Mercurial > repos > proteore > proteore_build_protein_interaction_maps
view tool-data/Human_bioplex_2019-03-01 @ 5:ba96ca3496a2 draft default tip
"planemo upload commit c9a32e920aae2bc186183611bc0abb2040e106f3"
author | proteore |
---|---|
date | Thu, 06 Feb 2020 08:28:04 -0500 |
parents | 99f6a94c1ade |
children |
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{"convert": {"1": "P04217-2", "10": "P11245", "100": "P00813", "10000": "Q9Y243-2", "10005": "O14734", "10007": "P46926", "100128927": "B2RXF5", "100131755": "Q5H9R4-2", "100132285": "P43631", "100134934": "Q86WV5", "10018": "O43521-12", "10022": "Q9Y5Q6", "10024": "Q12815", "10026": "Q92643", "100271849": "UNKNOWN", "100287932": "O14925", "1003": "P33151", "100423062": "B9A064", "10049": "O75190-3", "100505741": "Q5VX52-2", "100506658": "Q16625", "100507436": "E7EP37", "10052": "P36383", "10053": "Q9Y6Q5-2", "10054": "Q9UBT2", "1006": "A8MUN9", "10061": "Q9UG63", "10062": "Q13133-2", "10069": "P57060", "10073": "O95149", "10076": "Q92729-2", "10078": "Q9Y5U2-2", "10085": "O43854-2", "10087": "Q9Y5P4-2", "10090": "Q9Y2C2", "10092": "O15511-2", "10094": "O15145", "10095": "O15143", "10096": "P61158", "10098": "P62079", "10099": "O60637", "10100": "O60636", "10102": "P43897", "10106": "O14595", "10107": "Q9UDY6-2", "1012": "P55290", "10120": "P42025", "10123": "P56559", "10127": "O14978", "10130": "Q15084-2", "10133": "Q96CV9-2", "10136": "P09093", "10138": "Q8IY57", "10140": "P50616", "10141": "UNKNOWN", "10142": "Q99996-2", "10143": "O75596", "10144": "O94988-1", "10150": "Q5VZF2-2", "10152": "Q9NYB9-2", "10155": "Q13263-2", "10159": "O75787", "10161": "P43657", "10165": "Q9UJS0", "10166": "Q9Y619", "1017": "P24941", "10170": "Q9BPW9", "10179": "Q9Y580", "1018": "Q00526", "10188": "Q07912-2", "1019": "P11802", "10190": "O14530", "10195": "Q92685", "10197": "P61289-2", "1020": "Q00535", "10202": "Q13268", "10206": "O60858-3", "1021": "Q00534", "10212": "O00148", "10214": "Q99909", "10218": "O43827", "1022": "P50613", "10221": "Q96RU8", "10225": "Q8WUE2", "10226": "O60664-3", "10228": "O43752", "10231": "Q14206-2", "10236": "O43390-2", "10238": "P61962", "1024": "P49336-2", "10240": "Q92665", "10241": "Q13137", "10246": "O00624-2", "10247": "P52758", "1025": "P50750-2", "10253": "O43597", "10256": "UNKNOWN", "10261": "O95976", "10281": "P56555", "10291": 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"FAM101B", "0.882580732923398"]], "Q9Y6Q5-2": [["Q9Y6Q5-2", "Q6ULP2-2", "AP1M2", "AFTPH", "0.979089550306346"]], "Q9Y6W6": [["Q9Y6W6", "Q9BUP0", "DUSP10", "EFHD1", "0.905294448233926"]], "Q9Y6W8-2": [["Q9Y6W8-2", "O75144-2", "ICOS", "ICOSLG", "0.999998263265186"]], "Q9Y6X3": [["Q9Y6X3", "Q70IA8", "MAU2", "MOBKL2C", "0.963367703588323"]], "Q9Y6Z7": [["Q9Y6Z7", "Q8IU60-2", "COLEC10", "DCP2", "0.995120427033237"]], "UNKNOWN": [["UNKNOWN", "Q86XL3", "OSMR", "ANKLE2", "0.940157215249329"]], "UniprotA": [["UniprotA", "UniprotB", "SymbolA", "SymbolB", "p(Interaction)"]]}}, "nodes": {"GeneID": {"1": ["Platelet degranulation ", "Neutrophil degranulation"], "10": ["Acetylation"], "100": ["Purine salvage"], "1000": ["CDO in myogenesis", "CDO in myogenesis", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Adherens junctions interactions", "Post-translational protein phosphorylation"], "10000": ["Activation of BAD and translocation to mitochondria ", "PIP3 activates AKT signaling", "PIP3 activates AKT signaling", "Downregulation of ERBB2:ERBB3 signaling", "AKT phosphorylates targets in the cytosol", "AKT phosphorylates targets in the cytosol", "AKT phosphorylates targets in the nucleus", "Negative regulation of the PI3K/AKT network", "AKT-mediated inactivation of FOXO1A", "CD28 dependent PI3K/Akt signaling", "CTLA4 inhibitory signaling", "G beta:gamma signalling through PI3Kgamma", "VEGFR2 mediated vascular permeability", "TP53 Regulates Metabolic Genes", "Constitutive Signaling by AKT1 E17K in Cancer", "Regulation of TP53 Degradation", "Regulation of TP53 Activity through Acetylation", "Regulation of TP53 Activity through Association with Co-factors", "Cyclin E associated events during G1/S transition ", "Cyclin A:Cdk2-associated events at S phase entry", "RAB GEFs exchange GTP for GDP on RABs", "RUNX2 regulates genes involved in cell migration", "Regulation of PTEN stability and activity", "Regulation of localization of FOXO transcription factors"], "10001": ["PPARA activates gene expression", "Generic Transcription Pathway", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "10002": ["Nuclear Receptor transcription pathway"], "10003": ["Amino acid synthesis and interconversion (transamination)"], "100049587": ["DAP12 interactions", "Neutrophil degranulation"], "10005": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "alpha-linolenic acid (ALA) metabolism", "Beta-oxidation of pristanoyl-CoA", "Beta-oxidation of very long chain fatty acids", "Peroxisomal protein import", "Peroxisomal protein import"], "10006": ["Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs"], "10007": ["Glycolysis"], "10008": ["Phase 3 - rapid repolarisation", "Phase 2 - plateau phase"], "1001": ["Adherens junctions interactions"], "10010": ["TICAM1-dependent activation of IRF3/IRF7", "TRAF6 mediated IRF7 activation", "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon"], "100129543": ["Generic Transcription Pathway"], "100129669": ["Sperm:Oocyte Membrane Binding"], "100129842": ["Generic Transcription Pathway"], "10013": ["NOTCH1 Intracellular Domain Regulates Transcription", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "HSF1 activation", "Cilium Assembly", "Transcriptional regulation by RUNX2", "RUNX2 regulates osteoblast differentiation"], "100131187": ["Sulfide oxidation to sulfate"], "100131439": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "100131539": ["Generic Transcription Pathway"], "100131902": ["Keratinization"], "100131980": ["Generic Transcription Pathway"], "100132285": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "DAP12 interactions"], "100132386": ["Keratinization"], "100133267": ["Beta defensins", "Defensins"], "100133941": ["L1CAM interactions"], "100137049": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PS", "Acyl chain remodelling of PE", "Acyl chain remodelling of PG", "Hydrolysis of LPC", "Synthesis of PA", "XBP1(S) activates chaperone genes"], "10014": ["NOTCH1 Intracellular Domain Regulates Transcription", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "Regulation of PTEN gene transcription"], "10015": ["Budding and maturation of HIV virion", "Uptake and function of anthrax toxins"], "10018": ["Activation of BIM and translocation to mitochondria ", "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "NRAGE signals death through JNK", "Signaling by BRAF and RAF fusions", "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "RUNX3 regulates BCL2L11 (BIM) transcription", "FOXO-mediated transcription of cell death genes"], "100188893": ["Mitochondrial protein import", "Pink/Parkin Mediated Mitophagy"], "10019": ["Regulation of KIT signaling", "Factors involved in megakaryocyte development and platelet production"], "1002": ["CDO in myogenesis", "CDO in myogenesis", "Adherens junctions interactions"], "10020": ["Sialic acid metabolism", "Defective GNE causes sialuria, Nonaka myopathy and inclusion body myopathy 2"], "10021": ["HCN channels"], "10022": ["G alpha (i) signalling events", "Relaxin receptors"], "10023": ["Beta-catenin phosphorylation cascade", "Disassembly of the destruction complex and recruitment of AXIN to the membrane"], "10025": ["PPARA activates gene expression", "Generic Transcription Pathway", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "10026": ["Attachment of GPI anchor to uPAR"], "100271715": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "100271849": ["CDO in myogenesis"], "100272147": ["Mitochondrial protein import"], "100287144": ["Ub-specific processing proteases"], "100287178": ["Ub-specific processing proteases"], "100287205": ["Ub-specific processing proteases"], "100287226": ["Generic Transcription Pathway"], "100287238": ["Ub-specific processing proteases"], "100287327": ["Ub-specific processing proteases"], "100287364": ["Ub-specific processing proteases"], "100287404": ["Ub-specific processing proteases"], "100287441": ["Ub-specific processing proteases"], "100287478": ["Ub-specific processing proteases"], "100287513": ["Ub-specific processing proteases"], "100287932": ["Mitochondrial protein import", "Mitochondrial protein import"], "100288323": ["Keratinization"], "100289462": ["Beta defensins", "Defensins"], "100289635": ["Generic Transcription Pathway"], "100293534": ["Initial triggering of complement", "Activation of C3 and C5", "Regulation of Complement cascade"], "1003": ["Adherens junctions interactions", "VEGFR2 mediated vascular permeability"], "100302652": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "100302736": ["Caspase activation via Death Receptors in the presence of ligand", "Toll Like Receptor 4 (TLR4) Cascade", "MyD88-independent TLR4 cascade ", "TRIF-mediated programmed cell death", "Neutrophil degranulation", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon", "IKK complex recruitment mediated by RIP1", "TRAF6-mediated induction of TAK1 complex within TLR4 complex", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"], "10038": ["POLB-Dependent Long Patch Base Excision Repair", "HDR through MMEJ (alt-NHEJ)", "DNA Damage Recognition in GG-NER", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER"], "1004": ["Adherens junctions interactions"], "10043": ["Neutrophil degranulation"], "10046": ["Pre-NOTCH Transcription and Translation", "Pre-NOTCH Transcription and Translation", "Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "NOTCH1 Intracellular Domain Regulates Transcription", "NOTCH1 Intracellular Domain Regulates Transcription", "NOTCH2 intracellular domain regulates transcription", "NOTCH2 intracellular domain regulates transcription", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "Notch-HLH transcription pathway", "RUNX3 regulates NOTCH signaling", "RUNX3 regulates NOTCH signaling", "NOTCH3 Intracellular Domain Regulates Transcription", "NOTCH3 Intracellular Domain Regulates Transcription", "NOTCH4 Intracellular Domain Regulates Transcription", "NOTCH4 Intracellular Domain Regulates Transcription"], "10048": ["L1CAM interactions", "RAF/MAP kinase cascade", "MET activates RAS signaling"], "10049": ["Regulation of HSF1-mediated heat shock response"], "1005": ["Adherens junctions interactions"], "100505724": ["Keratinization"], "100505753": ["Keratinization"], "100506658": ["Apoptotic cleavage of cell adhesion proteins", "RUNX1 regulates expression of components of tight junctions"], "100506888": ["Formation of RNA Pol II elongation complex ", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "RNA Polymerase II Transcription Elongation"], "100507436": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "100507608": ["Keratinization"], "10051": ["Condensation of Prophase Chromosomes", "Condensation of Prometaphase Chromosomes", "Condensation of Prometaphase Chromosomes"], "10052": ["Electric Transmission Across Gap Junctions", "Gap junction assembly"], "100526737": ["RUNX2 regulates bone development"], "100526739": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Deposition of new CENPA-containing nucleosomes at the centromere", "Fanconi Anemia Pathway", "Mitotic Prometaphase"], "100526767": ["Budding and maturation of HIV virion", "Macroautophagy", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "100526773": ["Antimicrobial peptides"], "100526794": ["Purine catabolism"], "100527963": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "100528030": ["O-linked glycosylation of mucins"], "100528032": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "DAP12 interactions", "DAP12 signaling", "DAP12 signaling"], "100529261": ["Inactivation, recovery and regulation of the phototransduction cascade"], "10053": ["Nef mediated downregulation of MHC class I complex cell surface expression", "MHC class II antigen presentation", "Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis"], "100532731": ["Oxidative Stress Induced Senescence", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of transcription cofactors", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA methylation proteins", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription", "Transcriptional Regulation by E2F6"], "100533105": ["Stimuli-sensing channels"], "100533177": ["Keratinization"], "100534599": ["Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "mRNA Splicing - Major Pathway"], "10054": ["SUMO is conjugated to E1 (UBA2:SAE1)", "SUMO is conjugated to E1 (UBA2:SAE1)", "SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "SUMO is transferred from E1 to E2 (UBE2I, UBC9)"], "10055": ["SUMO is conjugated to E1 (UBA2:SAE1)", "SUMO is conjugated to E1 (UBA2:SAE1)", "SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "SUMO is transferred from E1 to E2 (UBE2I, UBC9)"], "10056": ["Cytosolic tRNA aminoacylation"], "10057": ["Hyaluronan biosynthesis and export", "ABC-family proteins mediated transport"], "10058": ["Mitochondrial ABC transporters", "Defective ABCB6 causes isolated colobomatous microphthalmia 7 (MCOPCB7)"], "10059": ["Apoptotic execution phase"], "1006": ["Adherens junctions interactions"], "10060": ["ATP sensitive Potassium channels", "ABC-family proteins mediated transport", "Ion homeostasis", "Defective ABCC9 causes dilated cardiomyopathy 10, familial atrial fibrillation 12 and hypertrichotic osteochondrodysplasia"], "10062": ["PPARA activates gene expression", "Nuclear Receptor transcription pathway", "SUMOylation of intracellular receptors", "VLDLR internalisation and degradation"], "10063": ["Mitochondrial protein import"], "100653049": ["Keratinization", "Formation of the cornified envelope"], "10068": ["Interleukin-37 signaling", "Interleukin-18 signaling"], "1007": ["Adherens junctions interactions"], "10071": ["Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)", "Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)", "Defective GALNT12 causes colorectal cancer 1 (CRCS1)", "Dectin-2 family", "O-linked glycosylation of mucins", "Termination of O-glycan biosynthesis"], "10073": ["snRNP Assembly"], "10075": ["Neutrophil degranulation", "Antigen processing: Ubiquitination & Proteasome degradation"], "10076": ["Signaling by SCF-KIT"], "10079": ["Ion transport by P-type ATPases"], "1008": ["Adherens junctions interactions"], "10081": ["mRNA Splicing - Minor Pathway"], "10082": ["A tetrasaccharide linker sequence is required for GAG synthesis", "HS-GAG biosynthesis", "HS-GAG biosynthesis", "HS-GAG degradation", "Defective B4GALT7 causes EDS, progeroid type", "Defective B3GAT3 causes JDSSDHD", "Defective EXT2 causes exostoses 2", "Defective EXT1 causes exostoses 1, TRPS2 and CHDS", "Defective B3GALT6 causes EDSP2 and SEMDJL1", "Retinoid metabolism and transport"], "10084": ["mRNA Splicing - Major Pathway"], "100861532": ["NoRC negatively regulates rRNA expression", "rRNA modification in the nucleus and cytosol", "rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol", "RNA Polymerase I Transcription Termination"], "100861540": ["Xenobiotics"], "10087": ["Sphingolipid de novo biosynthesis"], "10089": ["Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)", "Phase 4 - resting membrane potential"], "1009": ["Adherens junctions interactions"], "10090": ["Dermatan sulfate biosynthesis"], "100913187": ["mRNA Editing: C to U Conversion", "Formation of the Editosome"], "10092": ["Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "EPHB-mediated forward signaling", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs", "Neutrophil degranulation", "Clathrin-mediated endocytosis"], "10093": ["Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "EPHB-mediated forward signaling", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs", "Clathrin-mediated endocytosis"], "10094": ["Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "EPHB-mediated forward signaling", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs", "Clathrin-mediated endocytosis"], "10095": ["Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "EPHB-mediated forward signaling", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs"], "10096": ["Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "EPHB-mediated forward signaling", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs", "Clathrin-mediated endocytosis"], "10097": ["Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "EPHB-mediated forward signaling", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs", "Neutrophil degranulation", "Clathrin-mediated endocytosis"], "10098": ["Amyloid fiber formation"], "100996750": ["Keratinization"], "100996758": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "101": ["Degradation of the extracellular matrix", "Neutrophil degranulation"], "1010": ["Adherens junctions interactions"], "10101": ["Cytosolic iron-sulfur cluster assembly"], "10102": ["Mitochondrial translation elongation"], "10106": ["XBP1(S) activates chaperone genes"], "101060233": ["The retinoid cycle in cones (daylight vision)", "Retinoid cycle disease events", "G alpha (i) signalling events", "Opsins"], "10107": ["Interferon gamma signaling"], "10109": ["Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "EPHB-mediated forward signaling", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs", "Clathrin-mediated endocytosis"], "10110": ["Stimuli-sensing channels"], "10111": ["DNA Damage/Telomere Stress Induced Senescence", "HDR through Single Strand Annealing (SSA)", "HDR through MMEJ (alt-NHEJ)", "HDR through Homologous Recombination (HRR)", "Sensing of DNA Double Strand Breaks", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Nonhomologous End-Joining (NHEJ)", "Homologous DNA Pairing and Strand Exchange", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Regulation of TP53 Activity through Phosphorylation", "G2/M DNA damage checkpoint", "Meiotic recombination"], "10112": ["MHC class II antigen presentation", "COPI-dependent Golgi-to-ER retrograde traffic", "Mitotic Telophase/Cytokinesis", "Kinesins"], "10113": ["COPII-mediated vesicle transport", "XBP1(S) activates chaperone genes", "Cargo concentration in the ER"], "10116": ["Neddylation"], "10117": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "1012": ["Adherens junctions interactions"], "10120": ["MHC class II antigen presentation", "Neutrophil degranulation"], "10121": ["MHC class II antigen presentation", "Regulation of PLK1 Activity at G2/M Transition", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic", "AURKA Activation by TPX2"], "10125": ["Effects of PIP2 hydrolysis", "Activation of RAS in B cells", "Activation of RAS in B cells", "FCERI mediated NF-kB activation", "Integrin alphaIIb beta3 signaling", "Rap1 signalling", "RAF/MAP kinase cascade"], "10126": ["Retrograde neurotrophin signalling"], "10127": ["Generic Transcription Pathway"], "10128": ["TP53 Regulates Metabolic Genes", "Respiratory electron transport"], "1013": ["CDO in myogenesis", "CDO in myogenesis", "Adherens junctions interactions"], "10130": ["XBP1(S) activates chaperone genes", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "10131": ["Respiratory electron transport"], "10133": ["Regulation of PLK1 Activity at G2/M Transition", "TBC/RABGAPs"], "10134": ["Apoptotic cleavage of cellular proteins", "Apoptotic execution phase", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "10135": ["BMAL1:CLOCK,NPAS2 activates circadian gene expression", "Nicotinamide salvaging"], "10138": ["RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Transcriptional Regulation by E2F6"], "10139": ["Retrograde transport at the Trans-Golgi-Network", "Retrograde transport at the Trans-Golgi-Network"], "10142": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Phase 3 - rapid repolarisation", "Phase 2 - plateau phase", "Anchoring of the basal body to the plasma membrane", "Signaling by BRAF and RAF fusions", "AURKA Activation by TPX2"], "10144": ["Rho GTPase cycle"], "10148": ["Interleukin-35 Signalling", "Interleukin-27 signaling"], "1015": ["Adherens junctions interactions"], "10152": ["Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs"], "10154": ["Other semaphorin interactions"], "10155": ["Generic Transcription Pathway", "SUMOylation of transcription cofactors"], "10156": ["Regulation of RAS by GAPs", "Signaling by RAS mutants"], "10157": ["Lysine catabolism"], "10159": ["Metabolism of Angiotensinogen to Angiotensins", "Neutrophil degranulation"], "1016": ["Adherens junctions interactions"], "10161": ["G alpha (q) signalling events", "P2Y receptors"], "10162": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PS", "Acyl chain remodelling of PE"], "10163": ["Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs"], "10164": ["O-linked glycosylation of mucins"], "10165": ["Mitochondrial protein import", "Gluconeogenesis"], "10166": ["Urea cycle"], "10168": ["Generic Transcription Pathway"], "1017": ["G0 and Early G1", "Activation of ATR in response to replication stress", "Regulation of APC/C activators between G1/S and early anaphase", "SCF(Skp2)-mediated degradation of p27/p21", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "Processing of DNA double-strand break ends", "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "Regulation of TP53 Activity through Phosphorylation", "Regulation of TP53 Degradation", "G2 Phase", "Orc1 removal from chromatin", "Activation of the pre-replicative complex", "CDK-mediated phosphorylation and removal of Cdc6", "Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes", "Cyclin E associated events during G1/S transition ", "Cyclin A/B1/B2 associated events during G2/M transition", "p53-Dependent G1 DNA Damage Response", "Cyclin A:Cdk2-associated events at S phase entry", "PTK6 Regulates Cell Cycle", "Meiotic recombination", "Factors involved in megakaryocyte development and platelet production"], "10170": ["The canonical retinoid cycle in rods (twilight vision)", "RA biosynthesis pathway"], "10171": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "10172": ["Generic Transcription Pathway"], "10174": ["Smooth Muscle Contraction"], "10175": ["COPII-mediated vesicle transport", "Cargo concentration in the ER"], "10181": ["mRNA Splicing - Major Pathway"], "10184": ["Platelet degranulation "], "10189": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing"], "1019": ["SCF(Skp2)-mediated degradation of p27/p21", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "Oncogene Induced Senescence", "RMTs methylate histone arginines", "Transcriptional regulation of white adipocyte differentiation", "Ubiquitin-dependent degradation of Cyclin D1", "Ubiquitin-dependent degradation of Cyclin D1", "Cyclin D associated events in G1", "PTK6 Regulates Cell Cycle", "Transcriptional regulation by RUNX2", "Meiotic recombination"], "10193": ["Downregulation of ERBB2:ERBB3 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "10195": ["Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "Defective ALG3 causes ALG3-CDG (CDG-1d)"], "10196": ["RMTs methylate histone arginines", "Protein methylation"], "10197": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "10199": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "102": ["Collagen degradation", "Degradation of the extracellular matrix", "Signaling by EGFR", "Activated NOTCH1 Transmits Signal to the Nucleus", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant", "Constitutive Signaling by NOTCH1 HD Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "NOTCH2 Activation and Transmission of Signal to the Nucleus", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "EPH-ephrin mediated repulsion of cells", "Neutrophil degranulation", "Post-translational protein phosphorylation", "NOTCH3 Activation and Transmission of Signal to the Nucleus", "NOTCH4 Activation and Transmission of Signal to the Nucleus", "Amyloid fiber formation"], "1020": ["DARPP-32 events", "CRMPs in Sema3A signaling", "CRMPs in Sema3A signaling", "Regulation of TP53 Activity through Phosphorylation", "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "Activated NTRK2 signals through CDK5", "Factors involved in megakaryocyte development and platelet production"], "10200": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "10203": ["G alpha (s) signalling events", "Calcitonin-like ligand receptors"], "10206": ["ER Quality Control Compartment (ERQC)"], "1021": ["Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "Oncogene Induced Senescence", "Cyclin D associated events in G1", "Regulation of RUNX1 Expression and Activity"], "10210": ["SUMOylation of transcription cofactors", "SUMOylation of SUMOylation proteins", "SUMOylation of immune response proteins"], "10211": ["Synaptic adhesion-like molecules"], "10212": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA 3'-end processing"], "10213": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "Metalloprotease DUBs", "Neutrophil degranulation", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "102157402": ["Interconversion of nucleotide di- and triphosphates"], "10219": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "1022": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Tat-mediated elongation of the HIV-1 transcript", "NoRC negatively regulates rRNA expression", "Formation of Incision Complex in GG-NER", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "Cyclin E associated events during G1/S transition ", "Cyclin D associated events in G1", "Cyclin A/B1/B2 associated events during G2/M transition", "Cyclin A:Cdk2-associated events at S phase entry", "mRNA Capping", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase I Transcription Termination", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE", "RUNX1 regulates transcription of genes involved in differentiation of HSCs"], "10224": ["Generic Transcription Pathway"], "10225": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "10226": ["Triglyceride catabolism", "Retrograde transport at the Trans-Golgi-Network"], "10228": ["Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network"], "10229": ["Ubiquinol biosynthesis"], "10232": ["Post-translational modification: synthesis of GPI-anchored proteins", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "10235": ["Effects of PIP2 hydrolysis", "FCERI mediated NF-kB activation", "Integrin alphaIIb beta3 signaling", "Rap1 signalling"], "10236": ["mRNA Splicing - Major Pathway", "Processing of Capped Intron-Containing Pre-mRNA"], "10238": ["Association of TriC/CCT with target proteins during biosynthesis", "Neddylation"], "1024": ["PPARA activates gene expression", "NOTCH1 Intracellular Domain Regulates Transcription", "Generic Transcription Pathway", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "10240": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "10242": ["Ca2+ activated K+ channels", "cGMP effects"], "10243": ["Molybdenum cofactor biosynthesis"], "10244": ["Retrograde transport at the Trans-Golgi-Network"], "10245": ["Mitochondrial protein import", "Mitochondrial protein import"], "10247": ["Threonine catabolism"], "10248": ["tRNA processing in the nucleus"], "10249": ["Conjugation of salicylate with glycine", "Conjugation of benzoate with glycine"], "1025": ["Formation of RNA Pol II elongation complex ", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "Interactions of Tat with host cellular proteins", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Transcription Elongation", "Estrogen-dependent gene expression"], "10250": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing"], "10252": ["EGFR downregulation"], "10253": ["Spry regulation of FGF signaling", "EGFR downregulation"], "10254": ["EGFR downregulation", "Ub-specific processing proteases", "Negative regulation of MET activity", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "InlB-mediated entry of Listeria monocytogenes into host cell", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "10256": ["MAP2K and MAPK activation", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF"], "10257": ["Platelet degranulation ", "ABC-family proteins mediated transport"], "1026": ["SCF(Skp2)-mediated degradation of p27/p21", "AKT phosphorylates targets in the cytosol", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "Constitutive Signaling by AKT1 E17K in Cancer", "Interleukin-4 and Interleukin-13 signaling", "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "Cyclin E associated events during G1/S transition ", "Cyclin D associated events in G1", "p53-Dependent G1 DNA Damage Response", "Cyclin A:Cdk2-associated events at S phase entry", "Transcriptional activation of cell cycle inhibitor p21 ", "The role of GTSE1 in G2/M progression after G2 checkpoint", "TFAP2 (AP-2) family regulates transcription of cell cycle factors", "Transcriptional regulation by RUNX2", "RUNX3 regulates CDKN1A transcription", "FOXO-mediated transcription of cell cycle genes"], "10260": ["RAB GEFs exchange GTP for GDP on RABs"], "10262": ["mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "10266": ["G alpha (s) signalling events", "Calcitonin-like ligand receptors"], "10267": ["G alpha (s) signalling events", "Calcitonin-like ligand receptors"], "10268": ["G alpha (s) signalling events", "Calcitonin-like ligand receptors"], "1027": ["SCF(Skp2)-mediated degradation of p27/p21", "AKT phosphorylates targets in the cytosol", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "RHO GTPases activate CIT", "Constitutive Signaling by AKT1 E17K in Cancer", "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "Cyclin E associated events during G1/S transition ", "Cyclin D associated events in G1", "p53-Dependent G1 DNA Damage Response", "Cyclin A:Cdk2-associated events at S phase entry", "PTK6 Regulates Cell Cycle", "FOXO-mediated transcription of cell cycle genes"], "10272": ["Antagonism of Activin by Follistatin", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "102723532": ["Olfactory Signaling Pathway"], "102723996": ["Costimulation by the CD28 family"], "102724159": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "102724334": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "102724428": ["Circadian Clock"], "102724560": ["Cysteine formation from homocysteine", "Metabolism of ingested SeMet, Sec, MeSec into H2Se"], "102724594": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing"], "102725035": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation"], "10273": ["Downregulation of TGF-beta receptor signaling", "Downregulation of ERBB2 signaling", "Regulation of RUNX2 expression and activity", "Regulation of PTEN stability and activity", "Antigen processing: Ubiquitination & Proteasome degradation"], "10274": ["Meiotic synapsis", "Separation of Sister Chromatids", "Establishment of Sister Chromatid Cohesion", "Cohesin Loading onto Chromatin", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA damage response and repair proteins", "Estrogen-dependent gene expression"], "10276": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "1028": ["Cyclin D associated events in G1"], "102800317": ["WNT mediated activation of DVL", "Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Circadian Clock", "Anchoring of the basal body to the plasma membrane", "Major pathway of rRNA processing in the nucleolus and cytosol", "AURKA Activation by TPX2"], "10282": ["COPII-mediated vesicle transport", "COPI-mediated anterograde transport"], "10283": ["mRNA Splicing - Major Pathway"], "10284": ["HDACs deacetylate histones", "NoRC negatively regulates rRNA expression"], "10285": ["mRNA Splicing - Major Pathway"], "10286": ["mRNA Splicing - Major Pathway"], "10287": ["G alpha (q) signalling events", "G alpha (i) signalling events", "G alpha (i) signalling events", "G alpha (z) signalling events"], "1029": ["Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "Oncogene Induced Senescence", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of transcription factors", "Regulation of TP53 Degradation", "Cyclin D associated events in G1", "Stabilization of p53", "Regulation of RUNX3 expression and activity"], "10291": ["mRNA Splicing - Major Pathway"], "10293": ["Antigen processing: Ubiquitination & Proteasome degradation"], "10294": ["HSP90 chaperone cycle for steroid hormone receptors (SHR)"], "10295": ["Branched-chain amino acid catabolism"], "10298": ["Activation of RAC1"], "10299": ["ER Quality Control Compartment (ERQC)"], "103": ["C6 deamination of adenosine", "Formation of editosomes by ADAR proteins", "Interferon alpha/beta signaling"], "1030": ["SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "Oncogene Induced Senescence", "Cyclin D associated events in G1"], "10302": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "10308": ["Generic Transcription Pathway"], "1031": ["Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "Oncogene Induced Senescence", "Cyclin D associated events in G1"], "10312": ["ROS, RNS production in phagocytes", "Neutrophil degranulation", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "10313": ["Synaptic adhesion-like molecules"], "10316": ["Peptide ligand-binding receptors", "G alpha (q) signalling events", "G alpha (i) signalling events"], "10318": ["Ovarian tumor domain proteases"], "10319": ["Laminin interactions", "Laminin interactions", "Non-integrin membrane-ECM interactions", "MET activates PTK2 signaling"], "1032": ["Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "Oncogene Induced Senescence", "Cyclin D associated events in G1"], "10320": ["NOTCH3 Intracellular Domain Regulates Transcription"], "10321": ["Neutrophil degranulation"], "10324": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "10325": ["Macroautophagy", "mTOR signalling", "mTORC1-mediated signalling", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Regulation of PTEN gene transcription"], "10326": ["DAP12 interactions", "Signal regulatory protein family interactions", "Neutrophil degranulation"], "10327": ["Glutathione conjugation", "Formation of xylulose-5-phosphate"], "10331": ["Keratan sulfate biosynthesis", "O-linked glycosylation of mucins"], "10333": ["ER-Phagosome pathway", "MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "Toll Like Receptor TLR6:TLR2 Cascade", "MyD88 deficiency (TLR2/4)", "IRAK4 deficiency (TLR2/4)", "Regulation of TLR by endogenous ligand"], "10335": ["cGMP effects"], "10342": ["COPII-mediated vesicle transport"], "10345": ["Stimuli-sensing channels", "Ion homeostasis"], "10346": ["Interferon gamma signaling"], "10347": ["ABC transporters in lipid homeostasis"], "10349": ["ABC transporters in lipid homeostasis"], "10350": ["ABC transporters in lipid homeostasis"], "10351": ["ABC-family proteins mediated transport"], "10352": ["Mitochondrial tRNA aminoacylation"], "1036": ["Degradation of cysteine and homocysteine"], "10362": ["HDACs deacetylate histones", "Factors involved in megakaryocyte development and platelet production"], "10367": ["Mitochondrial calcium ion transport", "Processing of SMDT1"], "10368": ["Trafficking of AMPA receptors", "Phase 0 - rapid depolarisation", "Phase 2 - plateau phase", "LGI-ADAM interactions"], "10369": ["Presynaptic depolarization and calcium channel opening", "Trafficking of AMPA receptors", "Phase 0 - rapid depolarisation", "Phase 2 - plateau phase", "LGI-ADAM interactions"], "10370": ["Regulation of gene expression by Hypoxia-inducible Factor", "TFAP2 (AP-2) family regulates transcription of other transcription factors", "Activation of the TFAP2 (AP-2) family of transcription factors", "FOXO-mediated transcription of cell death genes"], "10371": ["Sema3A PAK dependent Axon repulsion", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "CRMPs in Sema3A signaling", "CRMPs in Sema3A signaling"], "10376": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "Gap junction assembly", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Recruitment of NuMA to mitotic centrosomes", "Formation of tubulin folding intermediates by CCT/TriC", "Post-chaperonin tubulin folding pathway", "Recycling pathway of L1", "Recycling pathway of L1", "Hedgehog 'off' state", "Cilium Assembly", "Intraflagellar transport", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "Carboxyterminal post-translational modifications of tubulin", "Carboxyterminal post-translational modifications of tubulin", "Activation of AMPK downstream of NMDARs", "Kinesins"], "10379": ["Interferon gamma signaling", "Interferon alpha/beta signaling"], "10380": ["Cytosolic sulfonation of small molecules"], "10381": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "Gap junction assembly", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Recruitment of NuMA to mitotic centrosomes", "Prefoldin mediated transfer of substrate to CCT/TriC", "Formation of tubulin folding intermediates by CCT/TriC", "Post-chaperonin tubulin folding pathway", "Recycling pathway of L1", "Recycling pathway of L1", "Hedgehog 'off' state", "Cilium Assembly", "Intraflagellar transport", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "Carboxyterminal post-translational modifications of tubulin", "Carboxyterminal post-translational modifications of tubulin", "Activation of AMPK downstream of NMDARs", "Kinesins"], "10382": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "Gap junction assembly", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Regulation of PLK1 Activity at G2/M Transition", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Prefoldin mediated transfer of substrate to CCT/TriC", "Formation of tubulin folding intermediates by CCT/TriC", "Post-chaperonin tubulin folding pathway", "Recycling pathway of L1", "Recycling pathway of L1", "Hedgehog 'off' state", "Cilium Assembly", "Anchoring of the basal body to the plasma membrane", "Intraflagellar transport", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "AURKA Activation by TPX2", "Carboxyterminal post-translational modifications of tubulin", "Carboxyterminal post-translational modifications of tubulin", "Activation of AMPK downstream of NMDARs", "Kinesins"], "10383": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "Gap junction assembly", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Regulation of PLK1 Activity at G2/M Transition", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Prefoldin mediated transfer of substrate to CCT/TriC", "Formation of tubulin folding intermediates by CCT/TriC", "Post-chaperonin tubulin folding pathway", "Recycling pathway of L1", "Recycling pathway of L1", "Hedgehog 'off' state", "Cilium Assembly", "Anchoring of the basal body to the plasma membrane", "Intraflagellar transport", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "Neutrophil degranulation", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "AURKA Activation by TPX2", "Carboxyterminal post-translational modifications of tubulin", "Carboxyterminal post-translational modifications of tubulin", "Activation of AMPK downstream of NMDARs", "Kinesins"], "10384": ["Butyrophilin (BTN) family interactions"], "10385": ["Butyrophilin (BTN) family interactions"], "10388": ["Meiotic synapsis"], "10390": ["Synthesis of PC", "Synthesis of PE"], "103910": ["EPHA-mediated growth cone collapse", "Sema4D induced cell migration and growth-cone collapse", "Smooth Muscle Contraction", "RHO GTPases activate PKNs", "RHO GTPases activate CIT", "RHO GTPases Activate ROCKs", "RHO GTPases activate PAKs", "RHO GTPases activate PAKs"], "10392": ["NOD1/2 Signaling Pathway", "NOD1/2 Signaling Pathway", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "activated TAK1 mediates p38 MAPK activation", "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "Ovarian tumor domain proteases", "Interleukin-1 signaling"], "10393": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6", "Antigen processing: Ubiquitination & Proteasome degradation"], "10394": ["Neutrophil degranulation"], "10395": ["Rho GTPase cycle"], "10396": ["Neutrophil degranulation", "Ion transport by P-type ATPases"], "10397": ["TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain"], "10398": ["EPHA-mediated growth cone collapse", "Sema4D induced cell migration and growth-cone collapse", "Smooth Muscle Contraction", "RHO GTPases activate PKNs", "RHO GTPases activate CIT", "RHO GTPases Activate ROCKs", "RHO GTPases activate PAKs", "RHO GTPases activate PAKs", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"], "10399": ["Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "TNFR1-mediated ceramide production"], "104": ["C6 deamination of adenosine", "Formation of editosomes by ADAR proteins"], "1040": ["Synthesis of PI"], "10400": ["Synthesis of PC"], "10401": ["SUMOylation of transcription factors", "SUMOylation of transcription cofactors", "SUMOylation of intracellular receptors", "SUMOylation of DNA replication proteins", "SUMOylation of immune response proteins", "Formation of Incision Complex in GG-NER"], "10402": ["Pre-NOTCH Processing in Golgi", "Keratan sulfate biosynthesis", "Sialic acid metabolism"], "10403": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "1041": ["Formation of the cornified envelope"], "10410": ["Interferon alpha/beta signaling"], "10411": ["Integrin alphaIIb beta3 signaling", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Rap1 signalling", "Regulation of insulin secretion"], "10413": ["Nuclear signaling by ERBB4", "Signaling by Hippo", "YAP1- and WWTR1 (TAZ)-stimulated gene expression", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "RUNX2 regulates osteoblast differentiation", "RUNX3 regulates YAP1-mediated transcription"], "10417": ["Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "10418": ["Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "10419": ["snRNP Assembly", "RMTs methylate histone arginines", "Regulation of TP53 Activity through Methylation"], "10421": ["mRNA Splicing - Major Pathway"], "10422": ["Antigen processing: Ubiquitination & Proteasome degradation"], "10423": ["Synthesis of PI"], "10425": ["Antigen processing: Ubiquitination & Proteasome degradation"], "10426": ["Recruitment of mitotic centrosome proteins and complexes", "Recruitment of NuMA to mitotic centrosomes"], "10427": ["Regulation of cholesterol biosynthesis by SREBP (SREBF)", "COPII-mediated vesicle transport", "MHC class II antigen presentation", "Cargo concentration in the ER", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "1043": ["Post-translational modification: synthesis of GPI-anchored proteins"], "10432": ["RUNX2 regulates bone development"], "10434": ["eNOS activation"], "10435": ["MAPK6/MAPK4 signaling"], "10436": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "10437": ["MHC class II antigen presentation", "Interferon gamma signaling"], "10438": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "10440": ["Mitochondrial protein import", "Mitochondrial protein import"], "10445": ["HATs acetylate histones", "UCH proteinases", "DNA Damage Recognition in GG-NER"], "10447": ["Platelet degranulation "], "10449": ["Mitochondrial Fatty Acid Beta-Oxidation"], "1045": ["Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)"], "10450": ["Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Neutrophil degranulation", "mRNA Splicing - Major Pathway"], "10451": ["GPVI-mediated activation cascade", "GPVI-mediated activation cascade", "NRAGE signals death through JNK", "Rho GTPase cycle", "Regulation of actin dynamics for phagocytic cup formation", "DAP12 signaling", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "EPH-ephrin mediated repulsion of cells", "G alpha (12/13) signalling events", "VEGFA-VEGFR2 Pathway", "VEGFA-VEGFR2 Pathway", "VEGFR2 mediated vascular permeability"], "10452": ["Mitochondrial protein import", "Pink/Parkin Mediated Mitophagy"], "10454": ["NOD1/2 Signaling Pathway", "FCERI mediated NF-kB activation", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "activated TAK1 mediates p38 MAPK activation", "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "TNFR1-induced NFkappaB signaling pathway", "CLEC7A (Dectin-1) signaling", "Ub-specific processing proteases", "TICAM1,TRAF6-dependent induction of TAK1 complex", "Interleukin-1 signaling", "IRAK2 mediated activation of TAK1 complex", "TRAF6-mediated induction of TAK1 complex within TLR4 complex", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"], "10455": ["Beta-oxidation of very long chain fatty acids", "Peroxisomal protein import", "Peroxisomal protein import"], "10457": ["PTK6 promotes HIF1A stabilization"], "10458": ["Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs"], "10459": ["Translesion synthesis by REV1", "Translesion synthesis by POLK", "Translesion synthesis by POLI"], "10460": ["NOTCH3 Activation and Transmission of Signal to the Nucleus", "Negative regulation of NOTCH4 signaling"], "10461": ["Cell surface interactions at the vascular wall"], "10462": ["Dectin-2 family"], "10465": ["mRNA Splicing - Major Pathway"], "10466": ["COPI-mediated anterograde transport", "Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network"], "10468": ["Antagonism of Activin by Follistatin"], "10469": ["Mitochondrial protein import"], "10471": ["Prefoldin mediated transfer of substrate to CCT/TriC"], "10474": ["HATs acetylate histones", "Ub-specific processing proteases"], "10475": ["Interferon gamma signaling"], "10476": ["Formation of ATP by chemiosmotic coupling", "Cristae formation"], "10477": ["Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Antigen processing: Ubiquitination & Proteasome degradation"], "10478": ["Alpha-oxidation of phytanate"], "10479": ["Sodium/Proton exchangers", "Defective SLC9A6 causes X-linked, syndromic mental retardation,, Christianson type (MRXSCH)"], "1048": ["Post-translational modification: synthesis of GPI-anchored proteins", "Cell surface interactions at the vascular wall"], "10480": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "10482": ["Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript"], "10484": ["Regulation of cholesterol biosynthesis by SREBP (SREBF)", "COPII-mediated vesicle transport", "MHC class II antigen presentation", "Cargo concentration in the ER", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "10486": ["Role of ABL in ROBO-SLIT signaling"], "10487": ["Platelet degranulation ", "Role of ABL in ROBO-SLIT signaling", "Neutrophil degranulation"], "10488": ["CREB3 factors activate genes", "CREB3 factors activate genes"], "10489": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "10490": ["Platelet degranulation "], "104909134": ["Class B/2 (Secretin family receptors)", "G alpha (s) signalling events"], "10491": ["Collagen biosynthesis and modifying enzymes"], "10493": ["Neutrophil degranulation"], "10497": ["Serotonin Neurotransmitter Release Cycle", "Norepinephrine Neurotransmitter Release Cycle", "Glutamate Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle", "Acetylcholine Neurotransmitter Release Cycle"], "10498": ["RORA activates gene expression", "BMAL1:CLOCK,NPAS2 activates circadian gene expression", "PPARA activates gene expression", "PPARA activates gene expression", "Transcriptional activation of mitochondrial biogenesis", "Activation of gene expression by SREBF (SREBP)", "RMTs methylate histone arginines", "Transcriptional regulation of white adipocyte differentiation", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)", "Circadian Clock", "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "Estrogen-dependent gene expression"], "10499": ["RORA activates gene expression", "BMAL1:CLOCK,NPAS2 activates circadian gene expression", "Recycling of bile acids and salts", "Synthesis of bile acids and bile salts", "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "PPARA activates gene expression", "PPARA activates gene expression", "Endogenous sterols", "Transcriptional activation of mitochondrial biogenesis", "Activation of gene expression by SREBF (SREBP)", "HATs acetylate histones", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation", "SUMOylation of transcription cofactors", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)", "Circadian Clock", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Estrogen-dependent gene expression"], "1050": ["Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "10507": ["Sema4D mediated inhibition of cell attachment and migration", "Sema4D induced cell migration and growth-cone collapse", "Other semaphorin interactions"], "1051": ["Senescence-Associated Secretory Phenotype (SASP)", "Senescence-Associated Secretory Phenotype (SASP)", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "10514": ["B-WICH complex positively regulates rRNA expression"], "10516": ["Elastic fibre formation", "Molecules associated with elastic fibres", "Molecules associated with elastic fibres"], "10517": ["Association of TriC/CCT with target proteins during biosynthesis", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "1052": ["Transcriptional regulation of white adipocyte differentiation", "Interleukin-4 and Interleukin-13 signaling"], "10520": ["Generic Transcription Pathway"], "10521": ["SUMOylation of transcription cofactors"], "10523": ["mRNA Splicing - Major Pathway"], "10524": ["Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "DNA Damage/Telomere Stress Induced Senescence", "HATs acetylate histones", "HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Sensing of DNA Double Strand Breaks", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Nonhomologous End-Joining (NHEJ)", "Homologous DNA Pairing and Strand Exchange", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Regulation of TP53 Activity through Phosphorylation", "G2/M DNA damage checkpoint", "Estrogen-dependent gene expression"], "10525": ["Scavenging by Class F Receptors", "Scavenging by Class F Receptors", "XBP1(S) activates chaperone genes"], "10526": ["Transcriptional regulation by small RNAs"], "10528": ["Association of TriC/CCT with target proteins during biosynthesis", "rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "10531": ["Mitochondrial protein import"], "10533": ["Macroautophagy", "Macroautophagy", "Neutrophil degranulation", "Signaling by BRAF and RAF fusions", "Antigen processing: Ubiquitination & Proteasome degradation"], "10536": ["Collagen biosynthesis and modifying enzymes"], "10537": ["Neddylation"], "10538": ["Interleukin-4 and Interleukin-13 signaling"], "10539": ["Iron uptake and transport"], "10540": ["MHC class II antigen presentation", "Regulation of PLK1 Activity at G2/M Transition", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic", "AURKA Activation by TPX2"], "10542": ["Macroautophagy", "mTOR signalling", "mTORC1-mediated signalling", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Regulation of PTEN gene transcription"], "10544": ["Common Pathway of Fibrin Clot Formation", "Cell surface interactions at the vascular wall"], "10549": ["Neutrophil degranulation"], "10550": ["Glutamate Neurotransmitter Release Cycle"], "10552": ["Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "EPHB-mediated forward signaling", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs", "Clathrin-mediated endocytosis"], "10554": ["Synthesis of PA", "ChREBP activates metabolic gene expression"], "10555": ["Synthesis of PA", "Neutrophil degranulation"], "10556": ["tRNA processing in the nucleus", "Major pathway of rRNA processing in the nucleolus and cytosol"], "10557": ["tRNA processing in the nucleus", "Major pathway of rRNA processing in the nucleolus and cytosol"], "10558": ["Sphingolipid de novo biosynthesis"], "10559": ["Sialic acid metabolism", "Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F)", "Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F)", "Transport of nucleotide sugars"], "10560": ["Vitamin B1 (thiamin) metabolism"], "10562": ["Neutrophil degranulation"], "10563": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "10564": ["Association of TriC/CCT with target proteins during biosynthesis"], "10568": ["Type II Na+/Pi cotransporters", "Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM)", "Surfactant metabolism", "Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM)"], "10569": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing"], "10570": ["CRMPs in Sema3A signaling"], "10573": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "10574": ["Prefoldin mediated transfer of substrate to CCT/TriC", "Formation of tubulin folding intermediates by CCT/TriC", "Folding of actin by CCT/TriC", "Association of TriC/CCT with target proteins during biosynthesis", "Association of TriC/CCT with target proteins during biosynthesis", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "10575": ["Prefoldin mediated transfer of substrate to CCT/TriC", "Formation of tubulin folding intermediates by CCT/TriC", "Folding of actin by CCT/TriC", "Association of TriC/CCT with target proteins during biosynthesis", "Association of TriC/CCT with target proteins during biosynthesis", "BBSome-mediated cargo-targeting to cilium", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "10576": ["Prefoldin mediated transfer of substrate to CCT/TriC", "Formation of tubulin folding intermediates by CCT/TriC", "Folding of actin by CCT/TriC", "Association of TriC/CCT with target proteins during biosynthesis", "Association of TriC/CCT with target proteins during biosynthesis", "BBSome-mediated cargo-targeting to cilium", "Neutrophil degranulation", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "10577": ["Neutrophil degranulation", "LDL clearance"], "10578": ["Antimicrobial peptides"], "1058": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Deposition of new CENPA-containing nucleosomes at the centromere", "Mitotic Prometaphase"], "10580": ["Smooth Muscle Contraction"], "10581": ["Interferon alpha/beta signaling"], "10584": ["Lectin pathway of complement activation", "Initial triggering of complement"], "10585": ["Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1", "O-linked glycosylation"], "10587": ["Detoxification of Reactive Oxygen Species"], "10588": ["Metabolism of folate and pterines"], "10589": ["Signaling by NODAL", "Signaling by Activin"], "10591": ["Purine catabolism"], "10592": ["Condensation of Prophase Chromosomes", "Condensation of Prometaphase Chromosomes", "Condensation of Prometaphase Chromosomes"], "10594": ["mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "10599": ["Recycling of bile acids and salts", "Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)", "Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)", "Transport of organic anions"], "1060": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Deposition of new CENPA-containing nucleosomes at the centromere", "Mitotic Prometaphase"], "10600": ["Ub-specific processing proteases"], "10602": ["MAPK6/MAPK4 signaling"], "10603": ["Regulation of KIT signaling", "Factors involved in megakaryocyte development and platelet production"], "10605": ["Deadenylation of mRNA"], "10606": ["Purine ribonucleoside monophosphate biosynthesis"], "10607": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "10610": ["Sialic acid metabolism", "Termination of O-glycan biosynthesis"], "10611": ["Neurexins and neuroligins"], "10612": ["Interferon gamma signaling"], "10613": ["ABC-family proteins mediated transport", "Defective CFTR causes cystic fibrosis"], "10616": ["Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "Antigen processing: Ubiquitination & Proteasome degradation"], "10617": ["Metalloprotease DUBs"], "10618": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Golgi Associated Vesicle Biogenesis", "Retrograde transport at the Trans-Golgi-Network", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "Post-translational protein phosphorylation"], "1062": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "COPI-dependent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "Kinesins"], "10621": ["Cytosolic sensors of pathogen-associated DNA ", "RNA Polymerase III Chain Elongation", "RNA Polymerase III Transcription Termination", "RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "10622": ["Cytosolic sensors of pathogen-associated DNA ", "RNA Polymerase III Chain Elongation", "RNA Polymerase III Transcription Termination", "RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "10623": ["Cytosolic sensors of pathogen-associated DNA ", "RNA Polymerase III Chain Elongation", "RNA Polymerase III Transcription Termination", "RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "10627": ["EPHA-mediated growth cone collapse", "Ephrin signaling", "Sema4D induced cell migration and growth-cone collapse", "Smooth Muscle Contraction", "RHO GTPases activate PKNs", "RHO GTPases activate CIT", "RHO GTPases Activate ROCKs", "RHO GTPases activate PAKs", "RHO GTPases activate PAKs"], "10628": ["The NLRP3 inflammasome", "The NLRP3 inflammasome", "Regulation of FOXO transcriptional activity by acetylation"], "10629": ["HATs acetylate histones"], "1063": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Polo-like kinase mediated events", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "10630": ["GPVI-mediated activation cascade"], "10632": ["Formation of ATP by chemiosmotic coupling", "Cristae formation"], "10635": ["HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange"], "10636": ["G alpha (i) signalling events", "G alpha (i) signalling events"], "10637": ["Signaling by NODAL", "Regulation of signaling by NODAL"], "10640": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Insulin processing", "VxPx cargo-targeting to cilium"], "10642": ["Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA", "MAPK6/MAPK4 signaling"], "10643": ["Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA"], "10644": ["Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA"], "10645": ["CaMK IV-mediated phosphorylation of CREB", "CaMK IV-mediated phosphorylation of CREB", "CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "Activation of RAC1 downstream of NMDARs", "Activation of RAC1 downstream of NMDARs", "Activation of AMPK downstream of NMDARs"], "10650": ["TP53 Regulates Transcription of Genes Involved in Cytochrome C Release"], "10651": ["Mitochondrial protein import", "Cristae formation"], "10652": ["COPII-mediated vesicle transport", "COPI-mediated anterograde transport", "Intra-Golgi traffic"], "10653": ["MET Receptor Activation", "Signaling by MST1"], "10654": ["Cholesterol biosynthesis", "Activation of gene expression by SREBF (SREBP)"], "10656": ["PTK6 Regulates Proteins Involved in RNA Processing"], "10657": ["PTK6 Regulates Proteins Involved in RNA Processing"], "1066": ["Metabolism of Angiotensinogen to Angiotensins", "Phase I - Functionalization of compounds"], "10663": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "10664": ["Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "10666": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "10667": ["Mitochondrial tRNA aminoacylation"], "10670": ["Macroautophagy", "mTOR signalling", "mTORC1-mediated signalling", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "E3 ubiquitin ligases ubiquitinate target proteins", "Regulation of PTEN gene transcription"], "10671": ["MHC class II antigen presentation", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic"], "10672": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events", "Thromboxane signalling through TP receptor", "Thrombin signalling through proteinase activated receptors (PARs)", "Thrombin signalling through proteinase activated receptors (PARs)"], "10673": ["TNFR2 non-canonical NF-kB pathway", "TNFs bind their physiological receptors", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "10675": ["A tetrasaccharide linker sequence is required for GAG synthesis", "Chondroitin sulfate biosynthesis", "Dermatan sulfate biosynthesis", "CS/DS degradation", "Defective B4GALT7 causes EDS, progeroid type", "Defective B3GAT3 causes JDSSDHD", "Defective CHST3 causes SEDCJD", "Defective CHST14 causes EDS, musculocontractural type", "Defective CHSY1 causes TPBS", "Defective B3GALT6 causes EDSP2 and SEMDJL1"], "10678": ["Keratan sulfate biosynthesis", "O-linked glycosylation of mucins"], "10681": ["G-protein activation", "Inactivation, recovery and regulation of the phototransduction cascade", "Inactivation, recovery and regulation of the phototransduction cascade", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42"], "10682": ["Cholesterol biosynthesis via desmosterol", "Cholesterol biosynthesis via lathosterol"], "106821730": ["Activation of RAC1"], "10686": ["Tight junction interactions"], "1069": ["Regulation of PLK1 Activity at G2/M Transition", "SUMOylation of DNA damage response and repair proteins", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "DNA Damage Recognition in GG-NER", "Formation of Incision Complex in GG-NER", "AURKA Activation by TPX2"], "10692": ["G alpha (i) signalling events", "Opsins"], "10693": ["Prefoldin mediated transfer of substrate to CCT/TriC", "Formation of tubulin folding intermediates by CCT/TriC", "Folding of actin by CCT/TriC", "Association of TriC/CCT with target proteins during biosynthesis", "Association of TriC/CCT with target proteins during biosynthesis", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "10694": ["Prefoldin mediated transfer of substrate to CCT/TriC", "Formation of tubulin folding intermediates by CCT/TriC", "Folding of actin by CCT/TriC", "Association of TriC/CCT with target proteins during biosynthesis", "Association of TriC/CCT with target proteins during biosynthesis", "BBSome-mediated cargo-targeting to cilium", "Neutrophil degranulation", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "10695": ["Trafficking and processing of endosomal TLR"], "10699": ["Physiological factors"], "107": ["Glucagon signaling in metabolic regulation", "PKA activation", "PKA activation in glucagon signalling", "Adenylate cyclase activating pathway", "Adenylate cyclase inhibitory pathway", "Adenylate cyclase inhibitory pathway", "G alpha (s) signalling events", "G alpha (s) signalling events", "G alpha (i) signalling events", "G alpha (z) signalling events", "G alpha (z) signalling events", "Vasopressin regulates renal water homeostasis via Aquaporins", "CREB1 phosphorylation through the activation of Adenylate Cyclase", "Hedgehog 'off' state"], "107080638": ["TBC/RABGAPs"], "1071": ["LDL remodeling", "HDL remodeling"], "10713": ["mRNA Splicing - Major Pathway"], "10714": ["Recognition of DNA damage by PCNA-containing replication complex", "Polymerase switching on the C-strand of the telomere", "Processive synthesis on the C-strand of the telomere", "Telomere C-strand (Lagging Strand) Synthesis", "Removal of the Flap Intermediate from the C-strand", "Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "PCNA-Dependent Long Patch Base Excision Repair", "Termination of translesion DNA synthesis", "HDR through Homologous Recombination (HRR)", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Polymerase switching", "Removal of the Flap Intermediate", "Processive synthesis on the lagging strand"], "10715": ["Sphingolipid de novo biosynthesis"], "10717": ["Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis"], "10718": ["Signaling by ERBB2", "Signaling by ERBB4", "SHC1 events in ERBB2 signaling", "SHC1 events in ERBB2 signaling", "PI3K events in ERBB4 signaling", "SHC1 events in ERBB4 signaling", "Nuclear signaling by ERBB4", "PIP3 activates AKT signaling", "GRB2 events in ERBB2 signaling", "PI3K events in ERBB2 signaling", "Constitutive Signaling by Aberrant PI3K in Cancer", "RAF/MAP kinase cascade", "ERBB2 Regulates Cell Motility", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "ERBB2 Activates PTK6 Signaling", "Downregulation of ERBB2 signaling"], "1072": ["Platelet degranulation ", "Regulation of actin dynamics for phagocytic cup formation", "EPHB-mediated forward signaling", "Sema3A PAK dependent Axon repulsion", "RHO GTPases Activate ROCKs", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "10720": ["Glucuronidation"], "10721": ["HDR through MMEJ (alt-NHEJ)"], "10723": ["Cation-coupled Chloride cotransporters"], "10726": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase", "Mitotic Telophase/Cytokinesis"], "10728": ["Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "HSF1 activation", "Attenuation phase", "Aryl hydrocarbon receptor signalling", "ESR-mediated signaling", "Estrogen-dependent gene expression"], "10730": ["Processing of SMDT1"], "10733": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "10734": ["Meiotic synapsis"], "10735": ["Meiotic synapsis", "Separation of Sister Chromatids", "Establishment of Sister Chromatid Cohesion", "Cohesin Loading onto Chromatin", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA damage response and repair proteins", "Estrogen-dependent gene expression"], "10743": ["Circadian Clock"], "10747": ["Lectin pathway of complement activation", "Initial triggering of complement", "Ficolins bind to repetitive carbohydrate structures on the target cell surface"], "10749": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "1075": ["COPII-mediated vesicle transport", "MHC class II antigen presentation", "Cargo concentration in the ER", "Neutrophil degranulation"], "10750": ["Signaling by SCF-KIT"], "10752": ["CHL1 interactions"], "10753": ["Degradation of the extracellular matrix"], "10762": ["ISG15 antiviral mechanism", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "tRNA processing in the nucleus"], "10765": ["HDMs demethylate histones", "TFAP2 (AP-2) family regulates transcription of cell cycle factors"], "10767": ["mRNA decay by 3' to 5' exoribonuclease"], "10768": ["PLC beta mediated events", "DAG and IP3 signaling", "Role of phospholipids in phagocytosis", "FCERI mediated Ca+2 mobilization", "Regulation of insulin secretion", "VEGFR2 mediated cell proliferation", "Ion homeostasis", "Ion homeostasis", "CLEC7A (Dectin-1) induces NFAT activation", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "10769": ["TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "10772": ["mRNA Splicing - Major Pathway"], "10775": ["tRNA processing in the nucleus"], "10776": ["MASTL Facilitates Mitotic Progression", "MASTL Facilitates Mitotic Progression"], "10780": ["Generic Transcription Pathway"], "10781": ["Generic Transcription Pathway"], "10782": ["Generic Transcription Pathway"], "10783": ["Activation of NIMA Kinases NEK9, NEK6, NEK7", "Nuclear Pore Complex (NPC) Disassembly"], "10785": ["tRNA modification in the nucleus and cytosol"], "10786": ["Stimuli-sensing channels"], "10787": ["Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs"], "10788": ["RHO GTPases activate IQGAPs", "Neutrophil degranulation"], "10793": ["Generic Transcription Pathway"], "10794": ["Generic Transcription Pathway"], "10795": ["Generic Transcription Pathway"], "10797": ["Metabolism of folate and pterines"], "10798": ["Olfactory Signaling Pathway"], "107987462": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation"], "10799": ["tRNA processing in the nucleus", "Major pathway of rRNA processing in the nucleolus and cytosol"], "108": ["Glucagon signaling in metabolic regulation", "PKA activation", "PKA activation in glucagon signalling", "Adenylate cyclase activating pathway", "Adenylate cyclase inhibitory pathway", "Adenylate cyclase inhibitory pathway", "G alpha (s) signalling events", "G alpha (s) signalling events", "G alpha (i) signalling events", "G alpha (z) signalling events", "G alpha (z) signalling events", "Vasopressin regulates renal water homeostasis via Aquaporins", "Hedgehog 'off' state"], "1080": ["ABC-family proteins mediated transport", "RHO GTPases regulate CFTR trafficking", "Defective CFTR causes cystic fibrosis", "Ub-specific processing proteases", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "10800": ["Leukotriene receptors", "G alpha (q) signalling events"], "10802": ["Regulation of cholesterol biosynthesis by SREBP (SREBF)", "COPII-mediated vesicle transport", "MHC class II antigen presentation", "Cargo concentration in the ER", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "10803": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "10804": ["Gap junction assembly"], "10806": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "10808": ["Scavenging by Class F Receptors", "Scavenging by Class F Receptors", "Regulation of HSF1-mediated heat shock response"], "10809": ["Synthesis of PC"], "1081": ["Androgen biosynthesis", "Mineralocorticoid biosynthesis", "Glycoprotein hormones", "Thyroxine biosynthesis", "Hormone ligand-binding receptors", "G alpha (s) signalling events", "TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "Reactions specific to the complex N-glycan synthesis pathway"], "10810": ["Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs"], "10811": ["RHO GTPases Activate NADPH Oxidases"], "10813": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "10815": ["Serotonin Neurotransmitter Release Cycle", "Norepinephrine Neurotransmitter Release Cycle", "Glutamate Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle", "Acetylcholine Neurotransmitter Release Cycle", "GABA synthesis, release, reuptake and degradation"], "10817": ["FRS-mediated FGFR1 signaling", "FRS-mediated FGFR2 signaling", "FRS-mediated FGFR3 signaling", "FRS-mediated FGFR4 signaling", "RAF/MAP kinase cascade", "Activated NTRK2 signals through FRS2 and FRS3"], "10818": ["PI3K Cascade", "PIP3 activates AKT signaling", "Frs2-mediated activation", "Frs2-mediated activation", "Constitutive Signaling by Aberrant PI3K in Cancer", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "FRS-mediated FGFR2 signaling", "FRS-mediated FGFR3 signaling", "PI-3K cascade:FGFR3", "FRS-mediated FGFR4 signaling", "PI-3K cascade:FGFR4", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "Signaling by FGFR2 in disease", "Signaling by FGFR4 in disease", "Signaling by FGFR1 in disease", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Signaling by FGFR3 fusions in cancer", "Signaling by FGFR3 point mutants in cancer", "RET signaling", "Activated NTRK2 signals through FRS2 and FRS3", "Activated NTRK2 signals through FRS2 and FRS3"], "1082": ["Glycoprotein hormones", "TFAP2 (AP-2) family regulates transcription of growth factors and their receptors"], "10825": ["Glycosphingolipid metabolism", "Sialic acid metabolism"], "10827": ["Signaling by BRAF and RAF fusions"], "1084": ["Cell surface interactions at the vascular wall", "Neutrophil degranulation"], "10840": ["Metabolism of folate and pterines"], "10841": ["Histidine catabolism"], "10844": ["Recruitment of mitotic centrosome proteins and complexes", "Recruitment of NuMA to mitotic centrosomes"], "10846": ["cGMP effects", "G alpha (s) signalling events"], "10848": ["Regulation of TP53 Activity through Association with Co-factors"], "10849": ["NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase I Transcription Termination"], "10850": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "10855": ["HS-GAG degradation", "Neutrophil degranulation"], "10856": ["Telomere Extension By Telomerase", "HATs acetylate histones"], "10857": ["Neutrophil degranulation"], "10858": ["Synthesis of bile acids and bile salts via 24-hydroxycholesterol", "Endogenous sterols"], "10859": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "10861": ["Transport and synthesis of PAPS", "Multifunctional anion exchangers"], "10864": ["Organic anion transport"], "10868": ["Ub-specific processing proteases"], "10869": ["Ub-specific processing proteases"], "1087": ["Post-translational modification: synthesis of GPI-anchored proteins"], "10870": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "10871": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "10873": ["Citric acid cycle (TCA cycle)"], "10874": ["Peptide ligand-binding receptors", "G alpha (q) signalling events", "G alpha (i) signalling events"], "10875": ["Neutrophil degranulation"], "10877": ["Regulation of Complement cascade"], "10878": ["Regulation of Complement cascade"], "1088": ["Fibronectin matrix formation", "Cell surface interactions at the vascular wall", "Neutrophil degranulation"], "10884": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "10885": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "10886": ["Orexin and neuropeptides FF and QRFP bind to their respective receptors", "G alpha (q) signalling events"], "10887": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "10888": ["G alpha (s) signalling events"], "10890": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Neutrophil degranulation", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "10891": ["PPARA activates gene expression", "Transcriptional activation of mitochondrial biogenesis", "Activation of PPARGC1A (PGC-1alpha) by phosphorylation", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation", "SUMOylation of transcription cofactors", "Circadian Clock", "Circadian Clock", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes"], "10892": ["Activation of NF-kappaB in B cells", "Activation of NF-kappaB in B cells", "Downstream TCR signaling", "FCERI mediated NF-kB activation", "FCERI mediated NF-kB activation", "CLEC7A (Dectin-1) signaling", "CLEC7A/inflammasome pathway"], "10893": ["Activation of Matrix Metalloproteinases"], "10894": ["Hyaluronan uptake and degradation"], "10897": ["XBP1(S) activates chaperone genes"], "10898": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA Derived from an Intronless Transcript", "Inhibition of Host mRNA Processing and RNA Silencing", "tRNA processing in the nucleus", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "109": ["Glucagon signaling in metabolic regulation", "PKA activation", "PKA activation in glucagon signalling", "Adenylate cyclase activating pathway", "Adenylate cyclase inhibitory pathway", "Adenylate cyclase inhibitory pathway", "G alpha (s) signalling events", "G alpha (s) signalling events", "G alpha (i) signalling events", "G alpha (z) signalling events", "G alpha (z) signalling events", "Vasopressin regulates renal water homeostasis via Aquaporins", "Hedgehog 'off' state"], "10901": ["RA biosynthesis pathway", "Peroxisomal protein import", "Peroxisomal protein import"], "10902": ["HATs acetylate histones"], "10905": ["Intra-Golgi traffic", "Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2"], "10907": ["mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "10908": ["Glycerophospholipid catabolism"], "10910": ["The NLRP3 inflammasome"], "10911": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "10913": ["TNFs bind their physiological receptors"], "10914": ["Cleavage of Growing Transcript in the Termination Region ", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "10916": ["Platelet degranulation "], "10919": ["Senescence-Associated Secretory Phenotype (SASP)", "PKMTs methylate histone lysines", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "Regulation of TP53 Activity through Methylation", "RNA Polymerase I Transcription Initiation", "Transcriptional Regulation by E2F6"], "10920": ["DNA Damage Recognition in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Cargo recognition for clathrin-mediated endocytosis", "Neddylation"], "10921": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "10926": ["Activation of ATR in response to replication stress", "Activation of the pre-replicative complex"], "10928": ["Rho GTPase cycle"], "10930": ["mRNA Editing: C to U Conversion", "Formation of the Editosome"], "10933": ["HATs acetylate histones"], "10935": ["Detoxification of Reactive Oxygen Species"], "10938": ["Factors involved in megakaryocyte development and platelet production"], "10939": ["Processing of SMDT1"], "10940": ["tRNA processing in the nucleus"], "10941": ["Glucuronidation"], "10942": ["Post-translational modification: synthesis of GPI-anchored proteins"], "10943": ["HATs acetylate histones"], "10945": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "10946": ["mRNA Splicing - Major Pathway"], "10948": ["Pregnenolone biosynthesis"], "10949": ["mRNA Splicing - Major Pathway", "Processing of Capped Intron-Containing Pre-mRNA"], "10952": ["ER-Phagosome pathway", "SRP-dependent cotranslational protein targeting to membrane", "XBP1(S) activates chaperone genes"], "10954": ["XBP1(S) activates chaperone genes"], "10955": ["Serine biosynthesis"], "10956": ["ABC-family proteins mediated transport", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Defective CFTR causes cystic fibrosis", "ER Quality Control Compartment (ERQC)"], "10959": ["Pre-NOTCH Processing in Golgi", "COPII-mediated vesicle transport", "Cargo concentration in the ER", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "10960": ["COPII-mediated vesicle transport", "Cargo concentration in the ER"], "10963": ["HSP90 chaperone cycle for steroid hormone receptors (SHR)"], "10965": ["Mitochondrial Fatty Acid Beta-Oxidation", "Peroxisomal protein import", "Peroxisomal protein import"], "10966": ["RAB geranylgeranylation"], "10969": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "10970": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Surfactant metabolism", "Neutrophil degranulation", "Post-translational protein phosphorylation"], "109703458": ["Fatty acyl-CoA biosynthesis"], "10971": ["Activation of BAD and translocation to mitochondria ", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "RHO GTPases activate PKNs", "TP53 Regulates Metabolic Genes", "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "Regulation of localization of FOXO transcription factors"], "10972": ["COPII-mediated vesicle transport", "Cargo concentration in the ER", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "10973": ["ALKBH3 mediated reversal of alkylation damage"], "10974": ["Transcriptional regulation of white adipocyte differentiation"], "10975": ["Respiratory electron transport"], "10978": ["Cleavage of Growing Transcript in the Termination Region ", "tRNA processing in the nucleus", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "10979": ["Cell-extracellular matrix interactions"], "10980": ["DNA Damage Recognition in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Cargo recognition for clathrin-mediated endocytosis", "Neddylation"], "10981": ["RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "10987": ["DNA Damage Recognition in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Cargo recognition for clathrin-mediated endocytosis", "Neddylation"], "10988": ["Inactivation, recovery and regulation of the phototransduction cascade"], "10989": ["Cristae formation"], "10990": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "10991": ["Amino acid transport across the plasma membrane"], "10992": ["mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "10993": ["Threonine catabolism"], "10998": ["Recycling of bile acids and salts", "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of bile acids and bile salts via 24-hydroxycholesterol"], "10999": ["Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS)", "Transport of fatty acids"], "11000": ["Synthesis of very long-chain fatty acyl-CoAs"], "11001": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of bile acids and bile salts via 24-hydroxycholesterol", "Alpha-oxidation of phytanate", "Neutrophil degranulation", "Peroxisomal protein import", "Peroxisomal protein import"], "11004": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "COPI-dependent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "Kinesins"], "11005": ["Formation of the cornified envelope"], "11006": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "11009": ["Interleukin-20 family signaling"], "11010": ["PPARA activates gene expression", "Neutrophil degranulation"], "11014": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "11015": ["XBP1(S) activates chaperone genes", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "11017": ["mRNA Splicing - Major Pathway"], "11019": ["Glyoxylate metabolism and glycine degradation"], "11020": ["Intraflagellar transport", "Intraflagellar transport"], "11021": ["TBC/RABGAPs", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "11022": ["PIWI-interacting RNA (piRNA) biogenesis"], "11024": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "11026": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation"], "11027": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "1103": ["Synthesis of PC", "Acetylcholine Neurotransmitter Release Cycle"], "11031": ["Neutrophil degranulation", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "11035": ["TICAM1, RIP1-mediated IKK complex recruitment ", "RIP-mediated NFkB activation via ZBP1", "TRIF-mediated programmed cell death", "TRP channels", "RIPK1-mediated regulated necrosis", "TLR3-mediated TICAM1-dependent programmed cell death", "IKK complex recruitment mediated by RIP1"], "11037": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "1104": ["Rev-mediated nuclear export of HIV RNA", "Nuclear import of Rev protein"], "11041": ["Keratan sulfate biosynthesis", "O-linked glycosylation"], "11044": ["Signaling by BRAF and RAF fusions"], "11046": ["Keratan sulfate biosynthesis", "HS-GAG biosynthesis", "Transport of nucleotide sugars"], "11047": ["UCH proteinases", "Ub-specific processing proteases"], "1105": ["Estrogen-dependent gene expression"], "11051": ["Cleavage of Growing Transcript in the Termination Region ", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "11052": ["Signaling by cytosolic FGFR1 fusion mutants", "Signaling by FGFR1 in disease"], "11056": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "11059": ["Downregulation of ERBB4 signaling", "Stimuli-sensing channels", "Regulation of RUNX2 expression and activity", "Antigen processing: Ubiquitination & Proteasome degradation"], "110599583": ["Peptide ligand-binding receptors"], "11060": ["Regulation of PTEN stability and activity", "NOTCH3 Activation and Transmission of Signal to the Nucleus"], "11064": ["Signaling by cytosolic FGFR1 fusion mutants", "Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "Signaling by FGFR1 in disease", "AURKA Activation by TPX2"], "11065": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Antigen processing: Ubiquitination & Proteasome degradation"], "11066": ["mRNA Splicing - Minor Pathway"], "11069": ["Integrin alphaIIb beta3 signaling", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Rap1 signalling", "Regulation of insulin secretion"], "1107": ["HDACs deacetylate histones", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "SUMOylation of chromatin organization proteins", "Regulation of TP53 Activity through Acetylation", "RNA Polymerase I Transcription Initiation", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription"], "11070": ["COPI-mediated anterograde transport"], "11073": ["HDR through Single Strand Annealing (SSA)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Regulation of TP53 Activity through Phosphorylation", "G2/M DNA damage checkpoint"], "11074": ["Interferon gamma signaling"], "1108": ["HDACs deacetylate histones", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "Regulation of TP53 Activity through Acetylation", "RNA Polymerase I Transcription Initiation", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription"], "11081": ["Keratan sulfate biosynthesis", "Keratan sulfate degradation", "Defective CHST6 causes MCDC1", "Defective ST3GAL3 causes MCT12 and EIEE15", "Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)"], "11083": ["Meiotic synapsis"], "11085": ["Interaction With The Zona Pellucida"], "1109": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of bile acids and bile salts via 24-hydroxycholesterol", "Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "Retinoid metabolism and transport"], "11091": ["PKMTs methylate histone lysines", "HATs acetylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Neddylation"], "11093": ["Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "11094": ["Presynaptic depolarization and calcium channel opening"], "11095": ["Degradation of the extracellular matrix", "Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "11096": ["Degradation of the extracellular matrix", "Degradation of the extracellular matrix", "Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "11097": ["ISG15 antiviral mechanism", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "tRNA processing in the nucleus"], "11098": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "111": ["Glucagon signaling in metabolic regulation", "PKA activation", "PKA activation in glucagon signalling", "Adenylate cyclase activating pathway", "Adenylate cyclase inhibitory pathway", "Adenylate cyclase inhibitory pathway", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Adrenaline,noradrenaline inhibits insulin secretion", "G alpha (s) signalling events", "G alpha (s) signalling events", "G alpha (i) signalling events", "G alpha (z) signalling events", "G alpha (z) signalling events", "Vasopressin regulates renal water homeostasis via Aquaporins", "Hedgehog 'off' state"], "11100": ["mRNA Splicing - Major Pathway"], "11102": ["tRNA processing in the nucleus", "Major pathway of rRNA processing in the nucleolus and cytosol"], "11103": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "11105": ["Generic Transcription Pathway"], "11108": ["p75NTR negatively regulates cell cycle via SC1"], "1111": ["Signaling by SCF-KIT", "Activation of ATR in response to replication stress", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "TP53 Regulates Transcription of DNA Repair Genes", "Regulation of TP53 Activity through Phosphorylation", "G2/M DNA damage checkpoint", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "Transcriptional Regulation by E2F6"], "11112": ["Branched-chain amino acid catabolism"], "11113": ["RHO GTPases activate CIT", "RHO GTPases activate CIT"], "11116": ["Signaling by cytosolic FGFR1 fusion mutants", "Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "Signaling by FGFR1 in disease", "AURKA Activation by TPX2"], "11117": ["Molecules associated with elastic fibres", "Molecules associated with elastic fibres"], "11118": ["Butyrophilin (BTN) family interactions"], "11119": ["Butyrophilin (BTN) family interactions"], "11120": ["Butyrophilin (BTN) family interactions"], "11126": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "11127": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "MHC class II antigen presentation", "Hedgehog 'off' state", "Intraflagellar transport", "Activation of SMO", "Activation of SMO", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins", "Kinesins"], "11128": ["Cytosolic sensors of pathogen-associated DNA ", "RNA Polymerase III Chain Elongation", "RNA Polymerase III Transcription Termination", "RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "1113": ["Antimicrobial peptides"], "11130": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "11131": ["Degradation of the extracellular matrix"], "11132": ["Degradation of the extracellular matrix"], "11136": ["Basigin interactions", "Amino acid transport across the plasma membrane", "Defective SLC7A9 causes cystinuria (CSNU)"], "1114": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "11140": ["Signaling by ERBB2", "Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "Constitutive Signaling by EGFRvIII", "Downregulation of ERBB2 signaling"], "11141": ["Receptor-type tyrosine-protein phosphatases", "Interleukin-38 signaling"], "11143": ["HATs acetylate histones"], "11144": ["Meiotic recombination"], "11145": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PS", "Acyl chain remodelling of PE", "Acyl chain remodelling of PI"], "11146": ["Antigen processing: Ubiquitination & Proteasome degradation"], "11152": ["Macroautophagy"], "11154": ["Lysosome Vesicle Biogenesis"], "11157": ["mRNA decay by 5' to 3' exoribonuclease", "mRNA decay by 5' to 3' exoribonuclease", "mRNA Splicing - Major Pathway"], "1116": ["Neutrophil degranulation"], "11160": ["ABC-family proteins mediated transport", "Signaling by FGFR1 in disease", "Defective CFTR causes cystic fibrosis", "Signaling by plasma membrane FGFR1 fusions"], "11163": ["Synthesis of pyrophosphates in the cytosol"], "11164": ["Phosphate bond hydrolysis by NUDT proteins"], "11165": ["Synthesis of pyrophosphates in the cytosol"], "11167": ["Signaling by BMP", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "11168": ["Integration of provirus", "2-LTR circle formation", "Integration of viral DNA into host genomic DNA", "Autointegration results in viral DNA circles", "APOBEC3G mediated resistance to HIV-1 infection", "Vpr-mediated nuclear import of PICs"], "11171": ["Downregulation of TGF-beta receptor signaling", "Downregulation of TGF-beta receptor signaling"], "11173": ["Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "11174": ["Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "11176": ["NoRC negatively regulates rRNA expression"], "1118": ["Digestion of dietary carbohydrate", "Neutrophil degranulation"], "11181": ["Digestion of dietary carbohydrate"], "11182": ["Cellular hexose transport"], "11185": ["Methylation of MeSeH for excretion"], "11187": ["Keratinization", "Formation of the cornified envelope"], "1119": ["Synthesis of PC", "Synthesis of PE"], "11190": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "11193": ["mRNA Splicing - Major Pathway"], "11194": ["Mitochondrial ABC transporters"], "11196": ["COPII-mediated vesicle transport"], "11197": ["TCF dependent signaling in response to WNT", "Negative regulation of TCF-dependent signaling by WNT ligand antagonists"], "11198": ["Formation of RNA Pol II elongation complex ", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "Regulation of TP53 Activity through Phosphorylation", "RNA Polymerase II Transcription Elongation"], "112": ["Glucagon signaling in metabolic regulation", "PKA activation", "PKA activation in glucagon signalling", "Adenylate cyclase activating pathway", "Adenylate cyclase inhibitory pathway", "Adenylate cyclase inhibitory pathway", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Adrenaline,noradrenaline inhibits insulin secretion", "G alpha (s) signalling events", "G alpha (s) signalling events", "G alpha (i) signalling events", "G alpha (z) signalling events", "G alpha (z) signalling events", "Vasopressin regulates renal water homeostasis via Aquaporins", "Hedgehog 'off' state"], "1120": ["Synthesis of PC", "Synthesis of PE"], "11200": ["Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Regulation of TP53 Activity through Phosphorylation", "Regulation of TP53 Degradation", "Regulation of TP53 Activity through Methylation", "G2/M DNA damage checkpoint", "Stabilization of p53", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex"], "11201": ["Translesion synthesis by POLI", "Termination of translesion DNA synthesis"], "11202": ["Formation of the cornified envelope"], "1121": ["TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "11211": ["Class B/2 (Secretin family receptors)"], "11213": ["MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "Interleukin-1 signaling"], "11214": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "11216": ["Factors involved in megakaryocyte development and platelet production"], "11218": ["snRNP Assembly"], "1122": ["RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "11221": ["RAF-independent MAPK1/3 activation", "Negative regulation of MAPK pathway"], "11222": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "11224": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "11226": ["O-linked glycosylation of mucins"], "11227": ["O-linked glycosylation of mucins"], "1123": ["Rho GTPase cycle"], "11231": ["XBP1(S) activates chaperone genes"], "11232": ["Transcriptional activation of mitochondrial biogenesis"], "11236": ["ER Quality Control Compartment (ERQC)"], "11238": ["Reversible hydration of carbon dioxide"], "112398": ["Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"], "112399": ["Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"], "1124": ["Rho GTPase cycle"], "11240": ["Chromatin modifying enzymes", "Neutrophil degranulation"], "11243": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "11245": ["G alpha (s) signalling events"], "112495": ["RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter"], "11250": ["G alpha (s) signalling events"], "11251": ["Prostanoid ligand receptors", "G alpha (i) signalling events"], "11252": ["Clathrin-mediated endocytosis"], "11253": ["Defective MAN1B1 causes MRT15", "ER Quality Control Compartment (ERQC)"], "11254": ["Amino acid transport across the plasma membrane", "Na+/Cl- dependent neurotransmitter transporters", "Variant SLC6A14 may confer susceptibility towards obesity"], "11255": ["Histamine receptors", "G alpha (i) signalling events"], "112574": ["Clathrin-mediated endocytosis"], "11258": ["MHC class II antigen presentation", "Regulation of PLK1 Activity at G2/M Transition", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic", "AURKA Activation by TPX2"], "11260": ["tRNA processing in the nucleus"], "11261": ["Hyaluronan uptake and degradation"], "11267": ["Endosomal Sorting Complex Required For Transport (ESCRT)"], "112714": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "Gap junction assembly", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Recruitment of NuMA to mitotic centrosomes", "Formation of tubulin folding intermediates by CCT/TriC", "Post-chaperonin tubulin folding pathway", "Recycling pathway of L1", "Recycling pathway of L1", "Cilium Assembly", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "Carboxyterminal post-translational modifications of tubulin", "Carboxyterminal post-translational modifications of tubulin", "Activation of AMPK downstream of NMDARs", "Kinesins"], "112724": ["RA biosynthesis pathway"], "11274": ["ISG15 antiviral mechanism", "Ub-specific processing proteases", "Regulation of IFNA signaling"], "112744": ["Interleukin-17 signaling", "Interleukin-4 and Interleukin-13 signaling"], "11275": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "112752": ["Intraflagellar transport"], "112755": ["Toxicity of botulinum toxin type C (BoNT/C)", "LGI-ADAM interactions"], "11277": ["Regulation by TREX1", "IRF3-mediated induction of type I IFN"], "1128": ["Muscarinic acetylcholine receptors", "G alpha (q) signalling events"], "11280": ["Interaction between L1 and Ankyrins", "Phase 0 - rapid depolarisation"], "112802": ["Keratinization", "Formation of the cornified envelope"], "112812": ["Mitochondrial iron-sulfur cluster biogenesis", "Pregnenolone biosynthesis", "Endogenous sterols", "Electron transport from NADPH to Ferredoxin", "Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)"], "112817": ["Glyoxylate metabolism and glycine degradation"], "11282": ["N-Glycan antennae elongation"], "11283": ["Fatty acids", "Eicosanoids", "Synthesis of Leukotrienes (LT) and Eoxins (EX)"], "11284": ["APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway"], "11285": ["A tetrasaccharide linker sequence is required for GAG synthesis", "Defective B4GALT7 causes EDS, progeroid type"], "112858": ["tRNA modification in the nucleus and cytosol", "Regulation of TP53 Activity through Phosphorylation"], "112869": ["HATs acetylate histones"], "1129": ["Muscarinic acetylcholine receptors", "G alpha (i) signalling events", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "112950": ["PPARA activates gene expression", "Generic Transcription Pathway", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "113": ["Glucagon signaling in metabolic regulation", "PKA activation", "PKA activation in glucagon signalling", "Adenylate cyclase activating pathway", "Adenylate cyclase inhibitory pathway", "Adenylate cyclase inhibitory pathway", "G alpha (s) signalling events", "G alpha (s) signalling events", "G alpha (i) signalling events", "G alpha (z) signalling events", "G alpha (z) signalling events", "Vasopressin regulates renal water homeostasis via Aquaporins", "Hedgehog 'off' state"], "113026": ["Synthesis of IP3 and IP4 in the cytosol"], "11309": ["Transport of organic anions"], "113091": ["Class B/2 (Secretin family receptors)", "G alpha (s) signalling events"], "1131": ["Muscarinic acetylcholine receptors", "Acetylcholine regulates insulin secretion", "G alpha (q) signalling events"], "11311": ["Intra-Golgi traffic", "Factors involved in megakaryocyte development and platelet production"], "11313": ["L1CAM interactions"], "113130": ["Separation of Sister Chromatids", "Establishment of Sister Chromatid Cohesion", "Resolution of Sister Chromatid Cohesion"], "11314": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation"], "11315": ["SUMOylation of transcription cofactors"], "11316": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "113177": ["Sperm:Oocyte Membrane Binding"], "113179": ["tRNA modification in the nucleus and cytosol"], "113189": ["Dermatan sulfate biosynthesis", "Defective CHST14 causes EDS, musculocontractural type"], "1132": ["Muscarinic acetylcholine receptors", "G alpha (i) signalling events"], "11320": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation", "N-Glycan antennae elongation"], "11322": ["Neutrophil degranulation"], "113220": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "113235": ["Metabolism of folate and pterines", "Iron uptake and transport"], "11325": ["mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "113278": ["Vitamin B2 (riboflavin) metabolism"], "11328": ["Association of TriC/CCT with target proteins during biosynthesis"], "1133": ["Muscarinic acetylcholine receptors", "G alpha (q) signalling events"], "11330": ["Cobalamin (Cbl, vitamin B12) transport and metabolism"], "11331": ["Processing of SMDT1"], "11332": ["Mitochondrial Fatty Acid Beta-Oxidation"], "11333": ["Neutrophil degranulation"], "11335": ["ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "RNA Polymerase I Chain Elongation", "Transcriptional Regulation by E2F6"], "11336": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Insulin processing", "VxPx cargo-targeting to cilium"], "11337": ["Macroautophagy", "TBC/RABGAPs"], "11338": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing"], "11339": ["Deposition of new CENPA-containing nucleosomes at the centromere"], "1134": ["Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "Highly calcium permeable nicotinic acetylcholine receptors"], "11340": ["ATF4 activates genes", "mRNA decay by 3' to 5' exoribonuclease", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "KSRP (KHSRP) binds and destabilizes mRNA", "Major pathway of rRNA processing in the nucleolus and cytosol"], "11343": ["Acyl chain remodeling of DAG and TAG", "Triglyceride catabolism", "Arachidonate production from DAG"], "11345": ["Macroautophagy", "TBC/RABGAPs"], "113451": ["Agmatine biosynthesis"], "113457": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "Gap junction assembly", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Recruitment of NuMA to mitotic centrosomes", "Prefoldin mediated transfer of substrate to CCT/TriC", "Formation of tubulin folding intermediates by CCT/TriC", "Post-chaperonin tubulin folding pathway", "Recycling pathway of L1", "Recycling pathway of L1", "Hedgehog 'off' state", "Cilium Assembly", "Intraflagellar transport", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "Carboxyterminal post-translational modifications of tubulin", "Carboxyterminal post-translational modifications of tubulin", "Activation of AMPK downstream of NMDARs", "Kinesins"], "1135": ["Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "Highly calcium permeable nicotinic acetylcholine receptors"], "1136": ["Highly sodium permeable acetylcholine nicotinic receptors", "Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "Highly calcium permeable nicotinic acetylcholine receptors"], "113612": ["Miscellaneous substrates", "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)", "Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56)"], "113675": ["Threonine catabolism"], "1137": ["Highly sodium permeable acetylcholine nicotinic receptors", "Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "Highly calcium permeable nicotinic acetylcholine receptors"], "1138": ["Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "Highly calcium permeable nicotinic acetylcholine receptors"], "113802": ["PIWI-interacting RNA (piRNA) biogenesis"], "113835": ["Generic Transcription Pathway"], "113878": ["Activated NOTCH1 Transmits Signal to the Nucleus", "Activated NOTCH1 Transmits Signal to the Nucleus"], "1139": ["Highly calcium permeable postsynaptic nicotinic acetylcholine receptors"], "114": ["Glucagon signaling in metabolic regulation", "PKA activation", "PKA activation in glucagon signalling", "Adenylate cyclase activating pathway", "Adenylate cyclase inhibitory pathway", "Adenylate cyclase inhibitory pathway", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "G alpha (s) signalling events", "G alpha (s) signalling events", "G alpha (i) signalling events", "G alpha (z) signalling events", "G alpha (z) signalling events", "Vasopressin regulates renal water homeostasis via Aquaporins", "CREB1 phosphorylation through the activation of Adenylate Cyclase", "Hedgehog 'off' state"], "114026": ["Generic Transcription Pathway"], "114049": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "114088": ["Antigen processing: Ubiquitination & Proteasome degradation"], "1141": ["Highly sodium permeable acetylcholine nicotinic receptors", "Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "Highly calcium permeable nicotinic acetylcholine receptors"], "114131": ["Class B/2 (Secretin family receptors)"], "114132": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "114134": ["Inositol transporters"], "1142": ["Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "Highly calcium permeable nicotinic acetylcholine receptors"], "1143": ["Highly sodium permeable acetylcholine nicotinic receptors", "Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "Highly calcium permeable nicotinic acetylcholine receptors", "Neutrophil degranulation"], "1144": ["Highly sodium permeable acetylcholine nicotinic receptors"], "1145": ["Highly sodium permeable acetylcholine nicotinic receptors"], "114548": ["Metalloprotease DUBs", "The NLRP3 inflammasome", "The NLRP3 inflammasome"], "1146": ["Highly sodium permeable acetylcholine nicotinic receptors"], "114609": ["ER-Phagosome pathway", "MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "MyD88 deficiency (TLR2/4)", "IRAK4 deficiency (TLR2/4)"], "1147": ["Activation of NF-kappaB in B cells", "Activation of NF-kappaB in B cells", "ER-Phagosome pathway", "NOD1/2 Signaling Pathway", "TICAM1, RIP1-mediated IKK complex recruitment ", "RIP-mediated NFkB activation via ZBP1", "AKT phosphorylates targets in the cytosol", "Downstream TCR signaling", "FCERI mediated NF-kB activation", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "IKBKB deficiency causes SCID", "IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)", "IkBA variant leads to EDA-ID", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Constitutive Signaling by AKT1 E17K in Cancer", "NIK-->noncanonical NF-kB signaling", "MAP3K8 (TPL2)-dependent MAPK1/3 activation", "Interleukin-1 signaling", "TRAF6 mediated NF-kB activation", "NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10", "IRAK1 recruits IKK complex", "IKK complex recruitment mediated by RIP1", "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation"], "114757": ["eNOS activation", "Intracellular oxygen transport"], "114770": ["Antimicrobial peptides"], "114771": ["Antimicrobial peptides"], "114785": ["UCH proteinases"], "114787": ["MECP2 regulates neuronal receptors and channels"], "114790": ["Neutrophil degranulation"], "114791": ["Recruitment of mitotic centrosome proteins and complexes", "Recruitment of NuMA to mitotic centrosomes"], "114793": ["RHO GTPases Activate Formins"], "114798": ["Receptor-type tyrosine-protein phosphatases"], "114799": ["Establishment of Sister Chromatid Cohesion"], "114803": ["Metalloprotease DUBs"], "114805": ["O-linked glycosylation of mucins"], "114822": ["RHO GTPases Activate Rhotekin and Rhophilins", "RHO GTPases Activate Rhotekin and Rhophilins"], "114836": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "114876": ["Synthesis of bile acids and bile salts", "MHC class II antigen presentation"], "114879": ["Acyl chain remodelling of PS"], "114880": ["Synthesis of bile acids and bile salts"], "114881": ["Synthesis of bile acids and bile salts"], "114882": ["Acyl chain remodelling of PS"], "114883": ["Synthesis of bile acids and bile salts"], "114884": ["Acyl chain remodelling of PS"], "1149": ["Lipid particle organization"], "114907": ["Neddylation", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "Antigen processing: Ubiquitination & Proteasome degradation"], "114971": ["Synthesis of PG"], "115": ["Glucagon signaling in metabolic regulation", "PKA activation", "PKA activation in glucagon signalling", "Adenylate cyclase activating pathway", "Adenylate cyclase inhibitory pathway", "Adenylate cyclase inhibitory pathway", "G alpha (s) signalling events", "G alpha (s) signalling events", "G alpha (i) signalling events", "G alpha (z) signalling events", "G alpha (z) signalling events", "Vasopressin regulates renal water homeostasis via Aquaporins", "Hedgehog 'off' state"], "115004": ["STING mediated induction of host immune responses"], "115019": ["Multifunctional anion exchangers"], "115024": ["mRNA decay by 3' to 5' exoribonuclease"], "115106": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "115111": ["Multifunctional anion exchangers"], "115196": ["Generic Transcription Pathway"], "1152": ["Creatine metabolism"], "115201": ["Macroautophagy"], "115209": ["Regulation of Apoptosis"], "115273": ["RAB geranylgeranylation"], "115286": ["Transport of inorganic cations/anions and amino acids/oligopeptides"], "115290": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "115361": ["Interferon gamma signaling"], "115362": ["Interferon gamma signaling"], "1154": ["Interleukin-7 signaling", "Neddylation", "Growth hormone receptor signaling"], "115426": ["SUMOylation of transcription cofactors"], "1155": ["Post-chaperonin tubulin folding pathway"], "115509": ["Generic Transcription Pathway"], "115548": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "115557": ["G alpha (q) signalling events"], "115584": ["Inositol transporters"], "115650": ["TNFR2 non-canonical NF-kB pathway", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "115677": ["NOSTRIN mediated eNOS trafficking"], "115703": ["Rho GTPase cycle"], "115708": ["tRNA modification in the nucleus and cytosol"], "115727": ["FCERI mediated NF-kB activation", "RAF/MAP kinase cascade"], "1158": ["Creatine metabolism"], "115827": ["RAB geranylgeranylation"], "1159": ["Creatine metabolism"], "115939": ["rRNA modification in the nucleus and cytosol"], "116": ["NGF-independant TRKA activation", "G alpha (s) signalling events", "Glucagon-type ligand receptors"], "1160": ["Creatine metabolism"], "116028": ["HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Regulation of TP53 Activity through Phosphorylation", "G2/M DNA damage checkpoint"], "116085": ["Organic anion transport", "Defective SLC22A12 causes renal hypouricemia 1 (RHUC1)"], "1161": ["Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Neddylation"], "116138": ["XBP1(S) activates chaperone genes"], "116150": ["Synthesis of Dolichyl-phosphate"], "116228": ["TP53 Regulates Metabolic Genes", "Respiratory electron transport"], "116255": ["Triglyceride biosynthesis"], "116285": ["Conjugation of benzoate with glycine", "Conjugation of phenylacetate with glutamine"], "1163": ["SCF(Skp2)-mediated degradation of p27/p21", "Cyclin D associated events in G1"], "116372": ["Post-translational modification: synthesis of GPI-anchored proteins"], "116379": ["Interleukin-20 family signaling"], "116442": ["RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "116461": ["tRNA processing in the nucleus"], "116519": ["PPARA activates gene expression", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation", "Assembly of active LPL and LIPC lipase complexes", "Chylomicron remodeling"], "116540": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "116541": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "116832": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "116835": ["Regulation of HSF1-mediated heat shock response"], "116842": ["Antimicrobial peptides"], "116844": ["Neutrophil degranulation"], "116984": ["Rho GTPase cycle"], "116985": ["Rho GTPase cycle", "PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1"], "116986": ["Netrin-1 signaling"], "117": ["NGF-independant TRKA activation", "G alpha (s) signalling events", "Glucagon-type ligand receptors"], "117143": ["HATs acetylate histones"], "117144": ["Sperm Motility And Taxes"], "117145": ["PIP3 activates AKT signaling", "Activation of AKT2", "Negative regulation of the PI3K/AKT network", "CD28 dependent PI3K/Akt signaling", "VEGFR2 mediated vascular permeability", "Mitochondrial Fatty Acid Beta-Oxidation"], "117155": ["Sperm Motility And Taxes"], "117156": ["Scavenging by Class A Receptors", "Scavenging by Class A Receptors"], "117157": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "117159": ["Antimicrobial peptides"], "117177": ["Anchoring of the basal body to the plasma membrane", "VxPx cargo-targeting to cilium", "BBSome-mediated cargo-targeting to cilium", "RAB GEFs exchange GTP for GDP on RABs"], "117245": ["Acyl chain remodelling of PE"], "117246": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "117247": ["Amino acid transport across the plasma membrane"], "117248": ["O-linked glycosylation of mucins"], "117283": ["Synthesis of pyrophosphates in the cytosol"], "117285": ["Beta defensins", "Defensins"], "117289": ["Rho GTPase cycle"], "1173": ["Nef mediated downregulation of CD28 cell surface expression", "Nef Mediated CD4 Down-regulation", "Retrograde neurotrophin signalling", "Retrograde neurotrophin signalling", "Nef Mediated CD8 Down-regulation", "Gap junction degradation", "Formation of annular gap junctions", "MHC class II antigen presentation", "EPH-ephrin mediated repulsion of cells", "Trafficking of GluR2-containing AMPA receptors", "Recycling pathway of L1", "Recycling pathway of L1", "WNT5A-dependent internalization of FZD4", "WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "VLDLR internalisation and degradation", "LDL clearance"], "1174": ["Nef mediated downregulation of MHC class I complex cell surface expression", "MHC class II antigen presentation", "Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis"], "1175": ["Nef Mediated CD4 Down-regulation", "Retrograde neurotrophin signalling", "Retrograde neurotrophin signalling", "Nef Mediated CD8 Down-regulation", "MHC class II antigen presentation", "EPH-ephrin mediated repulsion of cells", "Trafficking of GluR2-containing AMPA receptors", "Recycling pathway of L1", "Recycling pathway of L1", "WNT5A-dependent internalization of FZD4", "WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "VLDLR internalisation and degradation", "LDL clearance"], "117579": ["G alpha (s) signalling events", "G alpha (i) signalling events", "Relaxin receptors"], "117581": ["Transcriptional regulation by RUNX2"], "117584": ["Regulation of TP53 Degradation"], "1176": ["Golgi Associated Vesicle Biogenesis"], "117608": ["Generic Transcription Pathway"], "117854": ["Interferon gamma signaling"], "1179": ["Stimuli-sensing channels"], "118": ["Caspase-mediated cleavage of cytoskeletal proteins", "XBP1(S) activates chaperone genes", "Miscellaneous transport and binding events"], "1180": ["Stimuli-sensing channels"], "1181": ["Stimuli-sensing channels"], "1182": ["Stimuli-sensing channels"], "1183": ["Stimuli-sensing channels"], "1184": ["Stimuli-sensing channels"], "118424": ["E3 ubiquitin ligases ubiquitinate target proteins", "Antigen processing: Ubiquitination & Proteasome degradation"], "118429": ["Uptake and function of anthrax toxins"], "118430": ["Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)", "Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)", "Defective GALNT12 causes colorectal cancer 1 (CRCS1)", "Dectin-2 family", "O-linked glycosylation of mucins", "Termination of O-glycan biosynthesis"], "118460": ["ATF4 activates genes", "mRNA decay by 3' to 5' exoribonuclease", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "KSRP (KHSRP) binds and destabilizes mRNA", "Major pathway of rRNA processing in the nucleolus and cytosol"], "118487": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "1185": ["Stimuli-sensing channels", "Signaling by BRAF and RAF fusions"], "1186": ["Stimuli-sensing channels"], "118672": ["Selenocysteine synthesis"], "1187": ["Stimuli-sensing channels"], "118788": ["PIP3 activates AKT signaling", "Constitutive Signaling by Aberrant PI3K in Cancer", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "1188": ["Stimuli-sensing channels"], "119": ["Miscellaneous transport and binding events"], "1191": ["Platelet degranulation ", "Terminal pathway of complement", "Antimicrobial peptides", "Regulation of Complement cascade"], "1193": ["Stimuli-sensing channels", "Ion homeostasis"], "119391": ["Glutathione conjugation", "Vitamin C (ascorbate) metabolism"], "119504": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6"], "119548": ["Digestion of dietary lipid"], "119678": ["Olfactory Signaling Pathway"], "119679": ["Olfactory Signaling Pathway"], "119682": ["Olfactory Signaling Pathway"], "119687": ["Olfactory Signaling Pathway"], "119692": ["Olfactory Signaling Pathway"], "119694": ["Olfactory Signaling Pathway"], "119695": ["Olfactory Signaling Pathway"], "119749": ["Olfactory Signaling Pathway"], "119764": ["Olfactory Signaling Pathway"], "119765": ["Olfactory Signaling Pathway"], "119772": ["Olfactory Signaling Pathway"], "119774": ["Olfactory Signaling Pathway"], "12": ["Platelet degranulation ", "Neutrophil degranulation"], "120": ["Miscellaneous transport and binding events"], "1200": ["XBP1(S) activates chaperone genes"], "120065": ["Olfactory Signaling Pathway"], "120066": ["Olfactory Signaling Pathway"], "120071": ["O-linked glycosylation"], "120103": ["Amino acid transport across the plasma membrane", "Tryptophan catabolism"], "120227": ["Vitamin D (calciferol) metabolism", "Vitamins", "Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B)"], "120425": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall"], "120526": ["Synthesis of diphthamide-EEF2"], "120586": ["Olfactory Signaling Pathway"], "1207": ["snRNP Assembly"], "120775": ["Olfactory Signaling Pathway"], "120776": ["Olfactory Signaling Pathway"], "120787": ["Olfactory Signaling Pathway"], "120793": ["Olfactory Signaling Pathway"], "120796": ["Olfactory Signaling Pathway"], "1208": ["Digestion of dietary lipid", "Retinoid metabolism and transport"], "120892": ["PTK6 promotes HIF1A stabilization"], "1211": ["Entry of Influenza Virion into Host Cell via Endocytosis", "Retrograde neurotrophin signalling", "Retrograde neurotrophin signalling", "Gap junction degradation", "Formation of annular gap junctions", "MHC class II antigen presentation", "EPH-ephrin mediated repulsion of cells", "Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis", "Recycling pathway of L1", "Recycling pathway of L1", "WNT5A-dependent internalization of FZD4", "WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "VLDLR internalisation and degradation", "LDL clearance"], "121129": ["Olfactory Signaling Pathway"], "121130": ["Olfactory Signaling Pathway"], "1212": ["Gap junction degradation", "Formation of annular gap junctions", "EPH-ephrin mediated repulsion of cells", "Lysosome Vesicle Biogenesis", "WNT5A-dependent internalization of FZD4", "WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "121214": ["The canonical retinoid cycle in rods (twilight vision)"], "121260": ["Proton/oligopeptide cotransporters", "Neutrophil degranulation"], "121274": ["Generic Transcription Pathway"], "121275": ["Olfactory Signaling Pathway"], "121278": ["Serotonin and melatonin biosynthesis"], "1213": ["Entry of Influenza Virion into Host Cell via Endocytosis", "Retrograde neurotrophin signalling", "Retrograde neurotrophin signalling", "Gap junction degradation", "Formation of annular gap junctions", "MHC class II antigen presentation", "EPH-ephrin mediated repulsion of cells", "Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis", "Recycling pathway of L1", "Recycling pathway of L1", "WNT5A-dependent internalization of FZD4", "WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "VLDLR internalisation and degradation", "LDL clearance"], "121340": ["RUNX2 regulates osteoblast differentiation"], "121364": ["Olfactory Signaling Pathway"], "121391": ["Keratinization", "Formation of the cornified envelope"], "121441": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "1215": ["Signaling by SCF-KIT", "Activation of Matrix Metalloproteinases", "Metabolism of Angiotensinogen to Angiotensins"], "121504": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "SUMOylation of chromatin organization proteins", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "121512": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "121536": ["PRC2 methylates histones and DNA", "PKMTs methylate histone lysines"], "121601": ["Stimuli-sensing channels"], "121642": ["ALKBH2 mediated reversal of alkylation damage"], "122042": ["G alpha (s) signalling events", "Relaxin receptors"], "122402": ["PIWI-interacting RNA (piRNA) biogenesis"], "122416": ["Neddylation"], "122481": ["Interconversion of nucleotide di- and triphosphates"], "122553": ["COPII-mediated vesicle transport", "RAB GEFs exchange GTP for GDP on RABs"], "122618": ["Synthesis of PG", "Synthesis of IP3 and IP4 in the cytosol", "Role of phospholipids in phagocytosis"], "122622": ["Purine ribonucleoside monophosphate biosynthesis"], "122665": ["Antimicrobial peptides"], "122704": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "122706": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "122740": ["Olfactory Signaling Pathway"], "122742": ["Olfactory Signaling Pathway"], "122748": ["Olfactory Signaling Pathway"], "122769": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "122809": ["RUNX1 regulates transcription of genes involved in differentiation of keratinocytes"], "122830": ["Retrograde transport at the Trans-Golgi-Network"], "122876": ["Hormone ligand-binding receptors", "G alpha (s) signalling events"], "122961": ["Mitochondrial iron-sulfur cluster biogenesis"], "122970": ["Beta-oxidation of very long chain fatty acids", "Peroxisomal protein import", "Peroxisomal protein import"], "123": ["PPARA activates gene expression"], "1230": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events", "Interleukin-10 signaling"], "123016": ["BBSome-mediated cargo-targeting to cilium"], "123041": ["Sodium/Calcium exchangers", "Defective SLC24A4 causes hypomineralized amelogenesis imperfecta (AI)"], "123096": ["Amino acid transport across the plasma membrane"], "123099": ["Sphingolipid de novo biosynthesis"], "123169": ["Formation of RNA Pol II elongation complex ", "Formation of the beta-catenin:TCF transactivating complex", "RNA Polymerase II Pre-transcription Events", "RNA Polymerase II Transcription Elongation", "E3 ubiquitin ligases ubiquitinate target proteins"], "1232": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "123228": ["UCH proteinases", "Neddylation"], "123263": ["Mitochondrial translation initiation"], "1233": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "1234": ["Binding and entry of HIV virion", "Chemokine receptors bind chemokines", "G alpha (i) signalling events", "Interleukin-10 signaling"], "1235": ["Beta defensins", "Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "1236": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "123606": ["Miscellaneous transport and binding events"], "123688": ["Lysine catabolism"], "1237": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "123745": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PS", "Acyl chain remodelling of PE", "Acyl chain remodelling of PI", "Hydrolysis of LPC"], "123876": ["Conjugation of salicylate with glycine"], "123879": ["Neddylation"], "123904": ["Post-translational modification: synthesis of GPI-anchored proteins"], "124": ["Abacavir metabolism", "RA biosynthesis pathway", "Ethanol oxidation"], "1240": ["Class A/1 (Rhodopsin-like receptors)"], "124056": ["RHO GTPases Activate NADPH Oxidases"], "1241": ["Leukotriene receptors", "G alpha (q) signalling events"], "1244": ["ABC-family proteins mediated transport", "Defective ABCC2 causes Dubin-Johnson syndrome"], "124411": ["Generic Transcription Pathway"], "124446": ["TP53 Regulates Transcription of Death Receptors and Ligands"], "124454": ["Mitochondrial tRNA aminoacylation"], "124538": ["Olfactory Signaling Pathway"], "124583": ["Neutrophil degranulation"], "124599": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "DAP12 interactions"], "124602": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "124739": ["Termination of translesion DNA synthesis"], "124872": ["Asparagine N-linked glycosylation"], "124935": ["Amino acid transport across the plasma membrane"], "124975": ["Glutathione synthesis and recycling", "Aflatoxin activation and detoxification"], "124995": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "125": ["Ethanol oxidation"], "125058": ["TBC/RABGAPs"], "125061": ["Tryptophan catabolism"], "125111": ["Gap junction assembly"], "125115": ["Keratinization", "Formation of the cornified envelope"], "125206": ["Cellular hexose transport"], "1253480": ["The IPAF inflammasome", "The IPAF inflammasome"], "1254294": ["The IPAF inflammasome", "The IPAF inflammasome"], "1254395": ["The IPAF inflammasome", "The IPAF inflammasome"], "125476": ["UCH proteinases", "DNA Damage Recognition in GG-NER"], "1258": ["Activation of the phototransduction cascade", "Inactivation, recovery and regulation of the phototransduction cascade", "VxPx cargo-targeting to cilium", "VxPx cargo-targeting to cilium"], "1259": ["Activation of the phototransduction cascade", "Inactivation, recovery and regulation of the phototransduction cascade"], "125919": ["Generic Transcription Pathway"], "125958": ["Olfactory Signaling Pathway"], "125962": ["Olfactory Signaling Pathway"], "125963": ["Olfactory Signaling Pathway"], "125981": ["Sphingolipid de novo biosynthesis"], "125988": ["Cristae formation"], "126": ["RA biosynthesis pathway", "Ethanol oxidation"], "1260": ["VxPx cargo-targeting to cilium", "VxPx cargo-targeting to cilium"], "126003": ["COPII-mediated vesicle transport", "RAB GEFs exchange GTP for GDP on RABs"], "126006": ["G alpha (i) signalling events"], "126014": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation"], "126068": ["Generic Transcription Pathway"], "126070": ["Generic Transcription Pathway"], "126119": ["Josephin domain DUBs"], "126123": ["Sperm:Oocyte Membrane Binding"], "1262": ["VxPx cargo-targeting to cilium", "VxPx cargo-targeting to cilium"], "126231": ["Generic Transcription Pathway"], "126282": ["PI Metabolism"], "1263": ["TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "Regulation of TP53 Activity through Phosphorylation"], "126328": ["Respiratory electron transport", "Complex I biogenesis"], "126370": ["Olfactory Signaling Pathway"], "126374": ["Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"], "126375": ["Generic Transcription Pathway"], "126382": ["Nuclear Receptor transcription pathway"], "126410": ["Fatty acids", "Miscellaneous substrates", "Eicosanoids", "Synthesis of Leukotrienes (LT) and Eoxins (EX)", "Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5)"], "126432": ["RAB GEFs exchange GTP for GDP on RABs"], "126433": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "1265": ["Neutrophil degranulation", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "126541": ["Olfactory Signaling Pathway"], "126638": ["Formation of the cornified envelope"], "126792": ["A tetrasaccharide linker sequence is required for GAG synthesis", "Defective B3GALT6 causes EDSP2 and SEMDJL1"], "1268": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (i) signalling events"], "1269": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (i) signalling events"], "126961": ["Interleukin-7 signaling", "Interleukin-7 signaling", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "HDACs deacetylate histones", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "Chromatin modifying enzymes", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation", "Factors involved in megakaryocyte development and platelet production"], "126969": ["Synthesis of PC", "Transport of bile salts and organic acids, metal ions and amine compounds"], "127": ["RA biosynthesis pathway", "Ethanol oxidation"], "1270": ["IL-6-type cytokine receptor ligand interactions"], "127059": ["Olfactory Signaling Pathway"], "127062": ["Olfactory Signaling Pathway"], "127064": ["Olfactory Signaling Pathway"], "127066": ["Olfactory Signaling Pathway"], "127068": ["Olfactory Signaling Pathway"], "127069": ["Olfactory Signaling Pathway"], "127074": ["Olfactory Signaling Pathway"], "127077": ["Olfactory Signaling Pathway"], "1271": ["IL-6-type cytokine receptor ligand interactions"], "127124": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "1272": ["Activated NOTCH1 Transmits Signal to the Nucleus", "NOTCH2 Activation and Transmission of Signal to the Nucleus", "L1CAM interactions", "Neurofascin interactions"], "127247": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "127253": ["Synthesis of wybutosine at G37 of tRNA(Phe)"], "127281": ["Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"], "127385": ["Olfactory Signaling Pathway"], "127396": ["Generic Transcription Pathway"], "127534": ["Gap junction assembly"], "127544": ["Antigen processing: Ubiquitination & Proteasome degradation"], "127623": ["Olfactory Signaling Pathway"], "1277": ["GPVI-mediated activation cascade", "Collagen degradation", "Collagen degradation", "Extracellular matrix organization", "Collagen biosynthesis and modifying enzymes", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Assembly of collagen fibrils and other multimeric structures", "Cell surface interactions at the vascular wall", "Integrin cell surface interactions", "Integrin cell surface interactions", "Anchoring fibril formation", "Crosslinking of collagen fibrils", "Syndecan interactions", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "ECM proteoglycans", "Scavenging by Class A Receptors", "GP1b-IX-V activation signalling", "Platelet Adhesion to exposed collagen", "Platelet Adhesion to exposed collagen", "Platelet Aggregation (Plug Formation)", "MET activates PTK2 signaling", "RUNX2 regulates osteoblast differentiation", "Collagen chain trimerization"], "1278": ["GPVI-mediated activation cascade", "Collagen degradation", "Collagen degradation", "Extracellular matrix organization", "Collagen biosynthesis and modifying enzymes", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Assembly of collagen fibrils and other multimeric structures", "Cell surface interactions at the vascular wall", "Integrin cell surface interactions", "Integrin cell surface interactions", "Anchoring fibril formation", "Crosslinking of collagen fibrils", "Syndecan interactions", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "ECM proteoglycans", "Scavenging by Class A Receptors", "GP1b-IX-V activation signalling", "Interleukin-4 and Interleukin-13 signaling", "Platelet Adhesion to exposed collagen", "Platelet Adhesion to exposed collagen", "Platelet Aggregation (Plug Formation)", "MET activates PTK2 signaling", "Collagen chain trimerization"], "127829": ["Neutrophil degranulation"], "127833": ["Toxicity of botulinum toxin type B (BoNT/B)", "Neurexins and neuroligins", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "128": ["Ethanol oxidation"], "1280": ["Collagen degradation", "Collagen degradation", "Extracellular matrix organization", "Collagen biosynthesis and modifying enzymes", "Signaling by PDGF", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "Integrin cell surface interactions", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "ECM proteoglycans", "NCAM1 interactions", "MET activates PTK2 signaling", "Collagen chain trimerization"], "1281": ["Collagen degradation", "Collagen degradation", "Extracellular matrix organization", "Collagen biosynthesis and modifying enzymes", "Signaling by PDGF", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "Syndecan interactions", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "ECM proteoglycans", "Scavenging by Class A Receptors", "NCAM1 interactions", "MET activates PTK2 signaling", "Collagen chain trimerization"], "128178": ["TNFs bind their physiological receptors"], "1282": ["Collagen degradation", "Collagen degradation", "Extracellular matrix organization", "Collagen biosynthesis and modifying enzymes", "Signaling by PDGF", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "Integrin cell surface interactions", "Anchoring fibril formation", "Crosslinking of collagen fibrils", "Laminin interactions", "Laminin interactions", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "Scavenging by Class A Receptors", "NCAM1 interactions", "Collagen chain trimerization"], "128239": ["RHO GTPases activate IQGAPs"], "128240": ["Nicotinamide salvaging"], "128272": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "128308": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "128312": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "HATs acetylate histones", "HATs acetylate histones", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Ub-specific processing proteases", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "128360": ["Olfactory Signaling Pathway"], "128366": ["Olfactory Signaling Pathway"], "128367": ["Olfactory Signaling Pathway"], "128368": ["Olfactory Signaling Pathway"], "128371": ["Olfactory Signaling Pathway"], "128372": ["Olfactory Signaling Pathway"], "1284": ["Collagen degradation", "Collagen degradation", "Extracellular matrix organization", "Collagen biosynthesis and modifying enzymes", "Signaling by PDGF", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "Integrin cell surface interactions", "Anchoring fibril formation", "Crosslinking of collagen fibrils", "Laminin interactions", "Laminin interactions", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "Scavenging by Class A Receptors", "NCAM1 interactions", "Collagen chain trimerization"], "128486": ["Lipid particle organization"], "1285": ["Collagen degradation", "Collagen degradation", "Extracellular matrix organization", "Collagen biosynthesis and modifying enzymes", "Signaling by PDGF", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "Integrin cell surface interactions", "Anchoring fibril formation", "Crosslinking of collagen fibrils", "Laminin interactions", "Laminin interactions", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "NCAM1 interactions", "Collagen chain trimerization"], "1286": ["Collagen degradation", "Collagen degradation", "Extracellular matrix organization", "Collagen biosynthesis and modifying enzymes", "Signaling by PDGF", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "Integrin cell surface interactions", "Anchoring fibril formation", "Crosslinking of collagen fibrils", "Laminin interactions", "Laminin interactions", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "NCAM1 interactions", "Collagen chain trimerization"], "128637": ["COPII-mediated vesicle transport", "TBC/RABGAPs"], "128674": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "1287": ["Collagen degradation", "Collagen degradation", "Extracellular matrix organization", "Collagen biosynthesis and modifying enzymes", "Signaling by PDGF", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "Integrin cell surface interactions", "Anchoring fibril formation", "Crosslinking of collagen fibrils", "Laminin interactions", "Laminin interactions", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "NCAM1 interactions", "Collagen chain trimerization", "Regulation of expression of SLITs and ROBOs"], "1288": ["Collagen degradation", "Collagen degradation", "Extracellular matrix organization", "Collagen biosynthesis and modifying enzymes", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "Integrin cell surface interactions", "Anchoring fibril formation", "Crosslinking of collagen fibrils", "Laminin interactions", "Laminin interactions", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "Collagen chain trimerization"], "128859": ["Antimicrobial peptides"], "128866": ["Budding and maturation of HIV virion", "Macroautophagy", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "128869": ["Attachment of GPI anchor to uPAR"], "1289": ["Collagen degradation", "Extracellular matrix organization", "Collagen biosynthesis and modifying enzymes", "Signaling by PDGF", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "Syndecan interactions", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "NCAM1 interactions", "MET activates PTK2 signaling", "Collagen chain trimerization"], "1290": ["Collagen degradation", "Extracellular matrix organization", "Collagen biosynthesis and modifying enzymes", "Signaling by PDGF", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "Syndecan interactions", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "NCAM1 interactions", "MET activates PTK2 signaling", "Collagen chain trimerization"], "1291": ["Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Signaling by PDGF", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "ECM proteoglycans", "ECM proteoglycans", "NCAM1 interactions", "Collagen chain trimerization"], "1292": ["Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Signaling by PDGF", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "ECM proteoglycans", "ECM proteoglycans", "NCAM1 interactions", "Collagen chain trimerization"], "1293": ["Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Signaling by PDGF", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "ECM proteoglycans", "ECM proteoglycans", "NCAM1 interactions", "Collagen chain trimerization"], "1294": ["Collagen degradation", "Collagen degradation", "Extracellular matrix organization", "Collagen biosynthesis and modifying enzymes", "Assembly of collagen fibrils and other multimeric structures", "COPII-mediated vesicle transport", "Integrin cell surface interactions", "Anchoring fibril formation", "Laminin interactions", "Laminin interactions", "Cargo concentration in the ER", "Collagen chain trimerization"], "129401": ["ISG15 antiviral mechanism", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "tRNA processing in the nucleus"], "129450": ["Synthesis of wybutosine at G37 of tRNA(Phe)"], "1295": ["Collagen degradation", "Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "Collagen chain trimerization"], "129521": ["Peptide ligand-binding receptors", "G alpha (q) signalling events", "G alpha (i) signalling events"], "1296": ["Collagen degradation", "Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "Collagen chain trimerization"], "129642": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PE"], "129685": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes"], "1297": ["Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Signaling by PDGF", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "ECM proteoglycans", "NCAM1 interactions", "Collagen chain trimerization"], "1298": ["Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Signaling by PDGF", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "ECM proteoglycans", "NCAM1 interactions", "Collagen chain trimerization"], "129807": ["Glycosphingolipid metabolism", "Sialic acid metabolism"], "129880": ["BBSome-mediated cargo-targeting to cilium"], "1299": ["Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Signaling by PDGF", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "ECM proteoglycans", "NCAM1 interactions", "Collagen chain trimerization"], "13": ["Phase I - Functionalization of compounds"], "130": ["Ethanol oxidation"], "1300": ["Collagen degradation", "Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "Non-integrin membrane-ECM interactions", "Collagen chain trimerization"], "130013": ["Tryptophan catabolism"], "130075": ["Olfactory Signaling Pathway"], "1301": ["Collagen degradation", "Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Assembly of collagen fibrils and other multimeric structures", "Non-integrin membrane-ECM interactions", "MET activates PTK2 signaling", "Collagen chain trimerization"], "130120": ["Antimicrobial peptides"], "1302": ["Collagen degradation", "Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Assembly of collagen fibrils and other multimeric structures", "Non-integrin membrane-ECM interactions", "MET activates PTK2 signaling", "Collagen chain trimerization"], "1303": ["Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Assembly of collagen fibrils and other multimeric structures", "Collagen chain trimerization"], "130340": ["Nef mediated downregulation of MHC class I complex cell surface expression", "MHC class II antigen presentation", "Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis"], "130367": ["Sphingolipid de novo biosynthesis"], "130399": ["Signaling by NODAL", "Regulation of signaling by NODAL", "Signaling by Activin", "Signaling by Activin"], "1305": ["Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Integrin cell surface interactions", "Collagen chain trimerization"], "130576": ["Post-translational modification: synthesis of GPI-anchored proteins"], "1306": ["Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Assembly of collagen fibrils and other multimeric structures", "Collagen chain trimerization"], "1307": ["Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Integrin cell surface interactions", "Collagen chain trimerization"], "1308": ["Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Assembly of collagen fibrils and other multimeric structures", "Type I hemidesmosome assembly", "Collagen chain trimerization"], "130916": ["rRNA modification in the mitochondrion"], "131": ["Ethanol oxidation"], "1310": ["Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Collagen chain trimerization"], "131096": ["Voltage gated Potassium channels"], "1311": ["Integrin cell surface interactions", "ECM proteoglycans"], "131118": ["Mitochondrial protein import"], "1312": ["Methylation", "Enzymatic degradation of dopamine by COMT", "Enzymatic degradation of Dopamine by monoamine oxidase"], "1314": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "131405": ["Antigen processing: Ubiquitination & Proteasome degradation"], "131450": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "131474": ["Mitochondrial protein import"], "1315": ["Neutrophil degranulation", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "131669": ["Histidine catabolism"], "1317": ["Metal ion SLC transporters"], "131870": ["Phosphate bond hydrolysis by NUDT proteins"], "131873": ["Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Signaling by PDGF", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "ECM proteoglycans", "ECM proteoglycans", "NCAM1 interactions", "Collagen chain trimerization"], "131890": ["Inactivation, recovery and regulation of the phototransduction cascade"], "132": ["Purine salvage"], "132014": ["Interleukin-17 signaling"], "132112": ["Olfactory Signaling Pathway"], "132158": ["Fructose catabolism"], "132320": ["Anchoring of the basal body to the plasma membrane"], "1325": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "1326": ["CD28 dependent PI3K/Akt signaling", "MAP3K8 (TPL2)-dependent MAPK1/3 activation", "MAP3K8 (TPL2)-dependent MAPK1/3 activation"], "132660": ["Transcription of E2F targets under negative control by DREAM complex", "Transcription of E2F targets under negative control by DREAM complex", "Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1", "G0 and Early G1", "Polo-like kinase mediated events", "Activation of E2F1 target genes at G1/S", "Cyclin E associated events during G1/S transition ", "Cyclin A:Cdk2-associated events at S phase entry"], "1327": ["TP53 Regulates Metabolic Genes", "Respiratory electron transport"], "132789": ["Glycolysis"], "132884": ["Hedgehog 'on' state", "Activation of SMO", "Activation of SMO"], "1329": ["TP53 Regulates Metabolic Genes", "Respiratory electron transport"], "133": ["G alpha (s) signalling events", "Calcitonin-like ligand receptors"], "133121": ["Glycerophospholipid catabolism"], "133308": ["Stimuli-sensing channels"], "133383": ["Regulation of TP53 Activity through Methylation"], "133396": ["IL-6-type cytokine receptor ligand interactions"], "133418": ["Proton-coupled monocarboxylate transport"], "133522": ["PPARA activates gene expression", "Transcriptional activation of mitochondrial biogenesis", "Transcriptional activation of mitochondrial biogenesis", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity"], "133686": ["Nicotinate metabolism"], "133688": ["Glucuronidation"], "1337": ["TP53 Regulates Metabolic Genes", "Respiratory electron transport"], "133746": ["Regulation of TP53 Activity through Methylation"], "134": ["Adenosine P1 receptors", "G alpha (i) signalling events"], "1340": ["TP53 Regulates Metabolic Genes", "Respiratory electron transport"], "134083": ["Olfactory Signaling Pathway"], "134147": ["Phase I - Functionalization of compounds"], "134266": ["Mitochondrial protein import"], "134353": ["Cleavage of Growing Transcript in the Termination Region ", "SLBP independent Processing of Histone Pre-mRNAs", "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"], "134429": ["Pregnenolone biosynthesis"], "134430": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "1345": ["TP53 Regulates Metabolic Genes", "Respiratory electron transport"], "134526": ["Mitochondrial Fatty Acid Beta-Oxidation"], "134637": ["tRNA modification in the nucleus and cytosol"], "134829": ["Lysosome Vesicle Biogenesis"], "134860": ["Amine ligand-binding receptors", "G alpha (s) signalling events"], "134864": ["Amine ligand-binding receptors", "G alpha (s) signalling events"], "1349": ["TP53 Regulates Metabolic Genes", "Respiratory electron transport"], "135": ["NGF-independant TRKA activation", "Adenosine P1 receptors", "G alpha (s) signalling events", "Surfactant metabolism"], "1350": ["TP53 Regulates Metabolic Genes", "Respiratory electron transport"], "1351": ["TP53 Regulates Metabolic Genes", "Respiratory electron transport"], "135152": ["A tetrasaccharide linker sequence is required for GAG synthesis"], "1352": ["Heme biosynthesis"], "135228": ["Platelet degranulation ", "Post-translational modification: synthesis of GPI-anchored proteins"], "135250": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "1353": ["TP53 Regulates Metabolic Genes", "Respiratory electron transport"], "1355": ["Heme biosynthesis"], "1356": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Metal ion SLC transporters", "Defective CP causes aceruloplasminemia (ACERULOP)", "Post-translational protein phosphorylation", "Iron uptake and transport"], "135892": ["Antigen processing: Ubiquitination & Proteasome degradation"], "1359": ["Metabolism of Angiotensinogen to Angiotensins"], "135924": ["Olfactory Signaling Pathway"], "135941": ["Olfactory Signaling Pathway"], "135946": ["Olfactory Signaling Pathway"], "135948": ["Olfactory Signaling Pathway"], "136": ["Adenosine P1 receptors", "G alpha (s) signalling events", "Surfactant metabolism"], "1360": ["Metabolism of Angiotensinogen to Angiotensins"], "136051": ["Generic Transcription Pathway"], "1361": ["Metabolism of Angiotensinogen to Angiotensins", "Regulation of Complement cascade"], "1362": ["Golgi Associated Vesicle Biogenesis"], "136227": ["Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Collagen chain trimerization"], "1363": ["Insulin processing"], "136371": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "1364": ["Tight junction interactions"], "1365": ["Tight junction interactions"], "1366": ["Tight junction interactions"], "1368": ["Post-translational modification: synthesis of GPI-anchored proteins"], "1369": ["Regulation of Complement cascade"], "136991": ["PIWI-interacting RNA (piRNA) biogenesis"], "1370": ["Regulation of Complement cascade"], "137075": ["Tight junction interactions"], "1371": ["Heme biosynthesis"], "1373": ["Urea cycle"], "1374": ["RORA activates gene expression", "PPARA activates gene expression", "Import of palmitoyl-CoA into the mitochondrial matrix", "Signaling by Retinoic Acid"], "137492": ["Budding and maturation of HIV virion", "Membrane binding and targetting of GAG proteins", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "1375": ["Import of palmitoyl-CoA into the mitochondrial matrix", "Signaling by Retinoic Acid"], "1376": ["PPARA activates gene expression", "Import of palmitoyl-CoA into the mitochondrial matrix"], "137682": ["Complex I biogenesis"], "137797": ["Post-translational modification: synthesis of GPI-anchored proteins"], "1378": ["Neutrophil degranulation", "RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "Regulation of Complement cascade"], "137872": ["Interconversion of 2-oxoglutarate and 2-hydroxyglutarate"], "137964": ["Synthesis of PA"], "137970": ["Netrin mediated repulsion signals"], "1380": ["Regulation of Complement cascade"], "138050": ["HS-GAG degradation", "MPS IIIC - Sanfilippo syndrome C", "Neutrophil degranulation"], "1381": ["RA biosynthesis pathway"], "138199": ["Histidine catabolism"], "1382": ["Signaling by Retinoic Acid"], "1384": ["Beta-oxidation of pristanoyl-CoA", "Peroxisomal protein import", "Peroxisomal protein import"], "138474": ["HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "1385": ["PKA-mediated phosphorylation of CREB", "CaMK IV-mediated phosphorylation of CREB", "AKT phosphorylates targets in the nucleus", "CREB phosphorylation", "Transcriptional activation of mitochondrial biogenesis", "Transcriptional activation of mitochondrial biogenesis", "NOTCH2 intracellular domain regulates transcription", "NCAM signaling for neurite out-growth", "Circadian Clock", "Circadian Clock", "CREB1 phosphorylation through the activation of Adenylate Cyclase", "CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling", "Constitutive Signaling by AKT1 E17K in Cancer", "Gastrin-CREB signalling pathway via PKC and MAPK", "Regulation of MECP2 expression and activity", "MECP2 regulates neuronal receptors and channels", "MECP2 regulates transcription of neuronal ligands", "MECP2 regulates transcription factors"], "1386": ["Transcriptional activation of mitochondrial biogenesis", "HATs acetylate histones", "Circadian Clock", "Activation of the AP-1 family of transcription factors", "TP53 Regulates Transcription of DNA Repair Genes", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription", "Estrogen-dependent gene expression"], "1387": ["Regulation of gene expression by Hypoxia-inducible Factor", "RORA activates gene expression", "BMAL1:CLOCK,NPAS2 activates circadian gene expression", "Pre-NOTCH Transcription and Translation", "Pre-NOTCH Transcription and Translation", "PPARA activates gene expression", "PPARA activates gene expression", "Formation of the beta-catenin:TCF transactivating complex", "Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "NOTCH1 Intracellular Domain Regulates Transcription", "NOTCH1 Intracellular Domain Regulates Transcription", "Transcriptional activation of mitochondrial biogenesis", "Activation of gene expression by SREBF (SREBP)", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "HATs acetylate histones", "Attenuation phase", "Notch-HLH transcription pathway", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation", "SUMOylation of transcription cofactors", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)", "Circadian Clock", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "CD209 (DC-SIGN) signaling", "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "Activation of the TFAP2 (AP-2) family of transcription factors", "RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "RUNX3 regulates NOTCH signaling", "RUNX3 regulates NOTCH signaling", "NOTCH3 Intracellular Domain Regulates Transcription", "NOTCH3 Intracellular Domain Regulates Transcription", "NOTCH4 Intracellular Domain Regulates Transcription", "Estrogen-dependent gene expression", "TRAF3-dependent IRF activation pathway", "TRAF6 mediated IRF7 activation", "FOXO-mediated transcription of cell death genes", "Regulation of FOXO transcriptional activity by acetylation", "Regulation of FOXO transcriptional activity by acetylation"], "138799": ["Olfactory Signaling Pathway"], "138802": ["Olfactory Signaling Pathway"], "138803": ["Olfactory Signaling Pathway"], "138804": ["Olfactory Signaling Pathway"], "138805": ["Olfactory Signaling Pathway"], "138881": ["Olfactory Signaling Pathway"], "138882": ["Olfactory Signaling Pathway"], "138883": ["Olfactory Signaling Pathway"], "1390": ["Circadian Clock"], "139065": ["Receptor-type tyrosine-protein phosphatases"], "139189": ["Effects of PIP2 hydrolysis"], "1392": ["Class B/2 (Secretin family receptors)", "G alpha (s) signalling events", "MECP2 regulates transcription of neuronal ligands"], "139285": ["Degradation of beta-catenin by the destruction complex", "Beta-catenin phosphorylation cascade", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Misspliced GSK3beta mutants stabilize beta-catenin", "S33 mutants of beta-catenin aren't phosphorylated", "S37 mutants of beta-catenin aren't phosphorylated", "S45 mutants of beta-catenin aren't phosphorylated", "T41 mutants of beta-catenin aren't phosphorylated", "APC truncation mutants have impaired AXIN binding", "AXIN missense mutants destabilize the destruction complex", "Truncations of AMER1 destabilize the destruction complex"], "1393": ["Class B/2 (Secretin family receptors)"], "139322": ["Platelet degranulation ", "Cristae formation"], "139341": ["Receptor Mediated Mitophagy"], "1394": ["Class B/2 (Secretin family receptors)", "G alpha (s) signalling events"], "1395": ["Class B/2 (Secretin family receptors)", "G alpha (s) signalling events", "Synthesis, secretion, and deacylation of Ghrelin"], "139760": ["Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)"], "1398": ["ARMS-mediated activation", "ARMS-mediated activation", "Downstream signal transduction", "Regulation of actin dynamics for phagocytic cup formation", "p130Cas linkage to MAPK signaling for integrins", "VEGFA-VEGFR2 Pathway", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "MET activates RAP1 and RAC1", "MET receptor recycling", "Regulation of signaling by CBL"], "139818": ["Factors involved in megakaryocyte development and platelet production"], "1399": ["Frs2-mediated activation", "Frs2-mediated activation", "Downstream signal transduction", "MET activates RAP1 and RAC1", "MET receptor recycling", "Erythropoietin activates RAS", "Erythropoietin activates RAS", "Regulation of signaling by CBL"], "140": ["Adenosine P1 receptors", "G alpha (i) signalling events"], "1400": ["CRMPs in Sema3A signaling"], "140032": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "1401": ["Classical antibody-mediated complement activation"], "140258": ["Keratinization"], "1404": ["ECM proteoglycans"], "140453": ["Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)", "Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)", "Defective GALNT12 causes colorectal cancer 1 (CRCS1)", "Dectin-2 family", "O-linked glycosylation of mucins", "Termination of O-glycan biosynthesis"], "140456": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "140458": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "140459": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "140460": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "140461": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "140462": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "140465": ["Smooth Muscle Contraction"], "140596": ["Beta defensins", "Defensins"], "140609": ["Activation of NIMA Kinases NEK9, NEK6, NEK7", "Nuclear Pore Complex (NPC) Disassembly"], "140612": ["Generic Transcription Pathway"], "140628": ["Factors involved in megakaryocyte development and platelet production"], "140679": ["Transport of inorganic cations/anions and amino acids/oligopeptides", "GABA synthesis, release, reuptake and degradation"], "140683": ["Antimicrobial peptides"], "140687": ["O-linked glycosylation of mucins"], "140691": ["Antigen processing: Ubiquitination & Proteasome degradation"], "1407": ["Circadian Clock"], "140735": ["Activation of BMF and translocation to mitochondria", "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Macroautophagy", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Intraflagellar transport", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase"], "140739": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "140766": ["Collagen biosynthesis and modifying enzymes", "Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "1408": ["Circadian Clock"], "140801": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "140803": ["TRP channels"], "140807": ["Keratinization", "Formation of the cornified envelope"], "140825": ["Neddylation"], "140838": ["Sialic acid metabolism"], "140850": ["Beta defensins", "Defensins"], "140881": ["Beta defensins", "Defensins"], "140885": ["Cell surface interactions at the vascular wall", "Signal regulatory protein family interactions", "Signal regulatory protein family interactions", "Neutrophil degranulation"], "1410": ["HSF1-dependent transactivation"], "142": ["POLB-Dependent Long Patch Base Excision Repair", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "SUMOylation of DNA damage response and repair proteins", "HDR through MMEJ (alt-NHEJ)", "DNA Damage Recognition in GG-NER", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER"], "142678": ["Activated NOTCH1 Transmits Signal to the Nucleus", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "NOTCH2 Activation and Transmission of Signal to the Nucleus", "NOTCH3 Activation and Transmission of Signal to the Nucleus", "Antigen processing: Ubiquitination & Proteasome degradation"], "142680": ["Type II Na+/Pi cotransporters", "Defective SLC34A3 causes Hereditary hypophosphatemic rickets with hypercalciuria (HHRH)"], "142684": ["RAB geranylgeranylation"], "142685": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "142686": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "142689": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "1428": ["Lysine catabolism"], "142827": ["Beta oxidation of butanoyl-CoA to acetyl-CoA"], "142891": ["Sphingolipid de novo biosynthesis"], "142910": ["Formation of the cornified envelope"], "143": ["Nicotinamide salvaging"], "1431": ["Mitochondrial protein import", "Citric acid cycle (TCA cycle)"], "143187": ["Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network"], "1432": ["NOD1/2 Signaling Pathway", "p38MAPK events", "p38MAPK events", "ERK/MAPK targets", "Activation of PPARGC1A (PGC-1alpha) by phosphorylation", "Oxidative Stress Induced Senescence", "CDO in myogenesis", "CDO in myogenesis", "DSCAM interactions", "ADP signalling through P2Y purinoceptor 1", "Platelet sensitization by LDL", "VEGFA-VEGFR2 Pathway", "activated TAK1 mediates p38 MAPK activation", "Activation of the AP-1 family of transcription factors", "KSRP (KHSRP) binds and destabilizes mRNA", "RHO GTPases Activate NADPH Oxidases", "Neutrophil degranulation", "Regulation of TP53 Activity through Phosphorylation"], "143279": ["Antigen processing: Ubiquitination & Proteasome degradation"], "143282": ["FGFR2b ligand binding and activation"], "143425": ["Neurexins and neuroligins", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "143471": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "1435": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Other interleukin signaling", "Interleukin-10 signaling", "Post-translational protein phosphorylation"], "143502": ["Olfactory Signaling Pathway"], "143503": ["Olfactory Signaling Pathway"], "1436": ["Other interleukin signaling"], "143662": ["Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)", "Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)", "Defective GALNT12 causes colorectal cancer 1 (CRCS1)", "Dectin-2 family", "O-linked glycosylation of mucins", "Termination of O-glycan biosynthesis"], "143686": ["TP53 Regulates Metabolic Genes"], "143689": ["PIWI-interacting RNA (piRNA) biogenesis"], "1437": ["Interleukin-3, Interleukin-5 and GM-CSF signaling", "RAF/MAP kinase cascade", "Interleukin-10 signaling", "RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "Interleukin receptor SHC signaling"], "1438": ["Interleukin-3, Interleukin-5 and GM-CSF signaling", "RAF/MAP kinase cascade", "Surfactant metabolism", "Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5)", "Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)", "Interleukin receptor SHC signaling"], "143872": ["Rho GTPase cycle"], "1439": ["Interleukin-3, Interleukin-5 and GM-CSF signaling", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "RAF/MAP kinase cascade", "Surfactant metabolism", "Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5)", "Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)", "Interleukin receptor SHC signaling"], "1440": ["Other interleukin signaling", "Interleukin-10 signaling"], "1441": ["Other interleukin signaling"], "144124": ["Olfactory Signaling Pathway"], "144125": ["Olfactory Signaling Pathway"], "144165": ["Asymmetric localization of PCP proteins"], "144193": ["Histidine catabolism"], "144195": ["Cellular hexose transport"], "1442": ["Prolactin receptor signaling", "Prolactin receptor signaling", "Growth hormone receptor signaling"], "144233": ["MicroRNA (miRNA) biogenesis"], "144245": ["Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"], "144348": ["Generic Transcription Pathway"], "144453": ["Stimuli-sensing channels"], "144455": ["TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest"], "1445": ["GAB1 signalosome", "Phosphorylation of CD3 and TCR zeta chains", "Integrin alphaIIb beta3 signaling", "PD-1 signaling", "MAP2K and MAPK activation", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF"], "144501": ["Keratinization", "Formation of the cornified envelope"], "1446": ["Miscellaneous transport and binding events"], "144699": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "1447": ["Nuclear signaling by ERBB4"], "144715": ["Activation of ATR in response to replication stress", "HDR through Single Strand Annealing (SSA)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Regulation of TP53 Activity through Phosphorylation", "G2/M DNA damage checkpoint"], "1448": ["Miscellaneous transport and binding events"], "145173": ["Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "1452": ["Degradation of beta-catenin by the destruction complex", "Beta-catenin phosphorylation cascade", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Misspliced GSK3beta mutants stabilize beta-catenin", "S33 mutants of beta-catenin aren't phosphorylated", "S37 mutants of beta-catenin aren't phosphorylated", "S45 mutants of beta-catenin aren't phosphorylated", "T41 mutants of beta-catenin aren't phosphorylated", "APC truncation mutants have impaired AXIN binding", "AXIN missense mutants destabilize the destruction complex", "Truncations of AMER1 destabilize the destruction complex", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Activation of SMO", "Activation of SMO"], "145226": ["Retinoid cycle disease events", "The canonical retinoid cycle in rods (twilight vision)"], "1453": ["COPII-mediated vesicle transport", "Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Circadian Clock", "Anchoring of the basal body to the plasma membrane", "Major pathway of rRNA processing in the nucleolus and cytosol", "AURKA Activation by TPX2"], "1454": ["WNT mediated activation of DVL", "Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Circadian Clock", "Anchoring of the basal body to the plasma membrane", "Major pathway of rRNA processing in the nucleolus and cytosol", "AURKA Activation by TPX2"], "145482": ["Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"], "1455": ["Sphingolipid de novo biosynthesis", "Disassembly of the destruction complex and recruitment of AXIN to the membrane"], "1457": ["Synthesis of PC", "WNT mediated activation of DVL", "Condensation of Prometaphase Chromosomes", "Signal transduction by L1", "Regulation of TP53 Activity through Phosphorylation", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "Receptor Mediated Mitophagy", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Regulation of PTEN stability and activity"], "1459": ["Synthesis of PC", "WNT mediated activation of DVL", "Condensation of Prometaphase Chromosomes", "Signal transduction by L1", "Regulation of TP53 Activity through Phosphorylation", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "Receptor Mediated Mitophagy", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Regulation of PTEN stability and activity"], "145957": ["Signaling by ERBB2", "Signaling by ERBB4", "SHC1 events in ERBB2 signaling", "SHC1 events in ERBB2 signaling", "PI3K events in ERBB4 signaling", "SHC1 events in ERBB4 signaling", "Nuclear signaling by ERBB4", "PIP3 activates AKT signaling", "GRB2 events in ERBB2 signaling", "PI3K events in ERBB2 signaling", "Constitutive Signaling by Aberrant PI3K in Cancer", "RAF/MAP kinase cascade", "ERBB2 Regulates Cell Motility", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "ERBB2 Activates PTK6 Signaling", "Downregulation of ERBB2 signaling"], "146": ["Adrenoceptors", "G alpha (q) signalling events", "G alpha (12/13) signalling events"], "1460": ["Synthesis of PC", "WNT mediated activation of DVL", "Condensation of Prometaphase Chromosomes", "Signal transduction by L1", "Neutrophil degranulation", "Regulation of TP53 Activity through Phosphorylation", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "Receptor Mediated Mitophagy", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Regulation of PTEN stability and activity"], "146057": ["Anchoring of the basal body to the plasma membrane"], "146183": ["Post-translational modification: synthesis of GPI-anchored proteins"], "146198": ["Generic Transcription Pathway"], "1462": ["A tetrasaccharide linker sequence is required for GAG synthesis", "Chondroitin sulfate biosynthesis", "Dermatan sulfate biosynthesis", "CS/DS degradation", "ECM proteoglycans", "Defective B4GALT7 causes EDS, progeroid type", "Defective B3GAT3 causes JDSSDHD", "Defective CHST3 causes SEDCJD", "Defective CHST14 causes EDS, musculocontractural type", "Defective CHSY1 causes TPBS", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Defective B3GALT6 causes EDSP2 and SEMDJL1", "Post-translational protein phosphorylation"], "1463": ["A tetrasaccharide linker sequence is required for GAG synthesis", "Chondroitin sulfate biosynthesis", "Dermatan sulfate biosynthesis", "CS/DS degradation", "ECM proteoglycans", "Defective B4GALT7 causes EDS, progeroid type", "Defective B3GAT3 causes JDSSDHD", "Defective CHST3 causes SEDCJD", "Defective CHST14 causes EDS, musculocontractural type", "Defective CHSY1 causes TPBS", "L1CAM interactions", "NCAM1 interactions", "Defective B3GALT6 causes EDSP2 and SEMDJL1"], "146330": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "1464": ["A tetrasaccharide linker sequence is required for GAG synthesis", "Chondroitin sulfate biosynthesis", "Dermatan sulfate biosynthesis", "CS/DS degradation", "Defective B4GALT7 causes EDS, progeroid type", "Defective B3GAT3 causes JDSSDHD", "Defective CHST3 causes SEDCJD", "Defective CHST14 causes EDS, musculocontractural type", "Defective CHSY1 causes TPBS", "Defective B3GALT6 causes EDSP2 and SEMDJL1"], "146433": ["Other interleukin signaling"], "146434": ["Generic Transcription Pathway"], "1465": ["MTF1 activates gene expression"], "146540": ["Generic Transcription Pathway"], "146542": ["Generic Transcription Pathway"], "146712": ["O-linked glycosylation of mucins"], "146722": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "146760": ["Post-translational modification: synthesis of GPI-anchored proteins"], "1468": ["Sulfide oxidation to sulfate", "Organic anion transporters", "Gluconeogenesis"], "146802": ["Transport of bile salts and organic acids, metal ions and amine compounds"], "146850": ["GPVI-mediated activation cascade", "Synthesis of PIPs at the plasma membrane", "G beta:gamma signalling through PI3Kgamma"], "146894": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "146909": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "146956": ["Resolution of D-loop Structures through Holliday Junction Intermediates", "Fanconi Anemia Pathway"], "147": ["Adrenoceptors", "G alpha (q) signalling events", "G alpha (12/13) signalling events"], "1471": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Neutrophil degranulation", "Post-translational protein phosphorylation", "Amyloid fiber formation"], "147111": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Release of Hh-Np from the secreting cell", "Post-translational protein phosphorylation"], "147179": ["Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs"], "147183": ["Keratinization", "Formation of the cornified envelope"], "147323": ["Pregnenolone biosynthesis"], "147409": ["Keratinization", "Formation of the cornified envelope"], "1475": ["Formation of the cornified envelope"], "1476": ["Neutrophil degranulation"], "147657": ["Generic Transcription Pathway"], "147686": ["Generic Transcription Pathway"], "147687": ["Generic Transcription Pathway"], "147694": ["Generic Transcription Pathway"], "1477": ["Cleavage of Growing Transcript in the Termination Region ", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "147700": ["MHC class II antigen presentation", "RHO GTPases activate KTN1", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "147719": ["Post-translational modification: synthesis of GPI-anchored proteins"], "147741": ["Generic Transcription Pathway"], "1478": ["Cleavage of Growing Transcript in the Termination Region ", "tRNA processing in the nucleus", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "147837": ["Generic Transcription Pathway"], "147841": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "1479": ["Cleavage of Growing Transcript in the Termination Region ", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "147923": ["Generic Transcription Pathway", "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release"], "147929": ["Generic Transcription Pathway"], "147945": ["IRF3 mediated activation of type 1 IFN", "Regulation of innate immune responses to cytosolic DNA", "IRF3-mediated induction of type I IFN"], "147948": ["Generic Transcription Pathway"], "147949": ["Generic Transcription Pathway"], "147968": ["Degradation of the extracellular matrix"], "148": ["Adrenoceptors", "G alpha (q) signalling events", "G alpha (12/13) signalling events"], "148022": ["Caspase activation via Death Receptors in the presence of ligand", "MyD88-independent TLR4 cascade ", "Toll Like Receptor 3 (TLR3) Cascade", "TICAM1, RIP1-mediated IKK complex recruitment ", "RIP-mediated NFkB activation via ZBP1", "TRIF-mediated programmed cell death", "TICAM1 deficiency - HSE", "TRAF3 deficiency - HSE", "TLR3-mediated TICAM1-dependent programmed cell death", "TICAM1-dependent activation of IRF3/IRF7", "TICAM1,TRAF6-dependent induction of TAK1 complex", "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon", "IKK complex recruitment mediated by RIP1", "TRAF6-mediated induction of TAK1 complex within TLR4 complex", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"], "148103": ["Generic Transcription Pathway"], "148156": ["Generic Transcription Pathway"], "148170": ["MAPK6/MAPK4 signaling"], "1482": ["YAP1- and WWTR1 (TAZ)-stimulated gene expression", "Physiological factors"], "148206": ["Generic Transcription Pathway"], "148213": ["Generic Transcription Pathway"], "148229": ["Ion transport by P-type ATPases"], "148254": ["Generic Transcription Pathway"], "148266": ["Generic Transcription Pathway"], "148268": ["Generic Transcription Pathway"], "148327": ["CREB3 factors activate genes"], "148581": ["Antigen processing: Ubiquitination & Proteasome degradation"], "1486086": ["CASP8 activity is inhibited", "Regulation of TNFR1 signaling"], "1487": ["Deactivation of the beta-catenin transactivating complex", "SUMOylation of transcription cofactors", "Repression of WNT target genes", "TCF7L2 mutants don't bind CTBP"], "1487017": ["Caspase activation via Death Receptors in the presence of ligand"], "148738": ["Netrin-1 signaling"], "148789": ["O-linked glycosylation"], "1488": ["Repression of WNT target genes", "TCF7L2 mutants don't bind CTBP"], "148867": ["Insulin processing", "Zinc efflux and compartmentalization by the SLC30 family"], "1489": ["IL-6-type cytokine receptor ligand interactions"], "1490": ["YAP1- and WWTR1 (TAZ)-stimulated gene expression", "RUNX3 regulates YAP1-mediated transcription"], "149018": ["Formation of the cornified envelope"], "1491": ["Degradation of cysteine and homocysteine", "Cysteine formation from homocysteine", "Metabolism of ingested SeMet, Sec, MeSec into H2Se"], "149111": ["COPII-mediated vesicle transport", "Cargo concentration in the ER"], "149233": ["Interleukin-4 and Interleukin-13 signaling", "Interleukin-23 signaling", "Interleukin-23 signaling"], "1493": ["CTLA4 inhibitory signaling", "RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)"], "149371": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Insulin processing", "VxPx cargo-targeting to cilium"], "149461": ["Tight junction interactions"], "1495": ["CDO in myogenesis", "CDO in myogenesis", "Adherens junctions interactions", "VEGFR2 mediated vascular permeability", "RHO GTPases activate IQGAPs"], "1496": ["CDO in myogenesis", "CDO in myogenesis"], "1497": ["Transport of inorganic cations/anions and amino acids/oligopeptides", "Miscellaneous transport and binding events"], "1499": ["Degradation of beta-catenin by the destruction complex", "Beta-catenin phosphorylation cascade", "TCF dependent signaling in response to WNT", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "Apoptotic cleavage of cell adhesion proteins", "CDO in myogenesis", "CDO in myogenesis", "Deactivation of the beta-catenin transactivating complex", "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "Ca2+ pathway", "Adherens junctions interactions", "Binding of TCF/LEF:CTNNB1 to target gene promoters", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "VEGFR2 mediated vascular permeability", "Misspliced GSK3beta mutants stabilize beta-catenin", "S33 mutants of beta-catenin aren't phosphorylated", "S37 mutants of beta-catenin aren't phosphorylated", "S45 mutants of beta-catenin aren't phosphorylated", "T41 mutants of beta-catenin aren't phosphorylated", "RHO GTPases activate IQGAPs", "InlA-mediated entry of Listeria monocytogenes into host cells", "RUNX3 regulates WNT signaling"], "149951": ["Neddylation"], "149954": ["Antimicrobial peptides"], "149998": ["Synthesis of PA"], "15": ["Serotonin and melatonin biosynthesis"], "150": ["Adrenoceptors", "Adrenaline signalling through Alpha-2 adrenergic receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "G alpha (i) signalling events", "G alpha (z) signalling events", "Surfactant metabolism"], "1500": ["Adherens junctions interactions", "VEGFR2 mediated vascular permeability", "InlA-mediated entry of Listeria monocytogenes into host cells"], "150094": ["Circadian Clock"], "150159": ["Stimuli-sensing channels"], "150274": ["Mitochondrial protein import", "Mitochondrial protein import", "Mitochondrial iron-sulfur cluster biogenesis"], "1503": ["Interconversion of nucleotide di- and triphosphates"], "150372": ["Neutrophil degranulation"], "150379": ["Triglyceride catabolism"], "1504": ["Activation of Matrix Metalloproteinases", "Cobalamin (Cbl, vitamin B12) transport and metabolism"], "150465": ["Carboxyterminal post-translational modifications of tubulin"], "150681": ["Olfactory Signaling Pathway"], "150684": ["Neddylation"], "150726": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "150737": ["Intraflagellar transport", "Intraflagellar transport"], "150763": ["Synthesis of PA", "Triglyceride biosynthesis"], "1508": ["Collagen degradation", "Trafficking and processing of endosomal TLR", "Assembly of collagen fibrils and other multimeric structures", "MHC class II antigen presentation", "Neutrophil degranulation"], "1509": ["Collagen degradation", "Metabolism of Angiotensinogen to Angiotensins", "MHC class II antigen presentation", "Neutrophil degranulation", "Estrogen-dependent gene expression"], "151": ["Adrenoceptors", "Adrenaline signalling through Alpha-2 adrenergic receptor", "G alpha (i) signalling events", "G alpha (z) signalling events"], "1510": ["MHC class II antigen presentation"], "151056": ["Acyl chain remodelling of PC", "Retinoid metabolism and transport"], "1511": ["Degradation of the extracellular matrix", "Activation of Matrix Metalloproteinases", "Metabolism of Angiotensinogen to Angiotensins", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Neutrophil degranulation", "Antimicrobial peptides"], "151194": ["Protein methylation"], "1512": ["MHC class II antigen presentation", "Surfactant metabolism", "Neutrophil degranulation"], "151246": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "1513": ["Collagen degradation", "Degradation of the extracellular matrix", "Activation of Matrix Metalloproteinases", "Trafficking and processing of endosomal TLR", "MHC class II antigen presentation", "RUNX1 regulates transcription of genes involved in differentiation of keratinocytes"], "151306": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (s) signalling events"], "1514": ["Endosomal/Vacuolar pathway", "Collagen degradation", "Degradation of the extracellular matrix", "Trafficking and processing of endosomal TLR", "Assembly of collagen fibrils and other multimeric structures", "MHC class II antigen presentation", "RUNX1 regulates transcription of genes involved in differentiation of keratinocytes"], "1515": ["Endosomal/Vacuolar pathway", "Degradation of the extracellular matrix", "Activation of Matrix Metalloproteinases", "Trafficking and processing of endosomal TLR", "Assembly of collagen fibrils and other multimeric structures", "MHC class II antigen presentation", "RUNX1 regulates transcription of genes involved in differentiation of keratinocytes"], "151531": ["Pyrimidine salvage", "Pyrimidine catabolism"], "151636": ["Antigen processing: Ubiquitination & Proteasome degradation"], "151648": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "151742": ["Sphingolipid de novo biosynthesis"], "151888": ["Costimulation by the CD28 family", "Costimulation by the CD28 family"], "1519": ["MHC class II antigen presentation"], "151987": ["Processing of DNA double-strand break ends"], "152": ["Adrenoceptors", "Adrenaline signalling through Alpha-2 adrenergic receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "G alpha (i) signalling events", "G alpha (z) signalling events", "Surfactant metabolism"], "1520": ["Endosomal/Vacuolar pathway", "Degradation of the extracellular matrix", "Degradation of the extracellular matrix", "Trafficking and processing of endosomal TLR", "Assembly of collagen fibrils and other multimeric structures", "MHC class II antigen presentation", "Neutrophil degranulation"], "1521": ["Platelet degranulation "], "1522": ["Metabolism of Angiotensinogen to Angiotensins", "COPII-mediated vesicle transport", "Lysosome Vesicle Biogenesis", "Cargo concentration in the ER", "Neutrophil degranulation"], "1523": ["Signaling by cytosolic FGFR1 fusion mutants", "Signaling by FGFR1 in disease", "Intra-Golgi traffic"], "152330": ["Post-translational modification: synthesis of GPI-anchored proteins"], "1524": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "1525": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall"], "152503": ["Golgi Associated Vesicle Biogenesis"], "152519": ["Miscellaneous transport and binding events"], "152559": ["Negative regulation of MAPK pathway"], "152687": ["Generic Transcription Pathway"], "1528": ["Vitamin C (ascorbate) metabolism"], "152831": ["PI3K Cascade", "PIP3 activates AKT signaling", "betaKlotho-mediated ligand binding", "Constitutive Signaling by Aberrant PI3K in Cancer", "Phospholipase C-mediated cascade; FGFR4", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "PI-3K cascade:FGFR4", "Negative regulation of FGFR4 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "152926": ["Branched-chain amino acid catabolism"], "152992": ["tRNA modification in the nucleus and cytosol"], "153": ["Adrenoceptors", "G alpha (s) signalling events"], "153090": ["Regulation of RAS by GAPs", "Signaling by RAS mutants"], "153129": ["Macroautophagy", "mTOR signalling", "mTORC1-mediated signalling", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Regulation of PTEN gene transcription"], "153201": ["Amino acid transport across the plasma membrane", "Proton-coupled neutral amino acid transporters", "Defective SLC36A2 causes iminoglycinuria (IG) and hyperglycinuria (HG)"], "153222": ["CREB3 factors activate genes"], "1535": ["ROS, RNS production in phagocytes", "Cross-presentation of particulate exogenous antigens (phagosomes)", "Detoxification of Reactive Oxygen Species", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate NADPH Oxidases", "Neutrophil degranulation"], "153579": ["Butyrophilin (BTN) family interactions"], "1536": ["ROS, RNS production in phagocytes", "Cross-presentation of particulate exogenous antigens (phagosomes)", "Detoxification of Reactive Oxygen Species", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate NADPH Oxidases", "Neutrophil degranulation"], "153642": ["Glycosphingolipid metabolism", "The activation of arylsulfatases"], "1537": ["Mitochondrial protein import", "Respiratory electron transport"], "154": ["Adrenoceptors", "G alpha (s) signalling events", "Ub-specific processing proteases", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "1540": ["NOD1/2 Signaling Pathway", "TNFR1-induced proapoptotic signaling", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "Ub-specific processing proteases", "Negative regulators of DDX58/IFIH1 signaling"], "154007": ["mRNA Splicing - Minor Pathway"], "154064": ["Post-translational modification: synthesis of GPI-anchored proteins"], "154091": ["Cellular hexose transport"], "154141": ["Acyl chain remodelling of PS", "Acyl chain remodelling of PE"], "154214": ["Antigen processing: Ubiquitination & Proteasome degradation"], "1543": ["PPARA activates gene expression", "Xenobiotics", "Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)", "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)", "Biosynthesis of protectins"], "1544": ["Methylation", "Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2", "Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)", "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)", "Aflatoxin activation and detoxification", "Biosynthesis of protectins", "Biosynthesis of maresin-like SPMs"], "1545": ["Endogenous sterols", "Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)", "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)", "Defective CYP1B1 causes Glaucoma"], "154664": ["Neutrophil degranulation"], "154796": ["Signaling by Hippo"], "1548": ["Xenobiotics", "CYP2E1 reactions"], "154807": ["Metabolism of vitamin K"], "154810": ["Signaling by Hippo"], "154881": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "1549": ["Fatty acids", "Xenobiotics", "CYP2E1 reactions"], "155": ["Adrenoceptors", "G alpha (s) signalling events"], "155030": ["Uncoating of the HIV Virion", "Budding and maturation of HIV virion", "Integration of provirus", "Early Phase of HIV Life Cycle", "Minus-strand DNA synthesis", "Plus-strand DNA synthesis", "2-LTR circle formation", "Binding and entry of HIV virion", "Membrane binding and targetting of GAG proteins", "Synthesis And Processing Of GAG, GAGPOL Polyproteins", "Assembly Of The HIV Virion", "Integration of viral DNA into host genomic DNA", "Autointegration results in viral DNA circles", "APOBEC3G mediated resistance to HIV-1 infection", "Vpr-mediated nuclear import of PICs"], "155054": ["Generic Transcription Pathway"], "155061": ["Generic Transcription Pathway"], "155066": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "1551": ["Xenobiotics"], "155184": ["Cellular hexose transport"], "1553": ["Fatty acids", "Xenobiotics", "CYP2E1 reactions", "Aflatoxin activation and detoxification"], "155348": ["Uncoating of the HIV Virion", "Budding and maturation of HIV virion", "Integration of provirus", "Early Phase of HIV Life Cycle", "Minus-strand DNA synthesis", "Plus-strand DNA synthesis", "2-LTR circle formation", "Binding and entry of HIV virion", "Assembly Of The HIV Virion", "Integration of viral DNA into host genomic DNA", "Autointegration results in viral DNA circles", "APOBEC3G mediated resistance to HIV-1 infection", "Vpr-mediated nuclear import of PICs"], "155382": ["Budding and maturation of HIV virion", "Membrane binding and targetting of GAG proteins", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "155459": ["Uncoating of the HIV Virion", "Budding and maturation of HIV virion", "Integration of provirus", "Early Phase of HIV Life Cycle", "Minus-strand DNA synthesis", "Plus-strand DNA synthesis", "2-LTR circle formation", "Binding and entry of HIV virion", "Assembly Of The HIV Virion", "Integration of viral DNA into host genomic DNA", "Autointegration results in viral DNA circles", "Vif-mediated degradation of APOBEC3G", "APOBEC3G mediated resistance to HIV-1 infection", "Vpr-mediated nuclear import of PICs"], "1555": ["Fatty acids", "Xenobiotics", "CYP2E1 reactions"], "1557": ["Xenobiotics", "CYP2E1 reactions", "Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)", "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)"], "1558": ["Xenobiotics", "CYP2E1 reactions", "Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)", "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)", "Biosynthesis of maresin-like SPMs"], "155871": ["Formation of HIV-1 elongation complex containing HIV-1 Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "Interactions of Tat with host cellular proteins"], "1559": ["Xenobiotics", "CYP2E1 reactions", "Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)", "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)", "Biosynthesis of maresin-like SPMs"], "155908": ["Uncoating of the HIV Virion", "Budding and maturation of HIV virion", "Integration of provirus", "Early Phase of HIV Life Cycle", "Minus-strand DNA synthesis", "Plus-strand DNA synthesis", "2-LTR circle formation", "Rev-mediated nuclear export of HIV RNA", "Binding and entry of HIV virion", "Assembly Of The HIV Virion", "Integration of viral DNA into host genomic DNA", "Autointegration results in viral DNA circles", "APOBEC3G mediated resistance to HIV-1 infection", "Nuclear import of Rev protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs"], "155971": ["Alpha-defensins", "Budding and maturation of HIV virion", "Synthesis and processing of ENV and VPU", "Binding and entry of HIV virion", "Assembly Of The HIV Virion", "Dectin-2 family"], "156": ["Calmodulin induced events", "G alpha (q) signalling events", "G alpha (s) signalling events", "Activation of SMO", "Activation of SMO", "Cargo recognition for clathrin-mediated endocytosis"], "156110": ["Uncoating of the HIV Virion", "Budding and maturation of HIV virion", "Late Phase of HIV Life Cycle", "Nef mediated downregulation of CD28 cell surface expression", "Nef mediated downregulation of MHC class I complex cell surface expression", "Nef and signal transduction", "Nef Mediated CD4 Down-regulation", "Binding and entry of HIV virion", "Assembly Of The HIV Virion", "Nef Mediated CD8 Down-regulation"], "1562": ["Xenobiotics"], "1565": ["Fatty acids", "Miscellaneous substrates", "Xenobiotics", "CYP2E1 reactions", "Biosynthesis of maresin-like SPMs"], "157": ["G alpha (s) signalling events", "Cargo recognition for clathrin-mediated endocytosis"], "1571": ["Xenobiotics", "CYP2E1 reactions", "Biosynthesis of maresin-like SPMs"], "1572": ["Fatty acids", "Xenobiotics", "CYP2E1 reactions"], "1573": ["Fatty acids", "Xenobiotics", "Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)"], "157506": ["The canonical retinoid cycle in rods (twilight vision)", "RA biosynthesis pathway"], "157570": ["Establishment of Sister Chromatid Cohesion"], "1576": ["Xenobiotics", "Aflatoxin activation and detoxification", "Biosynthesis of maresin-like SPMs"], "1577": ["Xenobiotics", "Aflatoxin activation and detoxification"], "157807": ["Lysosome Vesicle Biogenesis"], "157855": ["Sperm Motility And Taxes"], "157869": ["Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "1579": ["PPARA activates gene expression", "Fatty acids", "Miscellaneous substrates", "Eicosanoids", "Synthesis of Leukotrienes (LT) and Eoxins (EX)", "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)"], "158": ["Purine ribonucleoside monophosphate biosynthesis"], "1580": ["Fatty acids", "Miscellaneous substrates", "Eicosanoids", "Synthesis of Leukotrienes (LT) and Eoxins (EX)"], "158067": ["Interconversion of nucleotide di- and triphosphates"], "1581": ["Synthesis of bile acids and bile salts", "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "PPARA activates gene expression", "Endogenous sterols"], "158131": ["Olfactory Signaling Pathway"], "158135": ["Carboxyterminal post-translational modifications of tubulin"], "1582": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of bile acids and bile salts via 24-hydroxycholesterol", "Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "Nicotinamide salvaging", "Eicosanoids", "Sterols are 12-hydroxylated by CYP8B1", "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"], "1583": ["Pregnenolone biosynthesis", "Endogenous sterols", "Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)"], "158399": ["Generic Transcription Pathway"], "1584": ["Glucocorticoid biosynthesis", "Endogenous sterols", "Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4)"], "158431": ["Generic Transcription Pathway"], "1585": ["Mineralocorticoid biosynthesis", "Glucocorticoid biosynthesis", "Endogenous sterols", "Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)"], "158506": ["Antigen processing: Ubiquitination & Proteasome degradation"], "158584": ["Arachidonic acid metabolism"], "1586": ["Androgen biosynthesis", "Glucocorticoid biosynthesis", "Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)"], "158747": ["Neutrophil degranulation"], "158763": ["Rho GTPase cycle"], "1588": ["Estrogen biosynthesis", "Endogenous sterols", "Defective CYP19A1 causes Aromatase excess syndrome (AEXS)"], "158833": ["Arachidonic acid metabolism", "Wax biosynthesis"], "158835": ["Acyl chain remodeling of DAG and TAG", "The retinoid cycle in cones (daylight vision)", "Wax biosynthesis"], "1589": ["Mineralocorticoid biosynthesis", "Glucocorticoid biosynthesis", "Endogenous sterols", "Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)"], "159": ["Purine ribonucleoside monophosphate biosynthesis"], "1591": ["Vitamin D (calciferol) metabolism", "Vitamins", "Defective CYP24A1 causes Hypercalcemia, infantile (HCAI)"], "1592": ["Vitamins", "RA biosynthesis pathway"], "1593": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of bile acids and bile salts via 24-hydroxycholesterol", "Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "Endogenous sterols", "Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX)"], "1594": ["Vitamin D (calciferol) metabolism", "Vitamins", "Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A)"], "1595": ["Cholesterol biosynthesis", "Endogenous sterols", "Activation of gene expression by SREBF (SREBP)"], "159963": ["Multifunctional anion exchangers"], "16": ["Cytosolic tRNA aminoacylation"], "160": ["Nef Mediated CD4 Down-regulation", "Retrograde neurotrophin signalling", "Retrograde neurotrophin signalling", "Nef Mediated CD8 Down-regulation", "MHC class II antigen presentation", "EPH-ephrin mediated repulsion of cells", "Trafficking of GluR2-containing AMPA receptors", "Recycling pathway of L1", "Recycling pathway of L1", "WNT5A-dependent internalization of FZD4", "WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "VLDLR internalisation and degradation", "LDL clearance"], "1600": ["Reelin signalling pathway"], "1601": ["Gap junction degradation", "Formation of annular gap junctions", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "160287": ["Pyruvate metabolism"], "1603": ["Asparagine N-linked glycosylation"], "160364": ["Neutrophil degranulation"], "1604": ["Class B/2 (Secretin family receptors)", "Neutrophil degranulation", "COPI-mediated anterograde transport", "Regulation of Complement cascade"], "160428": ["Metabolism of folate and pterines"], "1605": ["Non-integrin membrane-ECM interactions", "ECM proteoglycans", "ECM proteoglycans", "Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3", "Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2", "Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1", "O-linked glycosylation", "Regulation of expression of SLITs and ROBOs"], "160518": ["RAB GEFs exchange GTP for GDP on RABs"], "1606": ["Effects of PIP2 hydrolysis"], "1607": ["Effects of PIP2 hydrolysis"], "160728": ["Nicotinamide salvaging", "Organic anion transporters"], "1608": ["Effects of PIP2 hydrolysis"], "160851": ["Effects of PIP2 hydrolysis"], "1609": ["Effects of PIP2 hydrolysis"], "161": ["Nef Mediated CD4 Down-regulation", "Retrograde neurotrophin signalling", "Retrograde neurotrophin signalling", "Nef Mediated CD8 Down-regulation", "MHC class II antigen presentation", "EPH-ephrin mediated repulsion of cells", "Trafficking of GluR2-containing AMPA receptors", "Recycling pathway of L1", "Recycling pathway of L1", "WNT5A-dependent internalization of FZD4", "WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "Neutrophil degranulation", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "VLDLR internalisation and degradation", "LDL clearance"], "1610": ["Glyoxylate metabolism and glycine degradation", "Peroxisomal protein import", "Peroxisomal protein import"], "161003": ["Stimuli-sensing channels"], "1612": ["Caspase activation via Dependence Receptors in the absence of ligand"], "161247": ["Lipid particle organization"], "1613": ["Caspase activation via Dependence Receptors in the absence of ligand"], "161357": ["Post-translational modification: synthesis of GPI-anchored proteins"], "1615": ["SeMet incorporation into proteins", "Cytosolic tRNA aminoacylation"], "1616": ["SUMOylation of transcription cofactors", "Regulation of TP53 Degradation"], "161725": ["Ovarian tumor domain proteases"], "161742": ["Regulation of RAS by GAPs", "FGFRL1 modulation of FGFR1 signaling", "Signaling by RAS mutants"], "161823": ["Abacavir metabolism", "Purine salvage"], "161882": ["RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Factors involved in megakaryocyte development and platelet production"], "162": ["Nef mediated downregulation of MHC class I complex cell surface expression", "MHC class II antigen presentation", "Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis"], "1621": ["Catecholamine biosynthesis"], "1622": ["Mitochondrial Fatty Acid Beta-Oxidation"], "162239": ["Generic Transcription Pathway"], "162417": ["Urea cycle"], "162466": ["Synthesis of PC", "Synthesis of PE"], "162514": ["TRP channels"], "162605": ["Keratinization", "Formation of the cornified envelope"], "162655": ["Generic Transcription Pathway"], "162699": ["Formation of RNA Pol II elongation complex ", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "RNA Polymerase II Transcription Elongation"], "1628": ["BMAL1:CLOCK,NPAS2 activates circadian gene expression"], "1629": ["Glyoxylate metabolism and glycine degradation", "Branched-chain amino acid catabolism"], "162963": ["Generic Transcription Pathway"], "162966": ["Generic Transcription Pathway"], "162967": ["Generic Transcription Pathway"], "162972": ["Generic Transcription Pathway"], "162998": ["Olfactory Signaling Pathway"], "163": ["Nef Mediated CD4 Down-regulation", "Retrograde neurotrophin signalling", "Retrograde neurotrophin signalling", "Nef Mediated CD8 Down-regulation", "MHC class II antigen presentation", "EPH-ephrin mediated repulsion of cells", "Trafficking of GluR2-containing AMPA receptors", "Recycling pathway of L1", "Recycling pathway of L1", "WNT5A-dependent internalization of FZD4", "WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "VLDLR internalisation and degradation", "LDL clearance"], "1630": ["Netrin-1 signaling", "Netrin-1 signaling", "DSCAM interactions", "DCC mediated attractive signaling", "DCC mediated attractive signaling", "Netrin mediated repulsion signals", "Caspase activation via Dependence Receptors in the absence of ligand", "Role of second messengers in netrin-1 signaling", "Regulation of commissural axon pathfinding by SLIT and ROBO"], "163049": ["Generic Transcription Pathway"], "163050": ["Generic Transcription Pathway"], "163051": ["Generic Transcription Pathway"], "163059": ["Generic Transcription Pathway"], "163071": ["Generic Transcription Pathway"], "163081": ["Generic Transcription Pathway"], "163087": ["Generic Transcription Pathway"], "163175": ["LGI-ADAM interactions"], "1632": ["mitochondrial fatty acid beta-oxidation of unsaturated fatty acids"], "163223": ["Generic Transcription Pathway"], "163227": ["Generic Transcription Pathway"], "163255": ["Generic Transcription Pathway"], "163259": ["RAB GEFs exchange GTP for GDP on RABs"], "1633": ["Pyrimidine salvage", "Purine salvage"], "163351": ["Interferon gamma signaling"], "1634": ["Degradation of the extracellular matrix", "A tetrasaccharide linker sequence is required for GAG synthesis", "Chondroitin sulfate biosynthesis", "Dermatan sulfate biosynthesis", "CS/DS degradation", "ECM proteoglycans", "ECM proteoglycans", "Defective B4GALT7 causes EDS, progeroid type", "Defective B3GAT3 causes JDSSDHD", "Defective CHST3 causes SEDCJD", "Defective CHST14 causes EDS, musculocontractural type", "Defective CHSY1 causes TPBS", "Defective B3GALT6 causes EDSP2 and SEMDJL1"], "163404": ["Lysosphingolipid and LPA receptors"], "163486": ["RAB GEFs exchange GTP for GDP on RABs"], "1635": ["Interconversion of nucleotide di- and triphosphates"], "1636": ["Metabolism of Angiotensinogen to Angiotensins"], "163702": ["Other interleukin signaling", "Interleukin-20 family signaling"], "163732": ["Activation of the TFAP2 (AP-2) family of transcription factors"], "1638": ["Melanin biosynthesis"], "1639": ["MHC class II antigen presentation", "Regulation of PLK1 Activity at G2/M Transition", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "XBP1(S) activates chaperone genes", "Anchoring of the basal body to the plasma membrane", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic", "AURKA Activation by TPX2"], "164": ["Nef mediated downregulation of MHC class I complex cell surface expression", "MHC class II antigen presentation", "Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis"], "1641": ["Neurofascin interactions"], "1642": ["Recognition of DNA damage by PCNA-containing replication complex", "DNA Damage Recognition in GG-NER", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Neddylation"], "1643": ["Ub-specific processing proteases", "DNA Damage Recognition in GG-NER", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "TP53 Regulates Transcription of DNA Repair Genes", "Neddylation"], "164395": ["Carboxyterminal post-translational modifications of tubulin"], "1644": ["Catecholamine biosynthesis", "Serotonin and melatonin biosynthesis"], "1645": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of bile acids and bile salts via 24-hydroxycholesterol", "Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "Retinoid metabolism and transport"], "1646": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of bile acids and bile salts via 24-hydroxycholesterol", "Synthesis of bile acids and bile salts via 27-hydroxycholesterol"], "164656": ["Collagen degradation", "Collagen degradation", "Degradation of the extracellular matrix", "Degradation of the extracellular matrix"], "164668": ["mRNA Editing: C to U Conversion", "Formation of the Editosome"], "1647": ["TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "FOXO-mediated transcription of cell cycle genes"], "1649": ["ATF4 activates genes", "ATF6 (ATF6-alpha) activates chaperone genes", "FOXO-mediated transcription of cell death genes", "FOXO-mediated transcription of cell death genes"], "1650": ["SRP-dependent cotranslational protein targeting to membrane", "Asparagine N-linked glycosylation", "Neutrophil degranulation", "Advanced glycosylation endproduct receptor signaling"], "165140": ["Eicosanoid ligand-binding receptors", "G alpha (i) signalling events"], "1653": ["tRNA processing in the nucleus"], "1654": ["Neutrophil degranulation"], "1655": ["SUMOylation of transcription cofactors", "mRNA Splicing - Major Pathway", "Estrogen-dependent gene expression"], "1656": ["mRNA decay by 5' to 3' exoribonuclease"], "165679": ["Sphingolipid de novo biosynthesis"], "165918": ["SUMOylation of DNA damage response and repair proteins", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "G2/M DNA damage checkpoint"], "166": ["Repression of WNT target genes"], "1660": ["RIP-mediated NFkB activation via ZBP1", "DEx/H-box helicases activate type I IFN and inflammatory cytokines production ", "mRNA Splicing - Major Pathway"], "166012": ["Chondroitin sulfate biosynthesis"], "1663": ["XBP1(S) activates chaperone genes"], "166379": ["BBSome-mediated cargo-targeting to cilium"], "1665": ["mRNA Splicing - Major Pathway"], "1666": ["mitochondrial fatty acid beta-oxidation of unsaturated fatty acids"], "1667": ["Defensins", "Alpha-defensins", "Neutrophil degranulation"], "166785": ["Cobalamin (Cbl, vitamin B12) transport and metabolism", "Defective MMAA causes methylmalonic aciduria type cblA", "Defective MUT causes methylmalonic aciduria mut type", "Propionyl-CoA catabolism"], "1668": ["Defensins", "Alpha-defensins"], "1669": ["Defensins", "Alpha-defensins", "Neutrophil degranulation"], "166929": ["Sphingolipid de novo biosynthesis"], "1670": ["Defensins", "Alpha-defensins"], "1671": ["Defensins", "Alpha-defensins"], "167127": ["Glucuronidation"], "1672": ["Beta defensins", "Defensins"], "167227": ["ATF4 activates genes", "mRNA decay by 5' to 3' exoribonuclease", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "KSRP (KHSRP) binds and destabilizes mRNA"], "1673": ["Beta defensins", "Defensins"], "1674": ["Striated Muscle Contraction"], "1675": ["Platelet degranulation ", "Alternative complement activation", "Neutrophil degranulation"], "1676": ["Activation of DNA fragmentation factor"], "1677": ["Activation of DNA fragmentation factor"], "1678": ["Mitochondrial protein import"], "168374": ["Generic Transcription Pathway"], "168391": ["O-linked glycosylation of mucins"], "168417": ["Generic Transcription Pathway"], "168544": ["Transcriptional regulation of white adipocyte differentiation"], "169026": ["Insulin processing", "Zinc efflux and compartmentalization by the SLC30 family"], "169044": ["Collagen biosynthesis and modifying enzymes", "Collagen chain trimerization"], "169270": ["Generic Transcription Pathway"], "169355": ["Tryptophan catabolism"], "169522": ["Voltage gated Potassium channels"], "169841": ["Generic Transcription Pathway"], "170482": ["Dectin-2 family", "Neutrophil degranulation"], "170506": ["DEx/H-box helicases activate type I IFN and inflammatory cytokines production "], "170572": ["Neurotransmitter receptors and postsynaptic signal transmission"], "170589": ["Hormone ligand-binding receptors", "G alpha (s) signalling events"], "170622": ["Neddylation"], "170685": ["Synthesis of pyrophosphates in the cytosol"], "170689": ["Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "170690": ["Degradation of the extracellular matrix", "Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "170691": ["Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "170692": ["Degradation of the extracellular matrix", "Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "170850": ["Voltage gated Potassium channels"], "170959": ["Generic Transcription Pathway"], "170960": ["Generic Transcription Pathway"], "171019": ["Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "171023": ["UCH proteinases"], "171169": ["Post-translational modification: synthesis of GPI-anchored proteins"], "171177": ["Rho GTPase cycle"], "171392": ["Generic Transcription Pathway"], "171546": ["Sphingolipid de novo biosynthesis"], "171558": ["NOTCH3 Intracellular Domain Regulates Transcription"], "171568": ["Cytosolic sensors of pathogen-associated DNA ", "RNA Polymerase III Chain Elongation", "RNA Polymerase III Transcription Termination", "RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "171586": ["Synthesis of PC"], "1716": ["Purine salvage"], "1717": ["Activation of gene expression by SREBF (SREBP)", "Cholesterol biosynthesis via desmosterol", "Cholesterol biosynthesis via lathosterol"], "1718": ["Cholesterol biosynthesis via desmosterol", "Cholesterol biosynthesis via lathosterol"], "1719": ["Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "Metabolism of folate and pterines", "Activation of E2F1 target genes at G1/S"], "1723": ["Pyrimidine biosynthesis"], "1725": ["Hypusine synthesis from eIF5A-lysine"], "1727": ["Vitamin C (ascorbate) metabolism", "Phase I - Functionalization of compounds", "Neutrophil degranulation"], "1728": ["Regulation of ornithine decarboxylase (ODC)"], "1729": ["RHO GTPases Activate Formins", "ERBB2 Regulates Cell Motility", "Neutrophil degranulation"], "1730": ["RHO GTPases Activate Formins"], "1733": ["Regulation of thyroid hormone activity"], "1734": ["Regulation of thyroid hormone activity"], "1735": ["Regulation of thyroid hormone activity"], "1736": ["Telomere Extension By Telomerase", "rRNA modification in the nucleus and cytosol"], "1737": ["Regulation of pyruvate dehydrogenase (PDH) complex", "Glyoxylate metabolism and glycine degradation", "Signaling by Retinoic Acid", "Pyruvate metabolism"], "1738": ["Regulation of pyruvate dehydrogenase (PDH) complex", "Glyoxylate metabolism and glycine degradation", "Signaling by Retinoic Acid", "Glycine degradation", "Pyruvate metabolism", "Branched-chain amino acid catabolism", "Lysine catabolism", "Citric acid cycle (TCA cycle)"], "1739": ["Trafficking of AMPA receptors", "Unblocking of NMDA receptors, glutamate binding and activation", "Unblocking of NMDA receptors, glutamate binding and activation", "Ras activation upon Ca2+ influx through NMDA receptor", "NrCAM interactions", "Activation of Ca-permeable Kainate Receptor", "RAF/MAP kinase cascade", "Synaptic adhesion-like molecules", "Negative regulation of NMDA receptor-mediated neuronal transmission", "Long-term potentiation"], "174": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "1740": ["Unblocking of NMDA receptors, glutamate binding and activation", "Unblocking of NMDA receptors, glutamate binding and activation", "Ras activation upon Ca2+ influx through NMDA receptor", "RAF/MAP kinase cascade", "Neurexins and neuroligins", "Neurexins and neuroligins", "Negative regulation of NMDA receptor-mediated neuronal transmission", "Long-term potentiation"], "1741": ["Unblocking of NMDA receptors, glutamate binding and activation", "Unblocking of NMDA receptors, glutamate binding and activation", "Ras activation upon Ca2+ influx through NMDA receptor", "NrCAM interactions", "Activation of Ca-permeable Kainate Receptor", "RAF/MAP kinase cascade", "Neurexins and neuroligins", "Neurexins and neuroligins", "Synaptic adhesion-like molecules", "Negative regulation of NMDA receptor-mediated neuronal transmission", "Long-term potentiation"], "1742": ["Trafficking of AMPA receptors", "Unblocking of NMDA receptors, glutamate binding and activation", "Unblocking of NMDA receptors, glutamate binding and activation", "Ras activation upon Ca2+ influx through NMDA receptor", "NrCAM interactions", "Activation of Ca-permeable Kainate Receptor", "RHO GTPases activate CIT", "RAF/MAP kinase cascade", "LGI-ADAM interactions", "Neurexins and neuroligins", "Neurexins and neuroligins", "Synaptic adhesion-like molecules", "Negative regulation of NMDA receptor-mediated neuronal transmission", "Long-term potentiation"], "1743": ["Glyoxylate metabolism and glycine degradation", "Lysine catabolism", "Citric acid cycle (TCA cycle)"], "1749": ["Regulation of RUNX2 expression and activity"], "175": ["Neutrophil degranulation"], "1750": ["Regulation of RUNX2 expression and activity"], "1755": ["Surfactant metabolism"], "1756": ["Non-integrin membrane-ECM interactions", "Striated Muscle Contraction"], "1757": ["Choline catabolism"], "1758": ["ECM proteoglycans", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "1759": ["Toll Like Receptor 4 (TLR4) Cascade", "Retrograde neurotrophin signalling", "Gap junction degradation", "Formation of annular gap junctions", "MHC class II antigen presentation", "EPH-ephrin mediated repulsion of cells", "Recycling pathway of L1", "Clathrin-mediated endocytosis"], "176": ["Degradation of the extracellular matrix", "Degradation of the extracellular matrix", "Keratan sulfate biosynthesis", "Keratan sulfate degradation", "ECM proteoglycans", "Defective CHST6 causes MCDC1", "Defective ST3GAL3 causes MCT12 and EIEE15", "Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)"], "1760": ["Ion homeostasis"], "1763": ["Removal of the Flap Intermediate from the C-strand", "HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Regulation of TP53 Activity through Phosphorylation", "Removal of the Flap Intermediate", "G2/M DNA damage checkpoint"], "177": ["TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "Advanced glycosylation endproduct receptor signaling", "Advanced glycosylation endproduct receptor signaling", "TRAF6 mediated NF-kB activation"], "1774": ["Neutrophil degranulation"], "1777": ["Lysosome Vesicle Biogenesis"], "1778": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Regulation of PLK1 Activity at G2/M Transition", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "RHO GTPases Activate Formins", "Neutrophil degranulation", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "AURKA Activation by TPX2"], "178": ["Neutrophil degranulation", "Glycogen breakdown (glycogenolysis)"], "1780": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase"], "1781": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Regulation of PLK1 Activity at G2/M Transition", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "AURKA Activation by TPX2"], "1783": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase"], "1785": ["Toll Like Receptor 4 (TLR4) Cascade", "Retrograde neurotrophin signalling", "Gap junction degradation", "Formation of annular gap junctions", "NOSTRIN mediated eNOS trafficking", "MHC class II antigen presentation", "Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis", "Recycling pathway of L1", "Clathrin-mediated endocytosis"], "1786": ["PRC2 methylates histones and DNA", "NoRC negatively regulates rRNA expression", "SUMOylation of DNA methylation proteins", "DNA methylation"], "1787": ["tRNA modification in the nucleus and cytosol"], "1788": ["PRC2 methylates histones and DNA", "RMTs methylate histone arginines", "SUMOylation of DNA methylation proteins", "DNA methylation"], "1789": ["PRC2 methylates histones and DNA", "NoRC negatively regulates rRNA expression", "SUMOylation of DNA methylation proteins", "DNA methylation"], "1793": ["Regulation of actin dynamics for phagocytic cup formation", "DCC mediated attractive signaling", "DCC mediated attractive signaling", "VEGFA-VEGFR2 Pathway", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "Factors involved in megakaryocyte development and platelet production"], "1794": ["Nef and signal transduction", "Neutrophil degranulation", "Factors involved in megakaryocyte development and platelet production"], "1795": ["NTRK2 activates RAC1", "NTRK2 activates RAC1", "Factors involved in megakaryocyte development and platelet production"], "1796": ["PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "RET signaling"], "1798": ["Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2"], "18": ["Degradation of GABA"], "1800": ["Synthesis of Leukotrienes (LT) and Eoxins (EX)", "Aflatoxin activation and detoxification"], "1801": ["Synthesis of diphthamide-EEF2"], "1802": ["Synthesis of diphthamide-EEF2"], "1803": ["Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)"], "1806": ["Pyrimidine catabolism"], "1807": ["Pyrimidine catabolism"], "1808": ["CRMPs in Sema3A signaling", "Recycling pathway of L1"], "1809": ["CRMPs in Sema3A signaling"], "181": ["FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes"], "1810": ["HATs acetylate histones"], "1811": ["Multifunctional anion exchangers", "Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1)"], "1812": ["Dopamine receptors", "G alpha (s) signalling events"], "1813": ["Dopamine receptors", "G alpha (i) signalling events"], "1814": ["Dopamine receptors", "G alpha (i) signalling events"], "1815": ["Dopamine receptors", "G alpha (i) signalling events"], "1816": ["Dopamine receptors", "G alpha (s) signalling events"], "182": ["Activated NOTCH1 Transmits Signal to the Nucleus", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant", "Constitutive Signaling by NOTCH1 HD Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "NOTCH2 Activation and Transmission of Signal to the Nucleus", "RUNX3 regulates NOTCH signaling", "NOTCH3 Activation and Transmission of Signal to the Nucleus", "NOTCH3 Activation and Transmission of Signal to the Nucleus", "NOTCH4 Activation and Transmission of Signal to the Nucleus"], "1820": ["TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest"], "1822": ["Regulation of PTEN gene transcription"], "1823": ["Neutrophil degranulation", "Keratinization", "Formation of the cornified envelope"], "1824": ["Keratinization", "Formation of the cornified envelope"], "1825": ["Keratinization", "Formation of the cornified envelope"], "1826": ["DSCAM interactions", "DSCAM interactions"], "1828": ["Apoptotic cleavage of cell adhesion proteins", "Neutrophil degranulation", "Keratinization", "Formation of the cornified envelope"], "1829": ["Apoptotic cleavage of cell adhesion proteins", "Keratinization", "Formation of the cornified envelope"], "183": ["PPARA activates gene expression", "Metabolism of Angiotensinogen to Angiotensins", "Metabolism of Angiotensinogen to Angiotensins", "Peptide ligand-binding receptors", "G alpha (q) signalling events", "G alpha (i) signalling events"], "1830": ["Apoptotic cleavage of cell adhesion proteins", "Keratinization", "Formation of the cornified envelope"], "1831": ["Stimuli-sensing channels"], "1832": ["Apoptotic cleavage of cell adhesion proteins", "Neutrophil degranulation", "Keratinization", "Formation of the cornified envelope"], "1834": ["ECM proteoglycans"], "1836": ["Transport and synthesis of PAPS", "Defective SLC26A2 causes chondrodysplasias", "Multifunctional anion exchangers"], "1839": ["Signaling by ERBB2", "Signaling by ERBB4", "SHC1 events in ERBB2 signaling", "SHC1 events in ERBB2 signaling", "PI3K events in ERBB4 signaling", "SHC1 events in ERBB4 signaling", "Nuclear signaling by ERBB4", "PIP3 activates AKT signaling", "Signaling by EGFR", "GRB2 events in EGFR signaling", "GAB1 signalosome", "SHC1 events in EGFR signaling", "EGFR downregulation", "GRB2 events in ERBB2 signaling", "PI3K events in ERBB2 signaling", "EGFR interacts with phospholipase C-gamma", "EGFR Transactivation by Gastrin", "EGFR Transactivation by Gastrin", "Constitutive Signaling by Aberrant PI3K in Cancer", "Uptake and function of diphtheria toxin", "Inhibition of Signaling by Overexpressed EGFR", "RAF/MAP kinase cascade", "ERBB2 Regulates Cell Motility", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "ERBB2 Activates PTK6 Signaling", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "PTK6 promotes HIF1A stabilization", "Downregulation of ERBB2 signaling"], "1840": ["Activated NOTCH1 Transmits Signal to the Nucleus", "Activated NOTCH1 Transmits Signal to the Nucleus"], "1841": ["Interconversion of nucleotide di- and triphosphates"], "1843": ["RAF-independent MAPK1/3 activation", "Negative regulation of MAPK pathway"], "1844": ["RAF-independent MAPK1/3 activation", "Negative regulation of MAPK pathway"], "1845": ["ERKs are inactivated"], "1846": ["RAF-independent MAPK1/3 activation", "ERKs are inactivated", "Negative regulation of MAPK pathway"], "1847": ["RAF-independent MAPK1/3 activation", "Negative regulation of MAPK pathway"], "1848": ["RAF-independent MAPK1/3 activation", "ERKs are inactivated", "Negative regulation of MAPK pathway"], "1849": ["RAF-independent MAPK1/3 activation", "ERKs are inactivated", "Negative regulation of MAPK pathway"], "185": ["Peptide ligand-binding receptors", "G alpha (q) signalling events", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "1850": ["RAF-independent MAPK1/3 activation", "Negative regulation of MAPK pathway"], "1852": ["RAF-independent MAPK1/3 activation", "Negative regulation of MAPK pathway"], "1854": ["Interconversion of nucleotide di- and triphosphates"], "1855": ["TCF dependent signaling in response to WNT", "WNT mediated activation of DVL", "PCP/CE pathway", "PCP/CE pathway", "Degradation of DVL", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Negative regulation of TCF-dependent signaling by DVL-interacting proteins", "RHO GTPases Activate Formins"], "1856": ["TCF dependent signaling in response to WNT", "WNT mediated activation of DVL", "Signaling by Hippo", "PCP/CE pathway", "PCP/CE pathway", "Asymmetric localization of PCP proteins", "Degradation of DVL", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "WNT5A-dependent internalization of FZD4", "Negative regulation of TCF-dependent signaling by DVL-interacting proteins", "RHO GTPases Activate Formins", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "1857": ["TCF dependent signaling in response to WNT", "WNT mediated activation of DVL", "PCP/CE pathway", "PCP/CE pathway", "Degradation of DVL", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Negative regulation of TCF-dependent signaling by DVL-interacting proteins", "RHO GTPases Activate Formins"], "1859": ["G0 and Early G1"], "186": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "1861": ["Cargo recognition for clathrin-mediated endocytosis"], "1869": ["Activation of NOXA and translocation to mitochondria", "Inhibition of replication initiation of damaged DNA by RB1/E2F1", "Transcription of E2F targets under negative control by DREAM complex", "Transcription of E2F targets under negative control by DREAM complex", "Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1", "Activation of PUMA and translocation to mitochondria", "Pre-NOTCH Transcription and Translation", "Pre-NOTCH Transcription and Translation", "Oxidative Stress Induced Senescence", "Oncogene Induced Senescence", "Activation of E2F1 target genes at G1/S", "Activation of E2F1 target genes at G1/S", "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "CDC6 association with the ORC:origin complex", "G2 Phase", "Cyclin E associated events during G1/S transition ", "Cyclin D associated events in G1", "Cyclin A:Cdk2-associated events at S phase entry", "Transcriptional Regulation by E2F6"], "187": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "1870": ["Oxidative Stress Induced Senescence", "Oncogene Induced Senescence", "CDC6 association with the ORC:origin complex", "Cyclin D associated events in G1"], "1871": ["Pre-NOTCH Transcription and Translation", "Pre-NOTCH Transcription and Translation", "Oxidative Stress Induced Senescence", "Oncogene Induced Senescence", "CDC6 association with the ORC:origin complex", "G2 Phase", "Cyclin D associated events in G1"], "1874": ["Transcription of E2F targets under negative control by DREAM complex", "Transcription of E2F targets under negative control by DREAM complex", "Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1", "G0 and Early G1", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Activation of E2F1 target genes at G1/S", "Activation of E2F1 target genes at G1/S", "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "Cyclin E associated events during G1/S transition ", "Cyclin D associated events in G1", "Cyclin A:Cdk2-associated events at S phase entry"], "1875": ["Transcription of E2F targets under negative control by DREAM complex", "Transcription of E2F targets under negative control by DREAM complex", "Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1", "G0 and Early G1", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Activation of E2F1 target genes at G1/S", "Activation of E2F1 target genes at G1/S", "Cyclin E associated events during G1/S transition ", "Cyclin D associated events in G1", "Cyclin A:Cdk2-associated events at S phase entry"], "1876": ["Activation of E2F1 target genes at G1/S", "Transcriptional Regulation by E2F6"], "1879": ["Transcriptional regulation of white adipocyte differentiation"], "1880": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (i) signalling events"], "1889": ["Peptide ligand-binding receptors"], "189": ["Glyoxylate metabolism and glycine degradation", "Peroxisomal protein import", "Peroxisomal protein import"], "1890": ["Pyrimidine salvage", "Pyrimidine catabolism"], "1891": ["Peroxisomal protein import", "Peroxisomal protein import"], "1892": ["Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "Beta oxidation of butanoyl-CoA to acetyl-CoA"], "1893": ["Platelet degranulation "], "1894": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "1896": ["TNFs bind their physiological receptors"], "19": ["PPARA activates gene expression", "Defective ABCA1 causes Tangier disease", "HDL assembly"], "190": ["Nuclear Receptor transcription pathway"], "1901": ["G alpha (i) signalling events", "Lysosphingolipid and LPA receptors", "Interleukin-4 and Interleukin-13 signaling"], "1902": ["G alpha (q) signalling events", "G alpha (i) signalling events", "Lysosphingolipid and LPA receptors"], "1903": ["G alpha (i) signalling events", "Lysosphingolipid and LPA receptors"], "1906": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "1907": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "1908": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "1909": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "191": ["Methylation", "Sulfur amino acid metabolism", "Metabolism of ingested SeMet, Sec, MeSec into H2Se", "Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD)"], "1910": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "1911": ["Oxidative Stress Induced Senescence", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of transcription cofactors", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA methylation proteins", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription", "Transcriptional Regulation by E2F6"], "1912": ["Oxidative Stress Induced Senescence", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of transcription cofactors", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA methylation proteins", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription"], "1915": ["Eukaryotic Translation Elongation", "Eukaryotic Translation Elongation", "Peptide chain elongation", "HSF1 activation", "Neutrophil degranulation", "Protein methylation"], "1917": ["Eukaryotic Translation Elongation"], "192111": ["Receptor Mediated Mitophagy"], "192134": ["O-linked glycosylation of mucins"], "192666": ["Keratinization", "Formation of the cornified envelope"], "192668": ["Trafficking of myristoylated proteins to the cilium"], "192669": ["Pre-NOTCH Transcription and Translation", "MicroRNA (miRNA) biogenesis", "Oxidative Stress Induced Senescence", "Oncogene Induced Senescence", "Ca2+ pathway", "Small interfering RNA (siRNA) biogenesis", "Post-transcriptional silencing by small RNAs", "TP53 Regulates Metabolic Genes", "MAPK6/MAPK4 signaling", "Regulation of RUNX1 Expression and Activity", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Regulation of PTEN mRNA translation", "Competing endogenous RNAs (ceRNAs) regulate PTEN translation", "Transcriptional Regulation by MECP2", "Transcriptional Regulation by MECP2", "Estrogen-dependent gene expression", "Regulation of MECP2 expression and activity"], "192670": ["Pre-NOTCH Transcription and Translation", "MicroRNA (miRNA) biogenesis", "Oxidative Stress Induced Senescence", "Oncogene Induced Senescence", "Ca2+ pathway", "Small interfering RNA (siRNA) biogenesis", "Post-transcriptional silencing by small RNAs", "TP53 Regulates Metabolic Genes", "MAPK6/MAPK4 signaling", "Regulation of RUNX1 Expression and Activity", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Regulation of PTEN mRNA translation", "Competing endogenous RNAs (ceRNAs) regulate PTEN translation", "Transcriptional Regulation by MECP2", "Transcriptional Regulation by MECP2", "Estrogen-dependent gene expression", "Regulation of MECP2 expression and activity"], "1933": ["Eukaryotic Translation Elongation"], "1936": ["Eukaryotic Translation Elongation"], "1937": ["Eukaryotic Translation Elongation"], "1938": ["Peptide chain elongation", "Peptide chain elongation", "Uptake and function of diphtheria toxin", "Synthesis of diphthamide-EEF2", "Synthesis of diphthamide-EEF2", "Neutrophil degranulation", "Protein methylation"], "1942": ["EPH-Ephrin signaling", "EPH-Ephrin signaling", "EPHA-mediated growth cone collapse", "EPHA-mediated growth cone collapse", "EPH-ephrin mediated repulsion of cells", "EPH-ephrin mediated repulsion of cells"], "1943": ["EPH-Ephrin signaling", "EPH-Ephrin signaling", "EPHA-mediated growth cone collapse", "EPHA-mediated growth cone collapse", "EPH-ephrin mediated repulsion of cells", "EPH-ephrin mediated repulsion of cells"], "1944": ["EPH-Ephrin signaling", "EPH-Ephrin signaling", "EPHA-mediated growth cone collapse", "EPHA-mediated growth cone collapse", "EPH-ephrin mediated repulsion of cells", "EPH-ephrin mediated repulsion of cells"], "1945": ["EPH-Ephrin signaling", "EPH-Ephrin signaling", "EPHA-mediated growth cone collapse", "EPHA-mediated growth cone collapse", "EPH-ephrin mediated repulsion of cells", "EPH-ephrin mediated repulsion of cells"], "1946": ["EPH-Ephrin signaling", "EPH-Ephrin signaling", "EPHA-mediated growth cone collapse", "EPHA-mediated growth cone collapse", "EPH-ephrin mediated repulsion of cells", "EPH-ephrin mediated repulsion of cells"], "1947": ["EPH-Ephrin signaling", "EPH-Ephrin signaling", "EPHB-mediated forward signaling", "EPHB-mediated forward signaling", "Ephrin signaling", "Ephrin signaling", "EPH-ephrin mediated repulsion of cells"], "1948": ["EPH-Ephrin signaling", "EPH-Ephrin signaling", "EPHB-mediated forward signaling", "EPHB-mediated forward signaling", "Ephrin signaling", "Ephrin signaling", "EPH-ephrin mediated repulsion of cells"], "1949": ["EPH-Ephrin signaling", "EPH-Ephrin signaling", "EPHB-mediated forward signaling", "EPHB-mediated forward signaling", "Ephrin signaling", "Ephrin signaling", "EPH-ephrin mediated repulsion of cells"], "1950": ["Platelet degranulation ", "Signaling by ERBB2", "Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "Signaling by ERBB4", "SHC1 events in ERBB2 signaling", "SHC1 events in ERBB2 signaling", "PLCG1 events in ERBB2 signaling", "PIP3 activates AKT signaling", "Signaling by EGFR", "Signaling by EGFR", "GRB2 events in EGFR signaling", "GAB1 signalosome", "SHC1 events in EGFR signaling", "EGFR downregulation", "GRB2 events in ERBB2 signaling", "PI3K events in ERBB2 signaling", "EGFR interacts with phospholipase C-gamma", "Constitutive Signaling by Aberrant PI3K in Cancer", "Constitutive Signaling by EGFRvIII", "Inhibition of Signaling by Overexpressed EGFR", "RAF/MAP kinase cascade", "ERBB2 Regulates Cell Motility", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "ERBB2 Activates PTK6 Signaling", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "Downregulation of ERBB2 signaling", "NOTCH3 Activation and Transmission of Signal to the Nucleus"], "1956": ["Signaling by ERBB2", "Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "Signaling by ERBB4", "SHC1 events in ERBB2 signaling", "SHC1 events in ERBB2 signaling", "PLCG1 events in ERBB2 signaling", "PIP3 activates AKT signaling", "Signaling by EGFR", "GRB2 events in EGFR signaling", "GAB1 signalosome", "SHC1 events in EGFR signaling", "EGFR downregulation", "GRB2 events in ERBB2 signaling", "PI3K events in ERBB2 signaling", "EGFR interacts with phospholipase C-gamma", "EGFR Transactivation by Gastrin", "Constitutive Signaling by Aberrant PI3K in Cancer", "Signal transduction by L1", "Constitutive Signaling by EGFRvIII", "Inhibition of Signaling by Overexpressed EGFR", "RAF/MAP kinase cascade", "ERBB2 Regulates Cell Motility", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "ERBB2 Activates PTK6 Signaling", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "PTK6 promotes HIF1A stabilization", "Downregulation of ERBB2 signaling", "TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "NOTCH3 Activation and Transmission of Signal to the Nucleus"], "1958": ["Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription", "Interferon alpha/beta signaling"], "195814": ["RA biosynthesis pathway"], "1959": ["Transcriptional regulation of white adipocyte differentiation", "Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "196": ["PPARA activates gene expression", "Phase I - Functionalization of compounds", "Endogenous sterols", "Xenobiotics", "Aryl hydrocarbon receptor signalling"], "196051": ["Role of phospholipids in phagocytosis"], "1962": ["Beta-oxidation of very long chain fatty acids", "Peroxisomal protein import", "Peroxisomal protein import"], "196335": ["Olfactory Signaling Pathway"], "196374": ["Keratinization", "Formation of the cornified envelope"], "1964": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "196483": ["Protein methylation"], "1965": ["L13a-mediated translational silencing of Ceruloplasmin expression", "PERK regulates gene expression", "ABC-family proteins mediated transport", "Translation initiation complex formation", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Recycling of eIF2:GDP"], "196500": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "196513": ["mRNA decay by 5' to 3' exoribonuclease"], "196527": ["Stimuli-sensing channels", "Neutrophil degranulation"], "196528": ["RMTs methylate histone arginines", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "1967": ["Recycling of eIF2:GDP"], "196743": ["PAOs oxidise polyamines to amines", "Interconversion of polyamines", "Peroxisomal protein import", "Peroxisomal protein import"], "1968": ["L13a-mediated translational silencing of Ceruloplasmin expression", "ABC-family proteins mediated transport", "Translation initiation complex formation", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Recycling of eIF2:GDP"], "196883": ["Glucagon signaling in metabolic regulation", "PKA activation", "PKA activation in glucagon signalling", "Adenylate cyclase activating pathway", "Adenylate cyclase inhibitory pathway", "Adenylate cyclase inhibitory pathway", "G alpha (s) signalling events", "G alpha (s) signalling events", "G alpha (i) signalling events", "G alpha (z) signalling events", "G alpha (z) signalling events", "Vasopressin regulates renal water homeostasis via Aquaporins", "Hedgehog 'off' state"], "1969": ["EPH-Ephrin signaling", "EPH-Ephrin signaling", "EPHA-mediated growth cone collapse", "EPHA-mediated growth cone collapse", "EPH-ephrin mediated repulsion of cells", "EPH-ephrin mediated repulsion of cells"], "197": ["Platelet degranulation ", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Neutrophil degranulation", "Post-translational protein phosphorylation"], "197131": ["Antigen processing: Ubiquitination & Proteasome degradation"], "197257": ["Mitochondrial protein import", "Mitochondrial protein import"], "197258": ["GDP-fucose biosynthesis"], "197259": ["TRP channels", "RIPK1-mediated regulated necrosis"], "1973": ["ISG15 antiviral mechanism", "L13a-mediated translational silencing of Ceruloplasmin expression", "Deadenylation of mRNA", "Translation initiation complex formation", "Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "197320": ["Generic Transcription Pathway"], "197322": ["Synthesis of very long-chain fatty acyl-CoAs"], "197342": ["Resolution of D-loop Structures through Holliday Junction Intermediates", "Fanconi Anemia Pathway"], "197358": ["IRF3-mediated induction of type I IFN"], "197370": ["SUMOylation of DNA damage response and repair proteins"], "1974": ["ISG15 antiviral mechanism", "L13a-mediated translational silencing of Ceruloplasmin expression", "Deadenylation of mRNA", "Translation initiation complex formation", "Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "1975": ["L13a-mediated translational silencing of Ceruloplasmin expression", "mTORC1-mediated signalling", "Deadenylation of mRNA", "Translation initiation complex formation", "Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "1977": ["ISG15 antiviral mechanism", "L13a-mediated translational silencing of Ceruloplasmin expression", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "mTORC1-mediated signalling", "Deadenylation of mRNA", "Translation initiation complex formation", "Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "1978": ["mTORC1-mediated signalling", "Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S"], "1981": ["ISG15 antiviral mechanism", "L13a-mediated translational silencing of Ceruloplasmin expression", "mTORC1-mediated signalling", "Deadenylation of mRNA", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Translation initiation complex formation", "Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "1982": ["ISG15 antiviral mechanism"], "1983": ["Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "1984": ["Hypusine synthesis from eIF5A-lysine"], "1991": ["Collagen degradation", "Degradation of the extracellular matrix", "Degradation of the extracellular matrix", "Activation of Matrix Metalloproteinases", "Neutrophil degranulation", "Antimicrobial peptides", "Regulation of Complement cascade"], "1992": ["Neutrophil degranulation"], "1993": ["mRNA Splicing - Major Pathway"], "1994": ["HuR (ELAVL1) binds and stabilizes mRNA", "mRNA Splicing - Major Pathway"], "199675": ["Neutrophil degranulation"], "199692": ["Generic Transcription Pathway"], "199699": ["Signaling by NODAL", "Regulation of signaling by NODAL"], "1997": ["RUNX1 regulates transcription of genes involved in BCR signaling", "RUNX1 regulates transcription of genes involved in interleukin signaling"], "199704": ["Generic Transcription Pathway"], "199746": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing"], "199777": ["Generic Transcription Pathway"], "1998": ["RUNX1 regulates transcription of genes involved in BCR signaling"], "199834": ["Formation of the cornified envelope"], "199857": ["Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)"], "1999": ["Pre-NOTCH Transcription and Translation"], "199990": ["Fanconi Anemia Pathway"], "2": ["Platelet degranulation ", "Intrinsic Pathway of Fibrin Clot Formation", "Degradation of the extracellular matrix", "Rho GTPase cycle", "HDL assembly"], "20": ["ABC transporters in lipid homeostasis"], "200010": ["Cellular hexose transport"], "200081": ["Other interleukin signaling"], "200132": ["Intraflagellar transport"], "200186": ["Transcriptional activation of mitochondrial biogenesis", "Circadian Clock"], "2002": ["ERK/MAPK targets"], "200315": ["mRNA