annotate test-data/expected_single_knockout.csv @ 0:dfeabe31d865 draft default tip

planemo upload for repository https://github.com/AlmaasLab/elixir-galaxy-tools-systemsbiology commit 3f7bec1264a86e1488ee1315dbac0f44675f5171

reaction_id;ko_gene_id_1;ko_gene_id_2;reaction;wildtype_flux;knockout_flux
ACALD;b1241;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b1241;;acald_e <=> acald_c;0.0;0.0
ACKr;b1241;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b1241;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b1241;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b1241;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b1241;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b1241;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b1241;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b1241;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b1241;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b1241;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b1241;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b1241;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b1241;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b1241;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b1241;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b1241;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b1241;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b1241;;ac_e --> ;0.0;0.0
EX_acald_e;b1241;;acald_e --> ;0.0;0.0
EX_akg_e;b1241;;akg_e --> ;0.0;0.0
EX_co2_e;b1241;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b1241;;etoh_e --> ;0.0;0.0
EX_for_e;b1241;;for_e --> ;0.0;0.0
EX_fru_e;b1241;;fru_e --> ;0.0;0.0
EX_fum_e;b1241;;fum_e --> ;0.0;0.0
EX_glc__D_e;b1241;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b1241;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b1241;;glu__L_e --> ;0.0;0.0
EX_h_e;b1241;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b1241;;h2o_e <=> ;29.175827135565836;29.175827135565825
EX_lac__D_e;b1241;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b1241;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b1241;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b1241;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b1241;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b1241;;pyr_e --> ;0.0;0.0
EX_succ_e;b1241;;succ_e --> ;0.0;0.0
FBA;b1241;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b1241;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b1241;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b1241;;for_c --> for_e;0.0;0.0
FRD7;b1241;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b1241;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b1241;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b1241;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b1241;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b1241;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b1241;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b1241;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b1241;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b1241;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b1241;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b1241;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b1241;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b1241;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b1241;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565825
ICDHyr;b1241;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b1241;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b1241;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b1241;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b1241;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b1241;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b1241;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b1241;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b1241;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b1241;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b1241;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b1241;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b1241;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b1241;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b1241;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b1241;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b1241;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b1241;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b1241;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b1241;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b1241;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b1241;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b1241;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b1241;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b1241;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b1241;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b1241;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b1241;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b1241;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b1241;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b1241;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b1241;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b1241;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b1241;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b1241;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b1241;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b1241;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b0351;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b0351;;acald_e <=> acald_c;0.0;0.0
ACKr;b0351;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b0351;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b0351;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b0351;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b0351;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b0351;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b0351;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b0351;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b0351;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b0351;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b0351;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b0351;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b0351;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b0351;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b0351;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b0351;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b0351;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b0351;;ac_e --> ;0.0;0.0
EX_acald_e;b0351;;acald_e --> ;0.0;0.0
EX_akg_e;b0351;;akg_e --> ;0.0;0.0
EX_co2_e;b0351;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b0351;;etoh_e --> ;0.0;0.0
EX_for_e;b0351;;for_e --> ;0.0;0.0
EX_fru_e;b0351;;fru_e --> ;0.0;0.0
EX_fum_e;b0351;;fum_e --> ;0.0;0.0
EX_glc__D_e;b0351;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b0351;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b0351;;glu__L_e --> ;0.0;0.0
EX_h_e;b0351;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b0351;;h2o_e <=> ;29.175827135565836;29.175827135565825
EX_lac__D_e;b0351;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b0351;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b0351;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b0351;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b0351;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b0351;;pyr_e --> ;0.0;0.0
EX_succ_e;b0351;;succ_e --> ;0.0;0.0
FBA;b0351;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b0351;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b0351;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b0351;;for_c --> for_e;0.0;0.0
FRD7;b0351;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b0351;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b0351;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b0351;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b0351;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b0351;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b0351;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b0351;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b0351;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b0351;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b0351;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b0351;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b0351;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b0351;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b0351;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565825
ICDHyr;b0351;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b0351;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b0351;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b0351;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b0351;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b0351;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b0351;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b0351;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b0351;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b0351;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b0351;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b0351;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b0351;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b0351;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b0351;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b0351;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b0351;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b0351;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b0351;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b0351;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b0351;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b0351;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b0351;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b0351;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b0351;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b0351;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b0351;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b0351;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b0351;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b0351;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b0351;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b0351;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b0351;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b0351;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b0351;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b0351;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b0351;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;s0001;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;-8.472323479412339
ACALDt;s0001;;acald_e --> acald_c;0.0;0.0
ACKr;s0001;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;-8.318655312470348
ACONTa;s0001;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;0.22779965006005928
ACONTb;s0001;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;0.22779965006005928
ACt2r;s0001;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;-8.318655312470348
ADK1;s0001;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;s0001;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0
AKGt2r;s0001;;akg_e + h_e <=> akg_c + h_c;0.0;-1.447703970271745e-14
ALCD2x;s0001;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;-8.472323479412339
ATPM;s0001;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;s0001;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;-5.30330124790922
Biomass_Ecoli_core;s0001;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.21114065257211634
CO2t;s0001;;co2_e --> co2_c;-22.809833310205086;0.0
CS;s0001;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;0.22779965006005923
CYTBD;s0001;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;-1.6547366278141024e-14
D_LACt2;s0001;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;s0001;;2pg_c <=> h2o_c + pep_c;14.716139568742859;19.122858387019665
ETOHt2r;s0001;;etoh_e + h_e <=> etoh_c + h_c;0.0;-8.472323479412339
EX_ac_e;s0001;;ac_e --> ;0.0;8.318655312470348
EX_acald_e;s0001;;acald_e --> ;0.0;0.0
EX_akg_e;s0001;;akg_e --> ;0.0;0.0
EX_co2_e;s0001;;co2_e <=> ;22.809833310205086;0.0
EX_etoh_e;s0001;;etoh_e --> ;0.0;8.472323479412339
EX_for_e;s0001;;for_e --> ;0.0;17.4328463757019
EX_fru_e;s0001;;fru_e --> ;0.0;0.0
EX_fum_e;s0001;;fum_e --> ;0.0;0.0
EX_glc__D_e;s0001;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;s0001;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;s0001;;glu__L_e --> ;0.0;0.0
EX_h_e;s0001;;h_e <=> ;17.530865429786523;29.98698317876892
EX_h2o_e;s0001;;h2o_e <=> ;29.175827135565836;-6.934290509816053
EX_lac__D_e;s0001;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;s0001;;mal__L_e --> ;0.0;0.0
EX_nh4_e;s0001;;nh4_e <=> ;-4.765319193197444;-1.1513077503452354
EX_o2_e;s0001;;o2_e <=> ;-21.799492655998886;8.798875280606325e-15
EX_pi_e;s0001;;pi_e <=> ;-3.214895047684769;-0.7767231186170603
EX_pyr_e;s0001;;pyr_e --> ;0.0;0.0
EX_succ_e;s0001;;succ_e --> ;0.0;1.536386688842234e-14
FBA;s0001;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;9.78997839288652
FBP;s0001;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;s0001;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;s0001;;for_c --> for_e;0.0;17.4328463757019
FRD7;s0001;;fum_c + q8h2_c --> q8_c + succ_c;0.0;1.6547366278141024e-14
FRUpts2;s0001;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;s0001;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;-1.621620453890388e-14
FUMt2_2;s0001;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;s0001;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;0.0
GAPD;s0001;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;19.43872480326755
GLCpts;s0001;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;s0001;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.05398866486269013
GLNabc;s0001;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;s0001;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-1.0973190854825454
GLUN;s0001;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;s0001;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;s0001;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;s0001;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;0.0
H2Ot;s0001;;h2o_e <=> h2o_c;-29.175827135565836;6.934290509815987
ICDHyr;s0001;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.22779965006005928
ICL;s0001;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;s0001;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;s0001;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;s0001;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;s0001;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;-1.84285999979242e-14
ME1;s0001;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;s0001;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;s0001;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;0.0
NADTRHD;s0001;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;s0001;;nh4_e <=> nh4_c;4.765319193197444;1.1513077503452356
O2t;s0001;;o2_e --> o2_c;21.799492655998886;0.0
PDH;s0001;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;0.37724500395062394
PFK;s0001;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;9.78997839288652
PFL;s0001;;coa_c + pyr_c --> accoa_c + for_c;0.0;17.4328463757019
PGI;s0001;;g6p_c <=> f6p_c;4.860861146496871;9.956716166222717
PGK;s0001;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-19.438724803267554
PGL;s0001;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;0.0
PGM;s0001;;2pg_c <=> 3pg_c;-14.716139568742859;-19.12285838701966
PIt2r;s0001;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;0.7767231186170603
PPC;s0001;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;0.6050446540106663
PPCK;s0001;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;s0001;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;s0001;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;8.318655312470348
PYK;s0001;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;8.408210620258805
PYRt2;s0001;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;s0001;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;-0.15176790106883897
RPI;s0001;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-0.15176790106883897
SUCCt2_2;s0001;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;s0001;;h_e + succ_c --> h_c + succ_e;0.0;1.536386688842234e-14
SUCDi;s0001;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;0.0
SUCOAS;s0001;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;0.0
TALA;s0001;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;-0.0377730627451524
THD2;s0001;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;3.6202387430667735
TKT1;s0001;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;-0.0377730627451524
TKT2;s0001;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;-0.11399483832368643
TPI;s0001;;dhap_c <=> g3p_c;7.477381962160304;9.78997839288652
ACALD;b3115;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b3115;;acald_e <=> acald_c;0.0;0.0
ACKr;b3115;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;-4.912213865250822e-15
ACONTa;b3115;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350328
ACONTb;b3115;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350328
ACt2r;b3115;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b3115;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b3115;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.06437566148209
AKGt2r;b3115;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b3115;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b3115;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b3115;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517454
Biomass_Ecoli_core;b3115;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b3115;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020496
CS;b3115;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350327
CYTBD;b3115;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199751
D_LACt2;b3115;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b3115;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742829
ETOHt2r;b3115;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b3115;;ac_e --> ;0.0;0.0
EX_acald_e;b3115;;acald_e --> ;0.0;0.0
EX_akg_e;b3115;;akg_e --> ;0.0;0.0
EX_co2_e;b3115;;co2_e <=> ;22.809833310205086;22.80983331020496
EX_etoh_e;b3115;;etoh_e --> ;0.0;0.0
EX_for_e;b3115;;for_e --> ;0.0;0.0
EX_fru_e;b3115;;fru_e --> ;0.0;0.0
EX_fum_e;b3115;;fum_e --> ;0.0;0.0
EX_glc__D_e;b3115;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b3115;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b3115;;glu__L_e --> ;0.0;0.0
EX_h_e;b3115;;h_e <=> ;17.530865429786523;17.530865429786687
EX_h2o_e;b3115;;h2o_e <=> ;29.175827135565836;29.175827135565772
EX_lac__D_e;b3115;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b3115;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b3115;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b3115;;o2_e <=> ;-21.799492655998886;-21.79949265599875
EX_pi_e;b3115;;pi_e <=> ;-3.214895047684769;-3.214895047684754
EX_pyr_e;b3115;;pyr_e --> ;0.0;0.0
EX_succ_e;b3115;;succ_e --> ;0.0;0.0
FBA;b3115;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.4773819621602815
FBP;b3115;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b3115;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b3115;;for_c --> for_e;0.0;0.0
FRD7;b3115;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b3115;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b3115;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.06437566148209
FUMt2_2;b3115;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b3115;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574662
GAPD;b3115;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.0235261431676
GLCpts;b3115;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b3115;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b3115;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b3115;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b3115;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b3115;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b3115;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b3115;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.959984944574661
H2Ot;b3115;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565793
ICDHyr;b3115;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350328
ICL;b3115;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b3115;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b3115;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b3115;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b3115;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.0643756614820905
ME1;b3115;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b3115;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b3115;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515414
NADTRHD;b3115;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b3115;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b3115;;o2_e <=> o2_c;21.799492655998886;21.79949265599875
PDH;b3115;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.282532599166615
PFK;b3115;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160282
PFL;b3115;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b3115;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496811
PGK;b3115;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.023526143167604
PGL;b3115;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.9599849445746615
PGM;b3115;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742829
PIt2r;b3115;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684754
PPC;b3115;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.504309470368732
PPCK;b3115;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b3115;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b3115;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;4.912213865250822e-15
PYK;b3115;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067857
PYRt2;b3115;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b3115;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507534
RPI;b3115;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671286
SUCCt2_2;b3115;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b3115;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b3115;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.06437566148209
SUCOAS;b3115;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.06437566148209
TALA;b3115;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615683
THD2;b3115;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b3115;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615683
TKT2;b3115;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.1814980932459644
TPI;b3115;;dhap_c <=> g3p_c;7.477381962160304;7.4773819621602815
ACALD;b1849;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b1849;;acald_e <=> acald_c;0.0;0.0
ACKr;b1849;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b1849;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b1849;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b1849;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b1849;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b1849;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b1849;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b1849;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b1849;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b1849;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b1849;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b1849;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b1849;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b1849;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b1849;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b1849;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b1849;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b1849;;ac_e --> ;0.0;0.0
EX_acald_e;b1849;;acald_e --> ;0.0;0.0
EX_akg_e;b1849;;akg_e --> ;0.0;0.0
EX_co2_e;b1849;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b1849;;etoh_e --> ;0.0;0.0
EX_for_e;b1849;;for_e --> ;0.0;0.0
EX_fru_e;b1849;;fru_e --> ;0.0;0.0
EX_fum_e;b1849;;fum_e --> ;0.0;0.0
EX_glc__D_e;b1849;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b1849;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b1849;;glu__L_e --> ;0.0;0.0
EX_h_e;b1849;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b1849;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b1849;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b1849;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b1849;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b1849;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b1849;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b1849;;pyr_e --> ;0.0;0.0
EX_succ_e;b1849;;succ_e --> ;0.0;0.0
FBA;b1849;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b1849;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b1849;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b1849;;for_c --> for_e;0.0;0.0
FRD7;b1849;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b1849;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b1849;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b1849;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b1849;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b1849;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b1849;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b1849;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b1849;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b1849;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b1849;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b1849;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b1849;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b1849;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b1849;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b1849;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b1849;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b1849;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b1849;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b1849;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b1849;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b1849;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b1849;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b1849;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b1849;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b1849;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b1849;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b1849;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b1849;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b1849;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b1849;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b1849;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b1849;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b1849;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b1849;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b1849;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b1849;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b1849;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b1849;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b1849;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b1849;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b1849;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b1849;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b1849;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b1849;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b1849;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b1849;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b1849;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b1849;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b1849;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b1849;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b1849;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b2296;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b2296;;acald_e <=> acald_c;0.0;0.0
ACKr;b2296;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b2296;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b2296;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b2296;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b2296;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b2296;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b2296;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b2296;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b2296;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b2296;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b2296;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b2296;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b2296;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b2296;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b2296;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b2296;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b2296;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b2296;;ac_e --> ;0.0;0.0
EX_acald_e;b2296;;acald_e --> ;0.0;0.0
EX_akg_e;b2296;;akg_e --> ;0.0;0.0
EX_co2_e;b2296;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b2296;;etoh_e --> ;0.0;0.0
EX_for_e;b2296;;for_e --> ;0.0;0.0
EX_fru_e;b2296;;fru_e --> ;0.0;0.0
EX_fum_e;b2296;;fum_e --> ;0.0;0.0
EX_glc__D_e;b2296;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b2296;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b2296;;glu__L_e --> ;0.0;0.0
EX_h_e;b2296;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b2296;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b2296;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b2296;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b2296;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b2296;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b2296;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b2296;;pyr_e --> ;0.0;0.0
EX_succ_e;b2296;;succ_e --> ;0.0;0.0
FBA;b2296;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b2296;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b2296;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b2296;;for_c --> for_e;0.0;0.0
FRD7;b2296;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b2296;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b2296;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b2296;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b2296;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b2296;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b2296;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b2296;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b2296;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b2296;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b2296;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b2296;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b2296;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b2296;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b2296;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b2296;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b2296;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b2296;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b2296;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b2296;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b2296;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b2296;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b2296;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b2296;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b2296;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b2296;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b2296;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b2296;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b2296;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b2296;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b2296;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b2296;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b2296;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b2296;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b2296;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b2296;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b2296;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b2296;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b2296;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b2296;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b2296;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b2296;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b2296;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b2296;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b2296;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b2296;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b2296;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b2296;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b2296;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b2296;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b2296;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b2296;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b1276;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b1276;;acald_e <=> acald_c;0.0;0.0
ACKr;b1276;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b1276;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b1276;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b1276;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b1276;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b1276;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b1276;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b1276;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b1276;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b1276;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b1276;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b1276;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b1276;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b1276;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b1276;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b1276;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b1276;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b1276;;ac_e --> ;0.0;0.0
EX_acald_e;b1276;;acald_e --> ;0.0;0.0
EX_akg_e;b1276;;akg_e --> ;0.0;0.0
EX_co2_e;b1276;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b1276;;etoh_e --> ;0.0;0.0
EX_for_e;b1276;;for_e --> ;0.0;0.0
EX_fru_e;b1276;;fru_e --> ;0.0;0.0
EX_fum_e;b1276;;fum_e --> ;0.0;0.0
EX_glc__D_e;b1276;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b1276;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b1276;;glu__L_e --> ;0.0;0.0
EX_h_e;b1276;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b1276;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b1276;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b1276;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b1276;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b1276;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b1276;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b1276;;pyr_e --> ;0.0;0.0
EX_succ_e;b1276;;succ_e --> ;0.0;0.0
FBA;b1276;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b1276;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b1276;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b1276;;for_c --> for_e;0.0;0.0
FRD7;b1276;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b1276;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b1276;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b1276;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b1276;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b1276;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b1276;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b1276;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b1276;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b1276;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b1276;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b1276;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b1276;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b1276;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b1276;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b1276;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b1276;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b1276;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b1276;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b1276;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b1276;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b1276;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b1276;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b1276;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b1276;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b1276;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b1276;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b1276;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b1276;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b1276;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b1276;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b1276;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b1276;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b1276;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b1276;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b1276;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b1276;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b1276;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b1276;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b1276;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b1276;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b1276;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b1276;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b1276;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b1276;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b1276;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b1276;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b1276;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b1276;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b1276;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b1276;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b1276;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b0118;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b0118;;acald_e <=> acald_c;0.0;0.0
ACKr;b0118;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b0118;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b0118;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b0118;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b0118;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b0118;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b0118;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b0118;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b0118;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b0118;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b0118;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b0118;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b0118;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b0118;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b0118;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b0118;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b0118;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b0118;;ac_e --> ;0.0;0.0
EX_acald_e;b0118;;acald_e --> ;0.0;0.0
EX_akg_e;b0118;;akg_e --> ;0.0;0.0
EX_co2_e;b0118;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b0118;;etoh_e --> ;0.0;0.0
EX_for_e;b0118;;for_e --> ;0.0;0.0
EX_fru_e;b0118;;fru_e --> ;0.0;0.0
EX_fum_e;b0118;;fum_e --> ;0.0;0.0
EX_glc__D_e;b0118;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b0118;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b0118;;glu__L_e --> ;0.0;0.0
EX_h_e;b0118;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b0118;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b0118;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b0118;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b0118;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b0118;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b0118;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b0118;;pyr_e --> ;0.0;0.0
EX_succ_e;b0118;;succ_e --> ;0.0;0.0
FBA;b0118;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b0118;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b0118;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b0118;;for_c --> for_e;0.0;0.0
FRD7;b0118;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b0118;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b0118;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b0118;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b0118;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b0118;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b0118;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b0118;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b0118;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b0118;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b0118;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b0118;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b0118;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b0118;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b0118;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b0118;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b0118;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b0118;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b0118;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b0118;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b0118;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b0118;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b0118;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b0118;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b0118;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b0118;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b0118;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b0118;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b0118;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b0118;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b0118;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b0118;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b0118;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b0118;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b0118;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b0118;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b0118;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b0118;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b0118;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b0118;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b0118;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b0118;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b0118;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b0118;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b0118;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b0118;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b0118;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b0118;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b0118;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b0118;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b0118;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b0118;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b0474;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b0474;;acald_e <=> acald_c;0.0;0.0
ACKr;b0474;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b0474;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b0474;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b0474;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b0474;;amp_c + atp_c --> 2.0 adp_c;0.0;0.0
AKGDH;b0474;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b0474;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b0474;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b0474;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b0474;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b0474;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b0474;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b0474;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b0474;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b0474;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b0474;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b0474;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b0474;;ac_e --> ;0.0;0.0
EX_acald_e;b0474;;acald_e --> ;0.0;0.0
EX_akg_e;b0474;;akg_e --> ;0.0;0.0
EX_co2_e;b0474;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b0474;;etoh_e --> ;0.0;0.0
EX_for_e;b0474;;for_e --> ;0.0;0.0
EX_fru_e;b0474;;fru_e --> ;0.0;0.0
EX_fum_e;b0474;;fum_e --> ;0.0;0.0
EX_glc__D_e;b0474;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b0474;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b0474;;glu__L_e --> ;0.0;0.0
EX_h_e;b0474;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b0474;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b0474;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b0474;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b0474;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b0474;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b0474;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b0474;;pyr_e --> ;0.0;0.0
EX_succ_e;b0474;;succ_e --> ;0.0;0.0
FBA;b0474;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b0474;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b0474;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b0474;;for_c --> for_e;0.0;0.0
FRD7;b0474;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b0474;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b0474;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b0474;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b0474;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b0474;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b0474;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b0474;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b0474;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b0474;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b0474;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b0474;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b0474;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b0474;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b0474;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b0474;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b0474;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b0474;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b0474;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b0474;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b0474;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b0474;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b0474;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b0474;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b0474;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b0474;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b0474;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b0474;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b0474;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b0474;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b0474;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b0474;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b0474;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b0474;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b0474;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b0474;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b0474;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b0474;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b0474;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b0474;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b0474;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b0474;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b0474;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b0474;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b0474;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b0474;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b0474;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b0474;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b0474;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b0474;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b0474;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b0474;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b0116;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b0116;;acald_e <=> acald_c;0.0;0.0
ACKr;b0116;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b0116;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;2.8478696059987096
ACONTb;b0116;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;2.8478696059987096
ACt2r;b0116;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b0116;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b0116;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0
AKGt2r;b0116;;akg_e + h_e <=> akg_c + h_c;0.0;-6.294365088138015e-16
ALCD2x;b0116;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b0116;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b0116;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;46.68398285272691
Biomass_Ecoli_core;b0116;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.7823510529477402
CO2t;b0116;;co2_e <=> co2_c;-22.809833310205086;-18.92290382907288
CS;b0116;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;2.847869605998709
CYTBD;b0116;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.82061149072961
D_LACt2;b0116;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b0116;;2pg_c <=> h2o_c + pep_c;14.716139568742859;10.64423255393881
ETOHt2r;b0116;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b0116;;ac_e --> ;0.0;0.0
EX_acald_e;b0116;;acald_e --> ;0.0;0.0
EX_akg_e;b0116;;akg_e --> ;0.0;0.0
EX_co2_e;b0116;;co2_e <=> ;22.809833310205086;18.92290382907288
EX_etoh_e;b0116;;etoh_e --> ;0.0;0.0
EX_for_e;b0116;;for_e --> ;0.0;7.783755937209625
EX_fru_e;b0116;;fru_e --> ;0.0;0.0
EX_fum_e;b0116;;fum_e --> ;0.0;0.0
EX_glc__D_e;b0116;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b0116;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b0116;;glu__L_e --> ;0.0;0.0
EX_h_e;b0116;;h_e <=> ;17.530865429786523;23.477718059341314
EX_h2o_e;b0116;;h2o_e <=> ;29.175827135565836;24.621861839165348
EX_lac__D_e;b0116;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b0116;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b0116;;nh4_e <=> ;-4.765319193197444;-4.2660038215134355
EX_o2_e;b0116;;o2_e <=> ;-21.799492655998886;-21.910305745364802
EX_pi_e;b0116;;pi_e <=> ;-3.214895047684769;-2.8780348184788798
EX_pyr_e;b0116;;pyr_e --> ;0.0;0.0
EX_succ_e;b0116;;succ_e --> ;0.0;0.0
FBA;b0116;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;3.1161489408324865
FBP;b0116;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b0116;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b0116;;for_c --> for_e;0.0;7.783755937209625
FRD7;b0116;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b0116;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b0116;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;2.003791054973398
FUMt2_2;b0116;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b0116;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;18.3169394004012
GAPD;b0116;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;11.81462972914863
GLCpts;b0116;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b0116;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.20004716423873717
GLNabc;b0116;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b0116;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.0659566572746995
GLUN;b0116;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b0116;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b0116;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b0116;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;18.316939400401196
H2Ot;b0116;;h2o_e <=> h2o_c;-29.175827135565836;-24.621861839165348
ICDHyr;b0116;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.8440785510253138
ICL;b0116;;icit_c --> glx_c + succ_c;0.0;2.0037910549733957
LDH_D;b0116;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b0116;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;2.0037910549733957
MALt2_2;b0116;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b0116;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;4.007582109946793
ME1;b0116;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b0116;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b0116;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;41.81682043575621
NADTRHD;b0116;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;23.219609411855135
NH4t;b0116;;nh4_e <=> nh4_c;4.765319193197444;4.2660038215134355
O2t;b0116;;o2_e <=> o2_c;21.799492655998886;21.910305745364802
PDH;b0116;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;0.0
PFK;b0116;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;3.1161489408324865
PFL;b0116;;coa_c + pyr_c --> accoa_c + for_c;0.0;7.783755937209624
PGI;b0116;;g6p_c <=> f6p_c;4.860861146496871;-8.477321366255477
PGK;b0116;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-11.814629729148631
PGL;b0116;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;18.3169394004012
PGM;b0116;;2pg_c <=> 3pg_c;-14.716139568742859;-10.64423255393881
PIt2r;b0116;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;2.8780348184788798
PPC;b0116;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;0.23811412235364124
PPCK;b0116;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b0116;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b0116;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b0116;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;0.0
PYRt2;b0116;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b0116;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;11.64893899674196
RPI;b0116;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-6.668000403659239
SUCCt2_2;b0116;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b0116;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b0116;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;2.003791054973398
SUCOAS;b0116;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-2.275026620207604e-15
TALA;b0116;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;5.965683863428047
THD2;b0116;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b0116;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;5.965683863428046
TKT2;b0116;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;5.683255133313913
TPI;b0116;;dhap_c <=> g3p_c;7.477381962160304;3.1161489408324865
ACALD;b0726;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b0726;;acald_e <=> acald_c;0.0;0.0
ACKr;b0726;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b0726;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;5.83680762209076
ACONTb;b0726;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;5.83680762209076
ACt2r;b0726;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b0726;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b0726;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0
AKGt2r;b0726;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b0726;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b0726;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b0726;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;47.42816442230027
Biomass_Ecoli_core;b0726;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8583074080226888
CO2t;b0726;;co2_e <=> co2_c;-22.809833310205086;-23.474299097890487
CS;b0726;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;5.83680762209076
CYTBD;b0726;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;44.964019806950915
D_LACt2;b0726;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b0726;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.390098435259256
ETOHt2r;b0726;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b0726;;ac_e --> ;0.0;0.0
EX_acald_e;b0726;;acald_e --> ;0.0;0.0
EX_akg_e;b0726;;akg_e --> ;0.0;0.0
EX_co2_e;b0726;;co2_e <=> ;22.809833310205086;23.474299097890487
EX_etoh_e;b0726;;etoh_e --> ;0.0;0.0
EX_for_e;b0726;;for_e --> ;0.0;0.0
EX_fru_e;b0726;;fru_e --> ;0.0;0.0
EX_fum_e;b0726;;fum_e --> ;0.0;0.0
EX_glc__D_e;b0726;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b0726;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b0726;;glu__L_e --> ;0.0;0.0
EX_h_e;b0726;;h_e <=> ;17.530865429786523;17.21764660493515
EX_h2o_e;b0726;;h2o_e <=> ;29.175827135565836;29.72655358089095
EX_lac__D_e;b0726;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b0726;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b0726;;nh4_e <=> ;-4.765319193197444;-4.680178634466116
EX_o2_e;b0726;;o2_e <=> ;-21.799492655998886;-22.482009903475454
EX_pi_e;b0726;;pi_e <=> ;-3.214895047684769;-3.1574554618930675
EX_pyr_e;b0726;;pyr_e --> ;0.0;0.0
EX_succ_e;b0726;;succ_e --> ;0.0;0.0
FBA;b0726;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.102006521647742
FBP;b0726;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b0726;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b0726;;for_c --> for_e;0.0;0.0
FRD7;b0726;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b0726;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b0726;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;4.910779759575083
FUMt2_2;b0726;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b0726;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;6.132705298776269
GAPD;b0726;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;15.674126317661198
GLCpts;b0726;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b0726;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.21946920423140148
GLNabc;b0726;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b0726;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.460709430234715
GLUN;b0726;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b0726;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b0726;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b0726;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;6.132705298776268
H2Ot;b0726;;h2o_e <=> h2o_c;-29.175827135565836;-29.72655358089095
ICDHyr;b0726;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.9260278625156778
ICL;b0726;;icit_c --> glx_c + succ_c;0.0;4.910779759575083
LDH_D;b0726;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b0726;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;4.910779759575083
MALt2_2;b0726;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b0726;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;7.3703454680048965
ME1;b0726;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b0726;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;2.451214051145268
NADH16;b0726;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;40.05324004737582
NADTRHD;b0726;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b0726;;nh4_e <=> nh4_c;4.765319193197444;4.680178634466117
O2t;b0726;;o2_e <=> o2_c;21.799492655998886;22.482009903475454
PDH;b0726;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;13.964351885453276
PFK;b0726;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.102006521647743
PFL;b0726;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b0726;;g6p_c <=> f6p_c;4.860861146496871;3.6913416825790755
PGK;b0726;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-15.674126317661202
PGL;b0726;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;6.132705298776269
PGM;b0726;;2pg_c <=> 3pg_c;-14.716139568742859;-14.390098435259256
PIt2r;b0726;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.1574554618930675
PPC;b0726;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;0.0
PPCK;b0726;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b0726;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b0726;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b0726;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;3.9445510597546773
PYRt2;b0726;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b0726;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;3.4715188342974694
RPI;b0726;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.6611864644787984
SUCCt2_2;b0726;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b0726;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b0726;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;4.910779759575083
SUCOAS;b0726;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;0.0
TALA;b0726;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.8906839042968304
THD2;b0726;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b0726;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.89068390429683
TKT2;b0726;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.5808349300006397
TPI;b0726;;dhap_c <=> g3p_c;7.477381962160304;7.102006521647742
ACALD;b0727;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b0727;;acald_e <=> acald_c;0.0;0.0
ACKr;b0727;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b0727;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;5.836807622090764
ACONTb;b0727;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;5.836807622090764
ACt2r;b0727;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b0727;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b0727;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0
AKGt2r;b0727;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b0727;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b0727;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b0727;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;47.42816442230032
Biomass_Ecoli_core;b0727;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.858307408022689
CO2t;b0727;;co2_e <=> co2_c;-22.809833310205086;-23.4742990978905
CS;b0727;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;5.836807622090764
CYTBD;b0727;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;44.964019806950944
D_LACt2;b0727;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b0727;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.390098435259251
ETOHt2r;b0727;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b0727;;ac_e --> ;0.0;0.0
EX_acald_e;b0727;;acald_e --> ;0.0;0.0
EX_akg_e;b0727;;akg_e --> ;0.0;0.0
EX_co2_e;b0727;;co2_e <=> ;22.809833310205086;23.4742990978905
EX_etoh_e;b0727;;etoh_e --> ;0.0;0.0
EX_for_e;b0727;;for_e --> ;0.0;0.0
EX_fru_e;b0727;;fru_e --> ;0.0;0.0
EX_fum_e;b0727;;fum_e --> ;0.0;0.0
EX_glc__D_e;b0727;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b0727;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b0727;;glu__L_e --> ;0.0;0.0
EX_h_e;b0727;;h_e <=> ;17.530865429786523;17.217646604935073
EX_h2o_e;b0727;;h2o_e <=> ;29.175827135565836;29.726553580890982
EX_lac__D_e;b0727;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b0727;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b0727;;nh4_e <=> ;-4.765319193197444;-4.680178634466118
EX_o2_e;b0727;;o2_e <=> ;-21.799492655998886;-22.48200990347547
EX_pi_e;b0727;;pi_e <=> ;-3.214895047684769;-3.1574554618930946
EX_pyr_e;b0727;;pyr_e --> ;0.0;0.0
EX_succ_e;b0727;;succ_e --> ;0.0;0.0
FBA;b0727;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.1020065216477395
FBP;b0727;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b0727;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b0727;;for_c --> for_e;0.0;0.0
FRD7;b0727;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b0727;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b0727;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;4.910779759575085
FUMt2_2;b0727;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b0727;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;6.132705298776282
GAPD;b0727;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;15.674126317661196
GLCpts;b0727;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b0727;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.21946920423140157
GLNabc;b0727;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b0727;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.460709430234716
GLUN;b0727;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b0727;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b0727;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b0727;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;6.132705298776281
H2Ot;b0727;;h2o_e <=> h2o_c;-29.175827135565836;-29.726553580890982
ICDHyr;b0727;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.9260278625156771
ICL;b0727;;icit_c --> glx_c + succ_c;0.0;4.910779759575085
LDH_D;b0727;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b0727;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;4.910779759575085
MALt2_2;b0727;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b0727;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;7.370345468004903
ME1;b0727;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b0727;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;2.4512140511452674
NADH16;b0727;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;40.05324004737586
NADTRHD;b0727;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b0727;;nh4_e <=> nh4_c;4.765319193197444;4.680178634466118
O2t;b0727;;o2_e <=> o2_c;21.799492655998886;22.48200990347547
PDH;b0727;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;13.964351885453283
PFK;b0727;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.1020065216477395
PFL;b0727;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b0727;;g6p_c <=> f6p_c;4.860861146496871;3.6913416825790697
PGK;b0727;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-15.674126317661198
PGL;b0727;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;6.1327052987762825
PGM;b0727;;2pg_c <=> 3pg_c;-14.716139568742859;-14.390098435259251
PIt2r;b0727;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.1574554618930946
PPC;b0727;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;0.0
PPCK;b0727;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b0727;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b0727;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b0727;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;3.9445510597546733
PYRt2;b0727;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b0727;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;3.4715188342974783
RPI;b0727;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.6611864644788032
SUCCt2_2;b0727;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b0727;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b0727;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;4.910779759575085
SUCOAS;b0727;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;0.0
TALA;b0727;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.8906839042968346
THD2;b0727;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b0727;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.8906839042968344
TKT2;b0727;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.580834930000644
TPI;b0727;;dhap_c <=> g3p_c;7.477381962160304;7.1020065216477395
ACALD;b2587;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b2587;;acald_e <=> acald_c;0.0;0.0
ACKr;b2587;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b2587;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350335
ACONTb;b2587;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350335
ACt2r;b2587;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b2587;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b2587;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.0643756614820985
AKGt2r;b2587;;akg_e + h_e --> akg_c + h_c;0.0;0.0
ALCD2x;b2587;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b2587;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b2587;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.51400977451749
Biomass_Ecoli_core;b2587;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b2587;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020498
CS;b2587;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350334
CYTBD;b2587;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199754
D_LACt2;b2587;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b2587;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742832
ETOHt2r;b2587;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b2587;;ac_e --> ;0.0;0.0
EX_acald_e;b2587;;acald_e --> ;0.0;0.0
EX_akg_e;b2587;;akg_e --> ;0.0;0.0
EX_co2_e;b2587;;co2_e <=> ;22.809833310205086;22.80983331020498
EX_etoh_e;b2587;;etoh_e --> ;0.0;0.0
EX_for_e;b2587;;for_e --> ;0.0;0.0
EX_fru_e;b2587;;fru_e --> ;0.0;0.0
EX_fum_e;b2587;;fum_e --> ;0.0;0.0
EX_glc__D_e;b2587;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b2587;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b2587;;glu__L_e --> ;0.0;0.0
EX_h_e;b2587;;h_e <=> ;17.530865429786523;17.53086542978658
EX_h2o_e;b2587;;h2o_e <=> ;29.175827135565836;29.17582713556585
EX_lac__D_e;b2587;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b2587;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b2587;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b2587;;o2_e <=> ;-21.799492655998886;-21.799492655998765
EX_pi_e;b2587;;pi_e <=> ;-3.214895047684769;-3.2148950476847955
EX_pyr_e;b2587;;pyr_e --> ;0.0;0.0
EX_succ_e;b2587;;succ_e --> ;0.0;0.0
FBA;b2587;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160283
FBP;b2587;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b2587;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b2587;;for_c --> for_e;0.0;0.0
FRD7;b2587;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b2587;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b2587;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.0643756614820985
FUMt2_2;b2587;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b2587;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.95998494457466
GAPD;b2587;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167604
GLCpts;b2587;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b2587;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b2587;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b2587;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b2587;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b2587;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b2587;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b2587;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.959984944574659
H2Ot;b2587;;h2o_e <=> h2o_c;-29.175827135565836;-29.17582713556585
ICDHyr;b2587;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b2587;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b2587;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b2587;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b2587;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b2587;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482099
ME1;b2587;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b2587;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b2587;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b2587;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b2587;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b2587;;o2_e <=> o2_c;21.799492655998886;21.799492655998765
PDH;b2587;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.282532599166618
PFK;b2587;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160284
PFL;b2587;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b2587;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496814
PGK;b2587;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.023526143167608
PGL;b2587;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574659
PGM;b2587;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742832
PIt2r;b2587;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.2148950476847955
PPC;b2587;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687308
PPCK;b2587;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b2587;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b2587;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b2587;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.758177444106788
PYRt2;b2587;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b2587;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507531
RPI;b2587;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671277
SUCCt2_2;b2587;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b2587;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b2587;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.0643756614820985
SUCOAS;b2587;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.0643756614820985
TALA;b2587;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615674
THD2;b2587;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b2587;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615672
TKT2;b2587;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245964
TPI;b2587;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160283
ACALD;b0356;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b0356;;acald_e <=> acald_c;0.0;0.0
ACKr;b0356;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b0356;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b0356;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b0356;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b0356;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b0356;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b0356;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b0356;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b0356;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b0356;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b0356;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b0356;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b0356;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b0356;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b0356;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b0356;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b0356;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b0356;;ac_e --> ;0.0;0.0
EX_acald_e;b0356;;acald_e --> ;0.0;0.0
EX_akg_e;b0356;;akg_e --> ;0.0;0.0
EX_co2_e;b0356;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b0356;;etoh_e --> ;0.0;0.0
EX_for_e;b0356;;for_e --> ;0.0;0.0
EX_fru_e;b0356;;fru_e --> ;0.0;0.0
EX_fum_e;b0356;;fum_e --> ;0.0;0.0
EX_glc__D_e;b0356;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b0356;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b0356;;glu__L_e --> ;0.0;0.0
EX_h_e;b0356;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b0356;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b0356;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b0356;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b0356;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b0356;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b0356;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b0356;;pyr_e --> ;0.0;0.0
EX_succ_e;b0356;;succ_e --> ;0.0;0.0
FBA;b0356;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b0356;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b0356;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b0356;;for_c --> for_e;0.0;0.0
FRD7;b0356;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b0356;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b0356;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b0356;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b0356;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b0356;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b0356;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b0356;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b0356;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b0356;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b0356;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b0356;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b0356;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b0356;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b0356;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b0356;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b0356;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b0356;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b0356;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b0356;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b0356;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b0356;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b0356;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b0356;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b0356;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b0356;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b0356;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b0356;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b0356;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b0356;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b0356;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b0356;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b0356;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b0356;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b0356;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b0356;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b0356;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b0356;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b0356;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b0356;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b0356;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b0356;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b0356;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b0356;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b0356;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b0356;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b0356;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b0356;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b0356;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b0356;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b0356;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b0356;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b1478;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b1478;;acald_e <=> acald_c;0.0;0.0
ACKr;b1478;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b1478;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b1478;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b1478;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b1478;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b1478;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b1478;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b1478;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b1478;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b1478;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b1478;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b1478;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b1478;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b1478;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b1478;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b1478;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b1478;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b1478;;ac_e --> ;0.0;0.0
EX_acald_e;b1478;;acald_e --> ;0.0;0.0
EX_akg_e;b1478;;akg_e --> ;0.0;0.0
EX_co2_e;b1478;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b1478;;etoh_e --> ;0.0;0.0
EX_for_e;b1478;;for_e --> ;0.0;0.0
EX_fru_e;b1478;;fru_e --> ;0.0;0.0
EX_fum_e;b1478;;fum_e --> ;0.0;0.0
EX_glc__D_e;b1478;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b1478;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b1478;;glu__L_e --> ;0.0;0.0
EX_h_e;b1478;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b1478;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b1478;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b1478;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b1478;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b1478;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b1478;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b1478;;pyr_e --> ;0.0;0.0
EX_succ_e;b1478;;succ_e --> ;0.0;0.0
FBA;b1478;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b1478;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b1478;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b1478;;for_c --> for_e;0.0;0.0
FRD7;b1478;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b1478;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b1478;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b1478;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b1478;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b1478;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b1478;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b1478;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b1478;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b1478;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b1478;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b1478;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b1478;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b1478;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b1478;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b1478;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b1478;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b1478;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b1478;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b1478;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b1478;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b1478;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b1478;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b1478;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b1478;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b1478;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b1478;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b1478;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b1478;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b1478;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b1478;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b1478;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b1478;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b1478;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b1478;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b1478;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b1478;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b1478;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b1478;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b1478;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b1478;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b1478;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b1478;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b1478;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b1478;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b1478;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b1478;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b1478;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b1478;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b1478;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b1478;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b1478;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b3735;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;-7.867597117252571e-16
ACALDt;b3735;;acald_e <=> acald_c;0.0;0.0
ACKr;b3735;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;-14.312267245829135
ACONTa;b3735;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;0.4037566120653205
ACONTb;b3735;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;0.40375661206532054
ACt2r;b3735;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;-14.312267245829135
ADK1;b3735;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b3735;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0
AKGt2r;b3735;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b3735;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;-7.867597117252571e-16
ATPM;b3735;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b3735;;adp_c + 4.0 h_e + pi_c --> atp_c + h2o_c + 3.0 h_c;45.51400977451776;0.0
Biomass_Ecoli_core;b3735;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.374229874933111
CO2t;b3735;;co2_e <=> co2_c;-22.809833310205086;0.0
CS;b3735;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;0.40375661206532043
CYTBD;b3735;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;14.58463174880539
D_LACt2;b3735;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;-8.825244427412039e-15
ENO;b3735;;2pg_c <=> h2o_c + pep_c;14.716139568742859;18.445336830565378
ETOHt2r;b3735;;etoh_e + h_e <=> etoh_c + h_c;0.0;-7.867597117252571e-16
EX_ac_e;b3735;;ac_e --> ;0.0;14.312267245829135
EX_acald_e;b3735;;acald_e --> ;0.0;0.0
EX_akg_e;b3735;;akg_e --> ;0.0;0.0
EX_co2_e;b3735;;co2_e <=> ;22.809833310205086;0.0
EX_etoh_e;b3735;;etoh_e --> ;0.0;0.0
EX_for_e;b3735;;for_e --> ;0.0;15.44992606562574
EX_fru_e;b3735;;fru_e --> ;0.0;0.0
EX_fum_e;b3735;;fum_e --> ;0.0;0.0
EX_glc__D_e;b3735;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b3735;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b3735;;glu__L_e --> ;0.0;0.0
EX_h_e;b3735;;h_e <=> ;17.530865429786523;37.269244602613135
EX_h2o_e;b3735;;h2o_e <=> ;29.175827135565836;2.72604010096266
EX_lac__D_e;b3735;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b3735;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b3735;;nh4_e <=> ;-4.765319193197444;-2.040600662035267
EX_o2_e;b3735;;o2_e <=> ;-21.799492655998886;-7.292315874402702
EX_pi_e;b3735;;pi_e <=> ;-3.214895047684769;-1.37667944091645
EX_pyr_e;b3735;;pyr_e --> ;0.0;0.0
EX_succ_e;b3735;;succ_e --> ;0.0;0.0
FBA;b3735;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;9.627753543404037
FBP;b3735;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b3735;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b3735;;for_c --> for_e;0.0;15.44992606562574
FRD7;b3735;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b3735;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b3735;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;-2.586245375694104e-14
FUMt2_2;b3735;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b3735;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;0.0
GAPD;b3735;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;19.005184723465316
GLCpts;b3735;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b3735;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.09569057902039647
GLNabc;b3735;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b3735;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-1.9449100830148707
GLUN;b3735;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b3735;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b3735;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b3735;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;0.0
H2Ot;b3735;;h2o_e <=> h2o_c;-29.175827135565836;-2.72604010096266
ICDHyr;b3735;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.40375661206532054
ICL;b3735;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b3735;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b3735;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b3735;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b3735;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;-2.4714245655065478e-14
ME1;b3735;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b3735;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b3735;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;14.584631748805416
NADTRHD;b3735;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b3735;;nh4_e <=> nh4_c;4.765319193197444;2.040600662035267
O2t;b3735;;o2_e <=> o2_c;21.799492655998886;7.292315874402694
PDH;b3735;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;0.6686365175430308
PFK;b3735;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;9.627753543404037
PFL;b3735;;coa_c + pyr_c --> accoa_c + for_c;0.0;15.449926065625737
PGI;b3735;;g6p_c <=> f6p_c;4.860861146496871;9.923282875638714
PGK;b3735;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-19.005184723465316
PGL;b3735;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;0.0
PGM;b3735;;2pg_c <=> 3pg_c;-14.716139568742859;-18.445336830565378
PIt2r;b3735;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;1.37667944091645
PPC;b3735;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;1.0723931296083171
PPCK;b3735;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b3735;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b3735;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;14.312267245829137
PYK;b3735;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;7.178680972879282
PYRt2;b3735;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b3735;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;-0.268996434101926
RPI;b3735;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-0.268996434101926
SUCCt2_2;b3735;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;11.918778743048437
SUCCt3;b3735;;h_e + succ_c --> h_c + succ_e;0.0;11.918778743048437
SUCDi;b3735;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;-2.8522595376073667e-14
SUCOAS;b3735;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;1.8200212961660833e-14
TALA;b3735;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;-0.06694972462553657
THD2;b3735;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;6.416582858590636
TKT1;b3735;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;-0.06694972462553656
TKT2;b3735;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;-0.20204670947638942
TPI;b3735;;dhap_c <=> g3p_c;7.477381962160304;9.627753543404037
ACALD;b3733;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b3733;;acald_e <=> acald_c;0.0;0.0
ACKr;b3733;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;-14.312267245829123
ACONTa;b3733;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;0.4037566120653314
ACONTb;b3733;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;0.4037566120653315
ACt2r;b3733;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;-14.312267245829124
ADK1;b3733;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b3733;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0
AKGt2r;b3733;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b3733;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b3733;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b3733;;adp_c + 4.0 h_e + pi_c --> atp_c + h2o_c + 3.0 h_c;45.51400977451776;0.0
Biomass_Ecoli_core;b3733;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.3742298749331097
CO2t;b3733;;co2_e <=> co2_c;-22.809833310205086;0.0
CS;b3733;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;0.4037566120653314
CYTBD;b3733;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;14.584631748805457
D_LACt2;b3733;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b3733;;2pg_c <=> h2o_c + pep_c;14.716139568742859;18.445336830565385
ETOHt2r;b3733;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b3733;;ac_e --> ;0.0;14.312267245829124
EX_acald_e;b3733;;acald_e --> ;0.0;0.0
EX_akg_e;b3733;;akg_e --> ;0.0;0.0
EX_co2_e;b3733;;co2_e <=> ;22.809833310205086;0.0
EX_etoh_e;b3733;;etoh_e --> ;0.0;0.0
EX_for_e;b3733;;for_e --> ;0.0;15.44992606562578
EX_fru_e;b3733;;fru_e --> ;0.0;0.0
EX_fum_e;b3733;;fum_e --> ;0.0;0.0
EX_glc__D_e;b3733;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b3733;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b3733;;glu__L_e --> ;0.0;0.0
EX_h_e;b3733;;h_e <=> ;17.530865429786523;37.26924460261309
EX_h2o_e;b3733;;h2o_e <=> ;29.175827135565836;2.726040100962767
EX_lac__D_e;b3733;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b3733;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b3733;;nh4_e <=> ;-4.765319193197444;-2.04060066203526
EX_o2_e;b3733;;o2_e <=> ;-21.799492655998886;-7.292315874402727
EX_pi_e;b3733;;pi_e <=> ;-3.214895047684769;-1.3766794409164365
EX_pyr_e;b3733;;pyr_e --> ;0.0;0.0
EX_succ_e;b3733;;succ_e --> ;0.0;0.0
FBA;b3733;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;9.627753543404037
FBP;b3733;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b3733;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b3733;;for_c --> for_e;0.0;15.44992606562578
FRD7;b3733;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b3733;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b3733;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;0.0
FUMt2_2;b3733;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b3733;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;0.0
GAPD;b3733;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;19.005184723465316
GLCpts;b3733;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b3733;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.09569057902039614
GLNabc;b3733;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b3733;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-1.944910083014864
GLUN;b3733;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b3733;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b3733;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b3733;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;0.0
H2Ot;b3733;;h2o_e <=> h2o_c;-29.175827135565836;-2.726040100962767
ICDHyr;b3733;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.4037566120653315
ICL;b3733;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b3733;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b3733;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b3733;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b3733;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;0.0
ME1;b3733;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b3733;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b3733;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;14.584631748805455
NADTRHD;b3733;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b3733;;nh4_e <=> nh4_c;4.765319193197444;2.04060066203526
O2t;b3733;;o2_e <=> o2_c;21.799492655998886;7.292315874402727
PDH;b3733;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;0.6686365175429876
PFK;b3733;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;9.627753543404037
PFL;b3733;;coa_c + pyr_c --> accoa_c + for_c;0.0;15.44992606562578
PGI;b3733;;g6p_c <=> f6p_c;4.860861146496871;9.923282875638714
PGK;b3733;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-19.00518472346532
PGL;b3733;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;0.0
PGM;b3733;;2pg_c <=> 3pg_c;-14.716139568742859;-18.445336830565385
PIt2r;b3733;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;1.3766794409164365
PPC;b3733;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;1.072393129608319
PPCK;b3733;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b3733;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b3733;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;14.312267245829123
PYK;b3733;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;7.1786809728792855
PYRt2;b3733;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b3733;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;-0.2689964341019193
RPI;b3733;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-0.26899643410191926
SUCCt2_2;b3733;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;11.91877874304856
SUCCt3;b3733;;h_e + succ_c --> h_c + succ_e;0.0;11.91877874304856
SUCDi;b3733;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;0.0
SUCOAS;b3733;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;0.0
TALA;b3733;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;-0.06694972462553335
THD2;b3733;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;6.416582858590592
TKT1;b3733;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;-0.06694972462553334
TKT2;b3733;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;-0.20204670947638592
TPI;b3733;;dhap_c <=> g3p_c;7.477381962160304;9.627753543404037
ACALD;b3734;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b3734;;acald_e <=> acald_c;0.0;0.0
ACKr;b3734;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;-14.312267245829123
ACONTa;b3734;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;0.4037566120653314
ACONTb;b3734;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;0.4037566120653315
ACt2r;b3734;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;-14.312267245829124
