSCCCHHHHHHHHH T ss_pred ecCCCCcchhHHHhcCCccHHHHhcccccCcEEEeCCCCCHHHHHHHHHHHHHHHHhcchhh----hhhChHHHHHHHHh Confidence 9999999 999999999999999999999999999999999999999999999999999997 44799999999999 Q sp|P0DTC2|SPIK 907 NGIGVTQNVLYENQKLIANQFNSAIGKIQDSL--------------SSTASALGKLQDVVNQNAQALNTLVKQLSSNFGA 972 (1273) Q Consensus 907 ngigvtqnvlyenqklianqfnsaigkiqdsl--------------sstasalgklqdvvnqnaqalntlvkqlssnfga 972 (1273) |++|+||+||.||||+||+.||.|||.||+.+ +++++||.|+|||||++++||++|++||+.|||| T Consensus 965 N~~~lt~~vL~~NQk~iA~sFN~A~~~i~~~f~~v~~ai~qts~~~~t~~~Al~kiQ~VVN~q~~aL~~l~~qL~~nFgA 1044 (1356) T 6VV5_C 965 NYLALQTDVLQRNQQLLAESFNSAIGNITSAFESVKEAISQTSKGLNTVAHALTKVQEVVNSQGAALTQLTVQLQHNFQA 1044 (1356) T ss_dssp HHHSCCCCCSSHHHHHHHHHHHHHHHHHHHHTTTGGGSCCTTTTSTTSHHHHHHHHHHHHHTTTTTHHHHHHGGGCCCSS T ss_pred hhhHhchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 99999999999999999999999999999886 8899999999999999999999999999999999 Q sp|P0DTC2|SPIK 973 ISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCG-KGYHLMS 1051 (1273) Q Consensus 973 issvlndilsrldkveaevqidrlitgrlqslqtyvtqqliraaeirasanlaatkmsecvlgqskrvdfcg-kgyhlms 1051 (1273) |||.++||.+|||++||++|+||||+|||.+|.+||+|+|.|++|+|+|+.||..|+.|||..||+|.+||| .|.|++| T Consensus 1045 ISssi~dIy~rLd~leAdaQvDRLItGRL~aLna~vsq~l~~~~~v~~sr~LA~qKinECVksQS~R~gFCGnnG~Hi~S 1124 (1356) T 6VV5_C 1045 ISSSIDDIYSRLDILSADAQVDRLITGRLSALNAFVAQTLTKYTEVQASRKLAQQKVNECVKSQSQRYGFCGGDGEHIFS 1124 (1356) T ss_dssp SCSCHHHHHTTSCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCSSCCCSTTTSSSSSEEEEE T ss_pred HHHHHHHHHHHHHHHHHhhHHHHHHHhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhcCccccCCCCCceEEEE Confidence 999999999999999999999999999999999999999999999999999999999999999999999999 7999999 Q sp|P0DTC2|SPIK 1052 FPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDG-KAHFPREGVFVS--N----G--THWFVTQRNFYEPQIITTDNTFV 1122 (1273) Q Consensus 1052 fpqsaphgvvflhvtyvpaqeknfttapaichdg-kahfpregvfvs--n----g--thwfvtqrnfyepqiittdntfv 1122 (1273) +||.||.|++|+|.+|+|.+-++.+++|.+|.++ ++..||++.|+- + + ..|++|.|++|||..||..+... T Consensus 1125 ~~q~APnGi~F~H~~~~P~~~~~v~a~~G~C~~~~~~~~~~~~~~~~~~~~~~n~~~~~~~~T~r~~y~Pr~~t~~d~v~ 1204 (1356) T 6VV5_C 1125 LVQAAPQGLLFLHTVLVPSDFVDVIAIAGLCVNDEIALTLREPGLVLFTHELQNHTATEYFVSSRRMFEPRKPTVSDFVQ 1204 (1356) T ss_dssp EEEEETTEEEEEEEEEECSEEEEEEECCCEEETTTEEEEESCTTEEEESCC-------CCEEEETTSCCCBCCCGGGEEE T ss_pred eccccCceEEEEEEeecccceeEEEEEEEEEeCCCceEEecCCceEEEeecccCCCCCeEEEeccccccCCCCCccceEE Confidence 9999999999999999999999999999999995 789999988766 3 1 58999999999999999999999 Q sp|P0DTC2|SPIK 1123 SGNCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNHT---SPDVDLGDISGINASVVNIQKEIDRL------------- 1186 (1273) Q Consensus 1123 sgncdvvigivnntvydplqpeldsfkeeldkyfknht---spdvdlgdisginasvvniqkeidrl------------- 1186 (1273) -..|||...-++.++..+..|++..|++||+|+||+++ -||.++ ..+|+.+.|++.||++| T Consensus 1205 ~~sC~v~y~n~~~~~~~~~~p~~~df~~el~~~~~~~~~~~~p~~~~---~~~n~t~Lnl~~ei~~l~~~~~~l~~~~~~ 1281 (1356) T 6VV5_C 1205 IESCVVTYVNLTRDQLPDVIPDYIDVNKTLDEILASLPNRTGPSLPL---DVFNATYLNLTGEIADLEQRSESLRNTTEE 1281 (1356) T ss_dssp ESCCCTTSEEECTTTGGGTSTTCCCHHHHHHC------------------------------------------------ T ss_pred eecCeeEEEEcccccCCCCCCCCCChHHHHHHHHHcCCCCCCCCCCh---hcceeeeechHHHHHHHHHHHHHHhchHHH Confidence 99999999999999999999999999999999999884 455544 47999999999999997 Q sp|P0DTC2|SPIK 1187 -NEVAKNLNESLIDLQELGKYEQYIKWP 1213 (1273) Q Consensus 1187 -nevaknlneslidlqelgkyeqyikwp 1213 (1273) +|+.|+||+++|||++|++||.+-+|+ T Consensus 1282 l~~~i~~lN~s~idLe~Ln~~etla~~~ 1309 (1356) T 6VV5_C 1282 LQSLIYNINNTLVDLEWLNRVETGSGYI 1309 (1356) T ss_dssp ---------------------------- T ss_pred HHHHHHHHHHhccCHHHHcceeecccCC Confidence 899999999999999999999987765 No 17 >6M3W_B Spike glycoprotein,Spike glycoprotein; spike, post-fusion, SARS-CoV, coronavirus, glycoprotein; HET: NAG;{Human SARS coronavirus} Probab=100.00 E-value=1.8e-124 Score=1000.40 Aligned_cols=491 Identities=90% Similarity=1.349 Sum_probs=338.6 Template_Neff=3.600 Q sp|P0DTC2|SPIK 706 AYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQV 785 (1273) Q Consensus 706 aysnnsiaiptnftisvtteilpvsmtktsvdctmyicgdstecsnlllqygsfctqlnraltgiaveqdkntqevfaqv 785 (1273) |++...|.||+|||++|++|-+.++|.|.+|||.+|+||++.+|.+||.|||+||..+++||.+.+..+|....+++... T Consensus 1 ~~~~~~i~IP~nFtl~v~~EyiQ~~~~kV~IDC~~YVC~~~~rC~~LL~QYgs~C~~I~~aL~~~~~led~~~~~~~s~~ 80 (491) T 6M3W_B 1 AYSNNTIAIPTNFSISITTEVMPVSMAKTSVDCNMYICGDSTECANLLLQYGSFCTQLNRALSGIAAEQDRNTREVFAQV 80 (491) T ss_dssp CCCCEEEEEEEEEEEEECCCEEECCCCCCCCCHHHHTCSSCHHHHHHHTTSTTHHHHHHHHHHHHC-------------- T ss_pred CCCcceeeccCCeEEEEEEeeeeecCCceEEechhhccCCCHHHHHHHHHHHHHHHHHHHHHHHHHHhHhHHHHHHHHHH Confidence 34567799999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 786 KQIYKTPPIKDFGGFNFSQILPDPSKPSKRSFIEDLLFNKVTLADAGFIKQYGDCLGDIAARDLICAQKFNGLTVLPPLL 865 (1273) Q Consensus 786 kqiyktppikdfggfnfsqilpdpskpskrsfiedllfnkvtladagfikqygdclgdiaardlicaqkfngltvlppll 865 (1273) ++-++.|-+..|+|||||.++|.++++++||+||||||+||..+|.|+.+.|..|.+....|||+|||.|||+.||||.. T Consensus 81 ~~~~~~~~~~~~~~~N~s~~lp~~~~~~~RS~IEDLLF~KV~t~glG~~~dYk~Ct~g~~i~DL~CaQyyNGimVLP~v~ 160 (491) T 6M3W_B 81 KQMYKTPTLKYFGGFNFSQILPDPLKPTKRSFIEDLLFNKVTLADAGFMKQYGECLGDINARDLICAQKFNGLTVLPPLL 160 (491) T ss_dssp -------------------------------------------------------------------------------- T ss_pred hHHhccCcccccCCccccccCCCCCCCCCcCHHHHHhcCceeecCCchhHhHHHccCCccHHHhhcccccCCEEeeCCCC Confidence 99999999999999999999999988999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 866 TDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASAL 945 (1273) Q Consensus 866 tdemiaqytsallagtitsgwtfgagaalqipfamqmayrfngigvtqnvlyenqklianqfnsaigkiqdslsstasal 945 (1273) ++||++.||++|++|....|||+|+|+|..||||+||.||+||+|+||+||.||||+|||.||.|++.||+.++.+++|| T Consensus 161 d~~~~a~YTasL~g~ma~gg~T~g~~saaaIPFa~~vq~RlN~valtt~VL~~NQk~iA~sFN~A~~~iq~g~~t~~~AL 240 (491) T 6M3W_B 161 TDDMIAAYTAALVSGTATAGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKQIANQFNKAISQIQESLTTTSTAL 240 (491) T ss_dssp -----------------------------------------------------CCHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred CHHHHHHHHHHHHHHHhccccccCcchhccchHHHHHHHHhccccccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 946 GKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLA 1025 (1273) Q Consensus 946 gklqdvvnqnaqalntlvkqlssnfgaissvlndilsrldkveaevqidrlitgrlqslqtyvtqqliraaeirasanla 1025 (1273) .|+|||||++++||++|++||+.|||||||.++||.+|||++||++|+||||+|||.+|.+||+|+|.|++|+|+|+.|| T Consensus 241 ~KiQ~VVN~q~~aL~~L~~qL~nnFgAISssI~dIy~RLD~leAdaQVDRLItGRL~aLnafVtq~l~~~~ev~~sr~LA 320 (491) T 6M3W_B 241 GKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLA 320 (491) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHhHHHHHHHHHHHHHHHHHHHHHHHHHHHhhHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 1026 ATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVT 1105 (1273) Q Consensus 1026 atkmsecvlgqskrvdfcgkgyhlmsfpqsaphgvvflhvtyvpaqeknfttapaichdgkahfpregvfvsngthwfvt 1105 (1273) ..|+.|||..||+|.+|||.|.|++|+||.||.|++|+|.+|+|.+-++.++.|.+|.++++..|++|+|+.|+..|++| T Consensus 321 ~qKiNECVKSQS~R~gFCGnGtHi~Si~q~APnGi~F~H~~~~Pt~~~~V~a~~GlC~~~~~~~~~~g~f~~~~~~~~iT 400 (491) T 6M3W_B 321 ATKMSECVLGQSKRVDFCGKGYHLMSFPQAAPHGVVFLHVTYVPSQERNFTTAPAICHEGKAYFPREGVFVFNGTSWFIT 400 (491) T ss_dssp HHHCCCCCSSCCCCBTSSSSSEEEEEEEEECSSEEEEEEEEEEEEEEEEEEEBSCCCSSSCCCEETTCCEECSSSCCEEC T ss_pred HHHHHHHHhccCcCcCcCCCCeeEEeccccCCCeEEEEEEEeCccceeEEEEeceEeecCceEeeeceeEEEcCcEEEEe Confidence 99999999999999999999999999999999999999999999999999999999999998999999999899999999 Q sp|P0DTC2|SPIK 1106 QRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDR 1185 (1273) Q Consensus 1106 qrnfyepqiittdntfvsgncdvvigivnntvydplqpeldsfkeeldkyfknhtspdvdlgdisginasvvniqkeidr 1185 (1273) .|++|||..||..|...-..|||...-+|+++.+|++|++..|+|||++|+||+|+|+.++++++.+|+++.|++.||++ T Consensus 401 ~r~my~Pr~~t~~d~V~itsC~V~y~Nvn~~~~~~~~Pdy~df~del~~~~~N~T~p~~~l~~ld~fN~T~LNLt~EI~~ 480 (491) T 6M3W_B 401 QRNFFSPQIITTDNTFVSGNCDVVIGIINNTVYDPLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDR 480 (491) T ss_dssp CSSSCCCEECCSSSEECCSSCCCBCCCCCCSCCCCCCCCCCCHHHHHHHSCCCCCCCCCCCSHHHHCCCCCCCCCHHHHH T ss_pred ccccccCccCCCCceEEeecceeEEEEecccccCCCCCCCCCHHHHHHHHccCCCCCCCCCCCcccccccccchHHHHHH Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 1186 LNEVAKNLNES 1196 (1273) Q Consensus 1186 lnevaknlnes 1196 (1273) |++++++||+| T Consensus 481 Lq~~i~~Ln~s 491 (491) T 6M3W_B 481 LNEVAKNLNES 491 (491) T ss_dssp HHHHHHHHHHC T ss_pred HHHHHHHHHcC Confidence 99999999986 No 18 >6U7K_C Spike glycoprotein; PEDV, Spike, Coronavirus, Fusion Protein; HET: MAN, BMA, NAG; 3.14A {Porcine epidemic diarrhea virus (strain CV777)} Probab=100.00 E-value=1.1e-122 Score=1065.47 Aligned_cols=641 Identities=33% Similarity=0.542 Sum_probs=505.8 Template_Neff=4.600 Q sp|P0DTC2|SPIK 521 PATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVITP 600 (1273) Q Consensus 521 patvcgpkkstnlvknkcvnfnfngltgtgvltesnkkflpfqqfgrdiadttdavrdpqtleilditpcsfggvsvitp 600 (1273) |..+.|-....|++.++||++|..|.+|+|++++++..+...+ +..+.+...++.|+..++++..|+||..+.+.|+.. T Consensus 629 ~~pv~g~~d~sni~l~~CvdYnIYG~tG~GvI~~t~~~~~~g~-~y~s~~G~l~~Fk~~~~~~~Y~V~PC~~~~Q~vv~~ 707 (1399) T 6U7K_C 629 PKPLEGITDVSFMTLDVCTKYTIYGFKGEGIITLTNSSILAGV-YYTSDSGQLLAFKNVTSGAVYSVTPCSFSEQAAYVN 707 (1399) T ss_dssp SSCCCCSSCCCBCCCSSEEEEEETTEEEEEEEEEESCCCSSCS-EEECSSSSEEEEECTTTCCEEEEECSSCEEEEEEET T ss_pred cCCCccccccceeeeCeeEeeEeCCceeeEEEEEcCceeeCce-EEEcCCCCEEEEECCCCCCEEEEEeceeccEEEEEC Confidence 4446777888999999999999999999999999998887777 889999999999999999999999999887744443 Q sp|P0DTC2|SPIK 601 GTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEHVNNSYECDIPI----GAGICASYQT 676 (1273) Q Consensus 601 gtntsnqvavlyqdvnctevpvaihadqltptwrvystgsnvfqtragcligaehvnnsyecdipi----gagicasyqt 676 (1273) |+ -|.++ ...|++. ..| +++-.|| +.|.+...+|+.|+ |.|||+.+.. T Consensus 708 ~~----~vg~l-ts~n~~~-------------------~~~-~~~~~~~---~~~s~~~~~c~~p~ltYg~~~ic~~g~~ 759 (1399) T 6U7K_C 708 DD----IVGVI-SSLSNST-------------------FNN-TRELPGF---FYHSNDGSNCTEPVLVYSNIGVCKSGSI 759 (1399) T ss_dssp TE----EEEEE-ESCSCCS-------------------SSE-EEECSSC---EEEESCCSCCSCEEEEETTEEEETTSCE T ss_pred CE----EEEEe-EeeeCCC-------------------CCC-eeecCce---eEecCCCcccccceEEecCceeeecCcc Confidence 22 23322 2223321 223 6778888 77888899999999 9999998876 Q sp|P0DTC2|SPIK 677 QTNSPRRARSVASQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQY 756 (1273) Q Consensus 677 qtnsprrarsvasqsiiaytmslgaensvaysnnsiaiptnftisvtteilpvsmtktsvdctmyicgdstecsnlllqy 756 (1273) -.-+|+ .+.. .|. . -....|.||+|||++|++|-+.++|.|.+|||.+|+||++.+|.++|.|| T Consensus 760 ~~~~~~-~~~~------~~~--~-------~~~~~v~IP~nft~~v~~Eyiq~~~~kV~VdCnvYVC~~N~rC~~lL~QY 823 (1399) T 6U7K_C 760 GYVPSQ-YGQV------KIA--P-------TVTGNISIPTNFSMSIRTEYLQLYNTPVSVDCATYVCNGNSRCKQLLTQY 823 (1399) T ss_dssp EECCCC-BCCC------CCC--C-------CSSSEEEEECSEEEEEEEEEEECCCCCEEECHHHHHHTTCHHHHHHHTTS T ss_pred ccccCc-cccc------ccc--c-------ccceeEEecCCeEEEEEEEEEeecCCCeEEEceEEEeCCCHHHHHHHHHH Confidence 433331 1111 110 0 11227899999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 757 GSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDF--GGFNFSQILPDPS----K---PSKRSFIEDLLFNKVT 827 (1273) Q Consensus 757 gsfctqlnraltgiaveqdkntqevfaqvkqiyktppikdf--ggfnfsqilpdps----k---pskrsfiedllfnkvt 827 (1273) |+||..+|.||.+.+-.++-...+....-.+.++++-+..| ++|||+.++|.+. + ++.||+||||||+||. T Consensus 824 gs~C~nIn~aL~~s~~le~~E~~~~~t~si~~l~~~~~s~~~~~d~N~s~ll~~~~~~p~~d~~~~~RSvIEDLLF~KV~ 903 (1399) T 6U7K_C 824 TAACKTIESALQLSARLESVEVNSMLTISEEALQLATISSFNGDGYNFTNVLGASVYDPASGRVVQKRSVIEDLLFNKVV 903 (1399) T ss_dssp TTHHHHHHHHHHHHHHHHHHHHHHHCCBCHHHHHHHTTSCCCCTTCCCHHHHCC------------CCCHHHHHHHHTTT T ss_pred HHHHHHHHHHHHHHHhhhhHHHHhhhccCHHHHhhhceeccCCCcceeeeeeccccCCCCCCCcCCcccHHHHHheeceE Confidence 99999999999998877644333334444555555555444 7899999887542 2 4789999999999999 Q sp|P0DTC2|SPIK 828 LADAGFI-KQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAMQMAYRF 906 (1273) Q Consensus 828 ladagfi-kqygdclgdiaardlicaqkfngltvlpplltdemiaqytsallagtitsgwtfgagaalqipfamqmayrf 906 (1273) .+|.|++ +.|..|.+...+|||+|||.+||+.||||++++||++.||++|++|....|||. |..||||+||.+|+ T Consensus 904 t~glg~vD~~Y~~C~~g~~i~DL~CaQ~yNGi~VLP~v~~~~~~a~YT~sl~g~m~~gg~ta----aaaiPFa~~vq~Rl 979 (1399) T 6U7K_C 904 TNGLGTVDEDYKRCSNGRSVADLVCAQYYSGVMVLPGVVDAEKLHMYSASLIGGMALGGITA----AAALPFSYAVQARL 979 (1399) T ss_dssp TTCCSSSCCCGGGGSSCSSCCCHHHHHHHTTEEECCCSSCHHHHHHHHHHHHGGGGCCCSSC----SSCCCHHHHHHHHH T ss_pred ecCCCCcchhhHHhcCCccHHHHhcccccCcEEEeCCCCCHHHHHhHHHHHHHHHHhcchhH----hhhChHHHHHHHHh Confidence 9999999 999999999999999999999999999999999999999999999999999997 66799999999999 Q sp|P0DTC2|SPIK 907 NGIGVTQNVLYENQKLIANQFNSAIGKIQDSLS--------------STASALGKLQDVVNQNAQALNTLVKQLSSNFGA 972 (1273) Q Consensus 907 ngigvtqnvlyenqklianqfnsaigkiqdsls--------------stasalgklqdvvnqnaqalntlvkqlssnfga 972 (1273) |++|+||+||.||||+||+.||.||+.||+.++ ++++||.|+|||||++++||++|++||+.|||| T Consensus 980 N~~~lt~~vL~~NQk~iA~sFN~A~~~iq~~f~~v~~ai~qts~~~~t~~~Al~kiQ~VVN~~~~aL~~l~~qL~~nFgA 1059 (1399) T 6U7K_C 980 NYLALQTDVLQRNQQLLAESFNSAIGNITSAFESVKEAISQTSKGLNTVAHALTKVQEVVNSQGSALNQLTVQLQHNFQA 1059 (1399) T ss_dssp HTTSCCCCCSSTHHHHHHHHHHHHHHHHHTTTTCCGGGCCGGGGSTTSHHHHHHHHHHHHHHTTHHHHHHHHTTSCCTTS T ss_pred hhhHHchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 999999999999999999999999999999866 899999999999999999999999999999999 Q sp|P0DTC2|SPIK 973 ISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCG-KGYHLMS 1051 (1273) Q Consensus 973 issvlndilsrldkveaevqidrlitgrlqslqtyvtqqliraaeirasanlaatkmsecvlgqskrvdfcg-kgyhlms 1051 (1273) |||.++||++|||++||++|+||||+|||.+|.+||+|+|+|++|+|+|+.||..|+.|||..||+|.+||| .|.|++| T Consensus 1060 ISssi~dIy~rLd~leAdaQvDRLItGRL~aLna~vtq~l~~~~~v~~sr~LA~qKinECVksQS~R~gFCGnnG~Hv~S 1139 (1399) T 6U7K_C 1060 ISSSIDDIYSRLDILSADVQVDRLITGRLSALNAFVAQTLTKYTEVQASRKLAQQKVNECVKSQSQRYGFCGGDGEHIFS 1139 (1399) T ss_dssp SCSCHHHHHTTSCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCSSCCCSTTTTTSSSEEEEE T ss_pred HHHHHHHHHHHHHHHHHhhHHHHHHhhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhcCccccCCCCCceEEEE Confidence 999999999999999999999999999999999999999999999999999999999999999999999999 7999999 Q sp|P0DTC2|SPIK 1052 FPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDG-KAHFPREGVFVSNG--------THWFVTQRNFYEPQIITTDNTFV 1122 (1273) Q Consensus 1052 fpqsaphgvvflhvtyvpaqeknfttapaichdg-kahfpregvfvsng--------thwfvtqrnfyepqiittdntfv 1122 (1273) +||.||.|++|+|.+|+|.+-++.+++|.+|+++ ++..||++.|+-.. ..|++|.|++|||..||.++... T Consensus 1140 ~~q~APnGi~F~H~~~~P~~~~~v~a~~G~C~~~~~~~~~~~~~~v~~~~~~~~~~~~~~~~T~r~~y~Pr~~t~~d~v~ 1219 (1399) T 6U7K_C 1140 LVQAAPQGLLFLHTVLVPGDFVNVLAIAGLCVNGEIALTLREPGLVLFTHELQTYTATEYFVSSRRMFEPRKPTVSDFVQ 1219 (1399) T ss_dssp EEEEETTEEEEEEEEEEESCEEEEEECCCEEETTTEEEEESCTTEEEEESCTTSSSCSCCEEEESSSCCCBCCCTTTEEE T ss_pred eccccCceEEEEEEEeccCceEEEEEEEEEEecCCeeEEecCCceEEEeeCCcccccceEEEeccccccCCCCCccceEE Confidence 9999999999999999999999999999999995 78999999766532 48999999999999999999999 Q sp|P0DTC2|SPIK 1123 SGNCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNHT---SPDVDLGDISGINASVVNIQKEIDRLNE----------- 1188 (1273) Q Consensus 1123 sgncdvvigivnntvydplqpeldsfkeeldkyfknht---spdvdlgdisginasvvniqkeidrlne----------- 1188 (1273) -..|||...-++.++..+..|++-.|++||+|+||+++ .||.++ ..+|+.+.|++.||++|++ T Consensus 1220 ~~~c~v~y~~~~~~~~~~~~p~~~d~~~~l~~~~~~~~~~~~p~~~~---~~~n~t~lnl~~ei~~l~~~~~~l~~~~~~ 1296 (1399) T 6U7K_C 1220 IESCVVTYVNLTSDQLPDVIPDYIDVNKTLDEILASLPNRTGPSLPL---DVFNATYLNLTGEIADLEQRSESLRNTTEE 1296 (1399) T ss_dssp ESSCCTTSEEECTTTHHHHSTTC--------------------------------------------------------- T ss_pred eecCeeEEEEcCcccCCCCCCCCCChHHHHHHHHHcCCCCCCCCCCh---hcceeeeechHHHHHHHHHHHHHHHhHHHH Confidence 99999999999999999999999999999999999884 455543 4789999999999999877 Q sp|P0DTC2|SPIK 1189 ---VAKNLNESLIDLQELGKYEQYIKWP 1213 (1273) Q Consensus 1189 ---vaknlneslidlqelgkyeqyikwp 1213 (1273) +.|+||+++|||++|++||.|+||- T Consensus 1297 ~~~~i~~lN~s~idLe~L~~~et~~~~~ 1324 (1399) T 6U7K_C 1297 LRSLINNINNTLVDLEWLNRVETGSGYI 1324 (1399) T ss_dssp ---------------------------- T ss_pred HHHHHHHHHHhccCHHHHcceeecCccC Confidence 9999999999999999999999993 No 19 >6BFU_C Spike protein; coronavirus spike glycoprotein, porcine deltacoronavirus; HET: MAN, BMA, NAG; 3.5A {Porcine deltacoronavirus} Probab=100.00 E-value=3.5e-119 Score=1017.49 Aligned_cols=746 Identities=30% Similarity=0.489 Sum_probs=605.1 Template_Neff=4.700 Q sp|P0DTC2|SPIK 267 VGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQ-PTESIVRFPNITNLCPFGEVFNAT 345 (1273) Q Consensus 267 vgylqprtfllkynengtitdavdcaldplsetkctlksftvekgiyqtsnfrvq-ptesivrfpnitnlcpfgevfnat 345 (1273) +.|...-..|+ |-.||+|.|.+.|--.|+..-||.-.+|....|.|..++..+. ..+.+|..|+..+....- .|.+ T Consensus 240 va~a~~tdVL~-~f~ngtIq~viyCD~sp~~~LaCqy~tfnfsDGFYp~t~~~~v~~~ktfV~lP~~~nhT~v~--ln~t 316 (1024) T 6BFU_C 240 FALANLTDTLI-TLTNTTISQITYCDKSVVDSIACQRSSHEVEDGFYSDPKSAVRARQRTIVTLPKLPELEVVQ--LNIS 316 (1024) T ss_dssp EEEEEEEEEEE-EEETTEEEEEEETTTCHHHHHHHHTTSSSCCSEEEECGGGCBCCSEEEEECSCCCCCEEEEE--EEEE T ss_pred EEEeeccchhe-eeeCCcccEEEECCCChhcccchhccccccCCCccCCCccccccCCceEEEcCCCCceeEEE--EEEE Confidence 34444444555 8899999999999977999999999999999999999988764 556899999987765421 1111 Q sp|P0DTC2|SPIK 346 RFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKL 425 (1273) Q Consensus 346 rfasvyawnrkrisncvadysvlynsasfstfkcygvsptklndlcftnvyadsfvirgdevrqiapgqtgkiadynykl 425 (1273) -+...-+ ... +++..|+ -+..|..+ ++ +.+ T Consensus 317 f~n~s~a---g~v----------------~~i~~~~-----~s~yCV~n----s~----------------------ft~ 346 (1024) T 6BFU_C 317 AHMDFGE---ARL----------------DSVTING-----NTSYCVTK----PY----------------------FRL 346 (1024) T ss_dssp EEEETTE---EEE----------------EEEEETT-----BSEEECCS----SE----------------------EEE T ss_pred EeecCCC---Ccc----------------eeEEEec-----cceeEecC----Ce----------------------EEE Confidence 1110000 000 0011111 11122211 00 111 Q sp|P0DTC2|SPIK 426 PDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERD----------ISTEIYQAGSTPCNGVEGFNCYFPLQSY 495 (1273) Q Consensus 426 pddftgcviawnsnnldskvggnynylyrlfrksnlkpferd----------isteiyqagstpcngvegfncyfplqsy 495 (1273) ..+|.. |+.|.+ .+ ..--||..+ ++-.+.+.| |-++.... T Consensus 347 ~~~f~~--------------g~sy~~----~~-~~sCpFr~e~INNyL~FnSlCvSl~~gg-----------Ck~~v~~~ 396 (1024) T 6BFU_C 347 ETNFMC--------------TGCTMN----LR-TDTCSFDLSAVNNGMSFSQFCLSTESGA-----------CEMKIIVT 396 (1024) T ss_dssp EEECCE--------------ESSEEE----EE-ESSSSSCHHHHTTTCEEEEEEEESSCCS-----------EEEEEEEE T ss_pred EEEEee--------------ccCccc----cc-CCCCCCChhhccCCCccCeEEEEeCCCc-----------eeeEEEEE Confidence 111110 001111 00 011122211 111111222 54444432 Q sp|P0DTC2|SPIK 496 GFQPTNGVGYQPYRVVVLSFE---LLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADT 572 (1273) Q Consensus 496 gfqptngvgyqpyrvvvlsfe---llhapatvcgpkkstnlvknkcvnfnfngltgtgvltesnkkflpfqqfgrdiadt 572 (1273) . ...|++++.|.++++ ......++|. +..++++.++||++|.-|.+|+|+++++|..+...+.+ .|...- T Consensus 397 ~-----~~sy~~~~~VyVt~s~Gsri~g~~~~~~-~d~s~i~l~~CvdYnIYG~tG~GvI~~~n~~~~~Gl~~-~s~sG~ 469 (1024) T 6BFU_C 397 Y-----VWNYLLRQRLYVTAVEGQTHTGTTSVHA-TDTSSVITDVCTDYTIYGVSGTGIIKPSDLLLHNGIAF-TSPTGE 469 (1024) T ss_dssp S-----SSEEECSCCEEEEEEEEEEEEECSSSSC-CCTTCCCCSSEEEEEETTEEEEEEEEECSCCCCSCSEE-ECTTSC T ss_pred E-----EeeeeceeEEEEEecCCCeeeccCCccC-CCCCceeeceeeeEEecCeeeeEEEecCCEEeeCcEEE-EcCCCC Confidence 1 123678888888877 3334445664 56699999999999999999999999999999989988 899999 Q sp|P0DTC2|SPIK 573 TDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTRAGCLIG 652 (1273) Q Consensus 573 tdavrdpqtleilditpcsfggvsvitpgtntsnqvavlyqdvnctevpvaihadqltptwrvystgsnvfqtragclig 652 (1273) .++.+++.++++..|+||....++|+..|.- |+ ++...| +++++.|++..||..+ T Consensus 470 L~~Fk~~~~g~~Y~V~PC~~v~Q~vV~~g~i----VG-~lts~n--------------------~t~s~~f~~~~~~~~~ 524 (1024) T 6BFU_C 470 LYAFKNITTGKTLQVLPCETPSQLIVINNTV----VG-AITSSN--------------------STENNRFTTTIVTPTF 524 (1024) T ss_dssp EEEEEETTTTEEEEEECSSCCEEEEEETTEE----EE-EEESCG--------------------GGCCTTCSEEEEETTE T ss_pred eeEEEeCCCCCEEEEeeCCCCcEEEEECCEE----EE-EEEccC--------------------CCCCccccceeEecee Confidence 9999999999999999999877765544433 22 122222 3478889999999999 Q sp|P0DTC2|SPIK 653 AEHVNN-SYECDIPIGA----GICASYQTQTNSPRRARSVASQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEIL 727 (1273) Q Consensus 653 aehvnn-syecdipiga----gicasyqtqtnsprrarsvasqsiiaytmslgaensvaysnnsiaiptnftisvtteil 727 (1273) +.+.++ ..+|+.|+|. |||+.+..-...|+.. + ..-.+...++.|.