Editing: C to U Conversion", "Formation of the Editosome"], "200424": ["TET1,2,3 and TDG demethylate DNA"], "200576": ["Synthesis of PIPs at the Golgi membrane", "Synthesis of PIPs at the Golgi membrane", "Synthesis of PIPs at the early endosome membrane", "Synthesis of PIPs at the early endosome membrane", "Synthesis of PIPs at the late endosome membrane", "Synthesis of PIPs at the late endosome membrane"], "2006": ["Degradation of the extracellular matrix", "Elastic fibre formation", "Molecules associated with elastic fibres", "Molecules associated with elastic fibres"], "200734": ["Regulation of RAS by GAPs", "FGFRL1 modulation of FGFR1 signaling", "Signaling by RAS mutants"], "200845": ["RUNX1 regulates estrogen receptor mediated transcription", "Neddylation", "Estrogen-dependent gene expression", "Antigen processing: Ubiquitination & Proteasome degradation"], "200879": ["Synthesis of PA"], "200894": ["ARL13B-mediated ciliary trafficking of INPP5E"], "200895": ["Metabolism of folate and pterines"], "200909": ["Neurotransmitter receptors and postsynaptic signal transmission"], "200916": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "200958": ["Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)", "Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)", "Defective GALNT12 causes colorectal cancer 1 (CRCS1)", "Dectin-2 family", "MET activates RAS signaling", "O-linked glycosylation of mucins", "Termination of O-glycan biosynthesis"], "200959": ["GABA A (rho) receptor activation"], "2010": ["Clearance of Nuclear Envelope Membranes from Chromatin", "Initiation of Nuclear Envelope Reformation", "Depolymerisation of the Nuclear Lamina"], "201164": ["Synthesis of PG", "Synthesis of PA", "PIWI-interacting RNA (piRNA) biogenesis"], "201176": ["Rho GTPase cycle"], "201254": ["Deposition of new CENPA-containing nucleosomes at the centromere", "Fanconi Anemia Pathway"], "201294": ["Neutrophil degranulation"], "201456": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "201475": ["RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "2015": ["Class B/2 (Secretin family receptors)"], "201514": ["Generic Transcription Pathway"], "201562": ["Synthesis of very long-chain fatty acyl-CoAs"], "201626": ["OAS antiviral response"], "201627": ["RAB GEFs exchange GTP for GDP on RABs"], "2017": ["RHO GTPases activate PAKs", "Clathrin-mediated endocytosis"], "2023": ["Glycolysis", "Gluconeogenesis"], "202559": ["PTK6 Regulates Proteins Involved in RNA Processing"], "2026": ["Glycolysis", "Gluconeogenesis"], "2027": ["Glycolysis", "Gluconeogenesis"], "2028": ["Metabolism of Angiotensinogen to Angiotensins"], "2029": ["MASTL Facilitates Mitotic Progression", "MASTL Facilitates Mitotic Progression"], "203": ["Interconversion of nucleotide di- and triphosphates"], "2030": ["Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"], "203068": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "Neutrophil degranulation", "AURKA Activation by TPX2"], "203190": ["LGI-ADAM interactions"], "2033": ["Regulation of gene expression by Hypoxia-inducible Factor", "RORA activates gene expression", "RORA activates gene expression", "Polo-like kinase mediated events", "Pre-NOTCH Transcription and Translation", "Pre-NOTCH Transcription and Translation", "PPARA activates gene expression", "Formation of the beta-catenin:TCF transactivating complex", "Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "NOTCH1 Intracellular Domain Regulates Transcription", "NOTCH1 Intracellular Domain Regulates Transcription", "NOTCH2 intracellular domain regulates transcription", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "HATs acetylate histones", "Attenuation phase", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation", "SUMOylation of transcription cofactors", "Circadian Clock", "Circadian Clock", "B-WICH complex positively regulates rRNA expression", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "CD209 (DC-SIGN) signaling", "Metalloprotease DUBs", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "Regulation of TP53 Activity through Acetylation", "Regulation of TP53 Activity through Methylation", "PI5P Regulates TP53 Acetylation", "Activation of the TFAP2 (AP-2) family of transcription factors", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "RUNX3 regulates NOTCH signaling", "RUNX3 regulates NOTCH signaling", "Regulation of RUNX3 expression and activity", "RUNX3 regulates p14-ARF", "NOTCH3 Intracellular Domain Regulates Transcription", "NOTCH3 Intracellular Domain Regulates Transcription", "NOTCH4 Intracellular Domain Regulates Transcription", "Estrogen-dependent gene expression", "TRAF3-dependent IRF activation pathway", "TRAF6 mediated IRF7 activation", "FOXO-mediated transcription of cell death genes", "Regulation of FOXO transcriptional activity by acetylation", "Regulation of FOXO transcriptional activity by acetylation"], "2034": ["Regulation of gene expression by Hypoxia-inducible Factor", "Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Transcriptional regulation of pluripotent stem cells", "PTK6 Expression", "Neddylation"], "2035": ["Neurexins and neuroligins"], "2036": ["Trafficking of AMPA receptors", "Neurexins and neuroligins"], "2037": ["Neurexins and neuroligins"], "203859": ["Stimuli-sensing channels"], "2039": ["Miscellaneous transport and binding events"], "204": ["Interconversion of nucleotide di- and triphosphates"], "2040": ["Stimuli-sensing channels", "Neutrophil degranulation"], "2041": ["EPH-Ephrin signaling", "EPH-Ephrin signaling", "POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation", "EPHA-mediated growth cone collapse", "EPHA-mediated growth cone collapse", "EPH-ephrin mediated repulsion of cells", "EPH-ephrin mediated repulsion of cells"], "2042": ["EPH-Ephrin signaling", "EPH-Ephrin signaling", "EPHA-mediated growth cone collapse", "EPHA-mediated growth cone collapse", "EPH-ephrin mediated repulsion of cells", "EPH-ephrin mediated repulsion of cells"], "204219": ["Sphingolipid de novo biosynthesis"], "2043": ["EPH-Ephrin signaling", "EPH-Ephrin signaling", "EPHA-mediated growth cone collapse", "EPHA-mediated growth cone collapse", "EPH-ephrin mediated repulsion of cells", "EPH-ephrin mediated repulsion of cells"], "2044": ["EPH-Ephrin signaling", "EPH-Ephrin signaling", "EPHA-mediated growth cone collapse", "EPHA-mediated growth cone collapse", "EPH-ephrin mediated repulsion of cells", "EPH-ephrin mediated repulsion of cells"], "2045": ["EPH-Ephrin signaling", "EPH-Ephrin signaling", "EPHA-mediated growth cone collapse", "EPHA-mediated growth cone collapse", "EPH-ephrin mediated repulsion of cells", "EPH-ephrin mediated repulsion of cells"], "2046": ["EPH-Ephrin signaling", "EPH-Ephrin signaling", "EPHA-mediated growth cone collapse", "EPHA-mediated growth cone collapse", "EPH-ephrin mediated repulsion of cells", "EPH-ephrin mediated repulsion of cells"], "2047": ["EPH-Ephrin signaling", "EPH-Ephrin signaling", "EPHB-mediated forward signaling", "EPHB-mediated forward signaling", "Ephrin signaling", "Ephrin signaling", "EPH-ephrin mediated repulsion of cells"], "2048": ["EPH-Ephrin signaling", "EPH-Ephrin signaling", "L1CAM interactions", "EPHB-mediated forward signaling", "EPHB-mediated forward signaling", "Ephrin signaling", "Ephrin signaling", "EPH-ephrin mediated repulsion of cells"], "204851": ["YAP1- and WWTR1 (TAZ)-stimulated gene expression", "Physiological factors", "Regulation of TP53 Activity through Phosphorylation"], "2049": ["EPH-Ephrin signaling", "EPH-Ephrin signaling", "EPHB-mediated forward signaling", "EPHB-mediated forward signaling", "Ephrin signaling", "Ephrin signaling", "EPH-ephrin mediated repulsion of cells"], "204962": ["Synthesis of PC", "Transport of bile salts and organic acids, metal ions and amine compounds"], "205": ["Interconversion of nucleotide di- and triphosphates"], "2050": ["EPH-Ephrin signaling", "EPH-Ephrin signaling", "EPHB-mediated forward signaling", "EPHB-mediated forward signaling", "Ephrin signaling", "Ephrin signaling", "EPH-ephrin mediated repulsion of cells"], "2051": ["EPH-Ephrin signaling", "EPH-Ephrin signaling", "EPHB-mediated forward signaling", "EPHB-mediated forward signaling", "Ephrin signaling", "Ephrin signaling", "EPH-ephrin mediated repulsion of cells"], "2052": ["Phase I - Functionalization of compounds"], "2053": ["Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)", "Biosynthesis of maresins", "Peroxisomal protein import", "Peroxisomal protein import"], "205564": ["SUMO is proteolytically processed"], "2056": ["Regulation of gene expression by Hypoxia-inducible Factor", "Signaling by Erythropoietin", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "Erythropoietin activates Phospholipase C gamma (PLCG)", "Erythropoietin activates STAT5", "Erythropoietin activates RAS", "Erythropoietin activates RAS"], "2057": ["Signaling by Erythropoietin", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "Erythropoietin activates Phospholipase C gamma (PLCG)", "Erythropoietin activates STAT5", "Erythropoietin activates RAS", "Erythropoietin activates RAS"], "2058": ["SeMet incorporation into proteins", "Cytosolic tRNA aminoacylation", "tRNA modification in the nucleus and cytosol"], "2060": ["EGFR downregulation", "Negative regulation of MET activity", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "InlB-mediated entry of Listeria monocytogenes into host cell"], "2063": ["Nuclear Receptor transcription pathway"], "206358": ["Amino acid transport across the plasma membrane", "Proton-coupled neutral amino acid transporters"], "2064": ["Signaling by ERBB2", "SHC1 events in ERBB2 signaling", "SHC1 events in ERBB2 signaling", "PLCG1 events in ERBB2 signaling", "PIP3 activates AKT signaling", "GRB7 events in ERBB2 signaling", "Downregulation of ERBB2:ERBB3 signaling", "GRB2 events in ERBB2 signaling", "GRB2 events in ERBB2 signaling", "PI3K events in ERBB2 signaling", "Constitutive Signaling by Aberrant PI3K in Cancer", "Sema4D induced cell migration and growth-cone collapse", "RAF/MAP kinase cascade", "ERBB2 Regulates Cell Motility", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "ERBB2 Activates PTK6 Signaling", "Downregulation of ERBB2 signaling", "TFAP2 (AP-2) family regulates transcription of growth factors and their receptors"], "2065": ["Signaling by ERBB2", "Signaling by ERBB4", "SHC1 events in ERBB2 signaling", "SHC1 events in ERBB2 signaling", "PIP3 activates AKT signaling", "GRB7 events in ERBB2 signaling", "Downregulation of ERBB2:ERBB3 signaling", "PI3K events in ERBB2 signaling", "Constitutive Signaling by Aberrant PI3K in Cancer", "RAF/MAP kinase cascade", "ERBB2 Regulates Cell Motility", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "ERBB2 Activates PTK6 Signaling", "Downregulation of ERBB2 signaling"], "2066": ["Signaling by ERBB2", "Signaling by ERBB4", "SHC1 events in ERBB2 signaling", "SHC1 events in ERBB2 signaling", "PI3K events in ERBB4 signaling", "SHC1 events in ERBB4 signaling", "Nuclear signaling by ERBB4", "Nuclear signaling by ERBB4", "Downregulation of ERBB4 signaling", "PIP3 activates AKT signaling", "GRB2 events in ERBB2 signaling", "PI3K events in ERBB2 signaling", "Constitutive Signaling by Aberrant PI3K in Cancer", "RAF/MAP kinase cascade", "ERBB2 Regulates Cell Motility", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "ERBB2 Activates PTK6 Signaling", "Downregulation of ERBB2 signaling", "Estrogen-dependent gene expression", "Long-term potentiation"], "2067": ["HDR through Single Strand Annealing (SSA)", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Fanconi Anemia Pathway"], "2068": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Tat-mediated elongation of the HIV-1 transcript", "Cytosolic iron-sulfur cluster assembly", "NoRC negatively regulates rRNA expression", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "mRNA Capping", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase I Transcription Termination", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE"], "2069": ["Signaling by ERBB2", "Signaling by ERBB4", "SHC1 events in ERBB2 signaling", "SHC1 events in ERBB2 signaling", "PI3K events in ERBB4 signaling", "SHC1 events in ERBB4 signaling", "Nuclear signaling by ERBB4", "PIP3 activates AKT signaling", "Signaling by EGFR", "GRB2 events in EGFR signaling", "GAB1 signalosome", "SHC1 events in EGFR signaling", "EGFR downregulation", "GRB2 events in ERBB2 signaling", "PI3K events in ERBB2 signaling", "EGFR interacts with phospholipase C-gamma", "Constitutive Signaling by Aberrant PI3K in Cancer", "Inhibition of Signaling by Overexpressed EGFR", "RAF/MAP kinase cascade", "ERBB2 Regulates Cell Motility", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "ERBB2 Activates PTK6 Signaling", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "Downregulation of ERBB2 signaling"], "207": ["Activation of BAD and translocation to mitochondria ", "PIP3 activates AKT signaling", "PIP3 activates AKT signaling", "Downregulation of ERBB2:ERBB3 signaling", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "mTOR signalling", "AKT phosphorylates targets in the cytosol", "AKT phosphorylates targets in the cytosol", "AKT phosphorylates targets in the nucleus", "Negative regulation of the PI3K/AKT network", "eNOS activation", "AKT-mediated inactivation of FOXO1A", "Integrin alphaIIb beta3 signaling", "Deactivation of the beta-catenin transactivating complex", "CD28 dependent PI3K/Akt signaling", "CTLA4 inhibitory signaling", "G beta:gamma signalling through PI3Kgamma", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "KSRP (KHSRP) binds and destabilizes mRNA", "VEGFR2 mediated vascular permeability", "TP53 Regulates Metabolic Genes", "Constitutive Signaling by AKT1 E17K in Cancer", "Interleukin-4 and Interleukin-13 signaling", "Regulation of TP53 Degradation", "Regulation of TP53 Activity through Acetylation", "Regulation of TP53 Activity through Association with Co-factors", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Cyclin E associated events during G1/S transition ", "Cyclin A:Cdk2-associated events at S phase entry", "PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "RAB GEFs exchange GTP for GDP on RABs", "RUNX2 regulates genes involved in cell migration", "Regulation of PTEN stability and activity", "Negative regulation of NOTCH4 signaling", "Regulation of localization of FOXO transcription factors"], "2070": ["Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"], "2071": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Tat-mediated elongation of the HIV-1 transcript", "NoRC negatively regulates rRNA expression", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "mRNA Capping", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase I Transcription Termination", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE"], "2072": ["HDR through Single Strand Annealing (SSA)", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Fanconi Anemia Pathway"], "2073": ["Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER"], "2074": ["ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "B-WICH complex positively regulates rRNA expression", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "RNA Polymerase I Transcription Initiation"], "2077": ["Oncogene Induced Senescence", "Oncogene Induced Senescence"], "208": ["Activation of BAD and translocation to mitochondria ", "PIP3 activates AKT signaling", "PIP3 activates AKT signaling", "Downregulation of ERBB2:ERBB3 signaling", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Activation of AKT2", "PDE3B signalling", "Inhibition of TSC complex formation by PKB", "AKT phosphorylates targets in the cytosol", "AKT phosphorylates targets in the cytosol", "AKT phosphorylates targets in the nucleus", "Negative regulation of the PI3K/AKT network", "AKT-mediated inactivation of FOXO1A", "Deactivation of the beta-catenin transactivating complex", "CD28 dependent PI3K/Akt signaling", "CTLA4 inhibitory signaling", "G beta:gamma signalling through PI3Kgamma", "VEGFR2 mediated vascular permeability", "TP53 Regulates Metabolic Genes", "Constitutive Signaling by AKT1 E17K in Cancer", "Regulation of TP53 Degradation", "Regulation of TP53 Activity through Acetylation", "Regulation of TP53 Activity through Association with Co-factors", "Cyclin E associated events during G1/S transition ", "Cyclin A:Cdk2-associated events at S phase entry", "RAB GEFs exchange GTP for GDP on RABs", "RUNX2 regulates genes involved in cell migration", "Regulation of PTEN stability and activity", "Regulation of localization of FOXO transcription factors"], "2081": ["IRE1alpha activates chaperones", "IRE1alpha activates chaperones"], "2091": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "2098": ["Glutathione conjugation"], "2099": ["Nuclear signaling by ERBB4", "PIP3 activates AKT signaling", "Constitutive Signaling by Aberrant PI3K in Cancer", "Nuclear Receptor transcription pathway", "SUMOylation of intracellular receptors", "Ovarian tumor domain proteases", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "RUNX1 regulates estrogen receptor mediated transcription", "ESR-mediated signaling", "RUNX1 regulates transcription of genes involved in WNT signaling", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Estrogen-dependent gene expression"], "21": ["ABC transporters in lipid homeostasis", "Defective ABCA3 causes pulmonary surfactant metabolism dysfunction type 3 (SMDP3)", "Surfactant metabolism", "Defective ABCA3 causes pulmonary surfactant metabolism dysfunction 3 (SMDP3)"], "210": ["Heme biosynthesis", "Neutrophil degranulation"], "2100": ["PIP3 activates AKT signaling", "Constitutive Signaling by Aberrant PI3K in Cancer", "Nuclear Receptor transcription pathway", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "ESR-mediated signaling"], "2101": ["PPARA activates gene expression", "Transcriptional activation of mitochondrial biogenesis", "Transcriptional activation of mitochondrial biogenesis", "Nuclear Receptor transcription pathway", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity"], "2103": ["Nuclear Receptor transcription pathway"], "2104": ["Nuclear Receptor transcription pathway"], "2107": ["Eukaryotic Translation Termination", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "2108": ["Respiratory electron transport"], "2109": ["Respiratory electron transport", "Protein methylation"], "211": ["Heme biosynthesis", "PPARA activates gene expression", "Transcriptional activation of mitochondrial biogenesis"], "2110": ["Respiratory electron transport"], "2113": ["Oncogene Induced Senescence"], "2114": ["Oncogene Induced Senescence"], "2118": ["MAPK6/MAPK4 signaling"], "212": ["Heme biosynthesis"], "2121": ["Hedgehog 'on' state", "Activation of SMO", "Activation of SMO"], "2122": ["PKMTs methylate histone lysines", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription"], "2125": ["Formation of the cornified envelope"], "213": ["Platelet degranulation ", "Recycling of bile acids and salts", "Scavenging of heme from plasma", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR)", "Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)", "Transport of organic anions", "Post-translational protein phosphorylation", "HDL remodeling"], "2131": ["HS-GAG biosynthesis", "Defective EXT2 causes exostoses 2", "Defective EXT1 causes exostoses 1, TRPS2 and CHDS"], "2132": ["HS-GAG biosynthesis", "Defective EXT2 causes exostoses 2", "Defective EXT1 causes exostoses 1, TRPS2 and CHDS"], "2134": ["XBP1(S) activates chaperone genes"], "2135": ["XBP1(S) activates chaperone genes"], "2137": ["XBP1(S) activates chaperone genes"], "2138": ["Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"], "2139": ["Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"], "214": ["L1CAM interactions"], "2140": ["Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"], "2146": ["PRC2 methylates histones and DNA", "Oxidative Stress Induced Senescence", "PKMTs methylate histone lysines", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription", "Transcriptional Regulation by E2F6"], "2147": ["Intrinsic Pathway of Fibrin Clot Formation", "Common Pathway of Fibrin Clot Formation", "Gamma-carboxylation of protein precursors", "Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "Removal of aminoterminal propeptides from gamma-carboxylated proteins", "Cell surface interactions at the vascular wall", "Peptide ligand-binding receptors", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "G alpha (q) signalling events", "Thrombin signalling through proteinase activated receptors (PARs)", "Platelet Aggregation (Plug Formation)", "Regulation of Complement cascade"], "2149": ["Common Pathway of Fibrin Clot Formation", "Peptide ligand-binding receptors", "G alpha (q) signalling events", "Thrombin signalling through proteinase activated receptors (PARs)", "Thrombin signalling through proteinase activated receptors (PARs)"], "215": ["ABC transporters in lipid homeostasis", "Linoleic acid (LA) metabolism", "alpha-linolenic acid (ALA) metabolism", "Beta-oxidation of very long chain fatty acids", "Defective ABCD1 causes adrenoleukodystrophy (ALD)"], "2150": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "2151": ["Peptide ligand-binding receptors", "G alpha (q) signalling events", "Thrombin signalling through proteinase activated receptors (PARs)", "Thrombin signalling through proteinase activated receptors (PARs)"], "2152": ["Extrinsic Pathway of Fibrin Clot Formation"], "2153": ["Platelet degranulation ", "Common Pathway of Fibrin Clot Formation", "COPII-mediated vesicle transport", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Cargo concentration in the ER", "Post-translational protein phosphorylation"], "2155": ["BMAL1:CLOCK,NPAS2 activates circadian gene expression", "Extrinsic Pathway of Fibrin Clot Formation", "Gamma-carboxylation of protein precursors", "Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "Removal of aminoterminal propeptides from gamma-carboxylated proteins"], "2157": ["Platelet degranulation ", "Intrinsic Pathway of Fibrin Clot Formation", "Common Pathway of Fibrin Clot Formation", "COPII-mediated vesicle transport", "Cargo concentration in the ER"], "2158": ["Extrinsic Pathway of Fibrin Clot Formation", "Intrinsic Pathway of Fibrin Clot Formation", "Gamma-carboxylation of protein precursors", "Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "Removal of aminoterminal propeptides from gamma-carboxylated proteins"], "2159": ["Extrinsic Pathway of Fibrin Clot Formation", "Intrinsic Pathway of Fibrin Clot Formation", "Common Pathway of Fibrin Clot Formation", "Gamma-carboxylation of protein precursors", "Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "Removal of aminoterminal propeptides from gamma-carboxylated proteins"], "216": ["RA biosynthesis pathway", "Fructose catabolism", "Ethanol oxidation"], "2160": ["Intrinsic Pathway of Fibrin Clot Formation"], "2161": ["Intrinsic Pathway of Fibrin Clot Formation"], "2162": ["Platelet degranulation ", "Common Pathway of Fibrin Clot Formation", "Interleukin-4 and Interleukin-13 signaling"], "2165": ["Common Pathway of Fibrin Clot Formation"], "2166": ["Arachidonic acid metabolism"], "2167": ["Triglyceride catabolism", "Triglyceride catabolism", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "2168": ["Triglyceride catabolism", "PPARA activates gene expression", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)"], "2169": ["Triglyceride catabolism"], "217": ["Metabolism of serotonin", "Ethanol oxidation"], "2170": ["Triglyceride catabolism"], "2171": ["Triglyceride catabolism", "Signaling by Retinoic Acid", "Neutrophil degranulation"], "2172": ["Recycling of bile acids and salts", "Triglyceride catabolism"], "2173": ["Triglyceride catabolism", "NOTCH3 Intracellular Domain Regulates Transcription"], "2175": ["Fanconi Anemia Pathway"], "2176": ["Fanconi Anemia Pathway", "TP53 Regulates Transcription of DNA Repair Genes"], "2177": ["Fanconi Anemia Pathway", "TP53 Regulates Transcription of DNA Repair Genes"], "2178": ["Fanconi Anemia Pathway"], "218": ["Phase I - Functionalization of compounds"], "2180": ["PPARA activates gene expression", "Linoleic acid (LA) metabolism", "alpha-linolenic acid (ALA) metabolism", "Synthesis of very long-chain fatty acyl-CoAs"], "2181": ["Synthesis of very long-chain fatty acyl-CoAs"], "2182": ["Synthesis of very long-chain fatty acyl-CoAs"], "2184": ["Phenylalanine and tyrosine catabolism"], "2185": ["Signal regulatory protein family interactions", "VEGFA-VEGFR2 Pathway", "Interleukin-2 signaling"], "2187": ["Fanconi Anemia Pathway"], "2188": ["Fanconi Anemia Pathway"], "2189": ["Fanconi Anemia Pathway"], "219": ["Ethanol oxidation"], "2192": ["Molecules associated with elastic fibres", "Molecules associated with elastic fibres"], "2193": ["Cytosolic tRNA aminoacylation"], "219333": ["Ub-specific processing proteases"], "2194": ["ChREBP activates metabolic gene expression", "Vitamin B5 (pantothenate) metabolism", "Activation of gene expression by SREBF (SREBP)", "Fatty acyl-CoA biosynthesis", "Fatty acyl-CoA biosynthesis"], "219402": ["Mitochondrial translation initiation"], "219417": ["Olfactory Signaling Pathway"], "219428": ["Olfactory Signaling Pathway"], "219429": ["Olfactory Signaling Pathway"], "219431": ["Olfactory Signaling Pathway"], "219432": ["Olfactory Signaling Pathway"], "219436": ["Olfactory Signaling Pathway"], "219437": ["Olfactory Signaling Pathway"], "219438": ["Olfactory Signaling Pathway"], "219447": ["Olfactory Signaling Pathway"], "219453": ["Olfactory Signaling Pathway"], "219464": ["Olfactory Signaling Pathway"], "219469": ["Olfactory Signaling Pathway"], "219473": ["Olfactory Signaling Pathway"], "219477": ["Olfactory Signaling Pathway"], "219479": ["Olfactory Signaling Pathway"], "219482": ["Olfactory Signaling Pathway"], "219484": ["Olfactory Signaling Pathway"], "219487": ["Olfactory Signaling Pathway"], "219493": ["Olfactory Signaling Pathway"], "219541": ["PPARA activates gene expression", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "219578": ["Generic Transcription Pathway"], "219595": ["Amino acid synthesis and interconversion (transamination)"], "219699": ["Netrin-1 signaling", "Netrin mediated repulsion signals", "Caspase activation via Dependence Receptors in the absence of ligand"], "219743": ["Peroxisomal protein import", "Peroxisomal protein import", "TYSND1 cleaves peroxisomal proteins", "TYSND1 cleaves peroxisomal proteins"], "219749": ["Generic Transcription Pathway"], "219770": ["Gap junction assembly"], "219855": ["Gluconeogenesis"], "219858": ["Olfactory Signaling Pathway"], "219865": ["Olfactory Signaling Pathway"], "219869": ["Olfactory Signaling Pathway"], "219870": ["Olfactory Signaling Pathway"], "219873": ["Olfactory Signaling Pathway"], "219874": ["Olfactory Signaling Pathway"], "219875": ["Olfactory Signaling Pathway"], "2199": ["Molecules associated with elastic fibres", "Molecules associated with elastic fibres"], "219927": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "219931": ["Stimuli-sensing channels"], "219952": ["Olfactory Signaling Pathway"], "219954": ["Olfactory Signaling Pathway"], "219956": ["Olfactory Signaling Pathway"], "219957": ["Olfactory Signaling Pathway"], "219958": ["Olfactory Signaling Pathway"], "219959": ["Olfactory Signaling Pathway"], "219960": ["Olfactory Signaling Pathway"], "219965": ["Olfactory Signaling Pathway"], "219968": ["Olfactory Signaling Pathway"], "219970": ["Conjugation of salicylate with glycine", "Conjugation of benzoate with glycine"], "219981": ["Olfactory Signaling Pathway"], "219982": ["Olfactory Signaling Pathway"], "219983": ["Olfactory Signaling Pathway"], "219986": ["Olfactory Signaling Pathway"], "219988": ["mRNA decay by 5' to 3' exoribonuclease", "mRNA decay by 5' to 3' exoribonuclease"], "22": ["Mitochondrial ABC transporters", "Cytosolic iron-sulfur cluster assembly"], "220": ["RA biosynthesis pathway"], "2200": ["Degradation of the extracellular matrix", "Degradation of the extracellular matrix", "Elastic fibre formation", "Molecules associated with elastic fibres", "Molecules associated with elastic fibres", "Integrin cell surface interactions", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "220074": ["Enzymatic degradation of dopamine by COMT"], "2201": ["Degradation of the extracellular matrix", "Elastic fibre formation", "Molecules associated with elastic fibres", "Molecules associated with elastic fibres"], "220134": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "220164": ["RET signaling"], "2202": ["Molecules associated with elastic fibres", "Molecules associated with elastic fibres"], "2203": ["Gluconeogenesis"], "2204": ["Neutrophil degranulation"], "220441": ["E3 ubiquitin ligases ubiquitinate target proteins"], "2205": ["Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation"], "2206": ["Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation"], "2207": ["GPVI-mediated activation cascade", "Cell surface interactions at the vascular wall", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "Dectin-2 family", "Dectin-2 family", "Neutrophil degranulation", "Platelet Adhesion to exposed collagen"], "2208": ["NOTCH2 intracellular domain regulates transcription", "Interleukin-10 signaling", "Interleukin-4 and Interleukin-13 signaling"], "2209": ["Cross-presentation of soluble exogenous antigens (endosomes)", "Cross-presentation of soluble exogenous antigens (endosomes)", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Interferon gamma signaling"], "220988": ["mRNA Splicing - Major Pathway", "Processing of Capped Intron-Containing Pre-mRNA"], "220992": ["Generic Transcription Pathway"], "221": ["Sphingolipid de novo biosynthesis", "Neutrophil degranulation"], "2210": ["Cross-presentation of soluble exogenous antigens (endosomes)", "Cross-presentation of soluble exogenous antigens (endosomes)", "Interferon gamma signaling"], "221002": ["RAF/MAP kinase cascade"], "221035": ["Olfactory Signaling Pathway"], "221037": ["Factors involved in megakaryocyte development and platelet production"], "221044": ["RUNX2 regulates osteoblast differentiation"], "221078": ["tRNA modification in the nucleus and cytosol"], "221120": ["ALKBH3 mediated reversal of alkylation damage"], "221143": ["Protein methylation"], "221154": ["Mitochondrial calcium ion transport", "Processing of SMDT1"], "2212": ["FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Neutrophil degranulation"], "221264": ["Interconversion of nucleotide di- and triphosphates"], "2213": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "221357": ["Glutathione conjugation"], "221391": ["G alpha (i) signalling events", "Opsins"], "221395": ["Surfactant metabolism"], "2214": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis"], "221400": ["PIWI-interacting RNA (piRNA) biogenesis"], "221458": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "221472": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "221496": ["Clearance of Nuclear Envelope Membranes from Chromatin", "Initiation of Nuclear Envelope Reformation", "Depolymerisation of the Nuclear Lamina"], "2215": ["Post-translational modification: synthesis of GPI-anchored proteins", "Neutrophil degranulation"], "221613": ["HDACs deacetylate histones", "HATs acetylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "UCH proteinases", "Ub-specific processing proteases", "Metalloprotease DUBs"], "221656": ["HDMs demethylate histones", "UCH proteinases"], "221687": ["Antigen processing: Ubiquitination & Proteasome degradation"], "221785": ["Generic Transcription Pathway"], "221823": ["5-Phosphoribose 1-diphosphate biosynthesis"], "221830": ["NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase I Transcription Termination"], "2219": ["Lectin pathway of complement activation", "Initial triggering of complement", "Ficolins bind to repetitive carbohydrate structures on the target cell surface", "Neutrophil degranulation"], "221914": ["A tetrasaccharide linker sequence is required for GAG synthesis", "HS-GAG biosynthesis", "HS-GAG biosynthesis", "HS-GAG degradation", "Defective B4GALT7 causes EDS, progeroid type", "Defective B3GAT3 causes JDSSDHD", "Defective EXT2 causes exostoses 2", "Defective EXT1 causes exostoses 1, TRPS2 and CHDS", "Defective B3GALT6 causes EDSP2 and SEMDJL1", "Retinoid metabolism and transport"], "221935": ["SDK interactions"], "221937": ["UCH proteinases"], "221955": ["Arachidonate production from DAG"], "221960": ["RAB GEFs exchange GTP for GDP on RABs"], "221981": ["Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "2220": ["Lectin pathway of complement activation", "Initial triggering of complement", "Ficolins bind to repetitive carbohydrate structures on the target cell surface"], "2222": ["Cholesterol biosynthesis", "PPARA activates gene expression", "Activation of gene expression by SREBF (SREBP)"], "222235": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "222236": ["Biosynthesis of A2E, implicated in retinal degradation"], "2224": ["Cholesterol biosynthesis", "Activation of gene expression by SREBF (SREBP)"], "222487": ["Neutrophil degranulation"], "222537": ["HS-GAG biosynthesis"], "222545": ["G alpha (q) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "222546": ["Regulation of gene expression in beta cells"], "222663": ["Degradation of the extracellular matrix"], "222962": ["Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"], "223": ["Carnitine synthesis"], "2230": ["Mitochondrial iron-sulfur cluster biogenesis", "Pregnenolone biosynthesis", "Endogenous sterols", "Electron transport from NADPH to Ferredoxin", "Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)"], "223082": ["Antigen processing: Ubiquitination & Proteasome degradation"], "2232": ["Pregnenolone biosynthesis", "Endogenous sterols", "Electron transport from NADPH to Ferredoxin", "Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)"], "2235": ["Heme biosynthesis"], "2237": ["POLB-Dependent Long Patch Base Excision Repair", "Early Phase of HIV Life Cycle", "Removal of the Flap Intermediate from the C-strand", "PCNA-Dependent Long Patch Base Excision Repair", "HDR through MMEJ (alt-NHEJ)", "Removal of the Flap Intermediate"], "2239": ["A tetrasaccharide linker sequence is required for GAG synthesis", "HS-GAG biosynthesis", "HS-GAG biosynthesis", "HS-GAG degradation", "Defective B4GALT7 causes EDS, progeroid type", "Defective B3GAT3 causes JDSSDHD", "Defective EXT2 causes exostoses 2", "Defective EXT1 causes exostoses 1, TRPS2 and CHDS", "Defective B3GALT6 causes EDSP2 and SEMDJL1", "Retinoid metabolism and transport"], "224": ["Sphingolipid de novo biosynthesis", "Alpha-oxidation of phytanate"], "2241": ["Signaling by SCF-KIT"], "2242": ["Signaling by SCF-KIT", "Sema3A PAK dependent Axon repulsion", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "CRMPs in Sema3A signaling"], "2243": ["Platelet degranulation ", "Common Pathway of Fibrin Clot Formation", "Integrin cell surface interactions", "Integrin alphaIIb beta3 signaling", "GRB2:SOS provides linkage to MAPK signaling for Integrins ", "p130Cas linkage to MAPK signaling for integrins", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "MAP2K and MAPK activation", "Regulation of TLR by endogenous ligand", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF", "Post-translational protein phosphorylation", "Amyloid fiber formation"], "2244": ["Platelet degranulation ", "Common Pathway of Fibrin Clot Formation", "Integrin cell surface interactions", "Integrin alphaIIb beta3 signaling", "GRB2:SOS provides linkage to MAPK signaling for Integrins ", "p130Cas linkage to MAPK signaling for integrins", "MAP2K and MAPK activation", "Regulation of TLR by endogenous ligand", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF"], "2245": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "2246": ["PI3K Cascade", "PIP3 activates AKT signaling", "Signaling by activated point mutants of FGFR1", "Signaling by activated point mutants of FGFR3", "FGFR4 ligand binding and activation", "FGFR1b ligand binding and activation", "FGFR3b ligand binding and activation", "FGFR3c ligand binding and activation", "FGFR1c ligand binding and activation", "FGFR2c ligand binding and activation", "FGFR2b ligand binding and activation", "FGFR3 mutant receptor activation", "Activated point mutants of FGFR2", "Constitutive Signaling by Aberrant PI3K in Cancer", "Phospholipase C-mediated cascade: FGFR1", "Phospholipase C-mediated cascade; FGFR2", "Phospholipase C-mediated cascade; FGFR3", "Phospholipase C-mediated cascade; FGFR4", "Downstream signaling of activated FGFR1", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "PI-3K cascade:FGFR3", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "PI-3K cascade:FGFR4", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "Signaling by FGFR2 in disease", "Signaling by FGFR1 in disease", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Signaling by FGFR2 IIIa TM", "Signaling by FGFR3 point mutants in cancer"], "2247": ["PI3K Cascade", "PIP3 activates AKT signaling", "Signaling by activated point mutants of FGFR1", "Signaling by activated point mutants of FGFR3", "FGFR4 ligand binding and activation", "FGFR1b ligand binding and activation", "FGFR3c ligand binding and activation", "FGFR1c ligand binding and activation", "FGFR2c ligand binding and activation", "FGFR2b ligand binding and activation", "FGFR3 mutant receptor activation", "Activated point mutants of FGFR2", "Constitutive Signaling by Aberrant PI3K in Cancer", "POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation", "Syndecan interactions", "Non-integrin membrane-ECM interactions", "Phospholipase C-mediated cascade: FGFR1", "Phospholipase C-mediated cascade; FGFR2", "Phospholipase C-mediated cascade; FGFR3", "Phospholipase C-mediated cascade; FGFR4", "Downstream signaling of activated FGFR1", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "PI-3K cascade:FGFR3", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "PI-3K cascade:FGFR4", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "Signaling by FGFR2 in disease", "Signaling by FGFR1 in disease", "FGFRL1 modulation of FGFR1 signaling", "RAF/MAP kinase cascade", "Interleukin-4 and Interleukin-13 signaling", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Signaling by FGFR2 IIIa TM", "Signaling by FGFR3 point mutants in cancer"], "2248": ["PI3K Cascade", "PIP3 activates AKT signaling", "FGFR1b ligand binding and activation", "FGFR2b ligand binding and activation", "Activated point mutants of FGFR2", "Constitutive Signaling by Aberrant PI3K in Cancer", "Phospholipase C-mediated cascade: FGFR1", "Phospholipase C-mediated cascade; FGFR2", "Downstream signaling of activated FGFR1", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Signaling by FGFR2 in disease", "FGFRL1 modulation of FGFR1 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "2249": ["PI3K Cascade", "PIP3 activates AKT signaling", "Signaling by activated point mutants of FGFR1", "Signaling by activated point mutants of FGFR3", "FGFR4 ligand binding and activation", "FGFR3c ligand binding and activation", "FGFR1c ligand binding and activation", "FGFR2c ligand binding and activation", "FGFR3 mutant receptor activation", "Activated point mutants of FGFR2", "Constitutive Signaling by Aberrant PI3K in Cancer", "Phospholipase C-mediated cascade: FGFR1", "Phospholipase C-mediated cascade; FGFR2", "Phospholipase C-mediated cascade; FGFR3", "Phospholipase C-mediated cascade; FGFR4", "Downstream signaling of activated FGFR1", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "PI-3K cascade:FGFR3", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "PI-3K cascade:FGFR4", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "Signaling by FGFR2 in disease", "Signaling by FGFR1 in disease", "FGFRL1 modulation of FGFR1 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Signaling by FGFR3 point mutants in cancer"], "225": ["ABC transporters in lipid homeostasis"], "2250": ["PI3K Cascade", "PIP3 activates AKT signaling", "Signaling by activated point mutants of FGFR1", "Signaling by activated point mutants of FGFR3", "FGFR3c ligand binding and activation", "FGFR1c ligand binding and activation", "FGFR2c ligand binding and activation", "FGFR3 mutant receptor activation", "Activated point mutants of FGFR2", "Constitutive Signaling by Aberrant PI3K in Cancer", "Phospholipase C-mediated cascade: FGFR1", "Phospholipase C-mediated cascade; FGFR2", "Phospholipase C-mediated cascade; FGFR3", "Downstream signaling of activated FGFR1", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "PI-3K cascade:FGFR3", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Signaling by FGFR2 in disease", "Signaling by FGFR1 in disease", "FGFRL1 modulation of FGFR1 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Signaling by FGFR3 point mutants in cancer"], "2251": ["PI3K Cascade", "PIP3 activates AKT signaling", "Signaling by activated point mutants of FGFR1", "FGFR4 ligand binding and activation", "FGFR1c ligand binding and activation", "FGFR2c ligand binding and activation", "Activated point mutants of FGFR2", "Constitutive Signaling by Aberrant PI3K in Cancer", "Phospholipase C-mediated cascade: FGFR1", "Phospholipase C-mediated cascade; FGFR2", "Phospholipase C-mediated cascade; FGFR4", "Downstream signaling of activated FGFR1", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "PI-3K cascade:FGFR4", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR4 signaling", "Signaling by FGFR2 in disease", "Signaling by FGFR1 in disease", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "2252": ["PI3K Cascade", "PIP3 activates AKT signaling", "FGFR2b ligand binding and activation", "Activated point mutants of FGFR2", "Constitutive Signaling by Aberrant PI3K in Cancer", "Phospholipase C-mediated cascade; FGFR2", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "Negative regulation of FGFR2 signaling", "Signaling by FGFR2 in disease", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "2253": ["PI3K Cascade", "PIP3 activates AKT signaling", "Signaling by activated point mutants of FGFR1", "Signaling by activated point mutants of FGFR3", "FGFR4 ligand binding and activation", "FGFR3b ligand binding and activation", "FGFR3c ligand binding and activation", "FGFR1c ligand binding and activation", "FGFR2c ligand binding and activation", "FGFR3 mutant receptor activation", "Activated point mutants of FGFR2", "Constitutive Signaling by Aberrant PI3K in Cancer", "Phospholipase C-mediated cascade: FGFR1", "Phospholipase C-mediated cascade; FGFR2", "Phospholipase C-mediated cascade; FGFR3", "Phospholipase C-mediated cascade; FGFR4", "Downstream signaling of activated FGFR1", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "PI-3K cascade:FGFR3", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "PI-3K cascade:FGFR4", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "Signaling by FGFR2 in disease", "Signaling by FGFR1 in disease", "FGFRL1 modulation of FGFR1 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Signaling by FGFR3 point mutants in cancer"], "2254": ["PI3K Cascade", "PIP3 activates AKT signaling", "Signaling by activated point mutants of FGFR1", "Signaling by activated point mutants of FGFR3", "FGFR4 ligand binding and activation", "FGFR3b ligand binding and activation", "FGFR3c ligand binding and activation", "FGFR1c ligand binding and activation", "FGFR2c ligand binding and activation", "FGFR3 mutant receptor activation", "Activated point mutants of FGFR2", "Constitutive Signaling by Aberrant PI3K in Cancer", "Phospholipase C-mediated cascade: FGFR1", "Phospholipase C-mediated cascade; FGFR2", "Phospholipase C-mediated cascade; FGFR3", "Phospholipase C-mediated cascade; FGFR4", "Downstream signaling of activated FGFR1", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "PI-3K cascade:FGFR3", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "PI-3K cascade:FGFR4", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "Signaling by FGFR2 in disease", "Signaling by FGFR1 in disease", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Signaling by FGFR3 point mutants in cancer"], "2255": ["PI3K Cascade", "PIP3 activates AKT signaling", "FGFR1b ligand binding and activation", "FGFR2b ligand binding and activation", "Activated point mutants of FGFR2", "Regulation of gene expression in early pancreatic precursor cells", "Constitutive Signaling by Aberrant PI3K in Cancer", "Phospholipase C-mediated cascade: FGFR1", "Phospholipase C-mediated cascade; FGFR2", "Downstream signaling of activated FGFR1", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Signaling by FGFR2 in disease", "FGFRL1 modulation of FGFR1 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "2256": ["Phase 0 - rapid depolarisation"], "2257": ["Phase 0 - rapid depolarisation"], "2258": ["Phase 0 - rapid depolarisation"], "2259": ["Phase 0 - rapid depolarisation"], "226": ["Platelet degranulation ", "Neutrophil degranulation", "Glycolysis", "Gluconeogenesis"], "2260": ["PI3K Cascade", "PIP3 activates AKT signaling", "Signaling by FGFR1 amplification mutants", "Signaling by activated point mutants of FGFR1", "FGFR1b ligand binding and activation", "FGFR1c ligand binding and activation", "FGFR1c and Klotho ligand binding and activation", "Constitutive Signaling by Aberrant PI3K in Cancer", "NCAM signaling for neurite out-growth", "Signal transduction by L1", "Phospholipase C-mediated cascade: FGFR1", "Downstream signaling of activated FGFR1", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "Negative regulation of FGFR1 signaling", "Signaling by FGFR1 in disease", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Signaling by plasma membrane FGFR1 fusions"], "2261": ["PI3K Cascade", "PIP3 activates AKT signaling", "Signaling by activated point mutants of FGFR3", "FGFR3b ligand binding and activation", "FGFR3c ligand binding and activation", "FGFR3 mutant receptor activation", "t(4;14) translocations of FGFR3", "Constitutive Signaling by Aberrant PI3K in Cancer", "Phospholipase C-mediated cascade; FGFR3", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "PI-3K cascade:FGFR3", "Negative regulation of FGFR3 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Signaling by FGFR3 fusions in cancer", "Signaling by FGFR3 point mutants in cancer"], "2262": ["A tetrasaccharide linker sequence is required for GAG synthesis", "HS-GAG biosynthesis", "HS-GAG biosynthesis", "HS-GAG degradation", "Defective B4GALT7 causes EDS, progeroid type", "Defective B3GAT3 causes JDSSDHD", "Defective EXT2 causes exostoses 2", "Defective EXT1 causes exostoses 1, TRPS2 and CHDS", "Defective B3GALT6 causes EDSP2 and SEMDJL1", "Release of Hh-Np from the secreting cell", "Retinoid metabolism and transport"], "2263": ["PI3K Cascade", "PIP3 activates AKT signaling", "FGFR2c ligand binding and activation", "FGFR2b ligand binding and activation", "Signaling by FGFR2 amplification mutants", "Activated point mutants of FGFR2", "Constitutive Signaling by Aberrant PI3K in Cancer", "Phospholipase C-mediated cascade; FGFR2", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "Negative regulation of FGFR2 signaling", "Signaling by FGFR2 in disease", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Signaling by FGFR2 IIIa TM", "Signaling by FGFR2 fusions"], "2264": ["PI3K Cascade", "PIP3 activates AKT signaling", "betaKlotho-mediated ligand binding", "FGFR4 mutant receptor activation", "FGFR4 ligand binding and activation", "Constitutive Signaling by Aberrant PI3K in Cancer", "Phospholipase C-mediated cascade; FGFR4", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "PI-3K cascade:FGFR4", "Negative regulation of FGFR4 signaling", "Signaling by FGFR4 in disease", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "2266": ["Platelet degranulation ", "Common Pathway of Fibrin Clot Formation", "Integrin cell surface interactions", "Integrin alphaIIb beta3 signaling", "GRB2:SOS provides linkage to MAPK signaling for Integrins ", "p130Cas linkage to MAPK signaling for integrins", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "MAP2K and MAPK activation", "Regulation of TLR by endogenous ligand", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF", "Post-translational protein phosphorylation"], "2268": ["FCGR activation", "Platelet sensitization by LDL", "Neutrophil degranulation"], "2271": ["Citric acid cycle (TCA cycle)"], "2274": ["PPARA activates gene expression"], "2277": ["Platelet degranulation ", "VEGF ligand-receptor interactions", "VEGF binds to VEGFR leading to receptor dimerization"], "22794": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "22795": ["Laminin interactions", "Laminin interactions"], "22796": ["COPI-mediated anterograde transport", "Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network"], "2280": ["Calcineurin activates NFAT", "TGF-beta receptor signaling activates SMADs", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "TGFBR2 Kinase Domain Mutants in Cancer", "TGFBR1 KD Mutants in Cancer", "TGFBR1 LBD Mutants in Cancer"], "22801": ["Integrin cell surface interactions", "Integrin cell surface interactions"], "22802": ["Stimuli-sensing channels"], "22803": ["Association of TriC/CCT with target proteins during biosynthesis", "Major pathway of rRNA processing in the nucleolus and cytosol"], "2281": ["Stimuli-sensing channels", "Ion homeostasis"], "22818": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "22820": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "22821": ["Regulation of RAS by GAPs", "Signaling by RAS mutants"], "22822": ["Interaction between PHLDA1 and AURKA"], "22823": ["PRC2 methylates histones and DNA"], "22824": ["Regulation of HSF1-mediated heat shock response"], "22826": ["mRNA Splicing - Major Pathway"], "22827": ["mRNA Splicing - Major Pathway"], "22829": ["Neurexins and neuroligins", "Neurexins and neuroligins"], "22832": ["Anchoring of the basal body to the plasma membrane"], "22835": ["Generic Transcription Pathway"], "22836": ["Retrograde transport at the Trans-Golgi-Network"], "22839": ["Neurexins and neuroligins", "Neurexins and neuroligins"], "22841": ["Vasopressin regulates renal water homeostasis via Aquaporins"], "22843": ["Negative regulation of NMDA receptor-mediated neuronal transmission"], "22845": ["Synthesis of Dolichyl-phosphate", "Defective DOLK causes DOLK-CDG (CDG-1m)"], "22848": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "22854": ["Post-translational modification: synthesis of GPI-anchored proteins"], "22856": ["Chondroitin sulfate biosynthesis", "Defective CHSY1 causes TPBS"], "22861": ["The NLRP1 inflammasome"], "22863": ["Macroautophagy"], "22865": ["Receptor-type tyrosine-protein phosphatases"], "22866": ["MAP2K and MAPK activation", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF"], "22869": ["Generic Transcription Pathway"], "22870": ["COPII-mediated vesicle transport"], "22871": ["Neurexins and neuroligins", "Neurexins and neuroligins"], "22872": ["COPII-mediated vesicle transport", "MHC class II antigen presentation", "XBP1(S) activates chaperone genes", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "22873": ["Hedgehog 'on' state"], "22874": ["Synthesis of PIPs at the plasma membrane"], "22875": ["Neutrophil degranulation"], "22876": ["Synthesis of PIPs at the early endosome membrane"], "22878": ["RAB GEFs exchange GTP for GDP on RABs"], "22879": ["RAB GEFs exchange GTP for GDP on RABs"], "2288": ["HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Attenuation phase", "ESR-mediated signaling", "Estrogen-dependent gene expression"], "22880": ["Fatty acyl-CoA biosynthesis"], "22885": ["DCC mediated attractive signaling"], "22888": ["Antigen processing: Ubiquitination & Proteasome degradation"], "2289": ["HSP90 chaperone cycle for steroid hormone receptors (SHR)", "ESR-mediated signaling", "MECP2 regulates neuronal receptors and channels"], "22894": ["ATF4 activates genes", "mRNA decay by 3' to 5' exoribonuclease", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "KSRP (KHSRP) binds and destabilizes mRNA", "Major pathway of rRNA processing in the nucleolus and cytosol"], "22897": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "22898": ["RAB GEFs exchange GTP for GDP on RABs"], "22899": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "229": ["Hereditary fructose intolerance", "Glycolysis", "Gluconeogenesis", "Fructose catabolism"], "2290": ["Regulation of MECP2 expression and activity", "FOXO-mediated transcription of cell cycle genes"], "22900": ["Formation of apoptosome", "Regulation of the apoptosome activity"], "22901": ["Glycosphingolipid metabolism", "The activation of arylsulfatases"], "22905": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "22906": ["Signaling by BRAF and RAF fusions"], "22908": ["Synthesis of PIPs at the ER membrane", "Synthesis of PIPs at the Golgi membrane"], "22909": ["Fanconi Anemia Pathway"], "22914": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "DAP12 interactions", "DAP12 signaling", "DAP12 signaling"], "22915": ["Platelet degranulation "], "22916": ["Cleavage of Growing Transcript in the Termination Region ", "SLBP independent Processing of Histone Pre-mRNAs", "Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Abortive elongation of HIV-1 transcript in the absence of Tat", "snRNP Assembly", "RNA Polymerase II Pre-transcription Events", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "mRNA 3'-end processing", "Processing of Capped Intron-Containing Pre-mRNA", "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "Processing of Intronless Pre-mRNAs", "Signaling by FGFR2 IIIa TM", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "22917": ["Interaction With The Zona Pellucida"], "22918": ["Neutrophil degranulation"], "22919": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "RHO GTPases Activate Formins", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "AURKA Activation by TPX2"], "22920": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "MHC class II antigen presentation", "Intraflagellar transport", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins", "Kinesins"], "22921": ["Protein repair"], "22925": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PS", "Acyl chain remodelling of PE", "Acyl chain remodelling of PI", "Acyl chain remodelling of PG", "Synthesis of PA"], "22926": ["ATF4 activates genes", "ATF6 (ATF6-alpha) activates chaperones", "ATF6 (ATF6-alpha) activates chaperone genes"], "22927": ["Platelet degranulation "], "22928": ["Selenocysteine synthesis"], "22930": ["COPI-independent Golgi-to-ER retrograde traffic", "RAB GEFs exchange GTP for GDP on RABs"], "22931": ["Neutrophil degranulation", "COPI-independent Golgi-to-ER retrograde traffic", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "22934": ["RPIA deficiency: failed conversion of R5P to RU5P", "RPIA deficiency: failed conversion of RU5P to R5P", "Pentose phosphate pathway"], "22936": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes"], "22937": ["Regulation of cholesterol biosynthesis by SREBP (SREBF)", "Regulation of cholesterol biosynthesis by SREBP (SREBF)"], "22938": ["Pre-NOTCH Transcription and Translation", "Pre-NOTCH Transcription and Translation", "Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "NOTCH1 Intracellular Domain Regulates Transcription", "NOTCH1 Intracellular Domain Regulates Transcription", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "Notch-HLH transcription pathway", "mRNA Splicing - Major Pathway", "RUNX3 regulates NOTCH signaling", "RUNX3 regulates NOTCH signaling", "NOTCH3 Intracellular Domain Regulates Transcription", "NOTCH3 Intracellular Domain Regulates Transcription", "NOTCH4 Intracellular Domain Regulates Transcription"], "22941": ["Neurexins and neuroligins", "Neurexins and neuroligins"], "22943": ["TCF dependent signaling in response to WNT", "Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling"], "22944": ["Protein methylation"], "22948": ["Prefoldin mediated transfer of substrate to CCT/TriC", "Formation of tubulin folding intermediates by CCT/TriC", "Folding of actin by CCT/TriC", "Association of TriC/CCT with target proteins during biosynthesis", "Association of TriC/CCT with target proteins during biosynthesis", "BBSome-mediated cargo-targeting to cilium", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "22949": ["Synthesis of Leukotrienes (LT) and Eoxins (EX)", "Synthesis of Lipoxins (LX)"], "22953": ["Elevation of cytosolic Ca2+ levels", "Platelet homeostasis"], "22954": ["Regulation of innate immune responses to cytosolic DNA", "Antigen processing: Ubiquitination & Proteasome degradation"], "22955": ["Oxidative Stress Induced Senescence", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of transcription cofactors", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA methylation proteins", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription"], "22974": ["Regulation of TP53 Activity through Phosphorylation", "AURKA Activation by TPX2"], "22976": ["Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Nonhomologous End-Joining (NHEJ)"], "22977": ["Aflatoxin activation and detoxification"], "22978": ["Abacavir metabolism", "Purine catabolism"], "22981": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "22984": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "22985": ["Apoptotic cleavage of cellular proteins"], "22987": ["Toxicity of botulinum toxin type D (BoNT/D)", "Toxicity of botulinum toxin type A (BoNT/A)", "Toxicity of botulinum toxin type F (BoNT/F)"], "22992": ["HDMs demethylate histones"], "22994": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "22995": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "22999": ["Serotonin Neurotransmitter Release Cycle", "Norepinephrine Neurotransmitter Release Cycle", "Glutamate Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle", "Acetylcholine Neurotransmitter Release Cycle", "GABA synthesis, release, reuptake and degradation"], "23": ["ABC-family proteins mediated transport"], "230": ["Neutrophil degranulation", "Glycolysis", "Gluconeogenesis"], "23002": ["PCP/CE pathway", "RHO GTPases Activate Formins"], "23007": ["Synthesis of IP3 and IP4 in the cytosol"], "23011": ["RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "23014": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "23016": ["ATF4 activates genes", "mRNA decay by 3' to 5' exoribonuclease", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "KSRP (KHSRP) binds and destabilizes mRNA", "Major pathway of rRNA processing in the nucleolus and cytosol"], "23019": ["Deadenylation of mRNA", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "23020": ["mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "23028": ["HDACs deacetylate histones", "HDMs demethylate histones", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Regulation of PTEN gene transcription", "Estrogen-dependent gene expression", "Factors involved in megakaryocyte development and platelet production"], "23030": ["HDMs demethylate histones", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Estrogen-dependent gene expression"], "23032": ["Ub-specific processing proteases", "Regulation of expression of SLITs and ROBOs"], "23035": ["Negative regulation of the PI3K/AKT network"], "23038": ["Neddylation"], "23043": ["Oxidative Stress Induced Senescence"], "23046": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "23047": ["Separation of Sister Chromatids", "Establishment of Sister Chromatid Cohesion", "Cohesin Loading onto Chromatin", "Resolution of Sister Chromatid Cohesion"], "23048": ["Clathrin-mediated endocytosis"], "23049": ["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "2305": ["Polo-like kinase mediated events", "Cyclin A/B1/B2 associated events during G2/M transition"], "23052": ["Platelet degranulation "], "23053": ["Regulation of expression of SLITs and ROBOs"], "23054": ["RORA activates gene expression", "BMAL1:CLOCK,NPAS2 activates circadian gene expression", "PPARA activates gene expression", "PPARA activates gene expression", "Transcriptional activation of mitochondrial biogenesis", "Activation of gene expression by SREBF (SREBP)", "Transcriptional regulation of white adipocyte differentiation", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)", "Circadian Clock", "Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "23057": ["Nicotinate metabolism"], "23059": ["Intraflagellar transport", "Intraflagellar transport"], "23062": ["TBC/RABGAPs", "Amyloid fiber formation"], "23063": ["Separation of Sister Chromatids", "Establishment of Sister Chromatid Cohesion", "Cohesin Loading onto Chromatin", "Resolution of Sister Chromatid Cohesion"], "23067": ["PKMTs methylate histone lysines", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"], "23071": ["Neutrophil degranulation"], "23072": ["Degradation of DVL"], "2308": ["AKT phosphorylates targets in the nucleus", "Regulation of gene expression in beta cells", "AKT-mediated inactivation of FOXO1A", "Constitutive Signaling by AKT1 E17K in Cancer", "MAPK6/MAPK4 signaling", "Interleukin-4 and Interleukin-13 signaling", "Regulation of localization of FOXO transcription factors", "FOXO-mediated transcription of cell death genes", "FOXO-mediated transcription of cell death genes", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "Regulation of FOXO transcriptional activity by acetylation", "Regulation of FOXO transcriptional activity by acetylation", "FOXO-mediated transcription of cell cycle genes", "FOXO-mediated transcription of cell cycle genes"], "23081": ["HDMs demethylate histones", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3"], "23082": ["Transcriptional activation of mitochondrial biogenesis"], "23087": ["Interferon gamma signaling"], "2309": ["Signaling by NODAL", "AKT phosphorylates targets in the nucleus", "Constitutive Signaling by AKT1 E17K in Cancer", "MAPK6/MAPK4 signaling", "Interleukin-4 and Interleukin-13 signaling", "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "RUNX3 regulates BCL2L11 (BIM) transcription", "Regulation of localization of FOXO transcription factors", "FOXO-mediated transcription of cell death genes", "FOXO-mediated transcription of cell death genes", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "Regulation of FOXO transcriptional activity by acetylation", "FOXO-mediated transcription of cell cycle genes", "FOXO-mediated transcription of cell cycle genes"], "23092": ["Rho GTPase cycle"], "23093": ["Carboxyterminal post-translational modifications of tubulin"], "23095": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "23097": ["PPARA activates gene expression", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "23098": ["MyD88-independent TLR4 cascade ", "Toll Like Receptor 3 (TLR3) Cascade", "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon", "IKK complex recruitment mediated by RIP1", "TRAF6-mediated induction of TAK1 complex within TLR4 complex"], "231": ["Pregnenolone biosynthesis", "Fructose biosynthesis"], "23107": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "23108": ["Rap1 signalling"], "23112": ["Pre-NOTCH Transcription and Translation", "Oxidative Stress Induced Senescence", "Oncogene Induced Senescence", "Ca2+ pathway", "Post-transcriptional silencing by small RNAs", "TP53 Regulates Metabolic Genes", "MAPK6/MAPK4 signaling", "Regulation of RUNX1 Expression and Activity", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Regulation of PTEN mRNA translation", "Competing endogenous RNAs (ceRNAs) regulate PTEN translation", "Transcriptional Regulation by MECP2", "Transcriptional Regulation by MECP2", "Estrogen-dependent gene expression", "Regulation of MECP2 expression and activity"], "23113": ["Neddylation"], "23114": ["Interaction between L1 and Ankyrins", "Neurofascin interactions", "Neurofascin interactions", "Neutrophil degranulation"], "23118": ["Nuclear signaling by ERBB4", "Nuclear signaling by ERBB4", "NOD1/2 Signaling Pathway", "Downstream TCR signaling", "FCERI mediated NF-kB activation", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "activated TAK1 mediates p38 MAPK activation", "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "TNFR1-induced NFkappaB signaling pathway", "CLEC7A (Dectin-1) signaling", "TICAM1,TRAF6-dependent induction of TAK1 complex", "Interleukin-1 signaling", "IRAK2 mediated activation of TAK1 complex", "TRAF6-mediated induction of TAK1 complex within TLR4 complex", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"], "2312": ["Formation of the cornified envelope"], "23120": ["Ion transport by P-type ATPases"], "23122": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Role of ABL in ROBO-SLIT signaling", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "23127": ["Collagen biosynthesis and modifying enzymes"], "23129": ["Other semaphorin interactions", "NOTCH3 Intracellular Domain Regulates Transcription"], "23133": ["Condensation of Prophase Chromosomes", "HDMs demethylate histones"], "23135": ["Oxidative Stress Induced Senescence", "HDMs demethylate histones"], "23136": ["Neurexins and neuroligins"], "23137": ["SUMOylation of DNA damage response and repair proteins"], "23141": ["Initiation of Nuclear Envelope Reformation"], "23142": ["Neddylation"], "23145": ["Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "23149": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "2316": ["Platelet degranulation ", "GP1b-IX-V activation signalling", "Cell-extracellular matrix interactions", "RHO GTPases activate PAKs", "OAS antiviral response"], "23160": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "23163": ["TBC/RABGAPs", "MET receptor recycling", "Amyloid fiber formation"], "23164": ["Signaling by BRAF and RAF fusions"], "23165": ["ISG15 antiviral mechanism", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "tRNA processing in the nucleus"], "23166": ["Scavenging by Class H Receptors"], "23168": ["Formation of RNA Pol II elongation complex ", "RNA Polymerase II Pre-transcription Events", "RNA Polymerase II Transcription Elongation", "E3 ubiquitin ligases ubiquitinate target proteins"], "23169": ["Formation of the active cofactor, UDP-glucuronate", "Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD)", "Transport of nucleotide sugars"], "2317": ["ISG15 antiviral mechanism"], "23170": ["Carboxyterminal post-translational modifications of tubulin"], "23171": ["Synthesis of PA"], "23172": ["Metalloprotease DUBs"], "23173": ["Inactivation, recovery and regulation of the phototransduction cascade"], "23175": ["Synthesis of PC", "Synthesis of PE", "Depolymerisation of the Nuclear Lamina", "Triglyceride biosynthesis"], "23179": ["PPARA activates gene expression"], "2318": ["Cell-extracellular matrix interactions"], "23186": ["HDACs deacetylate histones", "Regulation of PTEN gene transcription", "Factors involved in megakaryocyte development and platelet production"], "23189": ["Estrogen-dependent gene expression"], "2319": ["Synaptic adhesion-like molecules"], "23191": ["Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs", "Neutrophil degranulation"], "23192": ["Macroautophagy"], "23193": ["N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "Calnexin/calreticulin cycle"], "23194": ["FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "23197": ["Neutrophil degranulation"], "23198": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "23200": ["Neutrophil degranulation", "Ion transport by P-type ATPases"], "23203": ["Mitochondrial protein import", "Processing of SMDT1"], "23205": ["Synthesis of very long-chain fatty acyl-CoAs"], "23208": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "2321": ["Neurophilin interactions with VEGF and VEGFR", "VEGF binds to VEGFR leading to receptor dimerization"], "23210": ["HDMs demethylate histones"], "23216": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Translocation of SLC2A4 (GLUT4) to the plasma membrane"], "23218": ["Neutrophil degranulation"], "2322": ["PI3K Cascade", "Other interleukin signaling", "RAF/MAP kinase cascade"], "23220": ["IRF3 mediated activation of type 1 IFN", "Activated NOTCH1 Transmits Signal to the Nucleus", "Activated NOTCH1 Transmits Signal to the Nucleus", "Regulation of innate immune responses to cytosolic DNA", "IRF3-mediated induction of type I IFN"], "23221": ["Rho GTPase cycle"], "23224": ["Meiotic synapsis"], "23225": ["ISG15 antiviral mechanism", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "tRNA processing in the nucleus"], "23229": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events", "GABA A receptor activation", "GABA receptor activation"], "2323": ["PI3K Cascade", "Other interleukin signaling", "RAF/MAP kinase cascade"], "23236": ["PLC beta mediated events", "PLC beta mediated events", "Synthesis of IP3 and IP4 in the cytosol", "Acetylcholine regulates insulin secretion", "Acetylcholine regulates insulin secretion", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (q) signalling events", "G beta:gamma signalling through PLC beta", "Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "Presynaptic function of Kainate receptors"], "23239": ["Negative regulation of the PI3K/AKT network"], "2324": ["VEGF binds to VEGFR leading to receptor dimerization", "NOTCH4 Intracellular Domain Regulates Transcription"], "23243": ["COPII-mediated vesicle transport"], "23244": ["Separation of Sister Chromatids", "Establishment of Sister Chromatid Cohesion", "Cohesin Loading onto Chromatin", "Resolution of Sister Chromatid Cohesion"], "23246": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "23248": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes"], "23250": ["Neutrophil degranulation", "Ion transport by P-type ATPases"], "23252": ["Ovarian tumor domain proteases", "Regulation of PTEN stability and activity"], "23254": ["Formation of the cornified envelope"], "23256": ["COPII-mediated vesicle transport"], "23258": ["RAB GEFs exchange GTP for GDP on RABs"], "23259": ["Synthesis of PA"], "2326": ["FMO oxidises nucleophiles"], "23262": ["Synthesis of pyrophosphates in the cytosol"], "23263": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "23265": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Insulin processing", "VxPx cargo-targeting to cilium"], "23269": ["Transcriptional Regulation by E2F6"], "2327": ["FMO oxidises nucleophiles"], "23275": ["O-glycosylation of TSR domain-containing proteins"], "23279": ["ISG15 antiviral mechanism", "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "RHO GTPases Activate Formins", "tRNA processing in the nucleus", "Mitotic Prometaphase"], "2328": ["FMO oxidises nucleophiles", "Defective FMO3 causes Trimethylaminuria (TMAU)"], "23283": ["Cleavage of Growing Transcript in the Termination Region ", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "23286": ["Signaling by Hippo", "NOTCH3 Intracellular Domain Regulates Transcription"], "23287": ["Carboxyterminal post-translational modifications of tubulin"], "23288": ["Activation of SMO"], "23291": ["Activation of NF-kappaB in B cells", "Downstream TCR signaling", "Regulation of PLK1 Activity at G2/M Transition", "FCERI mediated NF-kB activation", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "NIK-->noncanonical NF-kB signaling", "MAP3K8 (TPL2)-dependent MAPK1/3 activation", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "23293": ["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "23295": ["Antigen processing: Ubiquitination & Proteasome degradation"], "23299": ["COPI-independent Golgi-to-ER retrograde traffic"], "23303": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "23304": ["Antigen processing: Ubiquitination & Proteasome degradation"], "23305": ["Synthesis of very long-chain fatty acyl-CoAs"], "23308": ["Costimulation by the CD28 family"], "23309": ["Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)", "NoRC negatively regulates rRNA expression", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"], "2331": ["Keratan sulfate biosynthesis", "Keratan sulfate degradation", "ECM proteoglycans", "Defective CHST6 causes MCDC1", "Defective ST3GAL3 causes MCT12 and EIEE15", "Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)"], "23310": ["Condensation of Prophase Chromosomes"], "23314": ["SUMOylation of chromatin organization proteins", "RUNX2 regulates osteoblast differentiation"], "23315": ["Sodium/Proton exchangers"], "23317": ["Neutrophil degranulation"], "23318": ["Deadenylation of mRNA"], "23321": ["Interferon gamma signaling"], "23322": ["Hedgehog 'off' state", "Anchoring of the basal body to the plasma membrane"], "23324": ["Lysosomal oligosaccharide catabolism"], "23326": ["HATs acetylate histones", "Ub-specific processing proteases"], "23327": ["Budding and maturation of HIV virion", "Downregulation of TGF-beta receptor signaling", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "Stimuli-sensing channels", "Antigen processing: Ubiquitination & Proteasome degradation"], "23332": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Role of ABL in ROBO-SLIT signaling", "Anchoring of the basal body to the plasma membrane", "RHO GTPases Activate Formins", "Mitotic Prometaphase", "AURKA Activation by TPX2"], "23338": ["HATs acetylate histones"], "23344": ["Glycosphingolipid metabolism"], "23345": ["Meiotic synapsis"], "23348": ["Factors involved in megakaryocyte development and platelet production"], "2335": ["Platelet degranulation ", "Degradation of the extracellular matrix", "Degradation of the extracellular matrix", "Extracellular matrix organization", "Fibronectin matrix formation", "Cell surface interactions at the vascular wall", "Molecules associated with elastic fibres", "Integrin cell surface interactions", "Syndecan interactions", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "Integrin alphaIIb beta3 signaling", "GRB2:SOS provides linkage to MAPK signaling for Integrins ", "p130Cas linkage to MAPK signaling for integrins", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "MAP2K and MAPK activation", "Interleukin-4 and Interleukin-13 signaling", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF", "MET activates PTK2 signaling", "Post-translational protein phosphorylation"], "23350": ["mRNA Splicing - Major Pathway"], "23352": ["Neutrophil degranulation", "Antigen processing: Ubiquitination & Proteasome degradation"], "23353": ["Meiotic synapsis"], "23354": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "23358": ["Ub-specific processing proteases"], "23363": ["Neddylation"], "23365": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events", "Sema4D induced cell migration and growth-cone collapse"], "23368": ["Activation of PUMA and translocation to mitochondria", "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "TP53 Regulates Transcription of Death Receptors and Ligands", "Regulation of TP53 Activity through Association with Co-factors"], "23369": ["Neddylation"], "23370": ["NRAGE signals death through JNK", "Rho GTPase cycle", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "G alpha (12/13) signalling events"], "23373": ["Transcriptional activation of mitochondrial biogenesis", "Circadian Clock", "Circadian Clock"], "23376": ["Antigen processing: Ubiquitination & Proteasome degradation"], "23378": ["SIRT1 negatively regulates rRNA expression"], "23379": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes"], "23380": ["Rho GTPase cycle", "Inactivation of CDC42 and RAC1", "RHO GTPases Activate Formins"], "23381": ["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "23382": ["Bicarbonate transporters"], "23383": ["Cohesin Loading onto Chromatin"], "23385": ["Nuclear signaling by ERBB4", "Degradation of the extracellular matrix", "Regulated proteolysis of p75NTR", "NRIF signals cell death from the nucleus", "Activated NOTCH1 Transmits Signal to the Nucleus", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "NOTCH2 Activation and Transmission of Signal to the Nucleus", "EPH-ephrin mediated repulsion of cells", "Neutrophil degranulation", "NOTCH3 Activation and Transmission of Signal to the Nucleus", "NOTCH4 Activation and Transmission of Signal to the Nucleus", "Noncanonical activation of NOTCH3", "Amyloid fiber formation"], "23389": ["PPARA activates gene expression", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "2339": ["Apoptotic cleavage of cellular proteins", "Inactivation, recovery and regulation of the phototransduction cascade"], "23395": ["Mitochondrial tRNA aminoacylation"], "23396": ["Synthesis of PIPs at the plasma membrane", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Clathrin-mediated endocytosis"], "23397": ["Condensation of Prometaphase Chromosomes", "Condensation of Prometaphase Chromosomes"], "23398": ["mRNA Splicing - Major Pathway"], "23399": ["Depolymerisation of the Nuclear Lamina"], "23400": ["Ion transport by P-type ATPases"], "23401": ["Beta-catenin phosphorylation cascade", "Disassembly of the destruction complex and recruitment of AXIN to the membrane"], "23404": ["ATF4 activates genes", "mRNA decay by 3' to 5' exoribonuclease", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "KSRP (KHSRP) binds and destabilizes mRNA", "Major pathway of rRNA processing in the nucleolus and cytosol"], "23405": ["MicroRNA (miRNA) biogenesis", "Small interfering RNA (siRNA) biogenesis"], "23406": ["Neutrophil degranulation"], "23408": ["Transcriptional activation of mitochondrial biogenesis"], "23409": ["Transcriptional activation of mitochondrial biogenesis"], "23410": ["Transcriptional activation of mitochondrial biogenesis", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "Regulation of FOXO transcriptional activity by acetylation"], "23411": ["Regulation of HSF1-mediated heat shock response", "Circadian Clock", "SIRT1 negatively regulates rRNA expression", "SIRT1 negatively regulates rRNA expression", "Regulation of FOXO transcriptional activity by acetylation", "Regulation of FOXO transcriptional activity by acetylation"], "23412": ["Neutrophil degranulation", "Neddylation"], "23414": ["Factors involved in megakaryocyte development and platelet production"], "23415": ["Voltage gated Potassium channels"], "23416": ["Voltage gated Potassium channels"], "23417": ["Beta-oxidation of very long chain fatty acids", "Peroxisomal protein import", "Peroxisomal protein import"], "2342": ["Inactivation, recovery and regulation of the phototransduction cascade"], "23421": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "NRIF signals cell death from the nucleus", "NRIF signals cell death from the nucleus", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Deposition of new CENPA-containing nucleosomes at the centromere", "Mitotic Prometaphase"], "23423": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "23426": ["Trafficking of GluR2-containing AMPA receptors"], "23428": ["Basigin interactions", "Amino acid transport across the plasma membrane"], "23429": ["RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Transcriptional Regulation by E2F6"], "23431": ["Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis"], "23432": ["Hedgehog 'off' state", "Hedgehog 'on' state"], "23433": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Rho GTPase cycle", "RHO GTPases regulate CFTR trafficking"], "23438": ["Mitochondrial tRNA aminoacylation"], "23439": ["SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription"], "23443": ["Defective SLC35A3 causes arthrogryposis, mental retardation, and seizures (AMRS)", "Transport of nucleotide sugars"], "23446": ["Synthesis of PC", "Transport of bile salts and organic acids, metal ions and amine compounds", "Choline catabolism"], "23450": ["mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "23451": ["B-WICH complex positively regulates rRNA expression", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "23456": ["Mitochondrial ABC transporters"], "23457": ["ABC-family proteins mediated transport"], "2346": ["Amino acid synthesis and interconversion (transamination)"], "23460": ["ABC transporters in lipid homeostasis", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes"], "23461": ["ABC transporters in lipid homeostasis"], "23462": ["NOTCH1 Intracellular Domain Regulates Transcription", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "RUNX2 regulates osteoblast differentiation", "NOTCH3 Intracellular Domain Regulates Transcription", "NOTCH4 Intracellular Domain Regulates Transcription"], "23463": ["Gamma carboxylation, hypusine formation and arylsulfatase activation"], "23464": ["Threonine catabolism"], "23466": ["Oxidative Stress Induced Senescence", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription"], "23468": ["SUMOylation of chromatin organization proteins", "Transcriptional Regulation by E2F6", "Factors involved in megakaryocyte development and platelet production"], "23471": ["SRP-dependent cotranslational protein targeting to membrane"], "23473": ["Degradation of the extracellular matrix"], "23474": ["Sulfide oxidation to sulfate"], "23475": ["Nicotinate metabolism"], "23478": ["SRP-dependent cotranslational protein targeting to membrane", "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)", "Synthesis, secretion, and deacylation of Ghrelin"], "23479": ["Mitochondrial iron-sulfur cluster biogenesis"], "2348": ["COPII-mediated vesicle transport", "Cargo concentration in the ER", "COPI-mediated anterograde transport"], "23480": ["ER-Phagosome pathway", "SRP-dependent cotranslational protein targeting to membrane", "XBP1(S) activates chaperone genes"], "23481": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "23491": ["Phase I - Functionalization of compounds", "LDL clearance"], "23493": ["NOTCH1 Intracellular Domain Regulates Transcription", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "RUNX2 regulates osteoblast differentiation", "NOTCH3 Intracellular Domain Regulates Transcription", "NOTCH4 Intracellular Domain Regulates Transcription"], "23495": ["TNFs bind their physiological receptors"], "23498": ["Tryptophan catabolism"], "2350": ["Post-translational modification: synthesis of GPI-anchored proteins", "Metabolism of folate and pterines"], "23507": ["Miscellaneous transport and binding events"], "23509": ["Pre-NOTCH Processing in the Endoplasmic Reticulum"], "23511": ["ISG15 antiviral mechanism", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "tRNA processing in the nucleus"], "23512": ["PRC2 methylates histones and DNA", "Oxidative Stress Induced Senescence", "PKMTs methylate histone lysines", "SUMOylation of chromatin organization proteins", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription", "Transcriptional Regulation by E2F6"], "23513": ["Asymmetric localization of PCP proteins"], "23514": ["Resolution of D-loop Structures through Holliday Junction Intermediates"], "23516": ["Zinc influx into cells by the SLC39 gene family"], "23517": ["Major pathway of rRNA processing in the nucleolus and cytosol", "mRNA Splicing - Major Pathway"], "2352": ["Neutrophil degranulation"], "23521": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "23522": ["HATs acetylate histones"], "23523": ["Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "23524": ["mRNA Splicing - Major Pathway"], "23526": ["Rho GTPase cycle", "Neutrophil degranulation"], "23529": ["IL-6-type cytokine receptor ligand interactions"], "2353": ["Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "FCERI mediated MAPK activation", "Activation of the AP-1 family of transcription factors", "Interleukin-4 and Interleukin-13 signaling", "TP53 Regulates Transcription of DNA Repair Genes", "Estrogen-dependent gene expression"], "23530": ["Citric acid cycle (TCA cycle)"], "23533": ["GPVI-mediated activation cascade", "Synthesis of PIPs at the plasma membrane", "G beta:gamma signalling through PI3Kgamma", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)"], "23536": ["tRNA modification in the nucleus and cytosol"], "23538": ["Olfactory Signaling Pathway"], "23539": ["Basigin interactions", "Proton-coupled monocarboxylate transport", "Pyruvate metabolism"], "2354": ["Estrogen-dependent gene expression"], "23543": ["FGFR2 alternative splicing"], "23545": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "23547": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "23555": ["Amyloid fiber formation"], "23556": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "23557": ["Golgi Associated Vesicle Biogenesis"], "2356": ["Metabolism of folate and pterines"], "23562": ["Tight junction interactions"], "23563": ["Keratan sulfate biosynthesis"], "23564": ["eNOS activation"], "23566": ["G alpha (q) signalling events", "G alpha (i) signalling events", "Lysosphingolipid and LPA receptors"], "23568": ["Regulation of insulin secretion"], "23569": ["Chromatin modifying enzymes"], "2357": ["G alpha (i) signalling events", "Formyl peptide receptors bind formyl peptides and many other ligands", "Interleukin-10 signaling", "Neutrophil degranulation"], "23576": ["eNOS activation"], "2358": ["G alpha (q) signalling events", "G alpha (i) signalling events", "Formyl peptide receptors bind formyl peptides and many other ligands", "Neutrophil degranulation"], "23581": ["Formation of the cornified envelope"], "23583": ["Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "Cleavage of the damaged pyrimidine ", "Displacement of DNA glycosylase by APEX1"], "23586": ["ISG15 antiviral mechanism", "DDX58/IFIH1-mediated induction of interferon-alpha/beta", "Ub-specific processing proteases", "Ovarian tumor domain proteases", "OAS antiviral response", "TRAF3-dependent IRF activation pathway", "TRAF6 mediated IRF7 activation", "TRAF6 mediated NF-kB activation", "TRAF6 mediated NF-kB activation", "NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10", "Negative regulators of DDX58/IFIH1 signaling", "Negative regulators of DDX58/IFIH1 signaling"], "23587": ["HATs acetylate histones"], "2359": ["G alpha (i) signalling events", "Formyl peptide receptors bind formyl peptides and many other ligands"], "23590": ["Ubiquinol biosynthesis"], "23592": ["Clearance of Nuclear Envelope Membranes from Chromatin", "Initiation of Nuclear Envelope Reformation", "Depolymerisation of the Nuclear Lamina"], "23593": ["Neutrophil degranulation"], "23594": ["E2F-enabled inhibition of pre-replication complex formation", "Activation of ATR in response to replication stress", "Assembly of the ORC complex at the origin of replication", "CDC6 association with the ORC:origin complex", "CDT1 association with the CDC6:ORC:origin complex", "Assembly of the pre-replicative complex", "Orc1 removal from chromatin", "Activation of the pre-replicative complex"], "23595": ["E2F-enabled inhibition of pre-replication complex formation", "Activation of ATR in response to replication stress", "Assembly of the ORC complex at the origin of replication", "CDC6 association with the ORC:origin complex", "CDT1 association with the CDC6:ORC:origin complex", "Assembly of the pre-replicative complex", "Orc1 removal from chromatin", "Activation of the pre-replicative complex"], "23596": ["G alpha (i) signalling events", "Opsins"], "23597": ["Mitochondrial Fatty Acid Beta-Oxidation"], "23600": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of bile acids and bile salts via 24-hydroxycholesterol", "Beta-oxidation of pristanoyl-CoA", "Peroxisomal protein import", "Peroxisomal protein import"], "23601": ["DAP12 interactions", "Neutrophil degranulation"], "23604": ["Caspase activation via Dependence Receptors in the absence of ligand"], "23607": ["Nephrin family interactions"], "23608": ["AKT phosphorylates targets in the cytosol", "Regulation of PTEN stability and activity", "Antigen processing: Ubiquitination & Proteasome degradation"], "23619": ["Generic Transcription Pathway"], "23620": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "23621": ["Amyloid fiber formation"], "23626": ["Meiotic recombination"], "23627": ["Post-translational modification: synthesis of GPI-anchored proteins"], "23630": ["Phase 3 - rapid repolarisation", "Phase 2 - plateau phase"], "23632": ["Reversible hydration of carbon dioxide"], "23636": ["ISG15 antiviral mechanism", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "tRNA processing in the nucleus"], "23637": ["TBC/RABGAPs"], "23643": ["ER-Phagosome pathway", "Caspase activation via Death Receptors in the presence of ligand", "Toll Like Receptor 4 (TLR4) Cascade", "MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "MyD88-independent TLR4 cascade ", "TRIF-mediated programmed cell death", "MyD88 deficiency (TLR2/4)", "IRAK4 deficiency (TLR2/4)", "Regulation of TLR by endogenous ligand", "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon", "IKK complex recruitment mediated by RIP1", "TRAF6-mediated induction of TAK1 complex within TLR4 complex", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"], "23644": ["mRNA decay by 5' to 3' exoribonuclease"], "23645": ["Downregulation of TGF-beta receptor signaling"], "23646": ["Synthesis of PG", "Role of phospholipids in phagocytosis"], "23647": ["Retrograde transport at the Trans-Golgi-Network"], "23649": ["Inhibition of replication initiation of damaged DNA by RB1/E2F1", "Polymerase switching on the C-strand of the telomere", "Telomere C-strand synthesis initiation", "DNA replication initiation", "Activation of the pre-replicative complex", "Polymerase switching", "Removal of the Flap Intermediate", "Processive synthesis on the lagging strand"], "23650": ["Interferon gamma signaling"], "23657": ["Basigin interactions", "Amino acid transport across the plasma membrane"], "23658": ["mRNA decay by 5' to 3' exoribonuclease", "mRNA decay by 5' to 3' exoribonuclease", "mRNA Splicing - Major Pathway"], "23659": ["Hydrolysis of LPC"], "23660": ["Generic Transcription Pathway"], "23678": ["Stimuli-sensing channels"], "23682": ["RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "23683": ["Sphingolipid de novo biosynthesis"], "23704": ["Phase 3 - rapid repolarisation", "Phase 2 - plateau phase"], "23705": ["Adherens junctions interactions", "Nectin/Necl trans heterodimerization"], "23708": ["Eukaryotic Translation Termination", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "23710": ["Macroautophagy"], "23729": ["Pentose phosphate pathway"], "23743": ["Sulfur amino acid metabolism"], "23759": ["Basigin interactions"], "23760": ["PI and PC transport between ER and Golgi membranes"], "23761": ["Synthesis of PE"], "23764": ["Factors involved in megakaryocyte development and platelet production", "Factors involved in megakaryocyte development and platelet production"], "23765": ["Interleukin-17 signaling"], "23767": ["Signaling by ROBO receptors", "Downstream signaling of activated FGFR1"], "23768": ["Downstream signaling of activated FGFR1"], "23769": ["Downstream signaling of activated FGFR1"], "23770": ["Ub-specific processing proteases"], "23774": ["HATs acetylate histones", "Regulation of TP53 Activity through Acetylation"], "23779": ["Rho GTPase cycle"], "239": ["Synthesis of Hepoxilins (HX) and Trioxilins (TrX)", "Synthesis of Lipoxins (LX)", "Synthesis of 12-eicosatetraenoic acid derivatives", "Biosynthesis of DHA-derived SPMs", "Biosynthesis of DPAn-6 SPMs", "Biosynthesis of DPAn-3-derived maresins"], "2395": ["Mitochondrial protein import", "Mitochondrial protein import", "Mitochondrial iron-sulfur cluster biogenesis"], "24": ["Retinoid cycle disease events", "The canonical retinoid cycle in rods (twilight vision)", "The canonical retinoid cycle in rods (twilight vision)", "ABC-family proteins mediated transport"], "240": ["Synthesis of 5-eicosatetraenoic acids", "Synthesis of Leukotrienes (LT) and Eoxins (EX)", "Synthesis of Lipoxins (LX)", "Interleukin-4 and Interleukin-13 signaling", "Neutrophil degranulation", "Interleukin-18 signaling", "Biosynthesis of D-series resolvins", "Biosynthesis of maresins", "Biosynthesis of E-series 18(S)-resolvins", "Biosynthesis of aspirin-triggered D-series resolvins", "Biosynthesis of E-series 18(R)-resolvins", "Biosynthesis of DPAn-3-derived protectins and resolvins", "Biosynthesis of DPAn-3-derived maresins", "Biosynthesis of DPAn-3-derived 13-series resolvins", "Biosynthesis of electrophilic \u03c9-3 PUFA oxo-derivatives"], "241": ["Synthesis of 5-eicosatetraenoic acids", "Synthesis of Leukotrienes (LT) and Eoxins (EX)", "Synthesis of Lipoxins (LX)"], "24137": ["MHC class II antigen presentation", "Recycling pathway of L1", "Recycling pathway of L1", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "24140": ["tRNA modification in the nucleus and cytosol"], "24144": ["mRNA Splicing - Major Pathway"], "24145": ["Electric Transmission Across Gap Junctions", "The NLRP3 inflammasome"], "24146": ["Tight junction interactions"], "24148": ["mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "242": ["Synthesis of 12-eicosatetraenoic acid derivatives"], "24255210": ["Toxicity of tetanus toxin (TeNT)"], "2444": ["Neutrophil degranulation", "Regulation of PTEN stability and activity"], "245908": ["Beta defensins", "Defensins"], "245909": ["Beta defensins", "Defensins"], "245910": ["Beta defensins", "Defensins"], "245911": ["Beta defensins", "Defensins"], "245913": ["Beta defensins", "Defensins"], "245915": ["Beta defensins", "Defensins"], "245927": ["Beta defensins", "Defensins"], "245928": ["Beta defensins", "Defensins"], "245929": ["Beta defensins", "Defensins"], "245930": ["Beta defensins", "Defensins"], "245932": ["Beta defensins", "Defensins"], "245934": ["Beta defensins", "Defensins"], "245936": ["Beta defensins", "Defensins"], "245937": ["Beta defensins", "Defensins"], "245938": ["Beta defensins", "Defensins"], "245939": ["Beta defensins", "Defensins"], "245940": ["Beta defensins", "Defensins"], "245972": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "245973": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "246": ["Synthesis of Leukotrienes (LT) and Eoxins (EX)", "Synthesis of 12-eicosatetraenoic acid derivatives", "Synthesis of 15-eicosatetraenoic acid derivatives", "Interleukin-4 and Interleukin-13 signaling", "Biosynthesis of DHA-derived SPMs", "Biosynthesis of protectins", "Biosynthesis of E-series 18(S)-resolvins", "Biosynthesis of E-series 18(R)-resolvins", "Biosynthesis of DPAn-6 SPMs", "Biosynthesis of DPAn-3-derived protectins and resolvins"], "246175": ["Deadenylation of mRNA", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "246181": ["Aflatoxin activation and detoxification"], "246184": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6", "Antigen processing: Ubiquitination & Proteasome degradation"], "246213": ["Organic anion transporters", "Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25)"], "246330": ["Interleukin-1 signaling", "IRAK1 recruits IKK complex", "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation"], "246778": ["Interleukin-27 signaling", "Interleukin-27 signaling"], "247": ["Synthesis of 15-eicosatetraenoic acid derivatives"], "2475": ["PIP3 activates AKT signaling", "Macroautophagy", "mTOR signalling", "mTORC1-mediated signalling", "HSF1-dependent transactivation", "Energy dependent regulation of mTOR by LKB1-AMPK", "CD28 dependent PI3K/Akt signaling", "VEGFR2 mediated vascular permeability", "TP53 Regulates Metabolic Genes", "Constitutive Signaling by AKT1 E17K in Cancer", "Regulation of TP53 Degradation", "Regulation of PTEN gene transcription"], "248": ["Synthesis of PA", "Post-translational modification: synthesis of GPI-anchored proteins", "Digestion"], "2488": ["Glycoprotein hormones", "Hormone ligand-binding receptors", "G alpha (s) signalling events"], "249": ["Post-translational modification: synthesis of GPI-anchored proteins"], "2491": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Deposition of new CENPA-containing nucleosomes at the centromere", "Mitotic Prometaphase"], "2492": ["Hormone ligand-binding receptors", "G alpha (s) signalling events"], "2494": ["Regulation of gene expression in early pancreatic precursor cells", "Nuclear Receptor transcription pathway", "SUMOylation of intracellular receptors", "Estrogen-dependent gene expression"], "2495": ["Scavenging by Class A Receptors", "Golgi Associated Vesicle Biogenesis", "Neutrophil degranulation", "Iron uptake and transport"], "25": ["Regulation of actin dynamics for phagocytic cup formation", "CDO in myogenesis", "CDO in myogenesis", "Role of ABL in ROBO-SLIT signaling", "Role of ABL in ROBO-SLIT signaling", "RHO GTPases Activate WASPs and WAVEs", "HDR through Single Strand Annealing (SSA)", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Cyclin D associated events in G1", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "RUNX2 regulates osteoblast differentiation", "Factors involved in megakaryocyte development and platelet production"], "250": ["Intra-Golgi traffic"], "251": ["Post-translational modification: synthesis of GPI-anchored proteins"], "2512": ["Scavenging by Class A Receptors", "Golgi Associated Vesicle Biogenesis", "Neutrophil degranulation", "Iron uptake and transport"], "2515": ["Interaction With The Zona Pellucida"], "2516": ["Nuclear Receptor transcription pathway", "SUMOylation of intracellular receptors", "Transcriptional regulation of pluripotent stem cells"], "2517": ["Neutrophil degranulation", "Reactions specific to the complex N-glycan synthesis pathway"], "2519": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Neutrophil degranulation", "Post-translational protein phosphorylation"], "2520": ["G alpha (q) signalling events", "Gastrin-CREB signalling pathway via PKC and MAPK"], "2521": ["mRNA Splicing - Major Pathway"], "2525": ["Reactions specific to the complex N-glycan synthesis pathway"], "252969": ["Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "Cleavage of the damaged pyrimidine ", "APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway"], "2530": ["Reactions specific to the complex N-glycan synthesis pathway"], "253017": ["Synthesis of very long-chain fatty acyl-CoAs"], "2531": ["Sphingolipid de novo biosynthesis"], "2532": ["Peptide ligand-binding receptors"], "253260": ["PIP3 activates AKT signaling", "CD28 dependent PI3K/Akt signaling", "VEGFR2 mediated vascular permeability", "Constitutive Signaling by AKT1 E17K in Cancer", "Regulation of TP53 Degradation"], "2533": ["Generation of second messenger molecules", "Generation of second messenger molecules", "Signal regulatory protein family interactions"], "2534": ["GPVI-mediated activation cascade", "Signaling by ERBB2", "PIP3 activates AKT signaling", "Signaling by SCF-KIT", "Signaling by SCF-KIT", "Regulation of KIT signaling", "Nef and signal transduction", "Cell surface interactions at the vascular wall", "FCGR activation", "PECAM1 interactions", "Constitutive Signaling by Aberrant PI3K in Cancer", "DAP12 signaling", "DAP12 signaling", "EPH-Ephrin signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Nephrin family interactions", "Nephrin family interactions", "NCAM signaling for neurite out-growth", "NCAM signaling for neurite out-growth", "CD28 co-stimulation", "CD28 dependent PI3K/Akt signaling", "CD28 dependent Vav1 pathway", "CTLA4 inhibitory signaling", "EPHB-mediated forward signaling", "EPHB-mediated forward signaling", "EPHA-mediated growth cone collapse", "EPHA-mediated growth cone collapse", "Ephrin signaling", "Ephrin signaling", "EPH-ephrin mediated repulsion of cells", "Sema3A PAK dependent Axon repulsion", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "CRMPs in Sema3A signaling", "CRMPs in Sema3A signaling", "DCC mediated attractive signaling", "DCC mediated attractive signaling", "VEGFA-VEGFR2 Pathway", "Dectin-2 family", "CD209 (DC-SIGN) signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Platelet Adhesion to exposed collagen", "Reelin signalling pathway", "Activated NTRK2 signals through FYN", "NTRK2 activates RAC1", "NTRK2 activates RAC1", "Regulation of signaling by CBL", "Regulation of signaling by CBL", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "253430": ["Synthesis of IPs in the nucleus"], "2535": ["TCF dependent signaling in response to WNT", "Class B/2 (Secretin family receptors)", "Ca2+ pathway", "Ca2+ pathway", "Asymmetric localization of PCP proteins", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "WNT5A-dependent internalization of FZD2, FZD5 and ROR2"], "253558": ["Acyl chain remodeling of CL", "Synthesis of PA"], "253559": ["Adherens junctions interactions"], "253639": ["Generic Transcription Pathway"], "2537": ["Interferon alpha/beta signaling"], "253782": ["Sphingolipid de novo biosynthesis"], "2538": ["Glycogen storage disease type Ia (G6PC)", "Gluconeogenesis", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes"], "253827": ["Protein repair"], "2539": ["TP53 Regulates Metabolic Genes", "Pentose phosphate pathway"], "253970": ["Surfactant metabolism", "Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5)", "Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)"], "254013": ["Protein methylation"], "254173": ["Carboxyterminal post-translational modifications of tubulin"], "2542": ["Glycogen storage disease type Ib (SLC37A4)", "Gluconeogenesis"], "254263": ["COPII-mediated vesicle transport", "Cargo concentration in the ER"], "254428": ["Metal ion SLC transporters"], "254531": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PS", "Acyl chain remodelling of PE", "Acyl chain remodelling of PG", "Synthesis of PA"], "2547": ["2-LTR circle formation", "Cytosolic sensors of pathogen-associated DNA ", "IRF3-mediated induction of type I IFN", "Nonhomologous End-Joining (NHEJ)", "Neutrophil degranulation"], "254783": ["Olfactory Signaling Pathway"], "254786": ["Olfactory Signaling Pathway"], "2548": ["Glycogen storage disease type II (GAA)", "Neutrophil degranulation", "Glycogen breakdown (glycogenolysis)"], "254879": ["Olfactory Signaling Pathway"], "2549": ["PI3K Cascade", "Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "PIP3 activates AKT signaling", "GAB1 signalosome", "PI3K events in ERBB2 signaling", "Constitutive Signaling by Aberrant PI3K in Cancer", "Constitutive Signaling by EGFRvIII", "PI-3K cascade:FGFR1", "PI-3K cascade:FGFR2", "PI-3K cascade:FGFR3", "PI-3K cascade:FGFR4", "Signaling by FGFR2 in disease", "Signaling by FGFR4 in disease", "Signaling by FGFR1 in disease", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "MET activates PI3K/AKT signaling", "Signaling by FGFR3 fusions in cancer", "Signaling by FGFR3 point mutants in cancer", "RET signaling", "MET activates PTPN11", "MET activates RAP1 and RAC1", "MET receptor recycling", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "Activated NTRK2 signals through PI3K"], "254910": ["Formation of the cornified envelope"], "254950": ["Keratinization"], "254973": ["Olfactory Signaling Pathway"], "2550": ["Activation of G protein gated Potassium channels", "G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)", "GABA B receptor activation", "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "255043": ["Acyl chain remodelling of PC"], "2551": ["Transcriptional activation of mitochondrial biogenesis"], "255189": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PS", "Acyl chain remodelling of PE", "Acyl chain remodelling of PI", "Acyl chain remodelling of PG", "Hydrolysis of LPC"], "255231": ["TRP channels"], "2553": ["Transcriptional activation of mitochondrial biogenesis"], "255324": ["PIP3 activates AKT signaling", "Signaling by EGFR", "GRB2 events in EGFR signaling", "GAB1 signalosome", "SHC1 events in EGFR signaling", "EGFR downregulation", "EGFR interacts with phospholipase C-gamma", "Constitutive Signaling by Aberrant PI3K in Cancer", "Inhibition of Signaling by Overexpressed EGFR", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "2554": ["GABA A receptor activation", "GABA receptor activation"], "255403": ["Generic Transcription Pathway"], "255488": ["Antigen processing: Ubiquitination & Proteasome degradation"], "2555": ["GABA A receptor activation", "GABA receptor activation"], "2556": ["GABA A receptor activation", "GABA receptor activation"], "255626": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "HATs acetylate histones", "HATs acetylate histones", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Ub-specific processing proteases", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "E3 ubiquitin ligases ubiquitinate target proteins", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "255631": ["Collagen biosynthesis and modifying enzymes", "Assembly of collagen fibrils and other multimeric structures", "MET activates PTK2 signaling", "Collagen chain trimerization"], "2557": ["GABA A receptor activation", "GABA receptor activation"], "255725": ["Olfactory Signaling Pathway"], "255738": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "VLDLR internalisation and degradation", "Post-translational protein phosphorylation", "LDL clearance"], "255758": ["Intraflagellar transport"], "2558": ["GABA A receptor activation", "GABA receptor activation"], "2559": ["GABA A receptor activation", "GABA receptor activation"], "255919": ["Depolymerisation of the Nuclear Lamina"], "255967": ["Deadenylation of mRNA"], "2560": ["GABA A receptor activation", "GABA receptor activation"], "256051": ["Generic Transcription Pathway"], "256076": ["Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Signaling by PDGF", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "ECM proteoglycans", "ECM proteoglycans", "NCAM1 interactions", "Collagen chain trimerization"], "2561": ["GABA A receptor activation", "GABA receptor activation"], "256126": ["Meiotic synapsis"], "256144": ["Olfactory Signaling Pathway"], "256148": ["Olfactory Signaling Pathway"], "2562": ["GABA A receptor activation", "GABA receptor activation"], "256281": ["Synthesis of dolichyl-phosphate-glucose"], "256297": ["Regulation of gene expression in early pancreatic precursor cells"], "256435": ["Sialic acid metabolism", "Termination of O-glycan biosynthesis"], "2566": ["GABA A receptor activation", "GABA receptor activation"], "2567": ["GABA A receptor activation", "GABA receptor activation"], "2569": ["GABA A (rho) receptor activation"], "256933": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "256987": ["Serine biosynthesis"], "2570": ["GABA A (rho) receptor activation"], "257062": ["Sperm Motility And Taxes"], "2571": ["GABA synthesis", "GABA synthesis, release, reuptake and degradation", "MECP2 regulates transcription of genes involved in GABA signaling"], "257106": ["Rho GTPase cycle"], "257194": ["Post-translational modification: synthesis of GPI-anchored proteins"], "2572": ["GABA synthesis", "GABA synthesis, release, reuptake and degradation", "MECP2 regulates transcription of genes involved in GABA signaling"], "257202": ["Detoxification of Reactive Oxygen Species"], "257218": ["E3 ubiquitin ligases ubiquitinate target proteins"], "257313": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "257397": ["NOD1/2 Signaling Pathway", "FCERI mediated NF-kB activation", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "activated TAK1 mediates p38 MAPK activation", "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "TNFR1-induced NFkappaB signaling pathway", "CLEC7A (Dectin-1) signaling", "TICAM1,TRAF6-dependent induction of TAK1 complex", "Interleukin-1 signaling", "IRAK2 mediated activation of TAK1 complex", "TRAF6-mediated induction of TAK1 complex within TLR4 complex", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"], "25759": ["Signalling to RAS", "Signalling to RAS", "VEGFA-VEGFR2 Pathway", "RAF/MAP kinase cascade"], "25769": ["Sodium/Calcium exchangers"], "25776": ["Deactivation of the beta-catenin transactivating complex"], "25777": ["Meiotic synapsis"], "25780": ["Activation of RAS in B cells", "Activation of RAS in B cells", "RAF/MAP kinase cascade"], "25782": ["COPI-independent Golgi-to-ER retrograde traffic", "RAB GEFs exchange GTP for GDP on RABs"], "25791": ["NRAGE signals death through JNK", "Rho GTPase cycle", "EPHA-mediated growth cone collapse", "EPHA-mediated growth cone collapse", "G alpha (12/13) signalling events"], "25793": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "25796": ["Pentose phosphate pathway"], "25797": ["Neutrophil degranulation"], "25798": ["Neutrophil degranulation"], "25799": ["Generic Transcription Pathway"], "258": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "2580": ["Golgi Associated Vesicle Biogenesis", "Clathrin-mediated endocytosis"], "25800": ["Zinc influx into cells by the SLC39 gene family"], "25801": ["Neutrophil degranulation"], "258010": ["Neutrophil degranulation"], "25802": ["Smooth Muscle Contraction"], "25804": ["mRNA decay by 5' to 3' exoribonuclease", "mRNA decay by 5' to 3' exoribonuclease", "mRNA Splicing - Major Pathway"], "25805": ["Downregulation of TGF-beta receptor signaling"], "25809": ["Carboxyterminal post-translational modifications of tubulin"], "2581": ["Glycosphingolipid metabolism"], "25813": ["Mitochondrial protein import", "Cristae formation"], "25816": ["PI Metabolism"], "25818": ["Formation of the cornified envelope", "Formation of the cornified envelope"], "25819": ["BMAL1:CLOCK,NPAS2 activates circadian gene expression"], "2582": ["Defective GALE can cause Epimerase-deficiency galactosemia (EDG)", "Galactose catabolism"], "25820": ["ISG15 antiviral mechanism"], "25821": ["tRNA modification in the mitochondrion"], "25824": ["Detoxification of Reactive Oxygen Species", "TP53 Regulates Metabolic Genes"], "25828": ["Degradation of cysteine and homocysteine", "Detoxification of Reactive Oxygen Species"], "2583": ["Glycosphingolipid metabolism"], "25830": ["Cytosolic sulfonation of small molecules"], "25831": ["Antigen processing: Ubiquitination & Proteasome degradation"], "25834": ["N-Glycan antennae elongation"], "25836": ["Cohesin Loading onto Chromatin"], "25837": ["RAB geranylgeranylation"], "25839": ["COPI-mediated anterograde transport", "Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network"], "2584": ["Defective GALK1 can cause Galactosemia II (GALCT2)", "Galactose catabolism"], "25840": ["Neutrophil degranulation"], "25842": ["Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "25847": ["Antigen processing: Ubiquitination & Proteasome degradation"], "25852": ["Neutrophil degranulation"], "25855": ["HDACs deacetylate histones"], "25862": ["Ub-specific processing proteases"], "25865": ["Sphingolipid de novo biosynthesis"], "2587": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "25870": ["Glycosphingolipid metabolism", "The activation of arylsulfatases"], "25873": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "25874": ["Pyruvate metabolism"], "25879": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol", "Neddylation"], "2588": ["Keratan sulfate degradation", "MPS IV - Morquio syndrome A", "Neutrophil degranulation"], "25885": ["NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase I Transcription Termination"], "25888": ["Cleavage of Growing Transcript in the Termination Region ", "SLBP independent Processing of Histone Pre-mRNAs", "Generic Transcription Pathway", "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"], "2589": ["COPI-independent Golgi-to-ER retrograde traffic", "O-linked glycosylation of mucins"], "25896": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes"], "25897": ["Antigen processing: Ubiquitination & Proteasome degradation"], "25898": ["Translesion Synthesis by POLH", "Antigen processing: Ubiquitination & Proteasome degradation"], "259": ["Scavenging of heme from plasma"], "2590": ["COPI-independent Golgi-to-ER retrograde traffic", "O-linked glycosylation of mucins"], "25902": ["Metabolism of folate and pterines"], "25904": ["Deadenylation of mRNA", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "25906": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6"], "25909": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "2591": ["FGFR3c ligand binding and activation", "Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)", "O-linked glycosylation of mucins"], "25913": ["Meiotic synapsis", "Packaging Of Telomere Ends", "DNA Damage/Telomere Stress Induced Senescence"], "25915": ["Complex I biogenesis"], "259173": ["RAB GEFs exchange GTP for GDP on RABs"], "259197": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "2592": ["Defective GALT can cause Galactosemia", "Galactose catabolism"], "25920": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Abortive elongation of HIV-1 transcript in the absence of Tat", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "RNA Polymerase II Transcription Elongation", "NTRK3 as a dependence receptor"], "259215": ["Platelet degranulation "], "259217": ["Regulation of HSF1-mediated heat shock response"], "259230": ["Sphingolipid de novo biosynthesis"], "259232": ["Stimuli-sensing channels"], "25924": ["Insulin processing"], "25925": ["RUNX2 regulates osteoblast differentiation"], "25926": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "259285": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "259286": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "259287": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "259289": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "25929": ["snRNP Assembly"], "259290": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "259292": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "259293": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "259294": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "259295": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "259296": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "2593": ["Creatine metabolism", "Transcriptional Regulation by MECP2"], "25930": ["Interleukin-37 signaling"], "259307": ["Phenylalanine and tyrosine catabolism"], "25936": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "25937": ["Signaling by Hippo", "YAP1- and WWTR1 (TAZ)-stimulated gene expression", "YAP1- and WWTR1 (TAZ)-stimulated gene expression", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Physiological factors", "RUNX2 regulates osteoblast differentiation", "RUNX3 regulates YAP1-mediated transcription"], "25939": ["Nucleobase catabolism", "Interferon alpha/beta signaling"], "25941": ["Carboxyterminal post-translational modifications of tubulin"], "25942": ["SUMOylation of transcription cofactors", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)", "NoRC negatively regulates rRNA expression", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Loss of MECP2 binding ability to 5mC-DNA", "Regulation of MECP2 expression and activity", "MECP2 regulates neuronal receptors and channels", "MECP2 regulates transcription of neuronal ligands", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "Factors involved in megakaryocyte development and platelet production"], "25945": ["Adherens junctions interactions", "Nectin/Necl trans heterodimerization"], "25946": ["TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "Regulation of TP53 Activity through Association with Co-factors", "Transcriptional activation of cell cycle inhibitor p21 "], "25949": ["mRNA Splicing - Major Pathway"], "25950": ["SUMO is transferred from E1 to E2 (UBE2I, UBC9)"], "2596": ["L1CAM interactions"], "25961": ["Interconversion of nucleotide di- and triphosphates"], "2597": ["Glycolysis", "Gluconeogenesis"], "25970": ["Prolactin receptor signaling", "Signaling by Leptin", "Growth hormone receptor signaling", "Factors involved in megakaryocyte development and platelet production"], "25973": ["Mitochondrial tRNA aminoacylation"], "25974": ["Cobalamin (Cbl, vitamin B12) transport and metabolism", "Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD", "Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC"], "25977": ["Golgi Associated Vesicle Biogenesis", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "25978": ["Budding and maturation of HIV virion", "Macroautophagy", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "25984": ["Keratinization", "Formation of the cornified envelope"], "25989": ["Hedgehog 'on' state"], "25994": ["Regulation of gene expression by Hypoxia-inducible Factor"], "25999": ["Regulation of TNFR1 signaling"], "26": ["Phase I - Functionalization of compounds", "Neutrophil degranulation"], "26000": ["TBC/RABGAPs"], "26003": ["Golgi Cisternae Pericentriolar Stack Reorganization"], "26005": ["Anchoring of the basal body to the plasma membrane"], "26007": ["DDX58/IFIH1-mediated induction of interferon-alpha/beta", "Fructose catabolism"], "26009": ["HATs acetylate histones"], "26013": ["Regulation of TP53 Activity through Methylation"], "26018": ["Signaling by EGFR", "Negative regulation of MET activity"], "26019": ["Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "26020": ["Retinoid metabolism and transport"], "26027": ["Mitochondrial Fatty Acid Beta-Oxidation"], "26031": ["Synthesis of bile acids and bile salts"], "26035": ["HS-GAG biosynthesis"], "26037": ["Neurexins and neuroligins"], "26043": ["Neddylation"], "26045": ["Neurexins and neuroligins"], "26046": ["Antigen processing: Ubiquitination & Proteasome degradation"], "26048": ["Generic Transcription Pathway"], "26050": ["Receptor-type tyrosine-protein phosphatases"], "26052": ["Toll Like Receptor 4 (TLR4) Cascade", "Retrograde neurotrophin signalling", "MHC class II antigen presentation", "Recycling pathway of L1", "Clathrin-mediated endocytosis"], "26053": ["RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "26060": ["Caspase activation via Dependence Receptors in the absence of ligand"], "26061": ["Alpha-oxidation of phytanate", "Peroxisomal protein import", "Peroxisomal protein import"], "26063": ["Beta-oxidation of very long chain fatty acids", "Peroxisomal protein import", "Peroxisomal protein import"], "26084": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "26085": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Formation of the cornified envelope"], "26086": ["G alpha (i) signalling events"], "26088": ["TBC/RABGAPs", "Amyloid fiber formation"], "26090": ["Arachidonate production from DAG"], "26091": ["Antigen processing: Ubiquitination & Proteasome degradation"], "26094": ["Neddylation"], "26095": ["Interleukin-37 signaling"], "26097": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA 3'-end processing"], "26100": ["Macroautophagy"], "26108": ["Formation of the beta-catenin:TCF transactivating complex", "Deactivation of the beta-catenin transactivating complex"], "26118": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "26119": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "Chylomicron clearance", "LDL clearance"], "26121": ["mRNA Splicing - Major Pathway"], "26123": ["Anchoring of the basal body to the plasma membrane"], "26127": ["Signaling by cytosolic FGFR1 fusion mutants", "Signaling by FGFR1 in disease"], "26130": ["Clathrin-mediated endocytosis", "RAB GEFs exchange GTP for GDP on RABs"], "26133": ["TRP channels"], "26140": ["Carboxyterminal post-translational modifications of tubulin"], "26146": ["Intraflagellar transport", "Intraflagellar transport"], "26147": ["PRC2 methylates histones and DNA"], "26149": ["Generic Transcription Pathway"], "26152": ["Generic Transcription Pathway"], "26153": ["MHC class II antigen presentation", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "26154": ["ABC transporters in lipid homeostasis", "Defective ABCA12 causes autosomal recessive congenital ichthyosis type 4B"], "26155": ["Regulation of TP53 Activity through Phosphorylation"], "26160": ["Hedgehog 'off' state", "Intraflagellar transport", "Intraflagellar transport"], "26166": ["G alpha (i) signalling events"], "26168": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "2617": ["Cytosolic tRNA aminoacylation", "Mitochondrial tRNA aminoacylation"], "261729": ["Transferrin endocytosis and recycling"], "26173": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes"], "261734": ["Signaling by Hippo", "Anchoring of the basal body to the plasma membrane"], "2618": ["Purine ribonucleoside monophosphate biosynthesis"], "26188": ["Olfactory Signaling Pathway"], "26189": ["Olfactory Signaling Pathway"], "2619": ["Ligand-receptor interactions", "Activation of SMO"], "26190": ["Association of TriC/CCT with target proteins during biosynthesis", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "26191": ["Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse"], "262": ["Metabolism of polyamines"], "2620": ["Caspase-mediated cleavage of cytoskeletal proteins"], "2621": ["Platelet degranulation ", "Gamma-carboxylation of protein precursors", "Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "Removal of aminoterminal propeptides from gamma-carboxylated proteins", "Cell surface interactions at the vascular wall", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "26211": ["Olfactory Signaling Pathway"], "26212": ["Olfactory Signaling Pathway"], "26219": ["Olfactory Signaling Pathway"], "2622": ["Activation of SMO"], "26224": ["Association of TriC/CCT with target proteins during biosynthesis", "Circadian Clock", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "26227": ["Serine biosynthesis"], "26229": ["A tetrasaccharide linker sequence is required for GAG synthesis", "Defective B3GAT3 causes JDSSDHD"], "2623": ["RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Factors involved in megakaryocyte development and platelet production"], "26230": ["NRAGE signals death through JNK", "Rho GTPase cycle", "PPARA activates gene expression", "G alpha (12/13) signalling events"], "26232": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "26234": ["Association of TriC/CCT with target proteins during biosynthesis", "Neddylation", "Iron uptake and transport", "Antigen processing: Ubiquitination & Proteasome degradation"], "26235": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "26239": ["Formation of the cornified envelope"], "2624": ["RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Factors involved in megakaryocyte development and platelet production"], "26245": ["Olfactory Signaling Pathway"], "26246": ["Olfactory Signaling Pathway"], "26248": ["Olfactory Signaling Pathway"], "26249": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "2625": ["Ub-specific processing proteases", "Interleukin-4 and Interleukin-13 signaling", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Factors involved in megakaryocyte development and platelet production"], "26251": ["Voltage gated Potassium channels", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion"], "26253": ["Dectin-2 family", "Dectin-2 family"], "26254": ["Degradation of the extracellular matrix"], "26258": ["Golgi Associated Vesicle Biogenesis"], "26259": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "2626": ["YAP1- and WWTR1 (TAZ)-stimulated gene expression", "Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)", "Physiological factors", "Factors involved in megakaryocyte development and platelet production"], "26263": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "26266": ["Sodium-coupled sulphate, di- and tri-carboxylate transporters"], "26267": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "26268": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "2627": ["Surfactant metabolism", "Factors involved in megakaryocyte development and platelet production"], "26270": ["Association of TriC/CCT with target proteins during biosynthesis", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "26271": ["SCF-beta-TrCP mediated degradation of Emi1", "Regulation of APC/C activators between G1/S and early anaphase", "Phosphorylation of Emi1", "Activation of E2F1 target genes at G1/S", "Mitotic Metaphase/Anaphase Transition"], "26272": ["Association of TriC/CCT with target proteins during biosynthesis", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "26275": ["Branched-chain amino acid catabolism"], "26277": ["Meiotic synapsis", "Packaging Of Telomere Ends", "DNA Damage/Telomere Stress Induced Senescence"], "26279": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PS", "Acyl chain remodelling of PE", "Acyl chain remodelling of PI", "Acyl chain remodelling of PG", "Synthesis of PA"], "2628": ["Creatine metabolism"], "26280": ["Receptor-type tyrosine-protein phosphatases"], "26281": ["PI3K Cascade", "PIP3 activates AKT signaling", "Signaling by activated point mutants of FGFR1", "Signaling by activated point mutants of FGFR3", "FGFR4 ligand binding and activation", "FGFR3b ligand binding and activation", "FGFR3c ligand binding and activation", "FGFR1c ligand binding and activation", "FGFR2c ligand binding and activation", "FGFR3 mutant receptor activation", "Activated point mutants of FGFR2", "Constitutive Signaling by Aberrant PI3K in Cancer", "Phospholipase C-mediated cascade: FGFR1", "Phospholipase C-mediated cascade; FGFR2", "Phospholipase C-mediated cascade; FGFR3", "Phospholipase C-mediated cascade; FGFR4", "Downstream signaling of activated FGFR1", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "PI-3K cascade:FGFR3", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "PI-3K cascade:FGFR4", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "Signaling by FGFR2 in disease", "Signaling by FGFR1 in disease", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Signaling by FGFR3 point mutants in cancer"], "26284": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "26285": ["Tight junction interactions"], "26286": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "26289": ["Interconversion of nucleotide di- and triphosphates"], "2629": ["Glycosphingolipid metabolism", "Association of TriC/CCT with target proteins during biosynthesis"], "26290": ["O-linked glycosylation of mucins"], "26291": ["Cellular hexose transport", "Assembly of active LPL and LIPC lipase complexes"], "2632": ["Glycogen synthesis", "Glycogen storage disease type IV (GBE1)"], "2633": ["Interferon gamma signaling"], "26330": ["Association of TriC/CCT with target proteins during biosynthesis", "Glycolysis", "Gluconeogenesis"], "26333": ["Olfactory Signaling Pathway"], "26338": ["Olfactory Signaling Pathway"], "26339": ["Olfactory Signaling Pathway"], "2634": ["Interferon gamma signaling", "Interferon alpha/beta signaling"], "26341": ["Olfactory Signaling Pathway"], "2635": ["Interferon gamma signaling"], "26353": ["HSF1-dependent transactivation"], "26354": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "2638": ["Vitamin D (calciferol) metabolism"], "2639": ["Lysine catabolism"], "2641": ["Glucagon signaling in metabolic regulation", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "G alpha (q) signalling events", "G alpha (s) signalling events", "Glucagon-type ligand receptors", "Synthesis, secretion, and deacylation of Ghrelin"], "2642": ["Glucagon signaling in metabolic regulation", "G alpha (q) signalling events", "G alpha (s) signalling events", "Glucagon-type ligand receptors"], "2643": ["Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation"], "2644": ["Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation"], "2645": ["Regulation of Glucokinase by Glucokinase Regulatory Protein", "Regulation of gene expression in beta cells", "Defective GCK causes maturity-onset diabetes of the young 2 (MODY2)", "Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)", "Glycolysis", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes"], "2646": ["Regulation of Glucokinase by Glucokinase Regulatory Protein", "Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)"], "26469": ["Downregulation of ERBB2 signaling", "Interleukin-37 signaling"], "2647": ["Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis"], "26476": ["Olfactory Signaling Pathway"], "2648": ["Pre-NOTCH Transcription and Translation", "Pre-NOTCH Transcription and Translation", "Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "NOTCH1 Intracellular Domain Regulates Transcription", "NOTCH1 Intracellular Domain Regulates Transcription", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "HATs acetylate histones", "Notch-HLH transcription pathway", "B-WICH complex positively regulates rRNA expression", "Ub-specific processing proteases", "RNA Polymerase I Transcription Initiation", "RUNX3 regulates NOTCH signaling", "RUNX3 regulates NOTCH signaling", "NOTCH3 Intracellular Domain Regulates Transcription", "NOTCH3 Intracellular Domain Regulates Transcription", "NOTCH4 Intracellular Domain Regulates Transcription"], "2649": ["POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation", "Nuclear Receptor transcription pathway"], "26492": ["Olfactory Signaling Pathway"], "26493": ["Olfactory Signaling Pathway"], "26494": ["Olfactory Signaling Pathway"], "26496": ["Olfactory Signaling Pathway"], "265": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "2650": ["O-linked glycosylation of mucins"], "26503": ["Sialic acid metabolism", "Organic anion transporters", "Defective SLC17A5 causes Salla disease (SD) and ISSD"], "26508": ["NOTCH1 Intracellular Domain Regulates Transcription", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "NOTCH3 Intracellular Domain Regulates Transcription"], "26512": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes"], "26515": ["Mitochondrial protein import"], "26517": ["Mitochondrial protein import"], "26519": ["Mitochondrial protein import", "Mitochondrial protein import"], "2652": ["The retinoid cycle in cones (daylight vision)", "Retinoid cycle disease events", "G alpha (i) signalling events", "Opsins"], "26520": ["Mitochondrial protein import", "Mitochondrial protein import"], "26521": ["Mitochondrial protein import"], "26523": ["Pre-NOTCH Transcription and Translation", "MicroRNA (miRNA) biogenesis", "Oxidative Stress Induced Senescence", "Oncogene Induced Senescence", "Ca2+ pathway", "Small interfering RNA (siRNA) biogenesis", "Post-transcriptional silencing by small RNAs", "Transcriptional regulation by small RNAs", "TP53 Regulates Metabolic Genes", "MAPK6/MAPK4 signaling", "Regulation of RUNX1 Expression and Activity", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Regulation of PTEN mRNA translation", "Competing endogenous RNAs (ceRNAs) regulate PTEN translation", "Transcriptional Regulation by MECP2", "Transcriptional Regulation by MECP2", "Estrogen-dependent gene expression", "Regulation of MECP2 expression and activity"], "26524": ["Signaling by Hippo"], "26525": ["Interleukin-36 pathway"], "26529": ["Olfactory Signaling Pathway"], "2653": ["Glyoxylate metabolism and glycine degradation", "Glycine degradation"], "26531": ["Olfactory Signaling Pathway"], "26532": ["Olfactory Signaling Pathway"], "26533": ["Olfactory Signaling Pathway"], "26538": ["Olfactory Signaling Pathway"], "26539": ["Olfactory Signaling Pathway"], "2657": ["Signaling by NODAL"], "26574": ["NRAGE signals death through JNK"], "26575": ["G alpha (q) signalling events", "G alpha (i) signalling events", "G alpha (z) signalling events", "G alpha (z) signalling events"], "26577": ["Collagen biosynthesis and modifying enzymes"], "26578": ["Neutrophil degranulation"], "2658": ["Signaling by BMP"], "26589": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "26595": ["Olfactory Signaling Pathway"], "2660": ["FOXO-mediated transcription of cell cycle genes"], "26610": ["HATs acetylate histones"], "2664": ["Rho GTPase cycle", "RAB GEFs exchange GTP for GDP on RABs"], "26648": ["Olfactory Signaling Pathway"], "2665": ["Rho GTPase cycle", "Neutrophil degranulation", "RAB GEFs exchange GTP for GDP on RABs"], "26658": ["Olfactory Signaling Pathway"], "26659": ["Olfactory Signaling Pathway"], "26664": ["Olfactory Signaling Pathway"], "266675": ["Stimuli-sensing channels"], "266722": ["HS-GAG biosynthesis"], "266727": ["Post-translational modification: synthesis of GPI-anchored proteins"], "2668": ["NCAM1 interactions", "RAF/MAP kinase cascade", "RET signaling"], "26682": ["Olfactory Signaling Pathway"], "26683": ["Olfactory Signaling Pathway"], "26687": ["Olfactory Signaling Pathway"], "26689": ["Olfactory Signaling Pathway"], "26692": ["Olfactory Signaling Pathway"], "26693": ["Olfactory Signaling Pathway"], "26696": ["Olfactory Signaling Pathway"], "267": ["N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "ER Quality Control Compartment (ERQC)"], "2670": ["Nuclear signaling by ERBB4"], "26707": ["Olfactory Signaling Pathway"], "2671": ["Mitochondrial protein import"], "26716": ["Olfactory Signaling Pathway"], "2673": ["XBP1(S) activates chaperone genes", "Defective GFPT1 causes CMSTA1", "Synthesis of UDP-N-acetyl-glucosamine"], "26735": ["Olfactory Signaling Pathway"], "26737": ["Olfactory Signaling Pathway"], "2674": ["NCAM1 interactions", "RAF/MAP kinase cascade", "RET signaling"], "26740": ["Olfactory Signaling Pathway"], "2675": ["NCAM1 interactions", "RAF/MAP kinase cascade", "RET signaling"], "2676": ["RAF/MAP kinase cascade", "RET signaling"], "2677": ["Gamma-carboxylation of protein precursors", "Gamma-carboxylation of protein precursors"], "2678": ["Glutathione synthesis and recycling", "Synthesis of Leukotrienes (LT) and Eoxins (EX)", "Aflatoxin activation and detoxification", "Defective GGT1 causes Glutathionuria (GLUTH)", "Defective GGT1 causes Glutathionuria (GLUTH)"], "268": ["Signaling by BMP"], "2683": ["Interaction With The Zona Pellucida", "Pre-NOTCH Processing in Golgi", "Keratan sulfate biosynthesis", "Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)", "Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)", "Lactose synthesis", "Neutrophil degranulation", "N-Glycan antennae elongation"], "2686": ["Glutathione synthesis and recycling", "Aflatoxin activation and detoxification"], "2687": ["Glutathione synthesis and recycling", "Synthesis of Leukotrienes (LT) and Eoxins (EX)", "Aflatoxin activation and detoxification"], "26873": ["Glutathione synthesis and recycling", "Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD)"], "2688": ["Prolactin receptor signaling", "Prolactin receptor signaling", "Synthesis, secretion, and deacylation of Ghrelin", "Growth hormone receptor signaling", "Growth hormone receptor signaling"], "2689": ["Prolactin receptor signaling", "Prolactin receptor signaling", "Growth hormone receptor signaling", "Growth hormone receptor signaling"], "269": ["Signaling by BMP"], "2690": ["Prolactin receptor signaling", "Growth hormone receptor signaling", "Growth hormone receptor signaling"], "2691": ["G alpha (s) signalling events", "Glucagon-type ligand receptors"], "2692": ["G alpha (s) signalling events", "Glucagon-type ligand receptors"], "2693": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "2694": ["Cobalamin (Cbl, vitamin B12) transport and metabolism", "Defective GIF causes intrinsic factor deficiency", "Defective AMN causes hereditary megaloblastic anemia 1", "Defective CUBN causes hereditary megaloblastic anemia 1"], "2695": ["Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)", "Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)", "G alpha (s) signalling events", "Glucagon-type ligand receptors"], "26958": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "2696": ["G alpha (s) signalling events", "Glucagon-type ligand receptors"], "2697": ["Oligomerization of connexins into connexons", "Transport of connexins along the secretory pathway", "Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "Gap junction assembly", "Gap junction assembly", "Gap junction degradation", "c-src mediated regulation of Cx43 function and closure of gap junctions", "c-src mediated regulation of Cx43 function and closure of gap junctions", "Formation of annular gap junctions"], "26974": ["Generic Transcription Pathway"], "26984": ["COPII-mediated vesicle transport"], "26985": ["Association of TriC/CCT with target proteins during biosynthesis"], "26986": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Deadenylation of mRNA", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Translation initiation complex formation", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "26999": ["Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs"], "27": ["Role of ABL in ROBO-SLIT signaling", "Role of ABL in ROBO-SLIT signaling"], "270": ["Purine salvage"], "2700": ["Gap junction assembly"], "27000": ["Regulation of HSF1-mediated heat shock response"], "27005": ["TNFR1-induced proapoptotic signaling", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "Ub-specific processing proteases"], "27006": ["PI3K Cascade", "PIP3 activates AKT signaling", "FGFR1b ligand binding and activation", "FGFR2b ligand binding and activation", "Activated point mutants of FGFR2", "Constitutive Signaling by Aberrant PI3K in Cancer", "Phospholipase C-mediated cascade: FGFR1", "Phospholipase C-mediated cascade; FGFR2", "Downstream signaling of activated FGFR1", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Signaling by FGFR2 in disease", "FGFRL1 modulation of FGFR1 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "2701": ["Gap junction assembly"], "27010": ["Vitamin B1 (thiamin) metabolism"], "27012": ["Voltage gated Potassium channels"], "27018": ["NADE modulates death signalling"], "2702": ["Gap junction assembly"], "27020": ["GABA receptor activation"], "27022": ["POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation"], "2703": ["Gap junction assembly"], "27030": ["Meiotic recombination"], "27031": ["Trafficking of myristoylated proteins to the cilium"], "27032": ["Ion transport by P-type ATPases"], "27033": ["Recognition of DNA damage by PCNA-containing replication complex"], "27034": ["Branched-chain amino acid catabolism"], "27035": ["RHO GTPases Activate NADPH Oxidases"], "27036": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "27040": ["GPVI-mediated activation cascade", "Generation of second messenger molecules", "DAP12 signaling", "Fc epsilon receptor (FCERI) signaling", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "RAF/MAP kinase cascade"], "27042": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "27043": ["Major pathway of rRNA processing in the nucleolus and cytosol", "PTK6 Expression"], "27044": ["Signaling by BRAF and RAF fusions"], "2705": ["Oligomerization of connexins into connexons", "Oligomerization of connexins into connexons", "Transport of connexins along the secretory pathway", "Gap junction assembly"], "2706": ["Oligomerization of connexins into connexons", "Transport of connexins along the secretory pathway", "Gap junction assembly", "Transport of connexons to the plasma membrane"], "27063": ["PPARA activates gene expression"], "27068": ["Mitochondrial tRNA aminoacylation", "Pyrophosphate hydrolysis"], "2707": ["Gap junction assembly"], "27071": ["Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "27076": ["Post-translational modification: synthesis of GPI-anchored proteins"], "27077": ["Anchoring of the basal body to the plasma membrane"], "27086": ["Transcriptional regulation of pluripotent stem cells"], "27087": ["A tetrasaccharide linker sequence is required for GAG synthesis"], "27089": ["Respiratory electron transport"], "2709": ["Gap junction assembly"], "27090": ["Sialic acid metabolism", "Termination of O-glycan biosynthesis"], "27091": ["Phase 0 - rapid depolarisation", "Phase 2 - plateau phase"], "27092": ["Presynaptic depolarization and calcium channel opening", "Trafficking of AMPA receptors", "Phase 0 - rapid depolarisation", "Phase 2 - plateau phase", "LGI-ADAM interactions"], "27094": ["Ca2+ activated K+ channels", "cGMP effects"], "27095": ["COPII-mediated vesicle transport", "RAB GEFs exchange GTP for GDP on RABs"], "27097": ["HATs acetylate histones"], "271": ["Purine salvage"], "2710": ["Triglyceride biosynthesis"], "27109": ["Formation of ATP by chemiosmotic coupling", "Cristae formation"], "27113": ["BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "Activation of PUMA and translocation to mitochondria", "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "FOXO-mediated transcription of cell death genes"], "27115": ["G alpha (s) signalling events"], "2712": ["Triglyceride biosynthesis"], "27121": ["TCF dependent signaling in response to WNT", "Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling"], "27123": ["TCF dependent signaling in response to WNT", "Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling"], "27124": ["Synthesis of PIPs at the plasma membrane", "Synthesis of IP2, IP, and Ins in the cytosol", "Synthesis of IP3 and IP4 in the cytosol"], "27125": ["Formation of RNA Pol II elongation complex ", "RNA Polymerase II Pre-transcription Events", "RNA Polymerase II Transcription Elongation"], "27127": ["Meiotic synapsis"], "27128": ["Intra-Golgi traffic"], "27131": ["Golgi Associated Vesicle Biogenesis"], "27132": ["Glycerophospholipid biosynthesis"], "27133": ["Voltage gated Potassium channels"], "27147": ["RAB GEFs exchange GTP for GDP on RABs"], "27152": ["Hedgehog 'off' state"], "27153": ["Generic Transcription Pathway"], "27154": ["Platelet degranulation ", "HATs acetylate histones", "Regulation of TP53 Activity through Acetylation"], "27158": ["Cytosolic iron-sulfur cluster assembly"], "27159": ["Digestion of dietary carbohydrate"], "27161": ["Pre-NOTCH Transcription and Translation", "MicroRNA (miRNA) biogenesis", "Ca2+ pathway", "Small interfering RNA (siRNA) biogenesis", "Post-transcriptional silencing by small RNAs", "Transcriptional regulation by small RNAs", "TP53 Regulates Metabolic Genes", "MAPK6/MAPK4 signaling", "Regulation of RUNX1 Expression and Activity", "Regulation of PTEN mRNA translation", "Competing endogenous RNAs (ceRNAs) regulate PTEN translation", "Transcriptional Regulation by MECP2", "Transcriptional Regulation by MECP2", "Estrogen-dependent gene expression", "Regulation of MECP2 expression and activity"], "27163": ["Neurotransmitter release cycle"], "27165": ["Glutamate Neurotransmitter Release Cycle", "TP53 Regulates Metabolic Genes", "Amino acid synthesis and interconversion (transamination)"], "27166": ["TP53 Regulates Transcription of Genes Involved in Cytochrome C Release"], "2717": ["Glycosphingolipid metabolism", "Neutrophil degranulation"], "27173": ["Zinc influx into cells by the SLC39 gene family"], "27175": ["Recruitment of mitotic centrosome proteins and complexes", "Recruitment of NuMA to mitotic centrosomes"], "27177": ["Interleukin-36 pathway"], "27178": ["Interleukin-37 signaling", "Interleukin-18 signaling"], "27179": ["Interleukin-36 pathway"], "27180": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation"], "27181": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "27183": ["Budding and maturation of HIV virion", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "27189": ["Interleukin-17 signaling"], "2719": ["A tetrasaccharide linker sequence is required for GAG synthesis", "HS-GAG biosynthesis", "HS-GAG biosynthesis", "HS-GAG degradation", "Defective B4GALT7 causes EDS, progeroid type", "Defective B3GAT3 causes JDSSDHD", "Defective EXT2 causes exostoses 2", "Defective EXT1 causes exostoses 1, TRPS2 and CHDS", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Defective B3GALT6 causes EDSP2 and SEMDJL1", "Post-translational protein phosphorylation", "Retinoid metabolism and transport"], "27198": ["Hydroxycarboxylic acid-binding receptors", "G alpha (i) signalling events"], "27199": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (i) signalling events"], "272": ["Neutrophil degranulation", "Purine salvage"], "2720": ["Glycosphingolipid metabolism", "Keratan sulfate degradation", "HS-GAG degradation", "MPS IV - Morquio syndrome B", "Sialic acid metabolism", "Neutrophil degranulation"], "27202": ["Peptide ligand-binding receptors", "Regulation of Complement cascade"], "27229": ["Recruitment of mitotic centrosome proteins and complexes", "Recruitment of NuMA to mitotic centrosomes"], "27230": ["XBP1(S) activates chaperone genes"], "27231": ["Nicotinate metabolism"], "27232": ["Metabolism of ingested SeMet, Sec, MeSec into H2Se", "Glyoxylate metabolism and glycine degradation"], "27233": ["Cytosolic sulfonation of small molecules"], "27237": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "27238": ["mRNA Splicing - Major Pathway"], "27241": ["BBSome-mediated cargo-targeting to cilium"], "27242": ["PPARA activates gene expression"], "27243": ["Budding and maturation of HIV virion", "Macroautophagy", "Lysosome Vesicle Biogenesis", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "27244": ["TP53 Regulates Metabolic Genes"], "27246": ["Antigen processing: Ubiquitination & Proteasome degradation"], "27248": ["ABC-family proteins mediated transport", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Defective CFTR causes cystic fibrosis"], "27249": ["Cobalamin (Cbl, vitamin B12) transport and metabolism", "Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD"], "27250": ["Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "27252": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "27255": ["CHL1 interactions"], "27257": ["mRNA decay by 5' to 3' exoribonuclease", "mRNA decay by 5' to 3' exoribonuclease"], "27258": ["mRNA decay by 5' to 3' exoribonuclease", "mRNA decay by 5' to 3' exoribonuclease", "mRNA Splicing - Major Pathway"], "27284": ["Cytosolic sulfonation of small molecules"], "27289": ["SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "Sema4D mediated inhibition of cell attachment and migration", "Sema4D induced cell migration and growth-cone collapse"], "2729": ["Glutathione synthesis and recycling", "Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)"], "27292": ["rRNA modification in the nucleus and cytosol"], "27297": ["Cytosolic sensors of pathogen-associated DNA ", "RNA Polymerase III Chain Elongation", "RNA Polymerase III Transcription Termination", "RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "273": ["Clathrin-mediated endocytosis"], "2730": ["Glutathione synthesis and recycling"], "27300": ["Generic Transcription Pathway"], "27302": ["Signaling by BMP", "Molecules associated with elastic fibres"], "27304": ["Molybdenum cofactor biosynthesis"], "27306": ["Glutathione conjugation", "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"], "2731": ["Glycine degradation"], "27314": ["Intra-Golgi traffic", "RAB geranylgeranylation"], "27316": ["mRNA Splicing - Major Pathway", "Processing of Capped Intron-Containing Pre-mRNA"], "27327": ["Pre-NOTCH Transcription and Translation", "Oxidative Stress Induced Senescence", "Oncogene Induced Senescence", "Ca2+ pathway", "Post-transcriptional silencing by small RNAs", "Transcriptional regulation by small RNAs", "TP53 Regulates Metabolic Genes", "MAPK6/MAPK4 signaling", "Regulation of RUNX1 Expression and Activity", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Regulation of PTEN mRNA translation", "Competing endogenous RNAs (ceRNAs) regulate PTEN translation", "Transcriptional Regulation by MECP2", "Transcriptional Regulation by MECP2", "Estrogen-dependent gene expression", "Regulation of MECP2 expression and activity"], "27329": ["Assembly of active LPL and LIPC lipase complexes"], "2733": ["Transport of Mature mRNA derived from an Intron-Containing Transcript"], "27330": ["Recycling pathway of L1", "CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling", "RSK activation", "RSK activation"], "27332": ["Transcriptional regulation of white adipocyte differentiation"], "27333": ["Intra-Golgi traffic"], "27334": ["G alpha (q) signalling events", "P2Y receptors"], "27335": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "27338": ["Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Antigen processing: Ubiquitination & Proteasome degradation"], "27339": ["Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "mRNA Splicing - Major Pathway"], "2734": ["Cell surface interactions at the vascular wall"], "27340": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "27341": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "27342": ["TBC/RABGAPs", "RAB GEFs exchange GTP for GDP on RABs"], "27343": ["Nonhomologous End-Joining (NHEJ)"], "27345": ["Ca2+ activated K+ channels", "cGMP effects"], "27348": ["Cargo recognition for clathrin-mediated endocytosis"], "27349": ["Mitochondrial Fatty Acid Beta-Oxidation"], "2735": ["Degradation of GLI1 by the proteasome", "Degradation of GLI1 by the proteasome", "Hedgehog 'off' state", "Hedgehog 'on' state", "GLI proteins bind promoters of Hh responsive genes to promote transcription"], "27350": ["mRNA Editing: C to U Conversion", "Formation of the Editosome"], "2736": ["Degradation of GLI2 by the proteasome", "Hedgehog 'off' state", "Hedgehog 'on' state", "GLI proteins bind promoters of Hh responsive genes to promote transcription", "RUNX2 regulates chondrocyte maturation"], "2737": ["GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'off' state", "Hedgehog 'on' state", "GLI proteins bind promoters of Hh responsive genes to promote transcription", "RUNX2 regulates osteoblast differentiation"], "2739": ["Pyruvate metabolism"], "274": ["Clathrin-mediated endocytosis"], "2740": ["Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "G alpha (s) signalling events", "Glucagon-type ligand receptors"], "2741": ["Neurotransmitter receptors and postsynaptic signal transmission"], "2742": ["Neurotransmitter receptors and postsynaptic signal transmission"], "2743": ["Neurotransmitter receptors and postsynaptic signal transmission"], "27430": ["Methylation", "Ub-specific processing proteases"], "27434": ["Nonhomologous End-Joining (NHEJ)"], "2744": ["Glutamate Neurotransmitter Release Cycle", "TP53 Regulates Metabolic Genes", "Amino acid synthesis and interconversion (transamination)"], "2745": ["Interconversion of nucleotide di- and triphosphates"], "2746": ["Transcriptional activation of mitochondrial biogenesis", "Amino acid synthesis and interconversion (transamination)"], "2747": ["Transcriptional activation of mitochondrial biogenesis", "Amino acid synthesis and interconversion (transamination)"], "275": ["Glycine degradation"], "2752": ["Astrocytic Glutamate-Glutamine Uptake And Metabolism", "Amino acid synthesis and interconversion (transamination)"], "276": ["Digestion of dietary carbohydrate"], "2760": ["Glycosphingolipid metabolism", "Neutrophil degranulation"], "2762": ["GDP-fucose biosynthesis"], "2766": ["Purine salvage"], "2767": ["Acetylcholine regulates insulin secretion", "Acetylcholine regulates insulin secretion", "G alpha (q) signalling events", "G alpha (q) signalling events", "ADP signalling through P2Y purinoceptor 1", "ADP signalling through P2Y purinoceptor 1", "Thromboxane signalling through TP receptor", "Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "Thrombin signalling through proteinase activated receptors (PARs)"], "2768": ["G alpha (12/13) signalling events", "Thrombin signalling through proteinase activated receptors (PARs)", "Thrombin signalling through proteinase activated receptors (PARs)"], "2769": ["Acetylcholine regulates insulin secretion", "Acetylcholine regulates insulin secretion", "G alpha (q) signalling events", "G alpha (q) signalling events", "ADP signalling through P2Y purinoceptor 1", "ADP signalling through P2Y purinoceptor 1", "Thromboxane signalling through TP receptor", "Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "Thrombin signalling through proteinase activated receptors (PARs)"], "277": ["Digestion of dietary carbohydrate"], "2770": ["PLC beta mediated events", "PLC beta mediated events", "Adenylate cyclase inhibitory pathway", "Adenylate cyclase inhibitory pathway", "G-protein activation", "ADP signalling through P2Y purinoceptor 12", "Adrenaline,noradrenaline inhibits insulin secretion", "Adrenaline,noradrenaline inhibits insulin secretion", "G alpha (s) signalling events", "G alpha (i) signalling events", "G alpha (i) signalling events", "G alpha (z) signalling events", "Regulation of insulin secretion", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "2771": ["PLC beta mediated events", "PLC beta mediated events", "Adenylate cyclase inhibitory pathway", "Adenylate cyclase inhibitory pathway", "G-protein activation", "ADP signalling through P2Y purinoceptor 12", "Adrenaline,noradrenaline inhibits insulin secretion", "Adrenaline,noradrenaline inhibits insulin secretion", "G alpha (s) signalling events", "G alpha (i) signalling events", "G alpha (i) signalling events", "G alpha (z) signalling events", "Regulation of insulin secretion", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "2773": ["PLC beta mediated events", "PLC beta mediated events", "Adenylate cyclase inhibitory pathway", "Adenylate cyclase inhibitory pathway", "G-protein activation", "ADP signalling through P2Y purinoceptor 12", "G alpha (s) signalling events", "G alpha (i) signalling events", "G alpha (i) signalling events", "G alpha (z) signalling events", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "2774": ["Adenylate cyclase activating pathway", "Adenylate cyclase inhibitory pathway", "Olfactory Signaling Pathway"], "2775": ["PLC beta mediated events", "PLC beta mediated events", "G-protein activation", "Ca2+ pathway", "Ca2+ pathway", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "2776": ["Acetylcholine regulates insulin secretion", "Acetylcholine regulates insulin secretion", "G alpha (q) signalling events", "G alpha (q) signalling events", "ADP signalling through P2Y purinoceptor 1", "ADP signalling through P2Y purinoceptor 1", "Thromboxane signalling through TP receptor", "Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "Thrombin signalling through proteinase activated receptors (PARs)"], "2778": ["Glucagon signaling in metabolic regulation", "PKA activation in glucagon signalling", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Prostacyclin signalling through prostacyclin receptor", "Prostacyclin signalling through prostacyclin receptor", "G alpha (s) signalling events", "G alpha (s) signalling events", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Vasopressin regulates renal water homeostasis via Aquaporins", "Hedgehog 'off' state"], "2779": ["PLC beta mediated events", "PLC beta mediated events", "G-protein activation", "Activation of the phototransduction cascade", "Activation of the phototransduction cascade", "Inactivation, recovery and regulation of the phototransduction cascade", "Inactivation, recovery and regulation of the phototransduction cascade", "G alpha (i) signalling events", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "278": ["Digestion of dietary carbohydrate"], "2780": ["PLC beta mediated events", "PLC beta mediated events", "G-protein activation", "Ca2+ pathway", "Ca2+ pathway", "G alpha (i) signalling events", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "2781": ["PLC beta mediated events", "PLC beta mediated events", "G-protein activation", "G alpha (s) signalling events", "G alpha (i) signalling events", "G alpha (z) signalling events", "G alpha (z) signalling events", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "2782": ["Activation of G protein gated Potassium channels", "Glucagon signaling in metabolic regulation", "G-protein activation", "Activation of the phototransduction cascade", "Activation of the phototransduction cascade", "Inactivation, recovery and regulation of the phototransduction cascade", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Olfactory Signaling Pathway", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42", "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "2783": ["Activation of G protein gated Potassium channels", "Glucagon signaling in metabolic regulation", "G-protein activation", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42", "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "2784": ["Activation of G protein gated Potassium channels", "Glucagon signaling in metabolic regulation", "G-protein activation", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42", "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "2785": ["Activation of G protein gated Potassium channels", "Glucagon signaling in metabolic regulation", "G-protein activation", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42", "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "2786": ["Activation of G protein gated Potassium channels", "Glucagon signaling in metabolic regulation", "G-protein activation", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42", "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "2787": ["Activation of G protein gated Potassium channels", "Glucagon signaling in metabolic regulation", "G-protein activation", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42", "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "2788": ["Activation of G protein gated Potassium channels", "Glucagon signaling in metabolic regulation", "G-protein activation", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42", "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "279": ["Digestion of dietary carbohydrate"], "2790": ["Activation of G protein gated Potassium channels", "Glucagon signaling in metabolic regulation", "G-protein activation", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42", "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "2791": ["Glucagon signaling in metabolic regulation", "G-protein activation", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42"], "2792": ["Activation of G protein gated Potassium channels", "G-protein activation", "Activation of the phototransduction cascade", "Activation of the phototransduction cascade", "Inactivation, recovery and regulation of the phototransduction cascade", "Inactivation, recovery and regulation of the phototransduction cascade", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Olfactory Signaling Pathway", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42", "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "2793": ["Activation of G protein gated Potassium channels", "G-protein activation", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42", "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "2796": ["Hormone ligand-binding receptors", "G alpha (q) signalling events"], "2797": ["Hormone ligand-binding receptors", "G alpha (q) signalling events"], "2798": ["Hormone ligand-binding receptors", "G alpha (q) signalling events"], "2799": ["Keratan sulfate degradation", "MPS IIID - Sanfilippo syndrome D", "Lysosome Vesicle Biogenesis", "Neutrophil degranulation"], "280": ["Digestion of dietary carbohydrate"], "2800": ["Retrograde transport at the Trans-Golgi-Network"], "2801": ["Golgi Cisternae Pericentriolar Stack Reorganization", "Golgi Cisternae Pericentriolar Stack Reorganization", "COPII-mediated vesicle transport", "COPI-mediated anterograde transport", "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models"], "2803": ["Retrograde transport at the Trans-Golgi-Network"], "2804": ["Golgi Associated Vesicle Biogenesis", "COPI-mediated anterograde transport"], "2805": ["Methionine salvage pathway", "Gluconeogenesis", "Amino acid synthesis and interconversion (transamination)"], "2806": ["Degradation of cysteine and homocysteine", "Glyoxylate metabolism and glycine degradation", "Gluconeogenesis", "Amino acid synthesis and interconversion (transamination)"], "2810": ["Activation of BAD and translocation to mitochondria ", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "RHO GTPases activate PKNs", "TP53 Regulates Metabolic Genes", "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "Regulation of localization of FOXO transcription factors"], "2811": ["Intrinsic Pathway of Fibrin Clot Formation", "GP1b-IX-V activation signalling", "Platelet Adhesion to exposed collagen", "Platelet Aggregation (Plug Formation)", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"], "2812": ["Intrinsic Pathway of Fibrin Clot Formation", "GP1b-IX-V activation signalling", "Platelet Adhesion to exposed collagen", "Platelet Aggregation (Plug Formation)"], "2813": ["Post-translational modification: synthesis of GPI-anchored proteins"], "2814": ["Intrinsic Pathway of Fibrin Clot Formation", "GP1b-IX-V activation signalling", "Platelet Adhesion to exposed collagen", "Platelet Aggregation (Plug Formation)"], "2815": ["Intrinsic Pathway of Fibrin Clot Formation", "GP1b-IX-V activation signalling", "Platelet Adhesion to exposed collagen", "Platelet Aggregation (Plug Formation)"], "2817": ["A tetrasaccharide linker sequence is required for GAG synthesis", "HS-GAG biosynthesis", "HS-GAG biosynthesis", "HS-GAG degradation", "Cell surface interactions at the vascular wall", "Defective B4GALT7 causes EDS, progeroid type", "Defective B3GAT3 causes JDSSDHD", "Defective EXT2 causes exostoses 2", "Defective EXT1 causes exostoses 1, TRPS2 and CHDS", "Signaling by ROBO receptors", "Defective B3GALT6 causes EDSP2 and SEMDJL1", "Retinoid metabolism and transport"], "2819": ["Synthesis of PA"], "2820": ["Synthesis of PA", "Triglyceride catabolism"], "2821": ["TP53 Regulates Metabolic Genes", "Neutrophil degranulation", "Glycolysis", "Gluconeogenesis"], "2822": ["Post-translational modification: synthesis of GPI-anchored proteins"], "28227": ["Inhibition of replication initiation of damaged DNA by RB1/E2F1", "Cyclin D associated events in G1", "Cyclin A/B1/B2 associated events during G2/M transition"], "28231": ["Transport of organic anions"], "28232": ["Transport of organic anions"], "28234": ["Recycling of bile acids and salts", "Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR)", "Transport of organic anions"], "2826": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "282616": ["Interleukin-20 family signaling"], "282617": ["Interleukin-20 family signaling"], "282618": ["Other interleukin signaling", "Interleukin-20 family signaling"], "282679": ["Passive transport by Aquaporins"], "282763": ["Olfactory Signaling Pathway"], "282770": ["Olfactory Signaling Pathway"], "282775": ["Olfactory Signaling Pathway"], "2828": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (q) signalling events"], "282890": ["Generic Transcription Pathway"], "2829": ["Chemokine receptors bind chemokines", "G alpha (q) signalling events"], "282969": ["GDP-fucose biosynthesis"], "283": ["Adherens junctions interactions"], "283092": ["Olfactory Signaling Pathway"], "283093": ["Olfactory Signaling Pathway"], "2831": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "283110": ["Olfactory Signaling Pathway"], "283111": ["Olfactory Signaling Pathway"], "283149": ["Formation of the beta-catenin:TCF transactivating complex", "Deactivation of the beta-catenin transactivating complex"], "283159": ["Olfactory Signaling Pathway"], "283160": ["Olfactory Signaling Pathway"], "283162": ["Olfactory Signaling Pathway"], "283189": ["Olfactory Signaling Pathway"], "2832": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "283208": ["Collagen biosynthesis and modifying enzymes"], "283209": ["Glycogen synthesis", "Glycolysis", "Glycogen breakdown (glycogenolysis)", "Galactose catabolism"], "283297": ["Olfactory Signaling Pathway"], "2833": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "283337": ["Generic Transcription Pathway"], "283365": ["Olfactory Signaling Pathway"], "283375": ["Zinc influx into cells by the SLC39 gene family"], "2834": ["Peptide ligand-binding receptors"], "283455": ["MAP2K and MAPK activation", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF"], "283463": ["Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)", "Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)", "Defective GALNT12 causes colorectal cancer 1 (CRCS1)", "Dectin-2 family", "O-linked glycosylation of mucins", "Termination of O-glycan biosynthesis"], "283652": ["Sodium/Calcium exchangers", "Defective SLC24A5 causes oculocutaneous albinism 6 (OCA6)"], "283694": ["Olfactory Signaling Pathway"], "2837": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "283742": ["tRNA processing in the nucleus"], "283748": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PS", "Acyl chain remodelling of PE", "Acyl chain remodelling of PI", "Acyl chain remodelling of PG", "Hydrolysis of LPC", "Synthesis of PA"], "2838": ["G alpha (s) signalling events"], "283807": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "283869": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "283871": ["Glycolysis"], "283899": ["UCH proteinases", "DNA Damage Recognition in GG-NER"], "283927": ["Peroxisomal lipid metabolism", "Peroxisomal protein import", "Peroxisomal protein import"], "283989": ["tRNA processing in the nucleus"], "284": ["Tie2 Signaling", "Tie2 Signaling", "RAF/MAP kinase cascade"], "2840": ["Leukotriene receptors", "G alpha (q) signalling events", "P2Y receptors", "G alpha (i) signalling events"], "284058": ["HATs acetylate histones"], "284076": ["Carboxyterminal post-translational modifications of tubulin"], "284098": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "2841": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (i) signalling events"], "284111": ["Sodium-coupled sulphate, di- and tri-carboxylate transporters"], "284119": ["RNA Polymerase I Transcription Termination"], "284129": ["Multifunctional anion exchangers"], "284161": ["Glycerophospholipid catabolism"], "284217": ["Laminin interactions", "Laminin interactions", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "L1CAM interactions", "MET activates PTK2 signaling"], "284252": ["Negative regulation of activity of TFAP2 (AP-2) family transcription factors"], "284266": ["DAP12 interactions"], "284297": ["Scavenging by Class B Receptors"], "2843": ["G alpha (s) signalling events"], "284306": ["Generic Transcription Pathway"], "284307": ["Generic Transcription Pathway"], "284309": ["Generic Transcription Pathway"], "284348": ["Post-translational modification: synthesis of GPI-anchored proteins"], "284359": ["Sperm:Oocyte Membrane Binding"], "284370": ["Generic Transcription Pathway"], "284383": ["Olfactory Signaling Pathway"], "284433": ["Olfactory Signaling Pathway"], "284443": ["Generic Transcription Pathway"], "284459": ["Generic Transcription Pathway"], "284486": ["Mitochondrial Fatty Acid Beta-Oxidation"], "284521": ["Olfactory Signaling Pathway"], "284525": ["Stimuli-sensing channels"], "284532": ["Olfactory Signaling Pathway"], "284541": ["Fatty acids", "Miscellaneous substrates", "Eicosanoids", "Synthesis of Leukotrienes (LT) and Eoxins (EX)"], "2846": ["G alpha (q) signalling events", "P2Y receptors"], "284654": ["Regulation of FZD by ubiquitination"], "284656": ["EPH-Ephrin signaling", "EPH-Ephrin signaling", "EPHA-mediated growth cone collapse", "EPHA-mediated growth cone collapse", "EPH-ephrin mediated repulsion of cells", "EPH-ephrin mediated repulsion of cells"], "2847": ["Peptide ligand-binding receptors", "G alpha (q) signalling events", "G alpha (i) signalling events", "BBSome-mediated cargo-targeting to cilium"], "284716": ["Amino acid synthesis and interconversion (transamination)"], "2848": ["G alpha (s) signalling events"], "284827": ["Keratinization"], "285": ["Tie2 Signaling"], "2850": ["G alpha (s) signalling events"], "285093": ["Olfactory Signaling Pathway"], "28511": ["RIP-mediated NFkB activation via ZBP1", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "TRAF6 mediated NF-kB activation"], "28512": ["RIP-mediated NFkB activation via ZBP1", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "TRAF6 mediated NF-kB activation"], "28514": ["Activated NOTCH1 Transmits Signal to the Nucleus", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant", "Constitutive Signaling by NOTCH1 HD Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "NOTCH2 Activation and Transmission of Signal to the Nucleus", "NOTCH3 Activation and Transmission of Signal to the Nucleus", "NOTCH3 Activation and Transmission of Signal to the Nucleus", "MECP2 regulates transcription of neuronal ligands"], "285175": ["Stimuli-sensing channels"], "285195": ["Sodium/Proton exchangers", "Defective SLC9A9 causes autism 16 (AUTS16)"], "2852": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "285220": ["EPH-Ephrin signaling", "EPH-Ephrin signaling", "EPHA-mediated growth cone collapse", "EPHA-mediated growth cone collapse", "EPH-ephrin mediated repulsion of cells", "EPH-ephrin mediated repulsion of cells"], "285231": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "285242": ["Neurotransmitter receptors and postsynaptic signal transmission"], "285267": ["Generic Transcription Pathway"], "285268": ["Generic Transcription Pathway"], "2853": ["G alpha (i) signalling events", "Free fatty acid receptors"], "285335": ["Stimuli-sensing channels"], "285349": ["Generic Transcription Pathway"], "285362": ["Glycosphingolipid metabolism", "The activation of arylsulfatases"], "285381": ["Synthesis of diphthamide-EEF2"], "2854": ["G alpha (s) signalling events"], "285440": ["Endogenous sterols", "The canonical retinoid cycle in rods (twilight vision)"], "285521": ["TP53 Regulates Metabolic Genes", "Respiratory electron transport"], "285601": ["G alpha (s) signalling events"], "285643": ["MHC class II antigen presentation", "Recycling pathway of L1", "Recycling pathway of L1", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "285659": ["Olfactory Signaling Pathway"], "285676": ["Generic Transcription Pathway"], "285704": ["Netrin-1 signaling"], "285755": ["mRNA Splicing - Major Pathway"], "285852": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "2859": ["Class A/1 (Rhodopsin-like receptors)"], "285971": ["Generic Transcription Pathway"], "285973": ["Macroautophagy"], "286": ["Interaction between L1 and Ankyrins", "Interaction between L1 and Ankyrins", "NrCAM interactions", "CHL1 interactions", "Neurofascin interactions", "Neurofascin interactions", "COPI-mediated anterograde transport"], "286053": ["SUMOylation of DNA damage response and repair proteins"], "286075": ["Generic Transcription Pathway"], "286097": ["Mitochondrial calcium ion transport", "Processing of SMDT1"], "2861": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "286133": ["Scavenging by Class A Receptors"], "2862": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "286205": ["RHO GTPases Activate Formins"], "286256": ["Transport of fatty acids"], "2863": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (q) signalling events", "G alpha (s) signalling events"], "286362": ["Olfactory Signaling Pathway"], "286365": ["Olfactory Signaling Pathway"], "2864": ["Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)", "G alpha (q) signalling events", "Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "Free fatty acid receptors"], "286410": ["Ion transport by P-type ATPases"], "286451": ["Golgi Associated Vesicle Biogenesis"], "2865": ["G alpha (q) signalling events", "Free fatty acid receptors"], "2867": ["G alpha (q) signalling events", "Free fatty acid receptors"], "286749": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "2868": ["Inactivation, recovery and regulation of the phototransduction cascade"], "286826": ["Transcription of E2F targets under negative control by DREAM complex", "Transcription of E2F targets under negative control by DREAM complex", "Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1", "G0 and Early G1", "Polo-like kinase mediated events", "Activation of E2F1 target genes at G1/S", "Cyclin E associated events during G1/S transition ", "Cyclin A:Cdk2-associated events at S phase entry"], "286887": ["Keratinization", "Formation of the cornified envelope"], "2869": ["G alpha (q) signalling events", "G alpha (s) signalling events"], "287": ["Interaction between L1 and Ankyrins", "Interaction between L1 and Ankyrins", "COPI-mediated anterograde transport"], "2870": ["G alpha (s) signalling events"], "2873": ["DNA Damage Recognition in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Cargo recognition for clathrin-mediated endocytosis", "Neddylation"], "2874": ["PPARA activates gene expression", "HDACs deacetylate histones", "Loss of MECP2 binding ability to the NCoR/SMRT complex", "Regulation of MECP2 expression and activity"], "2875": ["Amino acid synthesis and interconversion (transamination)"], "2876": ["Synthesis of 5-eicosatetraenoic acids", "Synthesis of 12-eicosatetraenoic acid derivatives", "Synthesis of 15-eicosatetraenoic acid derivatives", "Detoxification of Reactive Oxygen Species", "Purine catabolism"], "2877": ["Synthesis of 5-eicosatetraenoic acids", "Synthesis of 12-eicosatetraenoic acid derivatives", "Synthesis of 15-eicosatetraenoic acid derivatives", "Detoxification of Reactive Oxygen Species", "TP53 Regulates Metabolic Genes"], "2878": ["Detoxification of Reactive Oxygen Species"], "2879": ["Synthesis of 5-eicosatetraenoic acids", "Synthesis of 12-eicosatetraenoic acid derivatives", "Synthesis of 15-eicosatetraenoic acid derivatives", "Biosynthesis of D-series resolvins", "Biosynthesis of E-series 18(S)-resolvins", "Biosynthesis of aspirin-triggered D-series resolvins", "Biosynthesis of E-series 18(R)-resolvins"], "288": ["Interaction between L1 and Ankyrins", "Interaction between L1 and Ankyrins", "COPI-mediated anterograde transport"], "2880": ["Detoxification of Reactive Oxygen Species"], "2882": ["Detoxification of Reactive Oxygen Species"], "2885": ["PI3K Cascade", "SOS-mediated signalling", "SOS-mediated signalling", "Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "SHC1 events in ERBB2 signaling", "SHC1 events in ERBB4 signaling", "PIP3 activates AKT signaling", "Spry regulation of FGF signaling", "Signaling by SCF-KIT", "Regulation of KIT signaling", "Signalling to RAS", "Signalling to RAS", "GRB2 events in EGFR signaling", "GAB1 signalosome", "SHC1 events in EGFR signaling", "EGFR downregulation", "Signaling by cytosolic FGFR1 fusion mutants", "Downstream signal transduction", "GRB2 events in ERBB2 signaling", "GRB2 events in ERBB2 signaling", "PI3K events in ERBB2 signaling", "Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "Tie2 Signaling", "EGFR Transactivation by Gastrin", "Constitutive Signaling by Aberrant PI3K in Cancer", "DAP12 signaling", "SHC-related events triggered by IGF1R", "SHC-related events triggered by IGF1R", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "GRB2:SOS provides linkage to MAPK signaling for Integrins ", "NCAM signaling for neurite out-growth", "Costimulation by the CD28 family", "CD28 dependent Vav1 pathway", "Signal regulatory protein family interactions", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "Constitutive Signaling by EGFRvIII", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "PI-3K cascade:FGFR3", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "PI-3K cascade:FGFR4", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "Signaling by FGFR2 in disease", "Signaling by FGFR4 in disease", "Signaling by FGFR1 in disease", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs", "RAF/MAP kinase cascade", "Negative regulation of MET activity", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Signal attenuation", "Insulin receptor signalling cascade", "Insulin receptor signalling cascade", "MET activates RAS signaling", "MET activates PI3K/AKT signaling", "Signaling by FGFR3 fusions in cancer", "Signaling by FGFR3 point mutants in cancer", "RET signaling", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "MET activates PTPN11", "InlB-mediated entry of Listeria monocytogenes into host cell", "InlB-mediated entry of Listeria monocytogenes into host cell", "MET activates RAP1 and RAC1", "MET receptor recycling", "Interleukin-15 signaling", "Interleukin-15 signaling", "Activated NTRK2 signals through RAS", "Erythropoietin activates RAS", "Erythropoietin activates RAS", "Activated NTRK2 signals through PI3K", "Activated NTRK2 signals through FRS2 and FRS3", "Activated NTRK2 signals through FRS2 and FRS3", "Activated NTRK3 signals through RAS", "Interleukin receptor SHC signaling", "Regulation of signaling by CBL", "Regulation of signaling by CBL", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "2886": ["GRB7 events in ERBB2 signaling", "Signaling by SCF-KIT", "Downstream signal transduction", "Tie2 Signaling", "RET signaling"], "2887": ["Signaling by SCF-KIT", "IRS activation", "Signal attenuation", "Insulin receptor signalling cascade", "RET signaling"], "2888": ["Tie2 Signaling"], "2889": ["Frs2-mediated activation", "Frs2-mediated activation", "Downstream signal transduction", "MET activates RAP1 and RAC1", "Erythropoietin activates RAS", "Erythropoietin activates RAS", "Regulation of signaling by CBL"], "2890": ["COPII-mediated vesicle transport", "Activation of AMPA receptors", "Trafficking of AMPA receptors", "Trafficking of GluR2-containing AMPA receptors", "Unblocking of NMDA receptors, glutamate binding and activation", "Unblocking of NMDA receptors, glutamate binding and activation", "Cargo concentration in the ER", "Synaptic adhesion-like molecules", "Long-term potentiation"], "2891": ["Activation of AMPA receptors", "Trafficking of GluR2-containing AMPA receptors", "Unblocking of NMDA receptors, glutamate binding and activation", "Unblocking of NMDA receptors, glutamate binding and activation", "MECP2 regulates neuronal receptors and channels", "Long-term potentiation"], "2892": ["Activation of AMPA receptors", "Trafficking of AMPA receptors", "Trafficking of GluR2-containing AMPA receptors", "Unblocking of NMDA receptors, glutamate binding and activation", "Unblocking of NMDA receptors, glutamate binding and activation", "Synaptic adhesion-like molecules"], "2893": ["Activation of AMPA receptors", "Trafficking of AMPA receptors", "Trafficking of GluR2-containing AMPA receptors", "Unblocking of NMDA receptors, glutamate binding and activation", "Unblocking of NMDA receptors, glutamate binding and activation", "Synaptic adhesion-like molecules"], "28952": ["Neddylation"], "28956": ["Macroautophagy", "mTOR signalling", "mTORC1-mediated signalling", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "MAP2K and MAPK activation", "Neutrophil degranulation", "Regulation of PTEN gene transcription"], "28957": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "2896": ["Neutrophil degranulation"], "28960": ["mRNA decay by 3' to 5' exoribonuclease"], "28962": ["Stimuli-sensing channels"], "28964": ["Ephrin signaling", "Ephrin signaling", "Activation of RAC1 downstream of NMDARs"], "28965": ["Transport of fatty acids"], "2897": ["Activation of Na-permeable kainate receptors", "Activation of Ca-permeable Kainate Receptor"], "28972": ["SRP-dependent cotranslational protein targeting to membrane", "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)", "Synthesis, secretion, and deacylation of Ghrelin"], "28973": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "28976": ["Complex I biogenesis"], "28977": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "2898": ["Activation of Na-permeable kainate receptors", "Activation of Ca-permeable Kainate Receptor"], "28981": ["Intraflagellar transport", "Intraflagellar transport"], "28982": ["Iron uptake and transport"], "28984": ["TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "28987": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "28988": ["Caspase-mediated cleavage of cytoskeletal proteins", "Neurexins and neuroligins", "Neutrophil degranulation"], "2899": ["Activation of Ca-permeable Kainate Receptor", "Presynaptic function of Kainate receptors"], "28991": ["Neddylation"], "28996": ["YAP1- and WWTR1 (TAZ)-stimulated gene expression", "SUMOylation of transcription cofactors", "Physiological factors", "Regulation of TP53 Activity through Phosphorylation", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Regulation of MECP2 expression and activity"], "28998": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "28999": ["BMAL1:CLOCK,NPAS2 activates circadian gene expression"], "29": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "290": ["Metabolism of Angiotensinogen to Angiotensins", "Neutrophil degranulation"], "2900": ["Activation of Ca-permeable Kainate Receptor"], "2901": ["Activation of Ca-permeable Kainate Receptor"], "2902": ["EPHB-mediated forward signaling", "EPHB-mediated forward signaling", "Unblocking of NMDA receptors, glutamate binding and activation", "Unblocking of NMDA receptors, glutamate binding and activation", "Ras activation upon Ca2+ influx through NMDA receptor", "RAF/MAP kinase cascade", "Neurexins and neuroligins", "Synaptic adhesion-like molecules", "Negative regulation of NMDA receptor-mediated neuronal transmission", "Long-term potentiation"], "29028": ["TFAP2 (AP-2) family regulates transcription of growth factors and their receptors"], "2903": ["Unblocking of NMDA receptors, glutamate binding and activation", "Unblocking of NMDA receptors, glutamate binding and activation", "Neurexins and neuroligins", "Synaptic adhesion-like molecules", "MECP2 regulates neuronal receptors and channels", "Negative regulation of NMDA receptor-mediated neuronal transmission", "Long-term potentiation"], "2904": ["EPHB-mediated forward signaling", "EPHB-mediated forward signaling", "Unblocking of NMDA receptors, glutamate binding and activation", "Unblocking of NMDA receptors, glutamate binding and activation", "Ras activation upon Ca2+ influx through NMDA receptor", "RAF/MAP kinase cascade", "Neurexins and neuroligins", "Synaptic adhesion-like molecules", "MECP2 regulates neuronal receptors and channels", "Activated NTRK2 signals through FYN", "Negative regulation of NMDA receptor-mediated neuronal transmission", "Long-term potentiation"], "2905": ["Unblocking of NMDA receptors, glutamate binding and activation", "Unblocking of NMDA receptors, glutamate binding and activation", "Neurexins and neuroligins", "Synaptic adhesion-like molecules", "Negative regulation of NMDA receptor-mediated neuronal transmission", "Long-term potentiation"], "2906": ["Unblocking of NMDA receptors, glutamate binding and activation", "Unblocking of NMDA receptors, glutamate binding and activation", "Ras activation upon Ca2+ influx through NMDA receptor", "RAF/MAP kinase cascade", "Neurexins and neuroligins", "Synaptic adhesion-like molecules", "Negative regulation of NMDA receptor-mediated neuronal transmission", "Long-term potentiation"], "29071": ["Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)", "O-linked glycosylation of mucins"], "29072": ["PKMTs methylate histone lysines"], "29074": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "29078": ["Complex I biogenesis"], "29079": ["PPARA activates gene expression", "Generic Transcription Pathway", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "2908": ["HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Nuclear Receptor transcription pathway", "Circadian Clock", "SUMOylation of intracellular receptors", "PTK6 Expression", "Regulation of RUNX2 expression and activity", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes"], "29080": ["Surfactant metabolism", "Defective pro-SFTPB causes pulmonary surfactant metabolism dysfunction 1 (SMDP1) and respiratory distress syndrome (RDS)"], "29082": ["Budding and maturation of HIV virion", "Macroautophagy", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "29086": ["Metalloprotease DUBs", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "G2/M DNA damage checkpoint"], "29088": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "29089": ["Fanconi Anemia Pathway", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes"], "2909": ["Rho GTPase cycle", "Sema4D mediated inhibition of cell attachment and migration", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases"], "29090": ["Mitochondrial protein import"], "29093": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "29095": ["Sphingolipid de novo biosynthesis"], "29098": ["Phase 0 - rapid depolarisation"], "29099": ["Neutrophil degranulation", "Neddylation"], "291": ["Mitochondrial protein import", "Mitochondrial protein import", "Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization", "Regulation of insulin secretion"], "29101": ["RNA polymerase II transcribes snRNA genes"], "29102": ["MicroRNA (miRNA) biogenesis"], "29104": ["Methylation", "Eukaryotic Translation Termination"], "29106": ["Platelet degranulation ", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "29107": ["Transport of Mature mRNA derived from an Intron-Containing Transcript"], "29108": ["CLEC7A/inflammasome pathway", "Neutrophil degranulation", "The NLRP3 inflammasome", "The AIM2 inflammasome"], "2911": ["G alpha (q) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)", "Neurexins and neuroligins", "Neurexins and neuroligins"], "29110": ["IRF3 mediated activation of type 1 IFN", "IRF3 mediated activation of type 1 IFN", "Regulation of innate immune responses to cytosolic DNA", "STAT6-mediated induction of chemokines", "IRF3-mediated induction of type I IFN", "Interleukin-37 signaling", "TICAM1-dependent activation of IRF3/IRF7", "TRAF3-dependent IRF activation pathway", "TRAF6 mediated IRF7 activation", "Negative regulators of DDX58/IFIH1 signaling", "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon"], "29115": ["NoRC negatively regulates rRNA expression"], "29116": ["VLDLR internalisation and degradation", "Antigen processing: Ubiquitination & Proteasome degradation"], "29117": ["Regulation of TP53 Activity through Acetylation"], "2912": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "29121": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "29126": ["PD-1 signaling"], "29127": ["Rho GTPase cycle", "MHC class II antigen presentation", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "29128": ["DNA methylation"], "2913": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "2914": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "2915": ["G alpha (q) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)", "Neurexins and neuroligins", "Neurexins and neuroligins"], "2916": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "2917": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "2918": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "2919": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events", "Interleukin-10 signaling", "Neutrophil degranulation"], "292": ["Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization", "Regulation of insulin secretion"], "2920": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events", "Interleukin-10 signaling"], "2921": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "2922": ["Peptide ligand-binding receptors", "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "G alpha (q) signalling events"], "2923": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Calnexin/calreticulin cycle", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "2925": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "2926": ["Viral mRNA Translation"], "293": ["Mitochondrial protein import", "Mitochondrial protein import", "Influenza Virus Induced Apoptosis", "Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization", "Regulation of insulin secretion"], "2931": ["AKT phosphorylates targets in the cytosol", "XBP1(S) activates chaperone genes", "Constitutive Signaling by AKT1 E17K in Cancer"], "2932": ["Degradation of beta-catenin by the destruction complex", "Beta-catenin phosphorylation cascade", "AKT phosphorylates targets in the cytosol", "Regulation of HSF1-mediated heat shock response", "CRMPs in Sema3A signaling", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "B-WICH complex positively regulates rRNA expression", "Misspliced GSK3beta mutants stabilize beta-catenin", "S33 mutants of beta-catenin aren't phosphorylated", "S37 mutants of beta-catenin aren't phosphorylated", "S45 mutants of beta-catenin aren't phosphorylated", "T41 mutants of beta-catenin aren't phosphorylated", "APC truncation mutants have impaired AXIN binding", "AXIN missense mutants destabilize the destruction complex", "Truncations of AMER1 destabilize the destruction complex", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Constitutive Signaling by AKT1 E17K in Cancer", "Ubiquitin-dependent degradation of Cyclin D1", "Regulation of RUNX2 expression and activity"], "2934": ["Caspase-mediated cleavage of cytoskeletal proteins", "Neutrophil degranulation", "Amyloid fiber formation"], "2935": ["Eukaryotic Translation Termination", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "2936": ["Metabolism of ingested H2SeO4 and H2SeO3 into H2Se", "Detoxification of Reactive Oxygen Species", "Interconversion of nucleotide di- and triphosphates", "TP53 Regulates Metabolic Genes"], "2937": ["Glutathione synthesis and recycling", "Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)"], "2938": ["Glutathione conjugation"], "2939": ["Glutathione conjugation", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "2940": ["Glutathione conjugation"], "2941": ["Glutathione conjugation"], "2944": ["Glutathione conjugation"], "2946": ["Glutathione conjugation"], "2947": ["Glutathione conjugation"], "2948": ["Glutathione conjugation", "Biosynthesis of maresin conjugates in tissue regeneration (MCTR)"], "2949": ["Glutathione conjugation"], "2950": ["Glutathione conjugation", "Detoxification of Reactive Oxygen Species", "Neutrophil degranulation"], "2952": ["Glutathione conjugation"], "2953": ["Glutathione conjugation"], "2954": ["Glutathione conjugation", "Regulation of pyruvate dehydrogenase (PDH) complex", "Phenylalanine and tyrosine catabolism"], "2956": ["Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "Defective Mismatch Repair Associated With MSH2", "Defective Mismatch Repair Associated With MSH6"], "2957": ["HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "RNA Polymerase II Pre-transcription Events", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "Estrogen-dependent gene expression"], "2958": ["HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "RNA Polymerase II Pre-transcription Events", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "Estrogen-dependent gene expression"], "2959": ["HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "RNA Polymerase II Pre-transcription Events", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "2960": ["HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "RNA Polymerase II Pre-transcription Events", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "2961": ["HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "RNA Polymerase II Pre-transcription Events", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "2962": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Abortive elongation of HIV-1 transcript in the absence of Tat", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "Viral Messenger RNA Synthesis", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE", "Signaling by FGFR2 IIIa TM", "Estrogen-dependent gene expression"], "2963": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Abortive elongation of HIV-1 transcript in the absence of Tat", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "Viral Messenger RNA Synthesis", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE", "Signaling by FGFR2 IIIa TM", "Estrogen-dependent gene expression"], "2965": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Tat-mediated elongation of the HIV-1 transcript", "NoRC negatively regulates rRNA expression", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "mRNA Capping", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase I Transcription Termination", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE"], "2966": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Tat-mediated elongation of the HIV-1 transcript", "NoRC negatively regulates rRNA expression", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "mRNA Capping", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase I Transcription Termination", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE"], "2967": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Tat-mediated elongation of the HIV-1 transcript", "NoRC negatively regulates rRNA expression", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "mRNA Capping", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase I Transcription Termination", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE"], "2968": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Tat-mediated elongation of the HIV-1 transcript", "NoRC negatively regulates rRNA expression", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "mRNA Capping", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase I Transcription Termination", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE"], "2971": ["RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 1 Promoter"], "2972": ["RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter"], "29748232": ["Toxicity of botulinum toxin type B (BoNT/B)", "Toxicity of botulinum toxin type A (BoNT/A)", "Toxicity of botulinum toxin type E (BoNT/E)"], "2975": ["RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter"], "2976": ["RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter"], "29760": ["Regulation of signaling by CBL", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "29761": ["Ub-specific processing proteases"], "29763": ["Clathrin-mediated endocytosis"], "29765": ["Striated Muscle Contraction"], "29766": ["Striated Muscle Contraction"], "29767": ["Striated Muscle Contraction"], "2977": ["Nitric oxide stimulates guanylate cyclase", "Smooth Muscle Contraction"], "2978": ["Inactivation, recovery and regulation of the phototransduction cascade"], "29780": ["Cell-extracellular matrix interactions", "Regulation of cytoskeletal remodeling and cell spreading by IPP complex components"], "29781": ["Condensation of Prophase Chromosomes"], "29785": ["Miscellaneous substrates", "Xenobiotics", "CYP2E1 reactions"], "29789": ["Platelet degranulation "], "2979": ["Inactivation, recovery and regulation of the phototransduction cascade"], "29796": ["Respiratory electron transport"], "2980": ["Digestion"], "29801": ["HDL assembly"], "29802": ["Cell surface interactions at the vascular wall"], "2981": ["Digestion"], "2982": ["Nitric oxide stimulates guanylate cyclase", "Smooth Muscle Contraction"], "2983": ["Nitric oxide stimulates guanylate cyclase", "Smooth Muscle Contraction"], "2984": ["Digestion", "Intestinal infectious diseases"], "29841": ["PPARA activates gene expression"], "29843": ["SUMO is proteolytically processed"], "29844": ["UCH proteinases", "DNA Damage Recognition in GG-NER"], "29850": ["TRP channels"], "29851": ["PIP3 activates AKT signaling", "Constitutive Signaling by Aberrant PI3K in Cancer", "Costimulation by the CD28 family", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "29855": ["Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "2986": ["Inactivation, recovery and regulation of the phototransduction cascade"], "2987": ["Abacavir metabolism", "Interconversion of nucleotide di- and triphosphates"], "29880": ["Synthesis of dolichyl-phosphate-glucose"], "29881": ["Intestinal lipid absorption", "Intestinal lipid absorption"], "29882": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6", "Antigen processing: Ubiquitination & Proteasome degradation"], "29883": ["Deadenylation of mRNA", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "29893": ["Meiotic recombination"], "29894": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA Derived from an Intronless Transcript", "tRNA processing in the nucleus", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "29895": ["Smooth Muscle Contraction"], "29899": ["G alpha (i) signalling events"], "2990": ["HS-GAG degradation", "Hyaluronan uptake and degradation", "MPS VII - Sly syndrome", "Neutrophil degranulation"], "29904": ["mTORC1-mediated signalling"], "29906": ["Sialic acid metabolism"], "29914": ["Metabolism of vitamin K"], "2992": ["Glycogen synthesis", "Myoclonic epilepsy of Lafora", "Glycogen storage disease type XV (GYG1)", "Glycogen storage disease type 0 (muscle GYS1)", "Glycogen storage disease type II (GAA)", "Neutrophil degranulation", "Glycogen breakdown (glycogenolysis)", "Glycogen breakdown (glycogenolysis)"], "29920": ["Amino acid synthesis and interconversion (transamination)"], "29922": ["Recruitment of mitotic centrosome proteins and complexes", "Recruitment of NuMA to mitotic centrosomes"], "29923": ["Lipid particle organization"], "29924": ["EGFR downregulation", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "29925": ["Synthesis of GDP-mannose"], "29926": ["Synthesis of GDP-mannose"], "29927": ["ER-Phagosome pathway", "SRP-dependent cotranslational protein targeting to membrane", "XBP1(S) activates chaperone genes"], "29928": ["Mitochondrial protein import", "Mitochondrial protein import"], "29929": ["Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "Defective ALG6 causes ALG6-CDG (CDG-1c)"], "2993": ["Cell surface interactions at the vascular wall"], "29933": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (q) signalling events"], "29935": ["Activation of the pre-replicative complex"], "2994": ["Cell surface interactions at the vascular wall"], "29940": ["Dermatan sulfate biosynthesis"], "29941": ["RHO GTPases activate PKNs"], "29943": ["Chromatin modifying enzymes"], "29945": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6", "Antigen processing: Ubiquitination & Proteasome degradation"], "29947": ["DNA methylation"], "29949": ["Interleukin-20 family signaling"], "2995": ["Cell surface interactions at the vascular wall"], "29952": ["Neutrophil degranulation"], "29954": ["Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2", "O-linked glycosylation"], "29956": ["Sphingolipid de novo biosynthesis"], "29958": ["Choline catabolism"], "29959": ["Nuclear Receptor transcription pathway"], "29960": ["rRNA modification in the mitochondrion"], "29967": ["Retinoid metabolism and transport"], "29968": ["Serine biosynthesis"], "2997": ["Glycogen synthesis", "Myoclonic epilepsy of Lafora", "Glycogen storage disease type XV (GYG1)", "Glycogen storage disease type 0 (muscle GYS1)"], "29974": ["mRNA Editing: C to U Conversion", "Formation of the Editosome"], "29978": ["Cargo recognition for clathrin-mediated endocytosis"], "29979": ["Cargo recognition for clathrin-mediated endocytosis"], "2998": ["Glycogen synthesis", "Glycogen storage disease type 0 (liver GYS2)", "Glycogen storage disease type IV (GBE1)"], "29982": ["Nuclear Receptor transcription pathway"], "29984": ["Rho GTPase cycle", "RHO GTPases Activate Formins"], "29985": ["Zinc influx into cells by the SLC39 gene family"], "29986": ["Zinc influx into cells by the SLC39 gene family"], "29988": ["Cellular hexose transport", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "2999": ["Metabolism of Angiotensinogen to Angiotensins", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "29990": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "29992": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "29993": ["Clathrin-mediated endocytosis"], "29995": ["Surfactant metabolism"], "30": ["alpha-linolenic acid (ALA) metabolism", "Beta-oxidation of very long chain fatty acids", "Neutrophil degranulation", "Peroxisomal protein import", "Peroxisomal protein import", "TYSND1 cleaves peroxisomal proteins"], "3000": ["Inactivation, recovery and regulation of the phototransduction cascade"], "30001": ["Insulin processing", "Detoxification of Reactive Oxygen Species"], "30008": ["Molecules associated with elastic fibres", "Molecules associated with elastic fibres"], "30011": ["EGFR downregulation", "Negative regulation of MET activity", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "Reelin signalling pathway", "InlB-mediated entry of Listeria monocytogenes into host cell", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "3002": ["NOTCH2 intracellular domain regulates transcription", "Activation, myristolyation of BID and translocation to mitochondria"], "3004": ["Alternative complement activation"], "3005": ["Activation of DNA fragmentation factor", "Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "3006": ["Activation of DNA fragmentation factor", "Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "30061": ["Metal ion SLC transporters", "Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages)", "Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum)", "Iron uptake and transport"], "3007": ["Activation of DNA fragmentation factor", "Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "3008": ["Activation of DNA fragmentation factor", "Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "3009": ["Activation of DNA fragmentation factor", "Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "301": ["G alpha (q) signalling events", "G alpha (i) signalling events", "Formyl peptide receptors bind formyl peptides and many other ligands", "Smooth Muscle Contraction", "Interleukin-4 and Interleukin-13 signaling"], "3012": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "HATs acetylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "UCH proteinases", "Ub-specific processing proteases", "Metalloprotease DUBs", "Deposition of new CENPA-containing nucleosomes at the centromere", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "3013": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "HATs acetylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "UCH proteinases", "Ub-specific processing proteases", "Metalloprotease DUBs", "Deposition of new CENPA-containing nucleosomes at the centromere", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "3014": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "3015": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Deposition of new CENPA-containing nucleosomes at the centromere", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "3017": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "HATs acetylate histones", "HATs acetylate histones", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Ub-specific processing proteases", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "E3 ubiquitin ligases ubiquitinate target proteins", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "3018": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "HATs acetylate histones", "HATs acetylate histones", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Ub-specific processing proteases", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "E3 ubiquitin ligases ubiquitinate target proteins", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "302": ["Smooth Muscle Contraction", "Neutrophil degranulation", "Dissolution of Fibrin Clot", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "3020": ["Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation", "Factors involved in megakaryocyte development and platelet production"], "3021": ["Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation", "Factors involved in megakaryocyte development and platelet production"], "3024": ["Activation of DNA fragmentation factor", "Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "3028": ["tRNA processing in the mitochondrion", "tRNA modification in the mitochondrion", "Branched-chain amino acid catabolism", "rRNA processing in the mitochondrion"], "3029": ["Pyruvate metabolism"], "3030": ["Acyl chain remodeling of CL", "Beta oxidation of myristoyl-CoA to lauroyl-CoA", "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids", "Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "Beta oxidation of hexanoyl-CoA to butanoyl-CoA"], "3032": ["Acyl chain remodeling of CL", "Beta oxidation of myristoyl-CoA to lauroyl-CoA", "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids", "Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "Beta oxidation of hexanoyl-CoA to butanoyl-CoA"], "3033": ["Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "Beta oxidation of butanoyl-CoA to acetyl-CoA"], "3034": ["Histidine catabolism"], "3035": ["Cytosolic tRNA aminoacylation"], "3036": ["Hyaluronan biosynthesis and export"], "3037": ["Hyaluronan biosynthesis and export"], "3038": ["Hyaluronan biosynthesis and export"], "3039": ["Erythrocytes take up carbon dioxide and release oxygen", "Erythrocytes take up oxygen and release carbon dioxide", "Scavenging of heme from plasma"], "3040": ["Erythrocytes take up carbon dioxide and release oxygen", "Erythrocytes take up oxygen and release carbon dioxide", "Scavenging of heme from plasma"], "3043": ["Erythrocytes take up carbon dioxide and release oxygen", "Erythrocytes take up oxygen and release carbon dioxide", "Scavenging of heme from plasma", "Neutrophil degranulation", "Factors involved in megakaryocyte development and platelet production"], "3045": ["Factors involved in megakaryocyte development and platelet production"], "3046": ["Factors involved in megakaryocyte development and platelet production"], "3047": ["Factors involved in megakaryocyte development and platelet production"], "3048": ["Factors involved in megakaryocyte development and platelet production"], "3053": ["Intrinsic Pathway of Fibrin Clot Formation", "Common Pathway of Fibrin Clot Formation", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "3054": ["Transcriptional activation of mitochondrial biogenesis", "HATs acetylate histones", "UCH proteinases"], "3055": ["Nef and signal transduction", "FCGR activation", "Regulation of signaling by CBL", "Regulation of signaling by CBL"], "3060": ["Orexin and neuropeptides FF and QRFP bind to their respective receptors", "G alpha (q) signalling events"], "3061": ["Orexin and neuropeptides FF and QRFP bind to their respective receptors", "G alpha (q) signalling events"], "3062": ["Orexin and neuropeptides FF and QRFP bind to their respective receptors", "G alpha (q) signalling events"], "3064": ["Regulation of MECP2 expression and activity"], "3065": ["Transcription of E2F targets under negative control by DREAM complex", "Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1", "G0 and Early G1", "p75NTR negatively regulates cell cycle via SC1", "Formation of the beta-catenin:TCF transactivating complex", "NOTCH1 Intracellular Domain Regulates Transcription", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "HDACs deacetylate histones", "Deactivation of the beta-catenin transactivating complex", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "SUMOylation of chromatin organization proteins", "Repression of WNT target genes", "Repression of WNT target genes", "Activation of E2F1 target genes at G1/S", "Regulation of TP53 Activity through Acetylation", "RNA Polymerase I Transcription Initiation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription", "Estrogen-dependent gene expression", "Loss of MECP2 binding ability to 5mC-DNA", "Regulation of MECP2 expression and activity", "MECP2 regulates neuronal receptors and channels", "MECP2 regulates transcription of neuronal ligands", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "Factors involved in megakaryocyte development and platelet production"], "3066": ["p75NTR negatively regulates cell cycle via SC1", "NOTCH1 Intracellular Domain Regulates Transcription", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "HDACs deacetylate histones", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "SUMOylation of chromatin organization proteins", "Regulation of TP53 Activity through Acetylation", "RNA Polymerase I Transcription Initiation", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription", "Regulation of MECP2 expression and activity", "MECP2 regulates neuronal receptors and channels", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "Factors involved in megakaryocyte development and platelet production"], "3067": ["Histidine catabolism"], "3068": ["XBP1(S) activates chaperone genes"], "3069": ["HDL clearance"], "3071": ["Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs", "Neutrophil degranulation"], "3073": ["Glycosphingolipid metabolism", "Keratan sulfate degradation", "CS/DS degradation", "Hyaluronan uptake and degradation", "Defective HEXA causes GM2G1"], "3074": ["Glycosphingolipid metabolism", "Keratan sulfate degradation", "CS/DS degradation", "Hyaluronan uptake and degradation", "Defective HEXB causes GM2G2", "Neutrophil degranulation"], "3075": ["Regulation of Complement cascade"], "3077": ["Transferrin endocytosis and recycling"], "3078": ["Regulation of Complement cascade"], "308": ["Platelet degranulation "], "3080": ["Regulation of Complement cascade"], "3081": ["Phenylalanine and tyrosine catabolism"], "30814": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PS", "Acyl chain remodelling of PE", "Acyl chain remodelling of PI", "Acyl chain remodelling of PG", "Synthesis of PA"], "30815": ["Sialic acid metabolism"], "30817": ["Class B/2 (Secretin family receptors)"], "30818": ["Phase 1 - inactivation of fast Na+ channels"], "30819": ["Phase 1 - inactivation of fast Na+ channels"], "3082": ["Platelet degranulation ", "PIP3 activates AKT signaling", "Interleukin-7 signaling", "Constitutive Signaling by Aberrant PI3K in Cancer", "RAF/MAP kinase cascade", "Interleukin-4 and Interleukin-13 signaling", "MET Receptor Activation", "Negative regulation of MET activity", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "MET activates RAS signaling", "MET activates PI3K/AKT signaling", "MET activates PTPN11", "MET activates PTK2 signaling", "MET interacts with TNS proteins", "MET activates RAP1 and RAC1", "MET receptor recycling", "MET activates STAT3"], "30820": ["Phase 1 - inactivation of fast Na+ channels"], "30827": ["XBP1(S) activates chaperone genes"], "3083": ["MET Receptor Activation"], "30832": ["Generic Transcription Pathway"], "30833": ["Pyrimidine catabolism", "Purine catabolism"], "30834": ["NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase I Transcription Termination"], "30835": ["CD209 (DC-SIGN) signaling", "Butyrophilin (BTN) family interactions"], "3084": ["Signaling by ERBB2", "Signaling by ERBB4", "SHC1 events in ERBB2 signaling", "SHC1 events in ERBB2 signaling", "PI3K events in ERBB4 signaling", "SHC1 events in ERBB4 signaling", "Nuclear signaling by ERBB4", "PIP3 activates AKT signaling", "GRB7 events in ERBB2 signaling", "Downregulation of ERBB2:ERBB3 signaling", "GRB2 events in ERBB2 signaling", "PI3K events in ERBB2 signaling", "Constitutive Signaling by Aberrant PI3K in Cancer", "RAF/MAP kinase cascade", "ERBB2 Regulates Cell Motility", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "ERBB2 Activates PTK6 Signaling", "Downregulation of ERBB2 signaling", "Long-term potentiation"], "30845": ["Factors involved in megakaryocyte development and platelet production"], "30846": ["Factors involved in megakaryocyte development and platelet production"], "30849": ["PI3K Cascade", "Macroautophagy", "Synthesis of PIPs at the Golgi membrane", "Synthesis of PIPs at the early endosome membrane", "Synthesis of PIPs at the late endosome membrane", "Toll Like Receptor 9 (TLR9) Cascade", "RHO GTPases Activate NADPH Oxidases"], "30851": ["RHO GTPases Activate Rhotekin and Rhophilins"], "309": ["Smooth Muscle Contraction"], "3090": ["SUMOylation of transcription factors"], "3091": ["Regulation of gene expression by Hypoxia-inducible Factor", "Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "NOTCH1 Intracellular Domain Regulates Transcription", "Circadian Clock", "Ub-specific processing proteases", "Interleukin-4 and Interleukin-13 signaling", "PTK6 Expression", "PTK6 promotes HIF1A stabilization", "Neddylation"], "3092": ["Clathrin-mediated endocytosis"], "3093": ["Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Negative regulators of DDX58/IFIH1 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "30968": ["Processing of SMDT1"], "3098": ["Defective HK1 causes hexokinase deficiency (HK deficiency)", "Glycolysis"], "3099": ["Glycolysis"], "31": ["ChREBP activates metabolic gene expression", "Biotin transport and metabolism", "Import of palmitoyl-CoA into the mitochondrial matrix", "Activation of gene expression by SREBF (SREBP)", "Defective HLCS causes multiple carboxylase deficiency", "Fatty acyl-CoA biosynthesis"], "3101": ["Neutrophil degranulation", "Glycolysis"], "3105": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "E3 ubiquitin ligases ubiquitinate target proteins", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "3106": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "3107": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "3109": ["MHC class II antigen presentation"], "3111": ["MHC class II antigen presentation"], "3112": ["MHC class II antigen presentation"], "3113": ["Downstream TCR signaling", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "MHC class II antigen presentation", "PD-1 signaling", "Interferon gamma signaling"], "3115": ["Downstream TCR signaling", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "MHC class II antigen presentation", "PD-1 signaling", "Interferon gamma signaling"], "3117": ["Downstream TCR signaling", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "MHC class II antigen presentation", "PD-1 signaling", "Interferon gamma signaling"], "3118": ["Downstream TCR signaling", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "MHC class II antigen presentation", "PD-1 signaling", "Interferon gamma signaling"], "3119": ["Downstream TCR signaling", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "MHC class II antigen presentation", "PD-1 signaling", "Interferon gamma signaling"], "3120": ["Downstream TCR signaling", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "MHC class II antigen presentation", "PD-1 signaling", "Interferon gamma signaling"], "3122": ["Downstream TCR signaling", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "MHC class II antigen presentation", "PD-1 signaling", "Interferon gamma signaling"], "3123": ["Downstream TCR signaling", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "MHC class II antigen presentation", "PD-1 signaling", "Interferon gamma signaling"], "3125": ["Downstream TCR signaling", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "MHC class II antigen presentation", "PD-1 signaling", "Interferon gamma signaling"], "3126": ["Downstream TCR signaling", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "MHC class II antigen presentation", "PD-1 signaling", "Interferon gamma signaling"], "3127": ["Downstream TCR signaling", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "MHC class II antigen presentation", "PD-1 signaling", "Interferon gamma signaling"], "3133": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "DAP12 interactions", "DAP12 signaling", "DAP12 signaling", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "3134": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "3135": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "314": ["Phase I - Functionalization of compounds"], "3141": ["Biotin transport and metabolism", "Defective HLCS causes multiple carboxylase deficiency"], "3145": ["Heme biosynthesis"], "3146": ["Activation of DNA fragmentation factor", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "Regulation of TLR by endogenous ligand", "Neutrophil degranulation", "Advanced glycosylation endproduct receptor signaling", "Advanced glycosylation endproduct receptor signaling", "TRAF6 mediated NF-kB activation"], "3148": ["Activation of DNA fragmentation factor"], "3150": ["Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER"], "3155": ["Synthesis of Ketone Bodies", "Peroxisomal protein import", "Peroxisomal protein import"], "3156": ["Cholesterol biosynthesis", "PPARA activates gene expression", "Activation of gene expression by SREBF (SREBP)"], "3157": ["Cholesterol biosynthesis", "PPARA activates gene expression", "Activation of gene expression by SREBF (SREBP)"], "3158": ["PPARA activates gene expression", "Synthesis of Ketone Bodies"], "3159": ["Integration of provirus", "2-LTR circle formation", "Integration of viral DNA into host genomic DNA", "Autointegration results in viral DNA circles", "APOBEC3G mediated resistance to HIV-1 infection", "Vpr-mediated nuclear import of PICs", "Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "316": ["Vitamins B6 activation to pyridoxal phosphate"], "3161": ["Hyaluronan uptake and degradation", "AURKA Activation by TPX2"], "3162": ["Heme degradation", "Interleukin-4 and Interleukin-13 signaling", "Iron uptake and transport"], "3163": ["Heme degradation", "Neutrophil degranulation", "Iron uptake and transport"], "3164": ["AKT phosphorylates targets in the nucleus", "Nuclear Receptor transcription pathway", "Constitutive Signaling by AKT1 E17K in Cancer"], "3169": ["Estrogen-dependent gene expression"], "317": ["Formation of apoptosome", "Activation of caspases through apoptosome-mediated cleavage", "SMAC (DIABLO) binds to IAPs ", "SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ", "Neutrophil degranulation", "TP53 Regulates Transcription of Caspase Activators and Caspases", "Transcriptional Regulation by E2F6", "Regulation of the apoptosome activity", "Regulation of the apoptosome activity"], "3170": ["Regulation of gene expression in beta cells"], "3171": ["Regulation of gene expression in beta cells"], "3172": ["Regulation of gene expression in beta cells", "Nuclear Receptor transcription pathway"], "3174": ["Regulation of gene expression in beta cells", "Nuclear Receptor transcription pathway"], "3175": ["Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "Regulation of gene expression in early pancreatic precursor cells"], "3176": ["Metabolism of ingested SeMet, Sec, MeSec into H2Se", "Histidine catabolism"], "317649": ["ISG15 antiviral mechanism"], "3177": ["Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"], "317772": ["HDACs deacetylate histones", "HATs acetylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "UCH proteinases", "Ub-specific processing proteases", "Metalloprotease DUBs"], "3178": ["FGFR2 alternative splicing", "mRNA Splicing - Major Pathway", "Processing of Capped Intron-Containing Pre-mRNA"], "318": ["Detoxification of Reactive Oxygen Species"], "3181": ["mRNA Splicing - Major Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "3183": ["SUMOylation of RNA binding proteins", "mRNA Splicing - Major Pathway", "Processing of Capped Intron-Containing Pre-mRNA"], "3184": ["AUF1 (hnRNP D0) binds and destabilizes mRNA", "mRNA Splicing - Major Pathway", "Processing of Capped Intron-Containing Pre-mRNA"], "3185": ["FGFR2 alternative splicing", "mRNA Splicing - Major Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "3187": ["FGFR2 alternative splicing", "mRNA Splicing - Major Pathway", "Processing of Capped Intron-Containing Pre-mRNA"], "3188": ["mRNA Splicing - Major Pathway", "Processing of Capped Intron-Containing Pre-mRNA"], "319": ["LDL remodeling"], "3190": ["SUMOylation of RNA binding proteins", "mRNA Splicing - Major Pathway", "Processing of Capped Intron-Containing Pre-mRNA"], "3191": ["mRNA Splicing - Major Pathway", "Processing of Capped Intron-Containing Pre-mRNA"], "319100": ["Amine ligand-binding receptors", "G alpha (s) signalling events"], "319101": ["Keratinization", "Formation of the cornified envelope"], "3192": ["mRNA Splicing - Major Pathway", "Processing of Capped Intron-Containing Pre-mRNA"], "3198": ["Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "3199": ["Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Regulation of expression of SLITs and ROBOs"], "32": ["ChREBP activates metabolic gene expression", "Biotin transport and metabolism", "Import of palmitoyl-CoA into the mitochondrial matrix", "Activation of gene expression by SREBF (SREBP)"], "320": ["Dopamine Neurotransmitter Release Cycle", "Neurexins and neuroligins"], "3200": ["Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "3201": ["Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "321": ["Neurexins and neuroligins"], "3211": ["Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "3212": ["Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "3213": ["Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "3214": ["Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "322": ["Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"], "3221": ["Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "3231": ["Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "3232": ["Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "3233": ["Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "324": ["Apoptotic cleavage of cellular proteins", "Degradation of beta-catenin by the destruction complex", "Beta-catenin phosphorylation cascade", "Deactivation of the beta-catenin transactivating complex", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Misspliced GSK3beta mutants stabilize beta-catenin", "S33 mutants of beta-catenin aren't phosphorylated", "S37 mutants of beta-catenin aren't phosphorylated", "S45 mutants of beta-catenin aren't phosphorylated", "T41 mutants of beta-catenin aren't phosphorylated", "APC truncation mutants are not K63 polyubiquitinated", "APC truncation mutants have impaired AXIN binding", "AXIN missense mutants destabilize the destruction complex", "Truncations of AMER1 destabilize the destruction complex", "Ovarian tumor domain proteases"], "3240": ["Scavenging of heme from plasma", "Neutrophil degranulation"], "3242": ["Phenylalanine and tyrosine catabolism"], "3248": ["Synthesis of Lipoxins (LX)", "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "Biosynthesis of D-series resolvins", "Biosynthesis of E-series 18(S)-resolvins"], "3249": ["MET Receptor Activation", "Signaling by MST1"], "325": ["Amyloid fiber formation"], "3250": ["Scavenging of heme from plasma"], "3251": ["Purine salvage"], "3257": ["RAB GEFs exchange GTP for GDP on RABs"], "3263": ["Scavenging of heme from plasma"], "3265": ["SOS-mediated signalling", "Activation of RAS in B cells", "Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "SHC1 events in ERBB2 signaling", "SHC1 events in ERBB4 signaling", "Signaling by SCF-KIT", "Signalling to RAS", "p38MAPK events", "p38MAPK events", "GRB2 events in EGFR signaling", "SHC1 events in EGFR signaling", "Downstream signal transduction", "GRB2 events in ERBB2 signaling", "GRB2 events in ERBB2 signaling", "Tie2 Signaling", "EGFR Transactivation by Gastrin", "DAP12 signaling", "SHC-related events triggered by IGF1R", "FCERI mediated MAPK activation", "NCAM signaling for neurite out-growth", "EPHB-mediated forward signaling", "Ras activation upon Ca2+ influx through NMDA receptor", "VEGFR2 mediated cell proliferation", "CD209 (DC-SIGN) signaling", "Constitutive Signaling by EGFRvIII", "SHC-mediated cascade:FGFR1", "FRS-mediated FGFR1 signaling", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "Signaling by FGFR2 in disease", "Signaling by FGFR4 in disease", "Signaling by FGFR1 in disease", "Regulation of RAS by GAPs", "RAF activation", "RAF/MAP kinase cascade", "MAP2K and MAPK activation", "Negative regulation of MAPK pathway", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "RAS signaling downstream of NF1 loss-of-function variants", "Paradoxical activation of RAF signaling by kinase inactive BRAF", "Insulin receptor signalling cascade", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "MET activates RAS signaling", "Signaling by FGFR3 fusions in cancer", "Signaling by FGFR3 point mutants in cancer", "Activated NTRK2 signals through RAS", "Erythropoietin activates RAS", "Activated NTRK2 signals through FRS2 and FRS3", "Activated NTRK3 signals through RAS"], "326624": ["Neutrophil degranulation", "RAB geranylgeranylation"], "326625": ["Cobalamin (Cbl, vitamin B12) transport and metabolism", "Defective MMAB causes methylmalonic aciduria type cblB"], "3267": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "3269": ["Histamine receptors", "G alpha (q) signalling events"], "327": ["Neutrophil degranulation", "Eukaryotic Translation Termination"], "3270": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "3273": ["Platelet degranulation ", "Dissolution of Fibrin Clot"], "3274": ["Histamine receptors", "G alpha (s) signalling events"], "3276": ["RMTs methylate histone arginines", "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "328": ["Displacement of DNA glycosylase by APEX1", "POLB-Dependent Long Patch Base Excision Repair", "Resolution of AP sites via the multiple-nucleotide patch replacement pathway", "PCNA-Dependent Long Patch Base Excision Repair", "Abasic sugar-phosphate removal via the single-nucleotide replacement pathway", "Resolution of Abasic Sites (AP sites)"], "3280": ["Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "NOTCH1 Intracellular Domain Regulates Transcription", "NOTCH2 intracellular domain regulates transcription", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "RUNX2 regulates osteoblast differentiation", "RUNX3 regulates NOTCH signaling", "RUNX3 regulates NOTCH signaling", "NOTCH3 Intracellular Domain Regulates Transcription", "NOTCH4 Intracellular Domain Regulates Transcription"], "3281": ["HSF1 activation", "Attenuation phase", "HSF1-dependent transactivation"], "3283": ["Androgen biosynthesis", "Mineralocorticoid biosynthesis", "Glucocorticoid biosynthesis"], "3284": ["Androgen biosynthesis", "Mineralocorticoid biosynthesis", "Glucocorticoid biosynthesis"], "329": ["Apoptotic cleavage of cellular proteins", "NOD1/2 Signaling Pathway", "TICAM1, RIP1-mediated IKK complex recruitment ", "RIPK1-mediated regulated necrosis", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "TNFR2 non-canonical NF-kB pathway", "Regulation of necroptotic cell death", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "Ub-specific processing proteases", "IKK complex recruitment mediated by RIP1"], "3290": ["Glucocorticoid biosynthesis"], "3291": ["Glucocorticoid biosynthesis"], "3292": ["Estrogen biosynthesis", "The canonical retinoid cycle in rods (twilight vision)"], "3293": ["Androgen biosynthesis", "Synthesis of very long-chain fatty acyl-CoAs"], "3294": ["Estrogen biosynthesis"], "3295": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "alpha-linolenic acid (ALA) metabolism", "Beta-oxidation of pristanoyl-CoA", "Beta-oxidation of very long chain fatty acids", "Peroxisomal protein import", "Peroxisomal protein import", "TYSND1 cleaves peroxisomal proteins"], "3297": ["Regulation of HSF1-mediated heat shock response", "HSF1 activation", "Attenuation phase", "HSF1-dependent transactivation"], "33": ["Beta oxidation of myristoyl-CoA to lauroyl-CoA", "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids", "Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA"], "330": ["NOD1/2 Signaling Pathway", "TICAM1, RIP1-mediated IKK complex recruitment ", "RIPK1-mediated regulated necrosis", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "TNFR2 non-canonical NF-kB pathway", "Regulation of necroptotic cell death", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "Ub-specific processing proteases", "IKK complex recruitment mediated by RIP1"], "3301": ["HSP90 chaperone cycle for steroid hormone receptors (SHR)"], "3303": ["Viral RNP Complexes in the Host Cell Nucleus", "Regulation of HSF1-mediated heat shock response", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Attenuation phase", "HSF1-dependent transactivation", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Neutrophil degranulation"], "3304": ["Viral RNP Complexes in the Host Cell Nucleus", "Regulation of HSF1-mediated heat shock response", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Attenuation phase", "HSF1-dependent transactivation", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Neutrophil degranulation"], "3305": ["Regulation of HSF1-mediated heat shock response", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Attenuation phase", "HSF1-dependent transactivation"], "3306": ["Meiotic synapsis", "Regulation of HSF1-mediated heat shock response", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Attenuation phase"], "3308": ["Regulation of HSF1-mediated heat shock response"], "3309": ["Platelet degranulation ", "Regulation of HSF1-mediated heat shock response", "ATF6 (ATF6-alpha) activates chaperones", "PERK regulates gene expression", "IRE1alpha activates chaperones", "ATF6 (ATF6-alpha) activates chaperone genes", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "331": ["Activation of caspases through apoptosome-mediated cleavage", "SMAC (DIABLO) binds to IAPs ", "SMAC (DIABLO) binds to IAPs ", "SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ", "SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ", "SMAC, XIAP-regulated apoptotic response", "Deactivation of the beta-catenin transactivating complex", "RIPK1-mediated regulated necrosis", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "Regulation of necroptotic cell death", "Regulation of PTEN localization", "Regulation of PTEN stability and activity", "Regulation of the apoptosome activity"], "3310": ["Regulation of HSF1-mediated heat shock response", "Neutrophil degranulation"], "3312": ["Regulation of HSF1-mediated heat shock response", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Attenuation phase", "HSF1-dependent transactivation", "Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis", "CHL1 interactions", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Interleukin-4 and Interleukin-13 signaling", "Neutrophil degranulation", "mRNA Splicing - Major Pathway", "Clathrin-mediated endocytosis", "Protein methylation", "GABA synthesis, release, reuptake and degradation"], "3313": ["Mitochondrial protein import", "Regulation of HSF1-mediated heat shock response", "Cristae formation", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "3315": ["VEGFA-VEGFR2 Pathway", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "MAPK6/MAPK4 signaling"], "332": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA replication proteins", "RHO GTPases Activate Formins", "Interleukin-4 and Interleukin-13 signaling", "TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "Mitotic Prometaphase", "Neddylation"], "3320": ["Signaling by ERBB2", "Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "vRNP Assembly", "Regulation of actin dynamics for phagocytic cup formation", "eNOS activation", "Regulation of PLK1 Activity at G2/M Transition", "Scavenging by Class F Receptors", "Scavenging by Class F Receptors", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "HSF1 activation", "Attenuation phase", "HSF1-dependent transactivation", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Sema3A PAK dependent Axon repulsion", "VEGFA-VEGFR2 Pathway", "VEGFA-VEGFR2 Pathway", "VEGFR2 mediated vascular permeability", "Uptake and function of diphtheria toxin", "PIWI-interacting RNA (piRNA) biogenesis", "Anchoring of the basal body to the plasma membrane", "Constitutive Signaling by EGFRvIII", "Interleukin-4 and Interleukin-13 signaling", "Neutrophil degranulation", "The role of GTSE1 in G2/M progression after G2 checkpoint", "AURKA Activation by TPX2", "Downregulation of ERBB2 signaling", "ESR-mediated signaling", "Estrogen-dependent gene expression"], "3326": ["Regulation of actin dynamics for phagocytic cup formation", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "HSF1 activation", "Attenuation phase", "HSF1-dependent transactivation", "Sema3A PAK dependent Axon repulsion", "Uptake and function of diphtheria toxin", "Neutrophil degranulation", "The NLRP3 inflammasome", "The role of GTSE1 in G2/M progression after G2 checkpoint", "Aryl hydrocarbon receptor signalling", "ESR-mediated signaling", "Estrogen-dependent gene expression"], "3329": ["Mitochondrial protein import", "Mitochondrial protein import", "TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation"], "3337": ["Regulation of HSF1-mediated heat shock response", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Attenuation phase", "HSF1-dependent transactivation", "MAPK6/MAPK4 signaling"], "3339": ["Degradation of the extracellular matrix", "Degradation of the extracellular matrix", "A tetrasaccharide linker sequence is required for GAG synthesis", "HS-GAG biosynthesis", "HS-GAG biosynthesis", "HS-GAG degradation", "Integrin cell surface interactions", "Laminin interactions", "Laminin interactions", "Non-integrin membrane-ECM interactions", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "Defective B4GALT7 causes EDS, progeroid type", "Defective B3GAT3 causes JDSSDHD", "Defective EXT2 causes exostoses 2", "Defective EXT1 causes exostoses 1, TRPS2 and CHDS", "Defective B3GALT6 causes EDSP2 and SEMDJL1", "Retinoid metabolism and transport", "Amyloid