ADK1;b3734;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b3734;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0
AKGt2r;b3734;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b3734;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b3734;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b3734;;adp_c + 4.0 h_e + pi_c --> atp_c + h2o_c + 3.0 h_c;45.51400977451776;0.0
Biomass_Ecoli_core;b3734;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.3742298749331097
CO2t;b3734;;co2_e <=> co2_c;-22.809833310205086;0.0
CS;b3734;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;0.4037566120653314
CYTBD;b3734;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;14.584631748805457
D_LACt2;b3734;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b3734;;2pg_c <=> h2o_c + pep_c;14.716139568742859;18.445336830565385
ETOHt2r;b3734;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b3734;;ac_e --> ;0.0;14.312267245829124
EX_acald_e;b3734;;acald_e --> ;0.0;0.0
EX_akg_e;b3734;;akg_e --> ;0.0;0.0
EX_co2_e;b3734;;co2_e <=> ;22.809833310205086;0.0
EX_etoh_e;b3734;;etoh_e --> ;0.0;0.0
EX_for_e;b3734;;for_e --> ;0.0;15.44992606562578
EX_fru_e;b3734;;fru_e --> ;0.0;0.0
EX_fum_e;b3734;;fum_e --> ;0.0;0.0
EX_glc__D_e;b3734;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b3734;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b3734;;glu__L_e --> ;0.0;0.0
EX_h_e;b3734;;h_e <=> ;17.530865429786523;37.26924460261309
EX_h2o_e;b3734;;h2o_e <=> ;29.175827135565836;2.726040100962767
EX_lac__D_e;b3734;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b3734;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b3734;;nh4_e <=> ;-4.765319193197444;-2.04060066203526
EX_o2_e;b3734;;o2_e <=> ;-21.799492655998886;-7.292315874402727
EX_pi_e;b3734;;pi_e <=> ;-3.214895047684769;-1.3766794409164365
EX_pyr_e;b3734;;pyr_e --> ;0.0;0.0
EX_succ_e;b3734;;succ_e --> ;0.0;0.0
FBA;b3734;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;9.627753543404037
FBP;b3734;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b3734;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b3734;;for_c --> for_e;0.0;15.44992606562578
FRD7;b3734;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b3734;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b3734;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;0.0
FUMt2_2;b3734;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b3734;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;0.0
GAPD;b3734;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;19.005184723465316
GLCpts;b3734;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b3734;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.09569057902039614
GLNabc;b3734;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b3734;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-1.944910083014864
GLUN;b3734;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b3734;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b3734;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b3734;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;0.0
H2Ot;b3734;;h2o_e <=> h2o_c;-29.175827135565836;-2.726040100962767
ICDHyr;b3734;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.4037566120653315
ICL;b3734;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b3734;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b3734;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b3734;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b3734;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;0.0
ME1;b3734;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b3734;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b3734;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;14.584631748805455
NADTRHD;b3734;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b3734;;nh4_e <=> nh4_c;4.765319193197444;2.04060066203526
O2t;b3734;;o2_e <=> o2_c;21.799492655998886;7.292315874402727
PDH;b3734;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;0.6686365175429876
PFK;b3734;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;9.627753543404037
PFL;b3734;;coa_c + pyr_c --> accoa_c + for_c;0.0;15.44992606562578
PGI;b3734;;g6p_c <=> f6p_c;4.860861146496871;9.923282875638714
PGK;b3734;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-19.00518472346532
PGL;b3734;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;0.0
PGM;b3734;;2pg_c <=> 3pg_c;-14.716139568742859;-18.445336830565385
PIt2r;b3734;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;1.3766794409164365
PPC;b3734;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;1.072393129608319
PPCK;b3734;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b3734;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b3734;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;14.312267245829123
PYK;b3734;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;7.1786809728792855
PYRt2;b3734;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b3734;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;-0.2689964341019193
RPI;b3734;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-0.26899643410191926
SUCCt2_2;b3734;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;11.91877874304856
SUCCt3;b3734;;h_e + succ_c --> h_c + succ_e;0.0;11.91877874304856
SUCDi;b3734;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;0.0
SUCOAS;b3734;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;0.0
TALA;b3734;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;-0.06694972462553335
THD2;b3734;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;6.416582858590592
TKT1;b3734;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;-0.06694972462553334
TKT2;b3734;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;-0.20204670947638592
TPI;b3734;;dhap_c <=> g3p_c;7.477381962160304;9.627753543404037
ACALD;b3732;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b3732;;acald_e <=> acald_c;0.0;0.0
ACKr;b3732;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;-14.312267245829123
ACONTa;b3732;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;0.4037566120653314
ACONTb;b3732;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;0.4037566120653315
ACt2r;b3732;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;-14.312267245829124
ADK1;b3732;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b3732;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0
AKGt2r;b3732;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b3732;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b3732;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b3732;;adp_c + 4.0 h_e + pi_c --> atp_c + h2o_c + 3.0 h_c;45.51400977451776;0.0
Biomass_Ecoli_core;b3732;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.3742298749331097
CO2t;b3732;;co2_e <=> co2_c;-22.809833310205086;0.0
CS;b3732;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;0.4037566120653314
CYTBD;b3732;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;14.584631748805457
D_LACt2;b3732;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b3732;;2pg_c <=> h2o_c + pep_c;14.716139568742859;18.445336830565385
ETOHt2r;b3732;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b3732;;ac_e --> ;0.0;14.312267245829124
EX_acald_e;b3732;;acald_e --> ;0.0;0.0
EX_akg_e;b3732;;akg_e --> ;0.0;0.0
EX_co2_e;b3732;;co2_e <=> ;22.809833310205086;0.0
EX_etoh_e;b3732;;etoh_e --> ;0.0;0.0
EX_for_e;b3732;;for_e --> ;0.0;15.44992606562578
EX_fru_e;b3732;;fru_e --> ;0.0;0.0
EX_fum_e;b3732;;fum_e --> ;0.0;0.0
EX_glc__D_e;b3732;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b3732;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b3732;;glu__L_e --> ;0.0;0.0
EX_h_e;b3732;;h_e <=> ;17.530865429786523;37.26924460261309
EX_h2o_e;b3732;;h2o_e <=> ;29.175827135565836;2.726040100962767
EX_lac__D_e;b3732;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b3732;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b3732;;nh4_e <=> ;-4.765319193197444;-2.04060066203526
EX_o2_e;b3732;;o2_e <=> ;-21.799492655998886;-7.292315874402727
EX_pi_e;b3732;;pi_e <=> ;-3.214895047684769;-1.3766794409164365
EX_pyr_e;b3732;;pyr_e --> ;0.0;0.0
EX_succ_e;b3732;;succ_e --> ;0.0;0.0
FBA;b3732;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;9.627753543404037
FBP;b3732;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b3732;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b3732;;for_c --> for_e;0.0;15.44992606562578
FRD7;b3732;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b3732;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b3732;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;0.0
FUMt2_2;b3732;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b3732;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;0.0
GAPD;b3732;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;19.005184723465316
GLCpts;b3732;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b3732;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.09569057902039614
GLNabc;b3732;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b3732;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-1.944910083014864
GLUN;b3732;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b3732;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b3732;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b3732;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;0.0
H2Ot;b3732;;h2o_e <=> h2o_c;-29.175827135565836;-2.726040100962767
ICDHyr;b3732;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.4037566120653315
ICL;b3732;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b3732;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b3732;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b3732;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b3732;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;0.0
ME1;b3732;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b3732;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b3732;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;14.584631748805455
NADTRHD;b3732;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b3732;;nh4_e <=> nh4_c;4.765319193197444;2.04060066203526
O2t;b3732;;o2_e <=> o2_c;21.799492655998886;7.292315874402727
PDH;b3732;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;0.6686365175429876
PFK;b3732;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;9.627753543404037
PFL;b3732;;coa_c + pyr_c --> accoa_c + for_c;0.0;15.44992606562578
PGI;b3732;;g6p_c <=> f6p_c;4.860861146496871;9.923282875638714
PGK;b3732;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-19.00518472346532
PGL;b3732;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;0.0
PGM;b3732;;2pg_c <=> 3pg_c;-14.716139568742859;-18.445336830565385
PIt2r;b3732;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;1.3766794409164365
PPC;b3732;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;1.072393129608319
PPCK;b3732;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b3732;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b3732;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;14.312267245829123
PYK;b3732;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;7.1786809728792855
PYRt2;b3732;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b3732;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;-0.2689964341019193
RPI;b3732;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-0.26899643410191926
SUCCt2_2;b3732;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;11.91877874304856
SUCCt3;b3732;;h_e + succ_c --> h_c + succ_e;0.0;11.91877874304856
SUCDi;b3732;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;0.0
SUCOAS;b3732;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;0.0
TALA;b3732;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;-0.06694972462553335
THD2;b3732;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;6.416582858590592
TKT1;b3732;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;-0.06694972462553334
TKT2;b3732;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;-0.20204670947638592
TPI;b3732;;dhap_c <=> g3p_c;7.477381962160304;9.627753543404037
ACALD;b3736;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b3736;;acald_e <=> acald_c;0.0;0.0
ACKr;b3736;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;-14.312267245829123
ACONTa;b3736;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;0.4037566120653314
ACONTb;b3736;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;0.4037566120653315
ACt2r;b3736;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;-14.312267245829124
ADK1;b3736;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b3736;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0
AKGt2r;b3736;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b3736;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b3736;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b3736;;adp_c + 4.0 h_e + pi_c --> atp_c + h2o_c + 3.0 h_c;45.51400977451776;0.0
Biomass_Ecoli_core;b3736;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.3742298749331097
CO2t;b3736;;co2_e <=> co2_c;-22.809833310205086;0.0
CS;b3736;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;0.4037566120653314
CYTBD;b3736;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;14.584631748805457
D_LACt2;b3736;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b3736;;2pg_c <=> h2o_c + pep_c;14.716139568742859;18.445336830565385
ETOHt2r;b3736;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b3736;;ac_e --> ;0.0;14.312267245829124
EX_acald_e;b3736;;acald_e --> ;0.0;0.0
EX_akg_e;b3736;;akg_e --> ;0.0;0.0
EX_co2_e;b3736;;co2_e <=> ;22.809833310205086;0.0
EX_etoh_e;b3736;;etoh_e --> ;0.0;0.0
EX_for_e;b3736;;for_e --> ;0.0;15.44992606562578
EX_fru_e;b3736;;fru_e --> ;0.0;0.0
EX_fum_e;b3736;;fum_e --> ;0.0;0.0
EX_glc__D_e;b3736;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b3736;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b3736;;glu__L_e --> ;0.0;0.0
EX_h_e;b3736;;h_e <=> ;17.530865429786523;37.26924460261309
EX_h2o_e;b3736;;h2o_e <=> ;29.175827135565836;2.726040100962767
EX_lac__D_e;b3736;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b3736;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b3736;;nh4_e <=> ;-4.765319193197444;-2.04060066203526
EX_o2_e;b3736;;o2_e <=> ;-21.799492655998886;-7.292315874402727
EX_pi_e;b3736;;pi_e <=> ;-3.214895047684769;-1.3766794409164365
EX_pyr_e;b3736;;pyr_e --> ;0.0;0.0
EX_succ_e;b3736;;succ_e --> ;0.0;0.0
FBA;b3736;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;9.627753543404037
FBP;b3736;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b3736;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b3736;;for_c --> for_e;0.0;15.44992606562578
FRD7;b3736;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b3736;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b3736;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;0.0
FUMt2_2;b3736;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b3736;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;0.0
GAPD;b3736;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;19.005184723465316
GLCpts;b3736;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b3736;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.09569057902039614
GLNabc;b3736;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b3736;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-1.944910083014864
GLUN;b3736;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b3736;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b3736;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b3736;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;0.0
H2Ot;b3736;;h2o_e <=> h2o_c;-29.175827135565836;-2.726040100962767
ICDHyr;b3736;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.4037566120653315
ICL;b3736;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b3736;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b3736;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b3736;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b3736;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;0.0
ME1;b3736;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b3736;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b3736;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;14.584631748805455
NADTRHD;b3736;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b3736;;nh4_e <=> nh4_c;4.765319193197444;2.04060066203526
O2t;b3736;;o2_e <=> o2_c;21.799492655998886;7.292315874402727
PDH;b3736;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;0.6686365175429876
PFK;b3736;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;9.627753543404037
PFL;b3736;;coa_c + pyr_c --> accoa_c + for_c;0.0;15.44992606562578
PGI;b3736;;g6p_c <=> f6p_c;4.860861146496871;9.923282875638714
PGK;b3736;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-19.00518472346532
PGL;b3736;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;0.0
PGM;b3736;;2pg_c <=> 3pg_c;-14.716139568742859;-18.445336830565385
PIt2r;b3736;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;1.3766794409164365
PPC;b3736;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;1.072393129608319
PPCK;b3736;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b3736;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b3736;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;14.312267245829123
PYK;b3736;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;7.1786809728792855
PYRt2;b3736;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b3736;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;-0.2689964341019193
RPI;b3736;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-0.26899643410191926
SUCCt2_2;b3736;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;11.91877874304856
SUCCt3;b3736;;h_e + succ_c --> h_c + succ_e;0.0;11.91877874304856
SUCDi;b3736;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;0.0
SUCOAS;b3736;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;0.0
TALA;b3736;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;-0.06694972462553335
THD2;b3736;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;6.416582858590592
TKT1;b3736;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;-0.06694972462553334
TKT2;b3736;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;-0.20204670947638592
TPI;b3736;;dhap_c <=> g3p_c;7.477381962160304;9.627753543404037
ACALD;b3738;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b3738;;acald_e <=> acald_c;0.0;0.0
ACKr;b3738;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;-14.312267245829123
ACONTa;b3738;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;0.4037566120653314
ACONTb;b3738;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;0.4037566120653315
ACt2r;b3738;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;-14.312267245829124
ADK1;b3738;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b3738;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0
AKGt2r;b3738;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b3738;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b3738;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b3738;;adp_c + 4.0 h_e + pi_c --> atp_c + h2o_c + 3.0 h_c;45.51400977451776;0.0
Biomass_Ecoli_core;b3738;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.3742298749331097
CO2t;b3738;;co2_e <=> co2_c;-22.809833310205086;0.0
CS;b3738;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;0.4037566120653314
CYTBD;b3738;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;14.584631748805457
D_LACt2;b3738;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b3738;;2pg_c <=> h2o_c + pep_c;14.716139568742859;18.445336830565385
ETOHt2r;b3738;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b3738;;ac_e --> ;0.0;14.312267245829124
EX_acald_e;b3738;;acald_e --> ;0.0;0.0
EX_akg_e;b3738;;akg_e --> ;0.0;0.0
EX_co2_e;b3738;;co2_e <=> ;22.809833310205086;0.0
EX_etoh_e;b3738;;etoh_e --> ;0.0;0.0
EX_for_e;b3738;;for_e --> ;0.0;15.44992606562578
EX_fru_e;b3738;;fru_e --> ;0.0;0.0
EX_fum_e;b3738;;fum_e --> ;0.0;0.0
EX_glc__D_e;b3738;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b3738;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b3738;;glu__L_e --> ;0.0;0.0
EX_h_e;b3738;;h_e <=> ;17.530865429786523;37.26924460261309
EX_h2o_e;b3738;;h2o_e <=> ;29.175827135565836;2.726040100962767
EX_lac__D_e;b3738;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b3738;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b3738;;nh4_e <=> ;-4.765319193197444;-2.04060066203526
EX_o2_e;b3738;;o2_e <=> ;-21.799492655998886;-7.292315874402727
EX_pi_e;b3738;;pi_e <=> ;-3.214895047684769;-1.3766794409164365
EX_pyr_e;b3738;;pyr_e --> ;0.0;0.0
EX_succ_e;b3738;;succ_e --> ;0.0;0.0
FBA;b3738;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;9.627753543404037
FBP;b3738;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b3738;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b3738;;for_c --> for_e;0.0;15.44992606562578
FRD7;b3738;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b3738;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b3738;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;0.0
FUMt2_2;b3738;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b3738;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;0.0
GAPD;b3738;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;19.005184723465316
GLCpts;b3738;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b3738;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.09569057902039614
GLNabc;b3738;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b3738;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-1.944910083014864
GLUN;b3738;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b3738;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b3738;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b3738;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;0.0
H2Ot;b3738;;h2o_e <=> h2o_c;-29.175827135565836;-2.726040100962767
ICDHyr;b3738;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.4037566120653315
ICL;b3738;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b3738;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b3738;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b3738;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b3738;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;0.0
ME1;b3738;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b3738;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b3738;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;14.584631748805455
NADTRHD;b3738;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b3738;;nh4_e <=> nh4_c;4.765319193197444;2.04060066203526
O2t;b3738;;o2_e <=> o2_c;21.799492655998886;7.292315874402727
PDH;b3738;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;0.6686365175429876
PFK;b3738;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;9.627753543404037
PFL;b3738;;coa_c + pyr_c --> accoa_c + for_c;0.0;15.44992606562578
PGI;b3738;;g6p_c <=> f6p_c;4.860861146496871;9.923282875638714
PGK;b3738;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-19.00518472346532
PGL;b3738;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;0.0
PGM;b3738;;2pg_c <=> 3pg_c;-14.716139568742859;-18.445336830565385
PIt2r;b3738;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;1.3766794409164365
PPC;b3738;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;1.072393129608319
PPCK;b3738;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b3738;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b3738;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;14.312267245829123
PYK;b3738;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;7.1786809728792855
PYRt2;b3738;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b3738;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;-0.2689964341019193
RPI;b3738;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-0.26899643410191926
SUCCt2_2;b3738;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;11.91877874304856
SUCCt3;b3738;;h_e + succ_c --> h_c + succ_e;0.0;11.91877874304856
SUCDi;b3738;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;0.0
SUCOAS;b3738;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;0.0
TALA;b3738;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;-0.06694972462553335
THD2;b3738;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;6.416582858590592
TKT1;b3738;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;-0.06694972462553334
TKT2;b3738;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;-0.20204670947638592
TPI;b3738;;dhap_c <=> g3p_c;7.477381962160304;9.627753543404037
ACALD;b3731;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b3731;;acald_e <=> acald_c;0.0;0.0
ACKr;b3731;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;-14.312267245829123
ACONTa;b3731;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;0.4037566120653314
ACONTb;b3731;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;0.4037566120653315
ACt2r;b3731;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;-14.312267245829124
ADK1;b3731;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b3731;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0
AKGt2r;b3731;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b3731;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b3731;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b3731;;adp_c + 4.0 h_e + pi_c --> atp_c + h2o_c + 3.0 h_c;45.51400977451776;0.0
Biomass_Ecoli_core;b3731;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.3742298749331097
CO2t;b3731;;co2_e <=> co2_c;-22.809833310205086;0.0
CS;b3731;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;0.4037566120653314
CYTBD;b3731;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;14.584631748805457
D_LACt2;b3731;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b3731;;2pg_c <=> h2o_c + pep_c;14.716139568742859;18.445336830565385
ETOHt2r;b3731;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b3731;;ac_e --> ;0.0;14.312267245829124
EX_acald_e;b3731;;acald_e --> ;0.0;0.0
EX_akg_e;b3731;;akg_e --> ;0.0;0.0
EX_co2_e;b3731;;co2_e <=> ;22.809833310205086;0.0
EX_etoh_e;b3731;;etoh_e --> ;0.0;0.0
EX_for_e;b3731;;for_e --> ;0.0;15.44992606562578
EX_fru_e;b3731;;fru_e --> ;0.0;0.0
EX_fum_e;b3731;;fum_e --> ;0.0;0.0
EX_glc__D_e;b3731;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b3731;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b3731;;glu__L_e --> ;0.0;0.0
EX_h_e;b3731;;h_e <=> ;17.530865429786523;37.26924460261309
EX_h2o_e;b3731;;h2o_e <=> ;29.175827135565836;2.726040100962767
EX_lac__D_e;b3731;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b3731;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b3731;;nh4_e <=> ;-4.765319193197444;-2.04060066203526
EX_o2_e;b3731;;o2_e <=> ;-21.799492655998886;-7.292315874402727
EX_pi_e;b3731;;pi_e <=> ;-3.214895047684769;-1.3766794409164365
EX_pyr_e;b3731;;pyr_e --> ;0.0;0.0
EX_succ_e;b3731;;succ_e --> ;0.0;0.0
FBA;b3731;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;9.627753543404037
FBP;b3731;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b3731;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b3731;;for_c --> for_e;0.0;15.44992606562578
FRD7;b3731;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b3731;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b3731;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;0.0
FUMt2_2;b3731;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b3731;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;0.0
GAPD;b3731;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;19.005184723465316
GLCpts;b3731;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b3731;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.09569057902039614
GLNabc;b3731;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b3731;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-1.944910083014864
GLUN;b3731;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b3731;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b3731;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b3731;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;0.0
H2Ot;b3731;;h2o_e <=> h2o_c;-29.175827135565836;-2.726040100962767
ICDHyr;b3731;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.4037566120653315
ICL;b3731;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b3731;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b3731;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b3731;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b3731;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;0.0
ME1;b3731;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b3731;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b3731;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;14.584631748805455
NADTRHD;b3731;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b3731;;nh4_e <=> nh4_c;4.765319193197444;2.04060066203526
O2t;b3731;;o2_e <=> o2_c;21.799492655998886;7.292315874402727
PDH;b3731;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;0.6686365175429876
PFK;b3731;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;9.627753543404037
PFL;b3731;;coa_c + pyr_c --> accoa_c + for_c;0.0;15.44992606562578
PGI;b3731;;g6p_c <=> f6p_c;4.860861146496871;9.923282875638714
PGK;b3731;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-19.00518472346532
PGL;b3731;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;0.0
PGM;b3731;;2pg_c <=> 3pg_c;-14.716139568742859;-18.445336830565385
PIt2r;b3731;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;1.3766794409164365
PPC;b3731;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;1.072393129608319
PPCK;b3731;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b3731;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b3731;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;14.312267245829123
PYK;b3731;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;7.1786809728792855
PYRt2;b3731;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b3731;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;-0.2689964341019193
RPI;b3731;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-0.26899643410191926
SUCCt2_2;b3731;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;11.91877874304856
SUCCt3;b3731;;h_e + succ_c --> h_c + succ_e;0.0;11.91877874304856
SUCDi;b3731;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;0.0
SUCOAS;b3731;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;0.0
TALA;b3731;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;-0.06694972462553335
THD2;b3731;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;6.416582858590592
TKT1;b3731;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;-0.06694972462553334
TKT2;b3731;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;-0.20204670947638592
TPI;b3731;;dhap_c <=> g3p_c;7.477381962160304;9.627753543404037
ACALD;b3737;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b3737;;acald_e <=> acald_c;0.0;0.0
ACKr;b3737;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;-14.312267245829123
ACONTa;b3737;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;0.4037566120653314
ACONTb;b3737;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;0.4037566120653315
ACt2r;b3737;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;-14.312267245829124
ADK1;b3737;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b3737;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0
AKGt2r;b3737;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b3737;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b3737;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b3737;;adp_c + 4.0 h_e + pi_c --> atp_c + h2o_c + 3.0 h_c;45.51400977451776;0.0
Biomass_Ecoli_core;b3737;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.3742298749331097
CO2t;b3737;;co2_e <=> co2_c;-22.809833310205086;0.0
CS;b3737;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;0.4037566120653314
CYTBD;b3737;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;14.584631748805457
D_LACt2;b3737;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b3737;;2pg_c <=> h2o_c + pep_c;14.716139568742859;18.445336830565385
ETOHt2r;b3737;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b3737;;ac_e --> ;0.0;14.312267245829124
EX_acald_e;b3737;;acald_e --> ;0.0;0.0
EX_akg_e;b3737;;akg_e --> ;0.0;0.0
EX_co2_e;b3737;;co2_e <=> ;22.809833310205086;0.0
EX_etoh_e;b3737;;etoh_e --> ;0.0;0.0
EX_for_e;b3737;;for_e --> ;0.0;15.44992606562578
EX_fru_e;b3737;;fru_e --> ;0.0;0.0
EX_fum_e;b3737;;fum_e --> ;0.0;0.0
EX_glc__D_e;b3737;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b3737;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b3737;;glu__L_e --> ;0.0;0.0
EX_h_e;b3737;;h_e <=> ;17.530865429786523;37.26924460261309
EX_h2o_e;b3737;;h2o_e <=> ;29.175827135565836;2.726040100962767
EX_lac__D_e;b3737;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b3737;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b3737;;nh4_e <=> ;-4.765319193197444;-2.04060066203526
EX_o2_e;b3737;;o2_e <=> ;-21.799492655998886;-7.292315874402727
EX_pi_e;b3737;;pi_e <=> ;-3.214895047684769;-1.3766794409164365
EX_pyr_e;b3737;;pyr_e --> ;0.0;0.0
EX_succ_e;b3737;;succ_e --> ;0.0;0.0
FBA;b3737;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;9.627753543404037
FBP;b3737;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b3737;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b3737;;for_c --> for_e;0.0;15.44992606562578
FRD7;b3737;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b3737;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b3737;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;0.0
FUMt2_2;b3737;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b3737;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;0.0
GAPD;b3737;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;19.005184723465316
GLCpts;b3737;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b3737;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.09569057902039614
GLNabc;b3737;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b3737;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-1.944910083014864
GLUN;b3737;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b3737;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b3737;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b3737;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;0.0
H2Ot;b3737;;h2o_e <=> h2o_c;-29.175827135565836;-2.726040100962767
ICDHyr;b3737;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.4037566120653315
ICL;b3737;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b3737;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b3737;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b3737;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b3737;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;0.0
ME1;b3737;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b3737;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b3737;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;14.584631748805455
NADTRHD;b3737;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b3737;;nh4_e <=> nh4_c;4.765319193197444;2.04060066203526
O2t;b3737;;o2_e <=> o2_c;21.799492655998886;7.292315874402727
PDH;b3737;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;0.6686365175429876
PFK;b3737;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;9.627753543404037
PFL;b3737;;coa_c + pyr_c --> accoa_c + for_c;0.0;15.44992606562578
PGI;b3737;;g6p_c <=> f6p_c;4.860861146496871;9.923282875638714
PGK;b3737;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-19.00518472346532
PGL;b3737;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;0.0
PGM;b3737;;2pg_c <=> 3pg_c;-14.716139568742859;-18.445336830565385
PIt2r;b3737;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;1.3766794409164365
PPC;b3737;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;1.072393129608319
PPCK;b3737;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b3737;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b3737;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;14.312267245829123
PYK;b3737;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;7.1786809728792855
PYRt2;b3737;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b3737;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;-0.2689964341019193
RPI;b3737;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-0.26899643410191926
SUCCt2_2;b3737;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;11.91877874304856
SUCCt3;b3737;;h_e + succ_c --> h_c + succ_e;0.0;11.91877874304856
SUCDi;b3737;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;0.0
SUCOAS;b3737;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;0.0
TALA;b3737;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;-0.06694972462553335
THD2;b3737;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;6.416582858590592
TKT1;b3737;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;-0.06694972462553334
TKT2;b3737;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;-0.20204670947638592
TPI;b3737;;dhap_c <=> g3p_c;7.477381962160304;9.627753543404037
ACALD;b3739;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b3739;;acald_e <=> acald_c;0.0;0.0
ACKr;b3739;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;9.254629107952257e-15
ACONTa;b3739;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.00724957535033
ACONTb;b3739;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350331
ACt2r;b3739;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b3739;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b3739;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b3739;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b3739;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b3739;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b3739;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517454
Biomass_Ecoli_core;b3739;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684303
CO2t;b3739;;co2_e <=> co2_c;-22.809833310205086;-22.809833310204958
CS;b3739;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.00724957535033
CYTBD;b3739;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199752
D_LACt2;b3739;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b3739;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.71613956874283
ETOHt2r;b3739;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b3739;;ac_e --> ;0.0;0.0
EX_acald_e;b3739;;acald_e --> ;0.0;0.0
EX_akg_e;b3739;;akg_e --> ;0.0;0.0
EX_co2_e;b3739;;co2_e <=> ;22.809833310205086;22.809833310204958
EX_etoh_e;b3739;;etoh_e --> ;0.0;0.0
EX_for_e;b3739;;for_e --> ;0.0;0.0
EX_fru_e;b3739;;fru_e --> ;0.0;0.0
EX_fum_e;b3739;;fum_e --> ;0.0;0.0
EX_glc__D_e;b3739;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b3739;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b3739;;glu__L_e --> ;0.0;0.0
EX_h_e;b3739;;h_e <=> ;17.530865429786523;17.530865429786697
EX_h2o_e;b3739;;h2o_e <=> ;29.175827135565836;29.175827135565818
EX_lac__D_e;b3739;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b3739;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b3739;;nh4_e <=> ;-4.765319193197444;-4.765319193197454
EX_o2_e;b3739;;o2_e <=> ;-21.799492655998886;-21.799492655998755
EX_pi_e;b3739;;pi_e <=> ;-3.214895047684769;-3.214895047684765
EX_pyr_e;b3739;;pyr_e --> ;0.0;0.0
EX_succ_e;b3739;;succ_e --> ;0.0;0.0
FBA;b3739;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160285
FBP;b3739;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b3739;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b3739;;for_c --> for_e;0.0;0.0
FRD7;b3739;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b3739;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b3739;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482092
FUMt2_2;b3739;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b3739;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b3739;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167604
GLCpts;b3739;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b3739;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.2234617293318274
GLNabc;b3739;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b3739;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.541857463865628
GLUN;b3739;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b3739;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b3739;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b3739;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b3739;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565818
ICDHyr;b3739;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350331
ICL;b3739;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b3739;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b3739;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b3739;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b3739;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482092
ME1;b3739;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b3739;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b3739;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.53460965051542
NADTRHD;b3739;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b3739;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197454
O2t;b3739;;o2_e <=> o2_c;21.799492655998886;21.799492655998755
PDH;b3739;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.282532599166615
PFK;b3739;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160285
PFL;b3739;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b3739;;g6p_c <=> f6p_c;4.860861146496871;4.86086114649682
PGK;b3739;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.023526143167608
PGL;b3739;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b3739;;2pg_c <=> 3pg_c;-14.716139568742859;-14.71613956874283
PIt2r;b3739;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684765
PPC;b3739;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.504309470368733
PPCK;b3739;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b3739;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b3739;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;-9.254629107952257e-15
PYK;b3739;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067854
PYRt2;b3739;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b3739;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507528
RPI;b3739;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671255
SUCCt2_2;b3739;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b3739;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b3739;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482093
SUCOAS;b3739;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482093
TALA;b3739;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b3739;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b3739;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b3739;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.1814980932459627
TPI;b3739;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160285
ACALD;b0720;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b0720;;acald_e <=> acald_c;0.0;0.0
ACKr;b0720;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;-20.00000000000002
ACONTa;b0720;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;0.0
ACONTb;b0720;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;0.0
ACt2r;b0720;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;-20.000000000000025
ADK1;b0720;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b0720;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0
AKGt2r;b0720;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b0720;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b0720;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;90.00000000000013
ATPS4r;b0720;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;50.00000000000003
Biomass_Ecoli_core;b0720;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;-5.395886756813222e-16
CO2t;b0720;;co2_e <=> co2_c;-22.809833310205086;-20.00000000000002
CS;b0720;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;0.0
CYTBD;b0720;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;40.00000000000003
D_LACt2;b0720;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b0720;;2pg_c <=> h2o_c + pep_c;14.716139568742859;20.000000000000007
ETOHt2r;b0720;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b0720;;ac_e --> ;0.0;20.000000000000025
EX_acald_e;b0720;;acald_e --> ;0.0;0.0
EX_akg_e;b0720;;akg_e --> ;0.0;0.0
EX_co2_e;b0720;;co2_e <=> ;22.809833310205086;20.00000000000002
EX_etoh_e;b0720;;etoh_e --> ;0.0;0.0
EX_for_e;b0720;;for_e --> ;0.0;0.0
EX_fru_e;b0720;;fru_e --> ;0.0;0.0
EX_fum_e;b0720;;fum_e --> ;0.0;0.0
EX_glc__D_e;b0720;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b0720;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b0720;;glu__L_e --> ;0.0;0.0
EX_h_e;b0720;;h_e <=> ;17.530865429786523;20.00000000000002
EX_h2o_e;b0720;;h2o_e <=> ;29.175827135565836;19.99999999999997
EX_lac__D_e;b0720;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b0720;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b0720;;nh4_e <=> ;-4.765319193197444;2.942269130755113e-15
EX_o2_e;b0720;;o2_e <=> ;-21.799492655998886;-20.00000000000001
EX_pi_e;b0720;;pi_e <=> ;-3.214895047684769;-4.60564284101701e-15
EX_pyr_e;b0720;;pyr_e --> ;0.0;0.0
EX_succ_e;b0720;;succ_e --> ;0.0;-7.63962187873116e-16
FBA;b0720;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;10.000000000000004
FBP;b0720;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b0720;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b0720;;for_c --> for_e;0.0;0.0
FRD7;b0720;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b0720;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b0720;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;3.0389888080807195e-15
FUMt2_2;b0720;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b0720;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;-4.9170018071460485e-15
GAPD;b0720;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;20.000000000000007
GLCpts;b0720;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b0720;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;-1.3797282437171408e-16
GLNabc;b0720;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b0720;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;2.804296306383399e-15
GLUN;b0720;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b0720;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b0720;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b0720;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;-4.917001807146048e-15
H2Ot;b0720;;h2o_e <=> h2o_c;-29.175827135565836;-19.99999999999997
ICDHyr;b0720;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.0
ICL;b0720;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b0720;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b0720;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b0720;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b0720;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;3.03898880808072e-15
ME1;b0720;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b0720;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b0720;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;40.00000000000002
NADTRHD;b0720;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b0720;;nh4_e <=> nh4_c;4.765319193197444;-2.942269130755113e-15
O2t;b0720;;o2_e <=> o2_c;21.799492655998886;20.00000000000001
PDH;b0720;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;20.000000000000018
PFK;b0720;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;10.000000000000004
PFL;b0720;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b0720;;g6p_c <=> f6p_c;4.860861146496871;10.000000000000007
PGK;b0720;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-20.00000000000001
PGL;b0720;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;-4.9170018071460485e-15
PGM;b0720;;2pg_c <=> 3pg_c;-14.716139568742859;-20.000000000000004
PIt2r;b0720;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;4.60564284101701e-15
PPC;b0720;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;-9.60794076238377e-15
PPCK;b0720;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b0720;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b0720;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;20.000000000000025
PYK;b0720;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;10.000000000000018
PYRt2;b0720;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b0720;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;-5.659747629010557e-15
RPI;b0720;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-7.427458218645089e-16
SUCCt2_2;b0720;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b0720;;h_e + succ_c --> h_c + succ_e;0.0;-7.63962187873116e-16
SUCDi;b0720;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;0.0
SUCOAS;b0720;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-2.275026620207604e-15
TALA;b0720;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;-4.312070952628888e-15
THD2;b0720;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b0720;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;-4.312070952628887e-15
TKT2;b0720;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;-1.34767667638167e-15
TPI;b0720;;dhap_c <=> g3p_c;7.477381962160304;10.000000000000004
ACALD;b0733;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b0733;;acald_e <=> acald_c;0.0;0.0
ACKr;b0733;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;1.7321003913454993e-15
ACONTa;b0733;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350328
ACONTb;b0733;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350328
ACt2r;b0733;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b0733;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b0733;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482086
AKGt2r;b0733;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b0733;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b0733;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b0733;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.51400977451739
Biomass_Ecoli_core;b0733;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.873921506968431
CO2t;b0733;;co2_e <=> co2_c;-22.809833310205086;-22.809833310204947
CS;b0733;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350327
CYTBD;b0733;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.5989853119975
D_LACt2;b0733;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b0733;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742829
ETOHt2r;b0733;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b0733;;ac_e --> ;0.0;0.0
EX_acald_e;b0733;;acald_e --> ;0.0;0.0
EX_akg_e;b0733;;akg_e --> ;0.0;0.0
EX_co2_e;b0733;;co2_e <=> ;22.809833310205086;22.809833310204947
EX_etoh_e;b0733;;etoh_e --> ;0.0;0.0
EX_for_e;b0733;;for_e --> ;0.0;0.0
EX_fru_e;b0733;;fru_e --> ;0.0;0.0
EX_fum_e;b0733;;fum_e --> ;0.0;0.0
EX_glc__D_e;b0733;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b0733;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b0733;;glu__L_e --> ;0.0;0.0
EX_h_e;b0733;;h_e <=> ;17.530865429786523;17.530865429786836
EX_h2o_e;b0733;;h2o_e <=> ;29.175827135565836;29.175827135565683
EX_lac__D_e;b0733;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b0733;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b0733;;nh4_e <=> ;-4.765319193197444;-4.76531919319746
EX_o2_e;b0733;;o2_e <=> ;-21.799492655998886;-21.799492655998748
EX_pi_e;b0733;;pi_e <=> ;-3.214895047684769;-3.214895047684807
EX_pyr_e;b0733;;pyr_e --> ;0.0;0.0
EX_succ_e;b0733;;succ_e --> ;0.0;0.0
FBA;b0733;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160281
FBP;b0733;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b0733;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b0733;;for_c --> for_e;0.0;0.0
FRD7;b0733;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b0733;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b0733;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482088
FUMt2_2;b0733;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b0733;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574665
GAPD;b0733;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.0235261431676
GLCpts;b0733;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b0733;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.2234617293318277
GLNabc;b0733;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b0733;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.541857463865632
GLUN;b0733;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b0733;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b0733;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b0733;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.959984944574664
H2Ot;b0733;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565683
ICDHyr;b0733;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350326
ICL;b0733;;icit_c --> glx_c + succ_c;0.0;4.1211941306032897e-16
LDH_D;b0733;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b0733;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b0733;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b0733;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482089
ME1;b0733;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b0733;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b0733;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.53460965051541
NADTRHD;b0733;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b0733;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197461
O2t;b0733;;o2_e <=> o2_c;21.799492655998886;21.799492655998748
PDH;b0733;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916661
PFK;b0733;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.4773819621602815
PFL;b0733;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b0733;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496808
PGK;b0733;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.023526143167604
PGL;b0733;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574665
PGM;b0733;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742829
PIt2r;b0733;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684807
PPC;b0733;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687365
PPCK;b0733;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b0733;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b0733;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;-1.7321003913454993e-15
PYK;b0733;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067786
PYRt2;b0733;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b0733;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.6784818505075343
RPI;b0733;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.28150309406713
SUCCt2_2;b0733;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b0733;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b0733;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482088
SUCOAS;b0733;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482087
TALA;b0733;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615692
THD2;b0733;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b0733;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.496983757261569
TKT2;b0733;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.1814980932459656
TPI;b0733;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160281
ACALD;b0979;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b0979;;acald_e <=> acald_c;0.0;0.0
ACKr;b0979;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b0979;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b0979;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b0979;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b0979;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b0979;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b0979;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b0979;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b0979;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b0979;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b0979;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b0979;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b0979;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b0979;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b0979;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b0979;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b0979;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b0979;;ac_e --> ;0.0;0.0
EX_acald_e;b0979;;acald_e --> ;0.0;0.0
EX_akg_e;b0979;;akg_e --> ;0.0;0.0
EX_co2_e;b0979;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b0979;;etoh_e --> ;0.0;0.0
EX_for_e;b0979;;for_e --> ;0.0;0.0
EX_fru_e;b0979;;fru_e --> ;0.0;0.0
EX_fum_e;b0979;;fum_e --> ;0.0;0.0
EX_glc__D_e;b0979;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b0979;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b0979;;glu__L_e --> ;0.0;0.0
EX_h_e;b0979;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b0979;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b0979;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b0979;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b0979;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b0979;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b0979;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b0979;;pyr_e --> ;0.0;0.0
EX_succ_e;b0979;;succ_e --> ;0.0;0.0
FBA;b0979;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b0979;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b0979;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b0979;;for_c --> for_e;0.0;0.0
FRD7;b0979;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b0979;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b0979;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b0979;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b0979;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b0979;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b0979;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b0979;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b0979;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b0979;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b0979;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b0979;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b0979;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b0979;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b0979;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b0979;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b0979;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b0979;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b0979;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b0979;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b0979;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b0979;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b0979;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b0979;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b0979;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b0979;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b0979;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b0979;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b0979;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b0979;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b0979;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b0979;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b0979;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b0979;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b0979;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b0979;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b0979;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b0979;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b0979;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b0979;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b0979;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b0979;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b0979;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b0979;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b0979;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b0979;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b0979;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b0979;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b0979;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b0979;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b0979;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b0979;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b0978;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b0978;;acald_e <=> acald_c;0.0;0.0
ACKr;b0978;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b0978;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b0978;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b0978;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b0978;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b0978;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b0978;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b0978;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b0978;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b0978;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b0978;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b0978;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b0978;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b0978;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b0978;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b0978;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b0978;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b0978;;ac_e --> ;0.0;0.0
EX_acald_e;b0978;;acald_e --> ;0.0;0.0
EX_akg_e;b0978;;akg_e --> ;0.0;0.0
EX_co2_e;b0978;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b0978;;etoh_e --> ;0.0;0.0
EX_for_e;b0978;;for_e --> ;0.0;0.0
EX_fru_e;b0978;;fru_e --> ;0.0;0.0
EX_fum_e;b0978;;fum_e --> ;0.0;0.0
EX_glc__D_e;b0978;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b0978;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b0978;;glu__L_e --> ;0.0;0.0
EX_h_e;b0978;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b0978;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b0978;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b0978;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b0978;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b0978;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b0978;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b0978;;pyr_e --> ;0.0;0.0
EX_succ_e;b0978;;succ_e --> ;0.0;0.0
FBA;b0978;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b0978;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b0978;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b0978;;for_c --> for_e;0.0;0.0
FRD7;b0978;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b0978;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b0978;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b0978;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b0978;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b0978;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b0978;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b0978;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b0978;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b0978;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b0978;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b0978;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b0978;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b0978;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b0978;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b0978;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b0978;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b0978;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b0978;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b0978;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b0978;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b0978;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b0978;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b0978;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b0978;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b0978;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b0978;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b0978;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b0978;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b0978;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b0978;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b0978;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b0978;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b0978;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b0978;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b0978;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b0978;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b0978;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b0978;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b0978;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b0978;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b0978;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b0978;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b0978;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b0978;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b0978;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b0978;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b0978;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b0978;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b0978;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b0978;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b0978;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b0734;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b0734;;acald_e <=> acald_c;0.0;0.0
ACKr;b0734;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b0734;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b0734;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b0734;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b0734;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b0734;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b0734;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b0734;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b0734;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b0734;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b0734;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b0734;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b0734;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b0734;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b0734;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b0734;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b0734;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b0734;;ac_e --> ;0.0;0.0
EX_acald_e;b0734;;acald_e --> ;0.0;0.0
EX_akg_e;b0734;;akg_e --> ;0.0;0.0
EX_co2_e;b0734;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b0734;;etoh_e --> ;0.0;0.0
EX_for_e;b0734;;for_e --> ;0.0;0.0
EX_fru_e;b0734;;fru_e --> ;0.0;0.0
EX_fum_e;b0734;;fum_e --> ;0.0;0.0
EX_glc__D_e;b0734;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b0734;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b0734;;glu__L_e --> ;0.0;0.0
EX_h_e;b0734;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b0734;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b0734;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b0734;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b0734;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b0734;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b0734;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b0734;;pyr_e --> ;0.0;0.0
EX_succ_e;b0734;;succ_e --> ;0.0;0.0
FBA;b0734;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b0734;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b0734;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b0734;;for_c --> for_e;0.0;0.0
FRD7;b0734;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b0734;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b0734;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b0734;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b0734;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b0734;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b0734;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b0734;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b0734;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b0734;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b0734;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b0734;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b0734;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b0734;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b0734;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b0734;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b0734;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b0734;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b0734;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b0734;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b0734;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b0734;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b0734;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b0734;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b0734;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b0734;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b0734;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b0734;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b0734;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b0734;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b0734;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b0734;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b0734;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b0734;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b0734;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b0734;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b0734;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b0734;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b0734;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b0734;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b0734;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b0734;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b0734;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b0734;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b0734;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b0734;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b0734;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b0734;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b0734;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b0734;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b0734;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b0734;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b2975;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b2975;;acald_e <=> acald_c;0.0;0.0
ACKr;b2975;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b2975;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b2975;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b2975;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b2975;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b2975;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b2975;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b2975;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b2975;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b2975;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b2975;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b2975;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b2975;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b2975;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b2975;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b2975;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b2975;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b2975;;ac_e --> ;0.0;0.0
EX_acald_e;b2975;;acald_e --> ;0.0;0.0
EX_akg_e;b2975;;akg_e --> ;0.0;0.0
EX_co2_e;b2975;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b2975;;etoh_e --> ;0.0;0.0
EX_for_e;b2975;;for_e --> ;0.0;0.0
EX_fru_e;b2975;;fru_e --> ;0.0;0.0
EX_fum_e;b2975;;fum_e --> ;0.0;0.0
EX_glc__D_e;b2975;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b2975;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b2975;;glu__L_e --> ;0.0;0.0
EX_h_e;b2975;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b2975;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b2975;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b2975;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b2975;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b2975;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b2975;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b2975;;pyr_e --> ;0.0;0.0
EX_succ_e;b2975;;succ_e --> ;0.0;0.0
FBA;b2975;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b2975;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b2975;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b2975;;for_c --> for_e;0.0;0.0
FRD7;b2975;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b2975;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b2975;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b2975;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b2975;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b2975;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b2975;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b2975;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b2975;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b2975;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b2975;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b2975;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b2975;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b2975;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b2975;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b2975;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b2975;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b2975;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b2975;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b2975;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b2975;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b2975;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b2975;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b2975;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b2975;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b2975;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b2975;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b2975;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b2975;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b2975;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b2975;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b2975;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b2975;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b2975;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b2975;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b2975;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b2975;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b2975;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b2975;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b2975;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b2975;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b2975;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b2975;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b2975;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b2975;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b2975;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b2975;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b2975;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b2975;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b2975;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b2975;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b2975;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b3603;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b3603;;acald_e <=> acald_c;0.0;0.0
ACKr;b3603;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b3603;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b3603;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b3603;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b3603;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b3603;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b3603;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b3603;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b3603;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b3603;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b3603;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b3603;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b3603;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b3603;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b3603;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b3603;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b3603;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b3603;;ac_e --> ;0.0;0.0
EX_acald_e;b3603;;acald_e --> ;0.0;0.0
EX_akg_e;b3603;;akg_e --> ;0.0;0.0
EX_co2_e;b3603;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b3603;;etoh_e --> ;0.0;0.0
EX_for_e;b3603;;for_e --> ;0.0;0.0
EX_fru_e;b3603;;fru_e --> ;0.0;0.0
EX_fum_e;b3603;;fum_e --> ;0.0;0.0
EX_glc__D_e;b3603;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b3603;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b3603;;glu__L_e --> ;0.0;0.0
EX_h_e;b3603;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b3603;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b3603;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b3603;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b3603;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b3603;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b3603;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b3603;;pyr_e --> ;0.0;0.0
EX_succ_e;b3603;;succ_e --> ;0.0;0.0
FBA;b3603;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b3603;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b3603;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b3603;;for_c --> for_e;0.0;0.0
FRD7;b3603;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b3603;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b3603;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b3603;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b3603;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b3603;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b3603;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b3603;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b3603;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b3603;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b3603;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b3603;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b3603;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b3603;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b3603;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b3603;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b3603;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b3603;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b3603;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b3603;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b3603;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b3603;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b3603;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b3603;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b3603;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b3603;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b3603;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b3603;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b3603;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b3603;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b3603;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b3603;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b3603;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b3603;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b3603;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b3603;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b3603;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b3603;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b3603;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b3603;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b3603;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b3603;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b3603;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b3603;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b3603;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b3603;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b3603;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b3603;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b3603;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b3603;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b3603;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b3603;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b2779;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b2779;;acald_e <=> acald_c;0.0;0.0
ACKr;b2779;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b2779;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;-3.791374141075912e-15
ACONTb;b2779;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;-3.791374141075912e-15
ACt2r;b2779;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b2779;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.6453846153846249
AKGDH;b2779;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0
AKGt2r;b2779;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b2779;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b2779;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b2779;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;9.680769230769343
Biomass_Ecoli_core;b2779;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;1.5208622319983277e-15
CO2t;b2779;;co2_e <=> co2_c;-22.809833310205086;-3.8723076923077517
CS;b2779;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;-3.791374141075912e-15
CYTBD;b2779;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;7.744615384615493
D_LACt2;b2779;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b2779;;2pg_c --> h2o_c + pep_c;14.716139568742859;0.0
ETOHt2r;b2779;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b2779;;ac_e --> ;0.0;0.0
EX_acald_e;b2779;;acald_e --> ;0.0;0.0
EX_akg_e;b2779;;akg_e --> ;0.0;0.0
EX_co2_e;b2779;;co2_e <=> ;22.809833310205086;3.8723076923077517
EX_etoh_e;b2779;;etoh_e --> ;0.0;0.0
EX_for_e;b2779;;for_e --> ;0.0;0.0
EX_fru_e;b2779;;fru_e --> ;0.0;0.0
EX_fum_e;b2779;;fum_e --> ;0.0;0.0
EX_glc__D_e;b2779;;glc__D_e <=> ;-10.0;-0.6453846153846285
EX_gln__L_e;b2779;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b2779;;glu__L_e --> ;0.0;0.0
EX_h_e;b2779;;h_e <=> ;17.530865429786523;1.2297753566676806e-14
EX_h2o_e;b2779;;h2o_e <=> ;29.175827135565836;3.872307692307758
EX_lac__D_e;b2779;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b2779;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b2779;;nh4_e <=> ;-4.765319193197444;-1.0039929875026324e-14
EX_o2_e;b2779;;o2_e <=> ;-21.799492655998886;-3.872307692307746
EX_pi_e;b2779;;pi_e <=> ;-3.214895047684769;-6.966034797038227e-14
EX_pyr_e;b2779;;pyr_e --> ;0.0;0.0
EX_succ_e;b2779;;succ_e --> ;0.0;0.0
FBA;b2779;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;-0.6453846153846229
FBP;b2779;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.6453846153846228
FORt2;b2779;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b2779;;for_c --> for_e;0.0;0.0
FRD7;b2779;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b2779;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b2779;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;1.0811527192255712e-15
FUMt2_2;b2779;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b2779;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;3.8723076923077535
GAPD;b2779;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;4.7992287954955166e-15
GLCpts;b2779;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;0.6453846153846289
GLNS;b2779;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;3.8888447272197235e-16
GLNabc;b2779;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b2779;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-7.904073105918508e-15
GLUN;b2779;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b2779;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b2779;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b2779;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;3.872307692307753
H2Ot;b2779;;h2o_e <=> h2o_c;-29.175827135565836;-3.872307692307758
ICDHyr;b2779;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;-1.9995554722307993e-16
ICL;b2779;;icit_c --> glx_c + succ_c;0.0;-3.591418593852833e-15
LDH_D;b2779;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b2779;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;-3.591418593852833e-15
MALt2_2;b2779;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b2779;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;-2.5102658746272617e-15
ME1;b2779;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b2779;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b2779;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;7.744615384615491
NADTRHD;b2779;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;7.744615384615479
NH4t;b2779;;nh4_e <=> nh4_c;4.765319193197444;7.149316221901999e-15
O2t;b2779;;o2_e <=> o2_c;21.799492655998886;3.872307692307746
PDH;b2779;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;0.0
PFK;b2779;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;0.0
PFL;b2779;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b2779;;g6p_c <=> f6p_c;4.860861146496871;-3.2269230769231245
PGK;b2779;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-4.799228795495517e-15
PGL;b2779;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;3.872307692307754
PGM;b2779;;2pg_c <=> 3pg_c;-14.716139568742859;0.0
PIt2r;b2779;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;6.966034797038227e-14
PPC;b2779;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;0.0
PPCK;b2779;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;-1.8273994358831978e-15
PPS;b2779;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.6453846153846249
PTAr;b2779;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b2779;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;0.0
PYRt2;b2779;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b2779;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.5815384615385004
RPI;b2779;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-1.2907692307692535
SUCCt2_2;b2779;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b2779;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b2779;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;1.081152719225571e-15
SUCOAS;b2779;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-4.672571313078404e-15
TALA;b2779;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.2907692307692507
THD2;b2779;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b2779;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.2907692307692504
TKT2;b2779;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.2907692307692502
TPI;b2779;;dhap_c <=> g3p_c;7.477381962160304;-0.6453846153846229
ACALD;b1773;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b1773;;acald_e <=> acald_c;0.0;0.0
ACKr;b1773;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b1773;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350336
ACONTb;b1773;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350336
ACt2r;b1773;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b1773;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b1773;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482088
AKGt2r;b1773;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b1773;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b1773;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b1773;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.51400977451744
Biomass_Ecoli_core;b1773;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684303
CO2t;b1773;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020496
CS;b1773;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350335
CYTBD;b1773;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b1773;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b1773;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742843
ETOHt2r;b1773;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b1773;;ac_e --> ;0.0;0.0
EX_acald_e;b1773;;acald_e --> ;0.0;0.0
EX_akg_e;b1773;;akg_e --> ;0.0;0.0
EX_co2_e;b1773;;co2_e <=> ;22.809833310205086;22.80983331020496
EX_etoh_e;b1773;;etoh_e --> ;0.0;0.0
EX_for_e;b1773;;for_e --> ;0.0;0.0
EX_fru_e;b1773;;fru_e --> ;0.0;0.0
EX_fum_e;b1773;;fum_e --> ;0.0;0.0
EX_glc__D_e;b1773;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b1773;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b1773;;glu__L_e --> ;0.0;0.0
EX_h_e;b1773;;h_e <=> ;17.530865429786523;17.530865429786765
EX_h2o_e;b1773;;h2o_e <=> ;29.175827135565836;29.175827135565793
EX_lac__D_e;b1773;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b1773;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b1773;;nh4_e <=> ;-4.765319193197444;-4.765319193197456
EX_o2_e;b1773;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b1773;;pi_e <=> ;-3.214895047684769;-3.2148950476848017
EX_pyr_e;b1773;;pyr_e --> ;0.0;0.0
EX_succ_e;b1773;;succ_e --> ;0.0;0.0
FBA;b1773;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160275
FBP;b1773;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b1773;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b1773;;for_c --> for_e;0.0;0.0
FRD7;b1773;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b1773;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b1773;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482089
FUMt2_2;b1773;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b1773;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574667
GAPD;b1773;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.02352614316762
GLCpts;b1773;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000009
GLNS;b1773;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.2234617293318276
GLNabc;b1773;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b1773;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.541857463865629
GLUN;b1773;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b1773;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b1773;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b1773;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.959984944574666
H2Ot;b1773;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565793
ICDHyr;b1773;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350326
ICL;b1773;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b1773;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b1773;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b1773;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b1773;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482089
ME1;b1773;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b1773;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b1773;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b1773;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b1773;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197456
O2t;b1773;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b1773;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.282532599166618
PFK;b1773;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160288
PFL;b1773;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b1773;;g6p_c <=> f6p_c;4.860861146496871;4.8608611464968225
PGK;b1773;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.023526143167615
PGL;b1773;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574667
PGM;b1773;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742843
PIt2r;b1773;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.2148950476848017
PPC;b1773;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.504309470368739
PPCK;b1773;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b1773;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b1773;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b1773;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067786
PYRt2;b1773;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b1773;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507536
RPI;b1773;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671304
SUCCt2_2;b1773;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b1773;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b1773;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482089
SUCOAS;b1773;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482089
TALA;b1773;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615698
THD2;b1773;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b1773;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615696
TKT2;b1773;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.1814980932459664
TPI;b1773;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160275
ACALD;b2925;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b2925;;acald_e <=> acald_c;0.0;0.0
ACKr;b2925;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b2925;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b2925;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b2925;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b2925;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b2925;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b2925;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b2925;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b2925;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b2925;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b2925;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b2925;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b2925;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b2925;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b2925;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b2925;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b2925;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b2925;;ac_e --> ;0.0;0.0
EX_acald_e;b2925;;acald_e --> ;0.0;0.0
EX_akg_e;b2925;;akg_e --> ;0.0;0.0
EX_co2_e;b2925;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b2925;;etoh_e --> ;0.0;0.0
EX_for_e;b2925;;for_e --> ;0.0;0.0
EX_fru_e;b2925;;fru_e --> ;0.0;0.0
EX_fum_e;b2925;;fum_e --> ;0.0;0.0
EX_glc__D_e;b2925;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b2925;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b2925;;glu__L_e --> ;0.0;0.0
EX_h_e;b2925;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b2925;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b2925;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b2925;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b2925;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b2925;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b2925;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b2925;;pyr_e --> ;0.0;0.0
EX_succ_e;b2925;;succ_e --> ;0.0;0.0
FBA;b2925;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b2925;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b2925;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b2925;;for_c --> for_e;0.0;0.0
FRD7;b2925;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b2925;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b2925;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b2925;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b2925;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b2925;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b2925;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b2925;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b2925;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b2925;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b2925;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b2925;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b2925;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b2925;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b2925;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b2925;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b2925;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b2925;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b2925;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b2925;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b2925;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b2925;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b2925;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b2925;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b2925;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b2925;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b2925;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b2925;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b2925;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b2925;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b2925;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b2925;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b2925;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b2925;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b2925;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b2925;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b2925;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b2925;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b2925;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b2925;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b2925;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b2925;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b2925;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b2925;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b2925;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b2925;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b2925;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b2925;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b2925;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b2925;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b2925;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b2925;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b2097;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b2097;;acald_e <=> acald_c;0.0;0.0