||+|||++|++|-+ T Consensus 525 ~~~s~~~~~~C~~p~~syg~~giC~dg~~~~~~~~~~----------~-----~p~~~~~vt~~i~IP~nft~~v~~Eyi 589 (1024) T 6BFU_C 525 FYSTNATTFNCTKPVLSYGPISVCSDGAIVGTSTLQN----------T-----RPSIVSLYDGEVEIPSAFSLSVQTEYL 589 (1024) T ss_dssp EEEECCSCCCCSCEEEEETTEEEETTSCEEECCCEEC----------C-----CSCSSCCCCSSEEEEEEEEEEEEEEEE T ss_pred eeecCCCccccccceeeccceeEccCCccccceeeec----------c-----CCceeeccCeEEEccCceEeeEEEeEE Confidence 999875 7999999999 9999886633322110 0 111123344589999999999999999 Q sp|P0DTC2|SPIK 728 PVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFG-GFNFSQIL 806 (1273) Q Consensus 728 pvsmtktsvdctmyicgdstecsnlllqygsfctqlnraltgiaveqdkntqevfaqvkqiyktppikdfg-gfnfsqil 806 (1273) ..+|.|.+|||.+|+||++.+|.+||.|||+||..+++||.+.+..+|.+..+++...++-++.+-|..|+ +||||.+| T Consensus 590 q~~~~kv~idC~~YVC~~~~~C~~ll~qYg~~C~~I~~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~n~s~~l 669 (1024) T 6BFU_C 590 QVQAEQVIVDCPQYVCNGNSRCLQLLAQYTSACSNIEAALHSSAQLDSREIINMFQTSTQSLQLANITNFKGDYNFSSIL 669 (1024) T ss_dssp ECCCCEEEECHHHHHHTTBHHHHHHHTTSTTHHHHHHHHHHHHHHHHHHHHHHHTCEEHHHHHHTCGGGGCSSSCCTTTS T ss_pred eeecCceEEecchhhcCCCHHHHHHHHHhhhHHHHHHHHHHHHHhhhhHHHHHHHhhCcccccccccccCCCCccchhhc Confidence 99999999999999999999999999999999999999999999999999999999999999998888884 69999999 Q sp|P0DTC2|SPIK 807 PDPSKPSKRSFIEDLLFNKVTLADAGFI-KQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSG 885 (1273) Q Consensus 807 pdpskpskrsfiedllfnkvtladagfi-kqygdclgdiaardlicaqkfngltvlpplltdemiaqytsallagtitsg 885 (1273) |.+. +.||+||||||+||..+|.|++ +.|.+|.+....|||+|||.+||+.||||.+++||++.||++|++|....| T Consensus 670 ~~~~--~~RS~iEDlLF~KV~t~glg~vD~~Y~~C~~g~~i~DL~CaQ~ynGi~VLP~v~~~~~~a~YT~sl~g~m~~gg 747 (1024) T 6BFU_C 670 TTRI--GGRSAIEDLLFNKVVTSGLGTVDQDYKSCSRDMAIADLVCSQYYNGIMVLPGVVDAEKMAMYTGSLTGAMVFGG 747 (1024) T ss_dssp CSST--TCCCHHHHHCCCCCCC------CCCGGGGGSTTGGGSHHHHHHTTTEEEECCSSCHHHHHHHHHHHHHGGGCCS T ss_pred CCCC--CCccHHHHHHcceeeecCCCccchHHHhccCCccHHHHhhccccCeEEEeCCCCCHHHHHHHHHHHHHHHHhhc Confidence 8774 7999999999999999999999 899999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 886 WTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSS--------------TASALGKLQDV 951 (1273) Q Consensus 886 wtfgagaalqipfamqmayrfngigvtqnvlyenqklianqfnsaigkiqdslss--------------tasalgklqdv 951 (1273) ||. |..||||+||.+|+|++|+||+||.||||+|||.||.|||.||+.+++ +++||.|+||| T Consensus 748 ~ta----aaaiPFa~~vq~RlN~~~lt~~vL~~NQ~~iA~sFN~A~~~i~~~f~~v~~ai~qts~~~~t~~~Al~kiQ~V 823 (1024) T 6BFU_C 748 LTA----AAAIPFATAVQARLNYVALQTNVLQENQKILAESFNQAVGNISLALSSVNDAIQQTSEALNTVAIAIKKIQTV 823 (1024) T ss_dssp SSS----SCCCCHHHHHHHHHHHHTTSSSCCSTTHHHHHHHHHHHHHHHHHHHHTTCCSCCTTCHHHHHHHHHHHHHHHH T ss_pred HHH----hHhChHHHHHHHHhhhhhhchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 997 556899999999999999999999999999999999999999988555 99999999999 Q sp|P0DTC2|SPIK 952 VNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSE 1031 (1273) Q Consensus 952 vnqnaqalntlvkqlssnfgaissvlndilsrldkveaevqidrlitgrlqslqtyvtqqliraaeirasanlaatkmse 1031 (1273) ||++++||++|++||+.|||||||.++||.+|||++||++|+||||+|||.+|.+||+|+|.|++|+|+|+.||..|+.| T Consensus 824 VN~~~~aL~~l~~qL~~nFgAISssi~dIy~rLd~leAdaQvDRLItGRL~aLna~vtq~l~~~~~v~~sr~lA~qKinE 903 (1024) T 6BFU_C 824 VNQQGEALSHLTAQLSNNFQAISTSIQDIYNRLEEVEANQQVDRLITGRLAALNAYVTQLLNQMSQIRQSRLLAQQKINE 903 (1024) T ss_dssp HHTTTHHHHHHHHGGGCCCSSSCSCHHHHHHHSCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 1032 CVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDG-KAHFPREGVF-VSNGTHWFVTQRNF 1109 (1273) Q Consensus 1032 cvlgqskrvdfcgkgyhlmsfpqsaphgvvflhvtyvpaqeknfttapaichdg-kahfpregvf-vsngthwfvtqrnf 1109 (1273) ||..||+|.+|||.|.|++|+||.||.|++|+|.+|+|.+-++.+++|.+|+++ ++..|+.|.+ +.+...|++|.|++ T Consensus 904 CVksQS~R~gFCGnG~Hv~S~~q~AP~Gi~F~H~~~~P~~~~~v~a~~G~C~~~~~~~~~~~g~~~~~~n~~~~~T~r~~ 983 (1024) T 6BFU_C 904 CVKSQSPRYGFCGNGTHIFSLTQTAPNGIFFMHAVLVPNKFTRVNASAGICVDNTRGYSLQPQLILYQFNNSWRVTPRNM 983 (1024) T ss_dssp CCCSCCCCTTTSSSSEEEEEEEEEETTEEEEEEEEEEEEEEEEECCBCEEEETTTEEEEECTTEEEEEETTEEEEEESSS T ss_pred HHhccCCCcCCCCCCeeEEEeeecCCCeEEEEEEEecccceeEEEEEEEEeecCCceEEeCCceEEEeeCCEEEEecccc Confidence 999999999999999999999999999999999999999999999999999995 7888888866 78778999999999 Q sp|P0DTC2|SPIK 1110 YEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDSF 1148 (1273) Q Consensus 1110 yepqiittdntfvsgncdvvigivnntvydplqpeldsf 1148 (1273) |||..||..|...-..|||...-+|+++..+..|++-.| T Consensus 984 y~Pr~~t~~d~v~~~sC~v~y~n~~~~~~~~~~p~~~D~ 1022 (1024) T 6BFU_C 984 YEPRLPRQADFIQLTDCSVTFYNTTAANLPNIIPDIIDV 1022 (1024) T ss_dssp CCCBCCCGGGEEEESSCCTTSEEECTTTGGGTSTTCCCT T ss_pred ccCCCCCcccEEEcccceeEEEECCcccCCCCCCCCCCC Confidence 999999999999999999999999999999988886544 No 20 >6B3O_B Spike glycoprotein; Coronavirus, membrane fusion, MHV, SARS; 4.1A {Murine coronavirus} Probab=100.00 E-value=7.3e-117 Score=954.95 Aligned_cols=497 Identities=42% Similarity=0.726 Sum_probs=333.3 Template_Neff=3.300 Q sp|P0DTC2|SPIK 703 NSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVF 782 (1273) Q Consensus 703 nsvaysnnsiaiptnftisvtteilpvsmtktsvdctmyicgdstecsnlllqygsfctqlnraltgiaveqdkntqevf 782 (1273) .....++..|.||+|||++|++|-+.++|.|.+|||.+|+||++.+|.+||.|||+||..+++||.|.+..+|....+++ T Consensus 45 ~~~~~~~~~isIP~nFtlsv~~EyiQt~~~kVsIDC~~YVCngn~rC~~LL~QYgs~C~~I~~aL~~v~~~~d~~~~~~~ 124 (605) T 6B3O_B 45 VQSVDGLYEMQIPTNFTIGHHEEFIQTRSPKVTIDCAAFVCGDNTACRQQLVEYGSFCVNVNAILNEVNNLLDNMQLQVA 124 (605) T ss_dssp -CBCSCCCCEEEEEEEEEEEEEEEEECSCCCCCCCHHHHHTCSCHHHHHHHTTSCSHHHHHHHHHHHC------------ T ss_pred CcccCcceEEEecCceEeEEEEEEeeccCCCeEEehhhhccCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 45778888999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 783 AQVKQIYKTP-----PI-KDFGGFNFSQILPD-----------PSKPSKRSFIEDLLFNKVTLADAGFIKQYGDCLGDIA 845 (1273) Q Consensus 783 aqvkqiyktp-----pi-kdfggfnfsqilpd-----------pskpskrsfiedllfnkvtladagfikqygdclgdia 845 (1273) ...++.+..+ .| ...|+||||.++|. |++|+.||+|||||||||..+|.|+.+.|..|.+... T Consensus 125 ~~~~~~~~~s~~~~~~i~~~~g~fN~s~ll~~~~~~~~~~~~~~~~~~~RSaIEDLLFnKVvt~glGt~~dYk~Ct~g~~ 204 (605) T 6B3O_B 125 SALMQGVTISSRLPDGISGPIDDINFSPLLGCIGSTCAEDGNGPSAIRGRSAIEDLLFDKVKLSDVGFVEAYNNCTGGQE 204 (605) T ss_dssp -------------------------------------------------------------------------------- T ss_pred HHHhccCcccccCCCCCCCCCCCccchhhcccccCCcccCCCCCCcCCCccHHHHHHCCceEecCCchhHHHHhccCCcc Confidence 9998888764 22 33456999999986 7778899999999999999999999999999999999 Q sp|P0DTC2|SPIK 846 ARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIAN 925 (1273) Q Consensus 846 ardlicaqkfngltvlpplltdemiaqytsallagtitsgwtfgagaalqipfamqmayrfngigvtqnvlyenqklian 925 (1273) .|||+|||.|||+.||||..++||++.||++|.+|....|||. |..||||+||.||+||+|+||+||.||||+||| T Consensus 205 iaDL~CAQyyNGImVLPpVvda~~~amYTaSL~G~ma~gG~Ta----AaaIPFa~~vQaRlNyvaltt~VLq~NQk~iAn 280 (605) T 6B3O_B 205 VRDLLCVQSFNGIKVLPPVLSESQISGYTTGATAAAMFPPWSA----AAGVPFSLSVQYRINGLGVTMNVLSENQKMIAS 280 (605) T ss_dssp ----------------------------------------------------------------------------CHHH T ss_pred hHHHhCccccCcEEeeCCCCCHHHHHHHHHHHHHHhhcccchh----cccCchHHHHHHHhcccccchHHHHHHHHHHHH Confidence 9999999999999999999999999999999999999999997 556899999999999999999999999999999 Q sp|P0DTC2|SPIK 926 QFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQ 1005 (1273) Q Consensus 926 qfnsaigkiqdslsstasalgklqdvvnqnaqalntlvkqlssnfgaissvlndilsrldkveaevqidrlitgrlqslq 1005 (1273) .||.|+|.||+.++++++||.|+|||||++++||++|++||+.|||||||.++||.+|||++||++|+||||||||.+|. T Consensus 281 sFN~AignIq~gf~tta~AL~KIQdVVN~q~~aL~~Lt~QL~nNFgAISSSI~dIy~RLD~leAdaQVDRLItGRL~aLN 360 (605) T 6B3O_B 281 AFNNALGAIQDGFDATNSALGKIQSVVNANAEALNNLLNQLSNRFGAISASLQEILTRLEAVEAKAQIDRLINGRLTALN 360 (605) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhHHHHHHHHHHHHHHHHHHHHHHHHHHHhHHHHHH Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 1006 TYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDG 1085 (1273) Q Consensus 1006 tyvtqqliraaeirasanlaatkmsecvlgqskrvdfcgkgyhlmsfpqsaphgvvflhvtyvpaqeknfttapaichdg 1085 (1273) +||+|+|.+++|+|+|+.||..|+.|||..||+|.+|||.|.|++|+||.||.|++|+|.+|+|.+-++.++.|.+|.++ T Consensus 361 afVtQ~L~~~~eVr~sr~LA~qKINECVKSQS~RygFCGnGtHifSi~q~APnGi~FlH~~y~Pt~~~~V~A~~GlCv~~ 440 (605) T 6B3O_B 361 AYISKQLSDSTLIKVSAAQAIEKVNECVKSQTTRINFCGNGNHILSLVQNAPYGLYFIHFSYVPISFTTANVSPGLCISG 440 (605) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHTTTSSCCCCBSCSSSSEEEEEEEEEETTEEEEEEEEEEEEEEEEECCBSCEECSS T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHhcCCCccCcCCCCeEEEEeeeccCCeEEEEEEEecccceEEEEEEeeEEecC Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999995 Q sp|P0DTC2|SPIK 1086 -KAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNHTSPDV 1164 (1273) Q Consensus 1086 -kahfpregvfvsngthwfvtqrnfyepqiittdntfvsgncdvvigivnntvydplqpeldsfkeeldkyfknhtspdv 1164 (1273) ++..|+.|+|+.+..+|++|.|++|+|..+|..|...-..|||...-++.++..|..|+.-.|++||+++|+|+++.-. T Consensus 441 ~~~~~~~~g~f~~~n~~~~iT~r~my~Pr~~t~~dfV~itSC~V~Y~Nvt~t~lp~viPdyiDfn~eLee~~~n~t~t~P 520 (605) T 6B3O_B 441 DRGLAPKAGYFVQDDGEWKFTGSSYYYPEPITDKNSVIMSSCAVNYTKAPEVFLNTSIPNPPDFKEELDKWFKNQTSIAP 520 (605) T ss_dssp SCEEEESSEEEEEETTEEEEEESSSCCCEECCTTSEEEESCSCCEEEECCCCCCCCCCCCCSCHHHHHTTTCCCCCCCCC T ss_pred CceEEecCeEEEeeCCeEEEeccccccCCCCCccceEEeeccccEEEecccccCCCCCCCCCChHHHHHHHHhcCCCCCC Confidence 7999999999999889999999999999999999999999999999999999999999999999999999999987444 Q sp|P0DTC2|SPIK 1165 DLG-DISGINASVVNIQKEIDRLNEVAKNLNESLIDLQEL 1203 (1273) Q Consensus 1165 dlg-disginasvvniqkeidrlnevaknlneslidlqel 1203 (1273) |+. |+.-+|+++.|+..||++|+++.|+||+++|||..- T Consensus 521 dl~~~ld~fN~T~LNLt~EI~~Lq~~i~~LN~s~IDL~~~ 560 (605) T 6B3O_B 521 DLSLDFEKLNVTLLDLTYEMNRIQDAIKKLNESYINLIKR 560 (605) T ss_dssp CCCCCGGGCCCCCCCCHHHHHHHHHHHHHTTTC------- T ss_pred CcCCCHHHccccccchHHHHHHHHHHHHHHHHHHHHHHHH Confidence 443 688999999999999999999999999999999754 No 21 >6PZ8_A S protein, G2 heavy chain; MERS-CoV, coronavirus, DPP4, receptor-binding, membrane; HET: MAN, NAG, BMA; 4.19A {Middle East respiratory syndrome-related coronavirus} Probab=100.00 E-value=8.5e-112 Score=897.44 Aligned_cols=445 Identities=43% Similarity=0.743 Sum_probs=424.4 Template_Neff=3.100 Q sp|P0DTC2|SPIK 694 AYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVE 773 (1273) Q Consensus 694 aytmslgaensvaysnnsiaiptnftisvtteilpvsmtktsvdctmyicgdstecsnlllqygsfctqlnraltgiave 773 (1273) .|++.+-. ..+.+++..|.||+||||+|++|.++++|.|.+|||.+|+||++.+|.+||.|||+||..+|++|.|.+.+ T Consensus 12 ~~~~p~~~-~~~~~~~~~i~IP~nFtl~v~~EyiQt~~~kV~IDC~~YVC~~~~~C~~LL~QYgs~C~~I~~aL~~~~~~ 90 (472) T 6PZ8_A 12 AFNHPIQV-DQLNSSYFKLSIPTNFSFGVTQEYIQTTIQKVTVDCKQYVCNGFQKCEQLLREYGQFCSKINQALHGANLR 90 (472) T ss_dssp CCCCCEEC-CCCCTTEEEEEECCEEEEEEEEEEEECCCCCEEECHHHHHSSSCHHHHHHHGGGHHHHHHHHHHHHHHHHH T ss_pred eccCCcee-ccccCCCeeEEeccceEEEEEEEEEEecCCceEEechhhccCCCHHHHHHHHHHHHHHHHHHHHHHHHHhh Confidence 56666554 67788899999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 774 QDKNTQEVFAQVKQIYKTPPIKDF-GGFNFSQILPDPS---KPSKRSFIEDLLFNKVTLADAGFIKQYGDCLGDI--AAR 847 (1273) Q Consensus 774 qdkntqevfaqvkqiyktppikdf-ggfnfsqilpdps---kpskrsfiedllfnkvtladagfikqygdclgdi--aar 847 (1273) +|....+++...++-+..|-+..| |+|||+.++|.+. ++++||+||||||+||..+|.|+.+.|..|.... ..| T Consensus 91 ~d~~~~~~~s~~~~~~~~~~~~~~~g~fN~s~ll~~~~~~~~~~~RS~IEDLLF~KV~t~glG~~~~Yk~Ct~~~g~~i~ 170 (472) T 6PZ8_A 91 QDDSVRNLFASVKSSQSSPIIPGFGGDFNLTLLEPVSISTGSRSARSAIEDLLFDKVTIADPGYMQGYDDCMQQGPASAR 170 (472) T ss_dssp HHHHHHHHHHHHCCSEECCCCTTTTTTSCCTTSCCC--------CCCHHHHHHHHHSCCCCCCSSSCGGGGSSSSCTTCC T ss_pred ccHHHHHHHHhccccccCCCcCCCCCCcccceeccCcCCCCCCcceeHHHHHHcCceeecCCcchHhHHHHHhcCCccHH Confidence 999999999999999988887777 5799999999775 4458999999999999999999999999999544 899 Q sp|P0DTC2|SPIK 848 DLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQF 927 (1273) Q Consensus 848 dlicaqkfngltvlpplltdemiaqytsallagtitsgwtfgagaalqipfamqmayrfngigvtqnvlyenqklianqf 927 (1273) ||+|||.|||+.||||.+++||++.||++|.+|....|||+|..+|..||||+||.||+||+|+||+||.||||+|||.| T Consensus 171 DL~CaQyyNGi~VLPpv~d~~~~a~YTasL~g~ma~gg~T~GitsaaaIPFa~~vq~RlN~v~lt~~VL~~NQk~iA~sF 250 (472) T 6PZ8_A 171 DLICAQYVAGYKVLPPLMDVNMEAAYTSSLLGSIAGVGWTAGLSSFAAIPFAQSIFYRLNGVGITQQVLSENQKLIANKF 250 (472) T ss_dssp CTTTTHHHHTEEECCCSSHHHHHHHHHHHHHTTCSCSCSSCCSSCBCCCCHHHHHHHHHHTTTCCHHHHHHHHHHHHHHH T ss_pred HHhcccccCcEEEeCCCCCHHhHHHHHHHHHHHHHhcchhccchhhccCchHHHHHHHhhhhcccHHHHHHHHHHHHHHH Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 928 NSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTY 1007 (1273) Q Consensus 928 nsaigkiqdslsstasalgklqdvvnqnaqalntlvkqlssnfgaissvlndilsrldkveaevqidrlitgrlqslqty 1007 (1273) |.|||.||+.++++++||.|+|||||++++||++|++||+.|||||||.++||++|||++||++|+||||+|||.+|.+| T Consensus 251 N~Aig~iq~gf~tt~~AL~KiQ~VVN~q~~aL~~L~~qL~nnFgAISssI~dIy~RLD~leAdaQVDRLItGRL~aLnaf 330 (472) T 6PZ8_A 251 NQALGAMQTGFTTTNEAFHKVQDAVNNNAQALSKLASELSNTFGAISASIGDIIQRLDVLEQDAQIDRLINGRLTTLNAF 330 (472) T ss_dssp HHHHHTHHHHSSTTCHHHHHHHHHHHHHHHHHHHHHHGGGCCSSSSCSCHHHHHHHSCHHHHHHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHchHHHHHHHHHHHHHHHHHHHHHHHHHHhHHHHHHHH Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 1008 VTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHD--- 1084 (1273) Q Consensus 1008 vtqqliraaeirasanlaatkmsecvlgqskrvdfcgkgyhlmsfpqsaphgvvflhvtyvpaqeknfttapaichd--- 1084 (1273) |+|+|.|++|+|+++.||..|+.|||..||+|.+|||.|.|++|+||.||+|++|+|.+|+|.+..+.++.|.+|++ T Consensus 331 Vsq~l~~~~~v~~sr~LA~qKiNECVKSQS~R~gFCGnGtHi~Si~q~APnGi~F~H~~y~Pt~~~~V~a~~GlC~~~~~ 410 (472) T 6PZ8_A 331 VAQQLVRSESAALSAQLAKDKVNECVKAQSKRSGFCGQGTHIVSFVVNAPNGLYFMHVGYYPSNHIEVVSAYGLCDAANP 410 (472) T ss_dssp HHHHHHHHHHHHHHHHHHHHHCCCCCSSCCCCSSSSSSSSCEEEEEEEETTEEEEEEEEEEEECCEEEEEESCEEETTEE T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHhcccccCCCCCCeeEEEEeeccCCeEEEEEEEEccCceeEEEEEeEEeecCCC Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999995 Q sp|P0DTC2|SPIK 1085 GKAHFPREGVFVSNG-----THWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDP 1140 (1273) Q Consensus 1085 gkahfpregvfvsng-----thwfvtqrnfyepqiittdntfvsgncdvvigivnntvydp 1140 (1273) +++..|+.|+|+.+. ++|++|.|++|+|..||.+|+.. -.|||....+|+++++| T Consensus 411 ~~~~~p~~g~fv~~n~t~~~~~w~~T~r~~Y~P~~iT~~n~v~-~sc~vny~nv~~~~~~p 470 (472) T 6PZ8_A 411 TNCIAPVNGYFIKTNNTRIVDEWSYTGSSFYAPEPITSLNTKY-VAPQVTYQNISTNLPPP 470 (472) T ss_dssp EEEEEESSEEEEECCCTTCCSSEEEEESSSCCCEECCGGGEEE-CCCCTTSEEESSCCCTT T ss_pred CceEeecCceEEEeCCccccceEEEeccccccCcCCCccceEE-ecCcceEEEccccCCCC Confidence 578999999999866 46999999999999999999888 78899999999999998 No 22 >6PZ8_F S protein, G2 heavy chain; MERS-CoV, coronavirus, DPP4, receptor-binding, membrane; HET: BMA, MAN, NAG; 4.19A {Middle East respiratory syndrome-related coronavirus} Probab=100.00 E-value=3.1e-74 Score=636.33 Aligned_cols=621 Identities=20% Similarity=0.314 Sum_probs=345.6 Template_Neff=4.300 Q sp|P0DTC2|SPIK 14 QCVNL-TTRTQLPPAYT----NSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNG--T-------KRF 79 (1273) Q Consensus 14 qcvnl-ttrtqlppayt----nsftrgvyypdkvfrssvlhstqdlflpffsnvtwfhaihvsgtng--t-------krf 79 (1273) .|... -...-+++.++ -+-.+|+||||..++++..+-.|+||.+.-++.+-.- ++|++. + -.+ T Consensus 12 ~C~~~~~~~~~~~~~~s~~idvs~~~G~yYp~~rvysN~tll~~glfp~~gs~~~~y~---~~~~~~~~~~~~~~~~~~y 88 (726) T 6PZ8_F 12 ACIEVDIQQTFFDKTWPRPIDVSKADGIIYPQGRTYSNITITYQGLFPYQGDHGDMYV---YSAGHATGTTPQKLFVANY 88 (726) T ss_dssp BCCCEEECGGGGCCCCCCCCCGGGTTTCBCCSSCEECSEEEEEEEEECCTTCCCEEEC---CEECCBCSSSBCSEEECSC T ss_pred ceEEecccccccCCCCCcceecccCceeEeeCCeeEeeeeeeecccccCCCCcceEEE---EeecCCCCCCCccceeecC Confidence 36655 23334445555 3446899999999999999999999999988876532 333332 2 356 Q sp|P0DTC2|SPIK 80 DNPVLPFNDGVYFASTEKSNIIR-----------------GWIFGTTLDSKT---Q------SLLIVNNATNVVI----- 128 (1273) Q Consensus 80 dnpvlpfndgvyfasteksniir-----------------gwifgttldskt---q------sllivnnatnvvi----- 128 (1273) +.+..||+||+++...+..|.-. .++||+|.+... + +++|+++-.+.++ T Consensus 89 ~~~~~~F~dGifvkv~~~~n~t~~~~~~~~~~~~~~~~ypa~~fGstf~n~s~~~~~~~~~~tlvI~P~~~g~~~~~~~c 168 (726) T 6PZ8_F 89 SQDVKQFANGFVVRIGAAANSTGTVIISPSTSATIRKIYPAFMLGSSVGNFSDGKMGRFFNHTLVLLPDGCGTLLRAFYC 168 (726) T ss_dssp TTCCEECTTCEEEEECTTTTCEEECSSSTTCEEEEECCCCCEEEESCEECCTTSCSCEECSEEEEEEEETTTTEEEEEEE T ss_pred CCChHHccCeEEEEEeeeeccCCCeeeCCCcccchhhcccceEEeccccCCCCccceeeeceEEEEecCCCCccceeeee Confidence 77889999999998887666532 256999998766 6 8999999887654 Q sp|P0DTC2|SPIK 129 --KVCEFQFCNDPFLGVYYHKNN---KSWME---------SEFRVYSSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVF 194 (1273) Q Consensus 129 --kvcefqfcndpflgvyyhknn---kswme---------sefrvyssannctfeyvsqpflmdlegkqgnfknlrefvf 194 (1273) ...+..-|..|..-+++.-+. .+|-. -+++.|....||+|.|. +.|-+|... ..|- |.| T Consensus 169 ~~~prt~t~C~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~c~~~~~-~nft~d~~~--~wf~----~~F 241 (726) T 6PZ8_F 169 ILEPRSGNHCPAGNSYTSFATYHTPATDCSDGNYNRNASLNSFKEYFNLRNCTFMYT-YNITEDEIL--EWFG----ITQ 241 (726) T ss_dssp EEEECCSBTSTTSTTCCCCCEEECHHHHEETTEECTTHHHHHHHHHEEEEEEEEEEE-EECCCCCCC--EEEE----EEE T ss_pred ecccCccccCCCCCeEeeecccCCCCccCCCCcccccccccchhhheecCCcEEEEe-eecCcchhh--heEE----EEE Confidence 323344555666655542221 23422 36788899999999875 344333211 1111 999 Q sp|P0DTC2|SPIK 195 KNID-GYFKIYSKHTPINL---VRDLPQGFSALEPLVDLPIGINITRFQTLLALHRSYLTPGDSSSGWTAGAAAYYVGYL 270 (1273) Q Consensus 195 knid-gyfkiyskhtpinl---vrdlpqgfsaleplvdlpiginitrfqtllalhrsyltpgdsssgwtagaaayyvgyl 270 (1273) +..| |.|-+|..++..+. ..-+| |...+.+.. .+-|+..++ .+.+. .-++|||++| T Consensus 242 ~~~~~G~f~~Y~~d~~~~~~f~f~~~~-~~~~~~yy~---------------vip~~~~~~---~~~~~-~~~~~yV~~L 301 (726) T 6PZ8_F 242 TAQGVHLFSSRYVDLYGGNMFQFATLP-VYDTIKYYS---------------IIPHSIRSI---QSDRK-AWAAFYVYKL 301 (726) T ss_dssp ETTEEEEEESTTTCTTTCCBEEEEEEC-CCSCCCEEE---------------ECCEEECCC---GGGCC-EECCEEEEEC T ss_pred eeCCceeEEEEEEecCCCcceeccccc-ceeccceee---------------eeeeeecCC---cccce-eEEEEEEEEc Confidence 9999 99999877655442 22233 444444443 333444444 45566 7889999999 Q sp|P0DTC2|SPIK 271 QPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASV 350 (1273) Q Consensus 271 qprtfllkynengtitdavdcaldplsetkctlksftvekgiyqtsnfrvqptesivrfpnitnlcpfgevfnatrfasv 350 (1273) .+|+|||+|+.||.|++||||+-|+++|-||..+||.+++|+|++|+||+||....+|.++. ..|+|.++++ .++.++ T Consensus 302 ~~~~yLl~Fd~nG~It~AvDCa~d~~sEL~Cst~Sf~p~tGVY~lS~y~aqP~g~V~~~~~~-~~C~~~~~~~-~~~Psp 379 (726) T 6PZ8_F 302 QPLTFLLDFSVDGYIRRAIDCGFNDLSQLHCSYESFDVESGVYSVSSFEAKPSGSVVEQAEG-VECDFSPLLS-GTPPQV 379 (726) T ss_dssp EEEEEEEEECTTSCEEEEEETTSSHHHHHHHHTSSSSSSCSCEEEEEECCCCEEEEEECCC------------------- T ss_pred ccceEEEecCCCCeEEEEEeccCCccccceeEeeeecCCCCeeecCcEEEEeeeEEEEecCC-CCCCChHHhc-CCCCCc Confidence 99999999999999999999999999999999999999999999999999999999999999 9999999999 889999 Q sp|P0DTC2|SPIK 351 YAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFT 430 (1273) Q Consensus 351 yawnrkrisncvadysvlynsasfstfkcygvsptklndlcftnvyadsfvirgdevrqiapgqtgkiadynyklpddft 430 (1273) +.|.|+.++||..|+++|++....+.|+||||+|.||.+.||..|++|.|.|..+..++++||++|-|++||||+|++|+ T Consensus 380 ~~w~R~~fsNCnfN~s~Lls~~~~~~f~C~gIspskLa~mCfsSvtiD~Faip~s~~~~L~~g~~g~i~~yNYkld~~~~ 459 (726) T 6PZ8_F 380 YNFKRLVFTNCNYNLTKLLSLFSVNDFTCSQISPAAIASNCYSSLILDYFSYPLSMKSDLSVSSAGPISQFNYKQSFSNP 459 (726) T ss_dssp -------------------------------------------------------------------------------- T ss_pred ceeeEEEEecccccHHHHHhccceeeeeecCCCHHHHhhhccceeeEEEEEcchhhccccCCCCCccchhccccCCCCCC Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 431 GCVIAWNSNNLDSK--VGGNYNYLYRLFRKSNLKPFERDISTEIYQAG--STPCN--GVEGFNCYFPLQS---------- 494 (1273) Q Consensus 431 gcviawnsnnldsk--vggnynylyrlfrksnlkpferdisteiyqag--stpcn--gvegfncyfplqs---------- 494 (1273) ||+++|+-.+++.. --.+|+|+-|-.+... ++. +++-|-- .+-|+ ... -+|+.+... T Consensus 460 ~C~l~~~~~~~~~n~t~~~~~~~i~~~~~~~~-----~~~-~~~~~~~~~~~~cpc~~~~-~~~~~~~~~~~~~~~~~~~ 532 (726) T 6PZ8_F 460 TCLILATVPHNLTTITKPLKYSYINKCSRLLS-----DDR-TEVPQLVNANQYSPCVSIV-PSTVWEDGDYYRKQLSPLE 532 (726) T ss_dssp -------------------------------------------------------------------------------- T ss_pred ceEEEEEcCcccccCCCcccceeeeeeccCCC-----CCC-cchhhhccccccCCCcccC-CccccCCCCcccccccccc Confidence 99999985442222 2567777776666443 222 2221100 11111 000 112221111 Q sp|P0DTC2|SPIK 495 -YGFQP----TNGVGYQPYRVVVLSFELLHAPATVCGPK-----KSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQ 564 (1273) Q Consensus 495 -ygfqp----tngvgyqpyrvvvlsfellhapatvcgpk-----kstnlvknkcvnfnfngltgtgvltesnkkflpfqq 564 (1273) -+..+ ..++++|.+.+++++++..-.+.|||..+ ..++++.++||++|..|.+|+||++++|..+...+. T Consensus 533 ~~~~~~~~~~~~~~~~~c~~lvvIt~~~gs~~~TvcP~~~~~~~~~s~i~l~~Cv~YnIYG~tG~GvI~~~n~~~~~gl~ 612 (726) T 6PZ8_F 533 GGGWLVASGSTVAMTEQLQMGFGITVQYGTDTNSVCPKLEFANDTKIASQLGNCVEYSLYGVSGRGVFQNCTAVGVRQQR 612 (726) T ss_dssp -------------------------------------------CCSCSCCCSSSEEEEETTEEEEECEEECCCCSCTTSC T ss_pred CCccccccccceecccceeEEEEEEeecCCCccccccccccccCCceeeeeCeeeeEEeCCceeeEEEEecCeeeeCCEE Confidence 12222 34889999999999999999999999442 247999999999999999999999999999999999 Q sp|P0DTC2|SPIK 565 FGRDIADTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRV--YSTGSNV 642 (1273) Q Consensus 565 fgrdiadttdavrdpqtleilditpcsfggvsvitpgtntsnqvavlyqdvnctevpvaihadqltptwrv--ystgsnv 642 (1273) +..