fiber formation"], "333932": ["Interleukin-7 signaling", "Interleukin-7 signaling", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "HDACs deacetylate histones", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "Chromatin modifying enzymes", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation", "Factors involved in megakaryocyte development and platelet production"], "334": ["Platelet degranulation ", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "3340": ["HS-GAG biosynthesis"], "3346": ["Antimicrobial peptides"], "3347": ["Antimicrobial peptides"], "335": ["Platelet degranulation ", "ABC transporters in lipid homeostasis", "PPARA activates gene expression", "Scavenging of heme from plasma", "Scavenging by Class B Receptors", "Scavenging by Class B Receptors", "Scavenging by Class A Receptors", "Scavenging by Class A Receptors", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation", "Chylomicron assembly", "HDL assembly", "Chylomicron remodeling", "HDL clearance", "HDL remodeling", "Retinoid metabolism and transport", "Retinoid metabolism and transport", "Amyloid fiber formation"], "3350": ["Serotonin receptors", "G alpha (i) signalling events"], "3351": ["Serotonin receptors", "G alpha (i) signalling events"], "3352": ["Serotonin receptors", "G alpha (i) signalling events"], "3354": ["Serotonin receptors", "G alpha (i) signalling events"], "3355": ["Serotonin receptors", "G alpha (i) signalling events"], "3356": ["Serotonin receptors", "G alpha (q) signalling events"], "3357": ["Serotonin receptors", "G alpha (q) signalling events"], "3358": ["Serotonin receptors", "G alpha (q) signalling events"], "3359": ["Neurotransmitter receptors and postsynaptic signal transmission"], "336": ["PPARA activates gene expression", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation", "Chylomicron assembly", "Chylomicron remodeling", "Retinoid metabolism and transport", "Retinoid metabolism and transport"], "3360": ["Serotonin receptors", "G alpha (s) signalling events"], "3361": ["Serotonin receptors", "G alpha (i) signalling events"], "3361711": ["Uptake and function of anthrax toxins"], "3361714": ["Uptake and function of anthrax toxins"], "3361726": ["Uptake and function of anthrax toxins"], "3362": ["Serotonin receptors", "G alpha (s) signalling events"], "3363": ["Serotonin receptors", "G alpha (s) signalling events"], "3364": ["Activation of ATR in response to replication stress", "HDR through Single Strand Annealing (SSA)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Regulation of TP53 Activity through Phosphorylation", "G2/M DNA damage checkpoint"], "3371": ["Integrin cell surface interactions", "Syndecan interactions", "ECM proteoglycans", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "3373": ["CS/DS degradation", "Hyaluronan uptake and degradation", "MPS IX - Natowicz syndrome"], "3375": ["Regulation of gene expression in beta cells", "G alpha (s) signalling events", "Calcitonin-like ligand receptors", "Amyloid fiber formation"], "3376": ["SeMet incorporation into proteins", "Cytosolic tRNA aminoacylation"], "337876": ["Chondroitin sulfate biosynthesis"], "337879": ["Keratinization"], "337880": ["Keratinization"], "337882": ["Keratinization"], "337959": ["Keratinization"], "337960": ["Keratinization"], "337963": ["Keratinization"], "337966": ["Keratinization"], "337967": ["Keratinization"], "337969": ["Keratinization"], "337970": ["Keratinization"], "337971": ["Keratinization"], "337972": ["Keratinization"], "337973": ["Keratinization"], "337974": ["Keratinization"], "337975": ["Keratinization"], "337976": ["Keratinization"], "337977": ["Keratinization"], "337978": ["Keratinization"], "337979": ["Keratinization"], "338": ["Cell surface interactions at the vascular wall", "Scavenging by Class B Receptors", "Scavenging by Class B Receptors", "Scavenging by Class A Receptors", "Scavenging by Class A Receptors", "Scavenging by Class F Receptors", "Scavenging by Class F Receptors", "Scavenging by Class H Receptors", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Platelet sensitization by LDL", "Regulation of TLR by endogenous ligand", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "VLDL assembly", "Post-translational protein phosphorylation", "Chylomicron assembly", "Chylomicron remodeling", "Chylomicron clearance", "Chylomicron clearance", "LDL clearance", "LDL clearance", "LDL remodeling", "VLDL clearance", "VLDL clearance", "Retinoid metabolism and transport", "Retinoid metabolism and transport"], "3381": ["Integrin cell surface interactions", "ECM proteoglycans"], "3383": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Integrin cell surface interactions", "Interleukin-10 signaling", "Interleukin-4 and Interleukin-13 signaling", "Interferon gamma signaling"], "338324": ["Metal sequestration by antimicrobial proteins"], "338328": ["Post-translational modification: synthesis of GPI-anchored proteins", "Assembly of active LPL and LIPC lipase complexes", "Chylomicron remodeling", "Retinoid metabolism and transport"], "338339": ["Dectin-2 family", "Neutrophil degranulation"], "338382": ["TBC/RABGAPs", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "338398": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "3384": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Integrin cell surface interactions", "CD209 (DC-SIGN) signaling"], "338440": ["Stimuli-sensing channels"], "338442": ["Hydroxycarboxylic acid-binding receptors", "Class A/1 (Rhodopsin-like receptors)", "G alpha (i) signalling events"], "3385": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Integrin cell surface interactions", "CD209 (DC-SIGN) signaling"], "338557": ["Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "G alpha (q) signalling events", "Free fatty acid receptors"], "338567": ["TWIK-related spinal cord K+ channel (TRESK)", "Phase 4 - resting membrane potential"], "338596": ["Sialic acid metabolism", "N-Glycan antennae elongation"], "3386": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Integrin cell surface interactions"], "338662": ["Olfactory Signaling Pathway"], "338674": ["Olfactory Signaling Pathway"], "338675": ["Olfactory Signaling Pathway"], "338751": ["Olfactory Signaling Pathway"], "338755": ["Olfactory Signaling Pathway"], "338785": ["Keratinization", "Formation of the cornified envelope"], "339": ["mRNA Editing: C to U Conversion", "Formation of the Editosome"], "339122": ["Retrograde transport at the Trans-Golgi-Network", "RAB geranylgeranylation"], "339221": ["Glycosphingolipid metabolism"], "339287": ["HATs acetylate histones"], "339327": ["Generic Transcription Pathway"], "339366": ["Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "339390": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "3394": ["Interferon gamma signaling", "Interferon alpha/beta signaling"], "339403": ["G alpha (i) signalling events", "Relaxin receptors"], "339487": ["tRNA processing in the nucleus"], "339488": ["Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "Activation of the TFAP2 (AP-2) family of transcription factors"], "339559": ["Generic Transcription Pathway"], "3396": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "3397": ["Oncogene Induced Senescence"], "339745": ["Hedgehog 'on' state"], "339896": ["Degradation of cysteine and homocysteine", "Amino acid synthesis and interconversion (transamination)"], "339983": ["Amino acid synthesis and interconversion (transamination)"], "34": ["PPARA activates gene expression", "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids", "Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "Beta oxidation of octanoyl-CoA to hexanoyl-CoA"], "340024": ["Amino acid transport across the plasma membrane", "Na+/Cl- dependent neurotransmitter transporters", "Defective SLC6A19 causes Hartnup disorder (HND)", "Defective SLC6A19 causes Hartnup disorder (HND)"], "340061": ["STING mediated induction of host immune responses", "Regulation of innate immune responses to cytosolic DNA", "STAT6-mediated induction of chemokines", "IRF3-mediated induction of type I IFN", "Neutrophil degranulation"], "340075": ["Glycosphingolipid metabolism", "The activation of arylsulfatases"], "340205": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "340252": ["Generic Transcription Pathway"], "340267": ["Collagen biosynthesis and modifying enzymes", "Collagen chain trimerization"], "340273": ["ABC-family proteins mediated transport"], "340348": ["Amyloid fiber formation"], "340351": ["Carboxyterminal post-translational modifications of tubulin"], "340385": ["Generic Transcription Pathway"], "340419": ["Regulation of FZD by ubiquitination"], "340481": ["eNOS activation"], "340485": ["Sphingolipid de novo biosynthesis"], "340654": ["Formation of the cornified envelope"], "340665": ["Vitamins", "RA biosynthesis pathway", "Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4)"], "340980": ["Olfactory Signaling Pathway"], "341": ["VLDL assembly", "VLDL clearance", "VLDL clearance"], "341152": ["Olfactory Signaling Pathway"], "341276": ["Olfactory Signaling Pathway"], "341359": ["Neurexins and neuroligins"], "341392": ["Conjugation of salicylate with glycine"], "341416": ["Olfactory Signaling Pathway"], "341418": ["Olfactory Signaling Pathway"], "341568": ["Olfactory Signaling Pathway"], "3416": ["Ub-specific processing proteases", "Peroxisomal protein import", "Peroxisomal protein import"], "3417": ["Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate", "NADPH regeneration", "Neutrophil degranulation", "Peroxisomal protein import", "Peroxisomal protein import"], "341799": ["Olfactory Signaling Pathway"], "3418": ["Transcriptional activation of mitochondrial biogenesis", "Citric acid cycle (TCA cycle)"], "3419": ["Citric acid cycle (TCA cycle)"], "3420": ["Citric acid cycle (TCA cycle)"], "3421": ["Mitochondrial protein import", "Citric acid cycle (TCA cycle)"], "342132": ["Generic Transcription Pathway"], "3422": ["Cholesterol biosynthesis", "Activation of gene expression by SREBF (SREBP)"], "3423": ["HS-GAG degradation", "CS/DS degradation", "MPS II - Hunter syndrome"], "3425": ["HS-GAG degradation", "CS/DS degradation", "MPS I - Hurler syndrome"], "342510": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "DAP12 interactions"], "342574": ["Keratinization", "Formation of the cornified envelope"], "3426": ["Regulation of Complement cascade"], "3428": ["STING mediated induction of host immune responses", "IRF3-mediated induction of type I IFN"], "3429": ["Interferon alpha/beta signaling"], "342926": ["Generic Transcription Pathway"], "343": ["Detoxification of Reactive Oxygen Species", "Passive transport by Aquaporins"], "3430": ["Interferon alpha/beta signaling"], "343169": ["Olfactory Signaling Pathway"], "343171": ["Olfactory Signaling Pathway"], "343172": ["Olfactory Signaling Pathway"], "343173": ["Olfactory Signaling Pathway"], "3433": ["Interferon alpha/beta signaling"], "3434": ["ISG15 antiviral mechanism", "Interferon alpha/beta signaling"], "343406": ["Olfactory Signaling Pathway"], "343563": ["Olfactory Signaling Pathway"], "343637": ["Regulation of FZD by ubiquitination"], "3437": ["Interferon alpha/beta signaling"], "3439": ["Interferon alpha/beta signaling", "Regulation of IFNA signaling", "Regulation of IFNA signaling", "TRAF6 mediated IRF7 activation", "Factors involved in megakaryocyte development and platelet production"], "344": ["Chylomicron assembly", "Assembly of active LPL and LIPC lipase complexes", "Chylomicron remodeling", "HDL remodeling", "Retinoid metabolism and transport", "Retinoid metabolism and transport"], "3440": ["Interferon alpha/beta signaling", "Regulation of IFNA signaling", "Regulation of IFNA signaling", "TRAF6 mediated IRF7 activation", "Factors involved in megakaryocyte development and platelet production"], "3441": ["Interferon alpha/beta signaling", "Regulation of IFNA signaling", "Regulation of IFNA signaling", "TRAF6 mediated IRF7 activation", "Factors involved in megakaryocyte development and platelet production"], "3442": ["Interferon alpha/beta signaling", "Regulation of IFNA signaling", "Regulation of IFNA signaling", "TRAF6 mediated IRF7 activation", "Factors involved in megakaryocyte development and platelet production"], "3443": ["Interferon alpha/beta signaling", "Regulation of IFNA signaling", "Regulation of IFNA signaling", "TRAF6 mediated IRF7 activation", "Factors involved in megakaryocyte development and platelet production"], "3444": ["Interferon alpha/beta signaling", "Regulation of IFNA signaling", "Regulation of IFNA signaling", "TRAF6 mediated IRF7 activation", "Factors involved in megakaryocyte development and platelet production"], "3445": ["Interferon alpha/beta signaling", "Regulation of IFNA signaling", "Regulation of IFNA signaling", "TRAF6 mediated IRF7 activation", "Factors involved in megakaryocyte development and platelet production"], "3446": ["Interferon alpha/beta signaling", "Regulation of IFNA signaling", "Regulation of IFNA signaling", "TRAF6 mediated IRF7 activation", "Factors involved in megakaryocyte development and platelet production"], "3447": ["Interferon alpha/beta signaling", "Regulation of IFNA signaling", "Regulation of IFNA signaling", "TRAF6 mediated IRF7 activation", "Factors involved in megakaryocyte development and platelet production"], "344787": ["Generic Transcription Pathway"], "3448": ["Interferon alpha/beta signaling", "Regulation of IFNA signaling", "Regulation of IFNA signaling", "TRAF6 mediated IRF7 activation", "Factors involved in megakaryocyte development and platelet production"], "344892": ["Olfactory Signaling Pathway"], "3449": ["Interferon alpha/beta signaling", "Regulation of IFNA signaling", "Regulation of IFNA signaling", "TRAF6 mediated IRF7 activation", "Factors involved in megakaryocyte development and platelet production"], "344905": ["Ion transport by P-type ATPases"], "345": ["Chylomicron assembly", "Chylomicron remodeling", "HDL remodeling", "Retinoid metabolism and transport", "Retinoid metabolism and transport"], "3451": ["Interferon alpha/beta signaling", "Regulation of IFNA signaling", "Regulation of IFNA signaling", "TRAF6 mediated IRF7 activation", "Factors involved in megakaryocyte development and platelet production"], "3452": ["Interferon alpha/beta signaling", "Regulation of IFNA signaling", "Regulation of IFNA signaling", "TRAF6 mediated IRF7 activation", "Factors involved in megakaryocyte development and platelet production"], "345274": ["Transport of bile salts and organic acids, metal ions and amine compounds"], "345275": ["Lipid particle organization"], "3454": ["Interferon alpha/beta signaling", "Regulation of IFNA signaling", "Regulation of IFNA signaling"], "3455": ["Interferon alpha/beta signaling", "Regulation of IFNA signaling", "Regulation of IFNA signaling"], "3456": ["Oxidative Stress Induced Senescence", "Interferon alpha/beta signaling", "Regulation of IFNA signaling", "Regulation of IFNA signaling", "TRAF3-dependent IRF activation pathway", "TRAF6 mediated IRF7 activation", "Factors involved in megakaryocyte development and platelet production"], "3458": ["Interferon gamma signaling", "Regulation of IFNG signaling", "Regulation of IFNG signaling", "RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "3459": ["Interferon gamma signaling", "Regulation of IFNG signaling", "Regulation of IFNG signaling"], "346": ["VLDL assembly", "VLDL clearance", "VLDL clearance"], "3460": ["Interferon gamma signaling", "Regulation of IFNG signaling", "Regulation of IFNG signaling"], "346517": ["Olfactory Signaling Pathway"], "346525": ["Olfactory Signaling Pathway"], "346528": ["Olfactory Signaling Pathway"], "346562": ["PLC beta mediated events", "PLC beta mediated events", "Adenylate cyclase inhibitory pathway", "Adenylate cyclase inhibitory pathway", "G-protein activation", "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "ADP signalling through P2Y purinoceptor 12", "G alpha (s) signalling events", "G alpha (i) signalling events", "G alpha (i) signalling events", "G alpha (z) signalling events", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "346606": ["Triglyceride biosynthesis"], "347": ["Transport of fatty acids"], "347148": ["Orexin and neuropeptides FF and QRFP bind to their respective receptors", "G alpha (q) signalling events"], "347168": ["Olfactory Signaling Pathway"], "347169": ["Olfactory Signaling Pathway"], "347240": ["Anchoring of the basal body to the plasma membrane"], "347468": ["Olfactory Signaling Pathway"], "347516": ["Acyl chain remodeling of DAG and TAG"], "347517": ["Intra-Golgi traffic", "RAB geranylgeranylation"], "347527": ["Glycosphingolipid metabolism", "The activation of arylsulfatases"], "347688": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "Gap junction assembly", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Recruitment of NuMA to mitotic centrosomes", "Recycling pathway of L1", "Recycling pathway of L1", "Cilium Assembly", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "Carboxyterminal post-translational modifications of tubulin", "Carboxyterminal post-translational modifications of tubulin", "Activation of AMPK downstream of NMDARs", "Kinesins"], "347730": ["Neurexins and neuroligins"], "347731": ["Neurexins and neuroligins"], "347732": ["Sperm Motility And Taxes"], "347733": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "Gap junction assembly", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Recruitment of NuMA to mitotic centrosomes", "Prefoldin mediated transfer of substrate to CCT/TriC", "Formation of tubulin folding intermediates by CCT/TriC", "Post-chaperonin tubulin folding pathway", "Recycling pathway of L1", "Recycling pathway of L1", "Hedgehog 'off' state", "Cilium Assembly", "Intraflagellar transport", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "Carboxyterminal post-translational modifications of tubulin", "Carboxyterminal post-translational modifications of tubulin", "Activation of AMPK downstream of NMDARs", "Kinesins"], "347734": ["Transport and synthesis of PAPS", "Transport of nucleotide sugars"], "347735": ["Serine biosynthesis"], "3479": ["Platelet degranulation ", "Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "IRS-related events triggered by IGF1R", "SHC-related events triggered by IGF1R", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Synthesis, secretion, and deacylation of Ghrelin"], "348": ["Scavenging by Class A Receptors", "Scavenging by Class A Receptors", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors", "Post-translational protein phosphorylation", "Chylomicron assembly", "Chylomicron remodeling", "Chylomicron clearance", "Chylomicron clearance", "HDL remodeling", "Retinoid metabolism and transport", "Retinoid metabolism and transport"], "3480": ["Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "IRS-related events triggered by IGF1R", "SHC-related events triggered by IGF1R"], "3481": ["Platelet degranulation ", "Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "IRS-related events triggered by IGF1R", "SHC-related events triggered by IGF1R", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "348158": ["Conjugation of salicylate with glycine", "Conjugation of benzoate with glycine", "Conjugation of phenylacetate with glutamine"], "348180": ["tRNA modification in the nucleus and cytosol"], "3482": ["Golgi Associated Vesicle Biogenesis", "Neutrophil degranulation", "Retrograde transport at the Trans-Golgi-Network", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "348235": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "3483": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "348327": ["Generic Transcription Pathway"], "3484": ["ATF4 activates genes", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes"], "3485": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "3486": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "TP53 Regulates Transcription of Death Receptors and Ligands", "Post-translational protein phosphorylation"], "348654": ["Resolution of D-loop Structures through Holliday Junction Intermediates"], "3487": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "3488": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "3489": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "348932": ["Amino acid transport across the plasma membrane", "Na+/Cl- dependent neurotransmitter transporters", "Defective SLC6A18 may confer susceptibility to iminoglycinuria and/or hyperglycinuria", "Defective SLC6A18 may confer susceptibility to iminoglycinuria and/or hyperglycinuria"], "348938": ["Miscellaneous transport and binding events"], "348980": ["HCN channels"], "348995": ["ISG15 antiviral mechanism", "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "RHO GTPases Activate Formins", "tRNA processing in the nucleus", "Mitotic Prometaphase"], "3490": ["Senescence-Associated Secretory Phenotype (SASP)", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "3491": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "349565": ["Nicotinate metabolism"], "349633": ["Post-translational modification: synthesis of GPI-anchored proteins"], "349667": ["Post-translational modification: synthesis of GPI-anchored proteins"], "35": ["Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "Beta oxidation of butanoyl-CoA to acetyl-CoA"], "350": ["Platelet degranulation "], "351": ["Platelet degranulation ", "ECM proteoglycans", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "G alpha (q) signalling events", "G alpha (i) signalling events", "Lysosome Vesicle Biogenesis", "Formyl peptide receptors bind formyl peptides and many other ligands", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "The NLRP3 inflammasome", "Advanced glycosylation endproduct receptor signaling", "Advanced glycosylation endproduct receptor signaling", "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "Post-translational protein phosphorylation", "TRAF6 mediated NF-kB activation", "Amyloid fiber formation"], "3512": ["Cell surface interactions at the vascular wall", "Scavenging of heme from plasma"], "3516": ["Pre-NOTCH Transcription and Translation", "Pre-NOTCH Transcription and Translation", "Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "NOTCH1 Intracellular Domain Regulates Transcription", "NOTCH1 Intracellular Domain Regulates Transcription", "NOTCH2 intracellular domain regulates transcription", "NOTCH2 intracellular domain regulates transcription", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "Notch-HLH transcription pathway", "RUNX3 regulates NOTCH signaling", "RUNX3 regulates NOTCH signaling", "NOTCH3 Intracellular Domain Regulates Transcription", "NOTCH3 Intracellular Domain Regulates Transcription", "NOTCH4 Intracellular Domain Regulates Transcription", "NOTCH4 Intracellular Domain Regulates Transcription"], "353": ["Neutrophil degranulation", "Purine salvage"], "353088": ["Generic Transcription Pathway"], "353091": ["Post-translational modification: synthesis of GPI-anchored proteins"], "353131": ["Formation of the cornified envelope"], "353132": ["Formation of the cornified envelope"], "353133": ["Formation of the cornified envelope"], "353134": ["Formation of the cornified envelope"], "353135": ["Formation of the cornified envelope"], "353137": ["Formation of the cornified envelope"], "353139": ["Formation of the cornified envelope"], "353140": ["Formation of the cornified envelope"], "353141": ["Formation of the cornified envelope"], "353142": ["Formation of the cornified envelope"], "353143": ["Formation of the cornified envelope"], "353144": ["Formation of the cornified envelope"], "353145": ["Formation of the cornified envelope"], "353189": ["Neutrophil degranulation", "Transport of organic anions"], "353238": ["Chromatin modifying enzymes"], "353274": ["Generic Transcription Pathway"], "353288": ["Keratinization", "Formation of the cornified envelope"], "353299": ["G alpha (q) signalling events", "G alpha (i) signalling events", "G alpha (z) signalling events"], "353323": ["Keratinization"], "353332": ["Keratinization"], "353333": ["Keratinization"], "353355": ["Generic Transcription Pathway"], "353376": ["Caspase activation via Death Receptors in the presence of ligand", "Toll Like Receptor 4 (TLR4) Cascade", "MyD88-independent TLR4 cascade ", "TRIF-mediated programmed cell death", "Neutrophil degranulation", "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon", "IKK complex recruitment mediated by RIP1", "TRAF6-mediated induction of TAK1 complex within TLR4 complex", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"], "353497": ["Fanconi Anemia Pathway"], "353514": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "354": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3"], "3543": ["Cell surface interactions at the vascular wall"], "3549": ["Class B/2 (Secretin family receptors)", "Hedgehog ligand biogenesis", "Release of Hh-Np from the secreting cell", "Release of Hh-Np from the secreting cell", "Ligand-receptor interactions", "Ligand-receptor interactions", "Hedgehog 'on' state", "Activation of SMO", "HHAT G278V abrogates palmitoylation of Hh-Np", "RUNX2 regulates chondrocyte maturation"], "355": ["Caspase activation via Death Receptors in the presence of ligand", "Regulation by c-FLIP", "RIPK1-mediated regulated necrosis", "CASP8 activity is inhibited", "TP53 Regulates Transcription of Death Receptors and Ligands", "Dimerization of procaspase-8", "FasL/ CD95L signaling"], "3551": ["Activation of NF-kappaB in B cells", "Activation of NF-kappaB in B cells", "ER-Phagosome pathway", "NOD1/2 Signaling Pathway", "TICAM1, RIP1-mediated IKK complex recruitment ", "RIP-mediated NFkB activation via ZBP1", "Downstream TCR signaling", "p75NTR recruits signalling complexes", "NF-kB is activated and signals survival", "FCERI mediated NF-kB activation", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "IKBKB deficiency causes SCID", "IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)", "IkBA variant leads to EDA-ID", "CLEC7A (Dectin-1) signaling", "MAP3K8 (TPL2)-dependent MAPK1/3 activation", "Interleukin-1 signaling", "TRAF6 mediated NF-kB activation", "NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10", "IRAK1 recruits IKK complex", "IKK complex recruitment mediated by RIP1", "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation"], "3552": ["Senescence-Associated Secretory Phenotype (SASP)", "Interleukin-1 processing", "Interleukin-10 signaling", "Interleukin-4 and Interleukin-13 signaling", "Interleukin-1 signaling"], "3553": ["Interleukin-1 processing", "CLEC7A/inflammasome pathway", "Interleukin-10 signaling", "Interleukin-4 and Interleukin-13 signaling", "Interleukin-1 signaling"], "3554": ["Interleukin-10 signaling", "Interleukin-1 signaling"], "35556781": ["ER-Phagosome pathway", "MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "Toll Like Receptor TLR6:TLR2 Cascade", "MyD88 deficiency (TLR2/4)", "IRAK4 deficiency (TLR2/4)"], "3556": ["PIP3 activates AKT signaling", "Receptor-type tyrosine-protein phosphatases", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Interleukin-36 pathway", "Interleukin-33 signaling", "Interleukin-1 signaling"], "3557": ["Interleukin-10 signaling", "Interleukin-1 signaling"], "3558": ["RAF/MAP kinase cascade", "RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "Interleukin-2 signaling", "Interleukin receptor SHC signaling"], "3559": ["RAF/MAP kinase cascade", "RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "Interleukin-2 signaling", "Interleukin receptor SHC signaling"], "356": ["Caspase activation via Death Receptors in the presence of ligand", "Regulation by c-FLIP", "RIPK1-mediated regulated necrosis", "CASP8 activity is inhibited", "TNFs bind their physiological receptors", "Interleukin-4 and Interleukin-13 signaling", "Dimerization of procaspase-8", "FasL/ CD95L signaling", "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "FOXO-mediated transcription of cell death genes"], "3560": ["RAF/MAP kinase cascade", "Interleukin-15 signaling", "Interleukin-15 signaling", "Interleukin-2 signaling", "Interleukin receptor SHC signaling"], "3561": ["Interleukin-7 signaling", "Interleukin-7 signaling", "RAF/MAP kinase cascade", "Interleukin-4 and Interleukin-13 signaling", "Interleukin-15 signaling", "Interleukin-15 signaling", "Interleukin-9 signaling", "Interleukin-2 signaling", "Interleukin-21 signaling", "Interleukin receptor SHC signaling"], "3562": ["Interleukin-3, Interleukin-5 and GM-CSF signaling", "RAF/MAP kinase cascade", "RUNX1 regulates transcription of genes involved in interleukin signaling", "Interleukin receptor SHC signaling"], "3563": ["Interleukin-3, Interleukin-5 and GM-CSF signaling", "RAF/MAP kinase cascade", "Interleukin receptor SHC signaling"], "3565": ["Interleukin-4 and Interleukin-13 signaling", "Interleukin-18 signaling"], "3566": ["Interleukin-4 and Interleukin-13 signaling"], "3567": ["Interleukin-3, Interleukin-5 and GM-CSF signaling", "RAF/MAP kinase cascade", "Interleukin receptor SHC signaling"], "3568": ["Interleukin-3, Interleukin-5 and GM-CSF signaling", "RAF/MAP kinase cascade", "Interleukin receptor SHC signaling"], "3569": ["Interleukin-6 signaling", "MAPK3 (ERK1) activation", "MAPK1 (ERK2) activation", "Senescence-Associated Secretory Phenotype (SASP)", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Interleukin-10 signaling", "Interleukin-4 and Interleukin-13 signaling", "Post-translational protein phosphorylation"], "3570": ["Interleukin-6 signaling", "MAPK3 (ERK1) activation", "MAPK1 (ERK2) activation", "Interleukin-4 and Interleukin-13 signaling"], "3572": ["Interleukin-6 signaling", "Interleukin-6 signaling", "MAPK3 (ERK1) activation", "MAPK1 (ERK2) activation", "IL-6-type cytokine receptor ligand interactions", "Interleukin-35 Signalling", "Interleukin-27 signaling", "Interleukin-27 signaling"], "3574": ["Interleukin-7 signaling", "Interleukin-7 signaling"], "3575": ["Interleukin-7 signaling", "Interleukin-7 signaling", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "3576": ["Senescence-Associated Secretory Phenotype (SASP)", "Peptide ligand-binding receptors", "Chemokine receptors bind chemokines", "ATF4 activates genes", "G alpha (i) signalling events", "Interleukin-10 signaling", "Interleukin-4 and Interleukin-13 signaling"], "3577": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events", "Neutrophil degranulation"], "3578": ["Interleukin-9 signaling"], "3579": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events", "Neutrophil degranulation"], "358": ["Erythrocytes take up carbon dioxide and release oxygen", "Erythrocytes take up oxygen and release carbon dioxide", "Vasopressin regulates renal water homeostasis via Aquaporins", "Passive transport by Aquaporins"], "3581": ["Interleukin-9 signaling"], "3586": ["Interleukin-10 signaling", "Interleukin-4 and Interleukin-13 signaling", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "3587": ["Interleukin-10 signaling"], "3588": ["Other interleukin signaling", "Interleukin-10 signaling", "Interleukin-20 family signaling"], "3589": ["IL-6-type cytokine receptor ligand interactions"], "359": ["Vasopressin regulates renal water homeostasis via Aquaporins", "Passive transport by Aquaporins"], "3590": ["IL-6-type cytokine receptor ligand interactions"], "3592": ["Interleukin-10 signaling", "Interleukin-4 and Interleukin-13 signaling", "Interleukin-35 Signalling", "Interleukin-12 signaling", "Interleukin-12 signaling"], "3593": ["Interleukin-10 signaling", "Interleukin-4 and Interleukin-13 signaling", "Interleukin-12 signaling", "Interleukin-12 signaling", "Interleukin-23 signaling", "Interleukin-23 signaling"], "3594": ["Interleukin-12 signaling", "Interleukin-12 signaling", "Interleukin-23 signaling", "Interleukin-23 signaling"], "3595": ["Interleukin-35 Signalling", "Interleukin-12 signaling", "Interleukin-12 signaling"], "3596": ["Interleukin-4 and Interleukin-13 signaling", "Interleukin-18 signaling"], "3597": ["Interleukin-4 and Interleukin-13 signaling"], "3598": ["Interleukin-4 and Interleukin-13 signaling"], "36": ["Branched-chain amino acid catabolism"], "360": ["Vasopressin regulates renal water homeostasis via Aquaporins", "Passive transport by Aquaporins"], "3600": ["Interleukin-15 signaling", "Interleukin-15 signaling"], "3601": ["Interleukin-15 signaling", "Interleukin-15 signaling"], "3603": ["Other interleukin signaling"], "3604": ["TNFs bind their physiological receptors"], "3605": ["Interleukin-17 signaling", "Interleukin-4 and Interleukin-13 signaling"], "3606": ["Interleukin-1 processing", "Interleukin-10 signaling", "Interleukin-4 and Interleukin-13 signaling", "Interleukin-18 signaling"], "3607": ["UCH proteinases"], "3608": ["Neutrophil degranulation"], "361": ["Vasopressin regulates renal water homeostasis via Aquaporins", "Passive transport by Aquaporins"], "3611": ["Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "Cell-extracellular matrix interactions"], "3612": ["Synthesis of IP2, IP, and Ins in the cytosol"], "3613": ["Synthesis of IP2, IP, and Ins in the cytosol"], "3614": ["Neutrophil degranulation", "Purine ribonucleoside monophosphate biosynthesis"], "3615": ["Neutrophil degranulation", "Purine ribonucleoside monophosphate biosynthesis"], "3619": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA replication proteins", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "362": ["Passive transport by Aquaporins"], "3620": ["Tryptophan catabolism"], "3622": ["SUMOylation of transcription cofactors", "PI5P Regulates TP53 Acetylation"], "3623": ["Glycoprotein hormones"], "3624": ["Signaling by Activin", "Signaling by Activin", "Glycoprotein hormones", "Antagonism of Activin by Follistatin"], "3625": ["Signaling by Activin", "Signaling by Activin", "Glycoprotein hormones", "Antagonism of Activin by Follistatin"], "3626": ["Glycoprotein hormones"], "3627": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events", "Interleukin-10 signaling"], "3628": ["Synthesis of IP2, IP, and Ins in the cytosol"], "363": ["Passive transport by Aquaporins"], "3630": ["Regulation of gene expression in beta cells", "Insulin processing", "Insulin processing", "Synthesis, secretion, and deacylation of Ghrelin", "Regulation of insulin secretion", "COPI-mediated anterograde transport", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "IRS activation", "Signal attenuation", "Insulin receptor signalling cascade", "Signaling by Insulin receptor", "Insulin receptor recycling", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "Amyloid fiber formation"], "3631": ["Synthesis of PIPs at the plasma membrane", "Synthesis of PIPs at the early endosome membrane", "Synthesis of IP2, IP, and Ins in the cytosol"], "3632": ["Synthesis of IP2, IP, and Ins in the cytosol"], "3633": ["Synthesis of IP2, IP, and Ins in the cytosol", "Synthesis of IP3 and IP4 in the cytosol", "Rho GTPase cycle"], "3635": ["Synthesis of PIPs at the plasma membrane", "Synthesis of IP3 and IP4 in the cytosol", "Downstream TCR signaling", "PECAM1 interactions", "Interleukin receptor SHC signaling"], "3636": ["Synthesis of PIPs at the plasma membrane", "Synthesis of IP3 and IP4 in the cytosol", "Interleukin receptor SHC signaling"], "3636229": ["Antimicrobial peptides"], "3638": ["Regulation of cholesterol biosynthesis by SREBP (SREBF)"], "364": ["Transport of glycerol from adipocytes to the liver by Aquaporins", "Passive transport by Aquaporins"], "3640": ["G alpha (s) signalling events", "Relaxin receptors"], "3642": ["Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells"], "3643": ["PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "IRS activation", "Signal attenuation", "Insulin receptor signalling cascade", "Signaling by Insulin receptor", "Insulin receptor recycling"], "3644711": ["Antimicrobial peptides"], "3646": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "3651": ["Regulation of gene expression in beta cells", "Regulation of gene expression in early pancreatic precursor cells"], "3654": ["PIP3 activates AKT signaling", "MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "NOD1/2 Signaling Pathway", "p75NTR recruits signalling complexes", "p75NTR recruits signalling complexes", "NF-kB is activated and signals survival", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "activated TAK1 mediates p38 MAPK activation", "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Transcriptional Regulation by MECP2", "Interleukin-1 signaling", "IRAK1 recruits IKK complex", "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "MyD88 dependent cascade initiated on endosome", "MyD88 cascade initiated on plasma membrane"], "3655": ["Assembly of collagen fibrils and other multimeric structures", "Basigin interactions", "Integrin cell surface interactions", "Integrin cell surface interactions", "Laminin interactions", "Laminin interactions", "Syndecan interactions", "Type I hemidesmosome assembly"], "3656": ["MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "NOD1/2 Signaling Pathway", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "activated TAK1 mediates p38 MAPK activation", "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "Interleukin-1 signaling", "IRAK2 mediated activation of TAK1 complex", "TRAF6-mediated induction of TAK1 complex within TLR4 complex", "TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "MyD88 dependent cascade initiated on endosome", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "MyD88 cascade initiated on plasma membrane"], "3658": ["Iron uptake and transport"], "3659": ["Interferon gamma signaling", "Interferon alpha/beta signaling", "Factors involved in megakaryocyte development and platelet production"], "366": ["Transport of glycerol from adipocytes to the liver by Aquaporins", "Passive transport by Aquaporins"], "3660": ["Interferon gamma signaling", "Interferon alpha/beta signaling", "Factors involved in megakaryocyte development and platelet production"], "3661": ["ISG15 antiviral mechanism", "IRF3 mediated activation of type 1 IFN", "IRF3 mediated activation of type 1 IFN", "LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "Regulation of innate immune responses to cytosolic DNA", "IRF3-mediated induction of type I IFN", "Interferon gamma signaling", "TICAM1-dependent activation of IRF3/IRF7", "Interferon alpha/beta signaling", "TRAF3-dependent IRF activation pathway", "TRAF6 mediated IRF7 activation", "Negative regulators of DDX58/IFIH1 signaling", "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon"], "3662": ["Interleukin-4 and Interleukin-13 signaling", "Interferon gamma signaling", "Interferon alpha/beta signaling"], "3663": ["Interferon gamma signaling", "Interferon alpha/beta signaling"], "3664": ["Interferon gamma signaling", "Interferon alpha/beta signaling"], "3665": ["DEx/H-box helicases activate type I IFN and inflammatory cytokines production ", "Interferon gamma signaling", "TICAM1-dependent activation of IRF3/IRF7", "Interferon alpha/beta signaling", "TRAF3-dependent IRF activation pathway", "TRAF6 mediated IRF7 activation", "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon", "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling"], "3667": ["PI3K Cascade", "IRS-mediated signalling", "SOS-mediated signalling", "SOS-mediated signalling", "PIP3 activates AKT signaling", "Interleukin-7 signaling", "PI3K/AKT activation", "PI3K/AKT activation", "Constitutive Signaling by Aberrant PI3K in Cancer", "IRS-related events triggered by IGF1R", "Signaling by Leptin", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "IRS activation", "Signal attenuation", "Activated NTRK3 signals through PI3K", "Growth hormone receptor signaling"], "3669": ["Interferon alpha/beta signaling"], "367": ["HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Nuclear Receptor transcription pathway", "SUMOylation of intracellular receptors", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Ub-specific processing proteases", "RUNX2 regulates osteoblast differentiation", "RUNX2 regulates osteoblast differentiation"], "3670": ["Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)", "Regulation of expression of SLITs and ROBOs"], "3671": ["Platelet degranulation "], "3672": ["Integrin cell surface interactions", "Integrin cell surface interactions", "Laminin interactions", "Other semaphorin interactions", "Smooth Muscle Contraction", "CHL1 interactions", "Platelet Adhesion to exposed collagen"], "3673": ["Integrin cell surface interactions", "Integrin cell surface interactions", "Laminin interactions", "Laminin interactions", "Syndecan interactions", "ECM proteoglycans", "CHL1 interactions", "Platelet Adhesion to exposed collagen", "MET activates PTK2 signaling"], "3674": ["Platelet degranulation ", "Integrin cell surface interactions", "ECM proteoglycans", "Integrin alphaIIb beta3 signaling", "GRB2:SOS provides linkage to MAPK signaling for Integrins ", "p130Cas linkage to MAPK signaling for integrins", "Signal transduction by L1", "MAP2K and MAPK activation", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"], "3675": ["Basigin interactions", "Integrin cell surface interactions", "Integrin cell surface interactions", "Laminin interactions", "MET activates PTK2 signaling"], "3676": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "Integrin cell surface interactions", "Integrin cell surface interactions", "RUNX3 Regulates Immune Response and Cell Migration"], "3678": ["Elastic fibre formation", "Fibronectin matrix formation", "Cell surface interactions at the vascular wall", "Integrin cell surface interactions", "Integrin cell surface interactions", "Signal transduction by L1", "RUNX2 regulates genes involved in cell migration"], "3679": ["Integrin cell surface interactions", "Laminin interactions", "Laminin interactions", "ECM proteoglycans"], "368": ["ABC-family proteins mediated transport", "Defective ABCC6 causes pseudoxanthoma elasticum (PXE)"], "3680": ["Integrin cell surface interactions", "Integrin cell surface interactions", "ECM proteoglycans", "Signal transduction by L1"], "3681": ["Integrin cell surface interactions"], "3682": ["Integrin cell surface interactions"], "3683": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "Integrin cell surface interactions", "Neutrophil degranulation", "RUNX3 Regulates Immune Response and Cell Migration"], "3684": ["Toll Like Receptor 4 (TLR4) Cascade", "Cell surface interactions at the vascular wall", "Integrin cell surface interactions", "Interleukin-4 and Interleukin-13 signaling", "Neutrophil degranulation"], "3685": ["Cross-presentation of particulate exogenous antigens (phagosomes)", "Elastic fibre formation", "PECAM1 interactions", "Molecules associated with elastic fibres", "Integrin cell surface interactions", "Integrin cell surface interactions", "Laminin interactions", "Syndecan interactions", "Syndecan interactions", "ECM proteoglycans", "VEGFA-VEGFR2 Pathway", "Signal transduction by L1", "Neutrophil degranulation"], "3687": ["Cell surface interactions at the vascular wall", "Integrin cell surface interactions", "ECM proteoglycans", "Interleukin-4 and Interleukin-13 signaling", "Neutrophil degranulation"], "3688": ["Elastic fibre formation", "Fibronectin matrix formation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "Basigin interactions", "Molecules associated with elastic fibres", "Integrin cell surface interactions", "Integrin cell surface interactions", "Laminin interactions", "Laminin interactions", "Syndecan interactions", "ECM proteoglycans", "Other semaphorin interactions", "Signal transduction by L1", "Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "CHL1 interactions", "RHO GTPases Activate Formins", "Interleukin-4 and Interleukin-13 signaling", "Platelet Adhesion to exposed collagen", "MET activates PTK2 signaling", "MET interacts with TNS proteins"], "3689": ["Toll Like Receptor 4 (TLR4) Cascade", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "Integrin cell surface interactions", "Interleukin-4 and Interleukin-13 signaling", "Neutrophil degranulation"], "369": ["RAF activation", "MAP2K and MAPK activation", "Negative regulation of MAPK pathway", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF"], "3690": ["Platelet degranulation ", "Elastic fibre formation", "PECAM1 interactions", "Molecules associated with elastic fibres", "Integrin cell surface interactions", "Integrin cell surface interactions", "Syndecan interactions", "Syndecan interactions", "ECM proteoglycans", "Integrin alphaIIb beta3 signaling", "GRB2:SOS provides linkage to MAPK signaling for Integrins ", "p130Cas linkage to MAPK signaling for integrins", "VEGFA-VEGFR2 Pathway", "Signal transduction by L1", "MAP2K and MAPK activation", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF"], "3691": ["Assembly of collagen fibrils and other multimeric structures", "Laminin interactions", "Syndecan interactions", "Type I hemidesmosome assembly"], "3693": ["Cross-presentation of particulate exogenous antigens (phagosomes)", "Molecules associated with elastic fibres", "Integrin cell surface interactions", "Integrin cell surface interactions", "Syndecan interactions", "Syndecan interactions", "ECM proteoglycans", "Smooth Muscle Contraction"], "3694": ["Elastic fibre formation", "Molecules associated with elastic fibres", "Integrin cell surface interactions", "ECM proteoglycans"], "3695": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Integrin cell surface interactions"], "3696": ["Molecules associated with elastic fibres", "Integrin cell surface interactions"], "3698": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "3699": ["Platelet degranulation "], "37": ["XBP1(S) activates chaperone genes", "Beta oxidation of palmitoyl-CoA to myristoyl-CoA"], "3700": ["Platelet degranulation "], "3702": ["Generation of second messenger molecules", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization"], "3703": ["Asparagine N-linked glycosylation"], "3704": ["Purine catabolism"], "3705": ["Synthesis of pyrophosphates in the cytosol", "Synthesis of IP3 and IP4 in the cytosol", "Factors involved in megakaryocyte development and platelet production"], "3706": ["Synthesis of IP3 and IP4 in the cytosol"], "3707": ["Synthesis of IP3 and IP4 in the cytosol"], "3707572": ["CASP8 activity is inhibited", "Regulation of TNFR1 signaling"], "3708": ["PLC beta mediated events", "Effects of PIP2 hydrolysis", "Elevation of cytosolic Ca2+ levels", "DAG and IP3 signaling", "Role of phospholipids in phagocytosis", "FCERI mediated Ca+2 mobilization", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Ca2+ pathway", "cGMP effects", "Regulation of insulin secretion", "VEGFR2 mediated cell proliferation", "Ion homeostasis", "Ion homeostasis", "CLEC7A (Dectin-1) induces NFAT activation", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "3709": ["PLC beta mediated events", "Effects of PIP2 hydrolysis", "Elevation of cytosolic Ca2+ levels", "DAG and IP3 signaling", "Role of phospholipids in phagocytosis", "FCERI mediated Ca+2 mobilization", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Ca2+ pathway", "Regulation of insulin secretion", "VEGFR2 mediated cell proliferation", "Ion homeostasis", "Ion homeostasis", "CLEC7A (Dectin-1) induces NFAT activation", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "3710": ["PLC beta mediated events", "Effects of PIP2 hydrolysis", "Elevation of cytosolic Ca2+ levels", "DAG and IP3 signaling", "Role of phospholipids in phagocytosis", "FCERI mediated Ca+2 mobilization", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Ca2+ pathway", "Regulation of insulin secretion", "VEGFR2 mediated cell proliferation", "Ion homeostasis", "Ion homeostasis", "CLEC7A (Dectin-1) induces NFAT activation", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "3712": ["Branched-chain amino acid catabolism"], "3713": ["Formation of the cornified envelope"], "3714": ["Activated NOTCH1 Transmits Signal to the Nucleus", "Activated NOTCH1 Transmits Signal to the Nucleus", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant", "Constitutive Signaling by NOTCH1 HD Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "NOTCH2 Activation and Transmission of Signal to the Nucleus", "NOTCH3 Activation and Transmission of Signal to the Nucleus", "NOTCH3 Activation and Transmission of Signal to the Nucleus"], "3716": ["Interleukin-6 signaling", "Interleukin-6 signaling", "MAPK3 (ERK1) activation", "MAPK1 (ERK2) activation", "ISG15 antiviral mechanism", "Interleukin-7 signaling", "Interleukin-7 signaling", "Other interleukin signaling", "RAF/MAP kinase cascade", "Interleukin-10 signaling", "Interleukin-4 and Interleukin-13 signaling", "IL-6-type cytokine receptor ligand interactions", "Interferon gamma signaling", "Regulation of IFNG signaling", "Regulation of IFNG signaling", "Interleukin-20 family signaling", "Interleukin-15 signaling", "Interleukin-15 signaling", "Interleukin-35 Signalling", "Interleukin-9 signaling", "Interleukin-2 signaling", "Interleukin-12 signaling", "Interleukin-12 signaling", "Interleukin-27 signaling", "Interleukin-27 signaling", "Interleukin-21 signaling", "Interferon alpha/beta signaling", "Interleukin receptor SHC signaling", "Regulation of IFNA signaling", "Regulation of IFNA signaling"], "3717": ["Interleukin-6 signaling", "Interleukin-6 signaling", "MAPK3 (ERK1) activation", "MAPK1 (ERK2) activation", "Prolactin receptor signaling", "Prolactin receptor signaling", "Signaling by SCF-KIT", "Signaling by Leptin", "RMTs methylate histone arginines", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "RAF activation", "RAF/MAP kinase cascade", "Interleukin-4 and Interleukin-13 signaling", "IL-6-type cytokine receptor ligand interactions", "Signaling by moderate kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF", "Cyclin D associated events in G1", "Interferon gamma signaling", "Regulation of IFNG signaling", "Regulation of IFNG signaling", "Interleukin-20 family signaling", "Interleukin-35 Signalling", "Signaling by Erythropoietin", "Interleukin-12 signaling", "Interleukin-12 signaling", "Interleukin-23 signaling", "Interleukin-23 signaling", "Interleukin-27 signaling", "Interleukin-27 signaling", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "Erythropoietin activates Phospholipase C gamma (PLCG)", "Erythropoietin activates STAT5", "Erythropoietin activates RAS", "Erythropoietin activates RAS", "Interleukin receptor SHC signaling", "Growth hormone receptor signaling", "Growth hormone receptor signaling", "Factors involved in megakaryocyte development and platelet production"], "3718": ["Interleukin-7 signaling", "Interleukin-7 signaling", "RAF/MAP kinase cascade", "Interleukin-4 and Interleukin-13 signaling", "Interleukin-20 family signaling", "Interleukin-15 signaling", "Interleukin-15 signaling", "Interleukin-9 signaling", "Interleukin-2 signaling", "Interleukin-21 signaling", "Interleukin receptor SHC signaling"], "372": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "3720": ["PRC2 methylates histones and DNA"], "3725": ["Pre-NOTCH Transcription and Translation", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "FCERI mediated MAPK activation", "Activation of the AP-1 family of transcription factors", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "MAPK6/MAPK4 signaling", "TP53 Regulates Transcription of DNA Repair Genes", "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription", "Estrogen-dependent gene expression"], "3726": ["SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Interleukin-4 and Interleukin-13 signaling"], "3727": ["Estrogen-dependent gene expression"], "3728": ["Adherens junctions interactions", "VEGFR2 mediated vascular permeability", "Neutrophil degranulation", "Keratinization", "Formation of the cornified envelope"], "3730": ["FGFR1c ligand binding and activation", "Negative regulation of FGFR1 signaling"], "373156": ["Glutathione conjugation", "Peroxisomal protein import", "Peroxisomal protein import"], "3735": ["SeMet incorporation into proteins", "Cytosolic tRNA aminoacylation", "Mitochondrial tRNA aminoacylation"], "3736": ["Voltage gated Potassium channels"], "3737": ["Voltage gated Potassium channels"], "3738": ["Voltage gated Potassium channels"], "3739": ["Voltage gated Potassium channels"], "374": ["PIP3 activates AKT signaling", "Signaling by EGFR", "GRB2 events in EGFR signaling", "GAB1 signalosome", "SHC1 events in EGFR signaling", "EGFR downregulation", "COPII-mediated vesicle transport", "EGFR interacts with phospholipase C-gamma", "Constitutive Signaling by Aberrant PI3K in Cancer", "Inhibition of Signaling by Overexpressed EGFR", "RAF/MAP kinase cascade", "Cargo concentration in the ER", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "3741": ["Voltage gated Potassium channels"], "3742": ["Voltage gated Potassium channels"], "374291": ["Respiratory electron transport", "Complex I biogenesis"], "3743": ["Voltage gated Potassium channels"], "374354": ["Platelet degranulation "], "374378": ["O-linked glycosylation of mucins"], "374383": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "374395": ["Neutrophil degranulation"], "3744": ["Voltage gated Potassium channels"], "374403": ["Neutrophil degranulation", "TBC/RABGAPs"], "374454": ["Keratinization", "Formation of the cornified envelope"], "3745": ["Voltage gated Potassium channels", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion"], "374569": ["Amino acid synthesis and interconversion (transamination)"], "3746": ["Voltage gated Potassium channels"], "374654": ["Hedgehog 'off' state", "Hedgehog 'on' state"], "374655": ["Generic Transcription Pathway"], "3747": ["Voltage gated Potassium channels", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion"], "3748": ["Voltage gated Potassium channels"], "374868": ["Ion transport by P-type ATPases"], "374879": ["Generic Transcription Pathway"], "3749": ["Voltage gated Potassium channels"], "374900": ["Generic Transcription Pathway"], "374907": ["O-linked glycosylation of mucins"], "374928": ["Generic Transcription Pathway"], "374986": ["Synthesis of PA"], "375": ["Synthesis of PIPs at the plasma membrane", "Synthesis of PIPs at the Golgi membrane", "Nef Mediated CD4 Down-regulation", "MHC class II antigen presentation", "Clathrin derived vesicle budding", "Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "Intra-Golgi traffic", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "3750": ["Voltage gated Potassium channels", "Phase 1 - inactivation of fast Na+ channels"], "375056": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Cargo concentration in the ER", "Post-translational protein phosphorylation"], "3751": ["Voltage gated Potassium channels", "Phase 1 - inactivation of fast Na+ channels"], "3752": ["Voltage gated Potassium channels", "Phase 1 - inactivation of fast Na+ channels"], "3753": ["Phase 3 - rapid repolarisation", "Phase 2 - plateau phase"], "375318": ["Passive transport by Aquaporins"], "3754": ["Voltage gated Potassium channels"], "3755": ["Voltage gated Potassium channels"], "375519": ["Gap junction assembly"], "3756": ["Voltage gated Potassium channels"], "3757": ["Voltage gated Potassium channels", "Phase 3 - rapid repolarisation"], "375775": ["Glycerophospholipid catabolism"], "375790": ["A tetrasaccharide linker sequence is required for GAG synthesis", "HS-GAG biosynthesis", "HS-GAG biosynthesis", "HS-GAG degradation", "Integrin cell surface interactions", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "ECM proteoglycans", "Defective B4GALT7 causes EDS, progeroid type", "Defective B3GAT3 causes JDSSDHD", "Defective EXT2 causes exostoses 2", "Defective EXT1 causes exostoses 1, TRPS2 and CHDS", "NCAM1 interactions", "Defective B3GALT6 causes EDSP2 and SEMDJL1", "Retinoid metabolism and transport"], "3758": ["Potassium transport channels"], "3759": ["Activation of G protein gated Potassium channels", "Classical Kir channels", "Phase 4 - resting membrane potential", "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "3760": ["Activation of G protein gated Potassium channels", "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "3761": ["Activation of G protein gated Potassium channels", "Classical Kir channels", "Phase 4 - resting membrane potential", "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "3762": ["Activation of G protein gated Potassium channels", "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "376267": ["RAB geranylgeranylation"], "3763": ["Activation of G protein gated Potassium channels", "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "3764": ["ATP sensitive Potassium channels"], "376497": ["PPARA activates gene expression", "Transport of fatty acids"], "3765": ["Activation of G protein gated Potassium channels", "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "3766": ["Activation of G protein gated Potassium channels", "Potassium transport channels", "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "3767": ["ATP sensitive Potassium channels", "ABC-family proteins mediated transport", "Regulation of insulin secretion", "Ion homeostasis", "Defective ABCC8 can cause hypoglycemias and hyperglycemias"], "3768": ["Activation of G protein gated Potassium channels", "Classical Kir channels", "Phase 4 - resting membrane potential", "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "377": ["Synthesis of PIPs at the Golgi membrane", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "3770": ["Classical Kir channels", "Phase 4 - resting membrane potential"], "3772": ["Activation of G protein gated Potassium channels", "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "3772941": ["Toxicity of botulinum toxin type C (BoNT/C)"], "3773": ["Activation of G protein gated Potassium channels", "Potassium transport channels", "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "3775": ["Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)", "Phase 4 - resting membrane potential"], "3776": ["TWIK related potassium channel (TREK)", "Phase 4 - resting membrane potential"], "377630": ["Ub-specific processing proteases"], "377677": ["Reversible hydration of carbon dioxide"], "3777": ["TWIK-releated acid-sensitive K+ channel (TASK)", "Phase 4 - resting membrane potential"], "3778": ["Ca2+ activated K+ channels", "cGMP effects"], "377841": ["Phosphate bond hydrolysis by NTPDase proteins"], "3779": ["Ca2+ activated K+ channels", "cGMP effects"], "378": ["VxPx cargo-targeting to cilium", "VxPx cargo-targeting to cilium", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "3780": ["Ca2+ activated K+ channels"], "3781": ["Ca2+ activated K+ channels"], "3782": ["Ca2+ activated K+ channels"], "3783": ["Ca2+ activated K+ channels"], "3784": ["Voltage gated Potassium channels", "Phase 3 - rapid repolarisation", "Phase 2 - plateau phase"], "3785": ["Voltage gated Potassium channels", "Interaction between L1 and Ankyrins"], "3786": ["Voltage gated Potassium channels", "Interaction between L1 and Ankyrins"], "3787": ["Voltage gated Potassium channels"], "378708": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Deposition of new CENPA-containing nucleosomes at the centromere", "Fanconi Anemia Pathway", "Mitotic Prometaphase"], "3788": ["Voltage gated Potassium channels"], "378807": ["Sperm Motility And Taxes"], "378884": ["Glycogen synthesis", "Myoclonic epilepsy of Lafora"], "3790": ["Voltage gated Potassium channels", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion"], "3791": ["Neurophilin interactions with VEGF and VEGFR", "VEGF binds to VEGFR leading to receptor dimerization", "Integrin cell surface interactions", "VEGFA-VEGFR2 Pathway", "VEGFA-VEGFR2 Pathway", "VEGFR2 mediated cell proliferation"], "3792": ["Peptide ligand-binding receptors"], "3795": ["Essential fructosuria", "Fructose catabolism"], "3796": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "COPI-dependent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "Kinesins"], "3797": ["MHC class II antigen presentation", "Intraflagellar transport", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins", "Kinesins"], "3798": ["MHC class II antigen presentation", "Insulin processing", "RHO GTPases activate KTN1", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "3799": ["MHC class II antigen presentation", "Insulin processing", "RHO GTPases activate KTN1", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "38": ["Branched-chain amino acid catabolism", "Utilization of Ketone Bodies", "Synthesis of Ketone Bodies"], "3800": ["Insulin processing"], "3801": ["Association of TriC/CCT with target proteins during biosynthesis"], "3802": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "3802042": ["Influenza Virus Induced Apoptosis", "Viral mRNA Translation"], "3803": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "3804": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "3805": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "3806": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "DAP12 interactions"], "3809": ["DAP12 interactions"], "381": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "3810": ["DAP12 interactions"], "3811": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "3812": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "3813": ["DAP12 interactions"], "3814": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "3815": ["PIP3 activates AKT signaling", "Signaling by SCF-KIT", "Signaling by SCF-KIT", "Regulation of KIT signaling", "Regulation of KIT signaling", "Constitutive Signaling by Aberrant PI3K in Cancer", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "TFAP2 (AP-2) family regulates transcription of growth factors and their receptors"], "3816": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "3817": ["Activation of Matrix Metalloproteinases", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3"], "3818": ["Intrinsic Pathway of Fibrin Clot Formation", "Activation of Matrix Metalloproteinases"], "382": ["TBC/RABGAPs", "Clathrin-mediated endocytosis", "MET receptor recycling"], "3820": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "3821": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "3822": ["DAP12 interactions", "DAP12 signaling", "DAP12 signaling"], "3824": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "DAP12 interactions", "DAP12 signaling", "DAP12 signaling"], "3827": ["Platelet degranulation ", "Intrinsic Pathway of Fibrin Clot Formation", "Peptide ligand-binding receptors", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "G alpha (q) signalling events", "G alpha (i) signalling events", "Post-translational protein phosphorylation"], "383": ["Neutrophil degranulation", "Urea cycle"], "3831": ["MHC class II antigen presentation", "RHO GTPases activate KTN1", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "3832": ["MHC class II antigen presentation", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "3833": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins", "Kinesins"], "3834": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "3835": ["MHC class II antigen presentation", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "3836": ["ISG15 antiviral mechanism", "Integration of provirus", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Vpr-mediated nuclear import of PICs", "Activation of DNA fragmentation factor"], "3837": ["ISG15 antiviral mechanism", "Regulation of cholesterol biosynthesis by SREBP (SREBF)", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Nuclear import of Rev protein", "Nuclear import of Rev protein", "Activation of DNA fragmentation factor", "Neutrophil degranulation"], "3838": ["CaMK IV-mediated phosphorylation of CREB", "ISG15 antiviral mechanism", "NS1 Mediated Effects on Host Pathways", "CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "Sensing of DNA Double Strand Breaks", "Estrogen-dependent gene expression"], "3839": ["ISG15 antiviral mechanism", "NS1 Mediated Effects on Host Pathways"], "384": ["Urea cycle"], "3840": ["ISG15 antiviral mechanism", "NS1 Mediated Effects on Host Pathways"], "3841": ["ISG15 antiviral mechanism", "NS1 Mediated Effects on Host Pathways"], "3842": ["Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "Intraflagellar transport"], "3843": ["vRNP Assembly"], "3845": ["SOS-mediated signalling", "Activation of RAS in B cells", "Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "SHC1 events in ERBB2 signaling", "SHC1 events in ERBB4 signaling", "Signaling by SCF-KIT", "Signalling to RAS", "p38MAPK events", "p38MAPK events", "GRB2 events in EGFR signaling", "SHC1 events in EGFR signaling", "Downstream signal transduction", "GRB2 events in ERBB2 signaling", "GRB2 events in ERBB2 signaling", "Tie2 Signaling", "EGFR Transactivation by Gastrin", "DAP12 signaling", "SHC-related events triggered by IGF1R", "FCERI mediated MAPK activation", "NCAM signaling for neurite out-growth", "Ras activation upon Ca2+ influx through NMDA receptor", "VEGFR2 mediated cell proliferation", "CD209 (DC-SIGN) signaling", "Constitutive Signaling by EGFRvIII", "SHC-mediated cascade:FGFR1", "FRS-mediated FGFR1 signaling", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "Signaling by FGFR2 in disease", "Signaling by FGFR4 in disease", "Signaling by FGFR1 in disease", "Regulation of RAS by GAPs", "RAF activation", "RAF/MAP kinase cascade", "MAP2K and MAPK activation", "Negative regulation of MAPK pathway", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "RAS signaling downstream of NF1 loss-of-function variants", "Paradoxical activation of RAF signaling by kinase inactive BRAF", "Insulin receptor signalling cascade", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "MET activates RAS signaling", "Signaling by FGFR3 fusions in cancer", "Signaling by FGFR3 point mutants in cancer", "RUNX3 regulates p14-ARF", "Activated NTRK2 signals through RAS", "Erythropoietin activates RAS", "Activated NTRK2 signals through FRS2 and FRS3", "Activated NTRK3 signals through RAS"], "3846": ["Keratinization"], "3848": ["Neutrophil degranulation", "Keratinization", "Formation of the cornified envelope"], "3849": ["Keratinization", "Formation of the cornified envelope"], "3850": ["Keratinization", "Formation of the cornified envelope"], "3852": ["Type I hemidesmosome assembly", "Keratinization", "Formation of the cornified envelope"], "3853": ["Keratinization", "Formation of the cornified envelope"], "3854": ["Keratinization", "Formation of the cornified envelope"], "3855": ["Keratinization", "Formation of the cornified envelope"], "3856": ["Keratinization", "Formation of the cornified envelope"], "3857": ["Keratinization", "Formation of the cornified envelope"], "3858": ["Keratinization", "Formation of the cornified envelope"], "3859": ["Keratinization", "Formation of the cornified envelope"], "3860": ["Keratinization", "Formation of the cornified envelope"], "3861": ["Type I hemidesmosome assembly", "Keratinization", "Formation of the cornified envelope"], "3866": ["Keratinization", "Formation of the cornified envelope"], "386653": ["IL-6-type cytokine receptor ligand interactions"], "386674": ["Keratinization"], "386675": ["Keratinization"], "386676": ["Keratinization"], "386677": ["Keratinization"], "386678": ["Keratinization"], "386679": ["Keratinization"], "386681": ["Keratinization"], "386682": ["Keratinization"], "386683": ["Keratinization"], "386684": ["Keratinization"], "386685": ["Keratinization"], "3868": ["Keratinization", "Formation of the cornified envelope"], "387": ["GPVI-mediated activation cascade", "Axonal growth inhibition (RHOA activation)", "Rho GTPase cycle", "PI3K/AKT activation", "Axonal growth stimulation", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "G beta:gamma signalling through PI3Kgamma", "EPHB-mediated forward signaling", "EPHB-mediated forward signaling", "EPHA-mediated growth cone collapse", "EPHA-mediated growth cone collapse", "PCP/CE pathway", "G alpha (12/13) signalling events", "Sema4D mediated inhibition of cell attachment and migration", "Sema4D induced cell migration and growth-cone collapse", "Sema4D induced cell migration and growth-cone collapse", "VEGFA-VEGFR2 Pathway", "RHO GTPases activate PKNs", "RHO GTPases activate CIT", "RHO GTPases activate CIT", "RHO GTPases activate KTN1", "RHO GTPases Activate ROCKs", "RHO GTPases Activate ROCKs", "RHO GTPases Activate Formins", "RHO GTPases Activate Rhotekin and Rhophilins", "RHO GTPases Activate Rhotekin and Rhophilins", "Ovarian tumor domain proteases", "ERBB2 Regulates Cell Motility", "Neutrophil degranulation", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "SLIT2:ROBO1 increases RHOA activity"], "387032": ["Generic Transcription Pathway"], "387103": ["Deposition of new CENPA-containing nucleosomes at the centromere"], "387129": ["Peptide ligand-binding receptors", "G alpha (q) signalling events", "G alpha (s) signalling events"], "3872": ["Keratinization", "Formation of the cornified envelope"], "387263": ["Neutrophil degranulation"], "387264": ["Keratinization"], "387266": ["Keratinization"], "387267": ["Keratinization"], "387273": ["Keratinization"], "387338": ["rRNA modification in the mitochondrion"], "3875": ["Keratinization", "Formation of the cornified envelope"], "387522": ["NOD1/2 Signaling Pathway", "TICAM1, RIP1-mediated IKK complex recruitment ", "Downstream TCR signaling", "FCERI mediated NF-kB activation", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "activated TAK1 mediates p38 MAPK activation", "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "CLEC7A (Dectin-1) signaling", "Interleukin-1 signaling", "IRAK1 recruits IKK complex", "IKK complex recruitment mediated by RIP1", "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "Antigen processing: Ubiquitination & Proteasome degradation"], "387748": ["Olfactory Signaling Pathway"], "387787": ["Glyoxylate metabolism and glycine degradation"], "387893": ["Condensation of Prophase Chromosomes", "PKMTs methylate histone lysines", "Regulation of TP53 Activity through Methylation"], "387921": ["Neutrophil degranulation"], "388": ["GPVI-mediated activation cascade", "Rho GTPase cycle", "G alpha (12/13) signalling events", "Sema4D induced cell migration and growth-cone collapse", "Sema4D induced cell migration and growth-cone collapse", "RHO GTPases activate PKNs", "RHO GTPases activate CIT", "RHO GTPases activate CIT", "RHO GTPases Activate ROCKs", "RHO GTPases Activate ROCKs", "RHO GTPases Activate Formins", "RHO GTPases Activate Rhotekin and Rhophilins"], "3880": ["Keratinization", "Formation of the cornified envelope"], "3881": ["Keratinization", "Formation of the cornified envelope"], "388121": ["PI Metabolism"], "3882": ["Keratinization", "Formation of the cornified envelope"], "3883": ["Keratinization", "Formation of the cornified envelope"], "388372": ["G alpha (i) signalling events", "Interleukin-10 signaling"], "3884": ["Keratinization", "Formation of the cornified envelope"], "3885": ["Keratinization", "Formation of the cornified envelope"], "388531": ["Inactivation, recovery and regulation of the phototransduction cascade", "Inactivation, recovery and regulation of the phototransduction cascade"], "388536": ["Generic Transcription Pathway"], "388552": ["Golgi Associated Vesicle Biogenesis"], "388561": ["Generic Transcription Pathway"], "388566": ["Generic Transcription Pathway"], "388567": ["Generic Transcription Pathway"], "388569": ["Generic Transcription Pathway"], "388585": ["NOTCH1 Intracellular Domain Regulates Transcription", "NOTCH2 intracellular domain regulates transcription", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "NOTCH3 Intracellular Domain Regulates Transcription", "NOTCH4 Intracellular Domain Regulates Transcription"], "3886": ["Keratinization", "Formation of the cornified envelope"], "388646": ["Interferon gamma signaling"], "388697": ["Neutrophil degranulation"], "388698": ["Neutrophil degranulation"], "3887": ["Keratinization", "Formation of the cornified envelope"], "388743": ["Degradation of the extracellular matrix"], "388753": ["Mitochondrial protein import"], "3888": ["Keratinization", "Formation of the cornified envelope"], "388818": ["Keratinization"], "3889": ["Keratinization", "Formation of the cornified envelope"], "389": ["Rho GTPase cycle", "G alpha (12/13) signalling events", "Sema4D induced cell migration and growth-cone collapse", "Sema4D induced cell migration and growth-cone collapse", "RHO GTPases activate PKNs", "RHO GTPases activate CIT", "RHO GTPases activate CIT", "RHO GTPases Activate ROCKs", "RHO GTPases Activate ROCKs", "RHO GTPases Activate Formins", "RHO GTPases Activate Rhotekin and Rhophilins"], "3890": ["Keratinization", "Formation of the cornified envelope"], "389015": ["Sodium/Proton exchangers"], "389090": ["Olfactory Signaling Pathway"], "3891": ["Keratinization", "Formation of the cornified envelope"], "389114": ["Generic Transcription Pathway"], "3892": ["Keratinization", "Formation of the cornified envelope"], "389337": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "389396": ["Conjugation of salicylate with glycine", "Conjugation of benzoate with glycine"], "389434": ["Thyroxine biosynthesis"], "3895": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "RHO GTPases activate KTN1", "Post-translational protein phosphorylation"], "389541": ["Macroautophagy", "mTOR signalling", "mTORC1-mediated signalling", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Regulation of PTEN gene transcription"], "389692": ["Regulation of gene expression in beta cells"], "3897": ["Basigin interactions", "L1CAM interactions", "L1CAM interactions", "Recycling pathway of L1", "Recycling pathway of L1", "Interaction between L1 and Ankyrins", "Interaction between L1 and Ankyrins", "Signal transduction by L1"], "389812": ["Transport of fatty acids"], "39": ["Cholesterol biosynthesis"], "390036": ["Olfactory Signaling Pathway"], "390037": ["Olfactory Signaling Pathway"], "390038": ["Olfactory Signaling Pathway"], "390054": ["Olfactory Signaling Pathway"], "390058": ["Olfactory Signaling Pathway"], "390059": ["Olfactory Signaling Pathway"], "390061": ["Olfactory Signaling Pathway"], "390063": ["Olfactory Signaling Pathway"], "390064": ["Olfactory Signaling Pathway"], "390066": ["Olfactory Signaling Pathway"], "390067": ["Olfactory Signaling Pathway"], "390072": ["Olfactory Signaling Pathway"], "390075": ["Olfactory Signaling Pathway"], "390077": ["Olfactory Signaling Pathway"], "390078": ["Olfactory Signaling Pathway"], "390079": ["Olfactory Signaling Pathway"], "390081": ["Olfactory Signaling Pathway"], "390083": ["Olfactory Signaling Pathway"], "390084": ["Olfactory Signaling Pathway"], "390093": ["Olfactory Signaling Pathway"], "390113": ["Olfactory Signaling Pathway"], "390142": ["Olfactory Signaling Pathway"], "390144": ["Olfactory Signaling Pathway"], "390148": ["Olfactory Signaling Pathway"], "390151": ["Olfactory Signaling Pathway"], "390152": ["Olfactory Signaling Pathway"], "390154": ["Olfactory Signaling Pathway"], "390155": ["Olfactory Signaling Pathway"], "390157": ["Olfactory Signaling Pathway"], "390162": ["Olfactory Signaling Pathway"], "390167": ["Olfactory Signaling Pathway"], "390168": ["Olfactory Signaling Pathway"], "390174": ["Olfactory Signaling Pathway"], "390181": ["Olfactory Signaling Pathway"], "390190": ["Olfactory Signaling Pathway"], "390191": ["Olfactory Signaling Pathway"], "390195": ["Olfactory Signaling Pathway"], "390197": ["Olfactory Signaling Pathway"], "390199": ["Olfactory Signaling Pathway"], "3902": ["MHC class II antigen presentation"], "390201": ["Olfactory Signaling Pathway"], "390243": ["Post-translational modification: synthesis of GPI-anchored proteins"], "390260": ["Olfactory Signaling Pathway"], "390261": ["Olfactory Signaling Pathway"], "390264": ["Olfactory Signaling Pathway"], "390265": ["Olfactory Signaling Pathway"], "390271": ["Olfactory Signaling Pathway"], "390275": ["Olfactory Signaling Pathway"], "3903": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation"], "390321": ["Olfactory Signaling Pathway"], "390323": ["Olfactory Signaling Pathway"], "390326": ["Olfactory Signaling Pathway"], "390327": ["Olfactory Signaling Pathway"], "3904": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "390429": ["Olfactory Signaling Pathway"], "390431": ["Olfactory Signaling Pathway"], "390433": ["Olfactory Signaling Pathway"], "390436": ["Olfactory Signaling Pathway"], "390437": ["Olfactory Signaling Pathway"], "390439": ["Olfactory Signaling Pathway"], "390441": ["Olfactory Signaling Pathway"], "390442": ["Olfactory Signaling Pathway"], "390445": ["Olfactory Signaling Pathway"], "390538": ["Olfactory Signaling Pathway"], "390594": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "3906": ["Lactose synthesis"], "390648": ["Olfactory Signaling Pathway"], "390649": ["Olfactory Signaling Pathway"], "390792": ["Keratinization", "Formation of the cornified envelope"], "3908": ["Laminin interactions", "Laminin interactions", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "MET activates PTK2 signaling"], "390874": ["Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "Regulation of gene expression in early pancreatic precursor cells"], "390882": ["Olfactory Signaling Pathway"], "390883": ["Olfactory Signaling Pathway"], "390892": ["Olfactory Signaling Pathway"], "3909": ["Degradation of the extracellular matrix", "Degradation of the extracellular matrix", "Assembly of collagen fibrils and other multimeric structures", "Anchoring fibril formation", "Laminin interactions", "Laminin interactions", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "Type I hemidesmosome assembly", "MET activates PTK2 signaling"], "390916": ["Peroxisomal lipid metabolism", "Peroxisomal protein import", "Peroxisomal protein import"], "390927": ["Generic Transcription Pathway"], "391": ["GPVI-mediated activation cascade", "PIP3 activates AKT signaling", "Rho GTPase cycle", "Constitutive Signaling by Aberrant PI3K in Cancer", "RHO GTPases activate KTN1", "Neutrophil degranulation", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "3910": ["Laminin interactions", "Laminin interactions", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "MET activates PTK2 signaling"], "3911": ["Degradation of the extracellular matrix", "Laminin interactions", "Laminin interactions", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "Interleukin-4 and Interleukin-13 signaling", "MET activates PTK2 signaling"], "391107": ["Olfactory Signaling Pathway"], "391109": ["Olfactory Signaling Pathway"], "391112": ["Olfactory Signaling Pathway"], "391114": ["Olfactory Signaling Pathway"], "391189": ["Olfactory Signaling Pathway"], "391190": ["Olfactory Signaling Pathway"], "391191": ["Olfactory Signaling Pathway"], "391192": ["Olfactory Signaling Pathway"], "391194": ["Olfactory Signaling Pathway"], "391195": ["Olfactory Signaling Pathway"], "391196": ["Olfactory Signaling Pathway"], "3912": ["Degradation of the extracellular matrix", "Laminin interactions", "Laminin interactions", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "L1CAM interactions", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "MET activates PTK2 signaling", "Post-translational protein phosphorylation"], "391211": ["Olfactory Signaling Pathway"], "3913": ["Laminin interactions", "Laminin interactions", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "MET activates PTK2 signaling", "Post-translational protein phosphorylation"], "391365": ["Cytosolic sulfonation of small molecules"], "3914": ["Degradation of the extracellular matrix", "Degradation of the extracellular matrix", "Assembly of collagen fibrils and other multimeric structures", "Anchoring fibril formation", "Laminin interactions", "Laminin interactions", "Non-integrin membrane-ECM interactions", "Type I hemidesmosome assembly", "MET activates PTK2 signaling"], "3915": ["Degradation of the extracellular matrix", "Laminin interactions", "Laminin interactions", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "L1CAM interactions", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "MET activates PTK2 signaling", "Post-translational protein phosphorylation"], "3916": ["Neutrophil degranulation"], "3918": ["Degradation of the extracellular matrix", "Degradation of the extracellular matrix", "Assembly of collagen fibrils and other multimeric structures", "Anchoring fibril formation", "Laminin interactions", "Laminin interactions", "Non-integrin membrane-ECM interactions", "Type I hemidesmosome assembly", "MET activates PTK2 signaling"], "392": ["Rho GTPase cycle"], "3920": ["Platelet degranulation ", "Neutrophil degranulation"], "3921": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "392138": ["Olfactory Signaling Pathway"], "392188": ["Ub-specific processing proteases"], "392309": ["Olfactory Signaling Pathway"], "392376": ["Olfactory Signaling Pathway"], "392390": ["Olfactory Signaling Pathway"], "392391": ["Olfactory Signaling Pathway"], "392392": ["Olfactory Signaling Pathway"], "392399": ["Transport of fatty acids"], "392636": ["Triglyceride biosynthesis"], "3929": ["Toll Like Receptor 4 (TLR4) Cascade", "Transfer of LPS from LBP carrier to CD14", "Regulation of TLR by endogenous ligand", "Interleukin-4 and Interleukin-13 signaling"], "393": ["Rho GTPase cycle"], "3930": ["Cholesterol biosynthesis", "Regulation of MECP2 expression and activity"], "393046": ["Olfactory Signaling Pathway"], "3931": ["HDL remodeling"], "3932": ["GPVI-mediated activation cascade", "PIP3 activates AKT signaling", "Signaling by SCF-KIT", "Signaling by SCF-KIT", "Regulation of KIT signaling", "Nef and signal transduction", "Nef Mediated CD4 Down-regulation", "Downstream TCR signaling", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "PECAM1 interactions", "Constitutive Signaling by Aberrant PI3K in Cancer", "DAP12 signaling", "DAP12 signaling", "CD28 co-stimulation", "CD28 dependent PI3K/Akt signaling", "CD28 dependent Vav1 pathway", "CTLA4 inhibitory signaling", "PD-1 signaling", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Interleukin-2 signaling"], "3933": ["Transport of fatty acids"], "3934": ["Interleukin-4 and Interleukin-13 signaling", "Neutrophil degranulation", "Metal sequestration by antimicrobial proteins", "Iron uptake and transport", "Iron uptake and transport"], "3936": ["Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "3937": ["GPVI-mediated activation cascade", "Generation of second messenger molecules", "Generation of second messenger molecules", "DAP12 signaling", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization"], "3938": ["Digestion of dietary carbohydrate", "Intestinal saccharidase deficiencies"], "3939": ["Pyruvate metabolism"], "394": ["Rho GTPase cycle"], "394263": ["Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)", "Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)", "Defective GALNT12 causes colorectal cancer 1 (CRCS1)", "Dectin-2 family", "O-linked glycosylation of mucins", "Termination of O-glycan biosynthesis"], "3945": ["Pyruvate metabolism"], "3948": ["Pyruvate metabolism"], "3949": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "Chylomicron clearance", "Chylomicron clearance", "LDL clearance", "Retinoid metabolism and transport"], "395": ["Rho GTPase cycle"], "3952": ["Signaling by Leptin", "Transcriptional regulation of white adipocyte differentiation", "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "Synthesis, secretion, and deacylation of Ghrelin"], "3953": ["Signaling by Leptin"], "3954": ["Mitochondrial calcium ion transport"], "3955": ["Pre-NOTCH Processing in Golgi", "Defective LFNG causes SCDO3"], "3956": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "3958": ["Neutrophil degranulation", "Advanced glycosylation endproduct receptor signaling", "RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "RUNX2 regulates genes involved in differentiation of myeloid cells"], "3959": ["Platelet degranulation "], "396": ["Axonal growth inhibition (RHOA activation)", "Rho GTPase cycle", "Axonal growth stimulation"], "3965": ["Interleukin-2 family signaling"], "397": ["Rho GTPase cycle"], "3972": ["Androgen biosynthesis", "Mineralocorticoid biosynthesis", "Glycoprotein hormones", "Hormone ligand-binding receptors", "G alpha (s) signalling events", "Reactions specific to the complex N-glycan synthesis pathway"], "3973": ["Hormone ligand-binding receptors", "G alpha (s) signalling events"], "3976": ["Interleukin-10 signaling", "Interleukin-4 and Interleukin-13 signaling", "IL-6-type cytokine receptor ligand interactions"], "3977": ["IL-6-type cytokine receptor ligand interactions", "RUNX1 regulates transcription of genes involved in interleukin signaling"], "3978": ["POLB-Dependent Long Patch Base Excision Repair", "Early Phase of HIV Life Cycle", "Processive synthesis on the C-strand of the telomere", "Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "PCNA-Dependent Long Patch Base Excision Repair", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Processive synthesis on the lagging strand"], "398": ["Rho GTPase cycle"], "3980": ["Resolution of AP sites via the single-nucleotide replacement pathway", "APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "HDR through MMEJ (alt-NHEJ)", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER"], "3981": ["2-LTR circle formation", "Nonhomologous End-Joining (NHEJ)"], "3983": ["DCC mediated attractive signaling"], "3984": ["Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "EPHB-mediated forward signaling", "Sema3A PAK dependent Axon repulsion", "Sema3A PAK dependent Axon repulsion", "Sema4D induced cell migration and growth-cone collapse", "RHO GTPases Activate ROCKs", "RHO GTPases activate PAKs"], "3985": ["EPHB-mediated forward signaling", "Sema4D induced cell migration and growth-cone collapse", "RHO GTPases Activate ROCKs"], "3987": ["Cell-extracellular matrix interactions", "Regulation of cytoskeletal remodeling and cell spreading by IPP complex components"], "3988": ["LDL clearance"], "399": ["Rho GTPase cycle"], "3990": ["Assembly of active LPL and LIPC lipase complexes", "Chylomicron clearance"], "3991": ["Triglyceride catabolism"], "3992": ["PPARA activates gene expression", "Linoleic acid (LA) metabolism", "alpha-linolenic acid (ALA) metabolism"], "399473": ["Regulation of RAS by GAPs", "Signaling by RAS mutants"], "399687": ["Signaling by cytosolic FGFR1 fusion mutants", "Signaling by FGFR1 in disease"], "3998": ["COPII-mediated vesicle transport", "Cargo concentration in the ER", "Transport to the Golgi and subsequent modification"], "399818": ["Protein methylation"], "40": ["Stimuli-sensing channels"], "400": ["Retrograde transport at the Trans-Golgi-Network"], "4000": ["Meiotic synapsis", "Clearance of Nuclear Envelope Membranes from Chromatin", "Initiation of Nuclear Envelope Reformation", "Breakdown of the nuclear lamina", "XBP1(S) activates chaperone genes", "Depolymerisation of the Nuclear Lamina", "Signaling by BRAF and RAF fusions", "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models"], "4001": ["Meiotic synapsis", "Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "Clearance of Nuclear Envelope Membranes from Chromatin", "Initiation of Nuclear Envelope Reformation", "Breakdown of the nuclear lamina", "Depolymerisation of the Nuclear Lamina", "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "4004": ["RUNX1 regulates transcription of genes involved in differentiation of HSCs"], "4005": ["RUNX1 regulates transcription of genes involved in differentiation of HSCs"], "400569": ["PPARA activates gene expression", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "400720": ["Generic Transcription Pathway"], "4008": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "400830": ["Beta defensins", "Defensins"], "400916": ["Mitochondrial protein import"], "401036": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "401138": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "4012": ["Endosomal/Vacuolar pathway", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Antigen processing: Ubiquitination & Proteasome degradation"], "401258": ["Neutrophil degranulation", "RAB geranylgeranylation"], "4014": ["Formation of the cornified envelope"], "401409": ["RAB geranylgeranylation"], "401427": ["Olfactory Signaling Pathway"], "401447": ["Ub-specific processing proteases"], "401494": ["Synthesis of very long-chain fatty acyl-CoAs"], "4015": ["Elastic fibre formation", "Crosslinking of collagen fibrils"], "401505": ["Mitochondrial protein import", "Pink/Parkin Mediated Mitophagy"], "401541": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Deposition of new CENPA-containing nucleosomes at the centromere", "Mitotic Prometaphase"], "4016": ["Elastic fibre formation", "Crosslinking of collagen fibrils"], "401663": ["Olfactory Signaling Pathway"], "401665": ["Olfactory Signaling Pathway"], "401666": ["Olfactory Signaling Pathway"], "401667": ["Olfactory Signaling Pathway"], "4017": ["Elastic fibre formation", "Crosslinking of collagen fibrils"], "401992": ["Olfactory Signaling Pathway"], "401993": ["Olfactory Signaling Pathway"], "401994": ["Olfactory Signaling Pathway"], "402": ["Post-chaperonin tubulin folding pathway", "Regulation of insulin secretion"], "402135": ["Olfactory Signaling Pathway"], "4023": ["Transcriptional regulation of white adipocyte differentiation", "Assembly of active LPL and LIPC lipase complexes", "Chylomicron remodeling", "Retinoid metabolism and transport"], "402317": ["Olfactory Signaling Pathway"], "4025": ["Events associated with phagocytolytic activity of PMN cells"], "402569": ["ISG15 antiviral mechanism", "NS1 Mediated Effects on Host Pathways"], "403": ["Trafficking of myristoylated proteins to the cilium"], "403239": ["Olfactory Signaling Pathway"], "403244": ["Olfactory Signaling Pathway"], "403253": ["Olfactory Signaling Pathway"], "403273": ["Olfactory Signaling Pathway"], "403274": ["Olfactory Signaling Pathway"], "403277": ["Olfactory Signaling Pathway"], "403278": ["Olfactory Signaling Pathway"], "403282": ["Olfactory Signaling Pathway"], "403284": ["Olfactory Signaling Pathway"], "4033": ["Neutrophil degranulation"], "403313": ["Cholesterol biosynthesis"], "403314": ["mRNA Editing: C to U Conversion", "Formation of the Editosome"], "403339": ["Beta defensins", "Defensins"], "4035": ["Scavenging of heme from plasma", "Retinoid metabolism and transport"], "4036": ["Vitamin D (calciferol) metabolism", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "Retinoid metabolism and transport"], "4038": ["ECM proteoglycans"], "4040": ["TCF dependent signaling in response to WNT", "Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Regulation of FZD by ubiquitination", "RNF mutants show enhanced WNT signaling and proliferation"], "4041": ["TCF dependent signaling in response to WNT", "Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Regulation of FZD by ubiquitination", "Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling", "RNF mutants show enhanced WNT signaling and proliferation"], "404203": ["Formation of the cornified envelope"], "4045": ["Post-translational modification: synthesis of GPI-anchored proteins"], "404672": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Tat-mediated elongation of the HIV-1 transcript", "NoRC negatively regulates rRNA expression", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "mRNA Capping", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase I Transcription Termination", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE"], "4047": ["Cholesterol biosynthesis", "Activation of gene expression by SREBF (SREBP)"], "4048": ["Synthesis of Leukotrienes (LT) and Eoxins (EX)", "Neutrophil degranulation", "Biosynthesis of D-series resolvins", "Biosynthesis of protectins", "Biosynthesis of E-series 18(S)-resolvins", "Biosynthesis of aspirin-triggered D-series resolvins", "Biosynthesis of E-series 18(R)-resolvins"], "4049": ["TNFR2 non-canonical NF-kB pathway", "TNFs bind their physiological receptors", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "405": ["Regulation of gene expression by Hypoxia-inducible Factor", "PPARA activates gene expression", "Phase I - Functionalization of compounds", "Endogenous sterols", "Xenobiotics", "Aryl hydrocarbon receptor signalling"], "4050": ["TNFR2 non-canonical NF-kB pathway", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "4051": ["Fatty acids", "Miscellaneous substrates", "Eicosanoids", "Synthesis of Leukotrienes (LT) and Eoxins (EX)"], "4052": ["Molecules associated with elastic fibres", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "4053": ["Molecules associated with elastic fibres"], "4054": ["Molecules associated with elastic fibres"], "4055": ["TNFR2 non-canonical NF-kB pathway", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "4056": ["Synthesis of 5-eicosatetraenoic acids", "Synthesis of Leukotrienes (LT) and Eoxins (EX)", "Synthesis of Lipoxins (LX)", "Biosynthesis of maresin conjugates in tissue regeneration (MCTR)", "Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR)"], "4057": ["Mtb iron assimilation by chelation", "Neutrophil degranulation", "Metal sequestration by antimicrobial proteins", "Antimicrobial peptides", "Amyloid fiber formation"], "406": ["BMAL1:CLOCK,NPAS2 activates circadian gene expression", "BMAL1:CLOCK,NPAS2 activates circadian gene expression", "PPARA activates gene expression", "Circadian Clock"], "4060": ["Keratan sulfate biosynthesis", "Keratan sulfate degradation", "Integrin cell surface interactions", "ECM proteoglycans", "Defective CHST6 causes MCDC1", "Defective ST3GAL3 causes MCT12 and EIEE15", "Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)"], "4061": ["Post-translational modification: synthesis of GPI-anchored proteins"], "4062": ["Post-translational modification: synthesis of GPI-anchored proteins"], "4064": ["Toll Like Receptor 4 (TLR4) Cascade"], "4067": ["GPVI-mediated activation cascade", "Signaling by SCF-KIT", "Signaling by SCF-KIT", "Regulation of KIT signaling", "Cell surface interactions at the vascular wall", "FCGR activation", "PECAM1 interactions", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "EPH-Ephrin signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD28 co-stimulation", "CTLA4 inhibitory signaling", "EPHB-mediated forward signaling", "EPHB-mediated forward signaling", "EPHA-mediated growth cone collapse", "EPHA-mediated growth cone collapse", "EPH-ephrin mediated repulsion of cells", "Dectin-2 family", "CD209 (DC-SIGN) signaling", "CD22 mediated BCR regulation", "Cyclin D associated events in G1", "Platelet Adhesion to exposed collagen", "Signaling by Erythropoietin", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "Erythropoietin activates Phospholipase C gamma (PLCG)", "Erythropoietin activates STAT5", "Erythropoietin activates RAS", "Erythropoietin activates RAS", "Regulation of signaling by CBL", "Regulation of signaling by CBL", "Growth hormone receptor signaling", "Growth hormone receptor signaling", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "4068": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "4069": ["Neutrophil degranulation", "Antimicrobial peptides", "Amyloid fiber formation"], "4072": ["Cell surface interactions at the vascular wall"], "4074": ["Lysosome Vesicle Biogenesis", "Retrograde transport at the Trans-Golgi-Network", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "407977": ["TNFR2 non-canonical NF-kB pathway", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "408": ["Activated NOTCH1 Transmits Signal to the Nucleus", "G alpha (s) signalling events", "Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis", "Thrombin signalling through proteinase activated receptors (PARs)", "Activation of SMO", "Activation of SMO", "MAP2K and MAPK activation", "Ub-specific processing proteases", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "4082": ["Acetylcholine regulates insulin secretion"], "4085": ["Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components", "Inactivation of APC/C via direct inhibition of the APC/C complex", "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "APC/C:Cdc20 mediated degradation of mitotic proteins", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "4086": ["Signaling by BMP", "Ub-specific processing proteases", "RUNX2 regulates bone development"], "4087": ["Signaling by NODAL", "Signaling by NODAL", "Signaling by Activin", "Downregulation of TGF-beta receptor signaling", "TGF-beta receptor signaling activates SMADs", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "SMAD2/3 Phosphorylation Motif Mutants in Cancer", "SMAD4 MH2 Domain Mutants in Cancer", "SMAD2/3 MH2 Domain Mutants in Cancer", "TGFBR1 KD Mutants in Cancer", "Transcriptional regulation of pluripotent stem cells", "Ub-specific processing proteases", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "FOXO-mediated transcription of cell cycle genes", "FOXO-mediated transcription of cell cycle genes"], "4088": ["Signaling by NODAL", "Signaling by NODAL", "Signaling by Activin", "Downregulation of TGF-beta receptor signaling", "TGF-beta receptor signaling activates SMADs", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "SMAD2/3 Phosphorylation Motif Mutants in Cancer", "SMAD4 MH2 Domain Mutants in Cancer", "SMAD2/3 MH2 Domain Mutants in Cancer", "TGFBR1 KD Mutants in Cancer", "Ub-specific processing proteases", "RUNX3 regulates CDKN1A transcription", "RUNX3 regulates BCL2L11 (BIM) transcription", "Interleukin-37 signaling", "NOTCH4 Intracellular Domain Regulates Transcription", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "FOXO-mediated transcription of cell cycle genes", "FOXO-mediated transcription of cell cycle genes"], "4089": ["Signaling by NODAL", "Signaling by Activin", "Signaling by BMP", "TGF-beta receptor signaling activates SMADs", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "SMAD4 MH2 Domain Mutants in Cancer", "SMAD2/3 MH2 Domain Mutants in Cancer", "Transcriptional regulation of pluripotent stem cells", "Ub-specific processing proteases", "RUNX2 regulates bone development", "RUNX3 regulates CDKN1A transcription", "RUNX3 regulates BCL2L11 (BIM) transcription", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "FOXO-mediated transcription of cell cycle genes", "FOXO-mediated transcription of cell cycle genes"], "409": ["Activated NOTCH1 Transmits Signal to the Nucleus", "G alpha (s) signalling events", "Thrombin signalling through proteinase activated receptors (PARs)", "WNT5A-dependent internalization of FZD4", "Activation of SMO", "Activation of SMO", "MAP2K and MAPK activation", "Ub-specific processing proteases", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "4090": ["Signaling by BMP"], "4091": ["Signaling by BMP", "RUNX2 regulates bone development"], "4092": ["Signaling by BMP", "Downregulation of TGF-beta receptor signaling", "Downregulation of TGF-beta receptor signaling", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "UCH proteinases", "Ub-specific processing proteases"], "4093": ["Signaling by BMP"], "4094": ["RUNX2 regulates osteoblast differentiation"], "4097": ["Factors involved in megakaryocyte development and platelet production", "Factors involved in megakaryocyte development and platelet production"], "4099": ["Axonal growth inhibition (RHOA activation)", "Basigin interactions"], "41": ["Stimuli-sensing channels"], "410": ["Glycosphingolipid metabolism", "The activation of arylsulfatases", "Neutrophil degranulation"], "411": ["Glycosphingolipid metabolism", "The activation of arylsulfatases", "CS/DS degradation", "MPS VI - Maroteaux-Lamy syndrome", "Neutrophil degranulation"], "4116": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "412": ["Glycosphingolipid metabolism", "The activation of arylsulfatases"], "4121": ["Intra-Golgi traffic", "Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2"], "4122": ["Intra-Golgi traffic", "Reactions specific to the complex N-glycan synthesis pathway"], "4123": ["Lysosomal oligosaccharide catabolism"], "4124": ["Intra-Golgi traffic", "Reactions specific to the complex N-glycan synthesis pathway"], "4125": ["Neutrophil degranulation", "Lysosomal oligosaccharide catabolism"], "4126": ["Neutrophil degranulation", "Lysosomal oligosaccharide catabolism"], "4128": ["Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB", "Norepinephrine Neurotransmitter Release Cycle", "Enzymatic degradation of dopamine by COMT", "Enzymatic degradation of Dopamine by monoamine oxidase", "Metabolism of serotonin", "Defective MAOA causes Brunner syndrome (BRUNS)", "Interleukin-4 and Interleukin-13 signaling"], "4129": ["Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB"], "4137": ["Caspase-mediated cleavage of cytoskeletal proteins", "Activation of AMPK downstream of NMDARs"], "414": ["Glycosphingolipid metabolism", "The activation of arylsulfatases"], "4140": ["RAF activation", "MAP2K and MAPK activation", "Negative regulation of MAPK pathway", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF"], "414060": ["TBC/RABGAPs"], "414062": ["Interleukin-10 signaling"], "4141": ["SeMet incorporation into proteins", "Cytosolic tRNA aminoacylation"], "414149": ["Mitochondrial Fatty Acid Beta-Oxidation"], "4143": ["Methylation", "Sulfur amino acid metabolism", "Metabolism of ingested SeMet, Sec, MeSec into H2Se", "Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD)"], "414325": ["Beta defensins", "Defensins"], "4144": ["Methylation"], "4145": ["Downregulation of ERBB2 signaling"], "4146": ["ECM proteoglycans"], "4148": ["ECM proteoglycans", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "4149": ["Transcription of E2F targets under negative control by DREAM complex", "Cyclin E associated events during G1/S transition ", "Cyclin A:Cdk2-associated events at S phase entry", "Transcriptional Regulation by E2F6"], "414918": ["RAB GEFs exchange GTP for GDP on RABs"], "415": ["Glycosphingolipid metabolism", "The activation of arylsulfatases"], "4151": ["Intracellular oxygen transport"], "4152": ["SUMOylation of transcription cofactors"], "4153": ["Lectin pathway of complement activation", "Initial triggering of complement"], "4157": ["Peptide ligand-binding receptors", "G alpha (s) signalling events"], "4158": ["Peptide ligand-binding receptors", "G alpha (s) signalling events", "Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)"], "4159": ["Peptide ligand-binding receptors", "G alpha (s) signalling events"], "416": ["Glycosphingolipid metabolism", "The activation of arylsulfatases"], "4160": ["Peptide ligand-binding receptors", "G alpha (s) signalling events"], "4161": ["Peptide ligand-binding receptors", "G alpha (s) signalling events"], "4166": ["Keratan sulfate biosynthesis", "Defective CHST6 causes MCDC1"], "4168": ["Axonal growth inhibition (RHOA activation)", "NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "417": ["Alpha-defensins"], "4170": ["Interleukin-4 and Interleukin-13 signaling"], "4171": ["Activation of ATR in response to replication stress", "Unwinding of DNA", "Assembly of the pre-replicative complex", "Orc1 removal from chromatin", "Activation of the pre-replicative complex", "Switching of origins to a post-replicative state"], "4172": ["Activation of ATR in response to replication stress", "Unwinding of DNA", "Assembly of the pre-replicative complex", "Orc1 removal from chromatin", "Activation of the pre-replicative complex", "Switching of origins to a post-replicative state"], "4173": ["Activation of ATR in response to replication stress", "Unwinding of DNA", "Assembly of the pre-replicative complex", "Orc1 removal from chromatin", "Activation of the pre-replicative complex", "Switching of origins to a post-replicative state"], "4174": ["Activation of ATR in response to replication stress", "Unwinding of DNA", "Assembly of the pre-replicative complex", "Orc1 removal from chromatin", "Activation of the pre-replicative complex", "Switching of origins to a post-replicative state"], "4175": ["Activation of ATR in response to replication stress", "Unwinding of DNA", "Assembly of the pre-replicative complex", "Orc1 removal from chromatin", "Activation of the pre-replicative complex", "Switching of origins to a post-replicative state"], "4176": ["Activation of ATR in response to replication stress", "Unwinding of DNA", "Assembly of the pre-replicative complex", "Orc1 removal from chromatin", "Activation of the pre-replicative complex", "Switching of origins to a post-replicative state"], "4179": ["Regulation of Complement cascade"], "4185": ["LGI-ADAM interactions"], "4189": ["XBP1(S) activates chaperone genes"], "419": ["Post-translational modification: synthesis of GPI-anchored proteins"], "4190": ["Gluconeogenesis"], "4191": ["Gluconeogenesis", "Citric acid cycle (TCA cycle)"], "4192": ["NOTCH2 Activation and Transmission of Signal to the Nucleus"], "4193": ["AKT phosphorylates targets in the cytosol", "Oxidative Stress Induced Senescence", "Oncogene Induced Senescence", "SUMOylation of transcription factors", "SUMOylation of ubiquitinylation proteins", "Trafficking of AMPA receptors", "Constitutive Signaling by AKT1 E17K in Cancer", "Ub-specific processing proteases", "Regulation of TP53 Activity through Phosphorylation", "Regulation of TP53 Degradation", "Regulation of TP53 Activity through Methylation", "Stabilization of p53", "Regulation of RUNX3 expression and activity"], "4194": ["Oxidative Stress Induced Senescence", "Oncogene Induced Senescence", "Ub-specific processing proteases", "Regulation of TP53 Activity through Phosphorylation", "Regulation of TP53 Degradation", "Regulation of TP53 Activity through Methylation", "Stabilization of p53"], "4199": ["PPARA activates gene expression", "Pyruvate metabolism"], "420": ["Post-translational modification: synthesis of GPI-anchored proteins"], "4200": ["Citric acid cycle (TCA cycle)"], "4204": ["Transcriptional Regulation by MECP2", "Transcriptional Regulation by MECP2", "Loss of MECP2 binding ability to 5hmC-DNA", "Loss of phosphorylation of MECP2 at T308", "Loss of MECP2 binding ability to the NCoR/SMRT complex", "Loss of MECP2 binding ability to 5mC-DNA", "Regulation of MECP2 expression and activity", "Regulation of MECP2 expression and activity", "MECP2 regulates neuronal receptors and channels", "MECP2 regulates neuronal receptors and channels", "MECP2 regulates transcription of neuronal ligands", "MECP2 regulates transcription factors", "MECP2 regulates transcription of genes involved in GABA signaling"], "4205": ["ERK/MAPK targets", "CDO in myogenesis"], "4207": ["CDO in myogenesis"], "4208": ["ERK/MAPK targets", "Transcriptional activation of mitochondrial biogenesis", "CDO in myogenesis", "Circadian Clock", "MECP2 regulates transcription factors"], "4209": ["Transcriptional activation of mitochondrial biogenesis", "CDO in myogenesis", "Circadian Clock"], "4210": ["The NLRP3 inflammasome"], "4211": ["Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "4214": ["MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "FCERI mediated MAPK activation", "FCERI mediated MAPK activation", "TRAF6 mediated NF-kB activation", "TRAF6 mediated NF-kB activation", "TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "MyD88 cascade initiated on plasma membrane"], "4215": ["Interleukin-1 signaling"], "4217": ["Oxidative Stress Induced Senescence", "Oxidative Stress Induced Senescence"], "4218": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Regulation of PLK1 Activity at G2/M Transition", "Anchoring of the basal body to the plasma membrane", "VxPx cargo-targeting to cilium", "TBC/RABGAPs", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "4221": ["Formation of the beta-catenin:TCF transactivating complex", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Deactivation of the beta-catenin transactivating complex", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "RHO GTPases activate IQGAPs", "Post-translational protein phosphorylation"], "4233": ["PIP3 activates AKT signaling", "Constitutive Signaling by Aberrant PI3K in Cancer", "Sema4D mediated inhibition of cell attachment and migration", "RAF/MAP kinase cascade", "MET Receptor Activation", "Negative regulation of MET activity", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "MET activates RAS signaling", "MET activates PI3K/AKT signaling", "MET activates PTPN11", "MET activates PTK2 signaling", "InlB-mediated entry of Listeria monocytogenes into host cell", "InlB-mediated entry of Listeria monocytogenes into host cell", "MET interacts with TNS proteins", "MET activates RAP1 and RAC1", "MET receptor recycling", "MET activates STAT3", "MECP2 regulates neuronal receptors and channels"], "4234": ["tRNA modification in the nucleus and cytosol"], "4236": ["Molecules associated with elastic fibres"], "4237": ["Elastic fibre formation", "Molecules associated with elastic fibres", "Molecules associated with elastic fibres"], "4238": ["Molecules associated with elastic fibres"], "4239": ["Molecules associated with elastic fibres"], "4240": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation", "Amyloid fiber formation"], "4241": ["Post-translational modification: synthesis of GPI-anchored proteins", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "4242": ["Pre-NOTCH Processing in Golgi"], "4245": ["N-glycan trimming and elongation in the cis-Golgi"], "4247": ["Defective MGAT2 causes MGAT2-CDG (CDG-2a)", "Reactions specific to the complex N-glycan synthesis pathway"], "4248": ["Reactions specific to the hybrid N-glycan synthesis pathway"], "4249": ["N-Glycan antennae elongation"], "4253": ["Cargo concentration in the ER"], "4254": ["PIP3 activates AKT signaling", "Signaling by SCF-KIT", "Signaling by SCF-KIT", "Regulation of KIT signaling", "Regulation of KIT signaling", "Constitutive Signaling by Aberrant PI3K in Cancer", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "4255": ["MGMT-mediated DNA damage reversal"], "4257": ["Glutathione conjugation", "Aflatoxin activation and detoxification", "Neutrophil degranulation"], "4258": ["Glutathione conjugation", "Aflatoxin activation and detoxification"], "4259": ["Glutathione conjugation", "Aflatoxin activation and detoxification"], "4261": ["Interferon gamma signaling"], "4267": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall"], "427": ["Glycosphingolipid metabolism", "Neutrophil degranulation"], "4277": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "4281": ["Interferon gamma signaling"], "4282": ["Cell surface interactions at the vascular wall", "Neutrophil degranulation", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "4283": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "4284": ["Passive transport by Aquaporins"], "4286": ["SUMOylation of transcription factors"], "4287": ["Josephin domain DUBs", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes"], "4292": ["Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "Defective Mismatch Repair Associated With MLH1", "Defective Mismatch Repair Associated With PMS2", "TP53 Regulates Transcription of DNA Repair Genes", "Meiotic recombination"], "4295": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "4296": ["RAF activation", "Signaling by moderate kinase activity BRAF mutants", "Signaling by RAS mutants", "Paradoxical activation of RAF signaling by kinase inactive BRAF"], "4297": ["PKMTs methylate histone lysines", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "RUNX1 regulates transcription of genes involved in differentiation of HSCs"], "4298": ["Formation of RNA Pol II elongation complex ", "RNA Polymerase II Pre-transcription Events", "RNA Polymerase II Transcription Elongation"], "43": ["Neurotransmitter clearance", "Synthesis of PC", "Synthesis, secretion, and deacylation of Ghrelin"], "4300": ["Formation of RNA Pol II elongation complex ", "RNA Polymerase II Pre-transcription Events", "RNA Polymerase II Transcription Elongation"], "4301": ["Adherens junctions interactions", "Adherens junctions interactions"], "4303": ["AKT phosphorylates targets in the nucleus", "Constitutive Signaling by AKT1 E17K in Cancer", "Ub-specific processing proteases", "Regulation of localization of FOXO transcription factors", "FOXO-mediated transcription of cell death genes", "FOXO-mediated transcription of cell death genes", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "Regulation of FOXO transcriptional activity by acetylation", "FOXO-mediated transcription of cell cycle genes", "FOXO-mediated transcription of cell cycle genes"], "4306": ["HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Nuclear Receptor transcription pathway", "SUMOylation of intracellular receptors"], "4308": ["TRP channels"], "4311": ["Metabolism of Angiotensinogen to Angiotensins", "Neutrophil degranulation"], "4312": ["Collagen degradation", "Collagen degradation", "Degradation of the extracellular matrix", "Degradation of the extracellular matrix", "Activation of Matrix Metalloproteinases", "Basigin interactions", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Interleukin-4 and Interleukin-13 signaling"], "4313": ["Collagen degradation", "Collagen degradation", "Degradation of the extracellular matrix", "Degradation of the extracellular matrix", "Activation of Matrix Metalloproteinases", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "EPH-ephrin mediated repulsion of cells", "Interleukin-4 and Interleukin-13 signaling"], "4314": ["Collagen degradation", "Collagen degradation", "Degradation of the extracellular matrix", "Degradation of the extracellular matrix", "Activation of Matrix Metalloproteinases", "Assembly of collagen fibrils and other multimeric structures", "EGFR Transactivation by Gastrin", "EGFR Transactivation by Gastrin", "Interleukin-4 and Interleukin-13 signaling"], "4316": ["Collagen degradation", "Degradation of the extracellular matrix", "Degradation of the extracellular matrix", "Activation of Matrix Metalloproteinases", "Assembly of collagen fibrils and other multimeric structures"], "4317": ["Collagen degradation", "Degradation of the extracellular matrix", "Activation of Matrix Metalloproteinases", "Neutrophil degranulation"], "431704": ["G alpha (q) signalling events", "G alpha (i) signalling events", "G alpha (i) signalling events"], "4318": ["Signaling by SCF-KIT", "Collagen degradation", "Collagen degradation", "Degradation of the extracellular matrix", "Degradation of the extracellular matrix", "Activation of Matrix Metalloproteinases", "Assembly of collagen fibrils and other multimeric structures", "EPH-ephrin mediated repulsion of cells", "Interleukin-4 and Interleukin-13 signaling", "Neutrophil degranulation"], "4319": ["Collagen degradation", "Collagen degradation", "Degradation of the extracellular matrix", "Degradation of the extracellular matrix", "Activation of Matrix Metalloproteinases"], "432": ["Asparagine N-linked glycosylation"], "4320": ["Collagen degradation", "Degradation of the extracellular matrix", "Activation of Matrix Metalloproteinases"], "4321": ["Collagen degradation", "Degradation of the extracellular matrix", "Degradation of the extracellular matrix"], "4322": ["Collagen degradation", "Collagen degradation", "Degradation of the extracellular matrix", "Degradation of the extracellular matrix", "Activation of Matrix Metalloproteinases", "Assembly of collagen fibrils and other multimeric structures", "RUNX2 regulates genes involved in cell migration"], "4323": ["Collagen degradation", "Collagen degradation", "Degradation of the extracellular matrix", "Degradation of the extracellular matrix", "Activation of Matrix Metalloproteinases"], "4324": ["Collagen degradation", "Degradation of the extracellular matrix", "Degradation of the extracellular matrix", "Activation of Matrix Metalloproteinases"], "4325": ["Activation of Matrix Metalloproteinases"], "4326": ["Activation of Matrix Metalloproteinases"], "4327": ["Collagen degradation", "Degradation of the extracellular matrix", "Degradation of the extracellular matrix"], "4329": ["Branched-chain amino acid catabolism"], "433": ["Asparagine N-linked glycosylation"], "4331": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Tat-mediated elongation of the HIV-1 transcript", "NoRC negatively regulates rRNA expression", "Formation of Incision Complex in GG-NER", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "Cyclin E associated events during G1/S transition ", "Cyclin D associated events in G1", "Cyclin A/B1/B2 associated events during G2/M transition", "Cyclin A:Cdk2-associated events at S phase entry", "mRNA Capping", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase I Transcription Termination", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE", "RUNX1 regulates transcription of genes involved in differentiation of HSCs"], "4332": ["Neutrophil degranulation"], "4336": ["Transcriptional Regulation by MECP2"], "4337": ["Molybdenum cofactor biosynthesis"], "4338": ["Molybdenum cofactor biosynthesis"], "4343": ["Pre-NOTCH Transcription and Translation", "Oxidative Stress Induced Senescence", "Oncogene Induced Senescence", "Ca2+ pathway", "TP53 Regulates Metabolic Genes", "MAPK6/MAPK4 signaling", "Regulation of RUNX1 Expression and Activity", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Regulation of PTEN mRNA translation", "Competing endogenous RNAs (ceRNAs) regulate PTEN translation", "Transcriptional Regulation by MECP2", "Transcriptional Regulation by MECP2", "Estrogen-dependent gene expression", "Regulation of MECP2 expression and activity"], "4345": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "435": ["Urea cycle"], "4350": ["Recognition and association of DNA glycosylase with site containing an affected purine", "Cleavage of the damaged purine", "Displacement of DNA glycosylase by APEX1"], "4351": ["Defective MPI causes MPI-CDG (CDG-1b)", "Synthesis of GDP-mannose"], "4352": ["Platelet Aggregation (Plug Formation)"], "4353": ["Neutrophil degranulation", "Events associated with phagocytolytic activity of PMN cells"], "4357": ["Degradation of cysteine and homocysteine"], "4358": ["Peroxisomal protein import", "Peroxisomal protein import"], "4360": ["Cross-presentation of soluble exogenous antigens (endosomes)", "Cross-presentation of soluble exogenous antigens (endosomes)"], "4361": ["Cytosolic sensors of pathogen-associated DNA ", "DNA Damage/Telomere Stress Induced Senescence", "IRF3-mediated induction of type I IFN", "HDR through Single Strand Annealing (SSA)", "HDR through MMEJ (alt-NHEJ)", "HDR through Homologous Recombination (HRR)", "Sensing of DNA Double Strand Breaks", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Nonhomologous End-Joining (NHEJ)", "Homologous DNA Pairing and Strand Exchange", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Regulation of TP53 Activity through Phosphorylation", "G2/M DNA damage checkpoint", "Meiotic recombination"], "4363": ["Cobalamin (Cbl, vitamin B12) transport and metabolism", "Synthesis of Leukotrienes (LT) and Eoxins (EX)", "ABC-family proteins mediated transport"], "438": ["Serotonin and melatonin biosynthesis"], "43847": ["Formation of the cornified envelope"], "43849": ["Formation of the cornified envelope"], "439": ["XBP1(S) activates chaperone genes"], "439915": ["Keratinization"], "440": ["ATF4 activates genes", "Amino acid synthesis and interconversion (transamination)"], "440021": ["Keratinization"], "440023": ["Keratinization"], "440050": ["Keratinization"], "440051": ["Keratinization"], "440077": ["Generic Transcription Pathway"], "440138": ["Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "Defective ALG11 causes ALG11-CDG (CDG-1p)"], "440145": ["Recruitment of mitotic centrosome proteins and complexes", "Recruitment of NuMA to mitotic centrosomes"], "440193": ["Negative regulation of TCF-dependent signaling by DVL-interacting proteins"], "440387": ["Activation of Matrix Metalloproteinases", "Cobalamin (Cbl, vitamin B12) transport and metabolism"], "440515": ["Generic Transcription Pathway"], "440533": ["Cell surface interactions at the vascular wall"], "440574": ["Cristae formation"], "440689": ["HDACs deacetylate histones", "HATs acetylate histones", "HATs acetylate histones", "Ub-specific processing proteases"], "440738": ["Macroautophagy"], "440854": ["Degradation of the extracellular matrix"], "441024": ["Metabolism of folate and pterines"], "441234": ["Generic Transcription Pathway"], "441282": ["Estrogen biosynthesis"], "441308": ["Olfactory Signaling Pathway"], "441509": ["Neurotransmitter receptors and postsynaptic signal transmission"], "441608": ["Olfactory Signaling Pathway"], "441639": ["Olfactory Signaling Pathway"], "441669": ["Olfactory Signaling Pathway"], "441670": ["Olfactory Signaling Pathway"], "441864": ["Neutrophil degranulation"], "441911": ["Olfactory Signaling Pathway"], "441932": ["Olfactory Signaling Pathway"], "441933": ["Olfactory Signaling Pathway"], "442117": ["O-linked glycosylation of mucins"], "442184": ["Olfactory Signaling Pathway"], "442185": ["Olfactory Signaling Pathway"], "442186": ["Olfactory Signaling Pathway"], "442191": ["Olfactory Signaling Pathway"], "442194": ["Olfactory Signaling Pathway"], "442319": ["Generic Transcription Pathway"], "442361": ["Olfactory Signaling Pathway"], "443": ["Amino acid synthesis and interconversion (transamination)"], "4435": ["Activation of the TFAP2 (AP-2) family of transcription factors", "Estrogen-dependent gene expression"], "4436": ["Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "Defective Mismatch Repair Associated With MSH3", "Defective Mismatch Repair Associated With MSH2", "Defective Mismatch Repair Associated With MSH6", "TP53 Regulates Transcription of DNA Repair Genes"], "4437": ["Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "Defective Mismatch Repair Associated With MSH3", "Defective Mismatch Repair Associated With MSH2"], "4438": ["Meiotic recombination"], "4439": ["Meiotic recombination"], "444": ["Stimuli-sensing channels", "Ion homeostasis"], "4440": ["Regulation of expression of SLITs and ROBOs"], "445": ["Urea cycle"], "445328": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "445329": ["Cytosolic sulfonation of small molecules", "XBP1(S) activates chaperone genes"], "4478": ["Recycling pathway of L1", "Recycling pathway of L1", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "4481": ["Scavenging by Class A Receptors", "Scavenging by Class A Receptors"], "4482": ["Protein repair"], "4485": ["Signaling by MST1"], "4486": ["Signaling by MST1"], "4488": ["Regulation of RUNX2 expression and activity"], "448835": ["Formation of the cornified envelope"], "4489": ["Metallothioneins bind metals", "Metallothioneins bind metals"], "4490": ["Metallothioneins bind metals"], "4493": ["Metallothioneins bind metals"], "4494": ["Metallothioneins bind metals"], "4495": ["Metallothioneins bind metals"], "4496": ["Metallothioneins bind metals"], "4499": ["Metallothioneins bind metals"], "4501": ["Metallothioneins bind metals"], "4502": ["Metallothioneins bind metals", "Metallothioneins bind metals", "Interferon gamma signaling"], "4504": ["Metallothioneins bind metals", "Metallothioneins bind metals"], "4507": ["Methionine salvage pathway", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "4508": ["Formation of ATP by chemiosmotic coupling", "Cristae formation"], "4509": ["Formation of ATP by chemiosmotic coupling", "Cristae formation"], "4512": ["TP53 Regulates Metabolic Genes", "Respiratory electron transport"], "4513": ["TP53 Regulates Metabolic Genes", "Respiratory electron transport"], "4514": ["TP53 Regulates Metabolic Genes", "Respiratory electron transport"], "4519": ["Respiratory electron transport"], "4520": ["PPARA activates gene expression", "Activation of gene expression by SREBF (SREBP)", "MTF1 activates gene expression", "MTF1 activates gene expression"], "4521": ["Phosphate bond hydrolysis by NUDT proteins"], "4522": ["Metabolism of folate and pterines"], "4524": ["Metabolism of folate and pterines"], "4528": ["Mitochondrial translation initiation"], "4534": ["Synthesis of PIPs at the plasma membrane", "Synthesis of PIPs at the early endosome membrane", "Synthesis of PIPs at the late endosome membrane"], "4535": ["Respiratory electron transport", "Complex I biogenesis"], "4536": ["Respiratory electron transport", "Complex I biogenesis"], "4537": ["Respiratory electron transport", "Complex I biogenesis"], "4538": ["Respiratory electron transport", "Complex I biogenesis"], "4540": ["Respiratory electron transport", "Complex I biogenesis"], "4541": ["Respiratory electron transport", "Complex I biogenesis"], "4543": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (i) signalling events"], "4544": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (i) signalling events"], "4547": ["VLDL assembly", "Chylomicron assembly"], "4548": ["Methylation", "Sulfur amino acid metabolism", "Cobalamin (Cbl, vitamin B12) transport and metabolism", "Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE", "Defective MTR causes methylmalonic aciduria and homocystinuria type cblG"], "4552": ["Methylation", "Sulfur amino acid metabolism", "Cobalamin (Cbl, vitamin B12) transport and metabolism", "Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE", "Defective MTR causes methylmalonic aciduria and homocystinuria type cblG"], "4580": ["Mitochondrial protein import", "Cristae formation"], "4582": ["Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)", "Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)", "Defective GALNT12 causes colorectal cancer 1 (CRCS1)", "Dectin-2 family", "Interleukin-4 and Interleukin-13 signaling", "O-linked glycosylation of mucins", "Termination of O-glycan biosynthesis"], "4584": ["Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)", "Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)", "Defective GALNT12 causes colorectal cancer 1 (CRCS1)", "Dectin-2 family", "O-linked glycosylation of mucins", "Termination of O-glycan biosynthesis"], "4585": ["Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)", "Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)", "Defective GALNT12 causes colorectal cancer 1 (CRCS1)", "Dectin-2 family", "O-linked glycosylation of mucins", "Termination of O-glycan biosynthesis"], "4586": ["Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)", "Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)", "Defective GALNT12 causes colorectal cancer 1 (CRCS1)", "Dectin-2 family", "O-linked glycosylation of mucins", "Termination of O-glycan biosynthesis"], "4588": ["Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)", "Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)", "Defective GALNT12 causes colorectal cancer 1 (CRCS1)", "Dectin-2 family", "O-linked glycosylation of mucins", "Termination of O-glycan biosynthesis"], "4589": ["Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)", "Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)", "Defective GALNT12 causes colorectal cancer 1 (CRCS1)", "Dectin-2 family", "O-linked glycosylation of mucins", "Termination of O-glycan biosynthesis"], "4591": ["Antigen processing: Ubiquitination & Proteasome degradation"], "4593": ["ECM proteoglycans"], "4594": ["Cobalamin (Cbl, vitamin B12) transport and metabolism", "Defective MMAA causes methylmalonic aciduria type cblA", "Defective MUT causes methylmalonic aciduria mut type", "Propionyl-CoA catabolism"], "4595": ["Recognition and association of DNA glycosylase with site containing an affected purine", "Cleavage of the damaged purine", "Displacement of DNA glycosylase by APEX1", "Defective MUTYH substrate binding", "Defective MUTYH substrate processing"], "4597": ["Cholesterol biosynthesis", "Activation of gene expression by SREBF (SREBP)", "Synthesis of Dolichyl-phosphate"], "4598": ["Cholesterol biosynthesis", "Activation of gene expression by SREBF (SREBP)"], "4599": ["ISG15 antiviral mechanism", "Interferon alpha/beta signaling"], "4600": ["ISG15 antiviral mechanism", "Interferon alpha/beta signaling"], "4602": ["RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Factors involved in megakaryocyte development and platelet production"], "4603": ["PIWI-interacting RNA (piRNA) biogenesis"], "4604": ["Striated Muscle Contraction"], "4605": ["Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1", "Polo-like kinase mediated events", "TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation"], "4606": ["Striated Muscle Contraction"], "4607": ["Striated Muscle Contraction"], "4609": ["Transcription of E2F targets under negative control by DREAM complex", "NOTCH1 Intracellular Domain Regulates Transcription", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "Binding of TCF/LEF:CTNNB1 to target gene promoters", "MAPK6/MAPK4 signaling", "Ub-specific processing proteases", "Interleukin-4 and Interleukin-13 signaling", "Cyclin E associated events during G1/S transition ", "Cyclin A:Cdk2-associated events at S phase entry", "TFAP2 (AP-2) family regulates transcription of cell cycle factors", "RUNX3 regulates WNT signaling", "Estrogen-dependent gene expression"], "4615": ["ER-Phagosome pathway", "PIP3 activates AKT signaling", "MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "RIP-mediated NFkB activation via ZBP1", "p75NTR recruits signalling complexes", "p75NTR recruits signalling complexes", "DEx/H-box helicases activate type I IFN and inflammatory cytokines production ", "MyD88 deficiency (TLR2/4)", "MyD88 deficiency (TLR5)", "IRAK4 deficiency (TLR5)", "IRAK4 deficiency (TLR2/4)", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Interleukin-1 signaling", "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "MyD88 dependent cascade initiated on endosome", "MyD88 cascade initiated on plasma membrane"], "4617": ["CDO in myogenesis", "CDO in myogenesis"], "4618": ["CDO in myogenesis", "CDO in myogenesis"], "462": ["Intrinsic Pathway of Fibrin Clot Formation", "Common Pathway of Fibrin Clot Formation", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "4620": ["Regulation of actin dynamics for phagocytic cup formation"], "4621": ["Striated Muscle Contraction"], "4624": ["Striated Muscle Contraction"], "4626": ["Striated Muscle Contraction"], "4627": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Regulation of actin dynamics for phagocytic cup formation", "EPHA-mediated growth cone collapse", "Sema4D induced cell migration and growth-cone collapse", "RHO GTPases activate PKNs", "RHO GTPases activate CIT", "RHO GTPases Activate ROCKs", "RHO GTPases activate PAKs", "RHO GTPases activate PAKs"], "4628": ["EPHA-mediated growth cone collapse", "Sema4D induced cell migration and growth-cone collapse", "RHO GTPases activate PKNs", "RHO GTPases activate CIT", "RHO GTPases Activate ROCKs", "RHO GTPases activate PAKs", "RHO GTPases activate PAKs"], "4629": ["EPHA-mediated growth cone collapse", "Sema4D induced cell migration and growth-cone collapse", "Smooth Muscle Contraction", "RHO GTPases activate PKNs", "RHO GTPases activate CIT", "RHO GTPases Activate ROCKs", "RHO GTPases activate PAKs", "RHO GTPases activate PAKs"], "463": ["RUNX3 regulates CDKN1A transcription"], "4632": ["Striated Muscle Contraction"], "4633": ["Striated Muscle Contraction"], "4634": ["Striated Muscle Contraction"], "4635": ["Striated Muscle Contraction"], "4636": ["Smooth Muscle Contraction"], "4637": ["EPHA-mediated growth cone collapse", "Sema4D induced cell migration and growth-cone collapse", "Smooth Muscle Contraction", "RHO GTPases activate PKNs", "RHO GTPases activate CIT", "RHO GTPases Activate ROCKs", "RHO GTPases activate PAKs", "RHO GTPases activate PAKs"], "4638": ["Smooth Muscle Contraction", "RHO GTPases activate PAKs", "RHO GTPases activate PAKs"], "4641": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Regulation of actin dynamics for phagocytic cup formation", "B-WICH complex positively regulates rRNA expression"], "4644": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Regulation of actin dynamics for phagocytic cup formation", "Insulin processing"], "4645": ["Vasopressin regulates renal water homeostasis via Aquaporins"], "4646": ["Gap junction degradation", "Trafficking of AMPA receptors"], "4647": ["The canonical retinoid cycle in rods (twilight vision)"], "4649": ["Rho GTPase cycle"], "4650": ["Rho GTPase cycle", "Regulation of actin dynamics for phagocytic cup formation", "SLIT2:ROBO1 increases RHOA activity"], "4651": ["Regulation of actin dynamics for phagocytic cup formation", "Netrin-1 signaling"], "4654": ["CDO in myogenesis", "CDO in myogenesis"], "4656": ["CDO in myogenesis", "CDO in myogenesis"], "4659": ["Regulation of PLK1 Activity at G2/M Transition", "RHO GTPases activate PKNs", "RHO GTPases activate PKNs", "RHO GTPases activate CIT", "RHO GTPases Activate ROCKs", "RHO GTPases activate PAKs", "RHO GTPases activate PAKs"], "466": ["CREB phosphorylation"], "4660": ["Regulation of PLK1 Activity at G2/M Transition", "RHO GTPases activate PKNs", "RHO GTPases activate PKNs", "RHO GTPases activate CIT", "RHO GTPases Activate ROCKs", "RHO GTPases activate PAKs", "RHO GTPases activate PAKs"], "4669": ["HS-GAG degradation", "MPS IIIB - Sanfilippo syndrome B"], "467": ["ATF4 activates genes"], "4670": ["FGFR2 alternative splicing", "mRNA Splicing - Major Pathway", "Processing of Capped Intron-Containing Pre-mRNA"], "4677": ["Cytosolic tRNA aminoacylation"], "468": ["ATF4 activates genes", "PERK regulates gene expression", "ATF6 (ATF6-alpha) activates chaperone genes"], "4680": ["Fibronectin matrix formation", "Cell surface interactions at the vascular wall", "Neutrophil degranulation"], "4682": ["Cytosolic iron-sulfur cluster assembly"], "4683": ["DNA Damage/Telomere Stress Induced Senescence", "HDR through Single Strand Annealing (SSA)", "HDR through MMEJ (alt-NHEJ)", "HDR through Homologous Recombination (HRR)", "Sensing of DNA Double Strand Breaks", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Nonhomologous End-Joining (NHEJ)", "Homologous DNA Pairing and Strand Exchange", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Regulation of TP53 Activity through Phosphorylation", "G2/M DNA damage checkpoint", "Meiotic recombination"], "4684": ["ECM proteoglycans", "NCAM signaling for neurite out-growth", "NCAM signaling for neurite out-growth", "NCAM1 interactions", "NCAM1 interactions", "Signal transduction by L1", "RAF/MAP kinase cascade", "Interferon gamma signaling"], "4686": ["Cleavage of Growing Transcript in the Termination Region ", "SLBP independent Processing of Histone Pre-mRNAs", "Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Abortive elongation of HIV-1 transcript in the absence of Tat", "snRNP Assembly", "RNA Polymerase II Pre-transcription Events", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "mRNA 3'-end processing", "Processing of Capped Intron-Containing Pre-mRNA", "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "Processing of Intronless Pre-mRNAs", "Signaling by FGFR2 IIIa TM", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "4688": ["ROS, RNS production in phagocytes", "Cross-presentation of particulate exogenous antigens (phagosomes)", "Detoxification of Reactive Oxygen Species", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate NADPH Oxidases"], "4689": ["ROS, RNS production in phagocytes", "Cross-presentation of particulate exogenous antigens (phagosomes)", "Detoxification of Reactive Oxygen Species", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate NADPH Oxidases"], "4690": ["Downstream signal transduction", "Generation of second messenger molecules", "Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "Nephrin family interactions", "DCC mediated attractive signaling", "DCC mediated attractive signaling", "Activation of RAC1", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "4691": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "4692": ["Interleukin-4 and Interleukin-13 signaling"], "4694": ["Respiratory electron transport", "Complex I biogenesis"], "4695": ["Respiratory electron transport", "Complex I biogenesis"], "4696": ["Respiratory electron transport", "Complex I biogenesis"], "4697": ["TP53 Regulates Metabolic Genes", "Respiratory electron transport"], "4698": ["Respiratory electron transport", "Complex I biogenesis"], "47": ["ChREBP activates metabolic gene expression", "Neutrophil degranulation", "Fatty acyl-CoA biosynthesis"], "4700": ["Respiratory electron transport", "Complex I biogenesis"], "4701": ["Respiratory electron transport", "Complex I biogenesis"], "4702": ["Respiratory electron transport", "Complex I biogenesis"], "4703": ["Striated Muscle Contraction"], "4704": ["Respiratory electron transport", "Complex I biogenesis"], "4705": ["Respiratory electron transport", "Complex I biogenesis"], "4706": ["Glyoxylate metabolism and glycine degradation", "Respiratory electron transport", "Complex I biogenesis", "Mitochondrial Fatty Acid Beta-Oxidation"], "4707": ["Respiratory electron transport", "Complex I biogenesis"], "4708": ["Respiratory electron transport", "Complex I biogenesis"], "4709": ["Respiratory electron transport", "Complex I biogenesis"], "471": ["Purine ribonucleoside monophosphate biosynthesis"], "4710": ["Respiratory electron transport", "Complex I biogenesis"], "4711": ["Respiratory electron transport", "Complex I biogenesis"], "4712": ["Respiratory electron transport", "Complex I biogenesis"], "4713": ["Respiratory electron transport", "Complex I biogenesis"], "4714": ["Mitochondrial protein import", "Mitochondrial protein import", "Respiratory electron transport", "Complex I biogenesis"], "4715": ["Respiratory electron transport", "Complex I biogenesis"], "4716": ["Respiratory electron transport", "Complex I biogenesis"], "4717": ["Respiratory electron transport", "Complex I biogenesis"], "4718": ["Respiratory electron transport", "Neutrophil degranulation", "Complex I biogenesis"], "4719": ["Respiratory electron transport", "Complex I biogenesis"], "472": ["DNA Damage/Telomere Stress Induced Senescence", "Regulation of HSF1-mediated heat shock response", "Autodegradation of the E3 ubiquitin ligase COP1", "HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Sensing of DNA Double Strand Breaks", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Nonhomologous End-Joining (NHEJ)", "Homologous DNA Pairing and Strand Exchange", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "TP53 Regulates Transcription of DNA Repair Genes", "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "TP53 Regulates Transcription of Caspase Activators and Caspases", "Regulation of TP53 Activity through Phosphorylation", "Regulation of TP53 Degradation", "Regulation of TP53 Activity through Methylation", "G2/M DNA damage checkpoint", "Stabilization of p53", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "Meiotic recombination"], "4720": ["Respiratory electron transport", "Complex I biogenesis"], "4722": ["Respiratory electron transport", "Complex I biogenesis"], "4723": ["Respiratory electron transport", "Complex I biogenesis"], "4724": ["Respiratory electron transport", "Complex I biogenesis"], "4725": ["Respiratory electron transport", "Complex I biogenesis"], "4726": ["Respiratory electron transport", "Complex I biogenesis"], "4728": ["Respiratory electron transport", "Complex I biogenesis"], "4729": ["Respiratory electron transport", "Complex I biogenesis"], "4731": ["Respiratory electron transport", "Complex I biogenesis"], "4734": ["ISG15 antiviral mechanism", "Downregulation of ERBB4 signaling", "Regulation of PTEN localization", "Regulation of PTEN stability and activity", "Antigen processing: Ubiquitination & Proteasome degradation"], "4735": ["Anchoring of the basal body to the plasma membrane"], "4736": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "4738": ["TGF-beta receptor signaling activates SMADs", "UCH proteinases", "Cargo recognition for clathrin-mediated endocytosis", "Neddylation", "Iron uptake and transport"], "474382": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Deposition of new CENPA-containing nucleosomes at the centromere", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "4747": ["Unblocking of NMDA receptors, glutamate binding and activation", "Unblocking of NMDA receptors, glutamate binding and activation", "Ras activation upon Ca2+ influx through NMDA receptor", "RAF/MAP kinase cascade", "Negative regulation of NMDA receptor-mediated neuronal transmission", "Long-term potentiation"], "475": ["Detoxification of Reactive Oxygen Species", "Ion influx/efflux at host-pathogen interface"], "4751": ["APC-Cdc20 mediated degradation of Nek2A", "Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "4753": ["Regulation of commissural axon pathfinding by SLIT and ROBO"], "4756": ["Netrin-1 signaling", "CDO in myogenesis"], "4758": ["Glycosphingolipid metabolism", "Sialic acid metabolism", "Defective NEU1 causes sialidosis", "Neutrophil degranulation"], "4759": ["Glycosphingolipid metabolism", "Sialic acid metabolism"], "476": ["Ion homeostasis", "Ion transport by P-type ATPases"], "4760": ["Regulation of gene expression in beta cells", "Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells"], "4763": ["Regulation of RAS by GAPs", "Signaling by RAS mutants", "RAS signaling downstream of NF1 loss-of-function variants"], "477": ["Ion homeostasis", "Ion transport by P-type ATPases"], "4771": ["Regulation of actin dynamics for phagocytic cup formation", "RHO GTPases activate PAKs"], "4772": ["Calcineurin activates NFAT", "Calcineurin activates NFAT", "FCERI mediated Ca+2 mobilization", "Ca2+ pathway", "CLEC7A (Dectin-1) induces NFAT activation"], "4773": ["Calcineurin activates NFAT", "Calcineurin activates NFAT", "FCERI mediated Ca+2 mobilization", "CLEC7A (Dectin-1) induces NFAT activation", "RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)"], "4774": ["RNA Polymerase III Transcription Termination", "RNA Polymerase III Abortive And Retractive Initiation"], "4775": ["Calcineurin activates NFAT", "Calcineurin activates NFAT", "FCERI mediated Ca+2 mobilization", "CLEC7A (Dectin-1) induces NFAT activation"], "4778": ["RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Factors involved in megakaryocyte development and platelet production", "Factors involved in megakaryocyte development and platelet production"], "478": ["Ion homeostasis", "Ion transport by P-type ATPases"], "4781": ["RNA Polymerase III Transcription Termination", "RNA Polymerase III Abortive And Retractive Initiation"], "4782": ["RNA Polymerase III Transcription Termination", "RNA Polymerase III Abortive And Retractive Initiation"], "4783": ["Circadian Clock"], "4784": ["RNA Polymerase III Transcription Termination", "RNA Polymerase III Abortive And Retractive Initiation"], "479": ["Ion transport by P-type ATPases"], "4790": ["Activation of NF-kappaB in B cells", "RIP-mediated NFkB activation via ZBP1", "Regulated proteolysis of p75NTR", "Downstream TCR signaling", "NF-kB is activated and signals survival", "Senescence-Associated Secretory Phenotype (SASP)", "FCERI mediated NF-kB activation", "DEx/H-box helicases activate type I IFN and inflammatory cytokines production ", "PKMTs methylate histone lysines", "Transcriptional regulation of white adipocyte differentiation", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "Interleukin-1 processing", "IkBA variant leads to EDA-ID", "CLEC7A (Dectin-1) signaling", "CD209 (DC-SIGN) signaling", "CLEC7A/inflammasome pathway", "MAP3K8 (TPL2)-dependent MAPK1/3 activation", "Neutrophil degranulation", "The NLRP3 inflammasome", "Interleukin-1 signaling", "TRAF6 mediated NF-kB activation"], "4791": ["RIP-mediated NFkB activation via ZBP1", "DEx/H-box helicases activate type I IFN and inflammatory cytokines production ", "PKMTs methylate histone lysines", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "Interleukin-1 processing", "SUMOylation of immune response proteins", "IkBA variant leads to EDA-ID", "Dectin-1 mediated noncanonical NF-kB signaling", "NIK-->noncanonical NF-kB signaling", "The NLRP3 inflammasome", "TRAF6 mediated NF-kB activation"], "4792": ["Activation of NF-kappaB in B cells", "RIP-mediated NFkB activation via ZBP1", "Downstream TCR signaling", "NF-kB is activated and signals survival", "FCERI mediated NF-kB activation", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "SUMOylation of immune response proteins", "IkBA variant leads to EDA-ID", "CLEC7A (Dectin-1) signaling", "Ub-specific processing proteases", "Interleukin-1 signaling", "TRAF6 mediated NF-kB activation"], "4793": ["Activation of NF-kappaB in B cells", "RIP-mediated NFkB activation via ZBP1", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "TRAF6 mediated NF-kB activation"], "4794": ["Activation of NF-kappaB in B cells"], "4798": ["UCH proteinases", "DNA Damage Recognition in GG-NER"], "48": ["Iron uptake and transport"], "480": ["Ion homeostasis", "Ion transport by P-type ATPases"], "4800": ["PPARA activates gene expression", "Activation of gene expression by SREBF (SREBP)", "Activation of gene expression by SREBF (SREBP)", "ATF4 activates genes", "ATF6 (ATF6-alpha) activates chaperone genes", "FOXO-mediated transcription of cell death genes"], "4801": ["PPARA activates gene expression", "Activation of gene expression by SREBF (SREBP)", "Activation of gene expression by SREBF (SREBP)", "ATF4 activates genes", "ATF6 (ATF6-alpha) activates chaperone genes", "FOXO-mediated transcription of cell death genes"], "4802": ["PPARA activates gene expression", "Activation of gene expression by SREBF (SREBP)", "Activation of gene expression by SREBF (SREBP)", "ATF4 activates genes", "ATF6 (ATF6-alpha) activates chaperone genes", "FOXO-mediated transcription of cell death genes"], "4803": ["PLC-gamma1 signalling", "Signalling to RAS", "NGF processing", "NGF processing", "Frs2-mediated activation", "Frs2-mediated activation", "ARMS-mediated activation", "ARMS-mediated activation", "Retrograde neurotrophin signalling", "Retrograde neurotrophin signalling", "TRKA activation by NGF", "TRKA activation by NGF", "Signalling to p38 via RIT and RIN", "NRAGE signals death through JNK", "p75NTR negatively regulates cell cycle via SC1", "Ceramide signalling", "PI3K/AKT activation", "PI3K/AKT activation", "Signalling to STAT3", "NFG and proNGF binds to p75NTR", "NADE modulates death signalling", "NRIF signals cell death from the nucleus", "NRIF signals cell death from the nucleus", "p75NTR recruits signalling complexes", "p75NTR recruits signalling complexes", "NF-kB is activated and signals survival", "Axonal growth stimulation"], "4804": ["Axonal growth inhibition (RHOA activation)", "NRAGE signals death through JNK", "p75NTR negatively regulates cell cycle via SC1", "Ceramide signalling", "Regulated proteolysis of p75NTR", "NFG and proNGF binds to p75NTR", "NADE modulates death signalling", "NRIF signals cell death from the nucleus", "NRIF signals cell death from the nucleus", "p75NTR recruits signalling complexes", "p75NTR recruits signalling complexes", "NF-kB is activated and signals survival", "Axonal growth stimulation"], "4809": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "481": ["Basigin interactions", "Ion homeostasis", "Ion transport by P-type ATPases"], "4811": ["Degradation of the extracellular matrix", "Degradation of the extracellular matrix", "Laminin interactions", "Laminin interactions"], "482": ["Basigin interactions", "Ion homeostasis", "Ion transport by P-type ATPases"], "4821": ["Regulation of gene expression in beta cells", "Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells"], "4825": ["Regulation of gene expression in beta cells", "Regulation of gene expression in early pancreatic precursor cells"], "4828": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "4829": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "483": ["Basigin interactions", "Ion homeostasis", "Ion transport by P-type ATPases"], "4830": ["Interconversion of nucleotide di- and triphosphates"], "4831": ["Interconversion of nucleotide di- and triphosphates", "Neutrophil degranulation"], "4832": ["Interconversion of nucleotide di- and triphosphates"], "4833": ["Interconversion of nucleotide di- and triphosphates"], "4835": ["Phase I - Functionalization of compounds"], "4836": ["Late Phase of HIV Life Cycle", "Inactivation, recovery and regulation of the phototransduction cascade", "Activation, myristolyation of BID and translocation to mitochondria"], "4837": ["Methylation", "Nicotinamide salvaging", "Metabolism of ingested SeMet, Sec, MeSec into H2Se"], "4838": ["Signaling by NODAL", "Regulation of signaling by NODAL"], "4839": ["rRNA modification in the nucleus and cytosol", "TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation"], "4842": ["ROS, RNS production in phagocytes", "Nitric oxide stimulates guanylate cyclase", "Ion homeostasis"], "4843": ["ROS, RNS production in phagocytes", "Nitric oxide stimulates guanylate cyclase", "Interleukin-4 and Interleukin-13 signaling", "Peroxisomal protein import", "Peroxisomal protein import"], "4846": ["ROS, RNS production in phagocytes", "Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "eNOS activation", "NOSTRIN mediated eNOS trafficking", "NOSIP mediated eNOS trafficking", "Nitric oxide stimulates guanylate cyclase", "VEGFR2 mediated vascular permeability"], "4848": ["Deadenylation of mRNA", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "4849": ["Deadenylation of mRNA", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "4850": ["Deadenylation of mRNA", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "4851": ["Pre-NOTCH Processing in the Endoplasmic Reticulum", "Pre-NOTCH Transcription and Translation", "Pre-NOTCH Transcription and Translation", "Pre-NOTCH Processing in Golgi", "Pre-NOTCH Processing in Golgi", "Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "NOTCH1 Intracellular Domain Regulates Transcription", "NOTCH1 Intracellular Domain Regulates Transcription", "Activated NOTCH1 Transmits Signal to the Nucleus", "Activated NOTCH1 Transmits Signal to the Nucleus", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling", "Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant", "Constitutive Signaling by NOTCH1 HD Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "Notch-HLH transcription pathway", "Defective LFNG causes SCDO3", "RUNX3 regulates NOTCH signaling", "RUNX3 regulates NOTCH signaling", "NOTCH3 Intracellular Domain Regulates Transcription", "NOTCH3 Intracellular Domain Regulates Transcription", "NOTCH4 Intracellular Domain Regulates Transcription"], "4852": ["Peptide ligand-binding receptors", "G alpha (i) signalling events", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes"], "4853": ["Pre-NOTCH Processing in the Endoplasmic Reticulum", "Pre-NOTCH Transcription and Translation", "Pre-NOTCH Processing in Golgi", "Pre-NOTCH Processing in Golgi", "NOTCH2 intracellular domain regulates transcription", "NOTCH2 intracellular domain regulates transcription", "NOTCH2 Activation and Transmission of Signal to the Nucleus", "NOTCH2 Activation and Transmission of Signal to the Nucleus", "Notch-HLH transcription pathway", "Defective LFNG causes SCDO3", "NOTCH4 Intracellular Domain Regulates Transcription"], "4854": ["Pre-NOTCH Processing in the Endoplasmic Reticulum", "Pre-NOTCH Transcription and Translation", "Pre-NOTCH Processing in Golgi", "Pre-NOTCH Processing in Golgi", "Notch-HLH transcription pathway", "Defective LFNG causes SCDO3", "NOTCH3 Activation and Transmission of Signal to the Nucleus", "NOTCH3 Activation and Transmission of Signal to the Nucleus", "NOTCH3 Intracellular Domain Regulates Transcription", "NOTCH3 Intracellular Domain Regulates Transcription", "Noncanonical activation of NOTCH3"], "4855": ["Pre-NOTCH Processing in the Endoplasmic Reticulum", "Pre-NOTCH Transcription and Translation", "Pre-NOTCH Processing in Golgi", "Pre-NOTCH Processing in Golgi", "Notch-HLH transcription pathway", "Defective LFNG causes SCDO3", "NOTCH4 Intracellular Domain Regulates Transcription", "NOTCH4 Intracellular Domain Regulates Transcription", "NOTCH4 Activation and Transmission of Signal to the Nucleus", "NOTCH4 Activation and Transmission of Signal to the Nucleus", "Negative regulation of NOTCH4 signaling", "Negative regulation of NOTCH4 signaling"], "486": ["Ion homeostasis", "Ion transport by P-type ATPases"], "4860": ["Neutrophil degranulation", "Purine salvage", "Purine catabolism"], "4862": ["BMAL1:CLOCK,NPAS2 activates circadian gene expression", "BMAL1:CLOCK,NPAS2 activates circadian gene expression", "PPARA activates gene expression", "PPARA activates gene expression", "Circadian Clock", "Circadian Clock"], "4864": ["LDL clearance"], "4867": ["Anchoring of the basal body to the plasma membrane"], "4868": ["Nephrin family interactions", "Nephrin family interactions"], "4869": ["Nuclear import of Rev protein", "Nuclear import of Rev protein", "SUMOylation of transcription cofactors", "Deposition of new CENPA-containing nucleosomes at the centromere", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation"], "487": ["Pre-NOTCH Processing in Golgi", "Reduction of cytosolic Ca++ levels", "Ion homeostasis", "Ion transport by P-type ATPases"], "4878": ["YAP1- and WWTR1 (TAZ)-stimulated gene expression", "Physiological factors", "Amyloid fiber formation"], "488": ["Pre-NOTCH Processing in Golgi", "Reduction of cytosolic Ca++ levels", "Ion homeostasis", "Ion transport by P-type ATPases"], "4880": ["Physiological factors"], "4881": ["Physiological factors"], "4882": ["Physiological factors"], "4886": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "4887": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "4889": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "489": ["Pre-NOTCH Processing in Golgi", "Reduction of cytosolic Ca++ levels", "Ion homeostasis", "Ion transport by P-type ATPases"], "4891": ["Metal ion SLC transporters", "Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1)", "Iron uptake and transport"], "4893": ["SOS-mediated signalling", "Activation of RAS in B cells", "Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "SHC1 events in ERBB2 signaling", "SHC1 events in ERBB4 signaling", "Signaling by SCF-KIT", "Signalling to RAS", "p38MAPK events", "p38MAPK events", "GRB2 events in EGFR signaling", "SHC1 events in EGFR signaling", "Downstream signal transduction", "GRB2 events in ERBB2 signaling", "GRB2 events in ERBB2 signaling", "Tie2 Signaling", "EGFR Transactivation by Gastrin", "DAP12 signaling", "SHC-related events triggered by IGF1R", "FCERI mediated MAPK activation", "NCAM signaling for neurite out-growth", "Ras activation upon Ca2+ influx through NMDA receptor", "VEGFR2 mediated cell proliferation", "CD209 (DC-SIGN) signaling", "Constitutive Signaling by EGFRvIII", "SHC-mediated cascade:FGFR1", "FRS-mediated FGFR1 signaling", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "Signaling by FGFR2 in disease", "Signaling by FGFR4 in disease", "Signaling by FGFR1 in disease", "Regulation of RAS by GAPs", "RAF activation", "RAF/MAP kinase cascade", "MAP2K and MAPK activation", "Negative regulation of MAPK pathway", "Neutrophil degranulation", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "RAS signaling downstream of NF1 loss-of-function variants", "Paradoxical activation of RAF signaling by kinase inactive BRAF", "Insulin receptor signalling cascade", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "MET activates RAS signaling", "Signaling by FGFR3 fusions in cancer", "Signaling by FGFR3 point mutants in cancer", "Activated NTRK2 signals through RAS", "Erythropoietin activates RAS", "Activated NTRK2 signals through FRS2 and FRS3", "Activated NTRK3 signals through RAS"], "4897": ["Interaction between L1 and Ankyrins", "NrCAM interactions", "Neurofascin interactions"], "4899": ["PPARA activates gene expression", "Transcriptional activation of mitochondrial biogenesis", "Transcriptional activation of mitochondrial biogenesis"], "49": ["Acrosome Reaction"], "490": ["Reduction of cytosolic Ca++ levels", "Ion homeostasis", "Ion transport by P-type ATPases"], "4900": ["Long-term potentiation", "Long-term potentiation"], "4902": ["NCAM1 interactions", "RAF/MAP kinase cascade", "RET signaling"], "4904": ["mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "Noncanonical activation of NOTCH3"], "4905": ["COPII-mediated vesicle transport", "Trafficking of GluR2-containing AMPA receptors", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network"], "4907": ["Nicotinate metabolism", "Pyrimidine catabolism", "Purine catabolism"], "4908": ["NTF3 activates NTRK2 (TRKB) signaling", "NTF3 activates NTRK3 signaling", "NTF3 activates NTRK3 signaling", "Signaling by NTRK3 (TRKC)", "Activated NTRK3 signals through PLCG1", "Activated NTRK3 signals through PLCG1", "Activated NTRK3 signals through RAS", "Activated NTRK3 signals through PI3K", "Activated NTRK3 signals through PI3K"], "4909": ["NTF4 activates NTRK2 (TRKB) signaling", "Activated NTRK2 signals through RAS", "Activated NTRK2 signals through PLCG1", "Activated NTRK2 signals through PLCG1", "Activated NTRK2 signals through PI3K", "Activated NTRK2 signals through FRS2 and FRS3", "Activated NTRK2 signals through FRS2 and FRS3"], "491": ["Reduction of cytosolic Ca++ levels", "Ion homeostasis", "Ion transport by P-type ATPases"], "4913": ["Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "Cleavage of the damaged pyrimidine ", "Displacement of DNA glycosylase by APEX1"], "4914": ["PLC-gamma1 signalling", "Signalling to RAS", "Frs2-mediated activation", "Frs2-mediated activation", "ARMS-mediated activation", "ARMS-mediated activation", "Retrograde neurotrophin signalling", "Retrograde neurotrophin signalling", "NGF-independant TRKA activation", "TRKA activation by NGF", "TRKA activation by NGF", "Signalling to p38 via RIT and RIN", "PI3K/AKT activation", "PI3K/AKT activation", "Signalling to STAT3"], "4915": ["NGF-independant TRKA activation", "BDNF activates NTRK2 (TRKB) signaling", "NTF3 activates NTRK2 (TRKB) signaling", "NTF4 activates NTRK2 (TRKB) signaling", "Activated NTRK2 signals through RAS", "Activated NTRK2 signals through PLCG1", "Activated NTRK2 signals through PLCG1", "Activated NTRK2 signals through PI3K", "Activated NTRK2 signals through FRS2 and FRS3", "Activated NTRK2 signals through FRS2 and FRS3", "Activated NTRK2 signals through FYN", "NTRK2 activates RAC1", "NTRK2 activates RAC1", "Activated NTRK2 signals through CDK5"], "4916": ["Receptor-type tyrosine-protein phosphatases", "NTF3 activates NTRK3 signaling", "NTF3 activates NTRK3 signaling", "Signaling by NTRK3 (TRKC)", "Activated NTRK3 signals through PLCG1", "Activated NTRK3 signals through PLCG1", "Activated NTRK3 signals through RAS", "Activated NTRK3 signals through PI3K", "Activated NTRK3 signals through PI3K", "NTRK3 as a dependence receptor"], "4917": ["CDO in myogenesis"], "4919": ["WNT5A-dependent internalization of FZD2, FZD5 and ROR2"], "492": ["Reduction of cytosolic Ca++ levels", "Ion homeostasis", "Ion transport by P-type ATPases"], "4920": ["PCP/CE pathway", "WNT5A-dependent internalization of FZD2, FZD5 and ROR2"], "4921": ["Non-integrin membrane-ECM interactions"], "4922": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "4923": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "4924": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "4926": ["Recruitment of NuMA to mitotic centrosomes", "Mitotic Prophase"], "4927": ["ISG15 antiviral mechanism", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "tRNA processing in the nucleus"], "4928": ["ISG15 antiviral mechanism", "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "RHO GTPases Activate Formins", "tRNA processing in the nucleus", "Mitotic Prometaphase"], "4929": ["Nuclear Receptor transcription pathway", "SUMOylation of intracellular receptors"], "493": ["Reduction of cytosolic Ca++ levels", "Ion homeostasis", "Ion transport by P-type ATPases"], "4935": ["Amine ligand-binding receptors", "G alpha (q) signalling events"], "4938": ["Interferon gamma signaling", "OAS antiviral response", "Interferon alpha/beta signaling"], "493829": ["Smooth Muscle Contraction", "Smooth Muscle Contraction"], "493861": ["SUMOylation of DNA damage response and repair proteins"], "493869": ["Detoxification of Reactive Oxygen Species"], "4939": ["Interferon gamma signaling", "OAS antiviral response", "Interferon alpha/beta signaling"], "4940": ["Interferon gamma signaling", "OAS antiviral response", "Interferon alpha/beta signaling"], "494143": ["Glutathione synthesis and recycling"], "4942": ["Amino acid synthesis and interconversion (transamination)"], "4943": ["TBC/RABGAPs"], "4946": ["Regulation of ornithine decarboxylase (ODC)"], "4947": ["Regulation of ornithine decarboxylase (ODC)"], "4948": ["Melanin biosynthesis"], "495": ["Ion transport by P-type ATPases"], "4952": ["Synthesis of PIPs at the plasma membrane", "Synthesis of PIPs at the Golgi membrane", "Synthesis of IP2, IP, and Ins in the cytosol", "Synthesis of IP3 and IP4 in the cytosol", "Rho GTPase cycle", "Golgi Associated Vesicle Biogenesis", "Clathrin-mediated endocytosis"], "4953": ["Regulation of ornithine decarboxylase (ODC)", "Metabolism of polyamines"], "4957": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "4958": ["Keratan sulfate biosynthesis", "Keratan sulfate degradation", "Defective CHST6 causes MCDC1", "Defective ST3GAL3 causes MCT12 and EIEE15", "Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)"], "496": ["Ion transport by P-type ATPases"], "4961494": ["Caspase activation via Death Receptors in the presence of ligand"], "4967": ["Glyoxylate metabolism and glycine degradation", "Lysine catabolism", "Citric acid cycle (TCA cycle)"], "4968": ["Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "Cleavage of the damaged pyrimidine ", "Recognition and association of DNA glycosylase with site containing an affected purine", "Cleavage of the damaged purine", "Displacement of DNA glycosylase by APEX1", "APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway"], "4969": ["Keratan sulfate biosynthesis", "Keratan sulfate degradation", "Defective CHST6 causes MCDC1", "Defective ST3GAL3 causes MCT12 and EIEE15", "Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)"], "4973": ["Cell surface interactions at the vascular wall", "Neutrophil degranulation"], "4974": ["Axonal growth inhibition (RHOA activation)"], "4976": ["Regulation of Apoptosis"], "4978": ["Post-translational modification: synthesis of GPI-anchored proteins"], "498": ["Mitochondrial protein import", "Formation of ATP by chemiosmotic coupling", "Cristae formation"], "4982": ["TNFs bind their physiological receptors"], "4983": ["Rho GTPase cycle"], "4985": ["Peptide ligand-binding receptors", "G alpha (i) signalling events", "Interleukin-4 and Interleukin-13 signaling"], "4986": ["Peptide ligand-binding receptors", "G alpha (i) signalling events", "MECP2 regulates neuronal receptors and channels"], "49861": ["Tight junction interactions"], "4987": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "4988": ["Opioid Signalling", "G-protein activation", "Peptide ligand-binding receptors", "G alpha (i) signalling events", "Interleukin-4 and Interleukin-13 signaling", "MECP2 regulates neuronal receptors and channels"], "4991": ["Olfactory Signaling Pathway"], "4992": ["Olfactory Signaling Pathway"], "4993": ["Olfactory Signaling Pathway"], "4994": ["Olfactory Signaling Pathway"], "4995": ["Olfactory Signaling Pathway"], "4998": ["E2F-enabled inhibition of pre-replication complex formation", "Activation of ATR in response to replication stress", "Activation of E2F1 target genes at G1/S", "Assembly of the ORC complex at the origin of replication", "CDC6 association with the ORC:origin complex", "CDT1 association with the CDC6:ORC:origin complex", "Assembly of the pre-replicative complex", "Orc1 removal from chromatin", "Activation of the pre-replicative complex"], "4999": ["E2F-enabled inhibition of pre-replication complex formation", "Activation of ATR in response to replication stress", "Assembly of the ORC complex at the origin of replication", "CDC6 association with the ORC:origin complex", "CDT1 association with the CDC6:ORC:origin complex", "Assembly of the pre-replicative complex", "Orc1 removal from chromatin", "Activation of the pre-replicative complex"], "50": ["Mitochondrial protein import", "Citric acid cycle (TCA cycle)"], "5000": ["E2F-enabled inhibition of pre-replication complex formation", "Activation of ATR in response to replication stress", "Assembly of the ORC complex at the origin of replication", "CDC6 association with the ORC:origin complex", "CDT1 association with the CDC6:ORC:origin complex", "Assembly of the pre-replicative complex", "Orc1 removal from chromatin", "Activation of the pre-replicative complex"], "5001": ["E2F-enabled inhibition of pre-replication complex formation", "Activation of ATR in response to replication stress", "Assembly of the ORC complex at the origin of replication", "CDC6 association with the ORC:origin complex", "CDT1 association with the CDC6:ORC:origin complex", "Assembly of the pre-replicative complex", "Orc1 removal from chromatin", "Activation of the pre-replicative complex"], "5002": ["Organic cation transport", "Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1)"], "5004": ["Platelet degranulation ", "Neutrophil degranulation"], "5005": ["Platelet degranulation ", "Neutrophil degranulation"], "5007": ["Sphingolipid de novo biosynthesis", "Synthesis of bile acids and bile salts"], "5008": ["Interleukin-4 and Interleukin-13 signaling", "IL-6-type cytokine receptor ligand interactions"], "5009": ["Mitochondrial protein import", "Mitochondrial protein import", "Urea cycle"], "501": ["Choline catabolism", "Lysine catabolism"], "5010": ["Tight junction interactions"], "5016": ["Interaction With The Zona Pellucida"], "5018": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "5019": ["Utilization of Ketone Bodies"], "5020": ["Vasopressin-like receptors", "G alpha (q) signalling events"], "5021": ["Vasopressin-like receptors", "G alpha (q) signalling events"], "5023": ["Elevation of cytosolic Ca2+ levels", "Platelet homeostasis", "Neutrophil degranulation"], "5024": ["Elevation of cytosolic Ca2+ levels", "Platelet homeostasis"], "5025": ["Elevation of cytosolic Ca2+ levels", "Platelet homeostasis"], "5026": ["Elevation of cytosolic Ca2+ levels", "Platelet homeostasis"], "5027": ["Elevation of cytosolic Ca2+ levels", "Platelet homeostasis", "The NLRP3 inflammasome", "The NLRP3 inflammasome"], "5028": ["G alpha (q) signalling events", "P2Y receptors", "ADP signalling through P2Y purinoceptor 1", "ADP signalling through P2Y purinoceptor 1"], "5029": ["G alpha (q) signalling events", "P2Y receptors", "Surfactant metabolism"], "5030": ["P2Y receptors", "G alpha (i) signalling events"], "5031": ["G alpha (q) signalling events", "P2Y receptors"], "5032": ["G alpha (q) signalling events", "P2Y receptors", "G alpha (s) signalling events"], "5033": ["Collagen biosynthesis and modifying enzymes"], "5034": ["Collagen biosynthesis and modifying enzymes", "Detoxification of Reactive Oxygen Species", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Hedgehog ligand biogenesis", "VLDL assembly", "Post-translational protein phosphorylation", "Chylomicron assembly", "Interleukin-12 signaling", "Interleukin-23 signaling"], "503542": ["Post-translational modification: synthesis of GPI-anchored proteins"], "5036": ["Neutrophil degranulation"], "503614": ["Beta defensins", "Defensins"], "503618": ["Beta defensins", "Defensins"], "5037": ["MAP2K and MAPK activation", "Negative regulation of MAPK pathway", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF"], "503841": ["Beta defensins", "Defensins"], "504180": ["Beta defensins", "Defensins"], "504190": ["Olfactory Signaling Pathway"], "5045": ["Signaling by NODAL", "Collagen degradation", "Collagen degradation", "Elastic fibre formation", "Activation of Matrix Metalloproteinases", "Removal of aminoterminal propeptides from gamma-carboxylated proteins", "NGF processing", "Synthesis and processing of ENV and VPU", "Signaling by PDGF", "Pre-NOTCH Processing in Golgi", "TGF-beta receptor signaling activates SMADs", "Uptake and function of anthrax toxins", "Formation of the cornified envelope", "Assembly of active LPL and LIPC lipase complexes", "Amyloid fiber formation"], "5046": ["Signaling by NODAL", "NGF processing", "Formation of the cornified envelope", "Assembly of active LPL and LIPC lipase complexes"], "5048": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "RHO GTPases Activate Formins", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "AURKA Activation by TPX2"], "50484": ["Interconversion of nucleotide di- and triphosphates", "TP53 Regulates Metabolic Genes"], "50486": ["PPARA activates gene expression"], "50487": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PE", "Acyl chain remodelling of PG"], "50488": ["Oxidative Stress Induced Senescence"], "50489": ["Cross-presentation of soluble exogenous antigens (endosomes)", "Cross-presentation of soluble exogenous antigens (endosomes)"], "5049": ["Neutrophil degranulation", "COPI-independent Golgi-to-ER retrograde traffic"], "5050": ["COPI-independent Golgi-to-ER retrograde traffic"], "50506": ["Thyroxine biosynthesis"], "50507": ["Detoxification of Reactive Oxygen Species"], "50508": ["RHO GTPases Activate NADPH Oxidases"], "50509": ["Collagen degradation", "Extracellular matrix organization", "Collagen biosynthesis and modifying enzymes", "Signaling by PDGF", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "Syndecan interactions", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "NCAM1 interactions", "MET activates PTK2 signaling", "Collagen chain trimerization"], "5051": ["Platelet homeostasis"], "50511": ["Meiotic synapsis"], "50512": ["Cytosolic sulfonation of small molecules"], "50515": ["Chondroitin sulfate biosynthesis"], "5052": ["Detoxification of Reactive Oxygen Species", "TP53 Regulates Metabolic Genes", "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models"], "5053": ["Phenylketonuria", "Phenylalanine and tyrosine catabolism"], "5054": ["Platelet degranulation ", "BMAL1:CLOCK,NPAS2 activates circadian gene expression", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "ECM proteoglycans", "Dissolution of Fibrin Clot"], "5055": ["Dissolution of Fibrin Clot", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "5058": ["Generation of second messenger molecules", "Regulation of actin dynamics for phagocytic cup formation", "FCERI mediated MAPK activation", "FCERI mediated MAPK activation", "DSCAM interactions", "CD28 dependent Vav1 pathway", "EPHB-mediated forward signaling", "Ephrin signaling", "Sema3A PAK dependent Axon repulsion", "Activation of RAC1", "Signal transduction by L1", "Smooth Muscle Contraction", "VEGFR2 mediated vascular permeability", "CD209 (DC-SIGN) signaling", "RHO GTPases activate PKNs", "RHO GTPases Activate ROCKs", "RHO GTPases activate PAKs", "RHO GTPases activate PAKs", "MAPK6/MAPK4 signaling", "G beta:gamma signalling through CDC42"], "506": ["Mitochondrial protein import", "Mitochondrial protein import", "Formation of ATP by chemiosmotic coupling", "Transcriptional activation of mitochondrial biogenesis", "Cristae formation"], "50604": ["Interleukin-20 family signaling"], "50614": ["O-linked glycosylation of mucins"], "50615": ["Interleukin-21 signaling"], "50616": ["Interleukin-20 family signaling"], "50617": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "50618": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "5062": ["Nef and signal transduction", "Generation of second messenger molecules", "Regulation of PAK-2p34 activity by PS-GAP/RHG10", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Stimulation of the cell death response by PAK-2p34", "FCERI mediated MAPK activation", "FCERI mediated MAPK activation", "CD28 dependent Vav1 pathway", "Ephrin signaling", "Sema3A PAK dependent Axon repulsion", "Activation of RAC1", "VEGFA-VEGFR2 Pathway", "Smooth Muscle Contraction", "VEGFR2 mediated vascular permeability", "CD209 (DC-SIGN) signaling", "RHO GTPases activate PAKs", "RHO GTPases activate PAKs", "MAPK6/MAPK4 signaling", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "50628": ["snRNP Assembly"], "5063": ["Generation of second messenger molecules", "CD28 dependent Vav1 pathway", "Ephrin signaling", "Sema3A PAK dependent Axon repulsion", "Activation of RAC1", "VEGFR2 mediated vascular permeability", "CD209 (DC-SIGN) signaling", "RHO GTPases activate PAKs", "RHO GTPases activate PAKs", "MAPK6/MAPK4 signaling"], "50636": ["Stimuli-sensing channels"], "50640": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PE"], "50649": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "50650": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "5067": ["Post-translational modification: synthesis of GPI-anchored proteins"], "50674": ["Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells"], "5068": ["Antimicrobial peptides"], "5069": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "50700": ["The canonical retinoid cycle in rods (twilight vision)"], "5071": ["Pink/Parkin Mediated Mitophagy", "Josephin domain DUBs", "Amyloid fiber formation", "Antigen processing: Ubiquitination & Proteasome degradation"], "50717": ["Neddylation"], "5073": ["ATF4 activates genes", "Deadenylation of mRNA", "KSRP (KHSRP) binds and destabilizes mRNA"], "5077": ["HATs acetylate histones"], "5078": ["Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells"], "5079": ["RUNX1 regulates transcription of genes involved in BCR signaling"], "5080": ["Regulation of gene expression in beta cells", "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)", "Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "50801": ["TWIK related potassium channel (TREK)", "Phase 4 - resting membrane potential"], "50807": ["VxPx cargo-targeting to cilium", "VxPx cargo-targeting to cilium"], "50808": ["Factors involved in megakaryocyte development and platelet production"], "50813": ["DNA Damage Recognition in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Cargo recognition for clathrin-mediated endocytosis", "Neddylation"], "50814": ["Cholesterol biosynthesis"], "5082": ["Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "50831": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "50832": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "50833": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "50834": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "50835": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "50836": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "50837": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "50838": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "50839": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "50840": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "50846": ["Class B/2 (Secretin family receptors)", "Hedgehog ligand biogenesis", "Release of Hh-Np from the secreting cell", "Release of Hh-Np from the secreting cell", "Ligand-receptor interactions", "Ligand-receptor interactions", "Hedgehog 'on' state", "Activation of SMO", "HHAT G278V abrogates palmitoylation of Hh-Np"], "50848": ["Cell surface interactions at the vascular wall", "Integrin cell surface interactions", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "Tight junction interactions"], "50852": ["PIP3 activates AKT signaling", "Downstream TCR signaling", "Constitutive Signaling by Aberrant PI3K in Cancer", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "50855": ["TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "Tight junction interactions", "Asymmetric localization of PCP proteins"], "50856": ["Dectin-2 family"], "50859": ["Activation of Matrix Metalloproteinases"], "50863": ["Post-translational modification: synthesis of GPI-anchored proteins"], "50865": ["G alpha (i) signalling events", "Formyl peptide receptors bind formyl peptides and many other ligands"], "5087": ["Transcriptional regulation of pluripotent stem cells", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "NOTCH3 Intracellular Domain Regulates Transcription"], "509": ["Formation of ATP by chemiosmotic coupling", "Cristae formation"], "5091": ["Biotin transport and metabolism", "Defective HLCS causes multiple carboxylase deficiency", "Gluconeogenesis"], "5092": ["Phenylalanine and tyrosine catabolism"], "5093": ["mRNA Splicing - Major Pathway", "Processing of Capped Intron-Containing Pre-mRNA"], "50937": ["CDO in myogenesis", "CDO in myogenesis", "Ligand-receptor interactions", "Activation of SMO"], "5094": ["mRNA Splicing - Major Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "Negative regulators of DDX58/IFIH1 signaling"], "50940": ["cGMP effects", "G alpha (s) signalling events"], "50943": ["RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "RUNX1 regulates transcription of genes involved in WNT signaling"], "50944": ["Neurexins and neuroligins", "Neurexins and neuroligins"], "5095": ["Biotin transport and metabolism", "Defective HLCS causes multiple carboxylase deficiency", "Propionyl-CoA catabolism"], "5096": ["Biotin transport and metabolism", "Defective HLCS causes multiple carboxylase deficiency", "Propionyl-CoA catabolism"], "50964": ["TCF dependent signaling in response to WNT", "Negative regulation of TCF-dependent signaling by WNT ligand antagonists"], "5099": ["Platelet degranulation "], "50999": ["WNT ligand biogenesis and trafficking"], "51": ["PPARA activates gene expression", "alpha-linolenic acid (ALA) metabolism", "Beta-oxidation of very long chain fatty acids", "Peroxisomal protein import", "Peroxisomal protein import", "TYSND1 cleaves peroxisomal proteins"], "51000": ["Transport and synthesis of PAPS", "Transport of nucleotide sugars"], "51001": ["Pink/Parkin Mediated Mitophagy"], "51002": ["tRNA modification in the nucleus and cytosol"], "51003": ["PPARA activates gene expression", "Generic Transcription Pathway", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "51004": ["Ubiquinol biosynthesis"], "51005": ["Synthesis of UDP-N-acetyl-glucosamine"], "51008": ["ALKBH3 mediated reversal of alkylation damage"], "51009": ["ABC-family proteins mediated transport", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Defective CFTR causes cystic fibrosis", "ER Quality Control Compartment (ERQC)"], "51010": ["ATF4 activates genes", "mRNA decay by 3' to 5' exoribonuclease", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "KSRP (KHSRP) binds and destabilizes mRNA", "Major pathway of rRNA processing in the nucleolus and cytosol"], "51013": ["ATF4 activates genes", "mRNA decay by 3' to 5' exoribonuclease", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "KSRP (KHSRP) binds and destabilizes mRNA", "Major pathway of rRNA processing in the nucleolus and cytosol"], "51014": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "51021": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "51023": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "51025": ["Mitochondrial protein import"], "51028": ["Endosomal Sorting Complex Required For Transport (ESCRT)"], "51035": ["N-glycan trimming in the ER and Calnexin/Calreticulin cycle"], "5104": ["Intrinsic Pathway of Fibrin Clot Formation", "Common Pathway of Fibrin Clot Formation"], "51046": ["Sialic acid metabolism", "N-Glycan antennae elongation"], "5105": ["Abacavir metabolism", "Transcriptional regulation of white adipocyte differentiation", "Gluconeogenesis", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes"], "51052": ["Peptide ligand-binding receptors"], "51053": ["CDT1 association with the CDC6:ORC:origin complex", "Activation of the pre-replicative complex"], "51058": ["Generic Transcription Pathway"], "5106": ["Gluconeogenesis"], "51065": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "51067": ["Mitochondrial tRNA aminoacylation"], "51069": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "51070": ["NOSIP mediated eNOS trafficking"], "51071": ["Neutrophil degranulation", "Pentose phosphate pathway"], "51072": ["ERBB2 Regulates Cell Motility"], "51073": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "51074": ["Formation of apoptosome", "Methionine salvage pathway", "Regulation of the apoptosome activity"], "51076": ["Ion transport by P-type ATPases"], "51077": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "51079": ["Respiratory electron transport", "Complex I biogenesis"], "5108": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "51081": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "51082": ["Cytosolic sensors of pathogen-associated DNA ", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase III Chain Elongation", "RNA Polymerase I Transcription Termination", "RNA Polymerase III Transcription Termination", "RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "51083": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "51084": ["Formation of xylulose-5-phosphate"], "51085": ["PKA-mediated phosphorylation of key metabolic factors", "PKA-mediated phosphorylation of key metabolic factors", "AMPK inhibits chREBP transcriptional activation activity", "ChREBP activates metabolic gene expression", "ChREBP activates metabolic gene expression", "PP2A-mediated dephosphorylation of key metabolic factors"], "51088": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "51091": ["Selenocysteine synthesis"], "51094": ["AMPK inhibits chREBP transcriptional activation activity", "AMPK inhibits chREBP transcriptional activation activity"], "51095": ["tRNA processing in the nucleus", "tRNA processing in the mitochondrion"], "51096": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "51097": ["Platelet degranulation "], "51098": ["Hedgehog 'off' state", "Intraflagellar transport", "Intraflagellar transport"], "51099": ["Triglyceride catabolism"], "5110": ["Protein repair"], "51102": ["Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA"], "51103": ["Complex I biogenesis"], "51106": ["Transcriptional activation of mitochondrial biogenesis", "rRNA modification in the mitochondrion"], "51107": ["Nuclear signaling by ERBB4", "Regulated proteolysis of p75NTR", "NRIF signals cell death from the nucleus", "Activated NOTCH1 Transmits Signal to the Nucleus", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "NOTCH2 Activation and Transmission of Signal to the Nucleus", "EPH-ephrin mediated repulsion of cells", "NOTCH3 Activation and Transmission of Signal to the Nucleus", "NOTCH4 Activation and Transmission of Signal to the Nucleus", "Noncanonical activation of NOTCH3", "Amyloid fiber formation"], "51109": ["The canonical retinoid cycle in rods (twilight vision)", "RA biosynthesis pathway", "Retinoid metabolism and transport"], "5111": ["Translesion synthesis by REV1", "Recognition of DNA damage by PCNA-containing replication complex", "Translesion Synthesis by POLH", "Transcription of E2F targets under negative control by DREAM complex", "Polymerase switching on the C-strand of the telomere", "Processive synthesis on the C-strand of the telomere", "Telomere C-strand (Lagging Strand) Synthesis", "Removal of the Flap Intermediate from the C-strand", "SUMOylation of DNA replication proteins", "Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "Activation of E2F1 target genes at G1/S", "PCNA-Dependent Long Patch Base Excision Repair", "Translesion synthesis by POLK", "Translesion synthesis by POLI", "Termination of translesion DNA synthesis", "HDR through Homologous Recombination (HRR)", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "Polymerase switching", "Removal of the Flap Intermediate", "Processive synthesis on the lagging strand", "E3 ubiquitin ligases ubiquitinate target proteins"], "51111": ["PKMTs methylate histone lysines"], "51112": ["RAB GEFs exchange GTP for GDP on RABs"], "51116": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "51118": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "51121": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "51122": ["Neddylation"], "51123": ["Generic Transcription Pathway"], "51125": ["Neutrophil degranulation"], "51127": ["Interferon gamma signaling"], "51128": ["Regulation of cholesterol biosynthesis by SREBP (SREBF)", "COPII-mediated vesicle transport", "MHC class II antigen presentation", "Cargo concentration in the ER", "Chylomicron assembly", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "51129": ["PPARA activates gene expression", "Transcriptional regulation of white adipocyte differentiation", "Assembly of active LPL and LIPC lipase complexes"], "51130": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "51132": ["Antigen processing: Ubiquitination & Proteasome degradation"], "51134": ["Anchoring of the basal body to the plasma membrane"], "51135": ["PIP3 activates AKT signaling", "MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "IRAK4 deficiency (TLR5)", "IRAK4 deficiency (TLR2/4)", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Interleukin-1 signaling", "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "MyD88 dependent cascade initiated on endosome", "MyD88 cascade initiated on plasma membrane"], "51138": ["DNA Damage Recognition in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Cargo recognition for clathrin-mediated endocytosis", "Neddylation"], "51141": ["Regulation of cholesterol biosynthesis by SREBP (SREBF)"], "51142": ["Mitochondrial protein import"], "51143": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "RHO GTPases Activate Formins", "Neutrophil degranulation", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase"], "51144": ["Androgen biosynthesis", "Synthesis of very long-chain fatty acyl-CoAs"], "51146": ["O-linked glycosylation of mucins"], "51147": ["HATs acetylate histones"], "51151": ["Melanin biosynthesis"], "51156": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "5116": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "51160": ["Budding and maturation of HIV virion", "Membrane binding and targetting of GAG proteins", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "51164": ["MHC class II antigen presentation", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic"], "51166": ["Lysine catabolism", "Tryptophan catabolism"], "51167": ["Erythrocytes take up carbon dioxide and release oxygen"], "51170": ["Estrogen biosynthesis"], "51171": ["Estrogen biosynthesis"], "51176": ["Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "Deactivation of the beta-catenin transactivating complex", "Ca2+ pathway", "Binding of TCF/LEF:CTNNB1 to target gene promoters", "Repression of WNT target genes", "Repression of WNT target genes", "RUNX3 regulates WNT signaling"], "51179": ["Peroxisomal lipid metabolism", "Peroxisomal protein import", "Peroxisomal protein import"], "5118": ["Collagen biosynthesis and modifying enzymes", "Crosslinking of collagen fibrils"], "51181": ["Formation of xylulose-5-phosphate", "Essential pentosuria"], "51182": ["Regulation of HSF1-mediated heat shock response"], "51191": ["ISG15 antiviral mechanism", "DDX58/IFIH1-mediated induction of interferon-alpha/beta", "Negative regulators of DDX58/IFIH1 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "51196": ["Synthesis of IP3 and IP4 in the cytosol"], "51201": ["Surfactant metabolism"], "51202": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "51204": ["TP53 Regulates Metabolic Genes", "Respiratory electron transport"], "51205": ["Synthesis of PA"], "51206": ["GPVI-mediated activation cascade", "Cell surface interactions at the vascular wall", "Platelet Adhesion to exposed collagen"], "51208": ["Tight junction interactions"], "51209": ["Neutrophil degranulation", "Retrograde transport at the Trans-Golgi-Network", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "51213": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA 3'-end processing"], "51218": ["Mitochondrial iron-sulfur cluster biogenesis"], "5122": ["Peptide hormone biosynthesis", "Insulin processing", "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)", "Synthesis, secretion, and deacylation of Ghrelin"], "51224": ["Formation of RNA Pol II elongation complex ", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "RNA Polymerase II Transcription Elongation"], "51226": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "51227": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "51228": ["Glycosphingolipid metabolism"], "51230": ["HATs acetylate histones", "Regulation of TP53 Degradation", "Regulation of TP53 Activity through Association with Co-factors", "Stabilization of p53"], "51231": ["ERKs are inactivated"], "51241": ["TP53 Regulates Metabolic Genes", "Respiratory electron transport"], "51246": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "51248": ["Biotin transport and metabolism", "Vitamin B5 (pantothenate) metabolism", "Transport of vitamins, nucleosides, and related molecules", "Ion influx/efflux at host-pathogen interface", "Ion transport by P-type ATPases"], "5125": ["NGF processing", "Assembly of active LPL and LIPC lipase complexes"], "51251": ["Pyrimidine catabolism"], "51253": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "51255": ["E3 ubiquitin ligases ubiquitinate target proteins"], "51256": ["TBC/RABGAPs"], "51258": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "51259": ["Anchoring of the basal body to the plasma membrane"], "5126": ["Insulin processing"], "51263": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "51264": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "51266": ["GPVI-mediated activation cascade"], "51268": ["Lysine catabolism", "Peroxisomal protein import", "Peroxisomal protein import"], "51271": ["Budding and maturation of HIV virion", "Membrane binding and targetting of GAG proteins", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "51272": ["COPI-mediated anterograde transport", "Intra-Golgi traffic"], "51276": ["Generic Transcription Pathway"], "51280": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "51284": ["Trafficking and processing of endosomal TLR", "Toll Like Receptor 7/8 (TLR7/8) Cascade", "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "MyD88 dependent cascade initiated on endosome"], "51287": ["Mitochondrial protein import"], "51289": ["G alpha (i) signalling events", "Relaxin receptors"], "51291": ["Rho GTPase cycle"], "51292": ["Purine salvage"], "51293": ["Cobalamin (Cbl, vitamin B12) transport and metabolism", "Defective CD320 causes methylmalonic aciduria"], "51295": ["MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "Complex I biogenesis", "TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "MyD88 cascade initiated on plasma membrane"], "51296": ["Proton/oligopeptide cotransporters"], "51297": ["Antimicrobial peptides"], "51299": ["Post-translational modification: synthesis of GPI-anchored proteins"], "513": ["Formation of ATP by chemiosmotic coupling", "Cristae formation"], "5130": ["Synthesis of PC"], "51300": ["Complex I biogenesis"], "51301": ["O-linked glycosylation of mucins"], "51302": ["Synthesis of bile acids and bile salts via 24-hydroxycholesterol", "Endogenous sterols"], "51305": ["TWIK-releated acid-sensitive K+ channel (TASK)", "Phase 4 - resting membrane potential"], "51306": ["Rho GTPase cycle"], "51308": ["Olfactory Signaling Pathway"], "51310": ["Iron uptake and transport", "Iron uptake and transport"], "51311": ["Trafficking and processing of endosomal TLR", "Toll Like Receptor 7/8 (TLR7/8) Cascade", "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "MyD88 dependent cascade initiated on endosome"], "51312": ["Mitochondrial iron-sulfur cluster biogenesis"], "51316": ["Neutrophil degranulation"], "51317": ["HDACs deacetylate histones", "Factors involved in megakaryocyte development and platelet production"], "51318": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "51320": ["Antigen processing: Ubiquitination & Proteasome degradation"], "51322": ["E3 ubiquitin ligases ubiquitinate target proteins"], "5133": ["PD-1 signaling"], "51330": ["TNFR2 non-canonical NF-kB pathway", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "51332": ["NCAM signaling for neurite out-growth", "NCAM signaling for neurite out-growth", "Interaction between L1 and Ankyrins", "Interaction between L1 and Ankyrins", "RAF/MAP kinase cascade", "COPI-mediated anterograde transport"], "51333": ["Generic Transcription Pathway"], "51339": ["Degradation of DVL"], "51340": ["mRNA Splicing - Major Pathway"], "51343": ["Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "Phosphorylation of Emi1", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6", "Cyclin A:Cdk2-associated events at S phase entry", "Antigen processing: Ubiquitination & Proteasome degradation"], "51348": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "51350": ["Keratinization", "Formation of the cornified envelope"], "5136": ["Cam-PDE 1 activation", "cGMP effects", "G alpha (s) signalling events"], "51360": ["Regulation of cholesterol biosynthesis by SREBP (SREBF)", "ATF6 (ATF6-alpha) activates chaperones", "CREB3 factors activate genes", "CREB3 factors activate genes", "Assembly of active LPL and LIPC lipase complexes"], "51362": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing"], "51363": ["Chondroitin sulfate biosynthesis"], "51365": ["Acyl chain remodelling of PS"], "51367": ["tRNA processing in the nucleus"], "51368": ["Platelet degranulation "], "5137": ["Cam-PDE 1 activation"], "51373": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "51377": ["Downregulation of TGF-beta receptor signaling", "UCH proteinases", "UCH proteinases"], "51378": ["Tie2 Signaling"], "5138": ["cGMP effects", "G alpha (s) signalling events"], "51380": ["Degradation of cysteine and homocysteine"], "51382": ["ROS, RNS production in phagocytes", "Neutrophil degranulation", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "51384": ["WNT ligand biogenesis and trafficking", "WNT ligand biogenesis and trafficking", "Class B/2 (Secretin family receptors)"], "51385": ["Generic Transcription Pathway"], "51386": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "51388": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "5139": ["cGMP effects", "G alpha (s) signalling events"], "51393": ["TRP channels"], "51397": ["Neddylation"], "51399": ["COPII-mediated vesicle transport", "Syndecan interactions", "RAB GEFs exchange GTP for GDP on RABs"], "514": ["Formation of ATP by chemiosmotic coupling", "Cristae formation"], "5140": ["PDE3B signalling", "PDE3B signalling", "cGMP effects", "G alpha (s) signalling events"], "51400": ["Cyclin A/B1/B2 associated events during G2/M transition"], "5141": ["DARPP-32 events", "G alpha (s) signalling events"], "51411": ["Neutrophil degranulation"], "51412": ["RMTs methylate histone arginines", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "5142": ["DARPP-32 events", "G alpha (s) signalling events"], "51421": ["Signaling by Hippo"], "51422": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Macroautophagy", "AMPK inhibits chREBP transcriptional activation activity", "AMPK inhibits chREBP transcriptional activation activity", "Import of palmitoyl-CoA into the mitochondrial matrix", "Activation of PPARGC1A (PGC-1alpha) by phosphorylation", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Regulation of TP53 Activity through Phosphorylation", "Activation of AMPK downstream of NMDARs"], "51426": ["Translesion synthesis by POLK", "Termination of translesion DNA synthesis", "HDR through Homologous Recombination (HRR)", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER"], "51428": ["STING mediated induction of host immune responses", "Regulation of innate immune responses to cytosolic DNA", "IRF3-mediated induction of type I IFN"], "51429": ["Golgi Associated Vesicle Biogenesis", "Clathrin-mediated endocytosis"], "5143": ["DARPP-32 events", "G alpha (s) signalling events"], "51433": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6", "Antigen processing: Ubiquitination & Proteasome degradation"], "51434": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6", "Antigen processing: Ubiquitination & Proteasome degradation"], "5144": ["DARPP-32 events", "G alpha (s) signalling events"], "51444": ["Antigen processing: Ubiquitination & Proteasome degradation"], "51447": ["Synthesis of IPs in the nucleus", "Interferon alpha/beta signaling"], "5145": ["Activation of the phototransduction cascade", "Activation of the phototransduction cascade", "Inactivation, recovery and regulation of the phototransduction cascade", "Ca2+ pathway", "Ca2+ pathway"], "51451": ["Cyclin A/B1/B2 associated events during G2/M transition"], "51455": ["Translesion synthesis by REV1", "Translesion synthesis by POLK", "Translesion synthesis by POLI", "Termination of translesion DNA synthesis"], "51458": ["Rhesus glycoproteins mediate ammonium transport."], "51465": ["Antigen processing: Ubiquitination & Proteasome degradation"], "51466": ["Generation of second messenger molecules", "Signaling by ROBO receptors", "Signaling by ROBO receptors", "RHO GTPases Activate Formins"], "5147": ["ARL13B-mediated ciliary trafficking of INPP5E"], "51471": ["Amyloid fiber formation"], "51477": ["Synthesis of IP2, IP, and Ins in the cytosol"], "51478": ["Cholesterol biosynthesis"], "5148": ["Activation of the phototransduction cascade", "Activation of the phototransduction cascade", "Inactivation, recovery and regulation of the phototransduction cascade", "Ca2+ pathway", "Ca2+ pathway"], "51493": ["tRNA processing in the nucleus"], "51495": ["Synthesis of very long-chain fatty acyl-CoAs"], "51497": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Abortive elongation of HIV-1 transcript in the absence of Tat", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "RNA Polymerase II Transcription Elongation"], "51499": ["TP53 Regulates Transcription of Genes Involved in Cytochrome C Release"], "515": ["Formation of ATP by chemiosmotic coupling", "Cristae formation"], "5150": ["G alpha (s) signalling events"], "51501": ["Regulation of HSF1-mediated heat shock response"], "51503": ["mRNA Splicing - Major Pathway"], "51504": ["Methylation", "tRNA modification in the nucleus and cytosol", "rRNA modification in the nucleus and cytosol", "Eukaryotic Translation Termination"], "5151": ["G alpha (s) signalling events"], "51510": ["Budding and maturation of HIV virion", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "51512": ["G2/M Checkpoints", "The role of GTSE1 in G2/M progression after G2 checkpoint"], "51514": ["Recognition of DNA damage by PCNA-containing replication complex", "Neddylation"], "51517": ["Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs"], "5152": ["cGMP effects"], "51520": ["SeMet incorporation into proteins", "Cytosolic tRNA aminoacylation"], "51523": ["Estrogen-dependent gene expression"], "51529": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6", "Antigen processing: Ubiquitination & Proteasome degradation"], "5153": ["Cam-PDE 1 activation", "cGMP effects", "G alpha (s) signalling events"], "51534": ["Budding and maturation of HIV virion", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "5154": ["Platelet degranulation ", "PIP3 activates AKT signaling", "Downstream signal transduction", "Signaling by PDGF", "Constitutive Signaling by Aberrant PI3K in Cancer", "Non-integrin membrane-ECM interactions", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "51540": ["Metabolism of ingested SeMet, Sec, MeSec into H2Se"], "51542": ["Retrograde transport at the Trans-Golgi-Network"], "51548": ["Pre-NOTCH Transcription and Translation", "Processing of DNA double-strand break ends"], "5155": ["Platelet degranulation ", "PIP3 activates AKT signaling", "Downstream signal transduction", "Signaling by PDGF", "Constitutive Signaling by Aberrant PI3K in Cancer", "Non-integrin membrane-ECM interactions", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "51552": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Synthesis of PIPs at the plasma membrane", "Neutrophil degranulation", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "51554": ["Chemokine receptors bind chemokines"], "5156": ["PIP3 activates AKT signaling", "Downstream signal transduction", "Signaling by PDGF", "Constitutive Signaling by Aberrant PI3K in Cancer", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "51560": ["COPI-independent Golgi-to-ER retrograde traffic", "Retrograde transport at the Trans-Golgi-Network", "TBC/RABGAPs", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "51561": ["Interleukin-4 and Interleukin-13 signaling", "Interleukin-23 signaling", "Interleukin-23 signaling"], "51562": ["HATs acetylate histones"], "51564": ["NOTCH1 Intracellular Domain Regulates Transcription", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "SUMOylation of DNA damage response and repair proteins", "Regulation of PTEN gene transcription"], "51567": ["Nonhomologous End-Joining (NHEJ)"], "51571": ["Platelet degranulation "], "51573": ["Glycerophospholipid catabolism"], "5158": ["Activation of the phototransduction cascade", "Activation of the phototransduction cascade", "Inactivation, recovery and regulation of the phototransduction cascade", "Ca2+ pathway", "Ca2+ pathway"], "51582": ["Regulation of ornithine decarboxylase (ODC)"], "51585": ["Cleavage of Growing Transcript in the Termination Region ", "RNA polymerase II transcribes snRNA genes", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "51586": ["PPARA activates gene expression", "Generic Transcription Pathway", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "51588": ["Vitamin D (calciferol) metabolism", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of transcription factors", "SUMOylation of ubiquitinylation proteins", "SUMOylation of transcription cofactors", "SUMOylation of SUMOylation proteins", "SUMOylation of intracellular receptors", "SUMOylation of intracellular receptors", "SUMOylation of DNA replication proteins", "SUMOylation of immune response proteins", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "G2/M DNA damage checkpoint"], "5159": ["PIP3 activates AKT signaling", "Downstream signal transduction", "Signaling by PDGF", "Constitutive Signaling by Aberrant PI3K in Cancer", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "51592": ["Downregulation of SMAD2/3:SMAD4 transcriptional activity"], "51593": ["RNA polymerase II transcribes snRNA genes", "mRNA Splicing - Major Pathway"], "51594": ["COPI-dependent Golgi-to-ER retrograde traffic"], "51599": ["LDL clearance", "VLDL clearance"], "516": ["Mitochondrial protein import", "Mitochondrial protein import", "Formation of ATP by chemiosmotic coupling", "Cristae formation"], "5160": ["Regulation of pyruvate dehydrogenase (PDH) complex", "Glyoxylate metabolism and glycine degradation", "Signaling by Retinoic Acid", "Pyruvate metabolism"], "51601": ["Glyoxylate metabolism and glycine degradation"], "51602": ["SUMOylation of RNA binding proteins", "rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "51604": ["Attachment of GPI anchor to uPAR"], "51605": ["tRNA modification in the nucleus and cytosol"], "51606": ["ROS, RNS production in phagocytes", "Nef Mediated CD4 Down-regulation", "Nef Mediated CD8 Down-regulation", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "5161": ["Regulation of pyruvate dehydrogenase (PDH) complex", "Glyoxylate metabolism and glycine degradation", "Signaling by Retinoic Acid", "Pyruvate metabolism"], "51611": ["Synthesis of diphthamide-EEF2"], "51616": ["HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "Ub-specific processing proteases", "RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "51619": ["Antigen processing: Ubiquitination & Proteasome degradation"], "5162": ["Regulation of pyruvate dehydrogenase (PDH) complex", "Glyoxylate metabolism and glycine degradation", "Signaling by Retinoic Acid", "Pyruvate metabolism"], "51622": ["RAB GEFs exchange GTP for GDP on RABs"], "51626": ["Intraflagellar transport"], "5163": ["Regulation of pyruvate dehydrogenase (PDH) complex", "Signaling by Retinoic Acid"], "51637": ["tRNA processing in the nucleus"], "51639": ["mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "5164": ["Regulation of pyruvate dehydrogenase (PDH) complex", "Signaling by Retinoic Acid"], "51642": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "51645": ["mRNA Splicing - Major Pathway"], "51646": ["Neutrophil degranulation"], "51647": ["Cytosolic iron-sulfur cluster assembly"], "51649": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "5165": ["Regulation of pyruvate dehydrogenase (PDH) complex", "Signaling by Retinoic Acid"], "51650": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "51651": ["Ub-specific processing proteases"], "51652": ["Budding and maturation of HIV virion", "Macroautophagy", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "51659": ["Unwinding of DNA", "Unwinding of DNA"], "5166": ["Regulation of pyruvate dehydrogenase (PDH) complex", "Signaling by Retinoic Acid"], "51660": ["Pyruvate metabolism"], "51665": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "51666": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "51667": ["Neddylation"], "51668": ["Intraflagellar transport", "Intraflagellar transport"], "5167": ["Vitamin B2 (riboflavin) metabolism", "Vitamin B5 (pantothenate) metabolism"], "51676": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "5168": ["Vitamin B5 (pantothenate) metabolism"], "51684": ["Degradation of GLI1 by the proteasome", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'off' state", "Hedgehog 'on' state"], "51686": ["Regulation of ornithine decarboxylase (ODC)"], "5169": ["Vitamin B5 (pantothenate) metabolism"], "51690": ["mRNA decay by 5' to 3' exoribonuclease", "mRNA decay by 5' to 3' exoribonuclease", "mRNA Splicing - Major Pathway"], "51691": ["mRNA Splicing - Major Pathway"], "51692": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA Derived from an Intronless Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "51693": ["COPII-mediated vesicle transport", "RAB GEFs exchange GTP for GDP on RABs"], "51699": ["WNT ligand biogenesis and trafficking"], "517": ["Formation of ATP by chemiosmotic coupling", "Cristae formation"], "5170": ["GPVI-mediated activation cascade", "GPVI-mediated activation cascade", "PIP3 activates AKT signaling", "Activation of AKT2", "Downstream TCR signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated NF-kB activation", "Integrin alphaIIb beta3 signaling", "CD28 dependent PI3K/Akt signaling", "G beta:gamma signalling through PI3Kgamma", "RSK activation", "VEGFR2 mediated vascular permeability", "VEGFR2 mediated cell proliferation", "CLEC7A (Dectin-1) signaling", "RHO GTPases activate PKNs", "Constitutive Signaling by AKT1 E17K in Cancer", "Regulation of TP53 Degradation"], "51700": ["Erythrocytes take up carbon dioxide and release oxygen"], "51701": ["Ca2+ pathway"], "51702": ["Chromatin modifying enzymes"], "51703": ["Synthesis of very long-chain fatty acyl-CoAs"], "51706": ["Platelet degranulation ", "Erythrocytes take up carbon dioxide and release oxygen"], "51715": ["RAB geranylgeranylation"], "51719": ["Energy dependent regulation of mTOR by LKB1-AMPK", "Neutrophil degranulation"], "5172": ["Multifunctional anion exchangers", "Defective SLC26A4 causes Pendred syndrome (PDS)"], "51720": ["Metalloprotease DUBs", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "G2/M DNA damage checkpoint"], "51725": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "51726": ["XBP1(S) activates chaperone genes"], "51727": ["Interconversion of nucleotide di- and triphosphates"], "51728": ["Cytosolic sensors of pathogen-associated DNA ", "RNA Polymerase III Chain Elongation", "RNA Polymerase III Transcription Termination", "RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "51729": ["mRNA Splicing - Major Pathway"], "5173": ["Opioid Signalling", "G-protein activation", "Peptide ligand-binding receptors", "G alpha (i) signalling events"], "51733": ["Pyrimidine catabolism"], "51734": ["Protein repair"], "51738": ["Peptide ligand-binding receptors", "G alpha (q) signalling events", "Synthesis, secretion, and deacylation of Ghrelin"], "51741": ["Nuclear signaling by ERBB4", "Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "Activation of the TFAP2 (AP-2) family of transcription factors"], "51742": ["HDACs deacetylate histones", "NoRC negatively regulates rRNA expression"], "51744": ["Cell surface interactions at the vascular wall"], "5175": ["Platelet degranulation ", "Cell surface interactions at the vascular wall", "PECAM1 interactions", "Integrin cell surface interactions", "Platelet sensitization by LDL", "Neutrophil degranulation"], "51750": ["Cytosolic iron-sulfur cluster assembly", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)"], "51752": ["Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "51755": ["TP53 Regulates Transcription of DNA Repair Genes"], "51761": ["Ion transport by P-type ATPases"], "51762": ["TBC/RABGAPs", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "51763": ["Synthesis of PIPs at the plasma membrane"], "51764": ["Glucagon signaling in metabolic regulation", "G-protein activation", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42"], "51765": ["Apoptotic cleavage of cellular proteins"], "51773": ["Deposition of new CENPA-containing nucleosomes at the centromere"], "51780": ["HDMs demethylate histones"], "5179": ["Peptide ligand-binding receptors", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "G alpha (i) signalling events", "Post-translational protein phosphorylation"], "518": ["Formation of ATP by chemiosmotic coupling", "Cristae formation"], "51802": ["Stimuli-sensing channels"], "51805": ["Ubiquinol biosynthesis"], "51806": ["Neutrophil degranulation"], "51807": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "Gap junction assembly", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Recruitment of NuMA to mitotic centrosomes", "Formation of tubulin folding intermediates by CCT/TriC", "Post-chaperonin tubulin folding pathway", "Recycling pathway of L1", "Recycling pathway of L1", "Cilium Assembly", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "Carboxyterminal post-translational modifications of tubulin", "Carboxyterminal post-translational modifications of tubulin", "Activation of AMPK downstream of NMDARs", "Kinesins"], "51808": ["snRNP Assembly", "RNA polymerase II transcribes snRNA genes"], "51809": ["O-linked glycosylation of mucins"], "51816": ["Surfactant metabolism", "Neutrophil degranulation"], "5187": ["Circadian Clock"], "5189": ["Peroxisomal protein import", "Peroxisomal protein import"], "5190": ["Peroxisomal protein import", "Peroxisomal protein import"], "5191": ["Peroxisomal protein import", "Peroxisomal protein import"], "5192": ["E3 ubiquitin ligases ubiquitinate target proteins", "Peroxisomal protein import", "Peroxisomal protein import"], "5193": ["E3 ubiquitin ligases ubiquitinate target proteins", "Peroxisomal protein import", "Peroxisomal protein import"], "5194": ["E3 ubiquitin ligases ubiquitinate target proteins", "Peroxisomal protein import", "Peroxisomal protein import"], "5195": ["E3 ubiquitin ligases ubiquitinate target proteins", "Peroxisomal protein import", "Peroxisomal protein import"], "5196": ["Platelet degranulation ", "Common Pathway of Fibrin Clot Formation", "Cell surface interactions at the vascular wall", "Chemokine receptors bind chemokines", "G alpha (i) signalling events", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"], "5197": ["Common Pathway of Fibrin Clot Formation", "Cell surface interactions at the vascular wall"], "5198": ["Purine ribonucleoside monophosphate biosynthesis"], "5199": ["Alternative complement activation", "Activation of C3 and C5", "Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins", "Neutrophil degranulation", "Regulation of Complement cascade"], "5201": ["Prefoldin mediated transfer of substrate to CCT/TriC"], "5202": ["Prefoldin mediated transfer of substrate to CCT/TriC"], "5203": ["Prefoldin mediated transfer of substrate to CCT/TriC"], "5204": ["Prefoldin mediated transfer of substrate to CCT/TriC"], "5205": ["Ion transport by P-type ATPases"], "5207": ["PKA-mediated phosphorylation of key metabolic factors", "PP2A-mediated dephosphorylation of key metabolic factors", "Glycolysis", "Glycolysis"], "5208": ["Glycolysis"], "5209": ["Glycolysis"], "521": ["Formation of ATP by chemiosmotic coupling", "Cristae formation"], "5210": ["Glycolysis"], "5211": ["Neutrophil degranulation", "Glycolysis"], "5213": ["Glycolysis"], "5214": ["Glycolysis"], "5216": ["Platelet degranulation ", "Signaling by ROBO receptors", "PCP/CE pathway", "RHO GTPases Activate Formins", "RHO GTPases Activate Formins"], "5217": ["Signaling by ROBO receptors", "RHO GTPases Activate Formins", "RHO GTPases Activate Formins"], "522": ["Formation of ATP by chemiosmotic coupling", "Cristae formation"], "5222": ["Surfactant metabolism"], "5223": ["Neutrophil degranulation", "Glycolysis", "Gluconeogenesis"], "5224": ["Glycolysis", "Gluconeogenesis"], "5226": ["Pentose phosphate pathway"], "5228": ["VEGF ligand-receptor interactions", "VEGF binds to VEGFR leading to receptor dimerization"], "523": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "5230": ["Glycolysis", "Gluconeogenesis"], "5232": ["Glycolysis", "Gluconeogenesis"], "5236": ["Glycogen synthesis", "Defective PGM1 causes PGM1-CDG (CDG1t)", "Neutrophil degranulation", "Glycogen breakdown (glycogenolysis)", "Galactose catabolism"], "5238": ["Synthesis of UDP-N-acetyl-glucosamine"], "5241": ["Nuclear signaling by ERBB4", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Nuclear Receptor transcription pathway", "SUMOylation of intracellular receptors", "Estrogen-dependent gene expression"], "5243": ["Abacavir transmembrane transport", "ABC-family proteins mediated transport"], "5244": ["PPARA activates gene expression", "ABC-family proteins mediated transport", "Defective ABCB4 causes progressive familial intrahepatic cholestasis 3, intrahepatic cholestasis of pregnancy 3 and gallbladder disease 1"], "5245": ["RAF activation", "Signaling by moderate kinase activity BRAF mutants", "Signaling by RAS mutants", "Paradoxical activation of RAF signaling by kinase inactive BRAF", "Processing of SMDT1"], "525": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "5252": ["PRC2 methylates histones and DNA"], "5253": ["HDMs demethylate histones"], "5255": ["Glycogen breakdown (glycogenolysis)", "Glycogen breakdown (glycogenolysis)"], "5256": ["Glycogen breakdown (glycogenolysis)"], "5257": ["Glycogen breakdown (glycogenolysis)", "Glycogen breakdown (glycogenolysis)"], "526": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "5260": ["Glycogen breakdown (glycogenolysis)", "Glycogen breakdown (glycogenolysis)"], "5261": ["Glycogen breakdown (glycogenolysis)"], "5264": ["Alpha-oxidation of phytanate", "Peroxisomal protein import", "Peroxisomal protein import", "TYSND1 cleaves peroxisomal proteins"], "5265": ["Platelet degranulation ", "COPII-mediated vesicle transport", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Cargo concentration in the ER", "Neutrophil degranulation", "Post-translational protein phosphorylation"], "5266": ["Antimicrobial peptides", "Formation of the cornified envelope"], "5267": ["Platelet degranulation "], "5269": ["Neutrophil degranulation", "Dissolution of Fibrin Clot"], "527": ["ROS, RNS production in phagocytes", "Neutrophil degranulation", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "5270": ["Intrinsic Pathway of Fibrin Clot Formation", "Common Pathway of Fibrin Clot Formation", "Dissolution of Fibrin Clot"], "5271": ["Dissolution of Fibrin Clot"], "5273": ["Neutrophil degranulation"], "5275": ["RUNX1 regulates transcription of genes involved in differentiation of keratinocytes"], "5277": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "5279": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "528": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "5281": ["Synthesis of glycosylphosphatidylinositol (GPI)", "Synthesis of glycosylphosphatidylinositol (GPI)"], "5283": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "5284": ["Neutrophil degranulation"], "5286": ["Synthesis of PIPs at the plasma membrane", "Synthesis of PIPs at the Golgi membrane", "Synthesis of PIPs at the early endosome membrane", "Synthesis of PIPs at the late endosome membrane", "Golgi Associated Vesicle Biogenesis", "Clathrin-mediated endocytosis"], "5287": ["Synthesis of PIPs at the plasma membrane"], "5288": ["Synthesis of PIPs at the plasma membrane", "Synthesis of PIPs at the Golgi membrane"], "5289": ["PI3K Cascade", "Macroautophagy", "Synthesis of PIPs at the Golgi membrane", "Synthesis of PIPs at the early endosome membrane", "Synthesis of PIPs at the late endosome membrane", "Toll Like Receptor 9 (TLR9) Cascade", "RHO GTPases Activate NADPH Oxidases"], "529": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "5290": ["PI3K Cascade", "IRS-mediated signalling", "GPVI-mediated activation cascade", "Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "PI3K events in ERBB4 signaling", "PIP3 activates AKT signaling", "Signaling by SCF-KIT", "Synthesis of PIPs at the plasma membrane", "GAB1 signalosome", "Signaling by cytosolic FGFR1 fusion mutants", "Downstream signal transduction", "PI3K events in ERBB2 signaling", "PI3K/AKT activation", "Downstream TCR signaling", "Role of phospholipids in phagocytosis", "Tie2 Signaling", "Constitutive Signaling by Aberrant PI3K in Cancer", "DAP12 signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Nephrin family interactions", "Costimulation by the CD28 family", "CD28 dependent PI3K/Akt signaling", "G alpha (q) signalling events", "VEGFA-VEGFR2 Pathway", "VEGFA-VEGFR2 Pathway", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "Constitutive Signaling by EGFRvIII", "PI-3K cascade:FGFR1", "PI-3K cascade:FGFR2", "PI-3K cascade:FGFR3", "PI-3K cascade:FGFR4", "Signaling by FGFR2 in disease", "Signaling by FGFR4 in disease", "Signaling by FGFR1 in disease", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "MET activates PI3K/AKT signaling", "Signaling by FGFR3 fusions in cancer", "Signaling by FGFR3 point mutants in cancer", "RET signaling", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "Activated NTRK2 signals through PI3K", "Interleukin receptor SHC signaling", "Regulation of signaling by CBL", "Regulation of signaling by CBL", "Activated NTRK3 signals through PI3K"], "5291": ["PI3K Cascade", "IRS-mediated signalling", "GPVI-mediated activation cascade", "PIP3 activates AKT signaling", "Synthesis of PIPs at the plasma membrane", "Downstream signal transduction", "PI3K/AKT activation", "Downstream TCR signaling", "Role of phospholipids in phagocytosis", "Tie2 Signaling", "Constitutive Signaling by Aberrant PI3K in Cancer", "DAP12 signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Nephrin family interactions", "VEGFA-VEGFR2 Pathway", "VEGFA-VEGFR2 Pathway", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "RET signaling", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "Interleukin receptor SHC signaling", "Regulation of signaling by CBL", "Regulation of signaling by CBL"], "5292": ["Interleukin-4 and Interleukin-13 signaling"], "5293": ["PIP3 activates AKT signaling", "Synthesis of PIPs at the plasma membrane", "Constitutive Signaling by Aberrant PI3K in Cancer", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "RET signaling", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "Interleukin receptor SHC signaling", "Regulation of signaling by CBL", "Regulation of signaling by CBL", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "5294": ["GPVI-mediated activation cascade", "Synthesis of PIPs at the plasma membrane", "G beta:gamma signalling through PI3Kgamma", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)"], "5295": ["PI3K Cascade", "IRS-mediated signalling", "GPVI-mediated activation cascade", "Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "PI3K events in ERBB4 signaling", "PIP3 activates AKT signaling", "Interleukin-7 signaling", "Interleukin-7 signaling", "Signaling by SCF-KIT", "Synthesis of PIPs at the plasma membrane", "GAB1 signalosome", "Signaling by cytosolic FGFR1 fusion mutants", "Downstream signal transduction", "PI3K events in ERBB2 signaling", "PI3K/AKT activation", "Downstream TCR signaling", "Role of phospholipids in phagocytosis", "Tie2 Signaling", "Constitutive Signaling by Aberrant PI3K in Cancer", "DAP12 signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Nephrin family interactions", "Costimulation by the CD28 family", "CD28 dependent PI3K/Akt signaling", "G alpha (q) signalling events", "GP1b-IX-V activation signalling", "VEGFA-VEGFR2 Pathway", "VEGFA-VEGFR2 Pathway", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "Constitutive Signaling by EGFRvIII", "PI-3K cascade:FGFR1", "PI-3K cascade:FGFR2", "PI-3K cascade:FGFR3", "PI-3K cascade:FGFR4", "Signaling by FGFR2 in disease", "Signaling by FGFR4 in disease", "Signaling by FGFR1 in disease", "Interleukin-4 and Interleukin-13 signaling", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "MET activates PI3K/AKT signaling", "Signaling by FGFR3 fusions in cancer", "Signaling by FGFR3 point mutants in cancer", "RET signaling", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "Activated NTRK2 signals through PI3K", "Interleukin receptor SHC signaling", "Regulation of signaling by CBL", "Regulation of signaling by CBL", "Activated NTRK3 signals through PI3K", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "5296": ["PI3K Cascade", "IRS-mediated signalling", "GPVI-mediated activation cascade", "PIP3 activates AKT signaling", "Interleukin-7 signaling", "Interleukin-7 signaling", "Signaling by SCF-KIT", "Synthesis of PIPs at the plasma membrane", "Downstream signal transduction", "Rho GTPase cycle", "PI3K/AKT activation", "Downstream TCR signaling", "Role of phospholipids in phagocytosis", "Tie2 Signaling", "Constitutive Signaling by Aberrant PI3K in Cancer", "DAP12 signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Nephrin family interactions", "Costimulation by the CD28 family", "CD28 dependent PI3K/Akt signaling", "G alpha (q) signalling events", "VEGFA-VEGFR2 Pathway", "VEGFA-VEGFR2 Pathway", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "RET signaling", "Interleukin receptor SHC signaling", "Regulation of signaling by CBL", "Regulation of signaling by CBL"], "5297": ["Synthesis of PIPs at the ER membrane", "Synthesis of PIPs at the Golgi membrane"], "5298": ["Synthesis of PIPs at the Golgi membrane"], "5300": ["ISG15 antiviral mechanism", "RHO GTPases Activate NADPH Oxidases", "Regulation of TP53 Activity through Phosphorylation", "PI5P Regulates TP53 Acetylation", "Negative regulators of DDX58/IFIH1 signaling"], "5304": ["Miscellaneous transport and binding events"], "5305": ["Synthesis of PIPs at the plasma membrane", "PI5P Regulates TP53 Acetylation", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Synthesis of PIPs in the nucleus"], "5306": ["Role of second messengers in netrin-1 signaling", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "5308": ["TFAP2 (AP-2) family regulates transcription of other transcription factors"], "5310": ["VxPx cargo-targeting to cilium", "VxPx cargo-targeting to cilium"], "5311": ["VxPx cargo-targeting to cilium", "VxPx cargo-targeting to cilium"], "5313": ["ChREBP activates metabolic gene expression", "Regulation of gene expression in beta cells", "Glycolysis"], "5315": ["Neutrophil degranulation", "Glycolysis"], "5316": ["Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "5317": ["Apoptotic cleavage of cell adhesion proteins", "Neutrophil degranulation", "Keratinization", "Formation of the cornified envelope"], "5318": ["Keratinization", "Formation of the cornified envelope"], "5319": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PS", "Acyl chain remodelling of PE", "Acyl chain remodelling of PI", "Acyl chain remodelling of PG", "Synthesis of PA"], "5320": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PS", "Acyl chain remodelling of PE", "Acyl chain remodelling of PI", "Acyl chain remodelling of PG", "Synthesis of PA", "Antimicrobial peptides"], "5321": ["phospho-PLA2 pathway", "Acyl chain remodelling of PC", "Acyl chain remodeling of CL", "Acyl chain remodelling of PS", "Acyl chain remodelling of PE", "Acyl chain remodelling of PI", "Acyl chain remodelling of PG", "Hydrolysis of LPC", "Synthesis of PA", "Arachidonic acid metabolism", "ADP signalling through P2Y purinoceptor 1", "Platelet sensitization by LDL", "COPI-independent Golgi-to-ER retrograde traffic"], "5322": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PS", "Acyl chain remodelling of PE", "Acyl chain remodelling of PI", "Acyl chain remodelling of PG", "Synthesis of PA"], "5325": ["TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "5327": ["Signaling by PDGF", "Dissolution of Fibrin Clot"], "5328": ["Neutrophil degranulation", "Dissolution of Fibrin Clot"], "5329": ["Attachment of GPI anchor to uPAR", "Neutrophil degranulation", "Dissolution of Fibrin Clot"], "533": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "5330": ["PLC beta mediated events", "PLC beta mediated events", "Synthesis of IP3 and IP4 in the cytosol", "Acetylcholine regulates insulin secretion", "Acetylcholine regulates insulin secretion", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (q) signalling events", "G beta:gamma signalling through PLC beta", "Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "Presynaptic function of Kainate receptors"], "5331": ["PLC beta mediated events", "PLC beta mediated events", "Synthesis of IP3 and IP4 in the cytosol", "Acetylcholine regulates insulin secretion", "Acetylcholine regulates insulin secretion", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (q) signalling events", "G beta:gamma signalling through PLC beta", "Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "Presynaptic function of Kainate receptors"], "5332": ["PLC beta mediated events", "PLC beta mediated events", "Synthesis of IP3 and IP4 in the cytosol", "G alpha (q) signalling events", "G alpha (q) signalling events"], "5333": ["Synthesis of IP3 and IP4 in the cytosol"], "53339": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "53343": ["Phosphate bond hydrolysis by NUDT proteins"], "5335": ["ISG15 antiviral mechanism", "Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "PLCG1 events in ERBB2 signaling", "DAG and IP3 signaling", "PLC-gamma1 signalling", "Synthesis of IP3 and IP4 in the cytosol", "Downstream signal transduction", "Generation of second messenger molecules", "Role of phospholipids in phagocytosis", "Role of phospholipids in phagocytosis", "PECAM1 interactions", "EGFR interacts with phospholipase C-gamma", "DAP12 signaling", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "Role of second messengers in netrin-1 signaling", "VEGFR2 mediated cell proliferation", "VEGFR2 mediated cell proliferation", "Constitutive Signaling by EGFRvIII", "Phospholipase C-mediated cascade: FGFR1", "Phospholipase C-mediated cascade; FGFR2", "Phospholipase C-mediated cascade; FGFR3", "Phospholipase C-mediated cascade; FGFR4", "Signaling by FGFR2 in disease", "Signaling by FGFR4 in disease", "Signaling by FGFR1 in disease", "Signaling by FGFR3 point mutants in cancer", "RET signaling", "Activated NTRK2 signals through PLCG1", "Activated NTRK2 signals through PLCG1", "Erythropoietin activates Phospholipase C gamma (PLCG)", "Activated NTRK3 signals through PLCG1", "Activated NTRK3 signals through PLCG1"], "53354": ["Coenzyme A biosynthesis"], "53358": ["Signalling to RAS", "Signalling to RAS", "RAF/MAP kinase cascade", "RET signaling"], "5336": ["GPVI-mediated activation cascade", "Toll Like Receptor 4 (TLR4) Cascade", "Synthesis of IP3 and IP4 in the cytosol", "Role of phospholipids in phagocytosis", "DAP12 signaling", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "CLEC7A (Dectin-1) signaling", "CLEC7A (Dectin-1) signaling", "Dectin-2 family", "Dectin-2 family", "Erythropoietin activates Phospholipase C gamma (PLCG)", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "5337": ["Synthesis of PG", "Synthesis of PA", "Role of phospholipids in phagocytosis", "Neutrophil degranulation"], "53371": ["ISG15 antiviral mechanism", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "tRNA processing in the nucleus"], "53373": ["Stimuli-sensing channels"], "5338": ["Synthesis of PG", "Synthesis of PA", "Role of phospholipids in phagocytosis"], "5339": ["Assembly of collagen fibrils and other multimeric structures", "Caspase-mediated cleavage of cytoskeletal proteins", "Type I hemidesmosome assembly"], "534": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "5340": ["Platelet degranulation ", "Degradation of the extracellular matrix", "Degradation of the extracellular matrix", "Activation of Matrix Metalloproteinases", "Signaling by PDGF", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Dissolution of Fibrin Clot"], "53407": ["COPI-dependent Golgi-to-ER retrograde traffic"], "5341": ["Platelet degranulation "], "5345": ["Platelet degranulation ", "Dissolution of Fibrin Clot"], "5346": ["Triglyceride catabolism", "Transcriptional regulation of white adipocyte differentiation"], "5347": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Polo-like kinase mediated events", "Golgi Cisternae Pericentriolar Stack Reorganization", "Golgi Cisternae Pericentriolar Stack Reorganization", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Phosphorylation of the APC/C", "Phosphorylation of Emi1", "Condensation of Prophase Chromosomes", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Regulation of PLK1 Activity at G2/M Transition", "Activation of NIMA Kinases NEK9, NEK6, NEK7", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "RHO GTPases Activate Formins", "Mitotic Prometaphase", "Mitotic Metaphase/Anaphase Transition", "Mitotic Telophase/Cytokinesis", "Cyclin A/B1/B2 associated events during G2/M transition", "The role of GTSE1 in G2/M progression after G2 checkpoint", "AURKA Activation by TPX2"], "5348": ["Ion homeostasis", "Ion transport by P-type ATPases"], "5349": ["Ion homeostasis", "Ion transport by P-type ATPases"], "535": ["ROS, RNS production in phagocytes", "Neutrophil degranulation", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "5350": ["Ion homeostasis", "Ion transport by P-type ATPases"], "5351": ["Collagen biosynthesis and modifying enzymes"], "5352": ["Collagen biosynthesis and modifying enzymes"], "5356": ["mRNA Splicing - Major Pathway"], "5360": ["HDL remodeling"], "5361": ["Sema3A PAK dependent Axon repulsion", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "CRMPs in Sema3A signaling", "CRMPs in Sema3A signaling", "Other semaphorin interactions"], "53615": ["HDACs deacetylate histones", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "Regulation of TP53 Activity through Acetylation", "RNA Polymerase I Transcription Initiation", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription"], "53616": ["LGI-ADAM interactions"], "5362": ["Sema3A PAK dependent Axon repulsion", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "CRMPs in Sema3A signaling", "CRMPs in Sema3A signaling", "Other semaphorin interactions"], "53630": ["Retinoid metabolism and transport"], "53632": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Macroautophagy", "Activation of PPARGC1A (PGC-1alpha) by phosphorylation", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Regulation of TP53 Activity through Phosphorylation", "Activation of AMPK downstream of NMDARs"], "53637": ["G alpha (i) signalling events", "Lysosphingolipid and LPA receptors"], "5364": ["G alpha (12/13) signalling events", "Sema4D mediated inhibition of cell attachment and migration", "Sema4D induced cell migration and growth-cone collapse"], "5365": ["Other semaphorin interactions"], "5366": ["Activation of NOXA and translocation to mitochondria", "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release"], "5367": ["Peptide ligand-binding receptors", "G alpha (q) signalling events", "G alpha (i) signalling