ACKr;b2097;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b2097;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b2097;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b2097;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b2097;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b2097;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b2097;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b2097;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b2097;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b2097;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b2097;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b2097;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b2097;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b2097;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b2097;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b2097;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b2097;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b2097;;ac_e --> ;0.0;0.0
EX_acald_e;b2097;;acald_e --> ;0.0;0.0
EX_akg_e;b2097;;akg_e --> ;0.0;0.0
EX_co2_e;b2097;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b2097;;etoh_e --> ;0.0;0.0
EX_for_e;b2097;;for_e --> ;0.0;0.0
EX_fru_e;b2097;;fru_e --> ;0.0;0.0
EX_fum_e;b2097;;fum_e --> ;0.0;0.0
EX_glc__D_e;b2097;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b2097;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b2097;;glu__L_e --> ;0.0;0.0
EX_h_e;b2097;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b2097;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b2097;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b2097;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b2097;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b2097;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b2097;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b2097;;pyr_e --> ;0.0;0.0
EX_succ_e;b2097;;succ_e --> ;0.0;0.0
FBA;b2097;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b2097;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b2097;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b2097;;for_c --> for_e;0.0;0.0
FRD7;b2097;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b2097;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b2097;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b2097;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b2097;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b2097;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b2097;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b2097;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b2097;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b2097;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b2097;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b2097;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b2097;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b2097;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b2097;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b2097;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b2097;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b2097;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b2097;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b2097;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b2097;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b2097;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b2097;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b2097;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b2097;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b2097;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b2097;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b2097;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b2097;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b2097;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b2097;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b2097;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b2097;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b2097;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b2097;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b2097;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b2097;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b2097;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b2097;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b2097;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b2097;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b2097;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b2097;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b2097;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b2097;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b2097;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b2097;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b2097;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b2097;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b2097;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b2097;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b2097;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b4232;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b4232;;acald_e <=> acald_c;0.0;0.0
ACKr;b4232;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b4232;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b4232;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b4232;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b4232;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b4232;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b4232;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b4232;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b4232;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b4232;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b4232;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b4232;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b4232;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b4232;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b4232;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b4232;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b4232;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b4232;;ac_e --> ;0.0;0.0
EX_acald_e;b4232;;acald_e --> ;0.0;0.0
EX_akg_e;b4232;;akg_e --> ;0.0;0.0
EX_co2_e;b4232;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b4232;;etoh_e --> ;0.0;0.0
EX_for_e;b4232;;for_e --> ;0.0;0.0
EX_fru_e;b4232;;fru_e --> ;0.0;0.0
EX_fum_e;b4232;;fum_e --> ;0.0;0.0
EX_glc__D_e;b4232;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b4232;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b4232;;glu__L_e --> ;0.0;0.0
EX_h_e;b4232;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b4232;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b4232;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b4232;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b4232;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b4232;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b4232;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b4232;;pyr_e --> ;0.0;0.0
EX_succ_e;b4232;;succ_e --> ;0.0;0.0
FBA;b4232;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b4232;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b4232;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b4232;;for_c --> for_e;0.0;0.0
FRD7;b4232;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b4232;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b4232;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b4232;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b4232;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b4232;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b4232;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b4232;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b4232;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b4232;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b4232;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b4232;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b4232;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b4232;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b4232;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b4232;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b4232;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b4232;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b4232;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b4232;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b4232;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b4232;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b4232;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b4232;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b4232;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b4232;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b4232;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b4232;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b4232;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b4232;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b4232;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b4232;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b4232;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b4232;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b4232;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b4232;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b4232;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b4232;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b4232;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b4232;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b4232;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b4232;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b4232;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b4232;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b4232;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b4232;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b4232;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b4232;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b4232;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b4232;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b4232;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b4232;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b3925;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b3925;;acald_e <=> acald_c;0.0;0.0
ACKr;b3925;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b3925;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b3925;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b3925;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b3925;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b3925;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b3925;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b3925;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b3925;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b3925;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b3925;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b3925;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b3925;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b3925;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b3925;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b3925;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b3925;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b3925;;ac_e --> ;0.0;0.0
EX_acald_e;b3925;;acald_e --> ;0.0;0.0
EX_akg_e;b3925;;akg_e --> ;0.0;0.0
EX_co2_e;b3925;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b3925;;etoh_e --> ;0.0;0.0
EX_for_e;b3925;;for_e --> ;0.0;0.0
EX_fru_e;b3925;;fru_e --> ;0.0;0.0
EX_fum_e;b3925;;fum_e --> ;0.0;0.0
EX_glc__D_e;b3925;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b3925;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b3925;;glu__L_e --> ;0.0;0.0
EX_h_e;b3925;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b3925;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b3925;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b3925;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b3925;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b3925;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b3925;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b3925;;pyr_e --> ;0.0;0.0
EX_succ_e;b3925;;succ_e --> ;0.0;0.0
FBA;b3925;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b3925;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b3925;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b3925;;for_c --> for_e;0.0;0.0
FRD7;b3925;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b3925;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b3925;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b3925;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b3925;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b3925;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b3925;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b3925;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b3925;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b3925;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b3925;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b3925;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b3925;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b3925;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b3925;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b3925;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b3925;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b3925;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b3925;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b3925;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b3925;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b3925;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b3925;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b3925;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b3925;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b3925;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b3925;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b3925;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b3925;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b3925;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b3925;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b3925;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b3925;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b3925;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b3925;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b3925;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b3925;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b3925;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b3925;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b3925;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b3925;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b3925;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b3925;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b3925;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b3925;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b3925;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b3925;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b3925;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b3925;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b3925;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b3925;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b3925;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b0904;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b0904;;acald_e <=> acald_c;0.0;0.0
ACKr;b0904;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b0904;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b0904;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b0904;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b0904;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b0904;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b0904;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b0904;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b0904;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b0904;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b0904;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b0904;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b0904;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b0904;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b0904;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b0904;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b0904;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b0904;;ac_e --> ;0.0;0.0
EX_acald_e;b0904;;acald_e --> ;0.0;0.0
EX_akg_e;b0904;;akg_e --> ;0.0;0.0
EX_co2_e;b0904;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b0904;;etoh_e --> ;0.0;0.0
EX_for_e;b0904;;for_e --> ;0.0;0.0
EX_fru_e;b0904;;fru_e --> ;0.0;0.0
EX_fum_e;b0904;;fum_e --> ;0.0;0.0
EX_glc__D_e;b0904;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b0904;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b0904;;glu__L_e --> ;0.0;0.0
EX_h_e;b0904;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b0904;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b0904;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b0904;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b0904;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b0904;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b0904;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b0904;;pyr_e --> ;0.0;0.0
EX_succ_e;b0904;;succ_e --> ;0.0;0.0
FBA;b0904;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b0904;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b0904;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b0904;;for_c --> for_e;0.0;0.0
FRD7;b0904;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b0904;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b0904;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b0904;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b0904;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b0904;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b0904;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b0904;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b0904;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b0904;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b0904;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b0904;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b0904;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b0904;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b0904;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b0904;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b0904;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b0904;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b0904;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b0904;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b0904;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b0904;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b0904;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b0904;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b0904;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b0904;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b0904;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b0904;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b0904;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b0904;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b0904;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b0904;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b0904;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b0904;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b0904;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b0904;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b0904;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b0904;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b0904;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b0904;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b0904;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b0904;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b0904;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b0904;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b0904;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b0904;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b0904;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b0904;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b0904;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b0904;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b0904;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b0904;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b2492;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b2492;;acald_e <=> acald_c;0.0;0.0
ACKr;b2492;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b2492;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b2492;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b2492;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b2492;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b2492;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b2492;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b2492;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b2492;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b2492;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b2492;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b2492;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b2492;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b2492;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b2492;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b2492;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b2492;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b2492;;ac_e --> ;0.0;0.0
EX_acald_e;b2492;;acald_e --> ;0.0;0.0
EX_akg_e;b2492;;akg_e --> ;0.0;0.0
EX_co2_e;b2492;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b2492;;etoh_e --> ;0.0;0.0
EX_for_e;b2492;;for_e --> ;0.0;0.0
EX_fru_e;b2492;;fru_e --> ;0.0;0.0
EX_fum_e;b2492;;fum_e --> ;0.0;0.0
EX_glc__D_e;b2492;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b2492;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b2492;;glu__L_e --> ;0.0;0.0
EX_h_e;b2492;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b2492;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b2492;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b2492;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b2492;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b2492;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b2492;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b2492;;pyr_e --> ;0.0;0.0
EX_succ_e;b2492;;succ_e --> ;0.0;0.0
FBA;b2492;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b2492;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b2492;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b2492;;for_c --> for_e;0.0;0.0
FRD7;b2492;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b2492;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b2492;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b2492;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b2492;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b2492;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b2492;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b2492;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b2492;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b2492;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b2492;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b2492;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b2492;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b2492;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b2492;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b2492;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b2492;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b2492;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b2492;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b2492;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b2492;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b2492;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b2492;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b2492;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b2492;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b2492;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b2492;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b2492;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b2492;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b2492;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b2492;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b2492;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b2492;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b2492;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b2492;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b2492;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b2492;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b2492;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b2492;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b2492;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b2492;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b2492;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b2492;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b2492;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b2492;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b2492;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b2492;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b2492;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b2492;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b2492;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b2492;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b2492;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b4154;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b4154;;acald_e <=> acald_c;0.0;0.0
ACKr;b4154;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b4154;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b4154;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b4154;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b4154;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b4154;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b4154;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b4154;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b4154;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b4154;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b4154;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b4154;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b4154;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b4154;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b4154;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b4154;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b4154;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b4154;;ac_e --> ;0.0;0.0
EX_acald_e;b4154;;acald_e --> ;0.0;0.0
EX_akg_e;b4154;;akg_e --> ;0.0;0.0
EX_co2_e;b4154;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b4154;;etoh_e --> ;0.0;0.0
EX_for_e;b4154;;for_e --> ;0.0;0.0
EX_fru_e;b4154;;fru_e --> ;0.0;0.0
EX_fum_e;b4154;;fum_e --> ;0.0;0.0
EX_glc__D_e;b4154;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b4154;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b4154;;glu__L_e --> ;0.0;0.0
EX_h_e;b4154;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b4154;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b4154;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b4154;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b4154;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b4154;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b4154;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b4154;;pyr_e --> ;0.0;0.0
EX_succ_e;b4154;;succ_e --> ;0.0;0.0
FBA;b4154;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b4154;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b4154;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b4154;;for_c --> for_e;0.0;0.0
FRD7;b4154;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b4154;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b4154;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b4154;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b4154;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b4154;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b4154;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b4154;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b4154;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b4154;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b4154;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b4154;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b4154;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b4154;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b4154;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b4154;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b4154;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b4154;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b4154;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b4154;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b4154;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b4154;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b4154;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b4154;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b4154;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b4154;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b4154;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b4154;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b4154;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b4154;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b4154;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b4154;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b4154;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b4154;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b4154;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b4154;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b4154;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b4154;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b4154;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b4154;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b4154;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b4154;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b4154;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b4154;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b4154;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b4154;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b4154;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b4154;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b4154;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b4154;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b4154;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b4154;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b4152;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b4152;;acald_e <=> acald_c;0.0;0.0
ACKr;b4152;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b4152;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b4152;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b4152;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b4152;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b4152;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b4152;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b4152;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b4152;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b4152;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b4152;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b4152;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b4152;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b4152;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b4152;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b4152;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b4152;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b4152;;ac_e --> ;0.0;0.0
EX_acald_e;b4152;;acald_e --> ;0.0;0.0
EX_akg_e;b4152;;akg_e --> ;0.0;0.0
EX_co2_e;b4152;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b4152;;etoh_e --> ;0.0;0.0
EX_for_e;b4152;;for_e --> ;0.0;0.0
EX_fru_e;b4152;;fru_e --> ;0.0;0.0
EX_fum_e;b4152;;fum_e --> ;0.0;0.0
EX_glc__D_e;b4152;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b4152;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b4152;;glu__L_e --> ;0.0;0.0
EX_h_e;b4152;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b4152;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b4152;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b4152;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b4152;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b4152;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b4152;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b4152;;pyr_e --> ;0.0;0.0
EX_succ_e;b4152;;succ_e --> ;0.0;0.0
FBA;b4152;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b4152;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b4152;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b4152;;for_c --> for_e;0.0;0.0
FRD7;b4152;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b4152;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b4152;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b4152;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b4152;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b4152;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b4152;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b4152;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b4152;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b4152;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b4152;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b4152;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b4152;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b4152;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b4152;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b4152;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b4152;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b4152;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b4152;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b4152;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b4152;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b4152;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b4152;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b4152;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b4152;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b4152;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b4152;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b4152;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b4152;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b4152;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b4152;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b4152;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b4152;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b4152;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b4152;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b4152;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b4152;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b4152;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b4152;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b4152;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b4152;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b4152;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b4152;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b4152;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b4152;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b4152;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b4152;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b4152;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b4152;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b4152;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b4152;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b4152;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b4153;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b4153;;acald_e <=> acald_c;0.0;0.0
ACKr;b4153;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b4153;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b4153;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b4153;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b4153;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b4153;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b4153;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b4153;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b4153;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b4153;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b4153;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b4153;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b4153;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b4153;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b4153;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b4153;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b4153;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b4153;;ac_e --> ;0.0;0.0
EX_acald_e;b4153;;acald_e --> ;0.0;0.0
EX_akg_e;b4153;;akg_e --> ;0.0;0.0
EX_co2_e;b4153;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b4153;;etoh_e --> ;0.0;0.0
EX_for_e;b4153;;for_e --> ;0.0;0.0
EX_fru_e;b4153;;fru_e --> ;0.0;0.0
EX_fum_e;b4153;;fum_e --> ;0.0;0.0
EX_glc__D_e;b4153;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b4153;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b4153;;glu__L_e --> ;0.0;0.0
EX_h_e;b4153;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b4153;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b4153;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b4153;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b4153;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b4153;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b4153;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b4153;;pyr_e --> ;0.0;0.0
EX_succ_e;b4153;;succ_e --> ;0.0;0.0
FBA;b4153;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b4153;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b4153;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b4153;;for_c --> for_e;0.0;0.0
FRD7;b4153;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b4153;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b4153;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b4153;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b4153;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b4153;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b4153;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b4153;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b4153;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b4153;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b4153;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b4153;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b4153;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b4153;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b4153;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b4153;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b4153;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b4153;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b4153;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b4153;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b4153;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b4153;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b4153;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b4153;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b4153;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b4153;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b4153;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b4153;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b4153;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b4153;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b4153;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b4153;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b4153;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b4153;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b4153;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b4153;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b4153;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b4153;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b4153;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b4153;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b4153;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b4153;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b4153;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b4153;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b4153;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b4153;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b4153;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b4153;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b4153;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b4153;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b4153;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b4153;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b4151;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b4151;;acald_e <=> acald_c;0.0;0.0
ACKr;b4151;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b4151;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b4151;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b4151;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b4151;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b4151;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b4151;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b4151;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b4151;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b4151;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b4151;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b4151;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b4151;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b4151;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b4151;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b4151;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b4151;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b4151;;ac_e --> ;0.0;0.0
EX_acald_e;b4151;;acald_e --> ;0.0;0.0
EX_akg_e;b4151;;akg_e --> ;0.0;0.0
EX_co2_e;b4151;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b4151;;etoh_e --> ;0.0;0.0
EX_for_e;b4151;;for_e --> ;0.0;0.0
EX_fru_e;b4151;;fru_e --> ;0.0;0.0
EX_fum_e;b4151;;fum_e --> ;0.0;0.0
EX_glc__D_e;b4151;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b4151;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b4151;;glu__L_e --> ;0.0;0.0
EX_h_e;b4151;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b4151;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b4151;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b4151;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b4151;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b4151;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b4151;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b4151;;pyr_e --> ;0.0;0.0
EX_succ_e;b4151;;succ_e --> ;0.0;0.0
FBA;b4151;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b4151;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b4151;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b4151;;for_c --> for_e;0.0;0.0
FRD7;b4151;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b4151;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b4151;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b4151;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b4151;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b4151;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b4151;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b4151;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b4151;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b4151;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b4151;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b4151;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b4151;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b4151;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b4151;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b4151;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b4151;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b4151;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b4151;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b4151;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b4151;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b4151;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b4151;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b4151;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b4151;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b4151;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b4151;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b4151;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b4151;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b4151;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b4151;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b4151;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b4151;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b4151;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b4151;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b4151;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b4151;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b4151;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b4151;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b4151;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b4151;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b4151;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b4151;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b4151;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b4151;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b4151;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b4151;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b4151;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b4151;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b4151;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b4151;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b4151;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b1819;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b1819;;acald_e <=> acald_c;0.0;0.0
ACKr;b1819;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b1819;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b1819;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b1819;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b1819;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b1819;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b1819;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b1819;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b1819;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b1819;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b1819;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b1819;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b1819;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b1819;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b1819;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b1819;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b1819;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b1819;;ac_e --> ;0.0;0.0
EX_acald_e;b1819;;acald_e --> ;0.0;0.0
EX_akg_e;b1819;;akg_e --> ;0.0;0.0
EX_co2_e;b1819;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b1819;;etoh_e --> ;0.0;0.0
EX_for_e;b1819;;for_e --> ;0.0;0.0
EX_fru_e;b1819;;fru_e --> ;0.0;0.0
EX_fum_e;b1819;;fum_e --> ;0.0;0.0
EX_glc__D_e;b1819;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b1819;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b1819;;glu__L_e --> ;0.0;0.0
EX_h_e;b1819;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b1819;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b1819;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b1819;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b1819;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b1819;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b1819;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b1819;;pyr_e --> ;0.0;0.0
EX_succ_e;b1819;;succ_e --> ;0.0;0.0
FBA;b1819;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b1819;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b1819;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b1819;;for_c --> for_e;0.0;0.0
FRD7;b1819;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b1819;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b1819;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b1819;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b1819;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b1819;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b1819;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b1819;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b1819;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b1819;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b1819;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b1819;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b1819;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b1819;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b1819;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b1819;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b1819;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b1819;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b1819;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b1819;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b1819;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b1819;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b1819;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b1819;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b1819;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b1819;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b1819;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b1819;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b1819;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b1819;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b1819;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b1819;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b1819;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b1819;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b1819;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b1819;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b1819;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b1819;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b1819;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b1819;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b1819;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b1819;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b1819;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b1819;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b1819;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b1819;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b1819;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b1819;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b1819;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b1819;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b1819;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b1819;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b1817;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b1817;;acald_e <=> acald_c;0.0;0.0
ACKr;b1817;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b1817;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b1817;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b1817;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b1817;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b1817;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b1817;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b1817;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b1817;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b1817;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b1817;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b1817;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b1817;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b1817;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b1817;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b1817;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b1817;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b1817;;ac_e --> ;0.0;0.0
EX_acald_e;b1817;;acald_e --> ;0.0;0.0
EX_akg_e;b1817;;akg_e --> ;0.0;0.0
EX_co2_e;b1817;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b1817;;etoh_e --> ;0.0;0.0
EX_for_e;b1817;;for_e --> ;0.0;0.0
EX_fru_e;b1817;;fru_e --> ;0.0;0.0
EX_fum_e;b1817;;fum_e --> ;0.0;0.0
EX_glc__D_e;b1817;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b1817;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b1817;;glu__L_e --> ;0.0;0.0
EX_h_e;b1817;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b1817;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b1817;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b1817;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b1817;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b1817;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b1817;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b1817;;pyr_e --> ;0.0;0.0
EX_succ_e;b1817;;succ_e --> ;0.0;0.0
FBA;b1817;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b1817;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b1817;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b1817;;for_c --> for_e;0.0;0.0
FRD7;b1817;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b1817;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b1817;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b1817;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b1817;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b1817;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b1817;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b1817;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b1817;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b1817;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b1817;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b1817;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b1817;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b1817;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b1817;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b1817;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b1817;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b1817;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b1817;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b1817;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b1817;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b1817;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b1817;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b1817;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b1817;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b1817;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b1817;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b1817;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b1817;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b1817;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b1817;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b1817;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b1817;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b1817;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b1817;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b1817;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b1817;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b1817;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b1817;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b1817;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b1817;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b1817;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b1817;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b1817;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b1817;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b1817;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b1817;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b1817;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b1817;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b1817;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b1817;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b1817;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b2415;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b2415;;acald_e <=> acald_c;0.0;0.0
ACKr;b2415;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b2415;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;0.9588571428571432
ACONTb;b2415;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;0.9588571428571433
ACt2r;b2415;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b2415;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b2415;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.9588571428571432
AKGt2r;b2415;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b2415;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b2415;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b2415;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;6.4722857142857135
Biomass_Ecoli_core;b2415;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.0
CO2t;b2415;;co2_e <=> co2_c;-22.809833310205086;-2.8765714285714292
CS;b2415;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;0.9588571428571431
CYTBD;b2415;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;5.753142857142859
D_LACt2;b2415;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b2415;;2pg_c <=> h2o_c + pep_c;14.716139568742859;0.9588571428571427
ETOHt2r;b2415;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b2415;;ac_e --> ;0.0;0.0
EX_acald_e;b2415;;acald_e --> ;0.0;0.0
EX_akg_e;b2415;;akg_e --> ;0.0;0.0
EX_co2_e;b2415;;co2_e <=> ;22.809833310205086;2.8765714285714292
EX_etoh_e;b2415;;etoh_e --> ;0.0;0.0
EX_for_e;b2415;;for_e --> ;0.0;0.0
EX_fru_e;b2415;;fru_e --> ;0.0;0.0
EX_fum_e;b2415;;fum_e --> ;0.0;0.0
EX_glc__D_e;b2415;;glc__D_e <=> ;-10.0;-0.47942857142857065
EX_gln__L_e;b2415;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b2415;;glu__L_e --> ;0.0;0.0
EX_h_e;b2415;;h_e <=> ;17.530865429786523;4.9191014266707225e-15
EX_h2o_e;b2415;;h2o_e <=> ;29.175827135565836;2.8765714285714297
EX_lac__D_e;b2415;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b2415;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b2415;;nh4_e <=> ;-4.765319193197444;0.0
EX_o2_e;b2415;;o2_e <=> ;-21.799492655998886;-2.876571428571429
EX_pi_e;b2415;;pi_e <=> ;-3.214895047684769;-1.44603579811754e-16
EX_pyr_e;b2415;;pyr_e --> ;0.0;0.0
EX_succ_e;b2415;;succ_e --> ;0.0;0.0
FBA;b2415;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;0.47942857142857126
FBP;b2415;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b2415;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b2415;;for_c --> for_e;0.0;0.0
FRD7;b2415;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b2415;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b2415;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;0.9588571428571431
FUMt2_2;b2415;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b2415;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;0.0
GAPD;b2415;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;0.9588571428571426
GLCpts;b2415;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;0.4794285714285713
GLNS;b2415;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.0
GLNabc;b2415;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b2415;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;0.0
GLUN;b2415;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b2415;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b2415;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b2415;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;0.0
H2Ot;b2415;;h2o_e <=> h2o_c;-29.175827135565836;-2.8765714285714297
ICDHyr;b2415;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.9588571428571432
ICL;b2415;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b2415;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b2415;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b2415;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b2415;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;0.9588571428571432
ME1;b2415;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b2415;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b2415;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;4.794285714285715
NADTRHD;b2415;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.9588571428571433
NH4t;b2415;;nh4_e <=> nh4_c;4.765319193197444;0.0
O2t;b2415;;o2_e <=> o2_c;21.799492655998886;2.876571428571429
PDH;b2415;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;0.9588571428571431
PFK;b2415;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;0.4794285714285713
PFL;b2415;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b2415;;g6p_c <=> f6p_c;4.860861146496871;0.4794285714285713
PGK;b2415;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-0.9588571428571429
PGL;b2415;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;0.0
PGM;b2415;;2pg_c <=> 3pg_c;-14.716139568742859;-0.9588571428571427
PIt2r;b2415;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;1.44603579811754e-16
PPC;b2415;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;-2.1787822771044144e-16
PPCK;b2415;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b2415;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b2415;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b2415;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;0.4794285714285715
PYRt2;b2415;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b2415;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;0.0
RPI;b2415;;r5p_c <=> ru5p__D_c;-2.2815030940671064;0.0
SUCCt2_2;b2415;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b2415;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b2415;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;0.9588571428571433
SUCOAS;b2415;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-0.9588571428571433
TALA;b2415;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;0.0
THD2;b2415;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b2415;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;0.0
TKT2;b2415;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;0.0
TPI;b2415;;dhap_c <=> g3p_c;7.477381962160304;0.47942857142857126
ACALD;b1818;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b1818;;acald_e <=> acald_c;0.0;0.0
ACKr;b1818;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b1818;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350335
ACONTb;b1818;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350335
ACt2r;b1818;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b1818;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b1818;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482098
AKGt2r;b1818;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b1818;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b1818;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b1818;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.51400977451748
Biomass_Ecoli_core;b1818;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684306
CO2t;b1818;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b1818;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350334
CYTBD;b1818;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199754
D_LACt2;b1818;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b1818;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.71613956874283
ETOHt2r;b1818;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b1818;;ac_e --> ;0.0;0.0
EX_acald_e;b1818;;acald_e --> ;0.0;0.0
EX_akg_e;b1818;;akg_e --> ;0.0;0.0
EX_co2_e;b1818;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b1818;;etoh_e --> ;0.0;0.0
EX_for_e;b1818;;for_e --> ;0.0;0.0
EX_fru_e;b1818;;fru_e --> ;0.0;0.0
EX_fum_e;b1818;;fum_e --> ;0.0;0.0
EX_glc__D_e;b1818;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b1818;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b1818;;glu__L_e --> ;0.0;0.0
EX_h_e;b1818;;h_e <=> ;17.530865429786523;17.530865429786658
EX_h2o_e;b1818;;h2o_e <=> ;29.175827135565836;29.175827135565825
EX_lac__D_e;b1818;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b1818;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b1818;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b1818;;o2_e <=> ;-21.799492655998886;-21.799492655998765
EX_pi_e;b1818;;pi_e <=> ;-3.214895047684769;-3.2148950476847853
EX_pyr_e;b1818;;pyr_e --> ;0.0;0.0
EX_succ_e;b1818;;succ_e --> ;0.0;0.0
FBA;b1818;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160285
FBP;b1818;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b1818;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b1818;;for_c --> for_e;0.0;0.0
FRD7;b1818;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b1818;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b1818;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482097
FUMt2_2;b1818;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b1818;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574658
GAPD;b1818;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167604
GLCpts;b1818;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b1818;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182767
GLNabc;b1818;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b1818;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b1818;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b1818;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b1818;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b1818;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.959984944574656
H2Ot;b1818;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565825
ICDHyr;b1818;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350335
ICL;b1818;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b1818;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b1818;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b1818;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b1818;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482098
ME1;b1818;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b1818;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b1818;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b1818;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b1818;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197457
O2t;b1818;;o2_e <=> o2_c;21.799492655998886;21.799492655998765
PDH;b1818;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.282532599166618
PFK;b1818;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160285
PFL;b1818;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b1818;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496815
PGK;b1818;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.023526143167608
PGL;b1818;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574657
PGM;b1818;;2pg_c <=> 3pg_c;-14.716139568742859;-14.71613956874283
PIt2r;b1818;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.2148950476847853
PPC;b1818;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.504309470368731
PPCK;b1818;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b1818;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b1818;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b1818;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.758177444106787
PYRt2;b1818;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b1818;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.6784818505075307
RPI;b1818;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.281503094067126
SUCCt2_2;b1818;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b1818;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b1818;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482098
SUCOAS;b1818;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482098
TALA;b1818;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615665
THD2;b1818;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b1818;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.496983757261566
TKT2;b1818;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245963
TPI;b1818;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160285
ACALD;b2416;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b2416;;acald_e <=> acald_c;0.0;0.0
ACKr;b2416;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b2416;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;0.9588571428571432
ACONTb;b2416;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;0.9588571428571433
ACt2r;b2416;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b2416;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b2416;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.9588571428571432
AKGt2r;b2416;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b2416;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b2416;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b2416;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;6.4722857142857135
Biomass_Ecoli_core;b2416;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.0
CO2t;b2416;;co2_e <=> co2_c;-22.809833310205086;-2.8765714285714292
CS;b2416;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;0.9588571428571431
CYTBD;b2416;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;5.753142857142859
D_LACt2;b2416;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b2416;;2pg_c <=> h2o_c + pep_c;14.716139568742859;0.9588571428571427
ETOHt2r;b2416;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b2416;;ac_e --> ;0.0;0.0
EX_acald_e;b2416;;acald_e --> ;0.0;0.0
EX_akg_e;b2416;;akg_e --> ;0.0;0.0
EX_co2_e;b2416;;co2_e <=> ;22.809833310205086;2.8765714285714292
EX_etoh_e;b2416;;etoh_e --> ;0.0;0.0
EX_for_e;b2416;;for_e --> ;0.0;0.0
EX_fru_e;b2416;;fru_e --> ;0.0;0.0
EX_fum_e;b2416;;fum_e --> ;0.0;0.0
EX_glc__D_e;b2416;;glc__D_e <=> ;-10.0;-0.47942857142857065
EX_gln__L_e;b2416;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b2416;;glu__L_e --> ;0.0;0.0
EX_h_e;b2416;;h_e <=> ;17.530865429786523;4.9191014266707225e-15
EX_h2o_e;b2416;;h2o_e <=> ;29.175827135565836;2.8765714285714297
EX_lac__D_e;b2416;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b2416;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b2416;;nh4_e <=> ;-4.765319193197444;0.0
EX_o2_e;b2416;;o2_e <=> ;-21.799492655998886;-2.876571428571429
EX_pi_e;b2416;;pi_e <=> ;-3.214895047684769;-1.44603579811754e-16
EX_pyr_e;b2416;;pyr_e --> ;0.0;0.0
EX_succ_e;b2416;;succ_e --> ;0.0;0.0
FBA;b2416;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;0.47942857142857126
FBP;b2416;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b2416;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b2416;;for_c --> for_e;0.0;0.0
FRD7;b2416;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b2416;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b2416;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;0.9588571428571431
FUMt2_2;b2416;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b2416;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;0.0
GAPD;b2416;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;0.9588571428571426
GLCpts;b2416;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;0.4794285714285713
GLNS;b2416;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.0
GLNabc;b2416;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b2416;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;0.0
GLUN;b2416;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b2416;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b2416;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b2416;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;0.0
H2Ot;b2416;;h2o_e <=> h2o_c;-29.175827135565836;-2.8765714285714297
ICDHyr;b2416;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.9588571428571432
ICL;b2416;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b2416;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b2416;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b2416;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b2416;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;0.9588571428571432
ME1;b2416;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b2416;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b2416;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;4.794285714285715
NADTRHD;b2416;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.9588571428571433
NH4t;b2416;;nh4_e <=> nh4_c;4.765319193197444;0.0
O2t;b2416;;o2_e <=> o2_c;21.799492655998886;2.876571428571429
PDH;b2416;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;0.9588571428571431
PFK;b2416;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;0.4794285714285713
PFL;b2416;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b2416;;g6p_c <=> f6p_c;4.860861146496871;0.4794285714285713
PGK;b2416;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-0.9588571428571429
PGL;b2416;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;0.0
PGM;b2416;;2pg_c <=> 3pg_c;-14.716139568742859;-0.9588571428571427
PIt2r;b2416;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;1.44603579811754e-16
PPC;b2416;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;-2.1787822771044144e-16
PPCK;b2416;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b2416;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b2416;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b2416;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;0.4794285714285715
PYRt2;b2416;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b2416;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;0.0
RPI;b2416;;r5p_c <=> ru5p__D_c;-2.2815030940671064;0.0
SUCCt2_2;b2416;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b2416;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b2416;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;0.9588571428571433
SUCOAS;b2416;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-0.9588571428571433
TALA;b2416;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;0.0
THD2;b2416;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b2416;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;0.0
TKT2;b2416;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;0.0
TPI;b2416;;dhap_c <=> g3p_c;7.477381962160304;0.47942857142857126
ACALD;b1611;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b1611;;acald_e <=> acald_c;0.0;0.0
ACKr;b1611;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b1611;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350335
ACONTb;b1611;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350335
ACt2r;b1611;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b1611;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b1611;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482098
AKGt2r;b1611;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b1611;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b1611;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b1611;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.51400977451748
Biomass_Ecoli_core;b1611;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684306
CO2t;b1611;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b1611;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350334
CYTBD;b1611;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199754
D_LACt2;b1611;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b1611;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.71613956874283
ETOHt2r;b1611;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b1611;;ac_e --> ;0.0;0.0
EX_acald_e;b1611;;acald_e --> ;0.0;0.0
EX_akg_e;b1611;;akg_e --> ;0.0;0.0
EX_co2_e;b1611;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b1611;;etoh_e --> ;0.0;0.0
EX_for_e;b1611;;for_e --> ;0.0;0.0
EX_fru_e;b1611;;fru_e --> ;0.0;0.0
EX_fum_e;b1611;;fum_e --> ;0.0;0.0
EX_glc__D_e;b1611;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b1611;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b1611;;glu__L_e --> ;0.0;0.0
EX_h_e;b1611;;h_e <=> ;17.530865429786523;17.530865429786658
EX_h2o_e;b1611;;h2o_e <=> ;29.175827135565836;29.175827135565825
EX_lac__D_e;b1611;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b1611;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b1611;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b1611;;o2_e <=> ;-21.799492655998886;-21.799492655998765
EX_pi_e;b1611;;pi_e <=> ;-3.214895047684769;-3.2148950476847853
EX_pyr_e;b1611;;pyr_e --> ;0.0;0.0
EX_succ_e;b1611;;succ_e --> ;0.0;0.0
FBA;b1611;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160285
FBP;b1611;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b1611;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b1611;;for_c --> for_e;0.0;0.0
FRD7;b1611;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b1611;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b1611;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482097
FUMt2_2;b1611;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b1611;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574658
GAPD;b1611;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167604
GLCpts;b1611;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b1611;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182767
GLNabc;b1611;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b1611;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b1611;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b1611;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b1611;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b1611;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.959984944574656
H2Ot;b1611;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565825
ICDHyr;b1611;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350335
ICL;b1611;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b1611;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b1611;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b1611;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b1611;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482098
ME1;b1611;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b1611;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b1611;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b1611;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b1611;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197457
O2t;b1611;;o2_e <=> o2_c;21.799492655998886;21.799492655998765
PDH;b1611;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.282532599166618
PFK;b1611;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160285
PFL;b1611;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b1611;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496815
PGK;b1611;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.023526143167608
PGL;b1611;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574657
PGM;b1611;;2pg_c <=> 3pg_c;-14.716139568742859;-14.71613956874283
PIt2r;b1611;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.2148950476847853
PPC;b1611;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.504309470368731
PPCK;b1611;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b1611;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b1611;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b1611;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.758177444106787
PYRt2;b1611;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b1611;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.6784818505075307
RPI;b1611;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.281503094067126
SUCCt2_2;b1611;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b1611;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b1611;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482098
SUCOAS;b1611;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482098
TALA;b1611;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615665
THD2;b1611;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b1611;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.496983757261566
TKT2;b1611;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245963
TPI;b1611;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160285
ACALD;b4122;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b4122;;acald_e <=> acald_c;0.0;0.0
ACKr;b4122;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b4122;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b4122;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b4122;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b4122;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b4122;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b4122;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b4122;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b4122;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b4122;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b4122;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b4122;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b4122;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b4122;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b4122;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b4122;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b4122;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b4122;;ac_e --> ;0.0;0.0
EX_acald_e;b4122;;acald_e --> ;0.0;0.0
EX_akg_e;b4122;;akg_e --> ;0.0;0.0
EX_co2_e;b4122;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b4122;;etoh_e --> ;0.0;0.0
EX_for_e;b4122;;for_e --> ;0.0;0.0
EX_fru_e;b4122;;fru_e --> ;0.0;0.0
EX_fum_e;b4122;;fum_e --> ;0.0;0.0
EX_glc__D_e;b4122;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b4122;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b4122;;glu__L_e --> ;0.0;0.0
EX_h_e;b4122;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b4122;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b4122;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b4122;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b4122;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b4122;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b4122;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b4122;;pyr_e --> ;0.0;0.0
EX_succ_e;b4122;;succ_e --> ;0.0;0.0
FBA;b4122;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b4122;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b4122;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b4122;;for_c --> for_e;0.0;0.0
FRD7;b4122;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b4122;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b4122;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b4122;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b4122;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b4122;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b4122;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b4122;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b4122;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b4122;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b4122;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b4122;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b4122;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b4122;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b4122;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b4122;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b4122;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b4122;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b4122;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b4122;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b4122;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b4122;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b4122;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b4122;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b4122;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b4122;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b4122;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b4122;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b4122;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b4122;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b4122;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b4122;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b4122;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b4122;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b4122;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b4122;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b4122;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b4122;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b4122;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b4122;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b4122;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b4122;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b4122;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b4122;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b4122;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b4122;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b4122;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b4122;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b4122;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b4122;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b4122;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b4122;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b1612;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b1612;;acald_e <=> acald_c;0.0;0.0
ACKr;b1612;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b1612;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b1612;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b1612;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b1612;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b1612;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b1612;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b1612;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b1612;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b1612;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b1612;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b1612;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b1612;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b1612;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b1612;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b1612;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b1612;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b1612;;ac_e --> ;0.0;0.0
EX_acald_e;b1612;;acald_e --> ;0.0;0.0
EX_akg_e;b1612;;akg_e --> ;0.0;0.0
EX_co2_e;b1612;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b1612;;etoh_e --> ;0.0;0.0
EX_for_e;b1612;;for_e --> ;0.0;0.0
EX_fru_e;b1612;;fru_e --> ;0.0;0.0
EX_fum_e;b1612;;fum_e --> ;0.0;0.0
EX_glc__D_e;b1612;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b1612;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b1612;;glu__L_e --> ;0.0;0.0
EX_h_e;b1612;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b1612;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b1612;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b1612;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b1612;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b1612;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b1612;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b1612;;pyr_e --> ;0.0;0.0
EX_succ_e;b1612;;succ_e --> ;0.0;0.0
FBA;b1612;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b1612;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b1612;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b1612;;for_c --> for_e;0.0;0.0
FRD7;b1612;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b1612;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b1612;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b1612;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b1612;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b1612;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b1612;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b1612;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b1612;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b1612;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b1612;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b1612;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b1612;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b1612;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b1612;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b1612;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b1612;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b1612;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b1612;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b1612;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b1612;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b1612;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b1612;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b1612;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b1612;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b1612;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b1612;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b1612;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b1612;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b1612;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b1612;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b1612;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b1612;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b1612;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b1612;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b1612;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b1612;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b1612;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b1612;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b1612;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b1612;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b1612;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b1612;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b1612;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b1612;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b1612;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b1612;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b1612;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b1612;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b1612;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b1612;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b1612;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b3528;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b3528;;acald_e <=> acald_c;0.0;0.0
ACKr;b3528;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b3528;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b3528;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b3528;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b3528;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b3528;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b3528;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b3528;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b3528;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b3528;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b3528;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b3528;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b3528;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b3528;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b3528;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b3528;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b3528;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b3528;;ac_e --> ;0.0;0.0
EX_acald_e;b3528;;acald_e --> ;0.0;0.0
EX_akg_e;b3528;;akg_e --> ;0.0;0.0
EX_co2_e;b3528;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b3528;;etoh_e --> ;0.0;0.0
EX_for_e;b3528;;for_e --> ;0.0;0.0
EX_fru_e;b3528;;fru_e --> ;0.0;0.0
EX_fum_e;b3528;;fum_e --> ;0.0;0.0
EX_glc__D_e;b3528;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b3528;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b3528;;glu__L_e --> ;0.0;0.0
EX_h_e;b3528;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b3528;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b3528;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b3528;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b3528;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b3528;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b3528;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b3528;;pyr_e --> ;0.0;0.0
EX_succ_e;b3528;;succ_e --> ;0.0;0.0
FBA;b3528;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b3528;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b3528;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b3528;;for_c --> for_e;0.0;0.0