+.+.-.-++++ .++++..|+||..+.++++..|+ ++.++.||..++|+.+....+..+.+|.||+ +++..+. T Consensus 613 ~~~s~sg~l~~fk~-~~g~~Y~V~PC~~v~~qvvv~~~--s~~~vgl~ts~nc~~v~~~~~~~~~s~~~~~~~~~~~~~~ 689 (726) T 6PZ8_F 613 FVYDAYQNLVGYYS-DDGNYYCLRACVSVPVSVIYDKE--TKTHATLFGSVACEHISSTMSQYSRSTRSMLKRRDSTYGP 689 (726) T ss_dssp EEECTTSCEEEEEC-TTSCEEEECCCCCEEEEEEEETT--TTEEEEECGGGCGGGCCSSCSSCSSSCCHHHHHHHTTSCC T ss_pred EEecCCCCEEEEEe-CCCCEEEEecCcccceeEEEeCC--CCCEEEEEecccCccccccceeeccCCchhcccccCCCCC Confidence 97788888999999 99999999999999999999997 7889999999999999999999999999998 8888899 Q sp|P0DTC2|SPIK 643 FQTRAGCLIGAEHVNN-SYECDIPIGAGICASYQT 676 (1273) Q Consensus 643 fqtragcligaehvnn-syecdipigagicasyqt 676 (1273) |||-+||++||++.+. ..|||+|+|+|+||.|.+ T Consensus 690 fdT~~GCV~na~n~t~~V~~C~LplG~slC~~~~~ 724 (726) T 6PZ8_F 690 LQTPVGCVLGLVNSSLFVEDCKLPLGQSLCALPDT 724 (726) T ss_dssp EECSSCEEETCCEEEEEESCCSSEEETTEEEECCC T ss_pred CCCchheeeeeecCCCceeeCCCCCCcceecCCCC Confidence 9999999999999998 999999999999999976 No 23 >7BZ5_A Spike protein S1, Heavy chain; covid-19 antibody, VIRAL PROTEIN, VIRAL; HET: NAG; 1.84A {Severe acute respiratory syndrome coronavirus 2} Probab=100.00 E-value=3.5e-52 Score=416.50 Aligned_cols=225 Identities=99% Similarity=1.598 Sum_probs=190.3 Template_Neff=4.100 Q sp|P0DTC2|SPIK 319 RVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYAD 398 (1273) Q Consensus 319 rvqptesivrfpnitnlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptklndlcftnvyad 398 (1273) |+||...++|++++++.|+|.++|+|.++.++|+|.|+.++||..|+++|++..++++|+||||||+||.++||.+|++| T Consensus 1 raqP~g~V~r~~~~~~~C~~~~~l~~~~~Psp~nW~R~~fsNCnfn~s~Lls~~~~~sf~C~gIspskL~~mCfsSvtiD 80 (229) T 7BZ5_A 1 RVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYAD 80 (229) T ss_dssp ---------------CBCCHHHHHTCSSCCBGGGCEEEEECSEECCCHHHHSCSCCSEEEEESSCSTTCTTCEESEEEEE T ss_pred CcccceEEEECCCCCCCCChHHHhcCCCCCCchheEEeEEecCCCcHHHHhhcceeceeeEeCCCHHHHcccccCeeEEE Confidence 78999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 399 SFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGST 478 (1273) Q Consensus 399 sfvirgdevrqiapgqtgkiadynyklpddftgcviawnsnnldskvggnynylyrlfrksnlkpferdisteiyqagst 478 (1273) .|.|+++++++++||++|.|++||||||+||+||+|+|+..+++..+.++|||++|.+++++++|||||++.++|+++.+ T Consensus 81 ~Faip~s~~~~L~~G~sG~i~~yNYKlp~~f~gC~l~~~~~~~~~~vt~~~~y~~rr~~~~~~~~f~~~~~~~~y~~~~~ 160 (229) T 7BZ5_A 81 SFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGST 160 (229) T ss_dssp EEEEEGGGGGGSSTTCCSHHHHHTCCCCTTCCEEEEEEECHHHHCCTTCBCCCEEECCCSSCCCTTCCCCCCCCEECSSS T ss_pred EEEecccceeecCCCCCcHHHhcccCCCCCCCCeEEEEEeCCcccccccchHHHHHhccccCCCccccCCccceeccCCC Confidence 99999999999999999999999999999999999999999999888899999999999999999999999999999999 Q sp|P0DTC2|SPIK 479 PCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNF 543 (1273) Q Consensus 479 pcngvegfncyfplqsygfqptngvgyqpyrvvvlsfellhapatvcgpkkstnlvknkcvnfnf 543 (1273) .|++..+.+|+.|+..|++|++.|+|+|+|+|+|++++...+++|||++|.+|++++++||||.. T Consensus 161 ~c~~~~~~~c~~p~~~~~~~~~~g~g~~c~g~~Vis~k~~~~s~TVC~~~~~T~~v~g~~~~~~~ 225 (229) T 7BZ5_A 161 PCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFHH 225 (229) T ss_dssp CCTTCCBTTEECSEEECCBCTTBCGGGSEEEEEEEEEECC-CCCCEECCC--------------- T ss_pred CCCCCCcccceeccCCCCCcccccccccceEEEEEEEEccCCCCccCCCCCCHHHhcCeeecCCC Confidence 99955599999999999988899999999999999999999999999999999999999999964 No 24 >6YZ5_E Spike glycoprotein, Nanobody H11-D4; nanobody, complex, SARS-Cov-2, VIRAL PROTEIN; HET: NAG, EDO, ACT; 1.8A {Severe acute respiratory syndrome coronavirus 2} Probab=100.00 E-value=3.5e-51 Score=405.64 Aligned_cols=205 Identities=99% Similarity=1.601 Sum_probs=193.3 Template_Neff=3.900 Q sp|P0DTC2|SPIK 330 PNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQ 409 (1273) Q Consensus 330 pnitnlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptklndlcftnvyadsfvirgdevrq 409 (1273) ||+++.|+|.++|+|.++.|+|+|.|+.++||+.|+|+|+++.++++|+||||||+||.++||.+|++|.|.|+++++++ T Consensus 1 ~~~~~~C~~~~~l~~~~~Psp~nWeR~~fsNCnfNlS~Lls~~~~~sF~C~gIspskLa~mCfsSVtiD~Faip~s~~~d 80 (210) T 6YZ5_E 1 PNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQ 80 (210) T ss_dssp ----CBCCHHHHHTCSSCCBGGGCEEEEECSEECCTHHHHTCSSCSEEEEESCCHHHHTTCEESEEEEEEEEEEGGGGGG T ss_pred CCCcCCCCHHHHhcCCCCCCchheEEeEEecCCCcHHHHhhcceeceeeeeCCCHHHHcccccCeeEEEEEEecccceee Confidence 78899999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 410 IAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCY 489 (1273) Q Consensus 410 iapgqtgkiadynyklpddftgcviawnsnnldskvggnynylyrlfrksnlkpferdisteiyqagstpcngvegfncy 489 (1273) ++||++|.|++||||||+||+||+|+|+..+++..+.++|||++|.+++++++||||+++.++|+++.+.|++..+.||+ T Consensus 81 Lq~G~sG~i~~yNYKlp~~f~gC~l~~~~~~~~vnvts~yny~~rr~~~~~~~~f~~~~~~~~y~~~~~~c~~~~~~~c~ 160 (210) T 6YZ5_E 81 IAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCY 160 (210) T ss_dssp SSTTCCSHHHHHTCCCCTTCCEEEEEEECHHHHCCTTCBCCCEEECCCSSCCCTTCCCCCCCCEECSSSCCTTCCBTTEE T ss_pred cCCCCCcHHHhcccCCCCCCCCeEEEEEeCCccccccccHHHHHHhcccCCCCccccccccchhccCCCCCCCCccccce Confidence 99999999999999999999999999999999999999999999999999999999999999999999999955599999 Q sp|P0DTC2|SPIK 490 FPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLV 534 (1273) Q Consensus 490 fplqsygfqptngvgyqpyrvvvlsfellhapatvcgpkkstnlv 534 (1273) .|+..|++|.+.|+|+|+|+|+|++++.+++|+||||||+|||.- T Consensus 161 ~p~~~~~~~~~~g~g~~c~gv~Vis~k~~~~~~t~~~~~~~~~~~ 205 (210) T 6YZ5_E 161 FPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNKH 205 (210) T ss_dssp CSEEECCBCTTSCGGGSEEEEEEEEEECCSSCCCEECCCCT---- T ss_pred ecccCCCCCCcccCCccceEEEEEEEEcCCCceEEeCcccccCCC Confidence 999998988899999999999999999999999999999999853 No 25 >6YLA_E SARS-CoV-2 RBD, Heavy Chain, Light; SARS-CoV-2 Spike protein, RBD, CR3022; HET: DMS, MLI, 1PE, NAG; 2.42A {Severe acute respiratory syndrome coronavirus 2} Probab=100.00 E-value=3.8e-51 Score=406.04 Aligned_cols=207 Identities=98% Similarity=1.577 Sum_probs=201.0 Template_Neff=3.900 Q sp|P0DTC2|SPIK 328 RFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEV 407 (1273) Q Consensus 328 rfpnitnlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptklndlcftnvyadsfvirgdev 407 (1273) .||++++.|+|.++|||.++.|+|+|.|+.++||+.|+|+|+++.++++|+||||||+||.++||.+|++|.|.|+++++ T Consensus 2 ~~~~~~~~C~~~~~l~~~~~Psp~nWeR~~fsNCnfNlS~Lls~~~~~sF~C~gIspskLa~mCfsSVtiD~Faip~s~~ 81 (213) T 6YLA_E 2 TGPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEV 81 (213) T ss_pred CCCCCcCCCCHHHHhcCCCCCCchheEEeEEecCCCcHHHHhhcceeceeeeeCCCHHHHcccccCeeEEEEEEecccce Confidence 47999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 408 RQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFN 487 (1273) Q Consensus 408 rqiapgqtgkiadynyklpddftgcviawnsnnldskvggnynylyrlfrksnlkpferdisteiyqagstpcngvegfn 487 (1273) ++++||++|.|++||||||+||+||+|+|+..+++..+.++|||++|.+++++++||||+++.++|+++.+.|++..+.| T Consensus 82 ~dLq~G~sG~i~~yNYKlp~~f~gC~l~~~~~~~~vnvts~yny~~rr~~~~~~~~f~~~~~~~~y~~~~~~c~~~~~~~ 161 (213) T 6YLA_E 82 RQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFN 161 (213) T ss_pred eecCCCCCcHHHhcccCCCCCCCCeEEEEEeCCccccccccHHHHHHhcccCCCCccccccccchhccCCCCCCCCcccc Confidence 99999999999999999999999999999999999999999999999999999999999999999999999999555999 Q sp|P0DTC2|SPIK 488 CYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLV 534 (1273) Q Consensus 488 cyfplqsygfqptngvgyqpyrvvvlsfellhapatvcgpkkstnlv 534 (1273) ||.|+..|++|.+.|+|+|+|+|+|++++.+++|+||||||+|||.- T Consensus 162 c~~p~~~~~~~~~~g~g~~c~gv~Vis~k~~~~~~t~~~~~~~~~~~ 208 (213) T 6YLA_E 162 CYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNKH 208 (213) T ss_pred ceecccCCCCCCcccCCccceEEEEEEEEcCCCceEEeCcccccCCC Confidence 99999998988899999999999999999999999999999999853 No 26 >6ZFO_A SARS-CoV-2 RBD, Nanobody, EY6A heavy; EY6a, RBD, Spike glycoprotein, SARS-CoV-2; HET: NAG;{Severe acute respiratory syndrome coronavirus 2} Probab=100.00 E-value=2.3e-47 Score=375.21 Aligned_cols=194 Identities=100% Similarity=1.634 Sum_probs=189.3 Template_Neff=4.100 Q sp|P0DTC2|SPIK 333 TNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAP 412 (1273) Q Consensus 333 tnlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptklndlcftnvyadsfvirgdevrqiap 412 (1273) |+.|+|.++|||.++.++|+|.||.++||+.|+|+|+++.++++|+||||+|+||.++||.+|++|.|.|+++++++++| T Consensus 1 ~~~C~~~~~l~~~~~Psp~nWeR~~fsNCnfn~S~Lls~~~~~sf~C~gIspskL~~mCfsSvtiD~Faip~s~~~~L~~ 80 (194) T 6ZFO_A 1 TNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAP 80 (194) T ss_dssp CCBCCCHHHHSCSSCCCSTTCEEEEECSEECCTHHHHHCCCCSEEEEESSCSGGGTTCCBSEEEEEEEEEEHHHHTTSST T ss_pred CCCCCHHHhhccCCCCCchheEEeEEecCCCcHHHHhhcceeceeeeeCCCHHHHcccccCeeEEEEEEecccceeecCC Confidence 57899999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 413 GQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPL 492 (1273) Q Consensus 413 gqtgkiadynyklpddftgcviawnsnnldskvggnynylyrlfrksnlkpferdisteiyqagstpcngvegfncyfpl 492 (1273) |++|.|++||||||+||+||+|+|+..+++..+.++|||++|.+++++++||||+++.++|+++.+.|++..+.||+.|+ T Consensus 81 G~sG~i~~yNYKlp~~f~gC~l~~~~~~~~~nvt~~y~y~~~~~~~~~~~~f~~~~~~~~y~~~~~~c~~~~~~~c~~p~ 160 (194) T 6ZFO_A 81 GQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPL 160 (194) T ss_dssp TCCSHHHHHTCCCCTTCCEEEEEEECTTTSCCTTCBCCCEEECCCSSCCCTTCCCCCCCCEECSSSCCSSCCBTTEECSE T ss_pred CCCcHHHhcccCCCCCCCCeEEEEEeCCccccccccHHHHHHhcccCCCCccccccccchhccCCCCCCCCccccceecc Confidence 99999999999999999999999999999999999999999999999999999999999999999999955599999999 Q sp|P0DTC2|SPIK 493 QSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCG 526 (1273) Q Consensus 493 qsygfqptngvgyqpyrvvvlsfellhapatvcg 526 (1273) ..|++|++.|+|+|+|+|+|++++.+|+|+|||| T Consensus 161 ~~~~~~~~~g~g~~c~g~~Vis~k~~~~~~t~~~ 194 (194) T 6ZFO_A 161 QSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCG 194 (194) T ss_dssp EECCBCTTSCTTTSEEEEEEEEEECCSSCCCEEC T ss_pred cCCCCCCcccCCccceEEEEEEEEcCCCcceecC Confidence 9989888999999999999999999999999998 No 27 >2GHV_C Spike glycoprotein; SARS, S protein, VIRAL PROTEIN; 2.2A {SARS coronavirus} SCOP: d.318.1.1 Probab=100.00 E-value=3.9e-37 Score=305.00 Aligned_cols=197 Identities=71% Similarity=1.226 Sum_probs=171.8 Template_Neff=4.000 Q sp|P0DTC2|SPIK 330 PNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQ 409 (1273) Q Consensus 330 pnitnlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptklndlcftnvyadsfvirgdevrq 409 (1273) |+++..|+|.++|+|.++.++|+|.|+.++||..|+|+|++..++++|+||||||+||.++||..|++|.|.|..+++++ T Consensus 4 ~~~~~~C~~~~~l~~~~~Psp~nWeR~~fsNCnfnls~Lls~~~~~sf~C~gIspskLa~mCfsSvtiD~Faip~s~~~~ 83 (203) T 2GHV_C 4 PNITNLCPFGEVFNATKFPSVYAWERKKISNCVADYSVLYNSTFFSTFKCYGVSATKLNDLCFSNVYADSFVVKGDDVRQ 83 (203) T ss_dssp ---CCBCCCHHHHSCSSCCBGGGCEEEEECSSBCCGGGSCSCCBCSEEEEESCBGGGGGGGGCSSEEEEEEEEEGGGGGG T ss_pred CCccCCCCHHHHhcCCCCCCcceeEEeEEecCCCCHHHHhhccccceeeeeCCCHHHHcccccCeeEEEEEEeccchhhh Confidence 67789999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 410 IAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCY 489 (1273) Q Consensus 410 iapgqtgkiadynyklpddftgcviawnsnnldskvggnynylyrlfrksnlkpferdisteiyqagstpcngvegfncy 489 (1273) ++||++|-|++||||||+||+||+++|+-.+++..+.+|||+.++-.|...++|+++|++.-.+-.+..||....-.+|+ T Consensus 84 Lq~G~sG~i~~yNYKlp~~f~gC~l~~~~~~~~vn~t~~~nps~~~~r~~~~~~~~~~~c~c~~~~~~~~c~~~~~~~p~ 163 (203) T 2GHV_C 84 IAPGQTGVIADYNYKLPDDFMGCVLAWNTRNIDATSTGNYNYKYRYLRHGKLRPFERDISNVPFSPDGKPCTPPALNCYW 163 (203) T ss_dssp SSTTCCSHHHHHTCCCCTTCCEEEEEEECHHHHCBTTCBCCCEEECCCSSCCCTTCCCCCCCCBCTTSCCCCTTSTTCBC T ss_pred cCCCCCcHHHhcccCCCCCCcceEEEEEeCccccccCCccCcccchhcccccccCCCccCCCCCCCCCCCCCCCCccccc Confidence 99999999999999999999999999999888888888788777665555689999999986664444566543333334 Q sp|P0DTC2|SPIK 490 FPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGP 527 (1273) Q Consensus 490 fplqsygfqptngvgyqpyrvvvlsfellhapatvcgp 527 (1273) .|-. +++..+.|+|+|+|+|+|++++.+.+|+||||- T Consensus 164 ~~~~-~~~~~~~g~g~~c~g~~Vis~k~~~~~~t~~~~ 200 (203) T 2GHV_C 164 PLND-YGFYTTTGIGYQPYRVVVLSFELLNAPATVSGL 200 (203) T ss_dssp CEEE-CCBBSSSCGGGSEEEEEEEEECSGGSTCBTTCC T ss_pred CCCc-CCceecccCCccceEEEEEEEEcCCCceEEeee Confidence 4322 556677899999999999999999999999994 No 28 >1WYY_A E2 Glycoprotein; membrane fusion, severe acute respiratory; 2.2A {SARS coronavirus} SCOP: h.3.3.1 Probab=100.00 E-value=2.3e-36 Score=288.46 Aligned_cols=99 Identities=89% Similarity=1.142 Sum_probs=83.9 Template_Neff=2.300 Q sp|P0DTC2|SPIK 903 AYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILS 982 (1273) Q Consensus 903 ayrfngigvtqnvlyenqklianqfnsaigkiqdslsstasalgklqdvvnqnaqalntlvkqlssnfgaissvlndils 982 (1273) +||+|++|++++||.||||+||+.||.|++.|+..++++++||.|+|||||++++||+.|+.||+.|||||||.++||.+ T Consensus 3 ~~RlNyvalqt~VLq~NQk~iA~sFN~Ai~~i~~gf~tts~AL~KIQdVVN~q~~aL~~Lt~QL~nNFgAISSSI~dIy~ 82 (149) T 1WYY_A 3 AYRFNGIGVTQNVLYENQKQIANQFNKAISQIQESLTTTSTALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILS 82 (149) T ss_dssp -----CCSCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred ccccchhhhcHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhHHHHHHHHHHH Confidence 69999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 983 RLDKVEAEVQIDRLITGRL 1001 (1273) Q Consensus 983 rldkveaevqidrlitgrl 1001 (1273) |||++||.+|+|||||||+ T Consensus 83 RLD~leAdaQVDRLItGR~ 101 (149) T 1WYY_A 83 RLDKVEAEVQIDRLITGGR 101 (149) T ss_dssp HHHHHHHHC---------- T ss_pred HHHHHHHHHHHHHHHhcCC Confidence 9999999999999999985 No 29 >1WYY_B E2 Glycoprotein; membrane fusion, severe acute respiratory; 2.2A {SARS coronavirus} SCOP: h.3.3.1 Probab=100.00 E-value=2.3e-36 Score=288.46 Aligned_cols=99 Identities=89% Similarity=1.142 Sum_probs=81.9 Template_Neff=2.300 Q sp|P0DTC2|SPIK 903 AYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILS 982 (1273) Q Consensus 903 ayrfngigvtqnvlyenqklianqfnsaigkiqdslsstasalgklqdvvnqnaqalntlvkqlssnfgaissvlndils 982 (1273) +||+|++|++++||.||||+||+.||.|++.|+..++++++||.|+|||||++++||+.|+.||+.|||||||.++||.+ T Consensus 3 ~~RlNyvalqt~VLq~NQk~iA~sFN~Ai~~i~~gf~tts~AL~KIQdVVN~q~~aL~~Lt~QL~nNFgAISSSI~dIy~ 82 (149) T 1WYY_B 3 AYRFNGIGVTQNVLYENQKQIANQFNKAISQIQESLTTTSTALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILS 82 (149) T ss_dssp -------CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred ccccchhhhcHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhHHHHHHHHHHH Confidence 69999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 983 RLDKVEAEVQIDRLITGRL 1001 (1273) Q Consensus 983 rldkveaevqidrlitgrl 1001 (1273) |||++||.+|+|||||||+ T Consensus 83 RLD~leAdaQVDRLItGR~ 101 (149) T 1WYY_B 83 RLDKVEAEVQIDRLITGGR 101 (149) T ss_dssp HHHHHHHHC---------- T ss_pred HHHHHHHHHHHHHHHhcCC Confidence 9999999999999999985 No 30 >5X4S_A Spike glycoprotein; SARS-CoV, spike, N-terminal domain, VIRAL; HET: NAG; 2.2A {Human SARS coronavirus} Probab=100.00 E-value=1.1e-34 Score=297.96 Aligned_cols=261 Identities=56% Similarity=1.068 Sum_probs=238.0 Template_Neff=4.200 Q sp|P0DTC2|SPIK 30 NSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNGTKRFDNPVLPFNDGVYFASTEKSNIIRGWIFGTT 109 (1273) Q Consensus 30 nsftrgvyypdkvfrssvlhstqdlflpffsnvtwfhaihvsgtngtkrfdnpvlpfndgvyfasteksniirgwifgtt 109 (1273) -|-.+|+||||..+||+..+-.|+||.++-++++-+|. .--.+++++.||+||+++...+++|.-++|+||+| T Consensus 21 ~s~~~G~yYPd~~~ysN~t~L~qglfp~~gs~~~~~~~-------~~~~y~~~~~~F~dGifv~v~~~~n~t~a~~fGst 93 (285) T 5X4S_A 21 TSSMRGVYYPDEIFRSDTLYLTQDLFLPFYSNVTGFHT-------INHTFDNPVIPFKDGIYFAATEKSNVVRGWVFGST 93 (285) T ss_pred cccCceeEecCCeeeecceeeeecccCCCCCCccccCC-------cceecCCCccccCCeEEEEeeeecCCCCceeeeec Confidence 34568999999999999999999999999999998555 23568899999999999999999999889999999 Q sp|P0DTC2|SPIK 110 LDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVYYHKNNKSWMESEFRVYSSANNCTFEYVSQPFLMDLEGKQGNFKNL 189 (1273) Q Consensus 110 ldsktqsllivnnatnvvikvcefqfcndpflgvyyhknnkswmesefrvyssannctfeyvsqpflmdlegkqgnfknl 189 (1273) .+.++++++|+++-+...|.+|.|+.|..|.+.++..-.| --++..|..+.||+|+|.|+.|-+|...+-.+.... T Consensus 94 f~N~s~tviI~p~~~~~~it~C~~~vC~~p~~~~~~~~g~----~~~~~~f~~~~nc~~~~~~~nfT~d~~~~~~~~~~r 169 (285) T 5X4S_A 94 MNNKSQSVIIINNSTNVVIRACNFELCDNPFFAVSKPMGT----QTHTMIFDNAFNCTFEYISDAFSLDVSEKSGNFKHL 169 (285) T ss_pred ccCCcEEEEEcCCCCcceEEEeEEEeCCCCeeEEcCCCCc----ccccceeeecCCCeEEEcccccccccCcceeeeeeE Confidence 9999999999999999999999999999999998874333 567888999999999999999999988888888889 Q sp|P0DTC2|SPIK 190 REFVFKNIDGYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHRSYLTPGDSSSGWTAGAAAYYVGY 269 (1273) Q Consensus 190 refvfknidgyfkiyskhtpinlvrdlpqgfsaleplvdlpiginitrfqtllalhrsyltpgdsssgwtagaaayyvgy 269 (1273) ++|+|++.||+|-+|....+.+..+.+|.|+..|.|..-+|..|+||.|...+ |.|-++ .+.|..+.++|||++ T Consensus 170 ~~f~F~~~dG~f~~Y~~~~~~~~f~~~p~~~~~l~yy~vip~s~~~~~~~~~~---~~~~~~---~~~~~~~~~a~yV~~ 243 (285) T 5X4S_A 170 REFVFKNKDGFLYVYKGYQPIDVVRDLPSGFNTLKPIFKLPLGINITNFRAIL---TAFSPA---QDTWGTSAAAYFVGY 243 (285) T ss_pred EEEEEEeeCCeEEEEEecCCCcccccCCCccccceeeEeeeeecccccccCCC---CCCCCC---CcccceeeEEEEEEe Confidence 99999999999999999888887999999999999999999999999997766 777776 678889999999999 Q sp|P0DTC2|SPIK 270 LQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFT 307 (1273) Q Consensus 270 lqprtfllkynengtitdavdcaldplsetkctlksft 307 (1273) |.||+|||+|++||+|++||||+-||++|-||..||-. T Consensus 244 L~~~t~Ll~fd~nG~It~AvDCa~~~~sELkCs~~~~~ 281 (285) T 5X4S_A 244 LKPTTFMLKYDENGTITDAVDCSQNPLAELKCSVKSHH 281 (285) T ss_pred cceeeEEEeecCCCeEeeEEEcccCcchhceeeecCCC Confidence 99999999999999999999999999999999998753 No 31 >5KWB_A Spike glycoprotein; Coronavirus spike protein, S1-CTD, receptor; HET: NAG, SUC; 1.91A {Human coronavirus HKU1 (isolate N1)} Probab=99.95 E-value=1.2e-33 Score=297.87 Aligned_cols=271 Identities=23% Similarity=0.387 Sum_probs=226.6 Template_Neff=3.700 Q sp|P0DTC2|SPIK 316 SNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNV 395 (1273) Q Consensus 316 snfrvqptesivrfpnitnlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptklndlcftnv 395 (1273) |+|||||...++|.+.....|+|.++++|.+..+++.|.||.++||..|+|+|++......|+|||++|.||.+.||..| T Consensus 1 S~y~vqP~g~V~r~~~~~~~C~~~~~l~~~~~Psp~nWeR~~fsNCnfNls~Lls~v~~~sf~C~~i~pskl~~mCfsSv 80 (371) T 5KWB_A 1 SGFTVKPVATVHRRIPDLPDCDIDKWLNNFNVPSPLNWERKIFSNCNFNLSTLLRLVHTDSFSCNNFDESKIYGSCFKSI 80 (371) T ss_dssp ----CCCCCSEEECCTTCCBCCHHHHHTCSEEECGGGCEEEEECSEEECHHHHHHHTEEEEEEEESSCGGGTTTCEESEE T ss_pred CCceeeeeeEEEEeCCCCCCCCHHHHHhCCCCCCccccEEeEEecCCCCHHHHHhhceeceeeeeCCCHHHhcccccCee Confidence 68999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 396 YADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGG----NYNYLYRLFRKSNLKPFERDISTE 471 (1273) Q Consensus 396 yadsfvirgdevrqiapgqtgkiadynyklpddftgcviawnsnnldskvgg----nynylyrlfrksnlkpferdiste 471 (1273) +.|.|.|..+..+++++|.+|-|++||||+|++|++|+++|+-..++..+.+ +|| |.++..+ |+...... T Consensus 81 tiD~Faip~s~~~dLq~g~sG~i~~~NYKid~~~~sC~l~y~~~~~nvt~t~~nps~~n---~ry~~~~---f~~~~hdv 154 (371) T 5KWB_A 81 VLDKFAIPNSRRSDLQLGSSGFLQSSNYKIDTTSSSCQLYYSLPAINVTINNYNPSSWN---RRYGFNN---FNLSSHSV 154 (371) T ss_dssp EEEEEECCGGGGGGGSTTCCSHHHHHTCCCCSSSCEEEEEEEEEGGGCEEECCCCCHHH---HHTTCCC---CCCCTTEE T ss_pred EEEEEecCcccchhccCCCCcHhHhccccCCCCCCceEEEEEcccceeeecCCCcccch---hhccccC---cCccccce Confidence 9999999999999999999999999999999999999999997665555443 454 2223222 55555555 Q sp|P0DTC2|SPIK 472 IYQ-----AGSTPCN---------------------------------------------GVEGFNCYFPLQSYGFQPTN 501 (1273) Q Consensus 472 iyq-----agstpcn---------------------------------------------gvegfncyfplqsygfqptn 501 (1273) +|. ++.+-|. +..++.|+-+...+.....- T Consensus 155 vYs~~cf~~~~~yCPC~~p~~~~~c~~~~~~~~~~~~~t~~r~c~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~q~~~~~ 234 (371) T 5KWB_A 155 VYSRYCFSVNNTFCPCAKPSFASSCKSHKPPSASCPIGTNYRSCESTTVLDHTDWCRCSCLPDPITAYDPRSCSQKKSLV 234 (371) T ss_dssp EEESCCEECCTTCCCSBCHHHHTTCCBSCCCBCBCCTTCCCCCEEEEEETTEEEEEEESSCSCTTTCSCGGGCSSEECCC T ss_pred eeeeeeeecCCCccCCCCccccccccCCCCCCCCCCCCccccccccccccccccccccccCCCCCcccCCCCccCceeee Confidence 554 2222221 11234455454444445567 Q sp|P0DTC2|SPIK 502 GVGYQPYRVVVLSFEL-----------------------------------------LHAPATVCGP---KKSTNLVKNK 537 (1273) Q Consensus 502 gvgyqpyrvvvlsfel-----------------------------------------lhapatvcgp---kkstnlvknk 537 (1273) |+|++.+.+.|++.+. .-.++|+|.. +..++++.++ T Consensus 235 gvg~~c~gl~v~~~kcg~~~~~~~~~C~C~~~af~gws~dsc~~~~~c~~f~n~~~~~~~T~t~cP~~~~~~~s~I~l~~ 314 (371) T 5KWB_A 235 GVGEHCAGFGVDEEKCGVLDGSYNVSCLCSTDAFLGWSYDTCVSNNRCNIFSNFILNGINSGTTCSNDLLQPNTEVFTDV 314 (371) T ss_dssp CTTCCCCCCCBCGGGBSBTTCCTTSBCCBCGGGBCSEEEEECEETTEEEEEEEEEEESTTCSSEEECSSCCCCCCCCCSS T ss_pred ccccccceEEEeeeeccCCCCCCCcccccCCCccccccccccccCCceeeccceeccCCCCCCcCCCcccCCCceEEeCe Confidence 9999999999999998 5668999998 6779999999 Q sp|P0DTC2|SPIK 538 CVNFNFNGLTGTGVLTE-SNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSF 592 (1273) Q Consensus 538 cvnfnfngltgtgvlte-snkkflpfqqfgrdiadttdavrdpqtleilditpcsf 592 (1273) ||++|..