events"], "5368": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "537": ["Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "5371": ["SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Regulation of TP53 Activity through Acetylation", "Interferon gamma signaling", "Regulation of RUNX1 Expression and Activity", "Regulation of PTEN localization"], "5372": ["Synthesis of GDP-mannose"], "5373": ["Defective PMM2 causes PMM2-CDG (CDG-1a)", "Synthesis of GDP-mannose"], "538": ["Detoxification of Reactive Oxygen Species", "Ion influx/efflux at host-pathogen interface", "Ion transport by P-type ATPases"], "53822": ["Ion homeostasis", "Ion transport by P-type ATPases"], "53826": ["Ion homeostasis", "Ion transport by P-type ATPases"], "53828": ["Ion homeostasis", "Ion transport by P-type ATPases"], "53829": ["P2Y receptors", "G alpha (i) signalling events"], "53831": ["G alpha (s) signalling events", "Neutrophil degranulation"], "53832": ["Interleukin-20 family signaling"], "53833": ["Interleukin-20 family signaling"], "53834": ["FGFRL1 modulation of FGFR1 signaling"], "53840": ["Interferon gamma signaling"], "53842": ["Tight junction interactions"], "539": ["Formation of ATP by chemiosmotic coupling", "Cristae formation"], "53905": ["Thyroxine biosynthesis"], "53916": ["Neutrophil degranulation", "RAB geranylgeranylation", "MET receptor recycling"], "53917": ["Neutrophil degranulation", "RAB geranylgeranylation"], "53919": ["Transport of organic anions"], "5393": ["ATF4 activates genes", "mRNA decay by 3' to 5' exoribonuclease", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "KSRP (KHSRP) binds and destabilizes mRNA", "Major pathway of rRNA processing in the nucleolus and cytosol"], "53938": ["mRNA Splicing - Major Pathway"], "5394": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "53942": ["Post-translational modification: synthesis of GPI-anchored proteins"], "5395": ["Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "Defective Mismatch Repair Associated With MLH1", "Defective Mismatch Repair Associated With PMS2", "TP53 Regulates Transcription of DNA Repair Genes"], "53981": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA Derived from an Intronless Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "54": ["Vitamin B2 (riboflavin) metabolism"], "540": ["Ion transport by P-type ATPases"], "54014": ["Interleukin-7 signaling", "Interleukin-7 signaling", "Chromatin modifying enzymes"], "54020": ["Gluconeogenesis"], "5406": ["Digestion of dietary lipid", "Retinoid metabolism and transport"], "54069": ["Deposition of new CENPA-containing nucleosomes at the centromere"], "5407": ["Digestion of dietary lipid"], "5408": ["Digestion of dietary lipid"], "5409": ["Catecholamine biosynthesis"], "54106": ["PI3K Cascade", "Trafficking and processing of endosomal TLR", "Toll Like Receptor 9 (TLR9) Cascade", "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "MyD88 dependent cascade initiated on endosome"], "54107": ["Recognition of DNA damage by PCNA-containing replication complex", "Telomere C-strand synthesis initiation", "PCNA-Dependent Long Patch Base Excision Repair", "Termination of translesion DNA synthesis", "HDR through Homologous Recombination (HRR)", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "DNA replication initiation", "Activation of the pre-replicative complex"], "5414": ["Release of apoptotic factors from the mitochondria", "SMAC, XIAP-regulated apoptotic response"], "54148": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "54165": ["Neddylation"], "54187": ["Sialic acid metabolism"], "54205": ["Release of apoptotic factors from the mitochondria", "Formation of apoptosome", "Activation of caspases through apoptosome-mediated cleavage", "SMAC (DIABLO) binds to IAPs ", "SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ", "Transcriptional activation of mitochondrial biogenesis", "Detoxification of Reactive Oxygen Species", "TP53 Regulates Metabolic Genes", "Respiratory electron transport", "Regulation of the apoptosome activity", "Regulation of the apoptosome activity"], "54207": ["TWIK related potassium channel (TREK)", "Phase 4 - resting membrane potential"], "54209": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "DAP12 interactions", "DAP12 signaling", "DAP12 signaling", "Other semaphorin interactions"], "54210": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "DAP12 interactions"], "5422": ["Inhibition of replication initiation of damaged DNA by RB1/E2F1", "Polymerase switching on the C-strand of the telomere", "Telomere C-strand synthesis initiation", "Activation of E2F1 target genes at G1/S", "DNA replication initiation", "Activation of the pre-replicative complex", "Polymerase switching", "Removal of the Flap Intermediate", "Processive synthesis on the lagging strand"], "5423": ["POLB-Dependent Long Patch Base Excision Repair", "Resolution of AP sites via the multiple-nucleotide patch replacement pathway", "Resolution of AP sites via the single-nucleotide replacement pathway", "APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "PCNA-Dependent Long Patch Base Excision Repair", "Ub-specific processing proteases", "Abasic sugar-phosphate removal via the single-nucleotide replacement pathway"], "5424": ["Recognition of DNA damage by PCNA-containing replication complex", "Polymerase switching on the C-strand of the telomere", "Processive synthesis on the C-strand of the telomere", "Telomere C-strand (Lagging Strand) Synthesis", "Removal of the Flap Intermediate from the C-strand", "Cytosolic iron-sulfur cluster assembly", "Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "PCNA-Dependent Long Patch Base Excision Repair", "Termination of translesion DNA synthesis", "HDR through Homologous Recombination (HRR)", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Polymerase switching", "Removal of the Flap Intermediate", "Processive synthesis on the lagging strand"], "5425": ["Recognition of DNA damage by PCNA-containing replication complex", "Polymerase switching on the C-strand of the telomere", "Processive synthesis on the C-strand of the telomere", "Telomere C-strand (Lagging Strand) Synthesis", "Removal of the Flap Intermediate from the C-strand", "Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "PCNA-Dependent Long Patch Base Excision Repair", "Termination of translesion DNA synthesis", "HDR through Homologous Recombination (HRR)", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Polymerase switching", "Removal of the Flap Intermediate", "Processive synthesis on the lagging strand"], "5426": ["Recognition of DNA damage by PCNA-containing replication complex", "Telomere C-strand synthesis initiation", "PCNA-Dependent Long Patch Base Excision Repair", "Termination of translesion DNA synthesis", "HDR through Homologous Recombination (HRR)", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "DNA replication initiation", "Activation of the pre-replicative complex"], "5427": ["Recognition of DNA damage by PCNA-containing replication complex", "Telomere C-strand synthesis initiation", "PCNA-Dependent Long Patch Base Excision Repair", "Termination of translesion DNA synthesis", "HDR through Homologous Recombination (HRR)", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "DNA replication initiation", "Activation of the pre-replicative complex"], "5429": ["Translesion Synthesis by POLH", "Termination of translesion DNA synthesis", "HDR through Homologous Recombination (HRR)"], "5430": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Abortive elongation of HIV-1 transcript in the absence of Tat", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "Viral Messenger RNA Synthesis", "MicroRNA (miRNA) biogenesis", "Transcriptional regulation of pluripotent stem cells", "Transcriptional regulation by small RNAs", "PIWI-interacting RNA (piRNA) biogenesis", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE", "Signaling by FGFR2 IIIa TM", "Estrogen-dependent gene expression"], "5431": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Abortive elongation of HIV-1 transcript in the absence of Tat", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "Viral Messenger RNA Synthesis", "MicroRNA (miRNA) biogenesis", "Transcriptional regulation of pluripotent stem cells", "Transcriptional regulation by small RNAs", "PIWI-interacting RNA (piRNA) biogenesis", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE", "Signaling by FGFR2 IIIa TM", "Estrogen-dependent gene expression"], "5432": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Abortive elongation of HIV-1 transcript in the absence of Tat", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "Viral Messenger RNA Synthesis", "MicroRNA (miRNA) biogenesis", "Transcriptional regulation of pluripotent stem cells", "Transcriptional regulation by small RNAs", "PIWI-interacting RNA (piRNA) biogenesis", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE", "Signaling by FGFR2 IIIa TM", "Estrogen-dependent gene expression"], "5433": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Abortive elongation of HIV-1 transcript in the absence of Tat", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "Viral Messenger RNA Synthesis", "MicroRNA (miRNA) biogenesis", "Transcriptional regulation of pluripotent stem cells", "Transcriptional regulation by small RNAs", "PIWI-interacting RNA (piRNA) biogenesis", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE", "Signaling by FGFR2 IIIa TM", "Estrogen-dependent gene expression"], "54331": ["Activation of G protein gated Potassium channels", "Glucagon signaling in metabolic regulation", "G-protein activation", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42", "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "5434": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Abortive elongation of HIV-1 transcript in the absence of Tat", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "Viral Messenger RNA Synthesis", "Cytosolic sensors of pathogen-associated DNA ", "MicroRNA (miRNA) biogenesis", "NoRC negatively regulates rRNA expression", "Transcriptional regulation of pluripotent stem cells", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "PIWI-interacting RNA (piRNA) biogenesis", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase III Chain Elongation", "RNA Polymerase I Transcription Termination", "RNA Polymerase III Transcription Termination", "RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Pol II CTD phosphorylation and interaction with CE", "Signaling by FGFR2 IIIa TM", "Estrogen-dependent gene expression"], "54344": ["Synthesis of dolichyl-phosphate mannose", "Defective DPM3 causes DPM3-CDG (CDG-1o)"], "5435": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Abortive elongation of HIV-1 transcript in the absence of Tat", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "Viral Messenger RNA Synthesis", "Cytosolic sensors of pathogen-associated DNA ", "MicroRNA (miRNA) biogenesis", "NoRC negatively regulates rRNA expression", "Transcriptional regulation of pluripotent stem cells", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "PIWI-interacting RNA (piRNA) biogenesis", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase III Chain Elongation", "RNA Polymerase I Transcription Termination", "RNA Polymerase III Transcription Termination", "RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Pol II CTD phosphorylation and interaction with CE", "Signaling by FGFR2 IIIa TM", "Estrogen-dependent gene expression"], "5436": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Abortive elongation of HIV-1 transcript in the absence of Tat", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "Viral Messenger RNA Synthesis", "MicroRNA (miRNA) biogenesis", "Transcriptional regulation of pluripotent stem cells", "Transcriptional regulation by small RNAs", "PIWI-interacting RNA (piRNA) biogenesis", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE", "Signaling by FGFR2 IIIa TM", "Estrogen-dependent gene expression"], "54361": ["TCF dependent signaling in response to WNT", "WNT ligand biogenesis and trafficking", "WNT ligand biogenesis and trafficking", "Class B/2 (Secretin family receptors)", "Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "PCP/CE pathway", "PCP/CE pathway"], "54363": ["Glyoxylate metabolism and glycine degradation", "Peroxisomal protein import", "Peroxisomal protein import"], "5437": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Abortive elongation of HIV-1 transcript in the absence of Tat", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "Viral Messenger RNA Synthesis", "Cytosolic sensors of pathogen-associated DNA ", "MicroRNA (miRNA) biogenesis", "NoRC negatively regulates rRNA expression", "Transcriptional regulation of pluripotent stem cells", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "PIWI-interacting RNA (piRNA) biogenesis", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase III Chain Elongation", "RNA Polymerase I Transcription Termination", "RNA Polymerase III Transcription Termination", "RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Pol II CTD phosphorylation and interaction with CE", "Signaling by FGFR2 IIIa TM", "Estrogen-dependent gene expression"], "5438": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Abortive elongation of HIV-1 transcript in the absence of Tat", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "Viral Messenger RNA Synthesis", "MicroRNA (miRNA) biogenesis", "Transcriptional regulation of pluripotent stem cells", "Transcriptional regulation by small RNAs", "PIWI-interacting RNA (piRNA) biogenesis", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE", "Signaling by FGFR2 IIIa TM", "Estrogen-dependent gene expression"], "54386": ["Meiotic synapsis", "Packaging Of Telomere Ends", "DNA Damage/Telomere Stress Induced Senescence"], "5439": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Abortive elongation of HIV-1 transcript in the absence of Tat", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "Viral Messenger RNA Synthesis", "MicroRNA (miRNA) biogenesis", "Transcriptional regulation of pluripotent stem cells", "Transcriptional regulation by small RNAs", "PIWI-interacting RNA (piRNA) biogenesis", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE", "Signaling by FGFR2 IIIa TM", "Estrogen-dependent gene expression"], "5440": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Abortive elongation of HIV-1 transcript in the absence of Tat", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "Viral Messenger RNA Synthesis", "Cytosolic sensors of pathogen-associated DNA ", "MicroRNA (miRNA) biogenesis", "NoRC negatively regulates rRNA expression", "Transcriptional regulation of pluripotent stem cells", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "PIWI-interacting RNA (piRNA) biogenesis", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase III Chain Elongation", "RNA Polymerase I Transcription Termination", "RNA Polymerase III Transcription Termination", "RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Pol II CTD phosphorylation and interaction with CE", "Signaling by FGFR2 IIIa TM", "Estrogen-dependent gene expression"], "54407": ["Glutamate Neurotransmitter Release Cycle", "Amino acid transport across the plasma membrane"], "5441": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Abortive elongation of HIV-1 transcript in the absence of Tat", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "Viral Messenger RNA Synthesis", "Cytosolic sensors of pathogen-associated DNA ", "MicroRNA (miRNA) biogenesis", "NoRC negatively regulates rRNA expression", "Transcriptional regulation of pluripotent stem cells", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "PIWI-interacting RNA (piRNA) biogenesis", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase III Chain Elongation", "RNA Polymerase I Transcription Termination", "RNA Polymerase III Transcription Termination", "RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Pol II CTD phosphorylation and interaction with CE", "Signaling by FGFR2 IIIa TM", "Estrogen-dependent gene expression"], "54413": ["Neurexins and neuroligins", "Neurexins and neuroligins"], "5442": ["Mitochondrial transcription initiation", "Transcriptional activation of mitochondrial biogenesis"], "54429": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "5443": ["Opioid Signalling", "Androgen biosynthesis", "Glucocorticoid biosynthesis", "G-protein activation", "Peptide hormone biosynthesis", "Endogenous sterols", "Peptide ligand-binding receptors", "G alpha (s) signalling events", "G alpha (i) signalling events", "Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)", "Interleukin-4 and Interleukin-13 signaling", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes"], "54433": ["rRNA modification in the nucleus and cytosol"], "54437": ["Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "5444": ["Synthesis of 5-eicosatetraenoic acids"], "5445": ["Synthesis of 5-eicosatetraenoic acids"], "54453": ["RAB GEFs exchange GTP for GDP on RABs"], "54456": ["PIWI-interacting RNA (piRNA) biogenesis"], "54457": ["HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "5446": ["Synthesis of 5-eicosatetraenoic acids"], "54460": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "54461": ["Association of TriC/CCT with target proteins during biosynthesis", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "54464": ["mRNA decay by 5' to 3' exoribonuclease", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA"], "54469": ["Peroxisomal protein import", "Peroxisomal protein import"], "5447": ["Cytochrome P450 - arranged by substrate type"], "54472": ["Neutrophil degranulation", "Interleukin-1 signaling"], "54474": ["Keratinization", "Formation of the cornified envelope"], "54476": ["Negative regulators of DDX58/IFIH1 signaling"], "54477": ["Synthesis of PIPs at the plasma membrane"], "54480": ["Chondroitin sulfate biosynthesis"], "54482": ["tRNA modification in the nucleus and cytosol"], "54487": ["MicroRNA (miRNA) biogenesis", "Transcriptional Regulation by MECP2"], "54490": ["Glucuronidation"], "54492": ["Activated NOTCH1 Transmits Signal to the Nucleus", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "NOTCH2 Activation and Transmission of Signal to the Nucleus", "NOTCH3 Activation and Transmission of Signal to the Nucleus"], "54495": ["Platelet degranulation "], "54496": ["RMTs methylate histone arginines"], "54498": ["PAOs oxidise polyamines to amines", "Interconversion of polyamines"], "545": ["Meiotic synapsis", "Activation of ATR in response to replication stress", "Regulation of HSF1-mediated heat shock response", "HDR through Single Strand Annealing (SSA)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Fanconi Anemia Pathway", "TP53 Regulates Transcription of DNA Repair Genes", "Regulation of TP53 Activity through Phosphorylation", "G2/M DNA damage checkpoint"], "54507": ["Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "54509": ["Rho GTPase cycle", "Neutrophil degranulation"], "5451": ["Interleukin-4 and Interleukin-13 signaling", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "Estrogen-dependent gene expression"], "54511": ["Synthesis of Ketone Bodies"], "54512": ["ATF4 activates genes", "mRNA decay by 3' to 5' exoribonuclease", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "KSRP (KHSRP) binds and destabilizes mRNA", "Major pathway of rRNA processing in the nucleolus and cytosol"], "54514": ["PIWI-interacting RNA (piRNA) biogenesis"], "54516": ["Mitochondrial translation termination"], "54517": ["tRNA modification in the nucleus and cytosol"], "54518": ["Integrin alphaIIb beta3 signaling", "GRB2:SOS provides linkage to MAPK signaling for Integrins ", "p130Cas linkage to MAPK signaling for integrins", "MAP2K and MAPK activation", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF"], "5452": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes"], "54534": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "54536": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Insulin processing", "VxPx cargo-targeting to cilium"], "54539": ["Respiratory electron transport", "Complex I biogenesis"], "54541": ["TP53 Regulates Metabolic Genes"], "54543": ["Mitochondrial protein import", "Pink/Parkin Mediated Mitophagy"], "54545": ["Synthesis of PIPs at the early endosome membrane"], "54549": ["SDK interactions"], "54555": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "54556": ["HATs acetylate histones"], "54567": ["Activated NOTCH1 Transmits Signal to the Nucleus", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant", "Constitutive Signaling by NOTCH1 HD Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "NOTCH2 Activation and Transmission of Signal to the Nucleus", "NOTCH2 Activation and Transmission of Signal to the Nucleus", "NOTCH3 Activation and Transmission of Signal to the Nucleus", "NOTCH3 Activation and Transmission of Signal to the Nucleus", "NOTCH4 Activation and Transmission of Signal to the Nucleus"], "5457": ["Regulation of TP53 Activity through Association with Co-factors"], "54575": ["Glucuronidation"], "54576": ["Glucuronidation"], "54577": ["Glucuronidation"], "54578": ["Glucuronidation"], "54579": ["Glucuronidation"], "5458": ["Regulation of TP53 Activity through Association with Co-factors"], "54583": ["Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"], "54585": ["BBSome-mediated cargo-targeting to cilium"], "54587": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "5460": ["POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation", "POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation", "Transcriptional regulation of pluripotent stem cells"], "54600": ["Glucuronidation", "PPARA activates gene expression"], "54617": ["UCH proteinases", "DNA Damage Recognition in GG-NER"], "54620": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "54623": ["Formation of RNA Pol II elongation complex ", "RNA Polymerase II Pre-transcription Events", "RNA Polymerase II Transcription Elongation", "E3 ubiquitin ligases ubiquitinate target proteins"], "54625": ["Nicotinamide salvaging"], "5464": ["Cytosolic tRNA aminoacylation", "Pyrophosphate hydrolysis"], "5465": ["RORA activates gene expression", "BMAL1:CLOCK,NPAS2 activates circadian gene expression", "PPARA activates gene expression", "PPARA activates gene expression", "Transcriptional activation of mitochondrial biogenesis", "Activation of gene expression by SREBF (SREBP)", "Transcriptional regulation of white adipocyte differentiation", "Nuclear Receptor transcription pathway", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)", "Circadian Clock", "SUMOylation of intracellular receptors"], "54657": ["Glucuronidation", "Heme degradation", "Defective UGT1A4 causes hyperbilirubinemia"], "54658": ["Glucuronidation", "Heme degradation", "Defective UGT1A1 causes hyperbilirubinemia"], "54659": ["Glucuronidation"], "54662": ["TBC/RABGAPs"], "5467": ["Import of palmitoyl-CoA into the mitochondrial matrix", "Regulation of pyruvate dehydrogenase (PDH) complex", "Nuclear Receptor transcription pathway", "Signaling by Retinoic Acid"], "54675": ["Acyl chain remodelling of PG", "Synthesis of CL"], "54676": ["Platelet degranulation "], "54677": ["Beta-oxidation of pristanoyl-CoA", "Peroxisomal protein import", "Peroxisomal protein import"], "5468": ["PPARA activates gene expression", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation", "Nuclear Receptor transcription pathway", "SUMOylation of intracellular receptors", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription", "MECP2 regulates transcription factors"], "5469": ["RORA activates gene expression", "BMAL1:CLOCK,NPAS2 activates circadian gene expression", "PPARA activates gene expression", "PPARA activates gene expression", "Generic Transcription Pathway", "Transcriptional activation of mitochondrial biogenesis", "Activation of gene expression by SREBF (SREBP)", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation", "Nuclear Receptor transcription pathway", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)", "Circadian Clock", "Estrogen-dependent gene expression"], "547": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "54700": ["RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape"], "54704": ["Regulation of pyruvate dehydrogenase (PDH) complex"], "5471": ["Purine ribonucleoside monophosphate biosynthesis"], "54715": ["MECP2 regulates transcription factors"], "54716": ["Amino acid transport across the plasma membrane", "Na+/Cl- dependent neurotransmitter transporters", "Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)", "Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)"], "5473": ["Platelet degranulation ", "Chemokine receptors bind chemokines", "G alpha (i) signalling events", "Neutrophil degranulation"], "54732": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "54734": ["Intra-Golgi traffic", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "54739": ["Interferon alpha/beta signaling"], "54742": ["Post-translational modification: synthesis of GPI-anchored proteins"], "5475": ["Inactivation, recovery and regulation of the phototransduction cascade"], "54751": ["Cell-extracellular matrix interactions"], "54756": ["MAP2K and MAPK activation"], "54757": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "5476": ["Glycosphingolipid metabolism", "MHC class II antigen presentation", "Sialic acid metabolism", "Neutrophil degranulation"], "54763": ["RHO GTPases Activate Rhotekin and Rhophilins"], "54764": ["Ovarian tumor domain proteases"], "54778": ["Downregulation of SMAD2/3:SMAD4 transcriptional activity", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Formation of Incision Complex in GG-NER", "Antigen processing: Ubiquitination & Proteasome degradation"], "5478": ["Platelet degranulation ", "Uncoating of the HIV Virion", "Budding and maturation of HIV virion", "Integration of provirus", "Early Phase of HIV Life Cycle", "Minus-strand DNA synthesis", "Plus-strand DNA synthesis", "Binding and entry of HIV virion", "Assembly Of The HIV Virion", "APOBEC3G mediated resistance to HIV-1 infection", "Calcineurin activates NFAT", "Basigin interactions", "Neutrophil degranulation", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "54780": ["SUMOylation of DNA damage response and repair proteins"], "5479": ["Collagen biosynthesis and modifying enzymes"], "54790": ["TET1,2,3 and TDG demethylate DNA"], "54795": ["TRP channels"], "54797": ["PPARA activates gene expression", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "54801": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "54802": ["tRNA modification in the nucleus and cytosol", "tRNA modification in the mitochondrion"], "54806": ["Anchoring of the basal body to the plasma membrane"], "54807": ["Generic Transcription Pathway"], "5481": ["ESR-mediated signaling"], "54811": ["Generic Transcription Pathway"], "54815": ["HDACs deacetylate histones", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "Regulation of TP53 Activity through Acetylation", "RNA Polymerase I Transcription Initiation", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription"], "54820": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "RHO GTPases Activate Formins", "Mitotic Prometaphase", "AURKA Activation by TPX2"], "54821": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "54822": ["TRP channels"], "54829": ["ECM proteoglycans"], "54831": ["Stimuli-sensing channels"], "54839": ["Carboxyterminal post-translational modifications of tubulin"], "54845": ["Signaling by BRAF and RAF fusions", "FGFR2 alternative splicing"], "54848": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "54850": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "54859": ["HATs acetylate histones"], "548593": ["Resolution of D-loop Structures through Holliday Junction Intermediates", "Fanconi Anemia Pathway"], "548596": ["Creatine metabolism"], "54863": ["Platelet degranulation "], "54872": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "54874": ["Clathrin-mediated endocytosis"], "54876": ["Neddylation"], "54881": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "54883": ["mRNA Splicing - Major Pathway"], "54884": ["Retinoid metabolism and transport"], "54885": ["Golgi Associated Vesicle Biogenesis"], "54886": ["Lysosphingolipid and LPA receptors"], "54888": ["tRNA modification in the nucleus and cytosol", "tRNA modification in the nucleus and cytosol"], "54890": ["Reversal of alkylation damage by DNA dioxygenases"], "54891": ["UCH proteinases", "DNA Damage Recognition in GG-NER"], "54892": ["Condensation of Prophase Chromosomes"], "54893": ["Synthesis of PIPs at the early endosome membrane"], "54894": ["Regulation of FZD by ubiquitination", "RNF mutants show enhanced WNT signaling and proliferation"], "54896": ["Miscellaneous transport and binding events"], "54898": ["Linoleic acid (LA) metabolism", "alpha-linolenic acid (ALA) metabolism", "Synthesis of very long-chain fatty acyl-CoAs"], "549": ["Branched-chain amino acid catabolism"], "54901": ["tRNA modification in the nucleus and cytosol"], "54903": ["Hedgehog 'off' state", "Anchoring of the basal body to the plasma membrane"], "54904": ["PKMTs methylate histone lysines"], "54905": ["Miscellaneous substrates", "Xenobiotics"], "54908": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "54913": ["tRNA processing in the nucleus", "Major pathway of rRNA processing in the nucleolus and cytosol"], "54918": ["Neutrophil degranulation"], "54920": ["tRNA modification in the nucleus and cytosol"], "54925": ["Generic Transcription Pathway"], "54926": ["Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Antigen processing: Ubiquitination & Proteasome degradation"], "54927": ["Mitochondrial protein import", "Cristae formation"], "54928": ["Cytosolic sulfonation of small molecules"], "5493": ["Formation of the cornified envelope", "Butyrophilin (BTN) family interactions"], "54930": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "54931": ["tRNA processing in the mitochondrion", "tRNA modification in the mitochondrion", "rRNA processing in the mitochondrion"], "54934": ["HATs acetylate histones"], "54936": ["POLB-Dependent Long Patch Base Excision Repair"], "54938": ["Mitochondrial tRNA aminoacylation"], "54939": ["Neddylation"], "5494": ["Downregulation of SMAD2/3:SMAD4 transcriptional activity", "Energy dependent regulation of mTOR by LKB1-AMPK"], "54941": ["Negative regulators of DDX58/IFIH1 signaling"], "54947": ["Acyl chain remodelling of PC"], "54948": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "5495": ["ISG15 antiviral mechanism"], "54951": ["Neddylation"], "54956": ["Nicotinamide salvaging"], "54959": ["Amyloid fiber formation"], "54960": ["snRNP Assembly"], "54962": ["Processing of DNA double-strand break ends"], "54963": ["Pyrimidine salvage"], "54965": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "54971": ["Regulation of TP53 Activity through Association with Co-factors"], "54972": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "54973": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes"], "54974": ["tRNA modification in the nucleus and cytosol"], "54979": ["Acyl chain remodelling of PE"], "5498": ["Heme biosynthesis"], "54981": ["Nicotinate metabolism"], "54988": ["Conjugation of salicylate with glycine"], "54989": ["Generic Transcription Pathway"], "5499": ["Triglyceride catabolism", "DARPP-32 events", "Downregulation of TGF-beta receptor signaling", "Circadian Clock"], "54996": ["Phase I - Functionalization of compounds"], "54998": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "55": ["Neutrophil degranulation"], "5500": ["Triglyceride catabolism", "Downregulation of TGF-beta receptor signaling", "Regulation of PLK1 Activity at G2/M Transition", "Circadian Clock", "RHO GTPases activate PKNs", "RHO GTPases activate PKNs", "RHO GTPases activate CIT", "RHO GTPases Activate ROCKs", "RHO GTPases activate PAKs", "RHO GTPases activate PAKs"], "55004": ["Macroautophagy", "mTOR signalling", "mTORC1-mediated signalling", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Neutrophil degranulation", "Regulation of PTEN gene transcription"], "55006": ["tRNA modification in the mitochondrion"], "55008": ["Antigen processing: Ubiquitination & Proteasome degradation"], "5501": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Triglyceride catabolism", "Downregulation of TGF-beta receptor signaling", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Circadian Clock", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "55013": ["Mitochondrial calcium ion transport", "Processing of SMDT1"], "55014": ["COPII-mediated vesicle transport"], "55031": ["Ub-specific processing proteases"], "55033": ["XBP1(S) activates chaperone genes"], "55034": ["Molybdenum cofactor biosynthesis"], "55037": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "55039": ["Synthesis of wybutosine at G37 of tRNA(Phe)"], "55048": ["Budding and maturation of HIV virion", "Membrane binding and targetting of GAG proteins", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "55052": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "55054": ["Macroautophagy", "Macroautophagy"], "55055": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "55062": ["Macroautophagy", "XBP1(S) activates chaperone genes"], "55065": ["Vitamin B2 (riboflavin) metabolism"], "55066": ["Regulation of pyruvate dehydrogenase (PDH) complex"], "5507": ["Glycogen synthesis", "Myoclonic epilepsy of Lafora"], "55070": ["Antigen processing: Ubiquitination & Proteasome degradation"], "55072": ["Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway"], "55075": ["Regulation of the apoptosome activity"], "55081": ["Hedgehog 'off' state", "Intraflagellar transport", "Intraflagellar transport"], "55083": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "55089": ["Amino acid transport across the plasma membrane"], "55090": ["PPARA activates gene expression", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "551": ["BMAL1:CLOCK,NPAS2 activates circadian gene expression", "Vasopressin-like receptors", "G alpha (q) signalling events", "G alpha (s) signalling events", "Vasopressin regulates renal water homeostasis via Aquaporins", "Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI)", "Transport of organic anions", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI)"], "55107": ["Stimuli-sensing channels"], "55109": ["Signaling by BRAF and RAF fusions"], "55110": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "55112": ["Intraflagellar transport"], "55114": ["Rho GTPase cycle"], "55117": ["Amino acid transport across the plasma membrane", "Na+/Cl- dependent neurotransmitter transporters"], "55120": ["Fanconi Anemia Pathway"], "55124": ["PIWI-interacting RNA (piRNA) biogenesis"], "55125": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "55127": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "55128": ["Interferon gamma signaling"], "55129": ["Stimuli-sensing channels"], "55131": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "55135": ["Telomere Extension By Telomerase", "Association of TriC/CCT with target proteins during biosynthesis"], "55140": ["HATs acetylate histones"], "55142": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "55143": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA replication proteins", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "55144": ["Miscellaneous transport and binding events"], "5515": ["Inhibition of replication initiation of damaged DNA by RB1/E2F1", "Spry regulation of FGF signaling", "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Integration of energy metabolism", "PP2A-mediated dephosphorylation of key metabolic factors", "DARPP-32 events", "Degradation of beta-catenin by the destruction complex", "Beta-catenin phosphorylation cascade", "ERK/MAPK targets", "ERKs are inactivated", "MASTL Facilitates Mitotic Progression", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Initiation of Nuclear Envelope Reformation", "CTLA4 inhibitory signaling", "Platelet sensitization by LDL", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Misspliced GSK3beta mutants stabilize beta-catenin", "S33 mutants of beta-catenin aren't phosphorylated", "S37 mutants of beta-catenin aren't phosphorylated", "S45 mutants of beta-catenin aren't phosphorylated", "T41 mutants of beta-catenin aren't phosphorylated", "APC truncation mutants have impaired AXIN binding", "AXIN missense mutants destabilize the destruction complex", "Truncations of AMER1 destabilize the destruction complex", "RHO GTPases Activate Formins", "RAF activation", "Negative regulation of MAPK pathway", "Regulation of TP53 Degradation", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Mitotic Prometaphase", "Cyclin D associated events in G1", "Cyclin A/B1/B2 associated events during G2/M transition", "Glycolysis", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "55157": ["Mitochondrial tRNA aminoacylation"], "5516": ["Inhibition of replication initiation of damaged DNA by RB1/E2F1", "Spry regulation of FGF signaling", "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Integration of energy metabolism", "PP2A-mediated dephosphorylation of key metabolic factors", "DARPP-32 events", "Degradation of beta-catenin by the destruction complex", "Beta-catenin phosphorylation cascade", "ERK/MAPK targets", "ERKs are inactivated", "MASTL Facilitates Mitotic Progression", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "CTLA4 inhibitory signaling", "Platelet sensitization by LDL", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Misspliced GSK3beta mutants stabilize beta-catenin", "S33 mutants of beta-catenin aren't phosphorylated", "S37 mutants of beta-catenin aren't phosphorylated", "S45 mutants of beta-catenin aren't phosphorylated", "T41 mutants of beta-catenin aren't phosphorylated", "APC truncation mutants have impaired AXIN binding", "AXIN missense mutants destabilize the destruction complex", "Truncations of AMER1 destabilize the destruction complex", "RHO GTPases Activate Formins", "RAF activation", "Negative regulation of MAPK pathway", "Regulation of TP53 Degradation", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Mitotic Prometaphase", "Cyclin D associated events in G1", "Cyclin A/B1/B2 associated events during G2/M transition", "Glycolysis"], "55160": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "55163": ["Vitamins B6 activation to pyridoxal phosphate"], "55166": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Deposition of new CENPA-containing nucleosomes at the centromere", "Mitotic Prometaphase"], "55167": ["HATs acetylate histones"], "55168": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "55170": ["RMTs methylate histone arginines", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"], "55173": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "55174": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes"], "55175": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "55176": ["ER-Phagosome pathway", "SRP-dependent cotranslational protein targeting to membrane", "XBP1(S) activates chaperone genes"], "55178": ["rRNA modification in the mitochondrion"], "5518": ["Inhibition of replication initiation of damaged DNA by RB1/E2F1", "Spry regulation of FGF signaling", "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Integration of energy metabolism", "PP2A-mediated dephosphorylation of key metabolic factors", "DARPP-32 events", "Degradation of beta-catenin by the destruction complex", "Beta-catenin phosphorylation cascade", "ERK/MAPK targets", "ERKs are inactivated", "MASTL Facilitates Mitotic Progression", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Regulation of PLK1 Activity at G2/M Transition", "Initiation of Nuclear Envelope Reformation", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "CTLA4 inhibitory signaling", "Platelet sensitization by LDL", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Misspliced GSK3beta mutants stabilize beta-catenin", "S33 mutants of beta-catenin aren't phosphorylated", "S37 mutants of beta-catenin aren't phosphorylated", "S45 mutants of beta-catenin aren't phosphorylated", "T41 mutants of beta-catenin aren't phosphorylated", "APC truncation mutants have impaired AXIN binding", "AXIN missense mutants destabilize the destruction complex", "Truncations of AMER1 destabilize the destruction complex", "Anchoring of the basal body to the plasma membrane", "RHO GTPases Activate Formins", "RAF activation", "Negative regulation of MAPK pathway", "Regulation of TP53 Degradation", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Mitotic Prometaphase", "Cyclin D associated events in G1", "Cyclin A/B1/B2 associated events during G2/M transition", "Glycolysis", "AURKA Activation by TPX2", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "55181": ["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "55182": ["Antigen processing: Ubiquitination & Proteasome degradation"], "55183": ["Nonhomologous End-Joining (NHEJ)"], "5519": ["Inhibition of replication initiation of damaged DNA by RB1/E2F1", "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Integration of energy metabolism", "PP2A-mediated dephosphorylation of key metabolic factors", "DARPP-32 events", "Degradation of beta-catenin by the destruction complex", "Beta-catenin phosphorylation cascade", "ERK/MAPK targets", "ERKs are inactivated", "MASTL Facilitates Mitotic Progression", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "CTLA4 inhibitory signaling", "Platelet sensitization by LDL", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Misspliced GSK3beta mutants stabilize beta-catenin", "S33 mutants of beta-catenin aren't phosphorylated", "S37 mutants of beta-catenin aren't phosphorylated", "S45 mutants of beta-catenin aren't phosphorylated", "T41 mutants of beta-catenin aren't phosphorylated", "APC truncation mutants have impaired AXIN binding", "AXIN missense mutants destabilize the destruction complex", "Truncations of AMER1 destabilize the destruction complex", "RHO GTPases Activate Formins", "RAF activation", "Negative regulation of MAPK pathway", "Regulation of TP53 Degradation", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Mitotic Prometaphase", "Cyclin D associated events in G1", "Cyclin A/B1/B2 associated events during G2/M transition", "Glycolysis"], "55190": ["Synthesis of pyrophosphates in the cytosol"], "55191": ["Nicotinate metabolism"], "55193": ["RMTs methylate histone arginines", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "55197": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes"], "552": ["Vasopressin-like receptors", "G alpha (q) signalling events", "Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI)"], "5520": ["Initiation of Nuclear Envelope Reformation", "Cyclin D associated events in G1", "Cyclin A/B1/B2 associated events during G2/M transition", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "55203": ["LGI-ADAM interactions"], "55208": ["Neddylation"], "55211": ["POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation"], "55212": ["BBSome-mediated cargo-targeting to cilium"], "55214": ["Collagen biosynthesis and modifying enzymes"], "55215": ["Fanconi Anemia Pathway", "TP53 Regulates Transcription of DNA Repair Genes"], "55217": ["Carnitine synthesis"], "55223": ["Interferon gamma signaling"], "55224": ["Synthesis of PE"], "55226": ["rRNA modification in the nucleus and cytosol"], "55229": ["Coenzyme A biosynthesis"], "55233": ["Signaling by Hippo"], "55236": ["Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Antigen processing: Ubiquitination & Proteasome degradation"], "55240": ["TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "Transferrin endocytosis and recycling"], "55243": ["Nephrin family interactions", "Nephrin family interactions"], "55244": ["Transport of bile salts and organic acids, metal ions and amine compounds"], "5525": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Degradation of beta-catenin by the destruction complex", "Beta-catenin phosphorylation cascade", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "CTLA4 inhibitory signaling", "Platelet sensitization by LDL", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Misspliced GSK3beta mutants stabilize beta-catenin", "S33 mutants of beta-catenin aren't phosphorylated", "S37 mutants of beta-catenin aren't phosphorylated", "S45 mutants of beta-catenin aren't phosphorylated", "T41 mutants of beta-catenin aren't phosphorylated", "APC truncation mutants have impaired AXIN binding", "AXIN missense mutants destabilize the destruction complex", "Truncations of AMER1 destabilize the destruction complex", "RHO GTPases Activate Formins", "RAF activation", "Negative regulation of MAPK pathway", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Mitotic Prometaphase"], "55250": ["HATs acetylate histones"], "55252": ["UCH proteinases"], "55253": ["Synthesis of wybutosine at G37 of tRNA(Phe)"], "55256": ["Methionine salvage pathway"], "55257": ["HATs acetylate histones"], "5526": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Degradation of beta-catenin by the destruction complex", "Beta-catenin phosphorylation cascade", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "XBP1(S) activates chaperone genes", "CTLA4 inhibitory signaling", "Platelet sensitization by LDL", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Misspliced GSK3beta mutants stabilize beta-catenin", "S33 mutants of beta-catenin aren't phosphorylated", "S37 mutants of beta-catenin aren't phosphorylated", "S45 mutants of beta-catenin aren't phosphorylated", "T41 mutants of beta-catenin aren't phosphorylated", "APC truncation mutants have impaired AXIN binding", "AXIN missense mutants destabilize the destruction complex", "Truncations of AMER1 destabilize the destruction complex", "RHO GTPases Activate Formins", "RAF activation", "Negative regulation of MAPK pathway", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Mitotic Prometaphase"], "5527": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Degradation of beta-catenin by the destruction complex", "Beta-catenin phosphorylation cascade", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "CTLA4 inhibitory signaling", "Platelet sensitization by LDL", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Misspliced GSK3beta mutants stabilize beta-catenin", "S33 mutants of beta-catenin aren't phosphorylated", "S37 mutants of beta-catenin aren't phosphorylated", "S45 mutants of beta-catenin aren't phosphorylated", "T41 mutants of beta-catenin aren't phosphorylated", "APC truncation mutants have impaired AXIN binding", "AXIN missense mutants destabilize the destruction complex", "Truncations of AMER1 destabilize the destruction complex", "RHO GTPases Activate Formins", "RAF activation", "Negative regulation of MAPK pathway", "Regulation of TP53 Degradation", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Mitotic Prometaphase"], "55270": ["Phosphate bond hydrolysis by NUDT proteins"], "55272": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "55275": ["Retrograde transport at the Trans-Golgi-Network"], "55276": ["Glycogen synthesis", "Neutrophil degranulation", "Glycogen breakdown (glycogenolysis)", "Galactose catabolism", "Pentose phosphate pathway"], "5528": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Integration of energy metabolism", "PP2A-mediated dephosphorylation of key metabolic factors", "DARPP-32 events", "Degradation of beta-catenin by the destruction complex", "Beta-catenin phosphorylation cascade", "ERK/MAPK targets", "ERKs are inactivated", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "CTLA4 inhibitory signaling", "Platelet sensitization by LDL", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Misspliced GSK3beta mutants stabilize beta-catenin", "S33 mutants of beta-catenin aren't phosphorylated", "S37 mutants of beta-catenin aren't phosphorylated", "S45 mutants of beta-catenin aren't phosphorylated", "T41 mutants of beta-catenin aren't phosphorylated", "APC truncation mutants have impaired AXIN binding", "AXIN missense mutants destabilize the destruction complex", "Truncations of AMER1 destabilize the destruction complex", "RHO GTPases Activate Formins", "RAF activation", "Negative regulation of MAPK pathway", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Mitotic Prometaphase", "Glycolysis"], "55283": ["TRP channels"], "55284": ["Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Antigen processing: Ubiquitination & Proteasome degradation"], "55288": ["Rho GTPase cycle", "Ub-specific processing proteases"], "55289": ["Beta-oxidation of pristanoyl-CoA"], "5529": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Degradation of beta-catenin by the destruction complex", "Beta-catenin phosphorylation cascade", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "CTLA4 inhibitory signaling", "Platelet sensitization by LDL", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Misspliced GSK3beta mutants stabilize beta-catenin", "S33 mutants of beta-catenin aren't phosphorylated", "S37 mutants of beta-catenin aren't phosphorylated", "S45 mutants of beta-catenin aren't phosphorylated", "T41 mutants of beta-catenin aren't phosphorylated", "APC truncation mutants have impaired AXIN binding", "AXIN missense mutants destabilize the destruction complex", "Truncations of AMER1 destabilize the destruction complex", "RHO GTPases Activate Formins", "RAF activation", "Negative regulation of MAPK pathway", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Mitotic Prometaphase"], "55290": ["RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "552900": ["Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "55291": ["COPII-mediated vesicle transport"], "55294": ["NOTCH1 Intracellular Domain Regulates Transcription", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "Association of TriC/CCT with target proteins during biosynthesis", "Regulation of RUNX2 expression and activity", "Neddylation", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "553": ["Vasopressin-like receptors", "G alpha (q) signalling events", "Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI)"], "5530": ["DARPP-32 events", "Calcineurin activates NFAT", "Calcineurin activates NFAT", "FCERI mediated Ca+2 mobilization", "Ca2+ pathway", "CLEC7A (Dectin-1) induces NFAT activation"], "55300": ["Synthesis of PIPs at the ER membrane", "Synthesis of PIPs at the plasma membrane", "Synthesis of PIPs at the Golgi membrane", "Synthesis of PIPs at the early endosome membrane"], "55301": ["Fatty acyl-CoA biosynthesis"], "55304": ["Sphingolipid de novo biosynthesis"], "5531": ["Processing of DNA double-strand break ends"], "55312": ["Vitamin B2 (riboflavin) metabolism"], "55313": ["Neutrophil degranulation"], "55315": ["Defective SLC29A3 causes histiocytosis-lymphadenopathy plus syndrome (HLAS)", "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"], "5532": ["DARPP-32 events", "Calcineurin activates NFAT", "Calcineurin activates NFAT", "FCERI mediated Ca+2 mobilization", "Ca2+ pathway", "CLEC7A (Dectin-1) induces NFAT activation", "ROBO receptors bind AKAP5"], "55320": ["Deposition of new CENPA-containing nucleosomes at the centromere"], "55326": ["Synthesis of PA"], "55327": ["Dopamine Neurotransmitter Release Cycle", "Neurexins and neuroligins"], "55328": ["Nicotinamide salvaging"], "5533": ["Activation of BAD and translocation to mitochondria ", "DARPP-32 events"], "55330": ["Golgi Associated Vesicle Biogenesis"], "55331": ["Sphingolipid de novo biosynthesis"], "55336": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "55339": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA Derived from an Intronless Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "5534": ["Activation of BAD and translocation to mitochondria ", "DARPP-32 events", "Calcineurin activates NFAT", "Calcineurin activates NFAT", "FCERI mediated Ca+2 mobilization", "Ca2+ pathway", "CLEC7A (Dectin-1) induces NFAT activation"], "55343": ["Defective SLC35C1 causes congenital disorder of glycosylation 2C (CDG2C)", "GDP-fucose biosynthesis", "Transport of nucleotide sugars"], "55347": ["Glucuronidation"], "55349": ["Choline catabolism"], "55350": ["Post-translational modification: synthesis of GPI-anchored proteins"], "55352": ["RMTs methylate histone arginines"], "55355": ["Deposition of new CENPA-containing nucleosomes at the centromere"], "55356": ["Organic cation transport"], "55357": ["TBC/RABGAPs"], "5536": ["Negative regulation of MAPK pathway", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "ESR-mediated signaling"], "55361": ["Synthesis of PIPs at the plasma membrane", "Synthesis of PIPs at the Golgi membrane", "Synthesis of PIPs at the early endosome membrane"], "55366": ["Regulation of FZD by ubiquitination"], "55367": ["TP53 Regulates Transcription of Caspase Activators and Caspases"], "5537": ["COPII-mediated vesicle transport"], "5538": ["Fatty acyl-CoA biosynthesis"], "55388": ["Activation of ATR in response to replication stress", "Activation of the pre-replicative complex"], "5539": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "554": ["Vasopressin-like receptors", "G alpha (s) signalling events", "Vasopressin regulates renal water homeostasis via Aquaporins", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI)"], "5540": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "55422": ["Generic Transcription Pathway"], "55423": ["Cell surface interactions at the vascular wall", "Signal regulatory protein family interactions"], "554313": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "SUMOylation of chromatin organization proteins", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "55432": ["Ovarian tumor domain proteases"], "55437": ["Energy dependent regulation of mTOR by LKB1-AMPK"], "55454": ["Chondroitin sulfate biosynthesis"], "5546": ["mRNA Splicing - Major Pathway"], "55466": ["HSP90 chaperone cycle for steroid hormone receptors (SHR)"], "5547": ["Intrinsic Pathway of Fibrin Clot Formation", "Neutrophil degranulation"], "55471": ["Complex I biogenesis"], "55486": ["Processing of SMDT1"], "5549": ["Keratan sulfate biosynthesis", "Keratan sulfate degradation", "Defective CHST6 causes MCDC1", "Defective ST3GAL3 causes MCT12 and EIEE15", "Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)"], "55500": ["Synthesis of PE"], "55501": ["Chondroitin sulfate biosynthesis"], "55503": ["TRP channels"], "55505": ["rRNA modification in the nucleus and cytosol"], "55512": ["Glycosphingolipid metabolism", "TNFR1-mediated ceramide production"], "55515": ["Stimuli-sensing channels"], "5552": ["Platelet degranulation "], "55521": ["Antigen processing: Ubiquitination & Proteasome degradation"], "55526": ["Glyoxylate metabolism and glycine degradation"], "55527": ["Neddylation"], "5553": ["Neutrophil degranulation"], "55532": ["Metal ion SLC transporters"], "55534": ["Pre-NOTCH Transcription and Translation", "Pre-NOTCH Transcription and Translation", "Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "NOTCH1 Intracellular Domain Regulates Transcription", "NOTCH1 Intracellular Domain Regulates Transcription", "NOTCH2 intracellular domain regulates transcription", "NOTCH2 intracellular domain regulates transcription", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "Notch-HLH transcription pathway", "RUNX3 regulates NOTCH signaling", "RUNX3 regulates NOTCH signaling", "NOTCH3 Intracellular Domain Regulates Transcription", "NOTCH3 Intracellular Domain Regulates Transcription", "NOTCH4 Intracellular Domain Regulates Transcription", "NOTCH4 Intracellular Domain Regulates Transcription"], "55540": ["Interleukin-17 signaling"], "55553": ["Deactivation of the beta-catenin transactivating complex"], "55558": ["Sema3A PAK dependent Axon repulsion", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "CRMPs in Sema3A signaling", "CRMPs in Sema3A signaling"], "55559": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "55568": ["O-linked glycosylation of mucins"], "5557": ["Inhibition of replication initiation of damaged DNA by RB1/E2F1", "Polymerase switching on the C-strand of the telomere", "Telomere C-strand synthesis initiation", "DNA replication initiation", "Activation of the pre-replicative complex", "Polymerase switching", "Removal of the Flap Intermediate", "Processive synthesis on the lagging strand"], "55571": ["Deadenylation of mRNA", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "55576": ["Hyaluronan uptake and degradation", "Scavenging by Class H Receptors"], "55577": ["Synthesis of UDP-N-acetyl-glucosamine"], "55578": ["HATs acetylate histones"], "5558": ["Inhibition of replication initiation of damaged DNA by RB1/E2F1", "Polymerase switching on the C-strand of the telomere", "Telomere C-strand synthesis initiation", "DNA replication initiation", "Activation of the pre-replicative complex", "Polymerase switching", "Removal of the Flap Intermediate", "Processive synthesis on the lagging strand"], "55582": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "55584": ["Highly calcium permeable postsynaptic nicotinic acetylcholine receptors"], "55585": ["Antigen processing: Ubiquitination & Proteasome degradation"], "55586": ["Synthesis of IP2, IP, and Ins in the cytosol"], "55588": ["PPARA activates gene expression", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "55593": ["Ovarian tumor domain proteases", "Negative regulators of DDX58/IFIH1 signaling"], "55599": ["mRNA Splicing - Minor Pathway"], "55600": ["Antimicrobial peptides"], "55604": ["Factors involved in megakaryocyte development and platelet production"], "55605": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "55611": ["Ub-specific processing proteases", "Ovarian tumor domain proteases"], "55613": ["Synthesis of PIPs at the plasma membrane"], "55614": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "55615": ["PIP3 activates AKT signaling", "CD28 dependent PI3K/Akt signaling", "VEGFR2 mediated vascular permeability", "Constitutive Signaling by AKT1 E17K in Cancer", "Regulation of TP53 Degradation"], "55619": ["Factors involved in megakaryocyte development and platelet production"], "5562": ["Macroautophagy", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Regulation of TP53 Activity through Phosphorylation", "Activation of AMPK downstream of NMDARs"], "55620": ["PTK6 Activates STAT3"], "55621": ["tRNA modification in the nucleus and cytosol"], "55623": ["rRNA modification in the nucleus and cytosol"], "55624": ["Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3", "O-linked glycosylation"], "55626": ["Macroautophagy"], "55627": ["Glycosphingolipid metabolism"], "55629": ["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "5563": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Macroautophagy", "AMPK inhibits chREBP transcriptional activation activity", "AMPK inhibits chREBP transcriptional activation activity", "Import of palmitoyl-CoA into the mitochondrial matrix", "Activation of PPARGC1A (PGC-1alpha) by phosphorylation", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Regulation of TP53 Activity through Phosphorylation", "Activation of AMPK downstream of NMDARs"], "55630": ["Zinc influx into cells by the SLC39 gene family", "Defective SLC39A4 causes acrodermatitis enteropathica, zinc-deficiency type (AEZ)"], "55634": ["Generic Transcription Pathway"], "5564": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Macroautophagy", "Activation of PPARGC1A (PGC-1alpha) by phosphorylation", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Regulation of TP53 Activity through Phosphorylation", "Activation of AMPK downstream of NMDARs"], "55644": ["tRNA modification in the nucleus and cytosol"], "55647": ["RAB geranylgeranylation"], "5565": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Macroautophagy", "AMPK inhibits chREBP transcriptional activation activity", "AMPK inhibits chREBP transcriptional activation activity", "Import of palmitoyl-CoA into the mitochondrial matrix", "Activation of PPARGC1A (PGC-1alpha) by phosphorylation", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Regulation of TP53 Activity through Phosphorylation", "Activation of AMPK downstream of NMDARs"], "55650": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "55651": ["Telomere Extension By Telomerase", "rRNA modification in the nucleus and cytosol"], "55656": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes"], "55657": ["Generic Transcription Pathway"], "55658": ["Antigen processing: Ubiquitination & Proteasome degradation"], "55659": ["Generic Transcription Pathway"], "5566": ["PKA-mediated phosphorylation of CREB", "PKA-mediated phosphorylation of key metabolic factors", "Triglyceride catabolism", "PKA activation", "PKA activation in glucagon signalling", "DARPP-32 events", "Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Rap1 signalling", "Regulation of insulin secretion", "Vasopressin regulates renal water homeostasis via Aquaporins", "VEGFA-VEGFR2 Pathway", "CREB1 phosphorylation through the activation of Adenylate Cyclase", "CREB1 phosphorylation through the activation of Adenylate Cyclase", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "Ion homeostasis", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'off' state", "Anchoring of the basal body to the plasma membrane", "CD209 (DC-SIGN) signaling", "MAPK6/MAPK4 signaling", "Glycolysis", "RET signaling", "AURKA Activation by TPX2", "HDL assembly", "ROBO receptors bind AKAP5", "Loss of phosphorylation of MECP2 at T308", "Regulation of MECP2 expression and activity", "Factors involved in megakaryocyte development and platelet production"], "55660": ["mRNA Splicing - Major Pathway"], "55662": ["Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha"], "55663": ["Generic Transcription Pathway"], "55664": ["Platelet degranulation "], "55666": ["Translesion Synthesis by POLH"], "55667": ["RAB GEFs exchange GTP for GDP on RABs"], "55669": ["Pink/Parkin Mediated Mitophagy", "Factors involved in megakaryocyte development and platelet production"], "5567": ["PKA-mediated phosphorylation of CREB", "PKA-mediated phosphorylation of key metabolic factors", "Triglyceride catabolism", "PKA activation", "PKA activation in glucagon signalling", "DARPP-32 events", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Rap1 signalling", "Regulation of insulin secretion", "Vasopressin regulates renal water homeostasis via Aquaporins", "VEGFA-VEGFR2 Pathway", "CREB1 phosphorylation through the activation of Adenylate Cyclase", "CREB1 phosphorylation through the activation of Adenylate Cyclase", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'off' state", "CD209 (DC-SIGN) signaling", "MAPK6/MAPK4 signaling", "Glycolysis", "RET signaling", "HDL assembly", "ROBO receptors bind AKAP5", "Factors involved in megakaryocyte development and platelet production"], "55670": ["Peroxisomal protein import", "Peroxisomal protein import"], "55676": ["Insulin processing", "Zinc efflux and compartmentalization by the SLC30 family"], "55677": ["Formation of RNA Pol II elongation complex ", "RNA Polymerase II Pre-transcription Events", "RNA Polymerase II Transcription Elongation"], "55679": ["Cell-extracellular matrix interactions"], "5568": ["PKA-mediated phosphorylation of CREB", "PKA-mediated phosphorylation of key metabolic factors", "Triglyceride catabolism", "PKA activation", "PKA activation in glucagon signalling", "DARPP-32 events", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Rap1 signalling", "Regulation of insulin secretion", "Vasopressin regulates renal water homeostasis via Aquaporins", "VEGFA-VEGFR2 Pathway", "CREB1 phosphorylation through the activation of Adenylate Cyclase", "CREB1 phosphorylation through the activation of Adenylate Cyclase", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'off' state", "CD209 (DC-SIGN) signaling", "MAPK6/MAPK4 signaling", "Glycolysis", "RET signaling", "HDL assembly", "ROBO receptors bind AKAP5", "Factors involved in megakaryocyte development and platelet production"], "55683": ["HATs acetylate histones"], "55687": ["tRNA modification in the mitochondrion"], "55689": ["HATs acetylate histones"], "55690": ["Nef mediated downregulation of MHC class I complex cell surface expression"], "55693": ["HDMs demethylate histones"], "55696": ["mRNA Splicing - Major Pathway"], "55697": ["Synthesis of PIPs at the Golgi membrane", "Synthesis of PIPs at the Golgi membrane", "Synthesis of PIPs at the early endosome membrane", "Synthesis of PIPs at the early endosome membrane", "Synthesis of PIPs at the late endosome membrane", "Synthesis of PIPs at the late endosome membrane"], "55699": ["Mitochondrial tRNA aminoacylation"], "55701": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "55703": ["Cytosolic sensors of pathogen-associated DNA ", "RNA Polymerase III Chain Elongation", "RNA Polymerase III Transcription Termination", "RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "55706": ["ISG15 antiviral mechanism", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "tRNA processing in the nucleus"], "55707": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "5571": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Macroautophagy", "Activation of PPARGC1A (PGC-1alpha) by phosphorylation", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Regulation of TP53 Activity through Phosphorylation", "Activation of AMPK downstream of NMDARs"], "55711": ["Wax biosynthesis"], "55713": ["Generic Transcription Pathway"], "55715": ["RET signaling"], "55718": ["Cytosolic sensors of pathogen-associated DNA ", "RNA Polymerase III Chain Elongation", "RNA Polymerase III Transcription Termination", "RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "55720": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "55722": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "55726": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes"], "55729": ["PKMTs methylate histone lysines"], "5573": ["PKA activation", "PKA activation in glucagon signalling", "DARPP-32 events", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Vasopressin regulates renal water homeostasis via Aquaporins", "CREB1 phosphorylation through the activation of Adenylate Cyclase", "Hedgehog 'off' state", "Factors involved in megakaryocyte development and platelet production"], "55733": ["Hedgehog ligand biogenesis", "HHAT G278V abrogates palmitoylation of Hh-Np"], "55735": ["Cristae formation"], "55737": ["WNT ligand biogenesis and trafficking"], "55738": ["XBP1(S) activates chaperone genes", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "Clathrin-mediated endocytosis"], "55739": ["Nicotinamide salvaging"], "55740": ["Generation of second messenger molecules", "Signaling by ROBO receptors", "Signaling by ROBO receptors"], "55741": ["ER Quality Control Compartment (ERQC)"], "55742": ["Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "Cell-extracellular matrix interactions", "Regulation of cytoskeletal remodeling and cell spreading by IPP complex components"], "55746": ["ISG15 antiviral mechanism", "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "RHO GTPases Activate Formins", "tRNA processing in the nucleus", "Mitotic Prometaphase"], "55748": ["Glutathione synthesis and recycling"], "55749": ["mRNA Splicing - Major Pathway"], "5575": ["PKA activation", "PKA activation in glucagon signalling", "DARPP-32 events", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Vasopressin regulates renal water homeostasis via Aquaporins", "CREB1 phosphorylation through the activation of Adenylate Cyclase", "Hedgehog 'off' state", "Factors involved in megakaryocyte development and platelet production"], "55750": ["Glycerophospholipid biosynthesis", "Signaling by BRAF and RAF fusions"], "55754": ["Neutrophil degranulation"], "55755": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "55756": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes"], "55757": ["ER Quality Control Compartment (ERQC)"], "55759": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "5576": ["PKA activation", "PKA activation in glucagon signalling", "DARPP-32 events", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Vasopressin regulates renal water homeostasis via Aquaporins", "CREB1 phosphorylation through the activation of Adenylate Cyclase", "Hedgehog 'off' state", "ROBO receptors bind AKAP5", "Factors involved in megakaryocyte development and platelet production"], "55762": ["Generic Transcription Pathway"], "55763": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Insulin processing", "VxPx cargo-targeting to cilium"], "55764": ["Hedgehog 'off' state", "Intraflagellar transport"], "55766": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Deposition of new CENPA-containing nucleosomes at the centromere", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination"], "55768": ["N-glycan trimming in the ER and Calnexin/Calreticulin cycle"], "5577": ["PKA activation", "PKA activation in glucagon signalling", "DARPP-32 events", "Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Vasopressin regulates renal water homeostasis via Aquaporins", "CREB1 phosphorylation through the activation of Adenylate Cyclase", "Hedgehog 'off' state", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2", "Factors involved in megakaryocyte development and platelet production"], "55770": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Insulin processing", "VxPx cargo-targeting to cilium"], "55775": ["Nonhomologous End-Joining (NHEJ)"], "55777": ["UCH proteinases"], "55778": ["Generic Transcription Pathway"], "5578": ["Calmodulin induced events", "Disinhibition of SNARE formation", "SHC1 events in ERBB2 signaling", "Signaling by SCF-KIT", "Regulation of KIT signaling", "EGFR Transactivation by Gastrin", "Inactivation, recovery and regulation of the phototransduction cascade", "Syndecan interactions", "Acetylcholine regulates insulin secretion", "Ca2+ pathway", "Trafficking of GluR2-containing AMPA receptors", "G alpha (z) signalling events", "Depolymerisation of the Nuclear Lamina", "HuR (ELAVL1) binds and stabilizes mRNA", "WNT5A-dependent internalization of FZD4", "VEGFR2 mediated cell proliferation", "RHO GTPases Activate NADPH Oxidases", "Response to elevated platelet cytosolic Ca2+", "RET signaling", "ROBO receptors bind AKAP5", "ROBO receptors bind AKAP5"], "55781": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "55786": ["Generic Transcription Pathway"], "55788": ["Cobalamin (Cbl, vitamin B12) transport and metabolism", "Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF"], "55789": ["Rho GTPase cycle"], "5579": ["Disinhibition of SNARE formation", "Activation of NF-kappaB in B cells", "Trafficking of GluR2-containing AMPA receptors", "G alpha (z) signalling events", "Depolymerisation of the Nuclear Lamina", "WNT5A-dependent internalization of FZD4", "VEGFR2 mediated cell proliferation", "RHO GTPases Activate NADPH Oxidases", "Response to elevated platelet cytosolic Ca2+", "RUNX1 regulates transcription of genes involved in differentiation of myeloid cells"], "55790": ["Chondroitin sulfate biosynthesis"], "55799": ["Presynaptic depolarization and calcium channel opening", "Phase 0 - rapid depolarisation", "Phase 2 - plateau phase"], "558": ["VEGFA-VEGFR2 Pathway"], "5580": ["Apoptotic cleavage of cellular proteins", "Calmodulin induced events", "Effects of PIP2 hydrolysis", "SHC1 events in ERBB2 signaling", "DAG and IP3 signaling", "Role of phospholipids in phagocytosis", "G alpha (z) signalling events", "HuR (ELAVL1) binds and stabilizes mRNA", "VEGFR2 mediated cell proliferation", "CLEC7A (Dectin-1) signaling", "RHO GTPases Activate NADPH Oxidases", "Neutrophil degranulation", "Interferon gamma signaling"], "55800": ["Interaction between L1 and Ankyrins", "Phase 0 - rapid depolarisation"], "55801": ["Interleukin-20 family signaling"], "55802": ["mRNA decay by 5' to 3' exoribonuclease", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "55808": ["Sialic acid metabolism"], "5581": ["Effects of PIP2 hydrolysis", "SHC1 events in ERBB2 signaling", "DAG and IP3 signaling", "Role of phospholipids in phagocytosis", "G alpha (z) signalling events"], "55811": ["Hedgehog 'off' state"], "55813": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "55814": ["RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "55816": ["RET signaling"], "55818": ["HDMs demethylate histones"], "55819": ["Antigen processing: Ubiquitination & Proteasome degradation"], "5582": ["Calmodulin induced events", "Disinhibition of SNARE formation", "Trafficking of GluR2-containing AMPA receptors", "G alpha (z) signalling events", "WNT5A-dependent internalization of FZD4", "Response to elevated platelet cytosolic Ca2+"], "55824": ["GAB1 signalosome", "Phosphorylation of CD3 and TCR zeta chains"], "55825": ["Alpha-oxidation of phytanate", "Peroxisomal protein import", "Peroxisomal protein import"], "55827": ["Neddylation"], "55829": ["E3 ubiquitin ligases ubiquitinate target proteins"], "5583": ["Effects of PIP2 hydrolysis", "G alpha (z) signalling events"], "55832": ["Neutrophil degranulation", "Neddylation", "Iron uptake and transport"], "55835": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "AURKA Activation by TPX2"], "55839": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Deposition of new CENPA-containing nucleosomes at the centromere", "Mitotic Prometaphase"], "5584": ["Pre-NOTCH Transcription and Translation", "p75NTR recruits signalling complexes", "Tight junction interactions"], "55840": ["Formation of RNA Pol II elongation complex ", "RNA Polymerase II Pre-transcription Events", "RNA Polymerase II Transcription Elongation"], "55843": ["Rho GTPase cycle"], "55844": ["MASTL Facilitates Mitotic Progression"], "55845": ["Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs"], "5585": ["RHO GTPases activate PKNs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3"], "55850": ["COPI-dependent Golgi-to-ER retrograde traffic"], "55851": ["Nuclear signaling by ERBB4", "Regulated proteolysis of p75NTR", "NRIF signals cell death from the nucleus", "Activated NOTCH1 Transmits Signal to the Nucleus", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "NOTCH2 Activation and Transmission of Signal to the Nucleus", "EPH-ephrin mediated repulsion of cells", "NOTCH3 Activation and Transmission of Signal to the Nucleus", "NOTCH4 Activation and Transmission of Signal to the Nucleus", "Noncanonical activation of NOTCH3", "Amyloid fiber formation"], "55856": ["Mitochondrial Fatty Acid Beta-Oxidation"], "5586": ["RHO GTPases activate PKNs"], "55860": ["MHC class II antigen presentation", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Neutrophil degranulation", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic"], "55863": ["Complex I biogenesis"], "55867": ["Organic anion transport"], "55869": ["NOTCH1 Intracellular Domain Regulates Transcription", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "HDACs deacetylate histones"], "5587": ["Sphingolipid de novo biosynthesis"], "55870": ["PKMTs methylate histone lysines"], "55879": ["GABA A receptor activation", "GABA receptor activation"], "5588": ["Apoptotic cleavage of cellular proteins", "Effects of PIP2 hydrolysis", "Downstream TCR signaling", "Inactivation, recovery and regulation of the phototransduction cascade", "FCERI mediated NF-kB activation", "FCERI mediated NF-kB activation", "Netrin-1 signaling", "G alpha (z) signalling events", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"], "55884": ["Neddylation"], "55888": ["Generic Transcription Pathway"], "5589": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "Advanced glycosylation endproduct receptor signaling", "Post-translational protein phosphorylation", "Calnexin/calreticulin cycle"], "55894": ["Beta defensins", "Defensins"], "5590": ["GPVI-mediated activation cascade", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "VEGFR2 mediated cell proliferation", "RHO GTPases Activate NADPH Oxidases"], "55900": ["Generic Transcription Pathway"], "55901": ["Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "55902": ["Transcriptional activation of mitochondrial biogenesis", "Ethanol oxidation"], "55904": ["PKMTs methylate histone lysines", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"], "55905": ["Antigen processing: Ubiquitination & Proteasome degradation"], "55907": ["Sialic acid metabolism"], "55908": ["Assembly of active LPL and LIPC lipase complexes"], "5591": ["Cytosolic sensors of pathogen-associated DNA ", "IRF3-mediated induction of type I IFN", "Nonhomologous End-Joining (NHEJ)", "E3 ubiquitin ligases ubiquitinate target proteins"], "55911": ["VLDL clearance"], "55914": ["Signaling by ERBB2", "Downregulation of ERBB2 signaling"], "5592": ["Rap1 signalling", "Ca2+ pathway", "cGMP effects", "cGMP effects"], "55920": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "55929": ["HATs acetylate histones"], "5593": ["Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "Ca2+ pathway", "cGMP effects", "cGMP effects"], "55937": ["Retinoid metabolism and transport"], "5594": ["phospho-PLA2 pathway", "RAF-independent MAPK1/3 activation", "MAPK1 (ERK2) activation", "Spry regulation of FGF signaling", "Golgi Cisternae Pericentriolar Stack Reorganization", "Frs2-mediated activation", "ERK/MAPK targets", "ERK/MAPK targets", "ERKs are inactivated", "Regulation of actin dynamics for phagocytic cup formation", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "Oncogene Induced Senescence", "Oncogene Induced Senescence", "FCERI mediated MAPK activation", "Regulation of HSF1-mediated heat shock response", "NCAM signaling for neurite out-growth", "Recycling pathway of L1", "RSK activation", "Signal transduction by L1", "Activation of the AP-1 family of transcription factors", "Thrombin signalling through proteinase activated receptors (PARs)", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate NADPH Oxidases", "RAF/MAP kinase cascade", "MAP2K and MAPK activation", "Negative feedback regulation of MAPK pathway", "Negative regulation of MAPK pathway", "Neutrophil degranulation", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Signal attenuation", "Advanced glycosylation endproduct receptor signaling", "Gastrin-CREB signalling pathway via PKC and MAPK", "ESR-mediated signaling", "RUNX2 regulates osteoblast differentiation", "Regulation of PTEN gene transcription", "Regulation of the apoptosome activity", "Growth hormone receptor signaling"], "5595": ["MAPK3 (ERK1) activation", "RAF-independent MAPK1/3 activation", "ISG15 antiviral mechanism", "Spry regulation of FGF signaling", "Golgi Cisternae Pericentriolar Stack Reorganization", "Frs2-mediated activation", "ERK/MAPK targets", "ERK/MAPK targets", "ERKs are inactivated", "Regulation of actin dynamics for phagocytic cup formation", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "Oncogene Induced Senescence", "Oncogene Induced Senescence", "FCERI mediated MAPK activation", "Regulation of HSF1-mediated heat shock response", "NCAM signaling for neurite out-growth", "RSK activation", "Signal transduction by L1", "Activation of the AP-1 family of transcription factors", "Thrombin signalling through proteinase activated receptors (PARs)", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate NADPH Oxidases", "RAF/MAP kinase cascade", "MAP2K and MAPK activation", "Negative feedback regulation of MAPK pathway", "Negative regulation of MAPK pathway", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "RNA Polymerase I Promoter Opening", "Signal attenuation", "Advanced glycosylation endproduct receptor signaling", "Gastrin-CREB signalling pathway via PKC and MAPK", "ESR-mediated signaling", "RUNX2 regulates osteoblast differentiation", "Regulation of PTEN gene transcription", "Regulation of the apoptosome activity", "Growth hormone receptor signaling"], "55954": ["mRNA Splicing - Minor Pathway"], "55957": ["Transcription of E2F targets under negative control by DREAM complex", "Transcription of E2F targets under negative control by DREAM complex", "Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1", "G0 and Early G1", "Polo-like kinase mediated events", "Activation of E2F1 target genes at G1/S", "Cyclin E associated events during G1/S transition ", "Cyclin A:Cdk2-associated events at S phase entry"], "55958": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "5596": ["MAPK6/MAPK4 signaling"], "55967": ["Respiratory electron transport", "Complex I biogenesis"], "5597": ["MAPK6/MAPK4 signaling"], "55970": ["Activation of G protein gated Potassium channels", "Glucagon signaling in metabolic regulation", "G-protein activation", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42", "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "55974": ["Cellular hexose transport"], "5598": ["ERK/MAPK targets", "ERK/MAPK targets", "Signalling to ERK5", "Signalling to ERK5", "ERKs are inactivated", "Senescence-Associated Secretory Phenotype (SASP)", "Gastrin-CREB signalling pathway via PKC and MAPK", "RET signaling"], "5599": ["Activation of BIM and translocation to mitochondria ", "Activation of BMF and translocation to mitochondria", "NRAGE signals death through JNK", "NRAGE signals death through JNK", "NRIF signals cell death from the nucleus", "Oxidative Stress Induced Senescence", "FCERI mediated MAPK activation", "DSCAM interactions", "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "Activation of the AP-1 family of transcription factors", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Interleukin-38 signaling"], "55997": ["Signaling by NODAL", "Regulation of signaling by NODAL"], "5600": ["NOD1/2 Signaling Pathway", "p38MAPK events", "p38MAPK events", "ERK/MAPK targets", "Activation of PPARGC1A (PGC-1alpha) by phosphorylation", "Oxidative Stress Induced Senescence", "CDO in myogenesis", "CDO in myogenesis", "DSCAM interactions", "VEGFA-VEGFR2 Pathway", "activated TAK1 mediates p38 MAPK activation", "Activation of the AP-1 family of transcription factors", "KSRP (KHSRP) binds and destabilizes mRNA", "RHO GTPases Activate NADPH Oxidases", "Regulation of TP53 Activity through Phosphorylation"], "56001": ["Transport of Mature mRNA derived from an Intron-Containing Transcript"], "56005": ["XBP1(S) activates chaperone genes"], "56006": ["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "5601": ["Oxidative Stress Induced Senescence", "FCERI mediated MAPK activation", "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "Activation of the AP-1 family of transcription factors"], "5602": ["Oxidative Stress Induced Senescence", "FCERI mediated MAPK activation", "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "Activation of the AP-1 family of transcription factors"], "5603": ["NOD1/2 Signaling Pathway", "p38MAPK events", "DSCAM interactions", "VEGFA-VEGFR2 Pathway"], "56034": ["Signaling by PDGF"], "5604": ["MAPK3 (ERK1) activation", "Signal transduction by L1", "Uptake and function of anthrax toxins", "RAF activation", "MAP2K and MAPK activation", "Negative feedback regulation of MAPK pathway", "MAP3K8 (TPL2)-dependent MAPK1/3 activation", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF"], "5605": ["MAPK1 (ERK2) activation", "Signal transduction by L1", "Uptake and function of anthrax toxins", "RAF activation", "MAP2K and MAPK activation", "Negative feedback regulation of MAPK pathway", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF"], "56052": ["Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "Defective ALG1 causes ALG1-CDG (CDG-1k)"], "5606": ["Oxidative Stress Induced Senescence", "activated TAK1 mediates p38 MAPK activation", "Uptake and function of anthrax toxins"], "5607": ["Signalling to ERK5"], "5608": ["NOD1/2 Signaling Pathway", "Oxidative Stress Induced Senescence", "CDO in myogenesis", "activated TAK1 mediates p38 MAPK activation", "Uptake and function of anthrax toxins", "PI5P Regulates TP53 Acetylation", "Interleukin-1 signaling"], "5609": ["Oxidative Stress Induced Senescence", "FCERI mediated MAPK activation", "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "Uptake and function of anthrax toxins"], "5610": ["ISG15 antiviral mechanism", "Inhibition of PKR"], "5611": ["Viral mRNA Translation", "XBP1(S) activates chaperone genes", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Neutrophil degranulation", "Post-translational protein phosphorylation"], "5613": ["PKA-mediated phosphorylation of CREB", "CREB1 phosphorylation through the activation of Adenylate Cyclase"], "56158": ["Meiotic synapsis"], "56160": ["SUMOylation of DNA damage response and repair proteins"], "56165": ["PIWI-interacting RNA (piRNA) biogenesis"], "5617": ["Prolactin receptor signaling", "Prolactin receptor signaling", "Amyloid fiber formation", "Growth hormone receptor signaling"], "56172": ["Miscellaneous transport and binding events"], "5618": ["Prolactin receptor signaling", "Prolactin receptor signaling", "Growth hormone receptor signaling"], "5621": ["NCAM1 interactions"], "5623": ["NCAM1 interactions", "RAF/MAP kinase cascade", "RET signaling"], "5624": ["Intrinsic Pathway of Fibrin Clot Formation", "Common Pathway of Fibrin Clot Formation", "Gamma-carboxylation of protein precursors", "Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "Removal of aminoterminal propeptides from gamma-carboxylated proteins", "Cell surface interactions at the vascular wall", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "56242": ["Generic Transcription Pathway"], "56244": ["Butyrophilin (BTN) family interactions"], "5625": ["Proline catabolism"], "56253": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "56254": ["E3 ubiquitin ligases ubiquitinate target proteins"], "56259": ["mRNA Splicing - Major Pathway"], "56261": ["Hydrolysis of LPC", "Hydrolysis of LPE"], "56262": ["Miscellaneous transport and binding events"], "56267": ["Tryptophan catabolism"], "5627": ["Platelet degranulation ", "Common Pathway of Fibrin Clot Formation", "Gamma-carboxylation of protein precursors", "Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "Removal of aminoterminal propeptides from gamma-carboxylated proteins", "Cell surface interactions at the vascular wall", "Regulation of Complement cascade"], "56270": ["Macroautophagy"], "56288": ["TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "Tight junction interactions"], "563": ["Miscellaneous transport and binding events"], "56300": ["Interleukin-36 pathway"], "56301": ["Basigin interactions", "Amino acid transport across the plasma membrane"], "56302": ["TRP channels"], "5631": ["5-Phosphoribose 1-diphosphate biosynthesis"], "56339": ["Processing of Capped Intron-Containing Pre-mRNA"], "5634": ["5-Phosphoribose 1-diphosphate biosynthesis"], "5641": ["Trafficking and processing of endosomal TLR", "Vitamin D (calciferol) metabolism", "MHC class II antigen presentation"], "56413": ["Leukotriene receptors", "G alpha (q) signalling events"], "5644": ["Activation of Matrix Metalloproteinases", "Cobalamin (Cbl, vitamin B12) transport and metabolism"], "5645": ["Collagen degradation", "Alpha-defensins", "Activation of Matrix Metalloproteinases", "Neutrophil degranulation", "Antimicrobial peptides"], "5646": ["Alpha-defensins", "Cobalamin (Cbl, vitamin B12) transport and metabolism", "Neutrophil degranulation", "Antimicrobial peptides"], "56474": ["Interconversion of nucleotide di- and triphosphates"], "56477": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "56479": ["Voltage gated Potassium channels"], "5648": ["Lectin pathway of complement activation", "Initial triggering of complement", "Ficolins bind to repetitive carbohydrate structures on the target cell surface", "Scavenging by Class A Receptors"], "5649": ["Reelin signalling pathway"], "5650": ["Degradation of the extracellular matrix"], "5652": ["Formation of the cornified envelope"], "5654": ["Degradation of the extracellular matrix"], "56548": ["Chondroitin sulfate biosynthesis"], "5657": ["Common Pathway of Fibrin Clot Formation", "Other interleukin signaling", "Neutrophil degranulation", "Antimicrobial peptides"], "566": ["Neutrophil degranulation"], "5660": ["Platelet degranulation ", "Glycosphingolipid metabolism", "Peptide ligand-binding receptors", "G alpha (i) signalling events", "Neutrophil degranulation"], "56603": ["Vitamins", "RA biosynthesis pathway", "Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA)"], "56605": ["Insulin processing"], "56606": ["Cellular hexose transport", "Defective SLC2A9 causes hypouricemia renal 2 (RHUC2)"], "56616": ["Release of apoptotic factors from the mitochondria", "SMAC (DIABLO) binds to IAPs ", "SMAC (DIABLO) binds to IAPs ", "SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ", "SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ", "SMAC, XIAP-regulated apoptotic response", "Regulation of the apoptosome activity"], "56623": ["Synthesis of PIPs at the Golgi membrane", "ARL13B-mediated ciliary trafficking of INPP5E"], "56624": ["Glycosphingolipid metabolism"], "5663": ["Nuclear signaling by ERBB4", "Degradation of the extracellular matrix", "Regulated proteolysis of p75NTR", "NRIF signals cell death from the nucleus", "Activated NOTCH1 Transmits Signal to the Nucleus", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "NOTCH2 Activation and Transmission of Signal to the Nucleus", "EPH-ephrin mediated repulsion of cells", "Neutrophil degranulation", "NOTCH3 Activation and Transmission of Signal to the Nucleus", "NOTCH4 Activation and Transmission of Signal to the Nucleus", "Noncanonical activation of NOTCH3"], "5664": ["Nuclear signaling by ERBB4", "Regulated proteolysis of p75NTR", "NRIF signals cell death from the nucleus", "Activated NOTCH1 Transmits Signal to the Nucleus", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "NOTCH2 Activation and Transmission of Signal to the Nucleus", "EPH-ephrin mediated repulsion of cells", "NOTCH3 Activation and Transmission of Signal to the Nucleus", "NOTCH4 Activation and Transmission of Signal to the Nucleus", "Noncanonical activation of NOTCH3"], "56648": ["Hypusine synthesis from eIF5A-lysine"], "56652": ["Transcriptional activation of mitochondrial biogenesis"], "56654": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "56655": ["Recognition of DNA damage by PCNA-containing replication complex", "Telomere C-strand synthesis initiation", "PCNA-Dependent Long Patch Base Excision Repair", "Termination of translesion DNA synthesis", "HDR through Homologous Recombination (HRR)", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "DNA replication initiation", "Activation of the pre-replicative complex"], "56656": ["Olfactory Signaling Pathway"], "56658": ["Antigen processing: Ubiquitination & Proteasome degradation"], "56659": ["Tandem pore domain halothane-inhibited K+ channel (THIK)", "Phase 4 - resting membrane potential"], "56660": ["Phase 4 - resting membrane potential"], "56666": ["Electric Transmission Across Gap Junctions"], "56667": ["Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)", "Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)", "Defective GALNT12 causes colorectal cancer 1 (CRCS1)", "Dectin-2 family", "O-linked glycosylation of mucins", "Termination of O-glycan biosynthesis"], "56670": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (i) signalling events"], "5669": ["Cell surface interactions at the vascular wall"], "567": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Nef mediated downregulation of MHC class I complex cell surface expression", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "DAP12 interactions", "DAP12 signaling", "DAP12 signaling", "Neutrophil degranulation", "Interferon gamma signaling", "Amyloid fiber formation", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "5670": ["Cell surface interactions at the vascular wall"], "5671": ["Cell surface interactions at the vascular wall"], "5672": ["Cell surface interactions at the vascular wall"], "56729": ["Neutrophil degranulation", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes"], "5673": ["Cell surface interactions at the vascular wall"], "5675": ["Cell surface interactions at the vascular wall"], "5676": ["Cell surface interactions at the vascular wall"], "5678": ["Cell surface interactions at the vascular wall"], "5680": ["Cell surface interactions at the vascular wall"], "5682": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "56829": ["Signaling by BRAF and RAF fusions"], "5683": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "Neutrophil degranulation", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "5684": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "56848": ["Sphingolipid de novo biosynthesis"], "5685": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "56852": ["Recognition of DNA damage by PCNA-containing replication complex", "E3 ubiquitin ligases ubiquitinate target proteins"], "5686": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "Neutrophil degranulation", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "5687": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "5688": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "56886": ["ER Quality Control Compartment (ERQC)"], "56888": ["Neutrophil degranulation"], "5689": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "Neutrophil degranulation", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "56894": ["Synthesis of PA", "COPI-independent Golgi-to-ER retrograde traffic"], "56895": ["Synthesis of PA"], "56896": ["CRMPs in Sema3A signaling"], "56898": ["Synthesis of Ketone Bodies"], "5690": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "56902": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "5691": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "56910": ["Synthesis of PC", "Synthesis of PC"], "56912": ["Intraflagellar transport", "Intraflagellar transport"], "56913": ["O-linked glycosylation of mucins"], "56915": ["ATF4 activates genes", "mRNA decay by 3' to 5' exoribonuclease", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "KSRP (KHSRP) binds and destabilizes mRNA", "Major pathway of rRNA processing in the nucleolus and cytosol"], "5692": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "56922": ["Biotin transport and metabolism", "Defective HLCS causes multiple carboxylase deficiency", "Branched-chain amino acid catabolism"], "56923": ["Peptide ligand-binding receptors", "G alpha (q) signalling events", "G alpha (i) signalling events"], "56924": ["Activation of RAC1"], "56928": ["Regulation of TNFR1 signaling"], "56929": ["Neddylation"], "5693": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "56937": ["Downregulation of TGF-beta receptor signaling"], "56938": ["BMAL1:CLOCK,NPAS2 activates circadian gene expression"], "5694": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "56942": ["Mitochondrial protein import"], "56943": ["HATs acetylate histones"], "56945": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "56949": ["Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "mRNA Splicing - Major Pathway"], "5695": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "Neutrophil degranulation", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "56950": ["PKMTs methylate histone lysines", "Regulation of TP53 Activity through Methylation"], "56953": ["Pyrimidine catabolism"], "56954": ["Neutrophil degranulation"], "56955": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "56956": ["Regulation of expression of SLITs and ROBOs"], "56957": ["TNFR1-induced proapoptotic signaling", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "Ovarian tumor domain proteases"], "5696": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Interferon alpha/beta signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "56963": ["Netrin-1 signaling"], "56965": ["Nicotinamide salvaging"], "5697": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "56970": ["HATs acetylate histones"], "56975": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "56979": ["PKMTs methylate histone lysines", "Meiotic recombination", "Meiotic recombination"], "5698": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "56983": ["Pre-NOTCH Processing in the Endoplasmic Reticulum"], "56985": ["Phosphate bond hydrolysis by NUDT proteins"], "5699": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "56992": ["MHC class II antigen presentation", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins", "Kinesins"], "56993": ["Mitochondrial protein import", "Pink/Parkin Mediated Mitophagy"], "56994": ["Synthesis of PC"], "56995": ["Neddylation"], "56998": ["Deactivation of the beta-catenin transactivating complex"], "56999": ["Degradation of the extracellular matrix", "Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "570": ["Recycling of bile acids and salts", "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Peroxisomal protein import", "Peroxisomal protein import"], "5700": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "57007": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "5701": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "Neutrophil degranulation", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "57016": ["Retinoid metabolism and transport"], "57017": ["Ubiquinol biosynthesis"], "57019": ["Cytosolic iron-sulfur cluster assembly"], "5702": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "Neutrophil degranulation", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "57020": ["Neutrophil degranulation"], "57030": ["Glutamate Neurotransmitter Release Cycle", "Organic anion transporters"], "57038": ["Mitochondrial tRNA aminoacylation"], "5704": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "5705": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "57050": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "5706": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "57060": ["TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "Transcriptional activation of cell cycle inhibitor p21 ", "FOXO-mediated transcription of cell cycle genes"], "5707": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "Neutrophil degranulation", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "5708": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "Neutrophil degranulation", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "57082": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Deposition of new CENPA-containing nucleosomes at the centromere", "Mitotic Prometaphase"], "57084": ["Organic anion transporters"], "57085": ["Signaling by BRAF and RAF fusions"], "57089": ["Phosphate bond hydrolysis by NTPDase proteins"], "5709": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "Neutrophil degranulation", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "57099": ["Formation of apoptosome", "Regulation of the apoptosome activity"], "5710": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "57101": ["Stimuli-sensing channels"], "57103": ["TP53 Regulates Metabolic Genes"], "57104": ["Acyl chain remodeling of DAG and TAG", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "57105": ["Leukotriene receptors", "G alpha (q) signalling events"], "57107": ["Ubiquinol biosynthesis"], "5711": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "57110": ["Acyl chain remodelling of PE"], "57111": ["RAB geranylgeranylation"], "57113": ["Effects of PIP2 hydrolysis", "Elevation of cytosolic Ca2+ levels", "TRP channels", "Role of second messengers in netrin-1 signaling"], "57115": ["Antimicrobial peptides"], "57117": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes"], "57119": ["Antimicrobial peptides"], "57120": ["RHO GTPases regulate CFTR trafficking"], "57121": ["G alpha (q) signalling events", "G alpha (i) signalling events", "Lysosphingolipid and LPA receptors"], "57122": ["ISG15 antiviral mechanism", "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "RHO GTPases Activate Formins", "tRNA processing in the nucleus", "Mitotic Prometaphase"], "57126": ["Common Pathway of Fibrin Clot Formation", "Cell surface interactions at the vascular wall", "Neutrophil degranulation"], "57127": ["Rhesus glycoproteins mediate ammonium transport."], "57128": ["Mitochondrial iron-sulfur cluster biogenesis"], "57129": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "5713": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "Neutrophil degranulation", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "57130": ["Ion transport by P-type ATPases"], "57134": ["Intra-Golgi traffic", "Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2"], "5714": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "57142": ["Axonal growth inhibition (RHOA activation)"], "57144": ["Activation of RAC1"], "57148": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane"], "5715": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "57153": ["Synthesis of PC", "Transport of bile salts and organic acids, metal ions and amine compounds", "Neutrophil degranulation"], "57154": ["Signaling by BMP", "Downregulation of TGF-beta receptor signaling", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "Asymmetric localization of PCP proteins", "Hedgehog 'on' state", "Hedgehog 'on' state", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Antigen processing: Ubiquitination & Proteasome degradation"], "5716": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "57161": ["Interleukin-1 signaling", "IRAK1 recruits IKK complex", "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation"], "57162": ["Interleukin-1 signaling", "IRAK1 recruits IKK complex", "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation"], "57165": ["Gap junction assembly"], "57167": ["POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation", "Transcriptional regulation of pluripotent stem cells", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription"], "5717": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "Neutrophil degranulation", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "57171": ["Synthesis of Dolichyl-phosphate"], "57176": ["Mitochondrial tRNA aminoacylation"], "5718": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "Neutrophil degranulation", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "57181": ["Zinc influx into cells by the SLC39 gene family"], "57185": ["Miscellaneous transport and binding events"], "57186": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane"], "57187": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA 3'-end processing"], "57188": ["Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "5719": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "Neutrophil degranulation", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "57192": ["TRP channels", "Transferrin endocytosis and recycling"], "57194": ["Ion transport by P-type ATPases"], "57198": ["Ion transport by P-type ATPases"], "572": ["Activation of BAD and translocation to mitochondria ", "Activation of BAD and translocation to mitochondria ", "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "NRAGE signals death through JNK", "AKT phosphorylates targets in the cytosol", "Constitutive Signaling by AKT1 E17K in Cancer"], "5720": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "57205": ["Ion transport by P-type ATPases"], "57209": ["Generic Transcription Pathway"], "5721": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "57214": ["Hyaluronan biosynthesis and export"], "57216": ["PCP/CE pathway", "Asymmetric localization of PCP proteins"], "5723": ["Serine biosynthesis"], "5724": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (q) signalling events", "Interleukin-10 signaling", "Neutrophil degranulation", "Interferon gamma signaling"], "5725": ["FGFR2 alternative splicing", "mRNA Splicing - Major Pathway", "Processing of Capped Intron-Containing Pre-mRNA"], "5726": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "5727": ["Class B/2 (Secretin family receptors)", "Hedgehog 'off' state", "Ligand-receptor interactions", "Ligand-receptor interactions", "Hedgehog 'on' state", "Hedgehog 'on' state", "Activation of SMO"], "5728": ["Synthesis of PIPs at the plasma membrane", "Synthesis of IP3 and IP4 in the cytosol", "Negative regulation of the PI3K/AKT network", "Downstream TCR signaling", "TP53 Regulates Metabolic Genes", "PTEN Loss of Function in Cancer", "Ub-specific processing proteases", "Ovarian tumor domain proteases", "Regulation of PTEN mRNA translation", "Regulation of PTEN localization", "Regulation of PTEN stability and activity", "Transcriptional Regulation by MECP2"], "57282": ["Bicarbonate transporters"], "5729": ["Prostanoid ligand receptors", "G alpha (s) signalling events"], "573": ["Regulation of HSF1-mediated heat shock response"], "5730": ["Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"], "5731": ["Prostanoid ligand receptors", "G alpha (q) signalling events"], "5732": ["Prostanoid ligand receptors", "G alpha (s) signalling events"], "57325": ["HATs acetylate histones"], "5733": ["Prostanoid ligand receptors", "G alpha (i) signalling events"], "57332": ["Oxidative Stress Induced Senescence", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of transcription cofactors", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA methylation proteins", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription"], "57335": ["Generic Transcription Pathway"], "5734": ["Prostanoid ligand receptors", "G alpha (s) signalling events"], "57343": ["Generic Transcription Pathway"], "57348": ["Stimuli-sensing channels"], "57369": ["Electric Transmission Across Gap Junctions", "Gap junction assembly"], "5737": ["Prostanoid ligand receptors", "G alpha (q) signalling events"], "57380": ["Miscellaneous transport and binding events"], "57381": ["Rho GTPase cycle"], "5739": ["Prostanoid ligand receptors", "Prostacyclin signalling through prostacyclin receptor", "Prostacyclin signalling through prostacyclin receptor", "G alpha (s) signalling events"], "57393": ["Insulin processing"], "5740": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of bile acids and bile salts via 24-hydroxycholesterol", "Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "Nicotinamide salvaging", "Eicosanoids", "Sterols are 12-hydroxylated by CYP8B1", "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"], "57403": ["RAB geranylgeranylation"], "57405": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "57406": ["Arachidonate production from DAG"], "57407": ["Urea cycle"], "5741": ["Class B/2 (Secretin family receptors)", "G alpha (s) signalling events"], "57412": ["Methylation"], "57418": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "57419": ["Sodium/Calcium exchangers"], "5742": ["COX reactions", "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"], "5743": ["Nicotinamide salvaging", "Synthesis of 15-eicosatetraenoic acid derivatives", "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "Interleukin-10 signaling", "Interleukin-4 and Interleukin-13 signaling", "Biosynthesis of DHA-derived SPMs", "Biosynthesis of EPA-derived SPMs", "Biosynthesis of DPAn-3 SPMs", "Biosynthesis of electrophilic \u03c9-3 PUFA oxo-derivatives"], "5744": ["Class B/2 (Secretin family receptors)", "G alpha (s) signalling events"], "57449": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "5745": ["Class B/2 (Secretin family receptors)", "G alpha (s) signalling events"], "57452": ["O-linked glycosylation of mucins"], "57453": ["DSCAM interactions"], "574537": ["Glucuronidation"], "57459": ["HDACs deacetylate histones", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "Regulation of TP53 Activity through Acetylation", "RNA Polymerase I Transcription Initiation", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription"], "5746": ["Class B/2 (Secretin family receptors)", "G alpha (s) signalling events"], "57461": ["Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "mRNA Splicing - Major Pathway"], "57465": ["TBC/RABGAPs"], "57468": ["Cation-coupled Chloride cotransporters"], "5747": ["Apoptotic cleavage of cellular proteins", "Regulation of actin dynamics for phagocytic cup formation", "Integrin alphaIIb beta3 signaling", "GRB2:SOS provides linkage to MAPK signaling for Integrins ", "p130Cas linkage to MAPK signaling for integrins", "NCAM signaling for neurite out-growth", "NCAM signaling for neurite out-growth", "Signal regulatory protein family interactions", "EPHB-mediated forward signaling", "EPHB-mediated forward signaling", "DCC mediated attractive signaling", "DCC mediated attractive signaling", "VEGFA-VEGFR2 Pathway", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate WASPs and WAVEs", "RAF/MAP kinase cascade", "MET activates PTK2 signaling"], "57472": ["Deadenylation of mRNA", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "57474": ["Generic Transcription Pathway"], "57486": ["Peptide ligand-binding receptors"], "57488": ["Glycosphingolipid metabolism"], "57491": ["PPARA activates gene expression", "Phase I - Functionalization of compounds", "Endogenous sterols", "Xenobiotics", "Aryl hydrocarbon receptor signalling"], "57492": ["RMTs methylate histone arginines", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "57494": ["Amino acid synthesis and interconversion (transamination)"], "57497": ["Synaptic adhesion-like molecules"], "57498": ["ARMS-mediated activation", "ARMS-mediated activation"], "57502": ["Neurexins and neuroligins", "Neurexins and neuroligins"], "57504": ["HDACs deacetylate histones", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "RNA Polymerase I Transcription Initiation", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription"], "57505": ["Mitochondrial tRNA aminoacylation"], "57506": ["DDX58/IFIH1-mediated induction of interferon-alpha/beta", "Ovarian tumor domain proteases", "TRAF3-dependent IRF activation pathway", "TRAF6 mediated IRF7 activation", "TRAF6 mediated NF-kB activation", "TRAF6 mediated NF-kB activation", "NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10", "Negative regulators of DDX58/IFIH1 signaling", "Negative regulators of DDX58/IFIH1 signaling"], "57508": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes"], "57510": ["MicroRNA (miRNA) biogenesis"], "57511": ["COPI-mediated anterograde transport", "Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network"], "57514": ["Rho GTPase cycle"], "57515": ["Serine biosynthesis"], "57520": ["Antigen processing: Ubiquitination & Proteasome degradation"], "57521": ["Macroautophagy", "mTOR signalling", "mTORC1-mediated signalling", "HSF1-dependent transactivation", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Regulation of PTEN gene transcription"], "57522": ["Rho GTPase cycle", "Inactivation of CDC42 and RAC1"], "5753": ["SCF(Skp2)-mediated degradation of p27/p21", "Cyclin D associated events in G1", "ERBB2 Activates PTK6 Signaling", "PTK6 Regulates Proteins Involved in RNA Processing", "PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "PTK6 Regulates Cell Cycle", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "PTK6 Down-Regulation", "PTK6 Expression", "PTK6 Activates STAT3", "PTK6 promotes HIF1A stabilization"], "57530": ["TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)"], "57531": ["Antigen processing: Ubiquitination & Proteasome degradation"], "57533": ["TBC/RABGAPs"], "57534": ["Activated NOTCH1 Transmits Signal to the Nucleus", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "NOTCH2 Activation and Transmission of Signal to the Nucleus", "NOTCH3 Activation and Transmission of Signal to the Nucleus"], "57539": ["Hedgehog 'off' state", "Intraflagellar transport"], "57541": ["Generic Transcription Pathway"], "57542": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "57545": ["Anchoring of the basal body to the plasma membrane"], "57546": ["Regulation of pyruvate dehydrogenase (PDH) complex"], "57547": ["Generic Transcription Pathway"], "57551": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "57552": ["LDL clearance"], "57554": ["Unblocking of NMDA receptors, glutamate binding and activation", "Unblocking of NMDA receptors, glutamate binding and activation", "Ras activation upon Ca2+ influx through NMDA receptor", "RAF/MAP kinase cascade", "Neutrophil degranulation", "Negative regulation of NMDA receptor-mediated neuronal transmission", "Long-term potentiation"], "57555": ["Neurexins and neuroligins", "Neurexins and neuroligins"], "57556": ["Other semaphorin interactions"], "57559": ["Metalloprotease DUBs"], "57560": ["Intraflagellar transport", "Intraflagellar transport"], "57569": ["Rho GTPase cycle"], "57570": ["Synthesis of wybutosine at G37 of tRNA(Phe)"], "57571": ["Histidine catabolism"], "57572": ["Factors involved in megakaryocyte development and platelet production"], "57573": ["Generic Transcription Pathway"], "57576": ["Intraflagellar transport"], "57578": ["Stimuli-sensing channels"], "57580": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "57584": ["Rho GTPase cycle"], "57589": ["Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network", "RAB GEFs exchange GTP for GDP on RABs"], "57591": ["SUMOylation of transcription cofactors", "RHO GTPases Activate Formins"], "57596": ["Neurexins and neuroligins"], "57599": ["Recognition of DNA damage by PCNA-containing replication complex", "Ub-specific processing proteases", "Fanconi Anemia Pathway"], "57604": ["tRNA modification in the nucleus and cytosol"], "57605": ["Synthesis of PI"], "57610": ["MET activates RAS signaling"], "57615": ["Generic Transcription Pathway"], "57622": ["Synaptic adhesion-like molecules"], "57630": ["Antigen processing: Ubiquitination & Proteasome degradation"], "57634": ["Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "DNA Damage/Telomere Stress Induced Senescence", "HATs acetylate histones"], "57636": ["Rho GTPase cycle"], "57642": ["Collagen biosynthesis and modifying enzymes", "Collagen chain trimerization"], "57646": ["Ub-specific processing proteases"], "57647": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "57654": ["Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER"], "57657": ["HCN channels"], "57664": ["Synthesis of PIPs at the plasma membrane"], "57665": ["RA biosynthesis pathway"], "57669": ["Neurexins and neuroligins"], "57670": ["Signaling by BRAF and RAF fusions"], "57674": ["Antigen processing: Ubiquitination & Proteasome degradation"], "57677": ["Generic Transcription Pathway"], "57678": ["Synthesis of PA", "Activation of gene expression by SREBF (SREBP)", "Triglyceride biosynthesis", "RUNX1 regulates estrogen receptor mediated transcription", "Estrogen-dependent gene expression"], "57679": ["RAB GEFs exchange GTP for GDP on RABs"], "5768": ["Platelet degranulation ", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Neutrophil degranulation", "Post-translational protein phosphorylation"], "57680": ["Deactivation of the beta-catenin transactivating complex"], "57690": ["Pre-NOTCH Transcription and Translation", "Oxidative Stress Induced Senescence", "Oncogene Induced Senescence", "Ca2+ pathway", "Post-transcriptional silencing by small RNAs", "TP53 Regulates Metabolic Genes", "MAPK6/MAPK4 signaling", "Regulation of RUNX1 Expression and Activity", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Regulation of PTEN mRNA translation", "Competing endogenous RNAs (ceRNAs) regulate PTEN translation", "Transcriptional Regulation by MECP2", "Transcriptional Regulation by MECP2", "Estrogen-dependent gene expression", "Regulation of MECP2 expression and activity"], "57693": ["Generic Transcription Pathway"], "57695": ["Ub-specific processing proteases"], "57697": ["Fanconi Anemia Pathway"], "57698": ["Recycling pathway of L1"], "5770": ["Integrin alphaIIb beta3 signaling", "Negative regulation of MET activity", "Regulation of IFNG signaling", "PTK6 Down-Regulation", "MECP2 regulates neuronal receptors and channels", "Regulation of IFNA signaling", "Growth hormone receptor signaling", "Growth hormone receptor signaling"], "57703": ["mRNA Splicing - Major Pathway"], "57704": ["Glycosphingolipid metabolism"], "57706": ["RAB GEFs exchange GTP for GDP on RABs"], "5771": ["Negative regulation of MET activity", "Regulation of IFNG signaling", "Interleukin-37 signaling"], "57711": ["Generic Transcription Pathway"], "57719": ["Stimuli-sensing channels", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "57721": ["Processing of Capped Intron-Containing Pre-mRNA"], "57728": ["Hedgehog 'off' state", "Intraflagellar transport"], "57731": ["NCAM signaling for neurite out-growth", "NCAM signaling for neurite out-growth", "Interaction between L1 and Ankyrins", "Interaction between L1 and Ankyrins", "RAF/MAP kinase cascade", "COPI-mediated anterograde transport"], "57733": ["Glycosphingolipid metabolism"], "5774": ["EGFR downregulation"], "5775": ["Toll Like Receptor 4 (TLR4) Cascade", "Interleukin-37 signaling", "MECP2 regulates neuronal receptors and channels"], "57758": ["Release of Hh-Np from the secreting cell"], "57761": ["PIP3 activates AKT signaling", "Activation of AKT2", "PPARA activates gene expression", "Negative regulation of the PI3K/AKT network", "CD28 dependent PI3K/Akt signaling", "VEGFR2 mediated vascular permeability"], "5777": ["GPVI-mediated activation cascade", "Regulation of KIT signaling", "PECAM1 interactions", "Costimulation by the CD28 family", "PD-1 signaling", "Signal regulatory protein family interactions", "Platelet sensitization by LDL", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "CD22 mediated BCR regulation", "Neutrophil degranulation", "Interferon gamma signaling", "Regulation of IFNG signaling", "Interleukin-37 signaling", "Interferon alpha/beta signaling", "Interleukin receptor SHC signaling", "Regulation of IFNA signaling", "Growth hormone receptor signaling", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "5778": ["Interleukin-37 signaling"], "57787": ["Anchoring of the basal body to the plasma membrane"], "57794": ["mRNA Splicing - Major Pathway"], "57799": ["RAB geranylgeranylation"], "578": ["Activation and oligomerization of BAK protein", "Release of apoptotic factors from the mitochondria"], "5780": ["Interleukin-37 signaling"], "57804": ["Recognition of DNA damage by PCNA-containing replication complex", "Polymerase switching on the C-strand of the telomere", "Processive synthesis on the C-strand of the telomere", "Telomere C-strand (Lagging Strand) Synthesis", "Removal of the Flap Intermediate from the C-strand", "Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "PCNA-Dependent Long Patch Base Excision Repair", "Termination of translesion DNA synthesis", "HDR through Homologous Recombination (HRR)", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Polymerase switching", "Removal of the Flap Intermediate", "Processive synthesis on the lagging strand"], "57805": ["Regulation of HSF1-mediated heat shock response"], "5781": ["Interleukin-6 signaling", "PI3K Cascade", "MAPK3 (ERK1) activation", "MAPK1 (ERK2) activation", "GPVI-mediated activation cascade", "Prolactin receptor signaling", "PIP3 activates AKT signaling", "Spry regulation of FGF signaling", "Signaling by SCF-KIT", "GAB1 signalosome", "Downstream signal transduction", "PECAM1 interactions", "Tie2 Signaling", "Constitutive Signaling by Aberrant PI3K in Cancer", "Signaling by Leptin", "Costimulation by the CD28 family", "CTLA4 inhibitory signaling", "PD-1 signaling", "Signal regulatory protein family interactions", "Netrin mediated repulsion signals", "Platelet sensitization by LDL", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "FRS-mediated FGFR2 signaling", "FRS-mediated FGFR3 signaling", "PI-3K cascade:FGFR3", "FRS-mediated FGFR4 signaling", "PI-3K cascade:FGFR4", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Regulation of IFNG signaling", "RET signaling", "Interleukin-20 family signaling", "MET activates PTPN11", "Regulation of RUNX1 Expression and Activity", "Interleukin-37 signaling", "Activated NTRK2 signals through FRS2 and FRS3", "Interferon alpha/beta signaling", "Regulation of IFNA signaling", "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon"], "57818": ["Gluconeogenesis"], "57819": ["mRNA decay by 5' to 3' exoribonuclease", "mRNA decay by 5' to 3' exoribonuclease", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "5782": ["SHC1 events in ERBB2 signaling", "SHC1 events in ERBB2 signaling", "EGFR downregulation", "Signaling by PDGF", "Downregulation of ERBB2 signaling", "Interleukin-37 signaling"], "57823": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "57826": ["Neutrophil degranulation"], "57828": ["Sperm Motility And Taxes"], "57829": ["Interaction With The Zona Pellucida"], "5783": ["Synthesis of PIPs at the plasma membrane", "Interleukin-37 signaling"], "57830": ["Keratinization"], "57834": ["Fatty acids", "Miscellaneous substrates", "Eicosanoids", "Synthesis of Leukotrienes (LT) and Eoxins (EX)"], "57835": ["Bicarbonate transporters"], "5784": ["Interleukin-37 signaling"], "5786": ["NCAM signaling for neurite out-growth", "NCAM signaling for neurite out-growth", "RAF/MAP kinase cascade"], "57863": ["Adherens junctions interactions", "Nectin/Necl trans heterodimerization"], "5787": ["Neutrophil degranulation"], "5788": ["Phosphorylation of CD3 and TCR zeta chains", "Other semaphorin interactions", "Neutrophil degranulation"], "5789": ["Receptor-type tyrosine-protein phosphatases", "Synaptic adhesion-like molecules"], "579": ["Regulation of RUNX2 expression and activity"], "5792": ["Receptor-type tyrosine-protein phosphatases", "Synaptic adhesion-like molecules"], "5795": ["Phosphorylation of CD3 and TCR zeta chains", "Neutrophil degranulation", "Negative regulation of MET activity"], "5796": ["EGFR downregulation"], "5799": ["Neutrophil degranulation"], "58": ["Striated Muscle Contraction"], "580": ["HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "UCH proteinases", "Metalloprotease DUBs", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Nonhomologous End-Joining (NHEJ)", "Homologous DNA Pairing and Strand Exchange", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Regulation of TP53 Activity through Phosphorylation", "G2/M DNA damage checkpoint"], "5800": ["Signaling by NTRK3 (TRKC)"], "5802": ["ECM proteoglycans", "Receptor-type tyrosine-protein phosphatases", "Synaptic adhesion-like molecules", "Signaling by NTRK3 (TRKC)"], "5803": ["Other interleukin signaling"], "5805": ["Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation"], "5806": ["Neutrophil degranulation"], "581": ["Release of apoptotic factors from the mitochondria", "Activation, translocation and oligomerization of BAX", "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "Transcriptional regulation by RUNX2", "NTRK3 as a dependence receptor"], "5810": ["Activation of ATR in response to replication stress", "HDR through Single Strand Annealing (SSA)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Regulation of TP53 Activity through Phosphorylation", "G2/M DNA damage checkpoint"], "58157": ["Intracellular oxygen transport"], "5816": ["Transcriptional Regulation by MECP2"], "5817": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Nectin/Necl trans heterodimerization"], "5818": ["Adherens junctions interactions", "Nectin/Necl trans heterodimerization"], "5819": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Adherens junctions interactions", "Nectin/Necl trans heterodimerization"], "58191": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "582": ["BBSome-mediated cargo-targeting to cilium"], "5822": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "5824": ["ABC transporters in lipid homeostasis"], "5825": ["ABC transporters in lipid homeostasis"], "5826": ["Cobalamin (Cbl, vitamin B12) transport and metabolism", "Defective ABCD4 causes methylmalonic aciduria and homocystinuria, cblj type (MAHCJ)"], "5827": ["Glyoxylate metabolism and glycine degradation"], "5828": ["E3 ubiquitin ligases ubiquitinate target proteins", "Peroxisomal protein import", "Peroxisomal protein import"], "5829": ["GAB1 signalosome", "VEGFA-VEGFR2 Pathway", "Smooth Muscle Contraction", "Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases"], "583": ["BBSome-mediated cargo-targeting to cilium"], "5830": ["E3 ubiquitin ligases ubiquitinate target proteins", "Peroxisomal protein import", "Peroxisomal protein import"], "5831": ["Amino acid synthesis and interconversion (transamination)"], "5832": ["Amino acid synthesis and interconversion (transamination)"], "5833": ["Synthesis of PE"], "5834": ["Neutrophil degranulation", "Glycogen breakdown (glycogenolysis)"], "5836": ["Neutrophil degranulation", "Glycogen breakdown (glycogenolysis)"], "5837": ["Glycogen breakdown (glycogenolysis)", "Glycogen breakdown (glycogenolysis)"], "58472": ["Sulfide oxidation to sulfate", "Sulfide oxidation to sulfate"], "58477": ["SRP-dependent cotranslational protein targeting to membrane", "XBP1(S) activates chaperone genes"], "58478": ["Methionine salvage pathway"], "58480": ["Rho GTPase cycle", "Interleukin-4 and Interleukin-13 signaling"], "58484": ["TP53 Regulates Transcription of Caspase Activators and Caspases", "The IPAF inflammasome", "The IPAF inflammasome"], "58485": ["COPII-mediated vesicle transport", "Neutrophil degranulation", "RAB GEFs exchange GTP for GDP on RABs"], "58488": ["Synthesis of PC", "Mitochondrial Fatty Acid Beta-Oxidation"], "58490": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes"], "58491": ["Generic Transcription Pathway"], "58492": ["Generic Transcription Pathway"], "58494": ["Cell surface interactions at the vascular wall", "Integrin cell surface interactions"], "58498": ["Smooth Muscle Contraction"], "585": ["BBSome-mediated cargo-targeting to cilium"], "58500": ["Generic Transcription Pathway"], "58504": ["Rho GTPase cycle"], "58508": ["PKMTs methylate histone lysines", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"], "58510": ["Glyoxylate metabolism and glycine degradation", "Proline catabolism"], "58512": ["Neurexins and neuroligins", "Neurexins and neuroligins"], "58513": ["EGFR downregulation", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "58526": ["Import of palmitoyl-CoA into the mitochondrial matrix"], "58528": ["Macroautophagy", "mTOR signalling", "mTORC1-mediated signalling", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Regulation of PTEN gene transcription"], "58530": ["Post-translational modification: synthesis of GPI-anchored proteins"], "5859": ["SeMet incorporation into proteins", "Cytosolic tRNA aminoacylation", "Mitochondrial tRNA aminoacylation"], "586": ["Branched-chain amino acid catabolism"], "5860": ["Phenylalanine and tyrosine catabolism"], "5861": ["Golgi Cisternae Pericentriolar Stack Reorganization", "Golgi Cisternae Pericentriolar Stack Reorganization", "COPII-mediated vesicle transport", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "5862": ["Golgi Cisternae Pericentriolar Stack Reorganization", "RAB geranylgeranylation"], "5864": ["Serotonin Neurotransmitter Release Cycle", "Norepinephrine Neurotransmitter Release Cycle", "Glutamate Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle", "Acetylcholine Neurotransmitter Release Cycle", "Neutrophil degranulation", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs", "GABA synthesis, release, reuptake and degradation"], "5865": ["RAB geranylgeranylation"], "5866": ["RAB GEFs exchange GTP for GDP on RABs"], "5867": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Synthesis of PIPs at the plasma membrane", "TBC/RABGAPs", "RAB geranylgeranylation", "MET receptor recycling"], "5868": ["Synthesis of PIPs at the plasma membrane", "TBC/RABGAPs", "Clathrin-mediated endocytosis", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs", "Factors involved in megakaryocyte development and platelet production"], "5869": ["Neutrophil degranulation", "TBC/RABGAPs", "Clathrin-mediated endocytosis", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "587": ["Branched-chain amino acid catabolism"], "5870": ["Pre-NOTCH Processing in Golgi", "Neutrophil degranulation", "COPI-independent Golgi-to-ER retrograde traffic", "Retrograde transport at the Trans-Golgi-Network", "TBC/RABGAPs", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "5872": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "5873": ["Insulin processing", "Neutrophil degranulation", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "5874": ["Platelet degranulation ", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "5875": ["TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "RAB geranylgeranylation"], "5876": ["TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "RAB geranylgeranylation"], "5878": ["Golgi Associated Vesicle Biogenesis", "Neutrophil degranulation", "TBC/RABGAPs", "Clathrin-mediated endocytosis", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "5879": ["GPVI-mediated activation cascade", "PIP3 activates AKT signaling", "Signaling by SCF-KIT", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Nef and signal transduction", "NRAGE signals death through JNK", "Rho GTPase cycle", "Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "Constitutive Signaling by Aberrant PI3K in Cancer", "DAP12 signaling", "FCERI mediated MAPK activation", "DSCAM interactions", "CD28 dependent Vav1 pathway", "EPHB-mediated forward signaling", "Ephrin signaling", "EPH-ephrin mediated repulsion of cells", "Sema3A PAK dependent Axon repulsion", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "PCP/CE pathway", "Sema4D mediated inhibition of cell attachment and migration", "DCC mediated attractive signaling", "DCC mediated attractive signaling", "Activation of RAC1", "Inactivation of CDC42 and RAC1", "VEGFA-VEGFR2 Pathway", "Signal transduction by L1", "VEGFR2 mediated vascular permeability", "RHO GTPases activate PKNs", "RHO GTPases activate CIT", "RHO GTPases activate CIT", "RHO GTPases activate KTN1", "RHO GTPases activate IQGAPs", "RHO GTPases activate PAKs", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate Formins", "RHO GTPases Activate Formins", "RHO GTPases Activate NADPH Oxidases", "MAPK6/MAPK4 signaling", "Neutrophil degranulation", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "MET activates RAP1 and RAC1", "NTRK2 activates RAC1", "Activated NTRK2 signals through CDK5", "Activation of RAC1 downstream of NMDARs", "Factors involved in megakaryocyte development and platelet production"], "5880": ["GPVI-mediated activation cascade", "ROS, RNS production in phagocytes", "PIP3 activates AKT signaling", "Rho GTPase cycle", "Constitutive Signaling by Aberrant PI3K in Cancer", "PCP/CE pathway", "RHO GTPases Activate NADPH Oxidases", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "5881": ["Rho GTPase cycle", "PCP/CE pathway"], "5883": ["Activation of ATR in response to replication stress", "HDR through Single Strand Annealing (SSA)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Regulation of TP53 Activity through Phosphorylation", "G2/M DNA damage checkpoint"], "5884": ["Activation of ATR in response to replication stress", "HDR through Single Strand Annealing (SSA)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Regulation of TP53 Activity through Phosphorylation", "G2/M DNA damage checkpoint"], "5885": ["Meiotic synapsis", "Separation of Sister Chromatids", "Establishment of Sister Chromatid Cohesion", "Cohesin Loading onto Chromatin", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA damage response and repair proteins", "Estrogen-dependent gene expression"], "5886": ["Josephin domain DUBs", "DNA Damage Recognition in GG-NER", "Formation of Incision Complex in GG-NER"], "5887": ["N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "Josephin domain DUBs", "DNA Damage Recognition in GG-NER", "Formation of Incision Complex in GG-NER"], "5888": ["HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange", "Presynaptic phase of homologous DNA pairing and strand exchange", "Transcriptional Regulation by E2F6", "Meiotic recombination"], "5889": ["HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange", "Presynaptic phase of homologous DNA pairing and strand exchange", "Meiotic recombination", "Factors involved in megakaryocyte development and platelet production"], "5890": ["HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange", "Presynaptic phase of homologous DNA pairing and strand exchange", "Factors involved in megakaryocyte development and platelet production"], "5892": ["HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange", "Presynaptic phase of homologous DNA pairing and strand exchange", "TP53 Regulates Transcription of DNA Repair Genes"], "5893": ["SUMOylation of DNA damage response and repair proteins", "HDR through Single Strand Annealing (SSA)"], "5894": ["Stimuli-sensing channels", "Rap1 signalling", "GP1b-IX-V activation signalling", "CD209 (DC-SIGN) signaling", "RAF activation", "MAP2K and MAPK activation", "Negative feedback regulation of MAPK pathway", "Negative regulation of MAPK pathway", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF"], "5896": ["Interleukin-7 signaling", "MAPK6/MAPK4 signaling"], "5897": ["Interleukin-7 signaling", "MAPK6/MAPK4 signaling"], "5898": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "p38MAPK events", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "58985": ["Interleukin-20 family signaling"], "5899": ["p38MAPK events"], "59": ["Smooth Muscle Contraction", "NOTCH4 Intracellular Domain Regulates Transcription"], "590": ["Neurotransmitter clearance", "Synthesis of PC", "Synthesis, secretion, and deacylation of Ghrelin"], "5900": ["p38MAPK events", "p38MAPK events"], "5901": ["Rev-mediated nuclear export of HIV RNA", "Regulation of cholesterol biosynthesis by SREBP (SREBF)", "NEP/NS2 Interacts with the Cellular Export Machinery", "Nuclear import of Rev protein", "MicroRNA (miRNA) biogenesis", "Transcriptional regulation by small RNAs", "tRNA processing in the nucleus"], "5902": ["Rev-mediated nuclear export of HIV RNA"], "5903": ["ISG15 antiviral mechanism", "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "RHO GTPases Activate Formins", "tRNA processing in the nucleus", "Mitotic Prometaphase"], "5905": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Rev-mediated nuclear export of HIV RNA", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA replication proteins", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "5906": ["Frs2-mediated activation", "ARMS-mediated activation", "ARMS-mediated activation", "Integrin alphaIIb beta3 signaling", "GRB2:SOS provides linkage to MAPK signaling for Integrins ", "p130Cas linkage to MAPK signaling for integrins", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Rap1 signalling", "MAP2K and MAPK activation", "Neutrophil degranulation", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF", "MET activates RAP1 and RAC1"], "59067": ["Interleukin-21 signaling"], "5908": ["Integrin alphaIIb beta3 signaling", "GRB2:SOS provides linkage to MAPK signaling for Integrins ", "p130Cas linkage to MAPK signaling for integrins", "Rap1 signalling", "MAP2K and MAPK activation", "Neutrophil degranulation", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF", "MET activates RAP1 and RAC1", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "5909": ["Rap1 signalling", "RET signaling"], "5912": ["Neutrophil degranulation"], "5914": ["Nuclear Receptor transcription pathway", "SUMOylation of intracellular receptors", "Signaling by Retinoic Acid", "Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "5915": ["Nuclear Receptor transcription pathway", "Signaling by Retinoic Acid", "Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "5916": ["Nuclear Receptor transcription pathway", "Signaling by Retinoic Acid", "Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "5917": ["SeMet incorporation into proteins", "Cytosolic tRNA aminoacylation"], "5919": ["Platelet degranulation "], "5920": ["Acyl chain remodelling of PE"], "5921": ["Downstream signal transduction", "EPHB-mediated forward signaling", "EPHB-mediated forward signaling", "VEGFR2 mediated cell proliferation", "Regulation of RAS by GAPs", "Signaling by RAS mutants", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases"], "5922": ["Regulation of RAS by GAPs", "Signaling by RAS mutants"], "5923": ["Ras activation upon Ca2+ influx through NMDA receptor", "RAF/MAP kinase cascade"], "5924": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events", "Ras activation upon Ca2+ influx through NMDA receptor", "RAF/MAP kinase cascade"], "5925": ["Inhibition of replication initiation of damaged DNA by RB1/E2F1", "Inhibition of replication initiation of damaged DNA by RB1/E2F1", "Condensation of Prophase Chromosomes", "Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "Oncogene Induced Senescence", "Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes", "Cyclin E associated events during G1/S transition ", "Cyclin D associated events in G1", "Cyclin A:Cdk2-associated events at S phase entry", "RUNX2 regulates osteoblast differentiation"], "5926": ["HDACs deacetylate histones"], "59269": ["Regulation of RUNX2 expression and activity"], "5927": ["HDMs demethylate histones"], "59272": ["Metabolism of Angiotensinogen to Angiotensins"], "59277": ["Non-integrin membrane-ECM interactions", "Netrin-1 signaling"], "5928": ["Transcription of E2F targets under negative control by DREAM complex", "Transcription of E2F targets under negative control by DREAM complex", "Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1", "G0 and Early G1", "Polo-like kinase mediated events", "PRC2 methylates histones and DNA", "Oxidative Stress Induced Senescence", "HDACs deacetylate histones", "PKMTs methylate histone lysines", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "Activation of E2F1 target genes at G1/S", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Deposition of new CENPA-containing nucleosomes at the centromere", "Regulation of TP53 Activity through Acetylation", "Cyclin E associated events during G1/S transition ", "Cyclin A:Cdk2-associated events at S phase entry", "RNA Polymerase I Transcription Initiation", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription", "Transcriptional Regulation by E2F6"], "59283": ["Trafficking of AMPA receptors", "Phase 0 - rapid depolarisation", "Phase 2 - plateau phase", "LGI-ADAM interactions"], "59284": ["Phase 0 - rapid depolarisation", "Phase 2 - plateau phase"], "59285": ["Phase 0 - rapid depolarisation", "Phase 2 - plateau phase"], "5929": ["Formation of the beta-catenin:TCF transactivating complex", "PKMTs methylate histone lysines", "Deactivation of the beta-catenin transactivating complex", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Neddylation"], "593": ["Glyoxylate metabolism and glycine degradation", "Branched-chain amino acid catabolism"], "5930": ["Antigen processing: Ubiquitination & Proteasome degradation"], "59307": ["MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "Interleukin-37 signaling"], "5931": ["PRC2 methylates histones and DNA", "Oxidative Stress Induced Senescence", "HDACs deacetylate histones", "PKMTs methylate histone lysines", "HATs acetylate histones", "RMTs methylate histone arginines", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Deposition of new CENPA-containing nucleosomes at the centromere", "Regulation of TP53 Activity through Acetylation", "RNA Polymerase I Transcription Initiation", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription", "Neddylation", "Transcriptional Regulation by E2F6"], "5932": ["HDR through Single Strand Annealing (SSA)", "HDR through MMEJ (alt-NHEJ)", "HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Regulation of TP53 Activity through Phosphorylation", "G2/M DNA damage checkpoint", "Transcriptional Regulation by E2F6", "Meiotic recombination"], "5933": ["Transcription of E2F targets under negative control by DREAM complex", "Transcription of E2F targets under negative control by DREAM complex", "Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1", "G0 and Early G1", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Activation of E2F1 target genes at G1/S", "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "Cyclin D associated events in G1"], "59338": ["Synthesis of PIPs at the plasma membrane"], "59339": ["Synthesis of PIPs at the plasma membrane"], "5934": ["Transcription of E2F targets under negative control by DREAM complex", "Transcription of E2F targets under negative control by DREAM complex", "Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1", "G0 and Early G1", "Activation of E2F1 target genes at G1/S", "Activation of E2F1 target genes at G1/S", "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "Cyclin E associated events during G1/S transition ", "Cyclin D associated events in G1", "Cyclin A:Cdk2-associated events at S phase entry", "FOXO-mediated transcription of cell cycle genes"], "59340": ["Histamine receptors", "G alpha (i) signalling events"], "59341": ["TRP channels"], "59343": ["SUMO is proteolytically processed"], "59344": ["Synthesis of 12-eicosatetraenoic acid derivatives"], "59345": ["Glucagon signaling in metabolic regulation", "G-protein activation", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42"], "59348": ["Generic Transcription Pathway", "SUMOylation of transcription cofactors"], "59349": ["Degradation of DVL"], "59350": ["G alpha (s) signalling events", "Relaxin receptors"], "59352": ["Regulation of FZD by ubiquitination"], "5936": ["Circadian Clock"], "594": ["Glyoxylate metabolism and glycine degradation", "Branched-chain amino acid catabolism"], "5947": ["Retinoid cycle disease events", "The canonical retinoid cycle in rods (twilight vision)", "Retinoid metabolism and transport"], "5948": ["Retinoid metabolism and transport"], "594857": ["Peptide ligand-binding receptors", "G alpha (q) signalling events", "G alpha (s) signalling events"], "5949": ["The retinoid cycle in cones (daylight vision)", "The canonical retinoid cycle in rods (twilight vision)"], "595": ["SCF(Skp2)-mediated degradation of p27/p21", "Pre-NOTCH Transcription and Translation", "RMTs methylate histone arginines", "Interleukin-4 and Interleukin-13 signaling", "Ubiquitin-dependent degradation of Cyclin D1", "Ubiquitin-dependent degradation of Cyclin D1", "Cyclin D associated events in G1", "PTK6 Regulates Cell Cycle", "Transcriptional regulation by RUNX2", "Regulation of RUNX1 Expression and Activity", "RUNX3 regulates WNT signaling", "RUNX3 regulates p14-ARF", "Estrogen-dependent gene expression"], "5950": ["Retinoid cycle disease events", "The canonical retinoid cycle in rods (twilight vision)", "Retinoid metabolism disease events", "Retinoid metabolism and transport"], "5954": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "5957": ["Inactivation, recovery and regulation of the phototransduction cascade", "Inactivation, recovery and regulation of the phototransduction cascade"], "5959": ["Retinoid cycle disease events", "The canonical retinoid cycle in rods (twilight vision)", "RA biosynthesis pathway"], "596": ["Activation of BAD and translocation to mitochondria ", "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "Interleukin-4 and Interleukin-13 signaling", "The NLRP1 inflammasome", "Estrogen-dependent gene expression"], "5962": ["Recycling pathway of L1", "Recycling pathway of L1"], "5966": ["Activation of NF-kappaB in B cells"], "5970": ["Activation of NF-kappaB in B cells", "RIP-mediated NFkB activation via ZBP1", "Regulated proteolysis of p75NTR", "Downstream TCR signaling", "NF-kB is activated and signals survival", "Senescence-Associated Secretory Phenotype (SASP)", "FCERI mediated NF-kB activation", "DEx/H-box helicases activate type I IFN and inflammatory cytokines production ", "PKMTs methylate histone lysines", "Transcriptional regulation of white adipocyte differentiation", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "Interleukin-1 processing", "SUMOylation of immune response proteins", "IkBA variant leads to EDA-ID", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "CD209 (DC-SIGN) signaling", "CLEC7A/inflammasome pathway", "The NLRP3 inflammasome", "Interleukin-1 signaling", "TRAF6 mediated NF-kB activation"], "5971": ["Dectin-1 mediated noncanonical NF-kB signaling", "CD209 (DC-SIGN) signaling", "NIK-->noncanonical NF-kB signaling"], "5972": ["Metabolism of Angiotensinogen to Angiotensins"], "5973": ["Synthesis of UDP-N-acetyl-glucosamine"], "5976": ["Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "5978": ["HDACs deacetylate histones", "Regulation of PTEN gene transcription"], "5979": ["RAF/MAP kinase cascade", "RET signaling"], "598": ["BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "Interleukin-4 and Interleukin-13 signaling", "The NLRP1 inflammasome"], "5980": ["Translesion synthesis by REV1", "Translesion synthesis by POLK", "Translesion synthesis by POLI"], "5981": ["Translesion synthesis by REV1", "Recognition of DNA damage by PCNA-containing replication complex", "Translesion Synthesis by POLH", "Polymerase switching on the C-strand of the telomere", "PCNA-Dependent Long Patch Base Excision Repair", "Translesion synthesis by POLK", "Translesion synthesis by POLI", "Termination of translesion DNA synthesis", "HDR through Homologous Recombination (HRR)", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Polymerase switching"], "5982": ["Translesion synthesis by REV1", "Recognition of DNA damage by PCNA-containing replication complex", "Translesion Synthesis by POLH", "Polymerase switching on the C-strand of the telomere", "Activation of ATR in response to replication stress", "PCNA-Dependent Long Patch Base Excision Repair", "Translesion synthesis by POLK", "Translesion synthesis by POLI", "Termination of translesion DNA synthesis", "HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Regulation of TP53 Activity through Phosphorylation", "Polymerase switching", "G2/M DNA damage checkpoint"], "5983": ["Translesion synthesis by REV1", "Recognition of DNA damage by PCNA-containing replication complex", "Translesion Synthesis by POLH", "Polymerase switching on the C-strand of the telomere", "Activation of ATR in response to replication stress", "PCNA-Dependent Long Patch Base Excision Repair", "Translesion synthesis by POLK", "Translesion synthesis by POLI", "Termination of translesion DNA synthesis", "HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Regulation of TP53 Activity through Phosphorylation", "Polymerase switching", "G2/M DNA damage checkpoint"], "5984": ["Translesion synthesis by REV1", "Recognition of DNA damage by PCNA-containing replication complex", "Translesion Synthesis by POLH", "Polymerase switching on the C-strand of the telomere", "Activation of ATR in response to replication stress", "PCNA-Dependent Long Patch Base Excision Repair", "Translesion synthesis by POLK", "Translesion synthesis by POLI", "Termination of translesion DNA synthesis", "HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Regulation of TP53 Activity through Phosphorylation", "Polymerase switching", "G2/M DNA damage checkpoint"], "5985": ["Translesion synthesis by REV1", "Recognition of DNA damage by PCNA-containing replication complex", "Translesion Synthesis by POLH", "Polymerase switching on the C-strand of the telomere", "Activation of ATR in response to replication stress", "PCNA-Dependent Long Patch Base Excision Repair", "Translesion synthesis by POLK", "Translesion synthesis by POLI", "Termination of translesion DNA synthesis", "HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Regulation of TP53 Activity through Phosphorylation", "Polymerase switching", "G2/M DNA damage checkpoint"], "5986": ["Pre-NOTCH Processing in Golgi"], "5987": ["SUMOylation of ubiquitinylation proteins", "Regulation of PTEN stability and activity"], "5995": ["G alpha (i) signalling events", "Opsins"], "5996": ["G alpha (q) signalling events", "G alpha (i) signalling events", "G alpha (i) signalling events"], "5997": ["G alpha (q) signalling events"], "5998": ["G alpha (q) signalling events", "G alpha (i) signalling events"], "5999": ["G alpha (q) signalling events", "G alpha (i) signalling events", "G alpha (i) signalling events", "G alpha (z) signalling events"], "60": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Gap junction degradation", "Formation of annular gap junctions", "Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "HATs acetylate histones", "Prefoldin mediated transfer of substrate to CCT/TriC", "Folding of actin by CCT/TriC", "EPHB-mediated forward signaling", "EPH-ephrin mediated repulsion of cells", "Adherens junctions interactions", "Adherens junctions interactions", "Recycling pathway of L1", "Recycling pathway of L1", "VEGFA-VEGFR2 Pathway", "Interaction between L1 and Ankyrins", "Interaction between L1 and Ankyrins", "Cell-extracellular matrix interactions", "B-WICH complex positively regulates rRNA expression", "RHO GTPases activate IQGAPs", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate Formins", "RHO GTPases Activate Formins", "MAP2K and MAPK activation", "UCH proteinases", "DNA Damage Recognition in GG-NER", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF", "Clathrin-mediated endocytosis", "Factors involved in megakaryocyte development and platelet production"], "6000": ["G alpha (i) signalling events", "G alpha (i) signalling events", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "6001": ["G alpha (i) signalling events", "G alpha (i) signalling events"], "6002": ["G alpha (i) signalling events", "G alpha (i) signalling events"], "6003": ["G alpha (q) signalling events", "G alpha (i) signalling events", "G alpha (i) signalling events"], "6004": ["G alpha (q) signalling events", "G alpha (i) signalling events", "G alpha (i) signalling events", "G alpha (z) signalling events"], "6005": ["Erythrocytes take up carbon dioxide and release oxygen", "Erythrocytes take up oxygen and release carbon dioxide", "Rhesus glycoproteins mediate ammonium transport.", "Defective RHAG causes regulator type Rh-null hemolytic anemia (RHN)"], "6009": ["Macroautophagy", "mTOR signalling", "mTORC1-mediated signalling", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Regulation of PTEN gene transcription"], "6010": ["The canonical retinoid cycle in rods (twilight vision)", "Activation of the phototransduction cascade", "Activation of the phototransduction cascade", "Inactivation, recovery and regulation of the phototransduction cascade", "Inactivation, recovery and regulation of the phototransduction cascade", "G alpha (i) signalling events", "Opsins", "VxPx cargo-targeting to cilium", "VxPx cargo-targeting to cilium"], "6011": ["Inactivation, recovery and regulation of the phototransduction cascade", "Inactivation, recovery and regulation of the phototransduction cascade"], "6014": ["Signalling to p38 via RIT and RIN"], "6015": ["Oxidative Stress Induced Senescence", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of transcription cofactors", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA methylation proteins", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription", "Transcriptional Regulation by E2F6"], "6016": ["Signalling to p38 via RIT and RIN"], "6017": ["The retinoid cycle in cones (daylight vision)", "The retinoid cycle in cones (daylight vision)", "Retinoid cycle disease events", "The canonical retinoid cycle in rods (twilight vision)"], "6019": ["G alpha (s) signalling events", "Relaxin receptors"], "6036": ["Neutrophil degranulation"], "6037": ["Neutrophil degranulation", "Antimicrobial peptides"], "60386": ["Vitamin B1 (thiamin) metabolism"], "6039": ["Antimicrobial peptides"], "604": ["Interleukin-4 and Interleukin-13 signaling", "TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "FOXO-mediated transcription of cell death genes"], "60401": ["TNFs bind their physiological receptors"], "6041": ["OAS antiviral response", "Interferon alpha/beta signaling"], "60412": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Insulin processing", "VxPx cargo-targeting to cilium"], "60436": ["Downregulation of SMAD2/3:SMAD4 transcriptional activity", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription"], "6045": ["Oxidative Stress Induced Senescence", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of transcription cofactors", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA methylation proteins", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription", "Transcriptional Regulation by E2F6"], "6046": ["RUNX3 regulates p14-ARF"], "6047": ["Processing of DNA double-strand break ends", "Antigen processing: Ubiquitination & Proteasome degradation"], "6048": ["ABC-family proteins mediated transport", "Defective CFTR causes cystic fibrosis", "ER Quality Control Compartment (ERQC)"], "60481": ["Linoleic acid (LA) metabolism", "alpha-linolenic acid (ALA) metabolism", "Synthesis of very long-chain fatty acyl-CoAs"], "60482": ["Acetylcholine Neurotransmitter Release Cycle", "Transport of bile salts and organic acids, metal ions and amine compounds", "Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A)", "Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A)"], "60485": ["Signaling by Hippo"], "60487": ["tRNA modification in the nucleus and cytosol"], "60488": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "60489": ["Vif-mediated degradation of APOBEC3G", "APOBEC3G mediated resistance to HIV-1 infection"], "6049": ["Antigen processing: Ubiquitination & Proteasome degradation"], "60490": ["Coenzyme A biosynthesis"], "60495": ["HS-GAG degradation"], "60496": ["Vitamin B5 (pantothenate) metabolism"], "60509": ["Carboxyterminal post-translational modifications of tubulin"], "60528": ["tRNA processing in the nucleus", "tRNA processing in the mitochondrion", "rRNA processing in the mitochondrion"], "60559": ["SRP-dependent cotranslational protein targeting to membrane", "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)", "Synthesis, secretion, and deacylation of Ghrelin"], "60560": ["Retrograde transport at the Trans-Golgi-Network"], "60561": ["COPI-dependent Golgi-to-ER retrograde traffic"], "6059": ["OAS antiviral response", "Interferon alpha/beta signaling"], "60592": ["Retrograde transport at the Trans-Golgi-Network"], "60598": ["Phase 4 - resting membrane potential"], "606495": ["Erythrocytes take up carbon dioxide and release oxygen"], "60673": ["Macroautophagy"], "60675": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "60676": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "60678": ["Selenocysteine synthesis"], "60684": ["RAB GEFs exchange GTP for GDP on RABs"], "607": ["Formation of the beta-catenin:TCF transactivating complex", "Deactivation of the beta-catenin transactivating complex"], "608": ["TNFs bind their physiological receptors"], "6091": ["Netrin-1 signaling", "Signaling by ROBO receptors", "Signaling by ROBO receptors", "Activation of RAC1", "Regulation of commissural axon pathfinding by SLIT and ROBO", "Regulation of commissural axon pathfinding by SLIT and ROBO", "Inactivation of CDC42 and RAC1", "Role of ABL in ROBO-SLIT signaling", "Role of ABL in ROBO-SLIT signaling", "SLIT2:ROBO1 increases RHOA activity", "Regulation of cortical dendrite branching", "Regulation of expression of SLITs and ROBOs", "Regulation of expression of SLITs and ROBOs"], "6092": ["Signaling by ROBO receptors", "Signaling by ROBO receptors", "Regulation of commissural axon pathfinding by SLIT and ROBO", "Regulation of cortical dendrite branching", "Regulation of expression of SLITs and ROBOs", "ROBO receptors bind AKAP5"], "6093": ["Apoptotic cleavage of cellular proteins", "EPHB-mediated forward signaling", "EPHB-mediated forward signaling", "EPHA-mediated growth cone collapse", "G alpha (12/13) signalling events", "Sema4D induced cell migration and growth-cone collapse", "Sema4D induced cell migration and growth-cone collapse", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate ROCKs", "RHO GTPases Activate ROCKs", "Neutrophil degranulation"], "6095": ["RORA activates gene expression", "RORA activates gene expression", "PPARA activates gene expression", "Nuclear Receptor transcription pathway", "Circadian Clock", "Circadian Clock", "SUMOylation of intracellular receptors", "Interleukin-4 and Interleukin-13 signaling"], "6097": ["Nuclear Receptor transcription pathway", "Interleukin-4 and Interleukin-13 signaling", "RUNX3 Regulates Immune Response and Cell Migration"], "610": ["HCN channels"], "6102": ["Trafficking of myristoylated proteins to the cilium"], "611": ["The retinoid cycle in cones (daylight vision)", "Retinoid cycle disease events", "G alpha (i) signalling events", "Opsins"], "6117": ["Translesion synthesis by REV1", "Recognition of DNA damage by PCNA-containing replication complex", "Translesion Synthesis by POLH", "Removal of the Flap Intermediate from the C-strand", "Activation of ATR in response to replication stress", "SUMOylation of DNA damage response and repair proteins", "Regulation of HSF1-mediated heat shock response", "HSF1 activation", "Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "PCNA-Dependent Long Patch Base Excision Repair", "Translesion synthesis by POLK", "Translesion synthesis by POLI", "Termination of translesion DNA synthesis", "HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Formation of Incision Complex in GG-NER", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Fanconi Anemia Pathway", "Regulation of TP53 Activity through Phosphorylation", "Activation of the pre-replicative complex", "Removal of the Flap Intermediate", "G2/M DNA damage checkpoint", "Meiotic recombination"], "6118": ["Translesion synthesis by REV1", "Recognition of DNA damage by PCNA-containing replication complex", "Translesion Synthesis by POLH", "Removal of the Flap Intermediate from the C-strand", "Activation of ATR in response to replication stress", "Regulation of HSF1-mediated heat shock response", "HSF1 activation", "Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "PCNA-Dependent Long Patch Base Excision Repair", "Translesion synthesis by POLK", "Translesion synthesis by POLI", "Termination of translesion DNA synthesis", "HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Formation of Incision Complex in GG-NER", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Fanconi Anemia Pathway", "Regulation of TP53 Activity through Phosphorylation", "Activation of the pre-replicative complex", "Removal of the Flap Intermediate", "G2/M DNA damage checkpoint", "Meiotic recombination"], "6119": ["Translesion synthesis by REV1", "Recognition of DNA damage by PCNA-containing replication complex", "Translesion Synthesis by POLH", "Removal of the Flap Intermediate from the C-strand", "Activation of ATR in response to replication stress", "Regulation of HSF1-mediated heat shock response", "HSF1 activation", "Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "PCNA-Dependent Long Patch Base Excision Repair", "Translesion synthesis by POLK", "Translesion synthesis by POLI", "Termination of translesion DNA synthesis", "HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Formation of Incision Complex in GG-NER", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Fanconi Anemia Pathway", "Regulation of TP53 Activity through Phosphorylation", "Activation of the pre-replicative complex", "Removal of the Flap Intermediate", "G2/M DNA damage checkpoint", "Meiotic recombination"], "6120": ["Pentose phosphate pathway"], "6121": ["The canonical retinoid cycle in rods (twilight vision)"], "6122": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6123": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6124": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6125": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6128": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6129": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "613": ["Signaling by cytosolic FGFR1 fusion mutants", "Rho GTPase cycle", "Signaling by FGFR1 in disease"], "6130": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6132": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "613209": ["Beta defensins", "Defensins"], "613210": ["Beta defensins", "Defensins"], "613211": ["Beta defensins", "Defensins"], "6133": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6134": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6135": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6136": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6137": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6138": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6139": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6141": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6142": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6143": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6144": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6146": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6147": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6150": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "6152": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6154": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6155": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6156": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6157": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6158": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6159": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6160": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6161": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6164": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6165": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6166": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6167": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6168": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6169": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "617": ["Mitochondrial protein import"], "6170": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6171": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6173": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6175": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6176": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6181": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6182": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "6183": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "6184": ["SRP-dependent cotranslational protein targeting to membrane", "Asparagine N-linked glycosylation"], "6185": ["SRP-dependent cotranslational protein targeting to membrane", "Asparagine N-linked glycosylation"], "6187": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "RMTs methylate histone arginines", "rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Protein methylation", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6188": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6189": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6191": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "619189": ["Serine biosynthesis"], "6192": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "619279": ["Generic Transcription Pathway"], "6193": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "619373": ["Synthesis, secretion, and deacylation of Ghrelin"], "6194": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "mTORC1-mediated signalling", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6195": ["ERK/MAPK targets", "CREB phosphorylation", "Senescence-Associated Secretory Phenotype (SASP)", "Senescence-Associated Secretory Phenotype (SASP)", "Recycling pathway of L1", "CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling", "RSK activation", "RSK activation", "Gastrin-CREB signalling pathway via PKC and MAPK"], "6196": ["ERK/MAPK targets", "CREB phosphorylation", "Senescence-Associated Secretory Phenotype (SASP)", "Senescence-Associated Secretory Phenotype (SASP)", "Recycling pathway of L1", "CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling", "RSK activation", "RSK activation", "Gastrin-CREB signalling pathway via PKC and MAPK"], "6197": ["ERK/MAPK targets", "CREB phosphorylation", "Senescence-Associated Secretory Phenotype (SASP)", "Senescence-Associated Secretory Phenotype (SASP)", "Recycling pathway of L1", "CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling", "RSK activation", "RSK activation", "Gastrin-CREB signalling pathway via PKC and MAPK"], "6198": ["mTORC1-mediated signalling"], "6199": ["AKT phosphorylates targets in the nucleus", "Constitutive Signaling by AKT1 E17K in Cancer"], "6201": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6202": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6203": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6204": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6205": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6206": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6207": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6208": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6209": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6210": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6217": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6218": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "622": ["Utilization of Ketone Bodies", "Synthesis of Ketone Bodies"], "6222": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6223": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6224": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6227": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6228": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6229": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "623": ["Peptide ligand-binding receptors", "G alpha (q) signalling events", "G alpha (i) signalling events"], "6230": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6231": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6232": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Major pathway of rRNA processing in the nucleolus and cytosol", "Mitotic Prometaphase", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6233": ["Translesion synthesis by REV1", "Recognition of DNA damage by PCNA-containing replication complex", "Translesion Synthesis by POLH", "Activation of NF-kappaB in B cells", "ISG15 antiviral mechanism", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "ER-Phagosome pathway", "Downregulation of ERBB4 signaling", "Spry regulation of FGF signaling", "Downregulation of ERBB2:ERBB3 signaling", "L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "Budding and maturation of HIV virion", "NOD1/2 Signaling Pathway", "TICAM1, RIP1-mediated IKK complex recruitment ", "DDX58/IFIH1-mediated induction of interferon-alpha/beta", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Membrane binding and targetting of GAG proteins", "Assembly Of The HIV Virion", "APC-Cdc20 mediated degradation of Nek2A", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "EGFR downregulation", "SCF(Skp2)-mediated degradation of p27/p21", "Viral mRNA Translation", "Degradation of beta-catenin by the destruction complex", "TCF dependent signaling in response to WNT", "Downstream TCR signaling", "NRIF signals cell death from the nucleus", "p75NTR recruits signalling complexes", "NF-kB is activated and signals survival", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "NOTCH1 Intracellular Domain Regulates Transcription", "Activated NOTCH1 Transmits Signal to the Nucleus", "Activated NOTCH1 Transmits Signal to the Nucleus", "Downregulation of TGF-beta receptor signaling", "Downregulation of TGF-beta receptor signaling", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Selenocysteine synthesis", "Separation of Sister Chromatids", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "Oncogene Induced Senescence", "Regulation of PLK1 Activity at G2/M Transition", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Stimuli-sensing channels", "Constitutive Signaling by NOTCH1 HD Domain Mutants", "FCERI mediated NF-kB activation", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "NOTCH2 Activation and Transmission of Signal to the Nucleus", "Regulation of innate immune responses to cytosolic DNA", "Glycogen synthesis", "Autodegradation of the E3 ubiquitin ligase COP1", "Deactivation of the beta-catenin transactivating complex", "Myoclonic epilepsy of Lafora", "ABC-family proteins mediated transport", "Circadian Clock", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "activated TAK1 mediates p38 MAPK activation", "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Regulation of FZD by ubiquitination", "Pink/Parkin Mediated Mitophagy", "N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Hedgehog 'on' state", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "Translesion synthesis by POLK", "Translesion synthesis by POLI", "Termination of translesion DNA synthesis", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "Negative regulation of MAPK pathway", "Regulation of necroptotic cell death", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAP3K8 (TPL2)-dependent MAPK1/3 activation", "HDR through Homologous Recombination (HRR)", "MAPK6/MAPK4 signaling", "UCH proteinases", "UCH proteinases", "Josephin domain DUBs", "Ub-specific processing proteases", "Ovarian tumor domain proteases", "Metalloprotease DUBs", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Processing of DNA double-strand break ends", "DNA Damage Recognition in GG-NER", "Formation of Incision Complex in GG-NER", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Fanconi Anemia Pathway", "Major pathway of rRNA processing in the nucleolus and cytosol", "Regulation of TP53 Activity through Phosphorylation", "Regulation of TP53 Degradation", "Regulation of TP53 Activity through Methylation", "Negative regulation of MET activity", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "Cyclin D associated events in G1", "G2/M Checkpoints", "Stabilization of p53", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "Downregulation of ERBB2 signaling", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "E3 ubiquitin ligases ubiquitinate target proteins", "InlB-mediated entry of Listeria monocytogenes into host cell", "InlA-mediated entry of Listeria monocytogenes into host cells", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN localization", "Regulation of PTEN stability and activity", "Neddylation", "ER Quality Control Compartment (ERQC)", "Regulation of expression of SLITs and ROBOs", "Regulation of expression of SLITs and ROBOs", "NOTCH3 Activation and Transmission of Signal to the Nucleus", "NOTCH3 Activation and Transmission of Signal to the Nucleus", "TICAM1-dependent activation of IRF3/IRF7", "TICAM1,TRAF6-dependent induction of TAK1 complex", "Interleukin-1 signaling", "Peroxisomal protein import", "Peroxisomal protein import", "Regulation of signaling by CBL", "Endosomal Sorting Complex Required For Transport (ESCRT)", "Iron uptake and transport", "Negative regulators of DDX58/IFIH1 signaling", "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon", "IRAK1 recruits IKK complex", "IKK complex recruitment mediated by RIP1", "IRAK2 mediated activation of TAK1 complex", "TRAF6-mediated induction of TAK1 complex within TLR4 complex", "Negative regulation of NOTCH4 signaling", "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "Amyloid fiber formation", "Antigen processing: Ubiquitination & Proteasome degradation"], "6234": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6235": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6237": ["SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "Sema4D mediated inhibition of cell attachment and migration"], "624": ["Peptide ligand-binding receptors", "G alpha (q) signalling events", "G alpha (i) signalling events"], "6240": ["Interconversion of nucleotide di- and triphosphates"], "6241": ["Interconversion of nucleotide di- and triphosphates", "Activation of E2F1 target genes at G1/S", "Transcriptional Regulation by E2F6"], "6242": ["RHO GTPases Activate Rhotekin and Rhophilins", "RHO GTPases Activate Rhotekin and Rhophilins"], "6248": ["Organic cation transport", "Intestinal hexose absorption"], "6249": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "6251": ["Regulation of cytoskeletal remodeling and cell spreading by IPP complex components"], "6256": ["RORA activates gene expression", "BMAL1:CLOCK,NPAS2 activates circadian gene expression", "Recycling of bile acids and salts", "Synthesis of bile acids and bile salts", "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "PPARA activates gene expression", "PPARA activates gene expression", "Import of palmitoyl-CoA into the mitochondrial matrix", "Regulation of pyruvate dehydrogenase (PDH) complex", "Endogenous sterols", "Transcriptional activation of mitochondrial biogenesis", "Activation of gene expression by SREBF (SREBP)", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation", "Nuclear Receptor transcription pathway", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)", "Circadian Clock", "SUMOylation of intracellular receptors", "Signaling by Retinoic Acid", "Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "6257": ["PPARA activates gene expression", "Nuclear Receptor transcription pathway", "Signaling by Retinoic Acid"], "6258": ["Nuclear Receptor transcription pathway", "Signaling by Retinoic Acid"], "6259": ["TCF dependent signaling in response to WNT", "PCP/CE pathway"], "6261": ["Stimuli-sensing channels", "Ion homeostasis"], "6262": ["Stimuli-sensing channels", "Ion homeostasis"], "6263": ["Stimuli-sensing channels", "Ion homeostasis"], "627": ["MECP2 regulates transcription of neuronal ligands", "BDNF activates NTRK2 (TRKB) signaling", "Activated NTRK2 signals through RAS", "Activated NTRK2 signals through PLCG1", "Activated NTRK2 signals through PLCG1", "Activated NTRK2 signals through PI3K", "Activated NTRK2 signals through FRS2 and FRS3", "Activated NTRK2 signals through FRS2 and FRS3", "Activated NTRK2 signals through FYN", "NTRK2 activates RAC1", "NTRK2 activates RAC1", "Activated NTRK2 signals through CDK5"], "6271": ["Regulation of TLR by endogenous ligand"], "6272": ["Golgi Associated Vesicle Biogenesis"], "6278": ["Neutrophil degranulation", "Metal sequestration by antimicrobial proteins"], "6279": ["RHO GTPases Activate NADPH Oxidases", "Regulation of TLR by endogenous ligand", "Neutrophil degranulation", "Metal sequestration by antimicrobial proteins"], "6280": ["RHO GTPases Activate NADPH Oxidases", "Regulation of TLR by endogenous ligand", "Neutrophil degranulation", "Metal sequestration by antimicrobial proteins"], "6281": ["Dissolution of Fibrin Clot"], "6282": ["Neutrophil degranulation"], "6283": ["TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "Neutrophil degranulation", "Advanced glycosylation endproduct receptor signaling", "Advanced glycosylation endproduct receptor signaling", "TRAF6 mediated NF-kB activation"], "6285": ["Nuclear signaling by ERBB4", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "Advanced glycosylation endproduct receptor signaling", "Advanced glycosylation endproduct receptor signaling", "TRAF6 mediated NF-kB activation"], "6286": ["Neutrophil degranulation"], "6288": ["Scavenging by Class B Receptors", "G alpha (q) signalling events", "G alpha (i) signalling events", "Formyl peptide receptors bind formyl peptides and many other ligands", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "Interleukin-4 and Interleukin-13 signaling", "Advanced glycosylation endproduct receptor signaling", "Advanced glycosylation endproduct receptor signaling", "TRAF6 mediated NF-kB activation", "Amyloid fiber formation"], "629": ["Alternative complement activation", "Activation of C3 and C5", "Regulation of Complement cascade"], "6293": ["Retrograde transport at the Trans-Golgi-Network"], "6294": ["SUMOylation of transcription cofactors"], "6295": ["Activation of the phototransduction cascade", "Inactivation, recovery and regulation of the phototransduction cascade", "Inactivation, recovery and regulation of the phototransduction cascade"], "6296": ["Beta oxidation of butanoyl-CoA to acetyl-CoA"], "6299": ["POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation"], "6300": ["NOD1/2 Signaling Pathway", "p38MAPK events", "Activation of PPARGC1A (PGC-1alpha) by phosphorylation", "CDO in myogenesis", "CDO in myogenesis", "DSCAM interactions", "VEGFA-VEGFR2 Pathway"], "6301": ["Selenocysteine synthesis", "Cytosolic tRNA aminoacylation"], "6303": ["Interconversion of polyamines"], "63036": ["Formation of the cornified envelope"], "6304": ["Apoptotic cleavage of cellular proteins", "SUMOylation of chromatin organization proteins"], "6305": ["Synthesis of PIPs at the ER membrane", "RAB GEFs exchange GTP for GDP on RABs"], "6307": ["Cholesterol biosynthesis"], "6309": ["Activation of gene expression by SREBF (SREBP)", "Cholesterol biosynthesis via desmosterol", "Cholesterol biosynthesis via lathosterol"], "6314": ["HATs acetylate histones", "Ub-specific processing proteases"], "6317": ["Neutrophil degranulation"], "6319": ["Activation of gene expression by SREBF (SREBP)", "Fatty acyl-CoA biosynthesis"], "632": ["Gamma-carboxylation of protein precursors", "Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "Removal of aminoterminal propeptides from gamma-carboxylated proteins", "RUNX2 regulates osteoblast differentiation"], "6323": ["Interaction between L1 and Ankyrins", "Phase 0 - rapid depolarisation"], "6324": ["Interaction between L1 and Ankyrins", "Phase 0 - rapid depolarisation"], "6326": ["Interaction between L1 and Ankyrins", "Phase 0 - rapid depolarisation"], "6327": ["Interaction between L1 and Ankyrins", "Phase 0 - rapid depolarisation"], "6328": ["Interaction between L1 and Ankyrins", "Phase 0 - rapid depolarisation"], "6329": ["Interaction between L1 and Ankyrins", "Phase 0 - rapid depolarisation"], "633": ["A tetrasaccharide linker sequence is required for GAG synthesis", "Chondroitin sulfate biosynthesis", "Dermatan sulfate biosynthesis", "CS/DS degradation", "ECM proteoglycans", "ECM proteoglycans", "Defective B4GALT7 causes EDS, progeroid type", "Defective B3GAT3 causes JDSSDHD", "Defective CHST3 causes SEDCJD", "Defective CHST14 causes EDS, musculocontractural type", "Defective CHSY1 causes TPBS", "Defective B3GALT6 causes EDSP2 and SEMDJL1"], "6330": ["Interaction between L1 and Ankyrins", "Phase 0 - rapid depolarisation"], "6331": ["Interaction between L1 and Ankyrins", "Phase 0 - rapid depolarisation"], "6332": ["Interaction between L1 and Ankyrins", "Phase 0 - rapid depolarisation"], "6334": ["Interaction between L1 and Ankyrins", "Phase 0 - rapid depolarisation"], "6335": ["Interaction between L1 and Ankyrins", "Phase 0 - rapid depolarisation"], "6336": ["Interaction between L1 and Ankyrins", "Phase 0 - rapid depolarisation"], "6337": ["Stimuli-sensing channels"], "6338": ["Stimuli-sensing channels"], "6339": ["Stimuli-sensing channels"], "634": ["Fibronectin matrix formation", "Cell surface interactions at the vascular wall", "Neutrophil degranulation"], "6340": ["Stimuli-sensing channels"], "6341": ["TP53 Regulates Metabolic Genes", "Respiratory electron transport"], "6342": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "alpha-linolenic acid (ALA) metabolism", "Beta-oxidation of pristanoyl-CoA", "Peroxisomal protein import", "Peroxisomal protein import", "TYSND1 cleaves peroxisomal proteins"], "6343": ["G alpha (s) signalling events", "Glucagon-type ligand receptors"], "6344": ["G alpha (s) signalling events", "Glucagon-type ligand receptors"], "6346": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "6347": ["ATF4 activates genes", "Interleukin-10 signaling", "Interleukin-4 and Interleukin-13 signaling"], "6348": ["Interleukin-10 signaling"], "6349": ["Interleukin-10 signaling"], "635": ["Sulfur amino acid metabolism", "Choline catabolism"], "6351": ["G alpha (i) signalling events", "Interleukin-10 signaling"], "6352": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events", "Interleukin-10 signaling"], "6356": ["Interleukin-4 and Interleukin-13 signaling"], "6357": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "636": ["COPI-independent Golgi-to-ER retrograde traffic"], "6360": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "6363": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events", "Interleukin-10 signaling"], "6364": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events", "Interleukin-10 signaling"], "6366": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "6367": ["Interleukin-10 signaling", "Interleukin-4 and Interleukin-13 signaling"], "6368": ["G alpha (q) signalling events", "G alpha (i) signalling events", "Formyl peptide receptors bind formyl peptides and many other ligands"], "637": ["Activation of BAD and translocation to mitochondria ", "Activation and oligomerization of BAK protein", "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "Activation, translocation and oligomerization of BAX", "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "Activation, myristolyation of BID and translocation to mitochondria"], "6370": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "6372": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "6373": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "6374": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "6375": ["Chemokine receptors bind chemokines", "G alpha (q) signalling events"], "6376": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "6382": ["A tetrasaccharide linker sequence is required for GAG synthesis", "HS-GAG biosynthesis", "HS-GAG biosynthesis", "HS-GAG degradation", "Cell surface interactions at the vascular wall", "Syndecan interactions", "Syndecan interactions", "Defective B4GALT7 causes EDS, progeroid type", "Defective B3GAT3 causes JDSSDHD", "Defective EXT2 causes exostoses 2", "Defective EXT1 causes exostoses 1, TRPS2 and CHDS", "Defective B3GALT6 causes EDSP2 and SEMDJL1", "Other interleukin signaling", "Retinoid metabolism and transport"], "63826": ["Serine biosynthesis"], "63827": ["Degradation of the extracellular matrix", "A tetrasaccharide linker sequence is required for GAG synthesis", "Chondroitin sulfate biosynthesis", "Dermatan sulfate biosynthesis", "CS/DS degradation", "ECM proteoglycans", "Defective B4GALT7 causes EDS, progeroid type", "Defective B3GAT3 causes JDSSDHD", "Defective CHST3 causes SEDCJD", "Defective CHST14 causes EDS, musculocontractural type", "Defective CHSY1 causes TPBS", "Defective B3GALT6 causes EDSP2 and SEMDJL1"], "6383": ["A tetrasaccharide linker sequence is required for GAG synthesis", "HS-GAG biosynthesis", "HS-GAG biosynthesis", "HS-GAG degradation", "Cell surface interactions at the vascular wall", "Syndecan interactions", "Syndecan interactions", "Defective B4GALT7 causes EDS, progeroid type", "Defective B3GAT3 causes JDSSDHD", "Defective EXT2 causes exostoses 2", "Defective EXT1 causes exostoses 1, TRPS2 and CHDS", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "EPHB-mediated forward signaling", "Defective B3GALT6 causes EDSP2 and SEMDJL1", "Post-translational protein phosphorylation", "Retinoid metabolism and transport"], "6385": ["A tetrasaccharide linker sequence is required for GAG synthesis", "HS-GAG biosynthesis", "HS-GAG biosynthesis", "HS-GAG degradation", "Cell surface interactions at the vascular wall", "Syndecan interactions", "Syndecan interactions", "Defective B4GALT7 causes EDS, progeroid type", "Defective B3GAT3 causes JDSSDHD", "Defective EXT2 causes exostoses 2", "Defective EXT1 causes exostoses 1, TRPS2 and CHDS", "Defective B3GALT6 causes EDSP2 and SEMDJL1", "Retinoid metabolism and transport"], "6386": ["Ephrin signaling", "Neurofascin interactions", "Neutrophil degranulation"], "6387": ["Nuclear signaling by ERBB4", "Signaling by ROBO receptors", "Chemokine receptors bind chemokines", "G alpha (i) signalling events", "Estrogen-dependent gene expression"], "63874": ["Acyl chain remodelling of PE"], "63875": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "6389": ["Respiratory electron transport", "Citric acid cycle (TCA cycle)"], "63891": ["Ub-specific processing proteases", "Antigen processing: Ubiquitination & Proteasome degradation"], "63892": ["tRNA modification in the nucleus and cytosol"], "63893": ["Antigen processing: Ubiquitination & Proteasome degradation"], "639": ["Regulation of TP53 Expression"], "6390": ["Respiratory electron transport", "Citric acid cycle (TCA cycle)"], "63908": ["COPII-mediated vesicle transport", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network"], "6391": ["Respiratory electron transport", "Citric acid cycle (TCA cycle)"], "63916": ["Regulation of actin dynamics for phagocytic cup formation", "VEGFA-VEGFR2 Pathway", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases"], "63917": ["O-linked glycosylation of mucins"], "6392": ["Respiratory electron transport", "Citric acid cycle (TCA cycle)"], "63923": ["ECM proteoglycans"], "63924": ["Assembly of active LPL and LIPC lipase complexes", "Lipid particle organization"], "63925": ["Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "63931": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "63934": ["Generic Transcription Pathway"], "63940": ["G alpha (i) signalling events"], "63943": ["The role of GTSE1 in G2/M progression after G2 checkpoint"], "6396": ["ISG15 antiviral mechanism", "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "COPII-mediated vesicle transport", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "RHO GTPases Activate Formins", "tRNA processing in the nucleus", "Mitotic Prometaphase", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "63967": ["Apoptotic cleavage of cellular proteins", "Activation of ATR in response to replication stress", "Ub-specific processing proteases", "Processing of DNA double-strand break ends"], "63970": ["TP53 Regulates Transcription of Genes Involved in Cytochrome C Release"], "63971": ["Association of TriC/CCT with target proteins during biosynthesis"], "63976": ["PKMTs methylate histone lysines"], "63978": ["Transcriptional regulation of pluripotent stem cells"], "63982": ["Stimuli-sensing channels"], "6399": ["COPII-mediated vesicle transport", "RAB GEFs exchange GTP for GDP on RABs"], "640": ["RUNX1 regulates transcription of genes involved in BCR signaling", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "6400": ["Pre-NOTCH Processing in Golgi", "ABC-family proteins mediated transport", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Defective CFTR causes cystic fibrosis", "ER Quality Control Compartment (ERQC)"], "6401": ["Cell surface interactions at the vascular wall"], "6402": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "Neutrophil degranulation"], "6403": ["Platelet degranulation ", "Cell surface interactions at the vascular wall"], "6404": ["Cell surface interactions at the vascular wall"], "6406": ["Antimicrobial peptides", "Amyloid fiber formation"], "64061": ["XBP1(S) activates chaperone genes"], "64064": ["Utilization of Ketone Bodies"], "64065": ["TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "Formation of the cornified envelope"], "64077": ["Purine ribonucleoside monophosphate biosynthesis"], "64078": ["Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"], "64080": ["Pentose phosphate pathway"], "64087": ["Biotin transport and metabolism", "Defective HLCS causes multiple carboxylase deficiency", "Branched-chain amino acid catabolism"], "64096": ["NCAM1 interactions", "RAF/MAP kinase cascade", "RET signaling"], "641": ["SUMOylation of DNA damage response and repair proteins", "HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Regulation of TP53 Activity through Phosphorylation", "G2/M DNA damage checkpoint", "Meiotic recombination"], "64105": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Deposition of new CENPA-containing nucleosomes at the centromere", "Mitotic Prometaphase"], "64106": ["Orexin and neuropeptides FF and QRFP bind to their respective receptors", "G alpha (q) signalling events"], "64108": ["Olfactory Signaling Pathway"], "64109": ["Interleukin-7 signaling", "Interleukin-7 signaling"], "64114": ["Neutrophil degranulation"], "64116": ["Zinc influx into cells by the SLC39 gene family"], "64121": ["Macroautophagy", "mTOR signalling", "mTORC1-mediated signalling", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Regulation of PTEN gene transcription"], "64122": ["Gamma carboxylation, hypusine formation and arylsulfatase activation"], "64127": ["NOD1/2 Signaling Pathway", "NOD1/2 Signaling Pathway", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "activated TAK1 mediates p38 MAPK activation", "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "Ovarian tumor domain proteases", "Interleukin-1 signaling"], "64130": ["Dopamine Neurotransmitter Release Cycle", "RHO GTPases Activate Rhotekin and Rhophilins", "Neurexins and neuroligins"], "64131": ["A tetrasaccharide linker sequence is required for GAG synthesis"], "64132": ["A tetrasaccharide linker sequence is required for GAG synthesis"], "64135": ["DDX58/IFIH1-mediated induction of interferon-alpha/beta", "Ub-specific processing proteases", "Ovarian tumor domain proteases", "TRAF3-dependent IRF activation pathway", "TRAF6 mediated IRF7 activation", "TRAF6 mediated NF-kB activation", "TRAF6 mediated NF-kB activation", "NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10", "Negative regulators of DDX58/IFIH1 signaling", "Negative regulators of DDX58/IFIH1 signaling"], "64137": ["ABC transporters in lipid homeostasis"], "641371": ["Mitochondrial Fatty Acid Beta-Oxidation"], "641372": ["Beta-oxidation of very long chain fatty acids"], "6414": ["Platelet degranulation "], "64145": ["Toll Like Receptor 9 (TLR9) Cascade", "Factors involved in megakaryocyte development and platelet production"], "64147": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins", "Kinesins"], "64151": ["Condensation of Prometaphase Chromosomes", "Condensation of Prometaphase Chromosomes"], "6416": ["Oxidative Stress Induced Senescence", "Oxidative Stress Induced Senescence", "FCERI mediated MAPK activation", "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "Uptake and function of anthrax toxins", "MAP3K8 (TPL2)-dependent MAPK1/3 activation"], "64167": ["Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "64170": ["NOD1/2 Signaling Pathway", "CLEC7A (Dectin-1) signaling"], "64174": ["Synthesis of Leukotrienes (LT) and Eoxins (EX)", "Aflatoxin activation and detoxification"], "64175": ["Collagen biosynthesis and modifying enzymes"], "6418": ["Condensation of Prophase Chromosomes", "HuR (ELAVL1) binds and stabilizes mRNA"], "64180": ["Synthesis of Leukotrienes (LT) and Eoxins (EX)", "Aflatoxin activation and detoxification"], "642": ["Antigen processing: Ubiquitination & Proteasome degradation"], "6421": ["PTK6 Regulates Proteins Involved in RNA Processing"], "64210": ["Cytosolic iron-sulfur cluster assembly"], "64216": ["Mitochondrial transcription initiation", "Transcriptional activation of mitochondrial biogenesis"], "64218": ["Other semaphorin interactions"], "64219": ["Antigen processing: Ubiquitination & Proteasome degradation"], "6422": ["TCF dependent signaling in response to WNT", "Negative regulation of TCF-dependent signaling by WNT ligand antagonists"], "64220": ["Retinoid cycle disease events", "The canonical retinoid cycle in rods (twilight vision)"], "64221": ["Regulation of commissural axon pathfinding by SLIT and ROBO", "Regulation of commissural axon pathfinding by SLIT and ROBO", "Regulation of expression of SLITs and ROBOs", "ROBO receptors bind AKAP5"], "64223": ["PIP3 activates AKT signaling", "Macroautophagy", "mTOR signalling", "mTORC1-mediated signalling", "HSF1-dependent transactivation", "Energy dependent regulation of mTOR by LKB1-AMPK", "CD28 dependent PI3K/Akt signaling", "VEGFR2 mediated vascular permeability", "TP53 Regulates Metabolic Genes", "Constitutive Signaling by AKT1 E17K in Cancer", "Regulation of TP53 Degradation", "Regulation of PTEN gene transcription"], "6423": ["TCF dependent signaling in response to WNT", "Negative regulation of TCF-dependent signaling by WNT ligand antagonists"], "64240": ["ABC transporters in lipid homeostasis", "Defective ABCG8 causes gallbladder disease 4 and sitosterolemia", "Defective ABCG5 causes sitosterolemia"], "64241": ["ABC transporters in lipid homeostasis", "Defective ABCG8 causes gallbladder disease 4 and sitosterolemia", "Defective ABCG5 causes sitosterolemia"], "6426": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "mRNA 3'-end processing"], "6427": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "mRNA 3'-end processing"], "6428": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing"], "64283": ["EPHB-mediated forward signaling"], "64284": ["RAB geranylgeranylation"], "6429": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing"], "643": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "6430": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing"], "6431": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "mRNA 3'-end processing"], "6432": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "mRNA 3'-end processing"], "64320": ["Antigen processing: Ubiquitination & Proteasome degradation"], "64321": ["Deactivation of the beta-catenin transactivating complex"], "64324": ["PKMTs methylate histone lysines"], "64326": ["Autodegradation of the E3 ubiquitin ligase COP1", "Neddylation"], "64333": ["Rho GTPase cycle", "Neutrophil degranulation"], "643394": ["Formation of the cornified envelope"], "6434": ["mRNA Splicing - Major Pathway"], "643414": ["Formation of the cornified envelope"], "643418": ["Formation of the cornified envelope"], "64344": ["Regulation of gene expression by Hypoxia-inducible Factor", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Transcriptional regulation of pluripotent stem cells", "Neddylation"], "64377": ["Reactions specific to the complex N-glycan synthesis pathway"], "643803": ["Keratinization"], "643812": ["Keratinization"], "643834": ["Surfactant metabolism"], "643847": ["Surfactant metabolism"], "64386": ["Activation of Matrix Metalloproteinases", "Neutrophil degranulation"], "64388": ["Signaling by BMP"], "6439": ["Surfactant metabolism", "Defective pro-SFTPB causes pulmonary surfactant metabolism dysfunction 1 (SMDP1) and respiratory distress syndrome (RDS)", "Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5)", "Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)"], "64398": ["Tight junction interactions"], "64399": ["Ligand-receptor interactions"], "644": ["Heme degradation"], "6440": ["Surfactant metabolism", "Defective pro-SFTPC causes pulmonary surfactant metabolism dysfunction 2 (SMDP2) and respiratory distress syndrome (RDS)", "Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5)", "Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)"], "64403": ["Adherens junctions interactions"], "64407": ["G alpha (q) signalling events", "G alpha (i) signalling events", "G alpha (i) signalling events"], "64409": ["O-linked glycosylation of mucins"], "6441": ["Toll Like Receptor 4 (TLR4) Cascade", "Toll Like Receptor TLR1:TLR2 Cascade", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Signal regulatory protein family interactions", "Surfactant metabolism", "Regulation of TLR by endogenous ligand", "Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5)", "Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)"], "64410": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "64411": ["Rho GTPase cycle"], "644150": ["Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs"], "644186": ["Meiotic synapsis"], "64419": ["Macroautophagy", "Synthesis of PIPs at the plasma membrane"], "64421": ["Nonhomologous End-Joining (NHEJ)"], "64422": ["Macroautophagy"], "64425": ["NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase I Transcription Termination"], "64426": ["HDACs deacetylate histones", "NoRC negatively regulates rRNA expression", "Ub-specific processing proteases"], "64428": ["Cytosolic iron-sulfur cluster assembly"], "64432": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "644414": ["Beta defensins", "Defensins"], "6446": ["Stimuli-sensing channels", "Regulation of TP53 Degradation", "Transcriptional Regulation by MECP2"], "6448": ["HS-GAG degradation", "MPS IIIA - Sanfilippo syndrome A"], "645": ["Heme degradation"], "6453": ["NRAGE signals death through JNK", "Rho GTPase cycle", "EPHB-mediated forward signaling", "EPHB-mediated forward signaling", "G alpha (12/13) signalling events", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "645402": ["Ub-specific processing proteases"], "6455": ["EGFR downregulation", "Negative regulation of MET activity", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "InlB-mediated entry of Listeria monocytogenes into host cell"], "6456": ["Retrograde neurotrophin signalling", "Retrograde neurotrophin signalling", "EGFR downregulation", "MHC class II antigen presentation", "Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis", "Recycling pathway of L1", "Recycling pathway of L1", "Negative regulation of MET activity", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "InlB-mediated entry of Listeria monocytogenes into host cell"], "6457": ["EGFR downregulation", "Negative regulation of MET activity", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "InlB-mediated entry of Listeria monocytogenes into host cell"], "64577": ["RA biosynthesis pathway"], "64579": ["HS-GAG biosynthesis"], "64581": ["CLEC7A (Dectin-1) signaling", "CLEC7A (Dectin-1) signaling"], "645836": ["Ub-specific processing proteases"], "64600": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PS", "Acyl chain remodelling of PE", "Acyl chain remodelling of PI", "Acyl chain remodelling of PG", "Synthesis of PA"], "6461": ["VEGFA-VEGFR2 Pathway", "VEGFA-VEGFR2 Pathway"], "6464": ["Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "SHC1 events in ERBB2 signaling", "SHC1 events in ERBB2 signaling", "SHC1 events in ERBB4 signaling", "Signalling to RAS", "Signalling to RAS", "SHC1 events in EGFR signaling", "Tie2 Signaling", "DAP12 signaling", "SHC-related events triggered by IGF1R", "SHC-related events triggered by IGF1R", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "Integrin alphaIIb beta3 signaling", "XBP1(S) activates chaperone genes", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "Constitutive Signaling by EGFRvIII", "SHC-mediated cascade:FGFR1", "SHC-mediated cascade:FGFR2", "SHC-mediated cascade:FGFR3", "SHC-mediated cascade:FGFR4", "RAF/MAP kinase cascade", "Signal attenuation", "Insulin receptor signalling cascade", "Insulin receptor signalling cascade", "MET activates RAS signaling", "RET signaling", "Interleukin-15 signaling", "Interleukin-15 signaling", "Interleukin-2 signaling", "Activated NTRK2 signals through RAS", "Erythropoietin activates RAS", "Erythropoietin activates RAS", "Activated NTRK3 signals through RAS", "Interleukin receptor SHC signaling"], "646480": ["Triglyceride catabolism"], "646486": ["Triglyceride catabolism"], "646627": ["Post-translational modification: synthesis of GPI-anchored proteins"], "6468": ["Association of TriC/CCT with target proteins during biosynthesis", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "64682": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6", "Antigen processing: Ubiquitination & Proteasome degradation"], "64689": ["Golgi Cisternae Pericentriolar Stack Reorganization", "Golgi Cisternae Pericentriolar Stack Reorganization", "COPII-mediated vesicle transport", "COPI-mediated anterograde transport"], "6469": ["Class B/2 (Secretin family receptors)", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Release of Hh-Np from the secreting cell", "Release of Hh-Np from the secreting cell", "Ligand-receptor interactions", "Ligand-receptor interactions", "Hedgehog 'on' state", "Activation of SMO", "HHAT G278V abrogates palmitoylation of Hh-Np"], "6470": ["Metabolism of folate and pterines", "Carnitine synthesis"], "64708": ["DNA Damage Recognition in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Cargo recognition for clathrin-mediated endocytosis", "Neddylation"], "64711": ["HS-GAG biosynthesis"], "64718": ["Antigen processing: Ubiquitination & Proteasome degradation"], "6472": ["Metabolism of folate and pterines"], "64746": ["Golgi Associated Vesicle Biogenesis"], "64748": ["Lysosphingolipid and LPA receptors"], "64750": ["Signaling by BMP", "Downregulation of TGF-beta receptor signaling", "Downregulation of TGF-beta receptor signaling", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Hedgehog 'on' state", "Hedgehog 'on' state", "Ub-specific processing proteases", "Regulation of RUNX3 expression and activity", "Antigen processing: Ubiquitination & Proteasome degradation"], "64754": ["PKMTs methylate histone lysines"], "64757": ["Phase I - Functionalization of compounds"], "64759": ["MET interacts with TNS proteins"], "6476": ["Digestion of dietary carbohydrate", "Intestinal saccharidase deficiencies", "Intestinal saccharidase deficiencies"], "64764": ["CREB3 factors activate genes"], "64768": ["Synthesis of pyrophosphates in the cytosol", "Synthesis of IPs in the nucleus"], "64769": ["HATs acetylate histones", "HATs acetylate histones", "Regulation of TP53 Activity through Acetylation"], "6477": ["Netrin-1 signaling", "Amyloid fiber formation", "Antigen processing: Ubiquitination & Proteasome degradation"], "64772": ["N-glycan trimming in the ER and Calnexin/Calreticulin cycle"], "6478": ["Netrin-1 signaling", "Ub-specific processing proteases", "Amyloid fiber formation", "Antigen processing: Ubiquitination & Proteasome degradation"], "64780": ["Factors involved in megakaryocyte development and platelet production"], "64781": ["Glycosphingolipid metabolism"], "64784": ["Transcriptional activation of mitochondrial biogenesis", "Circadian Clock"], "64785": ["Unwinding of DNA", "Unwinding of DNA"], "64786": ["TBC/RABGAPs"], "64788": ["Assembly of active LPL and LIPC lipase complexes"], "64792": ["Intraflagellar transport", "Intraflagellar transport"], "648": ["Oxidative Stress Induced Senescence", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of transcription cofactors", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA methylation proteins", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription", "Transcriptional Regulation by E2F6"], "6480": ["Sialic acid metabolism", "N-Glycan antennae elongation", "Termination of O-glycan biosynthesis"], "64801": ["Cholesterol biosynthesis"], "64802": ["Nicotinate metabolism"], "64805": ["ADP signalling through P2Y purinoceptor 12", "P2Y receptors", "G alpha (i) signalling events"], "64806": ["Interleukin-17 signaling"], "64816": ["Miscellaneous substrates", "Xenobiotics"], "6482": ["Keratan sulfate biosynthesis", "Sialic acid metabolism", "Termination of O-glycan biosynthesis"], "6483": ["Keratan sulfate biosynthesis", "Sialic acid metabolism", "Termination of O-glycan biosynthesis"], "64834": ["Linoleic acid (LA) metabolism", "alpha-linolenic acid (ALA) metabolism", "Synthesis of very long-chain fatty acyl-CoAs", "Synthesis of very long-chain fatty acyl-CoAs"], "64837": ["MHC class II antigen presentation", "RHO GTPases activate KTN1", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "6484": ["Pre-NOTCH Processing in Golgi", "Keratan sulfate biosynthesis", "Sialic acid metabolism", "N-Glycan antennae elongation", "Termination of O-glycan biosynthesis"], "64840": ["WNT ligand biogenesis and trafficking", "WNT ligand secretion is abrogated by the PORCN inhibitor LGK974"], "64841": ["Synthesis of UDP-N-acetyl-glucosamine"], "64849": ["Sodium-coupled sulphate, di- and tri-carboxylate transporters"], "64850": ["Synthesis of PE"], "64856": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "64857": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "64858": ["Fanconi Anemia Pathway"], "64859": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes"], "6487": ["Pre-NOTCH Processing in Golgi", "Keratan sulfate biosynthesis", "Defective ST3GAL3 causes MCT12 and EIEE15", "Sialic acid metabolism", "Termination of O-glycan biosynthesis"], "6489": ["Sialic acid metabolism"], "649": ["Degradation of the extracellular matrix", "Degradation of the extracellular matrix", "Collagen biosynthesis and modifying enzymes", "Anchoring fibril formation", "Crosslinking of collagen fibrils", "HDL assembly"], "64900": ["Synthesis of PC", "Synthesis of PE", "Depolymerisation of the Nuclear Lamina", "Triglyceride biosynthesis"], "64902": ["Glyoxylate metabolism and glycine degradation", "Pyrimidine catabolism"], "64924": ["Insulin processing", "Zinc efflux and compartmentalization by the SLC30 family"], "64926": ["Regulation of RAS by GAPs", "Signaling by RAS mutants"], "64928": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "6494": ["Rap1 signalling"], "64946": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Deposition of new CENPA-containing nucleosomes at the centromere", "Mitotic Prometaphase"], "64949": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "64951": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "64960": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "64963": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "64965": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "64968": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "64969": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "6497": ["Signaling by BMP", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "Downregulation of SMAD2/3:SMAD4 transcriptional activity"], "64975": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "64976": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "64978": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "64979": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "6498": ["Downregulation of SMAD2/3:SMAD4 transcriptional activity", "Downregulation of SMAD2/3:SMAD4 transcriptional activity"], "64981": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "64983": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "6499": ["Association of TriC/CCT with target proteins during biosynthesis", "mRNA decay by 3' to 5' exoribonuclease"], "650": ["Signaling by BMP", "Molecules associated with elastic fibres", "Transcriptional regulation by RUNX2", "Regulation of RUNX2 expression and activity"], "6500": ["Activation of NF-kappaB in B cells", "Prolactin receptor signaling", "SCF-beta-TrCP mediated degradation of Emi1", "Vpu mediated degradation of CD4", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "NOTCH1 Intracellular Domain Regulates Transcription", "Regulation of PLK1 Activity at G2/M Transition", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling", "FCERI mediated NF-kB activation", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "Circadian Clock", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "NIK-->noncanonical NF-kB signaling", "MAP3K8 (TPL2)-dependent MAPK1/3 activation", "Orc1 removal from chromatin", "Cyclin D associated events in G1", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Neddylation", "Interleukin-1 signaling", "Iron uptake and transport", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "65003": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "65005": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "65008": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "65010": ["Multifunctional anion exchangers"], "65018": ["Pink/Parkin Mediated Mitophagy", "FOXO-mediated transcription of cell death genes"], "6502": ["APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "SCF(Skp2)-mediated degradation of p27/p21", "Ub-specific processing proteases", "Orc1 removal from chromatin", "Cyclin D associated events in G1", "Regulation of RUNX2 expression and activity", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "6505": ["Glutamate Neurotransmitter Release Cycle", "Transport of inorganic cations/anions and amino acids/oligopeptides", "Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA)"], "65055": ["Olfactory Signaling Pathway"], "65057": ["Meiotic synapsis", "Packaging Of Telomere Ends", "DNA Damage/Telomere Stress Induced Senescence"], "6506": ["Astrocytic Glutamate-Glutamine Uptake And Metabolism", "Glutamate Neurotransmitter Release Cycle", "Transport of inorganic cations/anions and amino acids/oligopeptides"], "6507": ["Astrocytic Glutamate-Glutamine Uptake And Metabolism", "Glutamate Neurotransmitter Release Cycle", "Transport of inorganic cations/anions and amino acids/oligopeptides", "Defective SLC1A3 causes episodic ataxia 6 (EA6)"], "65078": ["Axonal growth inhibition (RHOA activation)"], "6508": ["Bicarbonate transporters"], "65080": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "65083": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "6509": ["Amino acid transport across the plasma membrane"], "6510": ["Amino acid transport across the plasma membrane"], "65109": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6511": ["Glutamate Neurotransmitter Release Cycle", "Transport of inorganic cations/anions and amino acids/oligopeptides"], "65110": ["Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "6512": ["Glutamate Neurotransmitter Release Cycle", "Transport of inorganic cations/anions and amino acids/oligopeptides"], "65123": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes"], "65125": ["Stimuli-sensing channels"], "6513": ["Cellular hexose transport", "Vitamin C (ascorbate) metabolism", "Regulation of insulin secretion", "Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1)", "Lactose synthesis"], "6514": ["Cellular hexose transport", "Regulation of gene expression in beta cells", "Regulation of insulin secretion", "Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS)", "Intestinal hexose absorption"], "6515": ["Cellular hexose transport", "Vitamin C (ascorbate) metabolism", "Neutrophil degranulation", "MECP2 regulates neuronal receptors and channels"], "6517": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Cellular hexose transport", "Transcriptional regulation of white adipocyte differentiation"], "6518": ["Neutrophil degranulation", "Intestinal hexose absorption"], "6519": ["Amino acid transport across the plasma membrane", "Defective SLC3A1 causes cystinuria (CSNU)"], "652": ["Molecules associated with elastic fibres", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "6520": ["Basigin interactions", "Amino acid transport across the plasma membrane", "Tryptophan catabolism"], "6521": ["Erythrocytes take up carbon dioxide and release oxygen", "Erythrocytes take up oxygen and release carbon dioxide", "Bicarbonate transporters", "Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)"], "6522": ["Bicarbonate transporters"], "65220": ["Nicotinate metabolism"], "6523": ["Cellular hexose transport", "Defective SLC5A1 causes congenital glucose/galactose malabsorption (GGM)", "Intestinal hexose absorption"], "6524": ["Cellular hexose transport", "Defective SLC5A2 causes renal glucosuria (GLYS1)"], "65243": ["Generic Transcription Pathway"], "65251": ["Generic Transcription Pathway"], "65263": ["Amino acid synthesis and interconversion (transamination)"], "65264": ["Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Antigen processing: Ubiquitination & Proteasome degradation"], "65266": ["Stimuli-sensing channels"], "65267": ["Stimuli-sensing channels"], "65268": ["Stimuli-sensing channels"], "6527": ["Cellular hexose transport"], "6528": ["Thyroxine biosynthesis", "Organic anion transporters", "Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1)"], "6529": ["Na+/Cl- dependent neurotransmitter transporters", "Reuptake of GABA"], "6530": ["Na+/Cl- dependent neurotransmitter transporters", "Defective SLC6A2 causes orthostatic intolerance (OI)"], "6531": ["Dopamine clearance from the synaptic cleft", "Na+/Cl- dependent neurotransmitter transporters", "Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)", "Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)"], "6532": ["Serotonin clearance from the synaptic cleft"], "653240": ["Keratinization"], "6533": ["Amino acid transport across the plasma membrane", "Na+/Cl- dependent neurotransmitter transporters"], "653361": ["ROS, RNS production in phagocytes", "Cross-presentation of particulate exogenous antigens (phagosomes)", "Detoxification of Reactive Oxygen Species", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate NADPH Oxidases"], "6534": ["Na+/Cl- dependent neurotransmitter transporters", "Creatine metabolism"], "6535": ["Creatine metabolism"], "653509": ["Toll Like Receptor 4 (TLR4) Cascade", "Toll Like Receptor TLR1:TLR2 Cascade", "Signal regulatory protein family interactions", "Surfactant metabolism", "Regulation of TLR by endogenous ligand", "Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5)", "Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)"], "6536": ["Na+/Cl- dependent neurotransmitter transporters"], "653604": ["Interleukin-7 signaling", "Interleukin-7 signaling", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "HDACs deacetylate histones", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "Chromatin modifying enzymes", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation", "Factors involved in megakaryocyte development and platelet production"], "653689": ["Glutathione conjugation"], "653784": ["Recruitment of mitotic centrosome proteins and complexes", "Recruitment of NuMA to mitotic centrosomes"], "6538": ["Na+/Cl- dependent neurotransmitter transporters", "Creatine metabolism", "Reuptake of GABA"], "6539": ["Amino acid transport across the plasma membrane", "Na+/Cl- dependent neurotransmitter transporters", "Creatine metabolism", "Reuptake of GABA"], "6540": ["Na+/Cl- dependent neurotransmitter transporters", "Reuptake of GABA"], "6541": ["Amino acid transport across the plasma membrane"], "6542": ["Amino acid transport across the plasma membrane"], "654254": ["Generic Transcription Pathway"], "6543": ["Reduction of cytosolic Ca++ levels", "Sodium/Calcium exchangers", "Ion homeostasis"], "654364": ["Interconversion of nucleotide di- and triphosphates", "Neutrophil degranulation"], "654483": ["Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "6546": ["Reduction of cytosolic Ca++ levels", "Sodium/Calcium exchangers", "Ion homeostasis"], "6547": ["Reduction of cytosolic Ca++ levels", "Sodium/Calcium exchangers", "Ion homeostasis", "Mitochondrial calcium ion transport"], "6548": ["Hyaluronan uptake and degradation", "Sodium/Proton exchangers"], "6549": ["Sodium/Proton exchangers"], "655": ["Molecules associated with elastic fibres"], "6550": ["Sodium/Proton exchangers"], "6553": ["Sodium/Proton exchangers"], "6554": ["Recycling of bile acids and salts"], "6555": ["Recycling of bile acids and salts"], "6556": ["ROS, RNS production in phagocytes", "Metal ion SLC transporters", "Neutrophil degranulation", "Ion influx/efflux at host-pathogen interface"], "6557": ["Cation-coupled Chloride cotransporters", "Defective SLC12A1 causes Bartter syndrome 1 (BS1)"], "6558": ["Cation-coupled Chloride cotransporters"], "6559": ["Cation-coupled Chloride cotransporters", "Defective SLC12A3 causes Gitelman syndrome (GS)"], "6560": ["Cation-coupled Chloride cotransporters"], "6561": ["Sodium-coupled sulphate, di- and tri-carboxylate transporters"], "6563": ["Transport of bile salts and organic acids, metal ions and amine compounds"], "6564": ["Proton/oligopeptide cotransporters"], "6565": ["Proton/oligopeptide cotransporters"], "6566": ["Basigin interactions", "Proton-coupled monocarboxylate transport", "Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)", "Pyruvate metabolism"], "6567": ["Transport of organic anions"], "6568": ["Organic anion transporters"], "6569": ["Type II Na+/Pi cotransporters", "Defective SLC34A1 causes hypophosphatemic nephrolithiasis/osteoporosis 1 (NPHLOP1)", "Surfactant metabolism"], "657": ["Signaling by BMP"], "6570": ["Na+/Cl- dependent neurotransmitter transporters"], "6571": ["Serotonin Neurotransmitter Release Cycle", "Norepinephrine Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle", "Na+/Cl- dependent neurotransmitter transporters"], "6572": ["Acetylcholine Neurotransmitter Release Cycle", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "6573": ["Metabolism of folate and pterines"], "6574": ["Sodium-coupled phosphate cotransporters"], "6575": ["Sodium-coupled phosphate cotransporters", "Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1)"], "6576": ["Gluconeogenesis", "Fatty acyl-CoA biosynthesis"], "6578": ["Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2)", "Transport of organic anions"], "6579": ["Recycling of bile acids and salts", "Transport of organic anions"], "658": ["Signaling by BMP"], "6580": ["Neurotransmitter clearance", "Norepinephrine Neurotransmitter Release Cycle", "Abacavir transmembrane transport", "Na+/Cl- dependent neurotransmitter transporters", "Organic cation transport"], "6581": ["Abacavir transmembrane transport", "Organic cation transport"], "6582": ["Neurotransmitter clearance", "Norepinephrine Neurotransmitter Release Cycle", "Abacavir transmembrane transport", "Na+/Cl- dependent neurotransmitter transporters", "Organic cation transport"], "6583": ["Organic cation transport"], "6584": ["Import of palmitoyl-CoA into the mitochondrial matrix", "Organic cation transport", "Defective SLC22A5 causes systemic primary carnitine deficiency (CDSP)"], "6585": ["Netrin-1 signaling", "Signaling by ROBO receptors", "Regulation of commissural axon pathfinding by SLIT and ROBO", "Regulation of cortical dendrite branching", "Regulation of expression of SLITs and ROBOs"], "6586": ["Netrin-1 signaling", "Signaling by ROBO receptors", "Signaling by ROBO receptors", "Regulation of commissural axon pathfinding by SLIT and ROBO"], "6588": ["Ion homeostasis", "Ion transport by P-type ATPases"], "659": ["Signaling by BMP"], "6590": ["Neutrophil degranulation"], "6591": ["Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription"], "6595": ["RMTs methylate histone arginines", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "6596": ["E3 ubiquitin ligases ubiquitinate target proteins"], "6597": ["Interleukin-7 signaling", "Formation of the beta-catenin:TCF transactivating complex", "RMTs methylate histone arginines", "Chromatin modifying enzymes", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "65977": ["Synthesis of PIPs at the plasma membrane"], "6598": ["RMTs methylate histone arginines", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "65985": ["Synthesis of Ketone Bodies"], "65988": ["Generic Transcription Pathway"], "6599": ["RMTs methylate histone arginines", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "65993": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "660": ["Apoptotic cleavage of cellular proteins", "Synthesis of PIPs at the plasma membrane"], "66002": ["Fatty acids", "Eicosanoids"], "66005": ["Platelet degranulation "], "6601": ["RMTs methylate histone arginines", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "6602": ["RMTs methylate histone arginines", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "6603": ["RMTs methylate histone arginines", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "66035": ["Cellular hexose transport"], "66036": ["Synthesis of PIPs at the plasma membrane", "Synthesis of PIPs at the late endosome membrane", "Synthesis of IP2, IP, and Ins in the cytosol"], "6604": ["RORA activates gene expression", "BMAL1:CLOCK,NPAS2 activates circadian gene expression", "PPARA activates gene expression", "PPARA activates gene expression", "Transcriptional activation of mitochondrial biogenesis", "Activation of gene expression by SREBF (SREBP)", "RMTs methylate histone arginines", "Transcriptional regulation of white adipocyte differentiation", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)", "Circadian Clock", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "6605": ["RMTs methylate histone arginines", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "6606": ["snRNP Assembly"], "6607": ["snRNP Assembly"], "6608": ["Class B/2 (Secretin family receptors)", "Hedgehog 'off' state", "BBSome-mediated cargo-targeting to cilium", "Hedgehog 'on' state", "Activation of SMO", "Activation of SMO"], "6609": ["Glycosphingolipid metabolism"], "661": ["Cytosolic sensors of pathogen-associated DNA ", "RNA Polymerase III Chain Elongation", "RNA Polymerase III Transcription Termination", "RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "6610": ["Glycosphingolipid metabolism", "Ceramide signalling", "TNFR1-mediated ceramide production"], "6611": ["Metabolism of polyamines"], "6612": ["SUMO is conjugated to E1 (UBA2:SAE1)", "SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "SUMO is proteolytically processed", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of transcription factors", "SUMOylation of transcription cofactors", "SUMOylation of intracellular receptors", "SUMOylation of intracellular receptors", "SUMOylation of chromatin organization proteins", "SUMOylation of DNA replication proteins", "SUMOylation of immune response proteins", "Formation of Incision Complex in GG-NER"], "6613": ["Vitamin D (calciferol) metabolism", "SUMO is conjugated to E1 (UBA2:SAE1)", "SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "SUMO is proteolytically processed", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of transcription factors", "SUMOylation of transcription cofactors", "SUMOylation of SUMOylation proteins", "SUMOylation of intracellular receptors", "SUMOylation of intracellular receptors", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "Processing of DNA double-strand break ends", "Formation of Incision Complex in GG-NER"], "6614": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "6615": ["Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription"], "6616": ["Serotonin Neurotransmitter Release Cycle", "Norepinephrine Neurotransmitter Release Cycle", "Glutamate Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle", "Acetylcholine Neurotransmitter Release Cycle", "Regulation of insulin secretion", "Other interleukin signaling", "Toxicity of botulinum toxin type A (BoNT/A)", "Toxicity of botulinum toxin type C (BoNT/C)", "Toxicity of botulinum toxin type E (BoNT/E)", "Neutrophil degranulation", "GABA synthesis, release, reuptake and degradation"], "6617": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "6618": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "6619": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "662": ["COPI-dependent Golgi-to-ER retrograde traffic"], "6620": ["MTF1 activates gene expression"], "6621": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "6622": ["Amyloid fiber formation"], "6624": ["Interleukin-4 and Interleukin-13 signaling"], "6625": ["mRNA Splicing - Major Pathway"], "6626": ["mRNA Splicing - Major Pathway"], "6627": ["mRNA Splicing - Major Pathway", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "6628": ["Cleavage of Growing Transcript in the Termination Region ", "SLBP independent Processing of Histone Pre-mRNAs", "snRNP Assembly", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"], "6629": ["mRNA Splicing - Major Pathway"], "663": ["CDO in myogenesis", "CDO in myogenesis"], "6631": ["mRNA Splicing - Major Pathway"], "6632": ["snRNP Assembly", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "6633": ["snRNP Assembly", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "6634": ["Cleavage of Growing Transcript in the Termination Region ", "SLBP independent Processing of Histone Pre-mRNAs", "snRNP Assembly", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"], "6635": ["Cleavage of Growing Transcript in the Termination Region ", "SLBP independent Processing of Histone Pre-mRNAs", "snRNP Assembly", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"], "6636": ["Cleavage of Growing Transcript in the Termination Region ", "SLBP independent Processing of Histone Pre-mRNAs", "snRNP Assembly", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"], "6637": ["Cleavage of Growing Transcript in the Termination Region ", "SLBP independent Processing of Histone Pre-mRNAs", "snRNP Assembly", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"], "6638": ["mRNA Splicing - Major Pathway"], "6643": ["Golgi Associated Vesicle Biogenesis"], "6646": ["LDL clearance"], "6647": ["Platelet degranulation ", "Detoxification of Reactive Oxygen Species", "Detoxification of Reactive Oxygen Species", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "6648": ["Transcriptional activation of mitochondrial biogenesis", "Detoxification of Reactive Oxygen Species", "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes"], "6649": ["Detoxification of Reactive Oxygen Species", "Detoxification of Reactive Oxygen Species"], "665": ["TP53 Regulates Transcription of Genes Involved in Cytochrome C Release"], "6650": ["Degradation of the extracellular matrix"], "6652": ["Fructose biosynthesis", "Formation of xylulose-5-phosphate"], "6653": ["Amyloid fiber formation"], "6654": ["SOS-mediated signalling", "SOS-mediated signalling", "Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "SHC1 events in ERBB2 signaling", "SHC1 events in ERBB4 signaling", "Signaling by SCF-KIT", "Regulation of KIT signaling", "Signalling to RAS", "Signalling to RAS", "GRB2 events in EGFR signaling", "SHC1 events in EGFR signaling", "Downstream signal transduction", "NRAGE signals death through JNK", "Rho GTPase cycle", "GRB2 events in ERBB2 signaling", "GRB2 events in ERBB2 signaling", "Tie2 Signaling", "EGFR Transactivation by Gastrin", "DAP12 signaling", "SHC-related events triggered by IGF1R", "SHC-related events triggered by IGF1R", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "GRB2:SOS provides linkage to MAPK signaling for Integrins ", "NCAM signaling for neurite out-growth", "G alpha (12/13) signalling events", "Activation of RAC1", "Constitutive Signaling by EGFRvIII", "SHC-mediated cascade:FGFR1", "FRS-mediated FGFR1 signaling", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "Signaling by FGFR2 in disease", "Signaling by FGFR4 in disease", "Signaling by FGFR1 in disease", "RAF/MAP kinase cascade", "Signal attenuation", "Insulin receptor signalling cascade", "Insulin receptor signalling cascade", "MET activates RAS signaling", "Signaling by FGFR3 fusions in cancer", "Signaling by FGFR3 point mutants in cancer", "RET signaling", "Interleukin-15 signaling", "Activated NTRK2 signals through RAS", "Erythropoietin activates RAS", "Activated NTRK2 signals through FRS2 and FRS3", "Activated NTRK2 signals through FRS2 and FRS3", "Activated NTRK3 signals through RAS", "Interleukin receptor SHC signaling", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "6655": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events", "Activation of RAC1", "Interleukin-15 signaling"], "6657": ["POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation", "POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation", "Deactivation of the beta-catenin transactivating complex", "Transcriptional regulation of pluripotent stem cells", "Interleukin-4 and Interleukin-13 signaling", "Transcriptional Regulation by MECP2"], "6658": ["Deactivation of the beta-catenin transactivating complex"], "6659": ["Deactivation of the beta-catenin transactivating complex"], "6662": ["Deactivation of the beta-catenin transactivating complex", "Transcriptional regulation by RUNX2"], "6667": ["PPARA activates gene expression", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Activation of gene expression by SREBF (SREBP)", "Oncogene Induced Senescence", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "Estrogen-dependent gene expression"], "667": ["Assembly of collagen fibrils and other multimeric structures", "Type I hemidesmosome assembly"], "6670": ["SUMOylation of transcription factors"], "6672": ["SUMOylation of DNA damage response and repair proteins", "Interferon gamma signaling"], "6675": ["Synthesis of UDP-N-acetyl-glucosamine"], "6677": ["Interaction With Cumulus Cells"], "6678": ["Platelet degranulation ", "ECM proteoglycans", "Scavenging by Class H Receptors"], "668": ["SUMOylation of transcription factors"], "6687": ["Processing of SMDT1"], "6688": ["RUNX1 regulates transcription of genes involved in differentiation of HSCs"], "669": ["Glycolysis"], "6692": ["MET Receptor Activation", "Signaling by MST1"], "6693": ["Cell surface interactions at the vascular wall", "Basigin interactions"], "6694": ["Platelet degranulation ", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "6696": ["Degradation of the extracellular matrix", "Signaling by PDGF", "Integrin cell surface interactions", "Integrin cell surface interactions", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "RUNX3 Regulates Immune Response and Cell Migration", "Post-translational protein phosphorylation"], "6697": ["Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "eNOS activation"], "6698": ["Formation of the cornified envelope"], "6699": ["Formation of the cornified envelope"], "670": ["POLB-Dependent Long Patch Base Excision Repair", "Phase I - Functionalization of compounds"], "6700": ["Formation of the cornified envelope"], "6701": ["Formation of the cornified envelope"], "6703": ["Formation of the cornified envelope"], "6704": ["Formation of the cornified envelope"], "6705": ["Formation of the cornified envelope"], "6706": ["Formation of the cornified envelope"], "6707": ["Formation of the cornified envelope"], "6708": ["NCAM signaling for neurite out-growth", "NCAM signaling for neurite out-growth", "Interaction between L1 and Ankyrins", "Interaction between L1 and Ankyrins", "RAF/MAP kinase cascade", "COPI-mediated anterograde transport"], "6709": ["Caspase-mediated cleavage of cytoskeletal proteins", "Nephrin family interactions", "NCAM signaling for neurite out-growth", "NCAM signaling for neurite out-growth", "Interaction between L1 and Ankyrins", "Interaction between L1 and Ankyrins", "RAF/MAP kinase cascade", "Neutrophil degranulation", "COPI-mediated anterograde transport"], "671": ["Toll Like Receptor 4 (TLR4) Cascade", "Neutrophil degranulation", "Antimicrobial peptides"], "6710": ["NCAM signaling for neurite out-growth", "NCAM signaling for neurite out-growth", "Interaction between L1 and Ankyrins", "Interaction between L1 and Ankyrins", "RAF/MAP kinase cascade", "COPI-mediated anterograde transport"], "6711": ["Nephrin family interactions", "NCAM signaling for neurite out-growth", "NCAM signaling for neurite out-growth", "Interaction between L1 and Ankyrins", "Interaction between L1 and Ankyrins", "RAF/MAP kinase cascade", "COPI-mediated anterograde transport"], "6712": ["MHC class II antigen presentation", "NCAM signaling for neurite out-growth", "NCAM signaling for neurite out-growth", "Interaction between L1 and Ankyrins", "Interaction between L1 and Ankyrins", "RAF/MAP kinase cascade", "COPI-mediated anterograde transport"], "6713": ["Cholesterol biosynthesis", "Activation of gene expression by SREBF (SREBP)"], "6714": ["Signaling by ERBB2", "Nuclear signaling by ERBB4", "PIP3 activates AKT signaling", "Spry regulation of FGF signaling", "Signaling by SCF-KIT", "Signaling by SCF-KIT", "Regulation of KIT signaling", "p38MAPK events", "Signaling by EGFR", "GAB1 signalosome", "Downstream signal transduction", "c-src mediated regulation of Cx43 function and closure of gap junctions", "FCGR activation", "PECAM1 interactions", "Constitutive Signaling by Aberrant PI3K in Cancer", "EPH-Ephrin signaling", "Integrin alphaIIb beta3 signaling", "GRB2:SOS provides linkage to MAPK signaling for Integrins ", "p130Cas linkage to MAPK signaling for integrins", "NCAM signaling for neurite out-growth", "CD28 co-stimulation", "CTLA4 inhibitory signaling", "Signal regulatory protein family interactions", "EPHB-mediated forward signaling", "EPHB-mediated forward signaling", "EPHA-mediated growth cone collapse", "EPHA-mediated growth cone collapse", "Ephrin signaling", "Ephrin signaling", "EPH-ephrin mediated repulsion of