FRD7;b3528;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b3528;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b3528;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b3528;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b3528;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b3528;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b3528;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b3528;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b3528;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b3528;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b3528;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b3528;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b3528;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b3528;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b3528;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b3528;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b3528;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b3528;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b3528;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b3528;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b3528;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b3528;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b3528;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b3528;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b3528;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b3528;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b3528;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b3528;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b3528;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b3528;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b3528;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b3528;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b3528;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b3528;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b3528;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b3528;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b3528;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b3528;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b3528;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b3528;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b3528;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b3528;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b3528;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b3528;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b3528;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b3528;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b3528;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b3528;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b3528;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b3528;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b3528;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b3528;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b1852;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b1852;;acald_e <=> acald_c;0.0;0.0
ACKr;b1852;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b1852;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;7.803301595127319
ACONTb;b1852;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;7.80330159512732
ACt2r;b1852;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b1852;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b1852;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;6.871333415503454
AKGt2r;b1852;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b1852;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b1852;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b1852;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;41.35354605121254
Biomass_Ecoli_core;b1852;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.863813309504001
CO2t;b1852;;co2_e <=> co2_c;-22.809833310205086;-23.239992707402525
CS;b1852;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;7.803301595127319
CYTBD;b1852;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;44.48267628056989
D_LACt2;b1852;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b1852;;2pg_c <=> h2o_c + pep_c;14.716139568742859;16.411460368327536
ETOHt2r;b1852;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b1852;;ac_e --> ;0.0;0.0
EX_acald_e;b1852;;acald_e --> ;0.0;0.0
EX_akg_e;b1852;;akg_e --> ;0.0;0.0
EX_co2_e;b1852;;co2_e <=> ;22.809833310205086;23.239992707402525
EX_etoh_e;b1852;;etoh_e --> ;0.0;0.0
EX_for_e;b1852;;for_e --> ;0.0;0.0
EX_fru_e;b1852;;fru_e --> ;0.0;0.0
EX_fum_e;b1852;;fum_e --> ;0.0;0.0
EX_glc__D_e;b1852;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b1852;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b1852;;glu__L_e --> ;0.0;0.0
EX_h_e;b1852;;h_e <=> ;17.530865429786523;17.328094988650292
EX_h2o_e;b1852;;h2o_e <=> ;29.175827135565836;29.53235437915348
EX_lac__D_e;b1852;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b1852;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b1852;;nh4_e <=> ;-4.765319193197444;-4.7102012140634155
EX_o2_e;b1852;;o2_e <=> ;-21.799492655998886;-22.24133814028494
EX_pi_e;b1852;;pi_e <=> ;-3.214895047684769;-3.1777100216723975
EX_pyr_e;b1852;;pyr_e --> ;0.0;0.0
EX_succ_e;b1852;;succ_e --> ;0.0;0.0
FBA;b1852;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;9.140764901036372
FBP;b1852;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b1852;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b1852;;for_c --> for_e;0.0;0.0
FRD7;b1852;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b1852;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b1852;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;6.871333415503454
FUMt2_2;b1852;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b1852;;g6p_c + nadp_c --> 6pgl_c + h_c + nadph_c;4.959984944574603;0.0
GAPD;b1852;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;17.70372507934552
GLCpts;b1852;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b1852;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22087706324017306
GLNabc;b1852;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b1852;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.489324150823243
GLUN;b1852;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b1852;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b1852;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b1852;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;0.0
H2Ot;b1852;;h2o_e <=> h2o_c;-29.175827135565836;-29.53235437915348
ICDHyr;b1852;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;7.803301595127319
ICL;b1852;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b1852;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b1852;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b1852;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b1852;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;6.871333415503454
ME1;b1852;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b1852;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b1852;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;37.61134286506643
NADTRHD;b1852;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b1852;;nh4_e <=> nh4_c;4.765319193197444;4.7102012140634155
O2t;b1852;;o2_e <=> o2_c;21.799492655998886;22.24133814028494
PDH;b1852;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;11.040701116486412
PFK;b1852;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;9.140764901036372
PFL;b1852;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b1852;;g6p_c <=> f6p_c;4.860861146496871;9.82291827155168
PGK;b1852;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-17.70372507934552
PGL;b1852;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;0.0
PGM;b1852;;2pg_c <=> 3pg_c;-14.716139568742859;-16.411460368327536
PIt2r;b1852;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.1777100216723975
PPC;b1852;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.4753434197146587
PPCK;b1852;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b1852;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b1852;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b1852;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;3.4877114596493457
PYRt2;b1852;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b1852;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;-0.6209090068714763
RPI;b1852;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-0.6209090068714764
SUCCt2_2;b1852;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b1852;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b1852;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;6.871333415503454
SUCOAS;b1852;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-6.871333415503454
TALA;b1852;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;-0.15453620107026592
THD2;b1852;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;7.9396959705831085
TKT1;b1852;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;-0.1545362010702659
TKT2;b1852;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;-0.4663728058012104
TPI;b1852;;dhap_c <=> g3p_c;7.477381962160304;9.140764901036372
ACALD;b1779;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b1779;;acald_e <=> acald_c;0.0;0.0
ACKr;b1779;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b1779;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;-1.7390192571944755e-16
ACONTb;b1779;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;-1.7390192571944758e-16
ACt2r;b1779;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b1779;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.6453846153846129
AKGDH;b1779;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0
AKGt2r;b1779;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b1779;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b1779;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b1779;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;9.68076923076922
Biomass_Ecoli_core;b1779;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;4.5720105671090073e-17
CO2t;b1779;;co2_e <=> co2_c;-22.809833310205086;-3.8723076923076882
CS;b1779;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;-1.7390192571944753e-16
CYTBD;b1779;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;7.744615384615376
D_LACt2;b1779;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b1779;;2pg_c <=> h2o_c + pep_c;14.716139568742859;-6.839727808395076e-17
ETOHt2r;b1779;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b1779;;ac_e --> ;0.0;0.0
EX_acald_e;b1779;;acald_e --> ;0.0;0.0
EX_akg_e;b1779;;akg_e --> ;0.0;0.0
EX_co2_e;b1779;;co2_e <=> ;22.809833310205086;3.8723076923076882
EX_etoh_e;b1779;;etoh_e --> ;0.0;0.0
EX_for_e;b1779;;for_e --> ;0.0;0.0
EX_fru_e;b1779;;fru_e --> ;0.0;0.0
EX_fum_e;b1779;;fum_e --> ;0.0;0.0
EX_glc__D_e;b1779;;glc__D_e <=> ;-10.0;-0.6453846153846143
EX_gln__L_e;b1779;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b1779;;glu__L_e --> ;0.0;0.0
EX_h_e;b1779;;h_e <=> ;17.530865429786523;0.0
EX_h2o_e;b1779;;h2o_e <=> ;29.175827135565836;3.872307692307676
EX_lac__D_e;b1779;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b1779;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b1779;;nh4_e <=> ;-4.765319193197444;-3.0613068465124946e-16
EX_o2_e;b1779;;o2_e <=> ;-21.799492655998886;-3.872307692307687
EX_pi_e;b1779;;pi_e <=> ;-3.214895047684769;8.637187419524205e-15
EX_pyr_e;b1779;;pyr_e --> ;0.0;0.0
EX_succ_e;b1779;;succ_e --> ;0.0;0.0
FBA;b1779;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;-0.6453846153846177
FBP;b1779;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.6453846153846179
FORt2;b1779;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b1779;;for_c --> for_e;0.0;0.0
FRD7;b1779;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b1779;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b1779;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;2.1965441388078088e-16
FUMt2_2;b1779;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b1779;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;3.8723076923076887
GAPD;b1779;;g3p_c + nad_c + pi_c --> 13dpg_c + h_c + nadh_c;16.023526143167626;0.0
GLCpts;b1779;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;0.645384615384614
GLNS;b1779;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;1.169063102009773e-17
GLNabc;b1779;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b1779;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-2.376119611832222e-16
GLUN;b1779;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b1779;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b1779;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b1779;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;3.8723076923076887
H2Ot;b1779;;h2o_e <=> h2o_c;-29.175827135565836;-3.872307692307676
ICDHyr;b1779;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;7.47099446372644e-16
ICL;b1779;;icit_c --> glx_c + succ_c;0.0;-9.210013720920916e-16
LDH_D;b1779;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b1779;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;-9.210013720920916e-16
MALt2_2;b1779;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b1779;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;-7.013469582113107e-16
ME1;b1779;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b1779;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b1779;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;7.744615384615374
NADTRHD;b1779;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;7.74461538461538
NH4t;b1779;;nh4_e <=> nh4_c;4.765319193197444;2.493025922033199e-16
O2t;b1779;;o2_e <=> o2_c;21.799492655998886;3.872307692307687
PDH;b1779;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;0.0
PFK;b1779;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;0.0
PFL;b1779;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b1779;;g6p_c <=> f6p_c;4.860861146496871;-3.2269230769230766
PGK;b1779;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;0.0
PGL;b1779;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;3.872307692307689
PGM;b1779;;2pg_c <=> 3pg_c;-14.716139568742859;6.839727808395074e-17
PIt2r;b1779;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;-8.637187419524205e-15
PPC;b1779;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;0.0
PPCK;b1779;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;-6.091331452944002e-16
PPS;b1779;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.6453846153846129
PTAr;b1779;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b1779;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;0.0
PYRt2;b1779;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b1779;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.581538461538459
RPI;b1779;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-1.2907692307692298
SUCCt2_2;b1779;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b1779;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b1779;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;2.196544138807808e-16
SUCOAS;b1779;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-1.1406557859728724e-15
TALA;b1779;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.2907692307692296
THD2;b1779;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b1779;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.2907692307692296
TKT2;b1779;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.2907692307692296
TPI;b1779;;dhap_c <=> g3p_c;7.477381962160304;-0.6453846153846177
ACALD;b1621;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b1621;;acald_e <=> acald_c;0.0;0.0
ACKr;b1621;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b1621;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350344
ACONTb;b1621;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350345
ACt2r;b1621;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b1621;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b1621;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482106
AKGt2r;b1621;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b1621;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b1621;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b1621;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517454
Biomass_Ecoli_core;b1621;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684306
CO2t;b1621;;co2_e <=> co2_c;-22.809833310205086;-22.809833310205
CS;b1621;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350344
CYTBD;b1621;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.598985311997595
D_LACt2;b1621;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b1621;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742845
ETOHt2r;b1621;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b1621;;ac_e --> ;0.0;0.0
EX_acald_e;b1621;;acald_e --> ;0.0;0.0
EX_akg_e;b1621;;akg_e --> ;0.0;0.0
EX_co2_e;b1621;;co2_e <=> ;22.809833310205086;22.809833310205
EX_etoh_e;b1621;;etoh_e --> ;0.0;0.0
EX_for_e;b1621;;for_e --> ;0.0;0.0
EX_fru_e;b1621;;fru_e --> ;0.0;0.0
EX_fum_e;b1621;;fum_e --> ;0.0;0.0
EX_glc__D_e;b1621;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b1621;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b1621;;glu__L_e --> ;0.0;0.0
EX_h_e;b1621;;h_e <=> ;17.530865429786523;17.530865429787013
EX_h2o_e;b1621;;h2o_e <=> ;29.175827135565836;29.175827135565843
EX_lac__D_e;b1621;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b1621;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b1621;;nh4_e <=> ;-4.765319193197444;-4.76531919319746
EX_o2_e;b1621;;o2_e <=> ;-21.799492655998886;-21.799492655998794
EX_pi_e;b1621;;pi_e <=> ;-3.214895047684769;-3.2148950476847915
EX_pyr_e;b1621;;pyr_e --> ;0.0;0.0
EX_succ_e;b1621;;succ_e --> ;0.0;0.0
FBA;b1621;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160297
FBP;b1621;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b1621;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b1621;;for_c --> for_e;0.0;0.0
FRD7;b1621;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b1621;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b1621;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.0643756614821065
FUMt2_2;b1621;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b1621;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574655
GAPD;b1621;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.02352614316762
GLCpts;b1621;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000009
GLNS;b1621;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182767
GLNabc;b1621;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b1621;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.541857463865631
GLUN;b1621;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b1621;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b1621;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b1621;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.959984944574654
H2Ot;b1621;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565843
ICDHyr;b1621;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350345
ICL;b1621;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b1621;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b1621;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b1621;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b1621;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482108
ME1;b1621;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b1621;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b1621;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515485
NADTRHD;b1621;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b1621;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197457
O2t;b1621;;o2_e <=> o2_c;21.799492655998886;21.799492655998794
PDH;b1621;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.282532599166629
PFK;b1621;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160302
PFL;b1621;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b1621;;g6p_c <=> f6p_c;4.860861146496871;4.8608611464968465
PGK;b1621;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316762
PGL;b1621;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574655
PGM;b1621;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742845
PIt2r;b1621;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.2148950476847915
PPC;b1621;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.504309470368733
PPCK;b1621;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b1621;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b1621;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b1621;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.75817744410679
PYRt2;b1621;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b1621;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.6784818505075276
RPI;b1621;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.281503094067127
SUCCt2_2;b1621;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b1621;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b1621;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482106
SUCOAS;b1621;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482106
TALA;b1621;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615659
THD2;b1621;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b1621;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615656
TKT2;b1621;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.1814980932459624
TPI;b1621;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160297
ACALD;b1101;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b1101;;acald_e <=> acald_c;0.0;0.0
ACKr;b1101;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b1101;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b1101;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b1101;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b1101;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b1101;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b1101;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b1101;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b1101;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b1101;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b1101;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b1101;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b1101;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b1101;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b1101;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b1101;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b1101;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b1101;;ac_e --> ;0.0;0.0
EX_acald_e;b1101;;acald_e --> ;0.0;0.0
EX_akg_e;b1101;;akg_e --> ;0.0;0.0
EX_co2_e;b1101;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b1101;;etoh_e --> ;0.0;0.0
EX_for_e;b1101;;for_e --> ;0.0;0.0
EX_fru_e;b1101;;fru_e --> ;0.0;0.0
EX_fum_e;b1101;;fum_e --> ;0.0;0.0
EX_glc__D_e;b1101;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b1101;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b1101;;glu__L_e --> ;0.0;0.0
EX_h_e;b1101;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b1101;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b1101;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b1101;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b1101;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b1101;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b1101;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b1101;;pyr_e --> ;0.0;0.0
EX_succ_e;b1101;;succ_e --> ;0.0;0.0
FBA;b1101;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b1101;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b1101;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b1101;;for_c --> for_e;0.0;0.0
FRD7;b1101;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b1101;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b1101;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b1101;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b1101;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b1101;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b1101;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b1101;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b1101;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b1101;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b1101;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b1101;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b1101;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b1101;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b1101;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b1101;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b1101;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b1101;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b1101;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b1101;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b1101;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b1101;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b1101;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b1101;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b1101;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b1101;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b1101;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b1101;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b1101;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b1101;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b1101;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b1101;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b1101;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b1101;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b1101;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b1101;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b1101;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b1101;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b1101;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b1101;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b1101;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b1101;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b1101;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b1101;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b1101;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b1101;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b1101;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b1101;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b1101;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b1101;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b1101;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b1101;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b2417;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b2417;;acald_e <=> acald_c;0.0;0.0
ACKr;b2417;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b2417;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b2417;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b2417;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b2417;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b2417;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b2417;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b2417;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b2417;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b2417;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b2417;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b2417;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b2417;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b2417;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b2417;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b2417;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b2417;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b2417;;ac_e --> ;0.0;0.0
EX_acald_e;b2417;;acald_e --> ;0.0;0.0
EX_akg_e;b2417;;akg_e --> ;0.0;0.0
EX_co2_e;b2417;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b2417;;etoh_e --> ;0.0;0.0
EX_for_e;b2417;;for_e --> ;0.0;0.0
EX_fru_e;b2417;;fru_e --> ;0.0;0.0
EX_fum_e;b2417;;fum_e --> ;0.0;0.0
EX_glc__D_e;b2417;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b2417;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b2417;;glu__L_e --> ;0.0;0.0
EX_h_e;b2417;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b2417;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b2417;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b2417;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b2417;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b2417;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b2417;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b2417;;pyr_e --> ;0.0;0.0
EX_succ_e;b2417;;succ_e --> ;0.0;0.0
FBA;b2417;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b2417;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b2417;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b2417;;for_c --> for_e;0.0;0.0
FRD7;b2417;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b2417;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b2417;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b2417;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b2417;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b2417;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b2417;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b2417;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b2417;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b2417;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b2417;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b2417;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b2417;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b2417;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b2417;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b2417;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b2417;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b2417;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b2417;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b2417;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b2417;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b2417;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b2417;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b2417;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b2417;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b2417;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b2417;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b2417;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b2417;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b2417;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b2417;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b2417;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b2417;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b2417;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b2417;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b2417;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b2417;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b2417;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b2417;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b2417;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b2417;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b2417;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b2417;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b2417;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b2417;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b2417;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b2417;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b2417;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b2417;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b2417;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b2417;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b2417;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b3870;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b3870;;acald_e <=> acald_c;0.0;0.0
ACKr;b3870;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b3870;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b3870;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b3870;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b3870;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b3870;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b3870;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b3870;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b3870;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b3870;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b3870;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b3870;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b3870;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b3870;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b3870;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b3870;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b3870;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b3870;;ac_e --> ;0.0;0.0
EX_acald_e;b3870;;acald_e --> ;0.0;0.0
EX_akg_e;b3870;;akg_e --> ;0.0;0.0
EX_co2_e;b3870;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b3870;;etoh_e --> ;0.0;0.0
EX_for_e;b3870;;for_e --> ;0.0;0.0
EX_fru_e;b3870;;fru_e --> ;0.0;0.0
EX_fum_e;b3870;;fum_e --> ;0.0;0.0
EX_glc__D_e;b3870;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b3870;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b3870;;glu__L_e --> ;0.0;0.0
EX_h_e;b3870;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b3870;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b3870;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b3870;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b3870;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b3870;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b3870;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b3870;;pyr_e --> ;0.0;0.0
EX_succ_e;b3870;;succ_e --> ;0.0;0.0
FBA;b3870;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b3870;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b3870;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b3870;;for_c --> for_e;0.0;0.0
FRD7;b3870;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b3870;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b3870;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b3870;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b3870;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b3870;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b3870;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b3870;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b3870;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b3870;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b3870;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b3870;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b3870;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b3870;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b3870;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b3870;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b3870;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b3870;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b3870;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b3870;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b3870;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b3870;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b3870;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b3870;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b3870;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b3870;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b3870;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b3870;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b3870;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b3870;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b3870;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b3870;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b3870;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b3870;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b3870;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b3870;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b3870;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b3870;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b3870;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b3870;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b3870;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b3870;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b3870;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b3870;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b3870;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b3870;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b3870;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b3870;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b3870;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b3870;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b3870;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b3870;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b1297;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b1297;;acald_e <=> acald_c;0.0;0.0
ACKr;b1297;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b1297;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b1297;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b1297;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b1297;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b1297;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b1297;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b1297;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b1297;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b1297;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b1297;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b1297;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b1297;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b1297;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b1297;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b1297;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b1297;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b1297;;ac_e --> ;0.0;0.0
EX_acald_e;b1297;;acald_e --> ;0.0;0.0
EX_akg_e;b1297;;akg_e --> ;0.0;0.0
EX_co2_e;b1297;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b1297;;etoh_e --> ;0.0;0.0
EX_for_e;b1297;;for_e --> ;0.0;0.0
EX_fru_e;b1297;;fru_e --> ;0.0;0.0
EX_fum_e;b1297;;fum_e --> ;0.0;0.0
EX_glc__D_e;b1297;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b1297;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b1297;;glu__L_e --> ;0.0;0.0
EX_h_e;b1297;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b1297;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b1297;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b1297;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b1297;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b1297;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b1297;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b1297;;pyr_e --> ;0.0;0.0
EX_succ_e;b1297;;succ_e --> ;0.0;0.0
FBA;b1297;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b1297;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b1297;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b1297;;for_c --> for_e;0.0;0.0
FRD7;b1297;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b1297;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b1297;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b1297;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b1297;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b1297;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b1297;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b1297;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b1297;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b1297;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b1297;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b1297;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b1297;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b1297;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b1297;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b1297;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b1297;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b1297;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b1297;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b1297;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b1297;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b1297;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b1297;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b1297;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b1297;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b1297;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b1297;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b1297;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b1297;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b1297;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b1297;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b1297;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b1297;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b1297;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b1297;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b1297;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b1297;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b1297;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b1297;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b1297;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b1297;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b1297;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b1297;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b1297;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b1297;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b1297;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b1297;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b1297;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b1297;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b1297;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b1297;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b1297;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b0809;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b0809;;acald_e <=> acald_c;0.0;0.0
ACKr;b0809;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b0809;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b0809;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b0809;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b0809;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b0809;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b0809;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b0809;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b0809;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b0809;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b0809;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b0809;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b0809;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b0809;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b0809;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b0809;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b0809;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b0809;;ac_e --> ;0.0;0.0
EX_acald_e;b0809;;acald_e --> ;0.0;0.0
EX_akg_e;b0809;;akg_e --> ;0.0;0.0
EX_co2_e;b0809;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b0809;;etoh_e --> ;0.0;0.0
EX_for_e;b0809;;for_e --> ;0.0;0.0
EX_fru_e;b0809;;fru_e --> ;0.0;0.0
EX_fum_e;b0809;;fum_e --> ;0.0;0.0
EX_glc__D_e;b0809;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b0809;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b0809;;glu__L_e --> ;0.0;0.0
EX_h_e;b0809;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b0809;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b0809;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b0809;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b0809;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b0809;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b0809;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b0809;;pyr_e --> ;0.0;0.0
EX_succ_e;b0809;;succ_e --> ;0.0;0.0
FBA;b0809;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b0809;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b0809;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b0809;;for_c --> for_e;0.0;0.0
FRD7;b0809;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b0809;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b0809;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b0809;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b0809;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b0809;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b0809;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b0809;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b0809;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b0809;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b0809;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b0809;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b0809;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b0809;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b0809;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b0809;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b0809;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b0809;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b0809;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b0809;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b0809;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b0809;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b0809;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b0809;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b0809;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b0809;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b0809;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b0809;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b0809;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b0809;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b0809;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b0809;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b0809;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b0809;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b0809;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b0809;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b0809;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b0809;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b0809;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b0809;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b0809;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b0809;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b0809;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b0809;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b0809;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b0809;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b0809;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b0809;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b0809;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b0809;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b0809;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b0809;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b0810;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b0810;;acald_e <=> acald_c;0.0;0.0
ACKr;b0810;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b0810;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b0810;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b0810;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b0810;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b0810;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b0810;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b0810;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b0810;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b0810;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b0810;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b0810;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b0810;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b0810;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b0810;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b0810;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b0810;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b0810;;ac_e --> ;0.0;0.0
EX_acald_e;b0810;;acald_e --> ;0.0;0.0
EX_akg_e;b0810;;akg_e --> ;0.0;0.0
EX_co2_e;b0810;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b0810;;etoh_e --> ;0.0;0.0
EX_for_e;b0810;;for_e --> ;0.0;0.0
EX_fru_e;b0810;;fru_e --> ;0.0;0.0
EX_fum_e;b0810;;fum_e --> ;0.0;0.0
EX_glc__D_e;b0810;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b0810;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b0810;;glu__L_e --> ;0.0;0.0
EX_h_e;b0810;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b0810;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b0810;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b0810;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b0810;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b0810;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b0810;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b0810;;pyr_e --> ;0.0;0.0
EX_succ_e;b0810;;succ_e --> ;0.0;0.0
FBA;b0810;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b0810;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b0810;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b0810;;for_c --> for_e;0.0;0.0
FRD7;b0810;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b0810;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b0810;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b0810;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b0810;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b0810;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b0810;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b0810;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b0810;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b0810;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b0810;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b0810;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b0810;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b0810;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b0810;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b0810;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b0810;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b0810;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b0810;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b0810;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b0810;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b0810;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b0810;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b0810;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b0810;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b0810;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b0810;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b0810;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b0810;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b0810;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b0810;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b0810;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b0810;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b0810;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b0810;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b0810;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b0810;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b0810;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b0810;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b0810;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b0810;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b0810;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b0810;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b0810;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b0810;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b0810;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b0810;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b0810;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b0810;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b0810;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b0810;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b0810;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b0811;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b0811;;acald_e <=> acald_c;0.0;0.0
ACKr;b0811;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b0811;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b0811;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b0811;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b0811;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b0811;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b0811;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b0811;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b0811;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b0811;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b0811;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b0811;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b0811;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b0811;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b0811;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b0811;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b0811;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b0811;;ac_e --> ;0.0;0.0
EX_acald_e;b0811;;acald_e --> ;0.0;0.0
EX_akg_e;b0811;;akg_e --> ;0.0;0.0
EX_co2_e;b0811;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b0811;;etoh_e --> ;0.0;0.0
EX_for_e;b0811;;for_e --> ;0.0;0.0
EX_fru_e;b0811;;fru_e --> ;0.0;0.0
EX_fum_e;b0811;;fum_e --> ;0.0;0.0
EX_glc__D_e;b0811;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b0811;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b0811;;glu__L_e --> ;0.0;0.0
EX_h_e;b0811;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b0811;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b0811;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b0811;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b0811;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b0811;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b0811;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b0811;;pyr_e --> ;0.0;0.0
EX_succ_e;b0811;;succ_e --> ;0.0;0.0
FBA;b0811;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b0811;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b0811;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b0811;;for_c --> for_e;0.0;0.0
FRD7;b0811;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b0811;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b0811;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b0811;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b0811;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b0811;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b0811;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b0811;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b0811;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b0811;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b0811;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b0811;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b0811;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b0811;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b0811;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b0811;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b0811;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b0811;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b0811;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b0811;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b0811;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b0811;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b0811;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b0811;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b0811;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b0811;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b0811;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b0811;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b0811;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b0811;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b0811;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b0811;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b0811;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b0811;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b0811;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b0811;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b0811;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b0811;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b0811;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b0811;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b0811;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b0811;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b0811;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b0811;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b0811;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b0811;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b0811;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b0811;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b0811;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b0811;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b0811;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b0811;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b1761;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b1761;;acald_e <=> acald_c;0.0;0.0
ACKr;b1761;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b1761;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.471170359316124
ACONTb;b1761;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.471170359316125
ACt2r;b1761;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b1761;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b1761;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.552607281477905
AKGt2r;b1761;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b1761;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b1761;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b1761;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;47.74394391135162
Biomass_Ecoli_core;b1761;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.851388523346209
CO2t;b1761;;co2_e <=> co2_c;-22.809833310205086;-23.76873569474045
CS;b1761;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.471170359316125
CYTBD;b1761;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;45.5688908457998
D_LACt2;b1761;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b1761;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.955512411018093
ETOHt2r;b1761;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b1761;;ac_e --> ;0.0;0.0
EX_acald_e;b1761;;acald_e --> ;0.0;0.0
EX_akg_e;b1761;;akg_e --> ;0.0;0.0
EX_co2_e;b1761;;co2_e <=> ;22.809833310205086;23.76873569474045
EX_etoh_e;b1761;;etoh_e --> ;0.0;0.0
EX_for_e;b1761;;for_e --> ;0.0;0.0
EX_fru_e;b1761;;fru_e --> ;0.0;0.0
EX_fum_e;b1761;;fum_e --> ;0.0;0.0
EX_glc__D_e;b1761;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b1761;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b1761;;glu__L_e --> ;0.0;0.0
EX_h_e;b1761;;h_e <=> ;17.530865429786523;17.078853778325005
EX_h2o_e;b1761;;h2o_e <=> ;29.175827135565836;29.970590254203575
EX_lac__D_e;b1761;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b1761;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b1761;;nh4_e <=> ;-4.765319193197444;-4.642451340102205
EX_o2_e;b1761;;o2_e <=> ;-21.799492655998886;-22.784445422899896
EX_pi_e;b1761;;pi_e <=> ;-3.214895047684769;-3.132002960833728
EX_pyr_e;b1761;;pyr_e --> ;0.0;0.0
EX_succ_e;b1761;;succ_e --> ;0.0;0.0
FBA;b1761;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.645559589382772
FBP;b1761;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b1761;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b1761;;for_c --> for_e;0.0;0.0
FRD7;b1761;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b1761;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b1761;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.552607281477904
FUMt2_2;b1761;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b1761;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.522692739334265
GAPD;b1761;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.22918964194402
GLCpts;b1761;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b1761;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;4.642451340102205
GLNabc;b1761;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b1761;;glu__L_c + h2o_c + nadp_c --> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;0.0
GLUN;b1761;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b1761;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;4.424751294682581
GLUt2r;b1761;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b1761;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.522692739334264
H2Ot;b1761;;h2o_e <=> h2o_c;-29.175827135565836;-29.970590254203575
ICDHyr;b1761;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.471170359316125
ICL;b1761;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b1761;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b1761;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b1761;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b1761;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.552607281477904
ME1;b1761;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b1761;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b1761;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;40.01628356432189
NADTRHD;b1761;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b1761;;nh4_e <=> nh4_c;4.765319193197444;4.642451340102205
O2t;b1761;;o2_e <=> o2_c;21.799492655998886;22.784445422899896
PDH;b1761;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.662004267113048
PFK;b1761;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.645559589382773
PFL;b1761;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b1761;;g6p_c <=> f6p_c;4.860861146496871;5.302772613379765
PGK;b1761;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.229189641944025
PGL;b1761;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.522692739334265
PGM;b1761;;2pg_c <=> 3pg_c;-14.716139568742859;-14.955512411018093
PIt2r;b1761;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.132002960833728
PPC;b1761;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.439738952500888
PPCK;b1761;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b1761;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b1761;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b1761;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;2.073817676048187
PYRt2;b1761;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b1761;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.4031504223082547
RPI;b1761;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.1195423170260104
SUCCt2_2;b1761;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b1761;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b1761;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.552607281477905
SUCOAS;b1761;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.552607281477905
TALA;b1761;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.3552508396181182
THD2;b1761;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b1761;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.355250839618118
TKT2;b1761;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.0478995826901367
TPI;b1761;;dhap_c <=> g3p_c;7.477381962160304;7.645559589382772
ACALD;b1524;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b1524;;acald_e <=> acald_c;0.0;0.0
ACKr;b1524;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b1524;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350328
ACONTb;b1524;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350328
ACt2r;b1524;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b1524;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b1524;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482091
AKGt2r;b1524;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b1524;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b1524;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b1524;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517454
Biomass_Ecoli_core;b1524;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684306
CO2t;b1524;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b1524;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350327
CYTBD;b1524;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199751
D_LACt2;b1524;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b1524;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742825
ETOHt2r;b1524;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b1524;;ac_e --> ;0.0;0.0
EX_acald_e;b1524;;acald_e --> ;0.0;0.0
EX_akg_e;b1524;;akg_e --> ;0.0;0.0
EX_co2_e;b1524;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b1524;;etoh_e --> ;0.0;0.0
EX_for_e;b1524;;for_e --> ;0.0;0.0
EX_fru_e;b1524;;fru_e --> ;0.0;0.0
EX_fum_e;b1524;;fum_e --> ;0.0;0.0
EX_glc__D_e;b1524;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b1524;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b1524;;glu__L_e --> ;0.0;0.0
EX_h_e;b1524;;h_e <=> ;17.530865429786523;17.530865429786708
EX_h2o_e;b1524;;h2o_e <=> ;29.175827135565836;29.17582713556576
EX_lac__D_e;b1524;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b1524;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b1524;;nh4_e <=> ;-4.765319193197444;-4.765319193197458
EX_o2_e;b1524;;o2_e <=> ;-21.799492655998886;-21.79949265599875
EX_pi_e;b1524;;pi_e <=> ;-3.214895047684769;-3.214895047684734
EX_pyr_e;b1524;;pyr_e --> ;0.0;0.0
EX_succ_e;b1524;;succ_e --> ;0.0;0.0
FBA;b1524;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160276
FBP;b1524;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b1524;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b1524;;for_c --> for_e;0.0;0.0
FRD7;b1524;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b1524;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b1524;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.0643756614820905
FUMt2_2;b1524;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b1524;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574679
GAPD;b1524;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167597
GLCpts;b1524;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b1524;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182648
GLNabc;b1524;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b1524;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.541857463865632
GLUN;b1524;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b1524;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b1524;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b1524;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.959984944574678
H2Ot;b1524;;h2o_e <=> h2o_c;-29.175827135565836;-29.17582713556576
ICDHyr;b1524;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350328
ICL;b1524;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b1524;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b1524;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b1524;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b1524;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.0643756614820905
ME1;b1524;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b1524;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b1524;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515414
NADTRHD;b1524;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b1524;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b1524;;o2_e <=> o2_c;21.799492655998886;21.79949265599875
PDH;b1524;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916661
PFK;b1524;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160277
PFL;b1524;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b1524;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496793
PGK;b1524;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.0235261431676
PGL;b1524;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574679
PGM;b1524;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742825
PIt2r;b1524;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684734
PPC;b1524;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687308
PPCK;b1524;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b1524;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b1524;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b1524;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067795
PYRt2;b1524;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b1524;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.6784818505075445
RPI;b1524;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671344
SUCCt2_2;b1524;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b1524;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b1524;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482091
SUCOAS;b1524;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482091
TALA;b1524;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.496983757261574
THD2;b1524;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b1524;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.496983757261574
TKT2;b1524;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.1814980932459709
TPI;b1524;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160276
ACALD;b1812;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b1812;;acald_e <=> acald_c;0.0;0.0
ACKr;b1812;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b1812;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b1812;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b1812;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b1812;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b1812;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b1812;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b1812;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b1812;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b1812;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b1812;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b1812;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b1812;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b1812;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b1812;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b1812;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b1812;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b1812;;ac_e --> ;0.0;0.0
EX_acald_e;b1812;;acald_e --> ;0.0;0.0
EX_akg_e;b1812;;akg_e --> ;0.0;0.0
EX_co2_e;b1812;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b1812;;etoh_e --> ;0.0;0.0
EX_for_e;b1812;;for_e --> ;0.0;0.0
EX_fru_e;b1812;;fru_e --> ;0.0;0.0
EX_fum_e;b1812;;fum_e --> ;0.0;0.0
EX_glc__D_e;b1812;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b1812;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b1812;;glu__L_e --> ;0.0;0.0
EX_h_e;b1812;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b1812;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b1812;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b1812;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b1812;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b1812;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b1812;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b1812;;pyr_e --> ;0.0;0.0
EX_succ_e;b1812;;succ_e --> ;0.0;0.0
FBA;b1812;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b1812;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b1812;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b1812;;for_c --> for_e;0.0;0.0
FRD7;b1812;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b1812;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b1812;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b1812;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b1812;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b1812;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b1812;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b1812;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b1812;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b1812;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b1812;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b1812;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b1812;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b1812;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b1812;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b1812;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b1812;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b1812;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b1812;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b1812;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b1812;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b1812;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b1812;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b1812;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b1812;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b1812;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b1812;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b1812;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b1812;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b1812;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b1812;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b1812;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b1812;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b1812;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b1812;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b1812;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b1812;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b1812;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b1812;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b1812;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b1812;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b1812;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b1812;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b1812;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b1812;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b1812;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b1812;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b1812;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b1812;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b1812;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b1812;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b1812;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b0485;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b0485;;acald_e <=> acald_c;0.0;0.0
ACKr;b0485;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b0485;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b0485;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b0485;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b0485;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b0485;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b0485;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b0485;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b0485;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b0485;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b0485;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b0485;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b0485;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b0485;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b0485;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b0485;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b0485;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b0485;;ac_e --> ;0.0;0.0
EX_acald_e;b0485;;acald_e --> ;0.0;0.0
EX_akg_e;b0485;;akg_e --> ;0.0;0.0
EX_co2_e;b0485;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b0485;;etoh_e --> ;0.0;0.0
EX_for_e;b0485;;for_e --> ;0.0;0.0
EX_fru_e;b0485;;fru_e --> ;0.0;0.0
EX_fum_e;b0485;;fum_e --> ;0.0;0.0
EX_glc__D_e;b0485;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b0485;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b0485;;glu__L_e --> ;0.0;0.0
EX_h_e;b0485;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b0485;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b0485;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b0485;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b0485;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b0485;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b0485;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b0485;;pyr_e --> ;0.0;0.0
EX_succ_e;b0485;;succ_e --> ;0.0;0.0
FBA;b0485;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b0485;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b0485;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b0485;;for_c --> for_e;0.0;0.0
FRD7;b0485;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b0485;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b0485;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b0485;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b0485;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b0485;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b0485;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b0485;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b0485;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b0485;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b0485;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b0485;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b0485;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b0485;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b0485;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b0485;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b0485;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b0485;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b0485;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b0485;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b0485;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b0485;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b0485;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b0485;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b0485;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b0485;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b0485;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b0485;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b0485;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b0485;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b0485;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b0485;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b0485;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b0485;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b0485;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b0485;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b0485;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b0485;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b0485;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b0485;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b0485;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b0485;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b0485;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b0485;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b0485;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b0485;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b0485;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b0485;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b0485;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b0485;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b0485;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b0485;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b3213;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b3213;;acald_e <=> acald_c;0.0;0.0
ACKr;b3213;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b3213;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b3213;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b3213;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b3213;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b3213;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b3213;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b3213;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b3213;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b3213;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b3213;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b3213;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b3213;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b3213;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b3213;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b3213;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b3213;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b3213;;ac_e --> ;0.0;0.0
EX_acald_e;b3213;;acald_e --> ;0.0;0.0
EX_akg_e;b3213;;akg_e --> ;0.0;0.0
EX_co2_e;b3213;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b3213;;etoh_e --> ;0.0;0.0
EX_for_e;b3213;;for_e --> ;0.0;0.0
EX_fru_e;b3213;;fru_e --> ;0.0;0.0
EX_fum_e;b3213;;fum_e --> ;0.0;0.0
EX_glc__D_e;b3213;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b3213;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b3213;;glu__L_e --> ;0.0;0.0
EX_h_e;b3213;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b3213;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b3213;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b3213;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b3213;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b3213;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b3213;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b3213;;pyr_e --> ;0.0;0.0
EX_succ_e;b3213;;succ_e --> ;0.0;0.0
FBA;b3213;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b3213;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b3213;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b3213;;for_c --> for_e;0.0;0.0
FRD7;b3213;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b3213;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b3213;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b3213;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b3213;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b3213;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b3213;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b3213;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b3213;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b3213;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b3213;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b3213;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b3213;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b3213;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b3213;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b3213;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b3213;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b3213;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b3213;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b3213;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b3213;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b3213;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b3213;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b3213;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b3213;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b3213;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b3213;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b3213;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b3213;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b3213;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b3213;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b3213;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b3213;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b3213;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b3213;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b3213;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b3213;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b3213;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b3213;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b3213;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b3213;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b3213;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b3213;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b3213;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b3213;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b3213;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b3213;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b3213;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b3213;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b3213;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b3213;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b3213;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b3212;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b3212;;acald_e <=> acald_c;0.0;0.0
ACKr;b3212;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b3212;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b3212;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b3212;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b3212;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b3212;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b3212;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b3212;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b3212;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b3212;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b3212;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b3212;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b3212;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b3212;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b3212;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b3212;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b3212;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b3212;;ac_e --> ;0.0;0.0
EX_acald_e;b3212;;acald_e --> ;0.0;0.0
EX_akg_e;b3212;;akg_e --> ;0.0;0.0
EX_co2_e;b3212;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b3212;;etoh_e --> ;0.0;0.0
EX_for_e;b3212;;for_e --> ;0.0;0.0
EX_fru_e;b3212;;fru_e --> ;0.0;0.0
EX_fum_e;b3212;;fum_e --> ;0.0;0.0
EX_glc__D_e;b3212;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b3212;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b3212;;glu__L_e --> ;0.0;0.0
EX_h_e;b3212;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b3212;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b3212;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b3212;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b3212;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b3212;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b3212;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b3212;;pyr_e --> ;0.0;0.0
EX_succ_e;b3212;;succ_e --> ;0.0;0.0
FBA;b3212;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b3212;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b3212;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b3212;;for_c --> for_e;0.0;0.0
FRD7;b3212;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b3212;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b3212;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b3212;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b3212;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b3212;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b3212;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b3212;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b3212;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b3212;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b3212;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b3212;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b3212;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b3212;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b3212;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b3212;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b3212;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b3212;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b3212;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b3212;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b3212;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b3212;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b3212;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b3212;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b3212;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b3212;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b3212;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b3212;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b3212;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b3212;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b3212;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b3212;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b3212;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b3212;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b3212;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b3212;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b3212;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b3212;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b3212;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b3212;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b3212;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b3212;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b3212;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b3212;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b3212;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b3212;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b3212;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b3212;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b3212;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b3212;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b3212;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b3212;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b4077;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b4077;;acald_e <=> acald_c;0.0;0.0
ACKr;b4077;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b4077;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b4077;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b4077;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b4077;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b4077;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b4077;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b4077;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b4077;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b4077;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b4077;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b4077;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b4077;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b4077;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b4077;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b4077;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b4077;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b4077;;ac_e --> ;0.0;0.0
EX_acald_e;b4077;;acald_e --> ;0.0;0.0
EX_akg_e;b4077;;akg_e --> ;0.0;0.0
EX_co2_e;b4077;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b4077;;etoh_e --> ;0.0;0.0
EX_for_e;b4077;;for_e --> ;0.0;0.0
EX_fru_e;b4077;;fru_e --> ;0.0;0.0
EX_fum_e;b4077;;fum_e --> ;0.0;0.0
EX_glc__D_e;b4077;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b4077;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b4077;;glu__L_e --> ;0.0;0.0
EX_h_e;b4077;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b4077;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b4077;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b4077;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b4077;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b4077;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b4077;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b4077;;pyr_e --> ;0.0;0.0
EX_succ_e;b4077;;succ_e --> ;0.0;0.0
FBA;b4077;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b4077;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b4077;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b4077;;for_c --> for_e;0.0;0.0
FRD7;b4077;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b4077;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b4077;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b4077;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b4077;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b4077;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b4077;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b4077;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b4077;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b4077;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b4077;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b4077;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b4077;;glu__L_e + h_e --> glu__L_c + h_c;0.0;0.0
GND;b4077;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b4077;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b4077;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b4077;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b4077;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b4077;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b4077;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b4077;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b4077;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b4077;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b4077;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b4077;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b4077;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b4077;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b4077;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b4077;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b4077;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b4077;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b4077;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b4077;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b4077;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b4077;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b4077;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b4077;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b4077;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b4077;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b4077;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b4077;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b4077;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b4077;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b4077;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b4077;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b4077;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b4077;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b4077;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b4077;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b4077;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b4077;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b4077;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b2029;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b2029;;acald_e <=> acald_c;0.0;0.0
ACKr;b2029;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b2029;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;7.803301595127319
ACONTb;b2029;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;7.80330159512732
ACt2r;b2029;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b2029;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b2029;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;6.871333415503454
AKGt2r;b2029;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b2029;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b2029;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b2029;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;41.35354605121254
Biomass_Ecoli_core;b2029;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.863813309504001
CO2t;b2029;;co2_e <=> co2_c;-22.809833310205086;-23.239992707402525
CS;b2029;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;7.803301595127319
CYTBD;b2029;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;44.48267628056989
D_LACt2;b2029;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b2029;;2pg_c <=> h2o_c + pep_c;14.716139568742859;16.411460368327536
ETOHt2r;b2029;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b2029;;ac_e --> ;0.0;0.0
EX_acald_e;b2029;;acald_e --> ;0.0;0.0
EX_akg_e;b2029;;akg_e --> ;0.0;0.0
EX_co2_e;b2029;;co2_e <=> ;22.809833310205086;23.239992707402525
EX_etoh_e;b2029;;etoh_e --> ;0.0;0.0
EX_for_e;b2029;;for_e --> ;0.0;0.0
EX_fru_e;b2029;;fru_e --> ;0.0;0.0
EX_fum_e;b2029;;fum_e --> ;0.0;0.0
EX_glc__D_e;b2029;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b2029;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b2029;;glu__L_e --> ;0.0;0.0
EX_h_e;b2029;;h_e <=> ;17.530865429786523;17.328094988650292
EX_h2o_e;b2029;;h2o_e <=> ;29.175827135565836;29.53235437915348