|.+|+|++++ +++.++..|.+..+.+.-..+++++.++++..|+||.. T Consensus 315 CVdYnIYG~tGqGvItnvT~~~~l~~~gL~yS~sgdl~~fk~~~tg~~Y~V~PC~~ 370 (371) T 5KWB_A 315 CVDYDLYGITGQGIFKEVSAVYYNSWQNLLYDSNGNIIGFKDFVTNKTYNIFPCYA 370 (371) T ss_dssp EEEEEETTEEEEEEEEEECGGGCCCSSSEEECTTSCEEEEECTTTCCEEEEECC-- T ss_pred eeeEEeCCCeeeEEEEeccCceeecCCcEEEcCCCCEEEEEcCCCCcEEEEeeccc Confidence 99999999999999999 99889999999999999999999999999999999975 No 32 >6LXT_F Spike protein S2; 2019-nCoV, HR1 and HR2 domain; HET: PG4; 2.9A {Severe acute respiratory syndrome coronavirus 2} Probab=99.90 E-value=2.8e-28 Score=230.50 Aligned_cols=112 Identities=72% Similarity=0.855 Sum_probs=97.2 Template_Neff=2.500 Q sp|P0DTC2|SPIK 910 GVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEA 989 (1273) Q Consensus 910 gvtqnvlyenqklianqfnsaigkiqdslsstasalgklqdvvnqnaqalntlvkqlssnfgaissvlndilsrldkvea 989 (1273) |+|++||.||||+||+.||.|++.|++.++++++||.|+|||||++++||+.|++||+.|||||||.++||.+|||++|| T Consensus 1 gltt~VLq~NQk~iAnsFN~AignI~~gf~tts~AL~KIQdVVN~q~~aL~~Lt~QL~~NFgAISSSI~DIy~RLD~leA 80 (132) T 6LXT_F 1 GVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVES 80 (132) T ss_dssp ---CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC- T ss_pred CCchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhHHHHHHHHHHHHHHHHHc Confidence 68999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 990 EVQID-RLITGRLQSLQTYVTQQLIRAAEIRAS 1021 (1273) Q Consensus 990 evqid-rlitgrlqslqtyvtqqliraaeiras 1021 (1273) ..|+| |||||||.+|..||+|.+.+.++...- T Consensus 81 daQvD~RLItGRLaaLna~v~q~~~~~~~~~~~ 113 (132) T 6LXT_F 81 GGRGGPDVDLGDISGINASVVNIQKEIDRLNEV 113 (132) T ss_dssp ---------CCCCTTCCCCCCCCHHHHHHHHHH T ss_pred cccCCcchhcccHHHHHHHHHHHHHHHHHHHHH Confidence 99999 799999999999999999998887543 No 33 >6LXT_C 2019-nCoV S2 subunit; 2019-nCoV, HR1 and HR2 domain; HET: PG4; 2.9A {COVID-19 virus} Probab=99.90 E-value=2.8e-28 Score=230.50 Aligned_cols=112 Identities=72% Similarity=0.855 Sum_probs=100.9 Template_Neff=2.500 Q sp|P0DTC2|SPIK 910 GVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEA 989 (1273) Q Consensus 910 gvtqnvlyenqklianqfnsaigkiqdslsstasalgklqdvvnqnaqalntlvkqlssnfgaissvlndilsrldkvea 989 (1273) |+|++||.||||+||+.||.|++.|++.++++++||.|+|||||++++||+.|++||+.|||||||.++||.+|||++|| T Consensus 1 gltt~VLq~NQk~iAnsFN~AignI~~gf~tts~AL~KIQdVVN~q~~aL~~Lt~QL~~NFgAISSSI~DIy~RLD~leA 80 (132) T 6LXT_C 1 GVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVES 80 (132) T ss_dssp --CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC- T ss_pred CCchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhHHHHHHHHHHHHHHHHHc Confidence 68999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 990 EVQID-RLITGRLQSLQTYVTQQLIRAAEIRAS 1021 (1273) Q Consensus 990 evqid-rlitgrlqslqtyvtqqliraaeiras 1021 (1273) ..|+| |||||||.+|..||+|.+.+.++...- T Consensus 81 daQvD~RLItGRLaaLna~v~q~~~~~~~~~~~ 113 (132) T 6LXT_C 81 GGRGGPDVDLGDISGINASVVNIQKEIDRLNEV 113 (132) T ss_dssp ------CCCCCCCTTCCCCCCCCHHHHHHHHHH T ss_pred cccCCcchhcccHHHHHHHHHHHHHHHHHHHHH Confidence 99999 799999999999999999998887543 No 34 >6C6Z_A Spike protein, CDC2-C2 heavy chain; immune system, antibody, fusion glycoprotein; HET: NAG; 2.1A {Middle East respiratory syndrome-related coronavirus} Probab=99.85 E-value=6.9e-26 Score=228.84 Aligned_cols=148 Identities=22% Similarity=0.358 Sum_probs=108.8 Template_Neff=3.300 Q sp|P0DTC2|SPIK 319 RVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYAD 398 (1273) Q Consensus 319 rvqptesivrfpnitnlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptklndlcftnvyad 398 (1273) |+||...++|+++. ..|+|.++++ .++.++|.|.|+.++||..|+++|++...+++|+||||+|.||.++||..|++| T Consensus 1 rAqP~g~V~r~~~~-~~C~~~~~l~-~~~Psp~nWeR~~fsNCnfNlS~Lls~v~v~sF~C~gIsPskLa~mCfsSVtiD 78 (231) T 6C6Z_A 1 EAKPSGSVVEQAEG-VECDFSPLLS-GTPPQVYNFKRLVFTNCNYNLTKLLSLFSVNDFTCSQISPAAIASNCYSSLILD 78 (231) T ss_dssp ---------------CBCCCHHHHS-BCCCBGGGCEEEEECSSBCCHHHHHTTSEEEEEEEC-----------CCEEEEE T ss_pred CccceeEEEEecCC-CCCCchHHhc-CCCCCcceeEEEEEecCCccHHHHHhcceeeeeeecCCCHHHHhhhccceeeEE Confidence 68999999999999 9999999999 999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 399 SFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEI 472 (1273) Q Consensus 399 sfvirgdevrqiapgqtgkiadynyklpddftgcviawnsnnldskvggnynylyrlfrksnlkpferdistei 472 (1273) .|.|..++.++++||++|-|++||||+|+||+||+++|+-.+++..+.++.+|-|+..|. +|..|-++|. T Consensus 79 ~FaIp~s~~~~Lq~G~sG~i~~yNYKlp~~f~gC~l~y~~~~~~vnvt~p~~y~yia~r~----~~~~~~~~~~ 148 (231) T 6C6Z_A 79 YFSYPLSMKSDLSVSSAGPISQFNYKQSFSNPTCLILATVPHNLTTITKPLKYSYINKCS----RFLSDDRTEV 148 (231) T ss_dssp EEECCGGGGGGSSSSCCSHCCCCCCCCCSSSCEEEEEEECCTTCTTBCCCSEEEEEEEEE----EECTTSSCEE T ss_pred EEecChhhhhhccCCCCCchhhccccCCCCCCceEEEEEcCccccccCCCccceeeeeee----ccCCCCceEE Confidence 999999999999999999999999999999999999999777666555566666655544 3334445554 No 35 >5XGR_H Spike protein S1; MERS-CoV, BatCoV HKU5, CTD, evolution; HET: NAG; 2.1A {Bat coronavirus HKU5} Probab=99.85 E-value=9.7e-26 Score=224.72 Aligned_cols=181 Identities=21% Similarity=0.336 Sum_probs=148.3 Template_Neff=4.000 Q sp|P0DTC2|SPIK 335 LCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQ 414 (1273) Q Consensus 335 lcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptklndlcftnvyadsfvirgdevrqiapgq 414 (1273) .|+|.++++ .++.++|.|.|+.++||..|+++|++..++++|+||||+|.||.+.||..|++|.|.|..+..++++||+ T Consensus 2 ~C~~~~~l~-~~~Psp~nWeR~~fsNCnfNls~Lls~v~v~sF~C~~IspskLa~mCfsSvtiD~Faip~s~~~dLq~G~ 80 (204) T 5XGR_H 2 ECDFTPMLT-GTPPPIYNFKRLVFTNCNYNLTKLLSLFQVSEFSCHQVSPSSLATGCYSSLTVDYFAYSTDMSSYLQPGS 80 (204) T ss_dssp BCCCGGGGS-BCCCCGGGCEEEEECSEEECHHHHHTTSEEEEEEEESCCHHHHSSCCBSEEEEEEEECCGGGGGGGSTTC T ss_pred CCCChhHhc-CCCCCccceeEEEEecCCCCHHHHHhhceeeeeEeeCCCHHHhcccccceeEEEEEEecCccchhcCCCC Confidence 599999999 9999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 415 TGKIADYNYKLPDDFTGCVIAWNSNNLDSK--VGGNYNYLYRLFRKSN-----LKPFERDISTEIYQAGSTPCNGVEGFN 487 (1273) Q Consensus 415 tgkiadynyklpddftgcviawnsnnldsk--vggnynylyrlfrksn-----lkpferdisteiyqagstpcngvegfn 487 (1273) +|-|++||||+|++|+||+++|+-...+.. --++|+|+-|..+++. +.++++|++. |-... -+ T Consensus 81 sG~i~~yNYKld~s~~sC~l~~~~p~~~vnvt~ps~y~y~~~r~~~~~~~~~~~~~~~~~~cp---------c~~~~-~~ 150 (204) T 5XGR_H 81 AGAIVQFNYKQDFSNPTCRVLATVPQNLTTITKPSNYAYLTECYKTSAYGKNYLYNAPGAYTP---------CLSLA-SR 150 (204) T ss_dssp CSHHHHHTCCCCTTSCEEEEEEECCTTCCSBCCCSEEEEEEEEEEECSSSEEECCCCTTCCCT---------THHHH-TT T ss_pred CchhHhcccCCCCCCCccEEEEEcCchhcccCCccchheeeceeccccccccceeeCCCCccc---------ccccc-cC Confidence 999999999999999999999995543321 2567777777777665 5555555543 11000 23 Q sp|P0DTC2|SPIK 488 CYF---PLQS----YGFQ--PTNGVGYQPYRVVVLSFELLHAPATVCGPK 528 (1273) Q Consensus 488 cyf---plqs----ygfq--ptngvgyqpyrvvvlsfellhapatvcgpk 528 (1273) |+- |+.. +++| ...|+|+| +++|++++....+-|||.-. T Consensus 151 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~--g~~Vis~k~g~~~~~~~~~~ 198 (204) T 5XGR_H 151 GFSTKYQSHSDGELTTTGYIYPVTGNLQ--MAFIISVQYGTDTNSVCPMQ 198 (204) T ss_dssp CCSSTTCEEECSSEEEEEEEEECCSSCE--EEEEEEEECCSCTTSEEECC T ss_pred CcccCccccCCCcccccCeEeeecCccc--EEEEEEEEeCCCCCcccccc Confidence 333 3222 4453 24588888 99999999999999999643 No 36 >4QZV_B Dipeptidyl peptidase 4 (E.C.3.4.14.5), Spike; 8-BLADED BETA-PROPELLER DOMAIN, ALPHA/BETA HYDROLASE; HET: NAG, BMA; 2.592A {Homo sapiens} Probab=99.83 E-value=4.1e-25 Score=224.70 Aligned_cols=137 Identities=24% Similarity=0.439 Sum_probs=111.3 Template_Neff=3.300 Q sp|P0DTC2|SPIK 319 RVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYAD 398 (1273) Q Consensus 319 rvqptesivrfpnitnlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptklndlcftnvyad 398 (1273) .+||...++|+++. ..|+|.++|+ .++.++|.|.|+.++||..|+++|++...+++|+||||||.||.++||..|++| T Consensus 1 ~AqP~g~V~r~~~~-~~C~~~~~l~-~~~Psp~nWeR~~fsNCnfN~S~Lls~v~v~sF~C~gIsPskLa~mCfsSVtiD 78 (246) T 4QZV_B 1 EASATGTFIEQPNA-TECDFSPMLT-GVAPQVYNFKRLVFSNCNYNLTKLLSLFAVDEFSCNGISPDSIARGCYSTLTVD 78 (246) T ss_dssp ---------------CBCCCCTTTS-SCCCCGGGCEEEEECSCBBCHHHHHTTEEEEEEEEESSCTTGGGTCCBSEEEEE T ss_pred CceeeeEEEEcCCC-CCCCChHHhc-CCCCCcceeEEEEEecCCCcHHHHHhhceeeeeEecCCCHHHHcccccceeeEE Confidence 37899999999999 9999999999 999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 399 SFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKV--GGNYNYLYRLFRK 458 (1273) Q Consensus 399 sfvirgdevrqiapgqtgkiadynyklpddftgcviawnsnnldskv--ggnynylyrlfrk 458 (1273) .|.|..+..++++||++|-|++||||||+||+||+++|+-.+ +..+ -++|+|+.|..++ T Consensus 79 ~FaIp~s~~~~Lq~G~sG~i~~yNYKlp~~f~gC~l~y~~~~-nvn~t~p~~y~yia~r~~~ 139 (246) T 4QZV_B 79 YFAYPLSMKSYIRPGSAGNIPLYNYKQSFANPTCRVMASVLA-NVTITKPHAYGYISKCSRL 139 (246) T ss_dssp EEECCGGGGGGGSTTCCCHCCCCCCCCCCSSCEEEEEEEECT-TSCCCCCSEEEEEEEEEEE T ss_pred EEEcchhhhhhcCCCCCCchhhccccCCCCCCceEEEEEecc-ccccCCcccceeeeeeecC Confidence 999999999999999999999999999999999999999555 2222 3455555554433 No 37 >4L3N_B S protein; beta-sheet fold, VIRAL PROTEIN; HET: NAG; 2.13A {Human betacoronavirus 2c Jordan-N3/2012} Probab=99.81 E-value=2.3e-24 Score=216.33 Aligned_cols=124 Identities=20% Similarity=0.356 Sum_probs=116.1 Template_Neff=3.200 Q sp|P0DTC2|SPIK 334 NLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPG 413 (1273) Q Consensus 334 nlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptklndlcftnvyadsfvirgdevrqiapg 413 (1273) ..|+|.++++ .++.++|.|.|+.++||..|+++|++...+++|+||||||+||.++||..|++|.|.|..+++++++|| T Consensus 3 ~~C~~~~~l~-~~~PsP~nWeR~~fsNCnfNlS~Lls~v~v~sF~C~gIsPskLa~mCfsSVtiD~FaIp~s~~~~Lq~G 81 (216) T 4L3N_B 3 VECDFSPLLS-GTPPQVYNFKRLVFTNCNYNLTKLLSLFSVNDFTCSQISPAAIASNCYSSLILDYFSYPLSMKSDLSVS 81 (216) T ss_dssp CBCCCGGGGS-BCCCCGGGCEEEEECSEEECHHHHHHTSEEEEEEEESSCHHHHTTCCBSEEEEEEEECCGGGHHHHHTG T ss_pred CCCCchHHhc-CCCCCcceeEEEEEecCCccHHHHHhcceeeeeeecCCCHHHHhhhccceeeEEEEecChhhhhhccCC Confidence 5799999999 999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 414 QTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRK 458 (1273) Q Consensus 414 qtgkiadynyklpddftgcviawnsnnldskvggnynylyrlfrk 458 (1273) ++|-|++||||+|+||+||+++|+-.+++..+.++.+|-|+..|. T Consensus 82 ssG~i~~yNYKlp~df~gC~l~y~~~~~~vnvt~p~~y~yia~r~ 126 (216) T 4L3N_B 82 SAGPISQFNYKQSFSNPTCLILATVPHNLTTITKPLKYSYINKCS 126 (216) T ss_dssp GGSHCCCCCCCCCSSSCEEEEEEECCTTCCSBCCCSEEEEEEEEE T ss_pred CCCchhhccccCCCCCCccEEEEEcCccccccCCCcccceeeeee Confidence 999999999999999999999999877766666677777666555 No 38 >5YY5_B MERS-CoV RBD, Heavy chain, Light; MERS-CoV, spike glycorptotein, neutralizing antibody; HET: NAG; 2.8A {Middle East respiratory syndrome coronavirus} Probab=99.81 E-value=3.5e-24 Score=214.39 Aligned_cols=124 Identities=20% Similarity=0.356 Sum_probs=115.2 Template_Neff=3.300 Q sp|P0DTC2|SPIK 334 NLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPG 413 (1273) Q Consensus 334 nlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptklndlcftnvyadsfvirgdevrqiapg 413 (1273) ..|+|.++++ .++.++|.|.|+.++||..|+++|++...+++|+||||+|.||.++||..|++|.|.|..+++++++|| T Consensus 2 ~~C~~~~~l~-~~~Psp~nWeR~~fsNCnfNlS~Lls~v~v~sF~C~gIsPskLa~mCfsSVtiD~FaIp~s~~~~Lq~G 80 (209) T 5YY5_B 2 VECDFSPLLS-GTPPQVYNFKRLVFTNCNYNLTKLLSLFSVNDFTCSQISPAAIASNCYSSLILDYFSYPLSMKSDLSVS 80 (209) T ss_dssp CBCCCGGGGS-BCCCBGGGCEEEEECSEEECHHHHHHTSEEEEEEEESSCHHHHTTCCBSEEEEEEEECCGGGGGGSSTT T ss_pred CCCCchHHhc-CCCCCcceeEEEEEecCCccHHHHHhcceeeeeeecCCCHHHHhhhccceeeEEEEecChhhhhhccCC Confidence 4799999999 999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 414 QTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRK 458 (1273) Q Consensus 414 qtgkiadynyklpddftgcviawnsnnldskvggnynylyrlfrk 458 (1273) ++|-|++||||+|+||+||+++|+-.+++..+.++.+|-|+..|. T Consensus 81 ~sG~i~~yNYKlp~~f~gC~l~y~~~~~~vnvt~p~~y~yia~r~ 125 (209) T 5YY5_B 81 SAGPISQFNYKQSFSNPTCLILATVPHNLTTITKPLKYSYINKCS 125 (209) T ss_dssp CCSHCCCCCCCCCSSSCEEEEEEECCTTCTTBCCCSCEEEEEEEE T ss_pred CCCchhhccccCCCCCCccEEEEEcCccccccCCCcccceeeeee Confidence 999999999999999999999999777666655666666665554 No 39 >4L72_B Dipeptidyl peptidase 4 (E.C.3.4.14.5), MERS-CoV; alpha/beta hydrolase beta-propeller, Glycolation, virus; HET: BMA, NAG; 3.005A {Homo sapiens} Probab=99.81 E-value=4e-24 Score=213.42 Aligned_cols=123 Identities=20% Similarity=0.365 Sum_probs=115.1 Template_Neff=3.300 Q sp|P0DTC2|SPIK 335 LCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQ 414 (1273) Q Consensus 335 lcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptklndlcftnvyadsfvirgdevrqiapgq 414 (1273) .|+|.++++ .++.++|.|.|+.++||..|+++|++...+++|+||||+|+||.++||..|++|.|.|..+++++++||+ T Consensus 1 ~C~~~~~~~-~~~Psp~nWeR~~fsNCnfNlS~Lls~v~v~sF~C~gIsPskLa~mCfsSVtiD~FaIp~s~~~~Lq~G~ 79 (204) T 4L72_B 1 ECDFSPLLS-GTPPQVYNFKRLVFTNCNYNLTKLLSLFSVNDFTCSQISPAAIASNCYSSLILDYFSYPLSMKSDLSVSS 79 (204) T ss_pred CCChhHHhh-cCCCCcceeEEEEEecCCCCHHHHHhhceeeeeEeeCCCHHHHcccccCeeeEEEEeccccchhhcCCCC Confidence 489999999 9999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 415 TGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRK 458 (1273) Q Consensus 415 tgkiadynyklpddftgcviawnsnnldskvggnynylyrlfrk 458 (1273) +|-|++||||+|+||+||+++|+-.+++..+.++.+|-|+..|. T Consensus 80 sG~i~~yNYKlp~~f~gC~l~y~~~~~~vnvt~p~~y~yia~r~ 123 (204) T 4L72_B 80 AGPISQFNYKQSFSNPTCLILATVPHNLTTITKPLKYSYINKCS 123 (204) T ss_pred CchHHhccccCCCCCCceEEEEEcCcccccCCCccccceeeeec Confidence 99999999999999999999999877666666677777666555 No 40 >3R4D_D CEA-related cell adhesion molecule 1; immunoglobulin, beta-sandwich, mCEACAM1a - immunoglobulin; HET: NAG; 3.1A {Mus musculus} Probab=99.80 E-value=5.2e-24 Score=219.92 Aligned_cols=240 Identities=20% Similarity=0.268 Sum_probs=141.9 Template_Neff=4.700 Q sp|P0DTC2|SPIK 30 NSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNG---TKRFDNPVLPFNDGVYFASTEKSNI------ 100 (1273) Q Consensus 30 nsftrgvyypdkvfrssvlhstqdlflpffsnvtwfhaihvsgtng---tkrfdnpvlpfndgvyfasteksni------ 100 (1273) -|-.+|+||||..++|++.+-.|+||.++-++.+-.-. +|++- --.+++++.||+||+++...+++|. T Consensus 30 vs~~~G~yYp~~rvysN~t~L~qglfp~~gs~~~~y~~---t~~~~~~~~~~y~~~~~~F~dGifv~v~~~~n~~~~~~~ 106 (288) T 3R4D_D 30 VSQGLGTYYVLDRVYLNATLLLTGYYPVDGSKFRNLAL---TGTNSVSLSWFQPPYLSQFNDGIFAKVQNLKTSTPSGAT 106 (288) T ss_dssp ---------------------CEEECCCTTCCCEECCC---EESSEEEGGGSSTTTSEECTTEEEEEEECGGGGSCTTCC T ss_pred eecCeEEEEeCCeEEeceeeeecccccCCCCceEEEEe---ecCCCCccceecCCcchhcCCeEEEEeeecccCCCCccc Confidence 45578999999999999999999999999988875422 34332 2467888999999999999998875 Q sp|P0DTC2|SPIK 101 --IRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVYYHKNNKSWMESEFRVYSSANNCTFEYVSQPFLMD 178 (1273) Q Consensus 101 --irgwifgttldsktqsllivnnatnvvikvcefqfcndpflgvyyhknnkswmesefrvyssannctfeyvsqpflmd 178 (1273) -..++||+|.+..+++++|+++-+...|.+|.|+.|..|.+.++..-+|.+.. +++. ..+.||+|.+. +.|-+| T Consensus 107 ~~ypa~~fGstf~n~s~tvvI~P~~~~~~it~C~~~vC~~p~~~~~p~~g~~~~~--~~~~-~~~~~c~~~~~-~nfT~d 182 (288) T 3R4D_D 107 AYFPTIVIGSLFGYTSYTVVIEPYNGVIMASVCQYTICQLPYTDCKPNTNGNKLI--GFWH-TDVKPPICVLK-RNFTLN 182 (288) T ss_dssp CCSCCEEEESSCSSSSEEEEEEEETTEEEEEEEECCBBSSCCEESSCCCTTCTTC--CSSB-CCSSCCCEEEE-EEEECC T ss_pred eecceEEEecccCCcceEEEEeCCCceEEEEEEEEEEcCCCeeEEccCCCCCcee--eeee-ecCCCCEEEEe-eeeccC Confidence 46788999999999999999999999999999999999999888744332222 3445 67889999764 445444 Q sp|P0DTC2|SPIK 179 LEGKQGNFKNLREFVFKNIDGYFKIYSKHTPINL---VRDLPQGFSALEPLVDLPIGINITRFQTLLALHRSYLTPGDSS 255 (1273) Q Consensus 179 legkqgnfknlrefvfknidgyfkiyskhtpinl---vrdlpqgfsaleplvdlpiginitrfqtllalhrsyltpgdss 255 (1273) ...+ .|. |+|++.||.|-+|-.+...+. .+.+| |+..+.+. .+-|+..++ + T Consensus 183 ~~~~--~~~----f~F~~~~G~f~~Y~~~~~~~~~f~f~~~~-g~~~~~yy----------------vip~~~~~~---~ 236 (288) T 3R4D_D 183 VNAD--AFY----FHFYQHGGTFYAYYADKPSATTFLFSVYI-GDILTQYY----------------VLPFICNPT---A 236 (288) T ss_dssp TTCS--EEE----EEEEEETTEEEEEEESSSSCCEEEEEEEC-SSCCCEEE----------------ECCEECCCS---S T ss_pred cChh--eee----EEEEEcCCEEEEEEECCCCCceeeeccee-ccccceeE----------------EeeeeecCC---C Confidence 3321 122 999999999988877766553 55555 66555555 334444444 4 Q sp|P0DTC2|SPIK 256 SGWTAGAAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLK 304 (1273) Q Consensus 256 sgwtagaaayyvgylqprtfllkynengtitdavdcaldplsetkctlk 304 (1273) ++| ..++|||++|.+|+|||+|++||.|++||||+-|+++|-||... T Consensus 237 ~~~--~~~~~yV~~L~~r~yLl~Fd~nG~It~AvDCa~~~~sEL~~~~~ 283 (288) T 3R4D_D 237 GST--FAPRYWVTPLVKRQYLFNFNQKGVITSAVDCASSYTSEIKCKTH 283 (288) T ss_dssp CSC--CCCCEEEEECCEEEC----------------------------- T ss_pred CCc--cccEEEEEeceeeeEEEeecCCCeEeEEEEcccCcccccccccC Confidence 455 78899999999999999999999999999999999999999743 No 41 >4NJL_A S protein; six-helix-bundle, coronavirus, MERS-Cov, fusion inhibitor; HET: PGE; 2.3A {Middle East respiratory syndrome coronavirus} Probab=99.79 E-value=1.2e-23 Score=199.38 Aligned_cols=122 Identities=42% Similarity=0.571 Sum_probs=111.0 Template_Neff=2.500 Q sp|P0DTC2|SPIK 910 GVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEA 989 (1273) Q Consensus 910 gvtqnvlyenqklianqfnsaigkiqdslsstasalgklqdvvnqnaqalntlvkqlssnfgaissvlndilsrldkvea 989 (1273) |+||+||.||||+||+.||.|+|.|++.+.++++||.|+|||||++++||+.|+.||+.|||||||.++||.+|||++|| T Consensus 2 gltq~VLq~NQk~iA~sFN~AignIq~gf~tts~AL~KIQdVVN~q~~aL~~Lt~QL~nNFgAISSSIqdIy~RLD~LeA 81 (131) T 4NJL_A 2 GITQQVLSENQKLIANKFNQALGAMQTGFTTTNEAFQKVQDAVNNNAQALSKLASELSNTFGAISASIGDIIQRLDVLEQ 81 (131) T ss_dssp -CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC T ss_pred CcchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhHHHHHHHHHHHHHHHHHh Confidence 78999999999999999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 990 EVQIDRLI--TGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLG 1035 (1273) Q Consensus 990 evqidrli--tgrlqslqtyvtqqliraaeirasanlaatkmsecvlg 1035 (1273) .+|++|+| .||++-+.+ +|....-+..|+.-+..|..||... T Consensus 82 Daqrl~~l~~~~~~~~~n~----~l~d~t~~~~s~~q~~~~~ne~~~~ 125 (131) T 4NJL_A 82 SGGRGGSIPNFGSLTQINT----TLLDLTYEMLSLQQVVKALNESYID 125 (131) T ss_dssp SSSCSCCCCCCCCCCCCCC----CCCCCHHHHHHHHHHHHHHHTTCCC T ss_pred HhcccchhhhhhhHHHHhH----hHHHHHHHHhhHHHHHHHHHHhccc Confidence 99999988 888776665 6666666777887788888888653 No 42 >6QFY_A Spike glycoprotein; sialic acid binding, beta-sandwich, viral; HET: NAG, BMA; 2.97A {Porcine hemagglutinating encephalomyelitis virus} Probab=99.78 E-value=2.6e-23 Score=214.69 Aligned_cols=236 Identities=20% Similarity=0.276 Sum_probs=176.2 Template_Neff=4.800 Q sp|P0DTC2|SPIK 30 NSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNG---TKRFDNPVLPFNDGVYFASTEKSNII----- 101 (1273) Q Consensus 30 nsftrgvyypdkvfrssvlhstqdlflpffsnvtwfhaihvsgtng---tkrfdnpvlpfndgvyfasteksnii----- 101 (1273) -|-.+|+||||..++|+..+-.|+||.++-++.+-.-. +|++- --.+++++.||+||+++...+++|.- T Consensus 29 vs~~~G~yYp~~r~ysN~t~L~qglfp~~gs~~~~y~~---t~~~~~~~~~~y~~~~~~F~dGifv~v~~~~n~~~~~~~ 105 (288) T 6QFY_A 29 VTNGLGTFYVLDRVYLNTTLLLNGYYPISGATFRNMAL---KGTRLLSTLWFKSPFLSPFNDGIFAKVKNSRFSKDGVIY 105 (288) T ss_dssp CTTSTTCBCCTTCCCCSEEEEEEEEEECTTCEEEECCC---EESSCEEGGGGSTTTSEECSSEEEEEEECBCCEETTEEC T ss_pred cccCceeEecCCceeccceeeeeceecCCCCCceeeee---ecCCCCCcceecCCCcccccCcEEEEeEEeecCCCCCce Confidence 45568999999999999999999999999888875422 33332 34678889999999999999988863 Q sp|P0DTC2|SPIK 102 ---RGWIFGTTLDSKTQSLLIVNNATNV-----V---IKVCEFQFCNDPFLGVYYHKNNKSWMESEFRVYSSANNCTFEY 170 (1273) Q Consensus 102 ---rgwifgttldsktqsllivnnatnv-----v---ikvcefqfcndpflgvyyhknnkswmesefrvyssannctfey 170 (1273) -.++||+|.+..+++++|+++-+++ . |.+|.|+.|..|...++..-.| + --+++. ..+.+|+|.+ T Consensus 106 ~~yp~~~fGstf~n~s~tvvI~P~~~g~~~~~~~~~~it~C~~~vC~~p~~~~~p~~g~-~--~~~~~~-~~~~~c~~~~ 181 (288) T 6QFY_A 106 SEFPAITIGSTFVNSSHSIVVKPHTSFINGNLQGLLQISVCQYTMCEYPHTICHPNLGN-Q--RIELWH-YDTDVVSCLY 181 (288) T ss_dssp CBCCCEEEESSCSTTSCEEEEEEEE----EEEEEEEEEEEECCCEEEEEEEECCGGGCC-S--SCCEEE-CC----CSEE T ss_pred eecCceeeeccccCCceEEEEcCCCCCeeccccccceeeeeeEEecCCCeeEEcCCCCC-c--cceeeE-EecCCceEEE Confidence 3677999999999999999998864 3 6799999999999988874443 3 234555 7789999976 Q sp|P0DTC2|SPIK 171 VSQPFLMDLEGKQGNFKNLREFVFKNIDGYFKIYSKHTPINL---VRDLPQGFSALEPLVDLPIGINITRFQTLLALHRS 247 (1273) Q Consensus 171 vsqpflmdlegkqgnfknlrefvfknidgyfkiyskhtpinl---vrdlpqgfsaleplvdlpiginitrfqtllalhrs 247 (1273) . +.|-+|...+ .|. |+|++.||.|-+|-.+...+. .+.+| |+..+.+. -+|..++ T Consensus 182 ~-~nfT~d~~~~--~~~----f~F~~~~G~f~~Y~~~~~~~~~f~f~~~~-~~~~~~yy-vip~~~~------------- 239 (288) T 6QFY_A 182 K-RNFTYDVNAD--YLY----FHFYQEGGTFYAYFTDTGFVTKFLFKLYL-GTVLSHYY-VMPLTCD------------- 239 (288) T ss_dssp E-ECCBCCTTCS--EEE----EEEEEETTEEEEEEESSSSSBEEEEEEEC-SSCCCEEE-ECCEECS------------- T ss_pred e-eeeccccccc--eEE----EEEEEcCCeEEEEEeccCCcceeeecCCc-ccccceeE-EceecCC------------- Confidence 4 4554444332 222 999999999988877766553 55566 66666665 2232222 Q sp|P0DTC2|SPIK 248 YLTPGDSSSGWTAGAAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKS 305 (1273) Q Consensus 248 yltpgdsssgwtagaaayyvgylqprtfllkynengtitdavdcaldplsetkctlks 305 (1273) ++ ..