cells", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "DCC mediated attractive signaling", "DCC mediated attractive signaling", "Netrin mediated repulsion signals", "Regulation of commissural axon pathfinding by SLIT and ROBO", "GP1b-IX-V activation signalling", "Recycling pathway of L1", "VEGFA-VEGFR2 Pathway", "VEGFA-VEGFR2 Pathway", "Thrombin signalling through proteinase activated receptors (PARs)", "VEGFR2 mediated cell proliferation", "CLEC7A (Dectin-1) signaling", "RHO GTPases Activate Formins", "RAF activation", "MAP2K and MAPK activation", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Cyclin D associated events in G1", "RET signaling", "MET activates PTK2 signaling", "InlA-mediated entry of Listeria monocytogenes into host cells", "Regulation of RUNX1 Expression and Activity", "Receptor Mediated Mitophagy", "RUNX2 regulates osteoblast differentiation", "Regulation of RUNX3 expression and activity", "Activated NTRK2 signals through FYN", "Activated NTRK3 signals through PI3K", "Activated NTRK3 signals through PI3K", "Long-term potentiation"], "6715": ["Androgen biosynthesis"], "6716": ["Androgen biosynthesis"], "6717": ["Stimuli-sensing channels", "Reduction of cytosolic Ca++ levels", "Sodium/Calcium exchangers", "Ion homeostasis", "Ion transport by P-type ATPases"], "6718": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of bile acids and bile salts via 24-hydroxycholesterol", "Synthesis of bile acids and bile salts via 27-hydroxycholesterol"], "672": ["Meiotic synapsis", "SUMOylation of DNA damage response and repair proteins", "HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Metalloprotease DUBs", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Nonhomologous End-Joining (NHEJ)", "Homologous DNA Pairing and Strand Exchange", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "TP53 Regulates Transcription of DNA Repair Genes", "Regulation of TP53 Activity through Phosphorylation", "G2/M DNA damage checkpoint", "Transcriptional Regulation by E2F6", "Meiotic recombination"], "6720": ["RORA activates gene expression", "Regulation of cholesterol biosynthesis by SREBP (SREBF)", "Regulation of cholesterol biosynthesis by SREBP (SREBF)", "PPARA activates gene expression", "Activation of gene expression by SREBF (SREBP)", "Activation of gene expression by SREBF (SREBP)", "Transcriptional regulation of white adipocyte differentiation", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes"], "6721": ["Regulation of cholesterol biosynthesis by SREBP (SREBF)", "Regulation of cholesterol biosynthesis by SREBP (SREBF)", "PPARA activates gene expression", "Activation of gene expression by SREBF (SREBP)", "Activation of gene expression by SREBF (SREBP)", "Transcriptional regulation of white adipocyte differentiation"], "6722": ["RHO GTPases Activate Formins"], "6723": ["Metabolism of polyamines"], "6725": ["PTK6 Down-Regulation"], "6726": ["SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane"], "6727": ["SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Neutrophil degranulation"], "6728": ["SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane"], "6729": ["SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane"], "673": ["Spry regulation of FGF signaling", "Frs2-mediated activation", "ARMS-mediated activation", "Signalling to p38 via RIT and RIN", "RAF activation", "MAP2K and MAPK activation", "Negative feedback regulation of MAPK pathway", "Negative regulation of MAPK pathway", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF"], "6730": ["SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane"], "6731": ["SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane"], "6734": ["SRP-dependent cotranslational protein targeting to membrane", "XBP1(S) activates chaperone genes"], "6736": ["Deactivation of the beta-catenin transactivating complex"], "6737": ["STING mediated induction of host immune responses", "Regulation of innate immune responses to cytosolic DNA", "Interferon gamma signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "6741": ["RNA Polymerase III Transcription Termination", "RNA Polymerase III Abortive And Retractive Initiation"], "6742": ["Transcriptional activation of mitochondrial biogenesis"], "6745": ["SRP-dependent cotranslational protein targeting to membrane", "XBP1(S) activates chaperone genes"], "6746": ["SRP-dependent cotranslational protein targeting to membrane"], "6747": ["SRP-dependent cotranslational protein targeting to membrane"], "6748": ["SRP-dependent cotranslational protein targeting to membrane"], "6749": ["Formation of RNA Pol II elongation complex ", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "Regulation of TP53 Activity through Phosphorylation", "RNA Polymerase II Transcription Elongation"], "675": ["HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange", "Presynaptic phase of homologous DNA pairing and strand exchange", "Meiotic recombination"], "6750": ["Peptide ligand-binding receptors", "G alpha (i) signalling events", "MECP2 regulates transcription of neuronal ligands"], "6751": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "6752": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "6753": ["Peptide ligand-binding receptors", "G alpha (i) signalling events", "BBSome-mediated cargo-targeting to cilium"], "6754": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "6755": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "6764": ["RAB GEFs exchange GTP for GDP on RABs"], "6767": ["Regulation of HSF1-mediated heat shock response"], "6768": ["Formation of the cornified envelope", "Formation of the cornified envelope"], "677": ["Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA"], "6770": ["Pregnenolone biosynthesis"], "6772": ["Interleukin-6 signaling", "ISG15 antiviral mechanism", "Signaling by SCF-KIT", "Signaling by cytosolic FGFR1 fusion mutants", "Downstream signal transduction", "Interleukin-4 and Interleukin-13 signaling", "Interferon gamma signaling", "Regulation of IFNG signaling", "Interleukin-20 family signaling", "Regulation of RUNX2 expression and activity", "Interleukin-35 Signalling", "Interleukin-9 signaling", "NOTCH3 Intracellular Domain Regulates Transcription", "NOTCH3 Intracellular Domain Regulates Transcription", "Interleukin-27 signaling", "Interleukin-21 signaling", "Interferon alpha/beta signaling", "Regulation of IFNA signaling", "Growth hormone receptor signaling"], "6773": ["Interleukin-20 family signaling", "Interferon alpha/beta signaling", "Regulation of IFNA signaling", "Regulation of IFNA signaling"], "6774": ["Interleukin-6 signaling", "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "Interleukin-7 signaling", "Interleukin-7 signaling", "Signaling by SCF-KIT", "Signaling by cytosolic FGFR1 fusion mutants", "Downstream signal transduction", "Signalling to STAT3", "Senescence-Associated Secretory Phenotype (SASP)", "Signaling by Leptin", "POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation", "Association of TriC/CCT with target proteins during biosynthesis", "Transcriptional regulation of pluripotent stem cells", "Interleukin-10 signaling", "Interleukin-4 and Interleukin-13 signaling", "PTK6 Activates STAT3", "PTK6 Activates STAT3", "Interleukin-20 family signaling", "MET activates STAT3", "MET activates STAT3", "Interleukin-15 signaling", "Interleukin-35 Signalling", "Interleukin-9 signaling", "Interleukin-37 signaling", "Interleukin-23 signaling", "Interleukin-23 signaling", "Interleukin-27 signaling", "Interleukin-21 signaling", "Growth hormone receptor signaling"], "6775": ["Interleukin-20 family signaling", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "Interleukin-35 Signalling", "Interleukin-12 signaling", "Interleukin-12 signaling", "Interleukin-23 signaling", "Interleukin-21 signaling"], "6776": ["Prolactin receptor signaling", "Nuclear signaling by ERBB4", "Interleukin-7 signaling", "Interleukin-7 signaling", "Signaling by SCF-KIT", "Signaling by cytosolic FGFR1 fusion mutants", "Downstream signal transduction", "Signaling by Leptin", "Signaling by Leptin", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "Interleukin-20 family signaling", "Interleukin-15 signaling", "Interleukin-9 signaling", "Interleukin-2 signaling", "Interleukin-2 signaling", "Interleukin-21 signaling", "Erythropoietin activates STAT5", "Growth hormone receptor signaling", "Growth hormone receptor signaling"], "6777": ["Prolactin receptor signaling", "Interleukin-7 signaling", "Interleukin-7 signaling", "Signaling by SCF-KIT", "Signaling by cytosolic FGFR1 fusion mutants", "Downstream signal transduction", "Signaling by Leptin", "Signaling by Leptin", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "Interleukin-20 family signaling", "Interleukin-15 signaling", "Interleukin-9 signaling", "Interleukin-2 signaling", "Interleukin-2 signaling", "Interleukin-21 signaling", "Erythropoietin activates STAT5", "Growth hormone receptor signaling", "Growth hormone receptor signaling"], "6778": ["Downstream signal transduction", "STAT6-mediated induction of chemokines", "Interleukin-4 and Interleukin-13 signaling"], "6782": ["Regulation of HSF1-mediated heat shock response"], "6783": ["Cytosolic sulfonation of small molecules"], "6785": ["Synthesis of very long-chain fatty acyl-CoAs"], "6786": ["Elevation of cytosolic Ca2+ levels", "Ion homeostasis", "Ion homeostasis", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "6788": ["Signaling by Hippo"], "6789": ["Signaling by Hippo"], "6790": ["APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Regulation of PLK1 Activity at G2/M Transition", "SUMOylation of DNA replication proteins", "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "Regulation of TP53 Activity through Phosphorylation", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "AURKA Activation by TPX2", "Interaction between PHLDA1 and AURKA"], "6793": ["Neutrophil degranulation"], "6794": ["AMPK inhibits chREBP transcriptional activation activity", "Energy dependent regulation of mTOR by LKB1-AMPK", "Regulation of TP53 Activity through Phosphorylation", "FOXO-mediated transcription of cell death genes"], "6799": ["Cytosolic sulfonation of small molecules"], "680": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "6804": ["Serotonin Neurotransmitter Release Cycle", "Norepinephrine Neurotransmitter Release Cycle", "Glutamate Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle", "Acetylcholine Neurotransmitter Release Cycle", "Insulin processing", "Regulation of insulin secretion", "Other interleukin signaling", "Toxicity of botulinum toxin type C (BoNT/C)", "LGI-ADAM interactions", "Neurexins and neuroligins", "GABA synthesis, release, reuptake and degradation"], "6809": ["Other interleukin signaling"], "6810": ["Disinhibition of SNARE formation", "ER-Phagosome pathway", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Clathrin derived vesicle budding", "Other interleukin signaling"], "6811": ["COPII-mediated vesicle transport", "Cargo concentration in the ER", "COPI-mediated anterograde transport", "Intra-Golgi traffic"], "6812": ["Serotonin Neurotransmitter Release Cycle", "Norepinephrine Neurotransmitter Release Cycle", "Glutamate Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle", "Acetylcholine Neurotransmitter Release Cycle", "Regulation of insulin secretion", "Neurexins and neuroligins", "GABA synthesis, release, reuptake and degradation"], "6813": ["Platelet degranulation ", "Other interleukin signaling"], "6814": ["Disinhibition of SNARE formation", "Translocation of SLC2A4 (GLUT4) to the plasma membrane"], "6817": ["Cytosolic sulfonation of small molecules"], "6818": ["Cytosolic sulfonation of small molecules", "XBP1(S) activates chaperone genes"], "6819": ["Cytosolic sulfonation of small molecules"], "682": ["Degradation of the extracellular matrix", "Basigin interactions", "Integrin cell surface interactions", "Proton-coupled monocarboxylate transport", "Pyruvate metabolism"], "6820": ["Cytosolic sulfonation of small molecules"], "6821": ["Sulfide oxidation to sulfate"], "6822": ["Cytosolic sulfonation of small molecules", "PPARA activates gene expression"], "6827": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Abortive elongation of HIV-1 transcript in the absence of Tat", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Transcription Elongation"], "6829": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Abortive elongation of HIV-1 transcript in the absence of Tat", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "RNA Polymerase II Transcription Elongation", "RNA Pol II CTD phosphorylation and interaction with CE"], "683": ["Post-translational modification: synthesis of GPI-anchored proteins", "Nicotinate metabolism", "Neutrophil degranulation"], "6830": ["Formation of RNA Pol II elongation complex ", "RNA Polymerase II Pre-transcription Events", "RNA Polymerase II Transcription Elongation"], "6833": ["ATP sensitive Potassium channels", "Regulation of insulin secretion", "Defective ABCC8 can cause hypoglycemias and hyperglycemias"], "6834": ["TP53 Regulates Metabolic Genes", "Respiratory electron transport"], "6836": ["Neutrophil degranulation", "COPI-dependent Golgi-to-ER retrograde traffic"], "6837": ["PPARA activates gene expression", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "6839": ["PKMTs methylate histone lysines", "SIRT1 negatively regulates rRNA expression"], "684": ["Neutrophil degranulation", "Interferon alpha/beta signaling"], "6843": ["Toxicity of botulinum toxin type D (BoNT/D)", "Toxicity of botulinum toxin type F (BoNT/F)", "Toxicity of botulinum toxin type G (BoNT/G)"], "6844": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Serotonin Neurotransmitter Release Cycle", "Norepinephrine Neurotransmitter Release Cycle", "Glutamate Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle", "Acetylcholine Neurotransmitter Release Cycle", "Insulin processing", "Clathrin derived vesicle budding", "Regulation of insulin secretion", "Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis", "Other interleukin signaling", "Toxicity of botulinum toxin type D (BoNT/D)", "Toxicity of botulinum toxin type B (BoNT/B)", "Toxicity of botulinum toxin type F (BoNT/F)", "Toxicity of tetanus toxin (TeNT)", "Toxicity of botulinum toxin type G (BoNT/G)", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "GABA synthesis, release, reuptake and degradation"], "6845": ["Clathrin derived vesicle budding", "Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "Interleukin-12 signaling"], "6846": ["Chemokine receptors bind chemokines", "G alpha (q) signalling events"], "6847": ["Meiotic synapsis"], "685": ["Signaling by ERBB2", "Signaling by ERBB4", "SHC1 events in ERBB2 signaling", "SHC1 events in ERBB2 signaling", "PI3K events in ERBB4 signaling", "SHC1 events in ERBB4 signaling", "Nuclear signaling by ERBB4", "PIP3 activates AKT signaling", "Signaling by EGFR", "GRB2 events in EGFR signaling", "GAB1 signalosome", "SHC1 events in EGFR signaling", "EGFR downregulation", "GRB2 events in ERBB2 signaling", "PI3K events in ERBB2 signaling", "EGFR interacts with phospholipase C-gamma", "Constitutive Signaling by Aberrant PI3K in Cancer", "Inhibition of Signaling by Overexpressed EGFR", "RAF/MAP kinase cascade", "ERBB2 Regulates Cell Motility", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "ERBB2 Activates PTK6 Signaling", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "Downregulation of ERBB2 signaling"], "6850": ["GPVI-mediated activation cascade", "GPVI-mediated activation cascade", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "DAP12 signaling", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "Integrin alphaIIb beta3 signaling", "CLEC7A (Dectin-1) signaling", "Dectin-2 family", "Dectin-2 family", "Interleukin-2 signaling", "Regulation of signaling by CBL", "Regulation of signaling by CBL", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "6853": ["Serotonin Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle"], "6854": ["Serotonin Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle"], "6857": ["Serotonin Neurotransmitter Release Cycle", "Norepinephrine Neurotransmitter Release Cycle", "Glutamate Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle", "Acetylcholine Neurotransmitter Release Cycle", "Toxicity of botulinum toxin type B (BoNT/B)", "Toxicity of botulinum toxin type G (BoNT/G)", "Neurexins and neuroligins", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "GABA synthesis, release, reuptake and degradation"], "686": ["Biotin transport and metabolism", "Defective BTD causes biotidinase deficiency"], "6861": ["Regulation of insulin secretion"], "6863": ["Tachykinin receptors bind tachykinins", "G alpha (q) signalling events"], "6865": ["Tachykinin receptors bind tachykinins", "G alpha (q) signalling events"], "6866": ["Tachykinin receptors bind tachykinins", "G alpha (q) signalling events"], "6868": ["Nuclear signaling by ERBB4", "Collagen degradation", "Signaling by EGFR", "Regulated proteolysis of p75NTR", "Activated NOTCH1 Transmits Signal to the Nucleus", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant", "Constitutive Signaling by NOTCH1 HD Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "Release of Hh-Np from the secreting cell", "TNF signaling", "Growth hormone receptor signaling"], "6869": ["Tachykinin receptors bind tachykinins", "G alpha (q) signalling events", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "6870": ["Tachykinin receptors bind tachykinins", "G alpha (q) signalling events"], "6871": ["HATs acetylate histones"], "6872": ["HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "6873": ["HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "6874": ["HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "6875": ["HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "6877": ["HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "6878": ["HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "6879": ["HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "688": ["Transcriptional regulation of white adipocyte differentiation"], "6880": ["HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "HATs acetylate histones", "RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "6881": ["HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "HATs acetylate histones", "Ub-specific processing proteases", "RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "6882": ["HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "6883": ["HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "HATs acetylate histones", "RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "6884": ["HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "6885": ["Activation of NF-kappaB in B cells", "NOD1/2 Signaling Pathway", "Downstream TCR signaling", "FCERI mediated NF-kB activation", "Ca2+ pathway", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "activated TAK1 mediates p38 MAPK activation", "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "TNFR1-induced NFkappaB signaling pathway", "CLEC7A (Dectin-1) signaling", "Ub-specific processing proteases", "TICAM1,TRAF6-dependent induction of TAK1 complex", "Interleukin-1 signaling", "IRAK2 mediated activation of TAK1 complex", "TRAF6-mediated induction of TAK1 complex within TLR4 complex", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"], "6886": ["RUNX1 regulates transcription of genes involved in differentiation of HSCs"], "6888": ["Insulin effects increased synthesis of Xylulose-5-Phosphate", "TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P", "TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P", "Pentose phosphate pathway", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "6890": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "6891": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "6892": ["ER-Phagosome pathway", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "6895": ["MicroRNA (miRNA) biogenesis", "Small interfering RNA (siRNA) biogenesis"], "6897": ["Cytosolic tRNA aminoacylation"], "6898": ["Phenylalanine and tyrosine catabolism"], "6900": ["L1CAM interactions", "NCAM1 interactions", "NrCAM interactions"], "6901": ["Mitochondrial protein import", "Mitochondrial protein import", "Acyl chain remodeling of CL"], "6902": ["Post-chaperonin tubulin folding pathway"], "6903": ["Post-chaperonin tubulin folding pathway"], "6904": ["Post-chaperonin tubulin folding pathway"], "6905": ["Post-chaperonin tubulin folding pathway"], "6907": ["RORA activates gene expression", "BMAL1:CLOCK,NPAS2 activates circadian gene expression", "PPARA activates gene expression", "PPARA activates gene expression", "NOTCH1 Intracellular Domain Regulates Transcription", "Transcriptional activation of mitochondrial biogenesis", "Activation of gene expression by SREBF (SREBP)", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "HDACs deacetylate histones", "Transcriptional regulation of white adipocyte differentiation", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)", "Circadian Clock", "Loss of MECP2 binding ability to the NCoR/SMRT complex", "Regulation of MECP2 expression and activity"], "6908": ["HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase I Transcription Termination", "RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "Estrogen-dependent gene expression"], "6910": ["YAP1- and WWTR1 (TAZ)-stimulated gene expression", "Physiological factors"], "6915": ["Prostanoid ligand receptors", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "Thromboxane signalling through TP receptor"], "6916": ["Eicosanoids", "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD)"], "6917": ["Formation of RNA Pol II elongation complex ", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "RNA Polymerase II Transcription Elongation"], "6921": ["Formation of RNA Pol II elongation complex ", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "Vif-mediated degradation of APOBEC3G", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "RNA Polymerase II Transcription Elongation", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Antigen processing: Ubiquitination & Proteasome degradation"], "6923": ["Formation of RNA Pol II elongation complex ", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "Vif-mediated degradation of APOBEC3G", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "RNA Polymerase II Transcription Elongation", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Antigen processing: Ubiquitination & Proteasome degradation"], "6924": ["Formation of RNA Pol II elongation complex ", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "RNA Polymerase II Transcription Elongation"], "6925": ["CDO in myogenesis", "CDO in myogenesis"], "6927": ["Regulation of gene expression in beta cells"], "6928": ["Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "Regulation of gene expression in early pancreatic precursor cells"], "6929": ["CDO in myogenesis", "CDO in myogenesis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs"], "6932": ["Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "Deactivation of the beta-catenin transactivating complex", "Ca2+ pathway", "Binding of TCF/LEF:CTNNB1 to target gene promoters", "Repression of WNT target genes", "Repression of WNT target genes", "RUNX3 regulates WNT signaling"], "6934": ["Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "Deactivation of the beta-catenin transactivating complex", "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "Ca2+ pathway", "Binding of TCF/LEF:CTNNB1 to target gene promoters", "Repression of WNT target genes", "Repression of WNT target genes", "TCF7L2 mutants don't bind CTBP", "RUNX3 regulates WNT signaling"], "6935": ["Interleukin-4 and Interleukin-13 signaling"], "6936": ["mRNA Splicing - Major Pathway"], "6938": ["CDO in myogenesis", "CDO in myogenesis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs"], "694": ["FOXO-mediated transcription of cell cycle genes"], "6940": ["Generic Transcription Pathway"], "6944": ["HATs acetylate histones"], "6945": ["ChREBP activates metabolic gene expression", "ChREBP activates metabolic gene expression"], "6947": ["Cobalamin (Cbl, vitamin B12) transport and metabolism", "Neutrophil degranulation"], "6948": ["Cobalamin (Cbl, vitamin B12) transport and metabolism", "Defective TCN2 causes hereditary megaloblastic anemia", "Defective CD320 causes methylmalonic aciduria"], "695": ["ER-Phagosome pathway", "MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "Regulation of actin dynamics for phagocytic cup formation", "DAP12 signaling", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "MyD88 deficiency (TLR2/4)", "IRAK4 deficiency (TLR2/4)", "RHO GTPases Activate WASPs and WAVEs", "G beta:gamma signalling through BTK", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "6950": ["Prefoldin mediated transfer of substrate to CCT/TriC", "Formation of tubulin folding intermediates by CCT/TriC", "Folding of actin by CCT/TriC", "Association of TriC/CCT with target proteins during biosynthesis", "Association of TriC/CCT with target proteins during biosynthesis", "BBSome-mediated cargo-targeting to cilium", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "696": ["Butyrophilin (BTN) family interactions"], "6975": ["Post-translational modification: synthesis of GPI-anchored proteins"], "699": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "6991": ["Intraflagellar transport"], "6993": ["Neutrophil degranulation"], "6996": ["Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "Cleavage of the damaged pyrimidine ", "Displacement of DNA glycosylase by APEX1", "SUMOylation of DNA damage response and repair proteins", "TET1,2,3 and TDG demethylate DNA"], "6997": ["Signaling by NODAL", "Regulation of signaling by NODAL", "POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation"], "6999": ["Tryptophan catabolism"], "70": ["Striated Muscle Contraction"], "7001": ["Detoxification of Reactive Oxygen Species", "TP53 Regulates Metabolic Genes", "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models"], "7003": ["YAP1- and WWTR1 (TAZ)-stimulated gene expression", "RUNX3 regulates YAP1-mediated transcription"], "7004": ["YAP1- and WWTR1 (TAZ)-stimulated gene expression", "RUNX3 regulates YAP1-mediated transcription"], "7005": ["YAP1- and WWTR1 (TAZ)-stimulated gene expression", "RUNX3 regulates YAP1-mediated transcription"], "7006": ["Signaling by SCF-KIT", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "Interleukin-3, Interleukin-5 and GM-CSF signaling"], "7007": ["Post-translational modification: synthesis of GPI-anchored proteins"], "701": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "APC/C:Cdc20 mediated degradation of mitotic proteins", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "7010": ["Tie2 Signaling", "Tie2 Signaling", "RAF/MAP kinase cascade"], "7013": ["Meiotic synapsis", "Packaging Of Telomere Ends", "DNA Damage/Telomere Stress Induced Senescence"], "7014": ["Meiotic synapsis", "Packaging Of Telomere Ends", "DNA Damage/Telomere Stress Induced Senescence"], "7015": ["Telomere Extension By Telomerase", "Formation of the beta-catenin:TCF transactivating complex"], "7016": ["Regulation of cytoskeletal remodeling and cell spreading by IPP complex components"], "7018": ["Platelet degranulation ", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "Post-translational protein phosphorylation", "Iron uptake and transport", "Transferrin endocytosis and recycling"], "7019": ["Mitochondrial transcription initiation", "Transcriptional activation of mitochondrial biogenesis", "Transcriptional activation of mitochondrial biogenesis"], "7020": ["SUMOylation of transcription factors", "Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors", "Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "TFAP2 (AP-2) family regulates transcription of other transcription factors", "Activation of the TFAP2 (AP-2) family of transcription factors", "TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "TFAP2 (AP-2) family regulates transcription of cell cycle factors", "TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation"], "7021": ["SUMOylation of transcription factors", "Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "Activation of the TFAP2 (AP-2) family of transcription factors", "TFAP2 (AP-2) family regulates transcription of growth factors and their receptors"], "7022": ["SUMOylation of transcription factors", "Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "TFAP2 (AP-2) family regulates transcription of other transcription factors", "Activation of the TFAP2 (AP-2) family of transcription factors", "TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "TFAP2 (AP-2) family regulates transcription of cell cycle factors"], "7025": ["Nuclear Receptor transcription pathway"], "7026": ["Transcriptional regulation of white adipocyte differentiation"], "7027": ["Activation of NOXA and translocation to mitochondria", "Inhibition of replication initiation of damaged DNA by RB1/E2F1", "Transcription of E2F targets under negative control by DREAM complex", "Transcription of E2F targets under negative control by DREAM complex", "Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1", "Activation of PUMA and translocation to mitochondria", "G0 and Early G1", "Pre-NOTCH Transcription and Translation", "Pre-NOTCH Transcription and Translation", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Oxidative Stress Induced Senescence", "Oncogene Induced Senescence", "Activation of E2F1 target genes at G1/S", "Activation of E2F1 target genes at G1/S", "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "Cyclin E associated events during G1/S transition ", "Cyclin D associated events in G1", "Cyclin A:Cdk2-associated events at S phase entry", "Transcriptional Regulation by E2F6"], "7029": ["Activation of NOXA and translocation to mitochondria", "Inhibition of replication initiation of damaged DNA by RB1/E2F1", "Transcription of E2F targets under negative control by DREAM complex", "Transcription of E2F targets under negative control by DREAM complex", "Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1", "Activation of PUMA and translocation to mitochondria", "G0 and Early G1", "Pre-NOTCH Transcription and Translation", "Pre-NOTCH Transcription and Translation", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Oxidative Stress Induced Senescence", "Oncogene Induced Senescence", "Activation of E2F1 target genes at G1/S", "Activation of E2F1 target genes at G1/S", "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "Cyclin E associated events during G1/S transition ", "Cyclin D associated events in G1", "Cyclin A:Cdk2-associated events at S phase entry", "Transcriptional Regulation by E2F6"], "7031": ["Estrogen-dependent gene expression"], "7033": ["Estrogen-dependent gene expression"], "7035": ["Extrinsic Pathway of Fibrin Clot Formation"], "7036": ["Transferrin endocytosis and recycling"], "7037": ["Golgi Associated Vesicle Biogenesis", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "Transferrin endocytosis and recycling"], "7039": ["PIP3 activates AKT signaling", "Signaling by EGFR", "GRB2 events in EGFR signaling", "GAB1 signalosome", "SHC1 events in EGFR signaling", "EGFR downregulation", "COPII-mediated vesicle transport", "EGFR interacts with phospholipase C-gamma", "Constitutive Signaling by Aberrant PI3K in Cancer", "Inhibition of Signaling by Overexpressed EGFR", "RAF/MAP kinase cascade", "Cargo concentration in the ER", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "Estrogen-dependent gene expression"], "7040": ["Platelet degranulation ", "Influenza Virus Induced Apoptosis", "Cell surface interactions at the vascular wall", "Molecules associated with elastic fibres", "Downregulation of TGF-beta receptor signaling", "Downregulation of TGF-beta receptor signaling", "TGF-beta receptor signaling activates SMADs", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "Syndecan interactions", "ECM proteoglycans", "SMAD2/3 Phosphorylation Motif Mutants in Cancer", "SMAD2/3 MH2 Domain Mutants in Cancer", "TGFBR2 MSI Frameshift Mutants in Cancer", "TGFBR2 Kinase Domain Mutants in Cancer", "TGFBR1 KD Mutants in Cancer", "TGFBR1 LBD Mutants in Cancer", "Transcriptional regulation of white adipocyte differentiation", "UCH proteinases", "Interleukin-4 and Interleukin-13 signaling", "RUNX3 regulates CDKN1A transcription", "Regulation of RUNX3 expression and activity", "RUNX3 regulates p14-ARF"], "7042": ["Platelet degranulation ", "Molecules associated with elastic fibres", "ECM proteoglycans"], "7043": ["Platelet degranulation ", "Molecules associated with elastic fibres", "ECM proteoglycans"], "7044": ["Platelet degranulation ", "Signaling by NODAL", "Regulation of signaling by NODAL"], "7045": ["Amyloid fiber formation"], "7046": ["Downregulation of TGF-beta receptor signaling", "Downregulation of TGF-beta receptor signaling", "TGF-beta receptor signaling activates SMADs", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "SMAD2/3 Phosphorylation Motif Mutants in Cancer", "SMAD2/3 MH2 Domain Mutants in Cancer", "TGFBR2 Kinase Domain Mutants in Cancer", "TGFBR1 KD Mutants in Cancer", "TGFBR1 LBD Mutants in Cancer", "UCH proteinases", "Ub-specific processing proteases"], "7048": ["Downregulation of TGF-beta receptor signaling", "Downregulation of TGF-beta receptor signaling", "TGF-beta receptor signaling activates SMADs", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "SMAD2/3 Phosphorylation Motif Mutants in Cancer", "SMAD2/3 MH2 Domain Mutants in Cancer", "TGFBR2 MSI Frameshift Mutants in Cancer", "TGFBR2 Kinase Domain Mutants in Cancer", "TGFBR1 KD Mutants in Cancer", "TGFBR1 LBD Mutants in Cancer", "UCH proteinases"], "705": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "7050": ["Downregulation of SMAD2/3:SMAD4 transcriptional activity", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription"], "7051": ["Formation of the cornified envelope"], "7054": ["Catecholamine biosynthesis"], "7056": ["Common Pathway of Fibrin Clot Formation", "Cell surface interactions at the vascular wall"], "7057": ["Platelet degranulation ", "Signaling by PDGF", "Integrin cell surface interactions", "Syndecan interactions", "Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"], "7058": ["Signaling by PDGF", "Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "7059": ["Signaling by PDGF"], "706": ["Pregnenolone biosynthesis"], "7060": ["Signaling by PDGF"], "7062": ["Formation of the cornified envelope"], "7064": ["Antigen processing: Ubiquitination & Proteasome degradation"], "7066": ["Platelet Aggregation (Plug Formation)"], "7067": ["Nuclear Receptor transcription pathway", "SUMOylation of intracellular receptors"], "7068": ["Nuclear Receptor transcription pathway", "SUMOylation of intracellular receptors"], "7069": ["Import of palmitoyl-CoA into the mitochondrial matrix"], "7070": ["Post-translational modification: synthesis of GPI-anchored proteins"], "7072": ["FGFR2 alternative splicing"], "7073": ["FGFR2 alternative splicing"], "7074": ["NRAGE signals death through JNK", "Rho GTPase cycle", "EPHB-mediated forward signaling", "EPH-ephrin mediated repulsion of cells", "G alpha (12/13) signalling events", "Activated NTRK2 signals through CDK5"], "7076": ["Platelet degranulation ", "Activation of Matrix Metalloproteinases", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Interleukin-10 signaling", "Interleukin-4 and Interleukin-13 signaling", "Post-translational protein phosphorylation"], "7077": ["Activation of Matrix Metalloproteinases", "Neutrophil degranulation"], "7078": ["Platelet degranulation "], "708": ["Intrinsic Pathway of Fibrin Clot Formation"], "7082": ["c-src mediated regulation of Cx43 function and closure of gap junctions", "c-src mediated regulation of Cx43 function and closure of gap junctions", "Signaling by Hippo", "Apoptotic cleavage of cell adhesion proteins", "RUNX1 regulates expression of components of tight junctions"], "7083": ["Activation of E2F1 target genes at G1/S", "Pyrimidine salvage"], "7084": ["Pyrimidine salvage"], "7086": ["Insulin effects increased synthesis of Xylulose-5-Phosphate", "Pentose phosphate pathway"], "7087": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Integrin cell surface interactions"], "7088": ["Formation of the beta-catenin:TCF transactivating complex", "NOTCH1 Intracellular Domain Regulates Transcription", "Deactivation of the beta-catenin transactivating complex", "Repression of WNT target genes", "Repression of WNT target genes"], "7089": ["Formation of the beta-catenin:TCF transactivating complex", "NOTCH1 Intracellular Domain Regulates Transcription", "Deactivation of the beta-catenin transactivating complex", "Repression of WNT target genes", "Repression of WNT target genes"], "7090": ["Formation of the beta-catenin:TCF transactivating complex", "NOTCH1 Intracellular Domain Regulates Transcription", "Deactivation of the beta-catenin transactivating complex", "Repression of WNT target genes", "Repression of WNT target genes", "Estrogen-dependent gene expression"], "7091": ["Formation of the beta-catenin:TCF transactivating complex", "NOTCH1 Intracellular Domain Regulates Transcription", "Deactivation of the beta-catenin transactivating complex", "Repression of WNT target genes", "Repression of WNT target genes"], "7092": ["Degradation of the extracellular matrix", "Collagen biosynthesis and modifying enzymes", "Anchoring fibril formation", "Crosslinking of collagen fibrils"], "7093": ["Degradation of the extracellular matrix", "Collagen biosynthesis and modifying enzymes", "Anchoring fibril formation", "Crosslinking of collagen fibrils"], "7094": ["Platelet degranulation ", "Integrin alphaIIb beta3 signaling", "GRB2:SOS provides linkage to MAPK signaling for Integrins ", "p130Cas linkage to MAPK signaling for integrins", "XBP1(S) activates chaperone genes", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "Smooth Muscle Contraction", "MAP2K and MAPK activation", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF"], "7095": ["XBP1(S) activates chaperone genes"], "7096": ["ER-Phagosome pathway", "Beta defensins", "MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "Toll Like Receptor TLR1:TLR2 Cascade", "MyD88 deficiency (TLR2/4)", "IRAK4 deficiency (TLR2/4)", "Regulation of TLR by endogenous ligand"], "7097": ["ER-Phagosome pathway", "Beta defensins", "MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "Toll Like Receptor TLR1:TLR2 Cascade", "Toll Like Receptor TLR6:TLR2 Cascade", "MyD88 deficiency (TLR2/4)", "IRAK4 deficiency (TLR2/4)", "Regulation of TLR by endogenous ligand", "Neutrophil degranulation"], "7098": ["Trafficking and processing of endosomal TLR", "Toll Like Receptor 3 (TLR3) Cascade", "TICAM1, RIP1-mediated IKK complex recruitment ", "RIP-mediated NFkB activation via ZBP1", "TLR3 deficiency - HSE", "UNC93B1 deficiency - HSE", "TICAM1 deficiency - HSE", "TRAF3 deficiency - HSE", "TLR3-mediated TICAM1-dependent programmed cell death", "TICAM1-dependent activation of IRF3/IRF7", "TICAM1,TRAF6-dependent induction of TAK1 complex"], "7099": ["ER-Phagosome pathway", "Caspase activation via Death Receptors in the presence of ligand", "Toll Like Receptor 4 (TLR4) Cascade", "MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "MyD88-independent TLR4 cascade ", "TRIF-mediated programmed cell death", "MyD88 deficiency (TLR2/4)", "IRAK4 deficiency (TLR2/4)", "Regulation of TLR by endogenous ligand", "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon", "IKK complex recruitment mediated by RIP1", "TRAF6-mediated induction of TAK1 complex within TLR4 complex", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"], "71": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Gap junction degradation", "Formation of annular gap junctions", "Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "EPHB-mediated forward signaling", "EPH-ephrin mediated repulsion of cells", "Adherens junctions interactions", "Adherens junctions interactions", "Recycling pathway of L1", "Recycling pathway of L1", "VEGFA-VEGFR2 Pathway", "Interaction between L1 and Ankyrins", "Interaction between L1 and Ankyrins", "Cell-extracellular matrix interactions", "RHO GTPases activate IQGAPs", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate Formins", "RHO GTPases Activate Formins", "MAP2K and MAPK activation", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF", "Clathrin-mediated endocytosis"], "710": ["Platelet degranulation ", "Intrinsic Pathway of Fibrin Clot Formation", "Regulation of Complement cascade"], "7100": ["Toll Like Receptor 5 (TLR5) Cascade", "MyD88 deficiency (TLR5)", "IRAK4 deficiency (TLR5)", "MyD88 cascade initiated on plasma membrane"], "7101": ["Nuclear Receptor transcription pathway", "Regulation of PTEN gene transcription"], "7102": ["Cell surface interactions at the vascular wall", "Trafficking of GluR2-containing AMPA receptors"], "7108": ["Cholesterol biosynthesis", "Activation of gene expression by SREBF (SREBP)"], "7109": ["COPII-mediated vesicle transport", "RAB GEFs exchange GTP for GDP on RABs"], "7110": ["Retrograde transport at the Trans-Golgi-Network"], "7111": ["Striated Muscle Contraction"], "7112": ["Clearance of Nuclear Envelope Membranes from Chromatin", "Initiation of Nuclear Envelope Reformation", "Depolymerisation of the Nuclear Lamina"], "7114": ["Platelet degranulation "], "712": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Regulation of Complement cascade"], "7122": ["Tight junction interactions", "RUNX1 regulates expression of components of tight junctions"], "7123": ["Platelet degranulation "], "7124": ["Transcriptional regulation of white adipocyte differentiation", "TNFR1-induced proapoptotic signaling", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "TNFR1-mediated ceramide production", "TNFR2 non-canonical NF-kB pathway", "Interleukin-10 signaling", "Interleukin-4 and Interleukin-13 signaling", "TNF signaling"], "7125": ["Striated Muscle Contraction"], "7128": ["NOD1/2 Signaling Pathway", "TNFR1-induced proapoptotic signaling", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "Ovarian tumor domain proteases", "Negative regulators of DDX58/IFIH1 signaling"], "713": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Regulation of Complement cascade"], "7130": ["Neutrophil degranulation"], "7132": ["TNFR1-induced proapoptotic signaling", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "TNFR1-mediated ceramide production", "TNFs bind their physiological receptors", "Interleukin-10 signaling", "TNF signaling"], "7133": ["TNFR2 non-canonical NF-kB pathway", "TNFs bind their physiological receptors", "Interleukin-10 signaling", "Interleukin-4 and Interleukin-13 signaling", "Neutrophil degranulation"], "7134": ["Striated Muscle Contraction"], "7135": ["Striated Muscle Contraction"], "7136": ["Striated Muscle Contraction"], "7137": ["Striated Muscle Contraction", "Ion homeostasis"], "7138": ["Striated Muscle Contraction"], "7139": ["Striated Muscle Contraction"], "714": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Regulation of Complement cascade"], "7140": ["Striated Muscle Contraction"], "7143": ["ECM proteoglycans"], "7148": ["ECM proteoglycans"], "715": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Regulation of Complement cascade"], "7150": ["SUMOylation of DNA replication proteins"], "7153": ["Transcription of E2F targets under negative control by DREAM complex", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins"], "7155": ["SUMOylation of DNA replication proteins"], "7156": ["HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Regulation of TP53 Activity through Phosphorylation", "G2/M DNA damage checkpoint", "Meiotic recombination"], "7157": ["Activation of NOXA and translocation to mitochondria", "Activation of PUMA and translocation to mitochondria", "Pre-NOTCH Transcription and Translation", "Oxidative Stress Induced Senescence", "Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "Oncogene Induced Senescence", "DNA Damage/Telomere Stress Induced Senescence", "SUMOylation of transcription factors", "Autodegradation of the E3 ubiquitin ligase COP1", "Association of TriC/CCT with target proteins during biosynthesis", "TP53 Regulates Metabolic Genes", "Ub-specific processing proteases", "Ovarian tumor domain proteases", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Interleukin-4 and Interleukin-13 signaling", "TP53 Regulates Transcription of DNA Repair Genes", "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "TP53 Regulates Transcription of Caspase Activators and Caspases", "TP53 Regulates Transcription of Death Receptors and Ligands", "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "Regulation of TP53 Expression", "Regulation of TP53 Activity through Phosphorylation", "Regulation of TP53 Degradation", "Regulation of TP53 Activity through Acetylation", "Regulation of TP53 Activity through Association with Co-factors", "Regulation of TP53 Activity through Methylation", "PI5P Regulates TP53 Acetylation", "G2/M DNA damage checkpoint", "G2/M Checkpoints", "Stabilization of p53", "Transcriptional activation of cell cycle inhibitor p21 ", "The role of GTSE1 in G2/M progression after G2 checkpoint", "RUNX3 regulates CDKN1A transcription", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription", "Factors involved in megakaryocyte development and platelet production"], "7158": ["SUMOylation of transcription factors", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "G2/M DNA damage checkpoint"], "7159": ["Activation of PUMA and translocation to mitochondria", "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "TP53 Regulates Transcription of Death Receptors and Ligands", "Regulation of TP53 Activity through Association with Co-factors"], "716": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Regulation of Complement cascade"], "7161": ["Activation of PUMA and translocation to mitochondria", "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "TP53 Regulates Transcription of Caspase Activators and Caspases", "TP53 Regulates Transcription of Death Receptors and Ligands", "Regulation of TP53 Activity through Association with Co-factors", "RUNX1 regulates transcription of genes involved in differentiation of HSCs"], "7163": ["Golgi Associated Vesicle Biogenesis"], "7164": ["Golgi Associated Vesicle Biogenesis"], "7166": ["Serotonin and melatonin biosynthesis"], "7167": ["Glycolysis", "Gluconeogenesis"], "7168": ["Striated Muscle Contraction", "Smooth Muscle Contraction"], "7169": ["Striated Muscle Contraction", "Smooth Muscle Contraction"], "717": ["Initial triggering of complement", "Activation of C3 and C5", "Regulation of Complement cascade"], "7170": ["Striated Muscle Contraction", "Smooth Muscle Contraction"], "7171": ["Striated Muscle Contraction", "Smooth Muscle Contraction"], "7172": ["Methylation", "Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency)"], "7173": ["Thyroxine biosynthesis"], "7174": ["Antigen processing: Ubiquitination & Proteasome degradation"], "7175": ["ISG15 antiviral mechanism", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)", "tRNA processing in the nucleus"], "7177": ["Activation of Matrix Metalloproteinases"], "7179": ["Synthesis of PIPs at the Golgi membrane"], "718": ["Alternative complement activation", "Activation of C3 and C5", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Peptide ligand-binding receptors", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "G alpha (i) signalling events", "Neutrophil degranulation", "Post-translational protein phosphorylation", "Regulation of Complement cascade"], "7181": ["Nuclear Receptor transcription pathway", "SUMOylation of intracellular receptors"], "7182": ["Nuclear Receptor transcription pathway"], "7184": ["Trafficking and processing of endosomal TLR", "Scavenging by Class A Receptors", "Scavenging by Class A Receptors", "ATF6 (ATF6-alpha) activates chaperone genes", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Interleukin-4 and Interleukin-13 signaling", "Post-translational protein phosphorylation"], "7185": ["Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway"], "7186": ["Caspase activation via Death Receptors in the presence of ligand", "Regulation by c-FLIP", "RIPK1-mediated regulated necrosis", "CASP8 activity is inhibited", "TNFR1-induced proapoptotic signaling", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "TNFR2 non-canonical NF-kB pathway", "Regulation of necroptotic cell death", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "Ub-specific processing proteases", "Dimerization of procaspase-8", "TNF signaling", "TRAF6 mediated IRF7 activation", "TRAF6 mediated NF-kB activation", "TRAF6 mediated NF-kB activation"], "7187": ["TRAF3 deficiency - HSE", "TNFR2 non-canonical NF-kB pathway", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "Ovarian tumor domain proteases", "TICAM1-dependent activation of IRF3/IRF7", "TRAF3-dependent IRF activation pathway", "Negative regulators of DDX58/IFIH1 signaling", "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon"], "7189": ["PIP3 activates AKT signaling", "MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "NOD1/2 Signaling Pathway", "TICAM1, RIP1-mediated IKK complex recruitment ", "Regulated proteolysis of p75NTR", "Downstream TCR signaling", "NRIF signals cell death from the nucleus", "NRIF signals cell death from the nucleus", "p75NTR recruits signalling complexes", "NF-kB is activated and signals survival", "FCERI mediated NF-kB activation", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "activated TAK1 mediates p38 MAPK activation", "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "CLEC7A (Dectin-1) signaling", "Ub-specific processing proteases", "Ovarian tumor domain proteases", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "TICAM1,TRAF6-dependent induction of TAK1 complex", "Interleukin-1 signaling", "TRAF6 mediated IRF7 activation", "TRAF6 mediated NF-kB activation", "TRAF6 mediated NF-kB activation", "IRAK1 recruits IKK complex", "IKK complex recruitment mediated by RIP1", "IRAK2 mediated activation of TAK1 complex", "TRAF6-mediated induction of TAK1 complex within TLR4 complex", "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "MyD88 dependent cascade initiated on endosome", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "MyD88 cascade initiated on plasma membrane"], "719": ["Peptide ligand-binding receptors", "G alpha (i) signalling events", "Neutrophil degranulation", "Regulation of Complement cascade"], "72": ["Smooth Muscle Contraction"], "720": ["Initial triggering of complement", "Activation of C3 and C5", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation", "Regulation of Complement cascade"], "7200": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "7201": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "7203": ["Prefoldin mediated transfer of substrate to CCT/TriC", "Formation of tubulin folding intermediates by CCT/TriC", "Folding of actin by CCT/TriC", "Association of TriC/CCT with target proteins during biosynthesis", "Association of TriC/CCT with target proteins during biosynthesis", "BBSome-mediated cargo-targeting to cilium", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "7204": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "DCC mediated attractive signaling", "DCC mediated attractive signaling"], "721": ["Initial triggering of complement", "Activation of C3 and C5", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation", "Regulation of Complement cascade"], "722": ["Regulation of Complement cascade"], "7220": ["TRP channels", "Role of second messengers in netrin-1 signaling", "Ion homeostasis", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "7222": ["Effects of PIP2 hydrolysis", "Elevation of cytosolic Ca2+ levels", "TRP channels", "Role of second messengers in netrin-1 signaling", "MECP2 regulates neuronal receptors and channels"], "7223": ["TRP channels", "Role of second messengers in netrin-1 signaling"], "7224": ["TRP channels", "Role of second messengers in netrin-1 signaling"], "7225": ["Effects of PIP2 hydrolysis", "Elevation of cytosolic Ca2+ levels", "TRP channels", "Role of second messengers in netrin-1 signaling"], "7226": ["TRP channels", "Neutrophil degranulation"], "723790": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "HATs acetylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "UCH proteinases", "Ub-specific processing proteases", "Metalloprotease DUBs", "Deposition of new CENPA-containing nucleosomes at the centromere", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "7247": ["Small interfering RNA (siRNA) biogenesis"], "7248": ["Macroautophagy", "Inhibition of TSC complex formation by PKB", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "TBC/RABGAPs"], "7249": ["Macroautophagy", "Inhibition of TSC complex formation by PKB", "AKT phosphorylates targets in the cytosol", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Constitutive Signaling by AKT1 E17K in Cancer", "TBC/RABGAPs"], "725": ["Regulation of Complement cascade"], "7251": ["Budding and maturation of HIV virion", "Membrane binding and targetting of GAG proteins", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "7252": ["Glycoprotein hormones", "Thyroxine biosynthesis", "Hormone ligand-binding receptors", "G alpha (s) signalling events"], "7253": ["Hormone ligand-binding receptors", "G alpha (s) signalling events"], "7257": ["Small interfering RNA (siRNA) biogenesis"], "726": ["Degradation of the extracellular matrix"], "7263": ["Sulfide oxidation to sulfate", "Degradation of cysteine and homocysteine"], "7264": ["GDP-fucose biosynthesis"], "7266": ["Regulation of HSF1-mediated heat shock response"], "727": ["Terminal pathway of complement", "Activation of C3 and C5", "Peptide ligand-binding receptors", "G alpha (i) signalling events", "Regulation of Complement cascade"], "7270": ["ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "Surfactant metabolism", "Defective pro-SFTPB causes pulmonary surfactant metabolism dysfunction 1 (SMDP1) and respiratory distress syndrome (RDS)", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Transcription Termination", "RNA Polymerase I Transcription Termination"], "7273": ["Platelet degranulation ", "Striated Muscle Contraction"], "7274": ["Vitamin E"], "7276": ["Retinoid cycle disease events", "The canonical retinoid cycle in rods (twilight vision)", "Non-integrin membrane-ECM interactions", "Neutrophil degranulation", "Retinoid metabolism and transport", "Amyloid fiber formation"], "7277": ["Platelet degranulation ", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "Gap junction assembly", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Regulation of PLK1 Activity at G2/M Transition", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Prefoldin mediated transfer of substrate to CCT/TriC", "Formation of tubulin folding intermediates by CCT/TriC", "Post-chaperonin tubulin folding pathway", "Recycling pathway of L1", "Recycling pathway of L1", "Hedgehog 'off' state", "Cilium Assembly", "Anchoring of the basal body to the plasma membrane", "Intraflagellar transport", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "AURKA Activation by TPX2", "Carboxyterminal post-translational modifications of tubulin", "Carboxyterminal post-translational modifications of tubulin", "Activation of AMPK downstream of NMDARs", "Kinesins"], "7278": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "Gap junction assembly", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Recruitment of NuMA to mitotic centrosomes", "Prefoldin mediated transfer of substrate to CCT/TriC", "Formation of tubulin folding intermediates by CCT/TriC", "Post-chaperonin tubulin folding pathway", "Recycling pathway of L1", "Recycling pathway of L1", "Hedgehog 'off' state", "Cilium Assembly", "Intraflagellar transport", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "Carboxyterminal post-translational modifications of tubulin", "Carboxyterminal post-translational modifications of tubulin", "Activation of AMPK downstream of NMDARs", "Kinesins"], "727897": ["Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)", "Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)", "Defective GALNT12 causes colorectal cancer 1 (CRCS1)", "Dectin-2 family", "O-linked glycosylation of mucins", "Termination of O-glycan biosynthesis"], "728": ["Peptide ligand-binding receptors", "G alpha (i) signalling events", "Neutrophil degranulation", "Regulation of Complement cascade"], "7280": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "Gap junction assembly", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Recruitment of NuMA to mitotic centrosomes", "Prefoldin mediated transfer of substrate to CCT/TriC", "Formation of tubulin folding intermediates by CCT/TriC", "Post-chaperonin tubulin folding pathway", "Recycling pathway of L1", "Recycling pathway of L1", "Hedgehog 'off' state", "Cilium Assembly", "Intraflagellar transport", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "Carboxyterminal post-translational modifications of tubulin", "Carboxyterminal post-translational modifications of tubulin", "Activation of AMPK downstream of NMDARs", "Kinesins"], "728224": ["Keratinization"], "728255": ["Keratinization"], "728279": ["Keratinization"], "728294": ["Interconversion of 2-oxoglutarate and 2-hydroxyglutarate"], "728299": ["Keratinization"], "7283": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "728318": ["Keratinization"], "728343": ["Transport of Mature mRNA derived from an Intron-Containing Transcript"], "728358": ["Defensins", "Alpha-defensins", "Neutrophil degranulation"], "728369": ["Ub-specific processing proteases"], "728373": ["Ub-specific processing proteases"], "728379": ["Ub-specific processing proteases"], "728386": ["Ub-specific processing proteases"], "728393": ["Ub-specific processing proteases"], "7284": ["Mitochondrial translation elongation"], "728400": ["Ub-specific processing proteases"], "728405": ["Ub-specific processing proteases"], "728419": ["Ub-specific processing proteases"], "728458": ["The retinoid cycle in cones (daylight vision)", "Retinoid cycle disease events", "G alpha (i) signalling events", "Opsins"], "728642": ["Recruitment of mitotic centrosome proteins and complexes"], "7289": ["Hedgehog 'off' state"], "728927": ["Generic Transcription Pathway"], "728929": ["Formation of RNA Pol II elongation complex ", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "RNA Polymerase II Transcription Elongation"], "728957": ["Generic Transcription Pathway"], "729": ["Terminal pathway of complement", "Regulation of Complement cascade"], "7290": ["Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "729020": ["Pentose phosphate pathway"], "7291": ["Interleukin-4 and Interleukin-13 signaling", "Transcriptional regulation by RUNX2", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity"], "7292": ["TNFs bind their physiological receptors"], "729230": ["Beta defensins", "Chemokine receptors bind chemokines", "G alpha (i) signalling events", "Interleukin-10 signaling"], "729238": ["Toll Like Receptor 4 (TLR4) Cascade", "Toll Like Receptor TLR1:TLR2 Cascade", "Signal regulatory protein family interactions", "Surfactant metabolism", "Regulation of TLR by endogenous ligand", "Defective SFTPA2 causes idiopathic pulmonary fibrosis (IPF)", "Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5)", "Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)"], "7293": ["TNFs bind their physiological receptors"], "7294": ["FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization"], "7295": ["Oxidative Stress Induced Senescence", "Detoxification of Reactive Oxygen Species", "Interconversion of nucleotide di- and triphosphates", "TP53 Regulates Metabolic Genes", "Protein repair", "The NLRP3 inflammasome", "The NLRP3 inflammasome", "Regulation of FOXO transcriptional activity by acetylation"], "7296": ["PPARA activates gene expression", "Metabolism of ingested H2SeO4 and H2SeO3 into H2Se", "Detoxification of Reactive Oxygen Species", "Interconversion of nucleotide di- and triphosphates", "Metabolism of ingested MeSeO2H into MeSeH", "Uptake and function of diphtheria toxin", "TP53 Regulates Metabolic Genes"], "7297": ["Interleukin-6 signaling", "Interleukin-6 signaling", "MAPK3 (ERK1) activation", "MAPK1 (ERK2) activation", "Other interleukin signaling", "Interleukin-10 signaling", "Interleukin-4 and Interleukin-13 signaling", "IL-6-type cytokine receptor ligand interactions", "Interleukin-20 family signaling", "Interleukin-35 Signalling", "Interleukin-12 signaling", "Interleukin-12 signaling", "Interleukin-23 signaling", "Interleukin-23 signaling", "Interleukin-27 signaling", "Interleukin-27 signaling", "Interferon alpha/beta signaling", "Regulation of IFNA signaling", "Regulation of IFNA signaling"], "729759": ["Olfactory Signaling Pathway"], "7298": ["Interconversion of nucleotide di- and triphosphates", "Activation of E2F1 target genes at G1/S"], "729873": ["TBC/RABGAPs"], "7299": ["Melanin biosynthesis"], "730": ["Terminal pathway of complement", "Regulation of Complement cascade"], "730087": ["Generic Transcription Pathway"], "730291": ["Generic Transcription Pathway"], "7305": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "DAP12 interactions", "DAP12 interactions", "DAP12 signaling", "DAP12 signaling", "Signal regulatory protein family interactions", "Other semaphorin interactions", "Neutrophil degranulation"], "7306": ["Melanin biosynthesis"], "7307": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing"], "730755": ["Keratinization"], "731": ["Terminal pathway of complement", "Regulation of Complement cascade"], "7311": ["Translesion synthesis by REV1", "Recognition of DNA damage by PCNA-containing replication complex", "Translesion Synthesis by POLH", "Activation of NF-kappaB in B cells", "ISG15 antiviral mechanism", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "ER-Phagosome pathway", "Downregulation of ERBB4 signaling", "Spry regulation of FGF signaling", "Downregulation of ERBB2:ERBB3 signaling", "L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "Budding and maturation of HIV virion", "NOD1/2 Signaling Pathway", "TICAM1, RIP1-mediated IKK complex recruitment ", "DDX58/IFIH1-mediated induction of interferon-alpha/beta", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Membrane binding and targetting of GAG proteins", "Assembly Of The HIV Virion", "APC-Cdc20 mediated degradation of Nek2A", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "EGFR downregulation", "SCF(Skp2)-mediated degradation of p27/p21", "Viral mRNA Translation", "Degradation of beta-catenin by the destruction complex", "TCF dependent signaling in response to WNT", "Downstream TCR signaling", "NRIF signals cell death from the nucleus", "p75NTR recruits signalling complexes", "NF-kB is activated and signals survival", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "NOTCH1 Intracellular Domain Regulates Transcription", "Activated NOTCH1 Transmits Signal to the Nucleus", "Activated NOTCH1 Transmits Signal to the Nucleus", "Downregulation of TGF-beta receptor signaling", "Downregulation of TGF-beta receptor signaling", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Selenocysteine synthesis", "Separation of Sister Chromatids", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "Oncogene Induced Senescence", "Regulation of PLK1 Activity at G2/M Transition", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Stimuli-sensing channels", "Constitutive Signaling by NOTCH1 HD Domain Mutants", "FCERI mediated NF-kB activation", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "NOTCH2 Activation and Transmission of Signal to the Nucleus", "Regulation of innate immune responses to cytosolic DNA", "Glycogen synthesis", "Autodegradation of the E3 ubiquitin ligase COP1", "Deactivation of the beta-catenin transactivating complex", "Myoclonic epilepsy of Lafora", "ABC-family proteins mediated transport", "Circadian Clock", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "activated TAK1 mediates p38 MAPK activation", "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Regulation of FZD by ubiquitination", "Pink/Parkin Mediated Mitophagy", "N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Hedgehog 'on' state", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "Translesion synthesis by POLK", "Translesion synthesis by POLI", "Termination of translesion DNA synthesis", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "Negative regulation of MAPK pathway", "Regulation of necroptotic cell death", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAP3K8 (TPL2)-dependent MAPK1/3 activation", "HDR through Homologous Recombination (HRR)", "MAPK6/MAPK4 signaling", "UCH proteinases", "UCH proteinases", "Josephin domain DUBs", "Ub-specific processing proteases", "Ovarian tumor domain proteases", "Metalloprotease DUBs", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Processing of DNA double-strand break ends", "DNA Damage Recognition in GG-NER", "Formation of Incision Complex in GG-NER", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Fanconi Anemia Pathway", "Major pathway of rRNA processing in the nucleolus and cytosol", "Regulation of TP53 Activity through Phosphorylation", "Regulation of TP53 Degradation", "Regulation of TP53 Activity through Methylation", "Negative regulation of MET activity", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "Cyclin D associated events in G1", "G2/M Checkpoints", "Stabilization of p53", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "Downregulation of ERBB2 signaling", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "E3 ubiquitin ligases ubiquitinate target proteins", "InlB-mediated entry of Listeria monocytogenes into host cell", "InlA-mediated entry of Listeria monocytogenes into host cells", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN localization", "Regulation of PTEN stability and activity", "Neddylation", "ER Quality Control Compartment (ERQC)", "Regulation of expression of SLITs and ROBOs", "Regulation of expression of SLITs and ROBOs", "NOTCH3 Activation and Transmission of Signal to the Nucleus", "NOTCH3 Activation and Transmission of Signal to the Nucleus", "TICAM1-dependent activation of IRF3/IRF7", "TICAM1,TRAF6-dependent induction of TAK1 complex", "Interleukin-1 signaling", "Peroxisomal protein import", "Peroxisomal protein import", "Regulation of signaling by CBL", "Endosomal Sorting Complex Required For Transport (ESCRT)", "Iron uptake and transport", "Negative regulators of DDX58/IFIH1 signaling", "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon", "IRAK1 recruits IKK complex", "IKK complex recruitment mediated by RIP1", "IRAK2 mediated activation of TAK1 complex", "TRAF6-mediated induction of TAK1 complex within TLR4 complex", "Negative regulation of NOTCH4 signaling", "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "Amyloid fiber formation", "Antigen processing: Ubiquitination & Proteasome degradation"], "7314": ["Translesion synthesis by REV1", "Recognition of DNA damage by PCNA-containing replication complex", "Translesion Synthesis by POLH", "Activation of NF-kappaB in B cells", "ISG15 antiviral mechanism", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "ER-Phagosome pathway", "Downregulation of ERBB4 signaling", "Spry regulation of FGF signaling", "Downregulation of ERBB2:ERBB3 signaling", "Budding and maturation of HIV virion", "NOD1/2 Signaling Pathway", "TICAM1, RIP1-mediated IKK complex recruitment ", "DDX58/IFIH1-mediated induction of interferon-alpha/beta", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Membrane binding and targetting of GAG proteins", "Assembly Of The HIV Virion", "APC-Cdc20 mediated degradation of Nek2A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "EGFR downregulation", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "TCF dependent signaling in response to WNT", "Downstream TCR signaling", "NRIF signals cell death from the nucleus", "p75NTR recruits signalling complexes", "NF-kB is activated and signals survival", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "NOTCH1 Intracellular Domain Regulates Transcription", "Activated NOTCH1 Transmits Signal to the Nucleus", "Activated NOTCH1 Transmits Signal to the Nucleus", "Downregulation of TGF-beta receptor signaling", "Downregulation of TGF-beta receptor signaling", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Separation of Sister Chromatids", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "Oncogene Induced Senescence", "Regulation of PLK1 Activity at G2/M Transition", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Stimuli-sensing channels", "Constitutive Signaling by NOTCH1 HD Domain Mutants", "FCERI mediated NF-kB activation", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "NOTCH2 Activation and Transmission of Signal to the Nucleus", "Regulation of innate immune responses to cytosolic DNA", "Glycogen synthesis", "Autodegradation of the E3 ubiquitin ligase COP1", "Deactivation of the beta-catenin transactivating complex", "Myoclonic epilepsy of Lafora", "ABC-family proteins mediated transport", "Circadian Clock", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "activated TAK1 mediates p38 MAPK activation", "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Regulation of FZD by ubiquitination", "Pink/Parkin Mediated Mitophagy", "N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Hedgehog 'on' state", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "Translesion synthesis by POLK", "Translesion synthesis by POLI", "Termination of translesion DNA synthesis", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "Negative regulation of MAPK pathway", "Regulation of necroptotic cell death", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAP3K8 (TPL2)-dependent MAPK1/3 activation", "HDR through Homologous Recombination (HRR)", "MAPK6/MAPK4 signaling", "UCH proteinases", "UCH proteinases", "Josephin domain DUBs", "Ub-specific processing proteases", "Ovarian tumor domain proteases", "Metalloprotease DUBs", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Processing of DNA double-strand break ends", "DNA Damage Recognition in GG-NER", "Formation of Incision Complex in GG-NER", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Fanconi Anemia Pathway", "Regulation of TP53 Activity through Phosphorylation", "Regulation of TP53 Degradation", "Regulation of TP53 Activity through Methylation", "Negative regulation of MET activity", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "Cyclin D associated events in G1", "G2/M Checkpoints", "Stabilization of p53", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "Downregulation of ERBB2 signaling", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "E3 ubiquitin ligases ubiquitinate target proteins", "InlB-mediated entry of Listeria monocytogenes into host cell", "InlA-mediated entry of Listeria monocytogenes into host cells", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN localization", "Regulation of PTEN stability and activity", "Neddylation", "ER Quality Control Compartment (ERQC)", "Regulation of expression of SLITs and ROBOs", "Regulation of expression of SLITs and ROBOs", "NOTCH3 Activation and Transmission of Signal to the Nucleus", "NOTCH3 Activation and Transmission of Signal to the Nucleus", "TICAM1-dependent activation of IRF3/IRF7", "TICAM1,TRAF6-dependent induction of TAK1 complex", "Interleukin-1 signaling", "Peroxisomal protein import", "Peroxisomal protein import", "Regulation of signaling by CBL", "Endosomal Sorting Complex Required For Transport (ESCRT)", "Iron uptake and transport", "Negative regulators of DDX58/IFIH1 signaling", "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon", "IRAK1 recruits IKK complex", "IKK complex recruitment mediated by RIP1", "IRAK2 mediated activation of TAK1 complex", "TRAF6-mediated induction of TAK1 complex within TLR4 complex", "Negative regulation of NOTCH4 signaling", "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "Amyloid fiber formation", "Antigen processing: Ubiquitination & Proteasome degradation"], "7316": ["Translesion synthesis by REV1", "Recognition of DNA damage by PCNA-containing replication complex", "Translesion Synthesis by POLH", "Activation of NF-kappaB in B cells", "ISG15 antiviral mechanism", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "ER-Phagosome pathway", "Downregulation of ERBB4 signaling", "Spry regulation of FGF signaling", "Downregulation of ERBB2:ERBB3 signaling", "Budding and maturation of HIV virion", "NOD1/2 Signaling Pathway", "TICAM1, RIP1-mediated IKK complex recruitment ", "DDX58/IFIH1-mediated induction of interferon-alpha/beta", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Membrane binding and targetting of GAG proteins", "Assembly Of The HIV Virion", "APC-Cdc20 mediated degradation of Nek2A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "EGFR downregulation", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "TCF dependent signaling in response to WNT", "Downstream TCR signaling", "NRIF signals cell death from the nucleus", "p75NTR recruits signalling complexes", "NF-kB is activated and signals survival", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "NOTCH1 Intracellular Domain Regulates Transcription", "Activated NOTCH1 Transmits Signal to the Nucleus", "Activated NOTCH1 Transmits Signal to the Nucleus", "Downregulation of TGF-beta receptor signaling", "Downregulation of TGF-beta receptor signaling", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Separation of Sister Chromatids", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "Oncogene Induced Senescence", "Regulation of PLK1 Activity at G2/M Transition", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Stimuli-sensing channels", "Constitutive Signaling by NOTCH1 HD Domain Mutants", "FCERI mediated NF-kB activation", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "NOTCH2 Activation and Transmission of Signal to the Nucleus", "Regulation of innate immune responses to cytosolic DNA", "Glycogen synthesis", "Autodegradation of the E3 ubiquitin ligase COP1", "Deactivation of the beta-catenin transactivating complex", "Myoclonic epilepsy of Lafora", "ABC-family proteins mediated transport", "Circadian Clock", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "activated TAK1 mediates p38 MAPK activation", "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Regulation of FZD by ubiquitination", "Pink/Parkin Mediated Mitophagy", "N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Hedgehog 'on' state", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "Translesion synthesis by POLK", "Translesion synthesis by POLI", "Termination of translesion DNA synthesis", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "Negative regulation of MAPK pathway", "Regulation of necroptotic cell death", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAP3K8 (TPL2)-dependent MAPK1/3 activation", "HDR through Homologous Recombination (HRR)", "MAPK6/MAPK4 signaling", "UCH proteinases", "UCH proteinases", "Josephin domain DUBs", "Ub-specific processing proteases", "Ovarian tumor domain proteases", "Metalloprotease DUBs", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Processing of DNA double-strand break ends", "DNA Damage Recognition in GG-NER", "Formation of Incision Complex in GG-NER", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Fanconi Anemia Pathway", "Regulation of TP53 Activity through Phosphorylation", "Regulation of TP53 Degradation", "Regulation of TP53 Activity through Methylation", "Negative regulation of MET activity", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "Cyclin D associated events in G1", "G2/M Checkpoints", "Stabilization of p53", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "Downregulation of ERBB2 signaling", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "E3 ubiquitin ligases ubiquitinate target proteins", "InlB-mediated entry of Listeria monocytogenes into host cell", "InlA-mediated entry of Listeria monocytogenes into host cells", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN localization", "Regulation of PTEN stability and activity", "Neddylation", "ER Quality Control Compartment (ERQC)", "Regulation of expression of SLITs and ROBOs", "Regulation of expression of SLITs and ROBOs", "NOTCH3 Activation and Transmission of Signal to the Nucleus", "NOTCH3 Activation and Transmission of Signal to the Nucleus", "TICAM1-dependent activation of IRF3/IRF7", "TICAM1,TRAF6-dependent induction of TAK1 complex", "Interleukin-1 signaling", "Peroxisomal protein import", "Peroxisomal protein import", "Regulation of signaling by CBL", "Endosomal Sorting Complex Required For Transport (ESCRT)", "Iron uptake and transport", "Negative regulators of DDX58/IFIH1 signaling", "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon", "IRAK1 recruits IKK complex", "IKK complex recruitment mediated by RIP1", "IRAK2 mediated activation of TAK1 complex", "TRAF6-mediated induction of TAK1 complex within TLR4 complex", "Negative regulation of NOTCH4 signaling", "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "Amyloid fiber formation", "Antigen processing: Ubiquitination & Proteasome degradation"], "7317": ["Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Antigen processing: Ubiquitination & Proteasome degradation"], "7318": ["ISG15 antiviral mechanism", "DDX58/IFIH1-mediated induction of interferon-alpha/beta", "Termination of translesion DNA synthesis", "Negative regulators of DDX58/IFIH1 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "7319": ["Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "E3 ubiquitin ligases ubiquitinate target proteins", "Antigen processing: Ubiquitination & Proteasome degradation"], "732": ["Terminal pathway of complement", "Regulation of Complement cascade"], "7320": ["Recognition of DNA damage by PCNA-containing replication complex", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "E3 ubiquitin ligases ubiquitinate target proteins", "Antigen processing: Ubiquitination & Proteasome degradation"], "7321": ["Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Inactivation of APC/C via direct inhibition of the APC/C complex", "TICAM1, RIP1-mediated IKK complex recruitment ", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Signaling by BMP", "Downstream TCR signaling", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "FCERI mediated NF-kB activation", "CLEC7A (Dectin-1) signaling", "Ovarian tumor domain proteases", "CDK-mediated phosphorylation and removal of Cdc6", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "E3 ubiquitin ligases ubiquitinate target proteins", "Neddylation", "Peroxisomal protein import", "Negative regulators of DDX58/IFIH1 signaling", "IKK complex recruitment mediated by RIP1", "Antigen processing: Ubiquitination & Proteasome degradation"], "7322": ["Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "TICAM1, RIP1-mediated IKK complex recruitment ", "Downstream TCR signaling", "FCERI mediated NF-kB activation", "CLEC7A (Dectin-1) signaling", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "E3 ubiquitin ligases ubiquitinate target proteins", "Neddylation", "Peroxisomal protein import", "Negative regulators of DDX58/IFIH1 signaling", "IKK complex recruitment mediated by RIP1", "Antigen processing: Ubiquitination & Proteasome degradation"], "7323": ["Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "TICAM1, RIP1-mediated IKK complex recruitment ", "Signaling by BMP", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "E3 ubiquitin ligases ubiquitinate target proteins", "Neddylation", "Peroxisomal protein import", "Negative regulators of DDX58/IFIH1 signaling", "IKK complex recruitment mediated by RIP1", "Antigen processing: Ubiquitination & Proteasome degradation"], "7324": ["ISG15 antiviral mechanism", "Inactivation of APC/C via direct inhibition of the APC/C complex", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "E3 ubiquitin ligases ubiquitinate target proteins", "Antigen processing: Ubiquitination & Proteasome degradation"], "7325": ["Antigen processing: Ubiquitination & Proteasome degradation"], "7326": ["Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Antigen processing: Ubiquitination & Proteasome degradation"], "7327": ["Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Antigen processing: Ubiquitination & Proteasome degradation"], "7328": ["Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Antigen processing: Ubiquitination & Proteasome degradation"], "7329": ["Meiotic synapsis", "Vitamin D (calciferol) metabolism", "SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of transcription factors", "SUMOylation of transcription factors", "SUMOylation of ubiquitinylation proteins", "SUMOylation of transcription cofactors", "SUMOylation of transcription cofactors", "SUMOylation of SUMOylation proteins", "SUMOylation of intracellular receptors", "SUMOylation of intracellular receptors", "SUMOylation of chromatin organization proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA methylation proteins", "SUMOylation of DNA methylation proteins", "SUMOylation of immune response proteins", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Processing of DNA double-strand break ends", "Formation of Incision Complex in GG-NER", "Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "Negative regulation of activity of TFAP2 (AP-2) family transcription factors"], "733": ["Terminal pathway of complement", "Regulation of Complement cascade"], "7332": ["Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "E3 ubiquitin ligases ubiquitinate target proteins", "Antigen processing: Ubiquitination & Proteasome degradation"], "7334": ["ISG15 antiviral mechanism", "NOD1/2 Signaling Pathway", "TICAM1, RIP1-mediated IKK complex recruitment ", "Downstream TCR signaling", "FCERI mediated NF-kB activation", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "activated TAK1 mediates p38 MAPK activation", "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "CLEC7A (Dectin-1) signaling", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "Formation of Incision Complex in GG-NER", "G2/M DNA damage checkpoint", "E3 ubiquitin ligases ubiquitinate target proteins", "Interleukin-1 signaling", "IRAK1 recruits IKK complex", "IKK complex recruitment mediated by RIP1", "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "Antigen processing: Ubiquitination & Proteasome degradation"], "7335": ["NOD1/2 Signaling Pathway", "TICAM1, RIP1-mediated IKK complex recruitment ", "Downstream TCR signaling", "FCERI mediated NF-kB activation", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "activated TAK1 mediates p38 MAPK activation", "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "CLEC7A (Dectin-1) signaling", "Interleukin-1 signaling", "IRAK1 recruits IKK complex", "IKK complex recruitment mediated by RIP1", "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "Antigen processing: Ubiquitination & Proteasome degradation"], "7336": ["Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "Formation of Incision Complex in GG-NER", "G2/M DNA damage checkpoint", "E3 ubiquitin ligases ubiquitinate target proteins", "Antigen processing: Ubiquitination & Proteasome degradation"], "7337": ["Antigen processing: Ubiquitination & Proteasome degradation"], "7341": ["SUMO is conjugated to E1 (UBA2:SAE1)", "SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "SUMO is proteolytically processed", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of transcription factors", "SUMOylation of transcription factors", "SUMOylation of ubiquitinylation proteins", "SUMOylation of transcription cofactors", "SUMOylation of transcription cofactors", "SUMOylation of SUMOylation proteins", "SUMOylation of intracellular receptors", "SUMOylation of intracellular receptors", "SUMOylation of chromatin organization proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA methylation proteins", "SUMOylation of DNA methylation proteins", "SUMOylation of immune response proteins", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "Formation of Incision Complex in GG-NER", "G2/M DNA damage checkpoint", "Regulation of IFNG signaling", "Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "Negative regulation of activity of TFAP2 (AP-2) family transcription factors"], "7343": ["NoRC negatively regulates rRNA expression", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase I Transcription Termination"], "7345": ["UCH proteinases"], "7347": ["UCH proteinases", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Neddylation"], "7349": ["Class B/2 (Secretin family receptors)", "Synthesis, secretion, and deacylation of Ghrelin"], "735": ["Terminal pathway of complement", "Regulation of Complement cascade"], "7350": ["The fatty acid cycling model", "The proton buffering model"], "7351": ["The fatty acid cycling model", "The proton buffering model"], "7352": ["The fatty acid cycling model", "The proton buffering model"], "7353": ["Translesion Synthesis by POLH", "Ub-specific processing proteases"], "7355": ["Defective SLC35A2 causes congenital disorder of glycosylation 2M (CDG2M)", "Transport of nucleotide sugars"], "7357": ["Glycosphingolipid metabolism"], "7358": ["Formation of the active cofactor, UDP-glucuronate"], "7360": ["Formation of the active cofactor, UDP-glucuronate", "Glycogen synthesis"], "7363": ["Glucuronidation"], "7364": ["Glucuronidation"], "7365": ["Glucuronidation"], "7366": ["Glucuronidation"], "7367": ["Glucuronidation"], "7368": ["Glycosphingolipid metabolism"], "7369": ["Asparagine N-linked glycosylation"], "7371": ["Pyrimidine salvage"], "7372": ["Pyrimidine biosynthesis"], "7373": ["Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Assembly of collagen fibrils and other multimeric structures", "Collagen chain trimerization"], "7374": ["Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "Cleavage of the damaged pyrimidine ", "Displacement of DNA glycosylase by APEX1"], "7375": ["TNFR1-induced proapoptotic signaling", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "Ub-specific processing proteases"], "7376": ["PPARA activates gene expression", "Nuclear Receptor transcription pathway", "SUMOylation of intracellular receptors", "VLDLR internalisation and degradation"], "7378": ["Pyrimidine salvage", "Pyrimidine catabolism"], "738": ["Retrograde transport at the Trans-Golgi-Network"], "7381": ["Respiratory electron transport"], "7384": ["Respiratory electron transport"], "7385": ["Respiratory electron transport"], "7386": ["Respiratory electron transport"], "7388": ["Respiratory electron transport"], "7389": ["Heme biosynthesis"], "7390": ["Heme biosynthesis"], "7391": ["Estrogen-dependent gene expression"], "7392": ["Estrogen-dependent gene expression"], "7398": ["Recognition of DNA damage by PCNA-containing replication complex", "Fanconi Anemia Pathway"], "740": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "7403": ["HDMs demethylate histones", "Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "7404": ["HDMs demethylate histones"], "7405": ["Macroautophagy"], "7407": ["Cytosolic tRNA aminoacylation"], "7408": ["Generation of second messenger molecules", "Signaling by ROBO receptors", "Signaling by ROBO receptors", "Cell-extracellular matrix interactions"], "7409": ["GPVI-mediated activation cascade", "GPVI-mediated activation cascade", "PIP3 activates AKT signaling", "Signaling by SCF-KIT", "NRAGE signals death through JNK", "Rho GTPase cycle", "Regulation of actin dynamics for phagocytic cup formation", "Constitutive Signaling by Aberrant PI3K in Cancer", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "CD28 dependent Vav1 pathway", "G alpha (12/13) signalling events", "VEGFA-VEGFR2 Pathway", "VEGFA-VEGFR2 Pathway", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "VEGFR2 mediated vascular permeability", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Erythropoietin activates RAS", "Erythropoietin activates RAS", "Regulation of signaling by CBL", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "7410": ["GPVI-mediated activation cascade", "GPVI-mediated activation cascade", "NRAGE signals death through JNK", "Rho GTPase cycle", "Regulation of actin dynamics for phagocytic cup formation", "DAP12 signaling", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "EPH-ephrin mediated repulsion of cells", "G alpha (12/13) signalling events", "VEGFA-VEGFR2 Pathway", "VEGFA-VEGFR2 Pathway", "Signal transduction by L1", "VEGFR2 mediated vascular permeability"], "7411": ["Prefoldin mediated transfer of substrate to CCT/TriC"], "7412": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Integrin cell surface interactions", "Interleukin-4 and Interleukin-13 signaling", "Interferon gamma signaling"], "7414": ["Platelet degranulation ", "Smooth Muscle Contraction", "MAP2K and MAPK activation", "Neutrophil degranulation", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF"], "7415": ["Translesion Synthesis by POLH", "HSF1 activation", "ABC-family proteins mediated transport", "N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Defective CFTR causes cystic fibrosis", "Josephin domain DUBs", "Ovarian tumor domain proteases", "Neutrophil degranulation", "E3 ubiquitin ligases ubiquitinate target proteins", "Protein methylation"], "7416": ["Mitochondrial protein import", "Pink/Parkin Mediated Mitophagy", "Ub-specific processing proteases", "Pyruvate metabolism", "Mitochondrial calcium ion transport"], "7417": ["Ub-specific processing proteases", "Mitochondrial calcium ion transport"], "7419": ["Ub-specific processing proteases", "Mitochondrial calcium ion transport"], "7421": ["Vitamin D (calciferol) metabolism", "Nuclear Receptor transcription pathway", "SUMOylation of intracellular receptors"], "7422": ["Platelet degranulation ", "Regulation of gene expression by Hypoxia-inducible Factor", "VEGF ligand-receptor interactions", "VEGF binds to VEGFR leading to receptor dimerization", "VEGFA-VEGFR2 Pathway", "VEGFA-VEGFR2 Pathway", "VEGFR2 mediated cell proliferation", "Interleukin-4 and Interleukin-13 signaling", "TFAP2 (AP-2) family regulates transcription of growth factors and their receptors"], "7423": ["Platelet degranulation ", "VEGF ligand-receptor interactions", "VEGF binds to VEGFR leading to receptor dimerization"], "7424": ["Platelet degranulation ", "VEGF ligand-receptor interactions", "VEGF binds to VEGFR leading to receptor dimerization"], "7425": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "7428": ["Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "SUMOylation of ubiquitinylation proteins", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "7430": ["Netrin-1 signaling", "Recycling pathway of L1", "Recycling pathway of L1"], "7431": ["Caspase-mediated cleavage of cytoskeletal proteins", "Striated Muscle Contraction", "Interleukin-4 and Interleukin-13 signaling"], "7432": ["G alpha (s) signalling events", "Glucagon-type ligand receptors"], "7433": ["G alpha (s) signalling events", "Glucagon-type ligand receptors"], "7434": ["G alpha (s) signalling events", "Glucagon-type ligand receptors"], "7436": ["Reelin signalling pathway", "VLDLR internalisation and degradation", "VLDL clearance"], "7439": ["Stimuli-sensing channels"], "7441": ["Cell surface interactions at the vascular wall"], "7442": ["TRP channels"], "7443": ["Clearance of Nuclear Envelope Membranes from Chromatin", "Initiation of Nuclear Envelope Reformation"], "7444": ["Clearance of Nuclear Envelope Membranes from Chromatin", "Initiation of Nuclear Envelope Reformation"], "7448": ["Molecules associated with elastic fibres", "Integrin cell surface interactions", "Syndecan interactions", "ECM proteoglycans", "ECM proteoglycans", "Regulation of Complement cascade"], "7450": ["Platelet degranulation ", "Intrinsic Pathway of Fibrin Clot Formation", "Integrin cell surface interactions", "Integrin alphaIIb beta3 signaling", "GRB2:SOS provides linkage to MAPK signaling for Integrins ", "p130Cas linkage to MAPK signaling for integrins", "GP1b-IX-V activation signalling", "MAP2K and MAPK activation", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF", "Platelet Adhesion to exposed collagen", "Platelet Aggregation (Plug Formation)"], "7453": ["Cytosolic tRNA aminoacylation"], "7454": ["Generation of second messenger molecules", "Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs"], "7456": ["Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs"], "7458": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "7462": ["Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization"], "7465": ["Polo-like kinase mediated events", "Cyclin E associated events during G1/S transition ", "Cyclin A/B1/B2 associated events during G2/M transition", "Cyclin A/B1/B2 associated events during G2/M transition", "G2/M DNA replication checkpoint", "Cyclin A:Cdk2-associated events at S phase entry", "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "Factors involved in megakaryocyte development and platelet production"], "7466": ["XBP1(S) activates chaperone genes", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "7468": ["PKMTs methylate histone lysines", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "G2/M DNA damage checkpoint"], "7469": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Abortive elongation of HIV-1 transcript in the absence of Tat", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "RNA Polymerase II Transcription Elongation"], "747": ["Arachidonate production from DAG"], "7471": ["TCF dependent signaling in response to WNT", "TCF dependent signaling in response to WNT", "WNT ligand biogenesis and trafficking", "WNT ligand biogenesis and trafficking", "Class B/2 (Secretin family receptors)", "Transcriptional regulation of white adipocyte differentiation", "PCP/CE pathway", "PCP/CE pathway", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Disassembly of the destruction complex and recruitment of AXIN to the membrane"], "7472": ["WNT ligand biogenesis and trafficking", "WNT ligand biogenesis and trafficking", "Class B/2 (Secretin family receptors)"], "7473": ["TCF dependent signaling in response to WNT", "WNT ligand biogenesis and trafficking", "WNT ligand biogenesis and trafficking", "Class B/2 (Secretin family receptors)"], "7474": ["TCF dependent signaling in response to WNT", "TCF dependent signaling in response to WNT", "WNT ligand biogenesis and trafficking", "WNT ligand biogenesis and trafficking", "Class B/2 (Secretin family receptors)", "Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "Ca2+ pathway", "Ca2+ pathway", "PCP/CE pathway", "PCP/CE pathway", "Asymmetric localization of PCP proteins", "WNT5A-dependent internalization of FZD4", "WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "7475": ["WNT ligand biogenesis and trafficking", "WNT ligand biogenesis and trafficking", "Class B/2 (Secretin family receptors)"], "7476": ["WNT ligand biogenesis and trafficking", "WNT ligand biogenesis and trafficking", "Class B/2 (Secretin family receptors)"], "7477": ["WNT ligand biogenesis and trafficking", "WNT ligand biogenesis and trafficking", "Class B/2 (Secretin family receptors)"], "7478": ["TCF dependent signaling in response to WNT", "WNT ligand biogenesis and trafficking", "WNT ligand biogenesis and trafficking", "Class B/2 (Secretin family receptors)", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Disassembly of the destruction complex and recruitment of AXIN to the membrane"], "7479": ["TCF dependent signaling in response to WNT", "WNT ligand biogenesis and trafficking", "WNT ligand biogenesis and trafficking", "Class B/2 (Secretin family receptors)", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Disassembly of the destruction complex and recruitment of AXIN to the membrane"], "7480": ["WNT ligand biogenesis and trafficking", "WNT ligand biogenesis and trafficking", "Class B/2 (Secretin family receptors)", "Transcriptional regulation of white adipocyte differentiation"], "7481": ["WNT ligand biogenesis and trafficking", "WNT ligand biogenesis and trafficking", "Class B/2 (Secretin family receptors)", "Ca2+ pathway", "Ca2+ pathway", "PCP/CE pathway", "PCP/CE pathway"], "7482": ["WNT ligand biogenesis and trafficking", "WNT ligand biogenesis and trafficking", "Class B/2 (Secretin family receptors)"], "7483": ["TCF dependent signaling in response to WNT", "WNT ligand biogenesis and trafficking", "WNT ligand biogenesis and trafficking", "Class B/2 (Secretin family receptors)", "Negative regulation of TCF-dependent signaling by WNT ligand antagonists"], "7484": ["WNT ligand biogenesis and trafficking", "WNT ligand biogenesis and trafficking", "Class B/2 (Secretin family receptors)"], "7486": ["SUMOylation of DNA damage response and repair proteins", "HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Regulation of TP53 Activity through Phosphorylation", "G2/M DNA damage checkpoint"], "7494": ["XBP1(S) activates chaperone genes", "IRE1alpha activates chaperones", "ATF6 (ATF6-alpha) activates chaperone genes"], "7498": ["Purine catabolism", "Butyrophilin (BTN) family interactions"], "7504": ["Peptide ligand-binding receptors"], "7507": ["Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER"], "7508": ["SUMOylation of DNA damage response and repair proteins", "DNA Damage Recognition in GG-NER", "Formation of Incision Complex in GG-NER"], "7512": ["Post-translational modification: synthesis of GPI-anchored proteins"], "7514": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Rev-mediated nuclear export of HIV RNA", "NEP/NS2 Interacts with the Cellular Export Machinery", "Downregulation of TGF-beta receptor signaling", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Deactivation of the beta-catenin transactivating complex", "HuR (ELAVL1) binds and stabilizes mRNA", "RHO GTPases Activate Formins", "MAPK6/MAPK4 signaling", "Mitotic Prometaphase", "Cyclin A/B1/B2 associated events during G2/M transition"], "7515": ["Resolution of AP sites via the single-nucleotide replacement pathway", "APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "HDR through MMEJ (alt-NHEJ)", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER"], "7516": ["HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange", "Presynaptic phase of homologous DNA pairing and strand exchange"], "7517": ["HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange"], "7518": ["2-LTR circle formation", "SUMOylation of DNA damage response and repair proteins", "Nonhomologous End-Joining (NHEJ)"], "752": ["RHO GTPases Activate Formins", "RHO GTPases Activate Formins"], "7520": ["2-LTR circle formation", "Cytosolic sensors of pathogen-associated DNA ", "IRF3-mediated induction of type I IFN", "Nonhomologous End-Joining (NHEJ)", "Neutrophil degranulation"], "7525": ["Signaling by ERBB2", "Signaling by SCF-KIT", "Signaling by SCF-KIT", "Regulation of KIT signaling", "FCGR activation", "PECAM1 interactions", "EPH-Ephrin signaling", "CD28 co-stimulation", "CTLA4 inhibitory signaling", "EPHB-mediated forward signaling", "EPHB-mediated forward signaling", "EPHA-mediated growth cone collapse", "EPHA-mediated growth cone collapse", "EPH-ephrin mediated repulsion of cells", "RUNX2 regulates osteoblast differentiation", "Regulation of signaling by CBL", "Regulation of signaling by CBL"], "7528": ["Activation of anterior HOX genes in hindbrain development during early embryogenesis", "UCH proteinases", "DNA Damage Recognition in GG-NER", "TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "Estrogen-dependent gene expression"], "7529": ["Activation of BAD and translocation to mitochondria ", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "mTOR signalling", "mTORC1-mediated signalling", "Frs2-mediated activation", "ARMS-mediated activation", "Signaling by Hippo", "Rap1 signalling", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "RHO GTPases activate PKNs", "TP53 Regulates Metabolic Genes", "RAF activation", "MAP2K and MAPK activation", "Negative regulation of MAPK pathway", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF", "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "Regulation of localization of FOXO transcription factors"], "7531": ["Activation of BAD and translocation to mitochondria ", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Signaling by Hippo", "NADE modulates death signalling", "Regulation of PLK1 Activity at G2/M Transition", "Regulation of HSF1-mediated heat shock response", "HSF1 activation", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "RHO GTPases activate PKNs", "TP53 Regulates Metabolic Genes", "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "AURKA Activation by TPX2", "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "RAB GEFs exchange GTP for GDP on RABs"], "7532": ["Activation of BAD and translocation to mitochondria ", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "RHO GTPases activate PKNs", "TP53 Regulates Metabolic Genes", "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "AURKA Activation by TPX2", "Regulation of localization of FOXO transcription factors"], "7533": ["Activation of BAD and translocation to mitochondria ", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "RHO GTPases activate PKNs", "TP53 Regulates Metabolic Genes", "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex"], "7534": ["Activation of BAD and translocation to mitochondria ", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Deactivation of the beta-catenin transactivating complex", "Rap1 signalling", "GP1b-IX-V activation signalling", "KSRP (KHSRP) binds and destabilizes mRNA", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "RHO GTPases activate PKNs", "TP53 Regulates Metabolic Genes", "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "NOTCH4 Activation and Transmission of Signal to the Nucleus", "Negative regulation of NOTCH4 signaling", "Regulation of localization of FOXO transcription factors"], "7535": ["Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules"], "7536": ["mRNA Splicing - Major Pathway"], "7538": ["Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA"], "7539": ["Generic Transcription Pathway"], "7547": ["POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation", "Transcriptional regulation of pluripotent stem cells"], "7549": ["Generic Transcription Pathway"], "7551": ["Generic Transcription Pathway"], "7552": ["Generic Transcription Pathway"], "7556": ["Generic Transcription Pathway"], "7559": ["Generic Transcription Pathway"], "7561": ["Generic Transcription Pathway"], "7562": ["Generic Transcription Pathway"], "7565": ["Generic Transcription Pathway"], "7566": ["Generic Transcription Pathway"], "7567": ["Generic Transcription Pathway"], "7568": ["Generic Transcription Pathway"], "7571": ["Generic Transcription Pathway"], "7574": ["Generic Transcription Pathway"], "7576": ["Generic Transcription Pathway"], "7581": ["Generic Transcription Pathway"], "7582": ["Generic Transcription Pathway"], "7586": ["Generic Transcription Pathway"], "7587": ["Generic Transcription Pathway"], "759": ["Erythrocytes take up carbon dioxide and release oxygen", "Erythrocytes take up oxygen and release carbon dioxide", "Reversible hydration of carbon dioxide", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "7592": ["Generic Transcription Pathway"], "7594": ["Generic Transcription Pathway"], "7596": ["Generic Transcription Pathway"], "760": ["Erythrocytes take up carbon dioxide and release oxygen", "Erythrocytes take up oxygen and release carbon dioxide", "Reversible hydration of carbon dioxide"], "761": ["Reversible hydration of carbon dioxide"], "762": ["Erythrocytes take up carbon dioxide and release oxygen", "Erythrocytes take up oxygen and release carbon dioxide", "Reversible hydration of carbon dioxide"], "7621": ["Generic Transcription Pathway"], "7625": ["Generic Transcription Pathway"], "7626": ["Generic Transcription Pathway"], "7627": ["Generic Transcription Pathway"], "763": ["Reversible hydration of carbon dioxide"], "7633": ["Generic Transcription Pathway"], "7638": ["Generic Transcription Pathway"], "765": ["Reversible hydration of carbon dioxide"], "7652": ["Generic Transcription Pathway"], "766": ["Reversible hydration of carbon dioxide"], "7673": ["Generic Transcription Pathway"], "7678": ["Generic Transcription Pathway"], "768": ["Regulation of gene expression by Hypoxia-inducible Factor", "Reversible hydration of carbon dioxide"], "7690": ["SUMOylation of transcription cofactors"], "7692": ["Generic Transcription Pathway"], "7694": ["Generic Transcription Pathway"], "7695": ["Generic Transcription Pathway"], "7697": ["Generic Transcription Pathway"], "7699": ["Generic Transcription Pathway"], "7700": ["Generic Transcription Pathway"], "7702": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "7703": ["SUMOylation of DNA damage response and repair proteins", "SUMOylation of transcription cofactors", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA methylation proteins", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Transcriptional Regulation by E2F6"], "7704": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "7706": ["ISG15 antiviral mechanism", "DDX58/IFIH1-mediated induction of interferon-alpha/beta", "Termination of translesion DNA synthesis", "Ovarian tumor domain proteases", "Interferon gamma signaling", "TRAF3-dependent IRF activation pathway", "TRAF6 mediated IRF7 activation", "TRAF6 mediated NF-kB activation", "TRAF6 mediated NF-kB activation", "NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10", "Negative regulators of DDX58/IFIH1 signaling", "Negative regulators of DDX58/IFIH1 signaling"], "7709": ["XBP1(S) activates chaperone genes"], "771": ["Reversible hydration of carbon dioxide"], "7710": ["Generic Transcription Pathway"], "7711": ["Generic Transcription Pathway"], "7712": ["Generic Transcription Pathway"], "7726": ["Interferon gamma signaling"], "7728": ["Generic Transcription Pathway"], "773": ["Presynaptic depolarization and calcium channel opening", "Regulation of insulin secretion"], "7733": ["Generic Transcription Pathway"], "7738": ["Generic Transcription Pathway"], "774": ["Presynaptic depolarization and calcium channel opening"], "7743": ["Generic Transcription Pathway"], "7745": ["Generic Transcription Pathway"], "7748": ["Generic Transcription Pathway"], "775": ["Adrenaline,noradrenaline inhibits insulin secretion", "NCAM1 interactions", "Regulation of insulin secretion", "Regulation of insulin secretion", "Phase 0 - rapid depolarisation", "Phase 2 - plateau phase"], "7750": ["Signaling by cytosolic FGFR1 fusion mutants", "Signaling by FGFR1 in disease"], "7752": ["Generic Transcription Pathway"], "7753": ["Generic Transcription Pathway"], "7755": ["Generic Transcription Pathway"], "7757": ["Generic Transcription Pathway"], "776": ["Adrenaline,noradrenaline inhibits insulin secretion", "NCAM1 interactions", "Regulation of insulin secretion", "Regulation of insulin secretion", "Phase 0 - rapid depolarisation", "Phase 2 - plateau phase"], "7760": ["Generic Transcription Pathway"], "7761": ["Generic Transcription Pathway"], "7762": ["Generic Transcription Pathway"], "7764": ["Estrogen-dependent gene expression"], "7766": ["Generic Transcription Pathway"], "7767": ["Generic Transcription Pathway"], "7768": ["Generic Transcription Pathway"], "7769": ["Generic Transcription Pathway"], "777": ["Presynaptic depolarization and calcium channel opening", "Regulation of insulin secretion"], "7770": ["Generic Transcription Pathway"], "7771": ["Generic Transcription Pathway"], "7773": ["Generic Transcription Pathway"], "7779": ["Zinc efflux and compartmentalization by the SLC30 family"], "778": ["Phase 0 - rapid depolarisation", "Phase 2 - plateau phase"], "7780": ["Zinc efflux and compartmentalization by the SLC30 family"], "7781": ["Zinc efflux and compartmentalization by the SLC30 family"], "7783": ["Interaction With The Zona Pellucida"], "7784": ["Interaction With The Zona Pellucida"], "779": ["NCAM1 interactions", "Phase 0 - rapid depolarisation", "Phase 2 - plateau phase"], "780": ["Non-integrin membrane-ECM interactions"], "7804": ["Platelet sensitization by LDL", "Retinoid metabolism and transport"], "7809": ["Stimuli-sensing channels"], "781": ["Presynaptic depolarization and calcium channel opening", "Phase 0 - rapid depolarisation", "Phase 2 - plateau phase"], "7818": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "782": ["Presynaptic depolarization and calcium channel opening", "NCAM1 interactions", "Phase 0 - rapid depolarisation", "Phase 2 - plateau phase"], "7827": ["Nephrin family interactions"], "783": ["Presynaptic depolarization and calcium channel opening", "Adrenaline,noradrenaline inhibits insulin secretion", "NCAM1 interactions", "Regulation of insulin secretion", "Regulation of insulin secretion", "Phase 0 - rapid depolarisation", "Phase 2 - plateau phase"], "7832": ["TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "7837": ["Crosslinking of collagen fibrils"], "784": ["Presynaptic depolarization and calcium channel opening", "Adrenaline,noradrenaline inhibits insulin secretion", "NCAM1 interactions", "Regulation of insulin secretion", "Regulation of insulin secretion", "Phase 0 - rapid depolarisation", "Phase 2 - plateau phase"], "7840": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "7841": ["Defective MOGS causes MOGS-CDG (CDG-2b)", "N-glycan trimming in the ER and Calnexin/Calreticulin cycle"], "7844": ["ER Quality Control Compartment (ERQC)"], "7846": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "Gap junction assembly", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Regulation of PLK1 Activity at G2/M Transition", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Prefoldin mediated transfer of substrate to CCT/TriC", "Formation of tubulin folding intermediates by CCT/TriC", "Post-chaperonin tubulin folding pathway", "Recycling pathway of L1", "Recycling pathway of L1", "Hedgehog 'off' state", "Cilium Assembly", "Anchoring of the basal body to the plasma membrane", "Intraflagellar transport", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "AURKA Activation by TPX2", "Carboxyterminal post-translational modifications of tubulin", "Carboxyterminal post-translational modifications of tubulin", "Activation of AMPK downstream of NMDARs", "Kinesins"], "785": ["Presynaptic depolarization and calcium channel opening", "NCAM1 interactions", "Phase 0 - rapid depolarisation", "Phase 2 - plateau phase"], "7850": ["Interleukin-10 signaling", "Interleukin-1 signaling"], "7852": ["Binding and entry of HIV virion", "Signaling by ROBO receptors", "Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "7855": ["Class B/2 (Secretin family receptors)", "Ca2+ pathway", "Ca2+ pathway", "Asymmetric localization of PCP proteins", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Regulation of FZD by ubiquitination", "WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "RNF mutants show enhanced WNT signaling and proliferation"], "7857": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "786": ["Phase 0 - rapid depolarisation", "Phase 2 - plateau phase"], "7862": ["HATs acetylate histones", "Regulation of TP53 Activity through Acetylation"], "7867": ["p38MAPK events", "Oxidative Stress Induced Senescence", "VEGFA-VEGFR2 Pathway", "activated TAK1 mediates p38 MAPK activation"], "7873": ["Platelet degranulation "], "7874": ["Ub-specific processing proteases", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Regulation of TP53 Degradation", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Regulation of PTEN localization"], "7879": ["MHC class II antigen presentation", "Neutrophil degranulation", "TBC/RABGAPs", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "788": ["Import of palmitoyl-CoA into the mitochondrial matrix"], "7881": ["Voltage gated Potassium channels"], "7884": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of the SLBP Dependant Mature mRNA", "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"], "78988": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "78989": ["Lectin pathway of complement activation", "Initial triggering of complement", "Scavenging by Class A Receptors"], "78990": ["Ovarian tumor domain proteases"], "78991": ["Platelet degranulation "], "78999": ["Synaptic adhesion-like molecules"], "790": ["Pyrimidine biosynthesis"], "79001": ["Metabolism of vitamin K"], "79003": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "79008": ["Resolution of D-loop Structures through Holliday Junction Intermediates", "Fanconi Anemia Pathway"], "79016": ["Neddylation"], "79017": ["Glutathione synthesis and recycling"], "79019": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Deposition of new CENPA-containing nucleosomes at the centromere", "Mitotic Prometaphase"], "79023": ["ISG15 antiviral mechanism", "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "RHO GTPases Activate Formins", "tRNA processing in the nucleus", "Mitotic Prometaphase"], "79027": ["Generic Transcription Pathway"], "7903": ["Sialic acid metabolism", "NCAM1 interactions"], "79035": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes"], "79042": ["tRNA processing in the nucleus"], "79047": ["Negative regulation of activity of TFAP2 (AP-2) family transcription factors"], "79048": ["Selenocysteine synthesis"], "7905": ["Olfactory Signaling Pathway"], "79050": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "79053": ["Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "Defective ALG8 causes ALG8-CDG (CDG-1h)"], "79054": ["TRP channels"], "79058": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane"], "79065": ["Macroautophagy"], "79068": ["Reversal of alkylation damage by DNA dioxygenases"], "79071": ["Activation of gene expression by SREBF (SREBP)", "Synthesis of very long-chain fatty acyl-CoAs"], "79074": ["tRNA processing in the nucleus"], "79077": ["Interconversion of nucleotide di- and triphosphates"], "79084": ["snRNP Assembly", "RMTs methylate histone arginines"], "79087": ["Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "Defective ALG12 causes ALG12-CDG (CDG-1g)"], "79088": ["Generic Transcription Pathway"], "79090": ["COPII-mediated vesicle transport", "RAB GEFs exchange GTP for GDP on RABs"], "79091": ["Protein methylation"], "79094": ["Glutathione synthesis and recycling"], "79097": ["Interferon gamma signaling"], "79101": ["SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase I Transcription Termination"], "79109": ["PIP3 activates AKT signaling", "CD28 dependent PI3K/Akt signaling", "VEGFR2 mediated vascular permeability", "Constitutive Signaling by AKT1 E17K in Cancer", "Regulation of TP53 Degradation"], "7913": ["B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors"], "79132": ["DDX58/IFIH1-mediated induction of interferon-alpha/beta"], "79133": ["Complex I biogenesis"], "79135": ["Cristae formation"], "79139": ["ABC-family proteins mediated transport", "N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "Defective CFTR causes cystic fibrosis", "E3 ubiquitin ligases ubiquitinate target proteins"], "79143": ["Acyl chain remodelling of PI"], "79145": ["Mitochondrial protein import"], "7915": ["Degradation of GABA"], "79152": ["Sphingolipid de novo biosynthesis"], "79153": ["Glycerophospholipid catabolism"], "79155": ["MAP3K8 (TPL2)-dependent MAPK1/3 activation", "Ovarian tumor domain proteases"], "79159": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "79169": ["Neutrophil degranulation"], "79172": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Deposition of new CENPA-containing nucleosomes at the centromere", "Mitotic Prometaphase"], "79175": ["Generic Transcription Pathway"], "79176": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "79178": ["Vitamin B1 (thiamin) metabolism"], "79184": ["Metalloprotease DUBs", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "G2/M DNA damage checkpoint"], "7919": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA 3'-end processing"], "7922": ["Zinc influx into cells by the SLC39 gene family"], "79228": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA 3'-end processing"], "7923": ["Fatty acyl-CoA biosynthesis"], "79230": ["Generic Transcription Pathway"], "79269": ["Neddylation"], "79290": ["Olfactory Signaling Pathway"], "79295": ["Olfactory Signaling Pathway"], "79296": ["Olfactory Signaling Pathway"], "793": ["Amyloid fiber formation"], "79310": ["Olfactory Signaling Pathway"], "79317": ["Olfactory Signaling Pathway"], "7932": ["Olfactory Signaling Pathway"], "79324": ["Olfactory Signaling Pathway"], "79334": ["Olfactory Signaling Pathway"], "79339": ["Olfactory Signaling Pathway"], "79345": ["Olfactory Signaling Pathway"], "79346": ["Olfactory Signaling Pathway"], "7936": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Abortive elongation of HIV-1 transcript in the absence of Tat", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "RNA Polymerase II Transcription Elongation"], "79365": ["BMAL1:CLOCK,NPAS2 activates circadian gene expression", "Circadian Clock"], "79369": ["Keratan sulfate biosynthesis", "O-linked glycosylation of mucins"], "79370": ["TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain"], "79400": ["Detoxification of Reactive Oxygen Species"], "7941": ["Synthesis, secretion, and deacylation of Ghrelin"], "79411": ["Glycosphingolipid metabolism", "Keratan sulfate degradation", "HS-GAG degradation"], "79412": ["TCF dependent signaling in response to WNT", "Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling"], "79414": ["Synaptic adhesion-like molecules"], "79441": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "79447": ["Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "79465": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "79470": ["Olfactory Signaling Pathway"], "79473": ["Olfactory Signaling Pathway"], "79501": ["Olfactory Signaling Pathway"], "79541": ["Olfactory Signaling Pathway"], "79544": ["Olfactory Signaling Pathway"], "79568": ["Processing of SMDT1"], "7957": ["Glycogen synthesis", "Myoclonic epilepsy of Lafora"], "79571": ["Retrograde transport at the Trans-Golgi-Network"], "79577": ["Formation of RNA Pol II elongation complex ", "Formation of the beta-catenin:TCF transactivating complex", "Hedgehog 'on' state", "RNA Polymerase II Pre-transcription Events", "RNA Polymerase II Transcription Elongation", "E3 ubiquitin ligases ubiquitinate target proteins"], "79581": ["Vitamin B2 (riboflavin) metabolism"], "79586": ["Chondroitin sulfate biosynthesis"], "79587": ["Mitochondrial tRNA aminoacylation"], "79589": ["Ub-specific processing proteases", "Ovarian tumor domain proteases"], "79590": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "79594": ["Ub-specific processing proteases"], "79595": ["HATs acetylate histones", "NoRC negatively regulates rRNA expression"], "79598": ["Anchoring of the basal body to the plasma membrane"], "796": ["G alpha (s) signalling events", "Calcitonin-like ligand receptors", "Amyloid fiber formation"], "79600": ["Anchoring of the basal body to the plasma membrane"], "79602": ["AMPK inhibits chREBP transcriptional activation activity", "AMPK inhibits chREBP transcriptional activation activity"], "79603": ["Sphingolipid de novo biosynthesis"], "79609": ["Protein methylation"], "79611": ["Synthesis of Ketone Bodies"], "79622": ["mRNA Splicing - Minor Pathway"], "79623": ["O-linked glycosylation of mucins"], "79626": ["PI Metabolism"], "79642": ["Glycosphingolipid metabolism", "The activation of arylsulfatases"], "79643": ["Budding and maturation of HIV virion", "Macroautophagy", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "79644": ["Androgen biosynthesis", "Synthesis of Dolichyl-phosphate", "Defective SRD5A3 causes SRD5A3-CDG (CDG-1q) and KHRZ"], "79646": ["Coenzyme A biosynthesis"], "79648": ["Condensation of Prophase Chromosomes"], "7965": ["SeMet incorporation into proteins", "Cytosolic tRNA aminoacylation"], "79654": ["Antigen processing: Ubiquitination & Proteasome degradation"], "79658": ["Rho GTPase cycle", "Regulation of PAK-2p34 activity by PS-GAP/RHG10"], "79659": ["Hedgehog 'off' state", "Intraflagellar transport"], "79661": ["Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "Cleavage of the damaged pyrimidine ", "APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway"], "79664": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes"], "79668": ["Nicotinamide salvaging"], "79670": ["Deadenylation of mRNA"], "79671": ["DDX58/IFIH1-mediated induction of interferon-alpha/beta", "Negative regulators of DDX58/IFIH1 signaling"], "79672": ["Gamma carboxylation, hypusine formation and arylsulfatase activation"], "79677": ["SUMOylation of DNA damage response and repair proteins"], "79682": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Deposition of new CENPA-containing nucleosomes at the centromere", "Mitotic Prometaphase"], "79685": ["HDACs deacetylate histones", "NoRC negatively regulates rRNA expression"], "79691": ["tRNA modification in the nucleus and cytosol"], "79694": ["N-glycan trimming and elongation in the cis-Golgi"], "79695": ["Defective GALNT12 causes colorectal cancer 1 (CRCS1)", "O-linked glycosylation of mucins"], "797": ["G alpha (s) signalling events", "Calcitonin-like ligand receptors"], "79707": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "79709": ["Collagen biosynthesis and modifying enzymes"], "79717": ["Coenzyme A biosynthesis"], "79718": ["RORA activates gene expression", "BMAL1:CLOCK,NPAS2 activates circadian gene expression", "PPARA activates gene expression", "PPARA activates gene expression", "NOTCH1 Intracellular Domain Regulates Transcription", "Transcriptional activation of mitochondrial biogenesis", "Activation of gene expression by SREBF (SREBP)", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "HDACs deacetylate histones", "Transcriptional regulation of white adipocyte differentiation", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)", "Circadian Clock", "Loss of MECP2 binding ability to the NCoR/SMRT complex", "Regulation of MECP2 expression and activity"], "79720": ["Budding and maturation of HIV virion", "Membrane binding and targetting of GAG proteins", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "79723": ["PKMTs methylate histone lysines"], "79727": ["Transcriptional regulation of pluripotent stem cells"], "79728": ["HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange"], "79731": ["Mitochondrial tRNA aminoacylation"], "79733": ["TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest"], "79735": ["TBC/RABGAPs"], "79738": ["BBSome-mediated cargo-targeting to cilium"], "79739": ["Carboxyterminal post-translational modifications of tubulin"], "79744": ["Generic Transcription Pathway"], "79748": ["COPII-mediated vesicle transport", "Cargo concentration in the ER"], "7975": ["Factors involved in megakaryocyte development and platelet production", "Factors involved in megakaryocyte development and platelet production"], "79751": ["Organic anion transporters"], "79754": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "79755": ["Generic Transcription Pathway"], "79759": ["Generic Transcription Pathway"], "7976": ["Class B/2 (Secretin family receptors)", "Ca2+ pathway", "Ca2+ pathway", "PCP/CE pathway", "PCP/CE pathway", "Asymmetric localization of PCP proteins", "Asymmetric localization of PCP proteins"], "79760": ["snRNP Assembly"], "79777": ["Peroxisomal lipid metabolism"], "7978": ["Mitochondrial transcription termination", "Transcriptional activation of mitochondrial biogenesis"], "79784": ["EPHA-mediated growth cone collapse", "Sema4D induced cell migration and growth-cone collapse", "RHO GTPases activate PKNs", "RHO GTPases activate CIT", "RHO GTPases Activate ROCKs", "RHO GTPases activate PAKs", "RHO GTPases activate PAKs"], "79788": ["Generic Transcription Pathway"], "7979": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "79791": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "79792": ["Neutrophil degranulation"], "79796": ["Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "Defective ALG9 causes ALG9-CDG (CDG-1l)"], "79799": ["Glucuronidation"], "79809": ["Hedgehog 'off' state", "Intraflagellar transport"], "79813": ["Senescence-Associated Secretory Phenotype (SASP)", "PKMTs methylate histone lysines", "Regulation of TP53 Activity through Methylation", "Transcriptional Regulation by E2F6"], "79814": ["Agmatine biosynthesis"], "79815": ["Miscellaneous transport and binding events"], "79818": ["Generic Transcription Pathway"], "79820": ["Sperm Motility And Taxes"], "79823": ["Inactivation, recovery and regulation of the phototransduction cascade", "Protein methylation"], "79831": ["HDMs demethylate histones"], "79833": ["snRNP Assembly"], "79837": ["Synthesis of PIPs at the plasma membrane", "PI5P Regulates TP53 Acetylation", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Synthesis of PIPs in the nucleus"], "7984": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "79840": ["Nonhomologous End-Joining (NHEJ)"], "79841": ["Carboxyterminal post-translational modifications of tubulin"], "79849": ["Intestinal infectious diseases"], "79861": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "Gap junction assembly", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Recruitment of NuMA to mitotic centrosomes", "Formation of tubulin folding intermediates by CCT/TriC", "Post-chaperonin tubulin folding pathway", "Recycling pathway of L1", "Recycling pathway of L1", "Cilium Assembly", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "Carboxyterminal post-translational modifications of tubulin", "Carboxyterminal post-translational modifications of tubulin", "Activation of AMPK downstream of NMDARs", "Kinesins"], "79862": ["Generic Transcription Pathway"], "79865": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "79866": ["Regulation of PLK1 Activity at G2/M Transition"], "79867": ["Anchoring of the basal body to the plasma membrane"], "79868": ["Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)"], "79869": ["Cleavage of Growing Transcript in the Termination Region ", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "79871": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes"], "79872": ["InlA-mediated entry of Listeria monocytogenes into host cells"], "79873": ["Phosphate bond hydrolysis by NUDT proteins"], "79875": ["Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "79876": ["Antigen processing: Ubiquitination & Proteasome degradation"], "7988": ["Generic Transcription Pathway"], "79885": ["NOTCH1 Intracellular Domain Regulates Transcription", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants"], "79887": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PE", "Acyl chain remodelling of PI", "Hydrolysis of LPC"], "79888": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PG", "Synthesis of PA", "Synthesis of PC", "Neutrophil degranulation"], "79890": ["RAB GEFs exchange GTP for GDP on RABs"], "79891": ["Generic Transcription Pathway"], "79895": ["Neutrophil degranulation", "Ion transport by P-type ATPases"], "79897": ["tRNA processing in the nucleus", "Major pathway of rRNA processing in the nucleolus and cytosol"], "79898": ["Generic Transcription Pathway"], "799": ["G alpha (s) signalling events", "Calcitonin-like ligand receptors"], "79901": ["Iron uptake and transport"], "79902": ["ISG15 antiviral mechanism", "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "RHO GTPases Activate Formins", "tRNA processing in the nucleus", "Mitotic Prometaphase"], "79908": ["Butyrophilin (BTN) family interactions"], "7991": ["Asparagine N-linked glycosylation", "Miscellaneous transport and binding events"], "79913": ["UCH proteinases", "DNA Damage Recognition in GG-NER"], "79918": ["PKMTs methylate histone lysines"], "79922": ["rRNA modification in the mitochondrion"], "79923": ["POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation", "POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation", "Transcriptional regulation of pluripotent stem cells", "Interleukin-4 and Interleukin-13 signaling"], "79924": ["G alpha (s) signalling events", "Calcitonin-like ligand receptors"], "79930": ["Neutrophil degranulation"], "79931": ["Ovarian tumor domain proteases"], "7994": ["HATs acetylate histones", "Regulation of TP53 Activity through Acetylation"], "79943": ["Generic Transcription Pathway"], "79944": ["Interconversion of 2-oxoglutarate and 2-hydroxyglutarate"], "79947": ["Synthesis of Dolichyl-phosphate", "Defective DHDDS causes retinitis pigmentosa 59"], "79948": ["Lysosphingolipid and LPA receptors"], "79958": ["RAB GEFs exchange GTP for GDP on RABs"], "79959": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "79960": ["HATs acetylate histones"], "79961": ["RAB GEFs exchange GTP for GDP on RABs"], "79966": ["Fatty acyl-CoA biosynthesis"], "79969": ["Cilium Assembly"], "79971": ["WNT ligand biogenesis and trafficking"], "79973": ["Generic Transcription Pathway"], "79980": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Neutrophil degranulation", "Mitotic Prometaphase"], "79989": ["Intraflagellar transport", "Intraflagellar transport"], "79993": ["Synthesis of very long-chain fatty acyl-CoAs"], "800": ["Smooth Muscle Contraction"], "8000": ["Post-translational modification: synthesis of GPI-anchored proteins"], "80004": ["FGFR2 alternative splicing"], "80005": ["Factors involved in megakaryocyte development and platelet production"], "80006": ["RAB GEFs exchange GTP for GDP on RABs"], "8001": ["Neurotransmitter receptors and postsynaptic signal transmission"], "80010": ["HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Regulation of TP53 Activity through Phosphorylation", "G2/M DNA damage checkpoint"], "80012": ["Oxidative Stress Induced Senescence", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of transcription cofactors", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA methylation proteins", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription", "Transcriptional Regulation by E2F6"], "80024": ["Sodium/Calcium exchangers", "Mitochondrial calcium ion transport"], "80025": ["Coenzyme A biosynthesis"], "80031": ["Other semaphorin interactions"], "80032": ["Generic Transcription Pathway"], "80036": ["TRP channels"], "80055": ["Attachment of GPI anchor to uPAR"], "80059": ["Neurexins and neuroligins"], "80067": ["Neddylation"], "80070": ["Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "80095": ["Generic Transcription Pathway"], "80097": ["Recruitment of mitotic centrosome proteins and complexes", "Recruitment of NuMA to mitotic centrosomes"], "801": ["CaMK IV-mediated phosphorylation of CREB", "CaMK IV-mediated phosphorylation of CREB", "Calmodulin induced events", "Cam-PDE 1 activation", "CaM pathway", "Platelet degranulation ", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "PKA activation", "DARPP-32 events", "Synthesis of IP3 and IP4 in the cytosol", "Calcineurin activates NFAT", "Calcineurin activates NFAT", "eNOS activation", "Transcriptional activation of mitochondrial biogenesis", "Inactivation, recovery and regulation of the phototransduction cascade", "Inactivation, recovery and regulation of the phototransduction cascade", "Stimuli-sensing channels", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "Ca2+ pathway", "Reduction of cytosolic Ca++ levels", "Sodium/Calcium exchangers", "Unblocking of NMDA receptors, glutamate binding and activation", "CREB1 phosphorylation through the activation of Adenylate Cyclase", "CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "Ras activation upon Ca2+ influx through NMDA receptor", "Smooth Muscle Contraction", "Smooth Muscle Contraction", "Activation of Ca-permeable Kainate Receptor", "Uptake and function of anthrax toxins", "VEGFR2 mediated vascular permeability", "VEGFR2 mediated cell proliferation", "Phase 0 - rapid depolarisation", "Ion homeostasis", "CLEC7A (Dectin-1) induces NFAT activation", "CLEC7A (Dectin-1) induces NFAT activation", "RHO GTPases activate IQGAPs", "RHO GTPases activate PAKs", "RHO GTPases activate PAKs", "RAF activation", "RAF/MAP kinase cascade", "Signaling by moderate kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF", "Glycogen breakdown (glycogenolysis)", "Glycogen breakdown (glycogenolysis)", "Protein methylation", "Loss of phosphorylation of MECP2 at T308", "Regulation of MECP2 expression and activity", "Ion transport by P-type ATPases", "Negative regulation of NMDA receptor-mediated neuronal transmission", "Activation of RAC1 downstream of NMDARs", "Activation of RAC1 downstream of NMDARs", "Activation of AMPK downstream of NMDARs", "Long-term potentiation", "Long-term potentiation", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "80108": ["Generic Transcription Pathway"], "80110": ["Generic Transcription Pathway"], "80124": ["Ovarian tumor domain proteases"], "80128": ["Interferon gamma signaling"], "8013": ["Nuclear Receptor transcription pathway", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"], "80131": ["Miscellaneous transport and binding events"], "80139": ["Generic Transcription Pathway"], "80142": ["Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "Neutrophil degranulation"], "80143": ["TRAF3-dependent IRF activation pathway", "TRAF6 mediated IRF7 activation"], "80145": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA 3'-end processing"], "80150": ["Phenylalanine and tyrosine catabolism"], "80152": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Deposition of new CENPA-containing nucleosomes at the centromere", "Mitotic Prometaphase"], "80153": ["mRNA decay by 5' to 3' exoribonuclease"], "80168": ["Triglyceride biosynthesis"], "80173": ["Intraflagellar transport", "Intraflagellar transport"], "80176": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "80184": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "Neutrophil degranulation", "AURKA Activation by TPX2"], "80196": ["Regulation of TP53 Degradation", "Antigen processing: Ubiquitination & Proteasome degradation"], "80198": ["Resolution of D-loop Structures through Holliday Junction Intermediates", "Fanconi Anemia Pathway"], "80199": ["Hedgehog 'off' state"], "80204": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "80205": ["RORA activates gene expression", "BMAL1:CLOCK,NPAS2 activates circadian gene expression", "PPARA activates gene expression", "PPARA activates gene expression", "Transcriptional activation of mitochondrial biogenesis", "Activation of gene expression by SREBF (SREBP)", "Transcriptional regulation of white adipocyte differentiation", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)", "Circadian Clock"], "8021": ["ISG15 antiviral mechanism", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "HuR (ELAVL1) binds and stabilizes mRNA", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "tRNA processing in the nucleus"], "80219": ["Respiratory electron transport"], "8022": ["Regulation of expression of SLITs and ROBOs"], "80221": ["Mitochondrial Fatty Acid Beta-Oxidation"], "80222": ["Mitochondrial tRNA aminoacylation"], "80224": ["Complex I biogenesis"], "80228": ["Elevation of cytosolic Ca2+ levels", "Ion homeostasis", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "80230": ["Synthesis of PIPs at the plasma membrane"], "80233": ["Fanconi Anemia Pathway"], "80235": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "80237": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes"], "80243": ["Regulation of PTEN stability and activity"], "80254": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "80263": ["Interferon gamma signaling"], "80264": ["Generic Transcription Pathway"], "80267": ["ER Quality Control Compartment (ERQC)"], "8027": ["EGFR downregulation", "Metalloprotease DUBs", "Negative regulation of MET activity", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "InlB-mediated entry of Listeria monocytogenes into host cell", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "80270": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of bile acids and bile salts via 24-hydroxycholesterol", "Synthesis of bile acids and bile salts via 27-hydroxycholesterol"], "80271": ["Synthesis of IP3 and IP4 in the cytosol"], "80273": ["Mitochondrial protein import"], "80274": ["Degradation of the extracellular matrix"], "8029": ["Cobalamin (Cbl, vitamin B12) transport and metabolism", "Vitamin D (calciferol) metabolism", "Defective AMN causes hereditary megaloblastic anemia 1", "Defective CUBN causes hereditary megaloblastic anemia 1", "HDL clearance"], "80301": ["Neutrophil degranulation"], "80306": ["PPARA activates gene expression", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "80308": ["Vitamin B2 (riboflavin) metabolism"], "80310": ["Signaling by PDGF"], "80312": ["TET1,2,3 and TDG demethylate DNA"], "80314": ["HATs acetylate histones", "Transcriptional Regulation by E2F6"], "80317": ["Generic Transcription Pathway"], "80321": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "80324": ["tRNA modification in the nucleus and cytosol", "tRNA modification in the mitochondrion"], "80326": ["WNT ligand biogenesis and trafficking", "WNT ligand biogenesis and trafficking", "Class B/2 (Secretin family receptors)"], "80328": ["Post-translational modification: synthesis of GPI-anchored proteins"], "80329": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "80331": ["Neutrophil degranulation", "GABA synthesis, release, reuptake and degradation"], "80333": ["Phase 1 - inactivation of fast Na+ channels"], "80339": ["Acyl chain remodeling of DAG and TAG"], "8034": ["Coenzyme A biosynthesis"], "80341": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Antimicrobial peptides", "Post-translational protein phosphorylation"], "80344": ["Neddylation"], "80346": ["Olfactory Signaling Pathway"], "80347": ["Coenzyme A biosynthesis"], "80349": ["Formation of RNA Pol II elongation complex ", "mRNA decay by 3' to 5' exoribonuclease", "RNA Polymerase II Pre-transcription Events", "RNA Polymerase II Transcription Elongation", "E3 ubiquitin ligases ubiquitinate target proteins"], "80351": ["TCF dependent signaling in response to WNT", "Degradation of AXIN", "XAV939 inhibits tankyrase, stabilizing AXIN", "Ub-specific processing proteases", "Regulation of PTEN stability and activity"], "8038": ["Signaling by EGFR", "Invadopodia formation"], "80380": ["PD-1 signaling"], "805": ["CaMK IV-mediated phosphorylation of CREB", "CaMK IV-mediated phosphorylation of CREB", "Calmodulin induced events", "Cam-PDE 1 activation", "CaM pathway", "Platelet degranulation ", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "PKA activation", "DARPP-32 events", "Synthesis of IP3 and IP4 in the cytosol", "Calcineurin activates NFAT", "Calcineurin activates NFAT", "eNOS activation", "Transcriptional activation of mitochondrial biogenesis", "Inactivation, recovery and regulation of the phototransduction cascade", "Inactivation, recovery and regulation of the phototransduction cascade", "Stimuli-sensing channels", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "Ca2+ pathway", "Reduction of cytosolic Ca++ levels", "Sodium/Calcium exchangers", "Unblocking of NMDA receptors, glutamate binding and activation", "CREB1 phosphorylation through the activation of Adenylate Cyclase", "CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "Ras activation upon Ca2+ influx through NMDA receptor", "Smooth Muscle Contraction", "Smooth Muscle Contraction", "Activation of Ca-permeable Kainate Receptor", "Uptake and function of anthrax toxins", "VEGFR2 mediated vascular permeability", "VEGFR2 mediated cell proliferation", "Phase 0 - rapid depolarisation", "Ion homeostasis", "CLEC7A (Dectin-1) induces NFAT activation", "CLEC7A (Dectin-1) induces NFAT activation", "RHO GTPases activate IQGAPs", "RHO GTPases activate PAKs", "RHO GTPases activate PAKs", "RAF activation", "RAF/MAP kinase cascade", "Signaling by moderate kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF", "Glycogen breakdown (glycogenolysis)", "Glycogen breakdown (glycogenolysis)", "Protein methylation", "Loss of phosphorylation of MECP2 at T308", "Regulation of MECP2 expression and activity", "Ion transport by P-type ATPases", "Negative regulation of NMDA receptor-mediated neuronal transmission", "Activation of RAC1 downstream of NMDARs", "Activation of RAC1 downstream of NMDARs", "Activation of AMPK downstream of NMDARs", "Long-term potentiation", "Long-term potentiation", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "8050": ["Regulation of pyruvate dehydrogenase (PDH) complex", "Glyoxylate metabolism and glycine degradation", "Signaling by Retinoic Acid", "Pyruvate metabolism"], "8065": ["Vif-mediated degradation of APOBEC3G", "Downregulation of ERBB2 signaling", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "80704": ["Vitamin B1 (thiamin) metabolism"], "80724": ["Mitochondrial Fatty Acid Beta-Oxidation"], "80727": ["Stimuli-sensing channels"], "80728": ["Rho GTPase cycle", "Inactivation of CDC42 and RAC1"], "8073": ["RAB geranylgeranylation"], "80736": ["Synthesis of PC", "Transport of bile salts and organic acids, metal ions and amine compounds"], "80739": ["GPVI-mediated activation cascade"], "8074": ["PI3K Cascade", "PIP3 activates AKT signaling", "Signaling by activated point mutants of FGFR1", "Signaling by activated point mutants of FGFR3", "FGFR4 ligand binding and activation", "FGFR3c ligand binding and activation", "FGFR1c ligand binding and activation", "FGFR1c and Klotho ligand binding and activation", "FGFR2c ligand binding and activation", "FGFR3 mutant receptor activation", "Activated point mutants of FGFR2", "Constitutive Signaling by Aberrant PI3K in Cancer", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Phospholipase C-mediated cascade: FGFR1", "Phospholipase C-mediated cascade; FGFR2", "Phospholipase C-mediated cascade; FGFR3", "Phospholipase C-mediated cascade; FGFR4", "Downstream signaling of activated FGFR1", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "PI-3K cascade:FGFR3", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "PI-3K cascade:FGFR4", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "Signaling by FGFR2 in disease", "Signaling by FGFR1 in disease", "FGFRL1 modulation of FGFR1 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Signaling by FGFR3 point mutants in cancer", "Post-translational protein phosphorylation"], "80740": ["Post-translational modification: synthesis of GPI-anchored proteins"], "80746": ["tRNA processing in the nucleus"], "8076": ["Elastic fibre formation", "Molecules associated with elastic fibres", "Molecules associated with elastic fibres"], "80765": ["Recycling of bile acids and salts"], "80772": ["Glycosphingolipid metabolism"], "80776": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Anchoring of the basal body to the plasma membrane", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "80777": ["Phase I - Functionalization of compounds"], "80778": ["Generic Transcription Pathway"], "8078": ["Ub-specific processing proteases", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes"], "80781": ["Collagen degradation", "Activation of Matrix Metalloproteinases", "Collagen biosynthesis and modifying enzymes", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "Laminin interactions", "Collagen chain trimerization"], "80789": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes"], "808": ["CaMK IV-mediated phosphorylation of CREB", "CaMK IV-mediated phosphorylation of CREB", "Calmodulin induced events", "Cam-PDE 1 activation", "CaM pathway", "Platelet degranulation ", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "PKA activation", "DARPP-32 events", "Synthesis of IP3 and IP4 in the cytosol", "Calcineurin activates NFAT", "Calcineurin activates NFAT", "eNOS activation", "Transcriptional activation of mitochondrial biogenesis", "Inactivation, recovery and regulation of the phototransduction cascade", "Inactivation, recovery and regulation of the phototransduction cascade", "Stimuli-sensing channels", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "Ca2+ pathway", "Reduction of cytosolic Ca++ levels", "Sodium/Calcium exchangers", "Unblocking of NMDA receptors, glutamate binding and activation", "CREB1 phosphorylation through the activation of Adenylate Cyclase", "CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "Ras activation upon Ca2+ influx through NMDA receptor", "Smooth Muscle Contraction", "Smooth Muscle Contraction", "Activation of Ca-permeable Kainate Receptor", "Uptake and function of anthrax toxins", "VEGFR2 mediated vascular permeability", "VEGFR2 mediated cell proliferation", "Phase 0 - rapid depolarisation", "Ion homeostasis", "CLEC7A (Dectin-1) induces NFAT activation", "CLEC7A (Dectin-1) induces NFAT activation", "RHO GTPases activate IQGAPs", "RHO GTPases activate PAKs", "RHO GTPases activate PAKs", "RAF activation", "RAF/MAP kinase cascade", "Signaling by moderate kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF", "Glycogen breakdown (glycogenolysis)", "Glycogen breakdown (glycogenolysis)", "Protein methylation", "Loss of phosphorylation of MECP2 at T308", "Regulation of MECP2 expression and activity", "Ion transport by P-type ATPases", "Negative regulation of NMDA receptor-mediated neuronal transmission", "Activation of RAC1 downstream of NMDARs", "Activation of RAC1 downstream of NMDARs", "Activation of AMPK downstream of NMDARs", "Long-term potentiation", "Long-term potentiation", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "80818": ["Generic Transcription Pathway"], "80821": ["Synthesis of PA"], "80824": ["RAF-independent MAPK1/3 activation", "Negative regulation of MAPK pathway"], "80834": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "80835": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "8085": ["Formation of the beta-catenin:TCF transactivating complex", "PKMTs methylate histone lysines", "Deactivation of the beta-catenin transactivating complex", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"], "80852": ["Trafficking of GluR2-containing AMPA receptors"], "80853": ["HDMs demethylate histones", "Signaling by BRAF and RAF fusions"], "80854": ["PKMTs methylate histone lysines"], "8086": ["ISG15 antiviral mechanism", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "tRNA processing in the nucleus"], "8087": ["Signaling by BRAF and RAF fusions"], "8089": ["HATs acetylate histones", "Activation of the TFAP2 (AP-2) family of transcription factors"], "80896": ["Sialic acid metabolism"], "8091": ["Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "81": ["Platelet degranulation ", "Nephrin family interactions"], "8100": ["Hedgehog 'off' state", "Intraflagellar transport", "Intraflagellar transport"], "81025": ["Gap junction assembly"], "81027": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "Gap junction assembly", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Recruitment of NuMA to mitotic centrosomes", "Prefoldin mediated transfer of substrate to CCT/TriC", "Formation of tubulin folding intermediates by CCT/TriC", "Post-chaperonin tubulin folding pathway", "Recycling pathway of L1", "Recycling pathway of L1", "Hedgehog 'off' state", "Cilium Assembly", "Intraflagellar transport", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "Carboxyterminal post-translational modifications of tubulin", "Carboxyterminal post-translational modifications of tubulin", "Activation of AMPK downstream of NMDARs", "Kinesins"], "81029": ["WNT ligand biogenesis and trafficking", "WNT ligand biogenesis and trafficking", "PCP/CE pathway", "PCP/CE pathway"], "81030": ["ZBP1(DAI) mediated induction of type I IFNs", "IRF3 mediated activation of type 1 IFN", "IRF3 mediated activation of type 1 IFN", "RIP-mediated NFkB activation via ZBP1", "Regulation of innate immune responses to cytosolic DNA"], "81031": ["Cellular hexose transport", "Defective SLC2A10 causes arterial tortuosity syndrome (ATS)"], "81033": ["Voltage gated Potassium channels"], "81034": ["Metabolism of folate and pterines"], "81035": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Scavenging by Class A Receptors"], "81050": ["Olfactory Signaling Pathway"], "8106": ["Cleavage of Growing Transcript in the Termination Region ", "Inhibition of Host mRNA Processing and RNA Silencing", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "81061": ["Olfactory Signaling Pathway"], "81099": ["Olfactory Signaling Pathway"], "811": ["ER-Phagosome pathway", "Assembly of Viral Components at the Budding Site", "Scavenging by Class A Receptors", "Scavenging by Class A Receptors", "Scavenging by Class F Receptors", "Scavenging by Class F Receptors", "ATF6 (ATF6-alpha) activates chaperone genes", "Calnexin/calreticulin cycle", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "8111": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (q) signalling events"], "81127": ["Olfactory Signaling Pathway"], "81168": ["Olfactory Signaling Pathway"], "8125": ["HuR (ELAVL1) binds and stabilizes mRNA"], "8128": ["Sialic acid metabolism", "NCAM1 interactions", "N-Glycan antennae elongation"], "81282": ["Olfactory Signaling Pathway"], "81285": ["Olfactory Signaling Pathway"], "813": ["Platelet degranulation ", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "81300": ["Olfactory Signaling Pathway"], "81309": ["Olfactory Signaling Pathway"], "81318": ["Olfactory Signaling Pathway"], "81327": ["Olfactory Signaling Pathway"], "81328": ["Olfactory Signaling Pathway"], "81341": ["Olfactory Signaling Pathway"], "8139": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "81392": ["Olfactory Signaling Pathway"], "813949": ["Cell surface interactions at the vascular wall"], "81399": ["Olfactory Signaling Pathway"], "814": ["CaMK IV-mediated phosphorylation of CREB", "CaMK IV-mediated phosphorylation of CREB", "Transcriptional activation of mitochondrial biogenesis", "CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "Loss of phosphorylation of MECP2 at T308", "Regulation of MECP2 expression and activity", "Negative regulation of NMDA receptor-mediated neuronal transmission"], "8140": ["Basigin interactions", "Amino acid transport across the plasma membrane", "Tryptophan catabolism"], "81442": ["Olfactory Signaling Pathway"], "81448": ["Olfactory Signaling Pathway"], "81466": ["Olfactory Signaling Pathway"], "81469": ["Olfactory Signaling Pathway"], "81470": ["Olfactory Signaling Pathway"], "81472": ["Olfactory Signaling Pathway"], "8148": ["HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "81490": ["Synthesis of PS"], "81494": ["Regulation of Complement cascade"], "815": ["CaMK IV-mediated phosphorylation of CREB", "HSF1-dependent transactivation", "Trafficking of AMPA receptors", "Ca2+ pathway", "Unblocking of NMDA receptors, glutamate binding and activation", "Phase 0 - rapid depolarisation", "Ion homeostasis", "RAF activation", "Signaling by moderate kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF", "Interferon gamma signaling", "Regulation of MECP2 expression and activity", "Ion transport by P-type ATPases", "Negative regulation of NMDA receptor-mediated neuronal transmission", "Long-term potentiation"], "81501": ["CREB3 factors activate genes"], "81537": ["Sphingolipid de novo biosynthesis"], "81539": ["Astrocytic Glutamate-Glutamine Uptake And Metabolism", "Amino acid transport across the plasma membrane"], "81544": ["Glycerophospholipid catabolism"], "81556": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes"], "81559": ["Antigen processing: Ubiquitination & Proteasome degradation"], "81562": ["COPII-mediated vesicle transport", "Cargo concentration in the ER"], "81565": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "81567": ["Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis", "Neutrophil degranulation"], "81578": ["Collagen biosynthesis and modifying enzymes", "Collagen chain trimerization"], "81579": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PS", "Acyl chain remodelling of PE", "Acyl chain remodelling of PI", "Acyl chain remodelling of PG", "Synthesis of PA"], "816": ["CaMK IV-mediated phosphorylation of CREB", "HSF1-dependent transactivation", "Trafficking of AMPA receptors", "Unblocking of NMDA receptors, glutamate binding and activation", "CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "Phase 0 - rapid depolarisation", "Ion homeostasis", "RAF activation", "Signaling by moderate kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF", "Interferon gamma signaling", "Regulation of MECP2 expression and activity", "Ion transport by P-type ATPases", "Negative regulation of NMDA receptor-mediated neuronal transmission", "Long-term potentiation"], "81603": ["Interferon gamma signaling"], "81605": ["tRNA modification in the nucleus and cytosol"], "81607": ["Adherens junctions interactions", "Nectin/Necl trans heterodimerization"], "81608": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA Derived from an Intronless Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "81614": ["Miscellaneous transport and binding events"], "81616": ["Synthesis of very long-chain fatty acyl-CoAs"], "81617": ["Energy dependent regulation of mTOR by LKB1-AMPK"], "81619": ["Neutrophil degranulation", "Amyloid fiber formation"], "81620": ["Activation of E2F1 target genes at G1/S", "CDT1 association with the CDC6:ORC:origin complex", "Assembly of the pre-replicative complex", "Orc1 removal from chromatin", "Activation of the pre-replicative complex"], "81622": ["Trafficking and processing of endosomal TLR", "UNC93B1 deficiency - HSE"], "81623": ["Beta defensins", "Defensins"], "81624": ["RHO GTPases Activate Formins"], "81631": ["Macroautophagy", "Pink/Parkin Mediated Mitophagy", "TBC/RABGAPs", "Receptor Mediated Mitophagy"], "8165": ["Mitochondrial calcium ion transport", "Factors involved in megakaryocyte development and platelet production"], "81689": ["Mitochondrial iron-sulfur cluster biogenesis"], "81693": ["Cobalamin (Cbl, vitamin B12) transport and metabolism", "Defective AMN causes hereditary megaloblastic anemia 1", "Defective CUBN causes hereditary megaloblastic anemia 1", "HDL clearance"], "81696": ["Olfactory Signaling Pathway"], "81697": ["Olfactory Signaling Pathway"], "817": ["CaMK IV-mediated phosphorylation of CREB", "HSF1-dependent transactivation", "Trafficking of AMPA receptors", "Unblocking of NMDA receptors, glutamate binding and activation", "Phase 0 - rapid depolarisation", "Ion homeostasis", "RAF activation", "Signaling by moderate kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF", "Interferon gamma signaling", "Regulation of MECP2 expression and activity", "Ion transport by P-type ATPases", "Negative regulation of NMDA receptor-mediated neuronal transmission", "Long-term potentiation"], "8170": ["Transport of bile salts and organic acids, metal ions and amine compounds"], "81704": ["Factors involved in megakaryocyte development and platelet production"], "8174": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Integrin cell surface interactions"], "8175": ["mRNA Splicing - Major Pathway"], "8178": ["Formation of RNA Pol II elongation complex ", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "RNA Polymerase II Pre-transcription Events", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "TP53 Regulates Transcription of DNA Repair Genes", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Transcription Elongation"], "81792": ["Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "81793": ["Toll Like Receptor 10 (TLR10) Cascade", "IRAK4 deficiency (TLR5)", "MyD88 cascade initiated on plasma membrane"], "81794": ["Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "81797": ["Olfactory Signaling Pathway"], "818": ["CaMK IV-mediated phosphorylation of CREB", "HSF1-dependent transactivation", "Trafficking of AMPA receptors", "Unblocking of NMDA receptors, glutamate binding and activation", "CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "Phase 0 - rapid depolarisation", "Ion homeostasis", "RAF activation", "Signaling by moderate kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF", "Interferon gamma signaling", "Regulation of MECP2 expression and activity", "Ion transport by P-type ATPases", "Negative regulation of NMDA receptor-mediated neuronal transmission", "Long-term potentiation"], "81844": ["Regulation of innate immune responses to cytosolic DNA"], "81846": ["Synthesis of PIPs at the plasma membrane", "RAB GEFs exchange GTP for GDP on RABs"], "81847": ["TCF dependent signaling in response to WNT", "Degradation of AXIN", "Ub-specific processing proteases", "Regulation of PTEN stability and activity"], "81849": ["Sialic acid metabolism"], "81850": ["Keratinization"], "81851": ["Keratinization"], "81856": ["Generic Transcription Pathway"], "81857": ["PPARA activates gene expression", "Generic Transcription Pathway", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "81858": ["Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "Neurexins and neuroligins"], "81870": ["Keratinization"], "81871": ["Keratinization"], "81872": ["Keratinization"], "81875": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "81876": ["Golgi Cisternae Pericentriolar Stack Reorganization", "Golgi Cisternae Pericentriolar Stack Reorganization", "COPII-mediated vesicle transport", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "81887": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "81889": ["Citric acid cycle (TCA cycle)"], "8189": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA Derived from an Intronless Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "81890": ["tRNA modification in the nucleus and cytosol"], "81894": ["Mitochondrial iron-sulfur cluster biogenesis"], "81928": ["Factors involved in megakaryocyte development and platelet production"], "81929": ["ISG15 antiviral mechanism", "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "RHO GTPases Activate Formins", "tRNA processing in the nucleus", "Mitotic Prometaphase"], "81930": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "COPI-dependent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "Kinesins", "Kinesins"], "8195": ["BBSome-mediated cargo-targeting to cilium"], "820": ["Neutrophil degranulation", "Antimicrobial peptides"], "8200": ["Molecules associated with elastic fibres"], "8202": ["PPARA activates gene expression", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "MAPK6/MAPK4 signaling", "Estrogen-dependent gene expression"], "8204": ["SUMOylation of transcription cofactors", "Circadian Clock", "Estrogen-dependent gene expression"], "821": ["Assembly of Viral Components at the Budding Site", "MHC class II antigen presentation", "Interleukin-35 Signalling", "Calnexin/calreticulin cycle", "Interleukin-27 signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "8218": ["Gap junction degradation", "Formation of annular gap junctions", "EPH-ephrin mediated repulsion of cells", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "8224": ["Serotonin Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle"], "8226": ["Pyrimidine salvage"], "8228": ["Triglyceride catabolism"], "823": ["Degradation of the extracellular matrix", "Degradation of the extracellular matrix", "Neutrophil degranulation", "Formation of the cornified envelope", "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models"], "8233": ["mRNA Splicing - Minor Pathway"], "8237": ["Association of TriC/CCT with target proteins during biosynthesis", "Ub-specific processing proteases"], "8239": ["Downregulation of SMAD2/3:SMAD4 transcriptional activity", "Ub-specific processing proteases", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Peroxisomal protein import", "Peroxisomal protein import", "Amyloid fiber formation"], "824": ["Degradation of the extracellular matrix", "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models"], "8242": ["HDMs demethylate histones"], "8243": ["Meiotic synapsis", "Separation of Sister Chromatids", "Establishment of Sister Chromatid Cohesion", "Cohesin Loading onto Chromatin", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA damage response and repair proteins", "Estrogen-dependent gene expression"], "825": ["Degradation of the extracellular matrix"], "826": ["Degradation of the extracellular matrix", "Degradation of the extracellular matrix", "Formation of the cornified envelope", "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models"], "827": ["Degradation of the extracellular matrix"], "8270": ["tRNA modification in the nucleus and cytosol"], "8284": ["HDMs demethylate histones"], "8288": ["Neutrophil degranulation"], "8289": ["RMTs methylate histone arginines", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "829": ["MHC class II antigen presentation", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic", "Advanced glycosylation endproduct receptor signaling", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "Factors involved in megakaryocyte development and platelet production", "Factors involved in megakaryocyte development and platelet production"], "8290": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "Condensation of Prophase Chromosomes", "DNA Damage/Telomere Stress Induced Senescence", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "G2/M DNA damage checkpoint", "Meiotic recombination"], "8291": ["Smooth Muscle Contraction", "Smooth Muscle Contraction"], "8294": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "SUMOylation of chromatin organization proteins", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "8295": ["Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "HATs acetylate histones", "Ub-specific processing proteases"], "830": ["MHC class II antigen presentation", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic", "Advanced glycosylation endproduct receptor signaling", "Factors involved in megakaryocyte development and platelet production", "Factors involved in megakaryocyte development and platelet production"], "8301": ["Golgi Associated Vesicle Biogenesis", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "8309": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Beta-oxidation of pristanoyl-CoA", "Peroxisomal protein import", "Peroxisomal protein import"], "831": ["Degradation of the extracellular matrix", "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models"], "8310": ["Beta-oxidation of pristanoyl-CoA", "Peroxisomal protein import", "Peroxisomal protein import"], "8312": ["Degradation of beta-catenin by the destruction complex", "Beta-catenin phosphorylation cascade", "TCF dependent signaling in response to WNT", "Degradation of AXIN", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Misspliced GSK3beta mutants stabilize beta-catenin", "S33 mutants of beta-catenin aren't phosphorylated", "S37 mutants of beta-catenin aren't phosphorylated", "S45 mutants of beta-catenin aren't phosphorylated", "T41 mutants of beta-catenin aren't phosphorylated", "APC truncation mutants have impaired AXIN binding", "AXIN missense mutants destabilize the destruction complex", "Truncations of AMER1 destabilize the destruction complex", "Ub-specific processing proteases", "RUNX1 regulates estrogen receptor mediated transcription", "RUNX1 regulates transcription of genes involved in WNT signaling", "Estrogen-dependent gene expression"], "8313": ["TCF dependent signaling in response to WNT", "Binding of TCF/LEF:CTNNB1 to target gene promoters", "Degradation of AXIN", "Ub-specific processing proteases"], "8314": ["UCH proteinases", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"], "8315": ["RAF activation", "Negative regulation of MAPK pathway", "Signaling by moderate kinase activity BRAF mutants", "Signaling by RAS mutants", "Paradoxical activation of RAF signaling by kinase inactive BRAF"], "8317": ["Activation of ATR in response to replication stress", "Activation of the pre-replicative complex", "Transcriptional Regulation by E2F6"], "8318": ["Activation of ATR in response to replication stress", "Unwinding of DNA", "Activation of E2F1 target genes at G1/S", "Activation of the pre-replicative complex"], "832": ["MHC class II antigen presentation", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic", "Factors involved in megakaryocyte development and platelet production", "Factors involved in megakaryocyte development and platelet production"], "8321": ["TCF dependent signaling in response to WNT", "Class B/2 (Secretin family receptors)", "PCP/CE pathway", "PCP/CE pathway", "Asymmetric localization of PCP proteins", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Disassembly of the destruction complex and recruitment of AXIN to the membrane"], "8322": ["Class B/2 (Secretin family receptors)", "Ca2+ pathway", "Ca2+ pathway", "Asymmetric localization of PCP proteins", "Regulation of FZD by ubiquitination", "WNT5A-dependent internalization of FZD4", "RNF mutants show enhanced WNT signaling and proliferation", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "8323": ["Class B/2 (Secretin family receptors)", "Ca2+ pathway", "Ca2+ pathway", "PCP/CE pathway", "PCP/CE pathway", "Regulation of FZD by ubiquitination", "RNF mutants show enhanced WNT signaling and proliferation"], "8324": ["Class B/2 (Secretin family receptors)", "PCP/CE pathway", "PCP/CE pathway", "Asymmetric localization of PCP proteins"], "8325": ["Class B/2 (Secretin family receptors)", "Asymmetric localization of PCP proteins", "Regulation of FZD by ubiquitination", "RNF mutants show enhanced WNT signaling and proliferation"], "8326": ["Class B/2 (Secretin family receptors)"], "8329": ["HDACs deacetylate histones", "HATs acetylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "UCH proteinases", "Ub-specific processing proteases", "Metalloprotease DUBs"], "833": ["Cytosolic tRNA aminoacylation"], "8330": ["HDACs deacetylate histones", "HATs acetylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "UCH proteinases", "Ub-specific processing proteases", "Metalloprotease DUBs"], "8331": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "HATs acetylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "UCH proteinases", "Ub-specific processing proteases", "Metalloprotease DUBs", "Deposition of new CENPA-containing nucleosomes at the centromere", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "8332": ["HDACs deacetylate histones", "HATs acetylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "UCH proteinases", "Ub-specific processing proteases", "Metalloprotease DUBs"], "8334": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "HATs acetylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "UCH proteinases", "Ub-specific processing proteases", "Metalloprotease DUBs", "Deposition of new CENPA-containing nucleosomes at the centromere", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "8335": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "HATs acetylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "UCH proteinases", "Ub-specific processing proteases", "Metalloprotease DUBs", "Deposition of new CENPA-containing nucleosomes at the centromere", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "8336": ["HDACs deacetylate histones", "HATs acetylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "UCH proteinases", "Ub-specific processing proteases", "Metalloprotease DUBs"], "8337": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "HATs acetylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "UCH proteinases", "Ub-specific processing proteases", "Metalloprotease DUBs", "Deposition of new CENPA-containing nucleosomes at the centromere", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "8338": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "HATs acetylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "UCH proteinases", "Ub-specific processing proteases", "Metalloprotease DUBs", "Deposition of new CENPA-containing nucleosomes at the centromere", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "8339": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "HATs acetylate histones", "HATs acetylate histones", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Ub-specific processing proteases", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "E3 ubiquitin ligases ubiquitinate target proteins", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "83394": ["Synthesis of PI"], "834": ["NOD1/2 Signaling Pathway", "Interleukin-1 processing", "TP53 Regulates Transcription of Caspase Activators and Caspases", "The NLRP3 inflammasome", "The AIM2 inflammasome", "The IPAF inflammasome", "Interleukin-37 signaling"], "8340": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "HATs acetylate histones", "HATs acetylate histones", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Ub-specific processing proteases", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "E3 ubiquitin ligases ubiquitinate target proteins", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "83401": ["Linoleic acid (LA) metabolism", "alpha-linolenic acid (ALA) metabolism", "Synthesis of very long-chain fatty acyl-CoAs"], "8341": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "HATs acetylate histones", "HATs acetylate histones", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Ub-specific processing proteases", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "E3 ubiquitin ligases ubiquitinate target proteins", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "8342": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "HATs acetylate histones", "HATs acetylate histones", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Ub-specific processing proteases", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "E3 ubiquitin ligases ubiquitinate target proteins", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "8343": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "HATs acetylate histones", "HATs acetylate histones", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Ub-specific processing proteases", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "E3 ubiquitin ligases ubiquitinate target proteins", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "83439": ["Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "Deactivation of the beta-catenin transactivating complex", "Ca2+ pathway", "Binding of TCF/LEF:CTNNB1 to target gene promoters", "Repression of WNT target genes", "Repression of WNT target genes", "RUNX3 regulates WNT signaling"], "8344": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "HATs acetylate histones", "HATs acetylate histones", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Ub-specific processing proteases", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "E3 ubiquitin ligases ubiquitinate target proteins", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "83440": ["Glycolysis"], "83443": ["mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "83444": ["UCH proteinases", "DNA Damage Recognition in GG-NER"], "8345": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "HATs acetylate histones", "HATs acetylate histones", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Ub-specific processing proteases", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "E3 ubiquitin ligases ubiquitinate target proteins", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "83452": ["Intra-Golgi traffic", "TBC/RABGAPs", "RAB geranylgeranylation"], "8346": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "HATs acetylate histones", "HATs acetylate histones", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Ub-specific processing proteases", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "E3 ubiquitin ligases ubiquitinate target proteins", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "83464": ["Nuclear signaling by ERBB4", "Regulated proteolysis of p75NTR", "NRIF signals cell death from the nucleus", "Activated NOTCH1 Transmits Signal to the Nucleus", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "NOTCH2 Activation and Transmission of Signal to the Nucleus", "EPH-ephrin mediated repulsion of cells", "NOTCH3 Activation and Transmission of Signal to the Nucleus", "NOTCH4 Activation and Transmission of Signal to the Nucleus", "Noncanonical activation of NOTCH3", "Amyloid fiber formation"], "8347": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "HATs acetylate histones", "HATs acetylate histones", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Ub-specific processing proteases", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "E3 ubiquitin ligases ubiquitinate target proteins", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "83475": ["Hypusine synthesis from eIF5A-lysine"], "83478": ["Rho GTPase cycle"], "8348": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "HATs acetylate histones", "HATs acetylate histones", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Ub-specific processing proteases", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "E3 ubiquitin ligases ubiquitinate target proteins", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "83480": ["tRNA modification in the nucleus and cytosol"], "8349": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "HATs acetylate histones", "HATs acetylate histones", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Ub-specific processing proteases", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "835": ["NOD1/2 Signaling Pathway", "NADE modulates death signalling", "TP53 Regulates Transcription of Caspase Activators and Caspases"], "8350": ["Interleukin-7 signaling", "Interleukin-7 signaling", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "HDACs deacetylate histones", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "Chromatin modifying enzymes", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation", "Factors involved in megakaryocyte development and platelet production"], "8351": ["Interleukin-7 signaling", "Interleukin-7 signaling", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "HDACs deacetylate histones", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "Chromatin modifying enzymes", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation", "Factors involved in megakaryocyte development and platelet production"], "8352": ["Interleukin-7 signaling", "Interleukin-7 signaling", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "HDACs deacetylate histones", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "Chromatin modifying enzymes", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation", "Factors involved in megakaryocyte development and platelet production"], "8353": ["Interleukin-7 signaling", "Interleukin-7 signaling", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "HDACs deacetylate histones", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "Chromatin modifying enzymes", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation", "Factors involved in megakaryocyte development and platelet production"], "83539": ["Chondroitin sulfate biosynthesis"], "8354": ["Interleukin-7 signaling", "Interleukin-7 signaling", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "HDACs deacetylate histones", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "Chromatin modifying enzymes", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation", "Factors involved in megakaryocyte development and platelet production"], "83540": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "83547": ["MHC class II antigen presentation"], "83548": ["COPI-mediated anterograde transport", "Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network"], "83549": ["Pyrimidine salvage"], "8355": ["Interleukin-7 signaling", "Interleukin-7 signaling", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "HDACs deacetylate histones", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "Chromatin modifying enzymes", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation", "Factors involved in megakaryocyte development and platelet production"], "83551": ["Amine ligand-binding receptors", "G alpha (s) signalling events"], "8356": ["Interleukin-7 signaling", "Interleukin-7 signaling", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "HDACs deacetylate histones", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "Chromatin modifying enzymes", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation", "Factors involved in megakaryocyte development and platelet production"], "8357": ["Interleukin-7 signaling", "Interleukin-7 signaling", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "HDACs deacetylate histones", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "Chromatin modifying enzymes", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation", "Factors involved in megakaryocyte development and platelet production"], "8358": ["Interleukin-7 signaling", "Interleukin-7 signaling", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "HDACs deacetylate histones", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "Chromatin modifying enzymes", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation", "Factors involved in megakaryocyte development and platelet production"], "8359": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "SUMOylation of chromatin organization proteins", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "83594": ["Nicotinamide salvaging"], "83595": ["Deactivation of the beta-catenin transactivating complex"], "83597": ["Olfactory Signaling Pathway"], "836": ["Activation of caspases through apoptosome-mediated cleavage", "SMAC (DIABLO) binds to IAPs ", "SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ", "Apoptotic cleavage of cellular proteins", "SMAC, XIAP-regulated apoptotic response", "Degradation of the extracellular matrix", "Signaling by Hippo", "NADE modulates death signalling", "Activation of DNA fragmentation factor", "Stimulation of the cell death response by PAK-2p34", "Caspase-mediated cleavage of cytoskeletal proteins", "Apoptotic cleavage of cell adhesion proteins", "Caspase activation via Dependence Receptors in the absence of ligand", "Caspase activation via Dependence Receptors in the absence of ligand", "Other interleukin signaling"], "8360": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "SUMOylation of chromatin organization proteins", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "8361": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "SUMOylation of chromatin organization proteins", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "8362": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "SUMOylation of chromatin organization proteins", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "8363": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "SUMOylation of chromatin organization proteins", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "83639": ["Post-translational modification: synthesis of GPI-anchored proteins"], "8364": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "SUMOylation of chromatin organization proteins", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "8365": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "SUMOylation of chromatin organization proteins", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "83657": ["Intraflagellar transport"], "83658": ["Intraflagellar transport"], "8366": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "SUMOylation of chromatin organization proteins", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "83666": ["Nicotinamide salvaging"], "83667": ["TP53 Regulates Metabolic Genes"], "8367": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "SUMOylation of chromatin organization proteins", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "8368": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "SUMOylation of chromatin organization proteins", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "83692": ["Cell surface interactions at the vascular wall"], "83695": ["HDR through Single Strand Annealing (SSA)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Regulation of TP53 Activity through Phosphorylation", "G2/M DNA damage checkpoint"], "83696": ["COPII-mediated vesicle transport", "RAB GEFs exchange GTP for GDP on RABs"], "83697": ["Bicarbonate transporters"], "837": ["NOD1/2 Signaling Pathway"], "8370": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "SUMOylation of chromatin organization proteins", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "83700": ["Cell surface interactions at the vascular wall", "Integrin cell surface interactions"], "83706": ["Platelet degranulation "], "83716": ["Neutrophil degranulation"], "8372": ["CS/DS degradation", "Hyaluronan uptake and degradation"], "83729": ["Glycoprotein hormones"], "83732": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "83733": ["Organic anion transporters"], "83734": ["Macroautophagy", "Macroautophagy"], "83737": ["Downregulation of ERBB4 signaling", "NOD1/2 Signaling Pathway", "Activated NOTCH1 Transmits Signal to the Nucleus", "Activated NOTCH1 Transmits Signal to the Nucleus", "Degradation of GLI1 by the proteasome", "Hedgehog 'on' state", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Negative regulators of DDX58/IFIH1 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "83741": ["Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "Activation of the TFAP2 (AP-2) family of transcription factors"], "83744": ["Generic Transcription Pathway"], "83746": ["SUMOylation of chromatin organization proteins", "Transcriptional Regulation by E2F6"], "83752": ["Association of TriC/CCT with target proteins during biosynthesis", "Peroxisomal protein import", "Peroxisomal protein import"], "83756": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "8379": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "83795": ["TWIK-related alkaline pH activated K+ channel (TALK)", "Phase 4 - resting membrane potential"], "8383": ["Olfactory Signaling Pathway"], "83844": ["Ub-specific processing proteases"], "83850": ["Glycosphingolipid metabolism"], "83852": ["PKMTs methylate histone lysines"], "83858": ["Neutrophil degranulation"], "8386": ["Olfactory Signaling Pathway"], "83860": ["HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "8387": ["Olfactory Signaling Pathway"], "83871": ["RAB geranylgeranylation"], "83874": ["TBC/RABGAPs"], "83875": ["Retinoid metabolism and transport"], "8388": ["Olfactory Signaling Pathway"], "83884": ["Urea cycle"], "83887": ["Carboxyterminal post-translational modifications of tubulin"], "83888": ["FGFR2b ligand binding and activation"], "83895": ["Keratinization"], "83896": ["Keratinization"], "83897": ["Keratinization"], "83899": ["Keratinization"], "839": ["Apoptotic cleavage of cellular proteins", "Caspase-mediated cleavage of cytoskeletal proteins", "Breakdown of the nuclear lamina", "TP53 Regulates Transcription of Caspase Activators and Caspases"], "8390": ["Olfactory Signaling Pathway"], "83900": ["Keratinization"], "83901": ["Keratinization"], "83902": ["Keratinization"], "8392": ["Olfactory Signaling Pathway"], "83930": ["Pregnenolone biosynthesis"], "83932": ["Translesion Synthesis by POLH"], "83933": ["NOTCH1 Intracellular Domain Regulates Transcription", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "HDACs deacetylate histones"], "8394": ["Synthesis of PIPs at the plasma membrane", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "8395": ["Synthesis of PIPs at the plasma membrane", "WNT mediated activation of DVL", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "83953": ["Cell surface interactions at the vascular wall"], "8396": ["Synthesis of PIPs at the plasma membrane", "PI5P Regulates TP53 Acetylation", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Synthesis of PIPs in the nucleus"], "8398": ["Acyl chain remodelling of PC", "Acyl chain remodeling of CL", "Acyl chain remodelling of PE", "Role of phospholipids in phagocytosis", "COPI-independent Golgi-to-ER retrograde traffic"], "83987": ["Neddylation"], "83988": ["Activation of Ca-permeable Kainate Receptor"], "8399": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PS", "Acyl chain remodelling of PE", "Acyl chain remodelling of PI", "Acyl chain remodelling of PG", "Synthesis of PA"], "83990": ["Cytosolic iron-sulfur cluster assembly", "HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Regulation of TP53 Activity through Phosphorylation", "G2/M DNA damage checkpoint"], "83999": ["TCF dependent signaling in response to WNT", "Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling"], "840": ["Activation of caspases through apoptosome-mediated cleavage", "SMAC (DIABLO) binds to IAPs ", "SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ", "Apoptotic cleavage of cellular proteins", "SMAC, XIAP-regulated apoptotic response", "Caspase-mediated cleavage of cytoskeletal proteins"], "84002": ["O-linked glycosylation of mucins"], "8402": ["Gluconeogenesis"], "84033": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "84034": ["Molecules associated with elastic fibres", "Molecules associated with elastic fibres"], "8404": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "8405": ["Hedgehog 'on' state"], "84057": ["Meiotic recombination"], "84061": ["Asparagine N-linked glycosylation", "Miscellaneous transport and binding events", "Neutrophil degranulation"], "84062": ["Golgi Associated Vesicle Biogenesis"], "84063": ["Nephrin family interactions"], "8407": ["Platelet degranulation "], "84078": ["Regulation of RAS by GAPs", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "84079": ["RAB GEFs exchange GTP for GDP on RABs"], "8408": ["Macroautophagy", "TBC/RABGAPs", "RAB GEFs exchange GTP for GDP on RABs", "Receptor Mediated Mitophagy"], "84085": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "8409": ["Transcriptional Regulation by E2F6"], "841": ["Apoptotic cleavage of cellular proteins", "Caspase activation via Death Receptors in the presence of ligand", "NOD1/2 Signaling Pathway", "TRIF-mediated programmed cell death", "Caspase-mediated cleavage of cytoskeletal proteins", "Regulation by c-FLIP", "RIPK1-mediated regulated necrosis", "CASP8 activity is inhibited", "TNFR1-induced proapoptotic signaling", "Regulation of TNFR1 signaling", "CLEC7A/inflammasome pathway", "Regulation of necroptotic cell death", "Dimerization of procaspase-8", "Activation, myristolyation of BID and translocation to mitochondria", "Apoptotic execution phase", "FasL/ CD95L signaling", "TRAIL signaling", "TLR3-mediated TICAM1-dependent programmed cell death", "NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10"], "84100": ["BBSome-mediated cargo-targeting to cilium"], "84101": ["Ub-specific processing proteases"], "84102": ["Metal ion SLC transporters"], "84108": ["Transcriptional Regulation by E2F6"], "84109": ["Orexin and neuropeptides FF and QRFP bind to their respective receptors", "G alpha (q) signalling events"], "8411": ["Toll Like Receptor 9 (TLR9) Cascade"], "84124": ["Generic Transcription Pathway"], "84126": ["Activation of ATR in response to replication stress", "HDR through Single Strand Annealing (SSA)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Fanconi Anemia Pathway", "Regulation of TP53 Activity through Phosphorylation", "G2/M DNA damage checkpoint"], "84128": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "84129": ["Mitochondrial Fatty Acid Beta-Oxidation"], "84131": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "84132": ["Ub-specific processing proteases"], "84133": ["Regulation of FZD by ubiquitination"], "84135": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "84141": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "84142": ["Metalloprotease DUBs", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "G2/M DNA damage checkpoint"], "84144": ["Rho GTPase cycle"], "84148": ["HATs acetylate histones"], "84152": ["DARPP-32 events", "DARPP-32 events"], "84159": ["HDMs demethylate histones"], "84164": ["ALKBH3 mediated reversal of alkylation damage"], "84166": ["DDX58/IFIH1-mediated induction of interferon-alpha/beta", "Negative regulators of DDX58/IFIH1 signaling"], "84168": ["Uptake and function of anthrax toxins"], "84171": ["Elastic fibre formation", "Crosslinking of collagen fibrils"], "84172": ["NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase I Transcription Termination"], "84188": ["Wax biosynthesis"], "84189": ["Receptor-type tyrosine-protein phosphatases"], "84193": ["PKMTs methylate histone lysines"], "84196": ["Ub-specific processing proteases"], "84197": ["O-linked glycosylation"], "842": ["Formation of apoptosome", "Activation of caspases through apoptosome-mediated cleavage", "SMAC (DIABLO) binds to IAPs ", "SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ", "NOD1/2 Signaling Pathway", "AKT phosphorylates targets in the cytosol", "Caspase activation via Dependence Receptors in the absence of ligand", "Constitutive Signaling by AKT1 E17K in Cancer", "Regulation of the apoptosome activity", "Regulation of the apoptosome activity"], "84230": ["Miscellaneous transport and binding events"], "84231": ["Antigen processing: Ubiquitination & Proteasome degradation"], "84232": ["Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription"], "84239": ["Ion transport by P-type ATPases"], "8424": ["Carnitine synthesis"], "84245": ["Methionine salvage pathway"], "84246": ["PPARA activates gene expression", "Generic Transcription Pathway", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "84248": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA 3'-end processing"], "8425": ["Molecules associated with elastic fibres"], "84251": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "84254": ["CaMK IV-mediated phosphorylation of CREB", "CaMK IV-mediated phosphorylation of CREB", "CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "Activation of RAC1 downstream of NMDARs", "Activation of RAC1 downstream of NMDARs"], "84259": ["Neddylation"], "84261": ["Association of TriC/CCT with target proteins during biosynthesis", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "84265": ["Cytosolic sensors of pathogen-associated DNA ", "RNA Polymerase III Chain Elongation", "RNA Polymerase III Transcription Termination", "RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "84269": ["Mitochondrial protein import"], "8427": ["Generic Transcription Pathway"], "84271": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA 3'-end processing"], "84274": ["Ubiquinol biosynthesis"], "84276": ["Carboxyterminal post-translational modifications of tubulin"], "8428": ["Apoptotic cleavage of cellular proteins", "Apoptotic execution phase"], "84282": ["DDX58/IFIH1-mediated induction of interferon-alpha/beta", "Ovarian tumor domain proteases", "TRAF3-dependent IRF activation pathway", "TRAF6 mediated IRF7 activation", "TRAF6 mediated NF-kB activation", "TRAF6 mediated NF-kB activation", "NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10", "Negative regulators of DDX58/IFIH1 signaling", "Negative regulators of DDX58/IFIH1 signaling"], "84289": ["HATs acetylate histones", "Regulation of TP53 Activity through Acetylation"], "84290": ["Degradation of the extracellular matrix", "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models"], "84292": ["MAP2K and MAPK activation"], "84296": ["Unwinding of DNA", "Unwinding of DNA"], "843": ["TP53 Regulates Transcription of Caspase Activators and Caspases", "FasL/ CD95L signaling", "TRAIL signaling", "NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10"], "84303": ["Cristae formation"], "8431": ["Nuclear Receptor transcription pathway"], "84313": ["Endosomal Sorting Complex Required For Transport (ESCRT)"], "84315": ["RAB GEFs exchange GTP for GDP on RABs"], "84316": ["Retrograde transport at the Trans-Golgi-Network"], "84320": ["Mitochondrial Fatty Acid Beta-Oxidation"], "84321": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA 3'-end processing"], "84324": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA 3'-end processing"], "84329": ["ROS, RNS production in phagocytes", "Sperm Motility And Taxes", "Neutrophil degranulation"], "84333": ["RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "84335": ["mTOR signalling", "mTORC1-mediated signalling", "AKT phosphorylates targets in the cytosol", "HSF1-dependent transactivation", "Constitutive Signaling by AKT1 E17K in Cancer"], "8434": ["Post-translational modification: synthesis of GPI-anchored proteins"], "84340": ["Mitochondrial translation termination"], "84342": ["COPI-mediated anterograde transport", "Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network"], "8435": ["LDL clearance"], "84364": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "8437": ["Regulation of RAS by GAPs", "Signaling by RAS mutants"], "8439": ["TNFR1-mediated ceramide production"], "844": ["Stimuli-sensing channels", "Ion homeostasis"], "8440": ["Downstream signal transduction", "Nephrin family interactions", "Ephrin signaling", "Activation of RAC1", "VEGFA-VEGFR2 Pathway", "Regulation of cortical dendrite branching"], "84418": ["Neutrophil degranulation"], "8443": ["Synthesis of PA", "Plasmalogen biosynthesis", "Peroxisomal protein import", "Peroxisomal protein import"], "84432": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "84433": ["Activation of NF-kappaB in B cells", "Activation of NF-kappaB in B cells", "Downstream TCR signaling", "FCERI mediated NF-kB activation", "FCERI mediated NF-kB activation", "CLEC7A (Dectin-1) signaling"], "84436": ["Generic Transcription Pathway"], "84441": ["Pre-NOTCH Transcription and Translation", "Pre-NOTCH Transcription and Translation", "Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "NOTCH1 Intracellular Domain Regulates Transcription", "NOTCH1 Intracellular Domain Regulates Transcription", "NOTCH2 intracellular domain regulates transcription", "NOTCH2 intracellular domain regulates transcription", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "Notch-HLH transcription pathway", "RUNX3 regulates NOTCH signaling", "RUNX3 regulates NOTCH signaling", "NOTCH3 Intracellular Domain Regulates Transcription", "NOTCH3 Intracellular Domain Regulates Transcription", "NOTCH4 Intracellular Domain Regulates Transcription", "NOTCH4 Intracellular Domain Regulates Transcription"], "84443": ["Neutrophil degranulation"], "84444": ["PKMTs methylate histone lysines"], "84447": ["XBP1(S) activates chaperone genes", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "ER Quality Control Compartment (ERQC)"], "84448": ["DCC mediated attractive signaling"], "84449": ["Generic Transcription Pathway"], "8445": ["Regulation of TP53 Activity through Phosphorylation"], "84455": ["Activation of SMO"], "84464": ["Resolution of D-loop Structures through Holliday Junction Intermediates", "Fanconi Anemia Pathway"], "84467": ["Degradation of the extracellular matrix", "Elastic fibre formation", "Molecules associated with elastic fibres", "Molecules associated with elastic fibres"], "8449": ["mRNA Splicing - Major Pathway"], "84498": ["PPARA activates gene expression", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "845": ["Stimuli-sensing channels", "Ion homeostasis"], "8450": ["Recognition of DNA damage by PCNA-containing replication complex", "DNA Damage Recognition in GG-NER", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Neddylation"], "8451": ["Recognition of DNA damage by PCNA-containing replication complex", "DNA Damage Recognition in GG-NER", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Neddylation"], "84513": ["Role of phospholipids in phagocytosis"], "84514": ["Neutrophil degranulation"], "84515": ["E2F-enabled inhibition of pre-replication complex formation", "Activation of ATR in response to replication stress", "Unwinding of DNA", "CDC6 association with the ORC:origin complex", "CDT1 association with the CDC6:ORC:origin complex", "Assembly of the pre-replicative complex", "Orc1 removal from chromatin", "Activation of the pre-replicative complex"], "84516": ["MHC class II antigen presentation", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic"], "8452": ["Degradation of DVL", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "84524": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes"], "84527": ["Generic Transcription Pathway"], "8453": ["Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Antigen processing: Ubiquitination & Proteasome degradation"], "84532": ["Ethanol oxidation"], "84539": ["Peptide ligand-binding receptors", "G alpha (q) signalling events", "G alpha (i) signalling events"], "8454": ["Activation of NF-kappaB in B cells", "Prolactin receptor signaling", "SCF-beta-TrCP mediated degradation of Emi1", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "NOTCH1 Intracellular Domain Regulates Transcription", "Regulation of PLK1 Activity at G2/M Transition", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling", "FCERI mediated NF-kB activation", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "Circadian Clock", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "NIK-->noncanonical NF-kB signaling", "MAP3K8 (TPL2)-dependent MAPK1/3 activation", "Orc1 removal from chromatin", "Cyclin D associated events in G1", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Neddylation", "Interleukin-1 signaling", "Iron uptake and transport", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "84541": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "84545": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "84552": ["Tight junction interactions"], "84557": ["Macroautophagy", "Pink/Parkin Mediated Mitophagy", "Receptor Mediated Mitophagy"], "84560": ["Metallothioneins bind metals"], "84570": ["Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Collagen chain trimerization"], "8459": ["Cytosolic sulfonation of small molecules"], "846": ["G alpha (q) signalling events", "G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "8460": ["Cytosolic sulfonation of small molecules"], "84612": ["Tight junction interactions"], "84616": ["Keratinization"], "84617": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "Gap junction assembly", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Recruitment of NuMA to mitotic centrosomes", "Prefoldin mediated transfer of substrate to CCT/TriC", "Formation of tubulin folding intermediates by CCT/TriC", "Post-chaperonin tubulin folding pathway", "Recycling pathway of L1", "Recycling pathway of L1", "Hedgehog 'off' state", "Cilium Assembly", "Intraflagellar transport", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "Carboxyterminal post-translational modifications of tubulin", "Carboxyterminal post-translational modifications of tubulin", "Activation of AMPK downstream of NMDARs", "Kinesins"], "84618": ["Pyrimidine catabolism", "Purine catabolism"], "84620": ["Sialic acid metabolism"], "84623": ["Nephrin family interactions"], "84626": ["Generic Transcription Pathway"], "84628": ["Post-translational modification: synthesis of GPI-anchored proteins"], "8463": ["YAP1- and WWTR1 (TAZ)-stimulated gene expression", "RUNX3 regulates YAP1-mediated transcription"], "84631": ["Receptor-type tyrosine-protein phosphatases"], "84634": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "84639": ["Interleukin-38 signaling", "Interleukin-36 pathway"], "8464": ["HATs acetylate histones"], "84643": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "COPI-dependent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "Kinesins"], "84648": ["Formation of the cornified envelope"], "84649": ["Acyl chain remodeling of DAG and TAG", "Triglyceride biosynthesis"], "84658": ["Class B/2 (Secretin family receptors)", "Neutrophil degranulation"], "84659": ["Antimicrobial peptides"], "84661": ["PKMTs methylate histone lysines", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"], "8467": ["NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Deposition of new CENPA-containing nucleosomes at the centromere"], "84671": ["Generic Transcription Pathway"], "84676": ["FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "Antigen processing: Ubiquitination & Proteasome degradation"], "84678": ["HDMs demethylate histones"], "84679": ["Sodium/Proton exchangers"], "8468": ["Meiotic synapsis", "PIWI-interacting RNA (piRNA) biogenesis"], "84693": ["Propionyl-CoA catabolism"], "84694": ["Electric Transmission Across Gap Junctions", "Gap junction assembly"], "84695": ["Elastic fibre formation", "Crosslinking of collagen fibrils"], "84699": ["CREB3 factors activate genes", "Assembly of active LPL and LIPC lipase complexes"], "847": ["Detoxification of Reactive Oxygen Species", "Neutrophil degranulation", "Peroxisomal protein import", "Peroxisomal protein import", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes"], "84705": ["tRNA modification in the mitochondrion"], "84706": ["Amino acid synthesis and interconversion (transamination)"], "84708": ["Antigen processing: Ubiquitination & Proteasome degradation"], "8471": ["IRS-related events triggered by IGF1R"], "84720": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "84725": ["Synthesis of PIPs at the plasma membrane"], "84727": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "8473": ["HATs acetylate histones", "UCH proteinases"], "84733": ["Oxidative Stress Induced Senescence", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of transcription cofactors", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA methylation proteins", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription"], "84747": ["Trafficking of myristoylated proteins to the cilium"], "84749": ["Ub-specific processing proteases"], "84752": ["O-linked glycosylation of mucins"], "84765": ["Generic Transcription Pathway"], "84766": ["Neutrophil degranulation"], "8477": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (q) signalling events"], "84775": ["Generic Transcription Pathway"], "84787": ["PKMTs methylate histone lysines"], "84790": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "Gap junction assembly", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Recruitment of NuMA to mitotic centrosomes", "Prefoldin mediated transfer of substrate to CCT/TriC", "Formation of tubulin folding intermediates by CCT/TriC", "Post-chaperonin tubulin folding pathway", "Recycling pathway of L1", "Recycling pathway of L1", "Hedgehog 'off' state", "Cilium Assembly", "Intraflagellar transport", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "Carboxyterminal post-translational modifications of tubulin", "Carboxyterminal post-translational modifications of tubulin", "Activation of AMPK downstream of NMDARs", "Kinesins"], "8480": ["ISG15 antiviral mechanism", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "tRNA processing in the nucleus"], "84803": ["Synthesis of PA"], "84808": ["Transcriptional activation of mitochondrial biogenesis"], "8481": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Hedgehog 'off' state", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "84812": ["Synthesis of IP3 and IP4 in the cytosol"], "84818": ["Interleukin-17 signaling"], "8482": ["Other semaphorin interactions", "Other semaphorin interactions"], "8483": ["Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)"], "84836": ["Cytosolic sulfonation of small molecules"], "84838": ["Generic Transcription Pathway"], "8484": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "84844": ["mRNA Splicing - Major Pathway"], "84861": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "84864": ["HDMs demethylate histones"], "84867": ["Interleukin-37 signaling"], "84868": ["Interleukin-2 family signaling"], "84869": ["Fatty acyl-CoA biosynthesis"], "8487": ["snRNP Assembly"], "84870": ["Regulation of FZD by ubiquitination", "RUNX1 regulates transcription of genes involved in WNT signaling"], "84871": ["Carboxyterminal post-translational modifications of tubulin"], "84874": ["Generic Transcription Pathway"], "84875": ["Nicotinamide salvaging"], "84876": ["Elevation of cytosolic Ca2+ levels", "Ion homeostasis", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "84879": ["Synthesis of PC"], "84883": ["TP53 Regulates Transcription of Genes Involved in Cytochrome C Release"], "84888": ["Regulation of TNFR1 signaling"], "84889": ["Amino acid transport across the plasma membrane"], "84890": ["Degradation of cysteine and homocysteine"], "84891": ["Transcriptional regulation of pluripotent stem cells"], "84892": ["O-linked glycosylation"], "84894": ["Axonal growth inhibition (RHOA activation)"], "84895": ["Synthesis of PA"], "8490": ["G alpha (q) signalling events", "G alpha (i) signalling events", "G alpha (i) signalling events"], "84902": ["Anchoring of the basal body to the plasma membrane"], "84904": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "84909": ["Metabolism of Angiotensinogen to Angiotensins"], "84911": ["Generic Transcription Pathway"], "84912": ["Transport of nucleotide sugars"], "84914": ["Generic Transcription Pathway"], "84916": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "84920": ["Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"], "84924": ["Generic Transcription Pathway"], "8493": ["Transcriptional regulation by RUNX2"], "84930": ["MASTL Facilitates Mitotic Progression", "MASTL Facilitates Mitotic Progression"], "84932": ["RAB geranylgeranylation"], "84937": ["Antigen processing: Ubiquitination & Proteasome degradation"], "84938": ["Macroautophagy"], "84944": ["PIWI-interacting RNA (piRNA) biogenesis"], "84946": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "8495": ["Receptor-type tyrosine-protein phosphatases"], "84950": ["mRNA Splicing - Major Pathway"], "84951": ["MET interacts with TNS proteins"], "84958": ["TBC/RABGAPs"], "8496": ["Receptor-type tyrosine-protein phosphatases"], "84961": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "84962": ["Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Regulation of PLK1 Activity at G2/M Transition", "Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "84967": ["Cleavage of Growing Transcript in the Termination Region ", "SLBP independent Processing of Histone Pre-mRNAs", "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"], "8497": ["Serotonin Neurotransmitter Release Cycle", "Norepinephrine Neurotransmitter Release Cycle", "Glutamate Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle", "Acetylcholine Neurotransmitter Release Cycle", "Receptor-type tyrosine-protein phosphatases"], "84971": ["Macroautophagy"], "84986": ["Rho GTPase cycle"], "84987": ["TP53 Regulates Metabolic Genes", "Respiratory electron transport"], "8499": ["Serotonin Neurotransmitter Release Cycle", "Norepinephrine Neurotransmitter Release Cycle", "Glutamate Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle", "Acetylcholine Neurotransmitter Release Cycle", "Receptor-type tyrosine-protein phosphatases"], "84991": ["mRNA Splicing - Major Pathway"], "84992": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "8500": ["Serotonin Neurotransmitter Release Cycle", "Norepinephrine Neurotransmitter Release Cycle", "Glutamate Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle", "Acetylcholine Neurotransmitter Release Cycle", "Receptor-type tyrosine-protein phosphatases"], "85007": ["Collagen degradation", "Lysine catabolism"], "8501": ["Amino acid transport across the plasma membrane"], "85015": ["Formation of Incision Complex in GG-NER"], "8502": ["Keratinization", "Formation of the cornified envelope"], "85021": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "8503": ["GPVI-mediated activation cascade", "PIP3 activates AKT signaling", "Interleukin-7 signaling", "Interleukin-7 signaling", "Signaling by SCF-KIT", "Synthesis of PIPs at the plasma membrane", "Constitutive Signaling by Aberrant PI3K in Cancer", "Costimulation by the CD28 family", "CD28 dependent PI3K/Akt signaling", "G alpha (q) signalling events", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "RET signaling", "Interleukin receptor SHC signaling", "Regulation of signaling by CBL", "Regulation of signaling by CBL"], "8504": ["ABC transporters in lipid homeostasis"], "8505": ["POLB-Dependent Long Patch Base Excision Repair"], "8506": ["Neurofascin interactions"], "850642": ["TP53 Regulates Metabolic Genes", "Respiratory electron transport"], "8509": ["HS-GAG biosynthesis"], "8513": ["Digestion of dietary lipid"], "8514": ["Voltage gated Potassium channels", "Neutrophil degranulation"], "8515": ["Integrin cell surface interactions", "Integrin cell surface interactions", "CHL1 interactions", "Platelet Adhesion to exposed collagen"], "8516": ["Molecules associated with elastic fibres", "Integrin cell surface interactions", "Integrin cell surface interactions", "ECM proteoglycans"], "8517": ["Activation of NF-kappaB in B cells", "Activation of NF-kappaB in B cells", "ER-Phagosome pathway", "NOD1/2 Signaling Pathway", "TICAM1, RIP1-mediated IKK complex recruitment ", "RIP-mediated NFkB activation via ZBP1", "Downstream TCR signaling", "FCERI mediated NF-kB activation", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "activated TAK1 mediates p38 MAPK activation", "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "SUMOylation of immune response proteins", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "IKBKB deficiency causes SCID", "IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)", "IkBA variant leads to EDA-ID", "CLEC7A (Dectin-1) signaling", "MAP3K8 (TPL2)-dependent MAPK1/3 activation", "Ub-specific processing proteases", "Ovarian tumor domain proteases", "Interleukin-1 signaling", "TRAF6 mediated NF-kB activation", "NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10", "IRAK1 recruits IKK complex", "IKK complex recruitment mediated by RIP1", "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation"], "8518": ["HATs acetylate histones"], "8519": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon alpha/beta signaling"], "8520": ["HATs acetylate histones"], "85235": ["HDACs deacetylate histones", "HATs acetylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "UCH proteinases", "Ub-specific processing proteases", "Metalloprotease DUBs"], "85236": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "HATs acetylate histones", "HATs acetylate histones", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Ub-specific processing proteases", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "E3 ubiquitin ligases ubiquitinate target proteins", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "8525": ["Effects of PIP2 hydrolysis"], "8526": ["Effects of PIP2 hydrolysis"], "8527": ["Effects of PIP2 hydrolysis"], "8528": ["Glyoxylate metabolism and glycine degradation", "Peroxisomal protein import", "Peroxisomal protein import"], "85280": ["Keratinization"], "85285": ["Keratinization"], "85289": ["Keratinization"], "8529": ["Fatty acids", "Miscellaneous substrates", "Eicosanoids", "Synthesis of Leukotrienes (LT) and Eoxins (EX)", "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)"], "85290": ["Keratinization"], "85291": ["Keratinization"], "85293": ["Keratinization"], "85294": ["Keratinization"], "85301": ["Collagen biosynthesis and modifying enzymes", "Assembly of collagen fibrils and other multimeric structures", "MET activates PTK2 signaling", "Collagen chain trimerization"], "85302": ["Anchoring of the basal body to the plasma membrane"], "85313": ["mRNA Splicing - Major Pathway"], "85320": ["ABC-family proteins mediated transport"], "8533": ["DNA Damage Recognition in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Cargo recognition for clathrin-mediated endocytosis", "Neddylation"], "8534": ["Keratan sulfate biosynthesis"], "8535": ["Oxidative Stress Induced Senescence", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of transcription cofactors", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA methylation proteins", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription"], "85358": ["Neurexins and neuroligins", "Neurexins and neuroligins", "RET signaling"], "8536": ["Negative regulation of NMDA receptor-mediated neuronal transmission", "Activation of RAC1 downstream of NMDARs", "Activation of RAC1 downstream of NMDARs"], "85360": ["Rho GTPase cycle"], "85363": ["Interferon gamma signaling"], "85365": ["Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "Defective ALG2 causes ALG2-CDG (CDG-1i)"], "85378": ["Recruitment of mitotic centrosome proteins and complexes", "Recruitment of NuMA to mitotic centrosomes"], "85397": ["G alpha (i) signalling events", "G alpha (i) signalling events"], "8540": ["Plasmalogen biosynthesis", "Peroxisomal protein import", "Peroxisomal protein import", "TYSND1 cleaves peroxisomal proteins"], "85403": ["Formation of RNA Pol II elongation complex ", "RNA Polymerase II Pre-transcription Events", "RNA Polymerase II Transcription Elongation"], "8541": ["Serotonin Neurotransmitter Release Cycle", "Norepinephrine Neurotransmitter Release Cycle", "Glutamate Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle", "Acetylcholine Neurotransmitter Release Cycle", "Receptor-type tyrosine-protein phosphatases"], "85413": ["Organic cation transport"], "85414": ["Cellular hexose transport"], "85415": ["RHO GTPases Activate Rhotekin and Rhophilins", "RHO GTPases Activate Rhotekin and Rhophilins"], "8542": ["Scavenging of heme from plasma", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "85437": ["mRNA Splicing - Minor Pathway"], "85439": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "8544": ["Digestion"], "85440": ["MET activates RAP1 and RAC1", "Factors involved in megakaryocyte development and platelet production"], "85441": ["RORA activates gene expression", "BMAL1:CLOCK,NPAS2 activates circadian gene expression", "PPARA activates gene expression", "PPARA activates gene expression", "Transcriptional activation of mitochondrial biogenesis", "Activation of gene expression by SREBF (SREBP)", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)", "Circadian Clock"], "85455": ["Release of Hh-Np from the secreting cell", "Release of Hh-Np from the secreting cell"], "85456": ["Deadenylation of mRNA", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "8546": ["Golgi Associated Vesicle Biogenesis", "Signaling by BRAF and RAF fusions"], "85465": ["Synthesis of PE"], "8547": ["Lectin pathway of complement activation", "Initial triggering of complement", "Ficolins bind to repetitive carbohydrate structures on the target cell surface"], "85476": ["Mitochondrial translation elongation", "Mitochondrial translation elongation"], "8548": ["Golgi Cisternae Pericentriolar Stack Reorganization"], "85480": ["Interleukin-7 signaling", "Interleukin-7 signaling"], "8549": ["Regulation of FZD by ubiquitination"], "8550": ["Oxidative Stress Induced Senescence", "MAPK6/MAPK4 signaling", "Regulation of TP53 Activity through Phosphorylation"], "8553": ["BMAL1:CLOCK,NPAS2 activates circadian gene expression"], "8554": ["SUMOylation of DNA damage response and repair proteins", "SUMOylation of transcription factors", "SUMOylation of ubiquitinylation proteins", "SUMOylation of transcription cofactors", "SUMOylation of intracellular receptors", "SUMOylation of intracellular receptors", "SUMOylation of chromatin organization proteins", "Formation of Incision Complex in GG-NER", "Regulation of IFNG signaling"], "8555": ["MAPK6/MAPK4 signaling"], "8556": ["Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "MAPK6/MAPK4 signaling"], "8557": ["Striated Muscle Contraction"], "8560": ["Sphingolipid de novo biosynthesis", "Neutrophil degranulation"], "8563": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA 3'-end processing"], "8564": ["Tryptophan catabolism"], "8565": ["Cytosolic tRNA aminoacylation"], "8566": ["Neutrophil degranulation", "Vitamins B6 activation to pyridoxal phosphate"], "8567": ["Regulation of TNFR1 signaling", "RAB GEFs exchange GTP for GDP on RABs"], "8568": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "8569": ["Spry regulation of FGF signaling"], "857": ["Triglyceride catabolism", "eNOS activation", "NOSTRIN mediated eNOS trafficking", "Basigin interactions", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "VEGFR2 mediated vascular permeability", "FOXO-mediated transcription of cell cycle genes"], "8570": ["ATF4 activates genes", "KSRP (KHSRP) binds and destabilizes mRNA", "KSRP (KHSRP) binds and destabilizes mRNA"], "8573": ["Dopamine Neurotransmitter Release Cycle", "Syndecan interactions", "Nephrin family interactions", "Neurexins and neuroligins", "Neurexins and neuroligins"], "8574": ["Aflatoxin activation and detoxification"], "8575": ["MicroRNA (miRNA) biogenesis", "Small interfering RNA (siRNA) biogenesis"], "8578": ["Scavenging by Class F Receptors", "Scavenging by Class F Receptors"], "8581": ["Post-translational modification: synthesis of GPI-anchored proteins"], "859": ["Smooth Muscle Contraction", "Smooth Muscle Contraction"], "8590": ["Olfactory Signaling Pathway"], "86": ["HATs acetylate histones", "RMTs methylate histone arginines", "UCH proteinases", "DNA Damage Recognition in GG-NER", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "860": ["YAP1- and WWTR1 (TAZ)-stimulated gene expression", "Transcriptional regulation by RUNX2", "Transcriptional regulation by RUNX2", "RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "RUNX2 regulates osteoblast differentiation", "RUNX2 regulates osteoblast differentiation", "RUNX2 regulates chondrocyte maturation", "RUNX2 regulates bone development", "RUNX2 regulates genes involved in cell migration", "RUNX2 regulates genes involved in cell migration", "RUNX2 regulates genes involved in differentiation of myeloid cells"], "8600": ["TNFR2 non-canonical NF-kB pathway", "TNFs bind their physiological receptors", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "8601": ["G alpha (i) signalling events", "G alpha (i) signalling events", "G alpha (z) signalling events", "G alpha (z) signalling events"], "8602": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "8604": ["Mitochondrial protein import", "Gluconeogenesis"], "8605": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PE", "Acyl chain remodelling of PI", "Hydrolysis of LPC", "Hydrolysis of LPE"], "8607": ["Telomere Extension By Telomerase", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "HATs acetylate histones", "UCH proteinases", "Ub-specific processing proteases", "DNA Damage Recognition in GG-NER", "Deposition of new CENPA-containing nucleosomes at the centromere"], "8608": ["The canonical retinoid cycle in rods (twilight vision)", "RA biosynthesis pathway"], "861": ["Pre-NOTCH Transcription and Translation", "Organic cation transport", "RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "RUNX1 regulates estrogen receptor mediated transcription", "Regulation of RUNX1 Expression and Activity", "Regulation of RUNX1 Expression and Activity", "RUNX1 regulates expression of components of tight junctions", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "RUNX1 regulates transcription of genes involved in differentiation of keratinocytes", "RUNX1 regulates transcription of genes involved in differentiation of keratinocytes", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "RUNX1 regulates transcription of genes involved in BCR signaling", "RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "RUNX1 regulates transcription of genes involved in interleukin signaling", "RUNX1 regulates transcription of genes involved in WNT signaling", "RUNX2 regulates genes involved in differentiation of myeloid cells", "RUNX3 regulates p14-ARF", "Estrogen-dependent gene expression"], "8611": ["Sphingolipid de novo biosynthesis"], "8612": ["Sphingolipid de novo biosynthesis"], "8613": ["Sphingolipid de novo biosynthesis"], "8614": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "8615": ["Golgi Cisternae Pericentriolar Stack Reorganization", "COPII-mediated vesicle transport", "COPI-mediated anterograde transport"], "8620": ["Orexin and neuropeptides FF and QRFP bind to their respective receptors", "G alpha (q) signalling events"], "8621": ["TP53 Regulates Transcription of DNA Repair Genes", "Neutrophil degranulation"], "8622": ["G alpha (s) signalling events"], "8626": ["Activation of PUMA and translocation to mitochondria", "TP53 Regulates Metabolic Genes", "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "TP53 Regulates Transcription of Caspase Activators and Caspases", "TP53 Regulates Transcription of Death Receptors and Ligands", "Regulation of TP53 Activity through Association with Co-factors"], "8630": ["The canonical retinoid cycle in rods (twilight vision)"], "8633": ["Netrin mediated repulsion signals"], "8635": ["Neutrophil degranulation"], "8636": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "8638": ["Interferon gamma signaling", "OAS antiviral response", "Interferon alpha/beta signaling"], "8639": ["Phase I - Functionalization of compounds"], "864": ["Binding of TCF/LEF:CTNNB1 to target gene promoters", "RUNX3 regulates CDKN1A transcription", "RUNX3 regulates NOTCH signaling", "Regulation of RUNX3 expression and activity", "RUNX3 Regulates Immune Response and Cell Migration", "RUNX3 Regulates Immune Response and Cell Migration", "RUNX3 regulates WNT signaling", "RUNX3 regulates YAP1-mediated transcription", "RUNX3 regulates RUNX1-mediated transcription", "RUNX3 regulates p14-ARF", "RUNX3 regulates BCL2L11 (BIM) transcription"], "8643": ["Class B/2 (Secretin family receptors)"], "8644": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of bile acids and bile salts via 24-hydroxycholesterol", "Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "RA biosynthesis pathway", "Retinoid metabolism and transport"], "8645": ["Phase 4 - resting membrane potential"], "8647": ["Recycling of bile acids and salts", "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Defective ABCB11 causes progressive familial intrahepatic cholestasis 2 and benign recurrent intrahepatic cholestasis 2"], "8648": ["RORA activates gene expression", "BMAL1:CLOCK,NPAS2 activates circadian gene expression", "Recycling of bile acids and salts", "Synthesis of bile acids and bile salts", "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "PPARA activates gene expression", "PPARA activates gene expression", "Endogenous sterols", "Transcriptional activation of mitochondrial biogenesis", "Activation of gene expression by SREBF (SREBP)", "HATs acetylate histones", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation", "SUMOylation of transcription cofactors", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)", "Circadian Clock", "Estrogen-dependent gene expression"], "8649": ["Macroautophagy", "mTOR signalling", "mTORC1-mediated signalling", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "MAP2K and MAPK activation", "Neutrophil degranulation", "Regulation of PTEN gene transcription"], "865": ["RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "Transcriptional regulation by RUNX2", "Transcriptional regulation by RUNX2", "RUNX1 regulates estrogen receptor mediated transcription", "Regulation of RUNX1 Expression and Activity", "RUNX1 regulates expression of components of tight junctions", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "RUNX1 regulates transcription of genes involved in differentiation of keratinocytes", "RUNX1 regulates transcription of genes involved in differentiation of keratinocytes", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "RUNX1 regulates transcription of genes involved in BCR signaling", "RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "RUNX1 regulates transcription of genes involved in interleukin signaling", "RUNX1 regulates transcription of genes involved in WNT signaling", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "RUNX2 regulates osteoblast differentiation", "RUNX2 regulates osteoblast differentiation", "RUNX2 regulates chondrocyte maturation", "RUNX2 regulates bone development", "RUNX2 regulates genes involved in cell migration", "RUNX2 regulates genes involved in cell migration", "RUNX2 regulates genes involved in differentiation of myeloid cells", "Regulation of RUNX3 expression and activity", "RUNX3 Regulates Immune Response and Cell Migration", "RUNX3 Regulates Immune Response and Cell Migration", "RUNX3 regulates RUNX1-mediated transcription", "RUNX3 regulates p14-ARF", "Estrogen-dependent gene expression"], "8650": ["Activated NOTCH1 Transmits Signal to the Nucleus", "Recycling pathway of L1", "Degradation of GLI1 by the proteasome", "Hedgehog 'on' state"], "8651": ["Interleukin-7 signaling", "Regulation of KIT signaling", "MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "Interleukin-4 and Interleukin-13 signaling", "Interferon gamma signaling", "Regulation of IFNG signaling", "Interferon alpha/beta signaling", "Regulation of IFNA signaling", "Growth hormone receptor signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "8654": ["cGMP effects"], "8655": ["Activation of BIM and translocation to mitochondria ", "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Macroautophagy", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Regulation of PLK1 Activity at G2/M Transition", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "Intraflagellar transport", "RHO GTPases Activate Formins", "Neutrophil degranulation", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "AURKA Activation by TPX2"], "8658": ["TCF dependent signaling in response to WNT", "Degradation of AXIN", "XAV939 inhibits tankyrase, stabilizing AXIN", "Ub-specific processing proteases", "Regulation of PTEN stability and activity"], "8659": ["Glyoxylate metabolism and glycine degradation", "Proline catabolism"], "8660": ["PI3K Cascade", "IRS-mediated signalling", "SOS-mediated signalling", "SOS-mediated signalling", "PIP3 activates AKT signaling", "Interleukin-7 signaling", "PI3K/AKT activation", "PI3K/AKT activation", "Constitutive Signaling by Aberrant PI3K in Cancer", "IRS-related events triggered by IGF1R", "Signaling by Leptin", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "IRS activation", "Signal attenuation", "RET signaling", "Signaling by Erythropoietin", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "Erythropoietin activates Phospholipase C gamma (PLCG)", "Erythropoietin activates STAT5", "Erythropoietin activates RAS", "Erythropoietin activates RAS", "Growth hormone receptor signaling"], "8661": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "8662": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "8663": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "8664": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "8665": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "8666": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "8667": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "8668": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "8669": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "867": ["Interleukin-6 signaling", "Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "Spry regulation of FGF signaling", "Regulation of KIT signaling", "EGFR downregulation", "TGF-beta receptor signaling activates SMADs", "Constitutive Signaling by EGFRvIII", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "Negative regulation of MET activity", "PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "InlB-mediated entry of Listeria monocytogenes into host cell", "InlB-mediated entry of Listeria monocytogenes into host cell", "Regulation of signaling by CBL", "Regulation of signaling by CBL"], "8671": ["Bicarbonate transporters", "Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)"], "8672": ["ISG15 antiviral mechanism"], "8673": ["ER-Phagosome pathway", "Clathrin derived vesicle budding", "Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis", "Neutrophil degranulation", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "8674": ["Retrograde transport at the Trans-Golgi-Network", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "8675": ["Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network"], "8677": ["Retrograde transport at the Trans-Golgi-Network"], "8678": ["Macroautophagy", "Ub-specific processing proteases"], "868": ["Antigen processing: Ubiquitination & Proteasome degradation"], "8681": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PS", "Acyl chain remodelling of PE", "Acyl chain remodelling of PG", "Hydrolysis of LPC", "Synthesis of PA", "XBP1(S) activates chaperone genes"], "8682": ["RAF-independent MAPK1/3 activation", "RAF/MAP kinase cascade"], "8683": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing"], "8685": ["Scavenging by Class A Receptors", "Scavenging by Class A Receptors"], "8687": ["Keratinization", "Formation of the cornified envelope"], "8688": ["Keratinization", "Formation of the cornified envelope"], "8689": ["Keratinization", "Formation of the cornified envelope"], "8692": ["Hyaluronan uptake and degradation"], "8693": ["O-linked glycosylation of mucins"], "8694": ["Acyl chain remodeling of DAG and TAG", "Neutrophil degranulation", "Triglyceride biosynthesis"], "8697": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6", "Antigen processing: Ubiquitination & Proteasome degradation"], "8698": ["G alpha (i) signalling events", "Lysosphingolipid and LPA receptors"], "87": ["Platelet degranulation ", "Syndecan interactions", "Nephrin family interactions", "Regulation of cytoskeletal remodeling and cell spreading by IPP complex components"], "8702": ["Keratan sulfate biosynthesis", "N-Glycan antennae elongation"], "8703": ["Keratan sulfate biosynthesis", "N-Glycan antennae elongation"], "8704": ["Keratan sulfate biosynthesis", "N-Glycan antennae elongation"], "8706": ["Glycosphingolipid metabolism"], "871": ["Collagen biosynthesis and modifying enzymes"], "8714": ["Recycling of bile acids and salts", "ABC-family proteins mediated transport"], "8717": ["Caspase activation via Death Receptors in the presence of ligand", "Regulation by c-FLIP", "RIPK1-mediated regulated necrosis", "CASP8 activity is inhibited", "TNFR1-induced proapoptotic signaling", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "Regulation of necroptotic cell death", "Dimerization of procaspase-8", "TNF signaling"], "8718": ["TNFs bind their physiological receptors"], "8720": ["Regulation of cholesterol biosynthesis by SREBP (SREBF)", "ATF6 (ATF6-alpha) activates chaperones", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "CREB3 factors activate genes", "CREB3 factors activate genes", "Post-translational protein phosphorylation", "Assembly of active LPL and LIPC lipase complexes"], "8722": ["MHC class II antigen presentation"], "8724": ["WNT ligand biogenesis and trafficking", "Ub-specific processing proteases"], "8726": ["PRC2 methylates histones and DNA", "Oxidative Stress Induced Senescence", "PKMTs methylate histone lysines", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription", "Transcriptional Regulation by E2F6"], "8728": ["Invadopodia formation"], "8729": ["Clathrin derived vesicle budding", "VxPx cargo-targeting to cilium", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "873": ["Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"], "8731": ["RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "mRNA Capping", "RNA Pol II CTD phosphorylation and interaction with CE"], "8732": ["RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "mRNA Capping", "RNA Pol II CTD phosphorylation and interaction with CE"], "8733": ["Attachment of GPI anchor to uPAR"], "8737": ["Caspase activation via Death Receptors in the presence of ligand", "TICAM1, RIP1-mediated IKK complex recruitment ", "RIP-mediated NFkB activation via ZBP1", "TRIF-mediated programmed cell death", "TRP channels", "Regulation by c-FLIP", "RIPK1-mediated regulated necrosis", "CASP8 activity is inhibited", "TNFR1-induced proapoptotic signaling", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "Regulation of necroptotic cell death", "Ub-specific processing proteases", "Ovarian tumor domain proteases", "Dimerization of procaspase-8", "TNF signaling", "TLR3-mediated TICAM1-dependent programmed cell death", "NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10", "IKK