EX_lac__D_e;b2029;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b2029;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b2029;;nh4_e <=> ;-4.765319193197444;-4.7102012140634155
EX_o2_e;b2029;;o2_e <=> ;-21.799492655998886;-22.24133814028494
EX_pi_e;b2029;;pi_e <=> ;-3.214895047684769;-3.1777100216723975
EX_pyr_e;b2029;;pyr_e --> ;0.0;0.0
EX_succ_e;b2029;;succ_e --> ;0.0;0.0
FBA;b2029;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;9.140764901036372
FBP;b2029;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b2029;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b2029;;for_c --> for_e;0.0;0.0
FRD7;b2029;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b2029;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b2029;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;6.871333415503454
FUMt2_2;b2029;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b2029;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;0.0
GAPD;b2029;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;17.70372507934552
GLCpts;b2029;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b2029;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22087706324017306
GLNabc;b2029;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b2029;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.489324150823243
GLUN;b2029;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b2029;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b2029;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b2029;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;0.0
H2Ot;b2029;;h2o_e <=> h2o_c;-29.175827135565836;-29.53235437915348
ICDHyr;b2029;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;7.803301595127319
ICL;b2029;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b2029;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b2029;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b2029;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b2029;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;6.871333415503454
ME1;b2029;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b2029;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b2029;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;37.61134286506643
NADTRHD;b2029;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b2029;;nh4_e <=> nh4_c;4.765319193197444;4.7102012140634155
O2t;b2029;;o2_e <=> o2_c;21.799492655998886;22.24133814028494
PDH;b2029;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;11.040701116486412
PFK;b2029;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;9.140764901036372
PFL;b2029;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b2029;;g6p_c <=> f6p_c;4.860861146496871;9.82291827155168
PGK;b2029;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-17.70372507934552
PGL;b2029;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;0.0
PGM;b2029;;2pg_c <=> 3pg_c;-14.716139568742859;-16.411460368327536
PIt2r;b2029;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.1777100216723975
PPC;b2029;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.4753434197146587
PPCK;b2029;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b2029;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b2029;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b2029;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;3.4877114596493457
PYRt2;b2029;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b2029;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;-0.6209090068714763
RPI;b2029;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-0.6209090068714764
SUCCt2_2;b2029;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b2029;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b2029;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;6.871333415503454
SUCOAS;b2029;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-6.871333415503454
TALA;b2029;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;-0.15453620107026592
THD2;b2029;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;7.9396959705831085
TKT1;b2029;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;-0.1545362010702659
TKT2;b2029;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;-0.4663728058012104
TPI;b2029;;dhap_c <=> g3p_c;7.477381962160304;9.140764901036372
ACALD;b0875;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b0875;;acald_e <=> acald_c;0.0;0.0
ACKr;b0875;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b0875;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350332
ACONTb;b0875;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.0072495753503325
ACt2r;b0875;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b0875;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b0875;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482096
AKGt2r;b0875;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b0875;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b0875;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b0875;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.51400977451748
Biomass_Ecoli_core;b0875;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684311
CO2t;b0875;;co2_e <=> co2_c;-22.809833310205086;-22.809833310204976
CS;b0875;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350331
CYTBD;b0875;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199754
D_LACt2;b0875;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b0875;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.71613956874283
ETOHt2r;b0875;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b0875;;ac_e --> ;0.0;0.0
EX_acald_e;b0875;;acald_e --> ;0.0;0.0
EX_akg_e;b0875;;akg_e --> ;0.0;0.0
EX_co2_e;b0875;;co2_e <=> ;22.809833310205086;22.809833310204976
EX_etoh_e;b0875;;etoh_e --> ;0.0;0.0
EX_for_e;b0875;;for_e --> ;0.0;0.0
EX_fru_e;b0875;;fru_e --> ;0.0;0.0
EX_fum_e;b0875;;fum_e --> ;0.0;0.0
EX_glc__D_e;b0875;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b0875;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b0875;;glu__L_e --> ;0.0;0.0
EX_h_e;b0875;;h_e <=> ;17.530865429786523;17.530865429786658
EX_h2o_e;b0875;;h2o_e <=> ;29.175827135565836;29.175827135565804
EX_lac__D_e;b0875;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b0875;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b0875;;nh4_e <=> ;-4.765319193197444;-4.76531919319746
EX_o2_e;b0875;;o2_e <=> ;-21.799492655998886;-21.799492655998765
EX_pi_e;b0875;;pi_e <=> ;-3.214895047684769;-3.2148950476847737
EX_pyr_e;b0875;;pyr_e --> ;0.0;0.0
EX_succ_e;b0875;;succ_e --> ;0.0;0.0
FBA;b0875;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.4773819621602815
FBP;b0875;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b0875;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b0875;;for_c --> for_e;0.0;0.0
FRD7;b0875;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b0875;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b0875;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482096
FUMt2_2;b0875;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b0875;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574662
GAPD;b0875;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167604
GLCpts;b0875;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b0875;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182779
GLNabc;b0875;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b0875;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.541857463865632
GLUN;b0875;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b0875;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b0875;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b0875;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.959984944574661
H2Ot;b0875;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565804
ICDHyr;b0875;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350332
ICL;b0875;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b0875;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b0875;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b0875;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b0875;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482096
ME1;b0875;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b0875;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b0875;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b0875;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b0875;;nh4_e <=> nh4_c;4.765319193197444;4.76531919319746
O2t;b0875;;o2_e <=> o2_c;21.799492655998886;21.799492655998765
PDH;b0875;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.282532599166617
PFK;b0875;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160282
PFL;b0875;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b0875;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496811
PGK;b0875;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.023526143167608
PGL;b0875;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.9599849445746615
PGM;b0875;;2pg_c <=> 3pg_c;-14.716139568742859;-14.71613956874283
PIt2r;b0875;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.2148950476847737
PPC;b0875;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.504309470368731
PPCK;b0875;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b0875;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b0875;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b0875;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067861
PYRt2;b0875;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b0875;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.6784818505075316
RPI;b0875;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671295
SUCCt2_2;b0875;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b0875;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b0875;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482097
SUCOAS;b0875;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482097
TALA;b0875;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615678
THD2;b0875;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b0875;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615676
TKT2;b0875;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.1814980932459647
TPI;b0875;;dhap_c <=> g3p_c;7.477381962160304;7.4773819621602815
ACALD;b1136;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b1136;;acald_e <=> acald_c;0.0;0.0
ACKr;b1136;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b1136;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;10.000000000000034
ACONTb;b1136;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;10.000000000000034
ACt2r;b1136;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b1136;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b1136;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0
AKGt2r;b1136;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b1136;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b1136;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;75.00000000000034
ATPS4r;b1136;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;55.00000000000006
Biomass_Ecoli_core;b1136;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;-3.642223560848925e-15
CO2t;b1136;;co2_e <=> co2_c;-22.809833310205086;-20.000000000000018
CS;b1136;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;10.00000000000003
CYTBD;b1136;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;50.00000000000007
D_LACt2;b1136;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b1136;;2pg_c <=> h2o_c + pep_c;14.716139568742859;20.00000000000003
ETOHt2r;b1136;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b1136;;ac_e --> ;0.0;0.0
EX_acald_e;b1136;;acald_e --> ;0.0;0.0
EX_akg_e;b1136;;akg_e --> ;0.0;0.0
EX_co2_e;b1136;;co2_e <=> ;22.809833310205086;20.000000000000018
EX_etoh_e;b1136;;etoh_e --> ;0.0;0.0
EX_for_e;b1136;;for_e --> ;0.0;0.0
EX_fru_e;b1136;;fru_e --> ;0.0;0.0
EX_fum_e;b1136;;fum_e --> ;0.0;0.0
EX_glc__D_e;b1136;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b1136;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b1136;;glu__L_e --> ;0.0;0.0
EX_h_e;b1136;;h_e <=> ;17.530865429786523;20.000000000000068
EX_h2o_e;b1136;;h2o_e <=> ;29.175827135565836;30.00000000000001
EX_lac__D_e;b1136;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b1136;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b1136;;nh4_e <=> ;-4.765319193197444;1.9860316632597014e-14
EX_o2_e;b1136;;o2_e <=> ;-21.799492655998886;-25.000000000000036
EX_pi_e;b1136;;pi_e <=> ;-3.214895047684769;-2.1139181008574163e-15
EX_pyr_e;b1136;;pyr_e --> ;0.0;0.0
EX_succ_e;b1136;;succ_e --> ;0.0;10.000000000000052
FBA;b1136;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;10.000000000000014
FBP;b1136;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b1136;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b1136;;for_c --> for_e;0.0;0.0
FRD7;b1136;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b1136;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b1136;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;-1.646233710882624e-14
FUMt2_2;b1136;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b1136;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;-3.117390560978087e-14
GAPD;b1136;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;20.000000000000025
GLCpts;b1136;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b1136;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;-9.3131656450907e-16
GLNabc;b1136;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b1136;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;1.8929000068087943e-14
GLUN;b1136;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b1136;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b1136;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b1136;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;-3.1173905609780864e-14
H2Ot;b1136;;h2o_e <=> h2o_c;-29.175827135565836;-30.00000000000001
ICDHyr;b1136;;icit_c + nadp_c --> akg_c + co2_c + nadph_c;6.007249575350396;0.0
ICL;b1136;;icit_c --> glx_c + succ_c;0.0;10.000000000000034
LDH_D;b1136;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b1136;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;10.000000000000034
MALt2_2;b1136;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b1136;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;10.000000000000018
ME1;b1136;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b1136;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b1136;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;50.00000000000008
NADTRHD;b1136;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b1136;;nh4_e <=> nh4_c;4.765319193197444;-1.9860316632597014e-14
O2t;b1136;;o2_e <=> o2_c;21.799492655998886;25.000000000000036
PDH;b1136;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;20.000000000000046
PFK;b1136;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;10.000000000000016
PFL;b1136;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b1136;;g6p_c <=> f6p_c;4.860861146496871;10.000000000000034
PGK;b1136;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-20.000000000000025
PGL;b1136;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;-3.117390560978087e-14
PGM;b1136;;2pg_c <=> 3pg_c;-14.716139568742859;-20.00000000000003
PIt2r;b1136;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;2.1139181008574163e-15
PPC;b1136;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;0.0
PPCK;b1136;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b1136;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b1136;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b1136;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;10.000000000000036
PYRt2;b1136;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b1136;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;-2.0888979484461287e-14
RPI;b1136;;r5p_c <=> ru5p__D_c;-2.2815030940671064;1.028492612531958e-14
SUCCt2_2;b1136;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b1136;;h_e + succ_c --> h_c + succ_e;0.0;10.000000000000052
SUCDi;b1136;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;-1.5948213258617017e-14
SUCOAS;b1136;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-2.275026620207604e-15
TALA;b1136;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;-1.2464114115036669e-14
THD2;b1136;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b1136;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;-1.2464114115036668e-14
TKT2;b1136;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;-8.42486536942462e-15
TPI;b1136;;dhap_c <=> g3p_c;7.477381962160304;10.000000000000014
ACALD;b4015;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b4015;;acald_e <=> acald_c;0.0;0.0
ACKr;b4015;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b4015;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b4015;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b4015;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b4015;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b4015;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.0643756614820985
AKGt2r;b4015;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b4015;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b4015;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b4015;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.51400977451746
Biomass_Ecoli_core;b4015;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684313
CO2t;b4015;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b4015;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350331
CYTBD;b4015;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b4015;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b4015;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742824
ETOHt2r;b4015;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b4015;;ac_e --> ;0.0;0.0
EX_acald_e;b4015;;acald_e --> ;0.0;0.0
EX_akg_e;b4015;;akg_e --> ;0.0;0.0
EX_co2_e;b4015;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b4015;;etoh_e --> ;0.0;0.0
EX_for_e;b4015;;for_e --> ;0.0;0.0
EX_fru_e;b4015;;fru_e --> ;0.0;0.0
EX_fum_e;b4015;;fum_e --> ;0.0;0.0
EX_glc__D_e;b4015;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b4015;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b4015;;glu__L_e --> ;0.0;0.0
EX_h_e;b4015;;h_e <=> ;17.530865429786523;17.53086542978669
EX_h2o_e;b4015;;h2o_e <=> ;29.175827135565836;29.17582713556576
EX_lac__D_e;b4015;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b4015;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b4015;;nh4_e <=> ;-4.765319193197444;-4.76531919319746
EX_o2_e;b4015;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b4015;;pi_e <=> ;-3.214895047684769;-3.214895047684771
EX_pyr_e;b4015;;pyr_e --> ;0.0;0.0
EX_succ_e;b4015;;succ_e --> ;0.0;0.0
FBA;b4015;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160281
FBP;b4015;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b4015;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b4015;;for_c --> for_e;0.0;0.0
FRD7;b4015;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b4015;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b4015;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482101
FUMt2_2;b4015;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b4015;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574662
GAPD;b4015;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167597
GLCpts;b4015;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b4015;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182784
GLNabc;b4015;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b4015;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.541857463865632
GLUN;b4015;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b4015;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b4015;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b4015;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.959984944574661
H2Ot;b4015;;h2o_e <=> h2o_c;-29.175827135565836;-29.17582713556576
ICDHyr;b4015;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b4015;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b4015;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b4015;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;-6.379285303446807e-15
MALt2_2;b4015;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b4015;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482095
ME1;b4015;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b4015;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b4015;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.53460965051542
NADTRHD;b4015;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b4015;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197461
O2t;b4015;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b4015;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.282532599166608
PFK;b4015;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.4773819621602815
PFL;b4015;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b4015;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496811
PGK;b4015;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.0235261431676
PGL;b4015;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.9599849445746615
PGM;b4015;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742824
PIt2r;b4015;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684771
PPC;b4015;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687316
PPCK;b4015;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b4015;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b4015;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b4015;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067786
PYRt2;b4015;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b4015;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507532
RPI;b4015;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671295
SUCCt2_2;b4015;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b4015;;h_e + succ_c --> h_c + succ_e;0.0;-2.3922319887925524e-15
SUCDi;b4015;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482101
SUCOAS;b4015;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.0643756614820985
TALA;b4015;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615676
THD2;b4015;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b4015;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615676
TKT2;b4015;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.1814980932459642
TPI;b4015;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160281
ACALD;b2133;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b2133;;acald_e <=> acald_c;0.0;0.0
ACKr;b2133;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b2133;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b2133;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b2133;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b2133;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b2133;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b2133;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b2133;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b2133;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b2133;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b2133;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b2133;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b2133;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b2133;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b2133;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b2133;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b2133;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b2133;;ac_e --> ;0.0;0.0
EX_acald_e;b2133;;acald_e --> ;0.0;0.0
EX_akg_e;b2133;;akg_e --> ;0.0;0.0
EX_co2_e;b2133;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b2133;;etoh_e --> ;0.0;0.0
EX_for_e;b2133;;for_e --> ;0.0;0.0
EX_fru_e;b2133;;fru_e --> ;0.0;0.0
EX_fum_e;b2133;;fum_e --> ;0.0;0.0
EX_glc__D_e;b2133;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b2133;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b2133;;glu__L_e --> ;0.0;0.0
EX_h_e;b2133;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b2133;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b2133;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b2133;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b2133;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b2133;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b2133;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b2133;;pyr_e --> ;0.0;0.0
EX_succ_e;b2133;;succ_e --> ;0.0;0.0
FBA;b2133;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b2133;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b2133;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b2133;;for_c --> for_e;0.0;0.0
FRD7;b2133;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b2133;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b2133;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b2133;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b2133;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b2133;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b2133;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b2133;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b2133;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b2133;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b2133;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b2133;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b2133;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b2133;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b2133;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b2133;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b2133;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b2133;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b2133;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b2133;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b2133;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b2133;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b2133;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b2133;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b2133;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b2133;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b2133;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b2133;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b2133;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b2133;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b2133;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b2133;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b2133;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b2133;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b2133;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b2133;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b2133;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b2133;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b2133;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b2133;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b2133;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b2133;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b2133;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b2133;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b2133;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b2133;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b2133;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b2133;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b2133;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b2133;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b2133;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b2133;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b1380;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b1380;;acald_e <=> acald_c;0.0;0.0
ACKr;b1380;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b1380;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b1380;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b1380;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b1380;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b1380;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b1380;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b1380;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b1380;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b1380;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b1380;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b1380;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b1380;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b1380;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b1380;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b1380;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b1380;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b1380;;ac_e --> ;0.0;0.0
EX_acald_e;b1380;;acald_e --> ;0.0;0.0
EX_akg_e;b1380;;akg_e --> ;0.0;0.0
EX_co2_e;b1380;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b1380;;etoh_e --> ;0.0;0.0
EX_for_e;b1380;;for_e --> ;0.0;0.0
EX_fru_e;b1380;;fru_e --> ;0.0;0.0
EX_fum_e;b1380;;fum_e --> ;0.0;0.0
EX_glc__D_e;b1380;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b1380;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b1380;;glu__L_e --> ;0.0;0.0
EX_h_e;b1380;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b1380;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b1380;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b1380;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b1380;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b1380;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b1380;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b1380;;pyr_e --> ;0.0;0.0
EX_succ_e;b1380;;succ_e --> ;0.0;0.0
FBA;b1380;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b1380;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b1380;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b1380;;for_c --> for_e;0.0;0.0
FRD7;b1380;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b1380;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b1380;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b1380;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b1380;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b1380;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b1380;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b1380;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b1380;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b1380;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b1380;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b1380;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b1380;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b1380;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b1380;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b1380;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b1380;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b1380;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b1380;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b1380;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b1380;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b1380;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b1380;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b1380;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b1380;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b1380;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b1380;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b1380;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b1380;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b1380;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b1380;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b1380;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b1380;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b1380;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b1380;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b1380;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b1380;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b1380;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b1380;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b1380;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b1380;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b1380;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b1380;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b1380;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b1380;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b1380;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b1380;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b1380;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b1380;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b1380;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b1380;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b1380;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b4014;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b4014;;acald_e <=> acald_c;0.0;0.0
ACKr;b4014;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b4014;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b4014;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b4014;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b4014;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b4014;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b4014;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b4014;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b4014;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b4014;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b4014;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b4014;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b4014;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b4014;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b4014;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b4014;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b4014;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b4014;;ac_e --> ;0.0;0.0
EX_acald_e;b4014;;acald_e --> ;0.0;0.0
EX_akg_e;b4014;;akg_e --> ;0.0;0.0
EX_co2_e;b4014;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b4014;;etoh_e --> ;0.0;0.0
EX_for_e;b4014;;for_e --> ;0.0;0.0
EX_fru_e;b4014;;fru_e --> ;0.0;0.0
EX_fum_e;b4014;;fum_e --> ;0.0;0.0
EX_glc__D_e;b4014;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b4014;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b4014;;glu__L_e --> ;0.0;0.0
EX_h_e;b4014;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b4014;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b4014;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b4014;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b4014;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b4014;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b4014;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b4014;;pyr_e --> ;0.0;0.0
EX_succ_e;b4014;;succ_e --> ;0.0;0.0
FBA;b4014;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b4014;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b4014;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b4014;;for_c --> for_e;0.0;0.0
FRD7;b4014;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b4014;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b4014;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b4014;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b4014;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b4014;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b4014;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b4014;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b4014;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b4014;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b4014;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b4014;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b4014;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b4014;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b4014;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b4014;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b4014;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b4014;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b4014;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b4014;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b4014;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b4014;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b4014;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b4014;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b4014;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b4014;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b4014;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b4014;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b4014;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b4014;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b4014;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b4014;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b4014;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b4014;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b4014;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b4014;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b4014;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b4014;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b4014;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b4014;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b4014;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b4014;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b4014;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b4014;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b4014;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b4014;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b4014;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b4014;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b4014;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b4014;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b4014;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b4014;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b2976;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b2976;;acald_e <=> acald_c;0.0;0.0
ACKr;b2976;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b2976;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b2976;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b2976;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b2976;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b2976;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b2976;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b2976;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b2976;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b2976;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b2976;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b2976;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b2976;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b2976;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b2976;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b2976;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b2976;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b2976;;ac_e --> ;0.0;0.0
EX_acald_e;b2976;;acald_e --> ;0.0;0.0
EX_akg_e;b2976;;akg_e --> ;0.0;0.0
EX_co2_e;b2976;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b2976;;etoh_e --> ;0.0;0.0
EX_for_e;b2976;;for_e --> ;0.0;0.0
EX_fru_e;b2976;;fru_e --> ;0.0;0.0
EX_fum_e;b2976;;fum_e --> ;0.0;0.0
EX_glc__D_e;b2976;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b2976;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b2976;;glu__L_e --> ;0.0;0.0
EX_h_e;b2976;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b2976;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b2976;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b2976;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b2976;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b2976;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b2976;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b2976;;pyr_e --> ;0.0;0.0
EX_succ_e;b2976;;succ_e --> ;0.0;0.0
FBA;b2976;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b2976;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b2976;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b2976;;for_c --> for_e;0.0;0.0
FRD7;b2976;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b2976;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b2976;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b2976;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b2976;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b2976;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b2976;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b2976;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b2976;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b2976;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b2976;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b2976;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b2976;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b2976;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b2976;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b2976;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b2976;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b2976;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b2976;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b2976;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b2976;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b2976;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b2976;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b2976;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b2976;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b2976;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b2976;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b2976;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b2976;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b2976;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b2976;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b2976;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b2976;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b2976;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b2976;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b2976;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b2976;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b2976;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b2976;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b2976;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b2976;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b2976;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b2976;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b2976;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b2976;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b2976;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b2976;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b2976;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b2976;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b2976;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b2976;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b2976;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b3236;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;1.7902733216877847e-16
ACALDt;b3236;;acald_e <=> acald_c;0.0;0.0
ACKr;b3236;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b3236;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;8.339761944486769
ACONTb;b3236;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;8.33976194448677
ACt2r;b3236;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b3236;;amp_c + atp_c <=> 2.0 adp_c;0.0;3.674637143672371
AKGDH;b3236;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;7.448785511861677
AKGt2r;b3236;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b3236;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;-2.032533356393427e-17
ATPM;b3236;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b3236;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;49.26773551053178
Biomass_Ecoli_core;b3236;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8258192905969891
CO2t;b3236;;co2_e <=> co2_c;-22.809833310205086;-24.856847178999885
CS;b3236;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;8.339761944486769
CYTBD;b3236;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;47.80423499428138
D_LACt2;b3236;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b3236;;2pg_c <=> h2o_c + pep_c;14.716139568742859;16.569298921072935
ETOHt2r;b3236;;etoh_e + h_e <=> etoh_c + h_c;0.0;1.790273321687785e-16
EX_ac_e;b3236;;ac_e --> ;0.0;0.0
EX_acald_e;b3236;;acald_e --> ;0.0;0.0
EX_akg_e;b3236;;akg_e --> ;0.0;0.0
EX_co2_e;b3236;;co2_e <=> ;22.809833310205086;24.856847178999885
EX_etoh_e;b3236;;etoh_e --> ;0.0;0.0
EX_for_e;b3236;;for_e --> ;0.0;0.0
EX_fru_e;b3236;;fru_e --> ;0.0;0.0
EX_fum_e;b3236;;fum_e --> ;0.0;0.0
EX_glc__D_e;b3236;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b3236;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b3236;;glu__L_e --> ;0.0;0.0
EX_h_e;b3236;;h_e <=> ;17.530865429786523;16.565934969375554
EX_h2o_e;b3236;;h2o_e <=> ;29.175827135565836;30.872445219424566
EX_lac__D_e;b3236;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b3236;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b3236;;nh4_e <=> ;-4.765319193197444;-4.503027427767261
EX_o2_e;b3236;;o2_e <=> ;-21.799492655998886;-23.902117497140686
EX_pi_e;b3236;;pi_e <=> ;-3.214895047684769;-3.0379414243191736
EX_pyr_e;b3236;;pyr_e --> ;0.0;0.0
EX_succ_e;b3236;;succ_e --> ;0.0;0.0
FBA;b3236;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;9.178557551643177
FBP;b3236;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b3236;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b3236;;for_c --> for_e;0.0;0.0
FRD7;b3236;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b3236;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b3236;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;7.448785511861678
FUMt2_2;b3236;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b3236;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;0.0
GAPD;b3236;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;17.804724579806027
GLCpts;b3236;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b3236;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.21116199260565008
GLNabc;b3236;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b3236;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.291865435161611
GLUN;b3236;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b3236;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b3236;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b3236;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;0.0
H2Ot;b3236;;h2o_e <=> h2o_c;-29.175827135565836;-30.872445219424566
ICDHyr;b3236;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;8.33976194448677
ICL;b3236;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b3236;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b3236;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b3236;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b3236;;mal__L_c + nad_c --> h_c + nadh_c + oaa_c;5.064375661482158;0.0
ME1;b3236;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.7379908852183181
ME2;b3236;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;6.710794626643363
NADH16;b3236;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;40.355449482419694
NADTRHD;b3236;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b3236;;nh4_e <=> nh4_c;4.765319193197444;4.503027427767261
O2t;b3236;;o2_e <=> o2_c;21.799492655998886;23.902117497140686
PDH;b3236;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;11.43476748178616
PFK;b3236;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;9.178557551643177
PFL;b3236;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b3236;;g6p_c <=> f6p_c;4.860861146496871;9.83070704542762
PGK;b3236;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-17.80472457980603
PGL;b3236;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;0.0
PGM;b3236;;2pg_c <=> 3pg_c;-14.716139568742859;-16.569298921072935
PIt2r;b3236;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.0379414243191736
PPC;b3236;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;9.8152532709964
PPCK;b3236;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b3236;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;3.6746371436723706
PTAr;b3236;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b3236;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;0.0
PYRt2;b3236;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b3236;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;-0.5935989060811157
RPI;b3236;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-0.5935989060811155
SUCCt2_2;b3236;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b3236;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b3236;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;7.44878551186168
SUCOAS;b3236;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-7.4487855118616775
TALA;b3236;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;-0.14773907108780132
THD2;b3236;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b3236;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;-0.1477390710878013
TKT2;b3236;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;-0.44585983499331433
TPI;b3236;;dhap_c <=> g3p_c;7.477381962160304;9.178557551643177
ACALD;b1479;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b1479;;acald_e <=> acald_c;0.0;0.0
ACKr;b1479;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b1479;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.0072495753503325
ACONTb;b1479;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.0072495753503325
ACt2r;b1479;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b1479;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b1479;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482096
AKGt2r;b1479;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b1479;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b1479;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b1479;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b1479;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684306
CO2t;b1479;;co2_e <=> co2_c;-22.809833310205086;-22.809833310204976
CS;b1479;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350332
CYTBD;b1479;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.598985311997545
D_LACt2;b1479;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b1479;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.71613956874283
ETOHt2r;b1479;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b1479;;ac_e --> ;0.0;0.0
EX_acald_e;b1479;;acald_e --> ;0.0;0.0
EX_akg_e;b1479;;akg_e --> ;0.0;0.0
EX_co2_e;b1479;;co2_e <=> ;22.809833310205086;22.809833310204976
EX_etoh_e;b1479;;etoh_e --> ;0.0;0.0
EX_for_e;b1479;;for_e --> ;0.0;0.0
EX_fru_e;b1479;;fru_e --> ;0.0;0.0
EX_fum_e;b1479;;fum_e --> ;0.0;0.0
EX_glc__D_e;b1479;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b1479;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b1479;;glu__L_e --> ;0.0;0.0
EX_h_e;b1479;;h_e <=> ;17.530865429786523;17.530865429786726
EX_h2o_e;b1479;;h2o_e <=> ;29.175827135565836;29.175827135565825
EX_lac__D_e;b1479;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b1479;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b1479;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b1479;;o2_e <=> ;-21.799492655998886;-21.79949265599877
EX_pi_e;b1479;;pi_e <=> ;-3.214895047684769;-3.214895047684781
EX_pyr_e;b1479;;pyr_e --> ;0.0;0.0
EX_succ_e;b1479;;succ_e --> ;0.0;0.0
FBA;b1479;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160283
FBP;b1479;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b1479;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b1479;;for_c --> for_e;0.0;0.0
FRD7;b1479;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b1479;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b1479;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482097
FUMt2_2;b1479;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b1479;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.95998494457466
GAPD;b1479;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167604
GLCpts;b1479;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b1479;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182767
GLNabc;b1479;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b1479;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b1479;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b1479;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b1479;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b1479;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.959984944574659
H2Ot;b1479;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565825
ICDHyr;b1479;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350333
ICL;b1479;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b1479;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b1479;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b1479;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b1479;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.0643756614820985
ME1;b1479;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b1479;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b1479;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.53460965051544
NADTRHD;b1479;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b1479;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b1479;;o2_e <=> o2_c;21.799492655998886;21.79949265599877
PDH;b1479;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.282532599166617
PFK;b1479;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160284
PFL;b1479;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b1479;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496814
PGK;b1479;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.023526143167608
PGL;b1479;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574659
PGM;b1479;;2pg_c <=> 3pg_c;-14.716139568742859;-14.71613956874283
PIt2r;b1479;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684781
PPC;b1479;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687285
PPCK;b1479;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b1479;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b1479;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b1479;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067852
PYRt2;b1479;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b1479;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.6784818505075303
RPI;b1479;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.281503094067129
SUCCt2_2;b1479;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b1479;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b1479;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482097
SUCOAS;b1479;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482097
TALA;b1479;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615672
THD2;b1479;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b1479;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.496983757261567
TKT2;b1479;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245964
TPI;b1479;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160283
ACALD;b2463;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b2463;;acald_e <=> acald_c;0.0;0.0
ACKr;b2463;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b2463;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b2463;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b2463;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b2463;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b2463;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b2463;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b2463;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b2463;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b2463;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b2463;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b2463;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b2463;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b2463;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b2463;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b2463;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b2463;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b2463;;ac_e --> ;0.0;0.0
EX_acald_e;b2463;;acald_e --> ;0.0;0.0
EX_akg_e;b2463;;akg_e --> ;0.0;0.0
EX_co2_e;b2463;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b2463;;etoh_e --> ;0.0;0.0
EX_for_e;b2463;;for_e --> ;0.0;0.0
EX_fru_e;b2463;;fru_e --> ;0.0;0.0
EX_fum_e;b2463;;fum_e --> ;0.0;0.0
EX_glc__D_e;b2463;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b2463;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b2463;;glu__L_e --> ;0.0;0.0
EX_h_e;b2463;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b2463;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b2463;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b2463;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b2463;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b2463;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b2463;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b2463;;pyr_e --> ;0.0;0.0
EX_succ_e;b2463;;succ_e --> ;0.0;0.0
FBA;b2463;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b2463;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b2463;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b2463;;for_c --> for_e;0.0;0.0
FRD7;b2463;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b2463;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b2463;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b2463;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b2463;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b2463;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b2463;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b2463;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b2463;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b2463;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b2463;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b2463;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b2463;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b2463;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b2463;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b2463;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b2463;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b2463;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b2463;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b2463;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b2463;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b2463;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b2463;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b2463;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b2463;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b2463;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b2463;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b2463;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b2463;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b2463;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b2463;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b2463;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b2463;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b2463;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b2463;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b2463;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b2463;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b2463;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b2463;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b2463;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b2463;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b2463;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b2463;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b2463;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b2463;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b2463;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b2463;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b2463;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b2463;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b2463;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b2463;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b2463;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b2286;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;-8.279455380486583
ACALDt;b2286;;acald_e <=> acald_c;0.0;0.0
ACKr;b2286;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;-8.503585277961317
ACONTa;b2286;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;0.22836315646943348
ACONTb;b2286;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;0.2283631564694335
ACt2r;b2286;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;-8.503585277961317
ADK1;b2286;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b2286;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0
AKGt2r;b2286;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b2286;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;-8.279455380486583
ATPM;b2286;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b2286;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;-5.452052576810925
Biomass_Ecoli_core;b2286;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.21166294973530966
CO2t;b2286;;co2_e <=> co2_c;-22.809833310205086;0.37817819229208954
CS;b2286;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;0.22836315646943345
CYTBD;b2286;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;-3.545079361619323e-15
D_LACt2;b2286;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b2286;;2pg_c <=> h2o_c + pep_c;14.716139568742859;19.120688607914612
ETOHt2r;b2286;;etoh_e + h_e <=> etoh_c + h_c;0.0;-8.279455380486583
EX_ac_e;b2286;;ac_e --> ;0.0;8.503585277961317
EX_acald_e;b2286;;acald_e --> ;0.0;0.0
EX_akg_e;b2286;;akg_e --> ;0.0;0.0
EX_co2_e;b2286;;co2_e <=> ;22.809833310205086;-0.37817819229208954
EX_etoh_e;b2286;;etoh_e --> ;0.0;8.279455380486583
EX_for_e;b2286;;for_e --> ;0.0;17.80467421793533
EX_fru_e;b2286;;fru_e --> ;0.0;0.0
EX_fum_e;b2286;;fum_e --> ;0.0;0.0
EX_glc__D_e;b2286;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b2286;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b2286;;glu__L_e --> ;0.0;0.0
EX_h_e;b2286;;h_e <=> ;17.530865429786523;30.55421826758705
EX_h2o_e;b2286;;h2o_e <=> ;29.175827135565836;-7.115795981726764
EX_lac__D_e;b2286;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b2286;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b2286;;nh4_e <=> ;-4.765319193197444;-1.1541557323166962
EX_o2_e;b2286;;o2_e <=> ;-21.799492655998886;4.335920479686503e-15
EX_pi_e;b2286;;pi_e <=> ;-3.214895047684769;-0.7786444931913017
EX_pyr_e;b2286;;pyr_e --> ;0.0;0.0
EX_succ_e;b2286;;succ_e --> ;0.0;0.0
FBA;b2286;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;9.789458863898297
FBP;b2286;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b2286;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b2286;;for_c --> for_e;0.0;17.80467421793533
FRD7;b2286;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b2286;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b2286;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;-5.4142647879431474e-15
FUMt2_2;b2286;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b2286;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;0.0
GAPD;b2286;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;19.437336380718637
GLCpts;b2286;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b2286;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.054122216247318666
GLNabc;b2286;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b2286;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-1.1000335160693777
GLUN;b2286;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b2286;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b2286;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b2286;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;0.0
H2Ot;b2286;;h2o_e <=> h2o_c;-29.175827135565836;7.115795981726809
ICDHyr;b2286;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.22836315646943348
ICL;b2286;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b2286;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b2286;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b2286;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b2286;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;-4.961305216395132e-16
ME1;b2286;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b2286;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b2286;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;0.0
NADTRHD;b2286;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b2286;;nh4_e <=> nh4_c;4.765319193197444;1.1541557323166962
O2t;b2286;;o2_e <=> o2_c;21.799492655998886;-1.7817144499861175e-15
PDH;b2286;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;0.0
PFK;b2286;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;9.789458863898297
PFL;b2286;;coa_c + pyr_c --> accoa_c + for_c;0.0;17.804674217935325
PGI;b2286;;g6p_c <=> f6p_c;4.860861146496871;9.956609095304263
PGK;b2286;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-19.437336380718637
PGL;b2286;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;0.0
PGM;b2286;;2pg_c <=> 3pg_c;-14.716139568742859;-19.120688607914612
PIt2r;b2286;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;0.7786444931913017
PPC;b2286;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;0.6065413487615037
PPCK;b2286;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b2286;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b2286;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;8.503585277961317
PYK;b2286;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;8.404273021945505
PYRt2;b2286;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b2286;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;-0.15214332826974167
RPI;b2286;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-0.15214332826974164
SUCCt2_2;b2286;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b2286;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b2286;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;-3.545079361619323e-15
SUCOAS;b2286;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;4.550053240415208e-15
TALA;b2286;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;-0.037866501707647236
THD2;b2286;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;3.629194102456621
TKT1;b2286;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;-0.03786650170764723
TKT2;b2286;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;-0.11427682656209441
TPI;b2286;;dhap_c <=> g3p_c;7.477381962160304;9.789458863898297
ACALD;b2279;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;-8.27945538048658
ACALDt;b2279;;acald_e <=> acald_c;0.0;0.0
ACKr;b2279;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;-8.503585277961305
ACONTa;b2279;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;0.22836315646942648
ACONTb;b2279;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;0.2283631564694265
ACt2r;b2279;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;-8.503585277961305
ADK1;b2279;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b2279;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0
AKGt2r;b2279;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b2279;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;-8.27945538048658
ATPM;b2279;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b2279;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;-5.452052576810906
Biomass_Ecoli_core;b2279;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.21166294973531088
CO2t;b2279;;co2_e <=> co2_c;-22.809833310205086;0.37817819229207944
CS;b2279;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;0.22836315646942645
CYTBD;b2279;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;0.0
D_LACt2;b2279;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b2279;;2pg_c <=> h2o_c + pep_c;14.716139568742859;19.1206886079146
ETOHt2r;b2279;;etoh_e + h_e <=> etoh_c + h_c;0.0;-8.27945538048658
EX_ac_e;b2279;;ac_e --> ;0.0;8.503585277961305
EX_acald_e;b2279;;acald_e --> ;0.0;0.0
EX_akg_e;b2279;;akg_e --> ;0.0;0.0
EX_co2_e;b2279;;co2_e <=> ;22.809833310205086;-0.37817819229207944
EX_etoh_e;b2279;;etoh_e --> ;0.0;8.27945538048658
EX_for_e;b2279;;for_e --> ;0.0;17.804674217935307
EX_fru_e;b2279;;fru_e --> ;0.0;0.0
EX_fum_e;b2279;;fum_e --> ;0.0;0.0
EX_glc__D_e;b2279;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b2279;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b2279;;glu__L_e --> ;0.0;0.0
EX_h_e;b2279;;h_e <=> ;17.530865429786523;30.55421826758701
EX_h2o_e;b2279;;h2o_e <=> ;29.175827135565836;-7.115795981726792
EX_lac__D_e;b2279;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b2279;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b2279;;nh4_e <=> ;-4.765319193197444;-1.1541557323167029
EX_o2_e;b2279;;o2_e <=> ;-21.799492655998886;0.0
EX_pi_e;b2279;;pi_e <=> ;-3.214895047684769;-0.7786444931912647
EX_pyr_e;b2279;;pyr_e --> ;0.0;0.0
EX_succ_e;b2279;;succ_e --> ;0.0;0.0
FBA;b2279;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;9.789458863898288
FBP;b2279;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b2279;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b2279;;for_c --> for_e;0.0;17.804674217935307
FRD7;b2279;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b2279;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b2279;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;0.0
FUMt2_2;b2279;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b2279;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;0.0
GAPD;b2279;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;19.437336380718627
GLCpts;b2279;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b2279;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.054122216247318986
GLNabc;b2279;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b2279;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-1.100033516069384
GLUN;b2279;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b2279;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b2279;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b2279;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;0.0
H2Ot;b2279;;h2o_e <=> h2o_c;-29.175827135565836;7.115795981726792
ICDHyr;b2279;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.22836315646942648
ICL;b2279;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b2279;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b2279;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b2279;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b2279;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;0.0
ME1;b2279;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b2279;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b2279;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;0.0
NADTRHD;b2279;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b2279;;nh4_e <=> nh4_c;4.765319193197444;1.1541557323167029
O2t;b2279;;o2_e <=> o2_c;21.799492655998886;0.0
PDH;b2279;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;0.0
PFK;b2279;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;9.789458863898288
PFL;b2279;;coa_c + pyr_c --> accoa_c + for_c;0.0;17.804674217935307
PGI;b2279;;g6p_c <=> f6p_c;4.860861146496871;9.956609095304263
PGK;b2279;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-19.43733638071863
PGL;b2279;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;0.0
PGM;b2279;;2pg_c <=> 3pg_c;-14.716139568742859;-19.1206886079146
PIt2r;b2279;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;0.7786444931912647
PPC;b2279;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;0.6065413487615059
PPCK;b2279;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b2279;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b2279;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;8.503585277961305
PYK;b2279;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;8.404273021945494
PYRt2;b2279;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b2279;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;-0.1521433282697415
RPI;b2279;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-0.15214332826974147
SUCCt2_2;b2279;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b2279;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b2279;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;0.0
SUCOAS;b2279;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;0.0
TALA;b2279;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;-0.03786650170764712
THD2;b2279;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;3.6291941024566143
TKT1;b2279;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;-0.03786650170764712
TKT2;b2279;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;-0.11427682656209436
TPI;b2279;;dhap_c <=> g3p_c;7.477381962160304;9.789458863898288
ACALD;b2276;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;-8.27945538048658
ACALDt;b2276;;acald_e <=> acald_c;0.0;0.0
ACKr;b2276;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;-8.503585277961305
ACONTa;b2276;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;0.22836315646942648
ACONTb;b2276;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;0.2283631564694265
ACt2r;b2276;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;-8.503585277961305
ADK1;b2276;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b2276;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0
AKGt2r;b2276;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b2276;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;-8.27945538048658
ATPM;b2276;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b2276;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;-5.452052576810906
Biomass_Ecoli_core;b2276;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.21166294973531088
CO2t;b2276;;co2_e <=> co2_c;-22.809833310205086;0.37817819229207944
CS;b2276;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;0.22836315646942645
CYTBD;b2276;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;0.0
D_LACt2;b2276;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b2276;;2pg_c <=> h2o_c + pep_c;14.716139568742859;19.1206886079146
ETOHt2r;b2276;;etoh_e + h_e <=> etoh_c + h_c;0.0;-8.27945538048658
EX_ac_e;b2276;;ac_e --> ;0.0;8.503585277961305
EX_acald_e;b2276;;acald_e --> ;0.0;0.0
EX_akg_e;b2276;;akg_e --> ;0.0;0.0
EX_co2_e;b2276;;co2_e <=> ;22.809833310205086;-0.37817819229207944
EX_etoh_e;b2276;;etoh_e --> ;0.0;8.27945538048658
EX_for_e;b2276;;for_e --> ;0.0;17.804674217935307
EX_fru_e;b2276;;fru_e --> ;0.0;0.0
EX_fum_e;b2276;;fum_e --> ;0.0;0.0
EX_glc__D_e;b2276;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b2276;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b2276;;glu__L_e --> ;0.0;0.0
EX_h_e;b2276;;h_e <=> ;17.530865429786523;30.55421826758701
EX_h2o_e;b2276;;h2o_e <=> ;29.175827135565836;-7.115795981726792
EX_lac__D_e;b2276;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b2276;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b2276;;nh4_e <=> ;-4.765319193197444;-1.1541557323167029
EX_o2_e;b2276;;o2_e <=> ;-21.799492655998886;0.0
EX_pi_e;b2276;;pi_e <=> ;-3.214895047684769;-0.7786444931912647
EX_pyr_e;b2276;;pyr_e --> ;0.0;0.0
EX_succ_e;b2276;;succ_e --> ;0.0;0.0
FBA;b2276;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;9.789458863898288
FBP;b2276;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b2276;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b2276;;for_c --> for_e;0.0;17.804674217935307
FRD7;b2276;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b2276;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b2276;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;0.0
FUMt2_2;b2276;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b2276;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;0.0
GAPD;b2276;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;19.437336380718627
GLCpts;b2276;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b2276;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.054122216247318986
GLNabc;b2276;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b2276;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-1.100033516069384
GLUN;b2276;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b2276;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b2276;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b2276;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;0.0
H2Ot;b2276;;h2o_e <=> h2o_c;-29.175827135565836;7.115795981726792
ICDHyr;b2276;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.22836315646942648
ICL;b2276;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b2276;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b2276;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b2276;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b2276;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;0.0
ME1;b2276;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b2276;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b2276;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;0.0
NADTRHD;b2276;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b2276;;nh4_e <=> nh4_c;4.765319193197444;1.1541557323167029
O2t;b2276;;o2_e <=> o2_c;21.799492655998886;0.0
PDH;b2276;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;0.0
PFK;b2276;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;9.789458863898288
PFL;b2276;;coa_c + pyr_c --> accoa_c + for_c;0.0;17.804674217935307
PGI;b2276;;g6p_c <=> f6p_c;4.860861146496871;9.956609095304263
PGK;b2276;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-19.43733638071863
PGL;b2276;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;0.0
PGM;b2276;;2pg_c <=> 3pg_c;-14.716139568742859;-19.1206886079146
PIt2r;b2276;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;0.7786444931912647
PPC;b2276;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;0.6065413487615059
PPCK;b2276;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b2276;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b2276;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;8.503585277961305
PYK;b2276;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;8.404273021945494
PYRt2;b2276;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b2276;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;-0.1521433282697415
RPI;b2276;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-0.15214332826974147
SUCCt2_2;b2276;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b2276;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b2276;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;0.0
SUCOAS;b2276;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;0.0
TALA;b2276;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;-0.03786650170764712
THD2;b2276;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;3.6291941024566143
TKT1;b2276;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;-0.03786650170764712
TKT2;b2276;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;-0.11427682656209436
TPI;b2276;;dhap_c <=> g3p_c;7.477381962160304;9.789458863898288
ACALD;b2280;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;-8.27945538048658
ACALDt;b2280;;acald_e <=> acald_c;0.0;0.0
ACKr;b2280;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;-8.503585277961305
ACONTa;b2280;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;0.22836315646942648
ACONTb;b2280;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;0.2283631564694265
ACt2r;b2280;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;-8.503585277961305
ADK1;b2280;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b2280;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0
AKGt2r;b2280;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b2280;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;-8.27945538048658
ATPM;b2280;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b2280;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;-5.452052576810906
Biomass_Ecoli_core;b2280;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.21166294973531088
CO2t;b2280;;co2_e <=> co2_c;-22.809833310205086;0.37817819229207944
CS;b2280;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;0.22836315646942645
CYTBD;b2280;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;0.0
D_LACt2;b2280;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b2280;;2pg_c <=> h2o_c + pep_c;14.716139568742859;19.1206886079146
ETOHt2r;b2280;;etoh_e + h_e <=> etoh_c + h_c;0.0;-8.27945538048658
EX_ac_e;b2280;;ac_e --> ;0.0;8.503585277961305
EX_acald_e;b2280;;acald_e --> ;0.0;0.0
EX_akg_e;b2280;;akg_e --> ;0.0;0.0
EX_co2_e;b2280;;co2_e <=> ;22.809833310205086;-0.37817819229207944
EX_etoh_e;b2280;;etoh_e --> ;0.0;8.27945538048658
EX_for_e;b2280;;for_e --> ;0.0;17.804674217935307
EX_fru_e;b2280;;fru_e --> ;0.0;0.0
EX_fum_e;b2280;;fum_e --> ;0.0;0.0
EX_glc__D_e;b2280;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b2280;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b2280;;glu__L_e --> ;0.0;0.0
EX_h_e;b2280;;h_e <=> ;17.530865429786523;30.55421826758701
EX_h2o_e;b2280;;h2o_e <=> ;29.175827135565836;-7.115795981726792
EX_lac__D_e;b2280;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b2280;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b2280;;nh4_e <=> ;-4.765319193197444;-1.1541557323167029
EX_o2_e;b2280;;o2_e <=> ;-21.799492655998886;0.0
EX_pi_e;b2280;;pi_e <=> ;-3.214895047684769;-0.7786444931912647
EX_pyr_e;b2280;;pyr_e --> ;0.0;0.0
EX_succ_e;b2280;;succ_e --> ;0.0;0.0
FBA;b2280;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;9.789458863898288
FBP;b2280;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b2280;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b2280;;for_c --> for_e;0.0;17.804674217935307
FRD7;b2280;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b2280;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b2280;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;0.0
FUMt2_2;b2280;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b2280;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;0.0
GAPD;b2280;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;19.437336380718627
GLCpts;b2280;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b2280;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.054122216247318986
GLNabc;b2280;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b2280;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-1.100033516069384
GLUN;b2280;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b2280;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b2280;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b2280;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;0.0
H2Ot;b2280;;h2o_e <=> h2o_c;-29.175827135565836;7.115795981726792
ICDHyr;b2280;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.22836315646942648
ICL;b2280;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b2280;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b2280;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b2280;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b2280;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;0.0
ME1;b2280;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b2280;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b2280;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;0.0
NADTRHD;b2280;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b2280;;nh4_e <=> nh4_c;4.765319193197444;1.1541557323167029
O2t;b2280;;o2_e <=> o2_c;21.799492655998886;0.0
PDH;b2280;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;0.0
PFK;b2280;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;9.789458863898288
PFL;b2280;;coa_c + pyr_c --> accoa_c + for_c;0.0;17.804674217935307
PGI;b2280;;g6p_c <=> f6p_c;4.860861146496871;9.956609095304263
PGK;b2280;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-19.43733638071863
PGL;b2280;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;0.0
PGM;b2280;;2pg_c <=> 3pg_c;-14.716139568742859;-19.1206886079146
PIt2r;b2280;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;0.7786444931912647
PPC;b2280;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;0.6065413487615059
PPCK;b2280;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b2280;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b2280;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;8.503585277961305
PYK;b2280;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;8.404273021945494
PYRt2;b2280;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b2280;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;-0.1521433282697415
RPI;b2280;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-0.15214332826974147
SUCCt2_2;b2280;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b2280;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b2280;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;0.0
SUCOAS;b2280;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;0.0
TALA;b2280;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;-0.03786650170764712
THD2;b2280;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;3.6291941024566143
TKT1;b2280;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;-0.03786650170764712
TKT2;b2280;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;-0.11427682656209436
TPI;b2280;;dhap_c <=> g3p_c;7.477381962160304;9.789458863898288
ACALD;b2288;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;-8.27945538048658
ACALDt;b2288;;acald_e <=> acald_c;0.0;0.0
ACKr;b2288;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;-8.503585277961305
ACONTa;b2288;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;0.22836315646942648
ACONTb;b2288;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;0.2283631564694265
ACt2r;b2288;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;-8.503585277961305
ADK1;b2288;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b2288;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0
AKGt2r;b2288;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b2288;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;-8.27945538048658
ATPM;b2288;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b2288;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;-5.452052576810906
Biomass_Ecoli_core;b2288;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.21166294973531088
CO2t;b2288;;co2_e <=> co2_c;-22.809833310205086;0.37817819229207944
CS;b2288;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;0.22836315646942645
CYTBD;b2288;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;0.0
D_LACt2;b2288;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b2288;;2pg_c <=> h2o_c + pep_c;14.716139568742859;19.1206886079146
ETOHt2r;b2288;;etoh_e + h_e <=> etoh_c + h_c;0.0;-8.27945538048658
EX_ac_e;b2288;;ac_e --> ;0.0;8.503585277961305
EX_acald_e;b2288;;acald_e --> ;0.0;0.0
EX_akg_e;b2288;;akg_e --> ;0.0;0.0
EX_co2_e;b2288;;co2_e <=> ;22.809833310205086;-0.37817819229207944
EX_etoh_e;b2288;;etoh_e --> ;0.0;8.27945538048658
EX_for_e;b2288;;for_e --> ;0.0;17.804674217935307
EX_fru_e;b2288;;fru_e --> ;0.0;0.0
EX_fum_e;b2288;;fum_e --> ;0.0;0.0
EX_glc__D_e;b2288;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b2288;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b2288;;glu__L_e --> ;0.0;0.0
EX_h_e;b2288;;h_e <=> ;17.530865429786523;30.55421826758701
EX_h2o_e;b2288;;h2o_e <=> ;29.175827135565836;-7.115795981726792
EX_lac__D_e;b2288;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b2288;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b2288;;nh4_e <=> ;-4.765319193197444;-1.1541557323167029
EX_o2_e;b2288;;o2_e <=> ;-21.799492655998886;0.0
EX_pi_e;b2288;;pi_e <=> ;-3.214895047684769;-0.7786444931912647
EX_pyr_e;b2288;;pyr_e --> ;0.0;0.0
EX_succ_e;b2288;;succ_e --> ;0.0;0.0
FBA;b2288;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;9.789458863898288
FBP;b2288;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b2288;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b2288;;for_c --> for_e;0.0;17.804674217935307
FRD7;b2288;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b2288;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b2288;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;0.0
FUMt2_2;b2288;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b2288;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;0.0
GAPD;b2288;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;19.437336380718627
GLCpts;b2288;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b2288;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.054122216247318986
GLNabc;b2288;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b2288;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-1.100033516069384
GLUN;b2288;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b2288;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b2288;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b2288;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;0.0
H2Ot;b2288;;h2o_e <=> h2o_c;-29.175827135565836;7.115795981726792
ICDHyr;b2288;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.22836315646942648
ICL;b2288;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b2288;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b2288;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b2288;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b2288;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;0.0
ME1;b2288;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b2288;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b2288;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;0.0
NADTRHD;b2288;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b2288;;nh4_e <=> nh4_c;4.765319193197444;1.1541557323167029
O2t;b2288;;o2_e <=> o2_c;21.799492655998886;0.0
PDH;b2288;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;0.0
PFK;b2288;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;9.789458863898288
PFL;b2288;;coa_c + pyr_c --> accoa_c + for_c;0.0;17.804674217935307
PGI;b2288;;g6p_c <=> f6p_c;4.860861146496871;9.956609095304263
PGK;b2288;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-19.43733638071863
PGL;b2288;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;0.0
PGM;b2288;;2pg_c <=> 3pg_c;-14.716139568742859;-19.1206886079146
PIt2r;b2288;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;0.7786444931912647
PPC;b2288;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;0.6065413487615059
PPCK;b2288;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b2288;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b2288;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;8.503585277961305
PYK;b2288;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;8.404273021945494
PYRt2;b2288;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b2288;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;-0.1521433282697415
RPI;b2288;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-0.15214332826974147
SUCCt2_2;b2288;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b2288;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b2288;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;0.0
SUCOAS;b2288;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;0.0
TALA;b2288;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;-0.03786650170764712
THD2;b2288;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;3.6291941024566143
TKT1;b2288;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;-0.03786650170764712
TKT2;b2288;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;-0.11427682656209436
TPI;b2288;;dhap_c <=> g3p_c;7.477381962160304;9.789458863898288
ACALD;b2284;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;-8.27945538048658
ACALDt;b2284;;acald_e <=> acald_c;0.0;0.0
ACKr;b2284;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;-8.503585277961305
ACONTa;b2284;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;0.22836315646942648
ACONTb;b2284;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;0.2283631564694265
ACt2r;b2284;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;-8.503585277961305
ADK1;b2284;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b2284;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0
AKGt2r;b2284;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b2284;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;-8.27945538048658
ATPM;b2284;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b2284;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;-5.452052576810906
Biomass_Ecoli_core;b2284;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.21166294973531088
CO2t;b2284;;co2_e <=> co2_c;-22.809833310205086;0.37817819229207944
CS;b2284;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;0.22836315646942645
CYTBD;b2284;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;0.0
D_LACt2;b2284;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b2284;;2pg_c <=> h2o_c + pep_c;14.716139568742859;19.1206886079146
ETOHt2r;b2284;;etoh_e + h_e <=> etoh_c + h_c;0.0;-8.27945538048658
EX_ac_e;b2284;;ac_e --> ;0.0;8.503585277961305
EX_acald_e;b2284;;acald_e --> ;0.0;0.0
EX_akg_e;b2284;;akg_e --> ;0.0;0.0
EX_co2_e;b2284;;co2_e <=> ;22.809833310205086;-0.37817819229207944
EX_etoh_e;b2284;;etoh_e --> ;0.0;8.27945538048658
EX_for_e;b2284;;for_e --> ;0.0;17.804674217935307
EX_fru_e;b2284;;fru_e --> ;0.0;0.0
EX_fum_e;b2284;;fum_e --> ;0.0;0.0
EX_glc__D_e;b2284;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b2284;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b2284;;glu__L_e --> ;0.0;0.0
EX_h_e;b2284;;h_e <=> ;17.530865429786523;30.55421826758701
EX_h2o_e;b2284;;h2o_e <=> ;29.175827135565836;-7.115795981726792
EX_lac__D_e;b2284;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b2284;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b2284;;nh4_e <=> ;-4.765319193197444;-1.1541557323167029
EX_o2_e;b2284;;o2_e <=> ;-21.799492655998886;0.0
EX_pi_e;b2284;;pi_e <=> ;-3.214895047684769;-0.7786444931912647
EX_pyr_e;b2284;;pyr_e --> ;0.0;0.0
EX_succ_e;b2284;;succ_e --> ;0.0;0.0
FBA;b2284;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;9.789458863898288
FBP;b2284;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b2284;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b2284;;for_c --> for_e;0.0;17.804674217935307
FRD7;b2284;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b2284;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b2284;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;0.0
FUMt2_2;b2284;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b2284;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;0.0
GAPD;b2284;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;19.437336380718627
GLCpts;b2284;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b2284;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.054122216247318986
GLNabc;b2284;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b2284;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-1.100033516069384
GLUN;b2284;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b2284;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b2284;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b2284;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;0.0
H2Ot;b2284;;h2o_e <=> h2o_c;-29.175827135565836;7.115795981726792
ICDHyr;b2284;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.22836315646942648
ICL;b2284;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b2284;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b2284;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b2284;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b2284;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;0.0
ME1;b2284;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b2284;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b2284;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;0.0
NADTRHD;b2284;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b2284;;nh4_e <=> nh4_c;4.765319193197444;1.1541557323167029
O2t;b2284;;o2_e <=> o2_c;21.799492655998886;0.0
PDH;b2284;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;0.0
PFK;b2284;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;9.789458863898288
PFL;b2284;;coa_c + pyr_c --> accoa_c + for_c;0.0;17.804674217935307
PGI;b2284;;g6p_c <=> f6p_c;4.860861146496871;9.956609095304263
PGK;b2284;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-19.43733638071863
PGL;b2284;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;0.0
PGM;b2284;;2pg_c <=> 3pg_c;-14.716139568742859;-19.1206886079146
PIt2r;b2284;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;0.7786444931912647
PPC;b2284;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;0.6065413487615059
PPCK;b2284;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b2284;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b2284;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;8.503585277961305
PYK;b2284;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;8.404273021945494
PYRt2;b2284;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b2284;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;-0.1521433282697415
RPI;b2284;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-0.15214332826974147