++|||++|.+|+|||+|++||.|++||||+-|+++|-||..+| T Consensus 240 --~~---------~~~~~yV~~L~~~~yLl~Fd~nG~It~AvDCa~~~~sEL~Cst~S 286 (288) T 6QFY_A 240 --SA---------LSLEYWVTPLTTRQFLLAFDQDGVLYHAVDCASDFMSEIMCKTSS 286 (288) T ss_dssp --S-------------CEEEEEEEEEEEEEEECTTCCEEEEEETTSCHHHHHHHHCCS T ss_pred --Cc---------cceeEEEEEcceeeEEEeecCCCeEeeEEEcccCcchhhccccCC Confidence 22 668999999999999999999999999999999999999998776 No 43 >4H14_A Spike glycoprotein; beta-sandwich, sugar binding, VIRAL PROTEIN; HET: NAG; 1.55A {Bovine coronavirus} Probab=99.78 E-value=3.5e-23 Score=214.01 Aligned_cols=235 Identities=21% Similarity=0.266 Sum_probs=184.1 Template_Neff=4.700 Q sp|P0DTC2|SPIK 30 NSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNG---TKRFDNPVLPFNDGVYFASTEKSNI------ 100 (1273) Q Consensus 30 nsftrgvyypdkvfrssvlhstqdlflpffsnvtwfhaihvsgtng---tkrfdnpvlpfndgvyfasteksni------ 100 (1273) -|-.+|+||||..++|+..+-.|+||.++-++.+-.-. +|++- --.+++++.||+||+++...+++|. T Consensus 29 vs~~~G~yYp~~rvysN~t~L~qglfp~~gs~~~~y~~---t~~~~~~~~~~y~~~~~~F~dGifv~v~~~~n~~~~~~~ 105 (290) T 4H14_A 29 VTNGLGTYYVLDRVYLNTTLLLNGYYPTSGSTYRNMAL---KGTLLLSRLWFKPPFLSDFINGIFAKVKNTKVIKKGVMY 105 (290) T ss_dssp CTTSTTCBCCTTCCCCSEEEEEEEEECCTTCCCEECCC---EESSCEEGGGGSTTTSEECSSEEEEEEECEEEEETTEEE T ss_pred cccCeeEEEeCCeEEeeeeeeecceecCCCCceeeeee---eeccccccccccCCccccccCcEEEEEEeecccCCCcee Confidence 45578999999999999999999999999988875422 34332 2467888999999999999998875 Q sp|P0DTC2|SPIK 101 --IRGWIFGTTLDSKTQSLLIVNNATNV-----V---IKVCEFQFCNDPFLGVYYHKNNKSWMESEFRVYSSANNCTFEY 170 (1273) Q Consensus 101 --irgwifgttldsktqsllivnnatnv-----v---ikvcefqfcndpflgvyyhknnkswmesefrvyssannctfey 170 (1273) -..++||+|.+..+++++|+++-+++ . |.+|.|+.|..|.+.++..-.| + --+++. ..+.||+|.| T Consensus 106 ~~ypa~~fGstf~n~s~tvvI~P~~~g~~~~~~~~~~it~C~~~vC~~p~~~~~p~~g~-~--~~~~~~-~~~~~c~~~~ 181 (290) T 4H14_A 106 SEFPAITIGSTFVNTSYSVVVQPHTTNLDNKLQGLLEISVCQYTMCEYPHTICHPKLGN-K--RVELWH-WDTGVVSCLY 181 (290) T ss_dssp EECCCEEEESSCSTTSCEEEEEEEEEESSSSEEEEEEEEEECCCEEEEEEEECCGGGCC-S--SCCEEE-CCCSCCCEEE T ss_pred eecCeeEEeccccCCeeEEEEcCCCCCccchhcceeEeeeeeEEecCCCeEEEeccCCC-c--eeeeeE-EecCCceEEE Confidence 46788999999999999999998864 3 6799999999999988874443 3 234455 7789999976 Q sp|P0DTC2|SPIK 171 VSQPFLMDLEGKQGNFKNLREFVFKNIDGYFKIYSKHTPINL---VRDLPQGFSALEPLVDLPIGINITRFQTLLALHRS 247 (1273) Q Consensus 171 vsqpflmdlegkqgnfknlrefvfknidgyfkiyskhtpinl---vrdlpqgfsaleplvdlpiginitrfqtllalhrs 247 (1273) . +.|-+|...+ .|. |+|++.||.|-+|-.+...+. .+.+| |+..+.+. -+|..++. T Consensus 182 ~-~nfT~d~~~~--~~~----f~F~~~~G~f~~Y~~~~~~~~~f~f~~~~-~~~~~~yy-vip~~~~~------------ 240 (290) T 4H14_A 182 K-RNFTYDVNAD--YLY----FHFYQEGGTFYAYFTDTGVVTKFLFNVYL-GTVLSHYY-VLPLTCSS------------ 240 (290) T ss_dssp E-EEEECCTTCS--EEE----EEEEEETTEEEEEEESSSSSBEEEEEEEC-SSCCCEEE-ECCEECSS------------ T ss_pred e-eeeccccccc--eee----EEEEEeCCeEEEEEEccCcccceEeccee-eeecceeE-EceeecCC------------ Confidence 4 4554544332 222 999999999988877766553 55566 66666665 23333332 Q sp|P0DTC2|SPIK 248 YLTPGDSSSGWTAGAAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLK 304 (1273) Q Consensus 248 yltpgdsssgwtagaaayyvgylqprtfllkynengtitdavdcaldplsetkctlk 304 (1273) + ..++|||++|.+|+|||+|++||.|++||||+-|+++|-||... T Consensus 241 ---~---------~~~~~yV~~L~~r~yLl~Fd~nG~It~AvDCa~~~~sEL~c~~~ 285 (290) T 4H14_A 241 ---A---------MTLEYWVTPLTSKQYLLAFNQDGVIFNAVDCKSDFMSEIKCKTH 285 (290) T ss_dssp ---C---------CCCCEEEEEEEEEEEEEEECTTSCEEEEEETTSSHHHHHHHHSC T ss_pred ---c---------cceeEEEEeceeeeEEEEecCCCeEeEEEecccCcchhhhcccC Confidence 1 66899999999999999999999999999999999999999753 No 44 >4MOD_B HR1 of S protein, LINKER; MERS-CoV, Viral envelope proteins, Spike; 1.901A {Human betacoronavirus 2c EMC/2012} Probab=99.75 E-value=1.9e-22 Score=191.27 Aligned_cols=118 Identities=35% Similarity=0.489 Sum_probs=66.4 Template_Neff=3.100 Q sp|P0DTC2|SPIK 918 ENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKV--EAEVQIDR 995 (1273) Q Consensus 918 enqklianqfnsaigkiqdslsstasalgklqdvvnqnaqalntlvkqlssnfgaissvlndilsrldkv--eaevqidr 995 (1273) ||||+||+.||.|+|.|++.+.++++||.|+|||||+++++|+.|.+||..|||+|||.++||..|||++ ||.+|+|| T Consensus 2 ~NQk~iA~sFN~A~~~i~~~~~t~~~Al~kiQ~VVN~q~~aL~~l~~EL~knFkAISSsI~dIy~rld~~~~~ad~qvdr 81 (129) T 4MOD_B 2 ENQKLIANKFNQALGAMQTGFTTTNEAFQKVQDAVNNNAQALSKLASELSNTFGAISASIGDILVPRGSGGSGGSGGLEV 81 (129) T ss_dssp -CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC-------------------------------- T ss_pred hHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhCcchhhHHHhhhccCCCCCCccccchh Confidence 7999999999999999999999999999999999999999999999999999999999999999999997 89999999 Q sp|P0DTC2|SPIK 996 LITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKR 1039 (1273) Q Consensus 996 litgrlqslqtyvtqqliraaeirasanlaatkmsecvlgqskr 1039 (1273) ||+|||.+|.++++.--...++++ -...+.-||+..+.+- T Consensus 82 LitgrL~~LNa~~~dl~~em~~l~----~vvk~LNes~idlkel 121 (129) T 4MOD_B 82 LFQGPLTQINTTLLDLTYEMLSLQ----QVVKALNESYIDLKEL 121 (129) T ss_dssp -------CCCCCCCCCHHHHHHHH----HHHHHHHTTCCC---- T ss_pred hcCCChHHHHHHHHHHHHHHHHHH----HHHHHHHHHhhcHHHH Confidence 999999999999876544333333 3667788888766543 No 45 >5X4R_A S protein; MERS-CoV, spike, N-terminal domain, VIRAL; HET: NAG; 1.5A {Middle East respiratory syndrome coronavirus} Probab=99.71 E-value=2.2e-21 Score=204.51 Aligned_cols=263 Identities=21% Similarity=0.314 Sum_probs=191.1 Template_Neff=4.200 Q sp|P0DTC2|SPIK 14 QCVNL-TTRTQLPPAYT----NSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNG--T-------KRF 79 (1273) Q Consensus 14 qcvnl-ttrtqlppayt----nsftrgvyypdkvfrssvlhstqdlflpffsnvtwfhaihvsgtng--t-------krf 79 (1273) .|... ....-+++.++ -+-.+|+||||..++++..+-.|+||.+.-++.+-.- ++|++. + -.+ T Consensus 12 ~C~~~~~~~~~~~~~~~~~idvs~~~G~yYp~~rvysN~tlL~qglfp~~gs~~~~y~---~~~~~~~~~~~~~~~~~~y 88 (342) T 5X4R_A 12 ACIEVDIQQTFFDKTWPRPIDVSKADGIIYPQGRTYSNITITYQGLFPYQGDHGDMYV---YSAGHATGTTPQKLFVANY 88 (342) T ss_dssp BCCCEEECGGGGCCCCCCCCCGGGTTTCBCCTTSCCCSEEEEEEEEECCTTCCCEEEC---CEECCBCSSCBCSEEECSG T ss_pred ceEEeccCccccCCCCCcceecccCceeEeeCCeeEeeeeeeeeccccCCCCcceEEE---EEecCCCCCCCcceeeecC Confidence 36665 23333444555 3446899999999999999999999999988887543 333333 2 356 Q sp|P0DTC2|SPIK 80 DNPVLPFNDGVYFASTEKSNIIRG-----------------WIFGTTLDSKT---Q------SLLIVNNATNVVI----- 128 (1273) Q Consensus 80 dnpvlpfndgvyfasteksniirg-----------------wifgttldskt---q------sllivnnatnvvi----- 128 (1273) +.+..||+||+++...+++|.-.+ ++||+|.+... + +++|+++-++.++ T Consensus 89 ~~~~~~F~dGifvkv~~~~n~t~~~~~~~~~~~~~~~~ypa~~fGstF~N~s~~~~~~~~~~tlvI~P~~~g~~~~~~~c 168 (342) T 5X4R_A 89 SQDVKQFANGFVVRIGAAANSTGTVIISPSTSATIRKIYPAFMLGSSVGNFSDGKMGRFFNHTLVLLPDGCGTLLRAFYC 168 (342) T ss_dssp GGCCEECTTCEEEEESTTTTSEEECSSSTTCEEEEECCCCCEEEESCEEECTTSCEEEECSEEEEEEEETTTTEEEEEEE T ss_pred CCChhhccCeEEEEEeeeeccCCCeeecCccccchhhcccceEEecccccCCCccceeecceEEEEecCCCCceeeeEee Confidence 788999999999998887776443 57999999777 6 8999999888765 Q sp|P0DTC2|SPIK 129 --KVCEFQFCNDPFLGVYYHKNN---KSWMES---------EFRVYSSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVF 194 (1273) Q Consensus 129 --kvcefqfcndpflgvyyhknn---kswmes---------efrvyssannctfeyvsqpflmdlegkqgnfknlrefvf 194 (1273) ..++..-|..|..-+++--+. -+|+.+ +++.|..+.||+|.+. +.|-+|. +.+.|. |.| T Consensus 169 ~~~prtit~C~~p~~~~~p~~~~~~~~~~~~~~~~~~~~~~~~~~f~~~~nc~f~~~-~nfT~d~--~~~wf~----~~F 241 (342) T 5X4R_A 169 ILEPRSGNHCPAGNSYTSFATYHTPATDCSDGNYNRNASLNSFKEYFNLRNCTFMYT-YNITEDE--ILEWFG----ITQ 241 (342) T ss_dssp EEEECCSBTSTTSTTCCCCCEEECHHHHSCTTCCCTTHHHHHHHHHEEEEEEEEEEE-EECCCCC--CCEEEE----EEE T ss_pred eeccCccccCCCCCeEeeeeecCCCCccCCCccccccccccchhhhcccCCcEEEEe-eecCcch--hhheEE----EEE Confidence 333344566666655542221 345444 6778899999999875 3444443 333444 999 Q sp|P0DTC2|SPIK 195 KNID-GYFKIYSKHTPINL---VRDLPQGFSALEPLVDLPIGINITRFQTLLALHRSYLTPGDSSSGWTAGAAAYYVGYL 270 (1273) Q Consensus 195 knid-gyfkiyskhtpinl---vrdlpqgfsaleplvdlpiginitrfqtllalhrsyltpgdsssgwtagaaayyvgyl 270 (1273) ++.| |.|-+|-.++..+. ...+| |...|.+..-+|..++ ++ .+.|. ..++|||++| T Consensus 242 ~~~~~G~f~~Y~~d~~~~~~f~f~~~p-g~~~l~yy~viprs~~---------------~~---~~~~~-~~~ayyV~~L 301 (342) T 5X4R_A 242 TAQGVHLFSSRYVDLYGGNMFQFATLP-VYDTIKYYSIIPHSIR---------------SI---QSDRK-AWAAFYVYKL 301 (342) T ss_dssp ETTEEEEEESTTTCTTTCCBEEEEEEC-CCSCCCEEEECCEEEC---------------CC---GGGCC-EECCEEEEEC T ss_pred EeCCceeEEEEEEecCCCcceeccccc-cccccceeEeeeeeec---------------CC---cccce-eEEEEEEEEc Confidence 9999 99999988776653 55566 7777777664554443 22 45566 7899999999 Q sp|P0DTC2|SPIK 271 QPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSF 306 (1273) Q Consensus 271 qprtfllkynengtitdavdcaldplsetkctlksf 306 (1273) .+|+|||.||+||.|++||||+-|+++|-||..+|- T Consensus 302 ~~r~yLl~Fd~nG~It~AvDCa~d~~sELkCs~~~~ 337 (342) T 5X4R_A 302 QPLTFLLDFSVDGYIRRAIDCGFNDLSQLHCSYESH 337 (342) T ss_dssp EEEEEEEEECTTSCEEEEEEGGGCHHHHHHHC---- T ss_pred ceeeEEEeccCCCeEEEEEecCCCcchhhcceecCC Confidence 999999999999999999999999999999998875 No 46 >6J11_C Spike glycoprotein, VH of 7D10; MERS-CoV, Antibody, VIRAL PROTEIN; HET: MAN, NAG, BMA; 3.0A {Middle East respiratory syndrome-related coronavirus} Probab=99.70 E-value=2.8e-21 Score=203.44 Aligned_cols=262 Identities=21% Similarity=0.313 Sum_probs=192.3 Template_Neff=4.300 Q sp|P0DTC2|SPIK 14 QCVNL-TTRTQLPPAYT----NSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNG--T-------KRF 79 (1273) Q Consensus 14 qcvnl-ttrtqlppayt----nsftrgvyypdkvfrssvlhstqdlflpffsnvtwfhaihvsgtng--t-------krf 79 (1273) .|... ....-+++.++ -+-.+|+||||..++++..+-.|++|.+.-++.+-.- ++|++. + -.+ T Consensus 12 ~C~~~~~~~~~~~~~~~~~idvs~~~G~yYp~~rvysN~tlL~qglfp~~gs~~~~y~---~~~~~~~~~~~~~~~~~~y 88 (336) T 6J11_C 12 ACIEVDIQQTFFDKTWPRPIDVSKADGIIYPQGRTYSNITITYQGLFPYQGDHGDMYV---YSAGHATGTTPQKLFVANY 88 (336) T ss_dssp BCCCEEECGGGGCCCCCCCCCGGGTTTCBCCSSCCCCSEEEEEEEEECCTTCCCEEEC---CEECCBSSSCBCSEEECSC T ss_pred ceEEeccCccccCCCCCcceecccCceeEeeCCeeEeeeeeeeeccccCCCCcceEEE---EEecCCCCCCCcceeeecC Confidence 36664 23333444554 3446899999999999999999999999988877543 233332 2 356 Q sp|P0DTC2|SPIK 80 DNPVLPFNDGVYFASTEKSNIIRG-----------------WIFGTTLDSKT---Q------SLLIVNNATNVVI----- 128 (1273) Q Consensus 80 dnpvlpfndgvyfasteksniirg-----------------wifgttldskt---q------sllivnnatnvvi----- 128 (1273) +.+..||+||+++...+++|.-.+ ++||+|.+... + +++|+++-++.++ T Consensus 89 ~~~~~~F~dGifvkv~~~~n~t~~~~~~~~~~~~~~~~ypa~~fGstf~N~s~~~~~~~~~~tlvI~P~~~g~~~~~~~c 168 (336) T 6J11_C 89 SQDVKQFANGFVVRIGAAANSTGTVIISPSTSATIRKIYPAFMLGSSVGNFSDGKMGRFFNHTLVLLPDGCGTLLRAFYC 168 (336) T ss_dssp TTCCEECTTCEEEEESTTTTSEEECSSSTTCEEEEECCCCCEEEESCEEECTTSCEEEECSEEEEEEEETTTTEEEEEEE T ss_pred CCChhhccCeEEEEEeeeeccCCCeeecCccccchhhcccceEEecccccCCCCcceeecceEEEEecCCCCceeeeEee Confidence 788999999999999887776443 57999999777 6 8999999888765 Q sp|P0DTC2|SPIK 129 --KVCEFQFCNDPFLGVYYHKNN---KSWMES---------EFRVYSSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVF 194 (1273) Q Consensus 129 --kvcefqfcndpflgvyyhknn---kswmes---------efrvyssannctfeyvsqpflmdlegkqgnfknlrefvf 194 (1273) +.++..-|..|..-+++.-+. -+|+.+ +++.|..+.||+|.+.. .|-+|. +.+.|. |.| T Consensus 169 ~~~~rtit~C~~p~~~~~p~~~~~~~~~~~~~~~~~~~~~~~~~~f~~~~nc~f~~~~-nft~d~--~~~wf~----~~F 241 (336) T 6J11_C 169 ILEPRSGNHCPAGNSYTSFATYHTPATDCSDGNYNRNASLNSFKEYFNLRNCTFMYTY-NITEDE--ILEWFG----ITQ 241 (336) T ss_dssp EEEECCSBTSTTSTTCCCCCEEECHHHHCSSSSCCTTHHHHHHHHHEEEEEEEEEEEE-ECCCCC--CCEEEE----EEE T ss_pred eeccCccccCCCCCeEeeeeecCCCCccCCCccccccccccchhhhcccCCcEEEEee-ecCcch--hhheEe----EEE Confidence 333344566666655542221 345444 67788999999998753 444443 333443 999 Q sp|P0DTC2|SPIK 195 KNIDG-YFKIYSKHTPINL---VRDLPQGFSALEPLVDLPIGINITRFQTLLALHRSYLTPGDSSSGWTAGAAAYYVGYL 270 (1273) Q Consensus 195 knidg-yfkiyskhtpinl---vrdlpqgfsaleplvdlpiginitrfqtllalhrsyltpgdsssgwtagaaayyvgyl 270 (1273) ++.|| .|-+|--++..+. ...+| |...|.+..-+|..++ ++ .+.|. ..++|||++| T Consensus 242 ~~~~G~~f~~Y~~d~~~~~~f~f~~~~-g~~~l~yy~vip~s~~---------------~~---~~~~~-~~~ayyV~~L 301 (336) T 6J11_C 242 TAQGVHLFSSRYVDLYGGNMFQFATLP-VYDTIKYYSIIPHSIR---------------SI---QSDRK-AWAAFYVYKL 301 (336) T ss_dssp ETTEEEEEESTTTCTTTCCBEEEEEEC-CCSCCCEEEECCEEEC---------------CC---STTCC-EECCEEEEEC T ss_pred EeCCeeEEEEEEEccCCCcceeccccc-ceeccceeEeeeeeec---------------CC---cccce-eEEEEEEEEc Confidence 99999 9999887766653 55566 7777777664554443 22 45566 7899999999 Q sp|P0DTC2|SPIK 271 QPRTFLLKYNENGTITDAVDCALDPLSETKCTLKS 305 (1273) Q Consensus 271 qprtfllkynengtitdavdcaldplsetkctlks 305 (1273) .+|+|||.||+||.|++||||+-|+++|-||..+| T Consensus 302 ~~~~yLl~Fd~nG~It~AvDCa~d~~sELkCst~S 336 (336) T 6J11_C 302 QPLTFLLDFSVDGYIRRAIDCGFNDLSQLHCSYES 336 (336) T ss_dssp EEEEEEEEECSSSCEEEEEETTSSHHHHHHHHHCC T ss_pred ceeeEEEeccCCCeEEEEEecCCCcchhheeeecC Confidence 99999999999999999999999999999998764 No 47 >5GYQ_A Spike glycoprotein; bat coronavirus HKU9, putative receptor; HET: NAG; 2.1A {Bat coronavirus HKU9} Probab=99.70 E-value=4.2e-21 Score=188.88 Aligned_cols=108 Identities=29% Similarity=0.580 Sum_probs=104.5 Template_Neff=2.900 Q sp|P0DTC2|SPIK 332 ITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIA 411 (1273) Q Consensus 332 itnlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptklndlcftnvyadsfvirgdevrqia 411 (1273) |...|+|.++++ .++.+++.|.|+.++||..|+++|++.....+|+||||||.||.+.||..|+.|.|.|..+..++++ T Consensus 2 ~~~~C~~~~~l~-~~~PsP~nWeR~~fsNCnFN~S~Llslv~v~sf~C~gISPskLasmCfsSVTiD~FaIp~s~~~~Lq 80 (176) T 5GYQ_A 2 IQSYCTPPYSVL-QDPPQPVVWRRYMLYDCVFDFTVVVDSLPTHQLQCYGVSPRRLASMCYGSVTLDVMRINETHLNNLF 80 (176) T ss_dssp CCEECCCCHHHH-HSCCCGGGCEEEEECSEEECGGGGTTSSCEEEEEEESSCHHHHTTSCBSEEEEEEEEECHHHHHHHH T ss_pred CCCCCCCChHhc-CCCCCCceeEEEEEeccCCchHHHHhhceeeeeeeeCCCHHHHhhcccceeEEEEEEeChHHHHhhc Confidence 567899999999 9999999999999999999999999999999999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 412 PGQTGKIADYNYKLPDDFTGCVIAWNSNN 440 (1273) Q Consensus 412 pgqtgkiadynyklpddftgcviawnsnn 440 (1273) +|++|-|++||||+|+||+||+++|+-+. T Consensus 81 ~GssG~i~~yNYKlp~~f~gC~l~y~l~~ 109 (176) T 5GYQ_A 81 NRVPDTFSLYNYALPDNFYGCLHAFYLNS 109 (176) T ss_dssp HTCCCHHHHHTCCCCTTCCEEEEEEEEEE T ss_pred CCCCcHHHhccccCCCCCCceEEEEEcCC Confidence 99999999999999999999999997653 No 48 >5ZVK_A Human Coronavirus MERS HR1 motif; MERS, Spike protein, S2 domain; 3.31A {Middle East respiratory syndrome-related coronavirus} Probab=99.68 E-value=7.3e-21 Score=169.61 Aligned_cols=79 Identities=56% Similarity=0.816 Sum_probs=69.9 Template_Neff=3.000 Q sp|P0DTC2|SPIK 910 GVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVE 988 (1273) Q Consensus 910 gvtqnvlyenqklianqfnsaigkiqdslsstasalgklqdvvnqnaqalntlvkqlssnfgaissvlndilsrldkve 988 (1273) |+|++||.||||+||+.||.|+|.|++.+.++++||.|+|||||++++||+.|+.||+.|||||||.++||.+|||++| T Consensus 2 glt~~VL~~NQk~iA~sFN~A~~~i~~~~~t~~~AL~kiQ~VVN~q~~aL~~L~~qL~~NFgAISssI~dIy~RLd~le 80 (80) T 5ZVK_A 2 GITQQVLSENQKLIANKFNQALGAMQTGFTTTNEAFRKVQDAVNNNAQALSKLASELSNTFGAISASIGDIIQRLDVLE 80 (80) T ss_dssp --CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC------- T ss_pred CcchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhHHHHHHHHHHHHHHhcC Confidence 7899999999999999999999999999999999999999999999999999999999999999999999999999986 No 49 >2BEZ_C E2 GLYCOPROTEIN; MEMBRANE FUSION, SEVERE ACUTE RESPIRATORY; 1.6A {SARS CORONAVIRUS} SCOP: h.3.3.1 Probab=99.63 E-value=8.5e-20 Score=162.03 Aligned_cols=77 Identities=88% Similarity=1.101 Sum_probs=75.2 Template_Neff=3.000 Q sp|P0DTC2|SPIK 914 NVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAE 990 (1273) Q Consensus 914 nvlyenqklianqfnsaigkiqdslsstasalgklqdvvnqnaqalntlvkqlssnfgaissvlndilsrldkveae 990 (1273) +||.||||+||+.||.|++.|+..++++++||.|+|||||++++||+.|+.||+.|||||||.++||.+|||++||. T Consensus 1 ~VL~~NQk~iA~sFN~A~~~i~~~~~t~s~AL~kiQ~VVN~q~~aL~~L~~qL~~nFgAISssI~dIy~RLd~leAd 77 (77) T 2BEZ_C 1 NVLYENQKQIANQFNKAISQIQESLTTTSTALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAE 77 (77) T ss_dssp CCSSSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC T ss_pred ChhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhHHHHHHHHHHHHHHHHhcC Confidence 58999999999999999999999999999999999999999999999999999999999999999999999999984 No 50 >6M1V_A spike protein; 2019-nCoV, spike protein, fusion core; 1.5A {Severe acute respiratory syndrome coronavirus 2} Probab=99.60 E-value=2.8e-19 Score=168.19 Aligned_cols=98 Identities=56% Similarity=0.575 Sum_probs=68.4 Template_Neff=3.400 Q sp|P0DTC2|SPIK 917 YENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRL 996 (1273) Q Consensus 917 yenqklianqfnsaigkiqdslsstasalgklqdvvnqnaqalntlvkqlssnfgaissvlndilsrldkveaevqidrl 996 (1273) .||||+||+.||.|+|.|++.++++++||.|+|||||++++||+.|+.||+.|||||||.+. |++||.+|+||+ T Consensus 1 ~~NQk~lA~sFN~A~~~i~~~~~t~~~Al~kiQ~VVN~q~~aL~~L~~qL~~nf~aisssi~------~~lea~~q~drl 74 (119) T 6M1V_A 1 MENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLLVPRGSGGSGGS------GGLEVLFQGPDV 74 (119) T ss_dssp CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHSCC-------------------------- T ss_pred ChHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhhccCCCcchhh------hhHHHhhcCCCc Confidence 38999999999999999999999999999999999999999999999999999999999977 899999999999 Q sp|P0DTC2|SPIK 997 ITGRLQSLQTYVTQQLIRAAEIRA 1020 (1273) Q Consensus 997 itgrlqslqtyvtqqliraaeira 1020 (1273) ++|||..+..++++-....++++. T Consensus 75 itgrLsaLNatvldL~~Ei~~Lqe 98 (119) T 6M1V_A 75 DLGDISGINASVVNIQKEIDRLNE 98 (119) T ss_dssp ----CTTCCCCCCCCHHHHHHHHH T ss_pred CCCChHHhhHHHHHHHHHHHHHHH Confidence 999999999999887666655543 No 51 >5ZUV_A Spike glycoprotein,EK1, Spike glycoprotein,inhibitor EK1; Human Coronavirus 229E, Spike protein; 2.21A {Human coronavirus 229E} Probab=99.56 E-value=1.2e-18 Score=166.05 Aligned_cols=83 Identities=47% Similarity=0.646 Sum_probs=77.2 Template_Neff=2.400 Q sp|P0DTC2|SPIK 914 NVLYENQKLIANQFNSAIGKIQDS--------------LSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLND 979 (1273) Q Consensus 914 nvlyenqklianqfnsaigkiqds--------------lsstasalgklqdvvnqnaqalntlvkqlssnfgaissvlnd 979 (1273) +||.||||+||+.||.|||.|+.. ++++++||.|+|||||++++||+.|++||+.|||||||.++| T Consensus 2 dVLq~NQkiiA~SFN~AignI~~aF~~vn~ai~qts~~~~Tva~AL~KIQdVVN~qg~AL~~Lt~QL~nNFqAISSSIqD 81 (133) T 5ZUV_A 2 DVLQENQKILAASFNKAMTNIVDAFTGVNDAITQTSQALQTVATALNKIQDVVNQQGNSLNHLTSQLRQNFQAISSSIQA 81 (133) T ss_dssp --CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred cHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 689999999999999999999966 566779999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 980 ILSRLDKVEAEVQIDRL 996 (1273) Q Consensus 980 ilsrldkveaevqidrl 996 (1273) |.+|||++||.++.++| T Consensus 82 IY~RLD~leAd~~~gsl 98 (133) T 5ZUV_A 82 IYDRLDTIQSGGRGGSL 98 (133) T ss_dssp HHHHHTCSSCCCCSCCC T ss_pred HHHHHHHHHhhhccCcc Confidence 99999999999998776 No 52 >5YL9_A Spike glycoprotein; Spike protein, 6-helical bundle, post-fusion; 1.861A {Human coronavirus 229E} Probab=99.49 E-value=1.1e-17 Score=151.89 Aligned_cols=74 Identities=51% Similarity=0.726 Sum_probs=70.0 Template_Neff=2.900 Q sp|P0DTC2|SPIK 914 NVLYENQKLIANQFNSAIGKIQDS--------------LSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLND 979 (1273) Q Consensus 914 nvlyenqklianqfnsaigkiqds--------------lsstasalgklqdvvnqnaqalntlvkqlssnfgaissvlnd 979 (1273) +||.||||+||+.||.|||.|+.. ++++++||.|+|||||++++||+.|.+||+.|||||||.++| T Consensus 2 ~VLq~NQk~iA~sFN~Aigni~~af~~vn~ai~qts~~~~tva~AL~KiQ~VVN~q~~aL~~Lt~QL~~NF~AISsSI~d 81 (89) T 5YL9_A 2 DVLQENQKILAASFNKAMTNIVDAFTGVNDAITQTSQALQTVATALNKIQDVVNQQGNSLNHLTSQLRQNFQAISSSIQA 81 (89) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred cHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 689999999999999999999977 556679999999999999999999999999999999999999 Q sp|P0DTC2|SPIK 980 ILSRLDKV 987 (1273) Q Consensus 980 ilsrldkv 987 (1273) |.+|||++ T Consensus 82 Iy~RLd~l 89 (89) T 5YL9_A 82 IYDRLDTI 89 (89) T ss_dssp HHHHHHHC T ss_pred HHHHHhcC Confidence 99999974 No 53 >1WDF_B E2 glycoprotein; MHV, coronavirus, heptad repeat, fusion; 2.5A {Murine hepatitis virus} SCOP: h.3.3.1 Probab=99.16 E-value=2.7e-14 Score=131.27 Aligned_cols=62 Identities=60% Similarity=0.836 Sum_probs=58.6 Template_Neff=2.400 Q sp|P0DTC2|SPIK 919 NQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDI 980 (1273) Q Consensus 919 nqklianqfnsaigkiqdslsstasalgklqdvvnqnaqalntlvkqlssnfgaissvlndi 980 (1273) |||.||+.||.|||.||+.++++++||.|+|||||++++||+.|+.||+.|||||||++.|. T Consensus 1 NQkiLAnsFN~AignIq~af~tts~AL~KIQdVVN~qg~AL~~Lt~QL~~NFgAISSsi~d~ 62 (95) T 1WDF_B 1 NQKMIASAFNNALGAIQDGFDATNSALGKIQSVVNANAEALNNLLNQLSNRFGAISDLSLDF 62 (95) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTCC--CCCCCG T ss_pred CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhHchHHHHHHHH Confidence 79999999999999999999999999999999999999999999999999999999999875 No 54 >1ZVA_A E2 glycoprotein; SARS coronavirus, membrane fusion, S2; 1.5A {SARS coronavirus} SCOP: h.3.3.1 Probab=99.05 E-value=1.7e-13 Score=121.91 Aligned_cols=58 Identities=66% Similarity=0.811 Sum_probs=47.6 Template_Neff=4.100 Q sp|P0DTC2|SPIK 1144 ELDSFKEELDKYFKNHTSPDVDLGD-----ISGINASVVNIQKEIDRLNEVAKNLNESLIDLQ 1201 (1273) Q Consensus 1144 eldsfkeeldkyfknhtspdvdlgd-----isginasvvniqkeidrlnevaknlneslidlq 1201 (1273) .