complex recruitment mediated by RIP1"], "8738": ["TP53 Regulates Transcription of Caspase Activators and Caspases"], "874": ["Phase I - Functionalization of compounds"], "8740": ["TNFR2 non-canonical NF-kB pathway", "TNFs bind their physiological receptors", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "8741": ["HuR (ELAVL1) binds and stabilizes mRNA", "TNFs bind their physiological receptors"], "8742": ["TNFR2 non-canonical NF-kB pathway", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "8743": ["Caspase activation via Death Receptors in the presence of ligand", "Regulation by c-FLIP", "RIPK1-mediated regulated necrosis", "CASP8 activity is inhibited", "Dimerization of procaspase-8", "TRAIL signaling"], "8744": ["TNFs bind their physiological receptors"], "8745": ["LGI-ADAM interactions"], "8747": ["Interaction With The Zona Pellucida"], "8748": ["Interaction With The Zona Pellucida"], "875": ["Cysteine formation from homocysteine", "Metabolism of ingested SeMet, Sec, MeSec into H2Se"], "8751": ["Degradation of the extracellular matrix", "Invadopodia formation"], "8754": ["Collagen degradation"], "8760": ["Synthesis of PG"], "8764": ["Costimulation by the CD28 family", "Costimulation by the CD28 family", "TNFs bind their physiological receptors"], "8766": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Vasopressin regulates renal water homeostasis via Aquaporins", "Anchoring of the basal body to the plasma membrane", "VxPx cargo-targeting to cilium", "TBC/RABGAPs", "RAB geranylgeranylation"], "8767": ["NOD1/2 Signaling Pathway", "NOD1/2 Signaling Pathway", "Downstream TCR signaling", "p75NTR recruits signalling complexes", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "activated TAK1 mediates p38 MAPK activation", "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "Ovarian tumor domain proteases", "Interleukin-1 signaling"], "8771": ["TNFs bind their physiological receptors"], "8772": ["Caspase activation via Death Receptors in the presence of ligand", "TRIF-mediated programmed cell death", "Regulation by c-FLIP", "RIPK1-mediated regulated necrosis", "CASP8 activity is inhibited", "TNFR1-induced proapoptotic signaling", "Dimerization of procaspase-8", "FasL/ CD95L signaling", "TRAIL signaling", "TLR3-mediated TICAM1-dependent programmed cell death", "NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10"], "8773": ["ER-Phagosome pathway", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Clathrin derived vesicle budding", "Neutrophil degranulation"], "8774": ["COPII-mediated vesicle transport", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network"], "8775": ["COPII-mediated vesicle transport", "Golgi Associated Vesicle Biogenesis", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network"], "8776": ["Synthesis of PIPs at the plasma membrane"], "8778": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation"], "8780": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "8784": ["TNFs bind their physiological receptors", "RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)"], "8785": ["ECM proteoglycans"], "8786": ["G alpha (i) signalling events", "G alpha (i) signalling events", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "8787": ["Inactivation, recovery and regulation of the phototransduction cascade", "Inactivation, recovery and regulation of the phototransduction cascade", "G alpha (i) signalling events", "G alpha (i) signalling events", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "8788": ["Activated NOTCH1 Transmits Signal to the Nucleus"], "8789": ["Gluconeogenesis"], "8790": ["GDP-fucose biosynthesis"], "8792": ["TNFR2 non-canonical NF-kB pathway", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "8793": ["Cell surface interactions at the vascular wall", "TP53 Regulates Transcription of Death Receptors and Ligands", "TRAIL signaling"], "8794": ["TP53 Regulates Transcription of Death Receptors and Ligands"], "8795": ["Caspase activation via Death Receptors in the presence of ligand", "Cell surface interactions at the vascular wall", "Regulation by c-FLIP", "RIPK1-mediated regulated necrosis", "CASP8 activity is inhibited", "TP53 Regulates Transcription of Death Receptors and Ligands", "Dimerization of procaspase-8", "TRAIL signaling"], "8797": ["Caspase activation via Death Receptors in the presence of ligand", "Cell surface interactions at the vascular wall", "Regulation by c-FLIP", "RIPK1-mediated regulated necrosis", "CASP8 activity is inhibited", "TP53 Regulates Transcription of Death Receptors and Ligands", "Dimerization of procaspase-8", "TRAIL signaling"], "88": ["Platelet degranulation ", "Nephrin family interactions", "Striated Muscle Contraction", "Unblocking of NMDA receptors, glutamate binding and activation", "Unblocking of NMDA receptors, glutamate binding and activation", "Ras activation upon Ca2+ influx through NMDA receptor", "RAF/MAP kinase cascade", "Negative regulation of NMDA receptor-mediated neuronal transmission", "Long-term potentiation"], "8800": ["PPARA activates gene expression"], "8801": ["Citric acid cycle (TCA cycle)"], "8802": ["Citric acid cycle (TCA cycle)"], "8803": ["Citric acid cycle (TCA cycle)"], "8804": ["Neutrophil degranulation"], "8805": ["Signaling by cytosolic FGFR1 fusion mutants", "Signaling by FGFR1 in disease", "Signaling by BRAF and RAF fusions"], "8807": ["Interleukin-18 signaling"], "8808": ["Interleukin-38 signaling", "Interleukin-36 pathway"], "8809": ["Interleukin-37 signaling", "Interleukin-18 signaling"], "8811": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "8812": ["Formation of RNA Pol II elongation complex ", "Formation of HIV elongation complex in the absence of HIV Tat", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Transcription Elongation"], "8813": ["Synthesis of dolichyl-phosphate mannose", "Defective DPM1 causes DPM1-CDG (CDG-1e)"], "8815": ["Integration of provirus", "2-LTR circle formation", "Integration of viral DNA into host genomic DNA", "Autointegration results in viral DNA circles", "APOBEC3G mediated resistance to HIV-1 infection", "Vpr-mediated nuclear import of PICs", "Clearance of Nuclear Envelope Membranes from Chromatin", "Initiation of Nuclear Envelope Reformation"], "8816": ["Neddylation"], "8817": ["PI3K Cascade", "PIP3 activates AKT signaling", "Signaling by activated point mutants of FGFR3", "FGFR4 ligand binding and activation", "FGFR3b ligand binding and activation", "FGFR3c ligand binding and activation", "FGFR2c ligand binding and activation", "FGFR3 mutant receptor activation", "Activated point mutants of FGFR2", "Constitutive Signaling by Aberrant PI3K in Cancer", "Phospholipase C-mediated cascade; FGFR2", "Phospholipase C-mediated cascade; FGFR3", "Phospholipase C-mediated cascade; FGFR4", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "PI-3K cascade:FGFR3", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "PI-3K cascade:FGFR4", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "Signaling by FGFR2 in disease", "FGFRL1 modulation of FGFR1 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Signaling by FGFR3 point mutants in cancer"], "8818": ["Synthesis of dolichyl-phosphate mannose", "Synthesis of glycosylphosphatidylinositol (GPI)", "Defective DPM2 causes DPM2-CDG (CDG-1u)"], "8819": ["HDACs deacetylate histones", "NoRC negatively regulates rRNA expression"], "8821": ["Synthesis of PIPs at the plasma membrane", "Synthesis of PIPs at the early endosome membrane", "Synthesis of IP2, IP, and Ins in the cytosol"], "8822": ["PI3K Cascade", "PIP3 activates AKT signaling", "Signaling by activated point mutants of FGFR1", "Signaling by activated point mutants of FGFR3", "FGFR4 ligand binding and activation", "FGFR3b ligand binding and activation", "FGFR3c ligand binding and activation", "FGFR1c ligand binding and activation", "FGFR2c ligand binding and activation", "FGFR3 mutant receptor activation", "Activated point mutants of FGFR2", "Constitutive Signaling by Aberrant PI3K in Cancer", "Phospholipase C-mediated cascade: FGFR1", "Phospholipase C-mediated cascade; FGFR2", "Phospholipase C-mediated cascade; FGFR3", "Phospholipase C-mediated cascade; FGFR4", "Downstream signaling of activated FGFR1", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "PI-3K cascade:FGFR3", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "PI-3K cascade:FGFR4", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "Signaling by FGFR2 in disease", "Signaling by FGFR1 in disease", "FGFRL1 modulation of FGFR1 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Signaling by FGFR3 point mutants in cancer"], "8823": ["PI3K Cascade", "PIP3 activates AKT signaling", "Signaling by activated point mutants of FGFR3", "FGFR4 ligand binding and activation", "FGFR3c ligand binding and activation", "FGFR2c ligand binding and activation", "FGFR3 mutant receptor activation", "Activated point mutants of FGFR2", "Constitutive Signaling by Aberrant PI3K in Cancer", "Phospholipase C-mediated cascade; FGFR2", "Phospholipase C-mediated cascade; FGFR3", "Phospholipase C-mediated cascade; FGFR4", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "PI-3K cascade:FGFR3", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "PI-3K cascade:FGFR4", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "Signaling by FGFR2 in disease", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Signaling by FGFR3 point mutants in cancer"], "8824": ["Phase I - Functionalization of compounds"], "8825": ["Dopamine Neurotransmitter Release Cycle", "Neurexins and neuroligins"], "8826": ["Nephrin family interactions", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "RHO GTPases activate IQGAPs", "MAP2K and MAPK activation", "Neutrophil degranulation", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF"], "8828": ["Neurophilin interactions with VEGF and VEGFR", "NrCAM interactions"], "8829": ["Neurophilin interactions with VEGF and VEGFR", "Signaling by ROBO receptors", "Sema3A PAK dependent Axon repulsion", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "CRMPs in Sema3A signaling", "CRMPs in Sema3A signaling", "Signal transduction by L1", "CHL1 interactions"], "883": ["Amino acid synthesis and interconversion (transamination)", "Phenylalanine and tyrosine catabolism", "Tryptophan catabolism"], "8831": ["Regulation of RAS by GAPs", "Signaling by RAS mutants"], "8832": ["Cell surface interactions at the vascular wall"], "8833": ["Purine ribonucleoside monophosphate biosynthesis"], "8834": ["Cristae formation"], "8835": ["Interleukin-7 signaling", "Neddylation", "Growth hormone receptor signaling"], "8836": ["Neutrophil degranulation"], "8837": ["Regulation by c-FLIP", "RIPK1-mediated regulated necrosis", "CASP8 activity is inhibited", "Dimerization of procaspase-8", "TRAIL signaling"], "8841": ["NR1D1 (REV-ERBA) represses gene expression", "p75NTR negatively regulates cell cycle via SC1", "PPARA activates gene expression", "NOTCH1 Intracellular Domain Regulates Transcription", "Transcriptional activation of mitochondrial biogenesis", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "HDACs deacetylate histones", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation", "Association of TriC/CCT with target proteins during biosynthesis", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)", "Circadian Clock", "Circadian Clock", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "RUNX2 regulates osteoblast differentiation", "Regulation of PTEN gene transcription", "Loss of MECP2 binding ability to the NCoR/SMRT complex", "Regulation of MECP2 expression and activity"], "8843": ["Hydroxycarboxylic acid-binding receptors", "G alpha (i) signalling events"], "884327": ["ER-Phagosome pathway", "MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "Toll Like Receptor TLR6:TLR2 Cascade", "MyD88 deficiency (TLR2/4)", "IRAK4 deficiency (TLR2/4)"], "8844": ["RAF activation", "MAP2K and MAPK activation", "Negative regulation of MAPK pathway", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF"], "885": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "8850": ["Pre-NOTCH Transcription and Translation", "Pre-NOTCH Transcription and Translation", "YAP1- and WWTR1 (TAZ)-stimulated gene expression", "Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "NOTCH1 Intracellular Domain Regulates Transcription", "NOTCH1 Intracellular Domain Regulates Transcription", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "HATs acetylate histones", "Notch-HLH transcription pathway", "B-WICH complex positively regulates rRNA expression", "Physiological factors", "Metalloprotease DUBs", "RNA Polymerase I Transcription Initiation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX3 regulates NOTCH signaling", "RUNX3 regulates NOTCH signaling", "NOTCH3 Intracellular Domain Regulates Transcription", "NOTCH3 Intracellular Domain Regulates Transcription", "NOTCH4 Intracellular Domain Regulates Transcription", "Estrogen-dependent gene expression", "Regulation of FOXO transcriptional activity by acetylation"], "8851": ["CRMPs in Sema3A signaling", "CRMPs in Sema3A signaling", "Regulation of TP53 Activity through Phosphorylation", "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "Activated NTRK2 signals through CDK5"], "885357": ["Tolerance by Mtb to nitric oxide produced by macrophages", "Cell redox homeostasis"], "8854": ["RA biosynthesis pathway"], "885594": ["Tolerance of reactive oxygen produced by macrophages"], "8856": ["Nuclear Receptor transcription pathway", "SUMOylation of intracellular receptors"], "885638": ["Tolerance of reactive oxygen produced by macrophages"], "885717": ["Tolerance of reactive oxygen produced by macrophages", "Tolerance by Mtb to nitric oxide produced by macrophages", "Cell redox homeostasis"], "885767": ["Mtb iron assimilation by chelation"], "8858": ["Gamma-carboxylation of protein precursors", "Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "Removal of aminoterminal propeptides from gamma-carboxylated proteins"], "885959": ["Cell redox homeostasis"], "886": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "8861": ["RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of expression of SLITs and ROBOs"], "886174": ["Tolerance of reactive oxygen produced by macrophages"], "886176": ["Mtb iron assimilation by chelation"], "8862": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "886232": ["Cell redox homeostasis"], "886241": ["Tolerance by Mtb to nitric oxide produced by macrophages", "Cell redox homeostasis"], "886300": ["Cell redox homeostasis"], "886358": ["Tolerance of reactive oxygen produced by macrophages"], "8864": ["Circadian Clock"], "886402": ["Tolerance by Mtb to nitric oxide produced by macrophages"], "886418": ["Cell redox homeostasis"], "886624": ["Tolerance of reactive oxygen produced by macrophages"], "8867": ["Synthesis of PIPs at the plasma membrane", "Synthesis of IP2, IP, and Ins in the cytosol", "Synthesis of IP3 and IP4 in the cytosol", "Clathrin-mediated endocytosis"], "886834": ["Mtb iron assimilation by chelation", "Mtb iron assimilation by chelation"], "886853": ["Mtb iron assimilation by chelation", "Mtb iron assimilation by chelation"], "886865": ["Tolerance by Mtb to nitric oxide produced by macrophages"], "8869": ["Sialic acid metabolism"], "886980": ["Tolerance by Mtb to nitric oxide produced by macrophages"], "886981": ["Tolerance by Mtb to nitric oxide produced by macrophages"], "886985": ["Tolerance by Mtb to nitric oxide produced by macrophages"], "886997": ["Tolerance by Mtb to nitric oxide produced by macrophages"], "887": ["Peptide ligand-binding receptors", "G alpha (q) signalling events", "Gastrin-CREB signalling pathway via PKC and MAPK"], "8870": ["PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "8871": ["Synthesis of PIPs at the plasma membrane", "Clathrin-mediated endocytosis"], "887215": ["Tolerance by Mtb to nitric oxide produced by macrophages"], "887229": ["Tolerance of reactive oxygen produced by macrophages"], "8874": ["EGFR downregulation", "NRAGE signals death through JNK", "Rho GTPase cycle", "Ephrin signaling", "G alpha (12/13) signalling events", "Activation of RAC1 downstream of NMDARs"], "88745": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "8875": ["Post-translational modification: synthesis of GPI-anchored proteins", "Vitamin B5 (pantothenate) metabolism"], "8876": ["Post-translational modification: synthesis of GPI-anchored proteins", "Vitamin B5 (pantothenate) metabolism", "Neutrophil degranulation"], "8877": ["Sphingolipid de novo biosynthesis", "Association of TriC/CCT with target proteins during biosynthesis", "VEGFR2 mediated cell proliferation"], "8878": ["NRIF signals cell death from the nucleus", "p75NTR recruits signalling complexes", "NF-kB is activated and signals survival", "Pink/Parkin Mediated Mitophagy", "Interleukin-1 signaling"], "887871": ["Tolerance by Mtb to nitric oxide produced by macrophages"], "8879": ["Sphingolipid de novo biosynthesis"], "888042": ["Tolerance of reactive oxygen produced by macrophages"], "8881": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6", "Antigen processing: Ubiquitination & Proteasome degradation"], "888180": ["Mtb iron assimilation by chelation", "Mtb iron assimilation by chelation"], "888192": ["Tolerance of reactive oxygen produced by macrophages"], "8883": ["Neddylation"], "8884": ["Biotin transport and metabolism", "Vitamin B5 (pantothenate) metabolism", "Transport of vitamins, nucleosides, and related molecules"], "888559": ["Tolerance of reactive oxygen produced by macrophages"], "8887": ["Regulation of TNFR1 signaling", "Negative regulators of DDX58/IFIH1 signaling"], "888777": ["Cell redox homeostasis"], "888860": ["Tolerance of reactive oxygen produced by macrophages"], "8890": ["Recycling of eIF2:GDP"], "8891": ["Recycling of eIF2:GDP"], "8892": ["Recycling of eIF2:GDP"], "8893": ["Recycling of eIF2:GDP"], "8894": ["L13a-mediated translational silencing of Ceruloplasmin expression", "ABC-family proteins mediated transport", "Translation initiation complex formation", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Recycling of eIF2:GDP"], "8895": ["Glycerophospholipid biosynthesis", "Neutrophil degranulation"], "8896": ["mRNA Splicing - Major Pathway"], "8897": ["Macroautophagy", "Synthesis of PIPs at the plasma membrane"], "8898": ["Synthesis of PIPs at the ER membrane", "Synthesis of PIPs at the plasma membrane", "Synthesis of PIPs at the early endosome membrane", "Synthesis of PIPs at the early endosome membrane", "Synthesis of PIPs at the late endosome membrane"], "89": ["Nephrin family interactions", "Striated Muscle Contraction"], "890": ["Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1", "G0 and Early G1", "Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Regulation of APC/C activators between G1/S and early anaphase", "SCF(Skp2)-mediated degradation of p27/p21", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "Ub-specific processing proteases", "Processing of DNA double-strand break ends", "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "Regulation of TP53 Activity through Phosphorylation", "Regulation of TP53 Degradation", "G2 Phase", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Cyclin A/B1/B2 associated events during G2/M transition", "Cyclin A/B1/B2 associated events during G2/M transition", "p53-Dependent G1 DNA Damage Response", "Cyclin A:Cdk2-associated events at S phase entry"], "8900": ["G0 and Early G1", "Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Regulation of APC/C activators between G1/S and early anaphase", "SCF(Skp2)-mediated degradation of p27/p21", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "Activation of E2F1 target genes at G1/S", "Ub-specific processing proteases", "Processing of DNA double-strand break ends", "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "Regulation of TP53 Activity through Phosphorylation", "Regulation of TP53 Degradation", "G2 Phase", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Cyclin A/B1/B2 associated events during G2/M transition", "Cyclin A/B1/B2 associated events during G2/M transition", "p53-Dependent G1 DNA Damage Response", "Cyclin A:Cdk2-associated events at S phase entry"], "8904": ["Glycerophospholipid biosynthesis", "Neutrophil degranulation"], "8905": ["Nef mediated downregulation of MHC class I complex cell surface expression", "MHC class II antigen presentation", "Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis"], "8906": ["Lysosome Vesicle Biogenesis"], "8907": ["Nef mediated downregulation of MHC class I complex cell surface expression", "MHC class II antigen presentation", "Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis", "Neutrophil degranulation"], "8908": ["Glycogen synthesis", "Glycogen storage disease type 0 (liver GYS2)", "Glycogen storage disease type IV (GBE1)", "Glycogen breakdown (glycogenolysis)"], "891": ["E2F-enabled inhibition of pre-replication complex formation", "Polo-like kinase mediated events", "Golgi Cisternae Pericentriolar Stack Reorganization", "APC/C:Cdc20 mediated degradation of Cyclin B", "Regulation of APC/C activators between G1/S and early anaphase", "Phosphorylation of the APC/C", "Phosphorylation of Emi1", "Condensation of Prophase Chromosomes", "MASTL Facilitates Mitotic Progression", "Resolution of Sister Chromatid Cohesion", "Condensation of Prometaphase Chromosomes", "Regulation of PLK1 Activity at G2/M Transition", "Activation of NIMA Kinases NEK9, NEK6, NEK7", "Nuclear Pore Complex (NPC) Disassembly", "Depolymerisation of the Nuclear Lamina", "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "Mitotic Prophase", "Cyclin A/B1/B2 associated events during G2/M transition", "G2/M DNA replication checkpoint", "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "The role of GTSE1 in G2/M progression after G2 checkpoint", "Transcriptional regulation by RUNX2"], "8911": ["NCAM1 interactions"], "8912": ["NCAM1 interactions"], "89122": ["Antigen processing: Ubiquitination & Proteasome degradation"], "8913": ["NCAM1 interactions"], "8914": ["Processing of DNA double-strand break ends"], "8915": ["Activation of NF-kappaB in B cells", "Activation of NF-kappaB in B cells", "Downstream TCR signaling", "FCERI mediated NF-kB activation", "FCERI mediated NF-kB activation", "CLEC7A (Dectin-1) signaling", "E3 ubiquitin ligases ubiquitinate target proteins"], "8916": ["Antigen processing: Ubiquitination & Proteasome degradation"], "892": ["PPARA activates gene expression", "NOTCH1 Intracellular Domain Regulates Transcription", "Generic Transcription Pathway", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "8924": ["SUMOylation of DNA damage response and repair proteins", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "G2/M DNA damage checkpoint", "Antigen processing: Ubiquitination & Proteasome degradation"], "8925": ["Antigen processing: Ubiquitination & Proteasome degradation"], "8926": ["mRNA Splicing - Major Pathway"], "8928": ["Signaling by NODAL", "Signaling by Activin"], "8930": ["Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "Cleavage of the damaged pyrimidine ", "Displacement of DNA glycosylase by APEX1"], "8932": ["NoRC negatively regulates rRNA expression", "RNA Polymerase I Promoter Opening"], "8934": ["RAB geranylgeranylation"], "8935": ["Signal regulatory protein family interactions"], "8936": ["Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs"], "894": ["Cyclin D associated events in G1", "Regulation of RUNX1 Expression and Activity"], "8942": ["Tryptophan catabolism"], "8945": ["Activation of NF-kappaB in B cells", "Prolactin receptor signaling", "SCF-beta-TrCP mediated degradation of Emi1", "Vpu mediated degradation of CD4", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of PLK1 Activity at G2/M Transition", "FCERI mediated NF-kB activation", "Deactivation of the beta-catenin transactivating complex", "Circadian Clock", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "NIK-->noncanonical NF-kB signaling", "MAP3K8 (TPL2)-dependent MAPK1/3 activation", "Neddylation", "Interleukin-1 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "896": ["Transcriptional regulation of white adipocyte differentiation", "MAPK6/MAPK4 signaling", "Cyclin D associated events in G1", "Regulation of RUNX1 Expression and Activity"], "8968": ["Interleukin-7 signaling", "Interleukin-7 signaling", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "HDACs deacetylate histones", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "Chromatin modifying enzymes", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation", "Factors involved in megakaryocyte development and platelet production"], "8969": ["HDACs deacetylate histones", "HATs acetylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "UCH proteinases", "Ub-specific processing proteases", "Metalloprotease DUBs"], "8970": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "HATs acetylate histones", "HATs acetylate histones", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Ub-specific processing proteases", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "E3 ubiquitin ligases ubiquitinate target proteins", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "8972": ["Digestion of dietary carbohydrate", "Neutrophil degranulation"], "8973": ["Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "Highly calcium permeable nicotinic acetylcholine receptors"], "8974": ["Collagen biosynthesis and modifying enzymes"], "8975": ["Ub-specific processing proteases", "Regulation of PTEN stability and activity"], "8976": ["Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "NOSTRIN mediated eNOS trafficking", "Nephrin family interactions", "EPHB-mediated forward signaling", "EPHB-mediated forward signaling", "DCC mediated attractive signaling", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs", "Clathrin-mediated endocytosis"], "89777": ["Neutrophil degranulation"], "89780": ["TCF dependent signaling in response to WNT", "TCF dependent signaling in response to WNT", "WNT ligand biogenesis and trafficking", "WNT ligand biogenesis and trafficking", "Class B/2 (Secretin family receptors)", "Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Regulation of FZD by ubiquitination", "RNF mutants show enhanced WNT signaling and proliferation"], "89781": ["RAB GEFs exchange GTP for GDP on RABs"], "89790": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "898": ["G0 and Early G1", "SCF(Skp2)-mediated degradation of p27/p21", "DNA Damage/Telomere Stress Induced Senescence", "Association of TriC/CCT with target proteins during biosynthesis", "Activation of E2F1 target genes at G1/S", "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "CDK-mediated phosphorylation and removal of Cdc6", "Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes", "Cyclin E associated events during G1/S transition ", "p53-Dependent G1 DNA Damage Response", "PTK6 Regulates Cell Cycle"], "89822": ["TWIK-related alkaline pH activated K+ channel (TALK)", "Phase 4 - resting membrane potential"], "89832": ["Highly calcium permeable postsynaptic nicotinic acetylcholine receptors"], "89839": ["Rho GTPase cycle"], "89845": ["ABC-family proteins mediated transport"], "89846": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "8985": ["Collagen biosynthesis and modifying enzymes"], "89853": ["Budding and maturation of HIV virion", "Membrane binding and targetting of GAG proteins", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "89858": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "8986": ["Recycling pathway of L1"], "89866": ["COPII-mediated vesicle transport"], "89869": ["Synthesis of IP3 and IP4 in the cytosol"], "8987": ["Neutrophil degranulation"], "89872": ["Passive transport by Aquaporins"], "89874": ["Lysine catabolism"], "89884": ["Regulation of expression of SLITs and ROBOs"], "8989": ["TRP channels"], "89890": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "89891": ["Intraflagellar transport"], "899": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "89910": ["Antigen processing: Ubiquitination & Proteasome degradation"], "8992": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "8993": ["Neutrophil degranulation", "Antimicrobial peptides"], "8994": ["Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"], "89941": ["Rho GTPase cycle"], "8995": ["TNFs bind their physiological receptors"], "89953": ["MHC class II antigen presentation", "RHO GTPases activate KTN1", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "8997": ["NRAGE signals death through JNK", "Rho GTPase cycle", "EPHB-mediated forward signaling", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "MAPK6/MAPK4 signaling"], "89978": ["Synthesis of diphthamide-EEF2"], "9": ["Acetylation"], "900": ["Regulation of TP53 Degradation"], "90019": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "9002": ["Peptide ligand-binding receptors", "G alpha (q) signalling events", "Thrombin signalling through proteinase activated receptors (PARs)", "Thrombin signalling through proteinase activated receptors (PARs)"], "90025": ["Antigen processing: Ubiquitination & Proteasome degradation"], "90075": ["Generic Transcription Pathway"], "901": ["FOXO-mediated transcription of cell cycle genes"], "9013": ["SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase I Transcription Termination"], "90134": ["Voltage gated Potassium channels"], "90135": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "9014": ["SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase I Transcription Termination"], "9015": ["SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase I Transcription Termination"], "9016": ["The fatty acid cycling model", "The proton buffering model"], "90161": ["HS-GAG biosynthesis"], "90187": ["Molecules associated with elastic fibres", "Molecules associated with elastic fibres"], "90196": ["Retrograde transport at the Trans-Golgi-Network"], "902": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Tat-mediated elongation of the HIV-1 transcript", "NoRC negatively regulates rRNA expression", "Formation of Incision Complex in GG-NER", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "Cyclin E associated events during G1/S transition ", "Cyclin D associated events in G1", "Cyclin A/B1/B2 associated events during G2/M transition", "Cyclin A:Cdk2-associated events at S phase entry", "mRNA Capping", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase I Transcription Termination", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE", "RUNX1 regulates transcription of genes involved in differentiation of HSCs"], "9020": ["CD28 dependent PI3K/Akt signaling", "Dectin-1 mediated noncanonical NF-kB signaling", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "9021": ["Interleukin-6 signaling", "Signaling by Leptin", "Interleukin-4 and Interleukin-13 signaling", "Interferon gamma signaling", "Regulation of IFNG signaling", "PTK6 Activates STAT3", "RUNX1 regulates transcription of genes involved in differentiation of keratinocytes", "Neddylation", "Interferon alpha/beta signaling", "Regulation of IFNA signaling", "Growth hormone receptor signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "90226": ["Class B/2 (Secretin family receptors)"], "9023": ["Synthesis of bile acids and bile salts"], "90233": ["Generic Transcription Pathway"], "90249": ["Netrin-1 signaling", "Netrin mediated repulsion signals", "Caspase activation via Dependence Receptors in the absence of ligand"], "9025": ["Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "G2/M DNA damage checkpoint"], "9026": ["Golgi Associated Vesicle Biogenesis", "Clathrin-mediated endocytosis"], "90268": ["Regulation of TNFR1 signaling", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes"], "9027": ["Amyloid fiber formation"], "90293": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "9031": ["B-WICH complex positively regulates rRNA expression", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"], "90317": ["Generic Transcription Pathway"], "90333": ["Generic Transcription Pathway"], "90338": ["Generic Transcription Pathway"], "9034": ["Chemokine receptors bind chemokines"], "90353": ["tRNA modification in the nucleus and cytosol"], "9037": ["Other semaphorin interactions", "Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "9038": ["Amine ligand-binding receptors", "G alpha (s) signalling events"], "9039": ["Dectin-1 mediated noncanonical NF-kB signaling", "NIK-->noncanonical NF-kB signaling", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "90390": ["PPARA activates gene expression", "Generic Transcription Pathway", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "904": ["Formation of RNA Pol II elongation complex ", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "Interactions of Tat with host cellular proteins", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Transcription Elongation", "Estrogen-dependent gene expression"], "9040": ["TGF-beta receptor signaling activates SMADs", "Dectin-1 mediated noncanonical NF-kB signaling", "NIK-->noncanonical NF-kB signaling", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "904054": ["ER-Phagosome pathway", "MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "Toll Like Receptor TLR1:TLR2 Cascade", "MyD88 deficiency (TLR2/4)", "IRAK4 deficiency (TLR2/4)"], "90410": ["Intraflagellar transport", "Intraflagellar transport"], "90411": ["COPII-mediated vesicle transport", "Cargo concentration in the ER", "Transport to the Golgi and subsequent modification"], "90423": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "90427": ["BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "Activation of BMF and translocation to mitochondria"], "9043": ["CDO in myogenesis", "CDO in myogenesis"], "9045": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "90459": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "9046": ["Tie2 Signaling", "RET signaling"], "9047": ["VEGFA-VEGFR2 Pathway"], "9048": ["NCAM1 interactions", "RAF/MAP kinase cascade", "RET signaling"], "90480": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "9049": ["Aryl hydrocarbon receptor signalling", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "905": ["Formation of RNA Pol II elongation complex ", "Formation of HIV elongation complex in the absence of HIV Tat", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Transcription Elongation"], "9051": ["The NLRP3 inflammasome"], "9054": ["Mitochondrial iron-sulfur cluster biogenesis", "Molybdenum cofactor biosynthesis"], "9055": ["RHO GTPases activate CIT"], "90550": ["Mitochondrial calcium ion transport", "Processing of SMDT1"], "9056": ["Basigin interactions", "Amino acid transport across the plasma membrane", "Defective SLC7A7 causes lysinuric protein intolerance (LPI)"], "9057": ["Basigin interactions", "Amino acid transport across the plasma membrane"], "90576": ["Generic Transcription Pathway"], "9058": ["Sodium-coupled sulphate, di- and tri-carboxylate transporters"], "90589": ["Generic Transcription Pathway"], "90592": ["Generic Transcription Pathway"], "90594": ["Generic Transcription Pathway"], "9060": ["Transport and synthesis of PAPS", "Metabolism of ingested H2SeO4 and H2SeO3 into H2Se", "Defective PAPSS2 causes SEMD-PA"], "9061": ["Transport and synthesis of PAPS", "Metabolism of ingested H2SeO4 and H2SeO3 into H2Se", "Signaling by BRAF and RAF fusions"], "90627": ["Rho GTPase cycle"], "9063": ["SUMOylation of DNA damage response and repair proteins", "SUMOylation of transcription factors", "SUMOylation of ubiquitinylation proteins", "SUMOylation of transcription cofactors", "SUMOylation of intracellular receptors", "SUMOylation of intracellular receptors", "SUMOylation of chromatin organization proteins", "Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "90639": ["Mitochondrial protein import"], "90649": ["Generic Transcription Pathway"], "9066": ["Neurexins and neuroligins"], "90678": ["Antigen processing: Ubiquitination & Proteasome degradation"], "9069": ["Tight junction interactions"], "9070": ["Formation of the beta-catenin:TCF transactivating complex", "PKMTs methylate histone lysines", "Deactivation of the beta-catenin transactivating complex", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"], "90701": ["SRP-dependent cotranslational protein targeting to membrane", "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)", "Synthesis, secretion, and deacylation of Ghrelin"], "9071": ["Tight junction interactions"], "9073": ["Tight junction interactions"], "9074": ["Tight junction interactions"], "9075": ["Tight junction interactions"], "9076": ["Tight junction interactions"], "90780": ["Formation of the beta-catenin:TCF transactivating complex", "Deactivation of the beta-catenin transactivating complex"], "908": ["Prefoldin mediated transfer of substrate to CCT/TriC", "Formation of tubulin folding intermediates by CCT/TriC", "Folding of actin by CCT/TriC", "Association of TriC/CCT with target proteins during biosynthesis", "Association of TriC/CCT with target proteins during biosynthesis", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "9080": ["Tight junction interactions"], "90809": ["PI5P Regulates TP53 Acetylation", "Synthesis of PIPs in the nucleus"], "90827": ["Generic Transcription Pathway"], "90864": ["Neddylation"], "90865": ["PIP3 activates AKT signaling", "Ub-specific processing proteases", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Interleukin-33 signaling"], "90874": ["Generic Transcription Pathway"], "9088": ["Polo-like kinase mediated events", "Cyclin A/B1/B2 associated events during G2/M transition", "Cyclin A/B1/B2 associated events during G2/M transition", "G2/M DNA replication checkpoint"], "909": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "9091": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "9092": ["mRNA Splicing - Major Pathway"], "90933": ["Antigen processing: Ubiquitination & Proteasome degradation"], "90952": ["Cell surface interactions at the vascular wall"], "9097": ["Ub-specific processing proteases"], "9099": ["TNFR1-induced proapoptotic signaling", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "Ub-specific processing proteases", "Regulation of TP53 Degradation"], "90990": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "90993": ["CREB3 factors activate genes"], "91": ["Signaling by NODAL", "Regulation of signaling by NODAL", "Signaling by Activin"], "910": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "9100": ["Termination of translesion DNA synthesis", "Ub-specific processing proteases"], "9101": ["Downregulation of ERBB2:ERBB3 signaling", "Regulation of FZD by ubiquitination", "Ub-specific processing proteases", "Negative regulation of MET activity"], "91010": ["RHO GTPases Activate Formins"], "91012": ["Sphingolipid de novo biosynthesis"], "9107": ["Synthesis of PIPs at the plasma membrane"], "9108": ["Synthesis of PIPs at the late endosome membrane", "Synthesis of PIPs at the late endosome membrane", "Synthesis of IP2, IP, and Ins in the cytosol"], "911": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "9110": ["Synthesis of PIPs at the early endosome membrane", "Synthesis of PIPs at the late endosome membrane", "Downregulation of TGF-beta receptor signaling"], "9112": ["HDACs deacetylate histones", "SUMOylation of transcription factors", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "RNA Polymerase I Transcription Initiation", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription"], "91120": ["Generic Transcription Pathway"], "9113": ["Signaling by Hippo"], "9114": ["ROS, RNS production in phagocytes", "XBP1(S) activates chaperone genes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "91147": ["Anchoring of the basal body to the plasma membrane"], "9117": ["COPII-mediated vesicle transport"], "9119": ["Keratinization", "Formation of the cornified envelope"], "912": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "9123": ["Basigin interactions", "Proton-coupled monocarboxylate transport", "Pyruvate metabolism"], "9125": ["Deadenylation of mRNA", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "9126": ["Meiotic synapsis", "Separation of Sister Chromatids", "Establishment of Sister Chromatid Cohesion", "Cohesin Loading onto Chromatin", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA damage response and repair proteins", "Estrogen-dependent gene expression"], "9127": ["Elevation of cytosolic Ca2+ levels", "Platelet homeostasis"], "9128": ["mRNA Splicing - Major Pathway"], "91289": ["Assembly of active LPL and LIPC lipase complexes"], "9129": ["mRNA Splicing - Major Pathway"], "91319": ["ABC-family proteins mediated transport", "Defective CFTR causes cystic fibrosis"], "9132": ["Voltage gated Potassium channels"], "9133": ["Polo-like kinase mediated events", "Golgi Cisternae Pericentriolar Stack Reorganization", "Resolution of Sister Chromatid Cohesion", "Condensation of Prometaphase Chromosomes", "Regulation of PLK1 Activity at G2/M Transition", "Activation of NIMA Kinases NEK9, NEK6, NEK7", "Nuclear Pore Complex (NPC) Disassembly", "Cyclin A/B1/B2 associated events during G2/M transition", "G2/M DNA replication checkpoint", "The role of GTSE1 in G2/M progression after G2 checkpoint"], "9134": ["G0 and Early G1", "SCF(Skp2)-mediated degradation of p27/p21", "DNA Damage/Telomere Stress Induced Senescence", "Association of TriC/CCT with target proteins during biosynthesis", "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "CDK-mediated phosphorylation and removal of Cdc6", "Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes", "Cyclin E associated events during G1/S transition ", "p53-Dependent G1 DNA Damage Response"], "9135": ["TBC/RABGAPs"], "9136": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "9138": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "914": ["Cell surface interactions at the vascular wall"], "9140": ["Macroautophagy", "Macroautophagy", "Pink/Parkin Mediated Mitophagy", "Receptor Mediated Mitophagy", "Negative regulators of DDX58/IFIH1 signaling"], "91442": ["Fanconi Anemia Pathway"], "91445": ["ABC-family proteins mediated transport", "Defective CFTR causes cystic fibrosis", "ER Quality Control Compartment (ERQC)"], "9145": ["Neutrophil degranulation"], "91452": ["Peroxisomal lipid metabolism"], "9146": ["EGFR downregulation", "Lysosome Vesicle Biogenesis", "Ub-specific processing proteases", "Negative regulation of MET activity", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "InlB-mediated entry of Listeria monocytogenes into host cell", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "9148": ["Activated NOTCH1 Transmits Signal to the Nucleus", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "NOTCH2 Activation and Transmission of Signal to the Nucleus", "NOTCH3 Activation and Transmission of Signal to the Nucleus"], "915": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Downstream TCR signaling", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "PD-1 signaling", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "9150": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Abortive elongation of HIV-1 transcript in the absence of Tat", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "RNA Polymerase II Transcription Elongation"], "9152": ["Na+/Cl- dependent neurotransmitter transporters", "Defective SLC6A5 causes hyperekplexia 3 (HKPX3)"], "91522": ["Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Integrin cell surface interactions", "Collagen chain trimerization"], "9153": ["Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"], "9154": ["Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"], "91543": ["Interferon alpha/beta signaling"], "9156": ["Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Regulation of TP53 Activity through Phosphorylation", "G2/M DNA damage checkpoint"], "91582": ["Regulation of HSF1-mediated heat shock response"], "91584": ["Sema3A PAK dependent Axon repulsion", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "CRMPs in Sema3A signaling", "CRMPs in Sema3A signaling", "Other semaphorin interactions", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes"], "916": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Downstream TCR signaling", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "PD-1 signaling"], "91603": ["Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER"], "91614": ["Rho GTPase cycle"], "9162": ["Effects of PIP2 hydrolysis"], "91646": ["PIWI-interacting RNA (piRNA) biogenesis"], "91653": ["CDO in myogenesis", "CDO in myogenesis", "Ligand-receptor interactions", "Activation of SMO"], "9166": ["Estrogen-dependent gene expression"], "9167": ["TP53 Regulates Metabolic Genes", "Respiratory electron transport"], "91683": ["Neurexins and neuroligins"], "91687": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Deposition of new CENPA-containing nucleosomes at the centromere", "Mitotic Prometaphase"], "91689": ["Mitochondrial calcium ion transport", "Processing of SMDT1"], "91694": ["Antigen processing: Ubiquitination & Proteasome degradation"], "917": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Downstream TCR signaling", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "PD-1 signaling", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "9170": ["G alpha (q) signalling events", "G alpha (i) signalling events", "Lysosphingolipid and LPA receptors"], "91703": ["Aflatoxin activation and detoxification"], "9173": ["PIP3 activates AKT signaling", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Interleukin-33 signaling"], "91734": ["Cholesterol biosynthesis"], "91749": ["Cellular hexose transport"], "91750": ["Transcription of E2F targets under negative control by DREAM complex", "Transcription of E2F targets under negative control by DREAM complex", "Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1", "G0 and Early G1", "Polo-like kinase mediated events", "Activation of E2F1 target genes at G1/S", "Cyclin E associated events during G1/S transition ", "Cyclin A:Cdk2-associated events at S phase entry"], "91754": ["Activation of NIMA Kinases NEK9, NEK6, NEK7", "Nuclear Pore Complex (NPC) Disassembly"], "91768": ["Cyclin E associated events during G1/S transition ", "Cyclin A:Cdk2-associated events at S phase entry", "Factors involved in megakaryocyte development and platelet production"], "9177": ["Neurotransmitter receptors and postsynaptic signal transmission"], "91782": ["Budding and maturation of HIV virion", "Macroautophagy", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "9179": ["Lysosome Vesicle Biogenesis"], "9180": ["IL-6-type cytokine receptor ligand interactions"], "91801": ["tRNA modification in the nucleus and cytosol"], "9181": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "9183": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "COPI-dependent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase"], "91833": ["Ub-specific processing proteases"], "9184": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "APC/C:Cdc20 mediated degradation of mitotic proteins", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "9185": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "91851": ["Signaling by BMP", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "91869": ["Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "Defective RFT1 causes RFT1-CDG (CDG-1n)"], "9187": ["Activation of the phototransduction cascade", "Sodium/Calcium exchangers", "Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D)"], "91875": ["Regulation of TP53 Activity through Methylation"], "9188": ["B-WICH complex positively regulates rRNA expression", "Major pathway of rRNA processing in the nucleolus and cytosol"], "9189": ["SUMOylation of chromatin organization proteins"], "919": ["Nef and signal transduction", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Downstream TCR signaling", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "PD-1 signaling"], "9194": ["Proton-coupled monocarboxylate transport"], "91942": ["Complex I biogenesis"], "91949": ["COPI-mediated anterograde transport", "Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network"], "9196": ["Voltage gated Potassium channels"], "9197": ["Transport of vitamins, nucleosides, and related molecules", "Defective SLC33A1 causes spastic paraplegia 42 (SPG42)"], "91975": ["Generic Transcription Pathway"], "91978": ["Carboxyterminal post-translational modifications of tubulin"], "92": ["Signaling by NODAL", "Regulation of signaling by NODAL", "Signaling by Activin", "Signaling by Activin", "Signaling by BMP"], "920": ["Alpha-defensins", "Nef Mediated CD4 Down-regulation", "Binding and entry of HIV virion", "Vpu mediated degradation of CD4", "Downstream TCR signaling", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "PD-1 signaling", "Other interleukin signaling", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "9200": ["Synthesis of very long-chain fatty acyl-CoAs"], "9208": ["Signaling by cytosolic FGFR1 fusion mutants", "LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "Signaling by FGFR1 in disease"], "9210": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "92104": ["Intraflagellar transport", "Intraflagellar transport"], "92105": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes"], "9211": ["LGI-ADAM interactions"], "9212": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA replication proteins", "RHO GTPases Activate Formins", "Regulation of TP53 Activity through Phosphorylation", "Mitotic Prometaphase", "Regulation of MECP2 expression and activity"], "92126": ["Dermatan sulfate biosynthesis"], "9215": ["Defective LARGE causes MDDGA6 and MDDGB6", "O-linked glycosylation"], "9217": ["Sphingolipid de novo biosynthesis"], "9218": ["Sphingolipid de novo biosynthesis", "Neutrophil degranulation"], "9219": ["HDACs deacetylate histones", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "Regulation of TP53 Activity through Acetylation", "RNA Polymerase I Transcription Initiation", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription"], "92259": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "9227": ["Retinoid cycle disease events", "The canonical retinoid cycle in rods (twilight vision)", "Retinoid metabolism and transport"], "92283": ["Generic Transcription Pathway"], "92285": ["Generic Transcription Pathway"], "9229": ["Neurexins and neuroligins", "Neurexins and neuroligins"], "92291": ["Degradation of the extracellular matrix"], "92292": ["Conjugation of salicylate with glycine", "Conjugation of benzoate with glycine"], "9230": ["TBC/RABGAPs", "RAB geranylgeranylation"], "92305": ["E3 ubiquitin ligases ubiquitinate target proteins"], "9232": ["APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Separation of Sister Chromatids"], "92335": ["Energy dependent regulation of mTOR by LKB1-AMPK"], "9235": ["Other interleukin signaling"], "92359": ["Tight junction interactions"], "92369": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "92399": ["Mitochondrial translation termination"], "9241": ["Signaling by BMP"], "92421": ["Budding and maturation of HIV virion", "Macroautophagy", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "9244": ["IL-6-type cytokine receptor ligand interactions", "Interleukin-27 signaling"], "9245": ["O-linked glycosylation of mucins"], "9246": ["ISG15 antiviral mechanism", "DDX58/IFIH1-mediated induction of interferon-alpha/beta", "Termination of translesion DNA synthesis", "Negative regulators of DDX58/IFIH1 signaling", "Negative regulators of DDX58/IFIH1 signaling", "Amyloid fiber formation", "Antigen processing: Ubiquitination & Proteasome degradation"], "92482": ["BBSome-mediated cargo-targeting to cilium"], "92483": ["Pyruvate metabolism"], "9249": ["The retinoid cycle in cones (daylight vision)", "RA biosynthesis pathway"], "925": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "9252": ["ERK/MAPK targets", "CREB phosphorylation", "NCAM signaling for neurite out-growth", "Recycling pathway of L1", "CD209 (DC-SIGN) signaling"], "9254": ["Presynaptic depolarization and calcium channel opening", "Adrenaline,noradrenaline inhibits insulin secretion", "Regulation of insulin secretion", "Regulation of insulin secretion", "Phase 0 - rapid depolarisation", "Phase 2 - plateau phase"], "9255": ["SeMet incorporation into proteins", "Cytosolic tRNA aminoacylation"], "92552": ["Josephin domain DUBs"], "9256": ["Serotonin Neurotransmitter Release Cycle", "Norepinephrine Neurotransmitter Release Cycle", "Pregnenolone biosynthesis", "Glutamate Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle", "Acetylcholine Neurotransmitter Release Cycle"], "92579": ["Severe congenital neutropenia type 4 (G6PC3)", "Gluconeogenesis"], "92591": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "92595": ["Generic Transcription Pathway"], "92597": ["Signaling by Hippo"], "926": ["Nef Mediated CD8 Down-regulation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "9260": ["RET signaling"], "92609": ["Mitochondrial protein import"], "9261": ["p38MAPK events", "CREB phosphorylation", "Synthesis of Leukotrienes (LT) and Eoxins (EX)", "Oxidative Stress Induced Senescence", "Regulation of HSF1-mediated heat shock response", "VEGFA-VEGFR2 Pathway", "activated TAK1 mediates p38 MAPK activation", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA"], "9265": ["Intra-Golgi traffic"], "9266": ["Intra-Golgi traffic"], "9267": ["Intra-Golgi traffic"], "9271": ["PIWI-interacting RNA (piRNA) biogenesis"], "92715": ["Synthesis of diphthamide-EEF2"], "92737": ["Activated NOTCH1 Transmits Signal to the Nucleus"], "92745": ["Amino acid transport across the plasma membrane"], "92747": ["Antimicrobial peptides"], "9276": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "9277": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "928": ["Platelet degranulation ", "Sperm:Oocyte Membrane Binding", "Uptake and function of diphtheria toxin"], "92815": ["HDACs deacetylate histones", "HATs acetylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "UCH proteinases", "Ub-specific processing proteases", "Metalloprotease DUBs"], "9282": ["PPARA activates gene expression", "Generic Transcription Pathway", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "9283": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "92840": ["Olfactory Signaling Pathway"], "92856": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "9287": ["Amine ligand-binding receptors", "G alpha (s) signalling events"], "929": ["ER-Phagosome pathway", "Caspase activation via Death Receptors in the presence of ligand", "Toll Like Receptor 4 (TLR4) Cascade", "Transfer of LPS from LBP carrier to CD14", "MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "MyD88-independent TLR4 cascade ", "Toll Like Receptor TLR1:TLR2 Cascade", "Toll Like Receptor TLR6:TLR2 Cascade", "TRIF-mediated programmed cell death", "MyD88 deficiency (TLR2/4)", "IRAK4 deficiency (TLR2/4)", "Regulation of TLR by endogenous ligand", "Neutrophil degranulation", "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon", "IKK complex recruitment mediated by RIP1", "TRAF6-mediated induction of TAK1 complex within TLR4 complex", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"], "9290": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (i) signalling events"], "92912": ["Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Antigen processing: Ubiquitination & Proteasome degradation"], "92935": ["Mitochondrial tRNA aminoacylation"], "9294": ["G alpha (i) signalling events", "Lysosphingolipid and LPA receptors"], "92949": ["Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "9295": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing"], "9296": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "93": ["Signaling by NODAL", "Regulation of signaling by NODAL", "Signaling by Activin", "Signaling by Activin", "Signaling by BMP"], "930": ["PIP3 activates AKT signaling", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Constitutive Signaling by Aberrant PI3K in Cancer", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "93010": ["Keratan sulfate biosynthesis", "O-linked glycosylation of mucins"], "93034": ["Purine catabolism"], "93058": ["Respiratory electron transport"], "9306": ["Regulation of KIT signaling", "Neddylation"], "9310": ["Generic Transcription Pathway"], "93100": ["Nicotinamide salvaging", "Neutrophil degranulation"], "93107": ["Voltage gated Potassium channels"], "9311": ["Stimuli-sensing channels"], "9312": ["Voltage gated Potassium channels"], "9313": ["Collagen degradation", "Degradation of the extracellular matrix", "Degradation of the extracellular matrix", "Assembly of collagen fibrils and other multimeric structures"], "93134": ["Generic Transcription Pathway"], "9314": ["Transcriptional regulation of white adipocyte differentiation", "Synthesis, secretion, and deacylation of Ghrelin", "Transcriptional regulation of pluripotent stem cells", "FOXO-mediated transcription of cell cycle genes"], "9318": ["DNA Damage Recognition in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Cargo recognition for clathrin-mediated endocytosis", "Neddylation"], "93183": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "932": ["Neutrophil degranulation"], "9320": ["Antigen processing: Ubiquitination & Proteasome degradation"], "9321": ["Intraflagellar transport", "Intra-Golgi traffic"], "9322": ["Rho GTPase cycle", "Clathrin-mediated endocytosis"], "9328": ["RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter"], "9329": ["RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter"], "933": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "CD22 mediated BCR regulation", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "9330": ["RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter"], "9331": ["Keratan sulfate biosynthesis", "O-linked glycosylation of mucins", "N-Glycan antennae elongation"], "9332": ["Scavenging of heme from plasma"], "93323": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "9333": ["Formation of the cornified envelope"], "9334": ["Keratan sulfate biosynthesis", "O-linked glycosylation of mucins", "N-Glycan antennae elongation"], "93343": ["Budding and maturation of HIV virion", "Membrane binding and targetting of GAG proteins", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "9337": ["Deadenylation of mRNA", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "93380": ["Miscellaneous transport and binding events"], "9340": ["G alpha (s) signalling events", "Glucagon-type ligand receptors"], "93408": ["Smooth Muscle Contraction"], "9341": ["ER-Phagosome pathway", "Retrograde transport at the Trans-Golgi-Network", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "9342": ["Neutrophil degranulation", "Intra-Golgi traffic"], "93426": ["Meiotic synapsis"], "9343": ["mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "93474": ["Generic Transcription Pathway"], "9348": ["HS-GAG biosynthesis"], "9349": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "93492": ["Synthesis of PIPs at the Golgi membrane"], "9350": ["Signaling by NODAL", "Regulation of signaling by NODAL", "Signaling by BMP"], "9353": ["Netrin-1 signaling", "Signaling by ROBO receptors", "Signaling by ROBO receptors", "Activation of RAC1", "Regulation of commissural axon pathfinding by SLIT and ROBO", "Inactivation of CDC42 and RAC1", "Role of ABL in ROBO-SLIT signaling", "Role of ABL in ROBO-SLIT signaling", "SLIT2:ROBO1 increases RHOA activity", "Regulation of expression of SLITs and ROBOs", "Regulation of expression of SLITs and ROBOs"], "9354": ["Antigen processing: Ubiquitination & Proteasome degradation"], "9355": ["Regulation of expression of SLITs and ROBOs"], "9356": ["Organic anion transport"], "9358": ["RUNX2 regulates genes involved in cell migration"], "93587": ["tRNA modification in the nucleus and cytosol"], "93589": ["Phase 0 - rapid depolarisation", "Phase 2 - plateau phase"], "93611": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "9362": ["Glycerophospholipid biosynthesis"], "93624": ["HATs acetylate histones", "Ub-specific processing proteases"], "9363": ["TBC/RABGAPs", "RAB geranylgeranylation"], "9365": ["PI3K Cascade", "PIP3 activates AKT signaling", "FGFR1c and Klotho ligand binding and activation", "Constitutive Signaling by Aberrant PI3K in Cancer", "Phospholipase C-mediated cascade: FGFR1", "Downstream signaling of activated FGFR1", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "Negative regulation of FGFR1 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "93659": ["Glycoprotein hormones", "TFAP2 (AP-2) family regulates transcription of growth factors and their receptors"], "93661": ["MHC class II antigen presentation", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic"], "93663": ["Rho GTPase cycle"], "9367": ["Retrograde transport at the Trans-Golgi-Network", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "9369": ["Neurexins and neuroligins", "Neurexins and neuroligins"], "9370": ["AMPK inhibits chREBP transcriptional activation activity", "AMPK inhibits chREBP transcriptional activation activity", "Transcriptional regulation of white adipocyte differentiation"], "9371": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "MHC class II antigen presentation", "Intraflagellar transport", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins", "Kinesins"], "9372": ["Downregulation of TGF-beta receptor signaling", "TGF-beta receptor signaling activates SMADs", "SMAD2/3 Phosphorylation Motif Mutants in Cancer", "SMAD2/3 MH2 Domain Mutants in Cancer", "TGFBR1 KD Mutants in Cancer"], "9374": ["Fatty acyl-CoA biosynthesis"], "9376": ["Organic anion transport"], "9377": ["TP53 Regulates Metabolic Genes", "Respiratory electron transport"], "9378": ["Non-integrin membrane-ECM interactions", "Neurexins and neuroligins", "Neurexins and neuroligins"], "9379": ["Neurexins and neuroligins", "Neurexins and neuroligins"], "9380": ["Glyoxylate metabolism and glycine degradation"], "9382": ["COPI-mediated anterograde transport", "Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network"], "9388": ["HDL remodeling"], "939": ["TNFs bind their physiological receptors"], "9390": ["Nicotinamide salvaging"], "9391": ["Cytosolic iron-sulfur cluster assembly"], "9394": ["HS-GAG biosynthesis"], "9397": ["Membrane binding and targetting of GAG proteins", "Inactivation, recovery and regulation of the phototransduction cascade"], "93973": ["UCH proteinases", "DNA Damage Recognition in GG-NER"], "93978": ["Dectin-2 family", "Dectin-2 family"], "9398": ["Generation of second messenger molecules"], "94": ["Signaling by BMP"], "940": ["PIP3 activates AKT signaling", "Nef mediated downregulation of CD28 cell surface expression", "Constitutive Signaling by Aberrant PI3K in Cancer", "CD28 co-stimulation", "CD28 dependent PI3K/Akt signaling", "CD28 dependent Vav1 pathway", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "94005": ["Attachment of GPI anchor to uPAR"], "94015": ["Stimuli-sensing channels"], "9402": ["Signaling by SCF-KIT", "Generation of second messenger molecules", "DAP12 signaling", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "CD28 co-stimulation"], "94025": ["Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)", "Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)", "Defective GALNT12 causes colorectal cancer 1 (CRCS1)", "Dectin-2 family", "O-linked glycosylation of mucins", "Termination of O-glycan biosynthesis"], "94030": ["Receptor-type tyrosine-protein phosphatases"], "94033": ["Iron uptake and transport"], "94039": ["Generic Transcription Pathway"], "941": ["PIP3 activates AKT signaling", "Constitutive Signaling by Aberrant PI3K in Cancer", "CD28 co-stimulation", "CD28 dependent PI3K/Akt signaling", "CD28 dependent Vav1 pathway", "CTLA4 inhibitory signaling", "Interleukin-10 signaling", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "9410": ["mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "94101": ["Sphingolipid de novo biosynthesis"], "94103": ["Sphingolipid de novo biosynthesis", "Neutrophil degranulation"], "9411": ["Rho GTPase cycle"], "94115": ["Glycoprotein hormones", "TFAP2 (AP-2) family regulates transcription of growth factors and their receptors"], "9412": ["PPARA activates gene expression", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "94121": ["Platelet degranulation "], "94134": ["Rho GTPase cycle"], "9414": ["Signaling by Hippo", "Apoptotic cleavage of cell adhesion proteins"], "9415": ["Linoleic acid (LA) metabolism", "alpha-linolenic acid (ALA) metabolism", "alpha-linolenic acid (ALA) metabolism"], "9416": ["mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "942": ["PIP3 activates AKT signaling", "Constitutive Signaling by Aberrant PI3K in Cancer", "CD28 co-stimulation", "CD28 dependent PI3K/Akt signaling", "CD28 dependent Vav1 pathway", "CTLA4 inhibitory signaling", "Interleukin-10 signaling", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "9420": ["Synthesis of bile acids and bile salts", "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "Endogenous sterols", "Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3)"], "9422": ["Generic Transcription Pathway"], "9423": ["Netrin-1 signaling", "Netrin-1 signaling", "DSCAM interactions", "DCC mediated attractive signaling", "DCC mediated attractive signaling", "Netrin mediated repulsion signals", "Role of second messengers in netrin-1 signaling", "Regulation of commissural axon pathfinding by SLIT and ROBO"], "94233": ["G alpha (q) signalling events", "Opsins"], "94235": ["Activation of G protein gated Potassium channels", "Glucagon signaling in metabolic regulation", "G-protein activation", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42", "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "94239": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Deposition of new CENPA-containing nucleosomes at the centromere", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination"], "9424": ["Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)", "Phase 4 - resting membrane potential"], "94241": ["TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "Regulation of TP53 Activity through Phosphorylation"], "94274": ["RHO GTPases activate PKNs"], "9429": ["Abacavir transmembrane transport", "Iron uptake and transport"], "943": ["TNFs bind their physiological receptors"], "9435": ["Keratan sulfate biosynthesis"], "9436": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "DAP12 interactions"], "9437": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "9439": ["PPARA activates gene expression", "Generic Transcription Pathway", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "944": ["TNFs bind their physiological receptors"], "9440": ["PPARA activates gene expression", "Generic Transcription Pathway", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "9441": ["PPARA activates gene expression", "Generic Transcription Pathway", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "9442": ["PPARA activates gene expression", "Generic Transcription Pathway", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "9443": ["PPARA activates gene expression", "Generic Transcription Pathway", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "9444": ["Signaling by BRAF and RAF fusions"], "9445": ["Amyloid fiber formation"], "9446": ["Methylation", "Glutathione conjugation", "Vitamin C (ascorbate) metabolism", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "9447": ["The AIM2 inflammasome", "The AIM2 inflammasome"], "9448": ["Oxidative Stress Induced Senescence"], "945": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation"], "9450": ["Toll Like Receptor 4 (TLR4) Cascade"], "9451": ["PERK regulates gene expression"], "9453": ["Cholesterol biosynthesis", "Activation of gene expression by SREBF (SREBP)"], "9454": ["Neurexins and neuroligins", "Neurexins and neuroligins"], "9455": ["Neurexins and neuroligins", "Neurexins and neuroligins"], "9456": ["Neurexins and neuroligins", "Neurexins and neuroligins"], "9459": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events", "Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "G beta:gamma signalling through CDC42"], "946": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "9462": ["Regulation of RAS by GAPs", "Signaling by RAS mutants"], "9463": ["Cell surface interactions at the vascular wall", "Trafficking of GluR2-containing AMPA receptors"], "9464": ["Transcriptional regulation by RUNX2"], "9466": ["Interleukin-35 Signalling", "Interleukin-27 signaling", "Interleukin-27 signaling"], "9468": ["Synthesis of PC"], "9469": ["Chondroitin sulfate biosynthesis", "Defective CHST3 causes SEDCJD"], "947": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "9470": ["ISG15 antiviral mechanism"], "9474": ["Macroautophagy", "Macroautophagy", "Pink/Parkin Mediated Mitophagy", "Receptor Mediated Mitophagy", "Negative regulators of DDX58/IFIH1 signaling"], "9475": ["EPHB-mediated forward signaling", "EPHB-mediated forward signaling", "EPHA-mediated growth cone collapse", "G alpha (12/13) signalling events", "Sema4D induced cell migration and growth-cone collapse", "Sema4D induced cell migration and growth-cone collapse", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate ROCKs", "RHO GTPases Activate ROCKs"], "9476": ["Surfactant metabolism"], "9477": ["PPARA activates gene expression", "Generic Transcription Pathway", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "948": ["Platelet degranulation ", "Cross-presentation of particulate exogenous antigens (phagosomes)", "ER-Phagosome pathway", "MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "Toll Like Receptor TLR6:TLR2 Cascade", "PPARA activates gene expression", "Scavenging by Class B Receptors", "Scavenging by Class B Receptors", "Transcriptional regulation of white adipocyte differentiation", "MyD88 deficiency (TLR2/4)", "IRAK4 deficiency (TLR2/4)", "Regulation of TLR by endogenous ligand", "Interleukin-4 and Interleukin-13 signaling", "Neutrophil degranulation"], "9481": ["The fatty acid cycling model", "The proton buffering model"], "9486": ["Reactions specific to the complex N-glycan synthesis pathway"], "9487": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "9488": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "9489": ["Synthesis of PG"], "949": ["Scavenging by Class B Receptors", "HDL clearance"], "9491": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "949101": ["Toll Like Receptor 5 (TLR5) Cascade", "MyD88 deficiency (TLR5)", "IRAK4 deficiency (TLR5)", "MyD88 cascade initiated on plasma membrane"], "9493": ["MHC class II antigen presentation", "COPI-dependent Golgi-to-ER retrograde traffic", "Mitotic Telophase/Cytokinesis", "Kinesins"], "9495": ["Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Trafficking of AMPA receptors", "ROBO receptors bind AKAP5", "ROBO receptors bind AKAP5"], "9497": ["Bicarbonate transporters"], "9498": ["Bicarbonate transporters"], "95": ["Aflatoxin activation and detoxification", "Defective ACY1 causes encephalopathy"], "950": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "9500": ["NRAGE signals death through JNK", "Caspase activation via Dependence Receptors in the absence of ligand"], "9507": ["Degradation of the extracellular matrix", "Degradation of the extracellular matrix", "Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "9508": ["Collagen biosynthesis and modifying enzymes", "Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "9509": ["Collagen biosynthesis and modifying enzymes", "Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "9510": ["Degradation of the extracellular matrix", "Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "9512": ["Mitochondrial protein import", "Processing of SMDT1"], "9517": ["Sphingolipid de novo biosynthesis"], "952": ["Nicotinate metabolism"], "9520": ["Antigen processing: Ubiquitination & Proteasome degradation"], "9521": ["SeMet incorporation into proteins", "Cytosolic tRNA aminoacylation"], "9522": ["Neutrophil degranulation"], "9524": ["Synthesis of very long-chain fatty acyl-CoAs"], "9525": ["Budding and maturation of HIV virion", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "9526": ["Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "Defective MPDU1 causes MPDU1-CDG (CDG-1f)"], "9527": ["COPI-mediated anterograde transport", "Intra-Golgi traffic"], "9529": ["Regulation of HSF1-mediated heat shock response"], "953": ["Phosphate bond hydrolysis by NTPDase proteins"], "9530": ["Regulation of HSF1-mediated heat shock response", "Signaling by FGFR1 in disease", "TNF signaling", "Signaling by plasma membrane FGFR1 fusions"], "9531": ["Regulation of HSF1-mediated heat shock response"], "9532": ["Regulation of HSF1-mediated heat shock response"], "9533": ["Cytosolic sensors of pathogen-associated DNA ", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase III Chain Elongation", "RNA Polymerase I Transcription Termination", "RNA Polymerase III Transcription Termination", "RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "9534": ["Generic Transcription Pathway"], "9535": ["Neutrophil degranulation"], "9536": ["Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"], "954": ["Phosphate bond hydrolysis by NTPDase proteins"], "9540": ["TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain"], "9542": ["Signaling by ERBB2", "Signaling by ERBB4", "SHC1 events in ERBB2 signaling", "SHC1 events in ERBB2 signaling", "PI3K events in ERBB4 signaling", "SHC1 events in ERBB4 signaling", "Nuclear signaling by ERBB4", "PIP3 activates AKT signaling", "GRB7 events in ERBB2 signaling", "Downregulation of ERBB2:ERBB3 signaling", "GRB2 events in ERBB2 signaling", "PI3K events in ERBB2 signaling", "Constitutive Signaling by Aberrant PI3K in Cancer", "RAF/MAP kinase cascade", "ERBB2 Regulates Cell Motility", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "ERBB2 Activates PTK6 Signaling", "Downregulation of ERBB2 signaling"], "9545": ["Neutrophil degranulation", "RAB geranylgeranylation"], "9546": ["Neurexins and neuroligins"], "955": ["Phosphate bond hydrolysis by NTPDase proteins"], "9550": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "9551": ["Formation of ATP by chemiosmotic coupling", "Cristae formation"], "9553": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "9554": ["ER-Phagosome pathway", "COPII-mediated vesicle transport", "Cargo concentration in the ER", "COPI-dependent Golgi-to-ER retrograde traffic"], "9557": ["Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER"], "9559": ["WNT ligand biogenesis and trafficking"], "956": ["Phosphate bond hydrolysis by NTPDase proteins"], "9560": ["G alpha (i) signalling events"], "9562": ["Synthesis of IPs in the ER lumen"], "9564": ["Downstream signal transduction", "p130Cas linkage to MAPK signaling for integrins", "VEGFA-VEGFR2 Pathway", "VEGFA-VEGFR2 Pathway", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases"], "956527": ["Influenza Life Cycle", "Entry of Influenza Virion into Host Cell via Endocytosis", "Fusion of the Influenza Virion to the Host Cell Endosome", "Release", "Budding", "Packaging of Eight RNA Segments", "Assembly of Viral Components at the Budding Site", "Viral RNP Complexes in the Host Cell Nucleus", "NEP/NS2 Interacts with the Cellular Export Machinery", "Uncoating of the Influenza Virion", "Viral mRNA Translation"], "956528": ["Influenza Life Cycle", "Entry of Influenza Virion into Host Cell via Endocytosis", "Fusion of the Influenza Virion to the Host Cell Endosome", "Release", "Budding", "Packaging of Eight RNA Segments", "Assembly of Viral Components at the Budding Site", "Uncoating of the Influenza Virion", "Transport of HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum to the Golgi Apparatus", "Viral mRNA Translation"], "956529": ["Influenza Life Cycle", "Entry of Influenza Virion into Host Cell via Endocytosis", "Fusion of the Influenza Virion to the Host Cell Endosome", "Release", "Budding", "Packaging of Eight RNA Segments", "Assembly of Viral Components at the Budding Site", "Uncoating of the Influenza Virion", "Transport of HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum to the Golgi Apparatus", "Viral mRNA Translation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "956530": ["Influenza Life Cycle", "Entry of Influenza Virion into Host Cell via Endocytosis", "Influenza Virus Induced Apoptosis", "Fusion of the Influenza Virion to the Host Cell Endosome", "Release", "Budding", "Packaging of Eight RNA Segments", "Assembly of Viral Components at the Budding Site", "Uncoating of the Influenza Virion", "Transport of HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum to the Golgi Apparatus", "Viral mRNA Translation"], "956531": ["Influenza Life Cycle", "Transport of Ribonucleoproteins into the Host Nucleus", "Entry of Influenza Virion into Host Cell via Endocytosis", "Fusion of the Influenza Virion to the Host Cell Endosome", "Release", "Budding", "Packaging of Eight RNA Segments", "Assembly of Viral Components at the Budding Site", "Viral Messenger RNA Synthesis", "Viral RNP Complexes in the Host Cell Nucleus", "NEP/NS2 Interacts with the Cellular Export Machinery", "Uncoating of the Influenza Virion", "vRNA Synthesis", "Viral mRNA Translation", "cRNA Synthesis", "vRNP Assembly"], "956532": ["Influenza Life Cycle", "Entry of Influenza Virion into Host Cell via Endocytosis", "Fusion of the Influenza Virion to the Host Cell Endosome", "Release", "Budding", "Packaging of Eight RNA Segments", "Viral RNP Complexes in the Host Cell Nucleus", "NEP/NS2 Interacts with the Cellular Export Machinery", "Uncoating of the Influenza Virion", "Viral mRNA Translation"], "956533": ["ISG15 antiviral mechanism", "NS1 Mediated Effects on Host Pathways", "Inhibition of Host mRNA Processing and RNA Silencing", "Inhibition of IFN-beta", "Inhibition of PKR", "Viral mRNA Translation"], "956534": ["Influenza Life Cycle", "Transport of Ribonucleoproteins into the Host Nucleus", "Entry of Influenza Virion into Host Cell via Endocytosis", "Fusion of the Influenza Virion to the Host Cell Endosome", "Release", "Budding", "Packaging of Eight RNA Segments", "Viral Messenger RNA Synthesis", "Viral RNP Complexes in the Host Cell Nucleus", "NEP/NS2 Interacts with the Cellular Export Machinery", "Uncoating of the Influenza Virion", "vRNA Synthesis", "Viral mRNA Translation", "cRNA Synthesis", "vRNP Assembly"], "956535": ["Influenza Life Cycle", "Transport of Ribonucleoproteins into the Host Nucleus", "Entry of Influenza Virion into Host Cell via Endocytosis", "Fusion of the Influenza Virion to the Host Cell Endosome", "Release", "Budding", "Packaging of Eight RNA Segments", "Viral Messenger RNA Synthesis", "Viral RNP Complexes in the Host Cell Nucleus", "NEP/NS2 Interacts with the Cellular Export Machinery", "Uncoating of the Influenza Virion", "vRNA Synthesis", "Viral mRNA Translation", "cRNA Synthesis", "vRNP Assembly"], "956536": ["Influenza Life Cycle", "Transport of Ribonucleoproteins into the Host Nucleus", "Entry of Influenza Virion into Host Cell via Endocytosis", "Fusion of the Influenza Virion to the Host Cell Endosome", "Release", "Budding", "Packaging of Eight RNA Segments", "Viral Messenger RNA Synthesis", "Viral RNP Complexes in the Host Cell Nucleus", "NEP/NS2 Interacts with the Cellular Export Machinery", "Uncoating of the Influenza Virion", "vRNA Synthesis", "Viral mRNA Translation", "cRNA Synthesis", "vRNP Assembly"], "9568": ["Activation of G protein gated Potassium channels", "G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)", "GABA B receptor activation", "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "95681": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "957": ["Phosphate bond hydrolysis by NTPDase proteins"], "9570": ["COPII-mediated vesicle transport", "XBP1(S) activates chaperone genes", "Cargo concentration in the ER", "COPI-mediated anterograde transport", "Intra-Golgi traffic"], "9572": ["NR1D1 (REV-ERBA) represses gene expression", "PPARA activates gene expression", "Transcriptional activation of mitochondrial biogenesis", "Nuclear Receptor transcription pathway", "Circadian Clock", "Circadian Clock"], "9575": ["BMAL1:CLOCK,NPAS2 activates circadian gene expression", "BMAL1:CLOCK,NPAS2 activates circadian gene expression", "PPARA activates gene expression", "HATs acetylate histones", "Circadian Clock"], "9577": ["Metalloprotease DUBs", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "G2/M DNA damage checkpoint"], "958": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "TNFR2 non-canonical NF-kB pathway", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "9580": ["Deactivation of the beta-catenin transactivating complex"], "9582": ["mRNA Editing: C to U Conversion", "Formation of the Editosome"], "9583": ["Phosphate bond hydrolysis by NTPDase proteins"], "9585": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "9588": ["Detoxification of Reactive Oxygen Species", "Neutrophil degranulation"], "9589": ["Processing of Capped Intron-Containing Pre-mRNA"], "959": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "TNFR2 non-canonical NF-kB pathway", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "960": ["Degradation of the extracellular matrix", "Cell surface interactions at the vascular wall", "Integrin cell surface interactions", "Hyaluronan uptake and degradation", "Neutrophil degranulation", "Interferon gamma signaling"], "9600": ["Synthesis of PI"], "9604": ["Antigen processing: Ubiquitination & Proteasome degradation"], "9609": ["Intra-Golgi traffic", "RAB geranylgeranylation"], "961": ["Cell surface interactions at the vascular wall", "Integrin cell surface interactions", "Signal regulatory protein family interactions", "Signal regulatory protein family interactions", "Neutrophil degranulation"], "9610": ["RAB GEFs exchange GTP for GDP on RABs"], "9611": ["Nuclear signaling by ERBB4", "Nuclear signaling by ERBB4", "NR1D1 (REV-ERBA) represses gene expression", "PPARA activates gene expression", "NOTCH1 Intracellular Domain Regulates Transcription", "Transcriptional activation of mitochondrial biogenesis", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "HDACs deacetylate histones", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)", "Circadian Clock", "Circadian Clock", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Loss of MECP2 binding ability to the NCoR/SMRT complex", "Regulation of MECP2 expression and activity"], "9612": ["PPARA activates gene expression", "NOTCH1 Intracellular Domain Regulates Transcription", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "HDACs deacetylate histones", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation", "SUMOylation of transcription cofactors", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)", "Loss of MECP2 binding ability to the NCoR/SMRT complex", "Regulation of MECP2 expression and activity"], "9615": ["Purine catabolism"], "9616": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "9619": ["ABC transporters in lipid homeostasis", "HDL remodeling"], "962": ["Cell surface interactions at the vascular wall"], "9626": ["Inactivation, recovery and regulation of the phototransduction cascade"], "9627": ["Amyloid fiber formation"], "9628": ["G alpha (i) signalling events", "G alpha (i) signalling events", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "963": ["Neutrophil degranulation"], "9630": ["Acetylcholine regulates insulin secretion", "Acetylcholine regulates insulin secretion", "G alpha (q) signalling events", "G alpha (q) signalling events", "ADP signalling through P2Y purinoceptor 1", "ADP signalling through P2Y purinoceptor 1", "Thromboxane signalling through TP receptor", "Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "Thrombin signalling through proteinase activated receptors (PARs)"], "9631": ["ISG15 antiviral mechanism", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "tRNA processing in the nucleus"], "9632": ["Regulation of cholesterol biosynthesis by SREBP (SREBF)", "COPII-mediated vesicle transport", "MHC class II antigen presentation", "Cargo concentration in the ER", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "9635": ["Stimuli-sensing channels"], "9636": ["ISG15 antiviral mechanism", "NS1 Mediated Effects on Host Pathways", "DDX58/IFIH1-mediated induction of interferon-alpha/beta", "Termination of translesion DNA synthesis", "Interferon alpha/beta signaling", "Negative regulators of DDX58/IFIH1 signaling"], "9639": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "9641": ["SUMOylation of immune response proteins", "TICAM1-dependent activation of IRF3/IRF7", "TRAF3-dependent IRF activation pathway", "TRAF6 mediated IRF7 activation", "Negative regulators of DDX58/IFIH1 signaling", "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon"], "9643": ["HATs acetylate histones"], "9644": ["Invadopodia formation"], "9646": ["Formation of RNA Pol II elongation complex ", "RNA Polymerase II Pre-transcription Events", "RNA Polymerase II Transcription Elongation", "E3 ubiquitin ligases ubiquitinate target proteins"], "9647": ["Negative regulation of NMDA receptor-mediated neuronal transmission"], "9648": ["Retrograde transport at the Trans-Golgi-Network"], "965": ["Cell surface interactions at the vascular wall", "Neutrophil degranulation"], "9651": ["Synthesis of IP3 and IP4 in the cytosol"], "9652": ["mRNA decay by 3' to 5' exoribonuclease"], "9653": ["HS-GAG biosynthesis"], "9654": ["Carboxyterminal post-translational modifications of tubulin"], "9655": ["Interleukin-4 and Interleukin-13 signaling", "Neddylation"], "9656": ["SUMOylation of DNA damage response and repair proteins", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "TP53 Regulates Transcription of DNA Repair Genes", "G2/M DNA damage checkpoint"], "9657": ["Anchoring of the basal body to the plasma membrane"], "966": ["COPII-mediated vesicle transport", "Cargo concentration in the ER", "Neutrophil degranulation", "COPI-mediated anterograde transport", "Regulation of Complement cascade"], "9662": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "9663": ["Synthesis of PC", "Synthesis of PE", "Depolymerisation of the Nuclear Lamina", "Triglyceride biosynthesis"], "9666": ["Antigen processing: Ubiquitination & Proteasome degradation"], "9668": ["Generic Transcription Pathway"], "9669": ["GTP hydrolysis and joining of the 60S ribosomal subunit"], "967": ["Platelet degranulation ", "Neutrophil degranulation"], "9672": ["A tetrasaccharide linker sequence is required for GAG synthesis", "HS-GAG biosynthesis", "HS-GAG biosynthesis", "HS-GAG degradation", "Cell surface interactions at the vascular wall", "Syndecan interactions", "Syndecan interactions", "Defective B4GALT7 causes EDS, progeroid type", "Defective B3GAT3 causes JDSSDHD", "Defective EXT2 causes exostoses 2", "Defective EXT1 causes exostoses 1, TRPS2 and CHDS", "Defective B3GALT6 causes EDSP2 and SEMDJL1", "Retinoid metabolism and transport"], "96764": ["RORA activates gene expression", "BMAL1:CLOCK,NPAS2 activates circadian gene expression", "snRNP Assembly", "PPARA activates gene expression", "PPARA activates gene expression", "Transcriptional activation of mitochondrial biogenesis", "Activation of gene expression by SREBF (SREBP)", "Transcriptional regulation of white adipocyte differentiation", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)", "Circadian Clock"], "9677": ["Synthesis of pyrophosphates in the cytosol"], "968": ["Neutrophil degranulation"], "9682": ["HDMs demethylate histones", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"], "9685": ["Golgi Associated Vesicle Biogenesis"], "9687": ["Estrogen-dependent gene expression"], "9688": ["ISG15 antiviral mechanism", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "tRNA processing in the nucleus"], "9690": ["Antigen processing: Ubiquitination & Proteasome degradation"], "9692": ["tRNA processing in the mitochondrion", "tRNA modification in the mitochondrion", "rRNA processing in the mitochondrion"], "9693": ["RAF/MAP kinase cascade"], "9695": ["XBP1(S) activates chaperone genes", "ER Quality Control Compartment (ERQC)"], "9698": ["Golgi Associated Vesicle Biogenesis"], "970": ["TNFs bind their physiological receptors"], "9700": ["Separation of Sister Chromatids"], "9702": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "9709": ["ATF4 activates genes"], "971": ["Other semaphorin interactions"], "9712": ["Retrograde transport at the Trans-Golgi-Network"], "9715": ["Signaling by BRAF and RAF fusions"], "9716": ["Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "mRNA Splicing - Major Pathway"], "9718": ["Peptide ligand-binding receptors"], "9719": ["Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "972": ["Cell surface interactions at the vascular wall", "MHC class II antigen presentation"], "9723": ["Other semaphorin interactions"], "9724": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "9725": ["Neutrophil degranulation"], "9727": ["VxPx cargo-targeting to cilium"], "973": ["CD22 mediated BCR regulation", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "9730": ["Antigen processing: Ubiquitination & Proteasome degradation"], "9732": ["Factors involved in megakaryocyte development and platelet production"], "9734": ["NOTCH1 Intracellular Domain Regulates Transcription", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants"], "9735": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "9736": ["TCF dependent signaling in response to WNT", "Ub-specific processing proteases"], "9738": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "Ub-specific processing proteases", "AURKA Activation by TPX2"], "9739": ["PKMTs methylate histone lysines", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"], "974": ["CD22 mediated BCR regulation", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "9742": ["Hedgehog 'off' state", "Intraflagellar transport"], "9743": ["Rho GTPase cycle"], "9749": ["Platelet degranulation "], "975": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Regulation of Complement cascade"], "9754": ["Rho GTPase cycle"], "9757": ["PKMTs methylate histone lysines", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"], "9759": ["NOTCH1 Intracellular Domain Regulates Transcription", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "SUMOylation of intracellular receptors", "SUMOylation of chromatin organization proteins", "RUNX2 regulates chondrocyte maturation", "RUNX3 regulates p14-ARF"], "976": ["Class B/2 (Secretin family receptors)", "Neutrophil degranulation"], "9761": ["N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "Neutrophil degranulation"], "9765": ["Signaling by BMP"], "9767": ["HATs acetylate histones"], "9768": ["Termination of translesion DNA synthesis"], "977": ["Assembly of collagen fibrils and other multimeric structures", "Type I hemidesmosome assembly"], "9775": ["Cleavage of Growing Transcript in the Termination Region ", "ISG15 antiviral mechanism", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Deadenylation of mRNA", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "9776": ["Macroautophagy"], "978": ["Neutrophil degranulation", "Pyrimidine salvage"], "9781": ["E3 ubiquitin ligases ubiquitinate target proteins"], "9785": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing"], "9787": ["NOTCH3 Intracellular Domain Regulates Transcription"], "9789": ["SRP-dependent cotranslational protein targeting to membrane", "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)", "Synthesis, secretion, and deacylation of Ghrelin"], "9790": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "9791": ["Synthesis of PS"], "9793": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "RHO GTPases Activate Formins", "Mitotic Prometaphase", "AURKA Activation by TPX2"], "9794": ["Pre-NOTCH Transcription and Translation", "Pre-NOTCH Transcription and Translation", "Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "NOTCH1 Intracellular Domain Regulates Transcription", "NOTCH1 Intracellular Domain Regulates Transcription", "NOTCH2 intracellular domain regulates transcription", "NOTCH2 intracellular domain regulates transcription", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "Notch-HLH transcription pathway", "RUNX3 regulates NOTCH signaling", "RUNX3 regulates NOTCH signaling", "NOTCH3 Intracellular Domain Regulates Transcription", "NOTCH3 Intracellular Domain Regulates Transcription", "NOTCH4 Intracellular Domain Regulates Transcription", "NOTCH4 Intracellular Domain Regulates Transcription"], "9797": ["XBP1(S) activates chaperone genes"], "9798": ["Neutrophil degranulation"], "9801": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "9804": ["Mitochondrial protein import", "Pink/Parkin Mediated Mitophagy", "Ub-specific processing proteases"], "9807": ["Synthesis of pyrophosphates in the cytosol", "Synthesis of IPs in the nucleus"], "9810": ["E3 ubiquitin ligases ubiquitinate target proteins"], "9814": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "9817": ["Ub-specific processing proteases", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "9818": ["ISG15 antiviral mechanism", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "tRNA processing in the nucleus"], "9820": ["XBP1(S) activates chaperone genes", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "9821": ["Macroautophagy"], "9824": ["Rho GTPase cycle"], "9826": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events", "Sema4D induced cell migration and growth-cone collapse"], "9827": ["Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network", "RAB GEFs exchange GTP for GDP on RABs"], "9828": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "9829": ["Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis", "Clathrin-mediated endocytosis"], "983": ["MAPK3 (ERK1) activation", "E2F-enabled inhibition of pre-replication complex formation", "Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1", "Golgi Cisternae Pericentriolar Stack Reorganization", "Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes", "APC/C:Cdc20 mediated degradation of Cyclin B", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Regulation of APC/C activators between G1/S and early anaphase", "Phosphorylation of the APC/C", "Phosphorylation of Emi1", "Condensation of Prophase Chromosomes", "MASTL Facilitates Mitotic Progression", "Resolution of Sister Chromatid Cohesion", "Condensation of Prometaphase Chromosomes", "Regulation of PLK1 Activity at G2/M Transition", "Activation of NIMA Kinases NEK9, NEK6, NEK7", "Nuclear Pore Complex (NPC) Disassembly", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Depolymerisation of the Nuclear Lamina", "Activation of E2F1 target genes at G1/S", "Anchoring of the basal body to the plasma membrane", "MAPK6/MAPK4 signaling", "Ovarian tumor domain proteases", "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "Regulation of TP53 Degradation", "Mitotic Prophase", "Cyclin A/B1/B2 associated events during G2/M transition", "Cyclin A/B1/B2 associated events during G2/M transition", "G2/M DNA replication checkpoint", "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "The role of GTSE1 in G2/M progression after G2 checkpoint", "AURKA Activation by TPX2", "Transcriptional regulation by RUNX2"], "9830": ["Interferon gamma signaling"], "9836": ["Synthesis of wybutosine at G37 of tRNA(Phe)", "Synthesis of wybutosine at G37 of tRNA(Phe)"], "9837": ["Unwinding of DNA", "Unwinding of DNA"], "984": ["Recruitment of mitotic centrosome proteins and complexes"], "9843": ["Metal ion SLC transporters", "Iron uptake and transport"], "9844": ["Nef and signal transduction", "Regulation of actin dynamics for phagocytic cup formation", "VEGFA-VEGFR2 Pathway", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases"], "9846": ["PI3K Cascade", "Signaling by SCF-KIT", "Signaling by cytosolic FGFR1 fusion mutants", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "RET signaling", "Interleukin-15 signaling", "Interleukin receptor SHC signaling"], "9847": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane"], "985151": ["InlA-mediated entry of Listeria monocytogenes into host cells"], "9855": ["SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion"], "9856": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "9861": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "Neutrophil degranulation", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "9862": ["PPARA activates gene expression", "Generic Transcription Pathway", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "9863": ["Nephrin family interactions"], "9867": ["Antigen processing: Ubiquitination & Proteasome degradation"], "9868": ["Mitochondrial protein import", "Pink/Parkin Mediated Mitophagy", "Ub-specific processing proteases"], "986892": ["InlB-mediated entry of Listeria monocytogenes into host cell", "InlB-mediated entry of Listeria monocytogenes into host cell"], "9869": ["PKMTs methylate histone lysines"], "9870": ["Antigen processing: Ubiquitination & Proteasome degradation"], "9871": ["Regulation of cholesterol biosynthesis by SREBP (SREBF)", "COPII-mediated vesicle transport", "MHC class II antigen presentation", "Cargo concentration in the ER", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "9877": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA 3'-end processing"], "9879": ["mRNA Splicing - Major Pathway"], "988": ["mRNA Splicing - Major Pathway"], "9882": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane"], "9883": ["ISG15 antiviral mechanism", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "tRNA processing in the nucleus"], "9885": ["Synthesis of bile acids and bile salts"], "9886": ["Rho GTPase cycle"], "9887": ["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "989": ["MAPK6/MAPK4 signaling"], "9890": ["Lysosphingolipid and LPA receptors"], "9891": ["Regulation of TP53 Activity through Phosphorylation"], "9892": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "9896": ["Synthesis of PIPs at the Golgi membrane", "Synthesis of PIPs at the Golgi membrane", "Synthesis of PIPs at the early endosome membrane", "Synthesis of PIPs at the early endosome membrane", "Synthesis of PIPs at the late endosome membrane", "Synthesis of PIPs at the late endosome membrane"], "9899": ["Toxicity of botulinum toxin type D (BoNT/D)", "Toxicity of botulinum toxin type A (BoNT/A)", "Toxicity of botulinum toxin type F (BoNT/F)", "Toxicity of botulinum toxin type E (BoNT/E)"], "990": ["Transcription of E2F targets under negative control by DREAM complex", "Activation of ATR in response to replication stress", "Activation of E2F1 target genes at G1/S", "CDC6 association with the ORC:origin complex", "CDT1 association with the CDC6:ORC:origin complex", "Assembly of the pre-replicative complex", "Orc1 removal from chromatin", "Activation of the pre-replicative complex", "CDK-mediated phosphorylation and removal of Cdc6"], "9900": ["Toxicity of botulinum toxin type D (BoNT/D)", "Toxicity of botulinum toxin type A (BoNT/A)", "Toxicity of botulinum toxin type F (BoNT/F)", "Toxicity of botulinum toxin type E (BoNT/E)"], "9901": ["Rho GTPase cycle", "Inactivation of CDC42 and RAC1"], "9902": ["Cross-presentation of soluble exogenous antigens (endosomes)", "Cross-presentation of soluble exogenous antigens (endosomes)"], "9903": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "9909": ["RAB GEFs exchange GTP for GDP on RABs"], "991": ["Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components", "Inactivation of APC/C via direct inhibition of the APC/C complex", "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "APC/C:Cdc20 mediated degradation of Cyclin B", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of Emi1", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Ub-specific processing proteases", "Mitotic Prometaphase", "Antigen processing: Ubiquitination & Proteasome degradation"], "9912": ["Rho GTPase cycle"], "9913": ["HATs acetylate histones"], "9914": ["Ion transport by P-type ATPases"], "9915": ["PPARA activates gene expression", "Phase I - Functionalization of compounds", "Endogenous sterols", "Xenobiotics", "Aryl hydrocarbon receptor signalling"], "9918": ["Condensation of Prometaphase Chromosomes", "Condensation of Prometaphase Chromosomes"], "9919": ["COPII-mediated vesicle transport"], "9924": ["Deadenylation of mRNA"], "9926": ["Acyl chain remodelling of PG"], "9927": ["Pink/Parkin Mediated Mitophagy", "Factors involved in megakaryocyte development and platelet production"], "9928": ["RHO GTPases activate CIT"], "9929": ["Josephin domain DUBs"], "993": ["Transcription of E2F targets under negative control by DREAM complex", "Polo-like kinase mediated events", "Activation of ATR in response to replication stress", "Ub-specific processing proteases", "Cyclin E associated events during G1/S transition ", "Cyclin A/B1/B2 associated events during G2/M transition", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "Cyclin A:Cdk2-associated events at S phase entry", "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models"], "9934": ["P2Y receptors", "G alpha (i) signalling events"], "9935": ["Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "9937": ["Fanconi Anemia Pathway"], "9938": ["Rho GTPase cycle"], "9939": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "994": ["Cyclin A/B1/B2 associated events during G2/M transition", "Cyclin A:Cdk2-associated events at S phase entry", "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models"], "9942": ["Formation of xylulose-5-phosphate"], "9945": ["Synthesis of UDP-N-acetyl-glucosamine"], "9948": ["Platelet degranulation "], "995": ["Polo-like kinase mediated events", "Activation of ATR in response to replication stress", "RHO GTPases activate PKNs", "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "Cyclin A/B1/B2 associated events during G2/M transition", "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models"], "9950": ["Intra-Golgi traffic"], "9951": ["HS-GAG biosynthesis"], "9953": ["HS-GAG biosynthesis"], "9955": ["HS-GAG biosynthesis"], "9956": ["HS-GAG biosynthesis"], "9957": ["HS-GAG biosynthesis"], "9958": ["Downregulation of TGF-beta receptor signaling", "UCH proteinases", "Ub-specific processing proteases"], "996": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6", "Antigen processing: Ubiquitination & Proteasome degradation"], "9960": ["Ub-specific processing proteases"], "9961": ["Neutrophil degranulation"], "9962": ["Vitamin C (ascorbate) metabolism"], "9963": ["Vitamin C (ascorbate) metabolism"], "9965": ["PI3K Cascade", "PIP3 activates AKT signaling", "betaKlotho-mediated ligand binding", "FGFR4 ligand binding and activation", "Constitutive Signaling by Aberrant PI3K in Cancer", "Phospholipase C-mediated cascade; FGFR4", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "PI-3K cascade:FGFR4", "Negative regulation of FGFR4 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "9966": ["TNFs bind their physiological receptors"], "9967": ["PPARA activates gene expression", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "9968": ["PPARA activates gene expression", "Generic Transcription Pathway", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "9969": ["PPARA activates gene expression", "Generic Transcription Pathway", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "997": ["Downstream TCR signaling", "FCERI mediated NF-kB activation", "CLEC7A (Dectin-1) signaling", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Antigen processing: Ubiquitination & Proteasome degradation"], "9970": ["Nuclear Receptor transcription pathway"], "9971": ["Recycling of bile acids and salts", "Synthesis of bile acids and bile salts", "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "PPARA activates gene expression", "Endogenous sterols", "Nuclear Receptor transcription pathway", "SUMOylation of intracellular receptors"], "9972": ["ISG15 antiviral mechanism", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "tRNA processing in the nucleus"], "9973": ["Detoxification of Reactive Oxygen Species", "Detoxification of Reactive Oxygen Species"], "9975": ["Nuclear Receptor transcription pathway"], "9976": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "9978": ["Recognition of DNA damage by PCNA-containing replication complex", "Prolactin receptor signaling", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Vif-mediated degradation of APOBEC3G", "Degradation of beta-catenin by the destruction complex", "NOTCH1 Intracellular Domain Regulates Transcription", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "Degradation of DVL", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "DNA Damage Recognition in GG-NER", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Orc1 removal from chromatin", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "998": ["GPVI-mediated activation cascade", "EGFR downregulation", "Rho GTPase cycle", "Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "CDO in myogenesis", "CDO in myogenesis", "CD28 dependent Vav1 pathway", "EPHB-mediated forward signaling", "EPHB-mediated forward signaling", "DCC mediated attractive signaling", "Inactivation of CDC42 and RAC1", "VEGFA-VEGFR2 Pathway", "RHO GTPases activate KTN1", "RHO GTPases activate IQGAPs", "RHO GTPases activate PAKs", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate Formins", "RHO GTPases Activate Formins", "MAPK6/MAPK4 signaling", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "G beta:gamma signalling through CDC42", "Factors involved in megakaryocyte development and platelet production"], "9982": ["FGFR2b ligand binding and activation"], "9984": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA 3'-end processing"], "9985": ["Meiotic synapsis"], "9986": ["Ub-specific processing proteases"], "9987": ["Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "999": ["Degradation of the extracellular matrix", "Degradation of the extracellular matrix", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Integrin cell surface interactions", "Apoptotic cleavage of cell adhesion proteins", "Adherens junctions interactions", "RHO GTPases activate IQGAPs", "InlA-mediated entry of Listeria monocytogenes into host cells"], "9990": ["Cation-coupled Chloride cotransporters", "Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)"], "9992": ["Phase 3 - rapid repolarisation", "Phase 2 - plateau phase"], "9994": ["SUMOylation of transcription cofactors"], "9997": ["TP53 Regulates Metabolic Genes", "Respiratory electron transport"], "NM_000077.4": ["Oxidative Stress Induced Senescence", "Oncogene Induced Senescence"], "NM_001244810": ["Transcriptional regulation of pluripotent stem cells"], "NM_058195.3": ["Oxidative Stress Induced Senescence", "Oncogene Induced Senescence", "RUNX3 regulates p14-ARF"], "NR_006880": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "NR_046235": ["NoRC negatively regulates rRNA expression", "rRNA modification in the nucleus and cytosol", "rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol", "RNA Polymerase I Transcription Termination"], "U13369": ["ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Transcription Termination", "RNA Polymerase I Transcription Termination"]}, "UniProt-AC": {"A0A075B6P5": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "A0A075B6S6": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "A0A0A6YYK7": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Downstream TCR signaling", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "PD-1 signaling"], "A0A0C4DH25": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "A0A0C4DH73": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "A0A183": ["Formation of the cornified envelope"], "A0AVF1": ["Intraflagellar transport", "Intraflagellar transport"], "A0AVI4": ["E3 ubiquitin ligases ubiquitinate target proteins"], "A0AVK6": ["TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest"], "A0AVT1": ["Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Antigen processing: Ubiquitination & Proteasome degradation"], "A0FGR8": ["Glycosphingolipid metabolism"], "A0FGR9": ["Glycosphingolipid metabolism"], "A0JLT2": ["PPARA activates gene expression", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "A0M8Q6": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "A0MZ66": ["Recycling pathway of L1"], "A0PJK1": ["Cellular hexose transport"], "A1A4S6": ["Rho GTPase cycle", "Regulation of PAK-2p34 activity by PS-GAP/RHG10"], "A1A580": ["Keratinization"], "A1A5B4": ["Stimuli-sensing channels"], "A1E959": ["Amyloid fiber formation"], "A1IGU5": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "A1L190": ["Meiotic synapsis"], "A1L3X0": ["Synthesis of very long-chain fatty acyl-CoAs"], "A1L4H1": ["Scavenging by Class B Receptors"], "A2KUC3": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "A2NJV5": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "A2NXD2": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "A2RRD8": ["Generic Transcription Pathway"], "A2RRP1": ["COPI-dependent Golgi-to-ER retrograde traffic"], "A2RU49": ["Lysine catabolism"], "A2RUC4": ["Synthesis of wybutosine at G37 of tRNA(Phe)"], "A2RUS2": ["RAB GEFs exchange GTP for GDP on RABs"], "A2VDF0": ["GDP-fucose biosynthesis"], "A2VEC9": ["Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "A3KFT3": ["Olfactory Signaling Pathway"], "A4D1E1": ["Generic Transcription Pathway"], "A4D1S5": ["RAB geranylgeranylation"], "A4D2G3": ["Olfactory Signaling Pathway"], "A4GXA9": ["Resolution of D-loop Structures through Holliday Junction Intermediates", "Fanconi Anemia Pathway"], "A5D6W6": ["Lipid particle organization"], "A5D8V6": ["Budding and maturation of HIV virion", "Membrane binding and targetting of GAG proteins", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "A5LHX3": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "A5PL33": ["Generic Transcription Pathway"], "A5PLK6": ["G alpha (q) signalling events", "G alpha (i) signalling events", "G alpha (z) signalling events"], "A5PLN9": ["RAB GEFs exchange GTP for GDP on RABs"], "A5X5Y0": ["Neurotransmitter receptors and postsynaptic signal transmission"], "A5YKK6": ["Deadenylation of mRNA", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "A5YM69": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "A5YM72": ["Histidine catabolism"], "A6H8Y1": ["RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "A6NCV1": ["Olfactory Signaling Pathway"], "A6NCW0": ["Ub-specific processing proteases"], "A6NCW7": ["Ub-specific processing proteases"], "A6ND01": ["Post-translational modification: synthesis of GPI-anchored proteins"], "A6ND48": ["Olfactory Signaling Pathway"], "A6NDG6": ["Glycolysis"], "A6NDH6": ["Olfactory Signaling Pathway"], "A6NDL8": ["Olfactory Signaling Pathway"], "A6NDX5": ["Generic Transcription Pathway"], "A6NET4": ["Olfactory Signaling Pathway"], "A6NF89": ["Olfactory Signaling Pathway"], "A6NFC9": ["Olfactory Signaling Pathway"], "A6NFH5": ["Triglyceride catabolism"], "A6NGB9": ["Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs"], "A6NGU5": ["Glutathione synthesis and recycling", "Aflatoxin activation and detoxification"], "A6NGY5": ["Olfactory Signaling Pathway"], "A6NH00": ["Olfactory Signaling Pathway"], "A6NH21": ["Serine biosynthesis"], "A6NHA9": ["Olfactory Signaling Pathway"], "A6NHC0": ["Degradation of the extracellular matrix"], "A6NHG9": ["Olfactory Signaling Pathway"], "A6NHJ4": ["Generic Transcription Pathway"], "A6NHL2": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "Gap junction assembly", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Recruitment of NuMA to mitotic centrosomes", "Formation of tubulin folding intermediates by CCT/TriC", "Post-chaperonin tubulin folding pathway", "Recycling pathway of L1", "Recycling pathway of L1", "Cilium Assembly", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "Carboxyterminal post-translational modifications of tubulin", "Carboxyterminal post-translational modifications of tubulin", "Activation of AMPK downstream of NMDARs", "Kinesins"], "A6NI28": ["Rho GTPase cycle"], "A6NI73": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "A6NIH7": ["Trafficking of myristoylated proteins to the cilium"], "A6NIJ9": ["Olfactory Signaling Pathway"], "A6NIX2": ["Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"], "A6NJZ3": ["Olfactory Signaling Pathway"], "A6NK53": ["Generic Transcription Pathway"], "A6NK58": ["Glyoxylate metabolism and glycine degradation"], "A6NK59": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "A6NKK0": ["Olfactory Signaling Pathway"], "A6NL08": ["Olfactory Signaling Pathway"], "A6NL26": ["Olfactory Signaling Pathway"], "A6NLF2": ["Formation of RNA Pol II elongation complex ", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "RNA Polymerase II Transcription Elongation"], "A6NM03": ["Olfactory Signaling Pathway"], "A6NM76": ["Olfactory Signaling Pathway"], "A6NMB1": ["DAP12 interactions"], "A6NMS3": ["Olfactory Signaling Pathway"], "A6NMU1": ["Olfactory Signaling Pathway"], "A6NMZ5": ["Olfactory Signaling Pathway"], "A6NMZ7": ["Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Signaling by PDGF", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "ECM proteoglycans", "ECM proteoglycans", "NCAM1 interactions", "Collagen chain trimerization"], "A6NN14": ["Generic Transcription Pathway"], "A6NND4": ["Olfactory Signaling Pathway"], "A6NNF4": ["Generic Transcription Pathway"], "A6NNM8": ["Carboxyterminal post-translational modifications of tubulin"], "A6NNZ2": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "Gap junction assembly", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Recruitment of NuMA to mitotic centrosomes", "Recycling pathway of L1", "Recycling pathway of L1", "Cilium Assembly", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "Carboxyterminal post-translational modifications of tubulin", "Carboxyterminal post-translational modifications of tubulin", "Activation of AMPK downstream of NMDARs", "Kinesins"], "A6NP11": ["Generic Transcription Pathway"], "A6PVC2": ["Carboxyterminal post-translational modifications of tubulin"], "A7E2V4": ["Regulation of expression of SLITs and ROBOs"], "A7KAX9": ["Rho GTPase cycle"], "A7MBM2": ["Release of Hh-Np from the secreting cell", "Release of Hh-Np from the secreting cell"], "A8CG34": ["ISG15 antiviral mechanism", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "tRNA processing in the nucleus"], "A8K0R7": ["Generic Transcription Pathway"], "A8K4G0": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "DAP12 interactions"], "A8K7I4": ["Stimuli-sensing channels"], "A8K855": ["Activation of SMO"], "A8K8P3": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "A8K8V0": ["Generic Transcription Pathway"], "A8MPY1": ["GABA A (rho) receptor activation"], "A8MQ27": ["Activated NOTCH1 Transmits Signal to the Nucleus", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "NOTCH2 Activation and Transmission of Signal to the Nucleus", "NOTCH3 Activation and Transmission of Signal to the Nucleus"], "A8MT69": ["Deposition of new CENPA-containing nucleosomes at the centromere", "Fanconi Anemia Pathway"], "A8MTJ3": ["PLC beta mediated events", "PLC beta mediated events", "Adenylate cyclase inhibitory pathway", "Adenylate cyclase inhibitory pathway", "G-protein activation", "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "ADP signalling through P2Y purinoceptor 12", "G alpha (s) signalling events", "G alpha (i) signalling events", "G alpha (i) signalling events", "G alpha (z) signalling events", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "A8MTY0": ["Generic Transcription Pathway"], "A8MTY7": ["Keratinization"], "A8MTZ0": ["BBSome-mediated cargo-targeting to cilium"], "A8MUK1": ["Ub-specific processing proteases"], "A8MUV8": ["Generic Transcription Pathway"], "A8MUX0": ["Keratinization"], "A8MUZ8": ["Generic Transcription Pathway"], "A8MVA2": ["Keratinization"], "A8MVS1": ["Generic Transcription Pathway"], "A8MVX0": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "A8MWA4": ["Generic Transcription Pathway"], "A8MX34": ["Keratinization"], "A8MX76": ["Degradation of the extracellular matrix"], "A8MXU0": ["Beta defensins"], "A8MXV4": ["Peroxisomal lipid metabolism", "Peroxisomal protein import", "Peroxisomal protein import"], "A8MXY4": ["Generic Transcription Pathway"], "A8MXZ3": ["Keratinization"], "A8MYU2": ["Sperm Motility And Taxes"], "A8MYZ6": ["AKT phosphorylates targets in the nucleus", "Constitutive Signaling by AKT1 E17K in Cancer", "Regulation of localization of FOXO transcription factors", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes"], "A8TX70": ["Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Signaling by PDGF", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "ECM proteoglycans", "ECM proteoglycans", "NCAM1 interactions", "Collagen chain trimerization"], "A9QM74": ["ISG15 antiviral mechanism", "NS1 Mediated Effects on Host Pathways"], "A9YTQ3": ["PPARA activates gene expression", "Phase I - Functionalization of compounds", "Endogenous sterols", "Xenobiotics", "Aryl hydrocarbon receptor signalling"], "B0YJ81": ["Synthesis of very long-chain fatty acyl-CoAs"], "B1NKT1": ["OAS antiviral response"], "B2RTY4": ["Rho GTPase cycle"], "B4DX44": ["Generic Transcription Pathway"], "B4DXR9": ["Generic Transcription Pathway"], "B6A8C7": ["Neutrophil degranulation"], "B7ZC32": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "C9J2P7": ["Ub-specific processing proteases"], "C9JJH3": ["Ub-specific processing proteases"], "C9JLJ4": ["Ub-specific processing proteases"], "C9JPN9": ["Ub-specific processing proteases"], "C9JR72": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "C9JRZ8": ["Estrogen biosynthesis"], "C9JVI0": ["Ub-specific processing proteases"], "D6R901": ["Ub-specific processing proteases"], "D6R9N7": ["Ub-specific processing proteases"], "D6RA61": ["Ub-specific processing proteases"], "D6RBQ6": ["Ub-specific processing proteases"], "D6RCP7": ["Ub-specific processing proteases"], "D6RJB6": ["Ub-specific processing proteases"], "O00115": ["Lysosome Vesicle Biogenesis"], "O00116": ["Plasmalogen biosynthesis", "Peroxisomal protein import", "Peroxisomal protein import", "TYSND1 cleaves peroxisomal proteins"], "O00139": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "COPI-dependent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "Kinesins"], "O00141": ["Stimuli-sensing channels", "Regulation of TP53 Degradation", "Transcriptional Regulation by MECP2"], "O00142": ["Pyrimidine salvage"], "O00144": ["Class B/2 (Secretin family receptors)"], "O00148": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA 3'-end processing"], "O00154": ["Mitochondrial Fatty Acid Beta-Oxidation"], "O00155": ["G alpha (s) signalling events"], "O00159": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Regulation of actin dynamics for phagocytic cup formation"], "O00159-3": ["B-WICH complex positively regulates rRNA expression"], "O00161": ["ER-Phagosome pathway", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Clathrin derived vesicle budding", "Neutrophil degranulation"], "O00167": ["Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"], "O00168": ["Ion homeostasis", "Ion transport by P-type ATPases"], "O00170": ["Aryl hydrocarbon receptor signalling", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "O00180": ["Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)", "Phase 4 - resting membrane potential"], "O00182": ["Interleukin-2 family signaling"], "O00186": ["Disinhibition of SNARE formation", "Translocation of SLC2A4 (GLUT4) to the plasma membrane"], "O00187-1": ["Lectin pathway of complement activation", "Initial triggering of complement", "Ficolins bind to repetitive carbohydrate structures on the target cell surface"], "O00189": ["Lysosome Vesicle Biogenesis"], "O00194": ["Platelet degranulation ", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "O00203": ["Golgi Associated Vesicle Biogenesis", "Signaling by BRAF and RAF fusions"], "O00204-1": ["Cytosolic sulfonation of small molecules"], "O00204-2": ["Cytosolic sulfonation of small molecules"], "O00206": ["ER-Phagosome pathway", "Caspase activation via Death Receptors in the presence of ligand", "Toll Like Receptor 4 (TLR4) Cascade", "MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "MyD88-independent TLR4 cascade ", "TRIF-mediated programmed cell death", "MyD88 deficiency (TLR2/4)", "IRAK4 deficiency (TLR2/4)", "Regulation of TLR by endogenous ligand", "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon", "IKK complex recruitment mediated by RIP1", "TRAF6-mediated induction of TAK1 complex within TLR4 complex", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"], "O00212": ["Rho GTPase cycle", "RHO GTPases Activate Formins"], "O00213": ["Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"], "O00217": ["Respiratory electron transport", "Complex I biogenesis"], "O00219": ["Hyaluronan biosynthesis and export"], "O00220": ["Caspase activation via Death Receptors in the presence of ligand", "Cell surface interactions at the vascular wall", "Regulation by c-FLIP", "RIPK1-mediated regulated necrosis", "CASP8 activity is inhibited", "TP53 Regulates Transcription of Death Receptors and Ligands", "Dimerization of procaspase-8", "TRAIL signaling"], "O00221": ["Activation of NF-kappaB in B cells"], "O00222": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "O00230": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "O00231": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "Neutrophil degranulation", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "O00232": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "Neutrophil degranulation", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "O00233": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "O00237": ["ER Quality Control Compartment (ERQC)"], "O00238": ["Signaling by BMP"], "O00241": ["DAP12 interactions", "Signal regulatory protein family interactions", "Neutrophil degranulation"], "O00244": ["Detoxification of Reactive Oxygen Species", "Ion influx/efflux at host-pathogen interface"], "O00253": ["FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes"], "O00254": ["Peptide ligand-binding receptors", "G alpha (q) signalling events", "Thrombin signalling through proteinase activated receptors (PARs)", "Thrombin signalling through proteinase activated receptors (PARs)"], "O00255": ["Formation of the beta-catenin:TCF transactivating complex", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Deactivation of the beta-catenin transactivating complex", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "RHO GTPases activate IQGAPs", "Post-translational protein phosphorylation"], "O00257": ["Oxidative Stress Induced Senescence", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of transcription cofactors", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA methylation proteins", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription"], "O00264": ["Neutrophil degranulation"], "O00267": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Abortive elongation of HIV-1 transcript in the absence of Tat", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "RNA Polymerase II Transcription Elongation", "RNA Pol II CTD phosphorylation and interaction with CE"], "O00268": ["HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "O00270": ["G alpha (i) signalling events", "Free fatty acid receptors"], "O00273": ["Activation of DNA fragmentation factor"], "O00291": ["Clathrin-mediated endocytosis"], "O00292": ["Platelet degranulation ", "Signaling by NODAL", "Regulation of signaling by NODAL"], "O00300": ["TNFs bind their physiological receptors"], "O00303": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "O00305": ["Presynaptic depolarization and calcium channel opening", "NCAM1 interactions", "Phase 0 - rapid depolarisation", "Phase 2 - plateau phase"], "O00308": ["Regulation of PTEN stability and activity", "NOTCH3 Activation and Transmission of Signal to the Nucleus"], "O00311": ["Activation of ATR in response to replication stress", "Activation of the pre-replicative complex", "Transcriptional Regulation by E2F6"], "O00327": ["BMAL1:CLOCK,NPAS2 activates circadian gene expression", "BMAL1:CLOCK,NPAS2 activates circadian gene expression", "PPARA activates gene expression", "Circadian Clock"], "O00329": ["PIP3 activates AKT signaling", "Synthesis of PIPs at the plasma membrane", "Constitutive Signaling by Aberrant PI3K in Cancer", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "RET signaling", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "Interleukin receptor SHC signaling", "Regulation of signaling by CBL", "Regulation of signaling by CBL", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "O00330": ["Regulation of pyruvate dehydrogenase (PDH) complex", "Glyoxylate metabolism and glycine degradation", "Signaling by Retinoic Acid", "Pyruvate metabolism"], "O00337": ["Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"], "O00338": ["Cytosolic sulfonation of small molecules"], "O00341": ["Glutamate Neurotransmitter Release Cycle", "Transport of inorganic cations/anions and amino acids/oligopeptides"], "O00391": ["Platelet degranulation ", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Neutrophil degranulation", "Post-translational protein phosphorylation"], "O00398": ["G alpha (q) signalling events", "P2Y receptors"], "O00399": ["MHC class II antigen presentation", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic"], "O00400": ["Transport of vitamins, nucleosides, and related molecules", "Defective SLC33A1 causes spastic paraplegia 42 (SPG42)"], "O00401": ["Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "NOSTRIN mediated eNOS trafficking", "Nephrin family interactions", "EPHB-mediated forward signaling", "EPHB-mediated forward signaling", "DCC mediated attractive signaling", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs", "Clathrin-mediated endocytosis"], "O00408": ["cGMP effects", "G alpha (s) signalling events"], "O00410": ["vRNP Assembly"], "O00411": ["Mitochondrial transcription initiation", "Transcriptional activation of mitochondrial biogenesis"], "O00418": ["mTORC1-mediated signalling"], "O00421": ["Chemokine receptors bind chemokines"], "O00422": ["HDACs deacetylate histones", "NoRC negatively regulates rRNA expression"], "O00425": ["Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA"], "O00429": ["Apoptotic execution phase"], "O00443": ["Synthesis of PIPs at the plasma membrane", "Synthesis of PIPs at the Golgi membrane", "Synthesis of PIPs at the early endosome membrane", "Synthesis of PIPs at the late endosome membrane", "Golgi Associated Vesicle Biogenesis", "Clathrin-mediated endocytosis"], "O00444": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "O00445": ["Regulation of insulin secretion"], "O00451": ["NCAM1 interactions", "RAF/MAP kinase cascade", "RET signaling"], "O00459": ["PI3K Cascade", "IRS-mediated signalling", "GPVI-mediated activation cascade", "PIP3 activates AKT signaling", "Interleukin-7 signaling", "Interleukin-7 signaling", "Signaling by SCF-KIT", "Synthesis of PIPs at the plasma membrane", "Downstream signal transduction", "Rho GTPase cycle", "PI3K/AKT activation", "Downstream TCR signaling", "Role of phospholipids in phagocytosis", "Tie2 Signaling", "Constitutive Signaling by Aberrant PI3K in Cancer", "DAP12 signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Nephrin family interactions", "Costimulation by the CD28 family", "CD28 dependent PI3K/Akt signaling", "G alpha (q) signalling events", "VEGFA-VEGFR2 Pathway", "VEGFA-VEGFR2 Pathway", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "RET signaling", "Interleukin receptor SHC signaling", "Regulation of signaling by CBL", "Regulation of signaling by CBL"], "O00461": ["Intra-Golgi traffic"], "O00462": ["Neutrophil degranulation", "Lysosomal oligosaccharide catabolism"], "O00468": ["A tetrasaccharide linker sequence is required for GAG synthesis", "HS-GAG biosynthesis", "HS-GAG biosynthesis", "HS-GAG degradation", "Integrin cell surface interactions", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "ECM proteoglycans", "Defective B4GALT7 causes EDS, progeroid type", "Defective B3GAT3 causes JDSSDHD", "Defective EXT2 causes exostoses 2", "Defective EXT1 causes exostoses 1, TRPS2 and CHDS", "NCAM1 interactions", "Defective B3GALT6 causes EDSP2 and SEMDJL1", "Retinoid metabolism and transport"], "O00469": ["Collagen biosynthesis and modifying enzymes"], "O00470": ["Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "O00471": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Insulin processing", "VxPx cargo-targeting to cilium"], "O00472": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes"], "O00476": ["Stimuli-sensing channels"], "O00478": ["Butyrophilin (BTN) family interactions"], "O00481": ["Butyrophilin (BTN) family interactions"], "O00482": ["Estrogen-dependent gene expression"], "O00482-1": ["Regulation of gene expression in early pancreatic precursor cells", "Nuclear Receptor transcription pathway"], "O00482-2": ["Nuclear Receptor transcription pathway", "SUMOylation of intracellular receptors"], "O00482-3": ["Nuclear Receptor transcription pathway"], "O00483": ["TP53 Regulates Metabolic Genes", "Respiratory electron transport"], "O00487": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "Metalloprotease DUBs", "Neutrophil degranulation", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "O00499": ["Clathrin-mediated endocytosis"], "O00501": ["Tight junction interactions", "RUNX1 regulates expression of components of tight junctions"], "O00505": ["ISG15 antiviral mechanism", "NS1 Mediated Effects on Host Pathways"], "O00512": ["Formation of the beta-catenin:TCF transactivating complex", "Deactivation of the beta-catenin transactivating complex"], "O00519": ["Arachidonic acid metabolism"], "O00533": ["CHL1 interactions"], "O00541": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "O00548": ["Activated NOTCH1 Transmits Signal to the Nucleus", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant", "Constitutive Signaling by NOTCH1 HD Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "NOTCH2 Activation and Transmission of Signal to the Nucleus", "NOTCH3 Activation and Transmission of Signal to the Nucleus", "NOTCH3 Activation and Transmission of Signal to the Nucleus", "MECP2 regulates transcription of neuronal ligands"], "O00555": ["Presynaptic depolarization and calcium channel opening", "Regulation of insulin secretion"], "O00559": ["Estrogen-dependent gene expression"], "O00560": ["Ephrin signaling", "Neurofascin interactions", "Neutrophil degranulation"], "O00562": ["Synthesis of PI"], "O00566": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "O00567": ["Association of TriC/CCT with target proteins during biosynthesis", "rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "O00571": ["Neutrophil degranulation"], "O00574": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "O00584": ["Neutrophil degranulation"], "O00585": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "O00587": ["Pre-NOTCH Processing in Golgi"], "O00602": ["Lectin pathway of complement activation", "Initial triggering of complement", "Ficolins bind to repetitive carbohydrate structures on the target cell surface", "Neutrophil degranulation"], "O00622": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "O00623": ["E3 ubiquitin ligases ubiquitinate target proteins", "Peroxisomal protein import", "Peroxisomal protein import"], "O00625": ["Digestion"], "O00626": ["Interleukin-10 signaling", "Interleukin-4 and Interleukin-13 signaling"], "O00628": ["Peroxisomal protein import", "Peroxisomal protein import"], "O00629": ["ISG15 antiviral mechanism", "NS1 Mediated Effects on Host Pathways"], "O00631": ["Ion homeostasis", "Ion transport by P-type ATPases"], "O00634": ["CDO in myogenesis"], "O00635": ["Interferon gamma signaling"], "O00712": ["RNA Polymerase III Transcription Termination", "RNA Polymerase III Abortive And Retractive Initiation"], "O00716": ["Pre-NOTCH Transcription and Translation", "Pre-NOTCH Transcription and Translation", "Oxidative Stress Induced Senescence", "Oncogene Induced Senescence", "CDC6 association with the ORC:origin complex", "G2 Phase", "Cyclin D associated events in G1"], "O00743": ["COPII-mediated vesicle transport"], "O00744": ["WNT ligand biogenesis and trafficking", "WNT ligand biogenesis and trafficking", "Class B/2 (Secretin family receptors)", "Transcriptional regulation of white adipocyte differentiation"], "O00746": ["Interconversion of nucleotide di- and triphosphates"], "O00748": ["Phase I - Functionalization of compounds"], "O00750": ["Synthesis of PIPs at the plasma membrane"], "O00754": ["Neutrophil degranulation", "Lysosomal oligosaccharide catabolism"], "O00755": ["WNT ligand biogenesis and trafficking", "WNT ligand biogenesis and trafficking", "Class B/2 (Secretin family receptors)"], "O00757": ["Gluconeogenesis"], "O00762": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Antigen processing: Ubiquitination & Proteasome degradation"], "O00763": ["ChREBP activates metabolic gene expression", "Biotin transport and metabolism", "Import of palmitoyl-CoA into the mitochondrial matrix", "Activation of gene expression by SREBF (SREBP)"], "O00764": ["Neutrophil degranulation", "Vitamins B6 activation to pyridoxal phosphate"], "O00767": ["Activation of gene expression by SREBF (SREBP)", "Fatty acyl-CoA biosynthesis"], "O14490": ["Neurexins and neuroligins", "Neurexins and neuroligins"], "O14492": ["Regulation of KIT signaling", "Factors involved in megakaryocyte development and platelet production"], "O14493": ["Tight junction interactions"], "O14494": ["Sphingolipid de novo biosynthesis"], "O14495": ["Sphingolipid de novo biosynthesis"], "O14497": ["RMTs methylate histone arginines", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "O14498": ["Platelet degranulation "], "O14503": ["BMAL1:CLOCK,NPAS2 activates circadian gene expression"], "O14508": ["Interleukin-7 signaling", "Neddylation", "Growth hormone receptor signaling"], "O14511": ["Signaling by ERBB2", "Signaling by ERBB4", "SHC1 events in ERBB2 signaling", "SHC1 events in ERBB2 signaling", "PI3K events in ERBB4 signaling", "SHC1 events in ERBB4 signaling", "Nuclear signaling by ERBB4", "PIP3 activates AKT signaling", "GRB7 events in ERBB2 signaling", "Downregulation of ERBB2:ERBB3 signaling", "GRB2 events in ERBB2 signaling", "PI3K events in ERBB2 signaling", "Constitutive Signaling by Aberrant PI3K in Cancer", "RAF/MAP kinase cascade", "ERBB2 Regulates Cell Motility", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "ERBB2 Activates PTK6 Signaling", "Downregulation of ERBB2 signaling"], "O14520": ["Transport of glycerol from adipocytes to the liver by Aquaporins", "Passive transport by Aquaporins"], "O14521": ["Respiratory electron transport", "Citric acid cycle (TCA cycle)"], "O14526": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "O14531": ["CRMPs in Sema3A signaling"], "O14543": ["Interleukin-6 signaling", "Signaling by Leptin", "Interleukin-4 and Interleukin-13 signaling", "Interferon gamma signaling", "Regulation of IFNG signaling", "PTK6 Activates STAT3", "RUNX1 regulates transcription of genes involved in differentiation of keratinocytes", "Neddylation", "Interferon alpha/beta signaling", "Regulation of IFNA signaling", "Growth hormone receptor signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "O14544": ["Regulation of KIT signaling", "Neddylation"], "O14548": ["TP53 Regulates Metabolic Genes", "Respiratory electron transport"], "O14556": ["Association of TriC/CCT with target proteins during biosynthesis", "Glycolysis", "Gluconeogenesis"], "O14559": ["Rho GTPase cycle"], "O14561": ["Glyoxylate metabolism and glycine degradation", "Respiratory electron transport", "Complex I biogenesis", "Mitochondrial Fatty Acid Beta-Oxidation"], "O14576": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase"], "O14578": ["RHO GTPases activate CIT", "RHO GTPases activate CIT"], "O14578-3": ["RHO GTPases activate CIT", "RHO GTPases activate CIT"], "O14579": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "O14581": ["Olfactory Signaling Pathway"], "O14594": ["A tetrasaccharide linker sequence is required for GAG synthesis", "Chondroitin sulfate biosynthesis", "Dermatan sulfate biosynthesis", "CS/DS degradation", "ECM proteoglycans", "Defective B4GALT7 causes EDS, progeroid type", "Defective B3GAT3 causes JDSSDHD", "Defective CHST3 causes SEDCJD", "Defective CHST14 causes EDS, musculocontractural type", "Defective CHSY1 causes TPBS", "L1CAM interactions", "NCAM1 interactions", "Defective B3GALT6 causes EDSP2 and SEMDJL1"], "O14595": ["XBP1(S) activates chaperone genes"], "O14607": ["HDMs demethylate histones"], "O14610": ["Activation of G protein gated Potassium channels", "G-protein activation", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42", "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "O14613": ["MAPK6/MAPK4 signaling"], "O14618": ["Detoxification of Reactive Oxygen Species", "Detoxification of Reactive Oxygen Species"], "O14625": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "O14628": ["Generic Transcription Pathway"], "O14633": ["Formation of the cornified envelope"], "O14638": ["Vitamin B5 (pantothenate) metabolism"], "O14639": ["DCC mediated attractive signaling"], "O14640": ["TCF dependent signaling in response to WNT", "WNT mediated activation of DVL", "PCP/CE pathway", "PCP/CE pathway", "Degradation of DVL", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Negative regulation of TCF-dependent signaling by DVL-interacting proteins", "RHO GTPases Activate Formins"], "O14641": ["TCF dependent signaling in response to WNT", "WNT mediated activation of DVL", "Signaling by Hippo", "PCP/CE pathway", "PCP/CE pathway", "Asymmetric localization of PCP proteins", "Degradation of DVL", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "WNT5A-dependent internalization of FZD4", "Negative regulation of TCF-dependent signaling by DVL-interacting proteins", "RHO GTPases Activate Formins", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "O14646": ["Estrogen-dependent gene expression"], "O14649": ["TWIK-releated acid-sensitive K+ channel (TASK)", "Phase 4 - resting membrane potential"], "O14653": ["COPII-mediated vesicle transport", "XBP1(S) activates chaperone genes", "Cargo concentration in the ER", "COPI-mediated anterograde transport", "Intra-Golgi traffic"], "O14654": ["IRS-related events triggered by IGF1R"], "O14656": ["Cargo recognition for clathrin-mediated endocytosis"], "O14657": ["Cargo recognition for clathrin-mediated endocytosis"], "O14662": ["Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network"], "O14672": ["Collagen degradation", "Degradation of the extracellular matrix", "Signaling by EGFR", "Activated NOTCH1 Transmits Signal to the Nucleus", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant", "Constitutive Signaling by NOTCH1 HD Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "NOTCH2 Activation and Transmission of Signal to the Nucleus", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "EPH-ephrin mediated repulsion of cells", "Neutrophil degranulation", "Post-translational protein phosphorylation", "NOTCH3 Activation and Transmission of Signal to the Nucleus", "NOTCH4 Activation and Transmission of Signal to the Nucleus", "Amyloid fiber formation"], "O14678": ["Cobalamin (Cbl, vitamin B12) transport and metabolism", "Defective ABCD4 causes methylmalonic aciduria and homocystinuria, cblj type (MAHCJ)"], "O14684": ["Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"], "O14686": ["Formation of the beta-catenin:TCF transactivating complex", "PKMTs methylate histone lysines", "Deactivation of the beta-catenin transactivating complex", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"], "O14709": ["Generic Transcription Pathway"], "O14717": ["tRNA modification in the nucleus and cytosol"], "O14718": ["G alpha (i) signalling events", "Opsins"], "O14727": ["Formation of apoptosome", "Activation of caspases through apoptosome-mediated cleavage", "SMAC (DIABLO) binds to IAPs ", "SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ", "Neutrophil degranulation", "TP53 Regulates Transcription of Caspase Activators and Caspases", "Transcriptional Regulation by E2F6", "Regulation of the apoptosome activity", "Regulation of the apoptosome activity"], "O14730": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "O14732": ["Synthesis of IP2, IP, and Ins in the cytosol"], "O14733": ["Oxidative Stress Induced Senescence", "FCERI mediated MAPK activation", "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "Uptake and function of anthrax toxins"], "O14734": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "alpha-linolenic acid (ALA) metabolism", "Beta-oxidation of pristanoyl-CoA", "Beta-oxidation of very long chain fatty acids", "Peroxisomal protein import", "Peroxisomal protein import"], "O14735": ["Synthesis of PI"], "O14744": ["snRNP Assembly", "RMTs methylate histone arginines", "Regulation of TP53 Activity through Methylation"], "O14746": ["Telomere Extension By Telomerase", "Formation of the beta-catenin:TCF transactivating complex"], "O14756": ["The canonical retinoid cycle in rods (twilight vision)"], "O14757": ["Signaling by SCF-KIT", "Activation of ATR in response to replication stress", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "TP53 Regulates Transcription of DNA Repair Genes", "Regulation of TP53 Activity through Phosphorylation", "G2/M DNA damage checkpoint", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "Transcriptional Regulation by E2F6"], "O14763": ["Caspase activation via Death Receptors in the presence of ligand", "Cell surface interactions at the vascular wall", "Regulation by c-FLIP", "RIPK1-mediated regulated necrosis", "CASP8 activity is inhibited", "TP53 Regulates Transcription of Death Receptors and Ligands", "Dimerization of procaspase-8", "TRAIL signaling"], "O14771": ["Generic Transcription Pathway"], "O14772": ["GDP-fucose biosynthesis"], "O14773": ["XBP1(S) activates chaperone genes"], "O14775": ["G-protein activation", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42"], "O14775-1": ["Inactivation, recovery and regulation of the phototransduction cascade", "Inactivation, recovery and regulation of the phototransduction cascade"], "O14777": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "O14782": ["MHC class II antigen presentation", "Intraflagellar transport", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins", "Kinesins"], "O14786": ["Neurophilin interactions with VEGF and VEGFR", "Signaling by ROBO receptors", "Sema3A PAK dependent Axon repulsion", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "CRMPs in Sema3A signaling", "CRMPs in Sema3A signaling", "Signal transduction by L1", "CHL1 interactions"], "O14788": ["TNFR2 non-canonical NF-kB pathway", "TNFs bind their physiological receptors", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "O14791": ["Scavenging of heme from plasma", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "O14792": ["HS-GAG biosynthesis"], "O14793": ["FOXO-mediated transcription of cell cycle genes"], "O14795": ["Serotonin Neurotransmitter Release Cycle", "Norepinephrine Neurotransmitter Release Cycle", "Glutamate Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle", "Acetylcholine Neurotransmitter Release Cycle"], "O14796": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "O14798": ["TP53 Regulates Transcription of Death Receptors and Ligands"], "O14802": ["Cytosolic sensors of pathogen-associated DNA ", "RNA Polymerase III Chain Elongation", "RNA Polymerase III Transcription Termination", "RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "O14804": ["Amine ligand-binding receptors", "G alpha (s) signalling events"], "O14810": ["Serotonin Neurotransmitter Release Cycle", "Norepinephrine Neurotransmitter Release Cycle", "Glutamate Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle", "Acetylcholine Neurotransmitter Release Cycle", "GABA synthesis, release, reuptake and degradation"], "O14815": ["Degradation of the extracellular matrix"], "O14818": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "O14827": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events", "Ras activation upon Ca2+ influx through NMDA receptor", "RAF/MAP kinase cascade"], "O14829": ["Inactivation, recovery and regulation of the phototransduction cascade"], "O14832": ["Alpha-oxidation of phytanate", "Peroxisomal protein import", "Peroxisomal protein import", "TYSND1 cleaves peroxisomal proteins"], "O14836": ["TNFs bind their physiological receptors"], "O14841": ["Glutathione synthesis and recycling", "Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD)"], "O14842": ["Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)", "G alpha (q) signalling events", "Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "Free fatty acid receptors"], "O14843": ["G alpha (q) signalling events", "Free fatty acid receptors"], "O14862": ["The AIM2 inflammasome", "The AIM2 inflammasome"], "O14874": ["Branched-chain amino acid catabolism"], "O14879": ["Interferon alpha/beta signaling"], "O14880": ["Glutathione conjugation", "Aflatoxin activation and detoxification"], "O14893": ["snRNP Assembly"], "O14896": ["Interferon gamma signaling", "Interferon alpha/beta signaling"], "O14904": ["TCF dependent signaling in response to WNT", "WNT ligand biogenesis and trafficking", "WNT ligand biogenesis and trafficking", "Class B/2 (Secretin family receptors)", "Negative regulation of TCF-dependent signaling by WNT ligand antagonists"], "O14905": ["WNT ligand biogenesis and trafficking", "WNT ligand biogenesis and trafficking", "Class B/2 (Secretin family receptors)"], "O14907": ["RHO GTPases Activate Rhotekin and Rhophilins"], "O14910": ["Dopamine Neurotransmitter Release Cycle", "Neurexins and neuroligins"], "O14920": ["Activation of NF-kappaB in B cells", "Activation of NF-kappaB in B cells", "ER-Phagosome pathway", "NOD1/2 Signaling Pathway", "TICAM1, RIP1-mediated IKK complex recruitment ", "RIP-mediated NFkB activation via ZBP1", "Downstream TCR signaling", "p75NTR recruits signalling complexes", "NF-kB is activated and signals survival", "FCERI mediated NF-kB activation", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "IKBKB deficiency causes SCID", "IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)", "IkBA variant leads to EDA-ID", "CLEC7A (Dectin-1) signaling", "MAP3K8 (TPL2)-dependent MAPK1/3 activation", "Interleukin-1 signaling", "TRAF6 mediated NF-kB activation", "NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10", "IRAK1 recruits IKK complex", "IKK complex recruitment mediated by RIP1", "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation"], "O14921": ["G alpha (q) signalling events", "G alpha (i) signalling events", "G alpha (i) signalling events"], "O14924": ["G alpha (i) signalling events", "G alpha (i) signalling events"], "O14925": ["Mitochondrial protein import", "Mitochondrial protein import"], "O14929": ["HATs acetylate histones"], "O14931": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "O14933": ["ISG15 antiviral mechanism", "DDX58/IFIH1-mediated induction of interferon-alpha/beta", "Termination of translesion DNA synthesis", "Negative regulators of DDX58/IFIH1 signaling", "Negative regulators of DDX58/IFIH1 signaling", "Amyloid fiber formation", "Antigen processing: Ubiquitination & Proteasome degradation"], "O14936": ["Dopamine Neurotransmitter Release Cycle", "Syndecan interactions", "Nephrin family interactions", "Neurexins and neuroligins", "Neurexins and neuroligins"], "O14939": ["Synthesis of PG", "Synthesis of PA", "Role of phospholipids in phagocytosis"], "O14944": ["Signaling by ERBB2", "Signaling by ERBB4", "SHC1 events in ERBB2 signaling", "SHC1 events in ERBB2 signaling", "PI3K events in ERBB4 signaling", "SHC1 events in ERBB4 signaling", "Nuclear signaling by ERBB4", "PIP3 activates AKT signaling", "Signaling by EGFR", "GRB2 events in EGFR signaling", "GAB1 signalosome", "SHC1 events in EGFR signaling", "EGFR downregulation", "GRB2 events in ERBB2 signaling", "PI3K events in ERBB2 signaling", "EGFR interacts with phospholipase C-gamma", "Constitutive Signaling by Aberrant PI3K in Cancer", "Inhibition of Signaling by Overexpressed EGFR", "RAF/MAP kinase cascade", "ERBB2 Regulates Cell Motility", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "ERBB2 Activates PTK6 Signaling", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "Downregulation of ERBB2 signaling"], "O14949": ["Respiratory electron transport"], "O14950": ["EPHA-mediated growth cone collapse", "Sema4D induced cell migration and growth-cone collapse", "Smooth Muscle Contraction", "RHO GTPases activate PKNs", "RHO GTPases activate CIT", "RHO GTPases Activate ROCKs", "RHO GTPases activate PAKs", "RHO GTPases activate PAKs"], "O14957": ["Respiratory electron transport"], "O14958": ["Stimuli-sensing channels", "Ion homeostasis"], "O14964": ["EGFR downregulation", "Lysosome Vesicle Biogenesis", "Ub-specific processing proteases", "Negative regulation of MET activity", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "InlB-mediated entry of Listeria monocytogenes into host cell", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "O14965": ["APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Regulation of PLK1 Activity at G2/M Transition", "SUMOylation of DNA replication proteins", "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "Regulation of TP53 Activity through Phosphorylation", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "AURKA Activation by TPX2", "Interaction between PHLDA1 and AURKA"], "O14966": ["RAB geranylgeranylation"], "O14974": ["Regulation of PLK1 Activity at G2/M Transition", "RHO GTPases activate PKNs", "RHO GTPases activate PKNs", "RHO GTPases activate CIT", "RHO GTPases Activate ROCKs", "RHO GTPases activate PAKs", "RHO GTPases activate PAKs"], "O14975": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of bile acids and bile salts via 24-hydroxycholesterol", "Alpha-oxidation of phytanate", "Neutrophil degranulation", "Peroxisomal protein import", "Peroxisomal protein import"], "O14976": ["Golgi Associated Vesicle Biogenesis", "Clathrin-mediated endocytosis"], "O14977": ["Regulation of ornithine decarboxylase (ODC)"], "O14978": ["Generic Transcription Pathway"], "O14979": ["Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "O14980": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Rev-mediated nuclear export of HIV RNA", "NEP/NS2 Interacts with the Cellular Export Machinery", "Downregulation of TGF-beta receptor signaling", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Deactivation of the beta-catenin transactivating complex", "HuR (ELAVL1) binds and stabilizes mRNA", "RHO GTPases Activate Formins", "MAPK6/MAPK4 signaling", "Mitotic Prometaphase", "Cyclin A/B1/B2 associated events during G2/M transition"], "O14983": ["Pre-NOTCH Processing in Golgi", "Reduction of cytosolic Ca++ levels", "Ion homeostasis", "Ion transport by P-type ATPases"], "O14986": ["Synthesis of PIPs at the plasma membrane", "WNT mediated activation of DVL", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "O14994": ["Serotonin Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle"], "O15013": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "O15020": ["MHC class II antigen presentation", "NCAM signaling for neurite out-growth", "NCAM signaling for neurite out-growth", "Interaction between L1 and Ankyrins", "Interaction between L1 and Ankyrins", "RAF/MAP kinase cascade", "COPI-mediated anterograde transport"], "O15027": ["COPII-mediated vesicle transport"], "O15033": ["Antigen processing: Ubiquitination & Proteasome degradation"], "O15041": ["Other semaphorin interactions"], "O15042": ["mRNA Splicing - Major Pathway"], "O15047": ["PKMTs methylate histone lysines", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"], "O15054": ["Oxidative Stress Induced Senescence", "HDMs demethylate histones"], "O15055": ["Circadian Clock"], "O15056": ["Synthesis of PIPs at the plasma membrane", "Clathrin-mediated endocytosis"], "O15066": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "MHC class II antigen presentation", "Intraflagellar transport", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins", "Kinesins"], "O15067": ["Purine ribonucleoside monophosphate biosynthesis"], "O15068": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "O15072": ["Collagen biosynthesis and modifying enzymes", "Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "O15078": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "Neutrophil degranulation", "AURKA Activation by TPX2"], "O15084": ["COPII-mediated vesicle transport"], "O15085": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events", "Sema4D induced cell migration and growth-cone collapse"], "O15091": ["tRNA processing in the mitochondrion", "tRNA modification in the mitochondrion", "rRNA processing in the mitochondrion"], "O15105": ["Signaling by BMP", "Downregulation of TGF-beta receptor signaling", "Downregulation of TGF-beta receptor signaling", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "UCH proteinases", "Ub-specific processing proteases"], "O15111": ["Activation of NF-kappaB in B cells", "Activation of NF-kappaB in B cells", "ER-Phagosome pathway", "NOD1/2 Signaling Pathway", "TICAM1, RIP1-mediated IKK complex recruitment ", "RIP-mediated NFkB activation via ZBP1", "AKT phosphorylates targets in the cytosol", "Downstream TCR signaling", "FCERI mediated NF-kB activation", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "IKBKB deficiency causes SCID", "IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)", "IkBA variant leads to EDA-ID", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Constitutive Signaling by AKT1 E17K in Cancer", "NIK-->noncanonical NF-kB signaling", "MAP3K8 (TPL2)-dependent MAPK1/3 activation", "Interleukin-1 signaling", "TRAF6 mediated NF-kB activation", "NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10", "IRAK1 recruits IKK complex", "IKK complex recruitment mediated by RIP1", "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation"], "O15116": ["mRNA decay by 5' to 3' exoribonuclease", "mRNA decay by 5' to 3' exoribonuclease"], "O15117": ["Generation of second messenger molecules", "Generation of second messenger molecules", "Signal regulatory protein family interactions"], "O15118": ["LDL clearance"], "O15120": ["Synthesis of PA", "Neutrophil degranulation"], "O15121": ["Sphingolipid de novo biosynthesis", "Neutrophil degranulation"], "O15123": ["Tie2 Signaling"], "O15126": ["Neutrophil degranulation"], "O15130": ["Orexin and neuropeptides FF and QRFP bind to their respective receptors", "G alpha (q) signalling events"], "O15131": ["ISG15 antiviral mechanism", "NS1 Mediated Effects on Host Pathways"], "O15143": ["Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "EPHB-mediated forward signaling", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs"], "O15144": ["Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "EPHB-mediated forward signaling", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs", "Clathrin-mediated endocytosis"], "O15145": ["Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "EPHB-mediated forward signaling", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs", "Clathrin-mediated endocytosis"], "O15146": ["ECM proteoglycans"], "O15151": ["Oxidative Stress Induced Senescence", "Oncogene Induced Senescence", "Ub-specific processing proteases", "Regulation of TP53 Activity through Phosphorylation", "Regulation of TP53 Degradation", "Regulation of TP53 Activity through Methylation", "Stabilization of p53"], "O15155": ["COPII-mediated vesicle transport", "COPI-mediated anterograde transport"], "O15160": ["Cytosolic sensors of pathogen-associated DNA ", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase III Chain Elongation", "RNA Polymerase I Transcription Termination", "RNA Polymerase III Transcription Termination", "RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "O15164": ["Signaling by cytosolic FGFR1 fusion mutants", "Signaling by FGFR1 in disease", "Signaling by BRAF and RAF fusions"], "O15169": ["Degradation of beta-catenin by the destruction complex", "Beta-catenin phosphorylation cascade", "TCF dependent signaling in response to WNT", "Degradation of AXIN", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Misspliced GSK3beta mutants stabilize beta-catenin", "S33 mutants of beta-catenin aren't phosphorylated", "S37 mutants of beta-catenin aren't phosphorylated", "S45 mutants of beta-catenin aren't phosphorylated", "T41 mutants of beta-catenin aren't phosphorylated", "APC truncation mutants have impaired AXIN binding", "AXIN missense mutants destabilize the destruction complex", "Truncations of AMER1 destabilize the destruction complex", "Ub-specific processing proteases", "RUNX1 regulates estrogen receptor mediated transcription", "RUNX1 regulates transcription of genes involved in WNT signaling", "Estrogen-dependent gene expression"], "O15181": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "O15197": ["EPH-Ephrin signaling", "EPH-Ephrin signaling", "EPHB-mediated forward signaling", "EPHB-mediated forward signaling", "Ephrin signaling", "Ephrin signaling", "EPH-ephrin mediated repulsion of cells"], "O15198": ["Signaling by BMP"], "O15205": ["Neddylation"], "O15212": ["Prefoldin mediated transfer of substrate to CCT/TriC"], "O15213": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "O15217": ["Glutathione conjugation"], "O15228": ["Synthesis of PA", "Plasmalogen biosynthesis", "Peroxisomal protein import", "Peroxisomal protein import"], "O15229": ["Tryptophan catabolism"], "O15230": ["Degradation of the extracellular matrix", "Laminin interactions", "Laminin interactions", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "Interleukin-4 and Interleukin-13 signaling", "MET activates PTK2 signaling"], "O15232": ["ECM proteoglycans", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "O15234": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "O15235": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "O15239": ["Respiratory electron transport", "Complex I biogenesis"], "O15240": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "O15244": ["Neurotransmitter clearance", "Norepinephrine Neurotransmitter Release Cycle", "Abacavir transmembrane transport", "Na+/Cl- dependent neurotransmitter transporters", "Organic cation transport"], "O15245": ["Neurotransmitter clearance", "Norepinephrine Neurotransmitter Release Cycle", "Abacavir transmembrane transport", "Na+/Cl- dependent neurotransmitter transporters", "Organic cation transport"], "O15247": ["Stimuli-sensing channels", "Ion homeostasis"], "O15254": ["Beta-oxidation of pristanoyl-CoA", "Peroxisomal protein import", "Peroxisomal protein import"], "O15259": ["Anchoring of the basal body to the plasma membrane"], "O15260": ["Neutrophil degranulation", "COPI-dependent Golgi-to-ER retrograde traffic"], "O15263": ["Beta defensins", "Defensins"], "O15264": ["NOD1/2 Signaling Pathway", "p38MAPK events", "DSCAM interactions", "VEGFA-VEGFR2 Pathway"], "O15265": ["HATs acetylate histones", "Ub-specific processing proteases"], "O15269": ["Sphingolipid de novo biosynthesis"], "O15270": ["Sphingolipid de novo biosynthesis"], "O15273": ["Striated Muscle Contraction"], "O15287": ["Fanconi Anemia Pathway"], "O15294": ["HATs acetylate histones", "UCH proteinases"], "O15296": ["Synthesis of 15-eicosatetraenoic acid derivatives"], "O15297": ["Transcriptional regulation by RUNX2"], "O15303": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "O15305": ["Defective PMM2 causes PMM2-CDG (CDG-1a)", "Synthesis of GDP-mannose"], "O15315": ["HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange", "Presynaptic phase of homologous DNA pairing and strand exchange", "Factors involved in megakaryocyte development and platelet production"], "O15318": ["Cytosolic sensors of pathogen-associated DNA ", "RNA Polymerase III Chain Elongation", "RNA Polymerase III Transcription Termination", "RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "O15320": ["Cargo concentration in the ER"], "O15327": ["Synthesis of PIPs at the plasma membrane", "Synthesis of PIPs at the early endosome membrane", "Synthesis of IP2, IP, and Ins in the cytosol"], "O15342": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "O15344": ["Interferon gamma signaling"], "O15350": ["Activation of PUMA and translocation to mitochondria", "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "TP53 Regulates Transcription of Caspase Activators and Caspases", "TP53 Regulates Transcription of Death Receptors and Ligands", "Regulation of TP53 Activity through Association with Co-factors", "RUNX1 regulates transcription of genes involved in differentiation of HSCs"], "O15354": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "O15357": ["Synthesis of PIPs at the plasma membrane", "Synthesis of IP3 and IP4 in the cytosol", "Interleukin receptor SHC signaling"], "O15360": ["Fanconi Anemia Pathway"], "O15371": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "O15372": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "O15379": ["NR1D1 (REV-ERBA) represses gene expression", "p75NTR negatively regulates cell cycle via SC1", "PPARA activates gene expression", "NOTCH1 Intracellular Domain Regulates Transcription", "Transcriptional activation of mitochondrial biogenesis", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "HDACs deacetylate histones", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation", "Association of TriC/CCT with target proteins during biosynthesis", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)", "Circadian Clock", "Circadian Clock", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "RUNX2 regulates osteoblast differentiation", "Regulation of PTEN gene transcription", "Loss of MECP2 binding ability to the NCoR/SMRT complex", "Regulation of MECP2 expression and activity"], "O15382": ["Branched-chain amino acid catabolism"], "O15389": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation"], "O15392": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA replication proteins", "RHO GTPases Activate Formins", "Interleukin-4 and Interleukin-13 signaling", "TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "Mitotic Prometaphase", "Neddylation"], "O15397": ["Transcriptional regulation by small RNAs"], "O15399": ["Unblocking of NMDA receptors, glutamate binding and activation", "Unblocking of NMDA receptors, glutamate binding and activation", "Ras activation upon Ca2+ influx through NMDA receptor", "RAF/MAP kinase cascade", "Neurexins and neuroligins", "Synaptic adhesion-like molecules", "Negative regulation of NMDA receptor-mediated neuronal transmission", "Long-term potentiation"], "O15427": ["Basigin interactions", "Proton-coupled monocarboxylate transport", "Pyruvate metabolism"], "O15431": ["Metal ion SLC transporters"], "O15438": ["Recycling of bile acids and salts", "ABC-family proteins mediated transport"], "O15439": ["Platelet degranulation ", "ABC-family proteins mediated transport"], "O15440": ["Hyaluronan biosynthesis and export", "ABC-family proteins mediated transport"], "O15444": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "O15446": ["NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase I Transcription Termination"], "O15455": ["Trafficking and processing of endosomal TLR", "Toll Like Receptor 3 (TLR3) Cascade", "TICAM1, RIP1-mediated IKK complex recruitment ", "RIP-mediated NFkB activation via ZBP1", "TLR3 deficiency - HSE", "UNC93B1 deficiency - HSE", "TICAM1 deficiency - HSE", "TRAF3 deficiency - HSE", "TLR3-mediated TICAM1-dependent programmed cell death", "TICAM1-dependent activation of IRF3/IRF7", "TICAM1,TRAF6-dependent induction of TAK1 complex"], "O15457": ["Meiotic recombination"], "O15460": ["Collagen biosynthesis and modifying enzymes"], "O15466": ["Sialic acid metabolism"], "O15467": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "O15484": ["Degradation of the extracellular matrix"], "O15488": ["Glycogen synthesis", "Glycogen storage disease type 0 (liver GYS2)", "Glycogen storage disease type IV (GBE1)", "Glycogen breakdown (glycogenolysis)"], "O15492": ["G alpha (q) signalling events", "G alpha (i) signalling events", "G alpha (i) signalling events", "G alpha (z) signalling events"], "O15496": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PS", "Acyl chain remodelling of PE", "Acyl chain remodelling of PI", "Acyl chain remodelling of PG", "Synthesis of PA"], "O15498": ["COPII-mediated vesicle transport", "COPI-mediated anterograde transport", "Intra-Golgi traffic"], "O15503": ["Regulation of cholesterol biosynthesis by SREBP (SREBF)"], "O15504": ["ISG15 antiviral mechanism", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "tRNA processing in the nucleus"], "O15511": ["Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "EPHB-mediated forward signaling", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs", "Neutrophil degranulation", "Clathrin-mediated endocytosis"], "O15514": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Abortive elongation of HIV-1 transcript in the absence of Tat", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "Viral Messenger RNA Synthesis", "MicroRNA (miRNA) biogenesis", "Transcriptional regulation of pluripotent stem cells", "Transcriptional regulation by small RNAs", "PIWI-interacting RNA (piRNA) biogenesis", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE", "Signaling by FGFR2 IIIa TM", "Estrogen-dependent gene expression"], "O15516": ["BMAL1:CLOCK,NPAS2 activates circadian gene expression", "BMAL1:CLOCK,NPAS2 activates circadian gene expression", "PPARA activates gene expression", "HATs acetylate histones", "Circadian Clock"], "O15519": ["TRAIL signaling"], "O15519-1": ["Regulation by c-FLIP", "RIPK1-mediated regulated necrosis", "CASP8 activity is inhibited"], "O15519-2": ["RIPK1-mediated regulated necrosis", "CASP8 activity is inhibited", "Dimerization of procaspase-8"], "O15520": ["PI3K Cascade", "PIP3 activates AKT signaling", "FGFR1b ligand binding and activation", "FGFR2b ligand binding and activation", "Activated point mutants of FGFR2", "Regulation of gene expression in early pancreatic precursor cells", "Constitutive Signaling by Aberrant PI3K in Cancer", "Phospholipase C-mediated cascade: FGFR1", "Phospholipase C-mediated cascade; FGFR2", "Downstream signaling of activated FGFR1", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Signaling by FGFR2 in disease", "FGFRL1 modulation of FGFR1 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "O15524": ["Interleukin-7 signaling", "Regulation of KIT signaling", "MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "Interleukin-4 and Interleukin-13 signaling", "Interferon gamma signaling", "Regulation of IFNG signaling", "Interferon alpha/beta signaling", "Regulation of IFNA signaling", "Growth hormone receptor signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "O15525": ["Factors involved in megakaryocyte development and platelet production", "Factors involved in megakaryocyte development and platelet production"], "O15527": ["Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "Cleavage of the damaged pyrimidine ", "Recognition and association of DNA glycosylase with site containing an affected purine", "Cleavage of the damaged purine", "Displacement of DNA glycosylase by APEX1", "APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway"], "O15528": ["Vitamin D (calciferol) metabolism", "Vitamins", "Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A)"], "O15530": ["GPVI-mediated activation cascade", "GPVI-mediated activation cascade", "PIP3 activates AKT signaling", "Activation of AKT2", "Downstream TCR signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated NF-kB activation", "Integrin alphaIIb beta3 signaling", "CD28 dependent PI3K/Akt signaling", "G beta:gamma signalling through PI3Kgamma", "RSK activation", "VEGFR2 mediated vascular permeability", "VEGFR2 mediated cell proliferation", "CLEC7A (Dectin-1) signaling", "RHO GTPases activate PKNs", "Constitutive Signaling by AKT1 E17K in Cancer", "Regulation of TP53 Degradation"], "O15533": ["ER-Phagosome pathway", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "O15534": ["Circadian Clock"], "O15539": ["G alpha (q) signalling events", "G alpha (i) signalling events", "G alpha (i) signalling events"], "O15540": ["Triglyceride catabolism", "NOTCH3 Intracellular Domain Regulates Transcription"], "O15547": ["Elevation of cytosolic Ca2+ levels", "Platelet homeostasis"], "O15550": ["HDMs demethylate histones", "Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "O15551": ["Tight junction interactions"], "O15552": ["G alpha (q) signalling events", "Free fatty acid receptors"], "O15553": ["The NLRP3 inflammasome"], "O15554": ["Ca2+ activated K+ channels"], "O43143": ["mRNA Splicing - Major Pathway"], "O43148": ["RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "mRNA Capping", "RNA Pol II CTD phosphorylation and interaction with CE"], "O43151": ["TET1,2,3 and TDG demethylate DNA"], "O43155": ["Downstream signaling of activated FGFR1"], "O43157": ["G alpha (12/13) signalling events", "Sema4D mediated inhibition of cell attachment and migration", "Sema4D induced cell migration and growth-cone collapse"], "O43159": ["SIRT1 negatively regulates rRNA expression"], "O43164": ["Antigen processing: Ubiquitination & Proteasome degradation"], "O43166": ["Neurexins and neuroligins"], "O43169": ["Phase I - Functionalization of compounds"], "O43172": ["mRNA Splicing - Major Pathway"], "O43173": ["Sialic acid metabolism", "N-Glycan antennae elongation"], "O43174": ["Vitamins", "RA biosynthesis pathway"], "O43175": ["Serine biosynthesis"], "O43181": ["Respiratory electron transport", "Complex I biogenesis"], "O43182": ["Rho GTPase cycle"], "O43184": ["Signaling by EGFR", "Invadopodia formation"], "O43187": ["MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "NOD1/2 Signaling Pathway", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "activated TAK1 mediates p38 MAPK activation", "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "Interleukin-1 signaling", "IRAK2 mediated activation of TAK1 complex", "TRAF6-mediated induction of TAK1 complex within TLR4 complex", "TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "MyD88 dependent cascade initiated on endosome", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "MyD88 cascade initiated on plasma membrane"], "O43189": ["PRC2 methylates histones and DNA"], "O43193": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "O43194": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (q) signalling events", "G alpha (s) signalling events"], "O43196": ["Meiotic recombination"], "O43236-6": ["Release of apoptotic factors from the mitochondria", "SMAC, XIAP-regulated apoptotic response"], "O43237": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase"], "O43242": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "Neutrophil degranulation", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "O43251": ["FGFR2 alternative splicing"], "O43252": ["Transport and synthesis of PAPS", "Metabolism of ingested H2SeO4 and H2SeO3 into H2Se", "Signaling by BRAF and RAF fusions"], "O43255": ["Netrin-1 signaling", "Ub-specific processing proteases", "Amyloid fiber formation", "Antigen processing: Ubiquitination & Proteasome degradation"], "O43264": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "COPI-dependent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase"], "O43272": ["Proline catabolism"], "O43278": ["MET Receptor Activation", "Signaling by MST1"], "O43280": ["Digestion of dietary carbohydrate"], "O43286": ["Keratan sulfate biosynthesis", "O-linked glycosylation of mucins", "N-Glycan antennae elongation"], "O43290": ["mRNA Splicing - Major Pathway"], "O43291": ["MET Receptor Activation", "Signaling by MST1"], "O43292": ["Attachment of GPI anchor to uPAR"], "O43293": ["Caspase activation via Dependence Receptors in the absence of ligand"], "O43295": ["Rho GTPase cycle", "Inactivation of CDC42 and RAC1"], "O43296": ["Generic Transcription Pathway"], "O43300": ["Neurexins and neuroligins"], "O43301": ["Regulation of HSF1-mediated heat shock response"], "O43303": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "Ub-specific processing proteases", "AURKA Activation by TPX2"], "O43306": ["Glucagon signaling in metabolic regulation", "PKA activation", "PKA activation in glucagon signalling", "Adenylate cyclase activating pathway", "Adenylate cyclase inhibitory pathway", "Adenylate cyclase inhibitory pathway", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Adrenaline,noradrenaline inhibits insulin secretion", "G alpha (s) signalling events", "G alpha (s) signalling events", "G alpha (i) signalling events", "G alpha (z) signalling events", "G alpha (z) signalling events", "Vasopressin regulates renal water homeostasis via Aquaporins", "Hedgehog 'off' state"], "O43307": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events", "GABA A receptor activation", "GABA receptor activation"], "O43314": ["Synthesis of pyrophosphates in the cytosol"], "O43315": ["Transport of glycerol from adipocytes to the liver by Aquaporins", "Passive transport by Aquaporins"], "O43316": ["Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells"], "O43318": ["Activation of NF-kappaB in B cells", "NOD1/2 Signaling Pathway", "Downstream TCR signaling", "FCERI mediated NF-kB activation", "Ca2+ pathway", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "activated TAK1 mediates p38 MAPK activation", "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "TNFR1-induced NFkappaB signaling pathway", "CLEC7A (Dectin-1) signaling", "Ub-specific processing proteases", "TICAM1,TRAF6-dependent induction of TAK1 complex", "Interleukin-1 signaling", "IRAK2 mediated activation of TAK1 complex", "TRAF6-mediated induction of TAK1 complex within TLR4 complex", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"], "O43320": ["PI3K Cascade", "PIP3 activates AKT signaling", "Signaling by activated point mutants of FGFR3", "FGFR4 ligand binding and activation", "FGFR3c ligand binding and activation", "FGFR2c ligand binding and activation", "FGFR3 mutant receptor activation", "Activated point mutants of FGFR2", "Constitutive Signaling by Aberrant PI3K in Cancer", "Phospholipase C-mediated cascade; FGFR2", "Phospholipase C-mediated cascade; FGFR3", "Phospholipase C-mediated cascade; FGFR4", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "PI-3K cascade:FGFR3", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "PI-3K cascade:FGFR4", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "Signaling by FGFR2 in disease", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Signaling by FGFR3 point mutants in cancer"], "O43323": ["Class B/2 (Secretin family receptors)", "Hedgehog ligand biogenesis", "Release of Hh-Np from the secreting cell", "Release of Hh-Np from the secreting cell", "Ligand-receptor interactions", "Ligand-receptor interactions", "Hedgehog 'on' state", "Activation of SMO", "HHAT G278V abrogates palmitoylation of Hh-Np"], "O43324": ["SeMet incorporation into proteins", "Cytosolic tRNA aminoacylation"], "O43345": ["Generic Transcription Pathway"], "O43347": ["Regulation of expression of SLITs and ROBOs"], "O43353": ["NOD1/2 Signaling Pathway", "NOD1/2 Signaling Pathway", "Downstream TCR signaling", "p75NTR recruits signalling complexes", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "activated TAK1 mediates p38 MAPK activation", "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "Ovarian tumor domain proteases", "Interleukin-1 signaling"], "O43361": ["Generic Transcription Pathway"], "O43364": ["Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Regulation of expression of SLITs and ROBOs"], "O43365": ["Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "O43374": ["Regulation of RAS by GAPs", "Signaling by RAS mutants"], "O43390": ["mRNA Splicing - Major Pathway", "Processing of Capped Intron-Containing Pre-mRNA"], "O43395": ["mRNA Splicing - Major Pathway"], "O43426": ["Synthesis of PIPs at the plasma membrane", "Synthesis of IP2, IP, and Ins in the cytosol", "Synthesis of IP3 and IP4 in the cytosol", "Clathrin-mediated endocytosis"], "O43432": ["ISG15 antiviral mechanism"], "O43447": ["mRNA Splicing - Major Pathway"], "O43448": ["Voltage gated Potassium channels"], "O43451": ["Digestion of dietary carbohydrate", "Neutrophil degranulation"], "O43462": ["Regulation of cholesterol biosynthesis by SREBP (SREBF)", "ATF6 (ATF6-alpha) activates chaperones", "CREB3 factors activate genes", "CREB3 factors activate genes", "Assembly of active LPL and LIPC lipase complexes"], "O43463": ["PKMTs methylate histone lysines", "SIRT1 negatively regulates rRNA expression"], "O43474": ["Transcriptional regulation of white adipocyte differentiation", "Synthesis, secretion, and deacylation of Ghrelin", "Transcriptional regulation of pluripotent stem cells", "FOXO-mediated transcription of cell cycle genes"], "O43482": ["Deposition of new CENPA-containing nucleosomes at the centromere"], "O43488": ["Aflatoxin activation and detoxification"], "O43491": ["Neurexins and neuroligins"], "O43493": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Golgi Associated Vesicle Biogenesis", "Retrograde transport at the Trans-Golgi-Network", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "Post-translational protein phosphorylation"], "O43497": ["NCAM1 interactions"], "O43502": ["HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange", "Presynaptic phase of homologous DNA pairing and strand exchange", "Meiotic recombination", "Factors involved in megakaryocyte development and platelet production"], "O43504": ["Macroautophagy", "mTOR signalling", "mTORC1-mediated signalling", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Regulation of PTEN gene transcription"], "O43505": ["Keratan sulfate biosynthesis", "O-linked glycosylation"], "O43506": ["Interaction With The Zona Pellucida"], "O43508": ["TNFR2 non-canonical NF-kB pathway", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "O43511": ["Multifunctional anion exchangers", "Defective SLC26A4 causes Pendred syndrome (PDS)"], "O43513": ["PPARA activates gene expression", "Generic Transcription Pathway", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "O43516": ["Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs"], "O43520": ["Ion transport by P-type ATPases"], "O43521": ["Activation of BIM and translocation to mitochondria ", "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "NRAGE signals death through JNK", "Signaling by BRAF and RAF fusions", "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "RUNX3 regulates BCL2L11 (BIM) transcription", "FOXO-mediated transcription of cell death genes"], "O43524": ["Signaling by NODAL", "AKT phosphorylates targets in the nucleus", "Constitutive Signaling by AKT1 E17K in Cancer", "MAPK6/MAPK4 signaling", "Interleukin-4 and Interleukin-13 signaling", "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "RUNX3 regulates BCL2L11 (BIM) transcription", "Regulation of localization of FOXO transcription factors", "FOXO-mediated transcription of cell death genes", "FOXO-mediated transcription of cell death genes", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "Regulation of FOXO transcriptional activity by acetylation", "FOXO-mediated transcription of cell cycle genes", "FOXO-mediated transcription of cell cycle genes"], "O43525": ["Voltage gated Potassium channels", "Interaction between L1 and Ankyrins"], "O43526": ["Voltage gated Potassium channels", "Interaction between L1 and Ankyrins"], "O43529": ["Reactions specific to the complex N-glycan synthesis pathway"], "O43541": ["Signaling by BMP", "RUNX2 regulates bone development"], "O43542": ["HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange"], "O43543": ["HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange", "Presynaptic phase of homologous DNA pairing and strand exchange"], "O43548": ["Formation of the cornified envelope"], "O43555": ["Hormone ligand-binding receptors", "G alpha (q) signalling events"], "O43557": ["TNFR2 non-canonical NF-kB pathway", "TNFs bind their physiological receptors", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "O43559": ["FRS-mediated FGFR1 signaling", "FRS-mediated FGFR2 signaling", "FRS-mediated FGFR3 signaling", "FRS-mediated FGFR4 signaling", "RAF/MAP kinase cascade", "Activated NTRK2 signals through FRS2 and FRS3"], "O43561": ["GPVI-mediated activation cascade", "Generation of second messenger molecules"], "O43561-2": ["DAP12 signaling", "Fc epsilon receptor (FCERI) signaling", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "RAF/MAP kinase cascade"], "O43566": ["G alpha (i) signalling events", "G alpha (i) signalling events"], "O43570": ["Reversible hydration of carbon dioxide"], "O43572": ["Factors involved in megakaryocyte development and platelet production"], "O43581": ["Neurexins and neuroligins"], "O43586": ["The NLRP3 inflammasome"], "O43592": ["tRNA processing in the nucleus"], "O43597": ["Spry regulation of FGF signaling", "EGFR downregulation"], "O43598": ["Purine catabolism"], "O43602": ["Neurofascin interactions"], "O43603": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "O43609": ["EGFR downregulation"], "O43612": ["Orexin and neuropeptides FF and QRFP bind to their respective receptors", "G alpha (q) signalling events"], "O43613": ["Orexin and neuropeptides FF and QRFP bind to their respective receptors", "G alpha (q) signalling events"], "O43614": ["Orexin and neuropeptides FF and QRFP bind to their respective receptors", "G alpha (q) signalling events"], "O43615": ["Mitochondrial protein import"], "O43617": ["COPII-mediated vesicle transport", "RAB GEFs exchange GTP for GDP on RABs"], "O43623": ["Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription"], "O43633": ["Budding and maturation of HIV virion", "Macroautophagy", "Lysosome Vesicle Biogenesis", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "O43639": ["Downstream signal transduction", "Nephrin family interactions", "Ephrin signaling", "Activation of RAC1", "VEGFA-VEGFR2 Pathway", "Regulation of cortical dendrite branching"], "O43653": ["Post-translational modification: synthesis of GPI-anchored proteins"], "O43660": ["mRNA Splicing - Major Pathway"], "O43663": ["RHO GTPases activate CIT"], "O43665": ["G alpha (i) signalling events", "G alpha (i) signalling events"], "O43674": ["Respiratory electron transport", "Complex I biogenesis"], "O43676": ["Respiratory electron transport", "Complex I biogenesis"], "O43677": ["Respiratory electron transport", "Complex I biogenesis"], "O43678": ["Respiratory electron transport", "Complex I biogenesis"], "O43681": ["XBP1(S) activates chaperone genes"], "O43683": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "O43684": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "APC/C:Cdc20 mediated degradation of mitotic proteins", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "O43688": ["Sphingolipid de novo biosynthesis"], "O43699": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "O43704": ["Cytosolic sulfonation of small molecules"], "O43707": ["Platelet degranulation ", "Nephrin family interactions"], "O43708": ["Glutathione conjugation", "Regulation of pyruvate dehydrogenase (PDH) complex", "Phenylalanine and tyrosine catabolism"], "O43709": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "O43715": ["TP53 Regulates Transcription of Genes Involved in Cytochrome C Release"], "O43731": ["XBP1(S) activates chaperone genes", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "O43739": ["Intra-Golgi traffic"], "O43741": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Macroautophagy", "AMPK inhibits chREBP transcriptional activation activity", "AMPK inhibits chREBP transcriptional activation activity", "Import of palmitoyl-CoA into the mitochondrial matrix", "Activation of PPARGC1A (PGC-1alpha) by phosphorylation", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Regulation of TP53 Activity through Phosphorylation", "Activation of AMPK downstream of NMDARs"], "O43747": ["Nef mediated downregulation of MHC class I complex cell surface expression", "MHC class II antigen presentation", "Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis"], "O43749": ["Olfactory Signaling Pathway"], "O43752": ["Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network"], "O43759": ["Neutrophil degranulation"], "O43766": ["Glyoxylate metabolism and glycine degradation"], "O43768": ["MASTL Facilitates Mitotic Progression", "MASTL Facilitates Mitotic Progression"], "O43772": ["Import of palmitoyl-CoA into the mitochondrial matrix"], "O43776": ["Cytosolic tRNA aminoacylation"], "O43790": ["Keratinization", "Formation of the cornified envelope"], "O43791": ["Hedgehog 'on' state"], "O43805": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "O43808": ["Alpha-oxidation of phytanate"], "O43809": ["Cleavage of Growing Transcript in the Termination Region ", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "O43818": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "O43819": ["TP53 Regulates Metabolic Genes", "Respiratory electron transport"], "O43820": ["CS/DS degradation", "Hyaluronan uptake and degradation"], "O43826": ["Glycogen storage disease type Ib (SLC37A4)", "Gluconeogenesis"], "O43837": ["Citric acid cycle (TCA cycle)"], "O43852": ["Platelet degranulation ", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "O43861": ["Ion transport by P-type ATPases"], "O43865": ["PLC beta mediated events", "DAG and IP3 signaling", "Role of phospholipids in phagocytosis", "FCERI mediated Ca+2 mobilization", "Regulation of insulin secretion", "VEGFR2 mediated cell proliferation", "Ion homeostasis", "Ion homeostasis", "CLEC7A (Dectin-1) induces NFAT activation", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "O43868": ["Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"], "O43869": ["Olfactory Signaling Pathway"], "O43889": ["CREB3 factors activate genes", "CREB3 factors activate genes"], "O43895": ["Post-translational modification: synthesis of GPI-anchored proteins"], "O43896": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "O43897": ["Degradation of the extracellular matrix", "Collagen biosynthesis and modifying enzymes", "Anchoring fibril formation", "Crosslinking of collagen fibrils"], "O43903": ["Caspase-mediated cleavage of cytoskeletal proteins"], "O43909": ["XBP1(S) activates chaperone genes"], "O43913": ["E2F-enabled inhibition of pre-replication complex formation", "Activation of ATR in response to replication stress", "Assembly of the ORC complex at the origin of replication", "CDC6 association with the ORC:origin complex", "CDT1 association with the CDC6:ORC:origin complex", "Assembly of the pre-replicative complex", "Orc1 removal from chromatin", "Activation of the pre-replicative complex"], "O43914": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "DAP12 interactions", "DAP12 interactions", "DAP12 signaling", "DAP12 signaling", "Signal regulatory protein family interactions", "Other semaphorin interactions", "Neutrophil degranulation"], "O43915": ["Platelet degranulation ", "VEGF ligand-receptor interactions", "VEGF binds to VEGFR leading to receptor dimerization"], "O43916": ["Keratan sulfate biosynthesis"], "O43920": ["Respiratory electron transport", "Complex I biogenesis"], "O43921": ["EPH-Ephrin signaling", "EPH-Ephrin signaling", "EPHA-mediated growth cone collapse", "EPHA-mediated growth cone collapse", "EPH-ephrin mediated repulsion of cells", "EPH-ephrin mediated repulsion of cells"], "O43924": ["ARL13B-mediated ciliary trafficking of INPP5E"], "O43927": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "O43929": ["E2F-enabled inhibition of pre-replication complex formation", "Activation of ATR in response to replication stress", "Assembly of the ORC complex at the origin of replication", "CDC6 association with the ORC:origin complex", "CDT1 association with the CDC6:ORC:origin complex", "Assembly of the pre-replicative complex", "Orc1 removal from chromatin", "Activation of the pre-replicative complex"], "O43933": ["Peroxisomal protein import", "Peroxisomal protein import"], "O53533": ["Tolerance by Mtb to nitric oxide produced by macrophages"], "O60216": ["Meiotic synapsis", "Separation of Sister Chromatids", "Establishment of Sister Chromatid Cohesion", "Cohesin Loading onto Chromatin", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA damage response and repair proteins", "Estrogen-dependent gene expression"], "O60218": ["Retinoid metabolism and transport"], "O60220": ["Mitochondrial protein import"], "O60229": ["NRAGE signals death through JNK", "Rho GTPase cycle", "EPHB-mediated forward signaling", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "MAPK6/MAPK4 signaling"], "O60231": ["mRNA Splicing - Major Pathway"], "O60234": ["Neutrophil degranulation"], "O60237": ["RHO GTPases activate PKNs", "RHO GTPases activate PKNs", "RHO GTPases activate CIT", "RHO GTPases Activate ROCKs", "RHO GTPases activate PAKs", "RHO GTPases activate PAKs"], "O60237-4": ["Regulation of PLK1 Activity at G2/M Transition"], "O60238": ["TP53 Regulates Transcription of Genes Involved in Cytochrome C Release"], "O60240": ["Triglyceride catabolism", "Transcriptional regulation of white adipocyte differentiation"], "O60243": ["HS-GAG biosynthesis"], "O60244": ["PPARA activates gene expression", "Generic Transcription Pathway", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "O60245": ["Platelet degranulation "], "O60258-1": ["PI3K Cascade", "PIP3 activates AKT signaling", "Signaling by activated point mutants of FGFR1", "Signaling by activated point mutants of FGFR3", "FGFR4 ligand binding and activation", "FGFR3b ligand binding and activation", "FGFR3c ligand binding and activation", "FGFR1c ligand binding and activation", "FGFR2c ligand binding and activation", "FGFR3 mutant receptor activation", "Activated point mutants of FGFR2", "Constitutive Signaling by Aberrant PI3K in Cancer", "Phospholipase C-mediated cascade: FGFR1", "Phospholipase C-mediated cascade; FGFR2", "Phospholipase C-mediated cascade; FGFR3", "Phospholipase C-mediated cascade; FGFR4", "Downstream signaling of activated FGFR1", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "PI-3K cascade:FGFR3", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "PI-3K cascade:FGFR4", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "Signaling by FGFR2 in disease", "Signaling by FGFR1 in disease", "FGFRL1 modulation of FGFR1 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Signaling by FGFR3 point mutants in cancer"], "O60259": ["Formation of the cornified envelope"], "O60260": ["Pink/Parkin Mediated Mitophagy", "Josephin domain DUBs", "Amyloid fiber formation", "Antigen processing: Ubiquitination & Proteasome degradation"], "O60262": ["Activation of G protein gated Potassium channels", "Glucagon signaling in metabolic regulation", "G-protein activation", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42", "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "O60264": ["NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Deposition of new CENPA-containing nucleosomes at the centromere"], "O60266": ["Glucagon signaling in metabolic regulation", "PKA activation", "PKA activation in glucagon signalling", "Adenylate cyclase activating pathway", "Adenylate cyclase inhibitory pathway", "Adenylate cyclase inhibitory pathway", "G alpha (s) signalling events", "G alpha (s) signalling events", "G alpha (i) signalling events", "G alpha (z) signalling events", "G alpha (z) signalling events", "Vasopressin regulates renal water homeostasis via Aquaporins", "Hedgehog 'off' state"], "O60271": ["CDO in myogenesis", "CDO in myogenesis"], "O60282": ["Insulin processing"], "O60285": ["Regulation of TP53 Activity through Phosphorylation"], "O60291": ["Antigen processing: Ubiquitination & Proteasome degradation"], "O60294": ["Synthesis of wybutosine at G37 of tRNA(Phe)", "Synthesis of wybutosine at G37 of tRNA(Phe)"], "O60304": ["Generic Transcription Pathway"], "O60306": ["Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "mRNA Splicing - Major Pathway"], "O60312": ["Ion transport by P-type ATPases"], "O60313": ["Regulation of Apoptosis"], "O60331": ["Synthesis of PIPs at the plasma membrane", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Clathrin-mediated endocytosis"], "O60333": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "O60337": ["ER Quality Control Compartment (ERQC)"], "O60341": ["HDACs deacetylate histones", "HDMs demethylate histones", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Regulation of PTEN gene transcription", "Estrogen-dependent gene expression", "Factors involved in megakaryocyte development and platelet production"], "O60343": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane"], "O60346": ["Negative regulation of the PI3K/AKT network"], "O60353": ["Class B/2 (Secretin family receptors)", "Ca2+ pathway", "Ca2+ pathway", "PCP/CE pathway", "PCP/CE pathway", "Regulation of FZD by ubiquitination", "RNF mutants show enhanced WNT signaling and proliferation"], "O60359": ["Trafficking of AMPA receptors", "Phase 0 - rapid depolarisation", "Phase 2 - plateau phase", "LGI-ADAM interactions"], "O60361": ["Interconversion of nucleotide di- and triphosphates"], "O60403": ["Olfactory Signaling Pathway"], "O60404": ["Olfactory Signaling Pathway"], "O60412": ["Olfactory Signaling Pathway"], "O60422": ["Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "Regulation of gene expression in early pancreatic precursor cells"], "O60423": ["Ion transport by P-type ATPases"], "O60427": ["PPARA activates gene expression", "Linoleic acid (LA) metabolism", "alpha-linolenic acid (ALA) metabolism"], "O60431": ["Olfactory Signaling Pathway"], "O60437": ["Formation of the cornified envelope", "Butyrophilin (BTN) family interactions"], "O60462": ["Neurophilin interactions with VEGF and VEGFR", "NrCAM interactions"], "O60469": ["DSCAM interactions", "DSCAM interactions"], "O60476": ["Intra-Golgi traffic", "Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2"], "O60481": ["POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation", "Transcriptional regulation of pluripotent stem cells"], "O60486": ["Other semaphorin interactions"], "O60488": ["Synthesis of very long-chain fatty acyl-CoAs"], "O60493": ["WNT ligand biogenesis and trafficking", "Ub-specific processing proteases"], "O60494": ["Cobalamin (Cbl, vitamin B12) transport and metabolism", "Vitamin D (calciferol) metabolism", "Defective AMN causes hereditary megaloblastic anemia 1", "Defective CUBN causes hereditary megaloblastic anemia 1", "HDL clearance"], "O60496": ["Tie2 Signaling", "RET signaling"], "O60499": ["Retrograde transport at the Trans-Golgi-Network"], "O60500": ["Nephrin family interactions", "Nephrin family interactions"], "O60503": ["Glucagon signaling in metabolic regulation", "PKA activation", "PKA activation in glucagon signalling", "Adenylate cyclase activating pathway", "Adenylate cyclase inhibitory pathway", "Adenylate cyclase inhibitory pathway", "G alpha (s) signalling events", "G alpha (s) signalling events", "G alpha (i) signalling events", "G alpha (z) signalling events", "G alpha (z) signalling events", "Vasopressin regulates renal water homeostasis via Aquaporins", "Hedgehog 'off' state"], "O60504": ["Smooth Muscle Contraction"], "O60507": ["Cytosolic sulfonation of small molecules"], "O60508": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing"], "O60512": ["Keratan sulfate biosynthesis", "N-Glycan antennae elongation"], "O60513": ["Keratan sulfate biosynthesis", "N-Glycan antennae elongation"], "O60522": ["PIWI-interacting RNA (piRNA) biogenesis"], "O60542": ["NCAM1 interactions", "RAF/MAP kinase cascade", "RET signaling"], "O60543": ["Lipid particle organization"], "O60547": ["GDP-fucose biosynthesis"], "O60551": ["Membrane binding and targetting of GAG proteins", "Inactivation, recovery and regulation of the phototransduction cascade"], "O60563": ["Formation of RNA Pol II elongation complex ", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "Interactions of Tat with host cellular proteins", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Transcription Elongation", "Estrogen-dependent gene expression"], "O60566": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "APC/C:Cdc20 mediated degradation of mitotic proteins", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "O60568": ["Collagen biosynthesis and modifying enzymes"], "O60573": ["ISG15 antiviral mechanism"], "O60583": ["Formation of RNA Pol II elongation complex ", "Formation of HIV elongation complex in the absence of HIV Tat", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Transcription Elongation"], "O60602": ["Toll Like Receptor 5 (TLR5) Cascade", "MyD88 deficiency (TLR5)", "IRAK4 deficiency (TLR5)", "MyD88 cascade initiated on plasma membrane"], "O60603": ["ER-Phagosome pathway", "Beta defensins", "MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "Toll Like Receptor TLR1:TLR2 Cascade", "Toll Like Receptor TLR6:TLR2 Cascade", "MyD88 deficiency (TLR2/4)", "IRAK4 deficiency (TLR2/4)", "Regulation of TLR by endogenous ligand", "Neutrophil degranulation"], "O60609": ["RAF/MAP kinase cascade", "RET signaling"], "O60610": ["RHO GTPases Activate Formins", "ERBB2 Regulates Cell Motility", "Neutrophil degranulation"], "O60641": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "O60645": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Insulin processing", "VxPx cargo-targeting to cilium"], "O60656": ["Glucuronidation", "PPARA activates gene expression"], "O60658": ["G alpha (s) signalling events"], "O60662": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "O60664": ["Triglyceride catabolism", "Retrograde transport at the Trans-Golgi-Network"], "O60669": ["Proton-coupled monocarboxylate transport"], "O60671": ["Activation of ATR in response to replication stress", "HDR through Single Strand Annealing (SSA)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Regulation of TP53 Activity through Phosphorylation", "G2/M DNA damage checkpoint"], "O60673": ["Translesion synthesis by REV1", "Translesion synthesis by POLK", "Translesion synthesis by POLI"], "O60674": ["Interleukin-6 signaling", "Interleukin-6 signaling", "MAPK3 (ERK1) activation", "MAPK1 (ERK2) activation", "Prolactin receptor signaling", "Prolactin receptor signaling", "Signaling by SCF-KIT", "Signaling by Leptin", "RMTs methylate histone arginines", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "RAF activation", "RAF/MAP kinase cascade", "Interleukin-4 and Interleukin-13 signaling", "IL-6-type cytokine receptor ligand interactions", "Signaling by moderate kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF", "Cyclin D associated events in G1", "Interferon gamma signaling", "Regulation of IFNG signaling", "Regulation of IFNG signaling", "Interleukin-20 family signaling", "Interleukin-35 Signalling", "Signaling by Erythropoietin", "Interleukin-12 signaling", "Interleukin-12 signaling", "Interleukin-23 signaling", "Interleukin-23 signaling", "Interleukin-27 signaling", "Interleukin-27 signaling", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "Erythropoietin activates Phospholipase C gamma (PLCG)", "Erythropoietin activates STAT5", "Erythropoietin activates RAS", "Erythropoietin activates RAS", "Interleukin receptor SHC signaling", "Growth hormone receptor signaling", "Growth hormone receptor signaling", "Factors involved in megakaryocyte development and platelet production"], "O60675": ["Factors involved in megakaryocyte development and platelet production", "Factors involved in megakaryocyte development and platelet production"], "O60678": ["RMTs methylate histone arginines", "Protein methylation"], "O60683": ["E3 ubiquitin ligases ubiquitinate target proteins", "Peroxisomal protein import", "Peroxisomal protein import"], "O60701": ["Formation of the active cofactor, UDP-glucuronate"], "O60704": ["Cytosolic sulfonation of small molecules"], "O60706": ["ATP sensitive Potassium channels", "ABC-family proteins mediated transport", "Ion homeostasis", "Defective ABCC9 causes dilated cardiomyopathy 10, familial atrial fibrillation 12 and hypertrichotic osteochondrodysplasia"], "O60716": ["Adherens junctions interactions", "VEGFR2 mediated vascular permeability", "InlA-mediated entry of Listeria monocytogenes into host cells"], "O60721": ["Activation of the phototransduction cascade", "Sodium/Calcium exchangers", "Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D)"], "O60725": ["Gamma carboxylation, hypusine formation and arylsulfatase activation"], "O60729": ["MAPK6/MAPK4 signaling"], "O60733": ["Acyl chain remodelling of PC", "Acyl chain remodeling of CL", "Acyl chain remodelling of PE", "Role of phospholipids in phagocytosis", "COPI-independent Golgi-to-ER retrograde traffic"], "O60741": ["HCN channels"], "O60749": ["Golgi Associated Vesicle Biogenesis"], "O60755": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "O60760": ["Glutathione conjugation", "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"], "O60762": ["Synthesis of dolichyl-phosphate mannose", "Defective DPM1 causes DPM1-CDG (CDG-1e)"], "O60763": ["Golgi Cisternae Pericentriolar Stack Reorganization", "COPII-mediated vesicle transport", "COPI-mediated anterograde transport"], "O60765": ["Generic Transcription Pathway"], "O60779": ["Vitamin B1 (thiamin) metabolism"], "O60783": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "O60784": ["Neutrophil degranulation"], "O60814": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "HATs acetylate histones", "HATs acetylate histones", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Ub-specific processing proteases", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "E3 ubiquitin ligases ubiquitinate target proteins", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "O60825": ["Glycolysis"], "O60826": ["Neddylation"], "O60828": ["mRNA Splicing - Major Pathway"], "O60830": ["Mitochondrial protein import", "Mitochondrial protein import"], "O60832": ["Telomere Extension By Telomerase", "rRNA modification in the nucleus and cytosol"], "O60840": ["Phase 0 - rapid depolarisation", "Phase 2 - plateau phase"], "O60841": ["GTP hydrolysis and joining of the 60S ribosomal subunit"], "O60858": ["ER Quality Control Compartment (ERQC)"], "O60870": ["Protein methylation"], "O60879-2": ["RHO GTPases Activate Formins"], "O60879-3": ["RHO GTPases Activate Formins"], "O60880": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "O60882": ["Collagen degradation", "Degradation of the extracellular matrix", "Degradation of the extracellular matrix", "Assembly of collagen fibrils and other multimeric structures"], "O60883": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "O60884": ["HSP90 chaperone cycle for steroid hormone receptors (SHR)"], "O60890": ["Rho GTPase cycle"], "O60894": ["G alpha (s) signalling events", "Calcitonin-like ligand receptors"], "O60895": ["G alpha (s) signalling events", "Calcitonin-like ligand receptors"], "O60896": ["G alpha (s) signalling events", "Calcitonin-like ligand receptors"], "O60906": ["Glycosphingolipid metabolism", "Ceramide signalling", "TNFR1-mediated ceramide production"], "O60907": ["RORA activates gene expression", "BMAL1:CLOCK,NPAS2 activates circadian gene expression", "PPARA activates gene expression", "PPARA activates gene expression", "NOTCH1 Intracellular Domain Regulates Transcription", "Transcriptional activation of mitochondrial biogenesis", "Activation of gene expression by SREBF (SREBP)", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "HDACs deacetylate histones", "Transcriptional regulation of white adipocyte differentiation", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)", "Circadian Clock", "Loss of MECP2 binding ability to the NCoR/SMRT complex", "Regulation of MECP2 expression and activity"], "O60909": ["Keratan sulfate biosynthesis", "N-Glycan antennae elongation"], "O60911": ["Endosomal/Vacuolar pathway", "Degradation of the extracellular matrix", "Activation of Matrix Metalloproteinases", "Trafficking and processing of endosomal TLR", "Assembly of collagen fibrils and other multimeric structures", "MHC class II antigen presentation", "RUNX1 regulates transcription of genes involved in differentiation of keratinocytes"], "O60921": ["Activation of ATR in response to replication stress", "HDR through Single Strand Annealing (SSA)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Regulation of TP53 Activity through Phosphorylation", "G2/M DNA damage checkpoint"], "O60925": ["Prefoldin mediated transfer of substrate to CCT/TriC"], "O60931": ["Transport of inorganic cations/anions and amino acids/oligopeptides", "Miscellaneous transport and binding events"], "O60934": ["DNA Damage/Telomere Stress Induced Senescence", "HDR through Single Strand Annealing (SSA)", "HDR through MMEJ (alt-NHEJ)", "HDR through Homologous Recombination (HRR)", "Sensing of DNA Double Strand Breaks", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Nonhomologous End-Joining (NHEJ)", "Homologous DNA Pairing and Strand Exchange", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Regulation of TP53 Activity through Phosphorylation", "G2/M DNA damage checkpoint", "Meiotic recombination"], "O60938": ["Keratan sulfate biosynthesis", "Keratan sulfate degradation", "Defective CHST6 causes MCDC1", "Defective ST3GAL3 causes MCT12 and EIEE15", "Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)"], "O60939": ["Interaction between L1 and Ankyrins", "Phase 0 - rapid depolarisation"], "O60942": ["RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "mRNA Capping", "RNA Pol II CTD phosphorylation and interaction with CE"], "O75015": ["Post-translational modification: synthesis of GPI-anchored proteins", "Neutrophil degranulation"], "O75019": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "O75022": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation"], "O75023": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "O75027": ["Mitochondrial ABC transporters", "Cytosolic iron-sulfur cluster assembly"], "O75030": ["SUMOylation of transcription factors"], "O75037": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "O75038": ["Synthesis of IP3 and IP4 in the cytosol"], "O75044": ["Rho GTPase cycle", "Inactivation of CDC42 and RAC1", "RHO GTPases Activate Formins"], "O75051": ["Sema3A PAK dependent Axon repulsion", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "CRMPs in Sema3A signaling", "CRMPs in Sema3A signaling", "Other semaphorin interactions"], "O75056": ["A tetrasaccharide linker sequence is required for GAG synthesis", "HS-GAG biosynthesis", "HS-GAG biosynthesis", "HS-GAG degradation", "Cell surface interactions at the vascular wall", "Syndecan interactions", "Syndecan interactions", "Defective B4GALT7 causes EDS, progeroid type", "Defective B3GAT3 causes JDSSDHD", "Defective EXT2 causes exostoses 2", "Defective EXT1 causes exostoses 1, TRPS2 and CHDS", "Defective B3GALT6 causes EDSP2 and SEMDJL1", "Retinoid metabolism and transport"], "O75061": ["Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis", "Clathrin-mediated endocytosis"], "O75064": ["RAB GEFs exchange GTP for GDP on RABs"], "O75077": ["LGI-ADAM interactions"], "O75078": ["LGI-ADAM interactions"], "O75083": ["Platelet degranulation "], "O75084": ["Class B/2 (Secretin family receptors)", "PCP/CE pathway", "PCP/CE pathway", "Asymmetric localization of PCP proteins"], "O75093": ["Netrin-1 signaling", "Signaling by ROBO receptors", "Regulation of commissural axon pathfinding by SLIT and ROBO", "Regulation of cortical dendrite branching", "Regulation of expression of SLITs and ROBOs"], "O75094": ["Netrin-1 signaling", "Signaling by ROBO receptors", "Signaling by ROBO receptors", "Regulation of commissural axon pathfinding by SLIT and ROBO"], "O75096": ["ECM proteoglycans"], "O75106": ["Phase I - Functionalization of compounds"], "O75110": ["Ion transport by P-type ATPases"], "O75116": ["EPHB-mediated forward signaling", "EPHB-mediated forward signaling", "EPHA-mediated growth cone collapse", "G alpha (12/13) signalling events", "Sema4D induced cell migration and growth-cone collapse", "Sema4D induced cell migration and growth-cone collapse", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate ROCKs", "RHO GTPases Activate ROCKs"], "O75122": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Role of ABL in ROBO-SLIT signaling", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "O75131": ["Glycerophospholipid biosynthesis", "Neutrophil degranulation"], "O75143": ["Macroautophagy"], "O75144": ["Costimulation by the CD28 family"], "O75145": ["Serotonin Neurotransmitter Release Cycle", "Norepinephrine Neurotransmitter Release Cycle", "Glutamate Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle", "Acetylcholine Neurotransmitter Release Cycle", "Receptor-type tyrosine-protein phosphatases"], "O75146": ["Golgi Associated Vesicle Biogenesis", "Clathrin-mediated endocytosis"], "O75147": ["Neddylation"], "O75150": ["E3 ubiquitin ligases ubiquitinate target proteins"], "O75151": ["HDMs demethylate histones"], "O75152": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA 3'-end processing"], "O75154": ["VxPx cargo-targeting to cilium"], "O75159": ["Interleukin-4 and Interleukin-13 signaling", "Neddylation"], "O75161": ["Signaling by Hippo", "Anchoring of the basal body to the plasma membrane"], "O75164": ["HDMs demethylate histones", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"], "O75165": ["Neutrophil degranulation"], "O75167": ["Platelet degranulation "], "O75173": ["Degradation of the extracellular matrix", "Degradation of the extracellular matrix", "Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "O75175": ["Deadenylation of mRNA", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "O75182": ["NoRC negatively regulates rRNA expression", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"], "O75182-1": ["Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)"], "O75185": ["Ion transport by P-type ATPases"], "O75190": ["Regulation of HSF1-mediated heat shock response"], "O75191": ["Formation of xylulose-5-phosphate"], "O75192": ["PPARA activates gene expression"], "O75197": ["TCF dependent signaling in response to WNT", "Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Regulation of FZD by ubiquitination", "Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling", "RNF mutants show enhanced WNT signaling and proliferation"], "O75208": ["Ubiquinol biosynthesis"], "O75223": ["Glutathione synthesis and recycling"], "O75251": ["Respiratory electron transport", "Complex I biogenesis"], "O75306": ["Respiratory electron transport", "Complex I biogenesis"], "O75310": ["Glucuronidation"], "O75311": ["Neurotransmitter receptors and postsynaptic signal transmission"], "O75317": ["Ub-specific processing proteases"], "O75326": ["Other semaphorin interactions", "Other semaphorin interactions"], "O75330": ["Hyaluronan uptake and degradation", "AURKA Activation by TPX2"], "O75334": ["Serotonin Neurotransmitter Release Cycle", "Norepinephrine Neurotransmitter Release Cycle", "Glutamate Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle", "Acetylcholine Neurotransmitter Release Cycle", "Receptor-type tyrosine-protein phosphatases"], "O75335": ["Serotonin Neurotransmitter Release Cycle", "Norepinephrine Neurotransmitter Release Cycle", "Glutamate Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle", "Acetylcholine Neurotransmitter Release Cycle", "Receptor-type tyrosine-protein phosphatases"], "O75339": ["Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)"], "O75342": ["Synthesis of 12-eicosatetraenoic acid derivatives"], "O75343": ["Nitric oxide stimulates guanylate cyclase", "Smooth Muscle Contraction"], "O75344": ["Meiotic synapsis", "PIWI-interacting RNA (piRNA) biogenesis"], "O75346": ["Generic Transcription Pathway"], "O75347": ["Post-chaperonin tubulin folding pathway"], "O75348": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "O75351": ["Budding and maturation of HIV virion", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "O75352": ["Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "Defective MPDU1 causes MPDU1-CDG (CDG-1f)"], "O75354": ["Phosphate bond hydrolysis by NTPDase proteins"], "O75355": ["Phosphate bond hydrolysis by NTPDase proteins"], "O75356": ["Phosphate bond hydrolysis by NTPDase proteins"], "O75362": ["Estrogen-dependent gene expression"], "O75369": ["ISG15 antiviral mechanism"], "O75373": ["Generic Transcription Pathway"], "O75376": ["Nuclear signaling by ERBB4", "Nuclear signaling by ERBB4", "NR1D1 (REV-ERBA) represses gene expression", "PPARA activates gene expression", "NOTCH1 Intracellular Domain Regulates Transcription", "Transcriptional activation of mitochondrial biogenesis", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "HDACs deacetylate histones", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)", "Circadian Clock", "Circadian Clock", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Loss of MECP2 binding ability to the NCoR/SMRT complex", "Regulation of MECP2 expression and activity"], "O75379": ["Retrograde transport at the Trans-Golgi-Network", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "O75380": ["Respiratory electron transport", "Complex I biogenesis"], "O75381": ["E3 ubiquitin ligases ubiquitinate target proteins", "Peroxisomal protein import", "Peroxisomal protein import"], "O75382": ["Interferon gamma signaling"], "O75385": ["Macroautophagy", "TBC/RABGAPs", "RAB GEFs exchange GTP for GDP on RABs", "Receptor Mediated Mitophagy"], "O75386": ["Hedgehog 'off' state"], "O75387": ["Amino acid transport across the plasma membrane"], "O75388": ["G alpha (s) signalling events"], "O75390": ["Mitochondrial protein import", "Citric acid cycle (TCA cycle)"], "O75394": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "O75396": ["ER-Phagosome pathway", "COPII-mediated vesicle transport", "Cargo concentration in the ER", "COPI-dependent Golgi-to-ER retrograde traffic"], "O75400": ["mRNA Splicing - Major Pathway"], "O75417": ["HDR through MMEJ (alt-NHEJ)"], "O75419": ["Activation of ATR in response to replication stress", "Unwinding of DNA", "Activation of E2F1 target genes at G1/S", "Activation of the pre-replicative complex"], "O75431": ["Mitochondrial protein import", "Cristae formation"], "O75436": ["WNT ligand biogenesis and trafficking"], "O75437": ["Generic Transcription Pathway"], "O75438": ["Respiratory electron transport", "Complex I biogenesis"], "O75439": ["Mitochondrial protein import", "Processing of SMDT1"], "O75443": ["Post-translational modification: synthesis of GPI-anchored proteins"], "O75444": ["RUNX2 regulates osteoblast differentiation"], "O75446": ["HDACs deacetylate histones", "NoRC negatively regulates rRNA expression"], "O75448": ["PPARA activates gene expression", "Generic Transcription Pathway", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "O75452": ["The canonical retinoid cycle in rods (twilight vision)", "RA biosynthesis pathway"], "O75460": ["IRE1alpha activates chaperones", "IRE1alpha activates chaperones"], "O75461": ["Activation of E2F1 target genes at G1/S", "Transcriptional Regulation by E2F6"], "O75462": ["IL-6-type cytokine receptor ligand interactions", "Interleukin-27 signaling"], "O75467": ["Generic Transcription Pathway"], "O75469-1": ["Nuclear Receptor transcription pathway", "SUMOylation of intracellular receptors"], "O75469-2": ["Nuclear Receptor transcription pathway"], "O75469-3": ["Nuclear Receptor transcription pathway"], "O75469-4": ["Nuclear Receptor transcription pathway"], "O75469-5": ["Nuclear Receptor transcription pathway"], "O75469-6": ["Nuclear Receptor transcription pathway"], "O75469-7": ["Nuclear Receptor transcription pathway"], "O75473": ["Regulation of FZD by ubiquitination"], "O75474": ["Beta-catenin phosphorylation cascade", "Disassembly of the destruction complex and recruitment of AXIN to the membrane"], "O75475": ["Integration of provirus", "2-LTR circle formation", "Integration of viral DNA into host genomic DNA", "Autointegration results in viral DNA circles", "APOBEC3G mediated resistance to HIV-1 infection", "Vpr-mediated nuclear import of PICs"], "O75477": ["ABC-family proteins mediated transport", "Defective CFTR causes cystic fibrosis"], "O75478": ["HATs acetylate histones"], "O75486": ["HATs acetylate histones"], "O75487": ["A tetrasaccharide linker sequence is required for GAG synthesis", "HS-GAG biosynthesis", "HS-GAG biosynthesis", "HS-GAG degradation", "Defective B4GALT7 causes EDS, progeroid type", "Defective B3GAT3 causes JDSSDHD", "Defective EXT2 causes exostoses 2", "Defective EXT1 causes exostoses 1, TRPS2 and CHDS", "Defective B3GALT6 causes EDSP2 and SEMDJL1", "Retinoid metabolism and transport"], "O75489": ["Respiratory electron transport", "Complex I biogenesis"], "O75494": ["mRNA Splicing - Major Pathway"], "O75496": ["CDT1 association with the CDC6:ORC:origin complex", "Activation of the pre-replicative complex"], "O75506": ["HSF1 activation", "Attenuation phase", "HSF1-dependent transactivation"], "O75508": ["Tight junction interactions"], "O75509": ["PPARA activates gene expression"], "O75521-2": ["Beta-oxidation of very long chain fatty acids", "Peroxisomal protein import", "Peroxisomal protein import"], "O75525": ["PTK6 Regulates Proteins Involved in RNA Processing"], "O75528": ["HATs acetylate histones", "Ub-specific processing proteases"], "O75529": ["HATs acetylate histones"], "O75530": ["PRC2 methylates histones and DNA", "Oxidative Stress Induced Senescence", "PKMTs methylate histone lysines", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription", "Transcriptional Regulation by E2F6"], "O75531": ["Integration of provirus", "2-LTR circle formation", "Integration of viral DNA into host genomic DNA", "Autointegration results in viral DNA circles", "APOBEC3G mediated resistance to HIV-1 infection", "Vpr-mediated nuclear import of PICs", "Clearance of Nuclear Envelope Membranes from Chromatin", "Initiation of Nuclear Envelope Reformation"], "O75533": ["B-WICH complex positively regulates rRNA expression", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "O75553": ["Reelin signalling pathway"], "O75554": ["mRNA Splicing - Major Pathway"], "O75563": ["Signal regulatory protein family interactions"], "O75569": ["MicroRNA (miRNA) biogenesis", "Small interfering RNA (siRNA) biogenesis"], "O75575": ["Cytosolic sensors of pathogen-associated DNA ", "RNA Polymerase III Chain Elongation", "RNA Polymerase III Transcription Termination", "RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "O75578": ["Integrin cell surface interactions", "Integrin cell surface interactions", "CHL1 interactions", "Platelet Adhesion to exposed collagen"], "O75581": ["TCF dependent signaling in response to WNT", "Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Regulation of FZD by ubiquitination", "RNF mutants show enhanced WNT signaling and proliferation"], "O75582": ["ERK/MAPK targets", "CREB phosphorylation", "NCAM signaling for neurite out-growth", "Recycling pathway of L1", "CD209 (DC-SIGN) signaling"], "O75586": ["PPARA activates gene expression", "Generic Transcription Pathway", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "O75593": ["Signaling by NODAL", "Signaling by Activin"], "O75594": ["Neutrophil degranulation", "Antimicrobial peptides"], "O75600": ["Threonine catabolism"], "O75604": ["TNFR1-induced proapoptotic signaling", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "Ub-specific processing proteases", "Regulation of TP53 Degradation"], "O75608": ["eNOS activation"], "O75610": ["Signaling by NODAL", "Regulation of signaling by NODAL"], "O75616": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "O75626": ["Regulation of TP53 Expression"], "O75629": ["Neutrophil degranulation"], "O75636": ["Lectin pathway of complement activation", "Initial triggering of complement", "Ficolins bind to repetitive carbohydrate structures on the target cell surface"], "O75643": ["mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "O75648": ["tRNA modification in the mitochondrion"], "O75665": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Hedgehog 'off' state", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "O75676": ["Recycling pathway of L1"], "O75688": ["ISG15 antiviral mechanism"], "O75690": ["Keratinization"], "O75691": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "O75694": ["ISG15 antiviral mechanism", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "tRNA processing in the nucleus"], "O75695": ["Trafficking of myristoylated proteins to the cilium"], "O75712": ["Gap junction assembly"], "O75715": ["Detoxification of Reactive Oxygen Species"], "O75718": ["Collagen biosynthesis and modifying enzymes"], "O75746": ["Mitochondrial protein import", "Gluconeogenesis"], "O75747": ["Synthesis of PIPs at the plasma membrane", "Synthesis of PIPs at the Golgi membrane"], "O75751": ["Abacavir transmembrane transport", "Organic cation transport"], "O75752": ["Glycosphingolipid metabolism"], "O75762": ["TRP channels"], "O75771": ["HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange", "Presynaptic phase of homologous DNA pairing and strand exchange", "TP53 Regulates Transcription of DNA Repair Genes"], "O75787": ["Metabolism of Angiotensinogen to Angiotensins", "Neutrophil degranulation"], "O75791": ["Signaling by SCF-KIT", "Generation of second messenger molecules", "DAP12 signaling", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "CD28 co-stimulation"], "O75795": ["Glucuronidation"], "O75807": ["Downregulation of TGF-beta receptor signaling"], "O75808": ["Degradation of the extracellular matrix"], "O75817": ["tRNA processing in the nucleus"], "O75818": ["tRNA processing in the nucleus", "Major pathway of rRNA processing in the nucleolus and cytosol"], "O75820": ["Generic Transcription Pathway"], "O75821": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "O75822": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "O75828": ["Phase I - Functionalization of compounds"], "O75832": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "O75843": ["Lysosome Vesicle Biogenesis"], "O75845": ["Activation of gene expression by SREBF (SREBP)", "Cholesterol biosynthesis via desmosterol", "Cholesterol biosynthesis via lathosterol"], "O75865": ["COPII-mediated vesicle transport", "RAB GEFs exchange GTP for GDP on RABs"], "O75874": ["Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate", "NADPH regeneration", "Neutrophil degranulation", "Peroxisomal protein import", "Peroxisomal protein import"], "O75880": ["TP53 Regulates Metabolic Genes", "Respiratory electron transport"], "O75881": ["Synthesis of bile acids and bile salts", "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "Endogenous sterols", "Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3)"], "O75886": ["EGFR downregulation", "Ub-specific processing proteases", "Negative regulation of MET activity", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "InlB-mediated entry of Listeria monocytogenes into host cell", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "O75888": ["HuR (ELAVL1) binds and stabilizes mRNA", "TNFs bind their physiological receptors"], "O75891": ["Metabolism of folate and pterines"], "O75897": ["Cytosolic sulfonation of small molecules"], "O75899": ["Activation of G protein gated Potassium channels", "G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)", "GABA B receptor activation", "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "O75907": ["Acyl chain remodeling of DAG and TAG", "Neutrophil degranulation", "Triglyceride biosynthesis"], "O75908": ["LDL clearance"], "O75909": ["Formation of RNA Pol II elongation complex ", "Formation of HIV elongation complex in the absence of HIV Tat", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Transcription Elongation"], "O75911": ["The retinoid cycle in cones (daylight vision)", "RA biosynthesis pathway"], "O75912": ["Effects of PIP2 hydrolysis"], "O75914": ["Generation of second messenger molecules", "CD28 dependent Vav1 pathway", "Ephrin signaling", "Sema3A PAK dependent Axon repulsion", "Activation of RAC1", "VEGFR2 mediated vascular permeability", "CD209 (DC-SIGN) signaling", "RHO GTPases activate PAKs", "RHO GTPases activate PAKs", "MAPK6/MAPK4 signaling"], "O75915": ["Glutamate Neurotransmitter Release Cycle"], "O75916": ["G alpha (i) signalling events", "G alpha (i) signalling events", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "O75916-3": ["Inactivation, recovery and regulation of the phototransduction cascade", "Inactivation, recovery and regulation of the phototransduction cascade"], "O75923": ["Smooth Muscle Contraction", "Smooth Muscle Contraction"], "O75925": ["SUMOylation of DNA damage response and repair proteins", "SUMOylation of transcription factors", "SUMOylation of ubiquitinylation proteins", "SUMOylation of transcription cofactors", "SUMOylation of intracellular receptors", "SUMOylation of intracellular receptors", "SUMOylation of chromatin organization proteins", "Formation of Incision Complex in GG-NER", "Regulation of IFNG signaling"], "O75928": ["Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "O75928-1": ["SUMOylation of DNA damage response and repair proteins", "SUMOylation of transcription factors", "SUMOylation of ubiquitinylation proteins", "SUMOylation of transcription cofactors", "SUMOylation of intracellular receptors"], "O75928-2": ["SUMOylation of intracellular receptors", "SUMOylation of intracellular receptors", "SUMOylation of chromatin organization proteins"], "O75934": ["mRNA Splicing - Major Pathway"], "O75935": ["MHC class II antigen presentation", "Regulation of PLK1 Activity at G2/M Transition", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic", "AURKA Activation by TPX2"], "O75936": ["Carnitine synthesis"], "O75937": ["mRNA Splicing - Major Pathway"], "O75940": ["mRNA Splicing - Major Pathway"], "O75943": ["Activation of ATR in response to replication stress", "HDR through Single Strand Annealing (SSA)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Regulation of TP53 Activity through Phosphorylation", "G2/M DNA damage checkpoint"], "O75947": ["Formation of ATP by chemiosmotic coupling", "Cristae formation"], "O75955": ["Synaptic adhesion-like molecules"], "O75962": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "DCC mediated attractive signaling", "DCC mediated attractive signaling"], "O75964": ["Formation of ATP by chemiosmotic coupling", "Cristae formation"], "O75971": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "O75976": ["Golgi Associated Vesicle Biogenesis"], "O76000": ["Olfactory Signaling Pathway"], "O76001": ["Olfactory Signaling Pathway"], "O76002": ["Olfactory Signaling Pathway"], "O76003": ["Iron uptake and transport"], "O76009": ["Keratinization", "Formation of the cornified envelope"], "O76011": ["Keratinization", "Formation of the cornified envelope"], "O76013": ["Keratinization", "Formation of the cornified envelope"], "O76014": ["Keratinization", "Formation of the cornified envelope"], "O76015": ["Keratinization", "Formation of the cornified envelope"], "O76024": ["XBP1(S) activates chaperone genes", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "O76036": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "O76050": ["Activated NOTCH1 Transmits Signal to the Nucleus", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "NOTCH2 Activation and Transmission of Signal to the Nucleus", "NOTCH3 Activation and Transmission of Signal to the Nucleus"], "O76061": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "O76062": ["Cholesterol biosynthesis", "Activation of gene expression by SREBF (SREBP)"], "O76064": ["Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "G2/M DNA damage checkpoint"], "O76071": ["Cytosolic iron-sulfur cluster assembly"], "O76074": ["cGMP effects"], "O76075": ["Activation of DNA fragmentation factor"], "O76081": ["G alpha (i) signalling events", "G alpha (i) signalling events", "G alpha (z) signalling events", "G alpha (z) signalling events"], "O76082": ["Import of palmitoyl-CoA into the mitochondrial matrix", "Organic cation transport", "Defective SLC22A5 causes systemic primary carnitine deficiency (CDSP)"], "O76083": ["cGMP effects"], "O76090": ["Stimuli-sensing channels"], "O76093": ["PI3K Cascade", "PIP3 activates AKT signaling", "Signaling by activated point mutants of FGFR3", "FGFR4 ligand binding and activation", "FGFR3b ligand binding and activation", "FGFR3c ligand binding and activation", "FGFR2c ligand binding and activation", "FGFR3 mutant receptor activation", "Activated point mutants of FGFR2", "Constitutive Signaling by Aberrant PI3K in Cancer", "Phospholipase C-mediated cascade; FGFR2", "Phospholipase C-mediated cascade; FGFR3", "Phospholipase C-mediated cascade; FGFR4", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "PI-3K cascade:FGFR3", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "PI-3K cascade:FGFR4", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "Signaling by FGFR2 in disease", "FGFRL1 modulation of FGFR1 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Signaling by FGFR3 point mutants in cancer"], "O76094": ["SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane"], "O76099": ["Olfactory Signaling Pathway"], "O76100": ["Olfactory Signaling Pathway"], "O94759": ["TRP channels", "Neutrophil degranulation"], "O94760": ["eNOS activation"], "O94766": ["A tetrasaccharide linker sequence is required for GAG synthesis", "Defective B3GAT3 causes JDSSDHD"], "O94772": ["Post-translational modification: synthesis of GPI-anchored proteins"], "O94776": ["HDACs deacetylate histones", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "Regulation of TP53 Activity through Acetylation", "RNA Polymerase I Transcription Initiation", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription"], "O94777": ["Synthesis of dolichyl-phosphate mannose", "Synthesis of glycosylphosphatidylinositol (GPI)", "Defective DPM2 causes DPM2-CDG (CDG-1u)"], "O94778": ["Detoxification of Reactive Oxygen Species", "Passive transport by Aquaporins"], "O94779": ["Post-translational modification: synthesis of GPI-anchored proteins"], "O94782": ["Recognition of DNA damage by PCNA-containing replication complex", "Fanconi Anemia Pathway"], "O94788": ["RA biosynthesis pathway"], "O94804": ["Neutrophil degranulation"], "O94805": ["RMTs methylate histone arginines", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "O94806": ["Sphingolipid de novo biosynthesis"], "O94808": ["Synthesis of UDP-N-acetyl-glucosamine"], "O94810": ["G alpha (i) signalling events", "G alpha (i) signalling events", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "O94813": ["Netrin-1 signaling", "Signaling by ROBO receptors", "Signaling by ROBO receptors", "Activation of RAC1", "Regulation of commissural axon pathfinding by SLIT and ROBO", "Inactivation of CDC42 and RAC1", "Role of ABL in ROBO-SLIT signaling", "Role of ABL in ROBO-SLIT signaling", "SLIT2:ROBO1 increases RHOA activity", "Regulation of expression of SLITs and ROBOs", "Regulation of expression of SLITs and ROBOs"], "O94817": ["Macroautophagy", "Macroautophagy", "Pink/Parkin Mediated Mitophagy", "Receptor Mediated Mitophagy", "Negative regulators of DDX58/IFIH1 signaling"], "O94822": ["Antigen processing: Ubiquitination & Proteasome degradation"], "O94823": ["Ion transport by P-type ATPases"], "O94826": ["Mitochondrial protein import", "Pink/Parkin Mediated Mitophagy", "Ub-specific processing proteases"], "O94827": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "O94830": ["Synthesis of PA"], "O94844": ["Rho GTPase cycle"], "O94855": ["Regulation of cholesterol biosynthesis by SREBP (SREBF)", "COPII-mediated vesicle