SUCCt2_2;b2284;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b2284;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b2284;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;0.0
SUCOAS;b2284;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;0.0
TALA;b2284;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;-0.03786650170764712
THD2;b2284;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;3.6291941024566143
TKT1;b2284;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;-0.03786650170764712
TKT2;b2284;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;-0.11427682656209436
TPI;b2284;;dhap_c <=> g3p_c;7.477381962160304;9.789458863898288
ACALD;b2287;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;-8.27945538048658
ACALDt;b2287;;acald_e <=> acald_c;0.0;0.0
ACKr;b2287;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;-8.503585277961305
ACONTa;b2287;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;0.22836315646942648
ACONTb;b2287;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;0.2283631564694265
ACt2r;b2287;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;-8.503585277961305
ADK1;b2287;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b2287;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0
AKGt2r;b2287;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b2287;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;-8.27945538048658
ATPM;b2287;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b2287;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;-5.452052576810906
Biomass_Ecoli_core;b2287;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.21166294973531088
CO2t;b2287;;co2_e <=> co2_c;-22.809833310205086;0.37817819229207944
CS;b2287;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;0.22836315646942645
CYTBD;b2287;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;0.0
D_LACt2;b2287;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b2287;;2pg_c <=> h2o_c + pep_c;14.716139568742859;19.1206886079146
ETOHt2r;b2287;;etoh_e + h_e <=> etoh_c + h_c;0.0;-8.27945538048658
EX_ac_e;b2287;;ac_e --> ;0.0;8.503585277961305
EX_acald_e;b2287;;acald_e --> ;0.0;0.0
EX_akg_e;b2287;;akg_e --> ;0.0;0.0
EX_co2_e;b2287;;co2_e <=> ;22.809833310205086;-0.37817819229207944
EX_etoh_e;b2287;;etoh_e --> ;0.0;8.27945538048658
EX_for_e;b2287;;for_e --> ;0.0;17.804674217935307
EX_fru_e;b2287;;fru_e --> ;0.0;0.0
EX_fum_e;b2287;;fum_e --> ;0.0;0.0
EX_glc__D_e;b2287;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b2287;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b2287;;glu__L_e --> ;0.0;0.0
EX_h_e;b2287;;h_e <=> ;17.530865429786523;30.55421826758701
EX_h2o_e;b2287;;h2o_e <=> ;29.175827135565836;-7.115795981726792
EX_lac__D_e;b2287;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b2287;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b2287;;nh4_e <=> ;-4.765319193197444;-1.1541557323167029
EX_o2_e;b2287;;o2_e <=> ;-21.799492655998886;0.0
EX_pi_e;b2287;;pi_e <=> ;-3.214895047684769;-0.7786444931912647
EX_pyr_e;b2287;;pyr_e --> ;0.0;0.0
EX_succ_e;b2287;;succ_e --> ;0.0;0.0
FBA;b2287;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;9.789458863898288
FBP;b2287;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b2287;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b2287;;for_c --> for_e;0.0;17.804674217935307
FRD7;b2287;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b2287;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b2287;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;0.0
FUMt2_2;b2287;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b2287;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;0.0
GAPD;b2287;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;19.437336380718627
GLCpts;b2287;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b2287;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.054122216247318986
GLNabc;b2287;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b2287;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-1.100033516069384
GLUN;b2287;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b2287;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b2287;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b2287;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;0.0
H2Ot;b2287;;h2o_e <=> h2o_c;-29.175827135565836;7.115795981726792
ICDHyr;b2287;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.22836315646942648
ICL;b2287;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b2287;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b2287;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b2287;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b2287;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;0.0
ME1;b2287;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b2287;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b2287;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;0.0
NADTRHD;b2287;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b2287;;nh4_e <=> nh4_c;4.765319193197444;1.1541557323167029
O2t;b2287;;o2_e <=> o2_c;21.799492655998886;0.0
PDH;b2287;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;0.0
PFK;b2287;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;9.789458863898288
PFL;b2287;;coa_c + pyr_c --> accoa_c + for_c;0.0;17.804674217935307
PGI;b2287;;g6p_c <=> f6p_c;4.860861146496871;9.956609095304263
PGK;b2287;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-19.43733638071863
PGL;b2287;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;0.0
PGM;b2287;;2pg_c <=> 3pg_c;-14.716139568742859;-19.1206886079146
PIt2r;b2287;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;0.7786444931912647
PPC;b2287;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;0.6065413487615059
PPCK;b2287;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b2287;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b2287;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;8.503585277961305
PYK;b2287;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;8.404273021945494
PYRt2;b2287;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b2287;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;-0.1521433282697415
RPI;b2287;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-0.15214332826974147
SUCCt2_2;b2287;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b2287;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b2287;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;0.0
SUCOAS;b2287;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;0.0
TALA;b2287;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;-0.03786650170764712
THD2;b2287;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;3.6291941024566143
TKT1;b2287;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;-0.03786650170764712
TKT2;b2287;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;-0.11427682656209436
TPI;b2287;;dhap_c <=> g3p_c;7.477381962160304;9.789458863898288
ACALD;b2281;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;-8.27945538048658
ACALDt;b2281;;acald_e <=> acald_c;0.0;0.0
ACKr;b2281;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;-8.503585277961305
ACONTa;b2281;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;0.22836315646942648
ACONTb;b2281;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;0.2283631564694265
ACt2r;b2281;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;-8.503585277961305
ADK1;b2281;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b2281;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0
AKGt2r;b2281;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b2281;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;-8.27945538048658
ATPM;b2281;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b2281;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;-5.452052576810906
Biomass_Ecoli_core;b2281;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.21166294973531088
CO2t;b2281;;co2_e <=> co2_c;-22.809833310205086;0.37817819229207944
CS;b2281;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;0.22836315646942645
CYTBD;b2281;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;0.0
D_LACt2;b2281;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b2281;;2pg_c <=> h2o_c + pep_c;14.716139568742859;19.1206886079146
ETOHt2r;b2281;;etoh_e + h_e <=> etoh_c + h_c;0.0;-8.27945538048658
EX_ac_e;b2281;;ac_e --> ;0.0;8.503585277961305
EX_acald_e;b2281;;acald_e --> ;0.0;0.0
EX_akg_e;b2281;;akg_e --> ;0.0;0.0
EX_co2_e;b2281;;co2_e <=> ;22.809833310205086;-0.37817819229207944
EX_etoh_e;b2281;;etoh_e --> ;0.0;8.27945538048658
EX_for_e;b2281;;for_e --> ;0.0;17.804674217935307
EX_fru_e;b2281;;fru_e --> ;0.0;0.0
EX_fum_e;b2281;;fum_e --> ;0.0;0.0
EX_glc__D_e;b2281;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b2281;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b2281;;glu__L_e --> ;0.0;0.0
EX_h_e;b2281;;h_e <=> ;17.530865429786523;30.55421826758701
EX_h2o_e;b2281;;h2o_e <=> ;29.175827135565836;-7.115795981726792
EX_lac__D_e;b2281;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b2281;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b2281;;nh4_e <=> ;-4.765319193197444;-1.1541557323167029
EX_o2_e;b2281;;o2_e <=> ;-21.799492655998886;0.0
EX_pi_e;b2281;;pi_e <=> ;-3.214895047684769;-0.7786444931912647
EX_pyr_e;b2281;;pyr_e --> ;0.0;0.0
EX_succ_e;b2281;;succ_e --> ;0.0;0.0
FBA;b2281;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;9.789458863898288
FBP;b2281;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b2281;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b2281;;for_c --> for_e;0.0;17.804674217935307
FRD7;b2281;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b2281;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b2281;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;0.0
FUMt2_2;b2281;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b2281;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;0.0
GAPD;b2281;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;19.437336380718627
GLCpts;b2281;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b2281;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.054122216247318986
GLNabc;b2281;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b2281;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-1.100033516069384
GLUN;b2281;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b2281;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b2281;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b2281;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;0.0
H2Ot;b2281;;h2o_e <=> h2o_c;-29.175827135565836;7.115795981726792
ICDHyr;b2281;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.22836315646942648
ICL;b2281;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b2281;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b2281;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b2281;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b2281;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;0.0
ME1;b2281;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b2281;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b2281;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;0.0
NADTRHD;b2281;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b2281;;nh4_e <=> nh4_c;4.765319193197444;1.1541557323167029
O2t;b2281;;o2_e <=> o2_c;21.799492655998886;0.0
PDH;b2281;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;0.0
PFK;b2281;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;9.789458863898288
PFL;b2281;;coa_c + pyr_c --> accoa_c + for_c;0.0;17.804674217935307
PGI;b2281;;g6p_c <=> f6p_c;4.860861146496871;9.956609095304263
PGK;b2281;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-19.43733638071863
PGL;b2281;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;0.0
PGM;b2281;;2pg_c <=> 3pg_c;-14.716139568742859;-19.1206886079146
PIt2r;b2281;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;0.7786444931912647
PPC;b2281;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;0.6065413487615059
PPCK;b2281;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b2281;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b2281;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;8.503585277961305
PYK;b2281;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;8.404273021945494
PYRt2;b2281;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b2281;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;-0.1521433282697415
RPI;b2281;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-0.15214332826974147
SUCCt2_2;b2281;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b2281;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b2281;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;0.0
SUCOAS;b2281;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;0.0
TALA;b2281;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;-0.03786650170764712
THD2;b2281;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;3.6291941024566143
TKT1;b2281;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;-0.03786650170764712
TKT2;b2281;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;-0.11427682656209436
TPI;b2281;;dhap_c <=> g3p_c;7.477381962160304;9.789458863898288
ACALD;b2277;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;-8.27945538048658
ACALDt;b2277;;acald_e <=> acald_c;0.0;0.0
ACKr;b2277;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;-8.503585277961305
ACONTa;b2277;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;0.22836315646942648
ACONTb;b2277;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;0.2283631564694265
ACt2r;b2277;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;-8.503585277961305
ADK1;b2277;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b2277;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0
AKGt2r;b2277;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b2277;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;-8.27945538048658
ATPM;b2277;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b2277;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;-5.452052576810906
Biomass_Ecoli_core;b2277;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.21166294973531088
CO2t;b2277;;co2_e <=> co2_c;-22.809833310205086;0.37817819229207944
CS;b2277;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;0.22836315646942645
CYTBD;b2277;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;0.0
D_LACt2;b2277;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b2277;;2pg_c <=> h2o_c + pep_c;14.716139568742859;19.1206886079146
ETOHt2r;b2277;;etoh_e + h_e <=> etoh_c + h_c;0.0;-8.27945538048658
EX_ac_e;b2277;;ac_e --> ;0.0;8.503585277961305
EX_acald_e;b2277;;acald_e --> ;0.0;0.0
EX_akg_e;b2277;;akg_e --> ;0.0;0.0
EX_co2_e;b2277;;co2_e <=> ;22.809833310205086;-0.37817819229207944
EX_etoh_e;b2277;;etoh_e --> ;0.0;8.27945538048658
EX_for_e;b2277;;for_e --> ;0.0;17.804674217935307
EX_fru_e;b2277;;fru_e --> ;0.0;0.0
EX_fum_e;b2277;;fum_e --> ;0.0;0.0
EX_glc__D_e;b2277;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b2277;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b2277;;glu__L_e --> ;0.0;0.0
EX_h_e;b2277;;h_e <=> ;17.530865429786523;30.55421826758701
EX_h2o_e;b2277;;h2o_e <=> ;29.175827135565836;-7.115795981726792
EX_lac__D_e;b2277;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b2277;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b2277;;nh4_e <=> ;-4.765319193197444;-1.1541557323167029
EX_o2_e;b2277;;o2_e <=> ;-21.799492655998886;0.0
EX_pi_e;b2277;;pi_e <=> ;-3.214895047684769;-0.7786444931912647
EX_pyr_e;b2277;;pyr_e --> ;0.0;0.0
EX_succ_e;b2277;;succ_e --> ;0.0;0.0
FBA;b2277;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;9.789458863898288
FBP;b2277;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b2277;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b2277;;for_c --> for_e;0.0;17.804674217935307
FRD7;b2277;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b2277;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b2277;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;0.0
FUMt2_2;b2277;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b2277;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;0.0
GAPD;b2277;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;19.437336380718627
GLCpts;b2277;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b2277;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.054122216247318986
GLNabc;b2277;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b2277;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-1.100033516069384
GLUN;b2277;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b2277;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b2277;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b2277;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;0.0
H2Ot;b2277;;h2o_e <=> h2o_c;-29.175827135565836;7.115795981726792
ICDHyr;b2277;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.22836315646942648
ICL;b2277;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b2277;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b2277;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b2277;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b2277;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;0.0
ME1;b2277;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b2277;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b2277;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;0.0
NADTRHD;b2277;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b2277;;nh4_e <=> nh4_c;4.765319193197444;1.1541557323167029
O2t;b2277;;o2_e <=> o2_c;21.799492655998886;0.0
PDH;b2277;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;0.0
PFK;b2277;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;9.789458863898288
PFL;b2277;;coa_c + pyr_c --> accoa_c + for_c;0.0;17.804674217935307
PGI;b2277;;g6p_c <=> f6p_c;4.860861146496871;9.956609095304263
PGK;b2277;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-19.43733638071863
PGL;b2277;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;0.0
PGM;b2277;;2pg_c <=> 3pg_c;-14.716139568742859;-19.1206886079146
PIt2r;b2277;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;0.7786444931912647
PPC;b2277;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;0.6065413487615059
PPCK;b2277;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b2277;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b2277;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;8.503585277961305
PYK;b2277;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;8.404273021945494
PYRt2;b2277;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b2277;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;-0.1521433282697415
RPI;b2277;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-0.15214332826974147
SUCCt2_2;b2277;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b2277;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b2277;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;0.0
SUCOAS;b2277;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;0.0
TALA;b2277;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;-0.03786650170764712
THD2;b2277;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;3.6291941024566143
TKT1;b2277;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;-0.03786650170764712
TKT2;b2277;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;-0.11427682656209436
TPI;b2277;;dhap_c <=> g3p_c;7.477381962160304;9.789458863898288
ACALD;b2285;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;-8.27945538048658
ACALDt;b2285;;acald_e <=> acald_c;0.0;0.0
ACKr;b2285;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;-8.503585277961305
ACONTa;b2285;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;0.22836315646942648
ACONTb;b2285;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;0.2283631564694265
ACt2r;b2285;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;-8.503585277961305
ADK1;b2285;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b2285;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0
AKGt2r;b2285;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b2285;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;-8.27945538048658
ATPM;b2285;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b2285;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;-5.452052576810906
Biomass_Ecoli_core;b2285;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.21166294973531088
CO2t;b2285;;co2_e <=> co2_c;-22.809833310205086;0.37817819229207944
CS;b2285;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;0.22836315646942645
CYTBD;b2285;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;0.0
D_LACt2;b2285;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b2285;;2pg_c <=> h2o_c + pep_c;14.716139568742859;19.1206886079146
ETOHt2r;b2285;;etoh_e + h_e <=> etoh_c + h_c;0.0;-8.27945538048658
EX_ac_e;b2285;;ac_e --> ;0.0;8.503585277961305
EX_acald_e;b2285;;acald_e --> ;0.0;0.0
EX_akg_e;b2285;;akg_e --> ;0.0;0.0
EX_co2_e;b2285;;co2_e <=> ;22.809833310205086;-0.37817819229207944
EX_etoh_e;b2285;;etoh_e --> ;0.0;8.27945538048658
EX_for_e;b2285;;for_e --> ;0.0;17.804674217935307
EX_fru_e;b2285;;fru_e --> ;0.0;0.0
EX_fum_e;b2285;;fum_e --> ;0.0;0.0
EX_glc__D_e;b2285;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b2285;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b2285;;glu__L_e --> ;0.0;0.0
EX_h_e;b2285;;h_e <=> ;17.530865429786523;30.55421826758701
EX_h2o_e;b2285;;h2o_e <=> ;29.175827135565836;-7.115795981726792
EX_lac__D_e;b2285;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b2285;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b2285;;nh4_e <=> ;-4.765319193197444;-1.1541557323167029
EX_o2_e;b2285;;o2_e <=> ;-21.799492655998886;0.0
EX_pi_e;b2285;;pi_e <=> ;-3.214895047684769;-0.7786444931912647
EX_pyr_e;b2285;;pyr_e --> ;0.0;0.0
EX_succ_e;b2285;;succ_e --> ;0.0;0.0
FBA;b2285;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;9.789458863898288
FBP;b2285;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b2285;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b2285;;for_c --> for_e;0.0;17.804674217935307
FRD7;b2285;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b2285;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b2285;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;0.0
FUMt2_2;b2285;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b2285;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;0.0
GAPD;b2285;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;19.437336380718627
GLCpts;b2285;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b2285;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.054122216247318986
GLNabc;b2285;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b2285;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-1.100033516069384
GLUN;b2285;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b2285;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b2285;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b2285;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;0.0
H2Ot;b2285;;h2o_e <=> h2o_c;-29.175827135565836;7.115795981726792
ICDHyr;b2285;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.22836315646942648
ICL;b2285;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b2285;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b2285;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b2285;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b2285;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;0.0
ME1;b2285;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b2285;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b2285;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;0.0
NADTRHD;b2285;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b2285;;nh4_e <=> nh4_c;4.765319193197444;1.1541557323167029
O2t;b2285;;o2_e <=> o2_c;21.799492655998886;0.0
PDH;b2285;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;0.0
PFK;b2285;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;9.789458863898288
PFL;b2285;;coa_c + pyr_c --> accoa_c + for_c;0.0;17.804674217935307
PGI;b2285;;g6p_c <=> f6p_c;4.860861146496871;9.956609095304263
PGK;b2285;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-19.43733638071863
PGL;b2285;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;0.0
PGM;b2285;;2pg_c <=> 3pg_c;-14.716139568742859;-19.1206886079146
PIt2r;b2285;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;0.7786444931912647
PPC;b2285;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;0.6065413487615059
PPCK;b2285;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b2285;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b2285;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;8.503585277961305
PYK;b2285;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;8.404273021945494
PYRt2;b2285;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b2285;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;-0.1521433282697415
RPI;b2285;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-0.15214332826974147
SUCCt2_2;b2285;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b2285;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b2285;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;0.0
SUCOAS;b2285;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;0.0
TALA;b2285;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;-0.03786650170764712
THD2;b2285;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;3.6291941024566143
TKT1;b2285;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;-0.03786650170764712
TKT2;b2285;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;-0.11427682656209436
TPI;b2285;;dhap_c <=> g3p_c;7.477381962160304;9.789458863898288
ACALD;b2282;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;-8.27945538048658
ACALDt;b2282;;acald_e <=> acald_c;0.0;0.0
ACKr;b2282;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;-8.503585277961305
ACONTa;b2282;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;0.22836315646942648
ACONTb;b2282;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;0.2283631564694265
ACt2r;b2282;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;-8.503585277961305
ADK1;b2282;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b2282;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0
AKGt2r;b2282;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b2282;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;-8.27945538048658
ATPM;b2282;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b2282;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;-5.452052576810906
Biomass_Ecoli_core;b2282;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.21166294973531088
CO2t;b2282;;co2_e <=> co2_c;-22.809833310205086;0.37817819229207944
CS;b2282;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;0.22836315646942645
CYTBD;b2282;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;0.0
D_LACt2;b2282;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b2282;;2pg_c <=> h2o_c + pep_c;14.716139568742859;19.1206886079146
ETOHt2r;b2282;;etoh_e + h_e <=> etoh_c + h_c;0.0;-8.27945538048658
EX_ac_e;b2282;;ac_e --> ;0.0;8.503585277961305
EX_acald_e;b2282;;acald_e --> ;0.0;0.0
EX_akg_e;b2282;;akg_e --> ;0.0;0.0
EX_co2_e;b2282;;co2_e <=> ;22.809833310205086;-0.37817819229207944
EX_etoh_e;b2282;;etoh_e --> ;0.0;8.27945538048658
EX_for_e;b2282;;for_e --> ;0.0;17.804674217935307
EX_fru_e;b2282;;fru_e --> ;0.0;0.0
EX_fum_e;b2282;;fum_e --> ;0.0;0.0
EX_glc__D_e;b2282;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b2282;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b2282;;glu__L_e --> ;0.0;0.0
EX_h_e;b2282;;h_e <=> ;17.530865429786523;30.55421826758701
EX_h2o_e;b2282;;h2o_e <=> ;29.175827135565836;-7.115795981726792
EX_lac__D_e;b2282;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b2282;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b2282;;nh4_e <=> ;-4.765319193197444;-1.1541557323167029
EX_o2_e;b2282;;o2_e <=> ;-21.799492655998886;0.0
EX_pi_e;b2282;;pi_e <=> ;-3.214895047684769;-0.7786444931912647
EX_pyr_e;b2282;;pyr_e --> ;0.0;0.0
EX_succ_e;b2282;;succ_e --> ;0.0;0.0
FBA;b2282;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;9.789458863898288
FBP;b2282;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b2282;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b2282;;for_c --> for_e;0.0;17.804674217935307
FRD7;b2282;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b2282;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b2282;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;0.0
FUMt2_2;b2282;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b2282;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;0.0
GAPD;b2282;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;19.437336380718627
GLCpts;b2282;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b2282;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.054122216247318986
GLNabc;b2282;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b2282;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-1.100033516069384
GLUN;b2282;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b2282;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b2282;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b2282;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;0.0
H2Ot;b2282;;h2o_e <=> h2o_c;-29.175827135565836;7.115795981726792
ICDHyr;b2282;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.22836315646942648
ICL;b2282;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b2282;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b2282;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b2282;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b2282;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;0.0
ME1;b2282;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b2282;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b2282;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;0.0
NADTRHD;b2282;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b2282;;nh4_e <=> nh4_c;4.765319193197444;1.1541557323167029
O2t;b2282;;o2_e <=> o2_c;21.799492655998886;0.0
PDH;b2282;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;0.0
PFK;b2282;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;9.789458863898288
PFL;b2282;;coa_c + pyr_c --> accoa_c + for_c;0.0;17.804674217935307
PGI;b2282;;g6p_c <=> f6p_c;4.860861146496871;9.956609095304263
PGK;b2282;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-19.43733638071863
PGL;b2282;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;0.0
PGM;b2282;;2pg_c <=> 3pg_c;-14.716139568742859;-19.1206886079146
PIt2r;b2282;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;0.7786444931912647
PPC;b2282;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;0.6065413487615059
PPCK;b2282;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b2282;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b2282;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;8.503585277961305
PYK;b2282;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;8.404273021945494
PYRt2;b2282;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b2282;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;-0.1521433282697415
RPI;b2282;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-0.15214332826974147
SUCCt2_2;b2282;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b2282;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b2282;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;0.0
SUCOAS;b2282;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;0.0
TALA;b2282;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;-0.03786650170764712
THD2;b2282;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;3.6291941024566143
TKT1;b2282;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;-0.03786650170764712
TKT2;b2282;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;-0.11427682656209436
TPI;b2282;;dhap_c <=> g3p_c;7.477381962160304;9.789458863898288
ACALD;b2278;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;-8.27945538048658
ACALDt;b2278;;acald_e <=> acald_c;0.0;0.0
ACKr;b2278;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;-8.503585277961305
ACONTa;b2278;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;0.22836315646942648
ACONTb;b2278;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;0.2283631564694265
ACt2r;b2278;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;-8.503585277961305
ADK1;b2278;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b2278;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0
AKGt2r;b2278;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b2278;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;-8.27945538048658
ATPM;b2278;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b2278;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;-5.452052576810906
Biomass_Ecoli_core;b2278;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.21166294973531088
CO2t;b2278;;co2_e <=> co2_c;-22.809833310205086;0.37817819229207944
CS;b2278;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;0.22836315646942645
CYTBD;b2278;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;0.0
D_LACt2;b2278;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b2278;;2pg_c <=> h2o_c + pep_c;14.716139568742859;19.1206886079146
ETOHt2r;b2278;;etoh_e + h_e <=> etoh_c + h_c;0.0;-8.27945538048658
EX_ac_e;b2278;;ac_e --> ;0.0;8.503585277961305
EX_acald_e;b2278;;acald_e --> ;0.0;0.0
EX_akg_e;b2278;;akg_e --> ;0.0;0.0
EX_co2_e;b2278;;co2_e <=> ;22.809833310205086;-0.37817819229207944
EX_etoh_e;b2278;;etoh_e --> ;0.0;8.27945538048658
EX_for_e;b2278;;for_e --> ;0.0;17.804674217935307
EX_fru_e;b2278;;fru_e --> ;0.0;0.0
EX_fum_e;b2278;;fum_e --> ;0.0;0.0
EX_glc__D_e;b2278;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b2278;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b2278;;glu__L_e --> ;0.0;0.0
EX_h_e;b2278;;h_e <=> ;17.530865429786523;30.55421826758701
EX_h2o_e;b2278;;h2o_e <=> ;29.175827135565836;-7.115795981726792
EX_lac__D_e;b2278;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b2278;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b2278;;nh4_e <=> ;-4.765319193197444;-1.1541557323167029
EX_o2_e;b2278;;o2_e <=> ;-21.799492655998886;0.0
EX_pi_e;b2278;;pi_e <=> ;-3.214895047684769;-0.7786444931912647
EX_pyr_e;b2278;;pyr_e --> ;0.0;0.0
EX_succ_e;b2278;;succ_e --> ;0.0;0.0
FBA;b2278;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;9.789458863898288
FBP;b2278;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b2278;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b2278;;for_c --> for_e;0.0;17.804674217935307
FRD7;b2278;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b2278;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b2278;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;0.0
FUMt2_2;b2278;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b2278;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;0.0
GAPD;b2278;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;19.437336380718627
GLCpts;b2278;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b2278;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.054122216247318986
GLNabc;b2278;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b2278;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-1.100033516069384
GLUN;b2278;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b2278;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b2278;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b2278;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;0.0
H2Ot;b2278;;h2o_e <=> h2o_c;-29.175827135565836;7.115795981726792
ICDHyr;b2278;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.22836315646942648
ICL;b2278;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b2278;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b2278;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b2278;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b2278;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;0.0
ME1;b2278;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b2278;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b2278;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;0.0
NADTRHD;b2278;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b2278;;nh4_e <=> nh4_c;4.765319193197444;1.1541557323167029
O2t;b2278;;o2_e <=> o2_c;21.799492655998886;0.0
PDH;b2278;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;0.0
PFK;b2278;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;9.789458863898288
PFL;b2278;;coa_c + pyr_c --> accoa_c + for_c;0.0;17.804674217935307
PGI;b2278;;g6p_c <=> f6p_c;4.860861146496871;9.956609095304263
PGK;b2278;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-19.43733638071863
PGL;b2278;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;0.0
PGM;b2278;;2pg_c <=> 3pg_c;-14.716139568742859;-19.1206886079146
PIt2r;b2278;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;0.7786444931912647
PPC;b2278;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;0.6065413487615059
PPCK;b2278;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b2278;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b2278;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;8.503585277961305
PYK;b2278;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;8.404273021945494
PYRt2;b2278;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b2278;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;-0.1521433282697415
RPI;b2278;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-0.15214332826974147
SUCCt2_2;b2278;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b2278;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b2278;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;0.0
SUCOAS;b2278;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;0.0
TALA;b2278;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;-0.03786650170764712
THD2;b2278;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;3.6291941024566143
TKT1;b2278;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;-0.03786650170764712
TKT2;b2278;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;-0.11427682656209436
TPI;b2278;;dhap_c <=> g3p_c;7.477381962160304;9.789458863898288
ACALD;b2283;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;-8.27945538048658
ACALDt;b2283;;acald_e <=> acald_c;0.0;0.0
ACKr;b2283;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;-8.503585277961305
ACONTa;b2283;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;0.22836315646942648
ACONTb;b2283;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;0.2283631564694265
ACt2r;b2283;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;-8.503585277961305
ADK1;b2283;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b2283;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0
AKGt2r;b2283;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b2283;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;-8.27945538048658
ATPM;b2283;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b2283;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;-5.452052576810906
Biomass_Ecoli_core;b2283;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.21166294973531088
CO2t;b2283;;co2_e <=> co2_c;-22.809833310205086;0.37817819229207944
CS;b2283;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;0.22836315646942645
CYTBD;b2283;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;0.0
D_LACt2;b2283;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b2283;;2pg_c <=> h2o_c + pep_c;14.716139568742859;19.1206886079146
ETOHt2r;b2283;;etoh_e + h_e <=> etoh_c + h_c;0.0;-8.27945538048658
EX_ac_e;b2283;;ac_e --> ;0.0;8.503585277961305
EX_acald_e;b2283;;acald_e --> ;0.0;0.0
EX_akg_e;b2283;;akg_e --> ;0.0;0.0
EX_co2_e;b2283;;co2_e <=> ;22.809833310205086;-0.37817819229207944
EX_etoh_e;b2283;;etoh_e --> ;0.0;8.27945538048658
EX_for_e;b2283;;for_e --> ;0.0;17.804674217935307
EX_fru_e;b2283;;fru_e --> ;0.0;0.0
EX_fum_e;b2283;;fum_e --> ;0.0;0.0
EX_glc__D_e;b2283;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b2283;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b2283;;glu__L_e --> ;0.0;0.0
EX_h_e;b2283;;h_e <=> ;17.530865429786523;30.55421826758701
EX_h2o_e;b2283;;h2o_e <=> ;29.175827135565836;-7.115795981726792
EX_lac__D_e;b2283;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b2283;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b2283;;nh4_e <=> ;-4.765319193197444;-1.1541557323167029
EX_o2_e;b2283;;o2_e <=> ;-21.799492655998886;0.0
EX_pi_e;b2283;;pi_e <=> ;-3.214895047684769;-0.7786444931912647
EX_pyr_e;b2283;;pyr_e --> ;0.0;0.0
EX_succ_e;b2283;;succ_e --> ;0.0;0.0
FBA;b2283;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;9.789458863898288
FBP;b2283;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b2283;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b2283;;for_c --> for_e;0.0;17.804674217935307
FRD7;b2283;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b2283;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b2283;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;0.0
FUMt2_2;b2283;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b2283;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;0.0
GAPD;b2283;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;19.437336380718627
GLCpts;b2283;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b2283;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.054122216247318986
GLNabc;b2283;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b2283;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-1.100033516069384
GLUN;b2283;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b2283;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b2283;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b2283;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;0.0
H2Ot;b2283;;h2o_e <=> h2o_c;-29.175827135565836;7.115795981726792
ICDHyr;b2283;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.22836315646942648
ICL;b2283;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b2283;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b2283;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b2283;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b2283;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;0.0
ME1;b2283;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b2283;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b2283;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;0.0
NADTRHD;b2283;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b2283;;nh4_e <=> nh4_c;4.765319193197444;1.1541557323167029
O2t;b2283;;o2_e <=> o2_c;21.799492655998886;0.0
PDH;b2283;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;0.0
PFK;b2283;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;9.789458863898288
PFL;b2283;;coa_c + pyr_c --> accoa_c + for_c;0.0;17.804674217935307
PGI;b2283;;g6p_c <=> f6p_c;4.860861146496871;9.956609095304263
PGK;b2283;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-19.43733638071863
PGL;b2283;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;0.0
PGM;b2283;;2pg_c <=> 3pg_c;-14.716139568742859;-19.1206886079146
PIt2r;b2283;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;0.7786444931912647
PPC;b2283;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;0.6065413487615059
PPCK;b2283;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b2283;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b2283;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;8.503585277961305
PYK;b2283;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;8.404273021945494
PYRt2;b2283;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b2283;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;-0.1521433282697415
RPI;b2283;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-0.15214332826974147
SUCCt2_2;b2283;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b2283;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b2283;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;0.0
SUCOAS;b2283;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;0.0
TALA;b2283;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;-0.03786650170764712
THD2;b2283;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;3.6291941024566143
TKT1;b2283;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;-0.03786650170764712
TKT2;b2283;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;-0.11427682656209436
TPI;b2283;;dhap_c <=> g3p_c;7.477381962160304;9.789458863898288
ACALD;b3962;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b3962;;acald_e <=> acald_c;0.0;0.0
ACKr;b3962;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;8.660501956727496e-15
ACONTa;b3962;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.0072495753503325
ACONTb;b3962;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.0072495753503325
ACt2r;b3962;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b3962;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b3962;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482096
AKGt2r;b3962;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b3962;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b3962;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b3962;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.51400977451744
Biomass_Ecoli_core;b3962;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b3962;;co2_e <=> co2_c;-22.809833310205086;-22.809833310204965
CS;b3962;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.0072495753503325
CYTBD;b3962;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199752
D_LACt2;b3962;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b3962;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.71613956874283
ETOHt2r;b3962;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b3962;;ac_e --> ;0.0;0.0
EX_acald_e;b3962;;acald_e --> ;0.0;0.0
EX_akg_e;b3962;;akg_e --> ;0.0;0.0
EX_co2_e;b3962;;co2_e <=> ;22.809833310205086;22.809833310204965
EX_etoh_e;b3962;;etoh_e --> ;0.0;0.0
EX_for_e;b3962;;for_e --> ;0.0;0.0
EX_fru_e;b3962;;fru_e --> ;0.0;0.0
EX_fum_e;b3962;;fum_e --> ;0.0;0.0
EX_glc__D_e;b3962;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b3962;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b3962;;glu__L_e --> ;0.0;0.0
EX_h_e;b3962;;h_e <=> ;17.530865429786523;17.530865429786747
EX_h2o_e;b3962;;h2o_e <=> ;29.175827135565836;29.17582713556577
EX_lac__D_e;b3962;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b3962;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b3962;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b3962;;o2_e <=> ;-21.799492655998886;-21.799492655998755
EX_pi_e;b3962;;pi_e <=> ;-3.214895047684769;-3.2148950476847435
EX_pyr_e;b3962;;pyr_e --> ;0.0;0.0
EX_succ_e;b3962;;succ_e --> ;0.0;0.0
FBA;b3962;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.4773819621602815
FBP;b3962;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b3962;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b3962;;for_c --> for_e;0.0;0.0
FRD7;b3962;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b3962;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b3962;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482097
FUMt2_2;b3962;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b3962;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574662
GAPD;b3962;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167604
GLCpts;b3962;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b3962;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b3962;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b3962;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b3962;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b3962;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b3962;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b3962;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.959984944574661
H2Ot;b3962;;h2o_e <=> h2o_c;-29.175827135565836;-29.17582713556577
ICDHyr;b3962;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350333
ICL;b3962;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b3962;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b3962;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b3962;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b3962;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482096
ME1;b3962;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b3962;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b3962;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515414
NADTRHD;b3962;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b3962;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b3962;;o2_e <=> o2_c;21.799492655998886;21.799492655998755
PDH;b3962;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.282532599166615
PFK;b3962;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160282
PFL;b3962;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b3962;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496811
PGK;b3962;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.023526143167608
PGL;b3962;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.9599849445746615
PGM;b3962;;2pg_c <=> 3pg_c;-14.716139568742859;-14.71613956874283
PIt2r;b3962;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.2148950476847435
PPC;b3962;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687303
PPCK;b3962;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b3962;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b3962;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;-8.660501956727496e-15
PYK;b3962;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067872
PYRt2;b3962;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b3962;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507533
RPI;b3962;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.281503094067128
SUCCt2_2;b3962;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b3962;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b3962;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482097
SUCOAS;b3962;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482097
TALA;b3962;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.496983757261568
THD2;b3962;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b3962;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.496983757261568
TKT2;b3962;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.1814980932459642
TPI;b3962;;dhap_c <=> g3p_c;7.477381962160304;7.4773819621602815
ACALD;b1602;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b1602;;acald_e <=> acald_c;0.0;0.0
ACKr;b1602;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b1602;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b1602;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b1602;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b1602;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b1602;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b1602;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b1602;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b1602;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b1602;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b1602;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b1602;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b1602;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b1602;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b1602;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b1602;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b1602;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b1602;;ac_e --> ;0.0;0.0
EX_acald_e;b1602;;acald_e --> ;0.0;0.0
EX_akg_e;b1602;;akg_e --> ;0.0;0.0
EX_co2_e;b1602;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b1602;;etoh_e --> ;0.0;0.0
EX_for_e;b1602;;for_e --> ;0.0;0.0
EX_fru_e;b1602;;fru_e --> ;0.0;0.0
EX_fum_e;b1602;;fum_e --> ;0.0;0.0
EX_glc__D_e;b1602;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b1602;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b1602;;glu__L_e --> ;0.0;0.0
EX_h_e;b1602;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b1602;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b1602;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b1602;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b1602;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b1602;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b1602;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b1602;;pyr_e --> ;0.0;0.0
EX_succ_e;b1602;;succ_e --> ;0.0;0.0
FBA;b1602;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b1602;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b1602;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b1602;;for_c --> for_e;0.0;0.0
FRD7;b1602;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b1602;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b1602;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b1602;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b1602;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b1602;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b1602;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b1602;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b1602;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b1602;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b1602;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b1602;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b1602;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b1602;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b1602;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b1602;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b1602;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b1602;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b1602;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b1602;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b1602;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b1602;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b1602;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b1602;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b1602;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b1602;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b1602;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b1602;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b1602;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b1602;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b1602;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b1602;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b1602;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b1602;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b1602;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b1602;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b1602;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b1602;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b1602;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b1602;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b1602;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b1602;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b1602;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b1602;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b1602;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b1602;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b1602;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b1602;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b1602;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b1602;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b1602;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b1602;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b1603;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b1603;;acald_e <=> acald_c;0.0;0.0
ACKr;b1603;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b1603;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b1603;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b1603;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b1603;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b1603;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b1603;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b1603;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b1603;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b1603;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b1603;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b1603;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b1603;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b1603;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b1603;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b1603;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b1603;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b1603;;ac_e --> ;0.0;0.0
EX_acald_e;b1603;;acald_e --> ;0.0;0.0
EX_akg_e;b1603;;akg_e --> ;0.0;0.0
EX_co2_e;b1603;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b1603;;etoh_e --> ;0.0;0.0
EX_for_e;b1603;;for_e --> ;0.0;0.0
EX_fru_e;b1603;;fru_e --> ;0.0;0.0
EX_fum_e;b1603;;fum_e --> ;0.0;0.0
EX_glc__D_e;b1603;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b1603;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b1603;;glu__L_e --> ;0.0;0.0
EX_h_e;b1603;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b1603;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b1603;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b1603;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b1603;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b1603;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b1603;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b1603;;pyr_e --> ;0.0;0.0
EX_succ_e;b1603;;succ_e --> ;0.0;0.0
FBA;b1603;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b1603;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b1603;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b1603;;for_c --> for_e;0.0;0.0
FRD7;b1603;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b1603;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b1603;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b1603;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b1603;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b1603;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b1603;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b1603;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b1603;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b1603;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b1603;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b1603;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b1603;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b1603;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b1603;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b1603;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b1603;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b1603;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b1603;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b1603;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b1603;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b1603;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b1603;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b1603;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b1603;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b1603;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b1603;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b1603;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b1603;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b1603;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b1603;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b1603;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b1603;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b1603;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b1603;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b1603;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b1603;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b1603;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b1603;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b1603;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b1603;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b1603;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b1603;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b1603;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b1603;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b1603;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b1603;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b1603;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b1603;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b1603;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b1603;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b1603;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b0451;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b0451;;acald_e <=> acald_c;0.0;0.0
ACKr;b0451;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b0451;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b0451;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b0451;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b0451;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b0451;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b0451;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b0451;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b0451;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b0451;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b0451;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b0451;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b0451;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b0451;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b0451;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b0451;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b0451;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b0451;;ac_e --> ;0.0;0.0
EX_acald_e;b0451;;acald_e --> ;0.0;0.0
EX_akg_e;b0451;;akg_e --> ;0.0;0.0
EX_co2_e;b0451;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b0451;;etoh_e --> ;0.0;0.0
EX_for_e;b0451;;for_e --> ;0.0;0.0
EX_fru_e;b0451;;fru_e --> ;0.0;0.0
EX_fum_e;b0451;;fum_e --> ;0.0;0.0
EX_glc__D_e;b0451;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b0451;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b0451;;glu__L_e --> ;0.0;0.0
EX_h_e;b0451;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b0451;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b0451;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b0451;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b0451;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b0451;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b0451;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b0451;;pyr_e --> ;0.0;0.0
EX_succ_e;b0451;;succ_e --> ;0.0;0.0
FBA;b0451;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b0451;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b0451;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b0451;;for_c --> for_e;0.0;0.0
FRD7;b0451;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b0451;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b0451;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b0451;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b0451;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b0451;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b0451;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b0451;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b0451;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b0451;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b0451;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b0451;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b0451;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b0451;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b0451;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b0451;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b0451;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b0451;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b0451;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b0451;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b0451;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b0451;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b0451;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b0451;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b0451;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b0451;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b0451;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b0451;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b0451;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b0451;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b0451;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b0451;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b0451;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b0451;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b0451;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b0451;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b0451;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b0451;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b0451;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b0451;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b0451;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b0451;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b0451;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b0451;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b0451;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b0451;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b0451;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b0451;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b0451;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b0451;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b0451;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b0451;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b0114;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b0114;;acald_e <=> acald_c;0.0;0.0
ACKr;b0114;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b0114;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;4.757262793109044
ACONTb;b0114;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;4.757262793109045
ACt2r;b0114;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b0114;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b0114;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;3.897707559161589
AKGt2r;b0114;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b0114;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b0114;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b0114;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;43.67177423054358
Biomass_Ecoli_core;b0114;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.7966959254309572
CO2t;b0114;;co2_e <=> co2_c;-22.809833310205086;-18.353086762883773
CS;b0114;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;4.757262793109044
CYTBD;b0114;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;42.60717298942525
D_LACt2;b0114;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b0114;;2pg_c <=> h2o_c + pep_c;14.716139568742859;12.696576698806151
ETOHt2r;b0114;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b0114;;ac_e --> ;0.0;0.0
EX_acald_e;b0114;;acald_e --> ;0.0;0.0
EX_akg_e;b0114;;akg_e --> ;0.0;0.0
EX_co2_e;b0114;;co2_e <=> ;22.809833310205086;18.353086762883773
EX_etoh_e;b0114;;etoh_e --> ;0.0;0.0
EX_for_e;b0114;;for_e --> ;0.0;7.743119782439185
EX_fru_e;b0114;;fru_e --> ;0.0;0.0
EX_fum_e;b0114;;fum_e --> ;0.0;0.0
EX_glc__D_e;b0114;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b0114;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b0114;;glu__L_e --> ;0.0;0.0
EX_h_e;b0114;;h_e <=> ;17.530865429786523;23.72484004658422
EX_h2o_e;b0114;;h2o_e <=> ;29.175827135565836;24.156538562093008
EX_lac__D_e;b0114;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b0114;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b0114;;nh4_e <=> ;-4.765319193197444;-4.344223542189922
EX_o2_e;b0114;;o2_e <=> ;-21.799492655998886;-21.303586494712622
EX_pi_e;b0114;;pi_e <=> ;-3.214895047684769;-2.930805300882891
EX_pyr_e;b0114;;pyr_e --> ;0.0;0.0
EX_succ_e;b0114;;succ_e --> ;0.0;0.0
FBA;b0114;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;5.213817144797803
FBP;b0114;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b0114;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b0114;;for_c --> for_e;0.0;7.743119782439185
FRD7;b0114;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b0114;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b0114;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;3.8977075591615895
FUMt2_2;b0114;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b0114;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;11.98112825452808
GAPD;b0114;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;13.888433803250864
GLCpts;b0114;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b0114;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.2037151481326957
GLNabc;b0114;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b0114;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.140508394057227
GLUN;b0114;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b0114;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b0114;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b0114;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;11.981128254528079
H2Ot;b0114;;h2o_e <=> h2o_c;-29.175827135565836;-24.156538562093008
ICDHyr;b0114;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;4.757262793109044
ICL;b0114;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b0114;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b0114;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b0114;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b0114;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;3.8977075591615895
ME1;b0114;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b0114;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b0114;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.709465430263656
NADTRHD;b0114;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;14.199736061186005
NH4t;b0114;;nh4_e <=> nh4_c;4.765319193197444;4.344223542189923
O2t;b0114;;o2_e <=> o2_c;21.799492655998886;21.303586494712622
PDH;b0114;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;0.0
PFK;b0114;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;5.213817144797803
PFL;b0114;;coa_c + pyr_c --> accoa_c + for_c;0.0;7.743119782439184
PGI;b0114;;g6p_c <=> f6p_c;4.860861146496871;-2.144450919241426
PGK;b0114;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-13.888433803250866
PGL;b0114;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;11.98112825452808
PGM;b0114;;2pg_c <=> 3pg_c;-14.716139568742859;-12.696576698806151
PIt2r;b0114;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;2.930805300882891
PPC;b0114;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.2830118439149403
PPCK;b0114;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b0114;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b0114;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b0114;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;0.0
PYRt2;b0114;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b0114;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;7.414753805152278
RPI;b0114;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-4.566374449375802
SUCCt2_2;b0114;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b0114;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b0114;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;3.8977075591615895
SUCOAS;b0114;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-3.8977075591615895
TALA;b0114;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;3.8511805171164277
THD2;b0114;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b0114;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;3.851180517116427
TKT2;b0114;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;3.563573288035852
TPI;b0114;;dhap_c <=> g3p_c;7.477381962160304;5.213817144797803
ACALD;b0115;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b0115;;acald_e <=> acald_c;0.0;0.0
ACKr;b0115;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b0115;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;4.7572627931090485
ACONTb;b0115;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;4.7572627931090485
ACt2r;b0115;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b0115;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b0115;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;3.8977075591615886
AKGt2r;b0115;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b0115;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b0115;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b0115;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;43.67177423054356
Biomass_Ecoli_core;b0115;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.7966959254309566
CO2t;b0115;;co2_e <=> co2_c;-22.809833310205086;-18.353086762883734
CS;b0115;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;4.757262793109048
CYTBD;b0115;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;42.60717298942521
D_LACt2;b0115;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b0115;;2pg_c <=> h2o_c + pep_c;14.716139568742859;12.69657669880616
ETOHt2r;b0115;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b0115;;ac_e --> ;0.0;0.0
EX_acald_e;b0115;;acald_e --> ;0.0;0.0
EX_akg_e;b0115;;akg_e --> ;0.0;0.0
EX_co2_e;b0115;;co2_e <=> ;22.809833310205086;18.353086762883734
EX_etoh_e;b0115;;etoh_e --> ;0.0;0.0
EX_for_e;b0115;;for_e --> ;0.0;7.743119782439188
EX_fru_e;b0115;;fru_e --> ;0.0;0.0
EX_fum_e;b0115;;fum_e --> ;0.0;0.0
EX_glc__D_e;b0115;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b0115;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b0115;;glu__L_e --> ;0.0;0.0
EX_h_e;b0115;;h_e <=> ;17.530865429786523;23.724840046584138
EX_h2o_e;b0115;;h2o_e <=> ;29.175827135565836;24.156538562093008
EX_lac__D_e;b0115;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b0115;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b0115;;nh4_e <=> ;-4.765319193197444;-4.344223542189918
EX_o2_e;b0115;;o2_e <=> ;-21.799492655998886;-21.303586494712604
EX_pi_e;b0115;;pi_e <=> ;-3.214895047684769;-2.930805300882857
EX_pyr_e;b0115;;pyr_e --> ;0.0;0.0
EX_succ_e;b0115;;succ_e --> ;0.0;0.0
FBA;b0115;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;5.2138171447978126
FBP;b0115;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b0115;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b0115;;for_c --> for_e;0.0;7.743119782439188
FRD7;b0115;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b0115;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b0115;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;3.8977075591615886
FUMt2_2;b0115;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b0115;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;11.981128254528052
GAPD;b0115;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;13.888433803250873
GLCpts;b0115;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b0115;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.20371514813269562
GLNabc;b0115;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b0115;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.140508394057224
GLUN;b0115;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b0115;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b0115;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b0115;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;11.981128254528048
H2Ot;b0115;;h2o_e <=> h2o_c;-29.175827135565836;-24.156538562093008
ICDHyr;b0115;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;4.7572627931090485
ICL;b0115;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b0115;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b0115;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b0115;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b0115;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;3.8977075591615886
ME1;b0115;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b0115;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b0115;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.70946543026361
NADTRHD;b0115;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;14.199736061185966
NH4t;b0115;;nh4_e <=> nh4_c;4.765319193197444;4.344223542189918
O2t;b0115;;o2_e <=> o2_c;21.799492655998886;21.303586494712604
PDH;b0115;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;0.0
PFK;b0115;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;5.2138171447978126
PFL;b0115;;coa_c + pyr_c --> accoa_c + for_c;0.0;7.743119782439187
PGI;b0115;;g6p_c <=> f6p_c;4.860861146496871;-2.144450919241396
PGK;b0115;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-13.888433803250875
PGL;b0115;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;11.981128254528052
PGM;b0115;;2pg_c <=> 3pg_c;-14.716139568742859;-12.69657669880616
PIt2r;b0115;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;2.930805300882857
PPC;b0115;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.283011843914949
PPCK;b0115;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b0115;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b0115;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b0115;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;0.0
PYRt2;b0115;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b0115;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;7.4147538051522615
RPI;b0115;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-4.566374449375788
SUCCt2_2;b0115;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b0115;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b0115;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;3.8977075591615886
SUCOAS;b0115;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-3.8977075591615886
TALA;b0115;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;3.8511805171164184
THD2;b0115;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b0115;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;3.8511805171164175
TKT2;b0115;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;3.5635732880358435
TPI;b0115;;dhap_c <=> g3p_c;7.477381962160304;5.2138171447978126
ACALD;b3916;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b3916;;acald_e <=> acald_c;0.0;0.0
ACKr;b3916;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b3916;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350332
ACONTb;b3916;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.0072495753503325
ACt2r;b3916;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b3916;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b3916;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482096
AKGt2r;b3916;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b3916;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b3916;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b3916;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517454
Biomass_Ecoli_core;b3916;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684306
CO2t;b3916;;co2_e <=> co2_c;-22.809833310205086;-22.809833310204986
CS;b3916;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350331
CYTBD;b3916;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b3916;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b3916;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742825
ETOHt2r;b3916;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b3916;;ac_e --> ;0.0;0.0
EX_acald_e;b3916;;acald_e --> ;0.0;0.0
EX_akg_e;b3916;;akg_e --> ;0.0;0.0
EX_co2_e;b3916;;co2_e <=> ;22.809833310205086;22.809833310204986
EX_etoh_e;b3916;;etoh_e --> ;0.0;0.0
EX_for_e;b3916;;for_e --> ;0.0;0.0
EX_fru_e;b3916;;fru_e --> ;0.0;0.0
EX_fum_e;b3916;;fum_e --> ;0.0;0.0
EX_glc__D_e;b3916;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b3916;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b3916;;glu__L_e --> ;0.0;0.0
EX_h_e;b3916;;h_e <=> ;17.530865429786523;17.530865429786747
EX_h2o_e;b3916;;h2o_e <=> ;29.175827135565836;29.17582713556578
EX_lac__D_e;b3916;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b3916;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b3916;;nh4_e <=> ;-4.765319193197444;-4.765319193197458
EX_o2_e;b3916;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b3916;;pi_e <=> ;-3.214895047684769;-3.214895047684762
EX_pyr_e;b3916;;pyr_e --> ;0.0;0.0
EX_succ_e;b3916;;succ_e --> ;0.0;0.0
FBA;b3916;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.47738196216028
FBP;b3916;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b3916;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b3916;;for_c --> for_e;0.0;0.0
FRD7;b3916;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b3916;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b3916;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482097
FUMt2_2;b3916;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b3916;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574671
GAPD;b3916;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167597
GLCpts;b3916;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b3916;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.2234617293318277
GLNabc;b3916;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b3916;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.541857463865631
GLUN;b3916;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b3916;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b3916;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b3916;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.959984944574671
H2Ot;b3916;;h2o_e <=> h2o_c;-29.175827135565836;-29.17582713556578
ICDHyr;b3916;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350332
ICL;b3916;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b3916;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b3916;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b3916;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b3916;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482097
ME1;b3916;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b3916;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b3916;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.53460965051543
NADTRHD;b3916;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b3916;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b3916;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b3916;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.282532599166615
PFK;b3916;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.47738196216028
PFL;b3916;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b3916;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496812
PGK;b3916;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.0235261431676
PGL;b3916;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574672
PGM;b3916;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742825
PIt2r;b3916;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684762
PPC;b3916;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.50430947036873
PPCK;b3916;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b3916;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b3916;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b3916;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067857
PYRt2;b3916;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b3916;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507539
RPI;b3916;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671326
SUCCt2_2;b3916;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b3916;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b3916;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482097
SUCOAS;b3916;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482097
TALA;b3916;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615714
THD2;b3916;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b3916;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615714
TKT2;b3916;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245968
TPI;b3916;;dhap_c <=> g3p_c;7.477381962160304;7.47738196216028
ACALD;b1723;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b1723;;acald_e <=> acald_c;0.0;0.0
ACKr;b1723;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b1723;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b1723;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b1723;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b1723;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b1723;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b1723;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b1723;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b1723;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b1723;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b1723;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b1723;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b1723;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b1723;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b1723;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b1723;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b1723;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b1723;;ac_e --> ;0.0;0.0
EX_acald_e;b1723;;acald_e --> ;0.0;0.0
EX_akg_e;b1723;;akg_e --> ;0.0;0.0
EX_co2_e;b1723;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b1723;;etoh_e --> ;0.0;0.0
EX_for_e;b1723;;for_e --> ;0.0;0.0
EX_fru_e;b1723;;fru_e --> ;0.0;0.0
EX_fum_e;b1723;;fum_e --> ;0.0;0.0
EX_glc__D_e;b1723;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b1723;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b1723;;glu__L_e --> ;0.0;0.0
EX_h_e;b1723;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b1723;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b1723;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b1723;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b1723;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b1723;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b1723;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b1723;;pyr_e --> ;0.0;0.0
EX_succ_e;b1723;;succ_e --> ;0.0;0.0
FBA;b1723;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b1723;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b1723;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b1723;;for_c --> for_e;0.0;0.0
FRD7;b1723;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b1723;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b1723;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b1723;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b1723;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b1723;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b1723;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b1723;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b1723;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b1723;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b1723;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b1723;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b1723;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b1723;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b1723;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b1723;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b1723;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b1723;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b1723;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b1723;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b1723;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b1723;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b1723;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b1723;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b1723;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b1723;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b1723;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b1723;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b1723;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b1723;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b1723;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b1723;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b1723;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b1723;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b1723;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b1723;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b1723;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b1723;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b1723;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b1723;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b1723;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b1723;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b1723;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b1723;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b1723;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b1723;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b1723;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b1723;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b1723;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b1723;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b1723;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b1723;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b0902;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b0902;;acald_e <=> acald_c;0.0;0.0
ACKr;b0902;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b0902;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b0902;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b0902;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b0902;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b0902;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b0902;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b0902;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b0902;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b0902;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b0902;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b0902;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b0902;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b0902;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b0902;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b0902;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b0902;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b0902;;ac_e --> ;0.0;0.0
EX_acald_e;b0902;;acald_e --> ;0.0;0.0
EX_akg_e;b0902;;akg_e --> ;0.0;0.0
EX_co2_e;b0902;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b0902;;etoh_e --> ;0.0;0.0
EX_for_e;b0902;;for_e --> ;0.0;0.0
EX_fru_e;b0902;;fru_e --> ;0.0;0.0
EX_fum_e;b0902;;fum_e --> ;0.0;0.0
EX_glc__D_e;b0902;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b0902;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b0902;;glu__L_e --> ;0.0;0.0
EX_h_e;b0902;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b0902;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b0902;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b0902;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b0902;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b0902;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b0902;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b0902;;pyr_e --> ;0.0;0.0
EX_succ_e;b0902;;succ_e --> ;0.0;0.0
FBA;b0902;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b0902;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b0902;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b0902;;for_c --> for_e;0.0;0.0
FRD7;b0902;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b0902;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b0902;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b0902;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b0902;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b0902;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b0902;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b0902;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b0902;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b0902;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b0902;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b0902;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b0902;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b0902;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b0902;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b0902;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b0902;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b0902;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b0902;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b0902;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b0902;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b0902;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b0902;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b0902;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b0902;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b0902;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b0902;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b0902;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b0902;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b0902;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b0902;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b0902;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b0902;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b0902;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b0902;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b0902;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b0902;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b0902;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b0902;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b0902;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b0902;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b0902;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b0902;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b0902;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b0902;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b0902;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b0902;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b0902;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b0902;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b0902;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b0902;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b0902;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b0903;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b0903;;acald_e <=> acald_c;0.0;0.0
ACKr;b0903;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b0903;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b0903;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b0903;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b0903;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b0903;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b0903;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b0903;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b0903;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b0903;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b0903;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b0903;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b0903;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b0903;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b0903;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b0903;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b0903;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b0903;;ac_e --> ;0.0;0.0
EX_acald_e;b0903;;acald_e --> ;0.0;0.0
EX_akg_e;b0903;;akg_e --> ;0.0;0.0
EX_co2_e;b0903;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b0903;;etoh_e --> ;0.0;0.0
EX_for_e;b0903;;for_e --> ;0.0;0.0
EX_fru_e;b0903;;fru_e --> ;0.0;0.0
EX_fum_e;b0903;;fum_e --> ;0.0;0.0
EX_glc__D_e;b0903;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b0903;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b0903;;glu__L_e --> ;0.0;0.0
EX_h_e;b0903;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b0903;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b0903;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b0903;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b0903;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b0903;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b0903;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b0903;;pyr_e --> ;0.0;0.0
EX_succ_e;b0903;;succ_e --> ;0.0;0.0
FBA;b0903;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b0903;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b0903;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b0903;;for_c --> for_e;0.0;0.0