|..|++||+|+||+++|.-.|+.+ ++++|+++++++.||+||+||+|+||||+|||+ T Consensus 15 ~L~~f~~eL~~~FkaiSSsi~di~~rl~grLs~lNa~vl~l~~Ei~~L~~vik~LN~S~IdLk 77 (77) T 1ZVA_A 15 ALNTLVKQLSSNFGAISSVLNDISGGRGGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQ 77 (77) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHTTSCCCCTTHHHHHHHHHHHHHHHHHHHHHHHHHHHC-- T ss_pred HHHHHHHHHHHHhchhhhchhhhcCCCCCChhhhcHHHHHHHHHHHHHHHHHHHHHHhhhccC Confidence 4566777777777777776655554 999999999999999999999999999999985 No 55 >5ZHY_D Spike glycoprotein,Spike glycoprotein; membrane fusion, broad-spectrum inhibitor design; 2.441A {Human coronavirus 229E} Probab=98.79 E-value=7.4e-12 Score=121.97 Aligned_cols=59 Identities=47% Similarity=0.667 Sum_probs=37.2 Template_Neff=2.300 Q sp|P0DTC2|SPIK 918 ENQKLIANQFNSAIGKIQDS--------------LSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSV 976 (1273) Q Consensus 918 enqklianqfnsaigkiqds--------------lsstasalgklqdvvnqnaqalntlvkqlssnfgaissv 976 (1273) ||||+||+.||.|||.|+.. ++++|+||.|+|||||+.++||+.|.+||+.||||||+- T Consensus 1 ~NQkiLAnSFN~AignIt~aF~~Vn~Ai~qts~~~~Tva~AL~KIQdVVN~Qg~ALs~Lt~QL~nNFqAIS~~ 73 (148) T 5ZHY_D 1 ENQKILAASFNKAMTNIVDAFTGVNDAITQTSQALQTVATALNKIQDVVNQQGNSLNHLTSQLRQNFQLVPRG 73 (148) T ss_dssp -----CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTCC-------------- T ss_pred ChHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhcCCcccc Confidence 69999999999999999966 555679999999999999999999999999999999974 No 56 >5XJK_A Spike protein S2; VIRAL PROTEIN; NMR {Human SARS coronavirus} Probab=98.74 E-value=1.4e-11 Score=106.98 Aligned_cols=62 Identities=85% Similarity=1.326 Sum_probs=57.8 Template_Neff=4.400 Q sp|P0DTC2|SPIK 777 NTQEVFAQVKQIYKTPPIKDFGGFNFSQILPDPSKPSKRSFIEDLLFNKVTLADAGFIKQYG 838 (1273) Q Consensus 777 ntqevfaqvkqiyktppikdfggfnfsqilpdpskpskrsfiedllfnkvtladagfikqyg 838 (1273) +..+++..+|+-+++|-+..|+||||+.+||.+++++.||+||||||+||.++|.||++.|. T Consensus 3 ~~~~~~s~~~~~~~l~~~~~~~~fN~s~lL~~~~~~~~RSaIEDLLF~KV~t~~~G~v~~Yk 64 (65) T 5XJK_A 3 NTREVFAQVKQMYKTPTLKYFGGFNFSQILPSPLKPTKRSFIEDLLFNKVTLADAGFMKQYG 64 (65) T ss_dssp TTGGGHHHHTTCCCCCCCSSSCCCCGGGSSCCCCCCCGGGGGGHHHHTTTSSTTHHHHHGGG T ss_pred cHHHHHHHHHHHhcCCcccccCCccccccCCCCCCCCCccHHHHHhccceeecCcchhhhhc Confidence 34678899999999999999999999999999999999999999999999999999998885 No 57 >1ZV8_K E2 glycoprotein; SARS coronavirus, membrane fusion, S2; 1.94A {SARS coronavirus} SCOP: h.3.3.1 Probab=98.55 E-value=1.2e-10 Score=98.26 Aligned_cols=50 Identities=82% Similarity=0.987 Sum_probs=48.5 Template_Neff=3.100 Q sp|P0DTC2|SPIK 919 NQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSS 968 (1273) Q Consensus 919 nqklianqfnsaigkiqdslsstasalgklqdvvnqnaqalntlvkqlss 968 (1273) |||+||+.||.||+.|++.++++++||.|+|||||++++||+.|..||+. T Consensus 1 NQk~iA~sFN~Ai~~i~~g~~t~~~AL~KiQ~VVN~q~~aL~~Lt~qL~~ 50 (50) T 1ZV8_K 1 NQKQIANQFNKAISQIQESLTTTSTALGKLQDVVNQNAQALNTLVKQLSS 50 (50) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC T ss_pred CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhC Confidence 79999999999999999999999999999999999999999999999963 No 58 >2IEQ_B Spike glycoprotein; Human coronavirus membrane fusion; 1.747A {Human coronavirus} Probab=98.54 E-value=1.3e-10 Score=109.56 Aligned_cols=84 Identities=33% Similarity=0.293 Sum_probs=64.1 Template_Neff=3.500 Q sp|P0DTC2|SPIK 921 KLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISS-VLNDIL--------SRLDKVEAEV 991 (1273) Q Consensus 921 klianqfnsaigkiqdslsstasalgklqdvvnqnaqalntlvkqlssnfgaiss-vlndil--------srldkveaev 991 (1273) .+-.+.||.||+.||+.++++++||.|+|||||+.+++|+.|..||..||++|+. .+ ||. +|+|+.|++. T Consensus 7 t~a~~~fn~Ai~~i~~g~~tt~~AL~KIQ~VVN~q~~tL~~Ll~QL~nNF~Ais~~~l-difN~T~LNLT~Ei~~LE~ra 85 (109) T 2IEQ_B 7 VASFSSVNDAITQTAEAIHTVTIALNKIQDVVNQQGSALNHLTSQLRHNFQSGGRGSG-RGGNLTYLNLSSELKQLEAKT 85 (109) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC-----------------CCCCCCHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhhcccCCCCccCC-cchHhhhcchhHHHHHHHHHH Confidence 3456899999999999999999999999999999999999999999999999999 67 999 9999999999 Q sp|P0DTC2|SPIK 992 QIDRLITGRLQSLQ 1005 (1273) Q Consensus 992 qidrlitgrlqslq 1005 (1273) +-=+-++-.||.+- T Consensus 86 ~~L~~~~~eLq~~I 99 (109) T 2IEQ_B 86 ASLFQTTVELQGLI 99 (109) T ss_dssp HHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHH Confidence 88888888877653 No 59 >2FXP_A Spike glycoprotein; Prefusion Intermediate, Trimer, Coiled-coil, VIRAL; NMR {SARS coronavirus} SCOP: h.3.3.1 Probab=98.52 E-value=1.6e-10 Score=98.19 Aligned_cols=54 Identities=98% Similarity=1.317 Sum_probs=52.8 Template_Neff=4.100 Q sp|P0DTC2|SPIK 1158 NHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIK 1211 (1273) Q Consensus 1158 nhtspdvdlgdisginasvvniqkeidrlnevaknlneslidlqelgkyeqyik 1211 (1273) |||+|+.++.++..+|++++|++.||++|+++.|+||+++|||++|++||+||| T Consensus 2 n~t~~~~~~~~l~~~N~t~LnLt~Ei~~Lq~~I~~LN~s~IdLe~Ln~~etYiK 55 (55) T 2FXP_A 2 SHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIK 55 (55) T ss_dssp CSCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTTTTCCC T ss_pred CCCCCCCCCCccccccccccchHHHHHHHHHHHHHHhhcCCCHHHhccceeecC Confidence 799999999999999999999999999999999999999999999999999998 No 60 >1WDG_B E2 glycoprotein; MHV, coronavirus, heptad repeat, fusion; 2.06A {Murine hepatitis virus} SCOP: h.3.3.1 Probab=98.49 E-value=2.2e-10 Score=106.06 Aligned_cols=54 Identities=57% Similarity=0.760 Sum_probs=48.6 Template_Neff=3.000 Q sp|P0DTC2|SPIK 919 NQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSS--NFGA 972 (1273) Q Consensus 919 nqklianqfnsaigkiqdslsstasalgklqdvvnqnaqalntlvkqlss--nfga 972 (1273) |||+||+.||.|||.||+.++++++||.|+|||||++++||+.|..||+. |++. T Consensus 1 NQk~iA~sFN~Aigni~~~f~~~~~AL~kiQ~VVN~q~~aL~~LtNQLS~~pn~~~ 56 (94) T 1WDG_B 1 NQKMIASAFNNALGAIQDGFDATNSALGKIQSVVNANAEALNNLLNQLSLVPRGSG 56 (94) T ss_dssp -CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTCCC------ T ss_pred ChHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhcCCCCCC Confidence 79999999999999999999999999999999999999999999999998 7777 No 61 >2BEQ_D E2 GLYCOPROTEIN; VIRAL PROTEIN, COILED COIL, MEMBRANE; HET: ACE; 1.6A {N/A} Probab=98.41 E-value=5.2e-10 Score=93.68 Aligned_cols=47 Identities=98% Similarity=1.271 Sum_probs=44.9 Template_Neff=3.400 Q sp|P0DTC2|SPIK 1166 LGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIKW 1212 (1273) Q Consensus 1166 lgdisginasvvniqkeidrlnevaknlneslidlqelgkyeqyikw 1212 (1273) ++|++.+|++++|++.||++|+++.|+||+|+|||++|++||+|||| T Consensus 2 ~~~l~~~N~t~LnLs~Ei~~Lq~~I~~LN~s~IdLe~Ln~~etYiKW 48 (48) T 2BEQ_D 2 LGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIKX 48 (48) T ss_dssp CCSCTTCCCCCCCCHHHHHHHHHHHTTGGGGEECHHHHHHHHHHHC- T ss_pred CCCccccccccccHHHHHHHHHHHHHHHHhcCCCHHHhcccchhcCC Confidence 67889999999999999999999999999999999999999999999 No 62 >2BEQ_E E2 GLYCOPROTEIN; VIRAL PROTEIN, COILED COIL, MEMBRANE; HET: ACE; 1.6A {N/A} Probab=98.41 E-value=5.2e-10 Score=93.68 Aligned_cols=47 Identities=98% Similarity=1.271 Sum_probs=44.3 Template_Neff=3.400 Q sp|P0DTC2|SPIK 1166 LGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIKW 1212 (1273) Q Consensus 1166 lgdisginasvvniqkeidrlnevaknlneslidlqelgkyeqyikw 1212 (1273) ++|++.+|++++|++.||++|+++.|+||+|+|||++|++||+|||| T Consensus 2 ~~~l~~~N~t~LnLs~Ei~~Lq~~I~~LN~s~IdLe~Ln~~etYiKW 48 (48) T 2BEQ_E 2 LGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIKX 48 (48) T ss_dssp -CTTTTCCCCCCCCHHHHHHHHHHHHTGGGTEEEHHHHHHHHHHHC- T ss_pred CCCccccccccccHHHHHHHHHHHHHHHHhcCCCHHHhcccchhcCC Confidence 67889999999999999999999999999999999999999999999 No 63 >6LXT_F Spike protein S2; 2019-nCoV, HR1 and HR2 domain; HET: PG4; 2.9A {Severe acute respiratory syndrome coronavirus 2} Probab=97.71 E-value=1.4e-07 Score=91.83 Aligned_cols=45 Identities=98% Similarity=1.275 Sum_probs=36.7 Template_Neff=2.500 Q sp|P0DTC2|SPIK 1163 DVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYE 1207 (1273) Q Consensus 1163 dvdlgdisginasvvniqkeidrlnevaknlneslidlqelgkye 1207 (1273) .+..|.++.+||.|...|.|+.+|||||||||||||||||||||. T Consensus 87 RLItGRLaaLna~v~q~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 131 (132) T 6LXT_F 87 DVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYG 131 (132) T ss_dssp ---CCCCTTCCCCCCCCHHHHHHHHHHHHHGGGGSCCCCC----- T ss_pred chhcccHHHHHHHHHHHHHHHHHHHHHHHHHhHHhchHHHhHhcC Confidence 467899999999999999999999999999999999999999994 No 64 >6LXT_C 2019-nCoV S2 subunit; 2019-nCoV, HR1 and HR2 domain; HET: PG4; 2.9A {COVID-19 virus} Probab=97.71 E-value=1.4e-07 Score=91.83 Aligned_cols=45 Identities=98% Similarity=1.275 Sum_probs=38.5 Template_Neff=2.500 Q sp|P0DTC2|SPIK 1163 DVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYE 1207 (1273) Q Consensus 1163 dvdlgdisginasvvniqkeidrlnevaknlneslidlqelgkye 1207 (1273) .+..|.++.+||.|...|.|+.+|||||||||||||||||||||. T Consensus 87 RLItGRLaaLna~v~q~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 131 (132) T 6LXT_C 87 DVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYG 131 (132) T ss_dssp CCCCCCCTTCCCCCCCCHHHHHHHHHHHHHGGGGCCCCCC----- T ss_pred chhcccHHHHHHHHHHHHHHHHHHHHHHHHHhHHhchHHHhHhcC Confidence 467899999999999999999999999999999999999999994 No 65 >4MOD_B HR1 of S protein, LINKER; MERS-CoV, Viral envelope proteins, Spike; 1.901A {Human betacoronavirus 2c EMC/2012} Probab=97.52 E-value=4.8e-07 Score=88.04 Aligned_cols=64 Identities=33% Similarity=0.482 Sum_probs=36.9 Template_Neff=3.100 Q sp|P0DTC2|SPIK 1142 QPELDSFKEELDKYFKNHTSPDVDL--------------------GDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQ 1201 (1273) Q Consensus 1142 qpeldsfkeeldkyfknhtspdvdl--------------------gdisginasvvniqkeidrlnevaknlneslidlq 1201 (1273) ...|..|++||+++||+++|.-.|+ |.++.+|+++++++.|+.+|++|.|.||||.|||+ T Consensus 40 ~~aL~~l~~EL~knFkAISSsI~dIy~rld~~~~~ad~qvdrLitgrL~~LNa~~~dl~~em~~l~~vvk~LNes~idlk 119 (129) T 4MOD_B 40 AQALSKLASELSNTFGAISASIGDILVPRGSGGSGGSGGLEVLFQGPLTQINTTLLDLTYEMLSLQQVVKALNESYIDLK 119 (129) T ss_dssp HHHHHHHHHC---------------------------------------CCCCCCCCCHHHHHHHHHHHHHHHTTCCC-- T ss_pred HHHHHHHHHHHHHHhCcchhhHHHhhhccCCCCCCccccchhhcCCChHHHHHHHHHHHHHHHHHHHHHHHHHHHhhcHH Confidence 3568899999999999999987776 45777999999999999999999999999999999 Q sp|P0DTC2|SPIK 1202 ELGK 1205 (1273) Q Consensus 1202 elgk 1205 (1273) ||-. T Consensus 120 el~~ 123 (129) T 4MOD_B 120 ELLE 123 (129) T ss_dssp ---- T ss_pred HHHh Confidence 9854 No 66 >1ZVB_A E2 glycoprotein; SARS coronavirus, membrane fusion, S2; 1.7A {SARS coronavirus} SCOP: h.3.3.1 Probab=97.29 E-value=1.9e-06 Score=69.03 Aligned_cols=34 Identities=100% Similarity=1.192 Sum_probs=32.0 Template_Neff=3.100 Q sp|P0DTC2|SPIK 958 ALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEV 991 (1273) Q Consensus 958 alntlvkqlssnfgaissvlndilsrldkveaev 991 (1273) ||+.|+.||+.|||||||.++||.+|||++||.+ T Consensus 1 al~~L~~qL~nnF~aISssI~di~~RLD~leA~~ 34 (34) T 1ZVB_A 1 ALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEV 34 (34) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTC T ss_pred CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhcC Confidence 5889999999999999999999999999999864 No 67 >1WDG_B E2 glycoprotein; MHV, coronavirus, heptad repeat, fusion; 2.06A {Murine hepatitis virus} SCOP: h.3.3.1 Probab=97.10 E-value=5.1e-06 Score=77.92 Aligned_cols=47 Identities=30% Similarity=0.468 Sum_probs=29.3 Template_Neff=3.000 Q sp|P0DTC2|SPIK 1156 FKNHTSPDVDLGD----ISGINASVVNIQKEIDRLNEVAKNLNESLIDLQE 1202 (1273) Q Consensus 1156 fknhtspdvdlgd----isginasvvniqkeidrlnevaknlneslidlqe 1202 (1273) .-++++...++++ +++||++.+++++|+++|+||.|.||||.|||+| T Consensus 44 LtNQLS~~pn~~~~~~~~~~iN~t~lDl~~Em~~lq~vvk~LNeS~IdLKe 94 (94) T 1WDG_B 44 LLNQLSLVPRGSGGSGGSGGLNVTLLDLTYEMNRIQDAIKKLNESYINLKE 94 (94) T ss_dssp HHTTCCC-------------------CCHHHHHHHHHHHHHHHTTCCCTTC T ss_pred HHHHHhcCCCCCCCCCCcccchhhhHHHHHHHHHHHHHHHHHHHHhhcccC Confidence 4577777777777 9999999999999999999999999999999986 No 68 >6M1V_A spike protein; 2019-nCoV, spike protein, fusion core; 1.5A {Severe acute respiratory syndrome coronavirus 2} Probab=96.99 E-value=8.6e-06 Score=78.78 Aligned_cols=49 Identities=86% Similarity=1.074 Sum_probs=35.8 Template_Neff=3.400 Q sp|P0DTC2|SPIK 1157 KNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGK 1205 (1273) Q Consensus 1157 knhtspdvdlgdisginasvvniqkeidrlnevaknlneslidlqelgk 1205 (1273) .+-+.+..++|+++.+|+++++++.||++|+||.|+||||+|||+||.. T Consensus 67 a~~q~drlitgrLsaLNatvldL~~Ei~~LqevIk~LN~S~IDLk~~~~ 115 (119) T 6M1V_A 67 VLFQGPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELHH 115 (119) T ss_dssp ------------CTTCCCCCCCCHHHHHHHHHHHHHGGGGSCCGGGSCC T ss_pred HhhcCCCcCCCChHHhhHHHHHHHHHHHHHHHHHHHHHHHcccHHHhhc Confidence 3456677888999999999999999999999999999999999999864 No 69 >2BEQ_C E2 GLYCOPROTEIN; VIRAL PROTEIN, COILED COIL, MEMBRANE; HET: ACE; 1.6A {N/A} SCOP: h.3.3.1 Probab=96.96 E-value=9.9e-06 Score=66.07 Aligned_cols=36 Identities=81% Similarity=0.995 Sum_probs=34.2 Template_Neff=3.500 Q sp|P0DTC2|SPIK 932 GKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLS 967 (1273) Q Consensus 932 gkiqdslsstasalgklqdvvnqnaqalntlvkqls 967 (1273) +.||+.++++++||.|+|||||++++||+.|.+||+ T Consensus 2 ~~iq~gf~tta~AL~KIQ~VVN~qg~aL~~Lt~QL~ 37 (38) T 2BEQ_C 2 SQIQESLTTTSTALGKLQDVVNQNAQALNTLVKQLS 37 (38) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC T ss_pred CchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhC Confidence 568999999999999999999999999999999996 No 70 >5ZVM_c Human Coronavirus SARS HR1 motif; SARS, Spike protein, S2 domain; 3.3A {Human SARS coronavirus} Probab=96.74 E-value=2.6e-05 Score=65.26 Aligned_cols=41 Identities=39% Similarity=0.648 Sum_probs=38.1 Template_Neff=3.500 Q sp|P0DTC2|SPIK 1165 DLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGK 1205 (1273) Q Consensus 1165 dlgdisginasvvniqkeidrlnevaknlneslidlqelgk 1205 (1273) .++|+..+|++++|++.||++|+++.|+||+++|||++|++ T Consensus 4 ~~~~l~~~N~t~LnLt~Ei~~Lq~~Ik~LN~s~IDLe~Lnr 44 (44) T 5ZVM_c 4 RGGSLDQINVTFLDLEYEMKKLEEAIKKLEESYIDLKELGG 44 (44) T ss_dssp HHHCCTTCCCCCCCCHHHHHHHHHHHHHHHTTCCCCCCCTT T ss_pred CCCChhhccccccchHHHHHHHHHHHHHHHhhcCCHHHhCC Confidence 46788899999999999999999999999999999999874 No 71 >5ZVM_b Human Coronavirus SARS HR1 motif; SARS, Spike protein, S2 domain; 3.3A {Human SARS coronavirus} Probab=96.74 E-value=2.6e-05 Score=65.26 Aligned_cols=41 Identities=39% Similarity=0.648 Sum_probs=38.1 Template_Neff=3.500 Q sp|P0DTC2|SPIK 1165 DLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGK 1205 (1273) Q Consensus 1165 dlgdisginasvvniqkeidrlnevaknlneslidlqelgk 1205 (1273) .++|+..+|++++|++.||++|+++.|+||+++|||++|++ T Consensus 4 ~~~~l~~~N~t~LnLt~Ei~~Lq~~Ik~LN~s~IDLe~Lnr 44 (44) T 5ZVM_b 4 RGGSLDQINVTFLDLEYEMKKLEEAIKKLEESYIDLKELGG 44 (44) T ss_pred CCCChhhcccccccHHHHHHHHHHHHHHHHhhccChHHhcC Confidence 46788899999999999999999999999999999999874 No 72 >2BEZ_F E2 GLYCOPROTEIN; MEMBRANE FUSION, SEVERE ACUTE RESPIRATORY; 1.6A {SARS CORONAVIRUS} Probab=96.44 E-value=8.7e-05 Score=61.42 Aligned_cols=42 Identities=100% Similarity=1.270 Sum_probs=37.4 Template_Neff=4.100 Q sp|P0DTC2|SPIK 1160 TSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQ 1201 (1273) Q Consensus 1160 tspdvdlgdisginasvvniqkeidrlnevaknlneslidlq 1201 (1273) ||+..++.++..+|++++|++.||++|+++.|+||+++|||+ T Consensus 1 ts~~p~~~~l~~~N~t~LnLt~Ei~~Lq~~I~~LN~slIdLe 42 (42) T 2BEZ_F 1 TSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQ 42 (42) T ss_dssp CCCCCCCCCCTTCCCCCCCCHHHHHHHHHHHHHTSTTSCCCC T ss_pred CCCCcCcccccccccccccHHHHHHHHHHHHHHHHhccccCC Confidence 455566666889999999999999999999999999999985 No 73 >6LVN_B 2019-nCoV S2 subunit; 2019-nCoV, HR2 domain, VIRUS, VIRAL; 2.47A {COVID-19 virus} Probab=96.21 E-value=0.00019 Score=58.12 Aligned_cols=35 Identities=100% Similarity=1.213 Sum_probs=32.6 Template_Neff=3.900 Q sp|P0DTC2|SPIK 1169 ISGINASVVNIQKEIDRLNEVAKNLNESLIDLQEL 1203 (1273) Q Consensus 1169 isginasvvniqkeidrlnevaknlneslidlqel 1203 (1273) +..+|++++|++.||++|+++.|+||+|+|||++| T Consensus 2 ~~~~N~t~Lnlt~Ei~~lq~~I~~LN~s~IdLe~L 36 (36) T 6LVN_B 2 ISGINASVVNIQKEIDRLNEVAKNLNESLIDLQEL 36 (36) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTC T ss_pred CcccccccccHHHHHHHHHHHHHHHHhhcCChhhC Confidence 45689999999999999999999999999999875 No 74 >1ZV8_B E2 glycoprotein; SARS coronavirus, membrane fusion, S2; 1.94A {SARS coronavirus} Probab=96.21 E-value=0.00019 Score=58.12 Aligned_cols=35 Identities=100% Similarity=1.213 Sum_probs=26.7 Template_Neff=3.900 Q sp|P0DTC2|SPIK 1169 ISGINASVVNIQKEIDRLNEVAKNLNESLIDLQEL 1203 (1273) Q Consensus 1169 isginasvvniqkeidrlnevaknlneslidlqel 1203 (1273) +..+|++++|++.||++|+++.|+||+|+|||++| T Consensus 2 ~~~~N~t~Lnlt~Ei~~lq~~I~~LN~s~IdLe~L 36 (36) T 1ZV8_B 2 ISGINASVVNIQKEIDRLNEVAKNLNESLIDLQEL 36 (36) T ss_dssp ---CCCCCCCCHHHHHHHHHHHHHGGGGCC----- T ss_pred CcccccccccHHHHHHHHHHHHHHHHhhcCChhhC Confidence 45689999999999999999999999999999875 No 75 >6LVN_A Spike protein S2; 2019-nCoV, HR2 domain, VIRUS, VIRAL; 2.47A {Severe acute respiratory syndrome coronavirus 2} Probab=96.21 E-value=0.00019 Score=58.12 Aligned_cols=35 Identities=100% Similarity=1.213 Sum_probs=32.0 Template_Neff=3.900 Q sp|P0DTC2|SPIK 1169 ISGINASVVNIQKEIDRLNEVAKNLNESLIDLQEL 1203 (1273) Q Consensus 1169 isginasvvniqkeidrlnevaknlneslidlqel 1203 (1273) +..+|++++|++.||++|+++.|+||+|+|||++| T Consensus 2 ~~~~N~t~Lnlt~Ei~~lq~~I~~LN~s~IdLe~L 36 (36) T 6LVN_A 2 ISGINASVVNIQKEIDRLNEVAKNLNESLIDLQEL 36 (36) T ss_dssp CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC- T ss_pred CcccccccccHHHHHHHHHHHHHHHHhhcCChhhC Confidence 45689999999999999999999999999999875 No 76 >5YL9_B Spike glycoprotein; Spike protein, 6-helical bundle, post-fusion; 1.861A {Human coronavirus 229E} Probab=91.73 E-value=0.063 Score=48.02 Aligned_cols=41 Identities=29% Similarity=0.567 Sum_probs=34.5 Template_Neff=3.600 Q sp|P0DTC2|SPIK 1158 NHTSPDVDLGDISGINASVVNIQKEIDR--------------LNEVAKNLNESLIDLQ 1201 (1273) Q Consensus 1158 nhtspdvdlgdisginasvvniqkeidr--------------lnevaknlneslidlq 1201 (1273) .|+.||.+ +...|+.+.|+..||++ |.++.++||.+++||+ T Consensus 4 ~~t~pdl~---ld~yN~tiLNLt~EI~~Le~rs~~L~~~~~~Lq~~I~nLN~TlVDLE 58 (59) T 5YL9_B 4 RGGVPDLV---VEQYNQTILNLTSEISTLENKSAELNYTVQKLQTLIDNINSTLVDLK 58 (59) T ss_dssp -CCCCCCC---CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTCCCCC T ss_pred CCCCCCcc---cccccceecccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhccccC Confidence 57888884 57789999999999999 7788888888888875 No 77 >5ZUV_A Spike glycoprotein,EK1, Spike glycoprotein,inhibitor EK1; Human Coronavirus 229E, Spike protein; 2.21A {Human coronavirus 229E} Probab=89.53 E-value=0.16 Score=51.20 Aligned_cols=44 Identities=36% Similarity=0.593 Sum_probs=41.1 Template_Neff=2.400 Q sp|P0DTC2|SPIK 1161 SPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELG 1204 (1273) Q Consensus 1161 spdvdlgdisginasvvniqkeidrlnevaknlneslidlqelg 1204 (1273) ..|+..|....||.....+.-|+.||.++.|+||||.|||.|+| T Consensus 90 eAd~~~gsl~~~n~t~ldl~yem~~~~~~~k~l~~syi~lke~g 133 (133) T 5ZUV_A 90 QSGGRGGSLDQINVTFLDLEYEMKKLEEAIKKLEESYIDLKELG 133 (133) T ss_dssp SCCCCSCCCCCCCCCCCCCHHHHHHHHHHHHHHTTCCCCHHHHC T ss_pred HhhhccCccccceeeeHHHHHHHHHHHHHHHHHHHhhcchHhhC Confidence 45788899999999999999999999999999999999999987 No 78 >6MAR_D Immunoglobulin G PGT151 Fab, Heavy; Fusion protein-Fab complex, MEMBRANE PROTEIN; HET: NAG, MAN, GAL, FUC, BMA;{Homo sapiens} Probab=71.20 E-value=3 Score=42.93 Aligned_cols=29 Identities=34% Similarity=0.603 Sum_probs=12.5 Template_Neff=7.100 Q sp|P0DTC2|SPIK 1199 DLQELGKYEQYIKW-PWYIWLGFIAGLIAI 1227 (1273) Q Consensus 1199 dlqelgkyeqyikw-pwyiwlgfiagliai 1227 (1273) |+++|.+.+....| +|-.|++.|..++.+ T Consensus 154 ~l~~l~~~~~l~~wf~~~~wl~~iki~i~i 183 (220) T 6MAR_D 154 DLLALDKWASLWNWFDISNWLWYIKIFIMI 183 (220) T ss_pred HHHhhHHHHHHHHhcChHHHHHHHHHHHHH Confidence 44444444444333 334444444433333 No 79 >6DCQ_D Envelope glycoprotein gp160, Immunoglobulin G; HIV-1, Glycoprotein, Env, VIRAL PROTEIN; HET: NAG, GAL, BMA, FUC, MAN;{Human immunodeficiency virus 1} Probab=68.19 E-value=3.9 Score=45.14 Aligned_cols=49 Identities=29% Similarity=0.335 Sum_probs=25.2 Template_Neff=6.700 Q sp|P0DTC2|SPIK 1197 LIDLQELGKYEQYIKW-PWYIWLGFIAGLIAIVMVTIMLCCMTSCCSCLK 1245 (1273) Q Consensus 1197 lidlqelgkyeqyikw-pwyiwlgfiagliaivmvtimlccmtsccsclk 1245 (1273) ..|++++.+......| .+..|++.|-.+|.||+..|.|-|+..|.