transport", "MHC class II antigen presentation", "Cargo concentration in the ER", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "O94856": ["Interaction between L1 and Ankyrins", "Neurofascin interactions", "Neurofascin interactions", "Neutrophil degranulation"], "O94864": ["HATs acetylate histones"], "O94874": ["Antigen processing: Ubiquitination & Proteasome degradation"], "O94886": ["Neutrophil degranulation"], "O94887": ["SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion"], "O94888": ["Neddylation"], "O94892": ["Generic Transcription Pathway"], "O94901": ["Meiotic synapsis"], "O94905": ["ABC-family proteins mediated transport", "Signaling by FGFR1 in disease", "Defective CFTR causes cystic fibrosis", "Signaling by plasma membrane FGFR1 fusions"], "O94906": ["mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "O94907": ["TCF dependent signaling in response to WNT", "Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling"], "O94911": ["ABC-family proteins mediated transport"], "O94913": ["Cleavage of Growing Transcript in the Termination Region ", "RNA polymerase II transcribes snRNA genes", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "O94919": ["Platelet degranulation "], "O94923": ["HS-GAG biosynthesis"], "O94925": ["Glutamate Neurotransmitter Release Cycle", "TP53 Regulates Metabolic Genes", "Amino acid synthesis and interconversion (transamination)"], "O94927": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "O94929": ["DCC mediated attractive signaling"], "O94933": ["Receptor-type tyrosine-protein phosphatases"], "O94941": ["Antigen processing: Ubiquitination & Proteasome degradation"], "O94952": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "O94953": ["HDMs demethylate histones", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Estrogen-dependent gene expression"], "O94955": ["Retrograde transport at the Trans-Golgi-Network"], "O94956": ["Transport of organic anions"], "O94966": ["Ub-specific processing proteases"], "O94972": ["Antigen processing: Ubiquitination & Proteasome degradation"], "O94973": ["Nef Mediated CD4 Down-regulation", "Retrograde neurotrophin signalling", "Retrograde neurotrophin signalling", "Nef Mediated CD8 Down-regulation", "MHC class II antigen presentation", "EPH-ephrin mediated repulsion of cells", "Recycling pathway of L1", "Recycling pathway of L1", "WNT5A-dependent internalization of FZD4", "WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "Neutrophil degranulation", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "VLDLR internalisation and degradation", "LDL clearance"], "O94973-3": ["Trafficking of GluR2-containing AMPA receptors"], "O94979": ["COPII-mediated vesicle transport", "MHC class II antigen presentation", "XBP1(S) activates chaperone genes", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "O94986": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "O94988": ["Rho GTPase cycle"], "O94989": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "O94991": ["Receptor-type tyrosine-protein phosphatases"], "O95006": ["Olfactory Signaling Pathway"], "O95007": ["Olfactory Signaling Pathway"], "O95013": ["Olfactory Signaling Pathway"], "O95045": ["Pyrimidine salvage", "Pyrimidine catabolism"], "O95047": ["Olfactory Signaling Pathway"], "O95050": ["Methylation of MeSeH for excretion"], "O95059": ["tRNA processing in the nucleus", "Major pathway of rRNA processing in the nucleolus and cytosol"], "O95067": ["Polo-like kinase mediated events", "Golgi Cisternae Pericentriolar Stack Reorganization", "Resolution of Sister Chromatid Cohesion", "Condensation of Prometaphase Chromosomes", "Regulation of PLK1 Activity at G2/M Transition", "Activation of NIMA Kinases NEK9, NEK6, NEK7", "Nuclear Pore Complex (NPC) Disassembly", "Cyclin A/B1/B2 associated events during G2/M transition", "G2/M DNA replication checkpoint", "The role of GTSE1 in G2/M progression after G2 checkpoint"], "O95069": ["TWIK related potassium channel (TREK)", "Phase 4 - resting membrane potential"], "O95070": ["XBP1(S) activates chaperone genes"], "O95072": ["Meiotic synapsis"], "O95084": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "O95096": ["Regulation of gene expression in beta cells", "Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells"], "O95125": ["Generic Transcription Pathway"], "O95136": ["G alpha (i) signalling events", "Lysosphingolipid and LPA receptors"], "O95139": ["Respiratory electron transport", "Complex I biogenesis"], "O95140": ["Pink/Parkin Mediated Mitophagy", "Factors involved in megakaryocyte development and platelet production"], "O95149": ["snRNP Assembly"], "O95150": ["TNFs bind their physiological receptors"], "O95153": ["Serotonin Neurotransmitter Release Cycle", "Norepinephrine Neurotransmitter Release Cycle", "Pregnenolone biosynthesis", "Glutamate Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle", "Acetylcholine Neurotransmitter Release Cycle"], "O95154": ["Aflatoxin activation and detoxification"], "O95163": ["HATs acetylate histones"], "O95166": ["Macroautophagy", "TBC/RABGAPs"], "O95167": ["Respiratory electron transport", "Complex I biogenesis"], "O95168": ["Respiratory electron transport", "Complex I biogenesis"], "O95169": ["Mitochondrial protein import", "Mitochondrial protein import", "Respiratory electron transport", "Complex I biogenesis"], "O95178": ["Respiratory electron transport", "Complex I biogenesis"], "O95180": ["NCAM1 interactions"], "O95182": ["Respiratory electron transport", "Complex I biogenesis"], "O95185": ["Netrin mediated repulsion signals"], "O95190": ["Regulation of ornithine decarboxylase (ODC)"], "O95196": ["A tetrasaccharide linker sequence is required for GAG synthesis", "Chondroitin sulfate biosynthesis", "Dermatan sulfate biosynthesis", "CS/DS degradation", "Defective B4GALT7 causes EDS, progeroid type", "Defective B3GAT3 causes JDSSDHD", "Defective CHST3 causes SEDCJD", "Defective CHST14 causes EDS, musculocontractural type", "Defective CHSY1 causes TPBS", "Defective B3GALT6 causes EDSP2 and SEMDJL1"], "O95197": ["Synaptic adhesion-like molecules"], "O95198": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "O95201": ["Generic Transcription Pathway"], "O95202": ["Mitochondrial calcium ion transport"], "O95208": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "O95210": ["Neutrophil degranulation"], "O95221": ["Olfactory Signaling Pathway"], "O95222": ["Olfactory Signaling Pathway"], "O95229": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "O95235": ["MHC class II antigen presentation", "COPI-dependent Golgi-to-ER retrograde traffic", "Mitotic Telophase/Cytokinesis", "Kinesins"], "O95237": ["Retinoid cycle disease events", "The canonical retinoid cycle in rods (twilight vision)", "Retinoid metabolism and transport"], "O95239": ["MHC class II antigen presentation", "Recycling pathway of L1", "Recycling pathway of L1", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "O95243": ["Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "Cleavage of the damaged pyrimidine ", "Displacement of DNA glycosylase by APEX1"], "O95248": ["Synthesis of PIPs at the ER membrane", "RAB GEFs exchange GTP for GDP on RABs"], "O95249": ["COPI-mediated anterograde transport", "Intra-Golgi traffic"], "O95251": ["HATs acetylate histones"], "O95255": ["ABC-family proteins mediated transport", "Defective ABCC6 causes pseudoxanthoma elasticum (PXE)"], "O95256": ["Interleukin-18 signaling"], "O95258": ["The fatty acid cycling model", "The proton buffering model"], "O95259": ["Voltage gated Potassium channels"], "O95263": ["G alpha (s) signalling events"], "O95264": ["Neurotransmitter receptors and postsynaptic signal transmission"], "O95267": ["Effects of PIP2 hydrolysis", "Activation of RAS in B cells", "Activation of RAS in B cells", "FCERI mediated NF-kB activation", "Integrin alphaIIb beta3 signaling", "Rap1 signalling", "RAF/MAP kinase cascade"], "O95271": ["TCF dependent signaling in response to WNT", "Degradation of AXIN", "XAV939 inhibits tankyrase, stabilizing AXIN", "Ub-specific processing proteases", "Regulation of PTEN stability and activity"], "O95274": ["Post-translational modification: synthesis of GPI-anchored proteins"], "O95278": ["Glycogen synthesis", "Myoclonic epilepsy of Lafora"], "O95279": ["Phase 4 - resting membrane potential"], "O95292": ["Sphingolipid de novo biosynthesis"], "O95294": ["Regulation of RAS by GAPs", "Signaling by RAS mutants"], "O95295": ["Golgi Associated Vesicle Biogenesis"], "O95298": ["Respiratory electron transport", "Neutrophil degranulation", "Complex I biogenesis"], "O95299": ["Respiratory electron transport", "Complex I biogenesis"], "O95302": ["Association of TriC/CCT with target proteins during biosynthesis"], "O95336": ["Pentose phosphate pathway"], "O95340": ["Transport and synthesis of PAPS", "Metabolism of ingested H2SeO4 and H2SeO3 into H2Se", "Defective PAPSS2 causes SEMD-PA"], "O95342": ["Recycling of bile acids and salts", "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Defective ABCB11 causes progressive familial intrahepatic cholestasis 2 and benign recurrent intrahepatic cholestasis 2"], "O95347": ["Condensation of Prophase Chromosomes", "Condensation of Prometaphase Chromosomes", "Condensation of Prometaphase Chromosomes"], "O95352": ["Macroautophagy", "Macroautophagy", "Neutrophil degranulation", "Signaling by BRAF and RAF fusions", "Antigen processing: Ubiquitination & Proteasome degradation"], "O95363": ["Mitochondrial tRNA aminoacylation"], "O95371": ["Olfactory Signaling Pathway"], "O95372": ["L1CAM interactions"], "O95376": ["Antigen processing: Ubiquitination & Proteasome degradation"], "O95377": ["Gap junction assembly"], "O95379": ["PI Metabolism"], "O95391": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing"], "O95393": ["Signaling by BMP", "Molecules associated with elastic fibres"], "O95394": ["Synthesis of UDP-N-acetyl-glucosamine"], "O95395": ["O-linked glycosylation of mucins"], "O95396": ["Molybdenum cofactor biosynthesis"], "O95398": ["Integrin alphaIIb beta3 signaling", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Rap1 signalling", "Regulation of insulin secretion"], "O95399": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "O95400": ["mRNA Splicing - Major Pathway"], "O95402": ["PPARA activates gene expression", "Generic Transcription Pathway", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "O95405-1": ["Downregulation of TGF-beta receptor signaling", "TGF-beta receptor signaling activates SMADs", "SMAD2/3 Phosphorylation Motif Mutants in Cancer", "SMAD2/3 MH2 Domain Mutants in Cancer", "TGFBR1 KD Mutants in Cancer"], "O95406": ["COPII-mediated vesicle transport", "Cargo concentration in the ER"], "O95407": ["TNFs bind their physiological receptors"], "O95415": ["Neutrophil degranulation"], "O95427": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "O95429": ["Regulation of HSF1-mediated heat shock response", "Signaling by FGFR1 in disease", "TNF signaling", "Signaling by plasma membrane FGFR1 fusions"], "O95436": ["Type II Na+/Pi cotransporters", "Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM)", "Surfactant metabolism", "Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM)"], "O95445": ["Retinoid metabolism and transport"], "O95450": ["Collagen biosynthesis and modifying enzymes", "Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "O95452": ["Gap junction assembly"], "O95453": ["ATF4 activates genes", "Deadenylation of mRNA", "KSRP (KHSRP) binds and destabilizes mRNA"], "O95460": ["ECM proteoglycans"], "O95461": ["Defective LARGE causes MDDGA6 and MDDGB6", "O-linked glycosylation"], "O95466": ["RHO GTPases Activate Formins", "RHO GTPases Activate Formins"], "O95470": ["Sphingolipid de novo biosynthesis"], "O95471": ["Tight junction interactions"], "O95476": ["Depolymerisation of the Nuclear Lamina"], "O95477": ["PPARA activates gene expression", "Defective ABCA1 causes Tangier disease", "HDL assembly"], "O95484": ["Tight junction interactions"], "O95486": ["Regulation of cholesterol biosynthesis by SREBP (SREBF)", "COPII-mediated vesicle transport", "MHC class II antigen presentation", "Cargo concentration in the ER", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "O95487": ["Regulation of cholesterol biosynthesis by SREBP (SREBF)", "COPII-mediated vesicle transport", "MHC class II antigen presentation", "Cargo concentration in the ER", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "O95497": ["Post-translational modification: synthesis of GPI-anchored proteins", "Vitamin B5 (pantothenate) metabolism", "Neutrophil degranulation"], "O95498": ["Post-translational modification: synthesis of GPI-anchored proteins", "Vitamin B5 (pantothenate) metabolism"], "O95500": ["Tight junction interactions"], "O95503": ["Oxidative Stress Induced Senescence", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription"], "O95528": ["Cellular hexose transport", "Defective SLC2A10 causes arterial tortuosity syndrome (ATS)"], "O95544": ["Nicotinate metabolism"], "O95551": ["Nonhomologous End-Joining (NHEJ)"], "O95563": ["Pyruvate metabolism"], "O95571": ["Sulfide oxidation to sulfate"], "O95573": ["Synthesis of very long-chain fatty acyl-CoAs"], "O95602": ["NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase I Transcription Termination"], "O95613": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "O95619": ["HATs acetylate histones", "Activation of the TFAP2 (AP-2) family of transcription factors"], "O95622": ["Glucagon signaling in metabolic regulation", "PKA activation", "PKA activation in glucagon signalling", "Adenylate cyclase activating pathway", "Adenylate cyclase inhibitory pathway", "Adenylate cyclase inhibitory pathway", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Adrenaline,noradrenaline inhibits insulin secretion", "G alpha (s) signalling events", "G alpha (s) signalling events", "G alpha (i) signalling events", "G alpha (z) signalling events", "G alpha (z) signalling events", "Vasopressin regulates renal water homeostasis via Aquaporins", "Hedgehog 'off' state"], "O95628": ["Deadenylation of mRNA", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "O95630": ["Metalloprotease DUBs"], "O95631": ["Netrin-1 signaling", "Netrin-1 signaling", "DSCAM interactions", "DCC mediated attractive signaling", "DCC mediated attractive signaling", "Netrin mediated repulsion signals", "Role of second messengers in netrin-1 signaling", "Regulation of commissural axon pathfinding by SLIT and ROBO"], "O95633": ["Antagonism of Activin by Follistatin", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "O95639": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA Derived from an Intronless Transcript", "Inhibition of Host mRNA Processing and RNA Silencing", "tRNA processing in the nucleus", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "O95644": ["Calcineurin activates NFAT", "Calcineurin activates NFAT", "FCERI mediated Ca+2 mobilization", "Ca2+ pathway", "CLEC7A (Dectin-1) induces NFAT activation"], "O95665": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "O95670": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "O95674": ["Synthesis of PG"], "O95677": ["Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"], "O95678": ["Keratinization", "Formation of the cornified envelope"], "O95684": ["Signaling by cytosolic FGFR1 fusion mutants", "Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "Signaling by FGFR1 in disease", "AURKA Activation by TPX2"], "O95696": ["HATs acetylate histones", "Regulation of TP53 Activity through Acetylation"], "O95707": ["tRNA processing in the nucleus"], "O95711": ["Toll Like Receptor 4 (TLR4) Cascade"], "O95714": ["SUMOylation of DNA damage response and repair proteins", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "G2/M DNA damage checkpoint", "Antigen processing: Ubiquitination & Proteasome degradation"], "O95716": ["Neutrophil degranulation", "RAB geranylgeranylation"], "O95718": ["Nuclear Receptor transcription pathway"], "O95721": ["Neutrophil degranulation", "Intra-Golgi traffic"], "O95727": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "O95741": ["Glycerophospholipid biosynthesis"], "O95749": ["Cholesterol biosynthesis", "Activation of gene expression by SREBF (SREBP)"], "O95750": ["PI3K Cascade", "PIP3 activates AKT signaling", "betaKlotho-mediated ligand binding", "FGFR4 ligand binding and activation", "Constitutive Signaling by Aberrant PI3K in Cancer", "Phospholipase C-mediated cascade; FGFR4", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "PI-3K cascade:FGFR4", "Negative regulation of FGFR4 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "O95755": ["Intra-Golgi traffic", "RAB geranylgeranylation"], "O95757": ["Regulation of HSF1-mediated heat shock response"], "O95760": ["PIP3 activates AKT signaling", "Ub-specific processing proteases", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Interleukin-33 signaling"], "O95772": ["Pregnenolone biosynthesis"], "O95777": ["mRNA Splicing - Major Pathway"], "O95780": ["Generic Transcription Pathway"], "O95782": ["Nef Mediated CD4 Down-regulation", "Retrograde neurotrophin signalling", "Retrograde neurotrophin signalling", "Nef Mediated CD8 Down-regulation", "MHC class II antigen presentation", "EPH-ephrin mediated repulsion of cells", "Trafficking of GluR2-containing AMPA receptors", "Recycling pathway of L1", "Recycling pathway of L1", "WNT5A-dependent internalization of FZD4", "WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "VLDLR internalisation and degradation", "LDL clearance"], "O95786": ["ISG15 antiviral mechanism", "DDX58/IFIH1-mediated induction of interferon-alpha/beta", "Ub-specific processing proteases", "Ovarian tumor domain proteases", "OAS antiviral response", "TRAF3-dependent IRF activation pathway", "TRAF6 mediated IRF7 activation", "TRAF6 mediated NF-kB activation", "TRAF6 mediated NF-kB activation", "NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10", "Negative regulators of DDX58/IFIH1 signaling", "Negative regulators of DDX58/IFIH1 signaling"], "O95803": ["HS-GAG biosynthesis"], "O95813": ["Signaling by NODAL", "Regulation of signaling by NODAL", "Signaling by BMP"], "O95816": ["Regulation of HSF1-mediated heat shock response"], "O95817": ["Regulation of HSF1-mediated heat shock response"], "O95819": ["Oxidative Stress Induced Senescence"], "O95822-2": ["Beta-oxidation of very long chain fatty acids", "Peroxisomal protein import", "Peroxisomal protein import"], "O95832": ["Tight junction interactions"], "O95835": ["Signaling by Hippo"], "O95837": ["Acetylcholine regulates insulin secretion", "Acetylcholine regulates insulin secretion", "G alpha (q) signalling events", "G alpha (q) signalling events", "ADP signalling through P2Y purinoceptor 1", "ADP signalling through P2Y purinoceptor 1", "Thromboxane signalling through TP receptor", "Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "Thrombin signalling through proteinase activated receptors (PARs)"], "O95838": ["G alpha (s) signalling events", "Glucagon-type ligand receptors"], "O95843": ["Inactivation, recovery and regulation of the phototransduction cascade"], "O95847": ["The fatty acid cycling model", "The proton buffering model"], "O95848": ["Synthesis of dolichyl-phosphate-glucose"], "O95858": ["Amyloid fiber formation"], "O95861": ["Cytosolic sulfonation of small molecules"], "O95863": ["Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription"], "O95864": ["Linoleic acid (LA) metabolism", "alpha-linolenic acid (ALA) metabolism", "alpha-linolenic acid (ALA) metabolism"], "O95865": ["eNOS activation"], "O95866": ["GPVI-mediated activation cascade"], "O95867": ["Post-translational modification: synthesis of GPI-anchored proteins"], "O95868": ["Post-translational modification: synthesis of GPI-anchored proteins"], "O95886": ["Neurexins and neuroligins", "Neurexins and neuroligins"], "O95907": ["Basigin interactions", "Proton-coupled monocarboxylate transport", "Pyruvate metabolism"], "O95918": ["Olfactory Signaling Pathway"], "O95922": ["Carboxyterminal post-translational modifications of tubulin"], "O95925": ["Antimicrobial peptides"], "O95926": ["mRNA Splicing - Major Pathway"], "O95944": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "DAP12 interactions"], "O95954": ["Histidine catabolism"], "O95965": ["RUNX2 regulates genes involved in cell migration"], "O95967": ["Molecules associated with elastic fibres", "Molecules associated with elastic fibres"], "O95970": ["LGI-ADAM interactions"], "O95971": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "O95972": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "O95977": ["G alpha (i) signalling events", "Lysosphingolipid and LPA receptors"], "O95980": ["Post-translational modification: synthesis of GPI-anchored proteins"], "O95983": ["HDACs deacetylate histones", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "Regulation of TP53 Activity through Acetylation", "RNA Polymerase I Transcription Initiation", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription"], "O95989": ["Synthesis of pyrophosphates in the cytosol"], "O95992": ["Synthesis of bile acids and bile salts"], "O95995": ["Activation of SMO"], "O95997": ["APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Separation of Sister Chromatids"], "O95998": ["Interleukin-37 signaling", "Interleukin-18 signaling"], "O95999": ["Activation of NF-kappaB in B cells", "Activation of NF-kappaB in B cells", "Downstream TCR signaling", "FCERI mediated NF-kB activation", "FCERI mediated NF-kB activation", "CLEC7A (Dectin-1) signaling", "E3 ubiquitin ligases ubiquitinate target proteins"], "O96000": ["Respiratory electron transport", "Complex I biogenesis"], "O96006": ["SUMOylation of chromatin organization proteins"], "O96007": ["Molybdenum cofactor biosynthesis"], "O96008": ["Mitochondrial protein import", "Pink/Parkin Mediated Mitophagy"], "O96009": ["Surfactant metabolism"], "O96013": ["Activation of RAC1"], "O96014": ["WNT ligand biogenesis and trafficking", "WNT ligand biogenesis and trafficking", "Class B/2 (Secretin family receptors)", "Ca2+ pathway", "Ca2+ pathway", "PCP/CE pathway", "PCP/CE pathway"], "O96015": ["Retrograde neurotrophin signalling"], "O96017": ["Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Regulation of TP53 Activity through Phosphorylation", "Regulation of TP53 Degradation", "Regulation of TP53 Activity through Methylation", "G2/M DNA damage checkpoint", "Stabilization of p53", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex"], "O96018": ["Neurexins and neuroligins"], "O96019": ["HATs acetylate histones", "RMTs methylate histone arginines", "UCH proteinases", "DNA Damage Recognition in GG-NER", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "O96020": ["G0 and Early G1", "SCF(Skp2)-mediated degradation of p27/p21", "DNA Damage/Telomere Stress Induced Senescence", "Association of TriC/CCT with target proteins during biosynthesis", "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "CDK-mediated phosphorylation and removal of Cdc6", "Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes", "Cyclin E associated events during G1/S transition ", "p53-Dependent G1 DNA Damage Response"], "O96028": ["PKMTs methylate histone lysines", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "G2/M DNA damage checkpoint"], "O96033": ["Molybdenum cofactor biosynthesis"], "P00156": ["Respiratory electron transport"], "P00167": ["Vitamin C (ascorbate) metabolism"], "P00325": ["Ethanol oxidation"], "P00326": ["RA biosynthesis pathway", "Ethanol oxidation"], "P00338": ["Pyruvate metabolism"], "P00352": ["RA biosynthesis pathway", "Fructose catabolism", "Ethanol oxidation"], "P00367": ["Transcriptional activation of mitochondrial biogenesis", "Amino acid synthesis and interconversion (transamination)"], "P00374": ["Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "Metabolism of folate and pterines", "Activation of E2F1 target genes at G1/S"], "P00387": ["Vitamin C (ascorbate) metabolism", "Phase I - Functionalization of compounds", "Neutrophil degranulation"], "P00390-1": ["Detoxification of Reactive Oxygen Species"], "P00390-2": ["Metabolism of ingested H2SeO4 and H2SeO3 into H2Se", "Detoxification of Reactive Oxygen Species", "Interconversion of nucleotide di- and triphosphates", "TP53 Regulates Metabolic Genes"], "P00395": ["TP53 Regulates Metabolic Genes", "Respiratory electron transport"], "P00403": ["TP53 Regulates Metabolic Genes", "Respiratory electron transport"], "P00414": ["TP53 Regulates Metabolic Genes", "Respiratory electron transport"], "P00439": ["Phenylketonuria", "Phenylalanine and tyrosine catabolism"], "P00441": ["Platelet degranulation ", "Detoxification of Reactive Oxygen Species", "Detoxification of Reactive Oxygen Species", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "P00450": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Metal ion SLC transporters", "Defective CP causes aceruloplasminemia (ACERULOP)", "Post-translational protein phosphorylation", "Iron uptake and transport"], "P00451": ["Platelet degranulation ", "Intrinsic Pathway of Fibrin Clot Formation", "Common Pathway of Fibrin Clot Formation", "COPII-mediated vesicle transport", "Cargo concentration in the ER"], "P00480": ["Mitochondrial protein import", "Mitochondrial protein import", "Urea cycle"], "P00488": ["Platelet degranulation ", "Common Pathway of Fibrin Clot Formation", "Interleukin-4 and Interleukin-13 signaling"], "P00491": ["Neutrophil degranulation", "Purine salvage", "Purine catabolism"], "P00492": ["Purine salvage"], "P00505": ["Degradation of cysteine and homocysteine", "Glyoxylate metabolism and glycine degradation", "Gluconeogenesis", "Amino acid synthesis and interconversion (transamination)"], "P00519": ["Regulation of actin dynamics for phagocytic cup formation", "CDO in myogenesis", "CDO in myogenesis", "Role of ABL in ROBO-SLIT signaling", "Role of ABL in ROBO-SLIT signaling", "RHO GTPases Activate WASPs and WAVEs", "HDR through Single Strand Annealing (SSA)", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Cyclin D associated events in G1", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "RUNX2 regulates osteoblast differentiation", "Factors involved in megakaryocyte development and platelet production"], "P00533": ["Signaling by ERBB2", "Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "Signaling by ERBB4", "SHC1 events in ERBB2 signaling", "SHC1 events in ERBB2 signaling", "PLCG1 events in ERBB2 signaling", "PIP3 activates AKT signaling", "Signaling by EGFR", "GRB2 events in EGFR signaling", "GAB1 signalosome", "SHC1 events in EGFR signaling", "EGFR downregulation", "GRB2 events in ERBB2 signaling", "PI3K events in ERBB2 signaling", "EGFR interacts with phospholipase C-gamma", "EGFR Transactivation by Gastrin", "Constitutive Signaling by Aberrant PI3K in Cancer", "Signal transduction by L1", "Constitutive Signaling by EGFRvIII", "Inhibition of Signaling by Overexpressed EGFR", "RAF/MAP kinase cascade", "ERBB2 Regulates Cell Motility", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "ERBB2 Activates PTK6 Signaling", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "PTK6 promotes HIF1A stabilization", "Downregulation of ERBB2 signaling", "TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "NOTCH3 Activation and Transmission of Signal to the Nucleus"], "P00558": ["Glycolysis", "Gluconeogenesis"], "P00568": ["Interconversion of nucleotide di- and triphosphates"], "P00588": ["Uptake and function of diphtheria toxin"], "P00709": ["Lactose synthesis"], "P00734": ["Intrinsic Pathway of Fibrin Clot Formation", "Common Pathway of Fibrin Clot Formation", "Gamma-carboxylation of protein precursors", "Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "Removal of aminoterminal propeptides from gamma-carboxylated proteins", "Cell surface interactions at the vascular wall", "Peptide ligand-binding receptors", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "G alpha (q) signalling events", "Thrombin signalling through proteinase activated receptors (PARs)", "Platelet Aggregation (Plug Formation)", "Regulation of Complement cascade"], "P00736": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Regulation of Complement cascade"], "P00738": ["Scavenging of heme from plasma", "Neutrophil degranulation"], "P00739": ["Scavenging of heme from plasma"], "P00740": ["Extrinsic Pathway of Fibrin Clot Formation", "Intrinsic Pathway of Fibrin Clot Formation", "Gamma-carboxylation of protein precursors", "Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "Removal of aminoterminal propeptides from gamma-carboxylated proteins"], "P00742": ["Extrinsic Pathway of Fibrin Clot Formation", "Intrinsic Pathway of Fibrin Clot Formation", "Common Pathway of Fibrin Clot Formation", "Gamma-carboxylation of protein precursors", "Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "Removal of aminoterminal propeptides from gamma-carboxylated proteins"], "P00746": ["Platelet degranulation ", "Alternative complement activation", "Neutrophil degranulation"], "P00747": ["Platelet degranulation ", "Degradation of the extracellular matrix", "Degradation of the extracellular matrix", "Activation of Matrix Metalloproteinases", "Signaling by PDGF", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Dissolution of Fibrin Clot"], "P00748": ["Intrinsic Pathway of Fibrin Clot Formation"], "P00749": ["Neutrophil degranulation", "Dissolution of Fibrin Clot"], "P00750": ["Signaling by PDGF", "Dissolution of Fibrin Clot"], "P00751": ["Alternative complement activation", "Activation of C3 and C5", "Regulation of Complement cascade"], "P00797": ["Metabolism of Angiotensinogen to Angiotensins"], "P00813": ["Purine salvage"], "P00846": ["Formation of ATP by chemiosmotic coupling", "Cristae formation"], "P00915": ["Erythrocytes take up carbon dioxide and release oxygen", "Erythrocytes take up oxygen and release carbon dioxide", "Reversible hydration of carbon dioxide", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "P00918": ["Erythrocytes take up carbon dioxide and release oxygen", "Erythrocytes take up oxygen and release carbon dioxide", "Reversible hydration of carbon dioxide"], "P00966": ["Urea cycle"], "P00973": ["Interferon gamma signaling", "OAS antiviral response", "Interferon alpha/beta signaling"], "P01008": ["Intrinsic Pathway of Fibrin Clot Formation", "Common Pathway of Fibrin Clot Formation", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "P01009": ["Platelet degranulation ", "COPII-mediated vesicle transport", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Cargo concentration in the ER", "Neutrophil degranulation", "Post-translational protein phosphorylation"], "P01011": ["Platelet degranulation ", "Neutrophil degranulation"], "P01019": ["PPARA activates gene expression", "Metabolism of Angiotensinogen to Angiotensins", "Metabolism of Angiotensinogen to Angiotensins", "Peptide ligand-binding receptors", "G alpha (q) signalling events", "G alpha (i) signalling events"], "P01023": ["Platelet degranulation ", "Intrinsic Pathway of Fibrin Clot Formation", "Degradation of the extracellular matrix", "Rho GTPase cycle", "HDL assembly"], "P01024": ["Alternative complement activation", "Activation of C3 and C5", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Peptide ligand-binding receptors", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "G alpha (i) signalling events", "Neutrophil degranulation", "Post-translational protein phosphorylation", "Regulation of Complement cascade"], "P01031": ["Terminal pathway of complement", "Activation of C3 and C5", "Peptide ligand-binding receptors", "G alpha (i) signalling events", "Regulation of Complement cascade"], "P01033": ["Platelet degranulation ", "Activation of Matrix Metalloproteinases", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Interleukin-10 signaling", "Interleukin-4 and Interleukin-13 signaling", "Post-translational protein phosphorylation"], "P01034": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Neutrophil degranulation", "Post-translational protein phosphorylation", "Amyloid fiber formation"], "P01040": ["Formation of the cornified envelope"], "P01042": ["Platelet degranulation ", "Intrinsic Pathway of Fibrin Clot Formation", "Peptide ligand-binding receptors", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "G alpha (q) signalling events", "G alpha (i) signalling events", "Post-translational protein phosphorylation"], "P01100": ["Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "FCERI mediated MAPK activation", "Activation of the AP-1 family of transcription factors", "Interleukin-4 and Interleukin-13 signaling", "TP53 Regulates Transcription of DNA Repair Genes", "Estrogen-dependent gene expression"], "P01106": ["Transcription of E2F targets under negative control by DREAM complex", "NOTCH1 Intracellular Domain Regulates Transcription", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "Binding of TCF/LEF:CTNNB1 to target gene promoters", "MAPK6/MAPK4 signaling", "Ub-specific processing proteases", "Interleukin-4 and Interleukin-13 signaling", "Cyclin E associated events during G1/S transition ", "Cyclin A:Cdk2-associated events at S phase entry", "TFAP2 (AP-2) family regulates transcription of cell cycle factors", "RUNX3 regulates WNT signaling", "Estrogen-dependent gene expression"], "P01111": ["SOS-mediated signalling", "Activation of RAS in B cells", "Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "SHC1 events in ERBB2 signaling", "SHC1 events in ERBB4 signaling", "Signaling by SCF-KIT", "Signalling to RAS", "p38MAPK events", "p38MAPK events", "GRB2 events in EGFR signaling", "SHC1 events in EGFR signaling", "Downstream signal transduction", "GRB2 events in ERBB2 signaling", "GRB2 events in ERBB2 signaling", "Tie2 Signaling", "EGFR Transactivation by Gastrin", "DAP12 signaling", "SHC-related events triggered by IGF1R", "FCERI mediated MAPK activation", "NCAM signaling for neurite out-growth", "Ras activation upon Ca2+ influx through NMDA receptor", "VEGFR2 mediated cell proliferation", "CD209 (DC-SIGN) signaling", "Constitutive Signaling by EGFRvIII", "SHC-mediated cascade:FGFR1", "FRS-mediated FGFR1 signaling", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "Signaling by FGFR2 in disease", "Signaling by FGFR4 in disease", "Signaling by FGFR1 in disease", "Regulation of RAS by GAPs", "RAF activation", "RAF/MAP kinase cascade", "MAP2K and MAPK activation", "Negative regulation of MAPK pathway", "Neutrophil degranulation", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "RAS signaling downstream of NF1 loss-of-function variants", "Paradoxical activation of RAF signaling by kinase inactive BRAF", "Insulin receptor signalling cascade", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "MET activates RAS signaling", "Signaling by FGFR3 fusions in cancer", "Signaling by FGFR3 point mutants in cancer", "Activated NTRK2 signals through RAS", "Erythropoietin activates RAS", "Activated NTRK2 signals through FRS2 and FRS3", "Activated NTRK3 signals through RAS"], "P01112": ["SOS-mediated signalling", "Activation of RAS in B cells", "Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "SHC1 events in ERBB2 signaling", "SHC1 events in ERBB4 signaling", "Signaling by SCF-KIT", "Signalling to RAS", "p38MAPK events", "p38MAPK events", "GRB2 events in EGFR signaling", "SHC1 events in EGFR signaling", "Downstream signal transduction", "GRB2 events in ERBB2 signaling", "GRB2 events in ERBB2 signaling", "Tie2 Signaling", "EGFR Transactivation by Gastrin", "DAP12 signaling", "SHC-related events triggered by IGF1R", "FCERI mediated MAPK activation", "NCAM signaling for neurite out-growth", "EPHB-mediated forward signaling", "Ras activation upon Ca2+ influx through NMDA receptor", "VEGFR2 mediated cell proliferation", "CD209 (DC-SIGN) signaling", "Constitutive Signaling by EGFRvIII", "SHC-mediated cascade:FGFR1", "FRS-mediated FGFR1 signaling", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "Signaling by FGFR2 in disease", "Signaling by FGFR4 in disease", "Signaling by FGFR1 in disease", "Regulation of RAS by GAPs", "RAF activation", "RAF/MAP kinase cascade", "MAP2K and MAPK activation", "Negative regulation of MAPK pathway", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "RAS signaling downstream of NF1 loss-of-function variants", "Paradoxical activation of RAF signaling by kinase inactive BRAF", "Insulin receptor signalling cascade", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "MET activates RAS signaling", "Signaling by FGFR3 fusions in cancer", "Signaling by FGFR3 point mutants in cancer", "Activated NTRK2 signals through RAS", "Erythropoietin activates RAS", "Activated NTRK2 signals through FRS2 and FRS3", "Activated NTRK3 signals through RAS"], "P01116": ["SOS-mediated signalling", "Activation of RAS in B cells", "Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "SHC1 events in ERBB2 signaling", "SHC1 events in ERBB4 signaling", "Signaling by SCF-KIT", "Signalling to RAS", "p38MAPK events", "p38MAPK events", "GRB2 events in EGFR signaling", "SHC1 events in EGFR signaling", "Downstream signal transduction", "GRB2 events in ERBB2 signaling", "GRB2 events in ERBB2 signaling", "Tie2 Signaling", "EGFR Transactivation by Gastrin", "DAP12 signaling", "SHC-related events triggered by IGF1R", "FCERI mediated MAPK activation", "NCAM signaling for neurite out-growth", "Ras activation upon Ca2+ influx through NMDA receptor", "VEGFR2 mediated cell proliferation", "CD209 (DC-SIGN) signaling", "Constitutive Signaling by EGFRvIII", "SHC-mediated cascade:FGFR1", "FRS-mediated FGFR1 signaling", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "Signaling by FGFR2 in disease", "Signaling by FGFR4 in disease", "Signaling by FGFR1 in disease", "Regulation of RAS by GAPs", "RAF activation", "RAF/MAP kinase cascade", "MAP2K and MAPK activation", "Negative regulation of MAPK pathway", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "RAS signaling downstream of NF1 loss-of-function variants", "Paradoxical activation of RAF signaling by kinase inactive BRAF", "Insulin receptor signalling cascade", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "MET activates RAS signaling", "Signaling by FGFR3 fusions in cancer", "Signaling by FGFR3 point mutants in cancer", "RUNX3 regulates p14-ARF", "Activated NTRK2 signals through RAS", "Erythropoietin activates RAS", "Activated NTRK2 signals through FRS2 and FRS3", "Activated NTRK3 signals through RAS"], "P01127": ["Platelet degranulation ", "PIP3 activates AKT signaling", "Downstream signal transduction", "Signaling by PDGF", "Constitutive Signaling by Aberrant PI3K in Cancer", "Non-integrin membrane-ECM interactions", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "P01130": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "Chylomicron clearance", "Chylomicron clearance", "LDL clearance", "Retinoid metabolism and transport"], "P01133": ["Platelet degranulation ", "Signaling by ERBB2", "Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "Signaling by ERBB4", "SHC1 events in ERBB2 signaling", "SHC1 events in ERBB2 signaling", "PLCG1 events in ERBB2 signaling", "PIP3 activates AKT signaling", "Signaling by EGFR", "Signaling by EGFR", "GRB2 events in EGFR signaling", "GAB1 signalosome", "SHC1 events in EGFR signaling", "EGFR downregulation", "GRB2 events in ERBB2 signaling", "PI3K events in ERBB2 signaling", "EGFR interacts with phospholipase C-gamma", "Constitutive Signaling by Aberrant PI3K in Cancer", "Constitutive Signaling by EGFRvIII", "Inhibition of Signaling by Overexpressed EGFR", "RAF/MAP kinase cascade", "ERBB2 Regulates Cell Motility", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "ERBB2 Activates PTK6 Signaling", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "Downregulation of ERBB2 signaling", "NOTCH3 Activation and Transmission of Signal to the Nucleus"], "P01135": ["PIP3 activates AKT signaling", "Signaling by EGFR", "GRB2 events in EGFR signaling", "GAB1 signalosome", "SHC1 events in EGFR signaling", "EGFR downregulation", "COPII-mediated vesicle transport", "EGFR interacts with phospholipase C-gamma", "Constitutive Signaling by Aberrant PI3K in Cancer", "Inhibition of Signaling by Overexpressed EGFR", "RAF/MAP kinase cascade", "Cargo concentration in the ER", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "Estrogen-dependent gene expression"], "P01137": ["Platelet degranulation ", "Influenza Virus Induced Apoptosis", "Cell surface interactions at the vascular wall", "Molecules associated with elastic fibres", "Downregulation of TGF-beta receptor signaling", "Downregulation of TGF-beta receptor signaling", "TGF-beta receptor signaling activates SMADs", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "Syndecan interactions", "ECM proteoglycans", "SMAD2/3 Phosphorylation Motif Mutants in Cancer", "SMAD2/3 MH2 Domain Mutants in Cancer", "TGFBR2 MSI Frameshift Mutants in Cancer", "TGFBR2 Kinase Domain Mutants in Cancer", "TGFBR1 KD Mutants in Cancer", "TGFBR1 LBD Mutants in Cancer", "Transcriptional regulation of white adipocyte differentiation", "UCH proteinases", "Interleukin-4 and Interleukin-13 signaling", "RUNX3 regulates CDKN1A transcription", "Regulation of RUNX3 expression and activity", "RUNX3 regulates p14-ARF"], "P01138": ["PLC-gamma1 signalling", "Signalling to RAS", "NGF processing", "NGF processing", "Frs2-mediated activation", "Frs2-mediated activation", "ARMS-mediated activation", "ARMS-mediated activation", "Retrograde neurotrophin signalling", "Retrograde neurotrophin signalling", "TRKA activation by NGF", "TRKA activation by NGF", "Signalling to p38 via RIT and RIN", "NRAGE signals death through JNK", "p75NTR negatively regulates cell cycle via SC1", "Ceramide signalling", "PI3K/AKT activation", "PI3K/AKT activation", "Signalling to STAT3", "NFG and proNGF binds to p75NTR", "NADE modulates death signalling", "NRIF signals cell death from the nucleus", "NRIF signals cell death from the nucleus", "p75NTR recruits signalling complexes", "p75NTR recruits signalling complexes", "NF-kB is activated and signals survival", "Axonal growth stimulation"], "P01148": ["Hormone ligand-binding receptors", "G alpha (q) signalling events"], "P01160": ["YAP1- and WWTR1 (TAZ)-stimulated gene expression", "Physiological factors", "Amyloid fiber formation"], "P01178": ["Vasopressin-like receptors", "G alpha (q) signalling events"], "P01185": ["BMAL1:CLOCK,NPAS2 activates circadian gene expression", "Vasopressin-like receptors", "G alpha (q) signalling events", "G alpha (s) signalling events", "Vasopressin regulates renal water homeostasis via Aquaporins", "Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI)", "Transport of organic anions", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI)"], "P01189": ["Opioid Signalling", "Androgen biosynthesis", "Glucocorticoid biosynthesis", "G-protein activation", "Peptide hormone biosynthesis", "Endogenous sterols", "Peptide ligand-binding receptors", "G alpha (s) signalling events", "G alpha (i) signalling events", "Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)", "Interleukin-4 and Interleukin-13 signaling", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes"], "P01210": ["Peptide ligand-binding receptors", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "G alpha (i) signalling events", "Post-translational protein phosphorylation"], "P01213": ["Opioid Signalling", "G-protein activation", "Peptide ligand-binding receptors", "G alpha (i) signalling events"], "P01215": ["Androgen biosynthesis", "Mineralocorticoid biosynthesis", "Glycoprotein hormones", "Thyroxine biosynthesis", "Hormone ligand-binding receptors", "G alpha (s) signalling events", "TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "Reactions specific to the complex N-glycan synthesis pathway"], "P01222": ["Glycoprotein hormones", "Thyroxine biosynthesis", "Hormone ligand-binding receptors", "G alpha (s) signalling events"], "P01225": ["Glycoprotein hormones", "Hormone ligand-binding receptors", "G alpha (s) signalling events"], "P01229": ["Androgen biosynthesis", "Mineralocorticoid biosynthesis", "Glycoprotein hormones", "Hormone ligand-binding receptors", "G alpha (s) signalling events", "Reactions specific to the complex N-glycan synthesis pathway"], "P01236": ["Prolactin receptor signaling", "Prolactin receptor signaling", "Amyloid fiber formation", "Growth hormone receptor signaling"], "P01241": ["Prolactin receptor signaling", "Prolactin receptor signaling", "Synthesis, secretion, and deacylation of Ghrelin", "Growth hormone receptor signaling", "Growth hormone receptor signaling"], "P01242": ["Prolactin receptor signaling", "Prolactin receptor signaling", "Growth hormone receptor signaling", "Growth hormone receptor signaling"], "P01258": ["G alpha (s) signalling events", "Calcitonin-like ligand receptors", "Amyloid fiber formation"], "P01270": ["Class B/2 (Secretin family receptors)", "G alpha (s) signalling events"], "P01275": ["Glucagon signaling in metabolic regulation", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "G alpha (q) signalling events", "G alpha (s) signalling events", "Glucagon-type ligand receptors", "Synthesis, secretion, and deacylation of Ghrelin"], "P01282": ["G alpha (s) signalling events", "Glucagon-type ligand receptors"], "P01286": ["G alpha (s) signalling events", "Glucagon-type ligand receptors"], "P01298": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "P01303": ["Peptide ligand-binding receptors", "G alpha (i) signalling events", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes"], "P01308": ["Regulation of gene expression in beta cells", "Insulin processing", "Insulin processing", "Synthesis, secretion, and deacylation of Ghrelin", "Regulation of insulin secretion", "COPI-mediated anterograde transport", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "IRS activation", "Signal attenuation", "Insulin receptor signalling cascade", "Signaling by Insulin receptor", "Insulin receptor recycling", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "Amyloid fiber formation"], "P01344": ["Platelet degranulation ", "Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "IRS-related events triggered by IGF1R", "SHC-related events triggered by IGF1R", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "P01350": ["G alpha (q) signalling events", "Gastrin-CREB signalling pathway via PKC and MAPK"], "P01374": ["TNFR2 non-canonical NF-kB pathway", "TNFs bind their physiological receptors", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "P01375": ["Transcriptional regulation of white adipocyte differentiation", "TNFR1-induced proapoptotic signaling", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "TNFR1-mediated ceramide production", "TNFR2 non-canonical NF-kB pathway", "Interleukin-10 signaling", "Interleukin-4 and Interleukin-13 signaling", "TNF signaling"], "P01559": ["Intestinal infectious diseases"], "P01562": ["Interferon alpha/beta signaling", "Regulation of IFNA signaling", "Regulation of IFNA signaling", "TRAF6 mediated IRF7 activation", "Factors involved in megakaryocyte development and platelet production"], "P01563": ["Interferon alpha/beta signaling", "Regulation of IFNA signaling", "Regulation of IFNA signaling", "TRAF6 mediated IRF7 activation", "Factors involved in megakaryocyte development and platelet production"], "P01566": ["Interferon alpha/beta signaling", "Regulation of IFNA signaling", "Regulation of IFNA signaling", "TRAF6 mediated IRF7 activation", "Factors involved in megakaryocyte development and platelet production"], "P01567": ["Interferon alpha/beta signaling", "Regulation of IFNA signaling", "Regulation of IFNA signaling", "TRAF6 mediated IRF7 activation", "Factors involved in megakaryocyte development and platelet production"], "P01568": ["Interferon alpha/beta signaling", "Regulation of IFNA signaling", "Regulation of IFNA signaling", "TRAF6 mediated IRF7 activation", "Factors involved in megakaryocyte development and platelet production"], "P01569": ["Interferon alpha/beta signaling", "Regulation of IFNA signaling", "Regulation of IFNA signaling", "TRAF6 mediated IRF7 activation", "Factors involved in megakaryocyte development and platelet production"], "P01570": ["Interferon alpha/beta signaling", "Regulation of IFNA signaling", "Regulation of IFNA signaling", "TRAF6 mediated IRF7 activation", "Factors involved in megakaryocyte development and platelet production"], "P01571": ["Interferon alpha/beta signaling", "Regulation of IFNA signaling", "Regulation of IFNA signaling", "TRAF6 mediated IRF7 activation", "Factors involved in megakaryocyte development and platelet production"], "P01574": ["Oxidative Stress Induced Senescence", "Interferon alpha/beta signaling", "Regulation of IFNA signaling", "Regulation of IFNA signaling", "TRAF3-dependent IRF activation pathway", "TRAF6 mediated IRF7 activation", "Factors involved in megakaryocyte development and platelet production"], "P01579": ["Interferon gamma signaling", "Regulation of IFNG signaling", "Regulation of IFNG signaling", "RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "P01583": ["Senescence-Associated Secretory Phenotype (SASP)", "Interleukin-1 processing", "Interleukin-10 signaling", "Interleukin-4 and Interleukin-13 signaling", "Interleukin-1 signaling"], "P01584": ["Interleukin-1 processing", "CLEC7A/inflammasome pathway", "Interleukin-10 signaling", "Interleukin-4 and Interleukin-13 signaling", "Interleukin-1 signaling"], "P01588": ["Regulation of gene expression by Hypoxia-inducible Factor", "Signaling by Erythropoietin", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "Erythropoietin activates Phospholipase C gamma (PLCG)", "Erythropoietin activates STAT5", "Erythropoietin activates RAS", "Erythropoietin activates RAS"], "P01589": ["RAF/MAP kinase cascade", "RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "Interleukin-2 signaling", "Interleukin receptor SHC signaling"], "P01591": ["Cell surface interactions at the vascular wall", "Scavenging of heme from plasma"], "P01593": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P01594": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P01597": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P01599": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P01601": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P01602": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P01611": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P01614": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P01615": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P01619": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P01624": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P01699": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P01700": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P01701": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P01703": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P01704": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P01705": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P01706": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P01709": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P01714": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P01715": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P01717": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P01718": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P01721": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P01730": ["Alpha-defensins", "Nef Mediated CD4 Down-regulation", "Binding and entry of HIV virion", "Vpu mediated degradation of CD4", "Downstream TCR signaling", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "PD-1 signaling", "Other interleukin signaling", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "P01732": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "P01733": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Downstream TCR signaling", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "PD-1 signaling"], "P01737": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Downstream TCR signaling", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "PD-1 signaling"], "P01742": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P01743": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P01762": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P01763": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P01764": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P01766": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P01767": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P01768": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P01772": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P01780": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P01782": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P01814": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P01817": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P01824": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P01825": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P01833": ["Neutrophil degranulation"], "P01834": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P01848": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Downstream TCR signaling", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "PD-1 signaling"], "P01850": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Downstream TCR signaling", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "PD-1 signaling"], "P01854": ["Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "Interleukin-4 and Interleukin-13 signaling"], "P01857": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Interleukin-4 and Interleukin-13 signaling", "Regulation of Complement cascade"], "P01859": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Regulation of Complement cascade"], "P01860": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Regulation of Complement cascade"], "P01861": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Interleukin-4 and Interleukin-13 signaling", "Regulation of Complement cascade"], "P01871": ["Cell surface interactions at the vascular wall", "CD22 mediated BCR regulation", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P01876": ["Cell surface interactions at the vascular wall", "Scavenging of heme from plasma"], "P01877": ["Cell surface interactions at the vascular wall", "Scavenging of heme from plasma"], "P01880": ["CD22 mediated BCR regulation", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P01889": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P01891": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P01892": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Nef mediated downregulation of MHC class I complex cell surface expression", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "E3 ubiquitin ligases ubiquitinate target proteins", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P01893": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P01903": ["Downstream TCR signaling", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "MHC class II antigen presentation", "PD-1 signaling", "Interferon gamma signaling"], "P01906": ["Downstream TCR signaling", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "MHC class II antigen presentation", "PD-1 signaling", "Interferon gamma signaling"], "P01909": ["Downstream TCR signaling", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "MHC class II antigen presentation", "PD-1 signaling", "Interferon gamma signaling"], "P01911": ["Downstream TCR signaling", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "MHC class II antigen presentation", "PD-1 signaling", "Interferon gamma signaling"], "P01912": ["Downstream TCR signaling", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "MHC class II antigen presentation", "PD-1 signaling", "Interferon gamma signaling"], "P01920": ["Downstream TCR signaling", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "MHC class II antigen presentation", "PD-1 signaling", "Interferon gamma signaling"], "P02042": ["Factors involved in megakaryocyte development and platelet production"], "P02100": ["Factors involved in megakaryocyte development and platelet production"], "P02144": ["Intracellular oxygen transport"], "P02452": ["GPVI-mediated activation cascade", "Collagen degradation", "Collagen degradation", "Extracellular matrix organization", "Collagen biosynthesis and modifying enzymes", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Assembly of collagen fibrils and other multimeric structures", "Cell surface interactions at the vascular wall", "Integrin cell surface interactions", "Integrin cell surface interactions", "Anchoring fibril formation", "Crosslinking of collagen fibrils", "Syndecan interactions", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "ECM proteoglycans", "Scavenging by Class A Receptors", "GP1b-IX-V activation signalling", "Platelet Adhesion to exposed collagen", "Platelet Adhesion to exposed collagen", "Platelet Aggregation (Plug Formation)", "MET activates PTK2 signaling", "RUNX2 regulates osteoblast differentiation", "Collagen chain trimerization"], "P02458": ["Collagen degradation", "Collagen degradation", "Extracellular matrix organization", "Collagen biosynthesis and modifying enzymes", "Signaling by PDGF", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "Integrin cell surface interactions", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "ECM proteoglycans", "NCAM1 interactions", "MET activates PTK2 signaling", "Collagen chain trimerization"], "P02461": ["Collagen degradation", "Collagen degradation", "Extracellular matrix organization", "Collagen biosynthesis and modifying enzymes", "Signaling by PDGF", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "Syndecan interactions", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "ECM proteoglycans", "Scavenging by Class A Receptors", "NCAM1 interactions", "MET activates PTK2 signaling", "Collagen chain trimerization"], "P02462": ["Collagen degradation", "Collagen degradation", "Extracellular matrix organization", "Collagen biosynthesis and modifying enzymes", "Signaling by PDGF", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "Integrin cell surface interactions", "Anchoring fibril formation", "Crosslinking of collagen fibrils", "Laminin interactions", "Laminin interactions", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "Scavenging by Class A Receptors", "NCAM1 interactions", "Collagen chain trimerization"], "P02511": ["HSF1-dependent transactivation"], "P02533": ["Type I hemidesmosome assembly", "Keratinization", "Formation of the cornified envelope"], "P02538": ["Keratinization", "Formation of the cornified envelope"], "P02545": ["XBP1(S) activates chaperone genes", "Signaling by BRAF and RAF fusions"], "P02545-1": ["Clearance of Nuclear Envelope Membranes from Chromatin", "Initiation of Nuclear Envelope Reformation", "Breakdown of the nuclear lamina", "Depolymerisation of the Nuclear Lamina", "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models"], "P02545-2": ["Meiotic synapsis", "Clearance of Nuclear Envelope Membranes from Chromatin", "Initiation of Nuclear Envelope Reformation", "Depolymerisation of the Nuclear Lamina"], "P02549": ["NCAM signaling for neurite out-growth", "NCAM signaling for neurite out-growth", "Interaction between L1 and Ankyrins", "Interaction between L1 and Ankyrins", "RAF/MAP kinase cascade", "COPI-mediated anterograde transport"], "P02585": ["Striated Muscle Contraction"], "P02647": ["Platelet degranulation ", "ABC transporters in lipid homeostasis", "PPARA activates gene expression", "Scavenging of heme from plasma", "Scavenging by Class B Receptors", "Scavenging by Class B Receptors", "Scavenging by Class A Receptors", "Scavenging by Class A Receptors", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation", "Chylomicron assembly", "HDL assembly", "Chylomicron remodeling", "HDL clearance", "HDL remodeling", "Retinoid metabolism and transport", "Retinoid metabolism and transport", "Amyloid fiber formation"], "P02649": ["Scavenging by Class A Receptors", "Scavenging by Class A Receptors", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors", "Post-translational protein phosphorylation", "Chylomicron assembly", "Chylomicron remodeling", "Chylomicron clearance", "Chylomicron clearance", "HDL remodeling", "Retinoid metabolism and transport", "Retinoid metabolism and transport"], "P02652": ["PPARA activates gene expression", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation", "Chylomicron assembly", "Chylomicron remodeling", "Retinoid metabolism and transport", "Retinoid metabolism and transport"], "P02654": ["VLDL assembly", "VLDL clearance", "VLDL clearance"], "P02655": ["Chylomicron assembly", "Assembly of active LPL and LIPC lipase complexes", "Chylomicron remodeling", "HDL remodeling", "Retinoid metabolism and transport", "Retinoid metabolism and transport"], "P02656": ["Chylomicron assembly", "Chylomicron remodeling", "HDL remodeling", "Retinoid metabolism and transport", "Retinoid metabolism and transport"], "P02671": ["Platelet degranulation ", "Common Pathway of Fibrin Clot Formation", "Integrin cell surface interactions", "Integrin alphaIIb beta3 signaling", "GRB2:SOS provides linkage to MAPK signaling for Integrins ", "p130Cas linkage to MAPK signaling for integrins", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "MAP2K and MAPK activation", "Regulation of TLR by endogenous ligand", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF", "Post-translational protein phosphorylation", "Amyloid fiber formation"], "P02675": ["Platelet degranulation ", "Common Pathway of Fibrin Clot Formation", "Integrin cell surface interactions", "Integrin alphaIIb beta3 signaling", "GRB2:SOS provides linkage to MAPK signaling for Integrins ", "p130Cas linkage to MAPK signaling for integrins", "MAP2K and MAPK activation", "Regulation of TLR by endogenous ligand", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF"], "P02679": ["Platelet degranulation ", "Common Pathway of Fibrin Clot Formation", "Integrin cell surface interactions", "Integrin alphaIIb beta3 signaling", "GRB2:SOS provides linkage to MAPK signaling for Integrins ", "p130Cas linkage to MAPK signaling for integrins", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "MAP2K and MAPK activation", "Regulation of TLR by endogenous ligand", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF", "Post-translational protein phosphorylation"], "P02708": ["Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "Highly calcium permeable nicotinic acetylcholine receptors"], "P02724": ["Cell surface interactions at the vascular wall"], "P02730": ["Erythrocytes take up carbon dioxide and release oxygen", "Erythrocytes take up oxygen and release carbon dioxide", "Bicarbonate transporters", "Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)"], "P02741": ["Classical antibody-mediated complement activation"], "P02743": ["Amyloid fiber formation"], "P02745": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Regulation of Complement cascade"], "P02746": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Regulation of Complement cascade"], "P02747": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Regulation of Complement cascade"], "P02748": ["Terminal pathway of complement", "Regulation of Complement cascade"], "P02749": ["Platelet degranulation "], "P02750": ["Neutrophil degranulation"], "P02751": ["Platelet degranulation ", "Degradation of the extracellular matrix", "Degradation of the extracellular matrix", "Extracellular matrix organization", "Fibronectin matrix formation", "Cell surface interactions at the vascular wall", "Molecules associated with elastic fibres", "Integrin cell surface interactions", "Syndecan interactions", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "Integrin alphaIIb beta3 signaling", "GRB2:SOS provides linkage to MAPK signaling for Integrins ", "p130Cas linkage to MAPK signaling for integrins", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "MAP2K and MAPK activation", "Interleukin-4 and Interleukin-13 signaling", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF", "MET activates PTK2 signaling", "Post-translational protein phosphorylation"], "P02753": ["Retinoid cycle disease events", "The canonical retinoid cycle in rods (twilight vision)", "Retinoid metabolism disease events", "Retinoid metabolism and transport"], "P02760": ["Scavenging of heme from plasma"], "P02763": ["Platelet degranulation ", "Neutrophil degranulation"], "P02765": ["Platelet degranulation ", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Neutrophil degranulation", "Post-translational protein phosphorylation"], "P02766": ["Retinoid cycle disease events", "The canonical retinoid cycle in rods (twilight vision)", "Non-integrin membrane-ECM interactions", "Neutrophil degranulation", "Retinoid metabolism and transport", "Amyloid fiber formation"], "P02768": ["Platelet degranulation ", "Recycling of bile acids and salts", "Scavenging of heme from plasma", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR)", "Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)", "Transport of organic anions", "Post-translational protein phosphorylation", "HDL remodeling"], "P02771": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "P02774": ["Vitamin D (calciferol) metabolism"], "P02775": ["Platelet degranulation ", "Chemokine receptors bind chemokines", "G alpha (i) signalling events", "Neutrophil degranulation"], "P02776": ["Platelet degranulation ", "Common Pathway of Fibrin Clot Formation", "Cell surface interactions at the vascular wall", "Chemokine receptors bind chemokines", "G alpha (i) signalling events", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"], "P02778": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events", "Interleukin-10 signaling"], "P02786": ["Golgi Associated Vesicle Biogenesis", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "Transferrin endocytosis and recycling"], "P02787": ["Platelet degranulation ", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "Post-translational protein phosphorylation", "Iron uptake and transport", "Transferrin endocytosis and recycling"], "P02788": ["Mtb iron assimilation by chelation", "Neutrophil degranulation", "Metal sequestration by antimicrobial proteins", "Antimicrobial peptides", "Amyloid fiber formation"], "P02790": ["Scavenging of heme from plasma"], "P02792": ["Scavenging by Class A Receptors", "Golgi Associated Vesicle Biogenesis", "Neutrophil degranulation", "Iron uptake and transport"], "P02794": ["Scavenging by Class A Receptors", "Golgi Associated Vesicle Biogenesis", "Neutrophil degranulation", "Iron uptake and transport"], "P02795": ["Metallothioneins bind metals", "Metallothioneins bind metals", "Interferon gamma signaling"], "P02818": ["Gamma-carboxylation of protein precursors", "Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "Removal of aminoterminal propeptides from gamma-carboxylated proteins", "RUNX2 regulates osteoblast differentiation"], "P03372": ["Nuclear signaling by ERBB4", "PIP3 activates AKT signaling", "Constitutive Signaling by Aberrant PI3K in Cancer", "Nuclear Receptor transcription pathway", "SUMOylation of intracellular receptors", "Ovarian tumor domain proteases", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "RUNX1 regulates estrogen receptor mediated transcription", "ESR-mediated signaling", "RUNX1 regulates transcription of genes involved in WNT signaling", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Estrogen-dependent gene expression"], "P03372-3": ["PIP3 activates AKT signaling", "Constitutive Signaling by Aberrant PI3K in Cancer", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "P03372-4": ["PIP3 activates AKT signaling", "Constitutive Signaling by Aberrant PI3K in Cancer", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "P03375": ["Dectin-2 family"], "P03377": ["Dectin-2 family"], "P03378": ["Dectin-2 family"], "P03428": ["Influenza Life Cycle", "Transport of Ribonucleoproteins into the Host Nucleus", "Entry of Influenza Virion into Host Cell via Endocytosis", "Fusion of the Influenza Virion to the Host Cell Endosome", "Release", "Budding", "Packaging of Eight RNA Segments", "Viral Messenger RNA Synthesis", "Viral RNP Complexes in the Host Cell Nucleus", "NEP/NS2 Interacts with the Cellular Export Machinery", "Uncoating of the Influenza Virion", "vRNA Synthesis", "Viral mRNA Translation", "cRNA Synthesis", "vRNP Assembly"], "P03431": ["Influenza Life Cycle", "Transport of Ribonucleoproteins into the Host Nucleus", "Entry of Influenza Virion into Host Cell via Endocytosis", "Fusion of the Influenza Virion to the Host Cell Endosome", "Release", "Budding", "Packaging of Eight RNA Segments", "Viral Messenger RNA Synthesis", "Viral RNP Complexes in the Host Cell Nucleus", "NEP/NS2 Interacts with the Cellular Export Machinery", "Uncoating of the Influenza Virion", "vRNA Synthesis", "Viral mRNA Translation", "cRNA Synthesis", "vRNP Assembly"], "P03433": ["Influenza Life Cycle", "Transport of Ribonucleoproteins into the Host Nucleus", "Entry of Influenza Virion into Host Cell via Endocytosis", "Fusion of the Influenza Virion to the Host Cell Endosome", "Release", "Budding", "Packaging of Eight RNA Segments", "Viral Messenger RNA Synthesis", "Viral RNP Complexes in the Host Cell Nucleus", "NEP/NS2 Interacts with the Cellular Export Machinery", "Uncoating of the Influenza Virion", "vRNA Synthesis", "Viral mRNA Translation", "cRNA Synthesis", "vRNP Assembly"], "P03452": ["Influenza Life Cycle", "Entry of Influenza Virion into Host Cell via Endocytosis", "Fusion of the Influenza Virion to the Host Cell Endosome", "Release", "Budding", "Packaging of Eight RNA Segments", "Assembly of Viral Components at the Budding Site", "Uncoating of the Influenza Virion", "Transport of HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum to the Golgi Apparatus", "Viral mRNA Translation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "P03466": ["Influenza Life Cycle", "Transport of Ribonucleoproteins into the Host Nucleus", "Entry of Influenza Virion into Host Cell via Endocytosis", "Fusion of the Influenza Virion to the Host Cell Endosome", "Release", "Budding", "Packaging of Eight RNA Segments", "Assembly of Viral Components at the Budding Site", "Viral Messenger RNA Synthesis", "Viral RNP Complexes in the Host Cell Nucleus", "NEP/NS2 Interacts with the Cellular Export Machinery", "Uncoating of the Influenza Virion", "vRNA Synthesis", "Viral mRNA Translation", "cRNA Synthesis", "vRNP Assembly"], "P03468": ["Influenza Life Cycle", "Entry of Influenza Virion into Host Cell via Endocytosis", "Influenza Virus Induced Apoptosis", "Fusion of the Influenza Virion to the Host Cell Endosome", "Release", "Budding", "Packaging of Eight RNA Segments", "Assembly of Viral Components at the Budding Site", "Uncoating of the Influenza Virion", "Transport of HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum to the Golgi Apparatus", "Viral mRNA Translation"], "P03485": ["Influenza Life Cycle", "Entry of Influenza Virion into Host Cell via Endocytosis", "Fusion of the Influenza Virion to the Host Cell Endosome", "Release", "Budding", "Packaging of Eight RNA Segments", "Assembly of Viral Components at the Budding Site", "Viral RNP Complexes in the Host Cell Nucleus", "NEP/NS2 Interacts with the Cellular Export Machinery", "Uncoating of the Influenza Virion", "Viral mRNA Translation"], "P03496": ["ISG15 antiviral mechanism", "NS1 Mediated Effects on Host Pathways", "Inhibition of Host mRNA Processing and RNA Silencing", "Inhibition of IFN-beta", "Inhibition of PKR", "Viral mRNA Translation"], "P03508": ["Influenza Life Cycle", "Entry of Influenza Virion into Host Cell via Endocytosis", "Fusion of the Influenza Virion to the Host Cell Endosome", "Release", "Budding", "Packaging of Eight RNA Segments", "Viral RNP Complexes in the Host Cell Nucleus", "NEP/NS2 Interacts with the Cellular Export Machinery", "Uncoating of the Influenza Virion", "Viral mRNA Translation"], "P03886": ["Respiratory electron transport", "Complex I biogenesis"], "P03891": ["Respiratory electron transport", "Complex I biogenesis"], "P03897": ["Respiratory electron transport", "Complex I biogenesis"], "P03905": ["Respiratory electron transport", "Complex I biogenesis"], "P03915": ["Respiratory electron transport", "Complex I biogenesis"], "P03923": ["Respiratory electron transport", "Complex I biogenesis"], "P03928": ["Formation of ATP by chemiosmotic coupling", "Cristae formation"], "P03950": ["Adherens junctions interactions"], "P03951": ["Intrinsic Pathway of Fibrin Clot Formation"], "P03952": ["Intrinsic Pathway of Fibrin Clot Formation", "Activation of Matrix Metalloproteinases"], "P03956": ["Collagen degradation", "Collagen degradation", "Degradation of the extracellular matrix", "Degradation of the extracellular matrix", "Activation of Matrix Metalloproteinases", "Basigin interactions", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Interleukin-4 and Interleukin-13 signaling"], "P03971": ["Signaling by BMP"], "P03973": ["Neutrophil degranulation"], "P03989": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P03999": ["The retinoid cycle in cones (daylight vision)", "Retinoid cycle disease events", "G alpha (i) signalling events", "Opsins"], "P04000": ["The retinoid cycle in cones (daylight vision)", "Retinoid cycle disease events", "G alpha (i) signalling events", "Opsins"], "P04001": ["The retinoid cycle in cones (daylight vision)", "Retinoid cycle disease events", "G alpha (i) signalling events", "Opsins"], "P04003": ["Regulation of Complement cascade"], "P04004": ["Molecules associated with elastic fibres", "Integrin cell surface interactions", "Syndecan interactions", "ECM proteoglycans", "ECM proteoglycans", "Regulation of Complement cascade"], "P04035-1": ["Cholesterol biosynthesis", "PPARA activates gene expression", "Activation of gene expression by SREBF (SREBP)"], "P04035-2": ["Cholesterol biosynthesis"], "P04040": ["Detoxification of Reactive Oxygen Species", "Neutrophil degranulation", "Peroxisomal protein import", "Peroxisomal protein import", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes"], "P04049": ["Stimuli-sensing channels", "Rap1 signalling", "GP1b-IX-V activation signalling", "CD209 (DC-SIGN) signaling", "RAF activation", "MAP2K and MAPK activation", "Negative feedback regulation of MAPK pathway", "Negative regulation of MAPK pathway", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF"], "P04054": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PS", "Acyl chain remodelling of PE", "Acyl chain remodelling of PI", "Acyl chain remodelling of PG", "Synthesis of PA"], "P04062": ["Glycosphingolipid metabolism", "Association of TriC/CCT with target proteins during biosynthesis"], "P04066": ["Neutrophil degranulation", "Reactions specific to the complex N-glycan synthesis pathway"], "P04070": ["Intrinsic Pathway of Fibrin Clot Formation", "Common Pathway of Fibrin Clot Formation", "Gamma-carboxylation of protein precursors", "Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "Removal of aminoterminal propeptides from gamma-carboxylated proteins", "Cell surface interactions at the vascular wall", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "P04075": ["Platelet degranulation ", "Neutrophil degranulation", "Glycolysis", "Gluconeogenesis"], "P04080": ["Neutrophil degranulation"], "P04083": ["G alpha (q) signalling events", "G alpha (i) signalling events", "Formyl peptide receptors bind formyl peptides and many other ligands", "Smooth Muscle Contraction", "Interleukin-4 and Interleukin-13 signaling"], "P04085": ["Non-integrin membrane-ECM interactions"], "P04085-1": ["Platelet degranulation ", "PIP3 activates AKT signaling", "Downstream signal transduction", "Signaling by PDGF", "Constitutive Signaling by Aberrant PI3K in Cancer", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "P04085-2": ["PIP3 activates AKT signaling", "Downstream signal transduction", "Signaling by PDGF", "Constitutive Signaling by Aberrant PI3K in Cancer", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "P04090": ["G alpha (s) signalling events", "Relaxin receptors"], "P04114": ["Cell surface interactions at the vascular wall", "Scavenging by Class B Receptors", "Scavenging by Class B Receptors", "Scavenging by Class A Receptors", "Scavenging by Class A Receptors", "Scavenging by Class F Receptors", "Scavenging by Class F Receptors", "Scavenging by Class H Receptors", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Platelet sensitization by LDL", "Regulation of TLR by endogenous ligand", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "VLDL assembly", "Post-translational protein phosphorylation", "Chylomicron assembly", "Chylomicron remodeling", "Chylomicron clearance", "Chylomicron clearance", "LDL clearance", "LDL clearance", "LDL remodeling", "VLDL clearance", "VLDL clearance", "Retinoid metabolism and transport", "Retinoid metabolism and transport"], "P04118": ["Digestion of dietary lipid", "Retinoid metabolism and transport"], "P04141": ["Interleukin-3, Interleukin-5 and GM-CSF signaling", "RAF/MAP kinase cascade", "Interleukin-10 signaling", "RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "Interleukin receptor SHC signaling"], "P04150": ["HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Circadian Clock", "SUMOylation of intracellular receptors", "PTK6 Expression", "Regulation of RUNX2 expression and activity", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes"], "P04150-1": ["Nuclear Receptor transcription pathway"], "P04150-2": ["Nuclear Receptor transcription pathway"], "P04150-3": ["Nuclear Receptor transcription pathway"], "P04150-4": ["Nuclear Receptor transcription pathway"], "P04150-5": ["Nuclear Receptor transcription pathway"], "P04150-6": ["Nuclear Receptor transcription pathway"], "P04150-7": ["Nuclear Receptor transcription pathway"], "P04150-8": ["Nuclear Receptor transcription pathway"], "P04150-9": ["Nuclear Receptor transcription pathway"], "P04155": ["Estrogen-dependent gene expression"], "P04156": ["NCAM1 interactions"], "P04179": ["Transcriptional activation of mitochondrial biogenesis", "Detoxification of Reactive Oxygen Species", "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes"], "P04180": ["HDL remodeling"], "P04181": ["Amino acid synthesis and interconversion (transamination)"], "P04183": ["Activation of E2F1 target genes at G1/S", "Pyrimidine salvage"], "P04196": ["Platelet degranulation ", "Dissolution of Fibrin Clot"], "P04211": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P04216": ["Post-translational modification: synthesis of GPI-anchored proteins"], "P04217": ["Platelet degranulation ", "Neutrophil degranulation"], "P04222": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "DAP12 interactions", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P04229": ["Downstream TCR signaling", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "MHC class II antigen presentation", "PD-1 signaling", "Interferon gamma signaling"], "P04233": ["Cell surface interactions at the vascular wall", "MHC class II antigen presentation"], "P04234": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Downstream TCR signaling", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "PD-1 signaling", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "P04259": ["Keratinization", "Formation of the cornified envelope"], "P04264": ["Neutrophil degranulation", "Keratinization", "Formation of the cornified envelope"], "P04271": ["Nuclear signaling by ERBB4", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "Advanced glycosylation endproduct receptor signaling", "Advanced glycosylation endproduct receptor signaling", "TRAF6 mediated NF-kB activation"], "P04275": ["Platelet degranulation ", "Intrinsic Pathway of Fibrin Clot Formation", "Integrin cell surface interactions", "Integrin alphaIIb beta3 signaling", "GRB2:SOS provides linkage to MAPK signaling for Integrins ", "p130Cas linkage to MAPK signaling for integrins", "GP1b-IX-V activation signalling", "MAP2K and MAPK activation", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF", "Platelet Adhesion to exposed collagen", "Platelet Aggregation (Plug Formation)"], "P04279": ["Antimicrobial peptides", "Amyloid fiber formation"], "P04350": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "Gap junction assembly", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Regulation of PLK1 Activity at G2/M Transition", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Prefoldin mediated transfer of substrate to CCT/TriC", "Formation of tubulin folding intermediates by CCT/TriC", "Post-chaperonin tubulin folding pathway", "Recycling pathway of L1", "Recycling pathway of L1", "Hedgehog 'off' state", "Cilium Assembly", "Anchoring of the basal body to the plasma membrane", "Intraflagellar transport", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "AURKA Activation by TPX2", "Carboxyterminal post-translational modifications of tubulin", "Carboxyterminal post-translational modifications of tubulin", "Activation of AMPK downstream of NMDARs", "Kinesins"], "P04406": ["Glycolysis", "Gluconeogenesis"], "P04424": ["Urea cycle"], "P04430": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P04432": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P04433": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P04435": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Downstream TCR signaling", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "PD-1 signaling"], "P04437": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Downstream TCR signaling", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "PD-1 signaling"], "P04439": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "E3 ubiquitin ligases ubiquitinate target proteins", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P04440": ["Downstream TCR signaling", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "MHC class II antigen presentation", "PD-1 signaling", "Interferon gamma signaling"], "P04578": ["Alpha-defensins", "Budding and maturation of HIV virion", "Synthesis and processing of ENV and VPU", "Binding and entry of HIV virion", "Assembly Of The HIV Virion", "Dectin-2 family"], "P04579": ["Dectin-2 family"], "P04580": ["Dectin-2 family"], "P04581": ["Dectin-2 family"], "P04582": ["Dectin-2 family"], "P04583": ["Dectin-2 family"], "P04585": ["Uncoating of the HIV Virion", "Budding and maturation of HIV virion", "Integration of provirus", "Early Phase of HIV Life Cycle", "Minus-strand DNA synthesis", "Plus-strand DNA synthesis", "2-LTR circle formation", "Binding and entry of HIV virion", "Assembly Of The HIV Virion", "Integration of viral DNA into host genomic DNA", "Autointegration results in viral DNA circles", "APOBEC3G mediated resistance to HIV-1 infection", "Vpr-mediated nuclear import of PICs"], "P04591": ["Uncoating of the HIV Virion", "Budding and maturation of HIV virion", "Integration of provirus", "Early Phase of HIV Life Cycle", "Minus-strand DNA synthesis", "Plus-strand DNA synthesis", "2-LTR circle formation", "Binding and entry of HIV virion", "Membrane binding and targetting of GAG proteins", "Synthesis And Processing Of GAG, GAGPOL Polyproteins", "Assembly Of The HIV Virion", "Integration of viral DNA into host genomic DNA", "Autointegration results in viral DNA circles", "APOBEC3G mediated resistance to HIV-1 infection", "Vpr-mediated nuclear import of PICs"], "P04601": ["Uncoating of the HIV Virion", "Budding and maturation of HIV virion", "Late Phase of HIV Life Cycle", "Nef mediated downregulation of CD28 cell surface expression", "Nef mediated downregulation of MHC class I complex cell surface expression", "Nef and signal transduction", "Nef Mediated CD4 Down-regulation", "Binding and entry of HIV virion", "Assembly Of The HIV Virion", "Nef Mediated CD8 Down-regulation"], "P04608": ["Formation of HIV-1 elongation complex containing HIV-1 Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "Interactions of Tat with host cellular proteins"], "P04618": ["Uncoating of the HIV Virion", "Budding and maturation of HIV virion", "Integration of provirus", "Early Phase of HIV Life Cycle", "Minus-strand DNA synthesis", "Plus-strand DNA synthesis", "2-LTR circle formation", "Rev-mediated nuclear export of HIV RNA", "Binding and entry of HIV virion", "Assembly Of The HIV Virion", "Integration of viral DNA into host genomic DNA", "Autointegration results in viral DNA circles", "APOBEC3G mediated resistance to HIV-1 infection", "Nuclear import of Rev protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs"], "P04624": ["Dectin-2 family"], "P04626": ["Signaling by ERBB2", "SHC1 events in ERBB2 signaling", "SHC1 events in ERBB2 signaling", "PLCG1 events in ERBB2 signaling", "PIP3 activates AKT signaling", "GRB7 events in ERBB2 signaling", "Downregulation of ERBB2:ERBB3 signaling", "GRB2 events in ERBB2 signaling", "GRB2 events in ERBB2 signaling", "PI3K events in ERBB2 signaling", "Constitutive Signaling by Aberrant PI3K in Cancer", "Sema4D induced cell migration and growth-cone collapse", "RAF/MAP kinase cascade", "ERBB2 Regulates Cell Motility", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "ERBB2 Activates PTK6 Signaling", "Downregulation of ERBB2 signaling", "TFAP2 (AP-2) family regulates transcription of growth factors and their receptors"], "P04628": ["TCF dependent signaling in response to WNT", "TCF dependent signaling in response to WNT", "WNT ligand biogenesis and trafficking", "WNT ligand biogenesis and trafficking", "Class B/2 (Secretin family receptors)", "Transcriptional regulation of white adipocyte differentiation", "PCP/CE pathway", "PCP/CE pathway", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Disassembly of the destruction complex and recruitment of AXIN to the membrane"], "P04629": ["PLC-gamma1 signalling", "Signalling to RAS", "ARMS-mediated activation", "ARMS-mediated activation", "Retrograde neurotrophin signalling", "Retrograde neurotrophin signalling", "NGF-independant TRKA activation", "TRKA activation by NGF", "TRKA activation by NGF", "Signalling to p38 via RIT and RIN", "PI3K/AKT activation", "PI3K/AKT activation", "Signalling to STAT3"], "P04629-1": ["Frs2-mediated activation", "Frs2-mediated activation", "TRKA activation by NGF"], "P04632": ["Degradation of the extracellular matrix", "Degradation of the extracellular matrix", "Formation of the cornified envelope", "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models"], "P04637": ["Activation of NOXA and translocation to mitochondria", "Activation of PUMA and translocation to mitochondria", "Pre-NOTCH Transcription and Translation", "Oxidative Stress Induced Senescence", "Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "Oncogene Induced Senescence", "DNA Damage/Telomere Stress Induced Senescence", "SUMOylation of transcription factors", "Autodegradation of the E3 ubiquitin ligase COP1", "Association of TriC/CCT with target proteins during biosynthesis", "TP53 Regulates Metabolic Genes", "Ub-specific processing proteases", "Ovarian tumor domain proteases", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Interleukin-4 and Interleukin-13 signaling", "TP53 Regulates Transcription of DNA Repair Genes", "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "TP53 Regulates Transcription of Caspase Activators and Caspases", "TP53 Regulates Transcription of Death Receptors and Ligands", "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "Regulation of TP53 Expression", "Regulation of TP53 Activity through Phosphorylation", "Regulation of TP53 Degradation", "Regulation of TP53 Activity through Acetylation", "Regulation of TP53 Activity through Association with Co-factors", "Regulation of TP53 Activity through Methylation", "PI5P Regulates TP53 Acetylation", "G2/M DNA damage checkpoint", "G2/M Checkpoints", "Stabilization of p53", "Transcriptional activation of cell cycle inhibitor p21 ", "The role of GTSE1 in G2/M progression after G2 checkpoint", "RUNX3 regulates CDKN1A transcription", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription", "Factors involved in megakaryocyte development and platelet production"], "P04731": ["Metallothioneins bind metals", "Metallothioneins bind metals"], "P04732": ["Metallothioneins bind metals"], "P04733": ["Metallothioneins bind metals"], "P04745": ["Digestion of dietary carbohydrate"], "P04746": ["Digestion of dietary carbohydrate"], "P04792": ["VEGFA-VEGFR2 Pathway", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "MAPK6/MAPK4 signaling"], "P04798": ["PPARA activates gene expression", "Xenobiotics", "Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)", "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)", "Biosynthesis of protectins"], "P04818": ["Interconversion of nucleotide di- and triphosphates", "Activation of E2F1 target genes at G1/S"], "P04839": ["ROS, RNS production in phagocytes", "Cross-presentation of particulate exogenous antigens (phagosomes)", "Detoxification of Reactive Oxygen Species", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate NADPH Oxidases", "Neutrophil degranulation"], "P04843": ["SRP-dependent cotranslational protein targeting to membrane", "Asparagine N-linked glycosylation"], "P04844": ["SRP-dependent cotranslational protein targeting to membrane", "Asparagine N-linked glycosylation"], "P04853": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "P04899": ["PLC beta mediated events", "PLC beta mediated events", "Adenylate cyclase inhibitory pathway", "Adenylate cyclase inhibitory pathway", "G-protein activation", "ADP signalling through P2Y purinoceptor 12", "Adrenaline,noradrenaline inhibits insulin secretion", "Adrenaline,noradrenaline inhibits insulin secretion", "G alpha (s) signalling events", "G alpha (i) signalling events", "G alpha (i) signalling events", "G alpha (z) signalling events", "Regulation of insulin secretion", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "P04908": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "HATs acetylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "UCH proteinases", "Ub-specific processing proteases", "Metalloprotease DUBs", "Deposition of new CENPA-containing nucleosomes at the centromere", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "P04920": ["Bicarbonate transporters"], "P04921": ["Cell surface interactions at the vascular wall"], "P04949": ["Toll Like Receptor 5 (TLR5) Cascade", "MyD88 deficiency (TLR5)", "IRAK4 deficiency (TLR5)", "MyD88 cascade initiated on plasma membrane"], "P04958": ["Toxicity of tetanus toxin (TeNT)"], "P05013": ["Interferon alpha/beta signaling", "Regulation of IFNA signaling", "Regulation of IFNA signaling", "TRAF6 mediated IRF7 activation", "Factors involved in megakaryocyte development and platelet production"], "P05014": ["Interferon alpha/beta signaling", "Regulation of IFNA signaling", "Regulation of IFNA signaling", "TRAF6 mediated IRF7 activation", "Factors involved in megakaryocyte development and platelet production"], "P05015": ["Interferon alpha/beta signaling", "Regulation of IFNA signaling", "Regulation of IFNA signaling", "TRAF6 mediated IRF7 activation", "Factors involved in megakaryocyte development and platelet production"], "P05019": ["Platelet degranulation ", "Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "IRS-related events triggered by IGF1R", "SHC-related events triggered by IGF1R", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Synthesis, secretion, and deacylation of Ghrelin"], "P05023": ["Ion homeostasis", "Ion transport by P-type ATPases"], "P05026": ["Basigin interactions", "Ion homeostasis", "Ion transport by P-type ATPases"], "P05060": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "P05062": ["Hereditary fructose intolerance", "Glycolysis", "Gluconeogenesis", "Fructose catabolism"], "P05067": ["Platelet degranulation ", "ECM proteoglycans", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "G alpha (q) signalling events", "G alpha (i) signalling events", "Lysosome Vesicle Biogenesis", "Formyl peptide receptors bind formyl peptides and many other ligands", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "The NLRP3 inflammasome", "Advanced glycosylation endproduct receptor signaling", "Advanced glycosylation endproduct receptor signaling", "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "Post-translational protein phosphorylation", "TRAF6 mediated NF-kB activation", "Amyloid fiber formation"], "P05089": ["Neutrophil degranulation", "Urea cycle"], "P05090": ["Transport of fatty acids"], "P05091": ["Metabolism of serotonin", "Ethanol oxidation"], "P05093": ["Androgen biosynthesis", "Glucocorticoid biosynthesis", "Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)"], "P05106": ["Platelet degranulation ", "Elastic fibre formation", "PECAM1 interactions", "Molecules associated with elastic fibres", "Integrin cell surface interactions", "Integrin cell surface interactions", "Syndecan interactions", "Syndecan interactions", "ECM proteoglycans", "Integrin alphaIIb beta3 signaling", "GRB2:SOS provides linkage to MAPK signaling for Integrins ", "p130Cas linkage to MAPK signaling for integrins", "VEGFA-VEGFR2 Pathway", "Signal transduction by L1", "MAP2K and MAPK activation", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF"], "P05107": ["Toll Like Receptor 4 (TLR4) Cascade", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "Integrin cell surface interactions", "Interleukin-4 and Interleukin-13 signaling", "Neutrophil degranulation"], "P05108": ["Pregnenolone biosynthesis", "Endogenous sterols", "Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)"], "P05109": ["RHO GTPases Activate NADPH Oxidases", "Regulation of TLR by endogenous ligand", "Neutrophil degranulation", "Metal sequestration by antimicrobial proteins"], "P05111": ["Glycoprotein hormones"], "P05112": ["Interleukin-4 and Interleukin-13 signaling", "Interleukin-18 signaling"], "P05113": ["Interleukin-3, Interleukin-5 and GM-CSF signaling", "RAF/MAP kinase cascade", "Interleukin receptor SHC signaling"], "P05114": ["Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER"], "P05120": ["Dissolution of Fibrin Clot", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "P05121": ["Platelet degranulation ", "BMAL1:CLOCK,NPAS2 activates circadian gene expression", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "ECM proteoglycans", "Dissolution of Fibrin Clot"], "P05129": ["Calmodulin induced events", "Disinhibition of SNARE formation", "Trafficking of GluR2-containing AMPA receptors", "G alpha (z) signalling events", "WNT5A-dependent internalization of FZD4", "Response to elevated platelet cytosolic Ca2+"], "P05141": ["Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization", "Regulation of insulin secretion"], "P05154": ["Intrinsic Pathway of Fibrin Clot Formation", "Common Pathway of Fibrin Clot Formation"], "P05155": ["Platelet degranulation ", "Intrinsic Pathway of Fibrin Clot Formation", "Regulation of Complement cascade"], "P05156": ["Regulation of Complement cascade"], "P05160": ["Common Pathway of Fibrin Clot Formation"], "P05161": ["ISG15 antiviral mechanism", "NS1 Mediated Effects on Host Pathways", "DDX58/IFIH1-mediated induction of interferon-alpha/beta", "Termination of translesion DNA synthesis", "Interferon alpha/beta signaling", "Negative regulators of DDX58/IFIH1 signaling"], "P05164": ["Neutrophil degranulation", "Events associated with phagocytolytic activity of PMN cells"], "P05165": ["Biotin transport and metabolism", "Defective HLCS causes multiple carboxylase deficiency", "Propionyl-CoA catabolism"], "P05166": ["Biotin transport and metabolism", "Defective HLCS causes multiple carboxylase deficiency", "Propionyl-CoA catabolism"], "P05177": ["Methylation", "Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2", "Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)", "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)", "Aflatoxin activation and detoxification", "Biosynthesis of protectins", "Biosynthesis of maresin-like SPMs"], "P05181": ["Xenobiotics", "CYP2E1 reactions", "Biosynthesis of maresin-like SPMs"], "P05186": ["Post-translational modification: synthesis of GPI-anchored proteins"], "P05187": ["Intra-Golgi traffic"], "P05198": ["L13a-mediated translational silencing of Ceruloplasmin expression", "PERK regulates gene expression", "ABC-family proteins mediated transport", "Translation initiation complex formation", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Recycling of eIF2:GDP"], "P05230": ["PI3K Cascade", "PIP3 activates AKT signaling", "Signaling by activated point mutants of FGFR1", "Signaling by activated point mutants of FGFR3", "FGFR4 ligand binding and activation", "FGFR1b ligand binding and activation", "FGFR3b ligand binding and activation", "FGFR3c ligand binding and activation", "FGFR1c ligand binding and activation", "FGFR2c ligand binding and activation", "FGFR2b ligand binding and activation", "FGFR3 mutant receptor activation", "Activated point mutants of FGFR2", "Constitutive Signaling by Aberrant PI3K in Cancer", "Phospholipase C-mediated cascade: FGFR1", "Phospholipase C-mediated cascade; FGFR2", "Phospholipase C-mediated cascade; FGFR3", "Phospholipase C-mediated cascade; FGFR4", "Downstream signaling of activated FGFR1", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "PI-3K cascade:FGFR3", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "PI-3K cascade:FGFR4", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "Signaling by FGFR2 in disease", "Signaling by FGFR1 in disease", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Signaling by FGFR2 IIIa TM", "Signaling by FGFR3 point mutants in cancer"], "P05231": ["Interleukin-6 signaling", "MAPK3 (ERK1) activation", "MAPK1 (ERK2) activation", "Senescence-Associated Secretory Phenotype (SASP)", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Interleukin-10 signaling", "Interleukin-4 and Interleukin-13 signaling", "Post-translational protein phosphorylation"], "P05305": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "P05362": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Integrin cell surface interactions", "Interleukin-10 signaling", "Interleukin-4 and Interleukin-13 signaling", "Interferon gamma signaling"], "P05386": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P05387": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P05388": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P05412": ["Pre-NOTCH Transcription and Translation", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "FCERI mediated MAPK activation", "Activation of the AP-1 family of transcription factors", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "MAPK6/MAPK4 signaling", "TP53 Regulates Transcription of DNA Repair Genes", "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription", "Estrogen-dependent gene expression"], "P05413": ["Triglyceride catabolism"], "P05423": ["Cytosolic sensors of pathogen-associated DNA ", "RNA Polymerase III Chain Elongation", "RNA Polymerase III Transcription Termination", "RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "P05452": ["Platelet degranulation "], "P05455": ["RNA Polymerase III Transcription Termination", "RNA Polymerase III Abortive And Retractive Initiation"], "P05496": ["Mitochondrial protein import", "Mitochondrial protein import", "Formation of ATP by chemiosmotic coupling", "Cristae formation"], "P05534": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P05538": ["Downstream TCR signaling", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "MHC class II antigen presentation", "PD-1 signaling", "Interferon gamma signaling"], "P05546": ["Intrinsic Pathway of Fibrin Clot Formation", "Common Pathway of Fibrin Clot Formation", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "P05549": ["Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors", "Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "TFAP2 (AP-2) family regulates transcription of other transcription factors", "Activation of the TFAP2 (AP-2) family of transcription factors", "TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "TFAP2 (AP-2) family regulates transcription of cell cycle factors", "TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation"], "P05549-1": ["SUMOylation of transcription factors", "Negative regulation of activity of TFAP2 (AP-2) family transcription factors"], "P05556": ["Elastic fibre formation", "Fibronectin matrix formation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "Basigin interactions", "Molecules associated with elastic fibres", "Integrin cell surface interactions", "Integrin cell surface interactions", "Laminin interactions", "Laminin interactions", "Syndecan interactions", "ECM proteoglycans", "Other semaphorin interactions", "Signal transduction by L1", "Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "CHL1 interactions", "RHO GTPases Activate Formins", "Interleukin-4 and Interleukin-13 signaling", "Platelet Adhesion to exposed collagen", "MET activates PTK2 signaling", "MET interacts with TNS proteins"], "P05771": ["Disinhibition of SNARE formation", "Activation of NF-kappaB in B cells", "Trafficking of GluR2-containing AMPA receptors", "G alpha (z) signalling events", "Depolymerisation of the Nuclear Lamina", "WNT5A-dependent internalization of FZD4", "VEGFR2 mediated cell proliferation", "RHO GTPases Activate NADPH Oxidases", "Response to elevated platelet cytosolic Ca2+", "RUNX1 regulates transcription of genes involved in differentiation of myeloid cells"], "P05783": ["Keratinization", "Formation of the cornified envelope"], "P05787": ["Keratinization", "Formation of the cornified envelope"], "P05814": ["Nuclear signaling by ERBB4"], "P05877": ["Dectin-2 family"], "P05878": ["Dectin-2 family"], "P05879": ["Dectin-2 family"], "P05880": ["Dectin-2 family"], "P05881": ["Dectin-2 family"], "P05882": ["Dectin-2 family"], "P05919": ["Uncoating of the HIV Virion", "Budding and maturation of HIV virion", "Integration of provirus", "Early Phase of HIV Life Cycle", "Minus-strand DNA synthesis", "Plus-strand DNA synthesis", "2-LTR circle formation", "Synthesis and processing of ENV and VPU", "Binding and entry of HIV virion", "Assembly Of The HIV Virion", "Integration of viral DNA into host genomic DNA", "Autointegration results in viral DNA circles", "Vpu mediated degradation of CD4", "APOBEC3G mediated resistance to HIV-1 infection", "Vpr-mediated nuclear import of PICs"], "P05937": ["Amyloid fiber formation"], "P05976": ["Striated Muscle Contraction"], "P05981": ["MET Receptor Activation", "Signaling by MST1"], "P05997": ["Collagen degradation", "Extracellular matrix organization", "Collagen biosynthesis and modifying enzymes", "Signaling by PDGF", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "Syndecan interactions", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "NCAM1 interactions", "MET activates PTK2 signaling", "Collagen chain trimerization"], "P06028": ["Cell surface interactions at the vascular wall"], "P06126": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "P06132": ["Heme biosynthesis"], "P06133": ["Glucuronidation"], "P06179": ["The IPAF inflammasome", "The IPAF inflammasome"], "P06213": ["PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "IRS activation", "Signal attenuation", "Insulin receptor signalling cascade", "Signaling by Insulin receptor", "Insulin receptor recycling"], "P06239": ["GPVI-mediated activation cascade", "PIP3 activates AKT signaling", "Signaling by SCF-KIT", "Signaling by SCF-KIT", "Regulation of KIT signaling", "Nef and signal transduction", "Nef Mediated CD4 Down-regulation", "Downstream TCR signaling", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "PECAM1 interactions", "Constitutive Signaling by Aberrant PI3K in Cancer", "DAP12 signaling", "DAP12 signaling", "CD28 co-stimulation", "CD28 dependent PI3K/Akt signaling", "CD28 dependent Vav1 pathway", "CTLA4 inhibitory signaling", "PD-1 signaling", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Interleukin-2 signaling"], "P06241": ["GPVI-mediated activation cascade", "Signaling by ERBB2", "PIP3 activates AKT signaling", "Signaling by SCF-KIT", "Signaling by SCF-KIT", "Regulation of KIT signaling", "Nef and signal transduction", "Cell surface interactions at the vascular wall", "FCGR activation", "PECAM1 interactions", "Constitutive Signaling by Aberrant PI3K in Cancer", "DAP12 signaling", "DAP12 signaling", "EPH-Ephrin signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Nephrin family interactions", "Nephrin family interactions", "NCAM signaling for neurite out-growth", "NCAM signaling for neurite out-growth", "CD28 co-stimulation", "CD28 dependent PI3K/Akt signaling", "CD28 dependent Vav1 pathway", "CTLA4 inhibitory signaling", "EPHB-mediated forward signaling", "EPHB-mediated forward signaling", "EPHA-mediated growth cone collapse", "EPHA-mediated growth cone collapse", "Ephrin signaling", "Ephrin signaling", "EPH-ephrin mediated repulsion of cells", "Sema3A PAK dependent Axon repulsion", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "CRMPs in Sema3A signaling", "CRMPs in Sema3A signaling", "VEGFA-VEGFR2 Pathway", "Dectin-2 family", "CD209 (DC-SIGN) signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Platelet Adhesion to exposed collagen", "Reelin signalling pathway", "Regulation of signaling by CBL", "Regulation of signaling by CBL", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P06241-1": ["DCC mediated attractive signaling", "DCC mediated attractive signaling", "Activated NTRK2 signals through FYN", "NTRK2 activates RAC1", "NTRK2 activates RAC1"], "P06276": ["Neurotransmitter clearance", "Synthesis of PC", "Synthesis, secretion, and deacylation of Ghrelin"], "P06280": ["Glycosphingolipid metabolism", "Neutrophil degranulation"], "P06307": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "P06310": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P06312": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P06315": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P06331": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P06340": ["MHC class II antigen presentation"], "P06396": ["Caspase-mediated cleavage of cytoskeletal proteins", "Neutrophil degranulation", "Amyloid fiber formation"], "P06400": ["Inhibition of replication initiation of damaged DNA by RB1/E2F1", "Inhibition of replication initiation of damaged DNA by RB1/E2F1", "Condensation of Prophase Chromosomes", "Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "Oncogene Induced Senescence", "Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes", "Cyclin E associated events during G1/S transition ", "Cyclin D associated events in G1", "Cyclin A:Cdk2-associated events at S phase entry", "RUNX2 regulates osteoblast differentiation"], "P06401": ["Nuclear signaling by ERBB4", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Nuclear Receptor transcription pathway", "SUMOylation of intracellular receptors", "Estrogen-dependent gene expression"], "P06401-2": ["Nuclear Receptor transcription pathway"], "P06493": ["MAPK3 (ERK1) activation", "E2F-enabled inhibition of pre-replication complex formation", "Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1", "Golgi Cisternae Pericentriolar Stack Reorganization", "Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes", "APC/C:Cdc20 mediated degradation of Cyclin B", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Regulation of APC/C activators between G1/S and early anaphase", "Phosphorylation of the APC/C", "Phosphorylation of Emi1", "Condensation of Prophase Chromosomes", "MASTL Facilitates Mitotic Progression", "Resolution of Sister Chromatid Cohesion", "Condensation of Prometaphase Chromosomes", "Regulation of PLK1 Activity at G2/M Transition", "Activation of NIMA Kinases NEK9, NEK6, NEK7", "Nuclear Pore Complex (NPC) Disassembly", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Depolymerisation of the Nuclear Lamina", "Activation of E2F1 target genes at G1/S", "Anchoring of the basal body to the plasma membrane", "MAPK6/MAPK4 signaling", "Ovarian tumor domain proteases", "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "Regulation of TP53 Degradation", "Mitotic Prophase", "Cyclin A/B1/B2 associated events during G2/M transition", "Cyclin A/B1/B2 associated events during G2/M transition", "G2/M DNA replication checkpoint", "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "The role of GTSE1 in G2/M progression after G2 checkpoint", "AURKA Activation by TPX2", "Transcriptional regulation by RUNX2"], "P06576": ["Mitochondrial protein import", "Mitochondrial protein import", "Formation of ATP by chemiosmotic coupling", "Transcriptional activation of mitochondrial biogenesis", "Cristae formation"], "P06681": ["Initial triggering of complement", "Activation of C3 and C5", "Regulation of Complement cascade"], "P06702": ["RHO GTPases Activate NADPH Oxidases", "Regulation of TLR by endogenous ligand", "Neutrophil degranulation", "Metal sequestration by antimicrobial proteins"], "P06725": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "P06727": ["Chylomicron assembly", "Assembly of active LPL and LIPC lipase complexes", "Chylomicron remodeling", "Retinoid metabolism and transport", "Retinoid metabolism and transport", "Amyloid fiber formation"], "P06729": ["Cell surface interactions at the vascular wall"], "P06730": ["ISG15 antiviral mechanism", "L13a-mediated translational silencing of Ceruloplasmin expression", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "mTORC1-mediated signalling", "Deadenylation of mRNA", "Translation initiation complex formation", "Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "P06731": ["Post-translational modification: synthesis of GPI-anchored proteins", "Cell surface interactions at the vascular wall"], "P06732": ["Creatine metabolism"], "P06733": ["Glycolysis", "Gluconeogenesis"], "P06734": ["NOTCH2 intracellular domain regulates transcription", "Interleukin-10 signaling", "Interleukin-4 and Interleukin-13 signaling"], "P06737": ["Neutrophil degranulation", "Glycogen breakdown (glycogenolysis)"], "P06744": ["TP53 Regulates Metabolic Genes", "Neutrophil degranulation", "Glycolysis", "Gluconeogenesis"], "P06746": ["POLB-Dependent Long Patch Base Excision Repair", "Resolution of AP sites via the multiple-nucleotide patch replacement pathway", "Resolution of AP sites via the single-nucleotide replacement pathway", "APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "PCNA-Dependent Long Patch Base Excision Repair", "Ub-specific processing proteases", "Abasic sugar-phosphate removal via the single-nucleotide replacement pathway"], "P06748": ["Nuclear import of Rev protein", "Nuclear import of Rev protein", "SUMOylation of transcription cofactors", "Deposition of new CENPA-containing nucleosomes at the centromere", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation"], "P06753": ["Striated Muscle Contraction", "Smooth Muscle Contraction"], "P06756": ["Cross-presentation of particulate exogenous antigens (phagosomes)", "Elastic fibre formation", "PECAM1 interactions", "Molecules associated with elastic fibres", "Integrin cell surface interactions", "Integrin cell surface interactions", "Laminin interactions", "Syndecan interactions", "Syndecan interactions", "ECM proteoglycans", "VEGFA-VEGFR2 Pathway", "Signal transduction by L1", "Neutrophil degranulation"], "P06821": ["Influenza Life Cycle", "Entry of Influenza Virion into Host Cell via Endocytosis", "Fusion of the Influenza Virion to the Host Cell Endosome", "Release", "Budding", "Packaging of Eight RNA Segments", "Assembly of Viral Components at the Budding Site", "Uncoating of the Influenza Virion", "Transport of HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum to the Golgi Apparatus", "Viral mRNA Translation"], "P06850": ["Class B/2 (Secretin family receptors)", "G alpha (s) signalling events", "MECP2 regulates transcription of neuronal ligands"], "P06858": ["Transcriptional regulation of white adipocyte differentiation", "Assembly of active LPL and LIPC lipase complexes", "Chylomicron remodeling", "Retinoid metabolism and transport"], "P06865": ["Glycosphingolipid metabolism", "Keratan sulfate degradation", "CS/DS degradation", "Hyaluronan uptake and degradation", "Defective HEXA causes GM2G1"], "P06870": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "P06881": ["G alpha (s) signalling events", "Calcitonin-like ligand receptors"], "P06899": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "HATs acetylate histones", "HATs acetylate histones", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Ub-specific processing proteases", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "E3 ubiquitin ligases ubiquitinate target proteins", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "P07093": ["Intrinsic Pathway of Fibrin Clot Formation", "Common Pathway of Fibrin Clot Formation", "Dissolution of Fibrin Clot"], "P07098": ["Digestion of dietary lipid"], "P07099": ["Phase I - Functionalization of compounds"], "P07101": ["Catecholamine biosynthesis"], "P07108": ["Mitochondrial Fatty Acid Beta-Oxidation"], "P07148": ["Triglyceride catabolism", "PPARA activates gene expression", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)"], "P07195": ["Pyruvate metabolism"], "P07196": ["Unblocking of NMDA receptors, glutamate binding and activation", "Unblocking of NMDA receptors, glutamate binding and activation", "Ras activation upon Ca2+ influx through NMDA receptor", "RAF/MAP kinase cascade", "Negative regulation of NMDA receptor-mediated neuronal transmission", "Long-term potentiation"], "P07202": ["Thyroxine biosynthesis"], "P07203": ["Synthesis of 5-eicosatetraenoic acids", "Synthesis of 12-eicosatetraenoic acid derivatives", "Synthesis of 15-eicosatetraenoic acid derivatives", "Detoxification of Reactive Oxygen Species", "Purine catabolism"], "P07204": ["Common Pathway of Fibrin Clot Formation", "Cell surface interactions at the vascular wall"], "P07205": ["Glycolysis", "Gluconeogenesis"], "P07225": ["Platelet degranulation ", "Common Pathway of Fibrin Clot Formation", "Gamma-carboxylation of protein precursors", "Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "Removal of aminoterminal propeptides from gamma-carboxylated proteins", "Cell surface interactions at the vascular wall", "Regulation of Complement cascade"], "P07237": ["Collagen biosynthesis and modifying enzymes", "Detoxification of Reactive Oxygen Species", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Hedgehog ligand biogenesis", "VLDL assembly", "Post-translational protein phosphorylation", "Chylomicron assembly", "Interleukin-12 signaling", "Interleukin-23 signaling"], "P07288": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3"], "P07305": ["Activation of DNA fragmentation factor", "Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "P07306": ["Asparagine N-linked glycosylation"], "P07307": ["Asparagine N-linked glycosylation"], "P07327": ["Abacavir metabolism", "RA biosynthesis pathway", "Ethanol oxidation"], "P07332": ["Signaling by SCF-KIT", "Sema3A PAK dependent Axon repulsion", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "CRMPs in Sema3A signaling"], "P07333": ["Other interleukin signaling"], "P07339": ["Collagen degradation", "Metabolism of Angiotensinogen to Angiotensins", "MHC class II antigen presentation", "Neutrophil degranulation", "Estrogen-dependent gene expression"], "P07355": ["Smooth Muscle Contraction", "Neutrophil degranulation", "Dissolution of Fibrin Clot", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "P07357": ["Terminal pathway of complement", "Regulation of Complement cascade"], "P07358": ["Terminal pathway of complement", "Regulation of Complement cascade"], "P07359": ["Intrinsic Pathway of Fibrin Clot Formation", "GP1b-IX-V activation signalling", "Platelet Adhesion to exposed collagen", "Platelet Aggregation (Plug Formation)", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"], "P07360": ["Terminal pathway of complement", "Regulation of Complement cascade"], "P07384": ["Degradation of the extracellular matrix", "Degradation of the extracellular matrix", "Neutrophil degranulation", "Formation of the cornified envelope", "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models"], "P07385": ["CASP8 activity is inhibited", "Regulation of TNFR1 signaling"], "P07437": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "Neutrophil degranulation", "AURKA Activation by TPX2"], "P07438": ["Metallothioneins bind metals"], "P07451": ["Reversible hydration of carbon dioxide"], "P07476": ["Formation of the cornified envelope"], "P07477": ["Activation of Matrix Metalloproteinases", "Cobalamin (Cbl, vitamin B12) transport and metabolism"], "P07478": ["Collagen degradation", "Alpha-defensins", "Activation of Matrix Metalloproteinases", "Neutrophil degranulation", "Antimicrobial peptides"], "P07492": ["Peptide ligand-binding receptors", "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "G alpha (q) signalling events"], "P07498": ["Miscellaneous transport and binding events"], "P07510": ["Highly sodium permeable acetylcholine nicotinic receptors"], "P07550": ["Adrenoceptors", "G alpha (s) signalling events", "Ub-specific processing proteases", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "P07585": ["Degradation of the extracellular matrix", "A tetrasaccharide linker sequence is required for GAG synthesis", "Chondroitin sulfate biosynthesis", "Dermatan sulfate biosynthesis", "CS/DS degradation", "ECM proteoglycans", "ECM proteoglycans", "Defective B4GALT7 causes EDS, progeroid type", "Defective B3GAT3 causes JDSSDHD", "Defective CHST3 causes SEDCJD", "Defective CHST14 causes EDS, musculocontractural type", "Defective CHSY1 causes TPBS", "Defective B3GALT6 causes EDSP2 and SEMDJL1"], "P07602": ["Platelet degranulation ", "Glycosphingolipid metabolism", "Peptide ligand-binding receptors", "G alpha (i) signalling events", "Neutrophil degranulation"], "P07686": ["Glycosphingolipid metabolism", "Keratan sulfate degradation", "CS/DS degradation", "Hyaluronan uptake and degradation", "Defective HEXB causes GM2G2", "Neutrophil degranulation"], "P07711": ["Endosomal/Vacuolar pathway", "Collagen degradation", "Degradation of the extracellular matrix", "Trafficking and processing of endosomal TLR", "Assembly of collagen fibrils and other multimeric structures", "MHC class II antigen presentation", "RUNX1 regulates transcription of genes involved in differentiation of keratinocytes"], "P07737": ["Platelet degranulation ", "Signaling by ROBO receptors", "PCP/CE pathway", "RHO GTPases Activate Formins", "RHO GTPases Activate Formins"], "P07738": ["Glycolysis"], "P07741": ["Neutrophil degranulation", "Purine salvage"], "P07766": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Downstream TCR signaling", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "PD-1 signaling"], "P07814": ["SeMet incorporation into proteins", "Cytosolic tRNA aminoacylation", "tRNA modification in the nucleus and cytosol"], "P07858": ["Collagen degradation", "Trafficking and processing of endosomal TLR", "Assembly of collagen fibrils and other multimeric structures", "MHC class II antigen presentation", "Neutrophil degranulation"], "P07864": ["Pyruvate metabolism"], "P07900": ["Signaling by ERBB2", "Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "vRNP Assembly", "Regulation of actin dynamics for phagocytic cup formation", "eNOS activation", "Regulation of PLK1 Activity at G2/M Transition", "Scavenging by Class F Receptors", "Scavenging by Class F Receptors", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "HSF1 activation", "Attenuation phase", "HSF1-dependent transactivation", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Sema3A PAK dependent Axon repulsion", "VEGFA-VEGFR2 Pathway", "VEGFA-VEGFR2 Pathway", "VEGFR2 mediated vascular permeability", "Uptake and function of diphtheria toxin", "PIWI-interacting RNA (piRNA) biogenesis", "Anchoring of the basal body to the plasma membrane", "Constitutive Signaling by EGFRvIII", "Interleukin-4 and Interleukin-13 signaling", "Neutrophil degranulation", "The role of GTSE1 in G2/M progression after G2 checkpoint", "AURKA Activation by TPX2", "Downregulation of ERBB2 signaling", "ESR-mediated signaling", "Estrogen-dependent gene expression"], "P07902": ["Defective GALT can cause Galactosemia", "Galactose catabolism"], "P07910": ["SUMOylation of RNA binding proteins", "mRNA Splicing - Major Pathway", "Processing of Capped Intron-Containing Pre-mRNA"], "P07911": ["Asparagine N-linked glycosylation"], "P07919": ["Respiratory electron transport"], "P07942": ["Degradation of the extracellular matrix", "Laminin interactions", "Laminin interactions", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "L1CAM interactions", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "MET activates PTK2 signaling", "Post-translational protein phosphorylation"], "P07947": ["Signaling by ERBB2", "Signaling by SCF-KIT", "Signaling by SCF-KIT", "Regulation of KIT signaling", "FCGR activation", "PECAM1 interactions", "EPH-Ephrin signaling", "CD28 co-stimulation", "CTLA4 inhibitory signaling", "EPHB-mediated forward signaling", "EPHB-mediated forward signaling", "EPHA-mediated growth cone collapse", "EPHA-mediated growth cone collapse", "EPH-ephrin mediated repulsion of cells", "RUNX2 regulates osteoblast differentiation", "Regulation of signaling by CBL", "Regulation of signaling by CBL"], "P07948": ["GPVI-mediated activation cascade", "Signaling by SCF-KIT", "Signaling by SCF-KIT", "Regulation of KIT signaling", "Cell surface interactions at the vascular wall", "FCGR activation", "PECAM1 interactions", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "EPH-Ephrin signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD28 co-stimulation", "CTLA4 inhibitory signaling", "EPHB-mediated forward signaling", "EPHB-mediated forward signaling", "EPHA-mediated growth cone collapse", "EPHA-mediated growth cone collapse", "EPH-ephrin mediated repulsion of cells", "Dectin-2 family", "CD209 (DC-SIGN) signaling", "CD22 mediated BCR regulation", "Cyclin D associated events in G1", "Platelet Adhesion to exposed collagen", "Signaling by Erythropoietin", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "Erythropoietin activates Phospholipase C gamma (PLCG)", "Erythropoietin activates STAT5", "Erythropoietin activates RAS", "Erythropoietin activates RAS", "Regulation of signaling by CBL", "Regulation of signaling by CBL", "Growth hormone receptor signaling", "Growth hormone receptor signaling", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P07949": ["RAF/MAP kinase cascade", "RET signaling"], "P07951": ["Striated Muscle Contraction", "Smooth Muscle Contraction"], "P07954": ["Citric acid cycle (TCA cycle)"], "P07988": ["Surfactant metabolism", "Defective pro-SFTPB causes pulmonary surfactant metabolism dysfunction 1 (SMDP1) and respiratory distress syndrome (RDS)", "Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5)", "Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)"], "P07992": ["HDR through Single Strand Annealing (SSA)", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Fanconi Anemia Pathway"], "P07996": ["Platelet degranulation ", "Signaling by PDGF", "Integrin cell surface interactions", "Syndecan interactions", "Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"], "P08034": ["Oligomerization of connexins into connexons", "Oligomerization of connexins into connexons", "Transport of connexins along the secretory pathway", "Gap junction assembly"], "P08047": ["PPARA activates gene expression", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Activation of gene expression by SREBF (SREBP)", "Oncogene Induced Senescence", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "Estrogen-dependent gene expression"], "P08069": ["Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "IRS-related events triggered by IGF1R", "SHC-related events triggered by IGF1R"], "P08100": ["The canonical retinoid cycle in rods (twilight vision)", "Activation of the phototransduction cascade", "Activation of the phototransduction cascade", "Inactivation, recovery and regulation of the phototransduction cascade", "Inactivation, recovery and regulation of the phototransduction cascade", "G alpha (i) signalling events", "Opsins", "VxPx cargo-targeting to cilium", "VxPx cargo-targeting to cilium"], "P08123": ["GPVI-mediated activation cascade", "Collagen degradation", "Collagen degradation", "Extracellular matrix organization", "Collagen biosynthesis and modifying enzymes", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Assembly of collagen fibrils and other multimeric structures", "Cell surface interactions at the vascular wall", "Integrin cell surface interactions", "Integrin cell surface interactions", "Anchoring fibril formation", "Crosslinking of collagen fibrils", "Syndecan interactions", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "ECM proteoglycans", "Scavenging by Class A Receptors", "GP1b-IX-V activation signalling", "Interleukin-4 and Interleukin-13 signaling", "Platelet Adhesion to exposed collagen", "Platelet Adhesion to exposed collagen", "Platelet Aggregation (Plug Formation)", "MET activates PTK2 signaling", "Collagen chain trimerization"], "P08133": ["Smooth Muscle Contraction"], "P08134": ["Rho GTPase cycle", "G alpha (12/13) signalling events", "Sema4D induced cell migration and growth-cone collapse", "Sema4D induced cell migration and growth-cone collapse", "RHO GTPases activate PKNs", "RHO GTPases activate CIT", "RHO GTPases activate CIT", "RHO GTPases Activate ROCKs", "RHO GTPases Activate ROCKs", "RHO GTPases Activate Formins", "RHO GTPases Activate Rhotekin and Rhophilins"], "P08138": ["Axonal growth inhibition (RHOA activation)", "NRAGE signals death through JNK", "p75NTR negatively regulates cell cycle via SC1", "Ceramide signalling", "Regulated proteolysis of p75NTR", "NFG and proNGF binds to p75NTR", "NADE modulates death signalling", "NRIF signals cell death from the nucleus", "NRIF signals cell death from the nucleus", "p75NTR recruits signalling complexes", "p75NTR recruits signalling complexes", "NF-kB is activated and signals survival", "Axonal growth stimulation"], "P08151": ["Degradation of GLI1 by the proteasome", "Degradation of GLI1 by the proteasome", "Hedgehog 'off' state", "Hedgehog 'on' state", "GLI proteins bind promoters of Hh responsive genes to promote transcription"], "P08172": ["Muscarinic acetylcholine receptors", "G alpha (i) signalling events", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "P08173": ["Muscarinic acetylcholine receptors", "G alpha (i) signalling events"], "P08174": ["Class B/2 (Secretin family receptors)", "Neutrophil degranulation", "COPI-mediated anterograde transport", "Regulation of Complement cascade"], "P08183": ["Abacavir transmembrane transport", "ABC-family proteins mediated transport"], "P08195": ["Basigin interactions", "Amino acid transport across the plasma membrane", "Tryptophan catabolism"], "P08217": ["Formation of the cornified envelope"], "P08235": ["HSP90 chaperone cycle for steroid hormone receptors (SHR)", "SUMOylation of intracellular receptors"], "P08235-1": ["Nuclear Receptor transcription pathway"], "P08235-2": ["Nuclear Receptor transcription pathway"], "P08235-3": ["Nuclear Receptor transcription pathway"], "P08235-4": ["Nuclear Receptor transcription pathway"], "P08236": ["HS-GAG degradation", "Hyaluronan uptake and degradation", "MPS VII - Sly syndrome", "Neutrophil degranulation"], "P08237": ["Glycolysis"], "P08238": ["Regulation of actin dynamics for phagocytic cup formation", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "HSF1 activation", "Attenuation phase", "HSF1-dependent transactivation", "Sema3A PAK dependent Axon repulsion", "Uptake and function of diphtheria toxin", "Neutrophil degranulation", "The NLRP3 inflammasome", "The role of GTSE1 in G2/M progression after G2 checkpoint", "Aryl hydrocarbon receptor signalling", "ESR-mediated signaling", "Estrogen-dependent gene expression"], "P08240": ["SRP-dependent cotranslational protein targeting to membrane", "XBP1(S) activates chaperone genes"], "P08243": ["ATF4 activates genes", "Amino acid synthesis and interconversion (transamination)"], "P08246": ["Collagen degradation", "Degradation of the extracellular matrix", "Degradation of the extracellular matrix", "Activation of Matrix Metalloproteinases", "Neutrophil degranulation", "Antimicrobial peptides", "Regulation of Complement cascade"], "P08253": ["Collagen degradation", "Collagen degradation", "Degradation of the extracellular matrix", "Degradation of the extracellular matrix", "Activation of Matrix Metalloproteinases", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "EPH-ephrin mediated repulsion of cells", "Interleukin-4 and Interleukin-13 signaling"], "P08254": ["Collagen degradation", "Collagen degradation", "Degradation of the extracellular matrix", "Degradation of the extracellular matrix", "Activation of Matrix Metalloproteinases", "Assembly of collagen fibrils and other multimeric structures", "EGFR Transactivation by Gastrin", "EGFR Transactivation by Gastrin", "Interleukin-4 and Interleukin-13 signaling"], "P08263": ["Glutathione conjugation"], "P08294": ["Detoxification of Reactive Oxygen Species", "Detoxification of Reactive Oxygen Species"], "P08311": ["Degradation of the extracellular matrix", "Activation of Matrix Metalloproteinases", "Metabolism of Angiotensinogen to Angiotensins", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Neutrophil degranulation", "Antimicrobial peptides"], "P08319": ["RA biosynthesis pathway", "Ethanol oxidation"], "P08397": ["Heme biosynthesis"], "P08473": ["Metabolism of Angiotensinogen to Angiotensins", "Neutrophil degranulation"], "P08476": ["Signaling by Activin", "Signaling by Activin", "Glycoprotein hormones", "Antagonism of Activin by Follistatin"], "P08514": ["Platelet degranulation ", "Integrin cell surface interactions", "ECM proteoglycans", "Integrin alphaIIb beta3 signaling", "GRB2:SOS provides linkage to MAPK signaling for Integrins ", "p130Cas linkage to MAPK signaling for integrins", "Signal transduction by L1", "MAP2K and MAPK activation", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"], "P08519": ["LDL remodeling"], "P08559": ["Regulation of pyruvate dehydrogenase (PDH) complex", "Glyoxylate metabolism and glycine degradation", "Signaling by Retinoic Acid", "Pyruvate metabolism"], "P08567": ["Platelet degranulation "], "P08571": ["ER-Phagosome pathway", "Caspase activation via Death Receptors in the presence of ligand", "Toll Like Receptor 4 (TLR4) Cascade", "Transfer of LPS from LBP carrier to CD14", "MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "MyD88-independent TLR4 cascade ", "Toll Like Receptor TLR1:TLR2 Cascade", "Toll Like Receptor TLR6:TLR2 Cascade", "TRIF-mediated programmed cell death", "MyD88 deficiency (TLR2/4)", "IRAK4 deficiency (TLR2/4)", "Regulation of TLR by endogenous ligand", "Neutrophil degranulation", "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon", "IKK complex recruitment mediated by RIP1", "TRAF6-mediated induction of TAK1 complex within TLR4 complex", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"], "P08572": ["Collagen degradation", "Collagen degradation", "Extracellular matrix organization", "Collagen biosynthesis and modifying enzymes", "Signaling by PDGF", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "Integrin cell surface interactions", "Anchoring fibril formation", "Crosslinking of collagen fibrils", "Laminin interactions", "Laminin interactions", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "Scavenging by Class A Receptors", "NCAM1 interactions", "Collagen chain trimerization"], "P08574": ["Mitochondrial protein import", "Respiratory electron transport"], "P08575": ["Phosphorylation of CD3 and TCR zeta chains", "Other semaphorin interactions", "Neutrophil degranulation"], "P08579": ["mRNA Splicing - Major Pathway"], "P08581": ["PIP3 activates AKT signaling", "Constitutive Signaling by Aberrant PI3K in Cancer", "Sema4D mediated inhibition of cell attachment and migration", "RAF/MAP kinase cascade", "MET Receptor Activation", "Negative regulation of MET activity", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "MET activates RAS signaling", "MET activates PI3K/AKT signaling", "MET activates PTPN11", "MET activates PTK2 signaling", "InlB-mediated entry of Listeria monocytogenes into host cell", "InlB-mediated entry of Listeria monocytogenes into host cell", "MET interacts with TNS proteins", "MET activates RAP1 and RAC1", "MET receptor recycling", "MET activates STAT3", "MECP2 regulates neuronal receptors and channels"], "P08582": ["Post-translational modification: synthesis of GPI-anchored proteins", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "P08588": ["Adrenoceptors", "G alpha (s) signalling events"], "P08590": ["Striated Muscle Contraction"], "P08603": ["Regulation of Complement cascade"], "P08620": ["PI3K Cascade", "PIP3 activates AKT signaling", "Signaling by activated point mutants of FGFR1", "Signaling by activated point mutants of FGFR3", "FGFR4 ligand binding and activation", "FGFR3c ligand binding and activation", "FGFR1c ligand binding and activation", "FGFR2c ligand binding and activation", "FGFR3 mutant receptor activation", "Activated point mutants of FGFR2", "Constitutive Signaling by Aberrant PI3K in Cancer", "Phospholipase C-mediated cascade: FGFR1", "Phospholipase C-mediated cascade; FGFR2", "Phospholipase C-mediated cascade; FGFR3", "Phospholipase C-mediated cascade; FGFR4", "Downstream signaling of activated FGFR1", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "PI-3K cascade:FGFR3", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "PI-3K cascade:FGFR4", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "Signaling by FGFR2 in disease", "Signaling by FGFR1 in disease", "FGFRL1 modulation of FGFR1 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Signaling by FGFR3 point mutants in cancer"], "P08621": ["mRNA Splicing - Major Pathway"], "P08631": ["Nef and signal transduction", "FCGR activation", "Regulation of signaling by CBL", "Regulation of signaling by CBL"], "P08637": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis"], "P08648": ["Elastic fibre formation", "Fibronectin matrix formation", "Cell surface interactions at the vascular wall", "Integrin cell surface interactions", "Integrin cell surface interactions", "Signal transduction by L1", "RUNX2 regulates genes involved in cell migration"], "P08651": ["RNA Polymerase III Transcription Termination", "RNA Polymerase III Abortive And Retractive Initiation"], "P08670": ["Caspase-mediated cleavage of cytoskeletal proteins", "Striated Muscle Contraction", "Interleukin-4 and Interleukin-13 signaling"], "P08684": ["Xenobiotics", "Aflatoxin activation and detoxification", "Biosynthesis of maresin-like SPMs"], "P08686": ["Mineralocorticoid biosynthesis", "Glucocorticoid biosynthesis", "Endogenous sterols", "Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)"], "P08697": ["Platelet degranulation ", "Dissolution of Fibrin Clot"], "P08700": ["Interleukin-3, Interleukin-5 and GM-CSF signaling", "RAF/MAP kinase cascade", "RUNX1 regulates transcription of genes involved in interleukin signaling", "Interleukin receptor SHC signaling"], "P08708": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P08709": ["BMAL1:CLOCK,NPAS2 activates circadian gene expression", "Extrinsic Pathway of Fibrin Clot Formation", "Gamma-carboxylation of protein precursors", "Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "Removal of aminoterminal propeptides from gamma-carboxylated proteins"], "P08727": ["Keratinization", "Formation of the cornified envelope"], "P08729": ["Keratinization", "Formation of the cornified envelope"], "P08754": ["PLC beta mediated events", "PLC beta mediated events", "Adenylate cyclase inhibitory pathway", "Adenylate cyclase inhibitory pathway", "G-protein activation", "ADP signalling through P2Y purinoceptor 12", "G alpha (s) signalling events", "G alpha (i) signalling events", "G alpha (i) signalling events", "G alpha (z) signalling events", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "P08758": ["Platelet degranulation "], "P08779": ["Keratinization", "Formation of the cornified envelope"], "P08833": ["ATF4 activates genes", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes"], "P08842": ["Glycosphingolipid metabolism", "The activation of arylsulfatases"], "P08865": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P08887": ["Interleukin-6 signaling", "MAPK3 (ERK1) activation", "MAPK1 (ERK2) activation", "Interleukin-4 and Interleukin-13 signaling"], "P08887-2": ["Interleukin-6 signaling", "MAPK3 (ERK1) activation", "MAPK1 (ERK2) activation"], "P08908": ["Serotonin receptors", "G alpha (i) signalling events"], "P08912": ["Muscarinic acetylcholine receptors", "G alpha (q) signalling events"], "P08913": ["Adrenoceptors", "Adrenaline signalling through Alpha-2 adrenergic receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "G alpha (i) signalling events", "G alpha (z) signalling events", "Surfactant metabolism"], "P08949": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "P08962": ["Platelet degranulation ", "Neutrophil degranulation"], "P09001": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "P09012": ["mRNA Splicing - Major Pathway"], "P09016": ["Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "P09017": ["Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "P09038": ["PI3K Cascade", "PIP3 activates AKT signaling", "Signaling by activated point mutants of FGFR1", "Signaling by activated point mutants of FGFR3", "FGFR4 ligand binding and activation", "FGFR1b ligand binding and activation", "FGFR3c ligand binding and activation", "FGFR1c ligand binding and activation", "FGFR2c ligand binding and activation", "FGFR2b ligand binding and activation", "FGFR3 mutant receptor activation", "Activated point mutants of FGFR2", "Constitutive Signaling by Aberrant PI3K in Cancer", "POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation", "Syndecan interactions", "Non-integrin membrane-ECM interactions", "Phospholipase C-mediated cascade: FGFR1", "Phospholipase C-mediated cascade; FGFR2", "Phospholipase C-mediated cascade; FGFR3", "Phospholipase C-mediated cascade; FGFR4", "Downstream signaling of activated FGFR1", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "PI-3K cascade:FGFR3", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "PI-3K cascade:FGFR4", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "Signaling by FGFR2 in disease", "Signaling by FGFR1 in disease", "FGFRL1 modulation of FGFR1 signaling", "RAF/MAP kinase cascade", "Interleukin-4 and Interleukin-13 signaling", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Signaling by FGFR2 IIIa TM", "Signaling by FGFR3 point mutants in cancer"], "P09086": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes"], "P09104": ["Glycolysis", "Gluconeogenesis"], "P09110": ["alpha-linolenic acid (ALA) metabolism", "Beta-oxidation of very long chain fatty acids", "Neutrophil degranulation", "Peroxisomal protein import", "Peroxisomal protein import", "TYSND1 cleaves peroxisomal proteins"], "P09132": ["SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane"], "P09172": ["Catecholamine biosynthesis"], "P09210": ["Glutathione conjugation", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "P09211": ["Glutathione conjugation", "Detoxification of Reactive Oxygen Species", "Neutrophil degranulation"], "P09234": ["mRNA Splicing - Major Pathway"], "P09237": ["Collagen degradation", "Degradation of the extracellular matrix", "Degradation of the extracellular matrix", "Activation of Matrix Metalloproteinases", "Assembly of collagen fibrils and other multimeric structures"], "P09238": ["Collagen degradation", "Collagen degradation", "Degradation of the extracellular matrix", "Degradation of the extracellular matrix", "Activation of Matrix Metalloproteinases"], "P09326": ["Cell surface interactions at the vascular wall"], "P09341": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events", "Interleukin-10 signaling", "Neutrophil degranulation"], "P09382": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "P09417": ["Phenylalanine and tyrosine catabolism"], "P09429": ["Activation of DNA fragmentation factor", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "Regulation of TLR by endogenous ligand", "Neutrophil degranulation", "Advanced glycosylation endproduct receptor signaling", "Advanced glycosylation endproduct receptor signaling", "TRAF6 mediated NF-kB activation"], "P09455": ["Retinoid cycle disease events", "The canonical retinoid cycle in rods (twilight vision)", "Retinoid metabolism and transport"], "P09467": ["Gluconeogenesis"], "P09471": ["PLC beta mediated events", "PLC beta mediated events", "G-protein activation", "Ca2+ pathway", "Ca2+ pathway", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "P09486": ["Platelet degranulation ", "ECM proteoglycans", "Scavenging by Class H Receptors"], "P09488": ["Glutathione conjugation"], "P09493": ["Striated Muscle Contraction", "Smooth Muscle Contraction"], "P09496": ["Entry of Influenza Virion into Host Cell via Endocytosis", "Retrograde neurotrophin signalling", "Retrograde neurotrophin signalling", "Gap junction degradation", "Formation of annular gap junctions", "MHC class II antigen presentation", "EPH-ephrin mediated repulsion of cells", "Lysosome Vesicle Biogenesis", "Recycling pathway of L1", "Recycling pathway of L1", "WNT5A-dependent internalization of FZD4", "WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "VLDLR internalisation and degradation", "LDL clearance"], "P09496-1": ["MHC class II antigen presentation", "Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis"], "P09497": ["Gap junction degradation", "Formation of annular gap junctions", "EPH-ephrin mediated repulsion of cells", "Lysosome Vesicle Biogenesis", "WNT5A-dependent internalization of FZD4", "WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "P09529": ["Signaling by Activin", "Signaling by Activin", "Glycoprotein hormones", "Antagonism of Activin by Follistatin"], "P09544": ["WNT ligand biogenesis and trafficking", "WNT ligand biogenesis and trafficking", "Class B/2 (Secretin family receptors)"], "P09601": ["Heme degradation", "Interleukin-4 and Interleukin-13 signaling", "Iron uptake and transport"], "P09603": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Other interleukin signaling", "Interleukin-10 signaling", "Post-translational protein phosphorylation"], "P09616": ["The NLRP3 inflammasome"], "P09619": ["PIP3 activates AKT signaling", "Downstream signal transduction", "Signaling by PDGF", "Constitutive Signaling by Aberrant PI3K in Cancer", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "P09622": ["Regulation of pyruvate dehydrogenase (PDH) complex", "Glyoxylate metabolism and glycine degradation", "Signaling by Retinoic Acid", "Glycine degradation", "Pyruvate metabolism", "Branched-chain amino acid catabolism", "Lysine catabolism", "Citric acid cycle (TCA cycle)"], "P09651": ["FGFR2 alternative splicing", "mRNA Splicing - Major Pathway", "Processing of Capped Intron-Containing Pre-mRNA"], "P09661": ["mRNA Splicing - Major Pathway", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "P09668": ["MHC class II antigen presentation", "Surfactant metabolism", "Neutrophil degranulation"], "P09669": ["TP53 Regulates Metabolic Genes", "Respiratory electron transport"], "P09681": ["Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)", "Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)", "G alpha (s) signalling events", "Glucagon-type ligand receptors"], "P09683": ["G alpha (s) signalling events", "Glucagon-type ligand receptors"], "P09693": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Downstream TCR signaling", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "PD-1 signaling", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "P09727": ["E3 ubiquitin ligases ubiquitinate target proteins"], "P09769": ["FCGR activation", "Platelet sensitization by LDL", "Neutrophil degranulation"], "P09848": ["Digestion of dietary carbohydrate", "Intestinal saccharidase deficiencies"], "P09871": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Regulation of Complement cascade"], "P09874": ["POLB-Dependent Long Patch Base Excision Repair", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "SUMOylation of DNA damage response and repair proteins", "HDR through MMEJ (alt-NHEJ)", "DNA Damage Recognition in GG-NER", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER"], "P09884": ["Inhibition of replication initiation of damaged DNA by RB1/E2F1", "Polymerase switching on the C-strand of the telomere", "Telomere C-strand synthesis initiation", "Activation of E2F1 target genes at G1/S", "DNA replication initiation", "Activation of the pre-replicative complex", "Polymerase switching", "Removal of the Flap Intermediate", "Processive synthesis on the lagging strand"], "P09888": ["Cell surface interactions at the vascular wall"], "P09912": ["Interferon alpha/beta signaling"], "P09913": ["Interferon alpha/beta signaling"], "P09914": ["ISG15 antiviral mechanism", "Interferon alpha/beta signaling"], "P09917": ["Synthesis of 5-eicosatetraenoic acids", "Synthesis of Leukotrienes (LT) and Eoxins (EX)", "Synthesis of Lipoxins (LX)", "Interleukin-4 and Interleukin-13 signaling", "Neutrophil degranulation", "Interleukin-18 signaling", "Biosynthesis of D-series resolvins", "Biosynthesis of maresins", "Biosynthesis of E-series 18(S)-resolvins", "Biosynthesis of aspirin-triggered D-series resolvins", "Biosynthesis of E-series 18(R)-resolvins", "Biosynthesis of DPAn-3-derived protectins and resolvins", "Biosynthesis of DPAn-3-derived maresins", "Biosynthesis of DPAn-3-derived 13-series resolvins", "Biosynthesis of electrophilic \u03c9-3 PUFA oxo-derivatives"], "P09919": ["Other interleukin signaling", "Interleukin-10 signaling"], "P09923": ["Synthesis of PA", "Post-translational modification: synthesis of GPI-anchored proteins", "Digestion"], "P09936": ["UCH proteinases"], "P09958": ["Signaling by NODAL", "Collagen degradation", "Collagen degradation", "Elastic fibre formation", "Activation of Matrix Metalloproteinases", "Removal of aminoterminal propeptides from gamma-carboxylated proteins", "NGF processing", "Synthesis and processing of ENV and VPU", "Signaling by PDGF", "Pre-NOTCH Processing in Golgi", "TGF-beta receptor signaling activates SMADs", "Uptake and function of anthrax toxins", "Formation of the cornified envelope", "Assembly of active LPL and LIPC lipase complexes", "Amyloid fiber formation"], "P09960": ["Synthesis of Leukotrienes (LT) and Eoxins (EX)", "Neutrophil degranulation", "Biosynthesis of D-series resolvins", "Biosynthesis of protectins", "Biosynthesis of E-series 18(S)-resolvins", "Biosynthesis of aspirin-triggered D-series resolvins", "Biosynthesis of E-series 18(R)-resolvins"], "P09972": ["Neutrophil degranulation", "Glycolysis", "Gluconeogenesis"], "P0C024": ["Peroxisomal lipid metabolism", "Peroxisomal protein import", "Peroxisomal protein import"], "P0C0L4": ["Initial triggering of complement", "Activation of C3 and C5", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation", "Regulation of Complement cascade"], "P0C0L5": ["Initial triggering of complement", "Activation of C3 and C5", "Regulation of Complement cascade"], "P0C0P6": ["Peptide ligand-binding receptors", "G alpha (q) signalling events", "G alpha (s) signalling events"], "P0C0S5": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Deposition of new CENPA-containing nucleosomes at the centromere", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "P0C0S8": ["HDACs deacetylate histones", "HATs acetylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "UCH proteinases", "Ub-specific processing proteases", "Metalloprotease DUBs"], "P0C0U1": ["Influenza Virus Induced Apoptosis", "Viral mRNA Translation"], "P0C1Z6": ["UCH proteinases", "DNA Damage Recognition in GG-NER"], "P0C5Y4": ["Keratinization"], "P0C5Y9": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Deposition of new CENPA-containing nucleosomes at the centromere", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "P0C604": ["Olfactory Signaling Pathway"], "P0C617": ["Olfactory Signaling Pathway"], "P0C623": ["Olfactory Signaling Pathway"], "P0C626": ["Olfactory Signaling Pathway"], "P0C628": ["Olfactory Signaling Pathway"], "P0C629": ["Olfactory Signaling Pathway"], "P0C645": ["Olfactory Signaling Pathway"], "P0C646": ["Olfactory Signaling Pathway"], "P0C7H8": ["Keratinization"], "P0C7I0": ["Ub-specific processing proteases"], "P0C7M3": ["Surfactant metabolism", "Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5)", "Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)"], "P0C7M7": ["Conjugation of salicylate with glycine"], "P0C7N1": ["Olfactory Signaling Pathway"], "P0C7N5": ["Olfactory Signaling Pathway"], "P0C7N8": ["Olfactory Signaling Pathway"], "P0C7T2": ["Olfactory Signaling Pathway"], "P0C7T3": ["Olfactory Signaling Pathway"], "P0C7X2": ["Generic Transcription Pathway"], "P0C869": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PS", "Acyl chain remodelling of PE", "Acyl chain remodelling of PG", "Hydrolysis of LPC", "Synthesis of PA", "XBP1(S) activates chaperone genes"], "P0CB33": ["Generic Transcription Pathway"], "P0CF74": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P0CG04": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P0CG29": ["Glutathione conjugation"], "P0CG30": ["Glutathione conjugation"], "P0CG37": ["Signaling by NODAL", "Regulation of signaling by NODAL"], "P0CG47": ["Translesion synthesis by REV1", "Recognition of DNA damage by PCNA-containing replication complex", "Translesion Synthesis by POLH", "Activation of NF-kappaB in B cells", "ISG15 antiviral mechanism", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "ER-Phagosome pathway", "Downregulation of ERBB4 signaling", "Spry regulation of FGF signaling", "Downregulation of ERBB2:ERBB3 signaling", "Budding and maturation of HIV virion", "NOD1/2 Signaling Pathway", "TICAM1, RIP1-mediated IKK complex recruitment ", "DDX58/IFIH1-mediated induction of interferon-alpha/beta", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Membrane binding and targetting of GAG proteins", "Assembly Of The HIV Virion", "APC-Cdc20 mediated degradation of Nek2A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "EGFR downregulation", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "TCF dependent signaling in response to WNT", "Downstream TCR signaling", "NRIF signals cell death from the nucleus", "p75NTR recruits signalling complexes", "NF-kB is activated and signals survival", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "NOTCH1 Intracellular Domain Regulates Transcription", "Activated NOTCH1 Transmits Signal to the Nucleus", "Activated NOTCH1 Transmits Signal to the Nucleus", "Downregulation of TGF-beta receptor signaling", "Downregulation of TGF-beta receptor signaling", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Separation of Sister Chromatids", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "Oncogene Induced Senescence", "Regulation of PLK1 Activity at G2/M Transition", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Stimuli-sensing channels", "Constitutive Signaling by NOTCH1 HD Domain Mutants", "FCERI mediated NF-kB activation", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "NOTCH2 Activation and Transmission of Signal to the Nucleus", "Regulation of innate immune responses to cytosolic DNA", "Glycogen synthesis", "Autodegradation of the E3 ubiquitin ligase COP1", "Deactivation of the beta-catenin transactivating complex", "Myoclonic epilepsy of Lafora", "ABC-family proteins mediated transport", "Circadian Clock", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "activated TAK1 mediates p38 MAPK activation", "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Regulation of FZD by ubiquitination", "Pink/Parkin Mediated Mitophagy", "N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Hedgehog 'on' state", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "Translesion synthesis by POLK", "Translesion synthesis by POLI", "Termination of translesion DNA synthesis", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "Negative regulation of MAPK pathway", "Regulation of necroptotic cell death", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAP3K8 (TPL2)-dependent MAPK1/3 activation", "HDR through Homologous Recombination (HRR)", "MAPK6/MAPK4 signaling", "UCH proteinases", "UCH proteinases", "Josephin domain DUBs", "Ub-specific processing proteases", "Ovarian tumor domain proteases", "Metalloprotease DUBs", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Processing of DNA double-strand break ends", "DNA Damage Recognition in GG-NER", "Formation of Incision Complex in GG-NER", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Fanconi Anemia Pathway", "Regulation of TP53 Activity through Phosphorylation", "Regulation of TP53 Degradation", "Regulation of TP53 Activity through Methylation", "Negative regulation of MET activity", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "Cyclin D associated events in G1", "G2/M Checkpoints", "Stabilization of p53", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "Downregulation of ERBB2 signaling", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "E3 ubiquitin ligases ubiquitinate target proteins", "InlB-mediated entry of Listeria monocytogenes into host cell", "InlA-mediated entry of Listeria monocytogenes into host cells", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN localization", "Regulation of PTEN stability and activity", "Neddylation", "ER Quality Control Compartment (ERQC)", "Regulation of expression of SLITs and ROBOs", "Regulation of expression of SLITs and ROBOs", "NOTCH3 Activation and Transmission of Signal to the Nucleus", "NOTCH3 Activation and Transmission of Signal to the Nucleus", "TICAM1-dependent activation of IRF3/IRF7", "TICAM1,TRAF6-dependent induction of TAK1 complex", "Interleukin-1 signaling", "Peroxisomal protein import", "Peroxisomal protein import", "Regulation of signaling by CBL", "Endosomal Sorting Complex Required For Transport (ESCRT)", "Iron uptake and transport", "Negative regulators of DDX58/IFIH1 signaling", "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon", "IRAK1 recruits IKK complex", "IKK complex recruitment mediated by RIP1", "IRAK2 mediated activation of TAK1 complex", "TRAF6-mediated induction of TAK1 complex within TLR4 complex", "Negative regulation of NOTCH4 signaling", "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "Amyloid fiber formation", "Antigen processing: Ubiquitination & Proteasome degradation"], "P0CG48": ["Translesion synthesis by REV1", "Recognition of DNA damage by PCNA-containing replication complex", "Translesion Synthesis by POLH", "Activation of NF-kappaB in B cells", "ISG15 antiviral mechanism", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "ER-Phagosome pathway", "Downregulation of ERBB4 signaling", "Spry regulation of FGF signaling", "Downregulation of ERBB2:ERBB3 signaling", "Budding and maturation of HIV virion", "NOD1/2 Signaling Pathway", "TICAM1, RIP1-mediated IKK complex recruitment ", "DDX58/IFIH1-mediated induction of interferon-alpha/beta", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Membrane binding and targetting of GAG proteins", "Assembly Of The HIV Virion", "APC-Cdc20 mediated degradation of Nek2A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "EGFR downregulation", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "TCF dependent signaling in response to WNT", "Downstream TCR signaling", "NRIF signals cell death from the nucleus", "p75NTR recruits signalling complexes", "NF-kB is activated and signals survival", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "NOTCH1 Intracellular Domain Regulates Transcription", "Activated NOTCH1 Transmits Signal to the Nucleus", "Activated NOTCH1 Transmits Signal to the Nucleus", "Downregulation of TGF-beta receptor signaling", "Downregulation of TGF-beta receptor signaling", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Separation of Sister Chromatids", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "Oncogene Induced Senescence", "Regulation of PLK1 Activity at G2/M Transition", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Stimuli-sensing channels", "Constitutive Signaling by NOTCH1 HD Domain Mutants", "FCERI mediated NF-kB activation", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "NOTCH2 Activation and Transmission of Signal to the Nucleus", "Regulation of innate immune responses to cytosolic DNA", "Glycogen synthesis", "Autodegradation of the E3 ubiquitin ligase COP1", "Deactivation of the beta-catenin transactivating complex", "Myoclonic epilepsy of Lafora", "ABC-family proteins mediated transport", "Circadian Clock", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "activated TAK1 mediates p38 MAPK activation", "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Regulation of FZD by ubiquitination", "Pink/Parkin Mediated Mitophagy", "N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Hedgehog 'on' state", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "Translesion synthesis by POLK", "Translesion synthesis by POLI", "Termination of translesion DNA synthesis", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "Negative regulation of MAPK pathway", "Regulation of necroptotic cell death", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAP3K8 (TPL2)-dependent MAPK1/3 activation", "HDR through Homologous Recombination (HRR)", "MAPK6/MAPK4 signaling", "UCH proteinases", "UCH proteinases", "Josephin domain DUBs", "Ub-specific processing proteases", "Ovarian tumor domain proteases", "Metalloprotease DUBs", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Processing of DNA double-strand break ends", "DNA Damage Recognition in GG-NER", "Formation of Incision Complex in GG-NER", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Fanconi Anemia Pathway", "Regulation of TP53 Activity through Phosphorylation", "Regulation of TP53 Degradation", "Regulation of TP53 Activity through Methylation", "Negative regulation of MET activity", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "Cyclin D associated events in G1", "G2/M Checkpoints", "Stabilization of p53", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "Downregulation of ERBB2 signaling", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "E3 ubiquitin ligases ubiquitinate target proteins", "InlB-mediated entry of Listeria monocytogenes into host cell", "InlA-mediated entry of Listeria monocytogenes into host cells", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN localization", "Regulation of PTEN stability and activity", "Neddylation", "ER Quality Control Compartment (ERQC)", "Regulation of expression of SLITs and ROBOs", "Regulation of expression of SLITs and ROBOs", "NOTCH3 Activation and Transmission of Signal to the Nucleus", "NOTCH3 Activation and Transmission of Signal to the Nucleus", "TICAM1-dependent activation of IRF3/IRF7", "TICAM1,TRAF6-dependent induction of TAK1 complex", "Interleukin-1 signaling", "Peroxisomal protein import", "Peroxisomal protein import", "Regulation of signaling by CBL", "Endosomal Sorting Complex Required For Transport (ESCRT)", "Iron uptake and transport", "Negative regulators of DDX58/IFIH1 signaling", "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon", "IRAK1 recruits IKK complex", "IKK complex recruitment mediated by RIP1", "IRAK2 mediated activation of TAK1 complex", "TRAF6-mediated induction of TAK1 complex within TLR4 complex", "Negative regulation of NOTCH4 signaling", "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "Amyloid fiber formation", "Antigen processing: Ubiquitination & Proteasome degradation"], "P0CH99": ["Generic Transcription Pathway"], "P0DI81": ["COPII-mediated vesicle transport", "RAB GEFs exchange GTP for GDP on RABs"], "P0DJD7": ["Surfactant metabolism"], "P0DJD8": ["Surfactant metabolism"], "P0DJD9": ["Surfactant metabolism"], "P0DJI8": ["Scavenging by Class B Receptors", "G alpha (q) signalling events", "G alpha (i) signalling events", "Formyl peptide receptors bind formyl peptides and many other ligands", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "Interleukin-4 and Interleukin-13 signaling", "Advanced glycosylation endproduct receptor signaling", "Advanced glycosylation endproduct receptor signaling", "TRAF6 mediated NF-kB activation", "Amyloid fiber formation"], "P0DJM0": ["InlA-mediated entry of Listeria monocytogenes into host cells"], "P0DML2": ["Prolactin receptor signaling", "Prolactin receptor signaling", "Growth hormone receptor signaling"], "P0DMM9": ["Cytosolic sulfonation of small molecules", "XBP1(S) activates chaperone genes"], "P0DMN0": ["Cytosolic sulfonation of small molecules"], "P0DMS8": ["Adenosine P1 receptors", "G alpha (i) signalling events"], "P0DMV8": ["Viral RNP Complexes in the Host Cell Nucleus", "Regulation of HSF1-mediated heat shock response", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Attenuation phase", "HSF1-dependent transactivation", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Neutrophil degranulation"], "P0DMV9": ["Regulation of HSF1-mediated heat shock response", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Attenuation phase", "HSF1-dependent transactivation", "Neutrophil degranulation"], "P0DN86": ["Glycoprotein hormones", "TFAP2 (AP-2) family regulates transcription of growth factors and their receptors"], "P0DOY2": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P0DOY3": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P0DP23": ["CaMK IV-mediated phosphorylation of CREB", "CaMK IV-mediated phosphorylation of CREB", "Calmodulin induced events", "Cam-PDE 1 activation", "CaM pathway", "Platelet degranulation ", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "PKA activation", "DARPP-32 events", "Synthesis of IP3 and IP4 in the cytosol", "Calcineurin activates NFAT", "Calcineurin activates NFAT", "eNOS activation", "Transcriptional activation of mitochondrial biogenesis", "Inactivation, recovery and regulation of the phototransduction cascade", "Inactivation, recovery and regulation of the phototransduction cascade", "Stimuli-sensing channels", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "Ca2+ pathway", "Reduction of cytosolic Ca++ levels", "Sodium/Calcium exchangers", "Unblocking of NMDA receptors, glutamate binding and activation", "CREB1 phosphorylation through the activation of Adenylate Cyclase", "CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "Ras activation upon Ca2+ influx through NMDA receptor", "Smooth Muscle Contraction", "Smooth Muscle Contraction", "Activation of Ca-permeable Kainate Receptor", "Uptake and function of anthrax toxins", "VEGFR2 mediated vascular permeability", "VEGFR2 mediated cell proliferation", "Phase 0 - rapid depolarisation", "Ion homeostasis", "CLEC7A (Dectin-1) induces NFAT activation", "CLEC7A (Dectin-1) induces NFAT activation", "RHO GTPases activate IQGAPs", "RHO GTPases activate PAKs", "RHO GTPases activate PAKs", "RAF activation", "RAF/MAP kinase cascade", "Signaling by moderate kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF", "Glycogen breakdown (glycogenolysis)", "Glycogen breakdown (glycogenolysis)", "Protein methylation", "Loss of phosphorylation of MECP2 at T308", "Regulation of MECP2 expression and activity", "Ion transport by P-type ATPases", "Negative regulation of NMDA receptor-mediated neuronal transmission", "Activation of RAC1 downstream of NMDARs", "Activation of RAC1 downstream of NMDARs", "Activation of AMPK downstream of NMDARs", "Long-term potentiation", "Long-term potentiation", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P0DP73": ["Beta defensins", "Defensins"], "P0DP74": ["Beta defensins", "Defensins"], "P0DPB5": ["Cytosolic sensors of pathogen-associated DNA ", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase III Chain Elongation", "RNA Polymerase I Transcription Termination", "RNA Polymerase III Transcription Termination", "RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "P0DPD6": ["Peptide ligand-binding receptors"], "P0DPH7": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "Gap junction assembly", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Recruitment of NuMA to mitotic centrosomes", "Prefoldin mediated transfer of substrate to CCT/TriC", "Formation of tubulin folding intermediates by CCT/TriC", "Post-chaperonin tubulin folding pathway", "Recycling pathway of L1", "Recycling pathway of L1", "Hedgehog 'off' state", "Cilium Assembly", "Intraflagellar transport", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "Carboxyterminal post-translational modifications of tubulin", "Carboxyterminal post-translational modifications of tubulin", "Activation of AMPK downstream of NMDARs", "Kinesins"], "P0DPH8": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "Gap junction assembly", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Recruitment of NuMA to mitotic centrosomes", "Prefoldin mediated transfer of substrate to CCT/TriC", "Formation of tubulin folding intermediates by CCT/TriC", "Post-chaperonin tubulin folding pathway", "Recycling pathway of L1", "Recycling pathway of L1", "Hedgehog 'off' state", "Cilium Assembly", "Intraflagellar transport", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "Carboxyterminal post-translational modifications of tubulin", "Carboxyterminal post-translational modifications of tubulin", "Activation of AMPK downstream of NMDARs", "Kinesins"], "P0DPI0": ["Toxicity of botulinum toxin type A (BoNT/A)"], "P10070": ["Degradation of GLI2 by the proteasome", "Hedgehog 'off' state", "Hedgehog 'on' state", "GLI proteins bind promoters of Hh responsive genes to promote transcription", "RUNX2 regulates chondrocyte maturation"], "P10071": ["GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'off' state", "Hedgehog 'on' state", "GLI proteins bind promoters of Hh responsive genes to promote transcription", "RUNX2 regulates osteoblast differentiation"], "P10072": ["Generic Transcription Pathway"], "P10082": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "P10092": ["G alpha (s) signalling events", "Calcitonin-like ligand receptors"], "P10109": ["Mitochondrial iron-sulfur cluster biogenesis", "Pregnenolone biosynthesis", "Endogenous sterols", "Electron transport from NADPH to Ferredoxin", "Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)"], "P10124": ["Platelet degranulation "], "P10144": ["NOTCH2 intracellular domain regulates transcription", "Activation, myristolyation of BID and translocation to mitochondria"], "P10145": ["Senescence-Associated Secretory Phenotype (SASP)", "Peptide ligand-binding receptors", "Chemokine receptors bind chemokines", "ATF4 activates genes", "G alpha (i) signalling events", "Interleukin-10 signaling", "Interleukin-4 and Interleukin-13 signaling"], "P10147": ["Interleukin-10 signaling"], "P10153": ["Neutrophil degranulation"], "P10176": ["TP53 Regulates Metabolic Genes", "Respiratory electron transport"], "P10242": ["RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Factors involved in megakaryocyte development and platelet production"], "P10243": ["PIWI-interacting RNA (piRNA) biogenesis"], "P10244": ["Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1", "Polo-like kinase mediated events", "TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation"], "P10253": ["Glycogen storage disease type II (GAA)", "Neutrophil degranulation", "Glycogen breakdown (glycogenolysis)"], "P10275": ["HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Nuclear Receptor transcription pathway", "SUMOylation of intracellular receptors", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Ub-specific processing proteases", "RUNX2 regulates osteoblast differentiation", "RUNX2 regulates osteoblast differentiation"], "P10276": ["Nuclear Receptor transcription pathway", "SUMOylation of intracellular receptors", "Signaling by Retinoic Acid", "Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "P10301": ["SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "Sema4D mediated inhibition of cell attachment and migration"], "P10314": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P10316": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P10319": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P10321": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P10323": ["Acrosome Reaction"], "P10398": ["RAF activation", "MAP2K and MAPK activation", "Negative regulation of MAPK pathway", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF"], "P10412": ["Activation of DNA fragmentation factor", "Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "P10415": ["Activation of BAD and translocation to mitochondria ", "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "Interleukin-4 and Interleukin-13 signaling", "The NLRP1 inflammasome", "Estrogen-dependent gene expression"], "P10451": ["Degradation of the extracellular matrix", "Signaling by PDGF", "Integrin cell surface interactions", "Integrin cell surface interactions", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "RUNX3 Regulates Immune Response and Cell Migration", "Post-translational protein phosphorylation"], "P10515": ["Regulation of pyruvate dehydrogenase (PDH) complex", "Glyoxylate metabolism and glycine degradation", "Signaling by Retinoic Acid", "Pyruvate metabolism"], "P10523": ["Activation of the phototransduction cascade", "Inactivation, recovery and regulation of the phototransduction cascade", "Inactivation, recovery and regulation of the phototransduction cascade"], "P10586": ["Receptor-type tyrosine-protein phosphatases", "Synaptic adhesion-like molecules"], "P10588": ["Nuclear Receptor transcription pathway"], "P10589": ["Nuclear Receptor transcription pathway"], "P10599": ["Oxidative Stress Induced Senescence", "Detoxification of Reactive Oxygen Species", "Interconversion of nucleotide di- and triphosphates", "TP53 Regulates Metabolic Genes", "Protein repair", "The NLRP3 inflammasome", "The NLRP3 inflammasome", "Regulation of FOXO transcriptional activity by acetylation"], "P10600": ["Platelet degranulation ", "Molecules associated with elastic fibres", "ECM proteoglycans"], "P10606": ["TP53 Regulates Metabolic Genes", "Respiratory electron transport"], "P10619": ["Glycosphingolipid metabolism", "MHC class II antigen presentation", "Sialic acid metabolism", "Neutrophil degranulation"], "P10620": ["Glutathione conjugation", "Aflatoxin activation and detoxification", "Neutrophil degranulation"], "P10632": ["Xenobiotics", "CYP2E1 reactions", "Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)", "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)", "Biosynthesis of maresin-like SPMs"], "P10635": ["Fatty acids", "Miscellaneous substrates", "Xenobiotics", "CYP2E1 reactions", "Biosynthesis of maresin-like SPMs"], "P10636": ["Caspase-mediated cleavage of cytoskeletal proteins"], "P10636-8": ["Activation of AMPK downstream of NMDARs"], "P10643": ["Terminal pathway of complement", "Regulation of Complement cascade"], "P10644": ["PKA activation", "PKA activation in glucagon signalling", "DARPP-32 events", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Vasopressin regulates renal water homeostasis via Aquaporins", "CREB1 phosphorylation through the activation of Adenylate Cyclase", "Hedgehog 'off' state", "Factors involved in megakaryocyte development and platelet production"], "P10645": ["Antimicrobial peptides"], "P10646": ["Extrinsic Pathway of Fibrin Clot Formation"], "P10696": ["Post-translational modification: synthesis of GPI-anchored proteins"], "P10720": ["Common Pathway of Fibrin Clot Formation", "Cell surface interactions at the vascular wall"], "P10721": ["PIP3 activates AKT signaling", "Signaling by SCF-KIT", "Signaling by SCF-KIT", "Regulation of KIT signaling", "Regulation of KIT signaling", "Constitutive Signaling by Aberrant PI3K in Cancer", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "TFAP2 (AP-2) family regulates transcription of growth factors and their receptors"], "P10745": ["The retinoid cycle in cones (daylight vision)", "The canonical retinoid cycle in rods (twilight vision)"], "P10746": ["Heme biosynthesis"], "P10747": ["PIP3 activates AKT signaling", "Nef mediated downregulation of CD28 cell surface expression", "Constitutive Signaling by Aberrant PI3K in Cancer", "CD28 co-stimulation", "CD28 dependent PI3K/Akt signaling", "CD28 dependent Vav1 pathway", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "P10767": ["PI3K Cascade", "PIP3 activates AKT signaling", "Signaling by activated point mutants of FGFR1", "FGFR4 ligand binding and activation", "FGFR1c ligand binding and activation", "FGFR2c ligand binding and activation", "Activated point mutants of FGFR2", "Constitutive Signaling by Aberrant PI3K in Cancer", "Phospholipase C-mediated cascade: FGFR1", "Phospholipase C-mediated cascade; FGFR2", "Phospholipase C-mediated cascade; FGFR4", "Downstream signaling of activated FGFR1", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "PI-3K cascade:FGFR4", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR4 signaling", "Signaling by FGFR2 in disease", "Signaling by FGFR1 in disease", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "P10768": ["Glutathione conjugation"], "P10809": ["Mitochondrial protein import", "Mitochondrial protein import", "TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation"], "P10826": ["Nuclear Receptor transcription pathway", "Signaling by Retinoic Acid", "Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "P10827": ["Nuclear Receptor transcription pathway"], "P10827-2": ["SUMOylation of intracellular receptors"], "P10828": ["Nuclear Receptor transcription pathway", "SUMOylation of intracellular receptors"], "P10844": ["Toxicity of botulinum toxin type B (BoNT/B)"], "P10909": ["Platelet degranulation ", "Terminal pathway of complement", "Antimicrobial peptides", "Regulation of Complement cascade"], "P10911": ["Axonal growth inhibition (RHOA activation)", "NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "P10912": ["Prolactin receptor signaling", "Growth hormone receptor signaling", "Growth hormone receptor signaling"], "P10914": ["Interferon gamma signaling", "Interferon alpha/beta signaling", "Factors involved in megakaryocyte development and platelet production"], "P10915": ["ECM proteoglycans"], "P10916": ["Striated Muscle Contraction"], "P10966": ["Nef Mediated CD8 Down-regulation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "P10997": ["Regulation of gene expression in beta cells", "G alpha (s) signalling events", "Calcitonin-like ligand receptors", "Amyloid fiber formation"], "P11021": ["Platelet degranulation ", "Regulation of HSF1-mediated heat shock response", "ATF6 (ATF6-alpha) activates chaperones", "PERK regulates gene expression", "IRE1alpha activates chaperones", "ATF6 (ATF6-alpha) activates chaperone genes", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P11047": ["Degradation of the extracellular matrix", "Laminin interactions", "Laminin interactions", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "L1CAM interactions", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "MET activates PTK2 signaling", "Post-translational protein phosphorylation"], "P11055": ["Striated Muscle Contraction"], "P11086": ["Catecholamine biosynthesis"], "P11142": ["Regulation of HSF1-mediated heat shock response", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Attenuation phase", "HSF1-dependent transactivation", "Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis", "CHL1 interactions", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Interleukin-4 and Interleukin-13 signaling", "Neutrophil degranulation", "mRNA Splicing - Major Pathway", "Clathrin-mediated endocytosis", "Protein methylation", "GABA synthesis, release, reuptake and degradation"], "P11150": ["Assembly of active LPL and LIPC lipase complexes", "Chylomicron clearance"], "P11161": ["Transcriptional regulation of white adipocyte differentiation", "Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "P11166": ["Cellular hexose transport", "Vitamin C (ascorbate) metabolism", "Regulation of insulin secretion", "Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1)", "Lactose synthesis"], "P11168": ["Cellular hexose transport", "Regulation of gene expression in beta cells", "Regulation of insulin secretion", "Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS)", "Intestinal hexose absorption"], "P11169": ["Cellular hexose transport", "Vitamin C (ascorbate) metabolism", "Neutrophil degranulation", "MECP2 regulates neuronal receptors and channels"], "P11171": ["Neurexins and neuroligins"], "P11172": ["Pyrimidine biosynthesis"], "P11177": ["Regulation of pyruvate dehydrogenase (PDH) complex", "Glyoxylate metabolism and glycine degradation", "Signaling by Retinoic Acid", "Pyruvate metabolism"], "P11182": ["Glyoxylate metabolism and glycine degradation", "Branched-chain amino acid catabolism"], "P11215": ["Toll Like Receptor 4 (TLR4) Cascade", "Cell surface interactions at the vascular wall", "Integrin cell surface interactions", "Interleukin-4 and Interleukin-13 signaling", "Neutrophil degranulation"], "P11216": ["Neutrophil degranulation", "Glycogen breakdown (glycogenolysis)"], "P11217": ["Glycogen breakdown (glycogenolysis)", "Glycogen breakdown (glycogenolysis)"], "P11226": ["Lectin pathway of complement activation", "Initial triggering of complement"], "P11229": ["Muscarinic acetylcholine receptors", "G alpha (q) signalling events"], "P11233": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "p38MAPK events", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "P11234": ["p38MAPK events"], "P11245": ["Acetylation"], "P11274": ["Signaling by cytosolic FGFR1 fusion mutants", "Rho GTPase cycle", "Signaling by FGFR1 in disease"], "P11277": ["NCAM signaling for neurite out-growth", "NCAM signaling for neurite out-growth", "Interaction between L1 and Ankyrins", "Interaction between L1 and Ankyrins", "RAF/MAP kinase cascade", "COPI-mediated anterograde transport"], "P11279": ["Neutrophil degranulation"], "P11296": ["Cell surface interactions at the vascular wall"], "P11297": ["Cell surface interactions at the vascular wall"], "P11309": ["Interleukin-4 and Interleukin-13 signaling"], "P11310": ["PPARA activates gene expression", "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids", "Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "Beta oxidation of octanoyl-CoA to hexanoyl-CoA"], "P11362": ["Signaling by activated point mutants of FGFR1", "Signaling by FGFR1 in disease", "Signaling by plasma membrane FGFR1 fusions"], "P11362-1": ["PI3K Cascade", "PIP3 activates AKT signaling", "Signaling by FGFR1 amplification mutants", "Signaling by activated point mutants of FGFR1", "FGFR1c ligand binding and activation", "FGFR1c and Klotho ligand binding and activation", "Constitutive Signaling by Aberrant PI3K in Cancer", "NCAM signaling for neurite out-growth", "Signal transduction by L1", "Phospholipase C-mediated cascade: FGFR1", "Downstream signaling of activated FGFR1", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "Negative regulation of FGFR1 signaling", "Signaling by FGFR1 in disease", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "P11362-19": ["PI3K Cascade", "PIP3 activates AKT signaling", "Signaling by FGFR1 amplification mutants", "FGFR1b ligand binding and activation", "Constitutive Signaling by Aberrant PI3K in Cancer", "Phospholipase C-mediated cascade: FGFR1", "Downstream signaling of activated FGFR1", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "Negative regulation of FGFR1 signaling", "Signaling by FGFR1 in disease", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "P11387": ["SUMOylation of DNA replication proteins"], "P11388": ["Transcription of E2F targets under negative control by DREAM complex", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins"], "P11413": ["TP53 Regulates Metabolic Genes", "Pentose phosphate pathway"], "P11464": ["Cell surface interactions at the vascular wall"], "P11465": ["Cell surface interactions at the vascular wall"], "P11473": ["Vitamin D (calciferol) metabolism", "Nuclear Receptor transcription pathway", "SUMOylation of intracellular receptors"], "P11474": ["PPARA activates gene expression", "Transcriptional activation of mitochondrial biogenesis", "Transcriptional activation of mitochondrial biogenesis", "Nuclear Receptor transcription pathway", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity"], "P11487": ["PI3K Cascade", "PIP3 activates AKT signaling", "FGFR1b ligand binding and activation", "FGFR2b ligand binding and activation", "Activated point mutants of FGFR2", "Constitutive Signaling by Aberrant PI3K in Cancer", "Phospholipase C-mediated cascade: FGFR1", "Phospholipase C-mediated cascade; FGFR2", "Downstream signaling of activated FGFR1", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Signaling by FGFR2 in disease", "FGFRL1 modulation of FGFR1 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "P11488": ["PLC beta mediated events", "PLC beta mediated events", "G-protein activation", "Activation of the phototransduction cascade", "Activation of the phototransduction cascade", "Inactivation, recovery and regulation of the phototransduction cascade", "Inactivation, recovery and regulation of the phototransduction cascade", "G alpha (i) signalling events", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "P11498": ["Biotin transport and metabolism", "Defective HLCS causes multiple carboxylase deficiency", "Gluconeogenesis"], "P11509": ["Xenobiotics", "CYP2E1 reactions"], "P11511": ["Estrogen biosynthesis", "Endogenous sterols", "Defective CYP19A1 causes Aromatase excess syndrome (AEXS)"], "P11532": ["Non-integrin membrane-ECM interactions", "Striated Muscle Contraction"], "P11586": ["Metabolism of folate and pterines"], "P11597": ["LDL remodeling", "HDL remodeling"], "P11678": ["Neutrophil degranulation"], "P11686": ["Surfactant metabolism", "Defective pro-SFTPC causes pulmonary surfactant metabolism dysfunction 2 (SMDP2) and respiratory distress syndrome (RDS)", "Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5)", "Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)"], "P11712": ["Xenobiotics", "CYP2E1 reactions", "Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)", "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)", "Biosynthesis of maresin-like SPMs"], "P11717": ["Golgi Associated Vesicle Biogenesis", "Neutrophil degranulation", "Retrograde transport at the Trans-Golgi-Network", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "P11766": ["Ethanol oxidation"], "P11802": ["SCF(Skp2)-mediated degradation of p27/p21", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "Oncogene Induced Senescence", "RMTs methylate histone arginines", "Transcriptional regulation of white adipocyte differentiation", "Ubiquitin-dependent degradation of Cyclin D1", "Ubiquitin-dependent degradation of Cyclin D1", "Cyclin D associated events in G1", "PTK6 Regulates Cell Cycle", "Transcriptional regulation by RUNX2", "Meiotic recombination"], "P11831": ["RHO GTPases Activate Formins"], "P11908": ["5-Phosphoribose 1-diphosphate biosynthesis"], "P11912": ["CD22 mediated BCR regulation", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P11926": ["Regulation of ornithine decarboxylase (ODC)", "Metabolism of polyamines"], "P11940": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Deadenylation of mRNA", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Translation initiation complex formation", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P12004": ["Translesion synthesis by REV1", "Recognition of DNA damage by PCNA-containing replication complex", "Translesion Synthesis by POLH", "Transcription of E2F targets under negative control by DREAM complex", "Polymerase switching on the C-strand of the telomere", "Processive synthesis on the C-strand of the telomere", "Telomere C-strand (Lagging Strand) Synthesis", "Removal of the Flap Intermediate from the C-strand", "SUMOylation of DNA replication proteins", "Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "Activation of E2F1 target genes at G1/S", "PCNA-Dependent Long Patch Base Excision Repair", "Translesion synthesis by POLK", "Translesion synthesis by POLI", "Termination of translesion DNA synthesis", "HDR through Homologous Recombination (HRR)", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "Polymerase switching", "Removal of the Flap Intermediate", "Processive synthesis on the lagging strand", "E3 ubiquitin ligases ubiquitinate target proteins"], "P12018": ["Cell surface interactions at the vascular wall"], "P12034-1": ["PI3K Cascade", "PIP3 activates AKT signaling", "Signaling by activated point mutants of FGFR1", "Signaling by activated point mutants of FGFR3", "FGFR3c ligand binding and activation", "FGFR1c ligand binding and activation", "FGFR2c ligand binding and activation", "FGFR3 mutant receptor activation", "Activated point mutants of FGFR2", "Constitutive Signaling by Aberrant PI3K in Cancer", "Phospholipase C-mediated cascade: FGFR1", "Phospholipase C-mediated cascade; FGFR2", "Phospholipase C-mediated cascade; FGFR3", "Downstream signaling of activated FGFR1", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "PI-3K cascade:FGFR3", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Signaling by FGFR2 in disease", "Signaling by FGFR1 in disease", "FGFRL1 modulation of FGFR1 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Signaling by FGFR3 point mutants in cancer"], "P12035": ["Keratinization", "Formation of the cornified envelope"], "P12074": ["TP53 Regulates Metabolic Genes", "Respiratory electron transport"], "P12081": ["Cytosolic tRNA aminoacylation"], "P12104": ["Triglyceride catabolism"], "P12107": ["Collagen degradation", "Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Assembly of collagen fibrils and other multimeric structures", "Non-integrin membrane-ECM interactions", "MET activates PTK2 signaling", "Collagen chain trimerization"], "P12109": ["Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Signaling by PDGF", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "ECM proteoglycans", "ECM proteoglycans", "NCAM1 interactions", "Collagen chain trimerization"], "P12110": ["Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Signaling by PDGF", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "ECM proteoglycans", "ECM proteoglycans", "NCAM1 interactions", "Collagen chain trimerization"], "P12111": ["Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Signaling by PDGF", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "ECM proteoglycans", "ECM proteoglycans", "NCAM1 interactions", "Collagen chain trimerization"], "P12235": ["Mitochondrial protein import", "Mitochondrial protein import", "Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization", "Regulation of insulin secretion"], "P12236": ["Mitochondrial protein import", "Mitochondrial protein import", "Influenza Virus Induced Apoptosis", "Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization", "Regulation of insulin secretion"], "P12259": ["Platelet degranulation ", "Common Pathway of Fibrin Clot Formation", "COPII-mediated vesicle transport", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Cargo concentration in the ER", "Post-translational protein phosphorylation"], "P12268": ["Neutrophil degranulation", "Purine ribonucleoside monophosphate biosynthesis"], "P12270": ["ISG15 antiviral mechanism", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)", "tRNA processing in the nucleus"], "P12271": ["The retinoid cycle in cones (daylight vision)", "The retinoid cycle in cones (daylight vision)", "Retinoid cycle disease events", "The canonical retinoid cycle in rods (twilight vision)"], "P12272": ["Class B/2 (Secretin family receptors)", "G alpha (s) signalling events"], "P12273": ["Miscellaneous transport and binding events"], "P12277": ["Creatine metabolism"], "P12314": ["Cross-presentation of soluble exogenous antigens (endosomes)", "Cross-presentation of soluble exogenous antigens (endosomes)", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Interferon gamma signaling"], "P12318": ["FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Neutrophil degranulation"], "P12319": ["Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation"], "P12487": ["Dectin-2 family"], "P12488": ["Dectin-2 family"], "P12489": ["Dectin-2 family"], "P12490": ["Dectin-2 family"], "P12491": ["Dectin-2 family"], "P12493": ["ISG15 antiviral mechanism"], "P12532": ["Creatine metabolism"], "P12643": ["Signaling by BMP", "Molecules associated with elastic fibres", "Transcriptional regulation by RUNX2", "Regulation of RUNX2 expression and activity"], "P12644": ["Molecules associated with elastic fibres", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "P12694": ["Glyoxylate metabolism and glycine degradation", "Branched-chain amino acid catabolism"], "P12724": ["Neutrophil degranulation", "Antimicrobial peptides"], "P12755": ["Signaling by BMP", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "Downregulation of SMAD2/3:SMAD4 transcriptional activity"], "P12757": ["Downregulation of SMAD2/3:SMAD4 transcriptional activity", "Downregulation of SMAD2/3:SMAD4 transcriptional activity"], "P12814": ["Platelet degranulation ", "Syndecan interactions", "Nephrin family interactions", "Regulation of cytoskeletal remodeling and cell spreading by IPP complex components"], "P12821": ["Metabolism of Angiotensinogen to Angiotensins"], "P12829": ["Striated Muscle Contraction"], "P12830": ["Degradation of the extracellular matrix", "Degradation of the extracellular matrix", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Integrin cell surface interactions", "Apoptotic cleavage of cell adhesion proteins", "Adherens junctions interactions", "RHO GTPases activate IQGAPs", "InlA-mediated entry of Listeria monocytogenes into host cells"], "P12838": ["Defensins", "Alpha-defensins", "Neutrophil degranulation"], "P12872": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "P12931": ["Signaling by ERBB2", "Nuclear signaling by ERBB4", "PIP3 activates AKT signaling", "GAB1 signalosome", "Downstream signal transduction", "Constitutive Signaling by Aberrant PI3K in Cancer", "Integrin alphaIIb beta3 signaling", "GRB2:SOS provides linkage to MAPK signaling for Integrins ", "p130Cas linkage to MAPK signaling for integrins", "G alpha (s) signalling events", "G alpha (i) signalling events", "DCC mediated attractive signaling", "DCC mediated attractive signaling", "Netrin mediated repulsion signals", "Regulation of commissural axon pathfinding by SLIT and ROBO", "RAF activation", "MAP2K and MAPK activation", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "MET activates PTK2 signaling", "InlA-mediated entry of Listeria monocytogenes into host cells", "Regulation of RUNX1 Expression and Activity", "RUNX2 regulates osteoblast differentiation", "Regulation of RUNX3 expression and activity", "Activated NTRK2 signals through FYN", "Activated NTRK3 signals through PI3K", "Activated NTRK3 signals through PI3K", "Long-term potentiation"], "P12931-1": ["Spry regulation of FGF signaling", "Signaling by SCF-KIT", "Signaling by SCF-KIT", "Regulation of KIT signaling", "p38MAPK events", "Signaling by EGFR", "FCGR activation", "PECAM1 interactions", "EPH-Ephrin signaling", "Integrin alphaIIb beta3 signaling", "NCAM signaling for neurite out-growth", "CD28 co-stimulation", "CTLA4 inhibitory signaling", "Signal regulatory protein family interactions", "EPHB-mediated forward signaling", "EPHB-mediated forward signaling", "EPHA-mediated growth cone collapse", "EPHA-mediated growth cone collapse", "Ephrin signaling", "Ephrin signaling", "EPH-ephrin mediated repulsion of cells", "ADP signalling through P2Y purinoceptor 1", "GP1b-IX-V activation signalling", "Recycling pathway of L1", "VEGFA-VEGFR2 Pathway", "VEGFA-VEGFR2 Pathway", "Thrombin signalling through proteinase activated receptors (PARs)", "VEGFR2 mediated cell proliferation", "CLEC7A (Dectin-1) signaling", "RHO GTPases Activate Formins", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Cyclin D associated events in G1", "RET signaling", "Receptor Mediated Mitophagy"], "P12931-2": ["c-src mediated regulation of Cx43 function and closure of gap junctions"], "P12956": ["2-LTR circle formation", "Cytosolic sensors of pathogen-associated DNA ", "IRF3-mediated induction of type I IFN", "Nonhomologous End-Joining (NHEJ)", "Neutrophil degranulation"], "P13010": ["2-LTR circle formation", "Cytosolic sensors of pathogen-associated DNA ", "IRF3-mediated induction of type I IFN", "Nonhomologous End-Joining (NHEJ)", "Neutrophil degranulation"], "P13051-1": ["Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "Cleavage of the damaged pyrimidine ", "Displacement of DNA glycosylase by APEX1"], "P13056": ["Nuclear Receptor transcription pathway", "SUMOylation of intracellular receptors"], "P13073": ["TP53 Regulates Metabolic Genes", "Respiratory electron transport"], "P13164": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon alpha/beta signaling"], "P13196": ["Heme biosynthesis", "PPARA activates gene expression", "Transcriptional activation of mitochondrial biogenesis"], "P13224": ["Intrinsic Pathway of Fibrin Clot Formation", "GP1b-IX-V activation signalling", "Platelet Adhesion to exposed collagen", "Platelet Aggregation (Plug Formation)"], "P13232": ["Interleukin-7 signaling", "Interleukin-7 signaling"], "P13236": ["G alpha (i) signalling events", "Interleukin-10 signaling"], "P13284": ["MHC class II antigen presentation", "Interferon gamma signaling"], "P13349": ["CDO in myogenesis", "CDO in myogenesis"], "P13385": ["Signaling by NODAL", "Regulation of signaling by NODAL", "POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation"], "P13423": ["Uptake and function of anthrax toxins"], "P13473": ["Platelet degranulation ", "Neutrophil degranulation"], "P13497": ["Degradation of the extracellular matrix", "Degradation of the extracellular matrix", "Collagen biosynthesis and modifying enzymes", "Anchoring fibril formation", "Crosslinking of collagen fibrils"], "P13497-3": ["HDL assembly"], "P13498": ["ROS, RNS production in phagocytes", "Cross-presentation of particulate exogenous antigens (phagosomes)", "Detoxification of Reactive Oxygen Species", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate NADPH Oxidases", "Neutrophil degranulation"], "P13500": ["ATF4 activates genes", "Interleukin-10 signaling", "Interleukin-4 and Interleukin-13 signaling"], "P13501": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events", "Interleukin-10 signaling"], "P13521": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "P13533": ["Striated Muscle Contraction"], "P13535": ["Striated Muscle Contraction"], "P13569": ["ABC-family proteins mediated transport", "RHO GTPases regulate CFTR trafficking", "Defective CFTR causes cystic fibrosis", "Ub-specific processing proteases", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "P13584": ["Fatty acids", "Miscellaneous substrates", "Eicosanoids", "Synthesis of Leukotrienes (LT) and Eoxins (EX)"], "P13591": ["ECM proteoglycans", "NCAM signaling for neurite out-growth", "NCAM signaling for neurite out-growth", "NCAM1 interactions", "NCAM1 interactions", "Signal transduction by L1", "RAF/MAP kinase cascade", "Interferon gamma signaling"], "P13598": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Integrin cell surface interactions", "CD209 (DC-SIGN) signaling"], "P13611": ["A tetrasaccharide linker sequence is required for GAG synthesis", "Chondroitin sulfate biosynthesis", "Dermatan sulfate biosynthesis", "CS/DS degradation", "ECM proteoglycans", "Defective B4GALT7 causes EDS, progeroid type", "Defective B3GAT3 causes JDSSDHD", "Defective CHST3 causes SEDCJD", "Defective CHST14 causes EDS, musculocontractural type", "Defective CHSY1 causes TPBS", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Defective B3GALT6 causes EDSP2 and SEMDJL1", "Post-translational protein phosphorylation"], "P13612": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "Integrin cell surface interactions", "Integrin cell surface interactions", "RUNX3 Regulates Immune Response and Cell Migration"], "P13631": ["Nuclear Receptor transcription pathway", "Signaling by Retinoic Acid", "Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "P13637": ["Ion homeostasis", "Ion transport by P-type ATPases"], "P13639": ["Peptide chain elongation", "Peptide chain elongation", "Uptake and function of diphtheria toxin", "Synthesis of diphthamide-EEF2", "Synthesis of diphthamide-EEF2", "Neutrophil degranulation", "Protein methylation"], "P13640": ["Metallothioneins bind metals"], "P13645": ["Keratinization", "Formation of the cornified envelope"], "P13646": ["Keratinization", "Formation of the cornified envelope"], "P13647": ["Type I hemidesmosome assembly", "Keratinization", "Formation of the cornified envelope"], "P13671": ["Terminal pathway of complement", "Regulation of Complement cascade"], "P13674": ["Collagen biosynthesis and modifying enzymes"], "P13686": ["Vitamin B2 (riboflavin) metabolism"], "P13688": ["Fibronectin matrix formation", "Cell surface interactions at the vascular wall", "Neutrophil degranulation"], "P13716": ["Heme biosynthesis", "Neutrophil degranulation"], "P13725": ["Interleukin-4 and Interleukin-13 signaling", "IL-6-type cytokine receptor ligand interactions"], "P13726": ["Extrinsic Pathway of Fibrin Clot Formation"], "P13727": ["Neutrophil degranulation"], "P13746": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P13747": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "DAP12 interactions", "DAP12 signaling", "DAP12 signaling", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P13760": ["Downstream TCR signaling", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "MHC class II antigen presentation", "PD-1 signaling", "Interferon gamma signaling"], "P13761": ["Downstream TCR signaling", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "MHC class II antigen presentation", "PD-1 signaling", "Interferon gamma signaling"], "P13762": ["Downstream TCR signaling", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "MHC class II antigen presentation", "PD-1 signaling", "Interferon gamma signaling"], "P13765": ["MHC class II antigen presentation"], "P13796": ["Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "P13798": ["Neutrophil degranulation", "Eukaryotic Translation Termination"], "P13804": ["Respiratory electron transport"], "P13805": ["Striated Muscle Contraction"], "P13807": ["Glycogen synthesis", "Myoclonic epilepsy of Lafora", "Glycogen storage disease type XV (GYG1)", "Glycogen storage disease type 0 (muscle GYS1)"], "P13861": ["PKA activation", "PKA activation in glucagon signalling", "DARPP-32 events", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Vasopressin regulates renal water homeostasis via Aquaporins", "CREB1 phosphorylation through the activation of Adenylate Cyclase", "Hedgehog 'off' state", "ROBO receptors bind AKAP5", "Factors involved in megakaryocyte development and platelet production"], "P13866": ["Cellular hexose transport", "Defective SLC5A1 causes congenital glucose/galactose malabsorption (GGM)", "Intestinal hexose absorption"], "P13929": ["Glycolysis", "Gluconeogenesis"], "P13942": ["Collagen degradation", "Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Assembly of collagen fibrils and other multimeric structures", "Non-integrin membrane-ECM interactions", "MET activates PTK2 signaling", "Collagen chain trimerization"], "P13945": ["Adrenoceptors", "G alpha (s) signalling events"], "P13984": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Abortive elongation of HIV-1 transcript in the absence of Tat", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "Viral Messenger RNA Synthesis", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE", "Signaling by FGFR2 IIIa TM", "Estrogen-dependent gene expression"], "P13987": ["COPII-mediated vesicle transport", "Cargo concentration in the ER", "Neutrophil degranulation", "COPI-mediated anterograde transport", "Regulation of Complement cascade"], "P13995": ["Metabolism of folate and pterines"], "P14060": ["Androgen biosynthesis", "Mineralocorticoid biosynthesis", "Glucocorticoid biosynthesis"], "P14061": ["Estrogen biosynthesis", "The canonical retinoid cycle in rods (twilight vision)"], "P14091": ["MHC class II antigen presentation"], "P14136": ["Nuclear signaling by ERBB4"], "P14138": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "P14151": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "Neutrophil degranulation"], "P14174": ["Cell surface interactions at the vascular wall", "Neutrophil degranulation", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "P14207": ["Post-translational modification: synthesis of GPI-anchored proteins", "Metabolism of folate and pterines"], "P14209": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall"], "P14210": ["Platelet degranulation ", "PIP3 activates AKT signaling", "Interleukin-7 signaling", "Constitutive Signaling by Aberrant PI3K in Cancer", "RAF/MAP kinase cascade", "Interleukin-4 and Interleukin-13 signaling", "MET Receptor Activation", "Negative regulation of MET activity", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "MET activates RAS signaling", "MET activates PI3K/AKT signaling", "MET activates PTPN11", "MET activates PTK2 signaling", "MET interacts with TNS proteins", "MET activates RAP1 and RAC1", "MET receptor recycling", "MET activates STAT3"], "P14314": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "Advanced glycosylation endproduct receptor signaling", "Post-translational protein phosphorylation", "Calnexin/calreticulin cycle"], "P14316": ["Interferon gamma signaling", "Interferon alpha/beta signaling", "Factors involved in megakaryocyte development and platelet production"], "P14324": ["Cholesterol biosynthesis", "Activation of gene expression by SREBF (SREBP)"], "P14373": ["SUMOylation of ubiquitinylation proteins", "Regulation of PTEN stability and activity"], "P14384": ["Post-translational modification: synthesis of GPI-anchored proteins"], "P14410": ["Digestion of dietary carbohydrate", "Intestinal saccharidase deficiencies", "Intestinal saccharidase deficiencies"], "P14415": ["Basigin interactions", "Ion homeostasis", "Ion transport by P-type ATPases"], "P14416": ["Dopamine receptors", "G alpha (i) signalling events"], "P14543": ["Degradation of the extracellular matrix", "Degradation of the extracellular matrix", "Laminin interactions", "Laminin interactions"], "P14550": ["Glutathione conjugation", "Formation of xylulose-5-phosphate"], "P14555": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PS", "Acyl chain remodelling of PE", "Acyl chain remodelling of PI", "Acyl chain remodelling of PG", "Synthesis of PA", "Antimicrobial peptides"], "P14598": ["ROS, RNS production in phagocytes", "Cross-presentation of particulate exogenous antigens (phagosomes)", "Detoxification of Reactive Oxygen Species", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate NADPH Oxidases"], "P14618": ["Neutrophil degranulation"], "P14618-1": ["Glycolysis"], "P14618-2": ["Glycolysis"], "P14625": ["Trafficking and processing of endosomal TLR", "Scavenging by Class A Receptors", "Scavenging by Class A Receptors", "ATF6 (ATF6-alpha) activates chaperone genes", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Interleukin-4 and Interleukin-13 signaling", "Post-translational protein phosphorylation"], "P14635": ["E2F-enabled inhibition of pre-replication complex formation", "Polo-like kinase mediated events", "Golgi Cisternae Pericentriolar Stack Reorganization", "APC/C:Cdc20 mediated degradation of Cyclin B", "Regulation of APC/C activators between G1/S and early anaphase", "Phosphorylation of the APC/C", "Phosphorylation of Emi1", "Condensation of Prophase Chromosomes", "MASTL Facilitates Mitotic Progression", "Resolution of Sister Chromatid Cohesion", "Condensation of Prometaphase Chromosomes", "Regulation of PLK1 Activity at G2/M Transition", "Activation of NIMA Kinases NEK9, NEK6, NEK7", "Nuclear Pore Complex (NPC) Disassembly", "Depolymerisation of the Nuclear Lamina", "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "Mitotic Prophase", "Cyclin A/B1/B2 associated events during G2/M transition", "G2/M DNA replication checkpoint", "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "The role of GTSE1 in G2/M progression after G2 checkpoint", "Transcriptional regulation by RUNX2"], "P14649": ["Smooth Muscle Contraction"], "P14651": ["Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "P14652": ["Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "P14653": ["Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "P14672": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Cellular hexose transport", "Transcriptional regulation of white adipocyte differentiation"], "P14678": ["Cleavage of Growing Transcript in the Termination Region ", "SLBP independent Processing of Histone Pre-mRNAs", "snRNP Assembly", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"], "P14679": ["Melanin biosynthesis"], "P14735": ["Ub-specific processing proteases", "Peroxisomal protein import", "Peroxisomal protein import"], "P14770": ["Intrinsic Pathway of Fibrin Clot Formation", "GP1b-IX-V activation signalling", "Platelet Adhesion to exposed collagen", "Platelet Aggregation (Plug Formation)"], "P14778": ["Interleukin-10 signaling", "Interleukin-1 signaling"], "P14780": ["Signaling by SCF-KIT", "Collagen degradation", "Collagen degradation", "Degradation of the extracellular matrix", "Degradation of the extracellular matrix", "Activation of Matrix Metalloproteinases", "Assembly of collagen fibrils and other multimeric structures", "EPH-ephrin mediated repulsion of cells", "Interleukin-4 and Interleukin-13 signaling", "Neutrophil degranulation"], "P14784": ["RAF/MAP kinase cascade", "Interleukin-15 signaling", "Interleukin-15 signaling", "Interleukin-2 signaling", "Interleukin receptor SHC signaling"], "P14854": ["TP53 Regulates Metabolic Genes", "Respiratory electron transport"], "P14859": ["Interleukin-4 and Interleukin-13 signaling", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "Estrogen-dependent gene expression"], "P14866": ["mRNA Splicing - Major Pathway", "Processing of Capped Intron-Containing Pre-mRNA"], "P14867": ["GABA A receptor activation", "GABA receptor activation"], "P14868": ["SeMet incorporation into proteins", "Cytosolic tRNA aminoacylation"], "P14902": ["Tryptophan catabolism"], "P14920": ["Glyoxylate metabolism and glycine degradation", "Peroxisomal protein import", "Peroxisomal protein import"], "P14921": ["Oncogene Induced Senescence"], "P14923": ["Adherens junctions interactions", "VEGFR2 mediated vascular permeability", "Neutrophil degranulation", "Keratinization", "Formation of the cornified envelope"], "P14927": ["Respiratory electron transport"], "P15018": ["Interleukin-10 signaling", "Interleukin-4 and Interleukin-13 signaling", "IL-6-type cytokine receptor ligand interactions"], "P15036": ["Oncogene Induced Senescence"], "P15056": ["Spry regulation of FGF signaling", "Frs2-mediated activation", "ARMS-mediated activation", "Signalling to p38 via RIT and RIN", "RAF activation", "MAP2K and MAPK activation", "Negative feedback regulation of MAPK pathway", "Negative regulation of MAPK pathway", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF"], "P15059": ["CASP8 activity is inhibited", "Regulation of TNFR1 signaling"], "P15086": ["Metabolism of Angiotensinogen to Angiotensins"], "P15088": ["Metabolism of Angiotensinogen to Angiotensins"], "P15090": ["Triglyceride catabolism", "Triglyceride catabolism", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "P15104": ["Astrocytic Glutamate-Glutamine Uptake And Metabolism", "Amino acid synthesis and interconversion (transamination)"], "P15121": ["Pregnenolone biosynthesis", "Fructose biosynthesis"], "P15144": ["Metabolism of Angiotensinogen to Angiotensins", "Neutrophil degranulation"], "P15151": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Nectin/Necl trans heterodimerization"], "P15153": ["GPVI-mediated activation cascade", "ROS, RNS production in phagocytes", "PIP3 activates AKT signaling", "Rho GTPase cycle", "Constitutive Signaling by Aberrant PI3K in Cancer", "PCP/CE pathway", "RHO GTPases Activate NADPH Oxidases", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "P15169": ["Regulation of Complement cascade"], "P15170": ["Eukaryotic Translation Termination", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P15172": ["CDO in myogenesis", "CDO in myogenesis"], "P15173": ["CDO in myogenesis", "CDO in myogenesis"], "P15248": ["Interleukin-9 signaling"], "P15259": ["Glycolysis", "Gluconeogenesis"], "P15260": ["Interferon gamma signaling", "Regulation of IFNG signaling", "Regulation of IFNG signaling"], "P15289": ["Glycosphingolipid metabolism", "The activation of arylsulfatases", "Neutrophil degranulation"], "P15291": ["Interaction With The Zona Pellucida", "Pre-NOTCH Processing in Golgi", "Keratan sulfate biosynthesis", "Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)", "Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)", "Lactose synthesis", "Neutrophil degranulation", "N-Glycan antennae elongation"], "P15309": ["Neutrophil degranulation"], "P15311": ["Netrin-1 signaling", "Recycling pathway of L1", "Recycling pathway of L1"], "P15313": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "P15328": ["COPII-mediated vesicle transport", "Cargo concentration in the ER", "COPI-mediated anterograde transport"], "P15336": ["Transcriptional activation of mitochondrial biogenesis", "HATs acetylate histones", "Circadian Clock", "Activation of the AP-1 family of transcription factors", "TP53 Regulates Transcription of DNA Repair Genes", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription", "Estrogen-dependent gene expression"], "P15374": ["UCH proteinases", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Neddylation"], "P15382": ["Phase 3 - rapid repolarisation", "Phase 2 - plateau phase"], "P15391": ["PIP3 activates AKT signaling", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Constitutive Signaling by Aberrant PI3K in Cancer", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P15428": ["Synthesis of Lipoxins (LX)", "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "Biosynthesis of D-series resolvins", "Biosynthesis of E-series 18(S)-resolvins"], "P15498": ["GPVI-mediated activation cascade", "GPVI-mediated activation cascade", "PIP3 activates AKT signaling", "Signaling by SCF-KIT", "NRAGE signals death through JNK", "Rho GTPase cycle", "Regulation of actin dynamics for phagocytic cup formation", "Constitutive Signaling by Aberrant PI3K in Cancer", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "CD28 dependent Vav1 pathway", "G alpha (12/13) signalling events", "VEGFA-VEGFR2 Pathway", "VEGFA-VEGFR2 Pathway", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "VEGFR2 mediated vascular permeability", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Erythropoietin activates RAS", "Erythropoietin activates RAS", "Regulation of signaling by CBL", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P15502": ["Degradation of the extracellular matrix", "Elastic fibre formation", "Molecules associated with elastic fibres", "Molecules associated with elastic fibres"], "P15509": ["Interleukin-3, Interleukin-5 and GM-CSF signaling", "RAF/MAP kinase cascade", "Surfactant metabolism", "Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5)", "Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)", "Interleukin receptor SHC signaling"], "P15514": ["PIP3 activates AKT signaling", "Signaling by EGFR", "GRB2 events in EGFR signaling", "GAB1 signalosome", "SHC1 events in EGFR signaling", "EGFR downregulation", "COPII-mediated vesicle transport", "EGFR interacts with phospholipase C-gamma", "Constitutive Signaling by Aberrant PI3K in Cancer", "Inhibition of Signaling by Overexpressed EGFR", "RAF/MAP kinase cascade", "Cargo concentration in the ER", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "P15515": ["Antimicrobial peptides"], "P15516": ["Antimicrobial peptides"], "P15529": ["Regulation of Complement cascade"], "P15531": ["Interconversion of nucleotide di- and triphosphates"], "P15538": ["Glucocorticoid biosynthesis", "Endogenous sterols", "Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4)"], "P15559": ["Regulation of ornithine decarboxylase (ODC)"], "P15586": ["Keratan sulfate degradation", "MPS IIID - Sanfilippo syndrome D", "Lysosome Vesicle Biogenesis", "Neutrophil degranulation"], "P15622": ["Generic Transcription Pathway"], "P15692": ["Platelet degranulation ", "Regulation of gene expression by Hypoxia-inducible Factor", "VEGF ligand-receptor interactions", "VEGF binds to VEGFR leading to receptor dimerization", "Interleukin-4 and Interleukin-13 signaling", "TFAP2 (AP-2) family regulates transcription of growth factors and their receptors"], "P15692-4": ["VEGFA-VEGFR2 Pathway", "VEGFA-VEGFR2 Pathway", "VEGFR2 mediated cell proliferation"], "P15735": ["Glycogen breakdown (glycogenolysis)"], "P15813": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "P15814": ["Cell surface interactions at the vascular wall"], "P15848": ["Glycosphingolipid metabolism", "The activation of arylsulfatases", "CS/DS degradation", "MPS VI - Maroteaux-Lamy syndrome", "Neutrophil degranulation"], "P15880": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "RMTs methylate histone arginines", "rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Protein methylation", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P15882": ["Rho GTPase cycle"], "P15884": ["CDO in myogenesis", "CDO in myogenesis"], "P15907": ["Sialic acid metabolism", "N-Glycan antennae elongation", "Termination of O-glycan biosynthesis"], "P15917": ["Uptake and function of anthrax toxins"], "P15918": ["Interleukin-7 signaling", "MAPK6/MAPK4 signaling"], "P15923": ["CDO in myogenesis", "CDO in myogenesis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs"], "P15924": ["Apoptotic cleavage of cell adhesion proteins", "Neutrophil degranulation", "Keratinization", "Formation of the cornified envelope"], "P15927": ["Translesion synthesis by REV1", "Recognition of DNA damage by PCNA-containing replication complex", "Translesion Synthesis by POLH", "Removal of the Flap Intermediate from the C-strand", "Activation of ATR in response to replication stress", "Regulation of HSF1-mediated heat shock response", "HSF1 activation", "Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "PCNA-Dependent Long Patch Base Excision Repair", "Translesion synthesis by POLK", "Translesion synthesis by POLI", "Termination of translesion DNA synthesis", "HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Formation of Incision Complex in GG-NER", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Fanconi Anemia Pathway", "Regulation of TP53 Activity through Phosphorylation", "Activation of the pre-replicative complex", "Removal of the Flap Intermediate", "G2/M DNA damage checkpoint", "Meiotic recombination"], "P15941": ["Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)", "Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)", "Defective GALNT12 causes colorectal cancer 1 (CRCS1)", "Dectin-2 family", "Interleukin-4 and Interleukin-13 signaling", "O-linked glycosylation of mucins", "Termination of O-glycan biosynthesis"], "P15954": ["TP53 Regulates Metabolic Genes", "Respiratory electron transport"], "P15976": ["RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Factors involved in megakaryocyte development and platelet production"], "P16035": ["Activation of Matrix Metalloproteinases", "Neutrophil degranulation"], "P16050": ["Synthesis of Leukotrienes (LT) and Eoxins (EX)", "Synthesis of 12-eicosatetraenoic acid derivatives", "Synthesis of 15-eicosatetraenoic acid derivatives", "Interleukin-4 and Interleukin-13 signaling", "Biosynthesis of DHA-derived SPMs", "Biosynthesis of protectins", "Biosynthesis of E-series 18(S)-resolvins", "Biosynthesis of E-series 18(R)-resolvins", "Biosynthesis of DPAn-6 SPMs", "Biosynthesis of DPAn-3-derived protectins and resolvins"], "P16066": ["Physiological factors"], "P16070": ["Degradation of the extracellular matrix", "Cell surface interactions at the vascular wall", "Integrin cell surface interactions", "Hyaluronan uptake and degradation", "Neutrophil degranulation", "Interferon gamma signaling"], "P16083": ["Phase I - Functionalization of compounds"], "P16104": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "P16109": ["Platelet degranulation ", "Cell surface interactions at the vascular wall"], "P16112": ["Degradation of the extracellular matrix", "Degradation of the extracellular matrix", "Keratan sulfate biosynthesis", "Keratan sulfate degradation", "ECM proteoglycans", "Defective CHST6 causes MCDC1", "Defective ST3GAL3 causes MCT12 and EIEE15", "Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)"], "P16118": ["PKA-mediated phosphorylation of key metabolic factors", "PP2A-mediated dephosphorylation of key metabolic factors", "Glycolysis", "Glycolysis"], "P16144": ["Assembly of collagen fibrils and other multimeric structures", "Laminin interactions", "Syndecan interactions", "Type I hemidesmosome assembly"], "P16150": ["Cell surface interactions at the vascular wall", "Basigin interactions"], "P16152": ["Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"], "P16157": ["Interaction between L1 and Ankyrins", "Interaction between L1 and Ankyrins", "NrCAM interactions", "CHL1 interactions", "Neurofascin interactions", "Neurofascin interactions", "COPI-mediated anterograde transport"], "P16188": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P16189": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P16190": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P16219": ["Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "Beta oxidation of butanoyl-CoA to acetyl-CoA"], "P16220": ["PKA-mediated phosphorylation of CREB", "CaMK IV-mediated phosphorylation of CREB", "AKT phosphorylates targets in the nucleus", "CREB phosphorylation", "Transcriptional activation of mitochondrial biogenesis", "Transcriptional activation of mitochondrial biogenesis", "NOTCH2 intracellular domain regulates transcription", "NCAM signaling for neurite out-growth", "Circadian Clock", "Circadian Clock", "CREB1 phosphorylation through the activation of Adenylate Cyclase", "CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling", "Constitutive Signaling by AKT1 E17K in Cancer", "Gastrin-CREB signalling pathway via PKC and MAPK", "Regulation of MECP2 expression and activity", "MECP2 regulates neuronal receptors and channels", "MECP2 regulates transcription of neuronal ligands", "MECP2 regulates transcription factors"], "P16233": ["Digestion of dietary lipid", "Retinoid metabolism and transport"], "P16234": ["PIP3 activates AKT signaling", "Downstream signal transduction", "Signaling by PDGF", "Constitutive Signaling by Aberrant PI3K in Cancer", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "P16260": ["Coenzyme A biosynthesis"], "P16278": ["Glycosphingolipid metabolism", "Keratan sulfate degradation", "HS-GAG degradation", "MPS IV - Morquio syndrome B", "Sialic acid metabolism", "Neutrophil degranulation"], "P16284": ["Platelet degranulation ", "Cell surface interactions at the vascular wall", "PECAM1 interactions", "Integrin cell surface interactions", "Platelet sensitization by LDL", "Neutrophil degranulation"], "P16298": ["DARPP-32 events", "Calcineurin activates NFAT", "Calcineurin activates NFAT", "FCERI mediated Ca+2 mobilization", "Ca2+ pathway", "CLEC7A (Dectin-1) induces NFAT activation", "ROBO receptors bind AKAP5"], "P16333": ["Downstream signal transduction", "Generation of second messenger molecules", "Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "Nephrin family interactions", "DCC mediated attractive signaling", "DCC mediated attractive signaling", "Activation of RAC1", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P16383": ["mRNA Splicing - Major Pathway"], "P16389": ["Voltage gated Potassium channels"], "P16401": ["Activation of DNA fragmentation factor", "Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "P16402": ["Activation of DNA fragmentation factor", "Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "P16403": ["Activation of DNA fragmentation factor", "Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "P16410": ["CTLA4 inhibitory signaling", "RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)"], "P16422": ["Cell surface interactions at the vascular wall"], "P16435": ["Cytochrome P450 - arranged by substrate type"], "P16444": ["Synthesis of Leukotrienes (LT) and Eoxins (EX)", "Aflatoxin activation and detoxification"], "P16455": ["MGMT-mediated DNA damage reversal"], "P16471": ["Prolactin receptor signaling", "Prolactin receptor signaling", "Growth hormone receptor signaling"], "P16473": ["Hormone ligand-binding receptors", "G alpha (s) signalling events"], "P16499": ["Activation of the phototransduction cascade", "Activation of the phototransduction cascade", "Inactivation, recovery and regulation of the phototransduction cascade", "Ca2+ pathway", "Ca2+ pathway"], "P16519": ["Insulin processing"], "P16520": ["Activation of G protein gated Potassium channels", "Glucagon signaling in metabolic regulation", "G-protein activation", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42", "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "P16581": ["Cell surface interactions at the vascular wall"], "P16591": ["Signaling by SCF-KIT"], "P16615": ["Pre-NOTCH Processing in Golgi", "Reduction of cytosolic Ca++ levels", "Ion homeostasis", "Ion transport by P-type ATPases"], "P16619": ["Interleukin-10 signaling"], "P16662": ["Glucuronidation"], "P16671": ["Platelet degranulation ", "Cross-presentation of particulate exogenous antigens (phagosomes)", "ER-Phagosome pathway", "MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "Toll Like Receptor TLR6:TLR2 Cascade", "PPARA activates gene expression", "Scavenging by Class B Receptors", "Scavenging by Class B Receptors", "Transcriptional regulation of white adipocyte differentiation", "MyD88 deficiency (TLR2/4)", "IRAK4 deficiency (TLR2/4)", "Regulation of TLR by endogenous ligand", "Interleukin-4 and Interleukin-13 signaling", "Neutrophil degranulation"], "P16767": ["TNFR1-induced proapoptotic signaling", "Regulation of TNFR1 signaling"], "P16870": ["Insulin processing"], "P16871": ["Interleukin-7 signaling", "Interleukin-7 signaling", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "P16885": ["GPVI-mediated activation cascade", "Toll Like Receptor 4 (TLR4) Cascade", "Synthesis of IP3 and IP4 in the cytosol", "Role of phospholipids in phagocytosis", "DAP12 signaling", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "CLEC7A (Dectin-1) signaling", "CLEC7A (Dectin-1) signaling", "Dectin-2 family", "Dectin-2 family", "Erythropoietin activates Phospholipase C gamma (PLCG)", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P16930": ["Phenylalanine and tyrosine catabolism"], "P17014": ["Generic Transcription Pathway"], "P17017": ["Generic Transcription Pathway"], "P17019": ["Generic Transcription Pathway"], "P17021": ["Generic Transcription Pathway"], "P17022": ["Generic Transcription Pathway"], "P17023": ["Generic Transcription Pathway"], "P17024": ["Generic Transcription Pathway"], "P17027": ["Generic Transcription Pathway"], "P17029": ["Generic Transcription Pathway"], "P17030": ["Generic Transcription Pathway"], "P17031": ["Generic Transcription Pathway"], "P17032": ["Generic Transcription Pathway"], "P17035": ["Generic Transcription Pathway"], "P17036": ["Generic Transcription Pathway"], "P17038": ["Generic Transcription Pathway"], "P17039": ["Generic Transcription Pathway"], "P17066": ["Regulation of HSF1-mediated heat shock response", "Neutrophil degranulation"], "P17081": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Rho GTPase cycle", "RHO GTPases regulate CFTR trafficking"], "P17096": ["Integration of provirus", "2-LTR circle formation", "Integration of viral DNA into host genomic DNA", "Autointegration results in viral DNA circles", "APOBEC3G mediated resistance to HIV-1 infection", "Vpr-mediated nuclear import of PICs", "Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "P17152": ["Cristae formation"], "P17174": ["Methionine salvage pathway", "Gluconeogenesis", "Amino acid synthesis and interconversion (transamination)"], "P17181": ["Interferon alpha/beta signaling", "Regulation of IFNA signaling", "Regulation of IFNA signaling"], "P17213": ["Toll Like Receptor 4 (TLR4) Cascade", "Neutrophil degranulation", "Antimicrobial peptides"], "P17252": ["Calmodulin induced events", "Disinhibition of SNARE formation", "SHC1 events in ERBB2 signaling", "Signaling by SCF-KIT", "Regulation of KIT signaling", "EGFR Transactivation by Gastrin", "Inactivation, recovery and regulation of the phototransduction cascade", "Syndecan interactions", "Acetylcholine regulates insulin secretion", "Ca2+ pathway", "Trafficking of GluR2-containing AMPA receptors", "G alpha (z) signalling events", "Depolymerisation of the Nuclear Lamina", "HuR (ELAVL1) binds and stabilizes mRNA", "WNT5A-dependent internalization of FZD4", "VEGFR2 mediated cell proliferation", "RHO GTPases Activate NADPH Oxidases", "Response to elevated platelet cytosolic Ca2+", "RET signaling", "ROBO receptors bind AKAP5", "ROBO receptors bind AKAP5"], "P17275": ["SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Interleukin-4 and Interleukin-13 signaling"], "P17301": ["Integrin cell surface interactions", "Integrin cell surface interactions", "Laminin interactions", "Laminin interactions", "Syndecan interactions", "ECM proteoglycans", "CHL1 interactions", "Platelet Adhesion to exposed collagen", "MET activates PTK2 signaling"], "P17302": ["Oligomerization of connexins into connexons", "Transport of connexins along the secretory pathway", "Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "Gap junction assembly", "Gap junction assembly", "Gap junction degradation", "c-src mediated regulation of Cx43 function and closure of gap junctions", "c-src mediated regulation of Cx43 function and closure of gap junctions", "Formation of annular gap junctions"], "P17405": ["Glycosphingolipid metabolism"], "P17480": ["NoRC negatively regulates rRNA expression", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase I Transcription Termination"], "P17483": ["Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "P17516": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of bile acids and bile salts via 24-hydroxycholesterol", "Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "Retinoid metabolism and transport"], "P17535": ["Estrogen-dependent gene expression"], "P17538": ["Activation of Matrix Metalloproteinases", "Cobalamin (Cbl, vitamin B12) transport and metabolism"], "P17540": ["Creatine metabolism"], "P17542": ["RUNX1 regulates transcription of genes involved in differentiation of HSCs"], "P17568": ["Respiratory electron transport", "Complex I biogenesis"], "P17600": ["Serotonin Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle"], "P17612": ["PKA-mediated phosphorylation of CREB", "PKA-mediated phosphorylation of key metabolic factors", "Triglyceride catabolism", "PKA activation", "PKA activation in glucagon signalling", "DARPP-32 events", "Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Rap1 signalling", "Regulation of insulin secretion", "Vasopressin regulates renal water homeostasis via Aquaporins", "VEGFA-VEGFR2 Pathway", "CREB1 phosphorylation through the activation of Adenylate Cyclase", "CREB1 phosphorylation through the activation of Adenylate Cyclase", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "Ion homeostasis", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'off' state", "Anchoring of the basal body to the plasma membrane", "CD209 (DC-SIGN) signaling", "MAPK6/MAPK4 signaling", "Glycolysis", "RET signaling", "AURKA Activation by TPX2", "HDL assembly", "ROBO receptors bind AKAP5", "Loss of phosphorylation of MECP2 at T308", "Regulation of MECP2 expression and activity", "Factors involved in megakaryocyte development and platelet production"], "P17643": ["Melanin biosynthesis"], "P17655": ["Degradation of the extracellular matrix", "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models"], "P17658": ["Voltage gated Potassium channels"], "P17661": ["Striated Muscle Contraction"], "P17676": ["Senescence-Associated Secretory Phenotype (SASP)", "Senescence-Associated Secretory Phenotype (SASP)", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "P17677": ["L1CAM interactions"], "P17693": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P17706": ["Negative regulation of MET activity", "Interleukin-37 signaling"], "P17706-2": ["Regulation of IFNG signaling"], "P17707": ["Metabolism of polyamines"], "P17735": ["Phenylalanine and tyrosine catabolism"], "P17752": ["Serotonin and melatonin biosynthesis"], "P17787": ["Highly sodium permeable acetylcholine nicotinic receptors", "Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "Highly calcium permeable nicotinic acetylcholine receptors"], "P17812": ["Interconversion of nucleotide di- and triphosphates"], "P17844": ["SUMOylation of transcription cofactors", "mRNA Splicing - Major Pathway", "Estrogen-dependent gene expression"], "P17858": ["Neutrophil degranulation", "Glycolysis"], "P17861-2": ["XBP1(S) activates chaperone genes", "IRE1alpha activates chaperones", "ATF6 (ATF6-alpha) activates chaperone genes"], "P17900": ["Glycosphingolipid metabolism", "Neutrophil degranulation"], "P17927": ["Neutrophil degranulation", "RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "Regulation of Complement cascade"], "P17931": ["Neutrophil degranulation", "Advanced glycosylation endproduct receptor signaling", "RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "RUNX2 regulates genes involved in differentiation of myeloid cells"], "P17936": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "TP53 Regulates Transcription of Death Receptors and Ligands", "Post-translational protein phosphorylation"], "P17947": ["RUNX1 regulates transcription of genes involved in differentiation of HSCs"], "P17948": ["Neurophilin interactions with VEGF and VEGFR", "VEGF binds to VEGFR leading to receptor dimerization"], "P17980": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "Neutrophil degranulation", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "P17987": ["Prefoldin mediated transfer of substrate to CCT/TriC", "Formation of tubulin folding intermediates by CCT/TriC", "Folding of actin by CCT/TriC", "Association of TriC/CCT with target proteins during biosynthesis", "Association of TriC/CCT with target proteins during biosynthesis", "BBSome-mediated cargo-targeting to cilium", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "P18031": ["Integrin alphaIIb beta3 signaling", "Negative regulation of MET activity", "Regulation of IFNG signaling", "PTK6 Down-Regulation", "MECP2 regulates neuronal receptors and channels", "Regulation of IFNA signaling", "Growth hormone receptor signaling", "Growth hormone receptor signaling"], "P18054": ["Synthesis of Hepoxilins (HX) and Trioxilins (TrX)", "Synthesis of Lipoxins (LX)", "Synthesis of 12-eicosatetraenoic acid derivatives", "Biosynthesis of DHA-derived SPMs", "Biosynthesis of DPAn-6 SPMs", "Biosynthesis of DPAn-3-derived