FRD7;b0903;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b0903;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b0903;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b0903;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b0903;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b0903;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b0903;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b0903;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b0903;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b0903;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b0903;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b0903;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b0903;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b0903;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b0903;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b0903;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b0903;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b0903;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b0903;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b0903;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b0903;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b0903;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b0903;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b0903;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b0903;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b0903;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b0903;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b0903;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b0903;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b0903;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b0903;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b0903;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b0903;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b0903;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b0903;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b0903;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b0903;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b0903;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b0903;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b0903;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b0903;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b0903;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b0903;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b0903;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b0903;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b0903;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b0903;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b0903;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b0903;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b0903;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b0903;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b0903;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b2579;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b2579;;acald_e <=> acald_c;0.0;0.0
ACKr;b2579;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b2579;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b2579;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b2579;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b2579;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b2579;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b2579;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b2579;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b2579;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b2579;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b2579;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b2579;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b2579;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b2579;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b2579;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b2579;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b2579;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b2579;;ac_e --> ;0.0;0.0
EX_acald_e;b2579;;acald_e --> ;0.0;0.0
EX_akg_e;b2579;;akg_e --> ;0.0;0.0
EX_co2_e;b2579;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b2579;;etoh_e --> ;0.0;0.0
EX_for_e;b2579;;for_e --> ;0.0;0.0
EX_fru_e;b2579;;fru_e --> ;0.0;0.0
EX_fum_e;b2579;;fum_e --> ;0.0;0.0
EX_glc__D_e;b2579;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b2579;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b2579;;glu__L_e --> ;0.0;0.0
EX_h_e;b2579;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b2579;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b2579;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b2579;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b2579;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b2579;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b2579;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b2579;;pyr_e --> ;0.0;0.0
EX_succ_e;b2579;;succ_e --> ;0.0;0.0
FBA;b2579;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b2579;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b2579;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b2579;;for_c --> for_e;0.0;0.0
FRD7;b2579;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b2579;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b2579;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b2579;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b2579;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b2579;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b2579;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b2579;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b2579;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b2579;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b2579;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b2579;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b2579;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b2579;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b2579;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b2579;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b2579;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b2579;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b2579;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b2579;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b2579;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b2579;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b2579;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b2579;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b2579;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b2579;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b2579;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b2579;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b2579;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b2579;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b2579;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b2579;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b2579;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b2579;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b2579;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b2579;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b2579;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b2579;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b2579;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b2579;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b2579;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b2579;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b2579;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b2579;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b2579;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b2579;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b2579;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b2579;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b2579;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b2579;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b2579;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b2579;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b3114;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b3114;;acald_e <=> acald_c;0.0;0.0
ACKr;b3114;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b3114;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b3114;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b3114;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b3114;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b3114;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b3114;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b3114;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b3114;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b3114;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b3114;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b3114;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b3114;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b3114;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b3114;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b3114;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b3114;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b3114;;ac_e --> ;0.0;0.0
EX_acald_e;b3114;;acald_e --> ;0.0;0.0
EX_akg_e;b3114;;akg_e --> ;0.0;0.0
EX_co2_e;b3114;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b3114;;etoh_e --> ;0.0;0.0
EX_for_e;b3114;;for_e --> ;0.0;0.0
EX_fru_e;b3114;;fru_e --> ;0.0;0.0
EX_fum_e;b3114;;fum_e --> ;0.0;0.0
EX_glc__D_e;b3114;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b3114;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b3114;;glu__L_e --> ;0.0;0.0
EX_h_e;b3114;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b3114;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b3114;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b3114;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b3114;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b3114;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b3114;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b3114;;pyr_e --> ;0.0;0.0
EX_succ_e;b3114;;succ_e --> ;0.0;0.0
FBA;b3114;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b3114;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b3114;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b3114;;for_c --> for_e;0.0;0.0
FRD7;b3114;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b3114;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b3114;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b3114;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b3114;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b3114;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b3114;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b3114;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b3114;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b3114;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b3114;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b3114;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b3114;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b3114;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b3114;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b3114;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b3114;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b3114;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b3114;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b3114;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b3114;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b3114;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b3114;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b3114;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b3114;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b3114;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b3114;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b3114;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b3114;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b3114;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b3114;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b3114;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b3114;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b3114;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b3114;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b3114;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b3114;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b3114;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b3114;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b3114;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b3114;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b3114;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b3114;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b3114;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b3114;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b3114;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b3114;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b3114;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b3114;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b3114;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b3114;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b3114;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b3952;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b3952;;acald_e <=> acald_c;0.0;0.0
ACKr;b3952;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b3952;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b3952;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b3952;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b3952;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b3952;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b3952;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b3952;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b3952;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b3952;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b3952;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b3952;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b3952;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b3952;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b3952;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b3952;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b3952;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b3952;;ac_e --> ;0.0;0.0
EX_acald_e;b3952;;acald_e --> ;0.0;0.0
EX_akg_e;b3952;;akg_e --> ;0.0;0.0
EX_co2_e;b3952;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b3952;;etoh_e --> ;0.0;0.0
EX_for_e;b3952;;for_e --> ;0.0;0.0
EX_fru_e;b3952;;fru_e --> ;0.0;0.0
EX_fum_e;b3952;;fum_e --> ;0.0;0.0
EX_glc__D_e;b3952;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b3952;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b3952;;glu__L_e --> ;0.0;0.0
EX_h_e;b3952;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b3952;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b3952;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b3952;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b3952;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b3952;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b3952;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b3952;;pyr_e --> ;0.0;0.0
EX_succ_e;b3952;;succ_e --> ;0.0;0.0
FBA;b3952;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b3952;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b3952;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b3952;;for_c --> for_e;0.0;0.0
FRD7;b3952;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b3952;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b3952;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b3952;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b3952;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b3952;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b3952;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b3952;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b3952;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b3952;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b3952;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b3952;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b3952;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b3952;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b3952;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b3952;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b3952;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b3952;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b3952;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b3952;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b3952;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b3952;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b3952;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b3952;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b3952;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b3952;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b3952;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b3952;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b3952;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b3952;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b3952;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b3952;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b3952;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b3952;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b3952;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b3952;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b3952;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b3952;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b3952;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b3952;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b3952;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b3952;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b3952;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b3952;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b3952;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b3952;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b3952;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b3952;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b3952;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b3952;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b3952;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b3952;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b3951;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b3951;;acald_e <=> acald_c;0.0;0.0
ACKr;b3951;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b3951;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b3951;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b3951;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b3951;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b3951;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b3951;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b3951;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b3951;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b3951;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b3951;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b3951;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b3951;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b3951;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b3951;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b3951;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b3951;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b3951;;ac_e --> ;0.0;0.0
EX_acald_e;b3951;;acald_e --> ;0.0;0.0
EX_akg_e;b3951;;akg_e --> ;0.0;0.0
EX_co2_e;b3951;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b3951;;etoh_e --> ;0.0;0.0
EX_for_e;b3951;;for_e --> ;0.0;0.0
EX_fru_e;b3951;;fru_e --> ;0.0;0.0
EX_fum_e;b3951;;fum_e --> ;0.0;0.0
EX_glc__D_e;b3951;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b3951;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b3951;;glu__L_e --> ;0.0;0.0
EX_h_e;b3951;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b3951;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b3951;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b3951;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b3951;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b3951;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b3951;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b3951;;pyr_e --> ;0.0;0.0
EX_succ_e;b3951;;succ_e --> ;0.0;0.0
FBA;b3951;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b3951;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b3951;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b3951;;for_c --> for_e;0.0;0.0
FRD7;b3951;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b3951;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b3951;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b3951;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b3951;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b3951;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b3951;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b3951;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b3951;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b3951;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b3951;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b3951;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b3951;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b3951;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b3951;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b3951;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b3951;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b3951;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b3951;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b3951;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b3951;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b3951;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b3951;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b3951;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b3951;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b3951;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b3951;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b3951;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b3951;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b3951;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b3951;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b3951;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b3951;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b3951;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b3951;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b3951;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b3951;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b3951;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b3951;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b3951;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b3951;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b3951;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b3951;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b3951;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b3951;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b3951;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b3951;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b3951;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b3951;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b3951;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b3951;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b3951;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b4025;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b4025;;acald_e <=> acald_c;0.0;0.0
ACKr;b4025;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b4025;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;4.538181622705607
ACONTb;b4025;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;4.538181622705607
ACt2r;b4025;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b4025;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b4025;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;3.6069187818279422
AKGt2r;b4025;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b4025;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b4025;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b4025;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;47.84702679234286
Biomass_Ecoli_core;b4025;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8631595522084181
CO2t;b4025;;co2_e <=> co2_c;-22.809833310205086;-23.267813675994688
CS;b4025;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;4.538181622705607
CYTBD;b4025;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;44.53982983537307
D_LACt2;b4025;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b4025;;2pg_c <=> h2o_c + pep_c;14.716139568742859;13.139825508328153
ETOHt2r;b4025;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b4025;;ac_e --> ;0.0;0.0
EX_acald_e;b4025;;acald_e --> ;0.0;0.0
EX_akg_e;b4025;;akg_e --> ;0.0;0.0
EX_co2_e;b4025;;co2_e <=> ;22.809833310205086;23.267813675994688
EX_etoh_e;b4025;;etoh_e --> ;0.0;0.0
EX_for_e;b4025;;for_e --> ;0.0;0.0
EX_fru_e;b4025;;fru_e --> ;0.0;0.0
EX_fum_e;b4025;;fum_e --> ;0.0;0.0
EX_glc__D_e;b4025;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b4025;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b4025;;glu__L_e --> ;0.0;0.0
EX_h_e;b4025;;h_e <=> ;17.530865429786523;17.31498061730091
EX_h2o_e;b4025;;h2o_e <=> ;29.175827135565836;29.55541311810171
EX_lac__D_e;b4025;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b4025;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b4025;;nh4_e <=> ;-4.765319193197444;-4.706636406282061
EX_o2_e;b4025;;o2_e <=> ;-21.799492655998886;-22.26991491768653
EX_pi_e;b4025;;pi_e <=> ;-3.214895047684769;-3.175305044709139
EX_pyr_e;b4025;;pyr_e --> ;0.0;0.0
EX_succ_e;b4025;;succ_e --> ;0.0;0.0
FBA;b4025;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;5.867064429485867
FBP;b4025;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b4025;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b4025;;for_c --> for_e;0.0;0.0
FRD7;b4025;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b4025;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b4025;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;3.6069187818279422
FUMt2_2;b4025;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b4025;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;9.823052291797264
GAPD;b4025;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;14.431112198431945
GLCpts;b4025;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b4025;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22070989749969247
GLNabc;b4025;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b4025;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.485926508782369
GLUN;b4025;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b4025;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b4025;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b4025;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;9.82305229179726
H2Ot;b4025;;h2o_e <=> h2o_c;-29.175827135565836;-29.55541311810171
ICDHyr;b4025;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;4.538181622705607
ICL;b4025;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b4025;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b4025;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b4025;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b4025;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;3.6069187818279422
ME1;b4025;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b4025;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b4025;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;40.93291105354512
NADTRHD;b4025;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;8.453203367301713
NH4t;b4025;;nh4_e <=> nh4_c;4.765319193197444;4.706636406282061
O2t;b4025;;o2_e <=> o2_c;21.799492655998886;22.26991491768653
PDH;b4025;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;7.773130992472316
PFK;b4025;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;5.867064429485868
PFL;b4025;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b4025;;g6p_c --> f6p_c;4.860861146496871;0.0
PGK;b4025;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-14.431112198431947
PGL;b4025;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;9.823052291797262
PGM;b4025;;2pg_c <=> 3pg_c;-14.716139568742859;-13.139825508328153
PIt2r;b4025;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.175305044709139
PPC;b4025;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.4734700128084395
PPCK;b4025;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b4025;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b4025;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b4025;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;0.2182893719683217
PYRt2;b4025;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b4025;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;5.928262441737431
RPI;b4025;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-3.894789850059832
SUCCt2_2;b4025;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b4025;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b4025;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;3.6069187818279422
SUCOAS;b4025;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-3.6069187818279422
TALA;b4025;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;3.1199315200423348
THD2;b4025;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b4025;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;3.1199315200423343
TKT2;b4025;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;2.808330921695096
TPI;b4025;;dhap_c <=> g3p_c;7.477381962160304;5.867064429485867
ACALD;b2926;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b2926;;acald_e <=> acald_c;0.0;0.0
ACKr;b2926;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b2926;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;-2.3338418216545344e-17
ACONTb;b2926;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;-2.3338418216545313e-17
ACt2r;b2926;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b2926;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.6453846153846164
AKGDH;b2926;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0
AKGt2r;b2926;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b2926;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b2926;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b2926;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;9.680769230769242
Biomass_Ecoli_core;b2926;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;1.4471852414284364e-16
CO2t;b2926;;co2_e <=> co2_c;-22.809833310205086;-3.872307692307697
CS;b2926;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;-2.3338418216545344e-17
CYTBD;b2926;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;7.7446153846153925
D_LACt2;b2926;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b2926;;2pg_c <=> h2o_c + pep_c;14.716139568742859;-2.1649891211769406e-16
ETOHt2r;b2926;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b2926;;ac_e --> ;0.0;0.0
EX_acald_e;b2926;;acald_e --> ;0.0;0.0
EX_akg_e;b2926;;akg_e --> ;0.0;0.0
EX_co2_e;b2926;;co2_e <=> ;22.809833310205086;3.872307692307697
EX_etoh_e;b2926;;etoh_e --> ;0.0;0.0
EX_for_e;b2926;;for_e --> ;0.0;0.0
EX_fru_e;b2926;;fru_e --> ;0.0;0.0
EX_fum_e;b2926;;fum_e --> ;0.0;0.0
EX_glc__D_e;b2926;;glc__D_e <=> ;-10.0;-0.6453846153846179
EX_gln__L_e;b2926;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b2926;;glu__L_e --> ;0.0;0.0
EX_h_e;b2926;;h_e <=> ;17.530865429786523;0.0
EX_h2o_e;b2926;;h2o_e <=> ;29.175827135565836;3.872307692307699
EX_lac__D_e;b2926;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b2926;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b2926;;nh4_e <=> ;-4.765319193197444;-7.891211684460975e-16
EX_o2_e;b2926;;o2_e <=> ;-21.799492655998886;-3.872307692307696
EX_pi_e;b2926;;pi_e <=> ;-3.214895047684769;8.058228228858859e-15
EX_pyr_e;b2926;;pyr_e --> ;0.0;0.0
EX_succ_e;b2926;;succ_e --> ;0.0;0.0
FBA;b2926;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;-0.6453846153846151
FBP;b2926;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.6453846153846151
FORt2;b2926;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b2926;;for_c --> for_e;0.0;0.0
FRD7;b2926;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b2926;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b2926;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;4.3830525039608783e-16
FUMt2_2;b2926;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b2926;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;3.8723076923076976
GAPD;b2926;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;0.0
GLCpts;b2926;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;0.6453846153846172
GLNS;b2926;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;3.700452662332512e-17
GLNabc;b2926;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b2926;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-7.521166418227726e-16
GLUN;b2926;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b2926;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b2926;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b2926;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;3.8723076923076976
H2Ot;b2926;;h2o_e <=> h2o_c;-29.175827135565836;-3.872307692307699
ICDHyr;b2926;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;2.849877858256459e-16
ICL;b2926;;icit_c --> glx_c + succ_c;0.0;-3.0832620404219124e-16
LDH_D;b2926;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b2926;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;-3.0832620404219124e-16
MALt2_2;b2926;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b2926;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;1.299790463538966e-16
ME1;b2926;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b2926;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b2926;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;7.744615384615392
NADTRHD;b2926;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;7.74461538461539
NH4t;b2926;;nh4_e <=> nh4_c;4.765319193197444;7.891211684460975e-16
O2t;b2926;;o2_e <=> o2_c;21.799492655998886;3.872307692307696
PDH;b2926;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;0.0
PFK;b2926;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;0.0
PFL;b2926;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b2926;;g6p_c <=> f6p_c;4.860861146496871;-3.2269230769230806
PGK;b2926;;3pg_c + atp_c --> 13dpg_c + adp_c;-16.02352614316763;0.0
PGL;b2926;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;3.872307692307698
PGM;b2926;;2pg_c <=> 3pg_c;-14.716139568742859;2.1649891211769406e-16
PIt2r;b2926;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;-8.058228228858859e-15
PPC;b2926;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;1.0525112251557681e-16
PPCK;b2926;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b2926;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.6453846153846164
PTAr;b2926;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b2926;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;0.0
PYRt2;b2926;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b2926;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.581538461538465
RPI;b2926;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-1.290769230769233
SUCCt2_2;b2926;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b2926;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b2926;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;4.3830525039608783e-16
SUCOAS;b2926;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-7.466314544382791e-16
TALA;b2926;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.2907692307692327
THD2;b2926;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b2926;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.2907692307692327
TKT2;b2926;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.2907692307692327
TPI;b2926;;dhap_c <=> g3p_c;7.477381962160304;-0.6453846153846151
ACALD;b0767;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b0767;;acald_e <=> acald_c;0.0;0.0
ACKr;b0767;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b0767;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;7.80330159512732
ACONTb;b0767;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;7.80330159512732
ACt2r;b0767;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b0767;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b0767;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;6.871333415503455
AKGt2r;b0767;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b0767;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b0767;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b0767;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;41.35354605121257
Biomass_Ecoli_core;b0767;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8638133095040013
CO2t;b0767;;co2_e <=> co2_c;-22.809833310205086;-23.239992707402532
CS;b0767;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;7.803301595127319
CYTBD;b0767;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;44.4826762805699
D_LACt2;b0767;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b0767;;2pg_c <=> h2o_c + pep_c;14.716139568742859;16.41146036832753
ETOHt2r;b0767;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b0767;;ac_e --> ;0.0;0.0
EX_acald_e;b0767;;acald_e --> ;0.0;0.0
EX_akg_e;b0767;;akg_e --> ;0.0;0.0
EX_co2_e;b0767;;co2_e <=> ;22.809833310205086;23.239992707402532
EX_etoh_e;b0767;;etoh_e --> ;0.0;0.0
EX_for_e;b0767;;for_e --> ;0.0;0.0
EX_fru_e;b0767;;fru_e --> ;0.0;0.0
EX_fum_e;b0767;;fum_e --> ;0.0;0.0
EX_glc__D_e;b0767;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b0767;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b0767;;glu__L_e --> ;0.0;0.0
EX_h_e;b0767;;h_e <=> ;17.530865429786523;17.328094988650253
EX_h2o_e;b0767;;h2o_e <=> ;29.175827135565836;29.53235437915348
EX_lac__D_e;b0767;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b0767;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b0767;;nh4_e <=> ;-4.765319193197444;-4.710201214063416
EX_o2_e;b0767;;o2_e <=> ;-21.799492655998886;-22.241338140284945
EX_pi_e;b0767;;pi_e <=> ;-3.214895047684769;-3.1777100216723944
EX_pyr_e;b0767;;pyr_e --> ;0.0;0.0
EX_succ_e;b0767;;succ_e --> ;0.0;0.0
FBA;b0767;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;9.14076490103637
FBP;b0767;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b0767;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b0767;;for_c --> for_e;0.0;0.0
FRD7;b0767;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b0767;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b0767;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;6.871333415503455
FUMt2_2;b0767;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b0767;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;1.5294541852809653e-14
GAPD;b0767;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;17.703725079345514
GLCpts;b0767;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000005
GLNS;b0767;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.2208770632401731
GLNabc;b0767;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b0767;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.4893241508232435
GLUN;b0767;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b0767;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b0767;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b0767;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;1.5294541852809653e-14
H2Ot;b0767;;h2o_e <=> h2o_c;-29.175827135565836;-29.53235437915348
ICDHyr;b0767;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;7.80330159512732
ICL;b0767;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b0767;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b0767;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b0767;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b0767;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;6.871333415503455
ME1;b0767;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b0767;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b0767;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;37.61134286506644
NADTRHD;b0767;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b0767;;nh4_e <=> nh4_c;4.765319193197444;4.710201214063416
O2t;b0767;;o2_e <=> o2_c;21.799492655998886;22.241338140284945
PDH;b0767;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;11.040701116486408
PFK;b0767;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;9.140764901036375
PFL;b0767;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b0767;;g6p_c <=> f6p_c;4.860861146496871;9.822918271551679
PGK;b0767;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-17.703725079345517
PGL;b0767;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;0.0
PGM;b0767;;2pg_c <=> 3pg_c;-14.716139568742859;-16.41146036832753
PIt2r;b0767;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.1777100216723944
PPC;b0767;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.475343419714662
PPCK;b0767;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b0767;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b0767;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b0767;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;3.4877114596493364
PYRt2;b0767;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b0767;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;-0.6209090068714703
RPI;b0767;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-0.6209090068714856
SUCCt2_2;b0767;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b0767;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b0767;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;6.871333415503455
SUCOAS;b0767;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-6.871333415503455
TALA;b0767;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;-0.15453620107026306
THD2;b0767;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;7.939695970583087
TKT1;b0767;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;-0.15453620107026306
TKT2;b0767;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;-0.4663728058012074
TPI;b0767;;dhap_c <=> g3p_c;7.477381962160304;9.14076490103637
ACALD;b0755;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b0755;;acald_e <=> acald_c;0.0;0.0
ACKr;b0755;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b0755;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350332
ACONTb;b0755;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.0072495753503325
ACt2r;b0755;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b0755;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b0755;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482096
AKGt2r;b0755;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b0755;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b0755;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b0755;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.51400977451748
Biomass_Ecoli_core;b0755;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684311
CO2t;b0755;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b0755;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350331
CYTBD;b0755;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199754
D_LACt2;b0755;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b0755;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.71613956874283
ETOHt2r;b0755;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b0755;;ac_e --> ;0.0;0.0
EX_acald_e;b0755;;acald_e --> ;0.0;0.0
EX_akg_e;b0755;;akg_e --> ;0.0;0.0
EX_co2_e;b0755;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b0755;;etoh_e --> ;0.0;0.0
EX_for_e;b0755;;for_e --> ;0.0;0.0
EX_fru_e;b0755;;fru_e --> ;0.0;0.0
EX_fum_e;b0755;;fum_e --> ;0.0;0.0
EX_glc__D_e;b0755;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b0755;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b0755;;glu__L_e --> ;0.0;0.0
EX_h_e;b0755;;h_e <=> ;17.530865429786523;17.530865429786658
EX_h2o_e;b0755;;h2o_e <=> ;29.175827135565836;29.1758271355658
EX_lac__D_e;b0755;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b0755;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b0755;;nh4_e <=> ;-4.765319193197444;-4.76531919319746
EX_o2_e;b0755;;o2_e <=> ;-21.799492655998886;-21.799492655998765
EX_pi_e;b0755;;pi_e <=> ;-3.214895047684769;-3.2148950476847737
EX_pyr_e;b0755;;pyr_e --> ;0.0;0.0
EX_succ_e;b0755;;succ_e --> ;0.0;0.0
FBA;b0755;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.4773819621602815
FBP;b0755;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b0755;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b0755;;for_c --> for_e;0.0;0.0
FRD7;b0755;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b0755;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b0755;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482096
FUMt2_2;b0755;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b0755;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574661
GAPD;b0755;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167604
GLCpts;b0755;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b0755;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182779
GLNabc;b0755;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b0755;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.541857463865632
GLUN;b0755;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b0755;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b0755;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b0755;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.959984944574659
H2Ot;b0755;;h2o_e <=> h2o_c;-29.175827135565836;-29.1758271355658
ICDHyr;b0755;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350332
ICL;b0755;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b0755;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b0755;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b0755;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b0755;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482096
ME1;b0755;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b0755;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b0755;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b0755;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b0755;;nh4_e <=> nh4_c;4.765319193197444;4.76531919319746
O2t;b0755;;o2_e <=> o2_c;21.799492655998886;21.799492655998765
PDH;b0755;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.282532599166617
PFK;b0755;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160282
PFL;b0755;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b0755;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496813
PGK;b0755;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.023526143167608
PGL;b0755;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.95998494457466
PGM;b0755;;2pg_c <=> 3pg_c;-14.716139568742859;-14.71613956874283
PIt2r;b0755;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.2148950476847737
PPC;b0755;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.504309470368731
PPCK;b0755;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b0755;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b0755;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b0755;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067861
PYRt2;b0755;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b0755;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.6784818505075307
RPI;b0755;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.281503094067128
SUCCt2_2;b0755;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b0755;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b0755;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482097
SUCOAS;b0755;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482097
TALA;b0755;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615676
THD2;b0755;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b0755;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615674
TKT2;b0755;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245964
TPI;b0755;;dhap_c <=> g3p_c;7.477381962160304;7.4773819621602815
ACALD;b3612;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b3612;;acald_e <=> acald_c;0.0;0.0
ACKr;b3612;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b3612;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b3612;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b3612;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b3612;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b3612;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b3612;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b3612;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b3612;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b3612;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b3612;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b3612;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b3612;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b3612;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b3612;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b3612;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b3612;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b3612;;ac_e --> ;0.0;0.0
EX_acald_e;b3612;;acald_e --> ;0.0;0.0
EX_akg_e;b3612;;akg_e --> ;0.0;0.0
EX_co2_e;b3612;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b3612;;etoh_e --> ;0.0;0.0
EX_for_e;b3612;;for_e --> ;0.0;0.0
EX_fru_e;b3612;;fru_e --> ;0.0;0.0
EX_fum_e;b3612;;fum_e --> ;0.0;0.0
EX_glc__D_e;b3612;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b3612;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b3612;;glu__L_e --> ;0.0;0.0
EX_h_e;b3612;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b3612;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b3612;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b3612;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b3612;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b3612;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b3612;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b3612;;pyr_e --> ;0.0;0.0
EX_succ_e;b3612;;succ_e --> ;0.0;0.0
FBA;b3612;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b3612;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b3612;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b3612;;for_c --> for_e;0.0;0.0
FRD7;b3612;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b3612;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b3612;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b3612;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b3612;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b3612;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b3612;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b3612;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b3612;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b3612;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b3612;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b3612;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b3612;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b3612;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b3612;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b3612;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b3612;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b3612;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b3612;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b3612;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b3612;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b3612;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b3612;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b3612;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b3612;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b3612;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b3612;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b3612;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b3612;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b3612;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b3612;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b3612;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b3612;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b3612;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b3612;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b3612;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b3612;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b3612;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b3612;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b3612;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b3612;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b3612;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b3612;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b3612;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b3612;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b3612;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b3612;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b3612;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b3612;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b3612;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b3612;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b3612;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b4395;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b4395;;acald_e <=> acald_c;0.0;0.0
ACKr;b4395;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b4395;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b4395;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b4395;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b4395;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b4395;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b4395;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b4395;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b4395;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b4395;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b4395;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b4395;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b4395;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b4395;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b4395;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b4395;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b4395;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b4395;;ac_e --> ;0.0;0.0
EX_acald_e;b4395;;acald_e --> ;0.0;0.0
EX_akg_e;b4395;;akg_e --> ;0.0;0.0
EX_co2_e;b4395;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b4395;;etoh_e --> ;0.0;0.0
EX_for_e;b4395;;for_e --> ;0.0;0.0
EX_fru_e;b4395;;fru_e --> ;0.0;0.0
EX_fum_e;b4395;;fum_e --> ;0.0;0.0
EX_glc__D_e;b4395;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b4395;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b4395;;glu__L_e --> ;0.0;0.0
EX_h_e;b4395;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b4395;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b4395;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b4395;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b4395;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b4395;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b4395;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b4395;;pyr_e --> ;0.0;0.0
EX_succ_e;b4395;;succ_e --> ;0.0;0.0
FBA;b4395;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b4395;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b4395;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b4395;;for_c --> for_e;0.0;0.0
FRD7;b4395;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b4395;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b4395;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b4395;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b4395;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b4395;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b4395;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b4395;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b4395;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b4395;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b4395;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b4395;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b4395;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b4395;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b4395;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b4395;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b4395;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b4395;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b4395;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b4395;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b4395;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b4395;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b4395;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b4395;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b4395;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b4395;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b4395;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b4395;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b4395;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b4395;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b4395;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b4395;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b4395;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b4395;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b4395;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b4395;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b4395;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b4395;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b4395;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b4395;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b4395;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b4395;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b4395;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b4395;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b4395;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b4395;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b4395;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b4395;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b4395;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b4395;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b4395;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b4395;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b3493;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b3493;;acald_e <=> acald_c;0.0;0.0
ACKr;b3493;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b3493;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b3493;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b3493;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b3493;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b3493;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b3493;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b3493;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b3493;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b3493;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b3493;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b3493;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b3493;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b3493;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b3493;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b3493;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b3493;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b3493;;ac_e --> ;0.0;0.0
EX_acald_e;b3493;;acald_e --> ;0.0;0.0
EX_akg_e;b3493;;akg_e --> ;0.0;0.0
EX_co2_e;b3493;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b3493;;etoh_e --> ;0.0;0.0
EX_for_e;b3493;;for_e --> ;0.0;0.0
EX_fru_e;b3493;;fru_e --> ;0.0;0.0
EX_fum_e;b3493;;fum_e --> ;0.0;0.0
EX_glc__D_e;b3493;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b3493;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b3493;;glu__L_e --> ;0.0;0.0
EX_h_e;b3493;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b3493;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b3493;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b3493;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b3493;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b3493;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b3493;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b3493;;pyr_e --> ;0.0;0.0
EX_succ_e;b3493;;succ_e --> ;0.0;0.0
FBA;b3493;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b3493;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b3493;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b3493;;for_c --> for_e;0.0;0.0
FRD7;b3493;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b3493;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b3493;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b3493;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b3493;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b3493;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b3493;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b3493;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b3493;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b3493;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b3493;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b3493;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b3493;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b3493;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b3493;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b3493;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b3493;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b3493;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b3493;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b3493;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b3493;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b3493;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b3493;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b3493;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b3493;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b3493;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b3493;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b3493;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b3493;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b3493;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b3493;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b3493;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b3493;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b3493;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b3493;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b3493;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b3493;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b3493;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b3493;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b3493;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b3493;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b3493;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b3493;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b3493;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b3493;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b3493;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b3493;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b3493;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b3493;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b3493;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b3493;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b3493;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b2987;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b2987;;acald_e <=> acald_c;0.0;0.0
ACKr;b2987;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b2987;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b2987;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b2987;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b2987;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b2987;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b2987;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b2987;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b2987;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b2987;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b2987;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b2987;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b2987;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b2987;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b2987;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b2987;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b2987;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b2987;;ac_e --> ;0.0;0.0
EX_acald_e;b2987;;acald_e --> ;0.0;0.0
EX_akg_e;b2987;;akg_e --> ;0.0;0.0
EX_co2_e;b2987;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b2987;;etoh_e --> ;0.0;0.0
EX_for_e;b2987;;for_e --> ;0.0;0.0
EX_fru_e;b2987;;fru_e --> ;0.0;0.0
EX_fum_e;b2987;;fum_e --> ;0.0;0.0
EX_glc__D_e;b2987;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b2987;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b2987;;glu__L_e --> ;0.0;0.0
EX_h_e;b2987;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b2987;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b2987;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b2987;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b2987;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b2987;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b2987;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b2987;;pyr_e --> ;0.0;0.0
EX_succ_e;b2987;;succ_e --> ;0.0;0.0
FBA;b2987;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b2987;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b2987;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b2987;;for_c --> for_e;0.0;0.0
FRD7;b2987;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b2987;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b2987;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b2987;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b2987;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b2987;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b2987;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b2987;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b2987;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b2987;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b2987;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b2987;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b2987;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b2987;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b2987;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b2987;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b2987;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b2987;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b2987;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b2987;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b2987;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b2987;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b2987;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b2987;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b2987;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b2987;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b2987;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b2987;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b2987;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b2987;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b2987;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b2987;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b2987;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b2987;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b2987;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b2987;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b2987;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b2987;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b2987;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b2987;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b2987;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b2987;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b2987;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b2987;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b2987;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b2987;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b2987;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b2987;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b2987;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b2987;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b2987;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b2987;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b3956;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b3956;;acald_e <=> acald_c;0.0;0.0
ACKr;b3956;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b3956;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;5.573611878986723
ACONTb;b3956;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;5.573611878986724
ACt2r;b3956;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b3956;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b3956;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;2.1389589908676214
AKGt2r;b3956;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b3956;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b3956;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b3956;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;46.20266690801874
Biomass_Ecoli_core;b3956;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8707448062160257
CO2t;b3956;;co2_e <=> co2_c;-22.809833310205086;-22.945019399073974
CS;b3956;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;5.573611878986723
CYTBD;b3956;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.87670265721525
D_LACt2;b3956;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b3956;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.250845096371272
ETOHt2r;b3956;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b3956;;ac_e --> ;0.0;0.0
EX_acald_e;b3956;;acald_e --> ;0.0;0.0
EX_akg_e;b3956;;akg_e --> ;0.0;0.0
EX_co2_e;b3956;;co2_e <=> ;22.809833310205086;22.945019399073974
EX_etoh_e;b3956;;etoh_e --> ;0.0;0.0
EX_for_e;b3956;;for_e --> ;0.0;0.0
EX_fru_e;b3956;;fru_e --> ;0.0;0.0
EX_fum_e;b3956;;fum_e --> ;0.0;0.0
EX_glc__D_e;b3956;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b3956;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b3956;;glu__L_e --> ;0.0;0.0
EX_h_e;b3956;;h_e <=> ;17.530865429786523;17.467140812693557
EX_h2o_e;b3956;;h2o_e <=> ;29.175827135565836;29.287872865473975
EX_lac__D_e;b3956;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b3956;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b3956;;nh4_e <=> ;-4.765319193197444;-4.747997279334743
EX_o2_e;b3956;;o2_e <=> ;-21.799492655998886;-21.93835132860762
EX_pi_e;b3956;;pi_e <=> ;-3.214895047684769;-3.2032089186269213
EX_pyr_e;b3956;;pyr_e --> ;0.0;0.0
EX_succ_e;b3956;;succ_e --> ;0.0;0.0
FBA;b3956;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.002050386091425
FBP;b3956;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b3956;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b3956;;for_c --> for_e;0.0;0.0
FRD7;b3956;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b3956;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b3956;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;4.634165307560258
FUMt2_2;b3956;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b3956;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;6.3954592654964895
GAPD;b3956;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;15.553479326470448
GLCpts;b3956;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b3956;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22264944694943775
GLNabc;b3956;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b3956;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.525347832385306
GLUN;b3956;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b3956;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b3956;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b3956;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;6.395459265496489
H2Ot;b3956;;h2o_e <=> h2o_c;-29.175827135565836;-29.287872865473975
ICDHyr;b3956;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;3.0784055622940882
ICL;b3956;;icit_c --> glx_c + succ_c;0.0;2.4952063166926357
LDH_D;b3956;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b3956;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;2.4952063166926357
MALt2_2;b3956;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b3956;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;7.129371624252893
ME1;b3956;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b3956;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b3956;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;39.24253734965499
NADTRHD;b3956;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b3956;;nh4_e <=> nh4_c;4.765319193197444;4.747997279334743
O2t;b3956;;o2_e <=> o2_c;21.799492655998886;21.93835132860762
PDH;b3956;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;11.332195580415782
PFK;b3956;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.002050386091425
PFL;b3956;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b3956;;g6p_c <=> f6p_c;4.860861146496871;3.4260380492292266
PGK;b3956;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-15.55347932647045
PGL;b3956;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;6.3954592654964895
PGM;b3956;;2pg_c <=> 3pg_c;-14.716139568742859;-14.250845096371272
PIt2r;b3956;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.2032089186269213
PPC;b3956;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;0.0
PPCK;b3956;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b3956;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b3956;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b3956;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;3.798841467464536
PYRt2;b3956;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b3956;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;3.6377481436229133
RPI;b3956;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.757711121873576
SUCCt2_2;b3956;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b3956;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b3956;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;4.634165307560258
SUCOAS;b3956;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-2.1389589908676214
TALA;b3956;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.9760435093334492
THD2;b3956;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b3956;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.976043509333449
TKT2;b3956;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.6617046342894641
TPI;b3956;;dhap_c <=> g3p_c;7.477381962160304;7.002050386091425
ACALD;b3403;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b3403;;acald_e <=> acald_c;0.0;0.0
ACKr;b3403;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b3403;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.0072495753503246
ACONTb;b3403;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.0072495753503246
ACt2r;b3403;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b3403;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b3403;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482091
AKGt2r;b3403;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b3403;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b3403;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b3403;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.51400977451743
Biomass_Ecoli_core;b3403;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684311
CO2t;b3403;;co2_e <=> co2_c;-22.809833310205086;-22.809833310204958
CS;b3403;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.0072495753503246
CYTBD;b3403;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.598985311997495
D_LACt2;b3403;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b3403;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742825
ETOHt2r;b3403;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b3403;;ac_e --> ;0.0;0.0
EX_acald_e;b3403;;acald_e --> ;0.0;0.0
EX_akg_e;b3403;;akg_e --> ;0.0;0.0
EX_co2_e;b3403;;co2_e <=> ;22.809833310205086;22.809833310204958
EX_etoh_e;b3403;;etoh_e --> ;0.0;0.0
EX_for_e;b3403;;for_e --> ;0.0;0.0
EX_fru_e;b3403;;fru_e --> ;0.0;0.0
EX_fum_e;b3403;;fum_e --> ;0.0;0.0
EX_glc__D_e;b3403;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b3403;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b3403;;glu__L_e --> ;0.0;0.0
EX_h_e;b3403;;h_e <=> ;17.530865429786523;17.530865429786765
EX_h2o_e;b3403;;h2o_e <=> ;29.175827135565836;29.175827135565715
EX_lac__D_e;b3403;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b3403;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b3403;;nh4_e <=> ;-4.765319193197444;-4.76531919319746
EX_o2_e;b3403;;o2_e <=> ;-21.799492655998886;-21.79949265599874
EX_pi_e;b3403;;pi_e <=> ;-3.214895047684769;-3.2148950476846583
EX_pyr_e;b3403;;pyr_e --> ;0.0;0.0
EX_succ_e;b3403;;succ_e --> ;0.0;0.0
FBA;b3403;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.47738196216028
FBP;b3403;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b3403;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b3403;;for_c --> for_e;0.0;0.0
FRD7;b3403;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b3403;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b3403;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482089
FUMt2_2;b3403;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b3403;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574666
GAPD;b3403;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167597
GLCpts;b3403;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b3403;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182779
GLNabc;b3403;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b3403;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.541857463865632
GLUN;b3403;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b3403;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b3403;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b3403;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.959984944574665
H2Ot;b3403;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565715
ICDHyr;b3403;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350328
ICL;b3403;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b3403;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b3403;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;-3.2834795302282726e-15
MALt2_2;b3403;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b3403;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482085
ME1;b3403;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b3403;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b3403;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.5346096505154
NADTRHD;b3403;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b3403;;nh4_e <=> nh4_c;4.765319193197444;4.76531919319746
O2t;b3403;;o2_e <=> o2_c;21.799492655998886;21.79949265599874
PDH;b3403;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.282532599166606
PFK;b3403;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.47738196216028
PFL;b3403;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b3403;;g6p_c <=> f6p_c;4.860861146496871;4.8608611464968075
PGK;b3403;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.0235261431676
PGL;b3403;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574666
PGM;b3403;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742825
PIt2r;b3403;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.2148950476846583
PPC;b3403;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687347
PPCK;b3403;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b3403;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b3403;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b3403;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067755
PYRt2;b3403;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b3403;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.6784818505075347
RPI;b3403;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.281503094067131
SUCCt2_2;b3403;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b3403;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b3403;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482089
SUCOAS;b3403;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482091
TALA;b3403;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615692
THD2;b3403;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b3403;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615692
TKT2;b3403;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.1814980932459658
TPI;b3403;;dhap_c <=> g3p_c;7.477381962160304;7.47738196216028
ACALD;b1702;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b1702;;acald_e <=> acald_c;0.0;0.0
ACKr;b1702;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b1702;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b1702;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b1702;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b1702;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b1702;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b1702;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b1702;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b1702;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b1702;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b1702;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b1702;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b1702;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b1702;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b1702;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b1702;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b1702;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b1702;;ac_e --> ;0.0;0.0
EX_acald_e;b1702;;acald_e --> ;0.0;0.0
EX_akg_e;b1702;;akg_e --> ;0.0;0.0
EX_co2_e;b1702;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b1702;;etoh_e --> ;0.0;0.0
EX_for_e;b1702;;for_e --> ;0.0;0.0
EX_fru_e;b1702;;fru_e --> ;0.0;0.0
EX_fum_e;b1702;;fum_e --> ;0.0;0.0
EX_glc__D_e;b1702;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b1702;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b1702;;glu__L_e --> ;0.0;0.0
EX_h_e;b1702;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b1702;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b1702;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b1702;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b1702;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b1702;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b1702;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b1702;;pyr_e --> ;0.0;0.0
EX_succ_e;b1702;;succ_e --> ;0.0;0.0
FBA;b1702;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b1702;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b1702;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b1702;;for_c --> for_e;0.0;0.0
FRD7;b1702;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b1702;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b1702;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b1702;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b1702;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b1702;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b1702;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b1702;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b1702;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b1702;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b1702;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b1702;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b1702;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b1702;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b1702;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b1702;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b1702;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b1702;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b1702;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b1702;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b1702;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b1702;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b1702;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b1702;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b1702;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b1702;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b1702;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b1702;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b1702;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b1702;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b1702;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b1702;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b1702;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b1702;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b1702;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b1702;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b1702;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b1702;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b1702;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b1702;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b1702;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b1702;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b1702;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b1702;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b1702;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b1702;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b1702;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b1702;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b1702;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b1702;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b1702;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b1702;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b2297;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b2297;;acald_e <=> acald_c;0.0;0.0
ACKr;b2297;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b2297;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b2297;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b2297;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b2297;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b2297;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b2297;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b2297;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b2297;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b2297;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b2297;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b2297;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b2297;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b2297;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b2297;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b2297;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b2297;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b2297;;ac_e --> ;0.0;0.0
EX_acald_e;b2297;;acald_e --> ;0.0;0.0
EX_akg_e;b2297;;akg_e --> ;0.0;0.0
EX_co2_e;b2297;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b2297;;etoh_e --> ;0.0;0.0
EX_for_e;b2297;;for_e --> ;0.0;0.0
EX_fru_e;b2297;;fru_e --> ;0.0;0.0
EX_fum_e;b2297;;fum_e --> ;0.0;0.0
EX_glc__D_e;b2297;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b2297;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b2297;;glu__L_e --> ;0.0;0.0
EX_h_e;b2297;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b2297;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b2297;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b2297;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b2297;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b2297;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b2297;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b2297;;pyr_e --> ;0.0;0.0
EX_succ_e;b2297;;succ_e --> ;0.0;0.0
FBA;b2297;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b2297;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b2297;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b2297;;for_c --> for_e;0.0;0.0
FRD7;b2297;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b2297;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b2297;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b2297;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b2297;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b2297;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b2297;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b2297;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b2297;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b2297;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b2297;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b2297;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b2297;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b2297;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b2297;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b2297;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b2297;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b2297;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b2297;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b2297;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b2297;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b2297;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b2297;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b2297;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b2297;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b2297;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b2297;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b2297;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b2297;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b2297;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b2297;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b2297;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b2297;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b2297;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b2297;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b2297;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b2297;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b2297;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b2297;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b2297;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b2297;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b2297;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b2297;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b2297;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b2297;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b2297;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b2297;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b2297;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b2297;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b2297;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b2297;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b2297;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b2458;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b2458;;acald_e <=> acald_c;0.0;0.0
ACKr;b2458;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b2458;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b2458;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b2458;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b2458;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b2458;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b2458;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b2458;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b2458;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b2458;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b2458;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b2458;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b2458;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b2458;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b2458;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b2458;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b2458;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b2458;;ac_e --> ;0.0;0.0
EX_acald_e;b2458;;acald_e --> ;0.0;0.0
EX_akg_e;b2458;;akg_e --> ;0.0;0.0
EX_co2_e;b2458;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b2458;;etoh_e --> ;0.0;0.0
EX_for_e;b2458;;for_e --> ;0.0;0.0
EX_fru_e;b2458;;fru_e --> ;0.0;0.0
EX_fum_e;b2458;;fum_e --> ;0.0;0.0
EX_glc__D_e;b2458;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b2458;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b2458;;glu__L_e --> ;0.0;0.0
EX_h_e;b2458;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b2458;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b2458;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b2458;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b2458;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b2458;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b2458;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b2458;;pyr_e --> ;0.0;0.0
EX_succ_e;b2458;;succ_e --> ;0.0;0.0
FBA;b2458;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b2458;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b2458;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b2458;;for_c --> for_e;0.0;0.0
FRD7;b2458;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b2458;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b2458;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b2458;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b2458;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b2458;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b2458;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b2458;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b2458;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b2458;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b2458;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b2458;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b2458;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b2458;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b2458;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b2458;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b2458;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b2458;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b2458;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b2458;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b2458;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b2458;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b2458;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b2458;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b2458;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b2458;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b2458;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b2458;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b2458;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b2458;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b2458;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b2458;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b2458;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b2458;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b2458;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b2458;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b2458;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b2458;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b2458;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b2458;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b2458;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b2458;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b2458;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b2458;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b2458;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b2458;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b2458;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b2458;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b2458;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b2458;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b2458;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b2458;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b1676;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b1676;;acald_e <=> acald_c;0.0;0.0