+|.. T Consensus 146 ~~~l~~l~~w~~~~~wf~i~~wl~yiki~i~iv~gli~lri~~~~~~~~~ 195 (352) T 6DCQ_D 146 EKDLLALDKWTNLWNWFGISNWLWYIRIFIMIVGGLIGLRIIFAVLSVIN 195 (352) T ss_pred HHHHHHhHhhhhhHhhhCHhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 3455555555554333 334455554444555555555655555555543 No 80 >6NIJ_B PGT145 Fab heavy chain, PGT145; HIV-1, antibody, glycoprotein, IMMUNE SYSTEM; HET: NAG, BMA; 5.7A {Homo sapiens} Probab=68.17 E-value=3.9 Score=44.93 Aligned_cols=51 Identities=27% Similarity=0.312 Sum_probs=26.1 Template_Neff=6.800 Q sp|P0DTC2|SPIK 1197 LIDLQELGKYEQYIKW-PWYIWLGFIAGLIAIVMVTIMLCCMTSCCSCLKGC 1247 (1273) Q Consensus 1197 lidlqelgkyeqyikw-pwyiwlgfiagliaivmvtimlccmtsccsclkgc 1247 (1273) ..|++++.+......| .|..|++.|-.++.||+..|.|-|+..|.+|...+ T Consensus 146 ~~~l~~l~~w~~~~~wf~i~~w~~yiki~i~iv~gli~lrii~~~~~~~~~~ 197 (345) T 6NIJ_B 146 EQELLELDKWASLWNWFDITKWLWYIKIFIMIVGGLIGLRIVFTVLSIVNRI 197 (345) T ss_pred HHHHHHHHHhhhHHhhcChhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 3455555555554443 34445555544555555556666655555554443 No 81 >1WDF_B E2 glycoprotein; MHV, coronavirus, heptad repeat, fusion; 2.5A {Murine hepatitis virus} SCOP: h.3.3.1 Probab=63.13 E-value=5.7 Score=39.08 Aligned_cols=56 Identities=27% Similarity=0.481 Sum_probs=44.4 Template_Neff=2.400 Q sp|P0DTC2|SPIK 1144 ELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQE 1202 (1273) Q Consensus 1144 eldsfkeeldkyfknhtspdvdlgdisginasvvniqkeidrlnevaknlneslidlqe 1202 (1273) .|......|.+-|..-.|. +.|...||.....+--|+.|+..+.|.||||.|||.| T Consensus 40 AL~~Lt~QL~~NFgAISSs---i~d~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 95 (95) T 1WDF_B 40 ALNNLLNQLSNRFGAISDL---SLDFEKLNVTLLDLTYEMNRIQDAIKKLNESYINLKE 95 (95) T ss_dssp HHHHHHHHHHHHTCC--CC---CCCGGGCCCCCCCCHHHHHHHHHHHHHHHTTCCCTTC T ss_pred HHHHHHHHHHHhHchHHHH---HHHHHHHchHHHHHHHHHHHHHHHHHHHHHHhhcccC Confidence 4555666777777666553 5667788999999999999999999999999999975 No 82 >6GY6_C XaxA, XaxB; bacterial toxin, pore forming-toxins, TOXIN; 4.0A {Xenorhabdus nematophila ATCC 19061} Probab=57.97 E-value=8.2 Score=41.00 Aligned_cols=24 Identities=17% Similarity=0.426 Sum_probs=14.9 Template_Neff=9.300 Q sp|P0DTC2|SPIK 1172 INASVVNIQKEIDRLNEVAKNLNE 1195 (1273) Q Consensus 1172 inasvvniqkeidrlnevaknlne 1195 (1273) +++.+..++++|++|++-.+.++. T Consensus 232 l~~~i~~L~~~I~~l~~~I~~~~~ 255 (424) T 6GY6_C 232 LSTTIKDLQSKIDEKNKEIDQFQK 255 (424) T ss_pred chHHHHHHHHHHHHHHHHHHHHHH Confidence 355666777777777666555443 No 83 >6OJ7_A Fusion glycoprotein F0; Fusion protein, fusion inhibitor, six-helix; 1.45A {N/A} Probab=57.49 E-value=8.5 Score=34.15 Aligned_cols=29 Identities=17% Similarity=0.297 Sum_probs=22.5 Template_Neff=4.500 Q sp|P0DTC2|SPIK 927 FNSAIGKIQDSLSSTASALGKLQDVVNQN 955 (1273) Q Consensus 927 fnsaigkiqdslsstasalgklqdvvnqn 955 (1273) =|.|+.+++++++.++-|+.++||.+|.+ T Consensus 17 TNeAV~~L~~g~~~l~~Av~~iQd~IN~~ 45 (53) T 6OJ7_A 17 TNKAVVSLSNGVSVLTSKVLDLKNYIDKQ 45 (53) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHhhh Confidence 36778888888888888888888877753 No 84 >1G2C_W TWO HEPTAD REPEATS OF HRSV; membrane fusion, pneumovirus, HRSV, Viral; 2.3A {Human respiratory syncytial virus} SCOP: h.3.2.1 Probab=57.47 E-value=8.5 Score=34.10 Aligned_cols=29 Identities=17% Similarity=0.297 Sum_probs=22.4 Template_Neff=4.400 Q sp|P0DTC2|SPIK 927 FNSAIGKIQDSLSSTASALGKLQDVVNQN 955 (1273) Q Consensus 927 fnsaigkiqdslsstasalgklqdvvnqn 955 (1273) =|.|+.+++++++.++-|+.++||.+|.+ T Consensus 17 TNeAV~~L~~g~~~~~~Av~~iQd~IN~~ 45 (52) T 1G2C_W 17 TNKAVVSLSNGVSVLTSKVLDLKNYIDKQ 45 (52) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHCCCCC T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHhhh Confidence 46778888888888888888888877753 No 85 >6NYX_H Fusion glycoprotein F0; Fusion protein, fusion inhibitor, six-helix; HET: PEG, PG4; 1.85A {N/A} Probab=57.31 E-value=8.6 Score=34.12 Aligned_cols=29 Identities=31% Similarity=0.434 Sum_probs=23.7 Template_Neff=4.500 Q sp|P0DTC2|SPIK 927 FNSAIGKIQDSLSSTASALGKLQDVVNQN 955 (1273) Q Consensus 927 fnsaigkiqdslsstasalgklqdvvnqn 955 (1273) =|.|+.+++++++.++-|+.++||.+|.+ T Consensus 17 TNeAV~~l~~g~~~~~~Av~~iQd~IN~~ 45 (53) T 6NYX_H 17 TNKAVQSVQSSIGNLIVAIKSVQDYVNKE 45 (53) T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHh Confidence 47788888888888888888888888754 No 86 >6O40_A Fusion glycoprotein F0; Fusion protein, fusion inhibitor, six-helix; 1.2A {N/A} Probab=57.31 E-value=8.6 Score=34.12 Aligned_cols=29 Identities=31% Similarity=0.434 Sum_probs=23.7 Template_Neff=4.500 Q sp|P0DTC2|SPIK 927 FNSAIGKIQDSLSSTASALGKLQDVVNQN 955 (1273) Q Consensus 927 fnsaigkiqdslsstasalgklqdvvnqn 955 (1273) =|.|+.+++++++.++-|+.++||.+|.+ T Consensus 17 TNeAV~~l~~g~~~~~~Av~~iQd~IN~~ 45 (53) T 6O40_A 17 TNKAVQSVQSSIGNLIVAIKSVQDYVNKE 45 (53) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHCCCC T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHh Confidence 47788888888888888888888888754 No 87 >6GY8_A XaxA; bacterial toxin, pore forming-toxins, TOXIN; 2.5A {Xenorhabdus nematophila (strain ATCC 19061 / DSM 3370 / LMG 1036 / NCIB 9965 / AN6)} Probab=54.96 E-value=10 Score=39.70 Aligned_cols=22 Identities=18% Similarity=0.404 Sum_probs=13.4 Template_Neff=9.700 Q sp|P0DTC2|SPIK 1173 NASVVNIQKEIDRLNEVAKNLN 1194 (1273) Q Consensus 1173 nasvvniqkeidrlnevaknln 1194 (1273) ++.+..++++|++|++-.+.++ T Consensus 233 ~~~i~~L~~~I~~l~~~I~~~~ 254 (408) T 6GY8_A 233 STTIKDLQSKIDEKNKEIDQFQ 254 (408) T ss_dssp HHHHHHHHHHHHHHHHHHHHHH T ss_pred hHHHHHHHHHHHHHHHHHHHHH Confidence 5556666777776666555443 No 88 >6PWU_E Envelope glycoprotein gp160, Antibody PG16; HIV-1, ENV, VIRAL PROTEIN; HET: NAG, MAN, BMA, FUC, GAL;{Human immunodeficiency virus 1} Probab=52.04 E-value=12 Score=46.57 Aligned_cols=53 Identities=26% Similarity=0.308 Sum_probs=30.8 Template_Neff=5.500 Q sp|P0DTC2|SPIK 1196 SLIDLQELGKYEQYIKW-PWYIWLGFIAGLIAIVMVTIMLCCMTSCCSCLKGCC 1248 (1273) Q Consensus 1196 slidlqelgkyeqyikw-pwyiwlgfiagliaivmvtimlccmtsccsclkgcc 1248 (1273) ...||++|.+....-.| .|-.|++.|-.+|.|+...|.|-++..|+++...++ T Consensus 651 nek~l~~Ld~w~~l~~Wf~it~Wl~yIKi~i~Iv~gliglrii~~v~~~v~~~r 704 (858) T 6PWU_E 651 NEQELLELDKWANLWNWFDISNWLWYIKIFIMIVGGLIGLRIVFAVLSVINRVR 704 (858) T ss_pred HHHHHHchHHHHHHHHhhcHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHh Confidence 34566667666665444 344566666666666666666666666666554443 No 89 >3EUH_B Chromosome partition protein mukF, MukE; Chromosome condensation, condensin, non-SMC subunit; HET: GLY; 2.9A {Escherichia coli} Probab=52.03 E-value=12 Score=44.15 Aligned_cols=126 Identities=22% Similarity=0.336 Sum_probs=81.9 Template_Neff=3.500 Q sp|P0DTC2|SPIK 858 LTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLI--------ANQFNS 929 (1273) Q Consensus 858 ltvlpplltdemiaqytsallagtitsgwtfgagaalqipfamqmayrfngigvtqnvlyenqkli--------anqfns 929 (1273) |+++-..+.+|+-.-..+| ..|.-...|--..-+-|.+ -.+--|.||-.+|.++-|.|..+ ...+.+ T Consensus 125 LS~~l~~va~eL~~a~~aA-~e~~~e~~W~~~V~apLky----SV~ei~d~Id~~QR~mDeqq~~vk~eIa~LL~qDW~~ 199 (440) T 3EUH_B 125 LSMQLSIVAGELKRAADAA-EEGGDEFHWHRNVYAPLKY----SVAEIFDSIDLTQRLMDEQQQQVKDDIAQLLNKDWRA 199 (440) T ss_dssp HHHHHHHHHHHHHHHHHHH-HTCCCHHHHCCCCCHCCCC----CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHGGG T ss_pred HHHHHHHHHHHHHHHHHHH-HhcCCHHHHHhhccccccc----cHHHHHHhcchhHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 3344444455554444444 3333455676665555544 44567899999999999988543 345667 Q sp|P0DTC2|SPIK 930 AIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSS------NFGAISSVLNDILSRLDKVE 988 (1273) Q Consensus 930 aigkiqdslsstasalgklqdvvnqnaqalntlvkqlss------nfgaissvlndilsrldkve 988 (1273) ||..-+.-|+.|++.|..|||.+......|.++...+.+ ....+..++-++..+||.+. T Consensus 200 AI~~Ce~LL~eTs~tLrELqdtL~aagd~lq~~Ll~IQ~~~~~~~~l~~v~~~~~~Lq~kLDrI~ 264 (440) T 3EUH_B 200 AISSCELLLSETSGTLRELQDTLEAAGDKLQANLLRIQDATMTHDDLHFVDRLVFDLQSKLDRII 264 (440) T ss_dssp GHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHSCSCGGGHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHcCCcchHHHHHHHHHHHHHHHHHH Confidence 888999999999999999999999888777766655432 22224445555555555544 No 90 >3MAW_A Fusion glycoprotein F0; Fusion protein, class I, paramyxovirus; HET: NAG, NDG; 3.5A {Newcastle disease virus} Probab=50.68 E-value=13 Score=43.97 Aligned_cols=76 Identities=29% Similarity=0.351 Sum_probs=26.5 Template_Neff=4.900 Q sp|P0DTC2|SPIK 875 SALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQ 954 (1273) Q Consensus 875 sallagtitsgwtfgagaalqipfamqmayrfngigvtqnvlyenqklianqfnsaigkiqdslsstasalgklqdvvnq 954 (1273) ..-++|.+..|-.+|.+.|.||--|..+.--.. -.++++ .-|.-...=|.|+.++++.++.++.|+.++||-+|. T Consensus 83 ~~Rf~G~iig~~ALGVAtaaqiTA~vAl~~a~~---na~~I~--~lk~si~~TN~AV~~l~~~~~~~~~Av~~lQd~IN~ 157 (483) T 3MAW_A 83 QGRFIGAIIGSVALGVATAAQITAASALIQANQ---NAANIL--RLKESITATNEAVHEVTDGLSQLAVAVGKMQQFVND 157 (483) T ss_dssp -------------------------------CC---THHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred cceeeeehHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 345678888888888888888876544321100 001111 011112345778888888888888888888888875 Q sp|P0DTC2|SPIK 955 N 955 (1273) Q Consensus 955 n 955 (1273) + T Consensus 158 ~ 158 (483) T 3MAW_A 158 Q 158 (483) T ss_dssp H T ss_pred h Confidence 4 No 91 >6EK7_A YaxA; pathogens, pore forming toxins, alpha-helical; HET: MPD; 1.8A {Yersinia enterocolitica} Probab=49.86 E-value=14 Score=39.26 Aligned_cols=23 Identities=13% Similarity=0.316 Sum_probs=12.9 Template_Neff=9.300 Q sp|P0DTC2|SPIK 1172 INASVVNIQKEIDRLNEVAKNLN 1194 (1273) Q Consensus 1172 inasvvniqkeidrlnevaknln 1194 (1273) .+..+..++++|++|++-.+.++ T Consensus 234 ~~~~i~~L~~~I~~l~~~I~~~~ 256 (410) T 6EK7_A 234 MRKSIKELDEKIKEKRQRIEQLK 256 (410) T ss_dssp CHHHHHHHHHHHHHHHHHHHHTH T ss_pred chHHHHHHHHHHHHHHHHHHHHH Confidence 34455666666666665544443 No 92 >1SVF_C SV5 FUSION PROTEIN; PARAMYXOVIRUS, FUSION, SV5, COILED-COIL, Viral; 1.4A {Simian virus 5 (strain W3)} SCOP: h.3.2.1 Probab=49.38 E-value=14 Score=34.05 Aligned_cols=29 Identities=24% Similarity=0.340 Sum_probs=21.7 Template_Neff=4.200 Q sp|P0DTC2|SPIK 927 FNSAIGKIQDSLSSTASALGKLQDVVNQN 955 (1273) Q Consensus 927 fnsaigkiqdslsstasalgklqdvvnqn 955 (1273) =|.|+.+++++++.++.|+.++||.+|.+ T Consensus 26 TNeAV~~l~~g~~~~~~Av~~iQd~IN~~ 54 (64) T 1SVF_C 26 TNAAVADVVQATQSLGTAVQAVQDHINSV 54 (64) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHCCCC T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHh Confidence 46677777888888888888888877653 No 93 >1SVF_A SV5 FUSION PROTEIN; PARAMYXOVIRUS, FUSION, SV5, COILED-COIL, Viral; 1.4A {Simian virus 5 (strain W3)} SCOP: h.3.2.1 Probab=49.38 E-value=14 Score=34.05 Aligned_cols=29 Identities=24% Similarity=0.340 Sum_probs=21.7 Template_Neff=4.200 Q sp|P0DTC2|SPIK 927 FNSAIGKIQDSLSSTASALGKLQDVVNQN 955 (1273) Q Consensus 927 fnsaigkiqdslsstasalgklqdvvnqn 955 (1273) =|.|+.+++++++.++.|+.++||.+|.+ T Consensus 26 TNeAV~~l~~g~~~~~~Av~~iQd~IN~~ 54 (64) T 1SVF_A 26 TNAAVADVVQATQSLGTAVQAVQDHINSV 54 (64) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHCCCC T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHh Confidence 46677777888888888888888877653 No 94 >2FYZ_E Fusion glycoprotein F0; Mumps virus fusion protein core; 2.2A {Mumps virus} Probab=48.54 E-value=15 Score=33.83 Aligned_cols=29 Identities=24% Similarity=0.274 Sum_probs=22.0 Template_Neff=4.200 Q sp|P0DTC2|SPIK 927 FNSAIGKIQDSLSSTASALGKLQDVVNQN 955 (1273) Q Consensus 927 fnsaigkiqdslsstasalgklqdvvnqn 955 (1273) =|.|+.+++++++.++-|+.++||.+|.+ T Consensus 29 TNeAV~~l~~g~~~~~~Av~~iQd~IN~~ 57 (63) T 2FYZ_E 29 TNRAVFEVKEGTQRLAIAVQAIQDHINTI 57 (63) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHTTT T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHh Confidence 46777788888888888888888877753 No 95 >2B9B_B Parainfluenza Virus 5 F Protein; fusion protein, pre-fusion conformation, VIRAL; HET: NAG; 2.85A {Simian virus 5} Probab=48.31 E-value=15 Score=43.73 Aligned_cols=76 Identities=21% Similarity=0.253 Sum_probs=40.5 Template_Neff=4.600 Q sp|P0DTC2|SPIK 875 SALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQ 954 (1273) Q Consensus 875 sallagtitsgwtfgagaalqipfamqmayrfngigvtqnvlyenqklianqfnsaigkiqdslsstasalgklqdvvnq 954 (1273) ..-++|.+..|-.+|.+.|.||--|..+.--.. -.++++ .-|.-...=|.|+.++++.++.++-|+.++||-+|. T Consensus 79 ~~Rf~G~iig~~ALGVATaAqiTA~vAL~~a~~---na~~I~--~lk~si~~TN~AV~~l~~~~~~~~~Av~~iQd~IN~ 153 (497) T 2B9B_B 79 RRRFAGVVIGLAALGVATAAQVTAAVALVKANE---NAAAIL--NLKNAIQKTNAAVADVVQATQSLGTAVQAVQDHINS 153 (497) T ss_dssp --CCCSCCCCGGGGCEEEHHHHHHHHHHHHHHH---HHHHHT--TSHHHHHHSCCSECEEE--------EECSSHHHHHH T ss_pred chhhHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 445788888888999998888876554321100 001110 001112245778888899999999999999988875 Q sp|P0DTC2|SPIK 955 N 955 (1273) Q Consensus 955 n 955 (1273) + T Consensus 154 ~ 154 (497) T 2B9B_B 154 V 154 (497) T ss_dssp H T ss_pred c Confidence 4 No 96 >5YZC_B glycoprotein F2, glycoprotein F1,measles virus; glycoprotein, viral protein, fusion protein; HET: NAG, 95C; 2.334A {Measles virus (strain Ichinose-B95a)} Probab=47.22 E-value=16 Score=42.71 Aligned_cols=73 Identities=23% Similarity=0.281 Sum_probs=47.9 Template_Neff=4.700 Q sp|P0DTC2|SPIK 878 LAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQN 955 (1273) Q Consensus 878 lagtitsgwtfgagaalqipfamqmayrfngigvtqnvlyenqklianqfnsaigkiqdslsstasalgklqdvvnqn 955 (1273) ++|.|..+..+|.+.|.||--|..+.--- --.++++ .-|.-...=|.|+.++++.++.++.|+.++||-+|.+ T Consensus 1 ~~g~~ig~~algvataaqita~~al~~a~---~na~~i~--~lk~si~~tn~AV~~L~~g~~~~~~AV~~lQd~IN~~ 73 (419) T 5YZC_B 1 FAGVVLAGAALGVATAAQITAGIALHQSM---LNSQAID--NLRASLETTNQAIEAIRQAGQEMILAVQGVQDYINNE 73 (419) T ss_dssp --CEEECHHHHCCCCHHHHHHHHHHHHHS---CCHHHHH--HHHHHHHTCCCSEEEECCTTSCCEEEEETTHHHCCCC T ss_pred ChhHHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHh Confidence 46778888889988888887655432110 0011111 1111223458899999999999999999999999854 No 97 >1T98_B Chromosome partition protein mukF; WINGED HELIX, HELIX-TURN HELIX, DOMAIN; HET: MSE; 2.9A {Escherichia coli} SCOP: a.47.6.1, a.4.5.65 Probab=46.81 E-value=16 Score=41.26 Aligned_cols=104 Identities=23% Similarity=0.322 Sum_probs=67.4 Template_Neff=3.500 Q sp|P0DTC2|SPIK 858 LTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIAN--------QFNS 929 (1273) Q Consensus 858 ltvlpplltdemiaqytsallagtitsgwtfgagaalqipfamqmayrfngigvtqnvlyenqklian--------qfns 929 (1273) |+++-..+.+|+-.-..+|. .|.=-..|--..-|-|.+ -.+--|.||..+|-++-|.|..+.+ .+.+ T Consensus 125 LS~ql~~va~eL~~a~~AA~-e~gde~~W~~~V~apLky----SV~eifd~Id~~QR~mDeqQ~~vk~eIA~LL~~DW~~ 199 (287) T 1T98_B 125 LSMQLSIVAGELKRAADAAE-EGGDEFHWHRNVYAPLKY----SVAEIFDSIDLTQRLMDEQQQQVKDDIAQLLNKDWRA 199 (287) T ss_dssp HHHHHHHHHHHHHHHHHHHH-SCCSHHHHCCCCCHCCCC----CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHTC----- T ss_pred HHHHHHHHHHHHHHHHHHHH-hcCCHHHHHhhccccccc----cHHHHHHhcchHHHHHHHHHHHHHHHHHHHHCccHHH Confidence 34444445555444434443 333345676665555544 3456789999999999999865443 3457 Q sp|P0DTC2|SPIK 930 AIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQL 966 (1273) Q Consensus 930 aigkiqdslsstasalgklqdvvnqnaqalntlvkql 966 (1273) ||..-+.-|+.|++.|..|||........|.++...+ T Consensus 200 AI~~Ce~LL~eTs~tLrELqdtL~aagd~lq~~Ll~I 236 (287) T 1T98_B 200 AISSCELLLSETSGTLRELQDTLEAAGDKLQANLLRI 236 (287) T ss_dssp -CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 8888899999999999999999887776666554443 No 98 >1T98_A Chromosome partition protein mukF; WINGED HELIX, HELIX-TURN HELIX, DOMAIN; 2.9A {Escherichia coli} SCOP: a.47.6.1, a.4.5.65 Probab=46.81 E-value=16 Score=41.26 Aligned_cols=104 Identities=23% Similarity=0.322 Sum_probs=70.3 Template_Neff=3.500 Q sp|P0DTC2|SPIK 858 LTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIAN--------QFNS 929 (1273) Q Consensus 858 ltvlpplltdemiaqytsallagtitsgwtfgagaalqipfamqmayrfngigvtqnvlyenqklian--------qfns 929 (1273) |+++-..+.+|+-.-..+|. .|.=-..|--..-|-|.+ -.+--|.||..+|-++-|.|..+.+ .+.+ T Consensus 125 LS~ql~~va~eL~~a~~AA~-e~gde~~W~~~V~apLky----SV~eifd~Id~~QR~mDeqQ~~vk~eIA~LL~~DW~~ 199 (287) T 1T98_A 125 LSMQLSIVAGELKRAADAAE-EGGDEFHWHRNVYAPLKY----SVAEIFDSIDLTQRLMDEQQQQVKDDIAQLLNKDWRA 199 (287) T ss_pred HHHHHHHHHHHHHHHHHHHH-hCCCHHHHHhhccccccc----cHHHHHHhcchhHHHHHHHHHHHHHHHHHHHcccHHH Confidence 34444445555444434443 333345676665555544 3456789999999999999865443 3457 Q sp|P0DTC2|SPIK 930 AIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQL 966 (1273) Q Consensus 930 aigkiqdslsstasalgklqdvvnqnaqalntlvkql 966 (1273) ||..-+.-|+.|++.|..|||........|.++...+ T Consensus 200 AI~~Ce~LL~eTs~tLrELqdtL~aagd~lq~~Ll~I 236 (287) T 1T98_A 200 AISSCELLLSETSGTLRELQDTLEAAGDKLQANLLRI 236 (287) T ss_pred HHHHHHHHHHHHhhHHHHHHHHHHHhHHHHHHHHHHH Confidence 8888899999999999999999887776666554443 No 99 >1G5G_F FUSION PROTEIN; fusion protein, NDV, Newcastle disease; HET: BMA, NAG; 3.3A {Newcastle disease virus} SCOP: f.12.1.1, h.3.2.1 Probab=45.56 E-value=18 Score=42.92 Aligned_cols=76 Identities=30% Similarity=0.372 Sum_probs=15.9 Template_Neff=4.900 Q sp|P0DTC2|SPIK 875 SALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQ 954 (1273) Q Consensus 875 sallagtitsgwtfgagaalqipfamqmayrfngigvtqnvlyenqklianqfnsaigkiqdslsstasalgklqdvvnq 954 (1273) ..-++|.+..|-.+|.+.|.||--|..+.--.. -.++++ .-|.-...=|.|+.++++.++.++-|+.++||-+|. T Consensus 83 ~~Rf~G~iig~~ALGVAtaAqiTA~vAl~~a~~---na~~I~--~lk~si~~TN~AV~~l~~~~~~~~~Av~~iQd~IN~ 157 (481) T 1G5G_F 83 QGRLIGAIIGGVALGVATAAQITAASALIQANQ---NAANIL--RLKESIAATNEAVHEVTNGLSQLAVAVGKMQQFVND 157 (481) T ss_dssp --------------------------------------------------------------CHHHHHHHHHHHHHHHHH T ss_pred cceehhhHHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 345678888888889888888876544321100 001110 011112234778888888888888888888888875 Q sp|P0DTC2|SPIK 955 N 955 (1273) Q Consensus 955 n 955 (1273) + T Consensus 158 ~ 158 (481) T 1G5G_F 158 Q 158 (481) T ss_dssp H T ss_pred h Confidence 4 No 100 >5EVM_F Fusion glycoprotein F0; fusion protein, Nipah, prefusion, paramyxovirus; HET: MAN, NAG, MLI, BMA; 3.367A {Nipah virus} Probab=45.38 E-value=18 Score=43.38 Aligned_cols=76 Identities=29% Similarity=0.344 Sum_probs=44.9 Template_Neff=4.700 Q sp|P0DTC2|SPIK 875 SALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQ 954 (1273) Q Consensus 875 sallagtitsgwtfgagaalqipfamqmayrfngigvtqnvlyenqklianqfnsaigkiqdslsstasalgklqdvvnq 954 (1273) ..-++|.+..|-.+|.+.|.||--|..+.--.. -.+++. .-|.-...=|.|+.++++.++.++.|+.++||-+|. T Consensus 107 ~~RF~G~vig~vaLGVATaAqiTA~vAL~~a~~---na~~I~--~lk~si~~TN~AV~~l~~~~~~~~~Avq~iQd~IN~ 181 (529) T 5EVM_F 107 DVRLAGVIMAGVAIGIATAAQITAGVALYEAMK---NADNIN--KLKSSIESTNEAVVKLQETAEKTVYVLTALQDYINT 181 (529) T ss_dssp ------EEEEHHHHCSEEHHHHHHHHHHHHHHH---HHHHHH--TTHHHHHHCCSSEEECCCSSSSCCEEEETTHHHCCC T ss_pred ChhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 345678888888899888888876554432110 001110 011112345788888888999999999999988876 Q sp|P0DTC2|SPIK 955 N 955 (1273) Q Consensus 955 n 955 (1273) + T Consensus 182 ~ 182 (529) T 5EVM_F 182 N 182 (529) T ss_dssp C T ss_pred c Confidence 4 No 101 >6T3F_F Fusion glycoprotein F0, Fab66 light; Fusion Protein, Glycoprotein, Antibody, Fab; HET: NAG; 3.2A {Nipah virus} Probab=42.88 E-value=21 Score=42.66 Aligned_cols=76 Identities=29% Similarity=0.344 Sum_probs=49.9 Template_Neff=4.700 Q sp|P0DTC2|SPIK 875 SALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQ 954 (1273) Q Consensus 875 sallagtitsgwtfgagaalqipfamqmayrfngigvtqnvlyenqklianqfnsaigkiqdslsstasalgklqdvvnq 954 (1273) ..-++|.+..|-.+|.+.|.||--|..+.--.. -.+++. .-|.-...=|.|+.++++.++.++.|+.++||-+|. T Consensus 85 ~~Rf~G~iig~~ALGVAtaAqiTAgvAL~~a~~---na~~I~--~lk~si~~TN~AV~~l~~g~~~~~~Avq~iQd~IN~ 159 (502) T 6T3F_F 85 DVRLAGVIMAGVAIGIATAAQITAGVALYEAMK---NADNIN--KLKSSIESTNEAVVKLQETAEKTVYVLTALQDYINT 159 (502) T ss_dssp CSSCCSCEECHHHHCSCCHHHHHHHHHHHHHHH---HHHHHH--TTHHHHHHCCSSEEEECSSSSSCEEEEETTHHHCCC T ss_pred ChhHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 445678888888888888888876544321100 011111 011112345889999999999999999999999886 Q sp|P0DTC2|SPIK 955 N 955 (1273) Q Consensus 955 n 955 (1273) + T Consensus 160 ~ 160 (502) T 6T3F_F 160 N 160 (502) T ss_dssp C T ss_pred c Confidence 4 No 102 >3N27_B Fusion glycoprotein F0, linker, Fusion; Fusion protein, Chimera protein, fusion; HET: CIT, TBU; 1.8A {Hendravirus, Nipahvirus} Probab=42.74 E-value=21 Score=34.63 Aligned_cols=28 Identities=32% Similarity=0.335 Sum_probs=18.2 Template_Neff=2.800 Q sp|P0DTC2|SPIK 927 FNSAIGKIQDSLSSTASALGKLQDVVNQ 954 (1273) Q Consensus 927 fnsaigkiqdslsstasalgklqdvvnq 954 (1273) -|.|+.+++++++.++-|+.++||.+|. T Consensus 18 TNeAV~eL~~gl~q~avAIqaIQd~IN~ 45 (80) T 3N27_B 18 TNEAVVKLQETAEKTVYVLTALQDYSGG 45 (80) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHSSS T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHhcC Confidence 3556666666666666666666666654 No 103 >1ZTM_C Fusion glycoprotein; fusion protein, 6-helix bundle,trimer, post-fusion; HET: NAG; 3.05A {Human parainfluenza virus 3} Probab=42.53 E-value=21 Score=42.44 Aligned_cols=75 Identities=20% Similarity=0.251 Sum_probs=29.7 Template_Neff=4.800 Q sp|P0DTC2|SPIK 876 ALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQN 955 (1273) Q Consensus 876 allagtitsgwtfgagaalqipfamqmayrfngigvtqnvlyenqklianqfnsaigkiqdslsstasalgklqdvvnqn 955 (1273) .-++|.|..|-.+|.+.|.||--|..+.-.- --.++++ .-|.-...=|.|+.++++.++.++.|+.++||-+|.+ T Consensus 90 ~r~~g~iig~~algvataaqita~~al~~a~---~na~~i~--~lk~si~~tn~AV~~L~~g~~~~~~Avq~iQd~IN~~ 164 (490) T 1ZTM_C 90 KRFFGGVIGTIALGVATSAQITAAVALVEAK---QARSDIE--KLKEAIRDTNKAVQSVQSSIGNLIVAIKSVQDYVNKE 164 (490) T ss_dssp ----------------------------CCC---CCCSHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC T ss_pred ccchhHHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhc Confidence 3467778888888888888887654432110 0011111 1122223458899999999999999999999998864 No 104 >4GIP_D Fusion glycoprotein F2, Fusion glycoprotein; PIV5, viral fusion protein, membrane; HET: NAG; 2.0A {Simian virus 5} Probab=42.00 E-value=22 Score=41.54 Aligned_cols=72 Identities=22% Similarity=0.278 Sum_probs=47.3 Template_Neff=4.800 Q sp|P0DTC2|SPIK 878 LAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVL-YENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQN 955 (1273) Q Consensus 878 lagtitsgwtfgagaalqipfamqmayrfngigvtqnvl-yenqklianqfnsaigkiqdslsstasalgklqdvvnqn 955 (1273) ++|.+..|..+|.+.|.||--|..+.- ..||.- ...-|.-...=|.|+.++++.++.++.|+.++||-+|.+ T Consensus 1 ~~g~~ig~~algvataaqita~~al~~------a~~na~~i~~lk~si~~tn~AV~~L~~g~~~~~~Av~~lQd~IN~~ 73 (409) T 4GIP_D 1 FAGVVIGLAALGVATAAQVTAAVALVK------ANENAAAILNLKNAIQKTNAAVADVVQATQSLGTAVQAVQDHINSV 73 (409) T ss_dssp CCSCEECGGGGCEEEHHHHHHHHHHHH------THHHHHHHHTTHHHHHHCCCSEEEEEETTEEEEEEECTTHHHHHHH T ss_pred CchHHHHHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHc Confidence 467888888899888888876554321 111110 000111223457889999999999999999999988754 No 105 >6H2E_Q AhlB; Tripartite pore-forming toxin, TOXIN; 2.35A {Aeromonas hydrophila} Probab=41.72 E-value=22 Score=35.49 Aligned_cols=23 Identities=22% Similarity=0.426 Sum_probs=11.9 Template_Neff=9.500 Q sp|P0DTC2|SPIK 1173 NASVVNIQKEIDRLNEVAKNLNE 1195 (1273) Q Consensus 1173 nasvvniqkeidrlnevaknlne 1195 (1273) +..+..++++|++|++-.+.++. T Consensus 128 ~~~i~~l~~~I~~l~~~i~~~~~ 150 (274) T 6H2E_Q 128 QATIAGLQSNLDGARQELDSLNK 150 (274) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHHHHHH Confidence 34445555556555555544444 No 106 >5IJO_G Nuclear pore complex protein Nup155; Nuclear pore complex, Nucleocytoplasmic transport; 21.4A {Homo sapiens} Probab=40.35 E-value=24 Score=42.67 Aligned_cols=55 Identities=18% Similarity=0.345 Sum_probs=33.8 Template_Neff=5.300 Q sp|P0DTC2|SPIK 1133 VNNTVYDPLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEV 1189 (1273) Q Consensus 1133 vnntvydplqpeldsfkeeldkyfknhtspdvdlgdisginasvvniqkeidrlnev 1189 (1273) ..++-|+.|.+|+....|+||||+|....-.-++...+. ..+.+|+++|++|... T Consensus 239 sk~~K~~dLP~eIqk~VE~LdkfIK~QkqisdEIsr~Ss--~~l~kV~~DIe~L~q~ 293 (599) T 5IJO_G 239 SKALKDENLPPVICQDVENLQKFVKEQKQVQEEISRMSS--KAMLKVQEDIKALKQL 293 (599) T ss_dssp ---------CHHHHHHHHHHHHHHHHHHHHHHHHHHHCC--SHHHHHHHHHHHHHHH T ss_pred chhhhhccCCHHHHHHHHHHHHHHHHHHHHHHHHHhcCH--HHHHHHHHHHHHHHHH Confidence 346778888889988899999999988776666665553 3466777777766543 No 107 >1WP7_A fusion protein; Nipah Virus, Fusion Core, heptad; 2.2A {Nipah virus} Probab=40.33 E-value=24 Score=34.77 Aligned_cols=28 Identities=32% Similarity=0.322 Sum_probs=18.7 Template_Neff=2.700 Q sp|P0DTC2|SPIK 927 FNSAIGKIQDSLSSTASALGKLQDVVNQ 954 (1273) Q Consensus 927 fnsaigkiqdslsstasalgklqdvvnq 954 (1273) -|.|+.+++++++.++-|+.++||-+|. T Consensus 18 TNeAV~eL~~gl~qtavAIqaIQD~IN~ 45 (89) T 1WP7_A 18 TNEAVVKLQETAEKTVYVLTALQDYGGS 45 (89) T ss_dssp HHHHHHHHHHHHHHHHHHHHHCCC---- T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHccC Confidence 4677777888888888888888877763 No 108 >1WP8_C fusion; Hendra Virus, Fusion Core, heptad; 2.2A {Hendra virus} Probab=39.60 E-value=25 Score=34.65 Aligned_cols=28 Identities=32% Similarity=0.322 Sum_probs=18.4 Template_Neff=2.700 Q sp|P0DTC2|SPIK 927 FNSAIGKIQDSLSSTASALGKLQDVVNQ 954 (1273) Q Consensus 927 fnsaigkiqdslsstasalgklqdvvnq 954 (1273) -|.|+.+++++++.++-|+.++||-+|. T Consensus 18 TNeAV~eL~~gl~qtavAIqaIQD~IN~ 45 (89) T 1WP8_C 18 TNEAVVKLQETAEKTVYVLTALQDYGGS 45 (89) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHTC---- T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHccC Confidence 4667777777777777777777777763 No 109 >6R1J_J AhlB; Tripartite pore-forming toxin, TOXIN; 1.92A {Aeromonas hydrophila J-1} Probab=39.16 E-value=26 Score=34.77 Aligned_cols=24 Identities=21% Similarity=0.447 Sum_probs=12.5 Template_Neff=9.700 Q sp|P0DTC2|SPIK 1172 INASVVNIQKEIDRLNEVAKNLNE 1195 (1273) Q Consensus 1172 inasvvniqkeidrlnevaknlne 1195 (1273) ++..+..++++|+.|++-.+.++. T Consensus 127 ~~~~i~~l~~~I~~l~~~I~~~~~ 150 (272) T 6R1J_J 127 LQATIAGLQSNLDGARQELDSLNK 150 (272) T ss_pred chHhHHHHHHHHHHHHHHHHHHHH Confidence 344445555566655555554444 No 110 >6C14_A Protocadherin-15, LHFPL tetraspan subfamily member; PCDH15, LHFPL5, protocadherin, tip link;{Mus musculus} Probab=38.64 E-value=27 Score=35.39 Aligned_cols=26 Identities=35% Similarity=0.680 Sum_probs=13.7 Template_Neff=10.000 Q sp|P0DTC2|SPIK 1108 NFYEPQIITTDNT--FVSGNCDVVIGIV 1133 (1273) Q Consensus 1108 nfyepqiittdnt--fvsgncdvvigiv 1133 (1273) ..|+-.+..+|+. -.+..+.|.|-++ T Consensus 82 ~~~~l~V~A~D~~~~~~~~~~~v~I~V~ 109 (337) T 6C14_A 82 SYFKFQVIATDDYGKGLSGKADVLVSVV 109 (337) T ss_dssp CCEEEEEEEEHHHHTSCEEEEEEEECEE T ss_pred CeEEEEEEEEcCCCCCCCeEEEEEEEEe Confidence 4556666667764 2334455555443 No 111 >5EJB_D Fusion glycoprotein F0; prefusion form, viral glycoprotein, ectodomain; HET: NAG, SO4; 3.2A {Hendra virus} Probab=38.02 E-value=28 Score=41.68 Aligned_cols=76 Identities=28% Similarity=0.344 Sum_probs=45.1 Template_Neff=4.700 Q sp|P0DTC2|SPIK 875 SALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQ 954 (1273) Q Consensus 875 sallagtitsgwtfgagaalqipfamqmayrfngigvtqnvlyenqklianqfnsaigkiqdslsstasalgklqdvvnq 954 (1273) ..-++|.+..|..+|.+.|.||--|..+.--.. -.+++. .-|.-...=|.|+.++++.++.++.|+.++||-+|. T Consensus 82 ~~Rf~G~iig~~AlgVAtaaqita~vAl~~a~~---na~~i~--~lk~si~~tn~AV~~L~~g~~~~~~Avq~lQd~IN~ 156 (501) T 5EJB_D 82 DVKLAGVVMAGIAIGIATAAQITAGVALYEAMK---NADNIN--KLKSSIESTNEAVVKLQETAEKTVYVLTALQDYINT 156 (501) T ss_dssp -------CEEHHHHCSEEHHHHHHHHHHHHHHH---HHHHHH--TTHHHHHTCCSSEEEEECSSSCEEEEEETTHHHCCC T ss_pred CcchHHHHHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHH--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 345678888888888888888765543321100 001111 011112345889999999999999999999999886 Q sp|P0DTC2|SPIK 955 N 955 (1273) Q Consensus 955 n 955 (1273) + T Consensus 157 ~ 157 (501) T 5EJB_D 157 N 157 (501) T ss_dssp C T ss_pred c Confidence 4 No 112 >2M8R_A Syntaxin-1A; syntaxin, SNARE, Prefusion, membrane protein; NMR {Rattus norvegicus} Probab=36.65 E-value=30 Score=29.72 Aligned_cols=12 Identities=8% Similarity=0.033 Sum_probs=5.6 Template_Neff=9.700 Q sp|P0DTC2|SPIK 1211 KWPWYIWLGFIA 1222 (1273) Q Consensus 1211 kwpwyiwlgfia 1222 (1273) +|-|++.+++++ T Consensus 84 ~~~~~~~~~~~~ 95 (109) T 2M8R_A 84 RKKIMIIICCVI 95 (109) T ss_dssp HHHHHHHHHHHH T ss_pred HHHHHHHHHHHH Confidence 355555444333 No 113 >3HD7_B Vesicle-associated membrane protein 2, Syntaxin-1A; MEMBRANE PROTEIN, COILED-COIL, 4-HELICAL BUNDLE; HET: SO4, GGG; 3.4A {Rattus norvegicus} Probab=36.65 E-value=30 Score=29.72 Aligned_cols=12 Identities=8% Similarity=0.033 Sum_probs=5.6 Template_Neff=9.700 Q sp|P0DTC2|SPIK 1211 KWPWYIWLGFIA 1222 (1273) Q Consensus 1211 kwpwyiwlgfia 1222 (1273) +|-|++.+++++ T Consensus 84 ~~~~~~~~~~~~ 95 (109) T 3HD7_B 84 RKKIMIIICCVI 95 (109) T ss_dssp HHHHHHHHHHHH T ss_pred HHHHHHHHHHHH Confidence 355555444333 No 114 >5C3L_B Nucleoporin Nup54, MGC84997 protein, Nucleoporin; nucleoporin, heterotrimeric coiled coils, kink; 2.9A {Xenopus laevis} Probab=34.34 E-value=35 Score=32.07 Aligned_cols=57 Identities=16% Similarity=0.251 Sum_probs=31.9 Template_Neff=8.500 Q sp|P0DTC2|SPIK 1131 GIVNNTVYDPLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEV 1189 (1273) Q Consensus 1131 givnntvydplqpeldsfkeeldkyfknhtspdvdlgdisginasvvniqkeidrlnev 1189 (1273) ++--+|-|+.|.|++....++|+++++....-.-++...+- ..+..+..++++|..- T Consensus 6 ~~~~~tkf~dLp~~~q~~l~~ld~~I~~q~~~~~el~~~~~--~~~~~i~~di~~l~~~ 62 (142) T 5C3L_B 6 EDSKALKDENLPQLLCQDVENFQKFVKEQKQVQEEISRMSS--KAMLKVQEDIKALKQL 62 (142) T ss_dssp ------------CCSGGGGGGGTHHHHHHHHHHHHHHHCCS--HHHHHHHHHHHHHHHH T ss_pred ccccccccccCCHHHHHHHHHHHHHHHHHHHHHHHHHhhch--HHHHHHHHHHHHHHHH Confidence 34557889999999999999999999987766655555443 3566666666655443 No 115 >5G6U_A LANGERIN; CARBOHYDRATE BINDING PROTEIN, LANGERIN, CD207; HET: TRP, CL, YJM; 1.844A {HOMO SAPIENS} Probab=32.97 E-value=38 Score=33.48 Aligned_cols=42 Identities=17% Similarity=0.467 Sum_probs=25.7 Template_Neff=9.700 Q sp|P0DTC2|SPIK 1038 KRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFP 1090 (1273) Q Consensus 1038 krvdfcgkgyhlmsfpqsaphgvvflhvtyvpaqeknfttapaichdgkahfp 1090 (1273) .....|..||.... |..| |+....++|..|-..|.+-.+|.. T Consensus 123 ~~~~~c~~~w~~~~-------~~cy----~~~~~~~tw~~A~~~C~~~g~~L~ 164 (261) T 5G6U_A 123 DILQVVSQGWKYFK-------GNFY----YFSLIPKTWYSAEQFCVSRNSHLT 164 (261) T ss_pred cccccCCCCeEEEC-------CEEE----EEEeceeCHHHHHHHHHHcCCEee Confidence 44567877776531 2211 222346788899999988766654 No 116 >3IPD_E Vesicle-associated membrane protein 2, Syntaxin-1A; MEMBRANE PROTEIN, COILED COIL, 4-HELICAL; 4.8A {Rattus norvegicus} Probab=26.85 E-value=56 Score=28.69 Aligned_cols=9 Identities=33% Similarity=0.386 Sum_probs=3.8 Template_Neff=8.400 Q sp|P0DTC2|SPIK 1212 WPWYIWLGF 1220 (1273) Q Consensus 1212 wpwyiwlgf 1220 (1273) +-|++.+++ T Consensus 68 ~k~~iii~~ 76 (91) T 3IPD_E 68 LKMMIILGV 76 (91) T ss_dssp HHHHHTTTT T ss_pred HHHHHHHHH Confidence 344444443 No 117 >3HD7_A Vesicle-associated membrane protein 2, Syntaxin-1A; MEMBRANE PROTEIN, COILED-COIL, 4-HELICAL BUNDLE; HET: SO4, GGG; 3.4A {Rattus norvegicus} Probab=26.85 E-value=56 Score=28.69 Aligned_cols=9 Identities=33% Similarity=0.386 Sum_probs=3.8 Template_Neff=8.400 Q sp|P0DTC2|SPIK 1212 WPWYIWLGF 1220 (1273) Q Consensus 1212 wpwyiwlgf 1220 (1273) +-|++.+++ T Consensus 68 ~k~~iii~~ 76 (91) T 3HD7_A 68 LKMMIILGV 76 (91) T ss_dssp HHHHHHHHH T ss_pred HHHHHHHHH Confidence 344444443 No 118 >6BP2_B Envelope Glycoprotein GP1, Envelope Glycoprotein; Marburg, Ravn, Glycoprotein, Complex, VIRAL; HET: NAG, BMA, MAN; 3.172A {Marburg marburgvirus} Probab=24.89 E-value=64 Score=35.25 Aligned_cols=40 Identities=13% Similarity=0.088 Sum_probs=26.5 Template_Neff=4.200 Q sp|P0DTC2|SPIK 925 NQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVK 964 (1273) Q Consensus 925 nqfnsaigkiqdslsstasalgklqdvvnqnaqalntlvk 964 (1273) .+....+....++++.....+..+..+|-||..||.-|.- T Consensus 122 ~~l~k~~N~Ts~ALs~L~~ql~SLr~vvLQNR~ALD~LLa 161 (202) T 6BP2_B 122 CRLRRLANQTAKSLELLLRVTTEERTFSLINRHAIDFLLT 161 (202) T ss_dssp HHHHHHHHHHHHHHHHHHHHCCCCSCCCHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHhhchhHHhHHHH Confidence 3334444445555556666666678899999999987654 No 119 >6QD8_D Light chain, Virion spike glycoprotein,EBOV-GP1; Antibody, immune response, viral infection; HET: NAG, BMA;{Homo sapiens} Probab=23.45 E-value=72 Score=33.90 Aligned_cols=34 Identities=18% Similarity=0.191 Sum_probs=21.5 Template_Neff=4.700 Q sp|P0DTC2|SPIK 931 IGKIQDSLSSTASALGKLQDVVNQNAQALNTLVK 964 (1273) Q Consensus 931 igkiqdslsstasalgklqdvvnqnaqalntlvk 964 (1273) +....++++.....+..+..+|-||..||.-|.- T Consensus 61 ~N~T~~aL~~L~~ql~Slr~vvLQNR~ALD~Ll~ 94 (168) T 6QD8_D 61 ANETTQALQLFLRATTELRTFSILNRKAIDFLLQ 94 (168) T ss_dssp HHHHHHHHHHHHHHCCCSEECCHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHHHHHhhchhHHHHHHH Confidence 3334444444445555567788999999887643 No 120 >4NJL_A S protein; six-helix-bundle, coronavirus, MERS-Cov, fusion inhibitor; HET: PGE; 2.3A {Middle East respiratory syndrome coronavirus} Probab=22.64 E-value=76 Score=33.23 Aligned_cols=27 Identities=52% Similarity=0.736 Sum_probs=14.8 Template_Neff=2.500 Q sp|P0DTC2|SPIK 1178 NIQKEIDRLNEVAKNLNESLIDLQELG 1204 (1273) Q Consensus 1178 niqkeidrlnevaknlneslidlqelg 1204 (1273) .+--|.-.+..+.|.+||+.|||.||| T Consensus 104 d~t~~~~s~~q~~~~~ne~~~~~~~~~ 130 (131) T 4NJL_A 104 DLTYEMLSLQQVVKALNESYIDLKELG 130 (131) T ss_dssp CCHHHHHHHHHHHHHHHTTCCCGGGSC T ss_pred HHHHHHhhHHHHHHHHHHhcccHHHhc Confidence 333333444555566666666666665 No 121 >4LWS_B Uncharacterized protein; ESX Secretion, Signal Sequence, Type; HET: ACT, GOL; 2.0A {Thermomonospora curvata} Probab=22.18 E-value=79 Score=26.31 Aligned_cols=32 Identities=9% Similarity=0.094 Sum_probs=19.5 Template_Neff=10.300 Q sp|P0DTC2|SPIK 955 NAQALNTLVKQLSSNFGAISSVLNDILSRLDK 986 (1273) Q Consensus 955 naqalntlvkqlssnfgaissvlndilsrldk 986 (1273) .++++..+.+++...+..+...|+++-..|.. T Consensus 54 a~~~~~~~~~~~~~~~~~~~~~l~~~~~~l~~ 85 (103) T 4LWS_B 54 AQAAYWNYQKEWDAAAKDMQNVVAQLGVAIRE 85 (103) T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 45556666666666666666666666555544 No 122 >2NRJ_A Hbl B protein; Enterotoxin Hemolysis Transmembrane; 2.03A {Bacillus cereus} SCOP: h.4.4.2 Probab=21.90 E-value=80 Score=32.38 Aligned_cols=15 Identities=20% Similarity=0.202 Sum_probs=6.3 Template_Neff=9.900 Q sp|P0DTC2|SPIK 1205 KYEQYIKWPWYIWLG 1219 (1273) Q Consensus 1205 kyeqyikwpwyiwlg 1219 (1273) +|+.++..-|++++| T Consensus 194 ~~~~~~~~~~~~~~g 208 (346) T 2NRJ_A 194 YYKQLESDGFNVMKG 208 (346) T ss_dssp GGGCCC--CCGGGTS T ss_pred HHHHHhhccchhchH Confidence 455554444544444 No 123 >2N2A_B Receptor tyrosine-protein kinase erbB-2; HER2, ErbB2, Tyrosine kinase, Activation; NMR {Homo sapiens} Probab=21.75 E-value=81 Score=26.93 Aligned_cols=23 Identities=22% Similarity=0.033 Sum_probs=13.7 Template_Neff=7.000 Q sp|P0DTC2|SPIK 1206 YEQYIKWPWYIWLGFIAGLIAIV 1228 (1273) Q Consensus 1206 yeqyikwpwyiwlgfiagliaiv 1228 (1273) |||-.+-...|+.|.++|+++++ T Consensus 1 ~~~~~~~~~~I~~~Vvg~l~~~~ 23 (58) T 2N2A_B 1 AEQRASPLTSIISAVVGILLVVV 23 (58) T ss_dssp CCCCCCHHHHHHHHHHHHHHHHH T ss_pred CCcccCChHHHHHHHHHHHHHHH Confidence 34555545557777777776443 No 124 >6F5U_B Envelope glycoprotein,GP1, Envelope glycoprotein; EBOLA VIRUS, FILOVIRIDAE, ENVELOPE GLYCOPROTEIN; HET: NAG, GOL, CQN, DMS, BMA, MAN; 2.07A {Zaire ebolavirus (strain Mayinga-76)} Probab=21.41 E-value=83 Score=33.10 Aligned_cols=38 Identities=16% Similarity=0.183 Sum_probs=24.4 Template_Neff=5.300 Q sp|P0DTC2|SPIK 927 FNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVK 964 (1273) Q Consensus 927 fnsaigkiqdslsstasalgklqdvvnqnaqalntlvk 964 (1273) ....+....++++.....+..+..+|-||..||.-|.- T Consensus 57 l~~~~n~T~~al~~L~~~l~slr~vvLQNR~aLD~Ll~ 94 (168) T 6F5U_B 57 LRQLANETTQALQLFLRATTELRTFSILNRKAIDFLLQ 94 (168) T ss_dssp HHHHHHHHHHHHHHHHHHCCCSEECCHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHhhchhHHHHHHH Confidence 33334444555555555556677889999999887653 No 125 >5F1B_B GP1, GP2, Niemann-Pick C1 protein; Ebola virus, glycoprotein, NPC1-C, VIRAL; HET: NAG; 2.3A {Zaire ebolavirus} Probab=21.40 E-value=84 Score=31.95 Aligned_cols=37 Identities=16% Similarity=0.180 Sum_probs=24.1 Template_Neff=5.300 Q sp|P0DTC2|SPIK 929 SAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQ 965 (1273) Q Consensus 929 saigkiqdslsstasalgklqdvvnqnaqalntlvkq 965 (1273) ..+....++++.....+..+..+|-||..||.-|.-+ T Consensus 52 ~~~n~t~~al~~L~~~l~sl~~vvLQNR~aLD~Ll~~ 88 (130) T 5F1B_B 52 QLANETTQALQLFLRATTELRTFSILNRKAIDFLLQR 88 (130) T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHhhhHHHHHHHHHh Confidence 3344445555555555666778889999998876543 No 126 >6HS4_B Envelope glycoprotein,Envelope glycoprotein,Envelope glycoprotein, Envelope; Ebola Glycoprotein, Structure-based In Silico; HET: BMA, GON, NAG, GOL, MAN; 2.05A {Zaire ebolavirus (strain Mayinga-76)} Probab=21.34 E-value=84 Score=33.08 Aligned_cols=40 Identities=15% Similarity=0.150 Sum_probs=25.9 Template_Neff=5.300 Q sp|P0DTC2|SPIK 925 NQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVK 964 (1273) Q Consensus 925 nqfnsaigkiqdslsstasalgklqdvvnqnaqalntlvk 964 (1273) .+....+....++++.....+..+..+|-||..||.-|.- T Consensus 55 ~~l~~~~n~t~~al~~L~~~l~sl~~vvLQNR~aLD~Ll~ 94 (168) T 6HS4_B 55 CGLRQLANETTQALQLFLRATTELRTFSILNRKAIDFLLQ 94 (168) T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHhhchhHHHHHHH Confidence 3333444445555555566666677889999999987653 No 127 >2KG7_A Uncharacterized protein esxG (PE family; Protein complex, UNKNOWN FUNCTION; NMR {Mycobacterium tuberculosis} Probab=21.11 E-value=85 Score=25.82 Aligned_cols=66 Identities=11% Similarity=0.201 Sum_probs=38.0 Template_Neff=10.300 Q sp|P0DTC2|SPIK 923 IANQFNSAIGKIQDSLSSTASALGKLQDVVN-QNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVE 988 (1273) Q Consensus 923 ianqfnsaigkiqdslsstasalgklqdvvn-qnaqalntlvkqlssnfgaissvlndilsrldkve 988 (1273) .++++.+..+.|++.++.....+..|...-. ..+.+......++...+..+...|+++-..|.+.. T Consensus 14 ~a~~~~~~~~~l~~~~~~l~~~~~~l~~~W~G~a~~af~~~~~~~~~~~~~~~~~L~~~~~~l~~~~ 80 (97) T 2KG7_A 14 SQSAFAAKAGLMRHTIGQAEQAAMSAQAFHQGESSAAFQAAHARFVAAAAKVNTLLDVAQANLGEAA 80 (97) T ss_dssp TTCHHHHHHHHHHHHHHHHHHHHHHHGGGTCSSCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHSTTC T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHhhcchHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 4555666666666666555555554432222 23445666666666666666666666666665543 No 128 >6W08_B NSP15 endoribnuclease; Tripartite pore forming toxin, Cytotoxin; HET: EDO; 1.75A {Vibrio cholerae O1 biovar El Tor str. N16961} Probab=20.88 E-value=87 Score=32.75 Aligned_cols=55 Identities=15% Similarity=0.317 Sum_probs=27.7 Template_Neff=9.500 Q sp|P0DTC2|SPIK 1139 DPLQPELDSFKEELDKYFKNHTSPDVDLGD--------ISGINASVVNIQKEIDRLNEVAKNL 1193 (1273) Q Consensus 1139 dplqpeldsfkeeldkyfknhtspdvdlgd--------isginasvvniqkeidrlnevaknl 1193 (1273) +.++.+++.|+..|..+...-..-.-++.. ..+.++.+..++++|++|++-.+.+ T Consensus 122 ~~~~~~~~~~~~~l~~f~~~~~~~~~~l~~~~~~~~~~~~~~~~~i~~L~~~I~~l~~~i~~~ 184 (359) T 6W08_B 122 QSLTSNIKRYDEGLNAWARQVEDAHNTLQQTIAQIQQEEVSIQAEIIATNAQIDLMKQQIAAF 184 (359) T ss_dssp HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCGGGHHHHHHHHHHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 456666667777666554442222222322 1334445556666666665544433 No 129 >3OGI_C Putative ESAT-6-like protein 6, Putative; Structural Genomics, PSI-2, Protein Structure; HET: MSE; 2.549A {Mycobacterium tuberculosis} Probab=20.43 E-value=90 Score=26.79 Aligned_cols=66 Identities=14% Similarity=0.137 Sum_probs=31.7 Template_Neff=9.500 Q sp|P0DTC2|SPIK 921 KLIANQFNSAIGKIQDSLSSTASALGKLQDV-VNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDK 986 (1273) Q Consensus 921 klianqfnsaigkiqdslsstasalgklqdv-vnqnaqalntlvkqlssnfgaissvlndilsrldk 986 (1273) .-.++.+....+.|++.++.....+..|.+. ....+++......++...+..+...|+++-..|+. T Consensus 11 ~~~a~~l~~~~~~l~~~~~~l~~~~~~l~~~W~G~a~~af~~~~~~~~~~~~~~~~~l~~~~~~l~~ 77 (101) T 3OGI_C 11 DAHGAMIRAQAGLLEAEHQAIVRDVLAAGDFWGGAGSVACQEFITQLGRNFQVIYEQANAHGQKVQA 77 (101) T ss_dssp --CHHHHHHHHHHHHHHHHHHHHHHHHTGGGTTCTTSHHHHHHHHHHHHHHHHHTTCC--------- T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhhccHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Confidence 3455666666666666666555555555332 22345555566666666666666666666555544 No 130 >5HJ3_L Envelope glycoprotein, KZ52 Antibody Fragment; Ebola virus, EOV, Ebolavirus, GP; HET: MAN, NAG, BMA; 3.3A {Ebola virus sp.} Probab=20.10 E-value=93 Score=31.85 Aligned_cols=35 Identities=17% Similarity=0.174 Sum_probs=23.0 Template_Neff=5.300 Q sp|P0DTC2|SPIK 930 AIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVK 964 (1273) Q Consensus 930 aigkiqdslsstasalgklqdvvnqnaqalntlvk 964 (1273) .+....++++.....+..+..+|-||..||.-|.- T Consensus 60 ~~n~t~~al~~L~~~l~sl~~vvLQNR~aLD~Lla 94 (136) T 5HJ3_L 60 LANETTQALQLFLRATTELRTFSILNRKAIDFLLQ 94 (136) T ss_pred HHHHHHHHHHHHHHHHHHHHHHHhhchHHHHHHHH Confidence 33444455555555566677888999999887653 No 131 >6RX1_A Syncytin-1; HUMAN PLACENTAL PROTEIN, MEMBRANE FUSION; 2.1A {Homo sapiens} Probab=20.03 E-value=93 Score=30.99 Aligned_cols=53 Identities=26% Similarity=0.386 Sum_probs=30.7 Template_Neff=5.000 Q sp|P0DTC2|SPIK 908 GIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVK 964 (1273) Q Consensus 908 gigvtqnvlyenqklianqfnsaigkiqdslsstasalgklqdvvnqnaqalntlvk 964 (1273) |.|+++.-+. .+..+....+....++++.....+..+..+|-||..||.-|.- T Consensus 12 ~~~~~~~~l~----~L~~~l~~~~n~t~~al~~L~~~l~sl~~vvLQNR~aLD~Ll~ 64 (108) T 6RX1_A 12 FQSTSTQFYY----KLSQELNGDMERVADSLVTLQDQLNSLAAVVLQNRRALDLLTA 64 (108) T ss_dssp ------CHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTG T ss_pred ccchhhHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHhhchhHHHHHHH Confidence 5555553222 2333444445556666777777777788899999999887653