ACKr;b1676;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b1676;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b1676;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b1676;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b1676;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b1676;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b1676;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b1676;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b1676;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b1676;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b1676;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b1676;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b1676;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b1676;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b1676;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b1676;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b1676;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b1676;;ac_e --> ;0.0;0.0
EX_acald_e;b1676;;acald_e --> ;0.0;0.0
EX_akg_e;b1676;;akg_e --> ;0.0;0.0
EX_co2_e;b1676;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b1676;;etoh_e --> ;0.0;0.0
EX_for_e;b1676;;for_e --> ;0.0;0.0
EX_fru_e;b1676;;fru_e --> ;0.0;0.0
EX_fum_e;b1676;;fum_e --> ;0.0;0.0
EX_glc__D_e;b1676;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b1676;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b1676;;glu__L_e --> ;0.0;0.0
EX_h_e;b1676;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b1676;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b1676;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b1676;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b1676;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b1676;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b1676;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b1676;;pyr_e --> ;0.0;0.0
EX_succ_e;b1676;;succ_e --> ;0.0;0.0
FBA;b1676;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b1676;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b1676;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b1676;;for_c --> for_e;0.0;0.0
FRD7;b1676;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b1676;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b1676;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b1676;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b1676;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b1676;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b1676;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b1676;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b1676;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b1676;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b1676;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b1676;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b1676;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b1676;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b1676;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b1676;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b1676;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b1676;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b1676;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b1676;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b1676;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b1676;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b1676;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b1676;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b1676;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b1676;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b1676;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b1676;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b1676;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b1676;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b1676;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b1676;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b1676;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b1676;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b1676;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b1676;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b1676;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b1676;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b1676;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b1676;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b1676;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b1676;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b1676;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b1676;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b1676;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b1676;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b1676;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b1676;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b1676;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b1676;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b1676;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b1676;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b1854;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b1854;;acald_e <=> acald_c;0.0;0.0
ACKr;b1854;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b1854;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b1854;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b1854;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b1854;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b1854;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b1854;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b1854;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b1854;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b1854;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b1854;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b1854;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b1854;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b1854;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b1854;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b1854;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b1854;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b1854;;ac_e --> ;0.0;0.0
EX_acald_e;b1854;;acald_e --> ;0.0;0.0
EX_akg_e;b1854;;akg_e --> ;0.0;0.0
EX_co2_e;b1854;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b1854;;etoh_e --> ;0.0;0.0
EX_for_e;b1854;;for_e --> ;0.0;0.0
EX_fru_e;b1854;;fru_e --> ;0.0;0.0
EX_fum_e;b1854;;fum_e --> ;0.0;0.0
EX_glc__D_e;b1854;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b1854;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b1854;;glu__L_e --> ;0.0;0.0
EX_h_e;b1854;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b1854;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b1854;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b1854;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b1854;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b1854;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b1854;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b1854;;pyr_e --> ;0.0;0.0
EX_succ_e;b1854;;succ_e --> ;0.0;0.0
FBA;b1854;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b1854;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b1854;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b1854;;for_c --> for_e;0.0;0.0
FRD7;b1854;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b1854;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b1854;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b1854;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b1854;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b1854;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b1854;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b1854;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b1854;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b1854;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b1854;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b1854;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b1854;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b1854;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b1854;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b1854;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b1854;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b1854;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b1854;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b1854;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b1854;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b1854;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b1854;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b1854;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b1854;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b1854;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b1854;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b1854;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b1854;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b1854;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b1854;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b1854;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b1854;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b1854;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b1854;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b1854;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b1854;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b1854;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b1854;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b1854;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b1854;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b1854;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b1854;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b1854;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b1854;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b1854;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b1854;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b1854;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b1854;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b1854;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b1854;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b1854;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b4301;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b4301;;acald_e <=> acald_c;0.0;0.0
ACKr;b4301;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b4301;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b4301;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b4301;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b4301;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b4301;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b4301;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b4301;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b4301;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b4301;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b4301;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b4301;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b4301;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b4301;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b4301;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b4301;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b4301;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b4301;;ac_e --> ;0.0;0.0
EX_acald_e;b4301;;acald_e --> ;0.0;0.0
EX_akg_e;b4301;;akg_e --> ;0.0;0.0
EX_co2_e;b4301;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b4301;;etoh_e --> ;0.0;0.0
EX_for_e;b4301;;for_e --> ;0.0;0.0
EX_fru_e;b4301;;fru_e --> ;0.0;0.0
EX_fum_e;b4301;;fum_e --> ;0.0;0.0
EX_glc__D_e;b4301;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b4301;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b4301;;glu__L_e --> ;0.0;0.0
EX_h_e;b4301;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b4301;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b4301;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b4301;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b4301;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b4301;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b4301;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b4301;;pyr_e --> ;0.0;0.0
EX_succ_e;b4301;;succ_e --> ;0.0;0.0
FBA;b4301;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b4301;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b4301;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b4301;;for_c --> for_e;0.0;0.0
FRD7;b4301;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b4301;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b4301;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b4301;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b4301;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b4301;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b4301;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b4301;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b4301;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b4301;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b4301;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b4301;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b4301;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b4301;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b4301;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b4301;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b4301;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b4301;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b4301;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b4301;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b4301;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b4301;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b4301;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b4301;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b4301;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b4301;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b4301;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b4301;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b4301;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b4301;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b4301;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b4301;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b4301;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b4301;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b4301;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b4301;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b4301;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b4301;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b4301;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b4301;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b4301;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b4301;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b4301;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b4301;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b4301;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b4301;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b4301;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b4301;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b4301;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b4301;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b4301;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b4301;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b3386;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b3386;;acald_e <=> acald_c;0.0;0.0
ACKr;b3386;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b3386;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b3386;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b3386;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b3386;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b3386;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b3386;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b3386;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b3386;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b3386;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b3386;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b3386;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b3386;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b3386;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b3386;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b3386;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b3386;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b3386;;ac_e --> ;0.0;0.0
EX_acald_e;b3386;;acald_e --> ;0.0;0.0
EX_akg_e;b3386;;akg_e --> ;0.0;0.0
EX_co2_e;b3386;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b3386;;etoh_e --> ;0.0;0.0
EX_for_e;b3386;;for_e --> ;0.0;0.0
EX_fru_e;b3386;;fru_e --> ;0.0;0.0
EX_fum_e;b3386;;fum_e --> ;0.0;0.0
EX_glc__D_e;b3386;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b3386;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b3386;;glu__L_e --> ;0.0;0.0
EX_h_e;b3386;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b3386;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b3386;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b3386;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b3386;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b3386;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b3386;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b3386;;pyr_e --> ;0.0;0.0
EX_succ_e;b3386;;succ_e --> ;0.0;0.0
FBA;b3386;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b3386;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b3386;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b3386;;for_c --> for_e;0.0;0.0
FRD7;b3386;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b3386;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b3386;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b3386;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b3386;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b3386;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b3386;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b3386;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b3386;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b3386;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b3386;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b3386;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b3386;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b3386;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b3386;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b3386;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b3386;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b3386;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b3386;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b3386;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b3386;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b3386;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b3386;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b3386;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b3386;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b3386;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b3386;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b3386;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b3386;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b3386;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b3386;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b3386;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b3386;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b3386;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b3386;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b3386;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b3386;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b3386;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b3386;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b3386;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b3386;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b3386;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b3386;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b3386;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b3386;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b3386;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b3386;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b3386;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b3386;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b3386;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b3386;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b3386;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b2914;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b2914;;acald_e <=> acald_c;0.0;0.0
ACKr;b2914;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b2914;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b2914;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b2914;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b2914;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b2914;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b2914;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b2914;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b2914;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b2914;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b2914;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b2914;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b2914;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b2914;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b2914;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b2914;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b2914;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b2914;;ac_e --> ;0.0;0.0
EX_acald_e;b2914;;acald_e --> ;0.0;0.0
EX_akg_e;b2914;;akg_e --> ;0.0;0.0
EX_co2_e;b2914;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b2914;;etoh_e --> ;0.0;0.0
EX_for_e;b2914;;for_e --> ;0.0;0.0
EX_fru_e;b2914;;fru_e --> ;0.0;0.0
EX_fum_e;b2914;;fum_e --> ;0.0;0.0
EX_glc__D_e;b2914;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b2914;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b2914;;glu__L_e --> ;0.0;0.0
EX_h_e;b2914;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b2914;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b2914;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b2914;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b2914;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b2914;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b2914;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b2914;;pyr_e --> ;0.0;0.0
EX_succ_e;b2914;;succ_e --> ;0.0;0.0
FBA;b2914;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b2914;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b2914;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b2914;;for_c --> for_e;0.0;0.0
FRD7;b2914;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b2914;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b2914;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b2914;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b2914;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b2914;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b2914;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b2914;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b2914;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b2914;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b2914;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b2914;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b2914;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b2914;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b2914;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b2914;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b2914;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b2914;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b2914;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b2914;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b2914;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b2914;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b2914;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b2914;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b2914;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b2914;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b2914;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b2914;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b2914;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b2914;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b2914;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b2914;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b2914;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b2914;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b2914;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b2914;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b2914;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b2914;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b2914;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b2914;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b2914;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b2914;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b2914;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b2914;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b2914;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b2914;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b2914;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b2914;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b2914;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b2914;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b2914;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b2914;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b4090;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b4090;;acald_e <=> acald_c;0.0;0.0
ACKr;b4090;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b4090;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b4090;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b4090;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b4090;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b4090;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b4090;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b4090;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b4090;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b4090;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b4090;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b4090;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b4090;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b4090;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b4090;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b4090;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b4090;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b4090;;ac_e --> ;0.0;0.0
EX_acald_e;b4090;;acald_e --> ;0.0;0.0
EX_akg_e;b4090;;akg_e --> ;0.0;0.0
EX_co2_e;b4090;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b4090;;etoh_e --> ;0.0;0.0
EX_for_e;b4090;;for_e --> ;0.0;0.0
EX_fru_e;b4090;;fru_e --> ;0.0;0.0
EX_fum_e;b4090;;fum_e --> ;0.0;0.0
EX_glc__D_e;b4090;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b4090;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b4090;;glu__L_e --> ;0.0;0.0
EX_h_e;b4090;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b4090;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b4090;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b4090;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b4090;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b4090;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b4090;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b4090;;pyr_e --> ;0.0;0.0
EX_succ_e;b4090;;succ_e --> ;0.0;0.0
FBA;b4090;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b4090;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b4090;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b4090;;for_c --> for_e;0.0;0.0
FRD7;b4090;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b4090;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b4090;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b4090;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b4090;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b4090;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b4090;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b4090;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b4090;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b4090;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b4090;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b4090;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b4090;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b4090;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b4090;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b4090;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b4090;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b4090;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b4090;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b4090;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b4090;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b4090;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b4090;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b4090;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b4090;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b4090;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b4090;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b4090;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b4090;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b4090;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b4090;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b4090;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b4090;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b4090;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b4090;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b4090;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b4090;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b4090;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b4090;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b4090;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b4090;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b4090;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b4090;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b4090;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b4090;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b4090;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b4090;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b4090;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b4090;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b4090;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b4090;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b4090;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b0722;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b0722;;acald_e <=> acald_c;0.0;0.0
ACKr;b0722;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b0722;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;0.8785455808768478
ACONTb;b0722;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;0.8785455808768476
ACt2r;b0722;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b0722;;amp_c + atp_c <=> 2.0 adp_c;0.0;3.7628882410545845
AKGDH;b0722;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0
AKGt2r;b0722;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b0722;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b0722;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b0722;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;56.18179161383702
Biomass_Ecoli_core;b0722;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8142975075325308
CO2t;b0722;;co2_e <=> co2_c;-22.809833310205086;-25.347162418199428
CS;b0722;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;0.8785455808768476
CYTBD;b0722;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;48.81150613948211
D_LACt2;b0722;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b0722;;2pg_c <=> h2o_c + pep_c;14.716139568742859;8.99326453269077
ETOHt2r;b0722;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b0722;;ac_e --> ;0.0;0.0
EX_acald_e;b0722;;acald_e --> ;0.0;0.0
EX_akg_e;b0722;;akg_e --> ;0.0;0.0
EX_co2_e;b0722;;co2_e <=> ;22.809833310205086;25.347162418199428
EX_etoh_e;b0722;;etoh_e --> ;0.0;0.0
EX_for_e;b0722;;for_e --> ;0.0;0.0
EX_fru_e;b0722;;fru_e --> ;0.0;0.0
EX_fum_e;b0722;;fum_e --> ;0.0;0.0
EX_glc__D_e;b0722;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b0722;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b0722;;glu__L_e --> ;0.0;0.0
EX_h_e;b0722;;h_e <=> ;17.530865429786523;16.33480800110251
EX_h2o_e;b0722;;h2o_e <=> ;29.175827135565836;31.278831182069357
EX_lac__D_e;b0722;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b0722;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b0722;;nh4_e <=> ;-4.765319193197444;-4.440201449073384
EX_o2_e;b0722;;o2_e <=> ;-21.799492655998886;-24.405753069741053
EX_pi_e;b0722;;pi_e <=> ;-3.214895047684769;-2.995556240959951
EX_pyr_e;b0722;;pyr_e --> ;0.0;0.0
EX_succ_e;b0722;;succ_e --> ;0.0;4.817011613443951e-16
FBA;b0722;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;1.5661189374905506
FBP;b0722;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b0722;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b0722;;for_c --> for_e;0.0;0.0
FRD7;b0722;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b0722;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b0722;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;-1.27013828756454e-16
FUMt2_2;b0722;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b0722;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;22.871697995300533
GAPD;b0722;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;10.211453603959436
GLCpts;b0722;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b0722;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.20821587267606811
GLNabc;b0722;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b0722;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.2319855763973155
GLUN;b0722;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b0722;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b0722;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b0722;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;22.87169799530053
H2Ot;b0722;;h2o_e <=> h2o_c;-29.175827135565836;-31.278831182069357
ICDHyr;b0722;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.8785455808768485
ICL;b0722;;icit_c --> glx_c + succ_c;0.0;-7.828259775158612e-16
LDH_D;b0722;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b0722;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b0722;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b0722;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;-9.098398062723151e-16
ME1;b0722;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b0722;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b0722;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;48.811506139482105
NADTRHD;b0722;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;31.781369496697533
NH4t;b0722;;nh4_e <=> nh4_c;4.765319193197444;4.440201449073384
O2t;b0722;;o2_e <=> o2_c;21.799492655998886;24.405753069741053
PDH;b0722;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;3.9303697796072634
PFK;b0722;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;1.5661189374905509
PFL;b0722;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b0722;;g6p_c <=> f6p_c;4.860861146496871;-13.038628984344705
PGK;b0722;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-10.211453603959438
PGL;b0722;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;22.871697995300533
PGM;b0722;;2pg_c <=> 3pg_c;-14.716139568742859;-8.99326453269077
PIt2r;b0722;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;2.995556240959951
PPC;b0722;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.333450937585213
PPCK;b0722;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b0722;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;3.7628882410545845
PTAr;b0722;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b0722;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;0.0
PYRt2;b0722;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b0722;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;14.662481615119301
RPI;b0722;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-8.209216380181228
SUCCt2_2;b0722;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b0722;;h_e + succ_c --> h_c + succ_e;0.0;4.817011613443951e-16
SUCDi;b0722;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;0.0
SUCOAS;b0722;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-1.137513310103802e-15
TALA;b0722;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;7.478221507669273
THD2;b0722;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b0722;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;7.4782215076692715
TKT2;b0722;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;7.18426010745003
TPI;b0722;;dhap_c <=> g3p_c;7.477381962160304;1.5661189374905506
ACALD;b0724;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b0724;;acald_e <=> acald_c;0.0;0.0
ACKr;b0724;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b0724;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;0.8785455808768463
ACONTb;b0724;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;0.8785455808768463
ACt2r;b0724;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b0724;;amp_c + atp_c <=> 2.0 adp_c;0.0;3.762888241054585
AKGDH;b0724;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0
AKGt2r;b0724;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b0724;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b0724;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b0724;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;56.18179161383699
Biomass_Ecoli_core;b0724;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8142975075325308
CO2t;b0724;;co2_e <=> co2_c;-22.809833310205086;-25.347162418199396
CS;b0724;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;0.8785455808768461
CYTBD;b0724;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;48.81150613948208
D_LACt2;b0724;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b0724;;2pg_c <=> h2o_c + pep_c;14.716139568742859;8.993264532690771
ETOHt2r;b0724;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b0724;;ac_e --> ;0.0;0.0
EX_acald_e;b0724;;acald_e --> ;0.0;0.0
EX_akg_e;b0724;;akg_e --> ;0.0;0.0
EX_co2_e;b0724;;co2_e <=> ;22.809833310205086;25.347162418199396
EX_etoh_e;b0724;;etoh_e --> ;0.0;0.0
EX_for_e;b0724;;for_e --> ;0.0;0.0
EX_fru_e;b0724;;fru_e --> ;0.0;0.0
EX_fum_e;b0724;;fum_e --> ;0.0;0.0
EX_glc__D_e;b0724;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b0724;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b0724;;glu__L_e --> ;0.0;0.0
EX_h_e;b0724;;h_e <=> ;17.530865429786523;16.334808001102488
EX_h2o_e;b0724;;h2o_e <=> ;29.175827135565836;31.278831182069318
EX_lac__D_e;b0724;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b0724;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b0724;;nh4_e <=> ;-4.765319193197444;-4.440201449073384
EX_o2_e;b0724;;o2_e <=> ;-21.799492655998886;-24.405753069741035
EX_pi_e;b0724;;pi_e <=> ;-3.214895047684769;-2.995556240959898
EX_pyr_e;b0724;;pyr_e --> ;0.0;0.0
EX_succ_e;b0724;;succ_e --> ;0.0;0.0
FBA;b0724;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;1.566118937490555
FBP;b0724;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b0724;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b0724;;for_c --> for_e;0.0;0.0
FRD7;b0724;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b0724;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b0724;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;0.0
FUMt2_2;b0724;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b0724;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;22.87169799530051
GAPD;b0724;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;10.21145360395944
GLCpts;b0724;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b0724;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.20821587267606811
GLNabc;b0724;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b0724;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.2319855763973155
GLUN;b0724;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b0724;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b0724;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b0724;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;22.871697995300508
H2Ot;b0724;;h2o_e <=> h2o_c;-29.175827135565836;-31.278831182069318
ICDHyr;b0724;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.8785455808768463
ICL;b0724;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b0724;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b0724;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b0724;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b0724;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;0.0
ME1;b0724;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b0724;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b0724;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;48.81150613948207
NADTRHD;b0724;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;31.781369496697486
NH4t;b0724;;nh4_e <=> nh4_c;4.765319193197444;4.440201449073384
O2t;b0724;;o2_e <=> o2_c;21.799492655998886;24.405753069741035
PDH;b0724;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;3.930369779607262
PFK;b0724;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;1.5661189374905553
PFL;b0724;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b0724;;g6p_c <=> f6p_c;4.860861146496871;-13.038628984344676
PGK;b0724;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-10.21145360395944
PGL;b0724;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;22.87169799530051
PGM;b0724;;2pg_c <=> 3pg_c;-14.716139568742859;-8.993264532690771
PIt2r;b0724;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;2.995556240959898
PPC;b0724;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.333450937585219
PPCK;b0724;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b0724;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;3.762888241054585
PTAr;b0724;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b0724;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;0.0
PYRt2;b0724;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b0724;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;14.662481615119287
RPI;b0724;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-8.209216380181223
SUCCt2_2;b0724;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b0724;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b0724;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;0.0
SUCOAS;b0724;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;0.0
TALA;b0724;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;7.478221507669265
THD2;b0724;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b0724;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;7.4782215076692635
TKT2;b0724;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;7.184260107450022
TPI;b0724;;dhap_c <=> g3p_c;7.477381962160304;1.566118937490555
ACALD;b0721;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b0721;;acald_e <=> acald_c;0.0;0.0
ACKr;b0721;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b0721;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;0.8785455808768463
ACONTb;b0721;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;0.8785455808768463
ACt2r;b0721;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b0721;;amp_c + atp_c <=> 2.0 adp_c;0.0;3.762888241054585
AKGDH;b0721;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0
AKGt2r;b0721;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b0721;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b0721;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b0721;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;56.18179161383699
Biomass_Ecoli_core;b0721;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8142975075325308
CO2t;b0721;;co2_e <=> co2_c;-22.809833310205086;-25.347162418199396
CS;b0721;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;0.8785455808768461
CYTBD;b0721;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;48.81150613948208
D_LACt2;b0721;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b0721;;2pg_c <=> h2o_c + pep_c;14.716139568742859;8.993264532690771
ETOHt2r;b0721;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b0721;;ac_e --> ;0.0;0.0
EX_acald_e;b0721;;acald_e --> ;0.0;0.0
EX_akg_e;b0721;;akg_e --> ;0.0;0.0
EX_co2_e;b0721;;co2_e <=> ;22.809833310205086;25.347162418199396
EX_etoh_e;b0721;;etoh_e --> ;0.0;0.0
EX_for_e;b0721;;for_e --> ;0.0;0.0
EX_fru_e;b0721;;fru_e --> ;0.0;0.0
EX_fum_e;b0721;;fum_e --> ;0.0;0.0
EX_glc__D_e;b0721;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b0721;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b0721;;glu__L_e --> ;0.0;0.0
EX_h_e;b0721;;h_e <=> ;17.530865429786523;16.334808001102488
EX_h2o_e;b0721;;h2o_e <=> ;29.175827135565836;31.278831182069318
EX_lac__D_e;b0721;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b0721;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b0721;;nh4_e <=> ;-4.765319193197444;-4.440201449073384
EX_o2_e;b0721;;o2_e <=> ;-21.799492655998886;-24.405753069741035
EX_pi_e;b0721;;pi_e <=> ;-3.214895047684769;-2.995556240959898
EX_pyr_e;b0721;;pyr_e --> ;0.0;0.0
EX_succ_e;b0721;;succ_e --> ;0.0;0.0
FBA;b0721;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;1.566118937490555
FBP;b0721;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b0721;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b0721;;for_c --> for_e;0.0;0.0
FRD7;b0721;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b0721;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b0721;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;0.0
FUMt2_2;b0721;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b0721;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;22.87169799530051
GAPD;b0721;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;10.21145360395944
GLCpts;b0721;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b0721;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.20821587267606811
GLNabc;b0721;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b0721;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.2319855763973155
GLUN;b0721;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b0721;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b0721;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b0721;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;22.871697995300508
H2Ot;b0721;;h2o_e <=> h2o_c;-29.175827135565836;-31.278831182069318
ICDHyr;b0721;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.8785455808768463
ICL;b0721;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b0721;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b0721;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b0721;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b0721;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;0.0
ME1;b0721;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b0721;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b0721;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;48.81150613948207
NADTRHD;b0721;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;31.781369496697486
NH4t;b0721;;nh4_e <=> nh4_c;4.765319193197444;4.440201449073384
O2t;b0721;;o2_e <=> o2_c;21.799492655998886;24.405753069741035
PDH;b0721;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;3.930369779607262
PFK;b0721;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;1.5661189374905553
PFL;b0721;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b0721;;g6p_c <=> f6p_c;4.860861146496871;-13.038628984344676
PGK;b0721;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-10.21145360395944
PGL;b0721;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;22.87169799530051
PGM;b0721;;2pg_c <=> 3pg_c;-14.716139568742859;-8.993264532690771
PIt2r;b0721;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;2.995556240959898
PPC;b0721;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.333450937585219
PPCK;b0721;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b0721;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;3.762888241054585
PTAr;b0721;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b0721;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;0.0
PYRt2;b0721;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b0721;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;14.662481615119287
RPI;b0721;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-8.209216380181223
SUCCt2_2;b0721;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b0721;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b0721;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;0.0
SUCOAS;b0721;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;0.0
TALA;b0721;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;7.478221507669265
THD2;b0721;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b0721;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;7.4782215076692635
TKT2;b0721;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;7.184260107450022
TPI;b0721;;dhap_c <=> g3p_c;7.477381962160304;1.566118937490555
ACALD;b0723;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b0723;;acald_e <=> acald_c;0.0;0.0
ACKr;b0723;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b0723;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;0.8785455808768463
ACONTb;b0723;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;0.8785455808768463
ACt2r;b0723;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b0723;;amp_c + atp_c <=> 2.0 adp_c;0.0;3.762888241054585
AKGDH;b0723;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0
AKGt2r;b0723;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b0723;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b0723;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b0723;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;56.18179161383699
Biomass_Ecoli_core;b0723;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8142975075325308
CO2t;b0723;;co2_e <=> co2_c;-22.809833310205086;-25.347162418199396
CS;b0723;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;0.8785455808768461
CYTBD;b0723;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;48.81150613948208
D_LACt2;b0723;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b0723;;2pg_c <=> h2o_c + pep_c;14.716139568742859;8.993264532690771
ETOHt2r;b0723;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b0723;;ac_e --> ;0.0;0.0
EX_acald_e;b0723;;acald_e --> ;0.0;0.0
EX_akg_e;b0723;;akg_e --> ;0.0;0.0
EX_co2_e;b0723;;co2_e <=> ;22.809833310205086;25.347162418199396
EX_etoh_e;b0723;;etoh_e --> ;0.0;0.0
EX_for_e;b0723;;for_e --> ;0.0;0.0
EX_fru_e;b0723;;fru_e --> ;0.0;0.0
EX_fum_e;b0723;;fum_e --> ;0.0;0.0
EX_glc__D_e;b0723;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b0723;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b0723;;glu__L_e --> ;0.0;0.0
EX_h_e;b0723;;h_e <=> ;17.530865429786523;16.334808001102488
EX_h2o_e;b0723;;h2o_e <=> ;29.175827135565836;31.278831182069318
EX_lac__D_e;b0723;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b0723;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b0723;;nh4_e <=> ;-4.765319193197444;-4.440201449073384
EX_o2_e;b0723;;o2_e <=> ;-21.799492655998886;-24.405753069741035
EX_pi_e;b0723;;pi_e <=> ;-3.214895047684769;-2.995556240959898
EX_pyr_e;b0723;;pyr_e --> ;0.0;0.0
EX_succ_e;b0723;;succ_e --> ;0.0;0.0
FBA;b0723;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;1.566118937490555
FBP;b0723;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b0723;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b0723;;for_c --> for_e;0.0;0.0
FRD7;b0723;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b0723;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b0723;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;0.0
FUMt2_2;b0723;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b0723;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;22.87169799530051
GAPD;b0723;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;10.21145360395944
GLCpts;b0723;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b0723;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.20821587267606811
GLNabc;b0723;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b0723;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.2319855763973155
GLUN;b0723;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b0723;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b0723;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b0723;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;22.871697995300508
H2Ot;b0723;;h2o_e <=> h2o_c;-29.175827135565836;-31.278831182069318
ICDHyr;b0723;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.8785455808768463
ICL;b0723;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b0723;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b0723;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b0723;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b0723;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;0.0
ME1;b0723;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b0723;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b0723;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;48.81150613948207
NADTRHD;b0723;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;31.781369496697486
NH4t;b0723;;nh4_e <=> nh4_c;4.765319193197444;4.440201449073384
O2t;b0723;;o2_e <=> o2_c;21.799492655998886;24.405753069741035
PDH;b0723;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;3.930369779607262
PFK;b0723;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;1.5661189374905553
PFL;b0723;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b0723;;g6p_c <=> f6p_c;4.860861146496871;-13.038628984344676
PGK;b0723;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-10.21145360395944
PGL;b0723;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;22.87169799530051
PGM;b0723;;2pg_c <=> 3pg_c;-14.716139568742859;-8.993264532690771
PIt2r;b0723;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;2.995556240959898
PPC;b0723;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.333450937585219
PPCK;b0723;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b0723;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;3.762888241054585
PTAr;b0723;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b0723;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;0.0
PYRt2;b0723;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b0723;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;14.662481615119287
RPI;b0723;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-8.209216380181223
SUCCt2_2;b0723;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b0723;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b0723;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;0.0
SUCOAS;b0723;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;0.0
TALA;b0723;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;7.478221507669265
THD2;b0723;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b0723;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;7.4782215076692635
TKT2;b0723;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;7.184260107450022
TPI;b0723;;dhap_c <=> g3p_c;7.477381962160304;1.566118937490555
ACALD;b0728;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b0728;;acald_e <=> acald_c;0.0;0.0
ACKr;b0728;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b0728;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;5.836807622090758
ACONTb;b0728;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;5.836807622090757
ACt2r;b0728;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b0728;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b0728;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0
AKGt2r;b0728;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b0728;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b0728;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b0728;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;47.42816442230028
Biomass_Ecoli_core;b0728;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8583074080226886
CO2t;b0728;;co2_e <=> co2_c;-22.809833310205086;-23.474299097890484
CS;b0728;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;5.836807622090757
CYTBD;b0728;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;44.96401980695093
D_LACt2;b0728;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b0728;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.390098435259256
ETOHt2r;b0728;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b0728;;ac_e --> ;0.0;0.0
EX_acald_e;b0728;;acald_e --> ;0.0;0.0
EX_akg_e;b0728;;akg_e --> ;0.0;0.0
EX_co2_e;b0728;;co2_e <=> ;22.809833310205086;23.474299097890484
EX_etoh_e;b0728;;etoh_e --> ;0.0;0.0
EX_for_e;b0728;;for_e --> ;0.0;0.0
EX_fru_e;b0728;;fru_e --> ;0.0;0.0
EX_fum_e;b0728;;fum_e --> ;0.0;0.0
EX_glc__D_e;b0728;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b0728;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b0728;;glu__L_e --> ;0.0;0.0
EX_h_e;b0728;;h_e <=> ;17.530865429786523;17.217646604935172
EX_h2o_e;b0728;;h2o_e <=> ;29.175827135565836;29.726553580890982
EX_lac__D_e;b0728;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b0728;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b0728;;nh4_e <=> ;-4.765319193197444;-4.680178634466116
EX_o2_e;b0728;;o2_e <=> ;-21.799492655998886;-22.48200990347546
EX_pi_e;b0728;;pi_e <=> ;-3.214895047684769;-3.157455461893053
EX_pyr_e;b0728;;pyr_e --> ;0.0;0.0
EX_succ_e;b0728;;succ_e --> ;0.0;0.0
FBA;b0728;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.102006521647742
FBP;b0728;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b0728;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b0728;;for_c --> for_e;0.0;0.0
FRD7;b0728;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b0728;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b0728;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;4.910779759575082
FUMt2_2;b0728;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b0728;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;6.132705298776274
GAPD;b0728;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;15.674126317661198
GLCpts;b0728;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b0728;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.21946920423140145
GLNabc;b0728;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b0728;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.460709430234714
GLUN;b0728;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b0728;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b0728;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b0728;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;6.132705298776272
H2Ot;b0728;;h2o_e <=> h2o_c;-29.175827135565836;-29.726553580890982
ICDHyr;b0728;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.9260278625156759
ICL;b0728;;icit_c --> glx_c + succ_c;0.0;4.910779759575082
LDH_D;b0728;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b0728;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;4.910779759575082
MALt2_2;b0728;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b0728;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;7.3703454680048965
ME1;b0728;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b0728;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;2.4512140511452674
NADH16;b0728;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;40.05324004737584
NADTRHD;b0728;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b0728;;nh4_e <=> nh4_c;4.765319193197444;4.680178634466116
O2t;b0728;;o2_e <=> o2_c;21.799492655998886;22.48200990347546
PDH;b0728;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;13.964351885453269
PFK;b0728;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.102006521647743
PFL;b0728;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b0728;;g6p_c <=> f6p_c;4.860861146496871;3.6913416825790764
PGK;b0728;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-15.674126317661202
PGL;b0728;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;6.132705298776274
PGM;b0728;;2pg_c <=> 3pg_c;-14.716139568742859;-14.390098435259256
PIt2r;b0728;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.157455461893053
PPC;b0728;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;0.0
PPCK;b0728;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b0728;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b0728;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b0728;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;3.9445510597546725
PYRt2;b0728;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b0728;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;3.471518834297473
RPI;b0728;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.6611864644787997
SUCCt2_2;b0728;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b0728;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b0728;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;4.910779759575082
SUCOAS;b0728;;atp_c + coa_c + succ_c --> adp_c + pi_c + succoa_c;-5.064375661482159;0.0
TALA;b0728;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.890683904296832
THD2;b0728;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b0728;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.8906839042968318
TKT2;b0728;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.5808349300006415
TPI;b0728;;dhap_c <=> g3p_c;7.477381962160304;7.102006521647742
ACALD;b0729;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b0729;;acald_e <=> acald_c;0.0;0.0
ACKr;b0729;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b0729;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;5.836807622090764
ACONTb;b0729;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;5.836807622090764
ACt2r;b0729;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b0729;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b0729;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0
AKGt2r;b0729;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b0729;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b0729;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b0729;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;47.42816442230032
Biomass_Ecoli_core;b0729;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.858307408022689
CO2t;b0729;;co2_e <=> co2_c;-22.809833310205086;-23.4742990978905
CS;b0729;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;5.836807622090764
CYTBD;b0729;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;44.964019806950944
D_LACt2;b0729;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b0729;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.390098435259251
ETOHt2r;b0729;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b0729;;ac_e --> ;0.0;0.0
EX_acald_e;b0729;;acald_e --> ;0.0;0.0
EX_akg_e;b0729;;akg_e --> ;0.0;0.0
EX_co2_e;b0729;;co2_e <=> ;22.809833310205086;23.4742990978905
EX_etoh_e;b0729;;etoh_e --> ;0.0;0.0
EX_for_e;b0729;;for_e --> ;0.0;0.0
EX_fru_e;b0729;;fru_e --> ;0.0;0.0
EX_fum_e;b0729;;fum_e --> ;0.0;0.0
EX_glc__D_e;b0729;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b0729;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b0729;;glu__L_e --> ;0.0;0.0
EX_h_e;b0729;;h_e <=> ;17.530865429786523;17.217646604935073
EX_h2o_e;b0729;;h2o_e <=> ;29.175827135565836;29.726553580890982
EX_lac__D_e;b0729;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b0729;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b0729;;nh4_e <=> ;-4.765319193197444;-4.680178634466118
EX_o2_e;b0729;;o2_e <=> ;-21.799492655998886;-22.48200990347547
EX_pi_e;b0729;;pi_e <=> ;-3.214895047684769;-3.1574554618930946
EX_pyr_e;b0729;;pyr_e --> ;0.0;0.0
EX_succ_e;b0729;;succ_e --> ;0.0;0.0
FBA;b0729;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.1020065216477395
FBP;b0729;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b0729;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b0729;;for_c --> for_e;0.0;0.0
FRD7;b0729;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b0729;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b0729;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;4.910779759575085
FUMt2_2;b0729;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b0729;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;6.132705298776282
GAPD;b0729;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;15.674126317661196
GLCpts;b0729;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b0729;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.21946920423140157
GLNabc;b0729;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b0729;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.460709430234716
GLUN;b0729;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b0729;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b0729;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b0729;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;6.132705298776281
H2Ot;b0729;;h2o_e <=> h2o_c;-29.175827135565836;-29.726553580890982
ICDHyr;b0729;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.9260278625156771
ICL;b0729;;icit_c --> glx_c + succ_c;0.0;4.910779759575085
LDH_D;b0729;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b0729;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;4.910779759575085
MALt2_2;b0729;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b0729;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;7.370345468004903
ME1;b0729;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b0729;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;2.4512140511452674
NADH16;b0729;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;40.05324004737586
NADTRHD;b0729;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b0729;;nh4_e <=> nh4_c;4.765319193197444;4.680178634466118
O2t;b0729;;o2_e <=> o2_c;21.799492655998886;22.48200990347547
PDH;b0729;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;13.964351885453283
PFK;b0729;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.1020065216477395
PFL;b0729;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b0729;;g6p_c <=> f6p_c;4.860861146496871;3.6913416825790697
PGK;b0729;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-15.674126317661198
PGL;b0729;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;6.1327052987762825
PGM;b0729;;2pg_c <=> 3pg_c;-14.716139568742859;-14.390098435259251
PIt2r;b0729;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.1574554618930946
PPC;b0729;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;0.0
PPCK;b0729;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b0729;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b0729;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b0729;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;3.9445510597546733
PYRt2;b0729;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b0729;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;3.4715188342974783
RPI;b0729;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.6611864644788032
SUCCt2_2;b0729;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b0729;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b0729;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;4.910779759575085
SUCOAS;b0729;;atp_c + coa_c + succ_c --> adp_c + pi_c + succoa_c;-5.064375661482159;0.0
TALA;b0729;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.8906839042968346
THD2;b0729;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b0729;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.8906839042968344
TKT2;b0729;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.580834930000644
TPI;b0729;;dhap_c <=> g3p_c;7.477381962160304;7.1020065216477395
ACALD;b2464;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b2464;;acald_e <=> acald_c;0.0;0.0
ACKr;b2464;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b2464;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b2464;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350337
ACt2r;b2464;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b2464;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b2464;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.0643756614821
AKGt2r;b2464;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b2464;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b2464;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b2464;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.51400977451749
Biomass_Ecoli_core;b2464;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b2464;;co2_e <=> co2_c;-22.809833310205086;-22.809833310204986
CS;b2464;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350336
CYTBD;b2464;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199756
D_LACt2;b2464;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b2464;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.71613956874283
ETOHt2r;b2464;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b2464;;ac_e --> ;0.0;0.0
EX_acald_e;b2464;;acald_e --> ;0.0;0.0
EX_akg_e;b2464;;akg_e --> ;0.0;0.0
EX_co2_e;b2464;;co2_e <=> ;22.809833310205086;22.809833310204986
EX_etoh_e;b2464;;etoh_e --> ;0.0;0.0
EX_for_e;b2464;;for_e --> ;0.0;0.0
EX_fru_e;b2464;;fru_e --> ;0.0;0.0
EX_fum_e;b2464;;fum_e --> ;0.0;0.0
EX_glc__D_e;b2464;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b2464;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b2464;;glu__L_e --> ;0.0;0.0
EX_h_e;b2464;;h_e <=> ;17.530865429786523;17.530865429786658
EX_h2o_e;b2464;;h2o_e <=> ;29.175827135565836;29.175827135565864
EX_lac__D_e;b2464;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b2464;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b2464;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b2464;;o2_e <=> ;-21.799492655998886;-21.799492655998773
EX_pi_e;b2464;;pi_e <=> ;-3.214895047684769;-3.214895047684795
EX_pyr_e;b2464;;pyr_e --> ;0.0;0.0
EX_succ_e;b2464;;succ_e --> ;0.0;0.0
FBA;b2464;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160283
FBP;b2464;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b2464;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b2464;;for_c --> for_e;0.0;0.0
FRD7;b2464;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b2464;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b2464;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482101
FUMt2_2;b2464;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b2464;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.95998494457466
GAPD;b2464;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167604
GLCpts;b2464;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b2464;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b2464;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b2464;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b2464;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b2464;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b2464;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b2464;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.959984944574659
H2Ot;b2464;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565864
ICDHyr;b2464;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.0072495753503405
ICL;b2464;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b2464;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b2464;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b2464;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b2464;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482099
ME1;b2464;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b2464;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b2464;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.53460965051545
NADTRHD;b2464;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b2464;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b2464;;o2_e <=> o2_c;21.799492655998886;21.799492655998773
PDH;b2464;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b2464;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160284
PFL;b2464;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b2464;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496814
PGK;b2464;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.023526143167608
PGL;b2464;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574659
PGM;b2464;;2pg_c <=> 3pg_c;-14.716139568742859;-14.71613956874283
PIt2r;b2464;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684795
PPC;b2464;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.504309470368732
PPCK;b2464;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b2464;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b2464;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b2464;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067863
PYRt2;b2464;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b2464;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507531
RPI;b2464;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671277
SUCCt2_2;b2464;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b2464;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b2464;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482101
SUCOAS;b2464;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482101
TALA;b2464;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615674
THD2;b2464;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b2464;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615672
TKT2;b2464;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245964
TPI;b2464;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160283
ACALD;b0008;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b0008;;acald_e <=> acald_c;0.0;0.0
ACKr;b0008;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b0008;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b0008;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b0008;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b0008;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b0008;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b0008;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b0008;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b0008;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b0008;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b0008;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b0008;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b0008;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b0008;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b0008;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b0008;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b0008;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b0008;;ac_e --> ;0.0;0.0
EX_acald_e;b0008;;acald_e --> ;0.0;0.0
EX_akg_e;b0008;;akg_e --> ;0.0;0.0
EX_co2_e;b0008;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b0008;;etoh_e --> ;0.0;0.0
EX_for_e;b0008;;for_e --> ;0.0;0.0
EX_fru_e;b0008;;fru_e --> ;0.0;0.0
EX_fum_e;b0008;;fum_e --> ;0.0;0.0
EX_glc__D_e;b0008;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b0008;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b0008;;glu__L_e --> ;0.0;0.0
EX_h_e;b0008;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b0008;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b0008;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b0008;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b0008;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b0008;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b0008;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b0008;;pyr_e --> ;0.0;0.0
EX_succ_e;b0008;;succ_e --> ;0.0;0.0
FBA;b0008;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b0008;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b0008;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b0008;;for_c --> for_e;0.0;0.0
FRD7;b0008;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b0008;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b0008;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b0008;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b0008;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b0008;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b0008;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b0008;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b0008;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b0008;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b0008;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b0008;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b0008;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b0008;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b0008;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b0008;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b0008;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b0008;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b0008;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b0008;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b0008;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b0008;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b0008;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b0008;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b0008;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b0008;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b0008;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b0008;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b0008;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b0008;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b0008;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b0008;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b0008;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b0008;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b0008;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b0008;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b0008;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b0008;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b0008;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b0008;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b0008;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b0008;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b0008;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b0008;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b0008;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b0008;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b0008;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b0008;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b0008;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b0008;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b0008;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b0008;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b2935;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b2935;;acald_e <=> acald_c;0.0;0.0
ACKr;b2935;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b2935;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b2935;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b2935;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b2935;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b2935;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b2935;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b2935;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b2935;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b2935;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b2935;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b2935;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b2935;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b2935;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b2935;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b2935;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b2935;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b2935;;ac_e --> ;0.0;0.0
EX_acald_e;b2935;;acald_e --> ;0.0;0.0
EX_akg_e;b2935;;akg_e --> ;0.0;0.0
EX_co2_e;b2935;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b2935;;etoh_e --> ;0.0;0.0
EX_for_e;b2935;;for_e --> ;0.0;0.0
EX_fru_e;b2935;;fru_e --> ;0.0;0.0
EX_fum_e;b2935;;fum_e --> ;0.0;0.0
EX_glc__D_e;b2935;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b2935;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b2935;;glu__L_e --> ;0.0;0.0
EX_h_e;b2935;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b2935;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b2935;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b2935;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b2935;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b2935;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b2935;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b2935;;pyr_e --> ;0.0;0.0
EX_succ_e;b2935;;succ_e --> ;0.0;0.0
FBA;b2935;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b2935;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b2935;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b2935;;for_c --> for_e;0.0;0.0
FRD7;b2935;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b2935;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b2935;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b2935;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b2935;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b2935;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b2935;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b2935;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b2935;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b2935;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b2935;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b2935;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b2935;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b2935;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b2935;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b2935;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b2935;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b2935;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b2935;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b2935;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b2935;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b2935;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b2935;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b2935;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b2935;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b2935;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b2935;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b2935;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b2935;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b2935;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b2935;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b2935;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b2935;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b2935;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b2935;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b2935;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b2935;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b2935;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b2935;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b2935;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b2935;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b2935;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b2935;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b2935;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b2935;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b2935;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b2935;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b2935;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b2935;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b2935;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b2935;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b2935;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b2465;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b2465;;acald_e <=> acald_c;0.0;0.0
ACKr;b2465;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b2465;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;6.007249575350337
ACONTb;b2465;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;6.007249575350338
ACt2r;b2465;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b2465;;amp_c + atp_c <=> 2.0 adp_c;0.0;0.0
AKGDH;b2465;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;5.064375661482093
AKGt2r;b2465;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b2465;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b2465;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;8.39
ATPS4r;b2465;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;45.514009774517476
Biomass_Ecoli_core;b2465;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.8739215069684305
CO2t;b2465;;co2_e <=> co2_c;-22.809833310205086;-22.80983331020497
CS;b2465;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;6.007249575350337
CYTBD;b2465;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;43.59898531199753
D_LACt2;b2465;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b2465;;2pg_c <=> h2o_c + pep_c;14.716139568742859;14.716139568742836
ETOHt2r;b2465;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b2465;;ac_e --> ;0.0;0.0
EX_acald_e;b2465;;acald_e --> ;0.0;0.0
EX_akg_e;b2465;;akg_e --> ;0.0;0.0
EX_co2_e;b2465;;co2_e <=> ;22.809833310205086;22.80983331020497
EX_etoh_e;b2465;;etoh_e --> ;0.0;0.0
EX_for_e;b2465;;for_e --> ;0.0;0.0
EX_fru_e;b2465;;fru_e --> ;0.0;0.0
EX_fum_e;b2465;;fum_e --> ;0.0;0.0
EX_glc__D_e;b2465;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b2465;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b2465;;glu__L_e --> ;0.0;0.0
EX_h_e;b2465;;h_e <=> ;17.530865429786523;17.530865429786648
EX_h2o_e;b2465;;h2o_e <=> ;29.175827135565836;29.175827135565832
EX_lac__D_e;b2465;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b2465;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b2465;;nh4_e <=> ;-4.765319193197444;-4.765319193197457
EX_o2_e;b2465;;o2_e <=> ;-21.799492655998886;-21.799492655998762
EX_pi_e;b2465;;pi_e <=> ;-3.214895047684769;-3.214895047684796
EX_pyr_e;b2465;;pyr_e --> ;0.0;0.0
EX_succ_e;b2465;;succ_e --> ;0.0;0.0
FBA;b2465;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;7.477381962160286
FBP;b2465;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b2465;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b2465;;for_c --> for_e;0.0;0.0
FRD7;b2465;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b2465;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b2465;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;5.064375661482093
FUMt2_2;b2465;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b2465;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;4.959984944574654
GAPD;b2465;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;16.023526143167608
GLCpts;b2465;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b2465;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.22346172933182762
GLNabc;b2465;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b2465;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-4.54185746386563
GLUN;b2465;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b2465;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b2465;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b2465;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;4.9599849445746536
H2Ot;b2465;;h2o_e <=> h2o_c;-29.175827135565836;-29.175827135565832
ICDHyr;b2465;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;6.007249575350338
ICL;b2465;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b2465;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b2465;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b2465;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b2465;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;5.064375661482093
ME1;b2465;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b2465;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b2465;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;38.534609650515435
NADTRHD;b2465;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;0.0
NH4t;b2465;;nh4_e <=> nh4_c;4.765319193197444;4.765319193197458
O2t;b2465;;o2_e <=> o2_c;21.799492655998886;21.799492655998762
PDH;b2465;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;9.28253259916662
PFK;b2465;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;7.477381962160286
PFL;b2465;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b2465;;g6p_c <=> f6p_c;4.860861146496871;4.860861146496819
PGK;b2465;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-16.02352614316761
PGL;b2465;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;4.959984944574654
PGM;b2465;;2pg_c <=> 3pg_c;-14.716139568742859;-14.716139568742836
PIt2r;b2465;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;3.214895047684796
PPC;b2465;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.5043094703687325
PPCK;b2465;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b2465;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;0.0
PTAr;b2465;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b2465;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;1.7581774441067881
PYRt2;b2465;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b2465;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;2.678481850507527
RPI;b2465;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-2.2815030940671264
SUCCt2_2;b2465;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b2465;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b2465;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;5.064375661482094
SUCOAS;b2465;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.064375661482094
TALA;b2465;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;1.4969837572615654
THD2;b2465;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b2465;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;1.4969837572615654
TKT2;b2465;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;1.181498093245962
TPI;b2465;;dhap_c <=> g3p_c;7.477381962160304;7.477381962160286
ACALD;b3919;;acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c;0.0;0.0
ACALDt;b3919;;acald_e <=> acald_c;0.0;0.0
ACKr;b3919;;ac_c + atp_c <=> actp_c + adp_c;3.1922147150048876e-14;0.0
ACONTa;b3919;;cit_c <=> acon_C_c + h2o_c;6.007249575350396;0.7595854630451013
ACONTb;b3919;;acon_C_c + h2o_c <=> icit_c;6.007249575350396;0.7595854630451014
ACt2r;b3919;;ac_e + h_e <=> ac_c + h_c;3.192214715004888e-14;0.0
ADK1;b3919;;amp_c + atp_c <=> 2.0 adp_c;0.0;4.607428997873811
AKGDH;b3919;;akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c;5.064375661482158;0.0
AKGt2r;b3919;;akg_e + h_e <=> akg_c + h_c;0.0;0.0
ALCD2x;b3919;;etoh_c + nad_c <=> acald_c + h_c + nadh_c;0.0;0.0
ATPM;b3919;;atp_c + h2o_c --> adp_c + h_c + pi_c;8.39;26.210749940156802
ATPS4r;b3919;;adp_c + 4.0 h_e + pi_c <=> atp_c + h2o_c + 3.0 h_c;45.51400977451776;68.8853159013785
Biomass_Ecoli_core;b3919;;1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c;0.8739215069684279;0.7040369478590248
CO2t;b3919;;co2_e <=> co2_c;-22.809833310205086;-30.039355665385333
CS;b3919;;accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c;6.007249575350396;0.7595854630451012
CYTBD;b3919;;2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_e + q8_c;43.59898531199778;58.45083709993102
D_LACt2;b3919;;h_e + lac__D_e <=> h_c + lac__D_c;0.0;0.0
ENO;b3919;;2pg_c <=> h2o_c + pep_c;14.716139568742859;7.775524859544626
ETOHt2r;b3919;;etoh_e + h_e <=> etoh_c + h_c;0.0;0.0
EX_ac_e;b3919;;ac_e --> ;0.0;0.0
EX_acald_e;b3919;;acald_e --> ;0.0;0.0
EX_akg_e;b3919;;akg_e --> ;0.0;0.0
EX_co2_e;b3919;;co2_e <=> ;22.809833310205086;30.039355665385333
EX_etoh_e;b3919;;etoh_e --> ;0.0;0.0
EX_for_e;b3919;;for_e --> ;0.0;0.0
EX_fru_e;b3919;;fru_e --> ;0.0;0.0
EX_fum_e;b3919;;fum_e --> ;0.0;0.0
EX_glc__D_e;b3919;;glc__D_e <=> ;-10.0;-10.0
EX_gln__L_e;b3919;;gln__L_e --> ;0.0;0.0
EX_glu__L_e;b3919;;glu__L_e --> ;0.0;0.0
EX_h_e;b3919;;h_e <=> ;17.530865429786523;14.12298117405203
EX_h2o_e;b3919;;h2o_e <=> ;29.175827135565836;35.16784240836959
EX_lac__D_e;b3919;;lac__D_e --> ;0.0;0.0
EX_mal__L_e;b3919;;mal__L_e --> ;0.0;0.0
EX_nh4_e;b3919;;nh4_e <=> ;-4.765319193197444;-3.838972669285688
EX_o2_e;b3919;;o2_e <=> ;-21.799492655998886;-29.225418549965504
EX_pi_e;b3919;;pi_e <=> ;-3.214895047684769;-2.5899407200890217
EX_pyr_e;b3919;;pyr_e --> ;0.0;0.0
EX_succ_e;b3919;;succ_e --> ;0.0;0.0
FBA;b3919;;fdp_c <=> dhap_c + g3p_c;7.477381962160304;0.0
FBP;b3919;;fdp_c + h2o_c --> f6p_c + pi_c;0.0;0.0
FORt2;b3919;;for_e + h_e --> for_c + h_c;0.0;0.0
FORti;b3919;;for_c --> for_e;0.0;0.0
FRD7;b3919;;fum_c + q8h2_c --> q8_c + succ_c;0.0;0.0
FRUpts2;b3919;;fru_e + pep_c --> f6p_c + pyr_c;0.0;0.0
FUM;b3919;;fum_c + h2o_c <=> mal__L_c;5.064375661482159;1.8194300213456418e-15
FUMt2_2;b3919;;fum_e + 2.0 h_e --> fum_c + 2.0 h_c;0.0;0.0
G6PDH2r;b3919;;g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c;4.959984944574603;27.899083343893903
GAPD;b3919;;g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c;16.023526143167626;8.828764133541728
GLCpts;b3919;;glc__D_e + pep_c --> g6p_c + pyr_c;10.000000000000002;10.000000000000002
GLNS;b3919;;atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c;0.22346172933182715;0.18002224756755264
GLNabc;b3919;;atp_c + gln__L_e + h2o_c --> adp_c + gln__L_c + h_c + pi_c;0.0;0.0
GLUDy;b3919;;glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c;-4.541857463865617;-3.6589504217181372
GLUN;b3919;;gln__L_c + h2o_c --> glu__L_c + nh4_c;0.0;0.0
GLUSy;b3919;;akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c;0.0;0.0
GLUt2r;b3919;;glu__L_e + h_e <=> glu__L_c + h_c;0.0;0.0
GND;b3919;;6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c;4.959984944574602;27.8990833438939
H2Ot;b3919;;h2o_e <=> h2o_c;-29.175827135565836;-35.16784240836959
ICDHyr;b3919;;icit_c + nadp_c <=> akg_c + co2_c + nadph_c;6.007249575350396;0.7595854630451014
ICL;b3919;;icit_c --> glx_c + succ_c;0.0;0.0
LDH_D;b3919;;lac__D_c + nad_c <=> h_c + nadh_c + pyr_c;-2.8851667222789664e-15;0.0
MALS;b3919;;accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c;0.0;0.0
MALt2_2;b3919;;2.0 h_e + mal__L_e --> 2.0 h_c + mal__L_c;0.0;0.0
MDH;b3919;;mal__L_c + nad_c <=> h_c + nadh_c + oaa_c;5.064375661482158;1.8194300213456418e-15
ME1;b3919;;mal__L_c + nad_c --> co2_c + nadh_c + pyr_c;0.0;0.0
ME2;b3919;;mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c;0.0;0.0
NADH16;b3919;;4.0 h_c + nadh_c + q8_c --> 3.0 h_e + nad_c + q8h2_c;38.53460965051561;58.450837099931015
NADTRHD;b3919;;nad_c + nadph_c --> nadh_c + nadp_c;0.0;43.72667877610217
NH4t;b3919;;nh4_e <=> nh4_c;4.765319193197444;3.8389726692856874
O2t;b3919;;o2_e <=> o2_c;21.799492655998886;29.225418549965504
PDH;b3919;;coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c;9.282532599166657;3.3981751362311448
PFK;b3919;;atp_c + f6p_c --> adp_c + fdp_c + h_c;7.477381962160304;-3.3456810303021106e-15
PFL;b3919;;coa_c + pyr_c --> accoa_c + for_c;0.0;0.0
PGI;b3919;;g6p_c <=> f6p_c;4.860861146496871;-18.043410918204998
PGK;b3919;;3pg_c + atp_c <=> 13dpg_c + adp_c;-16.02352614316763;-8.828764133541728
PGL;b3919;;6pgl_c + h2o_c --> 6pgc_c + h_c;4.959984944574602;27.899083343893903
PGM;b3919;;2pg_c <=> 3pg_c;-14.716139568742859;-7.775524859544626
PIt2r;b3919;;h_e + pi_e <=> h_c + pi_c;3.214895047684769;2.5899407200890217
PPC;b3919;;co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c;2.504309470368726;2.017488277784812
PPCK;b3919;;atp_c + oaa_c --> adp_c + co2_c + pep_c;0.0;0.0
PPS;b3919;;atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c;0.0;4.60742899787381
PTAr;b3919;;accoa_c + pi_c <=> actp_c + coa_c;-1.2124702739418495e-14;0.0
PYK;b3919;;adp_c + h_c + pep_c --> atp_c + pyr_c;1.758177444106819;0.0
PYRt2;b3919;;h_e + pyr_e <=> h_c + pyr_c;-7.59778544700626e-16;0.0
RPE;b3919;;ru5p__D_c <=> xu5p__D_c;2.6784818505074948;18.0933271378082
RPI;b3919;;r5p_c <=> ru5p__D_c;-2.2815030940671064;-9.8057562060857
SUCCt2_2;b3919;;2.0 h_e + succ_e --> 2.0 h_c + succ_c;0.0;0.0
SUCCt3;b3919;;h_e + succ_c --> h_c + succ_e;0.0;0.0
SUCDi;b3919;;q8_c + succ_c --> fum_c + q8h2_c;5.064375661482159;1.819430021345642e-15
SUCOAS;b3919;;atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c;-5.064375661482159;-5.68756655051901e-15
TALA;b3919;;g3p_c + s7p_c <=> e4p_c + f6p_c;1.4969837572615485;9.173742237992654
THD2;b3919;;2.0 h_e + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c;0.0;0.0
TKT1;b3919;;r5p_c + xu5p__D_c <=> g3p_c + s7p_c;1.4969837572615483;9.173742237992654
TKT2;b3919;;e4p_c + xu5p__D_c <=> f6p_c + g3p_c;1.1814980932459462;8.919584899815547
TPI;b3919;;dhap_c --> g3p_c;7.477381962160304;0.0