maresins"], "P18065": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "P18074": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Tat-mediated elongation of the HIV-1 transcript", "Cytosolic iron-sulfur cluster assembly", "NoRC negatively regulates rRNA expression", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "mRNA Capping", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase I Transcription Termination", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE"], "P18075": ["Molecules associated with elastic fibres"], "P18077": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P18084": ["Cross-presentation of particulate exogenous antigens (phagosomes)", "Molecules associated with elastic fibres", "Integrin cell surface interactions", "Integrin cell surface interactions", "Syndecan interactions", "Syndecan interactions", "ECM proteoglycans", "Smooth Muscle Contraction"], "P18085": ["VxPx cargo-targeting to cilium", "VxPx cargo-targeting to cilium", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "P18089": ["Adrenoceptors", "Adrenaline signalling through Alpha-2 adrenergic receptor", "G alpha (i) signalling events", "G alpha (z) signalling events"], "P18124": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P18146": ["Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription", "Interferon alpha/beta signaling"], "P18195": ["Scavenging by Class F Receptors", "Scavenging by Class F Receptors"], "P18206": ["Platelet degranulation ", "Smooth Muscle Contraction", "MAP2K and MAPK activation", "Neutrophil degranulation", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF"], "P18283": ["Synthesis of 5-eicosatetraenoic acids", "Synthesis of 12-eicosatetraenoic acid derivatives", "Synthesis of 15-eicosatetraenoic acid derivatives", "Detoxification of Reactive Oxygen Species", "TP53 Regulates Metabolic Genes"], "P18405": ["Androgen biosynthesis"], "P18428": ["Toll Like Receptor 4 (TLR4) Cascade", "Transfer of LPS from LBP carrier to CD14", "Regulation of TLR by endogenous ligand", "Interleukin-4 and Interleukin-13 signaling"], "P18433": ["NCAM signaling for neurite out-growth", "NCAM signaling for neurite out-growth", "RAF/MAP kinase cascade"], "P18440": ["Acetylation"], "P18462": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P18463": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P18464": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P18465": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P18505": ["GABA A receptor activation", "GABA receptor activation"], "P18507": ["GABA A receptor activation", "GABA receptor activation"], "P18509": ["NGF-independant TRKA activation", "G alpha (s) signalling events", "Glucagon-type ligand receptors"], "P18510": ["Interleukin-10 signaling", "Interleukin-1 signaling"], "P18545": ["Activation of the phototransduction cascade", "Activation of the phototransduction cascade", "Inactivation, recovery and regulation of the phototransduction cascade", "Ca2+ pathway", "Ca2+ pathway"], "P18564": ["Elastic fibre formation", "Molecules associated with elastic fibres", "Integrin cell surface interactions", "ECM proteoglycans"], "P18615": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Abortive elongation of HIV-1 transcript in the absence of Tat", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "RNA Polymerase II Transcription Elongation"], "P18621": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P18627": ["MHC class II antigen presentation"], "P18640": ["Toxicity of botulinum toxin type C (BoNT/C)"], "P18669": ["Neutrophil degranulation", "Glycolysis", "Gluconeogenesis"], "P18754": ["Rev-mediated nuclear export of HIV RNA", "Nuclear import of Rev protein"], "P18799": ["Dectin-2 family"], "P18825": ["Adrenoceptors", "Adrenaline signalling through Alpha-2 adrenergic receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "G alpha (i) signalling events", "G alpha (z) signalling events", "Surfactant metabolism"], "P18827": ["A tetrasaccharide linker sequence is required for GAG synthesis", "HS-GAG biosynthesis", "HS-GAG biosynthesis", "HS-GAG degradation", "Cell surface interactions at the vascular wall", "Syndecan interactions", "Syndecan interactions", "Defective B4GALT7 causes EDS, progeroid type", "Defective B3GAT3 causes JDSSDHD", "Defective EXT2 causes exostoses 2", "Defective EXT1 causes exostoses 1, TRPS2 and CHDS", "Defective B3GALT6 causes EDSP2 and SEMDJL1", "Other interleukin signaling", "Retinoid metabolism and transport"], "P18846": ["CREB phosphorylation"], "P18847": ["ATF4 activates genes"], "P18848": ["ATF4 activates genes", "PERK regulates gene expression", "ATF6 (ATF6-alpha) activates chaperone genes"], "P18850": ["ATF4 activates genes", "ATF6 (ATF6-alpha) activates chaperones", "ATF6 (ATF6-alpha) activates chaperone genes"], "P18858": ["POLB-Dependent Long Patch Base Excision Repair", "Early Phase of HIV Life Cycle", "Processive synthesis on the C-strand of the telomere", "Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "PCNA-Dependent Long Patch Base Excision Repair", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Processive synthesis on the lagging strand"], "P18859": ["Formation of ATP by chemiosmotic coupling", "Cristae formation"], "P18887": ["Resolution of AP sites via the single-nucleotide replacement pathway", "APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "HDR through MMEJ (alt-NHEJ)", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER"], "P19012": ["Keratinization", "Formation of the cornified envelope"], "P19013": ["Keratinization", "Formation of the cornified envelope"], "P19022": ["CDO in myogenesis", "CDO in myogenesis", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Adherens junctions interactions", "Post-translational protein phosphorylation"], "P19086": ["PLC beta mediated events", "PLC beta mediated events", "G-protein activation", "G alpha (s) signalling events", "G alpha (i) signalling events", "G alpha (z) signalling events", "G alpha (z) signalling events", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "P19087": ["PLC beta mediated events", "PLC beta mediated events", "G-protein activation", "Ca2+ pathway", "Ca2+ pathway", "G alpha (i) signalling events", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "P19099": ["Mineralocorticoid biosynthesis", "Glucocorticoid biosynthesis", "Endogenous sterols", "Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)"], "P19105": ["Ephrin signaling", "Smooth Muscle Contraction"], "P19113": ["Histidine catabolism"], "P19174": ["ISG15 antiviral mechanism", "Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "PLCG1 events in ERBB2 signaling", "DAG and IP3 signaling", "PLC-gamma1 signalling", "Synthesis of IP3 and IP4 in the cytosol", "Downstream signal transduction", "Generation of second messenger molecules", "Role of phospholipids in phagocytosis", "Role of phospholipids in phagocytosis", "PECAM1 interactions", "EGFR interacts with phospholipase C-gamma", "DAP12 signaling", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "Role of second messengers in netrin-1 signaling", "VEGFR2 mediated cell proliferation", "VEGFR2 mediated cell proliferation", "Constitutive Signaling by EGFRvIII", "Phospholipase C-mediated cascade: FGFR1", "Phospholipase C-mediated cascade; FGFR2", "Phospholipase C-mediated cascade; FGFR3", "Phospholipase C-mediated cascade; FGFR4", "Signaling by FGFR2 in disease", "Signaling by FGFR4 in disease", "Signaling by FGFR1 in disease", "Signaling by FGFR3 point mutants in cancer", "RET signaling", "Activated NTRK2 signals through PLCG1", "Activated NTRK2 signals through PLCG1", "Erythropoietin activates Phospholipase C gamma (PLCG)", "Activated NTRK3 signals through PLCG1", "Activated NTRK3 signals through PLCG1"], "P19214": ["Cell surface interactions at the vascular wall"], "P19224": ["Glucuronidation"], "P19235": ["Signaling by Erythropoietin", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "Erythropoietin activates Phospholipase C gamma (PLCG)", "Erythropoietin activates STAT5", "Erythropoietin activates RAS", "Erythropoietin activates RAS"], "P19237": ["Striated Muscle Contraction"], "P19256": ["Cell surface interactions at the vascular wall", "Neutrophil degranulation"], "P19320": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Integrin cell surface interactions", "Interleukin-4 and Interleukin-13 signaling", "Interferon gamma signaling"], "P19321": ["Toxicity of botulinum toxin type D (BoNT/D)"], "P19338": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "P19367": ["Defective HK1 causes hexokinase deficiency (HK deficiency)", "Glycolysis"], "P19387": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Abortive elongation of HIV-1 transcript in the absence of Tat", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "Viral Messenger RNA Synthesis", "MicroRNA (miRNA) biogenesis", "Transcriptional regulation of pluripotent stem cells", "Transcriptional regulation by small RNAs", "PIWI-interacting RNA (piRNA) biogenesis", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE", "Signaling by FGFR2 IIIa TM", "Estrogen-dependent gene expression"], "P19388": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Abortive elongation of HIV-1 transcript in the absence of Tat", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "Viral Messenger RNA Synthesis", "Cytosolic sensors of pathogen-associated DNA ", "MicroRNA (miRNA) biogenesis", "NoRC negatively regulates rRNA expression", "Transcriptional regulation of pluripotent stem cells", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "PIWI-interacting RNA (piRNA) biogenesis", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase III Chain Elongation", "RNA Polymerase I Transcription Termination", "RNA Polymerase III Transcription Termination", "RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Pol II CTD phosphorylation and interaction with CE", "Signaling by FGFR2 IIIa TM", "Estrogen-dependent gene expression"], "P19397": ["Neutrophil degranulation"], "P19404": ["Respiratory electron transport", "Complex I biogenesis"], "P19419": ["ERK/MAPK targets"], "P19429": ["Striated Muscle Contraction", "Ion homeostasis"], "P19438": ["TNFR1-induced proapoptotic signaling", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "TNFR1-mediated ceramide production", "TNFs bind their physiological receptors", "Interleukin-10 signaling", "TNF signaling"], "P19440": ["Glutathione synthesis and recycling", "Synthesis of Leukotrienes (LT) and Eoxins (EX)", "Aflatoxin activation and detoxification", "Defective GGT1 causes Glutathionuria (GLUTH)", "Defective GGT1 causes Glutathionuria (GLUTH)"], "P19447": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Tat-mediated elongation of the HIV-1 transcript", "NoRC negatively regulates rRNA expression", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "mRNA Capping", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase I Transcription Termination", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE"], "P19474": ["STING mediated induction of host immune responses", "Regulation of innate immune responses to cytosolic DNA", "Interferon gamma signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "P19525": ["ISG15 antiviral mechanism", "Inhibition of PKR"], "P19549": ["Dectin-2 family"], "P19550": ["Dectin-2 family"], "P19551": ["Dectin-2 family"], "P19623": ["Metabolism of polyamines"], "P19634": ["Hyaluronan uptake and degradation", "Sodium/Proton exchangers"], "P19652": ["Platelet degranulation ", "Neutrophil degranulation"], "P19784": ["Synthesis of PC", "WNT mediated activation of DVL", "Condensation of Prometaphase Chromosomes", "Signal transduction by L1", "Regulation of TP53 Activity through Phosphorylation", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "Receptor Mediated Mitophagy", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Regulation of PTEN stability and activity"], "P19793": ["RORA activates gene expression", "BMAL1:CLOCK,NPAS2 activates circadian gene expression", "Recycling of bile acids and salts", "Synthesis of bile acids and bile salts", "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "PPARA activates gene expression", "PPARA activates gene expression", "Import of palmitoyl-CoA into the mitochondrial matrix", "Regulation of pyruvate dehydrogenase (PDH) complex", "Endogenous sterols", "Transcriptional activation of mitochondrial biogenesis", "Activation of gene expression by SREBF (SREBP)", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation", "Nuclear Receptor transcription pathway", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)", "Circadian Clock", "SUMOylation of intracellular receptors", "Signaling by Retinoic Acid", "Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "P19801": ["Phase I - Functionalization of compounds", "Neutrophil degranulation"], "P19823": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "P19835": ["Digestion of dietary lipid"], "P19838": ["Activation of NF-kappaB in B cells", "RIP-mediated NFkB activation via ZBP1", "Regulated proteolysis of p75NTR", "Downstream TCR signaling", "NF-kB is activated and signals survival", "Senescence-Associated Secretory Phenotype (SASP)", "FCERI mediated NF-kB activation", "DEx/H-box helicases activate type I IFN and inflammatory cytokines production ", "PKMTs methylate histone lysines", "Transcriptional regulation of white adipocyte differentiation", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "Interleukin-1 processing", "IkBA variant leads to EDA-ID", "CLEC7A (Dectin-1) signaling", "CD209 (DC-SIGN) signaling", "CLEC7A/inflammasome pathway", "MAP3K8 (TPL2)-dependent MAPK1/3 activation", "Neutrophil degranulation", "The NLRP3 inflammasome", "Interleukin-1 signaling", "TRAF6 mediated NF-kB activation"], "P19875": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events", "Interleukin-10 signaling"], "P19876": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "P19878": ["ROS, RNS production in phagocytes", "Cross-presentation of particulate exogenous antigens (phagosomes)", "Detoxification of Reactive Oxygen Species", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate NADPH Oxidases"], "P19883": ["Antagonism of Activin by Follistatin"], "P19957": ["Antimicrobial peptides", "Formation of the cornified envelope"], "P19961": ["Digestion of dietary carbohydrate"], "P19971": ["Pyrimidine salvage", "Pyrimidine catabolism"], "P20020": ["Reduction of cytosolic Ca++ levels", "Ion homeostasis", "Ion transport by P-type ATPases"], "P20023": ["Regulation of Complement cascade"], "P20036": ["Downstream TCR signaling", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "MHC class II antigen presentation", "PD-1 signaling", "Interferon gamma signaling"], "P20039": ["Downstream TCR signaling", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "MHC class II antigen presentation", "PD-1 signaling", "Interferon gamma signaling"], "P20042": ["L13a-mediated translational silencing of Ceruloplasmin expression", "ABC-family proteins mediated transport", "Translation initiation complex formation", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Recycling of eIF2:GDP"], "P20061": ["Cobalamin (Cbl, vitamin B12) transport and metabolism", "Neutrophil degranulation"], "P20062": ["Cobalamin (Cbl, vitamin B12) transport and metabolism", "Defective TCN2 causes hereditary megaloblastic anemia", "Defective CD320 causes methylmalonic aciduria"], "P20132": ["Threonine catabolism"], "P20138": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation"], "P20151": ["Activation of Matrix Metalloproteinases", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3"], "P20160": ["Neutrophil degranulation"], "P20226": ["HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase I Transcription Termination", "RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "Estrogen-dependent gene expression"], "P20248": ["Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1", "G0 and Early G1", "Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Regulation of APC/C activators between G1/S and early anaphase", "SCF(Skp2)-mediated degradation of p27/p21", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "Ub-specific processing proteases", "Processing of DNA double-strand break ends", "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "Regulation of TP53 Activity through Phosphorylation", "Regulation of TP53 Degradation", "G2 Phase", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Cyclin A/B1/B2 associated events during G2/M transition", "Cyclin A/B1/B2 associated events during G2/M transition", "p53-Dependent G1 DNA Damage Response", "Cyclin A:Cdk2-associated events at S phase entry"], "P20273": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "CD22 mediated BCR regulation", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P20292": ["Synthesis of 5-eicosatetraenoic acids", "Synthesis of Leukotrienes (LT) and Eoxins (EX)", "Synthesis of Lipoxins (LX)"], "P20309": ["Muscarinic acetylcholine receptors", "Acetylcholine regulates insulin secretion", "G alpha (q) signalling events"], "P20333": ["TNFR2 non-canonical NF-kB pathway", "TNFs bind their physiological receptors", "Interleukin-10 signaling", "Interleukin-4 and Interleukin-13 signaling", "Neutrophil degranulation"], "P20336": ["Serotonin Neurotransmitter Release Cycle", "Norepinephrine Neurotransmitter Release Cycle", "Glutamate Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle", "Acetylcholine Neurotransmitter Release Cycle", "Neutrophil degranulation", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs", "GABA synthesis, release, reuptake and degradation"], "P20337": ["RAB geranylgeranylation"], "P20338": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Synthesis of PIPs at the plasma membrane", "TBC/RABGAPs", "RAB geranylgeranylation", "MET receptor recycling"], "P20339": ["Synthesis of PIPs at the plasma membrane", "TBC/RABGAPs", "Clathrin-mediated endocytosis", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs", "Factors involved in megakaryocyte development and platelet production"], "P20340": ["Pre-NOTCH Processing in Golgi", "Neutrophil degranulation", "COPI-independent Golgi-to-ER retrograde traffic", "Retrograde transport at the Trans-Golgi-Network", "TBC/RABGAPs", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "P20366": ["Tachykinin receptors bind tachykinins", "G alpha (q) signalling events"], "P20382": ["Peptide ligand-binding receptors", "G alpha (q) signalling events", "G alpha (i) signalling events"], "P20393": ["NR1D1 (REV-ERBA) represses gene expression", "PPARA activates gene expression", "Transcriptional activation of mitochondrial biogenesis", "Nuclear Receptor transcription pathway", "Circadian Clock", "Circadian Clock"], "P20396": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "P20472": ["Transcriptional Regulation by MECP2"], "P20585": ["Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "Defective Mismatch Repair Associated With MSH3", "Defective Mismatch Repair Associated With MSH2"], "P20591": ["ISG15 antiviral mechanism", "Interferon alpha/beta signaling"], "P20592": ["ISG15 antiviral mechanism", "Interferon alpha/beta signaling"], "P20594": ["Physiological factors"], "P20618": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "Neutrophil degranulation", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "P20645": ["Lysosome Vesicle Biogenesis", "Retrograde transport at the Trans-Golgi-Network", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "P20648": ["Ion transport by P-type ATPases"], "P20671": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "HATs acetylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "UCH proteinases", "Ub-specific processing proteases", "Metalloprotease DUBs", "Deposition of new CENPA-containing nucleosomes at the centromere", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "P20674": ["TP53 Regulates Metabolic Genes", "Respiratory electron transport"], "P20700": ["Meiotic synapsis", "Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "Clearance of Nuclear Envelope Membranes from Chromatin", "Initiation of Nuclear Envelope Reformation", "Breakdown of the nuclear lamina", "Depolymerisation of the Nuclear Lamina", "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "P20701": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "Integrin cell surface interactions", "Neutrophil degranulation", "RUNX3 Regulates Immune Response and Cell Migration"], "P20702": ["Cell surface interactions at the vascular wall", "Integrin cell surface interactions", "ECM proteoglycans", "Interleukin-4 and Interleukin-13 signaling", "Neutrophil degranulation"], "P20711": ["Catecholamine biosynthesis", "Serotonin and melatonin biosynthesis"], "P20718": ["Metabolism of Angiotensinogen to Angiotensins", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "P20774": ["Keratan sulfate biosynthesis", "Keratan sulfate degradation", "Defective CHST6 causes MCDC1", "Defective ST3GAL3 causes MCT12 and EIEE15", "Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)"], "P20783": ["NTF3 activates NTRK2 (TRKB) signaling", "NTF3 activates NTRK3 signaling", "NTF3 activates NTRK3 signaling", "Signaling by NTRK3 (TRKC)", "Activated NTRK3 signals through PLCG1", "Activated NTRK3 signals through PLCG1", "Activated NTRK3 signals through RAS", "Activated NTRK3 signals through PI3K", "Activated NTRK3 signals through PI3K"], "P20800": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "P20807": ["Degradation of the extracellular matrix"], "P20809": ["IL-6-type cytokine receptor ligand interactions"], "P20810": ["Degradation of the extracellular matrix", "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models"], "P20813": ["Fatty acids", "Xenobiotics", "CYP2E1 reactions"], "P20815": ["Xenobiotics", "Aflatoxin activation and detoxification"], "P20823": ["Regulation of gene expression in beta cells"], "P20827": ["EPH-Ephrin signaling", "EPH-Ephrin signaling", "EPHA-mediated growth cone collapse", "EPHA-mediated growth cone collapse", "EPH-ephrin mediated repulsion of cells", "EPH-ephrin mediated repulsion of cells"], "P20839": ["Neutrophil degranulation", "Purine ribonucleoside monophosphate biosynthesis"], "P20849": ["Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Signaling by PDGF", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "ECM proteoglycans", "NCAM1 interactions", "Collagen chain trimerization"], "P20851": ["Regulation of Complement cascade"], "P20853": ["Fatty acids", "Xenobiotics", "CYP2E1 reactions"], "P20871": ["Dectin-2 family"], "P20888": ["Dectin-2 family"], "P20908": ["Collagen degradation", "Extracellular matrix organization", "Collagen biosynthesis and modifying enzymes", "Signaling by PDGF", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "Syndecan interactions", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "NCAM1 interactions", "MET activates PTK2 signaling", "Collagen chain trimerization"], "P20916": ["Axonal growth inhibition (RHOA activation)", "Basigin interactions"], "P20929": ["Striated Muscle Contraction"], "P20930": ["Formation of the cornified envelope"], "P20933": ["Neutrophil degranulation"], "P20936": ["Downstream signal transduction", "EPHB-mediated forward signaling", "EPHB-mediated forward signaling", "VEGFR2 mediated cell proliferation", "Regulation of RAS by GAPs", "Signaling by RAS mutants", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases"], "P20963-1": ["Nef and signal transduction", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Downstream TCR signaling", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "PD-1 signaling"], "P21108": ["5-Phosphoribose 1-diphosphate biosynthesis"], "P21127": ["Recruitment of mitotic centrosome proteins and complexes"], "P21217": ["Reactions specific to the complex N-glycan synthesis pathway"], "P21266": ["Glutathione conjugation"], "P21281": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "P21283": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "P21291": ["MTF1 activates gene expression"], "P21333": ["Platelet degranulation ", "GP1b-IX-V activation signalling", "Cell-extracellular matrix interactions", "RHO GTPases activate PAKs", "OAS antiviral response"], "P21359": ["Regulation of RAS by GAPs", "Signaling by RAS mutants", "RAS signaling downstream of NF1 loss-of-function variants"], "P21397": ["Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB", "Norepinephrine Neurotransmitter Release Cycle", "Enzymatic degradation of dopamine by COMT", "Enzymatic degradation of Dopamine by monoamine oxidase", "Metabolism of serotonin", "Defective MAOA causes Brunner syndrome (BRUNS)", "Interleukin-4 and Interleukin-13 signaling"], "P21399": ["Iron uptake and transport"], "P21439": ["PPARA activates gene expression", "ABC-family proteins mediated transport", "Defective ABCB4 causes progressive familial intrahepatic cholestasis 3, intrahepatic cholestasis of pregnancy 3 and gallbladder disease 1"], "P21452": ["Tachykinin receptors bind tachykinins", "G alpha (q) signalling events"], "P21453": ["G alpha (i) signalling events", "Lysosphingolipid and LPA receptors", "Interleukin-4 and Interleukin-13 signaling"], "P21462": ["G alpha (i) signalling events", "Formyl peptide receptors bind formyl peptides and many other ligands", "Interleukin-10 signaling", "Neutrophil degranulation"], "P21506": ["Generic Transcription Pathway"], "P21549": ["Glyoxylate metabolism and glycine degradation", "Peroxisomal protein import", "Peroxisomal protein import"], "P21554": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (i) signalling events"], "P21579": ["Serotonin Neurotransmitter Release Cycle", "Norepinephrine Neurotransmitter Release Cycle", "Glutamate Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle", "Acetylcholine Neurotransmitter Release Cycle", "Toxicity of botulinum toxin type B (BoNT/B)", "Toxicity of botulinum toxin type G (BoNT/G)", "Neurexins and neuroligins", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "GABA synthesis, release, reuptake and degradation"], "P21580": ["NOD1/2 Signaling Pathway", "TNFR1-induced proapoptotic signaling", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "Ovarian tumor domain proteases", "Negative regulators of DDX58/IFIH1 signaling"], "P21583-1": ["PIP3 activates AKT signaling", "Signaling by SCF-KIT", "Signaling by SCF-KIT", "Regulation of KIT signaling", "Regulation of KIT signaling", "Constitutive Signaling by Aberrant PI3K in Cancer", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "P21589": ["Nicotinate metabolism", "Pyrimidine catabolism", "Purine catabolism"], "P21673": ["Interconversion of polyamines"], "P21675": ["HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "P21695": ["Synthesis of PA"], "P21709": ["EPH-Ephrin signaling", "EPH-Ephrin signaling", "POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation", "EPHA-mediated growth cone collapse", "EPHA-mediated growth cone collapse", "EPH-ephrin mediated repulsion of cells", "EPH-ephrin mediated repulsion of cells"], "P21728": ["Dopamine receptors", "G alpha (s) signalling events"], "P21730": ["Peptide ligand-binding receptors", "G alpha (i) signalling events", "Neutrophil degranulation", "Regulation of Complement cascade"], "P21731": ["Prostanoid ligand receptors", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "Thromboxane signalling through TP receptor"], "P21741": ["NOTCH2 Activation and Transmission of Signal to the Nucleus"], "P21754": ["Interaction With The Zona Pellucida"], "P21757": ["Scavenging by Class A Receptors", "Scavenging by Class A Receptors"], "P21781": ["PI3K Cascade", "PIP3 activates AKT signaling", "FGFR2b ligand binding and activation", "Activated point mutants of FGFR2", "Constitutive Signaling by Aberrant PI3K in Cancer", "Phospholipase C-mediated cascade; FGFR2", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "Negative regulation of FGFR2 signaling", "Signaling by FGFR2 in disease", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "P21796": ["Mitochondrial protein import", "Pink/Parkin Mediated Mitophagy", "Ub-specific processing proteases", "Pyruvate metabolism", "Mitochondrial calcium ion transport"], "P21802": ["Signaling by FGFR2 amplification mutants", "Activated point mutants of FGFR2", "Signaling by FGFR2 in disease", "Signaling by FGFR2 IIIa TM", "Signaling by FGFR2 fusions"], "P21802-1": ["PI3K Cascade", "PIP3 activates AKT signaling", "FGFR2c ligand binding and activation", "Activated point mutants of FGFR2", "Constitutive Signaling by Aberrant PI3K in Cancer", "Phospholipase C-mediated cascade; FGFR2", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "Negative regulation of FGFR2 signaling", "Signaling by FGFR2 in disease", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Signaling by FGFR2 IIIa TM"], "P21802-17": ["Signaling by FGFR2 amplification mutants", "Signaling by FGFR2 in disease"], "P21802-18": ["PI3K Cascade", "PIP3 activates AKT signaling", "FGFR2b ligand binding and activation", "Constitutive Signaling by Aberrant PI3K in Cancer", "Phospholipase C-mediated cascade; FGFR2", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "Negative regulation of FGFR2 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Signaling by FGFR2 IIIa TM"], "P21802-3": ["PI3K Cascade", "PIP3 activates AKT signaling", "FGFR2b ligand binding and activation", "Activated point mutants of FGFR2", "Constitutive Signaling by Aberrant PI3K in Cancer", "Phospholipase C-mediated cascade; FGFR2", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "Negative regulation of FGFR2 signaling", "Signaling by FGFR2 in disease", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Signaling by FGFR2 IIIa TM"], "P21802-5": ["PI3K Cascade", "PIP3 activates AKT signaling", "FGFR2c ligand binding and activation", "Constitutive Signaling by Aberrant PI3K in Cancer", "Phospholipase C-mediated cascade; FGFR2", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "Negative regulation of FGFR2 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Signaling by FGFR2 IIIa TM"], "P21810": ["A tetrasaccharide linker sequence is required for GAG synthesis", "Chondroitin sulfate biosynthesis", "Dermatan sulfate biosynthesis", "CS/DS degradation", "ECM proteoglycans", "ECM proteoglycans", "Defective B4GALT7 causes EDS, progeroid type", "Defective B3GAT3 causes JDSSDHD", "Defective CHST3 causes SEDCJD", "Defective CHST14 causes EDS, musculocontractural type", "Defective CHSY1 causes TPBS", "Defective B3GALT6 causes EDSP2 and SEMDJL1"], "P21815": ["Integrin cell surface interactions", "ECM proteoglycans"], "P21817": ["Stimuli-sensing channels", "Ion homeostasis"], "P21854": ["Other semaphorin interactions"], "P21860-1": ["Signaling by ERBB2", "Signaling by ERBB4", "SHC1 events in ERBB2 signaling", "SHC1 events in ERBB2 signaling", "PIP3 activates AKT signaling", "GRB7 events in ERBB2 signaling", "Downregulation of ERBB2:ERBB3 signaling", "PI3K events in ERBB2 signaling", "Constitutive Signaling by Aberrant PI3K in Cancer", "RAF/MAP kinase cascade", "ERBB2 Regulates Cell Motility", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "ERBB2 Activates PTK6 Signaling", "Downregulation of ERBB2 signaling"], "P21912": ["Respiratory electron transport", "Citric acid cycle (TCA cycle)"], "P21917": ["Dopamine receptors", "G alpha (i) signalling events"], "P21918": ["Dopamine receptors", "G alpha (s) signalling events"], "P21926": ["Platelet degranulation ", "Sperm:Oocyte Membrane Binding", "Uptake and function of diphtheria toxin"], "P21941": ["ECM proteoglycans"], "P21953": ["Glyoxylate metabolism and glycine degradation", "Branched-chain amino acid catabolism"], "P21964": ["Methylation", "Enzymatic degradation of dopamine by COMT", "Enzymatic degradation of Dopamine by monoamine oxidase"], "P22001": ["Voltage gated Potassium channels"], "P22033": ["Cobalamin (Cbl, vitamin B12) transport and metabolism", "Defective MMAA causes methylmalonic aciduria type cblA", "Defective MUT causes methylmalonic aciduria mut type", "Propionyl-CoA catabolism"], "P22059": ["Sphingolipid de novo biosynthesis", "Synthesis of bile acids and bile salts"], "P22061": ["Protein repair"], "P22079": ["Events associated with phagocytolytic activity of PMN cells"], "P22087": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "P22090": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P22102": ["Purine ribonucleoside monophosphate biosynthesis"], "P22105": ["ECM proteoglycans"], "P22223": ["Adherens junctions interactions"], "P22234": ["Purine ribonucleoside monophosphate biosynthesis"], "P22301": ["Interleukin-10 signaling", "Interleukin-4 and Interleukin-13 signaling", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "P22303": ["Neurotransmitter clearance", "Synthesis of PC", "Synthesis, secretion, and deacylation of Ghrelin"], "P22304": ["HS-GAG degradation", "CS/DS degradation", "MPS II - Hunter syndrome"], "P22307": ["alpha-linolenic acid (ALA) metabolism", "Peroxisomal protein import", "Peroxisomal protein import", "TYSND1 cleaves peroxisomal proteins"], "P22307-1": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Beta-oxidation of pristanoyl-CoA"], "P22309": ["Glucuronidation", "Heme degradation", "Defective UGT1A1 causes hyperbilirubinemia"], "P22310": ["Glucuronidation", "Heme degradation", "Defective UGT1A4 causes hyperbilirubinemia"], "P22314": ["Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Antigen processing: Ubiquitination & Proteasome degradation"], "P22352": ["Detoxification of Reactive Oxygen Species"], "P22362": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "P22392": ["Interconversion of nucleotide di- and triphosphates", "Neutrophil degranulation"], "P22413": ["Vitamin B2 (riboflavin) metabolism", "Vitamin B5 (pantothenate) metabolism"], "P22415": ["Estrogen-dependent gene expression"], "P22455": ["PI3K Cascade", "PIP3 activates AKT signaling", "betaKlotho-mediated ligand binding", "FGFR4 mutant receptor activation", "FGFR4 ligand binding and activation", "Constitutive Signaling by Aberrant PI3K in Cancer", "Phospholipase C-mediated cascade; FGFR4", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "PI-3K cascade:FGFR4", "Negative regulation of FGFR4 signaling", "Signaling by FGFR4 in disease", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "P22459": ["Voltage gated Potassium channels"], "P22460": ["Voltage gated Potassium channels"], "P22466": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "P22528": ["Formation of the cornified envelope"], "P22531": ["Formation of the cornified envelope"], "P22532": ["Formation of the cornified envelope"], "P22557": ["Heme biosynthesis"], "P22570": ["Pregnenolone biosynthesis", "Endogenous sterols", "Electron transport from NADPH to Ferredoxin", "Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)"], "P22607": ["Signaling by activated point mutants of FGFR3", "FGFR3 mutant receptor activation", "t(4;14) translocations of FGFR3", "Signaling by FGFR3 fusions in cancer", "Signaling by FGFR3 point mutants in cancer"], "P22607-1": ["PI3K Cascade", "PIP3 activates AKT signaling", "Signaling by activated point mutants of FGFR3", "FGFR3c ligand binding and activation", "FGFR3 mutant receptor activation", "Constitutive Signaling by Aberrant PI3K in Cancer", "Phospholipase C-mediated cascade; FGFR3", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "PI-3K cascade:FGFR3", "Negative regulation of FGFR3 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Signaling by FGFR3 point mutants in cancer"], "P22607-2": ["PI3K Cascade", "PIP3 activates AKT signaling", "Signaling by activated point mutants of FGFR3", "FGFR3b ligand binding and activation", "FGFR3 mutant receptor activation", "Constitutive Signaling by Aberrant PI3K in Cancer", "Phospholipase C-mediated cascade; FGFR3", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "PI-3K cascade:FGFR3", "Negative regulation of FGFR3 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Signaling by FGFR3 point mutants in cancer"], "P22612": ["PKA-mediated phosphorylation of CREB", "PKA-mediated phosphorylation of key metabolic factors", "Triglyceride catabolism", "PKA activation", "PKA activation in glucagon signalling", "DARPP-32 events", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Rap1 signalling", "Regulation of insulin secretion", "Vasopressin regulates renal water homeostasis via Aquaporins", "VEGFA-VEGFR2 Pathway", "CREB1 phosphorylation through the activation of Adenylate Cyclase", "CREB1 phosphorylation through the activation of Adenylate Cyclase", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'off' state", "CD209 (DC-SIGN) signaling", "MAPK6/MAPK4 signaling", "Glycolysis", "RET signaling", "HDL assembly", "ROBO receptors bind AKAP5", "Factors involved in megakaryocyte development and platelet production"], "P22626": ["mRNA Splicing - Major Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "P22680": ["Synthesis of bile acids and bile salts", "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "PPARA activates gene expression", "Endogenous sterols"], "P22681": ["Interleukin-6 signaling", "Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "Spry regulation of FGF signaling", "Regulation of KIT signaling", "EGFR downregulation", "TGF-beta receptor signaling activates SMADs", "Constitutive Signaling by EGFRvIII", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "Negative regulation of MET activity", "PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "InlB-mediated entry of Listeria monocytogenes into host cell", "InlB-mediated entry of Listeria monocytogenes into host cell", "Regulation of signaling by CBL", "Regulation of signaling by CBL"], "P22692": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "P22694": ["PKA-mediated phosphorylation of CREB", "PKA-mediated phosphorylation of key metabolic factors", "Triglyceride catabolism", "PKA activation", "PKA activation in glucagon signalling", "DARPP-32 events", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Rap1 signalling", "Regulation of insulin secretion", "Vasopressin regulates renal water homeostasis via Aquaporins", "VEGFA-VEGFR2 Pathway", "CREB1 phosphorylation through the activation of Adenylate Cyclase", "CREB1 phosphorylation through the activation of Adenylate Cyclase", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'off' state", "CD209 (DC-SIGN) signaling", "MAPK6/MAPK4 signaling", "Glycolysis", "RET signaling", "HDL assembly", "ROBO receptors bind AKAP5", "Factors involved in megakaryocyte development and platelet production"], "P22695": ["Respiratory electron transport"], "P22732": ["Neutrophil degranulation", "Intestinal hexose absorption"], "P22735": ["Formation of the cornified envelope"], "P22736": ["AKT phosphorylates targets in the nucleus", "Nuclear Receptor transcription pathway", "Constitutive Signaling by AKT1 E17K in Cancer"], "P22748": ["Erythrocytes take up carbon dioxide and release oxygen", "Erythrocytes take up oxygen and release carbon dioxide", "Reversible hydration of carbon dioxide"], "P22749": ["Antimicrobial peptides"], "P22760": ["Phase I - Functionalization of compounds"], "P22792": ["Regulation of Complement cascade"], "P22830": ["Heme biosynthesis"], "P22888": ["Hormone ligand-binding receptors", "G alpha (s) signalling events"], "P22891": ["Gamma-carboxylation of protein precursors", "Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "Removal of aminoterminal propeptides from gamma-carboxylated proteins"], "P22894": ["Collagen degradation", "Degradation of the extracellular matrix", "Activation of Matrix Metalloproteinases", "Neutrophil degranulation"], "P22897": ["Cross-presentation of soluble exogenous antigens (endosomes)", "Cross-presentation of soluble exogenous antigens (endosomes)"], "P23025": ["Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER"], "P23083": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P23109": ["Purine salvage"], "P23141": ["Metabolism of Angiotensinogen to Angiotensins", "Phase I - Functionalization of compounds"], "P23142": ["Molecules associated with elastic fibres", "Molecules associated with elastic fibres"], "P23193": ["Formation of RNA Pol II elongation complex ", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "RNA Polymerase II Transcription Elongation"], "P23219": ["COX reactions", "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"], "P23229": ["Assembly of collagen fibrils and other multimeric structures", "Basigin interactions", "Integrin cell surface interactions", "Integrin cell surface interactions", "Laminin interactions", "Laminin interactions", "Syndecan interactions", "Type I hemidesmosome assembly"], "P23246": ["PTK6 Regulates Proteins Involved in RNA Processing"], "P23258": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "P23276": ["Peptide ligand-binding receptors"], "P23280": ["Reversible hydration of carbon dioxide"], "P23284": ["Collagen biosynthesis and modifying enzymes"], "P23297": ["Regulation of TLR by endogenous ligand"], "P23327": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "P23352": ["FGFR1c ligand binding and activation", "Negative regulation of FGFR1 signaling"], "P23368": ["Citric acid cycle (TCA cycle)"], "P23378": ["Glycine degradation"], "P23381": ["Cytosolic tRNA aminoacylation"], "P23396": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P23409": ["CDO in myogenesis", "CDO in myogenesis"], "P23415": ["Neurotransmitter receptors and postsynaptic signal transmission"], "P23416": ["Neurotransmitter receptors and postsynaptic signal transmission"], "P23434": ["Glyoxylate metabolism and glycine degradation", "Glycine degradation"], "P23443": ["mTORC1-mediated signalling"], "P23458": ["Interleukin-6 signaling", "Interleukin-6 signaling", "MAPK3 (ERK1) activation", "MAPK1 (ERK2) activation", "ISG15 antiviral mechanism", "Interleukin-7 signaling", "Interleukin-7 signaling", "Other interleukin signaling", "RAF/MAP kinase cascade", "Interleukin-10 signaling", "Interleukin-4 and Interleukin-13 signaling", "IL-6-type cytokine receptor ligand interactions", "Interferon gamma signaling", "Regulation of IFNG signaling", "Regulation of IFNG signaling", "Interleukin-20 family signaling", "Interleukin-15 signaling", "Interleukin-15 signaling", "Interleukin-35 Signalling", "Interleukin-9 signaling", "Interleukin-2 signaling", "Interleukin-12 signaling", "Interleukin-12 signaling", "Interleukin-27 signaling", "Interleukin-27 signaling", "Interleukin-21 signaling", "Interferon alpha/beta signaling", "Interleukin receptor SHC signaling", "Regulation of IFNA signaling", "Regulation of IFNA signaling"], "P23467": ["Neutrophil degranulation"], "P23468": ["Receptor-type tyrosine-protein phosphatases", "Synaptic adhesion-like molecules"], "P23471": ["Other interleukin signaling"], "P23490": ["Formation of the cornified envelope"], "P23497": ["SUMOylation of DNA damage response and repair proteins", "Interferon gamma signaling"], "P23510": ["TNFs bind their physiological receptors"], "P23511": ["PPARA activates gene expression", "Activation of gene expression by SREBF (SREBP)", "Activation of gene expression by SREBF (SREBP)", "ATF4 activates genes", "ATF6 (ATF6-alpha) activates chaperone genes", "FOXO-mediated transcription of cell death genes"], "P23515": ["Axonal growth inhibition (RHOA activation)"], "P23526": ["Methylation", "Sulfur amino acid metabolism", "Metabolism of ingested SeMet, Sec, MeSec into H2Se", "Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD)"], "P23527": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "HATs acetylate histones", "HATs acetylate histones", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Ub-specific processing proteases", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "E3 ubiquitin ligases ubiquitinate target proteins", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "P23528": ["Platelet degranulation ", "Regulation of actin dynamics for phagocytic cup formation", "EPHB-mediated forward signaling", "Sema3A PAK dependent Axon repulsion", "RHO GTPases Activate ROCKs", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "P23560": ["MECP2 regulates transcription of neuronal ligands", "BDNF activates NTRK2 (TRKB) signaling", "Activated NTRK2 signals through RAS", "Activated NTRK2 signals through PLCG1", "Activated NTRK2 signals through PLCG1", "Activated NTRK2 signals through PI3K", "Activated NTRK2 signals through FRS2 and FRS3", "Activated NTRK2 signals through FRS2 and FRS3", "Activated NTRK2 signals through FYN", "NTRK2 activates RAC1", "NTRK2 activates RAC1", "Activated NTRK2 signals through CDK5"], "P23582": ["Physiological factors"], "P23588": ["L13a-mediated translational silencing of Ceruloplasmin expression", "mTORC1-mediated signalling", "Deadenylation of mRNA", "Translation initiation complex formation", "Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "P23634": ["Reduction of cytosolic Ca++ levels", "Ion homeostasis", "Ion transport by P-type ATPases"], "P23677": ["Synthesis of IP3 and IP4 in the cytosol"], "P23743": ["Effects of PIP2 hydrolysis"], "P23760": ["HATs acetylate histones"], "P23763": ["Toxicity of botulinum toxin type D (BoNT/D)", "Toxicity of botulinum toxin type F (BoNT/F)", "Toxicity of botulinum toxin type G (BoNT/G)"], "P23769": ["RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Factors involved in megakaryocyte development and platelet production"], "P23771": ["Ub-specific processing proteases", "Interleukin-4 and Interleukin-13 signaling", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Factors involved in megakaryocyte development and platelet production"], "P23786": ["PPARA activates gene expression", "Import of palmitoyl-CoA into the mitochondrial matrix"], "P23919": ["Interconversion of nucleotide di- and triphosphates"], "P23921": ["Interconversion of nucleotide di- and triphosphates"], "P23945": ["Hormone ligand-binding receptors", "G alpha (s) signalling events"], "P23946": ["Signaling by SCF-KIT", "Activation of Matrix Metalloproteinases", "Metabolism of Angiotensinogen to Angiotensins"], "P23975": ["Na+/Cl- dependent neurotransmitter transporters", "Defective SLC6A2 causes orthostatic intolerance (OI)"], "P24001": ["Other interleukin signaling"], "P24043": ["Laminin interactions", "Laminin interactions", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "MET activates PTK2 signaling"], "P24046": ["GABA A (rho) receptor activation"], "P24071": ["Neutrophil degranulation"], "P24158": ["Common Pathway of Fibrin Clot Formation", "Other interleukin signaling", "Neutrophil degranulation", "Antimicrobial peptides"], "P24298": ["Amino acid synthesis and interconversion (transamination)"], "P24311": ["TP53 Regulates Metabolic Genes", "Respiratory electron transport"], "P24347": ["Collagen degradation", "Degradation of the extracellular matrix", "Activation of Matrix Metalloproteinases"], "P24385": ["SCF(Skp2)-mediated degradation of p27/p21", "Pre-NOTCH Transcription and Translation", "RMTs methylate histone arginines", "Interleukin-4 and Interleukin-13 signaling", "Ubiquitin-dependent degradation of Cyclin D1", "Ubiquitin-dependent degradation of Cyclin D1", "Cyclin D associated events in G1", "PTK6 Regulates Cell Cycle", "Transcriptional regulation by RUNX2", "Regulation of RUNX1 Expression and Activity", "RUNX3 regulates WNT signaling", "RUNX3 regulates p14-ARF", "Estrogen-dependent gene expression"], "P24386": ["TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "P24387": ["Class B/2 (Secretin family receptors)"], "P24390": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "P24394": ["Interleukin-4 and Interleukin-13 signaling"], "P24462": ["Xenobiotics"], "P24468": ["Transcriptional regulation of white adipocyte differentiation"], "P24522": ["TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "FOXO-mediated transcription of cell cycle genes"], "P24530": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "P24534": ["Eukaryotic Translation Elongation"], "P24539": ["Formation of ATP by chemiosmotic coupling", "Cristae formation"], "P24557": ["Eicosanoids", "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD)"], "P24588": ["Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Trafficking of AMPA receptors", "ROBO receptors bind AKAP5", "ROBO receptors bind AKAP5"], "P24592": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "P24593": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "P24723": ["Effects of PIP2 hydrolysis", "G alpha (z) signalling events"], "P24752": ["Branched-chain amino acid catabolism", "Utilization of Ketone Bodies", "Synthesis of Ketone Bodies"], "P24821": ["Integrin cell surface interactions", "Syndecan interactions", "ECM proteoglycans", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "P24844": ["EPHA-mediated growth cone collapse", "Sema4D induced cell migration and growth-cone collapse", "Smooth Muscle Contraction", "RHO GTPases activate PKNs", "RHO GTPases activate CIT", "RHO GTPases Activate ROCKs", "RHO GTPases activate PAKs", "RHO GTPases activate PAKs", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"], "P24863": ["PPARA activates gene expression", "NOTCH1 Intracellular Domain Regulates Transcription", "Generic Transcription Pathway", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "P24864": ["G0 and Early G1", "SCF(Skp2)-mediated degradation of p27/p21", "DNA Damage/Telomere Stress Induced Senescence", "Association of TriC/CCT with target proteins during biosynthesis", "Activation of E2F1 target genes at G1/S", "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "CDK-mediated phosphorylation and removal of Cdc6", "Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes", "Cyclin E associated events during G1/S transition ", "p53-Dependent G1 DNA Damage Response", "PTK6 Regulates Cell Cycle"], "P24903": ["Fatty acids", "Xenobiotics", "CYP2E1 reactions"], "P24928": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Abortive elongation of HIV-1 transcript in the absence of Tat", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "Viral Messenger RNA Synthesis", "MicroRNA (miRNA) biogenesis", "Transcriptional regulation of pluripotent stem cells", "Transcriptional regulation by small RNAs", "PIWI-interacting RNA (piRNA) biogenesis", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE", "Signaling by FGFR2 IIIa TM", "Estrogen-dependent gene expression"], "P24941": ["G0 and Early G1", "Activation of ATR in response to replication stress", "Regulation of APC/C activators between G1/S and early anaphase", "SCF(Skp2)-mediated degradation of p27/p21", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "Processing of DNA double-strand break ends", "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "Regulation of TP53 Activity through Phosphorylation", "Regulation of TP53 Degradation", "G2 Phase", "Orc1 removal from chromatin", "Activation of the pre-replicative complex", "CDK-mediated phosphorylation and removal of Cdc6", "Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes", "Cyclin E associated events during G1/S transition ", "Cyclin A/B1/B2 associated events during G2/M transition", "p53-Dependent G1 DNA Damage Response", "Cyclin A:Cdk2-associated events at S phase entry", "PTK6 Regulates Cell Cycle", "Meiotic recombination", "Factors involved in megakaryocyte development and platelet production"], "P25021": ["Histamine receptors", "G alpha (s) signalling events"], "P25024": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events", "Neutrophil degranulation"], "P25025": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events", "Neutrophil degranulation"], "P25054": ["Apoptotic cleavage of cellular proteins", "Degradation of beta-catenin by the destruction complex", "Beta-catenin phosphorylation cascade", "Deactivation of the beta-catenin transactivating complex", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Misspliced GSK3beta mutants stabilize beta-catenin", "S33 mutants of beta-catenin aren't phosphorylated", "S37 mutants of beta-catenin aren't phosphorylated", "S45 mutants of beta-catenin aren't phosphorylated", "T41 mutants of beta-catenin aren't phosphorylated", "APC truncation mutants are not K63 polyubiquitinated", "APC truncation mutants have impaired AXIN binding", "AXIN missense mutants destabilize the destruction complex", "Truncations of AMER1 destabilize the destruction complex", "Ovarian tumor domain proteases"], "P25063": ["L1CAM interactions"], "P25067": ["Collagen degradation", "Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "Collagen chain trimerization"], "P25089": ["G alpha (i) signalling events", "Formyl peptide receptors bind formyl peptides and many other ligands"], "P25090": ["G alpha (q) signalling events", "G alpha (i) signalling events", "Formyl peptide receptors bind formyl peptides and many other ligands", "Neutrophil degranulation"], "P25092": ["Digestion", "Intestinal infectious diseases"], "P25098": ["Calmodulin induced events", "G alpha (q) signalling events", "G alpha (s) signalling events", "Activation of SMO", "Activation of SMO", "Cargo recognition for clathrin-mediated endocytosis"], "P25100": ["Adrenoceptors", "G alpha (q) signalling events", "G alpha (12/13) signalling events"], "P25101": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "P25103": ["Tachykinin receptors bind tachykinins", "G alpha (q) signalling events", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "P25105": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (q) signalling events", "Interleukin-10 signaling", "Neutrophil degranulation", "Interferon gamma signaling"], "P25106": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "P25116": ["Common Pathway of Fibrin Clot Formation", "Peptide ligand-binding receptors", "G alpha (q) signalling events", "Thrombin signalling through proteinase activated receptors (PARs)", "Thrombin signalling through proteinase activated receptors (PARs)"], "P25147": ["InlB-mediated entry of Listeria monocytogenes into host cell", "InlB-mediated entry of Listeria monocytogenes into host cell"], "P25205": ["Activation of ATR in response to replication stress", "Unwinding of DNA", "Assembly of the pre-replicative complex", "Orc1 removal from chromatin", "Activation of the pre-replicative complex", "Switching of origins to a post-replicative state"], "P25208": ["PPARA activates gene expression", "Activation of gene expression by SREBF (SREBP)", "Activation of gene expression by SREBF (SREBP)", "ATF4 activates genes", "ATF6 (ATF6-alpha) activates chaperone genes", "FOXO-mediated transcription of cell death genes"], "P25311": ["Miscellaneous transport and binding events"], "P25325": ["Degradation of cysteine and homocysteine"], "P25391": ["Laminin interactions", "Laminin interactions", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "L1CAM interactions", "MET activates PTK2 signaling"], "P25398": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P25440": ["RUNX3 regulates p14-ARF"], "P25445": ["Caspase activation via Death Receptors in the presence of ligand", "Regulation by c-FLIP", "RIPK1-mediated regulated necrosis", "CASP8 activity is inhibited", "TP53 Regulates Transcription of Death Receptors and Ligands", "Dimerization of procaspase-8", "FasL/ CD95L signaling"], "P25490": ["Activation of anterior HOX genes in hindbrain development during early embryogenesis", "UCH proteinases", "DNA Damage Recognition in GG-NER", "TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "Estrogen-dependent gene expression"], "P25685": ["Regulation of HSF1-mediated heat shock response", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Attenuation phase", "HSF1-dependent transactivation", "MAPK6/MAPK4 signaling"], "P25705": ["Mitochondrial protein import", "Formation of ATP by chemiosmotic coupling", "Cristae formation"], "P25713": ["Metallothioneins bind metals", "Metallothioneins bind metals"], "P25774": ["Endosomal/Vacuolar pathway", "Degradation of the extracellular matrix", "Degradation of the extracellular matrix", "Trafficking and processing of endosomal TLR", "Assembly of collagen fibrils and other multimeric structures", "MHC class II antigen presentation", "Neutrophil degranulation"], "P25786": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "P25787": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "Neutrophil degranulation", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "P25788": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "P25789": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "P25791": ["RUNX1 regulates transcription of genes involved in differentiation of HSCs"], "P25800": ["RUNX1 regulates transcription of genes involved in differentiation of HSCs"], "P25815": ["Neutrophil degranulation"], "P25874": ["The fatty acid cycling model", "The proton buffering model"], "P25929": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "P25940": ["Collagen degradation", "Extracellular matrix organization", "Collagen biosynthesis and modifying enzymes", "Signaling by PDGF", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "Syndecan interactions", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "NCAM1 interactions", "MET activates PTK2 signaling", "Collagen chain trimerization"], "P25942-1": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "TNFR2 non-canonical NF-kB pathway", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "P25963": ["Activation of NF-kappaB in B cells", "RIP-mediated NFkB activation via ZBP1", "Downstream TCR signaling", "NF-kB is activated and signals survival", "FCERI mediated NF-kB activation", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "SUMOylation of immune response proteins", "IkBA variant leads to EDA-ID", "CLEC7A (Dectin-1) signaling", "Ub-specific processing proteases", "Interleukin-1 signaling", "TRAF6 mediated NF-kB activation"], "P26006": ["Basigin interactions", "Integrin cell surface interactions", "Integrin cell surface interactions", "Laminin interactions", "MET activates PTK2 signaling"], "P26010": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Integrin cell surface interactions"], "P26012": ["Molecules associated with elastic fibres", "Integrin cell surface interactions"], "P26022": ["Neutrophil degranulation"], "P26038": ["Recycling pathway of L1", "Recycling pathway of L1", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "P26045": ["EGFR downregulation"], "P26196": ["mRNA decay by 5' to 3' exoribonuclease"], "P26232": ["CDO in myogenesis", "CDO in myogenesis"], "P26358": ["PRC2 methylates histones and DNA", "NoRC negatively regulates rRNA expression", "SUMOylation of DNA methylation proteins", "DNA methylation"], "P26367": ["Regulation of gene expression in beta cells", "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)", "Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "P26368": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing"], "P26371": ["Keratinization"], "P26373": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P26374": ["RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "P26439": ["Androgen biosynthesis", "Mineralocorticoid biosynthesis", "Glucocorticoid biosynthesis"], "P26440": ["Branched-chain amino acid catabolism"], "P26441": ["IL-6-type cytokine receptor ligand interactions"], "P26572": ["N-glycan trimming and elongation in the cis-Golgi"], "P26583": ["Activation of DNA fragmentation factor"], "P26599": ["FGFR2 alternative splicing", "mRNA Splicing - Major Pathway", "Processing of Capped Intron-Containing Pre-mRNA"], "P26623": ["ER-Phagosome pathway", "MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "Toll Like Receptor TLR6:TLR2 Cascade", "MyD88 deficiency (TLR2/4)", "IRAK4 deficiency (TLR2/4)"], "P26639": ["Cytosolic tRNA aminoacylation"], "P26640": ["Cytosolic tRNA aminoacylation"], "P26641": ["Eukaryotic Translation Elongation"], "P26651": ["Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA"], "P26678": ["Ion homeostasis", "Ion transport by P-type ATPases"], "P26715": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "P26717": ["DAP12 interactions", "DAP12 signaling", "DAP12 signaling"], "P26718": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "DAP12 interactions", "DAP12 signaling", "DAP12 signaling"], "P26842": ["TNFs bind their physiological receptors"], "P26927": ["Signaling by MST1"], "P26951": ["Interleukin-3, Interleukin-5 and GM-CSF signaling", "RAF/MAP kinase cascade", "Interleukin receptor SHC signaling"], "P26992": ["IL-6-type cytokine receptor ligand interactions"], "P27037": ["Signaling by NODAL", "Regulation of signaling by NODAL", "Signaling by Activin", "Signaling by Activin", "Signaling by BMP"], "P27105": ["Stimuli-sensing channels", "Neutrophil degranulation"], "P27144": ["Interconversion of nucleotide di- and triphosphates"], "P27169": ["Synthesis of 5-eicosatetraenoic acids"], "P27338": ["Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB"], "P27348": ["Activation of BAD and translocation to mitochondria ", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "RHO GTPases activate PKNs", "TP53 Regulates Metabolic Genes", "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "Regulation of localization of FOXO transcription factors"], "P27352": ["Cobalamin (Cbl, vitamin B12) transport and metabolism", "Defective GIF causes intrinsic factor deficiency", "Defective AMN causes hereditary megaloblastic anemia 1", "Defective CUBN causes hereditary megaloblastic anemia 1"], "P27361": ["MAPK3 (ERK1) activation", "RAF-independent MAPK1/3 activation", "ISG15 antiviral mechanism", "Spry regulation of FGF signaling", "Frs2-mediated activation", "ERK/MAPK targets", "ERK/MAPK targets", "ERKs are inactivated", "Regulation of actin dynamics for phagocytic cup formation", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "Oncogene Induced Senescence", "Oncogene Induced Senescence", "FCERI mediated MAPK activation", "Regulation of HSF1-mediated heat shock response", "NCAM signaling for neurite out-growth", "RSK activation", "Signal transduction by L1", "Activation of the AP-1 family of transcription factors", "Thrombin signalling through proteinase activated receptors (PARs)", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate NADPH Oxidases", "RAF/MAP kinase cascade", "MAP2K and MAPK activation", "Negative feedback regulation of MAPK pathway", "Negative regulation of MAPK pathway", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "RNA Polymerase I Promoter Opening", "Signal attenuation", "Advanced glycosylation endproduct receptor signaling", "Gastrin-CREB signalling pathway via PKC and MAPK", "ESR-mediated signaling", "RUNX2 regulates osteoblast differentiation", "Regulation of PTEN gene transcription", "Regulation of the apoptosome activity", "Growth hormone receptor signaling"], "P27361-3": ["Golgi Cisternae Pericentriolar Stack Reorganization"], "P27448": ["RAF activation", "MAP2K and MAPK activation", "Negative regulation of MAPK pathway", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF"], "P27449": ["ROS, RNS production in phagocytes", "Neutrophil degranulation", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "P27469": ["PPARA activates gene expression"], "P27487": ["Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)"], "P27539": ["Signaling by NODAL"], "P27540": ["Regulation of gene expression by Hypoxia-inducible Factor", "PPARA activates gene expression", "Phase I - Functionalization of compounds", "Endogenous sterols", "Xenobiotics", "Aryl hydrocarbon receptor signalling"], "P27544": ["Sphingolipid de novo biosynthesis"], "P27635": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P27658": ["Collagen degradation", "Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "Collagen chain trimerization"], "P27694": ["Translesion synthesis by REV1", "Recognition of DNA damage by PCNA-containing replication complex", "Translesion Synthesis by POLH", "Removal of the Flap Intermediate from the C-strand", "Activation of ATR in response to replication stress", "SUMOylation of DNA damage response and repair proteins", "Regulation of HSF1-mediated heat shock response", "HSF1 activation", "Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "PCNA-Dependent Long Patch Base Excision Repair", "Translesion synthesis by POLK", "Translesion synthesis by POLI", "Termination of translesion DNA synthesis", "HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Formation of Incision Complex in GG-NER", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Fanconi Anemia Pathway", "Regulation of TP53 Activity through Phosphorylation", "Activation of the pre-replicative complex", "Removal of the Flap Intermediate", "G2/M DNA damage checkpoint", "Meiotic recombination"], "P27695": ["Displacement of DNA glycosylase by APEX1", "POLB-Dependent Long Patch Base Excision Repair", "Resolution of AP sites via the multiple-nucleotide patch replacement pathway", "PCNA-Dependent Long Patch Base Excision Repair", "Abasic sugar-phosphate removal via the single-nucleotide replacement pathway", "Resolution of Abasic Sites (AP sites)"], "P27707": ["Pyrimidine salvage", "Purine salvage"], "P27708": ["Pyrimidine biosynthesis"], "P27797": ["ER-Phagosome pathway", "Assembly of Viral Components at the Budding Site", "Scavenging by Class A Receptors", "Scavenging by Class A Receptors", "Scavenging by Class F Receptors", "Scavenging by Class F Receptors", "ATF6 (ATF6-alpha) activates chaperone genes", "Calnexin/calreticulin cycle", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P27815": ["DARPP-32 events", "G alpha (s) signalling events"], "P27824": ["Assembly of Viral Components at the Budding Site", "MHC class II antigen presentation", "Interleukin-35 Signalling", "Calnexin/calreticulin cycle", "Interleukin-27 signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P27918": ["Alternative complement activation", "Activation of C3 and C5", "Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins", "Neutrophil degranulation", "Regulation of Complement cascade"], "P27930": ["Interleukin-10 signaling", "Interleukin-1 signaling"], "P27958": ["TBC/RABGAPs"], "P27986": ["PI3K Cascade", "IRS-mediated signalling", "GPVI-mediated activation cascade", "Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "PI3K events in ERBB4 signaling", "PIP3 activates AKT signaling", "Interleukin-7 signaling", "Interleukin-7 signaling", "Signaling by SCF-KIT", "Synthesis of PIPs at the plasma membrane", "GAB1 signalosome", "Signaling by cytosolic FGFR1 fusion mutants", "Downstream signal transduction", "PI3K events in ERBB2 signaling", "PI3K/AKT activation", "Downstream TCR signaling", "Role of phospholipids in phagocytosis", "Tie2 Signaling", "Constitutive Signaling by Aberrant PI3K in Cancer", "DAP12 signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Nephrin family interactions", "Costimulation by the CD28 family", "CD28 dependent PI3K/Akt signaling", "G alpha (q) signalling events", "GP1b-IX-V activation signalling", "VEGFA-VEGFR2 Pathway", "VEGFA-VEGFR2 Pathway", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "Constitutive Signaling by EGFRvIII", "PI-3K cascade:FGFR1", "PI-3K cascade:FGFR2", "PI-3K cascade:FGFR3", "PI-3K cascade:FGFR4", "Signaling by FGFR2 in disease", "Signaling by FGFR4 in disease", "Signaling by FGFR1 in disease", "Interleukin-4 and Interleukin-13 signaling", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "MET activates PI3K/AKT signaling", "Signaling by FGFR3 fusions in cancer", "Signaling by FGFR3 point mutants in cancer", "RET signaling", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "Activated NTRK2 signals through PI3K", "Interleukin receptor SHC signaling", "Regulation of signaling by CBL", "Regulation of signaling by CBL", "Activated NTRK3 signals through PI3K", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P27987": ["Synthesis of IP3 and IP4 in the cytosol"], "P28062": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Interferon alpha/beta signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "P28065": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "P28066": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "Neutrophil degranulation", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "P28067": ["MHC class II antigen presentation"], "P28068": ["MHC class II antigen presentation"], "P28070": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "P28072": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "P28074": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "P28161": ["Glutathione conjugation"], "P28221": ["Serotonin receptors", "G alpha (i) signalling events"], "P28222": ["Serotonin receptors", "G alpha (i) signalling events"], "P28223": ["Serotonin receptors", "G alpha (q) signalling events"], "P28288": ["ABC transporters in lipid homeostasis"], "P28289": ["Striated Muscle Contraction"], "P28300": ["Elastic fibre formation", "Crosslinking of collagen fibrils"], "P28328": ["E3 ubiquitin ligases ubiquitinate target proteins", "Peroxisomal protein import", "Peroxisomal protein import"], "P28329": ["Synthesis of PC", "Acetylcholine Neurotransmitter Release Cycle"], "P28330": ["Beta oxidation of myristoyl-CoA to lauroyl-CoA", "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids", "Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA"], "P28331": ["Respiratory electron transport", "Complex I biogenesis"], "P28332": ["Ethanol oxidation"], "P28335": ["Serotonin receptors", "G alpha (q) signalling events"], "P28336": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "P28340": ["Recognition of DNA damage by PCNA-containing replication complex", "Polymerase switching on the C-strand of the telomere", "Processive synthesis on the C-strand of the telomere", "Telomere C-strand (Lagging Strand) Synthesis", "Removal of the Flap Intermediate from the C-strand", "Cytosolic iron-sulfur cluster assembly", "Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "PCNA-Dependent Long Patch Base Excision Repair", "Termination of translesion DNA synthesis", "HDR through Homologous Recombination (HRR)", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Polymerase switching", "Removal of the Flap Intermediate", "Processive synthesis on the lagging strand"], "P28347": ["YAP1- and WWTR1 (TAZ)-stimulated gene expression", "RUNX3 regulates YAP1-mediated transcription"], "P28472": ["GABA A receptor activation", "GABA receptor activation"], "P28476": ["GABA A (rho) receptor activation"], "P28482": ["phospho-PLA2 pathway", "RAF-independent MAPK1/3 activation", "MAPK1 (ERK2) activation", "Spry regulation of FGF signaling", "Golgi Cisternae Pericentriolar Stack Reorganization", "Frs2-mediated activation", "ERK/MAPK targets", "ERK/MAPK targets", "ERKs are inactivated", "Regulation of actin dynamics for phagocytic cup formation", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "Oncogene Induced Senescence", "Oncogene Induced Senescence", "FCERI mediated MAPK activation", "Regulation of HSF1-mediated heat shock response", "NCAM signaling for neurite out-growth", "Recycling pathway of L1", "RSK activation", "Signal transduction by L1", "Activation of the AP-1 family of transcription factors", "Thrombin signalling through proteinase activated receptors (PARs)", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate NADPH Oxidases", "RAF/MAP kinase cascade", "MAP2K and MAPK activation", "Negative feedback regulation of MAPK pathway", "Negative regulation of MAPK pathway", "Neutrophil degranulation", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Signal attenuation", "Advanced glycosylation endproduct receptor signaling", "Gastrin-CREB signalling pathway via PKC and MAPK", "ESR-mediated signaling", "RUNX2 regulates osteoblast differentiation", "Regulation of PTEN gene transcription", "Regulation of the apoptosome activity", "Growth hormone receptor signaling"], "P28562": ["RAF-independent MAPK1/3 activation", "Negative regulation of MAPK pathway"], "P28566": ["Serotonin receptors", "G alpha (i) signalling events"], "P28676": ["Neutrophil degranulation"], "P28702": ["PPARA activates gene expression", "Nuclear Receptor transcription pathway", "Signaling by Retinoic Acid"], "P28715": ["Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER"], "P28749": ["Transcription of E2F targets under negative control by DREAM complex", "Transcription of E2F targets under negative control by DREAM complex", "Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1", "G0 and Early G1", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Activation of E2F1 target genes at G1/S", "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "Cyclin D associated events in G1"], "P28799": ["Neutrophil degranulation"], "P28845": ["Glucocorticoid biosynthesis"], "P28906-1": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "P28907": ["Nicotinate metabolism"], "P28908": ["TNFs bind their physiological receptors"], "P29016": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "P29017": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "P29033": ["Oligomerization of connexins into connexons", "Transport of connexins along the secretory pathway", "Gap junction assembly", "Transport of connexons to the plasma membrane"], "P29074": ["Toll Like Receptor 4 (TLR4) Cascade", "Interleukin-37 signaling", "MECP2 regulates neuronal receptors and channels"], "P29083": ["HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "RNA Polymerase II Pre-transcription Events", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "P29084": ["HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "RNA Polymerase II Pre-transcription Events", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "P29120": ["Peptide hormone biosynthesis", "Insulin processing", "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)", "Synthesis, secretion, and deacylation of Ghrelin"], "P29122": ["Signaling by NODAL", "NGF processing", "Formation of the cornified envelope", "Assembly of active LPL and LIPC lipase complexes"], "P29144": ["Antigen processing: Ubiquitination & Proteasome degradation"], "P29218": ["Synthesis of IP2, IP, and Ins in the cytosol"], "P29274": ["NGF-independant TRKA activation", "Adenosine P1 receptors", "G alpha (s) signalling events", "Surfactant metabolism"], "P29275": ["Adenosine P1 receptors", "G alpha (s) signalling events", "Surfactant metabolism"], "P29279": ["YAP1- and WWTR1 (TAZ)-stimulated gene expression", "RUNX3 regulates YAP1-mediated transcription"], "P29317": ["EPH-Ephrin signaling", "EPH-Ephrin signaling", "EPHA-mediated growth cone collapse", "EPHA-mediated growth cone collapse", "EPH-ephrin mediated repulsion of cells", "EPH-ephrin mediated repulsion of cells"], "P29320": ["EPH-Ephrin signaling", "EPH-Ephrin signaling", "EPHA-mediated growth cone collapse", "EPHA-mediated growth cone collapse", "EPH-ephrin mediated repulsion of cells", "EPH-ephrin mediated repulsion of cells"], "P29322": ["EPH-Ephrin signaling", "EPH-Ephrin signaling", "EPHA-mediated growth cone collapse", "EPHA-mediated growth cone collapse", "EPH-ephrin mediated repulsion of cells", "EPH-ephrin mediated repulsion of cells"], "P29323": ["EPH-Ephrin signaling", "EPH-Ephrin signaling", "L1CAM interactions", "EPHB-mediated forward signaling", "EPHB-mediated forward signaling", "Ephrin signaling", "Ephrin signaling", "EPH-ephrin mediated repulsion of cells"], "P29350": ["GPVI-mediated activation cascade", "Regulation of KIT signaling", "PECAM1 interactions", "Costimulation by the CD28 family", "PD-1 signaling", "Signal regulatory protein family interactions", "Platelet sensitization by LDL", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "CD22 mediated BCR regulation", "Neutrophil degranulation", "Interferon gamma signaling", "Regulation of IFNG signaling", "Interleukin-37 signaling", "Interferon alpha/beta signaling", "Interleukin receptor SHC signaling", "Regulation of IFNA signaling", "Growth hormone receptor signaling", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P29353": ["Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "SHC1 events in ERBB2 signaling", "SHC1 events in ERBB2 signaling", "SHC1 events in ERBB4 signaling", "Signalling to RAS", "Signalling to RAS", "SHC1 events in EGFR signaling", "Tie2 Signaling", "Integrin alphaIIb beta3 signaling", "XBP1(S) activates chaperone genes", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "Constitutive Signaling by EGFRvIII", "RAF/MAP kinase cascade", "Signal attenuation", "Insulin receptor signalling cascade", "Insulin receptor signalling cascade", "RET signaling", "Interleukin-15 signaling", "Interleukin-15 signaling", "Interleukin-2 signaling", "Erythropoietin activates RAS", "Erythropoietin activates RAS", "Interleukin receptor SHC signaling"], "P29353-1": ["SHC1 events in ERBB2 signaling", "SHC-related events triggered by IGF1R", "SHC-related events triggered by IGF1R"], "P29353-2": ["SHC1 events in ERBB2 signaling", "DAP12 signaling", "SHC-related events triggered by IGF1R", "SHC-related events triggered by IGF1R", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "SHC-mediated cascade:FGFR1", "SHC-mediated cascade:FGFR2", "SHC-mediated cascade:FGFR3", "SHC-mediated cascade:FGFR4", "RAF/MAP kinase cascade", "MET activates RAS signaling", "Activated NTRK2 signals through RAS", "Activated NTRK3 signals through RAS"], "P29353-3": ["SHC-related events triggered by IGF1R", "SHC-related events triggered by IGF1R", "SHC-mediated cascade:FGFR1", "SHC-mediated cascade:FGFR2", "SHC-mediated cascade:FGFR3", "SHC-mediated cascade:FGFR4", "RAF/MAP kinase cascade", "Activated NTRK2 signals through RAS", "Activated NTRK3 signals through RAS"], "P29371": ["Tachykinin receptors bind tachykinins", "G alpha (q) signalling events"], "P29372": ["Recognition and association of DNA glycosylase with site containing an affected purine", "Cleavage of the damaged purine", "Displacement of DNA glycosylase by APEX1"], "P29373": ["Signaling by Retinoic Acid"], "P29374": ["HDACs deacetylate histones"], "P29375": ["HDMs demethylate histones"], "P29400": ["Collagen degradation", "Collagen degradation", "Extracellular matrix organization", "Collagen biosynthesis and modifying enzymes", "Signaling by PDGF", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "Integrin cell surface interactions", "Anchoring fibril formation", "Crosslinking of collagen fibrils", "Laminin interactions", "Laminin interactions", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "NCAM1 interactions", "Collagen chain trimerization", "Regulation of expression of SLITs and ROBOs"], "P29401": ["Insulin effects increased synthesis of Xylulose-5-Phosphate", "Pentose phosphate pathway"], "P29459": ["Interleukin-10 signaling", "Interleukin-4 and Interleukin-13 signaling", "Interleukin-35 Signalling", "Interleukin-12 signaling", "Interleukin-12 signaling"], "P29460": ["Interleukin-10 signaling", "Interleukin-4 and Interleukin-13 signaling", "Interleukin-12 signaling", "Interleukin-12 signaling", "Interleukin-23 signaling", "Interleukin-23 signaling"], "P29466": ["NOD1/2 Signaling Pathway", "Interleukin-1 processing", "TP53 Regulates Transcription of Caspase Activators and Caspases", "The NLRP3 inflammasome", "The AIM2 inflammasome", "The IPAF inflammasome", "Interleukin-37 signaling"], "P29474": ["ROS, RNS production in phagocytes", "Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "eNOS activation", "NOSTRIN mediated eNOS trafficking", "NOSIP mediated eNOS trafficking", "Nitric oxide stimulates guanylate cyclase", "VEGFR2 mediated vascular permeability"], "P29475": ["ROS, RNS production in phagocytes", "Nitric oxide stimulates guanylate cyclase", "Ion homeostasis"], "P29508": ["Neutrophil degranulation"], "P29536": ["Smooth Muscle Contraction"], "P29590": ["SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Regulation of TP53 Activity through Acetylation", "Interferon gamma signaling", "Regulation of RUNX1 Expression and Activity", "Regulation of PTEN localization"], "P29597": ["Interleukin-6 signaling", "Interleukin-6 signaling", "MAPK3 (ERK1) activation", "MAPK1 (ERK2) activation", "Other interleukin signaling", "Interleukin-10 signaling", "Interleukin-4 and Interleukin-13 signaling", "IL-6-type cytokine receptor ligand interactions", "Interleukin-20 family signaling", "Interleukin-35 Signalling", "Interleukin-12 signaling", "Interleukin-12 signaling", "Interleukin-23 signaling", "Interleukin-23 signaling", "Interleukin-27 signaling", "Interleukin-27 signaling", "Interferon alpha/beta signaling", "Regulation of IFNA signaling", "Regulation of IFNA signaling"], "P29622": ["Platelet degranulation "], "P29692": ["Eukaryotic Translation Elongation"], "P29728": ["Interferon gamma signaling", "OAS antiviral response", "Interferon alpha/beta signaling"], "P29762": ["RA biosynthesis pathway"], "P29803": ["Regulation of pyruvate dehydrogenase (PDH) complex", "Glyoxylate metabolism and glycine degradation", "Signaling by Retinoic Acid", "Pyruvate metabolism"], "P29965": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "TNFR2 non-canonical NF-kB pathway", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "P29966": ["Acetylcholine regulates insulin secretion"], "P29972": ["Erythrocytes take up carbon dioxide and release oxygen", "Erythrocytes take up oxygen and release carbon dioxide", "Vasopressin regulates renal water homeostasis via Aquaporins", "Passive transport by Aquaporins"], "P29973": ["Activation of the phototransduction cascade", "Inactivation, recovery and regulation of the phototransduction cascade"], "P29992": ["Acetylcholine regulates insulin secretion", "Acetylcholine regulates insulin secretion", "G alpha (q) signalling events", "G alpha (q) signalling events", "ADP signalling through P2Y purinoceptor 1", "ADP signalling through P2Y purinoceptor 1", "Thromboxane signalling through TP receptor", "Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "Thrombin signalling through proteinase activated receptors (PARs)"], "P30038": ["Glyoxylate metabolism and glycine degradation", "Proline catabolism"], "P30041": ["Detoxification of Reactive Oxygen Species", "Neutrophil degranulation"], "P30043": ["Heme degradation"], "P30044-1": ["Detoxification of Reactive Oxygen Species"], "P30044-2": ["Detoxification of Reactive Oxygen Species", "TP53 Regulates Metabolic Genes"], "P30047": ["Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation"], "P30048": ["Detoxification of Reactive Oxygen Species"], "P30049": ["Formation of ATP by chemiosmotic coupling", "Cristae formation"], "P30050": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P30084": ["Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "Beta oxidation of butanoyl-CoA to acetyl-CoA"], "P30085": ["Interconversion of nucleotide di- and triphosphates"], "P30086": ["MAP2K and MAPK activation", "Negative regulation of MAPK pathway", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF"], "P30101": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Calnexin/calreticulin cycle", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P30153": ["Inhibition of replication initiation of damaged DNA by RB1/E2F1", "Spry regulation of FGF signaling", "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Integration of energy metabolism", "PP2A-mediated dephosphorylation of key metabolic factors", "DARPP-32 events", "Degradation of beta-catenin by the destruction complex", "Beta-catenin phosphorylation cascade", "ERK/MAPK targets", "ERKs are inactivated", "MASTL Facilitates Mitotic Progression", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Regulation of PLK1 Activity at G2/M Transition", "Initiation of Nuclear Envelope Reformation", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "CTLA4 inhibitory signaling", "Platelet sensitization by LDL", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Misspliced GSK3beta mutants stabilize beta-catenin", "S33 mutants of beta-catenin aren't phosphorylated", "S37 mutants of beta-catenin aren't phosphorylated", "S45 mutants of beta-catenin aren't phosphorylated", "T41 mutants of beta-catenin aren't phosphorylated", "APC truncation mutants have impaired AXIN binding", "AXIN missense mutants destabilize the destruction complex", "Truncations of AMER1 destabilize the destruction complex", "Anchoring of the basal body to the plasma membrane", "RHO GTPases Activate Formins", "RAF activation", "Negative regulation of MAPK pathway", "Regulation of TP53 Degradation", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Mitotic Prometaphase", "Cyclin D associated events in G1", "Cyclin A/B1/B2 associated events during G2/M transition", "Glycolysis", "AURKA Activation by TPX2", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P30154": ["Inhibition of replication initiation of damaged DNA by RB1/E2F1", "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Integration of energy metabolism", "PP2A-mediated dephosphorylation of key metabolic factors", "DARPP-32 events", "Degradation of beta-catenin by the destruction complex", "Beta-catenin phosphorylation cascade", "ERK/MAPK targets", "ERKs are inactivated", "MASTL Facilitates Mitotic Progression", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "CTLA4 inhibitory signaling", "Platelet sensitization by LDL", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Misspliced GSK3beta mutants stabilize beta-catenin", "S33 mutants of beta-catenin aren't phosphorylated", "S37 mutants of beta-catenin aren't phosphorylated", "S45 mutants of beta-catenin aren't phosphorylated", "T41 mutants of beta-catenin aren't phosphorylated", "APC truncation mutants have impaired AXIN binding", "AXIN missense mutants destabilize the destruction complex", "Truncations of AMER1 destabilize the destruction complex", "RHO GTPases Activate Formins", "RAF activation", "Negative regulation of MAPK pathway", "Regulation of TP53 Degradation", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Mitotic Prometaphase", "Cyclin D associated events in G1", "Cyclin A/B1/B2 associated events during G2/M transition", "Glycolysis"], "P30260": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6", "Antigen processing: Ubiquitination & Proteasome degradation"], "P30273": ["GPVI-mediated activation cascade", "Cell surface interactions at the vascular wall", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "Dectin-2 family", "Dectin-2 family", "Neutrophil degranulation", "Platelet Adhesion to exposed collagen"], "P30279": ["Cyclin D associated events in G1", "Regulation of RUNX1 Expression and Activity"], "P30281": ["Transcriptional regulation of white adipocyte differentiation", "MAPK6/MAPK4 signaling", "Cyclin D associated events in G1", "Regulation of RUNX1 Expression and Activity"], "P30291": ["Polo-like kinase mediated events", "Cyclin E associated events during G1/S transition ", "Cyclin A/B1/B2 associated events during G2/M transition", "Cyclin A/B1/B2 associated events during G2/M transition", "G2/M DNA replication checkpoint", "Cyclin A:Cdk2-associated events at S phase entry", "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "Factors involved in megakaryocyte development and platelet production"], "P30301": ["Passive transport by Aquaporins"], "P30304": ["Transcription of E2F targets under negative control by DREAM complex", "Polo-like kinase mediated events", "Activation of ATR in response to replication stress", "Ub-specific processing proteases", "Cyclin E associated events during G1/S transition ", "Cyclin A/B1/B2 associated events during G2/M transition", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "Cyclin A:Cdk2-associated events at S phase entry", "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models"], "P30305": ["Cyclin A/B1/B2 associated events during G2/M transition", "Cyclin A:Cdk2-associated events at S phase entry", "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models"], "P30307": ["Polo-like kinase mediated events", "Activation of ATR in response to replication stress", "RHO GTPases activate PKNs", "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "Cyclin A/B1/B2 associated events during G2/M transition", "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models"], "P30411": ["Peptide ligand-binding receptors", "G alpha (q) signalling events", "G alpha (i) signalling events"], "P30419": ["Late Phase of HIV Life Cycle", "Inactivation, recovery and regulation of the phototransduction cascade", "Activation, myristolyation of BID and translocation to mitochondria"], "P30443": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P30447": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P30450": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P30453": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P30455": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P30456": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P30457": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P30459": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P30460": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P30461": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P30462": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P30464": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P30466": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P30475": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P30479": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P30480": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P30481": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P30483": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P30484": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P30485": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P30486": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P30487": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P30488": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P30490": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P30491": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P30492": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P30493": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P30495": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P30498": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P30499": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P30501": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P30504": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "DAP12 interactions", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P30505": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P30508": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P30510": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P30511": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P30512": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P30518": ["Vasopressin-like receptors", "G alpha (s) signalling events", "Vasopressin regulates renal water homeostasis via Aquaporins", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI)"], "P30519": ["Heme degradation", "Neutrophil degranulation", "Iron uptake and transport"], "P30520": ["Purine ribonucleoside monophosphate biosynthesis"], "P30530": ["VEGFA-VEGFR2 Pathway"], "P30531": ["Na+/Cl- dependent neurotransmitter transporters", "Reuptake of GABA"], "P30532": ["Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "Highly calcium permeable nicotinic acetylcholine receptors"], "P30536": ["Pregnenolone biosynthesis"], "P30542": ["Adenosine P1 receptors", "G alpha (i) signalling events"], "P30550": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "P30556": ["Peptide ligand-binding receptors", "G alpha (q) signalling events", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "P30559": ["Vasopressin-like receptors", "G alpha (q) signalling events"], "P30566": ["Purine ribonucleoside monophosphate biosynthesis"], "P30613-1": ["ChREBP activates metabolic gene expression", "Glycolysis"], "P30613-2": ["Regulation of gene expression in beta cells", "Glycolysis"], "P30622": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "P30626": ["Stimuli-sensing channels", "Reduction of cytosolic Ca++ levels", "Sodium/Calcium exchangers", "Ion homeostasis", "Ion transport by P-type ATPases"], "P30679": ["Acetylcholine regulates insulin secretion", "Acetylcholine regulates insulin secretion", "G alpha (q) signalling events", "G alpha (q) signalling events", "ADP signalling through P2Y purinoceptor 1", "ADP signalling through P2Y purinoceptor 1", "Thromboxane signalling through TP receptor", "Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "Thrombin signalling through proteinase activated receptors (PARs)"], "P30685": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P30690": ["ER-Phagosome pathway", "MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "Toll Like Receptor TLR1:TLR2 Cascade", "MyD88 deficiency (TLR2/4)", "IRAK4 deficiency (TLR2/4)"], "P30711": ["Glutathione conjugation"], "P30740": ["Neutrophil degranulation"], "P30793": ["Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation"], "P30825": ["Amino acid transport across the plasma membrane"], "P30837": ["Ethanol oxidation"], "P30838": ["Phase I - Functionalization of compounds"], "P30872": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "P30874": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "P30876": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Abortive elongation of HIV-1 transcript in the absence of Tat", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "Viral Messenger RNA Synthesis", "MicroRNA (miRNA) biogenesis", "Transcriptional regulation of pluripotent stem cells", "Transcriptional regulation by small RNAs", "PIWI-interacting RNA (piRNA) biogenesis", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE", "Signaling by FGFR2 IIIa TM", "Estrogen-dependent gene expression"], "P30926": ["Highly sodium permeable acetylcholine nicotinic receptors", "Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "Highly calcium permeable nicotinic acetylcholine receptors", "Neutrophil degranulation"], "P30939": ["Serotonin receptors", "G alpha (i) signalling events"], "P30953": ["Olfactory Signaling Pathway"], "P30954": ["Olfactory Signaling Pathway"], "P30968": ["Hormone ligand-binding receptors", "G alpha (q) signalling events"], "P30988": ["G alpha (s) signalling events", "Calcitonin-like ligand receptors"], "P30989": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "P30990": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "P30996": ["Toxicity of botulinum toxin type F (BoNT/F)"], "P31025": ["Transport of fatty acids"], "P31040": ["Respiratory electron transport", "Citric acid cycle (TCA cycle)"], "P31150": ["Rho GTPase cycle", "RAB GEFs exchange GTP for GDP on RABs"], "P31151": ["Neutrophil degranulation", "Metal sequestration by antimicrobial proteins"], "P31152": ["MAPK6/MAPK4 signaling"], "P31153": ["Methylation"], "P31213": ["Androgen biosynthesis"], "P31249": ["Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "P31321": ["PKA activation", "PKA activation in glucagon signalling", "DARPP-32 events", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Vasopressin regulates renal water homeostasis via Aquaporins", "CREB1 phosphorylation through the activation of Adenylate Cyclase", "Hedgehog 'off' state", "Factors involved in megakaryocyte development and platelet production"], "P31323": ["PKA activation", "PKA activation in glucagon signalling", "DARPP-32 events", "Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Vasopressin regulates renal water homeostasis via Aquaporins", "CREB1 phosphorylation through the activation of Adenylate Cyclase", "Hedgehog 'off' state", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2", "Factors involved in megakaryocyte development and platelet production"], "P31327": ["Urea cycle"], "P31350": ["Interconversion of nucleotide di- and triphosphates", "Activation of E2F1 target genes at G1/S", "Transcriptional Regulation by E2F6"], "P31358": ["Post-translational modification: synthesis of GPI-anchored proteins"], "P31371": ["PI3K Cascade", "PIP3 activates AKT signaling", "Signaling by activated point mutants of FGFR1", "Signaling by activated point mutants of FGFR3", "FGFR4 ligand binding and activation", "FGFR3b ligand binding and activation", "FGFR3c ligand binding and activation", "FGFR1c ligand binding and activation", "FGFR2c ligand binding and activation", "FGFR3 mutant receptor activation", "Activated point mutants of FGFR2", "Constitutive Signaling by Aberrant PI3K in Cancer", "Phospholipase C-mediated cascade: FGFR1", "Phospholipase C-mediated cascade; FGFR2", "Phospholipase C-mediated cascade; FGFR3", "Phospholipase C-mediated cascade; FGFR4", "Downstream signaling of activated FGFR1", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "PI-3K cascade:FGFR3", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "PI-3K cascade:FGFR4", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "Signaling by FGFR2 in disease", "Signaling by FGFR1 in disease", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Signaling by FGFR3 point mutants in cancer"], "P31391": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "P31415": ["Stimuli-sensing channels", "Ion homeostasis"], "P31431": ["A tetrasaccharide linker sequence is required for GAG synthesis", "HS-GAG biosynthesis", "HS-GAG biosynthesis", "HS-GAG degradation", "Cell surface interactions at the vascular wall", "Syndecan interactions", "Syndecan interactions", "Defective B4GALT7 causes EDS, progeroid type", "Defective B3GAT3 causes JDSSDHD", "Defective EXT2 causes exostoses 2", "Defective EXT1 causes exostoses 1, TRPS2 and CHDS", "Defective B3GALT6 causes EDSP2 and SEMDJL1", "Retinoid metabolism and transport"], "P31483": ["FGFR2 alternative splicing"], "P31513": ["FMO oxidises nucleophiles", "Defective FMO3 causes Trimethylaminuria (TMAU)"], "P31639": ["Cellular hexose transport", "Defective SLC5A2 causes renal glucosuria (GLYS1)"], "P31641": ["Amino acid transport across the plasma membrane", "Na+/Cl- dependent neurotransmitter transporters"], "P31644": ["GABA A receptor activation", "GABA receptor activation"], "P31645": ["Serotonin clearance from the synaptic cleft"], "P31689": ["HSP90 chaperone cycle for steroid hormone receptors (SHR)"], "P31749": ["Activation of BAD and translocation to mitochondria ", "PIP3 activates AKT signaling", "PIP3 activates AKT signaling", "Downregulation of ERBB2:ERBB3 signaling", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "mTOR signalling", "AKT phosphorylates targets in the cytosol", "AKT phosphorylates targets in the cytosol", "AKT phosphorylates targets in the nucleus", "Negative regulation of the PI3K/AKT network", "eNOS activation", "AKT-mediated inactivation of FOXO1A", "Integrin alphaIIb beta3 signaling", "Deactivation of the beta-catenin transactivating complex", "CD28 dependent PI3K/Akt signaling", "CTLA4 inhibitory signaling", "G beta:gamma signalling through PI3Kgamma", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "KSRP (KHSRP) binds and destabilizes mRNA", "VEGFR2 mediated vascular permeability", "TP53 Regulates Metabolic Genes", "Constitutive Signaling by AKT1 E17K in Cancer", "Interleukin-4 and Interleukin-13 signaling", "Regulation of TP53 Degradation", "Regulation of TP53 Activity through Acetylation", "Regulation of TP53 Activity through Association with Co-factors", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Cyclin E associated events during G1/S transition ", "Cyclin A:Cdk2-associated events at S phase entry", "PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "RAB GEFs exchange GTP for GDP on RABs", "RUNX2 regulates genes involved in cell migration", "Regulation of PTEN stability and activity", "Negative regulation of NOTCH4 signaling", "Regulation of localization of FOXO transcription factors"], "P31751": ["Activation of BAD and translocation to mitochondria ", "PIP3 activates AKT signaling", "PIP3 activates AKT signaling", "Downregulation of ERBB2:ERBB3 signaling", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Activation of AKT2", "PDE3B signalling", "Inhibition of TSC complex formation by PKB", "AKT phosphorylates targets in the cytosol", "AKT phosphorylates targets in the cytosol", "AKT phosphorylates targets in the nucleus", "Negative regulation of the PI3K/AKT network", "AKT-mediated inactivation of FOXO1A", "Deactivation of the beta-catenin transactivating complex", "CD28 dependent PI3K/Akt signaling", "CTLA4 inhibitory signaling", "G beta:gamma signalling through PI3Kgamma", "VEGFR2 mediated vascular permeability", "TP53 Regulates Metabolic Genes", "Constitutive Signaling by AKT1 E17K in Cancer", "Regulation of TP53 Degradation", "Regulation of TP53 Activity through Acetylation", "Regulation of TP53 Activity through Association with Co-factors", "Cyclin E associated events during G1/S transition ", "Cyclin A:Cdk2-associated events at S phase entry", "RAB GEFs exchange GTP for GDP on RABs", "RUNX2 regulates genes involved in cell migration", "Regulation of PTEN stability and activity", "Regulation of localization of FOXO transcription factors"], "P31785": ["Interleukin-7 signaling", "Interleukin-7 signaling", "RAF/MAP kinase cascade", "Interleukin-4 and Interleukin-13 signaling", "Interleukin-15 signaling", "Interleukin-15 signaling", "Interleukin-9 signaling", "Interleukin-2 signaling", "Interleukin-21 signaling", "Interleukin receptor SHC signaling"], "P31819": ["Dectin-2 family"], "P31872": ["Dectin-2 family"], "P31930": ["Respiratory electron transport"], "P31937": ["Branched-chain amino acid catabolism"], "P31939": ["Purine ribonucleoside monophosphate biosynthesis"], "P31941": ["mRNA Editing: C to U Conversion", "Formation of the Editosome"], "P31943": ["FGFR2 alternative splicing", "mRNA Splicing - Major Pathway", "Processing of Capped Intron-Containing Pre-mRNA"], "P31944": ["Formation of the cornified envelope"], "P31946": ["Activation of BAD and translocation to mitochondria ", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "mTOR signalling", "mTORC1-mediated signalling", "Frs2-mediated activation", "ARMS-mediated activation", "Signaling by Hippo", "Rap1 signalling", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "RHO GTPases activate PKNs", "TP53 Regulates Metabolic Genes", "RAF activation", "MAP2K and MAPK activation", "Negative regulation of MAPK pathway", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF", "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "Regulation of localization of FOXO transcription factors"], "P31947": ["Activation of BAD and translocation to mitochondria ", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "RHO GTPases activate PKNs", "TP53 Regulates Metabolic Genes", "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "Regulation of localization of FOXO transcription factors"], "P31948": ["HSP90 chaperone cycle for steroid hormone receptors (SHR)"], "P31949": ["Neutrophil degranulation"], "P31994": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "P31997": ["Fibronectin matrix formation", "Cell surface interactions at the vascular wall", "Neutrophil degranulation"], "P32004": ["Basigin interactions", "L1CAM interactions", "L1CAM interactions", "Recycling pathway of L1", "Recycling pathway of L1", "Interaction between L1 and Ankyrins", "Interaction between L1 and Ankyrins", "Signal transduction by L1"], "P32019": ["Synthesis of IP2, IP, and Ins in the cytosol", "Synthesis of IP3 and IP4 in the cytosol", "Rho GTPase cycle"], "P32119": ["Detoxification of Reactive Oxygen Species", "TP53 Regulates Metabolic Genes", "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models"], "P32121": ["Activated NOTCH1 Transmits Signal to the Nucleus", "G alpha (s) signalling events", "Thrombin signalling through proteinase activated receptors (PARs)", "WNT5A-dependent internalization of FZD4", "Activation of SMO", "Activation of SMO", "MAP2K and MAPK activation", "Ub-specific processing proteases", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "P32189": ["Triglyceride biosynthesis"], "P32238": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "P32239": ["Peptide ligand-binding receptors", "G alpha (q) signalling events", "Gastrin-CREB signalling pathway via PKC and MAPK"], "P32241": ["G alpha (s) signalling events", "Glucagon-type ligand receptors"], "P32245": ["Peptide ligand-binding receptors", "G alpha (s) signalling events"], "P32246": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events", "Interleukin-10 signaling"], "P32247": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "P32248": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "P32249": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (i) signalling events"], "P32297": ["Highly sodium permeable acetylcholine nicotinic receptors", "Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "Highly calcium permeable nicotinic acetylcholine receptors"], "P32298-1": ["Inactivation, recovery and regulation of the phototransduction cascade"], "P32302": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "P32320": ["Neutrophil degranulation", "Pyrimidine salvage"], "P32321": ["Interconversion of nucleotide di- and triphosphates"], "P32322": ["Amino acid synthesis and interconversion (transamination)"], "P32418": ["Reduction of cytosolic Ca++ levels", "Sodium/Calcium exchangers", "Ion homeostasis"], "P32455": ["Interferon gamma signaling"], "P32456": ["Interferon gamma signaling", "Interferon alpha/beta signaling"], "P32519": ["RUNX1 regulates transcription of genes involved in BCR signaling", "RUNX1 regulates transcription of genes involved in interleukin signaling"], "P32745": ["Peptide ligand-binding receptors", "G alpha (i) signalling events", "BBSome-mediated cargo-targeting to cilium"], "P32754": ["Phenylalanine and tyrosine catabolism"], "P32780": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Tat-mediated elongation of the HIV-1 transcript", "NoRC negatively regulates rRNA expression", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "mRNA Capping", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase I Transcription Termination", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE"], "P32881": ["Interferon alpha/beta signaling", "Regulation of IFNA signaling", "Regulation of IFNA signaling", "TRAF6 mediated IRF7 activation", "Factors involved in megakaryocyte development and platelet production"], "P32926": ["Apoptotic cleavage of cell adhesion proteins", "Keratinization", "Formation of the cornified envelope"], "P32927": ["Interleukin-3, Interleukin-5 and GM-CSF signaling", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "RAF/MAP kinase cascade", "Surfactant metabolism", "Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5)", "Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)", "Interleukin receptor SHC signaling"], "P32929": ["Degradation of cysteine and homocysteine", "Cysteine formation from homocysteine", "Metabolism of ingested SeMet, Sec, MeSec into H2Se"], "P32942": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Integrin cell surface interactions", "CD209 (DC-SIGN) signaling"], "P32969": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P32970": ["TNFs bind their physiological receptors"], "P32971": ["TNFs bind their physiological receptors"], "P33032": ["Peptide ligand-binding receptors", "G alpha (s) signalling events"], "P33076": ["Interferon gamma signaling"], "P33121": ["PPARA activates gene expression", "Linoleic acid (LA) metabolism", "alpha-linolenic acid (ALA) metabolism", "Synthesis of very long-chain fatty acyl-CoAs"], "P33151": ["Adherens junctions interactions", "VEGFR2 mediated vascular permeability"], "P33176": ["MHC class II antigen presentation", "Insulin processing", "RHO GTPases activate KTN1", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "P33240": ["Cleavage of Growing Transcript in the Termination Region ", "tRNA processing in the nucleus", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "P33260": ["Xenobiotics"], "P33261": ["Xenobiotics", "CYP2E1 reactions", "Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)", "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)"], "P33316-2": ["Interconversion of nucleotide di- and triphosphates"], "P33402": ["Nitric oxide stimulates guanylate cyclase", "Smooth Muscle Contraction"], "P33527": ["Cobalamin (Cbl, vitamin B12) transport and metabolism", "Synthesis of Leukotrienes (LT) and Eoxins (EX)", "ABC-family proteins mediated transport"], "P33681": ["PIP3 activates AKT signaling", "Constitutive Signaling by Aberrant PI3K in Cancer", "CD28 co-stimulation", "CD28 dependent PI3K/Akt signaling", "CD28 dependent Vav1 pathway", "CTLA4 inhibitory signaling", "Interleukin-10 signaling", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "P33778": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "HATs acetylate histones", "HATs acetylate histones", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Ub-specific processing proteases", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "E3 ubiquitin ligases ubiquitinate target proteins", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "P33897": ["ABC transporters in lipid homeostasis", "Linoleic acid (LA) metabolism", "alpha-linolenic acid (ALA) metabolism", "Beta-oxidation of very long chain fatty acids", "Defective ABCD1 causes adrenoleukodystrophy (ALD)"], "P33908": ["Intra-Golgi traffic", "Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2"], "P33947": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "P33991": ["Activation of ATR in response to replication stress", "Unwinding of DNA", "Assembly of the pre-replicative complex", "Orc1 removal from chromatin", "Activation of the pre-replicative complex", "Switching of origins to a post-replicative state"], "P33992": ["Activation of ATR in response to replication stress", "Unwinding of DNA", "Assembly of the pre-replicative complex", "Orc1 removal from chromatin", "Activation of the pre-replicative complex", "Switching of origins to a post-replicative state"], "P33993": ["Activation of ATR in response to replication stress", "Unwinding of DNA", "Assembly of the pre-replicative complex", "Orc1 removal from chromatin", "Activation of the pre-replicative complex", "Switching of origins to a post-replicative state"], "P34059": ["Keratan sulfate degradation", "MPS IV - Morquio syndrome A", "Neutrophil degranulation"], "P34130": ["NTF4 activates NTRK2 (TRKB) signaling", "Activated NTRK2 signals through RAS", "Activated NTRK2 signals through PLCG1", "Activated NTRK2 signals through PLCG1", "Activated NTRK2 signals through PI3K", "Activated NTRK2 signals through FRS2 and FRS3", "Activated NTRK2 signals through FRS2 and FRS3"], "P34741": ["A tetrasaccharide linker sequence is required for GAG synthesis", "HS-GAG biosynthesis", "HS-GAG biosynthesis", "HS-GAG degradation", "Cell surface interactions at the vascular wall", "Syndecan interactions", "Syndecan interactions", "Defective B4GALT7 causes EDS, progeroid type", "Defective B3GAT3 causes JDSSDHD", "Defective EXT2 causes exostoses 2", "Defective EXT1 causes exostoses 1, TRPS2 and CHDS", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "EPHB-mediated forward signaling", "Defective B3GALT6 causes EDSP2 and SEMDJL1", "Post-translational protein phosphorylation", "Retinoid metabolism and transport"], "P34810": ["Neutrophil degranulation"], "P34896": ["Metabolism of folate and pterines", "Carnitine synthesis"], "P34897": ["Metabolism of folate and pterines"], "P34903": ["GABA A receptor activation", "GABA receptor activation"], "P34913": ["Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)", "Biosynthesis of maresins", "Peroxisomal protein import", "Peroxisomal protein import"], "P34925": ["TCF dependent signaling in response to WNT", "PCP/CE pathway"], "P34931": ["Regulation of HSF1-mediated heat shock response", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Attenuation phase", "HSF1-dependent transactivation"], "P34932": ["Regulation of HSF1-mediated heat shock response"], "P34947": ["G alpha (q) signalling events", "G alpha (s) signalling events"], "P34949": ["Defective MPI causes MPI-CDG (CDG-1b)", "Synthesis of GDP-mannose"], "P34969": ["Serotonin receptors", "G alpha (s) signalling events"], "P34972": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (i) signalling events"], "P34981": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "P34982": ["Olfactory Signaling Pathway"], "P34995": ["Prostanoid ligand receptors", "G alpha (q) signalling events"], "P34998": ["Class B/2 (Secretin family receptors)", "G alpha (s) signalling events"], "P35030": ["Alpha-defensins", "Cobalamin (Cbl, vitamin B12) transport and metabolism", "Neutrophil degranulation", "Antimicrobial peptides"], "P35052": ["A tetrasaccharide linker sequence is required for GAG synthesis", "HS-GAG biosynthesis", "HS-GAG biosynthesis", "HS-GAG degradation", "Cell surface interactions at the vascular wall", "Defective B4GALT7 causes EDS, progeroid type", "Defective B3GAT3 causes JDSSDHD", "Defective EXT2 causes exostoses 2", "Defective EXT1 causes exostoses 1, TRPS2 and CHDS", "Signaling by ROBO receptors", "Defective B3GALT6 causes EDSP2 and SEMDJL1", "Retinoid metabolism and transport"], "P35070": ["Signaling by ERBB2", "Signaling by ERBB4", "SHC1 events in ERBB2 signaling", "SHC1 events in ERBB2 signaling", "PI3K events in ERBB4 signaling", "SHC1 events in ERBB4 signaling", "Nuclear signaling by ERBB4", "PIP3 activates AKT signaling", "Signaling by EGFR", "GRB2 events in EGFR signaling", "GAB1 signalosome", "SHC1 events in EGFR signaling", "EGFR downregulation", "GRB2 events in ERBB2 signaling", "PI3K events in ERBB2 signaling", "EGFR interacts with phospholipase C-gamma", "Constitutive Signaling by Aberrant PI3K in Cancer", "Inhibition of Signaling by Overexpressed EGFR", "RAF/MAP kinase cascade", "ERBB2 Regulates Cell Motility", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "ERBB2 Activates PTK6 Signaling", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "Downregulation of ERBB2 signaling"], "P35080": ["Signaling by ROBO receptors", "RHO GTPases Activate Formins", "RHO GTPases Activate Formins"], "P35212": ["Gap junction assembly"], "P35218": ["Reversible hydration of carbon dioxide"], "P35221": ["CDO in myogenesis", "CDO in myogenesis", "Adherens junctions interactions", "VEGFR2 mediated vascular permeability", "RHO GTPases activate IQGAPs"], "P35222": ["Degradation of beta-catenin by the destruction complex", "Beta-catenin phosphorylation cascade", "TCF dependent signaling in response to WNT", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "Apoptotic cleavage of cell adhesion proteins", "CDO in myogenesis", "CDO in myogenesis", "Deactivation of the beta-catenin transactivating complex", "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "Ca2+ pathway", "Adherens junctions interactions", "Binding of TCF/LEF:CTNNB1 to target gene promoters", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "VEGFR2 mediated vascular permeability", "Misspliced GSK3beta mutants stabilize beta-catenin", "S33 mutants of beta-catenin aren't phosphorylated", "S37 mutants of beta-catenin aren't phosphorylated", "S45 mutants of beta-catenin aren't phosphorylated", "T41 mutants of beta-catenin aren't phosphorylated", "RHO GTPases activate IQGAPs", "InlA-mediated entry of Listeria monocytogenes into host cells", "RUNX3 regulates WNT signaling"], "P35225": ["Interleukin-4 and Interleukin-13 signaling", "Interleukin-18 signaling"], "P35226": ["Oxidative Stress Induced Senescence", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of transcription cofactors", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA methylation proteins", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription", "Transcriptional Regulation by E2F6"], "P35227": ["SUMOylation of DNA damage response and repair proteins", "SUMOylation of transcription cofactors", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA methylation proteins", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Transcriptional Regulation by E2F6"], "P35228": ["ROS, RNS production in phagocytes", "Nitric oxide stimulates guanylate cyclase", "Interleukin-4 and Interleukin-13 signaling", "Peroxisomal protein import", "Peroxisomal protein import"], "P35232": ["RAF activation", "Signaling by moderate kinase activity BRAF mutants", "Signaling by RAS mutants", "Paradoxical activation of RAF signaling by kinase inactive BRAF", "Processing of SMDT1"], "P35236": ["Interleukin-37 signaling"], "P35237": ["Neutrophil degranulation", "Dissolution of Fibrin Clot"], "P35240": ["Regulation of actin dynamics for phagocytic cup formation", "RHO GTPases activate PAKs"], "P35241": ["Recycling pathway of L1", "Recycling pathway of L1"], "P35243": ["Inactivation, recovery and regulation of the phototransduction cascade", "Inactivation, recovery and regulation of the phototransduction cascade"], "P35244": ["Translesion synthesis by REV1", "Recognition of DNA damage by PCNA-containing replication complex", "Translesion Synthesis by POLH", "Removal of the Flap Intermediate from the C-strand", "Activation of ATR in response to replication stress", "Regulation of HSF1-mediated heat shock response", "HSF1 activation", "Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "PCNA-Dependent Long Patch Base Excision Repair", "Translesion synthesis by POLK", "Translesion synthesis by POLI", "Termination of translesion DNA synthesis", "HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Formation of Incision Complex in GG-NER", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Fanconi Anemia Pathway", "Regulation of TP53 Activity through Phosphorylation", "Activation of the pre-replicative complex", "Removal of the Flap Intermediate", "G2/M DNA damage checkpoint", "Meiotic recombination"], "P35247": ["Toll Like Receptor 4 (TLR4) Cascade", "Toll Like Receptor TLR1:TLR2 Cascade", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Signal regulatory protein family interactions", "Surfactant metabolism", "Regulation of TLR by endogenous ligand", "Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5)", "Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)"], "P35249": ["Translesion synthesis by REV1", "Recognition of DNA damage by PCNA-containing replication complex", "Translesion Synthesis by POLH", "Polymerase switching on the C-strand of the telomere", "Activation of ATR in response to replication stress", "PCNA-Dependent Long Patch Base Excision Repair", "Translesion synthesis by POLK", "Translesion synthesis by POLI", "Termination of translesion DNA synthesis", "HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Regulation of TP53 Activity through Phosphorylation", "Polymerase switching", "G2/M DNA damage checkpoint"], "P35250": ["Translesion synthesis by REV1", "Recognition of DNA damage by PCNA-containing replication complex", "Translesion Synthesis by POLH", "Polymerase switching on the C-strand of the telomere", "Activation of ATR in response to replication stress", "PCNA-Dependent Long Patch Base Excision Repair", "Translesion synthesis by POLK", "Translesion synthesis by POLI", "Termination of translesion DNA synthesis", "HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Regulation of TP53 Activity through Phosphorylation", "Polymerase switching", "G2/M DNA damage checkpoint"], "P35251": ["Translesion synthesis by REV1", "Recognition of DNA damage by PCNA-containing replication complex", "Translesion Synthesis by POLH", "Polymerase switching on the C-strand of the telomere", "PCNA-Dependent Long Patch Base Excision Repair", "Translesion synthesis by POLK", "Translesion synthesis by POLI", "Termination of translesion DNA synthesis", "HDR through Homologous Recombination (HRR)", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Polymerase switching"], "P35268": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P35269": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Abortive elongation of HIV-1 transcript in the absence of Tat", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "Viral Messenger RNA Synthesis", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE", "Signaling by FGFR2 IIIa TM", "Estrogen-dependent gene expression"], "P35270": ["Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "eNOS activation"], "P35318": ["G alpha (s) signalling events", "Calcitonin-like ligand receptors"], "P35321": ["Formation of the cornified envelope"], "P35325": ["Formation of the cornified envelope"], "P35326": ["Formation of the cornified envelope"], "P35346": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "P35348": ["Adrenoceptors", "G alpha (q) signalling events", "G alpha (12/13) signalling events"], "P35354": ["Nicotinamide salvaging", "Synthesis of 15-eicosatetraenoic acid derivatives", "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "Interleukin-10 signaling", "Interleukin-4 and Interleukin-13 signaling", "Biosynthesis of DHA-derived SPMs", "Biosynthesis of EPA-derived SPMs", "Biosynthesis of DPAn-3 SPMs", "Biosynthesis of electrophilic \u03c9-3 PUFA oxo-derivatives"], "P35367": ["Histamine receptors", "G alpha (q) signalling events"], "P35368": ["Adrenoceptors", "G alpha (q) signalling events", "G alpha (12/13) signalling events"], "P35372": ["Opioid Signalling", "G-protein activation", "Peptide ligand-binding receptors", "G alpha (i) signalling events", "Interleukin-4 and Interleukin-13 signaling", "MECP2 regulates neuronal receptors and channels"], "P35398": ["RORA activates gene expression", "RORA activates gene expression", "PPARA activates gene expression", "Nuclear Receptor transcription pathway", "Circadian Clock", "Circadian Clock", "SUMOylation of intracellular receptors", "Interleukin-4 and Interleukin-13 signaling"], "P35408": ["Prostanoid ligand receptors", "G alpha (s) signalling events"], "P35414": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "P35442": ["Signaling by PDGF", "Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "P35443": ["Signaling by PDGF"], "P35462": ["Dopamine receptors", "G alpha (i) signalling events"], "P35475": ["HS-GAG degradation", "CS/DS degradation", "MPS I - Hurler syndrome"], "P35498": ["Interaction between L1 and Ankyrins", "Phase 0 - rapid depolarisation"], "P35499": ["Interaction between L1 and Ankyrins", "Phase 0 - rapid depolarisation"], "P35503": ["Glucuronidation"], "P35504": ["Glucuronidation"], "P35520": ["Cysteine formation from homocysteine", "Metabolism of ingested SeMet, Sec, MeSec into H2Se"], "P35523": ["Stimuli-sensing channels"], "P35527": ["Keratinization", "Formation of the cornified envelope"], "P35548": ["Regulation of RUNX2 expression and activity"], "P35555": ["Degradation of the extracellular matrix", "Degradation of the extracellular matrix", "Elastic fibre formation", "Molecules associated with elastic fibres", "Molecules associated with elastic fibres", "Integrin cell surface interactions", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "P35556": ["Degradation of the extracellular matrix", "Elastic fibre formation", "Molecules associated with elastic fibres", "Molecules associated with elastic fibres"], "P35557": ["Regulation of Glucokinase by Glucokinase Regulatory Protein", "Regulation of gene expression in beta cells", "Defective GCK causes maturity-onset diabetes of the young 2 (MODY2)", "Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)", "Glycolysis", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes"], "P35558": ["Abacavir metabolism", "Transcriptional regulation of white adipocyte differentiation", "Gluconeogenesis", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes"], "P35568": ["PI3K Cascade", "IRS-mediated signalling", "SOS-mediated signalling", "SOS-mediated signalling", "PIP3 activates AKT signaling", "Interleukin-7 signaling", "PI3K/AKT activation", "PI3K/AKT activation", "Constitutive Signaling by Aberrant PI3K in Cancer", "IRS-related events triggered by IGF1R", "Signaling by Leptin", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "IRS activation", "Signal attenuation", "Activated NTRK3 signals through PI3K", "Growth hormone receptor signaling"], "P35573": ["Neutrophil degranulation", "Glycogen breakdown (glycogenolysis)"], "P35575": ["Glycogen storage disease type Ia (G6PC)", "Gluconeogenesis", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes"], "P35579": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Regulation of actin dynamics for phagocytic cup formation", "EPHA-mediated growth cone collapse", "Sema4D induced cell migration and growth-cone collapse", "RHO GTPases activate PKNs", "RHO GTPases activate CIT", "RHO GTPases Activate ROCKs", "RHO GTPases activate PAKs", "RHO GTPases activate PAKs"], "P35580": ["EPHA-mediated growth cone collapse", "Sema4D induced cell migration and growth-cone collapse", "RHO GTPases activate PKNs", "RHO GTPases activate CIT", "RHO GTPases Activate ROCKs", "RHO GTPases activate PAKs", "RHO GTPases activate PAKs"], "P35606": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "P35609": ["Platelet degranulation ", "Nephrin family interactions", "Striated Muscle Contraction", "Unblocking of NMDA receptors, glutamate binding and activation", "Unblocking of NMDA receptors, glutamate binding and activation", "Ras activation upon Ca2+ influx through NMDA receptor", "RAF/MAP kinase cascade", "Negative regulation of NMDA receptor-mediated neuronal transmission", "Long-term potentiation"], "P35610": ["LDL clearance"], "P35611": ["Caspase-mediated cleavage of cytoskeletal proteins", "XBP1(S) activates chaperone genes", "Miscellaneous transport and binding events"], "P35612": ["Miscellaneous transport and binding events"], "P35613": ["Degradation of the extracellular matrix", "Basigin interactions", "Integrin cell surface interactions", "Proton-coupled monocarboxylate transport", "Pyruvate metabolism"], "P35625": ["Platelet degranulation "], "P35626": ["G alpha (s) signalling events", "Cargo recognition for clathrin-mediated endocytosis"], "P35637": ["mRNA Splicing - Major Pathway"], "P35638": ["ATF4 activates genes", "ATF6 (ATF6-alpha) activates chaperone genes", "FOXO-mediated transcription of cell death genes", "FOXO-mediated transcription of cell death genes"], "P35658": ["ISG15 antiviral mechanism", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "HuR (ELAVL1) binds and stabilizes mRNA", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "tRNA processing in the nucleus"], "P35659": ["B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors"], "P35670": ["Ion transport by P-type ATPases"], "P35680": ["Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "Regulation of gene expression in early pancreatic precursor cells"], "P35712": ["Deactivation of the beta-catenin transactivating complex"], "P35749": ["EPHA-mediated growth cone collapse", "Sema4D induced cell migration and growth-cone collapse", "Smooth Muscle Contraction", "RHO GTPases activate PKNs", "RHO GTPases activate CIT", "RHO GTPases Activate ROCKs", "RHO GTPases activate PAKs", "RHO GTPases activate PAKs"], "P35754": ["Interconversion of nucleotide di- and triphosphates"], "P35790": ["Synthesis of PC", "Synthesis of PE"], "P35813": ["Downregulation of SMAD2/3:SMAD4 transcriptional activity", "Energy dependent regulation of mTOR by LKB1-AMPK"], "P35858": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "P35869": ["PPARA activates gene expression", "Phase I - Functionalization of compounds", "Endogenous sterols", "Xenobiotics", "Aryl hydrocarbon receptor signalling"], "P35900": ["Keratinization", "Formation of the cornified envelope"], "P35908": ["Keratinization", "Formation of the cornified envelope"], "P35913": ["Activation of the phototransduction cascade", "Activation of the phototransduction cascade", "Inactivation, recovery and regulation of the phototransduction cascade", "Ca2+ pathway", "Ca2+ pathway"], "P35914": ["Synthesis of Ketone Bodies", "Peroxisomal protein import", "Peroxisomal protein import"], "P35916": ["VEGF binds to VEGFR leading to receptor dimerization", "NOTCH4 Intracellular Domain Regulates Transcription"], "P35961": ["Dectin-2 family"], "P35968": ["Neurophilin interactions with VEGF and VEGFR", "VEGF binds to VEGFR leading to receptor dimerization", "Integrin cell surface interactions", "VEGFA-VEGFR2 Pathway", "VEGFA-VEGFR2 Pathway", "VEGFR2 mediated cell proliferation"], "P35998": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "Neutrophil degranulation", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "P36021": ["Transport of organic anions"], "P36222": ["Neutrophil degranulation"], "P36269": ["Glutathione synthesis and recycling", "Synthesis of Leukotrienes (LT) and Eoxins (EX)", "Aflatoxin activation and detoxification"], "P36382": ["Gap junction assembly"], "P36383": ["Electric Transmission Across Gap Junctions", "Gap junction assembly"], "P36402": ["Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "Deactivation of the beta-catenin transactivating complex", "Ca2+ pathway", "Binding of TCF/LEF:CTNNB1 to target gene promoters", "Repression of WNT target genes", "Repression of WNT target genes", "RUNX3 regulates WNT signaling"], "P36404": ["Post-chaperonin tubulin folding pathway", "Regulation of insulin secretion"], "P36405": ["Trafficking of myristoylated proteins to the cilium"], "P36507": ["MAPK1 (ERK2) activation", "Signal transduction by L1", "Uptake and function of anthrax toxins", "RAF activation", "MAP2K and MAPK activation", "Negative feedback regulation of MAPK pathway", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF"], "P36537": ["Glucuronidation"], "P36542": ["Formation of ATP by chemiosmotic coupling", "Cristae formation"], "P36543": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "P36544": ["Highly calcium permeable postsynaptic nicotinic acetylcholine receptors"], "P36551": ["Heme biosynthesis"], "P36578": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P36639-1": ["Phosphate bond hydrolysis by NUDT proteins"], "P36639-2": ["Phosphate bond hydrolysis by NUDT proteins"], "P36639-3": ["Phosphate bond hydrolysis by NUDT proteins"], "P36639-4": ["Phosphate bond hydrolysis by NUDT proteins"], "P36871": ["Glycogen synthesis", "Defective PGM1 causes PGM1-CDG (CDG1t)", "Neutrophil degranulation", "Glycogen breakdown (glycogenolysis)", "Galactose catabolism"], "P36873": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Triglyceride catabolism", "Downregulation of TGF-beta receptor signaling", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Circadian Clock", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "P36888": ["PI3K Cascade", "Other interleukin signaling", "RAF/MAP kinase cascade"], "P36894": ["Signaling by BMP"], "P36896": ["Signaling by NODAL", "Regulation of signaling by NODAL", "Signaling by Activin"], "P36897": ["Downregulation of TGF-beta receptor signaling", "Downregulation of TGF-beta receptor signaling", "TGF-beta receptor signaling activates SMADs", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "SMAD2/3 Phosphorylation Motif Mutants in Cancer", "SMAD2/3 MH2 Domain Mutants in Cancer", "TGFBR2 Kinase Domain Mutants in Cancer", "TGFBR1 KD Mutants in Cancer", "TGFBR1 LBD Mutants in Cancer", "UCH proteinases", "Ub-specific processing proteases"], "P36941": ["TNFR2 non-canonical NF-kB pathway", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "P36954": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Abortive elongation of HIV-1 transcript in the absence of Tat", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "Viral Messenger RNA Synthesis", "MicroRNA (miRNA) biogenesis", "Transcriptional regulation of pluripotent stem cells", "Transcriptional regulation by small RNAs", "PIWI-interacting RNA (piRNA) biogenesis", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE", "Signaling by FGFR2 IIIa TM", "Estrogen-dependent gene expression"], "P36956": ["RORA activates gene expression", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes"], "P36956-1": ["Regulation of cholesterol biosynthesis by SREBP (SREBF)", "Regulation of cholesterol biosynthesis by SREBP (SREBF)", "PPARA activates gene expression", "Activation of gene expression by SREBF (SREBP)", "Activation of gene expression by SREBF (SREBP)", "Transcriptional regulation of white adipocyte differentiation"], "P36956-3": ["Regulation of cholesterol biosynthesis by SREBP (SREBF)", "Regulation of cholesterol biosynthesis by SREBP (SREBF)", "PPARA activates gene expression", "Activation of gene expression by SREBF (SREBP)", "Activation of gene expression by SREBF (SREBP)"], "P36957": ["Glyoxylate metabolism and glycine degradation", "Lysine catabolism", "Citric acid cycle (TCA cycle)"], "P36959": ["Purine salvage"], "P36969": ["Synthesis of 5-eicosatetraenoic acids", "Synthesis of 12-eicosatetraenoic acid derivatives", "Synthesis of 15-eicosatetraenoic acid derivatives"], "P36969-2": ["Biosynthesis of D-series resolvins", "Biosynthesis of E-series 18(S)-resolvins", "Biosynthesis of aspirin-triggered D-series resolvins", "Biosynthesis of E-series 18(R)-resolvins"], "P36980": ["Regulation of Complement cascade"], "P37023": ["Signaling by BMP"], "P37058": ["Androgen biosynthesis", "Synthesis of very long-chain fatty acyl-CoAs"], "P37059": ["Estrogen biosynthesis"], "P37088": ["Stimuli-sensing channels"], "P37108": ["SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Neutrophil degranulation"], "P37173": ["Downregulation of TGF-beta receptor signaling", "Downregulation of TGF-beta receptor signaling", "TGF-beta receptor signaling activates SMADs", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "SMAD2/3 Phosphorylation Motif Mutants in Cancer", "SMAD2/3 MH2 Domain Mutants in Cancer", "TGFBR2 MSI Frameshift Mutants in Cancer", "TGFBR2 Kinase Domain Mutants in Cancer", "TGFBR1 KD Mutants in Cancer", "TGFBR1 LBD Mutants in Cancer", "UCH proteinases"], "P37198": ["ISG15 antiviral mechanism", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "tRNA processing in the nucleus"], "P37231": ["PPARA activates gene expression", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation", "Nuclear Receptor transcription pathway", "SUMOylation of intracellular receptors", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription", "MECP2 regulates transcription factors"], "P37268": ["Cholesterol biosynthesis", "PPARA activates gene expression", "Activation of gene expression by SREBF (SREBP)"], "P37275": ["Interleukin-4 and Interleukin-13 signaling"], "P37287": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "P37288": ["Vasopressin-like receptors", "G alpha (q) signalling events", "Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI)"], "P37802": ["Platelet degranulation "], "P37837": ["Insulin effects increased synthesis of Xylulose-5-Phosphate", "TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P", "TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P", "Pentose phosphate pathway", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "P37840": ["Amyloid fiber formation"], "P38117": ["Respiratory electron transport", "Protein methylation"], "P38159": ["mRNA Splicing - Major Pathway", "Processing of Capped Intron-Containing Pre-mRNA"], "P38398": ["Meiotic synapsis", "SUMOylation of DNA damage response and repair proteins", "HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Metalloprotease DUBs", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Nonhomologous End-Joining (NHEJ)", "Homologous DNA Pairing and Strand Exchange", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "TP53 Regulates Transcription of DNA Repair Genes", "Regulation of TP53 Activity through Phosphorylation", "G2/M DNA damage checkpoint", "Transcriptional Regulation by E2F6", "Meiotic recombination"], "P38405": ["Adenylate cyclase activating pathway", "Adenylate cyclase inhibitory pathway", "Olfactory Signaling Pathway"], "P38435": ["Gamma-carboxylation of protein precursors", "Gamma-carboxylation of protein precursors"], "P38484": ["Interferon gamma signaling", "Regulation of IFNG signaling", "Regulation of IFNG signaling"], "P38567": ["Interaction With Cumulus Cells"], "P38570": ["Integrin cell surface interactions"], "P38571": ["LDL clearance"], "P38606": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "P38646": ["Mitochondrial protein import", "Regulation of HSF1-mediated heat shock response", "Cristae formation", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "P38919": ["Cleavage of Growing Transcript in the Termination Region ", "ISG15 antiviral mechanism", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Deadenylation of mRNA", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P38936": ["SCF(Skp2)-mediated degradation of p27/p21", "AKT phosphorylates targets in the cytosol", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "Constitutive Signaling by AKT1 E17K in Cancer", "Interleukin-4 and Interleukin-13 signaling", "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "Cyclin E associated events during G1/S transition ", "Cyclin D associated events in G1", "p53-Dependent G1 DNA Damage Response", "Cyclin A:Cdk2-associated events at S phase entry", "Transcriptional activation of cell cycle inhibitor p21 ", "The role of GTSE1 in G2/M progression after G2 checkpoint", "TFAP2 (AP-2) family regulates transcription of cell cycle factors", "Transcriptional regulation by RUNX2", "RUNX3 regulates CDKN1A transcription", "FOXO-mediated transcription of cell cycle genes"], "P39019": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P39023": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P39059": ["Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Assembly of collagen fibrils and other multimeric structures", "Collagen chain trimerization"], "P39060": ["Collagen degradation", "Activation of Matrix Metalloproteinases", "Collagen biosynthesis and modifying enzymes", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "Laminin interactions", "Collagen chain trimerization"], "P39086": ["Activation of Na-permeable kainate receptors", "Activation of Ca-permeable Kainate Receptor"], "P39210": ["Peroxisomal protein import", "Peroxisomal protein import"], "P39656": ["SRP-dependent cotranslational protein targeting to membrane", "Asparagine N-linked glycosylation", "Neutrophil degranulation", "Advanced glycosylation endproduct receptor signaling"], "P39687": ["HuR (ELAVL1) binds and stabilizes mRNA"], "P39748": ["POLB-Dependent Long Patch Base Excision Repair", "Early Phase of HIV Life Cycle", "Removal of the Flap Intermediate from the C-strand", "PCNA-Dependent Long Patch Base Excision Repair", "HDR through MMEJ (alt-NHEJ)", "Removal of the Flap Intermediate"], "P39877": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PS", "Acyl chain remodelling of PE", "Acyl chain remodelling of PI", "Acyl chain remodelling of PG", "Synthesis of PA"], "P39880": ["Signaling by cytosolic FGFR1 fusion mutants", "Signaling by FGFR1 in disease"], "P39900": ["Collagen degradation", "Degradation of the extracellular matrix", "Degradation of the extracellular matrix"], "P39905": ["NCAM1 interactions", "RAF/MAP kinase cascade", "RET signaling"], "P40123": ["Role of ABL in ROBO-SLIT signaling"], "P40126": ["Melanin biosynthesis"], "P40136": ["Uptake and function of anthrax toxins"], "P40145": ["Glucagon signaling in metabolic regulation", "PKA activation", "PKA activation in glucagon signalling", "Adenylate cyclase activating pathway", "Adenylate cyclase inhibitory pathway", "Adenylate cyclase inhibitory pathway", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "G alpha (s) signalling events", "G alpha (s) signalling events", "G alpha (i) signalling events", "G alpha (z) signalling events", "G alpha (z) signalling events", "Vasopressin regulates renal water homeostasis via Aquaporins", "CREB1 phosphorylation through the activation of Adenylate Cyclase", "Hedgehog 'off' state"], "P40189": ["Interleukin-6 signaling", "Interleukin-6 signaling", "IL-6-type cytokine receptor ligand interactions", "Interleukin-35 Signalling", "Interleukin-27 signaling", "Interleukin-27 signaling"], "P40189-1": ["Interleukin-6 signaling", "MAPK3 (ERK1) activation", "MAPK1 (ERK2) activation"], "P40189-2": ["Interleukin-6 signaling"], "P40197": ["Intrinsic Pathway of Fibrin Clot Formation", "GP1b-IX-V activation signalling", "Platelet Adhesion to exposed collagen", "Platelet Aggregation (Plug Formation)"], "P40198": ["Cell surface interactions at the vascular wall", "Neutrophil degranulation"], "P40199": ["Fibronectin matrix formation", "Cell surface interactions at the vascular wall", "Neutrophil degranulation"], "P40200": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "P40222": ["Other interleukin signaling"], "P40225": ["Platelet Aggregation (Plug Formation)"], "P40227": ["Prefoldin mediated transfer of substrate to CCT/TriC", "Formation of tubulin folding intermediates by CCT/TriC", "Folding of actin by CCT/TriC", "Association of TriC/CCT with target proteins during biosynthesis", "Association of TriC/CCT with target proteins during biosynthesis", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "P40238": ["Platelet Aggregation (Plug Formation)"], "P40259": ["CD22 mediated BCR regulation", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P40261": ["Methylation", "Nicotinamide salvaging", "Metabolism of ingested SeMet, Sec, MeSec into H2Se"], "P40305": ["Interferon alpha/beta signaling"], "P40306": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "P40337": ["Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "SUMOylation of ubiquitinylation proteins", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "P40394": ["Ethanol oxidation"], "P40424": ["Transcriptional regulation of pluripotent stem cells", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "NOTCH3 Intracellular Domain Regulates Transcription"], "P40429": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P40616": ["Retrograde transport at the Trans-Golgi-Network"], "P40692": ["Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "Defective Mismatch Repair Associated With MLH1", "Defective Mismatch Repair Associated With PMS2", "TP53 Regulates Transcription of DNA Repair Genes", "Meiotic recombination"], "P40763": ["Interleukin-6 signaling", "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "Interleukin-7 signaling", "Interleukin-7 signaling", "Signaling by SCF-KIT", "Signaling by cytosolic FGFR1 fusion mutants", "Downstream signal transduction", "Signalling to STAT3", "Senescence-Associated Secretory Phenotype (SASP)", "Signaling by Leptin", "POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation", "Association of TriC/CCT with target proteins during biosynthesis", "Transcriptional regulation of pluripotent stem cells", "Interleukin-10 signaling", "Interleukin-4 and Interleukin-13 signaling", "PTK6 Activates STAT3", "PTK6 Activates STAT3", "Interleukin-20 family signaling", "MET activates STAT3", "MET activates STAT3", "Interleukin-15 signaling", "Interleukin-35 Signalling", "Interleukin-9 signaling", "Interleukin-37 signaling", "Interleukin-23 signaling", "Interleukin-23 signaling", "Interleukin-27 signaling", "Interleukin-21 signaling", "Growth hormone receptor signaling"], "P40818": ["Downregulation of ERBB2:ERBB3 signaling", "Regulation of FZD by ubiquitination", "Ub-specific processing proteases", "Negative regulation of MET activity"], "P40855": ["ABC transporters in lipid homeostasis"], "P40879": ["Multifunctional anion exchangers", "Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1)"], "P40925": ["Gluconeogenesis"], "P40926": ["Gluconeogenesis", "Citric acid cycle (TCA cycle)"], "P40933": ["Interleukin-15 signaling", "Interleukin-15 signaling"], "P40937": ["Translesion synthesis by REV1", "Recognition of DNA damage by PCNA-containing replication complex", "Translesion Synthesis by POLH", "Polymerase switching on the C-strand of the telomere", "Activation of ATR in response to replication stress", "PCNA-Dependent Long Patch Base Excision Repair", "Translesion synthesis by POLK", "Translesion synthesis by POLI", "Termination of translesion DNA synthesis", "HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Regulation of TP53 Activity through Phosphorylation", "Polymerase switching", "G2/M DNA damage checkpoint"], "P40938": ["Translesion synthesis by REV1", "Recognition of DNA damage by PCNA-containing replication complex", "Translesion Synthesis by POLH", "Polymerase switching on the C-strand of the telomere", "Activation of ATR in response to replication stress", "PCNA-Dependent Long Patch Base Excision Repair", "Translesion synthesis by POLK", "Translesion synthesis by POLI", "Termination of translesion DNA synthesis", "HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Regulation of TP53 Activity through Phosphorylation", "Polymerase switching", "G2/M DNA damage checkpoint"], "P40939": ["Acyl chain remodeling of CL", "Beta oxidation of myristoyl-CoA to lauroyl-CoA", "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids", "Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "Beta oxidation of hexanoyl-CoA to butanoyl-CoA"], "P41002": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "P41091": ["L13a-mediated translational silencing of Ceruloplasmin expression", "ABC-family proteins mediated transport", "Translation initiation complex formation", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Recycling of eIF2:GDP"], "P41134": ["Oncogene Induced Senescence"], "P41143": ["Peptide ligand-binding receptors", "G alpha (i) signalling events", "Interleukin-4 and Interleukin-13 signaling"], "P41145": ["Peptide ligand-binding receptors", "G alpha (i) signalling events", "MECP2 regulates neuronal receptors and channels"], "P41146": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "P41159": ["Signaling by Leptin", "Transcriptional regulation of white adipocyte differentiation", "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "Synthesis, secretion, and deacylation of Ghrelin"], "P41180": ["G alpha (q) signalling events", "G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "P41181": ["Vasopressin regulates renal water homeostasis via Aquaporins", "Passive transport by Aquaporins"], "P41182": ["Interleukin-4 and Interleukin-13 signaling", "TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "FOXO-mediated transcription of cell death genes"], "P41208": ["Regulation of PLK1 Activity at G2/M Transition", "SUMOylation of DNA damage response and repair proteins", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "DNA Damage Recognition in GG-NER", "Formation of Incision Complex in GG-NER", "AURKA Activation by TPX2"], "P41217": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "P41218": ["Neutrophil degranulation"], "P41220": ["G alpha (q) signalling events"], "P41221": ["TCF dependent signaling in response to WNT", "TCF dependent signaling in response to WNT", "WNT ligand biogenesis and trafficking", "WNT ligand biogenesis and trafficking", "Class B/2 (Secretin family receptors)", "Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "Ca2+ pathway", "Ca2+ pathway", "PCP/CE pathway", "PCP/CE pathway", "Asymmetric localization of PCP proteins", "WNT5A-dependent internalization of FZD4", "WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "P41222": ["Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"], "P41223": ["mRNA Splicing - Major Pathway"], "P41225": ["Deactivation of the beta-catenin transactivating complex"], "P41226": ["ISG15 antiviral mechanism", "DDX58/IFIH1-mediated induction of interferon-alpha/beta", "Termination of translesion DNA synthesis", "Negative regulators of DDX58/IFIH1 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "P41229": ["HDMs demethylate histones"], "P41231": ["G alpha (q) signalling events", "P2Y receptors", "Surfactant metabolism"], "P41235": ["Nuclear Receptor transcription pathway"], "P41235-5": ["Regulation of gene expression in beta cells"], "P41235-6": ["Regulation of gene expression in beta cells"], "P41235-7": ["Regulation of gene expression in beta cells"], "P41238": ["mRNA Editing: C to U Conversion", "Formation of the Editosome"], "P41240": ["GAB1 signalosome", "Phosphorylation of CD3 and TCR zeta chains", "Integrin alphaIIb beta3 signaling", "PD-1 signaling", "MAP2K and MAPK activation", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF"], "P41247": ["Triglyceride catabolism"], "P41250": ["Cytosolic tRNA aminoacylation", "Mitochondrial tRNA aminoacylation"], "P41252": ["SeMet incorporation into proteins", "Cytosolic tRNA aminoacylation"], "P41273": ["TNFs bind their physiological receptors"], "P41279": ["CD28 dependent PI3K/Akt signaling", "MAP3K8 (TPL2)-dependent MAPK1/3 activation", "MAP3K8 (TPL2)-dependent MAPK1/3 activation"], "P41439": ["Neutrophil degranulation"], "P41440": ["Metabolism of folate and pterines"], "P41586": ["NGF-independant TRKA activation", "G alpha (s) signalling events", "Glucagon-type ligand receptors"], "P41587": ["G alpha (s) signalling events", "Glucagon-type ligand receptors"], "P41594": ["G alpha (q) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)", "Neurexins and neuroligins", "Neurexins and neuroligins"], "P41595": ["Serotonin receptors", "G alpha (q) signalling events"], "P41597": ["Beta defensins", "Chemokine receptors bind chemokines", "G alpha (i) signalling events", "Interleukin-10 signaling"], "P41732": ["Cell surface interactions at the vascular wall", "Trafficking of GluR2-containing AMPA receptors"], "P41743": ["Pre-NOTCH Transcription and Translation", "p75NTR recruits signalling complexes", "Tight junction interactions"], "P41785": ["The IPAF inflammasome", "The IPAF inflammasome"], "P41797": ["Antimicrobial peptides"], "P41968": ["Peptide ligand-binding receptors", "G alpha (s) signalling events"], "P42025": ["MHC class II antigen presentation", "Neutrophil degranulation"], "P42081": ["PIP3 activates AKT signaling", "Constitutive Signaling by Aberrant PI3K in Cancer", "CD28 co-stimulation", "CD28 dependent PI3K/Akt signaling", "CD28 dependent Vav1 pathway", "CTLA4 inhibitory signaling", "Interleukin-10 signaling", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "P42126": ["mitochondrial fatty acid beta-oxidation of unsaturated fatty acids"], "P42167-1": ["Clearance of Nuclear Envelope Membranes from Chromatin", "Initiation of Nuclear Envelope Reformation", "Depolymerisation of the Nuclear Lamina"], "P42224": ["Interleukin-6 signaling", "ISG15 antiviral mechanism", "Signaling by SCF-KIT", "Signaling by cytosolic FGFR1 fusion mutants", "Downstream signal transduction", "Interleukin-4 and Interleukin-13 signaling", "Interleukin-20 family signaling", "Regulation of RUNX2 expression and activity", "Interleukin-35 Signalling", "Interleukin-9 signaling", "NOTCH3 Intracellular Domain Regulates Transcription", "NOTCH3 Intracellular Domain Regulates Transcription", "Interleukin-27 signaling", "Interleukin-21 signaling", "Growth hormone receptor signaling"], "P42224-1": ["Interleukin-6 signaling", "Signaling by SCF-KIT", "Interferon gamma signaling", "Regulation of IFNG signaling", "Interferon alpha/beta signaling", "Regulation of IFNA signaling"], "P42224-2": ["Interferon alpha/beta signaling", "Regulation of IFNA signaling"], "P42226": ["Downstream signal transduction", "STAT6-mediated induction of chemokines", "Interleukin-4 and Interleukin-13 signaling"], "P42229": ["Prolactin receptor signaling", "Nuclear signaling by ERBB4", "Interleukin-7 signaling", "Interleukin-7 signaling", "Signaling by SCF-KIT", "Signaling by cytosolic FGFR1 fusion mutants", "Downstream signal transduction", "Signaling by Leptin", "Signaling by Leptin", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "Interleukin-20 family signaling", "Interleukin-15 signaling", "Interleukin-9 signaling", "Interleukin-2 signaling", "Interleukin-2 signaling", "Interleukin-21 signaling", "Erythropoietin activates STAT5", "Growth hormone receptor signaling", "Growth hormone receptor signaling"], "P42261": ["COPII-mediated vesicle transport", "Activation of AMPA receptors", "Trafficking of AMPA receptors", "Trafficking of GluR2-containing AMPA receptors", "Unblocking of NMDA receptors, glutamate binding and activation", "Unblocking of NMDA receptors, glutamate binding and activation", "Cargo concentration in the ER", "Synaptic adhesion-like molecules", "Long-term potentiation"], "P42262": ["Activation of AMPA receptors", "Trafficking of GluR2-containing AMPA receptors", "Unblocking of NMDA receptors, glutamate binding and activation", "Unblocking of NMDA receptors, glutamate binding and activation", "MECP2 regulates neuronal receptors and channels", "Long-term potentiation"], "P42263": ["Activation of AMPA receptors", "Trafficking of AMPA receptors", "Trafficking of GluR2-containing AMPA receptors", "Unblocking of NMDA receptors, glutamate binding and activation", "Unblocking of NMDA receptors, glutamate binding and activation", "Synaptic adhesion-like molecules"], "P42285": ["Major pathway of rRNA processing in the nucleolus and cytosol", "mRNA Splicing - Major Pathway"], "P42330": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of bile acids and bile salts via 24-hydroxycholesterol", "Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "RA biosynthesis pathway", "Retinoid metabolism and transport"], "P42331": ["Rho GTPase cycle"], "P42336": ["PI3K Cascade", "IRS-mediated signalling", "GPVI-mediated activation cascade", "Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "PI3K events in ERBB4 signaling", "PIP3 activates AKT signaling", "Signaling by SCF-KIT", "Synthesis of PIPs at the plasma membrane", "GAB1 signalosome", "Signaling by cytosolic FGFR1 fusion mutants", "Downstream signal transduction", "PI3K events in ERBB2 signaling", "PI3K/AKT activation", "Downstream TCR signaling", "Role of phospholipids in phagocytosis", "Tie2 Signaling", "Constitutive Signaling by Aberrant PI3K in Cancer", "DAP12 signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Nephrin family interactions", "Costimulation by the CD28 family", "CD28 dependent PI3K/Akt signaling", "G alpha (q) signalling events", "VEGFA-VEGFR2 Pathway", "VEGFA-VEGFR2 Pathway", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "Constitutive Signaling by EGFRvIII", "PI-3K cascade:FGFR1", "PI-3K cascade:FGFR2", "PI-3K cascade:FGFR3", "PI-3K cascade:FGFR4", "Signaling by FGFR2 in disease", "Signaling by FGFR4 in disease", "Signaling by FGFR1 in disease", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "MET activates PI3K/AKT signaling", "Signaling by FGFR3 fusions in cancer", "Signaling by FGFR3 point mutants in cancer", "RET signaling", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "Activated NTRK2 signals through PI3K", "Interleukin receptor SHC signaling", "Regulation of signaling by CBL", "Regulation of signaling by CBL", "Activated NTRK3 signals through PI3K"], "P42338": ["PI3K Cascade", "IRS-mediated signalling", "GPVI-mediated activation cascade", "PIP3 activates AKT signaling", "Synthesis of PIPs at the plasma membrane", "Downstream signal transduction", "PI3K/AKT activation", "Downstream TCR signaling", "Role of phospholipids in phagocytosis", "Tie2 Signaling", "Constitutive Signaling by Aberrant PI3K in Cancer", "DAP12 signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Nephrin family interactions", "VEGFA-VEGFR2 Pathway", "VEGFA-VEGFR2 Pathway", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "RET signaling", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "Interleukin receptor SHC signaling", "Regulation of signaling by CBL", "Regulation of signaling by CBL"], "P42345": ["PIP3 activates AKT signaling", "Macroautophagy", "mTOR signalling", "mTORC1-mediated signalling", "HSF1-dependent transactivation", "Energy dependent regulation of mTOR by LKB1-AMPK", "CD28 dependent PI3K/Akt signaling", "VEGFR2 mediated vascular permeability", "TP53 Regulates Metabolic Genes", "Constitutive Signaling by AKT1 E17K in Cancer", "Regulation of TP53 Degradation", "Regulation of PTEN gene transcription"], "P42356": ["Synthesis of PIPs at the ER membrane", "Synthesis of PIPs at the Golgi membrane"], "P42357": ["Histidine catabolism"], "P42566": ["EGFR downregulation", "Negative regulation of MET activity", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "InlB-mediated entry of Listeria monocytogenes into host cell"], "P42568": ["Formation of RNA Pol II elongation complex ", "RNA Polymerase II Pre-transcription Events", "RNA Polymerase II Transcription Elongation"], "P42574": ["Activation of caspases through apoptosome-mediated cleavage", "SMAC (DIABLO) binds to IAPs ", "SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ", "Apoptotic cleavage of cellular proteins", "SMAC, XIAP-regulated apoptotic response", "Degradation of the extracellular matrix", "Signaling by Hippo", "NADE modulates death signalling", "Activation of DNA fragmentation factor", "Stimulation of the cell death response by PAK-2p34", "Caspase-mediated cleavage of cytoskeletal proteins", "Apoptotic cleavage of cell adhesion proteins", "Caspase activation via Dependence Receptors in the absence of ligand", "Caspase activation via Dependence Receptors in the absence of ligand", "Other interleukin signaling"], "P42575": ["NOD1/2 Signaling Pathway", "NADE modulates death signalling", "TP53 Regulates Transcription of Caspase Activators and Caspases"], "P42677": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Major pathway of rRNA processing in the nucleolus and cytosol", "Mitotic Prometaphase", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P42679": ["Downregulation of ERBB2 signaling"], "P42680": ["Signaling by SCF-KIT", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "Interleukin-3, Interleukin-5 and GM-CSF signaling"], "P42681": ["FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization"], "P42684": ["Role of ABL in ROBO-SLIT signaling", "Role of ABL in ROBO-SLIT signaling"], "P42685": ["Neutrophil degranulation", "Regulation of PTEN stability and activity"], "P42695": ["Condensation of Prophase Chromosomes"], "P42701": ["Interleukin-12 signaling", "Interleukin-12 signaling", "Interleukin-23 signaling", "Interleukin-23 signaling"], "P42702": ["IL-6-type cytokine receptor ligand interactions", "RUNX1 regulates transcription of genes involved in interleukin signaling"], "P42704": ["TP53 Regulates Metabolic Genes", "Respiratory electron transport"], "P42765": ["Mitochondrial Fatty Acid Beta-Oxidation"], "P42766": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P42768": ["Generation of second messenger molecules", "Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs"], "P42771": ["Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "Oncogene Induced Senescence", "Cyclin D associated events in G1"], "P42772": ["SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "Oncogene Induced Senescence", "Cyclin D associated events in G1"], "P42773": ["Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "Oncogene Induced Senescence", "Cyclin D associated events in G1"], "P42785": ["Intrinsic Pathway of Fibrin Clot Formation", "Neutrophil degranulation"], "P42830": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "P42858": ["Regulation of MECP2 expression and activity"], "P42892": ["Peptide ligand-binding receptors"], "P42898": ["Metabolism of folate and pterines"], "P43003": ["Astrocytic Glutamate-Glutamine Uptake And Metabolism", "Glutamate Neurotransmitter Release Cycle", "Transport of inorganic cations/anions and amino acids/oligopeptides", "Defective SLC1A3 causes episodic ataxia 6 (EA6)"], "P43004": ["Astrocytic Glutamate-Glutamine Uptake And Metabolism", "Glutamate Neurotransmitter Release Cycle", "Transport of inorganic cations/anions and amino acids/oligopeptides"], "P43005": ["Glutamate Neurotransmitter Release Cycle", "Transport of inorganic cations/anions and amino acids/oligopeptides", "Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA)"], "P43007": ["Amino acid transport across the plasma membrane"], "P43026": ["Molecules associated with elastic fibres"], "P43034": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "RHO GTPases Activate Formins", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "AURKA Activation by TPX2"], "P43080": ["Inactivation, recovery and regulation of the phototransduction cascade"], "P43088": ["Prostanoid ligand receptors", "G alpha (q) signalling events"], "P43115": ["Prostanoid ligand receptors", "G alpha (i) signalling events"], "P43116": ["Prostanoid ligand receptors", "G alpha (s) signalling events"], "P43119": ["Prostanoid ligand receptors", "Prostacyclin signalling through prostacyclin receptor", "Prostacyclin signalling through prostacyclin receptor", "G alpha (s) signalling events"], "P43146": ["Netrin-1 signaling", "Netrin-1 signaling", "DSCAM interactions", "DCC mediated attractive signaling", "DCC mediated attractive signaling", "Netrin mediated repulsion signals", "Caspase activation via Dependence Receptors in the absence of ligand", "Role of second messengers in netrin-1 signaling", "Regulation of commissural axon pathfinding by SLIT and ROBO"], "P43155": ["Beta-oxidation of pristanoyl-CoA", "Peroxisomal protein import", "Peroxisomal protein import"], "P43166": ["Reversible hydration of carbon dioxide"], "P43220": ["Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "G alpha (s) signalling events", "Glucagon-type ligand receptors"], "P43234": ["MHC class II antigen presentation"], "P43235": ["Collagen degradation", "Degradation of the extracellular matrix", "Activation of Matrix Metalloproteinases", "Trafficking and processing of endosomal TLR", "MHC class II antigen presentation", "RUNX1 regulates transcription of genes involved in differentiation of keratinocytes"], "P43246": ["Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "Defective Mismatch Repair Associated With MSH3", "Defective Mismatch Repair Associated With MSH2", "Defective Mismatch Repair Associated With MSH6", "TP53 Regulates Transcription of DNA Repair Genes"], "P43250": ["G alpha (s) signalling events"], "P43251": ["Biotin transport and metabolism", "Defective BTD causes biotidinase deficiency"], "P43268": ["MAPK6/MAPK4 signaling"], "P43304": ["Synthesis of PA", "Triglyceride catabolism"], "P43307": ["SRP-dependent cotranslational protein targeting to membrane", "XBP1(S) activates chaperone genes"], "P43308": ["SRP-dependent cotranslational protein targeting to membrane"], "P43351": ["SUMOylation of DNA damage response and repair proteins", "HDR through Single Strand Annealing (SSA)"], "P43353": ["Sphingolipid de novo biosynthesis", "Neutrophil degranulation"], "P43354": ["Nuclear Receptor transcription pathway", "SUMOylation of intracellular receptors"], "P43378": ["Interleukin-37 signaling"], "P43403": ["Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules"], "P43405": ["GPVI-mediated activation cascade", "GPVI-mediated activation cascade", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "DAP12 signaling", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "Integrin alphaIIb beta3 signaling", "CLEC7A (Dectin-1) signaling", "Dectin-2 family", "Dectin-2 family", "Interleukin-2 signaling", "Regulation of signaling by CBL", "Regulation of signaling by CBL", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P43487": ["Rev-mediated nuclear export of HIV RNA"], "P43489": ["TNFs bind their physiological receptors"], "P43490": ["BMAL1:CLOCK,NPAS2 activates circadian gene expression", "Nicotinamide salvaging"], "P43626": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "P43627": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "P43628": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "P43629": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "P43630": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "P43631": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "DAP12 interactions"], "P43632": ["DAP12 interactions"], "P43657": ["G alpha (q) signalling events", "P2Y receptors"], "P43681": ["Highly sodium permeable acetylcholine nicotinic receptors", "Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "Highly calcium permeable nicotinic acetylcholine receptors"], "P43686": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "P43694": ["YAP1- and WWTR1 (TAZ)-stimulated gene expression", "Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)", "Physiological factors", "Factors involved in megakaryocyte development and platelet production"], "P43897": ["Mitochondrial translation elongation"], "P45378": ["Striated Muscle Contraction"], "P45379": ["Striated Muscle Contraction"], "P45381": ["Amino acid synthesis and interconversion (transamination)"], "P45452": ["Collagen degradation", "Collagen degradation", "Degradation of the extracellular matrix", "Degradation of the extracellular matrix", "Activation of Matrix Metalloproteinases", "Assembly of collagen fibrils and other multimeric structures", "RUNX2 regulates genes involved in cell migration"], "P45844": ["ABC transporters in lipid homeostasis", "HDL remodeling"], "P45880": ["Ub-specific processing proteases", "Mitochondrial calcium ion transport"], "P45954": ["Branched-chain amino acid catabolism"], "P45973": ["SUMOylation of chromatin organization proteins", "Transcriptional Regulation by E2F6", "Factors involved in megakaryocyte development and platelet production"], "P45974": ["Ub-specific processing proteases", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes"], "P45983": ["Activation of BIM and translocation to mitochondria ", "Activation of BMF and translocation to mitochondria", "NRAGE signals death through JNK", "NRAGE signals death through JNK", "NRIF signals cell death from the nucleus", "Oxidative Stress Induced Senescence", "FCERI mediated MAPK activation", "DSCAM interactions", "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "Activation of the AP-1 family of transcription factors", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Interleukin-38 signaling"], "P45984": ["Oxidative Stress Induced Senescence", "FCERI mediated MAPK activation", "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "Activation of the AP-1 family of transcription factors"], "P45985": ["Oxidative Stress Induced Senescence", "Oxidative Stress Induced Senescence", "FCERI mediated MAPK activation", "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "Uptake and function of anthrax toxins", "MAP3K8 (TPL2)-dependent MAPK1/3 activation"], "P46019": ["Glycogen breakdown (glycogenolysis)"], "P46020": ["Glycogen breakdown (glycogenolysis)", "Glycogen breakdown (glycogenolysis)"], "P46059": ["Proton/oligopeptide cotransporters"], "P46060": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Rev-mediated nuclear export of HIV RNA", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA replication proteins", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "P46087": ["rRNA modification in the nucleus and cytosol", "TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation"], "P46092": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "P46093": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (q) signalling events"], "P46094": ["Chemokine receptors bind chemokines", "G alpha (q) signalling events"], "P46098": ["Neurotransmitter receptors and postsynaptic signal transmission"], "P46108": ["ARMS-mediated activation", "ARMS-mediated activation", "Downstream signal transduction", "Regulation of actin dynamics for phagocytic cup formation", "p130Cas linkage to MAPK signaling for integrins", "VEGFA-VEGFR2 Pathway", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "MET activates RAP1 and RAC1", "MET receptor recycling", "Regulation of signaling by CBL"], "P46109": ["Frs2-mediated activation", "Frs2-mediated activation", "Downstream signal transduction", "MET activates RAP1 and RAC1", "MET receptor recycling", "Erythropoietin activates RAS", "Erythropoietin activates RAS", "Regulation of signaling by CBL"], "P46199": ["Mitochondrial translation initiation"], "P46439": ["Glutathione conjugation"], "P46459": ["COPII-mediated vesicle transport", "Trafficking of GluR2-containing AMPA receptors", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network"], "P46527": ["SCF(Skp2)-mediated degradation of p27/p21", "AKT phosphorylates targets in the cytosol", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "RHO GTPases activate CIT", "Constitutive Signaling by AKT1 E17K in Cancer", "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "Cyclin E associated events during G1/S transition ", "Cyclin D associated events in G1", "p53-Dependent G1 DNA Damage Response", "Cyclin A:Cdk2-associated events at S phase entry", "PTK6 Regulates Cell Cycle", "FOXO-mediated transcription of cell cycle genes"], "P46531": ["Pre-NOTCH Processing in the Endoplasmic Reticulum", "Pre-NOTCH Transcription and Translation", "Pre-NOTCH Transcription and Translation", "Pre-NOTCH Processing in Golgi", "Pre-NOTCH Processing in Golgi", "Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "NOTCH1 Intracellular Domain Regulates Transcription", "NOTCH1 Intracellular Domain Regulates Transcription", "Activated NOTCH1 Transmits Signal to the Nucleus", "Activated NOTCH1 Transmits Signal to the Nucleus", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling", "Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant", "Constitutive Signaling by NOTCH1 HD Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "Notch-HLH transcription pathway", "Defective LFNG causes SCDO3", "RUNX3 regulates NOTCH signaling", "RUNX3 regulates NOTCH signaling", "NOTCH3 Intracellular Domain Regulates Transcription", "NOTCH3 Intracellular Domain Regulates Transcription", "NOTCH4 Intracellular Domain Regulates Transcription"], "P46587": ["Antimicrobial peptides"], "P46597": ["Serotonin and melatonin biosynthesis"], "P46663": ["Peptide ligand-binding receptors", "G alpha (q) signalling events", "G alpha (i) signalling events"], "P46695": ["PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "P46721": ["Recycling of bile acids and salts", "Transport of organic anions"], "P46734": ["Oxidative Stress Induced Senescence", "activated TAK1 mediates p38 MAPK activation"], "P46734-3": ["Uptake and function of anthrax toxins"], "P46736": ["Metalloprotease DUBs", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "G2/M DNA damage checkpoint"], "P46776": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P46777": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P46778": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P46779": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P46781": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P46782": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P46783": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P46926": ["Glycolysis"], "P46934": ["ISG15 antiviral mechanism", "Downregulation of ERBB4 signaling", "Regulation of PTEN localization", "Regulation of PTEN stability and activity", "Antigen processing: Ubiquitination & Proteasome degradation"], "P46937": ["Nuclear signaling by ERBB4", "Signaling by Hippo", "YAP1- and WWTR1 (TAZ)-stimulated gene expression", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "RUNX2 regulates osteoblast differentiation", "RUNX3 regulates YAP1-mediated transcription"], "P46940": ["Nephrin family interactions", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "RHO GTPases activate IQGAPs", "MAP2K and MAPK activation", "Neutrophil degranulation", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF"], "P46952": ["Tryptophan catabolism"], "P46976": ["Glycogen synthesis", "Myoclonic epilepsy of Lafora", "Glycogen storage disease type XV (GYG1)", "Glycogen storage disease type 0 (muscle GYS1)", "Glycogen storage disease type II (GAA)", "Neutrophil degranulation", "Glycogen breakdown (glycogenolysis)", "Glycogen breakdown (glycogenolysis)"], "P46977": ["Asparagine N-linked glycosylation"], "P47211": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "P47710": ["Miscellaneous transport and binding events"], "P47712": ["phospho-PLA2 pathway", "Acyl chain remodelling of PC", "Acyl chain remodeling of CL", "Acyl chain remodelling of PS", "Acyl chain remodelling of PE", "Acyl chain remodelling of PI", "Acyl chain remodelling of PG", "Hydrolysis of LPC", "Synthesis of PA", "Arachidonic acid metabolism", "ADP signalling through P2Y purinoceptor 1", "Platelet sensitization by LDL", "COPI-independent Golgi-to-ER retrograde traffic"], "P47736": ["Rap1 signalling", "RET signaling"], "P47755": ["MHC class II antigen presentation", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic", "Advanced glycosylation endproduct receptor signaling", "Factors involved in megakaryocyte development and platelet production", "Factors involved in megakaryocyte development and platelet production"], "P47756": ["MHC class II antigen presentation", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic", "Factors involved in megakaryocyte development and platelet production", "Factors involved in megakaryocyte development and platelet production"], "P47804": ["G alpha (i) signalling events", "Opsins"], "P47813": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "P47869": ["GABA A receptor activation", "GABA receptor activation"], "P47870": ["GABA A receptor activation", "GABA receptor activation"], "P47871": ["Glucagon signaling in metabolic regulation", "G alpha (q) signalling events", "G alpha (s) signalling events", "Glucagon-type ligand receptors"], "P47872": ["G alpha (s) signalling events", "Glucagon-type ligand receptors"], "P47881": ["Olfactory Signaling Pathway"], "P47883": ["Olfactory Signaling Pathway"], "P47884": ["Olfactory Signaling Pathway"], "P47887": ["Olfactory Signaling Pathway"], "P47888": ["Olfactory Signaling Pathway"], "P47890": ["Olfactory Signaling Pathway"], "P47893": ["Olfactory Signaling Pathway"], "P47895": ["RA biosynthesis pathway"], "P47897": ["SeMet incorporation into proteins", "Cytosolic tRNA aminoacylation", "Mitochondrial tRNA aminoacylation"], "P47898": ["Serotonin receptors", "G alpha (i) signalling events"], "P47900": ["G alpha (q) signalling events", "P2Y receptors", "ADP signalling through P2Y purinoceptor 1", "ADP signalling through P2Y purinoceptor 1"], "P47901": ["Vasopressin-like receptors", "G alpha (q) signalling events", "Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI)"], "P47914": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P47944": ["Metallothioneins bind metals"], "P47985": ["Respiratory electron transport"], "P47989": ["Purine catabolism", "Butyrophilin (BTN) family interactions"], "P47992": ["Chemokine receptors bind chemokines", "G alpha (q) signalling events"], "P48023": ["Caspase activation via Death Receptors in the presence of ligand", "Regulation by c-FLIP", "RIPK1-mediated regulated necrosis", "CASP8 activity is inhibited", "Interleukin-4 and Interleukin-13 signaling", "Dimerization of procaspase-8", "FasL/ CD95L signaling", "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "FOXO-mediated transcription of cell death genes"], "P48029": ["Creatine metabolism"], "P48039": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (i) signalling events"], "P48047": ["Formation of ATP by chemiosmotic coupling", "Cristae formation"], "P48048": ["Potassium transport channels"], "P48050": ["Activation of G protein gated Potassium channels", "Classical Kir channels", "Phase 4 - resting membrane potential", "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "P48051": ["Activation of G protein gated Potassium channels", "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "P48058": ["Activation of AMPA receptors", "Trafficking of AMPA receptors", "Trafficking of GluR2-containing AMPA receptors", "Unblocking of NMDA receptors, glutamate binding and activation", "Unblocking of NMDA receptors, glutamate binding and activation", "Synaptic adhesion-like molecules"], "P48059": ["Cell-extracellular matrix interactions", "Regulation of cytoskeletal remodeling and cell spreading by IPP complex components"], "P48060": ["PPARA activates gene expression", "Neutrophil degranulation"], "P48061": ["Nuclear signaling by ERBB4", "Signaling by ROBO receptors", "Chemokine receptors bind chemokines", "G alpha (i) signalling events", "Estrogen-dependent gene expression"], "P48065": ["Amino acid transport across the plasma membrane", "Na+/Cl- dependent neurotransmitter transporters", "Creatine metabolism", "Reuptake of GABA"], "P48066": ["Na+/Cl- dependent neurotransmitter transporters", "Creatine metabolism", "Reuptake of GABA"], "P48067": ["Na+/Cl- dependent neurotransmitter transporters"], "P48145": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "P48146": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "P48163": ["PPARA activates gene expression", "Pyruvate metabolism"], "P48165": ["Gap junction assembly"], "P48167": ["Neurotransmitter receptors and postsynaptic signal transmission"], "P48169": ["GABA A receptor activation", "GABA receptor activation"], "P48200": ["Iron uptake and transport"], "P48201": ["Formation of ATP by chemiosmotic coupling", "Cristae formation"], "P48357-1": ["Signaling by Leptin"], "P48426": ["Synthesis of PIPs at the plasma membrane", "PI5P Regulates TP53 Acetylation", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Synthesis of PIPs in the nucleus"], "P48431": ["POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation", "POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation", "Deactivation of the beta-catenin transactivating complex", "Transcriptional regulation of pluripotent stem cells", "Interleukin-4 and Interleukin-13 signaling", "Transcriptional Regulation by MECP2"], "P48436": ["Deactivation of the beta-catenin transactivating complex", "Transcriptional regulation by RUNX2"], "P48443": ["Nuclear Receptor transcription pathway", "Signaling by Retinoic Acid"], "P48444": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "P48448": ["Sphingolipid de novo biosynthesis"], "P48449": ["Cholesterol biosynthesis", "Activation of gene expression by SREBF (SREBP)"], "P48454": ["Activation of BAD and translocation to mitochondria ", "DARPP-32 events"], "P48506": ["Glutathione synthesis and recycling", "Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)"], "P48507": ["Glutathione synthesis and recycling"], "P48509": ["Assembly of collagen fibrils and other multimeric structures", "Type I hemidesmosome assembly"], "P48544": ["Activation of G protein gated Potassium channels", "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "P48546": ["G alpha (s) signalling events", "Glucagon-type ligand receptors"], "P48547": ["Voltage gated Potassium channels"], "P48549": ["Activation of G protein gated Potassium channels", "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "P48551-2": ["Interferon alpha/beta signaling", "Regulation of IFNA signaling", "Regulation of IFNA signaling"], "P48552": ["SUMOylation of transcription cofactors", "Circadian Clock", "Estrogen-dependent gene expression"], "P48553": ["COPII-mediated vesicle transport", "RAB GEFs exchange GTP for GDP on RABs"], "P48556": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "P48595": ["Neutrophil degranulation"], "P48637": ["Glutathione synthesis and recycling", "Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)"], "P48643": ["Prefoldin mediated transfer of substrate to CCT/TriC", "Formation of tubulin folding intermediates by CCT/TriC", "Folding of actin by CCT/TriC", "Association of TriC/CCT with target proteins during biosynthesis", "Association of TriC/CCT with target proteins during biosynthesis", "BBSome-mediated cargo-targeting to cilium", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "P48645": ["Peptide ligand-binding receptors", "G alpha (q) signalling events", "G alpha (i) signalling events"], "P48651": ["Synthesis of PS"], "P48664": ["Glutamate Neurotransmitter Release Cycle", "Transport of inorganic cations/anions and amino acids/oligopeptides"], "P48668": ["Keratinization", "Formation of the cornified envelope"], "P48723": ["Regulation of HSF1-mediated heat shock response"], "P48728": ["Glycine degradation"], "P48729": ["Degradation of beta-catenin by the destruction complex", "Beta-catenin phosphorylation cascade", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Misspliced GSK3beta mutants stabilize beta-catenin", "S33 mutants of beta-catenin aren't phosphorylated", "S37 mutants of beta-catenin aren't phosphorylated", "S45 mutants of beta-catenin aren't phosphorylated", "T41 mutants of beta-catenin aren't phosphorylated", "APC truncation mutants have impaired AXIN binding", "AXIN missense mutants destabilize the destruction complex", "Truncations of AMER1 destabilize the destruction complex", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Activation of SMO", "Activation of SMO"], "P48730": ["COPII-mediated vesicle transport", "Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Circadian Clock", "Anchoring of the basal body to the plasma membrane", "Major pathway of rRNA processing in the nucleolus and cytosol", "AURKA Activation by TPX2"], "P48735": ["Transcriptional activation of mitochondrial biogenesis", "Citric acid cycle (TCA cycle)"], "P48736": ["GPVI-mediated activation cascade", "Synthesis of PIPs at the plasma membrane", "G beta:gamma signalling through PI3Kgamma", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)"], "P48739": ["PI and PC transport between ER and Golgi membranes"], "P48740": ["Lectin pathway of complement activation", "Initial triggering of complement", "Ficolins bind to repetitive carbohydrate structures on the target cell surface", "Scavenging by Class A Receptors"], "P48741": ["Regulation of HSF1-mediated heat shock response"], "P48751": ["Bicarbonate transporters"], "P48764": ["Sodium/Proton exchangers"], "P48775": ["Tryptophan catabolism"], "P48788": ["Striated Muscle Contraction"], "P48960": ["Class B/2 (Secretin family receptors)", "Neutrophil degranulation"], "P48995": ["TRP channels", "Role of second messengers in netrin-1 signaling", "Ion homeostasis", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P49005": ["Recognition of DNA damage by PCNA-containing replication complex", "Polymerase switching on the C-strand of the telomere", "Processive synthesis on the C-strand of the telomere", "Telomere C-strand (Lagging Strand) Synthesis", "Removal of the Flap Intermediate from the C-strand", "Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "PCNA-Dependent Long Patch Base Excision Repair", "Termination of translesion DNA synthesis", "HDR through Homologous Recombination (HRR)", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Polymerase switching", "Removal of the Flap Intermediate", "Processive synthesis on the lagging strand"], "P49019": ["Hydroxycarboxylic acid-binding receptors", "G alpha (i) signalling events"], "P49023": ["GAB1 signalosome", "VEGFA-VEGFR2 Pathway", "Smooth Muscle Contraction", "Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases"], "P49116": ["Nuclear Receptor transcription pathway"], "P49137": ["p38MAPK events", "CREB phosphorylation", "Synthesis of Leukotrienes (LT) and Eoxins (EX)", "Oxidative Stress Induced Senescence", "Regulation of HSF1-mediated heat shock response", "VEGFA-VEGFR2 Pathway", "activated TAK1 mediates p38 MAPK activation", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA"], "P49146": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "P49184": ["Neutrophil degranulation"], "P49189": ["Carnitine synthesis"], "P49190": ["Class B/2 (Secretin family receptors)", "G alpha (s) signalling events"], "P49207": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P49238": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "P49247": ["RPIA deficiency: failed conversion of R5P to RU5P", "RPIA deficiency: failed conversion of RU5P to R5P", "Pentose phosphate pathway"], "P49257": ["COPII-mediated vesicle transport", "Cargo concentration in the ER", "Transport to the Golgi and subsequent modification"], "P49279": ["ROS, RNS production in phagocytes", "Metal ion SLC transporters", "Neutrophil degranulation", "Ion influx/efflux at host-pathogen interface"], "P49281": ["Metal ion SLC transporters", "Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1)", "Iron uptake and transport"], "P49286": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (i) signalling events"], "P49327": ["ChREBP activates metabolic gene expression", "Vitamin B5 (pantothenate) metabolism", "Activation of gene expression by SREBF (SREBP)", "Fatty acyl-CoA biosynthesis", "Fatty acyl-CoA biosynthesis"], "P49336": ["PPARA activates gene expression", "NOTCH1 Intracellular Domain Regulates Transcription", "Generic Transcription Pathway", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "P49354": ["Apoptotic cleavage of cellular proteins", "Inactivation, recovery and regulation of the phototransduction cascade"], "P49356": ["Inactivation, recovery and regulation of the phototransduction cascade"], "P49366": ["Hypusine synthesis from eIF5A-lysine"], "P49368": ["Prefoldin mediated transfer of substrate to CCT/TriC", "Formation of tubulin folding intermediates by CCT/TriC", "Folding of actin by CCT/TriC", "Association of TriC/CCT with target proteins during biosynthesis", "Association of TriC/CCT with target proteins during biosynthesis", "BBSome-mediated cargo-targeting to cilium", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "P49406": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "P49407": ["Activated NOTCH1 Transmits Signal to the Nucleus", "G alpha (s) signalling events", "Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis", "Thrombin signalling through proteinase activated receptors (PARs)", "Activation of SMO", "Activation of SMO", "MAP2K and MAPK activation", "Ub-specific processing proteases", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "P49411": ["Mitochondrial translation elongation"], "P49418": ["Clathrin-mediated endocytosis"], "P49419": ["Choline catabolism", "Lysine catabolism"], "P49427": ["Downstream TCR signaling", "FCERI mediated NF-kB activation", "CLEC7A (Dectin-1) signaling", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Antigen processing: Ubiquitination & Proteasome degradation"], "P49441": ["Synthesis of IP2, IP, and Ins in the cytosol"], "P49448": ["Transcriptional activation of mitochondrial biogenesis", "Amino acid synthesis and interconversion (transamination)"], "P49450": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Deposition of new CENPA-containing nucleosomes at the centromere", "Mitotic Prometaphase"], "P49454": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Polo-like kinase mediated events", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "P49458": ["SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane"], "P49459": ["Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "E3 ubiquitin ligases ubiquitinate target proteins", "Antigen processing: Ubiquitination & Proteasome degradation"], "P49585": ["Synthesis of PC"], "P49588": ["Cytosolic tRNA aminoacylation"], "P49589": ["Cytosolic tRNA aminoacylation"], "P49590": ["Mitochondrial tRNA aminoacylation"], "P49591": ["Selenocysteine synthesis", "Cytosolic tRNA aminoacylation"], "P49593": ["Negative regulation of NMDA receptor-mediated neuronal transmission"], "P49619": ["Effects of PIP2 hydrolysis"], "P49638": ["Vitamin E"], "P49639": ["Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "P49641": ["Intra-Golgi traffic", "Reactions specific to the complex N-glycan synthesis pathway"], "P49642": ["Inhibition of replication initiation of damaged DNA by RB1/E2F1", "Polymerase switching on the C-strand of the telomere", "Telomere C-strand synthesis initiation", "DNA replication initiation", "Activation of the pre-replicative complex", "Polymerase switching", "Removal of the Flap Intermediate", "Processive synthesis on the lagging strand"], "P49643": ["Inhibition of replication initiation of damaged DNA by RB1/E2F1", "Polymerase switching on the C-strand of the telomere", "Telomere C-strand synthesis initiation", "DNA replication initiation", "Activation of the pre-replicative complex", "Polymerase switching", "Removal of the Flap Intermediate", "Processive synthesis on the lagging strand"], "P49662": ["NOD1/2 Signaling Pathway"], "P49674": ["WNT mediated activation of DVL", "Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Circadian Clock", "Anchoring of the basal body to the plasma membrane", "Major pathway of rRNA processing in the nucleolus and cytosol", "AURKA Activation by TPX2"], "P49675": ["Pregnenolone biosynthesis"], "P49682": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "P49683": ["Peptide ligand-binding receptors"], "P49685": ["G alpha (s) signalling events"], "P49711": ["Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "P49715": ["Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "P49716": ["Transcriptional regulation of white adipocyte differentiation", "Interleukin-4 and Interleukin-13 signaling"], "P49720": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "P49721": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "P49736": ["Activation of ATR in response to replication stress", "Unwinding of DNA", "Assembly of the pre-replicative complex", "Orc1 removal from chromatin", "Activation of the pre-replicative complex", "Switching of origins to a post-replicative state"], "P49746": ["Signaling by PDGF"], "P49747": ["Integrin cell surface interactions", "ECM proteoglycans"], "P49748": ["XBP1(S) activates chaperone genes", "Beta oxidation of palmitoyl-CoA to myristoyl-CoA"], "P49753": ["Mitochondrial Fatty Acid Beta-Oxidation", "Peroxisomal protein import", "Peroxisomal protein import"], "P49755": ["COPII-mediated vesicle transport", "Cargo concentration in the ER", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "P49757": ["Activated NOTCH1 Transmits Signal to the Nucleus", "Recycling pathway of L1", "Degradation of GLI1 by the proteasome", "Hedgehog 'on' state"], "P49758": ["G alpha (i) signalling events", "G alpha (i) signalling events", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "P49763": ["VEGF ligand-receptor interactions", "VEGF binds to VEGFR leading to receptor dimerization"], "P49765": ["Platelet degranulation ", "VEGF ligand-receptor interactions", "VEGF binds to VEGFR leading to receptor dimerization"], "P49767": ["Platelet degranulation ", "VEGF ligand-receptor interactions", "VEGF binds to VEGFR leading to receptor dimerization"], "P49768": ["Nuclear signaling by ERBB4", "Degradation of the extracellular matrix", "Regulated proteolysis of p75NTR", "NRIF signals cell death from the nucleus", "Activated NOTCH1 Transmits Signal to the Nucleus", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "NOTCH2 Activation and Transmission of Signal to the Nucleus", "EPH-ephrin mediated repulsion of cells", "Neutrophil degranulation", "NOTCH3 Activation and Transmission of Signal to the Nucleus", "NOTCH4 Activation and Transmission of Signal to the Nucleus", "Noncanonical activation of NOTCH3"], "P49770": ["Recycling of eIF2:GDP"], "P49771": ["PI3K Cascade", "Other interleukin signaling", "RAF/MAP kinase cascade"], "P49790": ["ISG15 antiviral mechanism", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "tRNA processing in the nucleus"], "P49792": ["ISG15 antiviral mechanism", "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "RHO GTPases Activate Formins", "tRNA processing in the nucleus", "Mitotic Prometaphase"], "P49795": ["G alpha (q) signalling events", "G alpha (i) signalling events", "G alpha (i) signalling events", "G alpha (z) signalling events"], "P49796": ["G alpha (q) signalling events", "G alpha (i) signalling events"], "P49798": ["G alpha (q) signalling events", "G alpha (i) signalling events", "G alpha (i) signalling events", "G alpha (z) signalling events"], "P49802": ["G alpha (i) signalling events", "G alpha (i) signalling events", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "P49810": ["Nuclear signaling by ERBB4", "Regulated proteolysis of p75NTR", "NRIF signals cell death from the nucleus", "Activated NOTCH1 Transmits Signal to the Nucleus", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "NOTCH2 Activation and Transmission of Signal to the Nucleus", "EPH-ephrin mediated repulsion of cells", "NOTCH3 Activation and Transmission of Signal to the Nucleus", "NOTCH4 Activation and Transmission of Signal to the Nucleus", "Noncanonical activation of NOTCH3"], "P49815": ["Macroautophagy", "Inhibition of TSC complex formation by PKB", "AKT phosphorylates targets in the cytosol", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Constitutive Signaling by AKT1 E17K in Cancer", "TBC/RABGAPs"], "P49821": ["Respiratory electron transport", "Complex I biogenesis"], "P49840": ["AKT phosphorylates targets in the cytosol", "XBP1(S) activates chaperone genes", "Constitutive Signaling by AKT1 E17K in Cancer"], "P49841": ["Degradation of beta-catenin by the destruction complex", "Beta-catenin phosphorylation cascade", "AKT phosphorylates targets in the cytosol", "Regulation of HSF1-mediated heat shock response", "CRMPs in Sema3A signaling", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "B-WICH complex positively regulates rRNA expression", "Misspliced GSK3beta mutants stabilize beta-catenin", "S33 mutants of beta-catenin aren't phosphorylated", "S37 mutants of beta-catenin aren't phosphorylated", "S45 mutants of beta-catenin aren't phosphorylated", "T41 mutants of beta-catenin aren't phosphorylated", "APC truncation mutants have impaired AXIN binding", "AXIN missense mutants destabilize the destruction complex", "Truncations of AMER1 destabilize the destruction complex", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Constitutive Signaling by AKT1 E17K in Cancer", "Ubiquitin-dependent degradation of Cyclin D1", "Regulation of RUNX2 expression and activity"], "P49848": ["HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "P49862": ["Degradation of the extracellular matrix"], "P49888": ["Cytosolic sulfonation of small molecules"], "P49895": ["Regulation of thyroid hormone activity"], "P49902": ["Abacavir metabolism", "Purine catabolism"], "P49908": ["Platelet degranulation "], "P49913": ["Neutrophil degranulation", "Antimicrobial peptides"], "P49914": ["Metabolism of folate and pterines"], "P49915": ["Purine ribonucleoside monophosphate biosynthesis"], "P49916": ["Resolution of AP sites via the single-nucleotide replacement pathway", "APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "HDR through MMEJ (alt-NHEJ)", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER"], "P49917": ["2-LTR circle formation", "Nonhomologous End-Joining (NHEJ)"], "P49918": ["Cyclin D associated events in G1"], "P49959": ["Cytosolic sensors of pathogen-associated DNA ", "DNA Damage/Telomere Stress Induced Senescence", "IRF3-mediated induction of type I IFN", "HDR through Single Strand Annealing (SSA)", "HDR through MMEJ (alt-NHEJ)", "HDR through Homologous Recombination (HRR)", "Sensing of DNA Double Strand Breaks", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Nonhomologous End-Joining (NHEJ)", "Homologous DNA Pairing and Strand Exchange", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Regulation of TP53 Activity through Phosphorylation", "G2/M DNA damage checkpoint", "Meiotic recombination"], "P49961": ["Phosphate bond hydrolysis by NTPDase proteins"], "P50052": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "P50053": ["Essential fructosuria", "Fructose catabolism"], "P50120": ["Retinoid metabolism and transport"], "P50135": ["Metabolism of ingested SeMet, Sec, MeSec into H2Se", "Histidine catabolism"], "P50148": ["Acetylcholine regulates insulin secretion", "Acetylcholine regulates insulin secretion", "G alpha (q) signalling events", "G alpha (q) signalling events", "ADP signalling through P2Y purinoceptor 1", "ADP signalling through P2Y purinoceptor 1", "Thromboxane signalling through TP receptor", "Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "Thrombin signalling through proteinase activated receptors (PARs)"], "P50150": ["Activation of G protein gated Potassium channels", "Glucagon signaling in metabolic regulation", "G-protein activation", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42", "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "P50151": ["Activation of G protein gated Potassium channels", "Glucagon signaling in metabolic regulation", "G-protein activation", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42", "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "P50213": ["Citric acid cycle (TCA cycle)"], "P50225": ["Cytosolic sulfonation of small molecules"], "P50226": ["Cytosolic sulfonation of small molecules"], "P50281": ["Collagen degradation", "Collagen degradation", "Degradation of the extracellular matrix", "Degradation of the extracellular matrix", "Activation of Matrix Metalloproteinases"], "P50336": ["Heme biosynthesis"], "P50391": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "P50395": ["Rho GTPase cycle", "Neutrophil degranulation", "RAB GEFs exchange GTP for GDP on RABs"], "P50402": ["Clearance of Nuclear Envelope Membranes from Chromatin", "Initiation of Nuclear Envelope Reformation", "Depolymerisation of the Nuclear Lamina"], "P50406": ["Serotonin receptors", "G alpha (s) signalling events"], "P50416": ["RORA activates gene expression", "PPARA activates gene expression", "Import of palmitoyl-CoA into the mitochondrial matrix", "Signaling by Retinoic Acid"], "P50440": ["Creatine metabolism"], "P50443": ["Transport and synthesis of PAPS", "Defective SLC26A2 causes chondrodysplasias", "Multifunctional anion exchangers"], "P50452": ["Dissolution of Fibrin Clot"], "P50454": ["Collagen biosynthesis and modifying enzymes"], "P50458": ["Regulation of expression of SLITs and ROBOs"], "P50502": ["Regulation of HSF1-mediated heat shock response"], "P50542-1": ["E3 ubiquitin ligases ubiquitinate target proteins", "Peroxisomal protein import", "Peroxisomal protein import"], "P50542-2": ["E3 ubiquitin ligases ubiquitinate target proteins", "Peroxisomal protein import", "Peroxisomal protein import"], "P50548": ["Oncogene Induced Senescence", "Oncogene Induced Senescence"], "P50552": ["Generation of second messenger molecules", "Signaling by ROBO receptors", "Signaling by ROBO receptors", "Cell-extracellular matrix interactions"], "P50570": ["Toll Like Receptor 4 (TLR4) Cascade", "Retrograde neurotrophin signalling", "Gap junction degradation", "Formation of annular gap junctions", "NOSTRIN mediated eNOS trafficking", "MHC class II antigen presentation", "Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis", "Recycling pathway of L1", "Clathrin-mediated endocytosis"], "P50579": ["Inactivation, recovery and regulation of the phototransduction cascade"], "P50583": ["Detoxification of Reactive Oxygen Species"], "P50591": ["Caspase activation via Death Receptors in the presence of ligand", "Regulation by c-FLIP", "RIPK1-mediated regulated necrosis", "CASP8 activity is inhibited", "Dimerization of procaspase-8", "TRAIL signaling"], "P50613": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Tat-mediated elongation of the HIV-1 transcript", "NoRC negatively regulates rRNA expression", "Formation of Incision Complex in GG-NER", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "Cyclin E associated events during G1/S transition ", "Cyclin D associated events in G1", "Cyclin A/B1/B2 associated events during G2/M transition", "Cyclin A:Cdk2-associated events at S phase entry", "mRNA Capping", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase I Transcription Termination", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE", "RUNX1 regulates transcription of genes involved in differentiation of HSCs"], "P50747": ["Biotin transport and metabolism", "Defective HLCS causes multiple carboxylase deficiency"], "P50748": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "P50750": ["Formation of RNA Pol II elongation complex ", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "Interactions of Tat with host cellular proteins", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Transcription Elongation", "Estrogen-dependent gene expression"], "P50876": ["E3 ubiquitin ligases ubiquitinate target proteins"], "P50897": ["Fatty acyl-CoA biosynthesis"], "P50914": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P50990": ["Prefoldin mediated transfer of substrate to CCT/TriC", "Formation of tubulin folding intermediates by CCT/TriC", "Folding of actin by CCT/TriC", "Association of TriC/CCT with target proteins during biosynthesis", "Association of TriC/CCT with target proteins during biosynthesis", "BBSome-mediated cargo-targeting to cilium", "Neutrophil degranulation", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "P50991": ["Prefoldin mediated transfer of substrate to CCT/TriC", "Formation of tubulin folding intermediates by CCT/TriC", "Folding of actin by CCT/TriC", "Association of TriC/CCT with target proteins during biosynthesis", "Association of TriC/CCT with target proteins during biosynthesis", "BBSome-mediated cargo-targeting to cilium", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "P50993": ["Ion homeostasis", "Ion transport by P-type ATPases"], "P51003": ["Cleavage of Growing Transcript in the Termination Region ", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "P51114": ["Signaling by BRAF and RAF fusions"], "P51124": ["Alternative complement activation"], "P51148": ["Golgi Associated Vesicle Biogenesis", "Neutrophil degranulation", "TBC/RABGAPs", "Clathrin-mediated endocytosis", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "P51149": ["MHC class II antigen presentation", "Neutrophil degranulation", "TBC/RABGAPs", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "P51151": ["Retrograde transport at the Trans-Golgi-Network", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "P51153": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "P51159": ["Insulin processing", "Neutrophil degranulation", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "P51161": ["Recycling of bile acids and salts", "Triglyceride catabolism"], "P51164": ["Ion transport by P-type ATPases"], "P51168": ["Stimuli-sensing channels"], "P51170": ["Stimuli-sensing channels"], "P51172": ["Stimuli-sensing channels"], "P51178": ["Synthesis of IP3 and IP4 in the cytosol"], "P51398": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "P51449": ["Nuclear Receptor transcription pathway", "Interleukin-4 and Interleukin-13 signaling"], "P51449-2": ["RUNX3 Regulates Immune Response and Cell Migration"], "P51451": ["RUNX1 regulates transcription of genes involved in BCR signaling", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P51452": ["ERKs are inactivated"], "P51460": ["G alpha (s) signalling events", "Relaxin receptors"], "P51511": ["Collagen degradation", "Degradation of the extracellular matrix", "Degradation of the extracellular matrix", "Activation of Matrix Metalloproteinases"], "P51512": ["Activation of Matrix Metalloproteinases"], "P51530": ["Removal of the Flap Intermediate from the C-strand", "HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Regulation of TP53 Activity through Phosphorylation", "Removal of the Flap Intermediate", "G2/M DNA damage checkpoint"], "P51531": ["RMTs methylate histone arginines", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "P51532": ["Interleukin-7 signaling", "Formation of the beta-catenin:TCF transactivating complex", "RMTs methylate histone arginines", "Chromatin modifying enzymes", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "P51553": ["Mitochondrial protein import", "Citric acid cycle (TCA cycle)"], "P51570": ["Defective GALK1 can cause Galactosemia II (GALCT2)", "Galactose catabolism"], "P51571": ["SRP-dependent cotranslational protein targeting to membrane"], "P51572": ["Apoptotic cleavage of cellular proteins", "Apoptotic execution phase", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P51575": ["Elevation of cytosolic Ca2+ levels", "Platelet homeostasis", "Neutrophil degranulation"], "P51580": ["Methylation", "Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency)"], "P51582": ["P2Y receptors", "G alpha (i) signalling events"], "P51587": ["HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange", "Presynaptic phase of homologous DNA pairing and strand exchange", "Meiotic recombination"], "P51589": ["Fatty acids", "Xenobiotics", "Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)"], "P51606": ["Synthesis of UDP-N-acetyl-glucosamine"], "P51608-1": ["Transcriptional Regulation by MECP2", "Transcriptional Regulation by MECP2", "Loss of MECP2 binding ability to 5hmC-DNA", "Loss of phosphorylation of MECP2 at T308", "Loss of MECP2 binding ability to the NCoR/SMRT complex", "Loss of MECP2 binding ability to 5mC-DNA", "Regulation of MECP2 expression and activity", "Regulation of MECP2 expression and activity", "MECP2 regulates neuronal receptors and channels", "MECP2 regulates neuronal receptors and channels", "MECP2 regulates transcription of neuronal ligands", "MECP2 regulates transcription factors", "MECP2 regulates transcription of genes involved in GABA signaling"], "P51608-2": ["Transcriptional Regulation by MECP2", "Transcriptional Regulation by MECP2", "Loss of MECP2 binding ability to 5hmC-DNA", "Loss of phosphorylation of MECP2 at T308", "Loss of MECP2 binding ability to the NCoR/SMRT complex", "Loss of MECP2 binding ability to 5mC-DNA", "Regulation of MECP2 expression and activity", "Regulation of MECP2 expression and activity", "MECP2 regulates neuronal receptors and channels", "MECP2 regulates neuronal receptors and channels", "MECP2 regulates transcription of neuronal ligands", "MECP2 regulates transcription factors", "MECP2 regulates transcription of genes involved in GABA signaling"], "P51610": ["Transcriptional activation of mitochondrial biogenesis", "HATs acetylate histones", "UCH proteinases"], "P51617": ["PIP3 activates AKT signaling", "MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "NOD1/2 Signaling Pathway", "p75NTR recruits signalling complexes", "p75NTR recruits signalling complexes", "NF-kB is activated and signals survival", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "activated TAK1 mediates p38 MAPK activation", "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Transcriptional Regulation by MECP2", "Interleukin-1 signaling", "IRAK1 recruits IKK complex", "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "MyD88 dependent cascade initiated on endosome", "MyD88 cascade initiated on plasma membrane"], "P51617-1": ["p75NTR recruits signalling complexes"], "P51648-1": ["Sphingolipid de novo biosynthesis"], "P51648-2": ["Alpha-oxidation of phytanate"], "P51649": ["Degradation of GABA"], "P51654": ["A tetrasaccharide linker sequence is required for GAG synthesis", "HS-GAG biosynthesis", "HS-GAG biosynthesis", "HS-GAG degradation", "Defective B4GALT7 causes EDS, progeroid type", "Defective B3GAT3 causes JDSSDHD", "Defective EXT2 causes exostoses 2", "Defective EXT1 causes exostoses 1, TRPS2 and CHDS", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Defective B3GALT6 causes EDSP2 and SEMDJL1", "Post-translational protein phosphorylation", "Retinoid metabolism and transport"], "P51659": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "alpha-linolenic acid (ALA) metabolism", "Beta-oxidation of pristanoyl-CoA", "Beta-oxidation of very long chain fatty acids", "Peroxisomal protein import", "Peroxisomal protein import", "TYSND1 cleaves peroxisomal proteins"], "P51665": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "Neutrophil degranulation", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "P51668": ["Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Inactivation of APC/C via direct inhibition of the APC/C complex", "TICAM1, RIP1-mediated IKK complex recruitment ", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Signaling by BMP", "Downstream TCR signaling", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "FCERI mediated NF-kB activation", "CLEC7A (Dectin-1) signaling", "Ovarian tumor domain proteases", "CDK-mediated phosphorylation and removal of Cdc6", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "E3 ubiquitin ligases ubiquitinate target proteins", "Neddylation", "Peroxisomal protein import", "Negative regulators of DDX58/IFIH1 signaling", "IKK complex recruitment mediated by RIP1", "Antigen processing: Ubiquitination & Proteasome degradation"], "P51671": ["Interleukin-4 and Interleukin-13 signaling"], "P51677": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "P51679": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "P51681": ["Binding and entry of HIV virion", "Chemokine receptors bind chemokines", "G alpha (i) signalling events", "Interleukin-10 signaling"], "P51684": ["Beta defensins", "Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "P51685": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "P51686": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "P51687": ["Sulfide oxidation to sulfate"], "P51688": ["HS-GAG degradation", "MPS IIIA - Sanfilippo syndrome A"], "P51689": ["Glycosphingolipid metabolism", "The activation of arylsulfatases"], "P51690": ["Glycosphingolipid metabolism", "The activation of arylsulfatases"], "P51692": ["Prolactin receptor signaling", "Interleukin-7 signaling", "Interleukin-7 signaling", "Signaling by SCF-KIT", "Signaling by cytosolic FGFR1 fusion mutants", "Downstream signal transduction", "Signaling by Leptin", "Signaling by Leptin", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "Interleukin-20 family signaling", "Interleukin-15 signaling", "Interleukin-9 signaling", "Interleukin-2 signaling", "Interleukin-2 signaling", "Interleukin-21 signaling", "Erythropoietin activates STAT5", "Growth hormone receptor signaling", "Growth hormone receptor signaling"], "P51784": ["Association of TriC/CCT with target proteins during biosynthesis", "Ub-specific processing proteases"], "P51786": ["Generic Transcription Pathway"], "P51787": ["Voltage gated Potassium channels", "Phase 3 - rapid repolarisation", "Phase 2 - plateau phase"], "P51788": ["Stimuli-sensing channels"], "P51790": ["Stimuli-sensing channels"], "P51793": ["Stimuli-sensing channels"], "P51795": ["Stimuli-sensing channels"], "P51797": ["Stimuli-sensing channels", "Signaling by BRAF and RAF fusions"], "P51798": ["Stimuli-sensing channels"], "P51800": ["Stimuli-sensing channels"], "P51801": ["Stimuli-sensing channels"], "P51805": ["Sema3A PAK dependent Axon repulsion", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "CRMPs in Sema3A signaling", "CRMPs in Sema3A signaling"], "P51809": ["Clathrin derived vesicle budding", "Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "Interleukin-12 signaling"], "P51810": ["Amine ligand-binding receptors", "G alpha (q) signalling events"], "P51811": ["Peptide ligand-binding receptors"], "P51812": ["ERK/MAPK targets", "CREB phosphorylation", "Senescence-Associated Secretory Phenotype (SASP)", "Senescence-Associated Secretory Phenotype (SASP)", "Recycling pathway of L1", "CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling", "RSK activation", "RSK activation", "Gastrin-CREB signalling pathway via PKC and MAPK"], "P51813": ["Apoptotic cleavage of cellular proteins", "Synthesis of PIPs at the plasma membrane"], "P51814": ["Generic Transcription Pathway"], "P51815": ["Generic Transcription Pathway"], "P51817": ["PKA-mediated phosphorylation of CREB", "CREB1 phosphorylation through the activation of Adenylate Cyclase"], "P51828": ["Glucagon signaling in metabolic regulation", "PKA activation", "PKA activation in glucagon signalling", "Adenylate cyclase activating pathway", "Adenylate cyclase inhibitory pathway", "Adenylate cyclase inhibitory pathway", "G alpha (s) signalling events", "G alpha (s) signalling events", "G alpha (i) signalling events", "G alpha (z) signalling events", "G alpha (z) signalling events", "Vasopressin regulates renal water homeostasis via Aquaporins", "Hedgehog 'off' state"], "P51841": ["Inactivation, recovery and regulation of the phototransduction cascade"], "P51843-1": ["Nuclear Receptor transcription pathway"], "P51843-2": ["Nuclear Receptor transcription pathway"], "P51857": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of bile acids and bile salts via 24-hydroxycholesterol", "Synthesis of bile acids and bile salts via 27-hydroxycholesterol"], "P51858": ["XBP1(S) activates chaperone genes"], "P51864": ["Signaling by NODAL", "Regulation of signaling by NODAL"], "P51884": ["Keratan sulfate biosynthesis", "Keratan sulfate degradation", "Integrin cell surface interactions", "ECM proteoglycans", "Defective CHST6 causes MCDC1", "Defective ST3GAL3 causes MCT12 and EIEE15", "Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)"], "P51888": ["Keratan sulfate biosynthesis", "Keratan sulfate degradation", "Defective CHST6 causes MCDC1", "Defective ST3GAL3 causes MCT12 and EIEE15", "Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)"], "P51946": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Tat-mediated elongation of the HIV-1 transcript", "NoRC negatively regulates rRNA expression", "Formation of Incision Complex in GG-NER", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "Cyclin E associated events during G1/S transition ", "Cyclin D associated events in G1", "Cyclin A/B1/B2 associated events during G2/M transition", "Cyclin A:Cdk2-associated events at S phase entry", "mRNA Capping", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase I Transcription Termination", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE", "RUNX1 regulates transcription of genes involved in differentiation of HSCs"], "P51948": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Tat-mediated elongation of the HIV-1 transcript", "NoRC negatively regulates rRNA expression", "Formation of Incision Complex in GG-NER", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "Cyclin E associated events during G1/S transition ", "Cyclin D associated events in G1", "Cyclin A/B1/B2 associated events during G2/M transition", "Cyclin A:Cdk2-associated events at S phase entry", "mRNA Capping", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase I Transcription Termination", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE", "RUNX1 regulates transcription of genes involved in differentiation of HSCs"], "P51955": ["APC-Cdc20 mediated degradation of Nek2A", "Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "P51959": ["Regulation of TP53 Degradation"], "P51965": ["ISG15 antiviral mechanism", "Inactivation of APC/C via direct inhibition of the APC/C complex", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "E3 ubiquitin ligases ubiquitinate target proteins", "Antigen processing: Ubiquitination & Proteasome degradation"], "P51970": ["Respiratory electron transport", "Complex I biogenesis"], "P51991": ["mRNA Splicing - Major Pathway", "Processing of Capped Intron-Containing Pre-mRNA"], "P52209": ["Pentose phosphate pathway"], "P52272": ["FGFR2 alternative splicing", "mRNA Splicing - Major Pathway", "Processing of Capped Intron-Containing Pre-mRNA"], "P52292": ["CaMK IV-mediated phosphorylation of CREB", "ISG15 antiviral mechanism", "NS1 Mediated Effects on Host Pathways", "CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "Sensing of DNA Double Strand Breaks", "Estrogen-dependent gene expression"], "P52294": ["ISG15 antiviral mechanism", "Integration of provirus", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Vpr-mediated nuclear import of PICs", "Activation of DNA fragmentation factor"], "P52298": ["Cleavage of Growing Transcript in the Termination Region ", "SLBP independent Processing of Histone Pre-mRNAs", "Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Abortive elongation of HIV-1 transcript in the absence of Tat", "snRNP Assembly", "RNA Polymerase II Pre-transcription Events", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "mRNA 3'-end processing", "Processing of Capped Intron-Containing Pre-mRNA", "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "Processing of Intronless Pre-mRNAs", "Signaling by FGFR2 IIIa TM", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P52333": ["Interleukin-7 signaling", "Interleukin-7 signaling", "RAF/MAP kinase cascade", "Interleukin-4 and Interleukin-13 signaling", "Interleukin-20 family signaling", "Interleukin-15 signaling", "Interleukin-15 signaling", "Interleukin-9 signaling", "Interleukin-2 signaling", "Interleukin-21 signaling", "Interleukin receptor SHC signaling"], "P52429": ["Effects of PIP2 hydrolysis"], "P52434": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Abortive elongation of HIV-1 transcript in the absence of Tat", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "Viral Messenger RNA Synthesis", "Cytosolic sensors of pathogen-associated DNA ", "MicroRNA (miRNA) biogenesis", "NoRC negatively regulates rRNA expression", "Transcriptional regulation of pluripotent stem cells", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "PIWI-interacting RNA (piRNA) biogenesis", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase III Chain Elongation", "RNA Polymerase I Transcription Termination", "RNA Polymerase III Transcription Termination", "RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Pol II CTD phosphorylation and interaction with CE", "Signaling by FGFR2 IIIa TM", "Estrogen-dependent gene expression"], "P52435": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Abortive elongation of HIV-1 transcript in the absence of Tat", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "Viral Messenger RNA Synthesis", "MicroRNA (miRNA) biogenesis", "Transcriptional regulation of pluripotent stem cells", "Transcriptional regulation by small RNAs", "PIWI-interacting RNA (piRNA) biogenesis", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE", "Signaling by FGFR2 IIIa TM", "Estrogen-dependent gene expression"], "P52564": ["NOD1/2 Signaling Pathway", "Oxidative Stress Induced Senescence", "CDO in myogenesis", "activated TAK1 mediates p38 MAPK activation", "PI5P Regulates TP53 Acetylation", "Interleukin-1 signaling"], "P52564-1": ["Uptake and function of anthrax toxins"], "P52565": ["Axonal growth inhibition (RHOA activation)", "Rho GTPase cycle", "Axonal growth stimulation"], "P52566": ["Rho GTPase cycle"], "P52569-1": ["Amino acid transport across the plasma membrane"], "P52569-2": ["Amino acid transport across the plasma membrane"], "P52594": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "P52597": ["FGFR2 alternative splicing", "mRNA Splicing - Major Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "P52616": ["The IPAF inflammasome", "The IPAF inflammasome"], "P52630": ["Interleukin-20 family signaling", "Interferon alpha/beta signaling", "Regulation of IFNA signaling", "Regulation of IFNA signaling"], "P52655": ["HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "RNA Polymerase II Pre-transcription Events", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "Estrogen-dependent gene expression"], "P52657": ["HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "RNA Polymerase II Pre-transcription Events", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "Estrogen-dependent gene expression"], "P52701": ["Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "Defective Mismatch Repair Associated With MSH2", "Defective Mismatch Repair Associated With MSH6"], "P52732": ["MHC class II antigen presentation", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "P52735": ["GPVI-mediated activation cascade", "GPVI-mediated activation cascade", "NRAGE signals death through JNK", "Rho GTPase cycle", "Regulation of actin dynamics for phagocytic cup formation", "DAP12 signaling", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "EPH-ephrin mediated repulsion of cells", "G alpha (12/13) signalling events", "VEGFA-VEGFR2 Pathway", "VEGFA-VEGFR2 Pathway", "Signal transduction by L1", "VEGFR2 mediated vascular permeability"], "P52736": ["Generic Transcription Pathway"], "P52737": ["Generic Transcription Pathway"], "P52738": ["Generic Transcription Pathway"], "P52739": ["SUMOylation of transcription cofactors"], "P52742": ["Generic Transcription Pathway"], "P52744": ["Generic Transcription Pathway"], "P52747": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "P52756": ["mRNA Splicing - Major Pathway"], "P52757": ["Rho GTPase cycle"], "P52758": ["Threonine catabolism"], "P52788": ["Metabolism of polyamines"], "P52789": ["Glycolysis"], "P52790": ["Neutrophil degranulation", "Glycolysis"], "P52797": ["EPH-Ephrin signaling", "EPH-Ephrin signaling", "EPHA-mediated growth cone collapse", "EPHA-mediated growth cone collapse", "EPH-ephrin mediated repulsion of cells", "EPH-ephrin mediated repulsion of cells"], "P52798": ["EPH-Ephrin signaling", "EPH-Ephrin signaling", "EPHA-mediated growth cone collapse", "EPHA-mediated growth cone collapse", "EPH-ephrin mediated repulsion of cells", "EPH-ephrin mediated repulsion of cells"], "P52799": ["EPH-Ephrin signaling", "EPH-Ephrin signaling", "EPHB-mediated forward signaling", "EPHB-mediated forward signaling", "Ephrin signaling", "Ephrin signaling", "EPH-ephrin mediated repulsion of cells"], "P52803": ["EPH-Ephrin signaling", "EPH-Ephrin signaling", "EPHA-mediated growth cone collapse", "EPHA-mediated growth cone collapse", "EPH-ephrin mediated repulsion of cells", "EPH-ephrin mediated repulsion of cells"], "P52815": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "P52824": ["Effects of PIP2 hydrolysis"], "P52848": ["HS-GAG biosynthesis"], "P52849": ["HS-GAG biosynthesis"], "P52888": ["Antigen processing: Ubiquitination & Proteasome degradation"], "P52895": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of bile acids and bile salts via 24-hydroxycholesterol", "Synthesis of bile acids and bile salts via 27-hydroxycholesterol"], "P52907": ["MHC class II antigen presentation", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic", "Advanced glycosylation endproduct receptor signaling", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "Factors involved in megakaryocyte development and platelet production", "Factors involved in megakaryocyte development and platelet production"], "P52926": ["Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "P52945": ["Regulation of gene expression in beta cells", "Regulation of gene expression in early pancreatic precursor cells"], "P52948-3": ["ISG15 antiviral mechanism", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "tRNA processing in the nucleus"], "P52948-4": ["ISG15 antiviral mechanism", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "tRNA processing in the nucleus"], "P52948-5": ["ISG15 antiviral mechanism", "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "RHO GTPases Activate Formins", "tRNA processing in the nucleus", "Mitotic Prometaphase"], "P52952": ["YAP1- and WWTR1 (TAZ)-stimulated gene expression", "Physiological factors"], "P52961": ["Alpha-defensins"], "P53004": ["Heme degradation"], "P53007": ["Gluconeogenesis", "Fatty acyl-CoA biosynthesis"], "P53041": ["Negative regulation of MAPK pathway", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "ESR-mediated signaling"], "P53350": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Polo-like kinase mediated events", "Golgi Cisternae Pericentriolar Stack Reorganization", "Golgi Cisternae Pericentriolar Stack Reorganization", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Phosphorylation of the APC/C", "Phosphorylation of Emi1", "Condensation of Prophase Chromosomes", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Regulation of PLK1 Activity at G2/M Transition", "Activation of NIMA Kinases NEK9, NEK6, NEK7", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "RHO GTPases Activate Formins", "Mitotic Prometaphase", "Mitotic Metaphase/Anaphase Transition", "Mitotic Telophase/Cytokinesis", "Cyclin A/B1/B2 associated events during G2/M transition", "The role of GTSE1 in G2/M progression after G2 checkpoint", "AURKA Activation by TPX2"], "P53355": ["Caspase activation via Dependence Receptors in the absence of ligand"], "P53365": ["Retrograde transport at the Trans-Golgi-Network"], "P53384": ["Cytosolic iron-sulfur cluster assembly"], "P53396": ["ChREBP activates metabolic gene expression", "Neutrophil degranulation", "Fatty acyl-CoA biosynthesis"], "P53420": ["Collagen degradation", "Collagen degradation", "Extracellular matrix organization", "Collagen biosynthesis and modifying enzymes", "Signaling by PDGF", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "Integrin cell surface interactions", "Anchoring fibril formation", "Crosslinking of collagen fibrils", "Laminin interactions", "Laminin interactions", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "NCAM1 interactions", "Collagen chain trimerization"], "P53539": ["Estrogen-dependent gene expression"], "P53582": ["Inactivation, recovery and regulation of the phototransduction cascade"], "P53597": ["Citric acid cycle (TCA cycle)"], "P53602": ["Cholesterol biosynthesis", "Activation of gene expression by SREBF (SREBP)", "Synthesis of Dolichyl-phosphate"], "P53611": ["TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "RAB geranylgeranylation"], "P53618": ["Neutrophil degranulation", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "P53621": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "P53634": ["COPII-mediated vesicle transport", "MHC class II antigen presentation", "Cargo concentration in the ER", "Neutrophil degranulation"], "P53667": ["Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "EPHB-mediated forward signaling", "Sema3A PAK dependent Axon repulsion", "Sema3A PAK dependent Axon repulsion", "Sema4D induced cell migration and growth-cone collapse", "RHO GTPases Activate ROCKs", "RHO GTPases activate PAKs"], "P53671": ["EPHB-mediated forward signaling", "Sema4D induced cell migration and growth-cone collapse", "RHO GTPases Activate ROCKs"], "P53675": ["Gap junction degradation", "Formation of annular gap junctions", "EPH-ephrin mediated repulsion of cells", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "P53680": ["Nef Mediated CD4 Down-regulation", "Retrograde neurotrophin signalling", "Retrograde neurotrophin signalling", "Nef Mediated CD8 Down-regulation", "MHC class II antigen presentation", "EPH-ephrin mediated repulsion of cells", "Recycling pathway of L1", "Recycling pathway of L1", "WNT5A-dependent internalization of FZD4", "WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "VLDLR internalisation and degradation", "LDL clearance"], "P53680-1": ["Trafficking of GluR2-containing AMPA receptors"], "P53708": ["Molecules associated with elastic fibres", "Integrin cell surface interactions", "Integrin cell surface interactions", "ECM proteoglycans"], "P53778": ["NOD1/2 Signaling Pathway", "p38MAPK events", "Activation of PPARGC1A (PGC-1alpha) by phosphorylation", "CDO in myogenesis", "CDO in myogenesis", "DSCAM interactions", "VEGFA-VEGFR2 Pathway"], "P53779": ["Oxidative Stress Induced Senescence", "FCERI mediated MAPK activation", "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "Activation of the AP-1 family of transcription factors"], "P53794": ["Inositol transporters"], "P53803": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Abortive elongation of HIV-1 transcript in the absence of Tat", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "Viral Messenger RNA Synthesis", "Cytosolic sensors of pathogen-associated DNA ", "MicroRNA (miRNA) biogenesis", "NoRC negatively regulates rRNA expression", "Transcriptional regulation of pluripotent stem cells", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "PIWI-interacting RNA (piRNA) biogenesis", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase III Chain Elongation", "RNA Polymerase I Transcription Termination", "RNA Polymerase III Transcription Termination", "RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Pol II CTD phosphorylation and interaction with CE", "Signaling by FGFR2 IIIa TM", "Estrogen-dependent gene expression"], "P53816": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PS", "Acyl chain remodelling of PE", "Acyl chain remodelling of PI"], "P53985": ["Basigin interactions", "Proton-coupled monocarboxylate transport", "Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)", "Pyruvate metabolism"], "P53990": ["Neutrophil degranulation"], "P53992": ["Regulation of cholesterol biosynthesis by SREBP (SREBF)", "COPII-mediated vesicle transport", "MHC class II antigen presentation", "Cargo concentration in the ER", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P54105": ["snRNP Assembly"], "P54108": ["Neutrophil degranulation"], "P54132": ["SUMOylation of DNA damage response and repair proteins", "HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Regulation of TP53 Activity through Phosphorylation", "G2/M DNA damage checkpoint", "Meiotic recombination"], "P54136": ["SeMet incorporation into proteins", "Cytosolic tRNA aminoacylation"], "P54198": ["Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "P54219": ["Na+/Cl- dependent neurotransmitter transporters"], "P54252": ["Josephin domain DUBs", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes"], "P54259": ["Regulation of PTEN gene transcription"], "P54274": ["Meiotic synapsis", "Packaging Of Telomere Ends", "DNA Damage/Telomere Stress Induced Senescence"], "P54278": ["Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "Defective Mismatch Repair Associated With MLH1", "Defective Mismatch Repair Associated With PMS2", "TP53 Regulates Transcription of DNA Repair Genes"], "P54284": ["Presynaptic depolarization and calcium channel opening", "Adrenaline,noradrenaline inhibits insulin secretion", "NCAM1 interactions", "Regulation of insulin secretion", "Regulation of insulin secretion", "Phase 0 - rapid depolarisation", "Phase 2 - plateau phase"], "P54289": ["Phase 0 - rapid depolarisation", "Phase 2 - plateau phase"], "P54315": ["Digestion of dietary lipid"], "P54317": ["Digestion of dietary lipid"], "P54368": ["Regulation of ornithine decarboxylase (ODC)"], "P54577": ["Cytosolic tRNA aminoacylation"], "P54578": ["Ub-specific processing proteases"], "P54619": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Macroautophagy", "Activation of PPARGC1A (PGC-1alpha) by phosphorylation", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Regulation of TP53 Activity through Phosphorylation", "Activation of AMPK downstream of NMDARs"], "P54646": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Macroautophagy", "AMPK inhibits chREBP transcriptional activation activity", "AMPK inhibits chREBP transcriptional activation activity", "Import of palmitoyl-CoA into the mitochondrial matrix", "Activation of PPARGC1A (PGC-1alpha) by phosphorylation", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Regulation of TP53 Activity through Phosphorylation", "Activation of AMPK downstream of NMDARs"], "P54652": ["Meiotic synapsis", "Regulation of HSF1-mediated heat shock response", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Attenuation phase"], "P54687": ["Branched-chain amino acid catabolism"], "P54707": ["Ion transport by P-type ATPases"], "P54709": ["Basigin interactions", "Ion homeostasis", "Ion transport by P-type ATPases"], "P54710": ["Ion homeostasis", "Ion transport by P-type ATPases"], "P54725": ["Josephin domain DUBs", "DNA Damage Recognition in GG-NER", "Formation of Incision Complex in GG-NER"], "P54727": ["N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "Josephin domain DUBs", "DNA Damage Recognition in GG-NER", "Formation of Incision Complex in GG-NER"], "P54750": ["Cam-PDE 1 activation", "cGMP effects", "G alpha (s) signalling events"], "P54753": ["EPH-Ephrin signaling", "EPH-Ephrin signaling", "EPHB-mediated forward signaling", "EPHB-mediated forward signaling", "Ephrin signaling", "Ephrin signaling", "EPH-ephrin mediated repulsion of cells"], "P54756": ["EPH-Ephrin signaling", "EPH-Ephrin signaling", "EPHA-mediated growth cone collapse", "EPHA-mediated growth cone collapse", "EPH-ephrin mediated repulsion of cells", "EPH-ephrin mediated repulsion of cells"], "P54760": ["EPH-Ephrin signaling", "EPH-Ephrin signaling", "EPHB-mediated forward signaling", "EPHB-mediated forward signaling", "Ephrin signaling", "Ephrin signaling", "EPH-ephrin mediated repulsion of cells"], "P54762": ["EPH-Ephrin signaling", "EPH-Ephrin signaling", "EPHB-mediated forward signaling", "EPHB-mediated forward signaling", "Ephrin signaling", "Ephrin signaling", "EPH-ephrin mediated repulsion of cells"], "P54764": ["EPH-Ephrin signaling", "EPH-Ephrin signaling", "EPHA-mediated growth cone collapse", "EPHA-mediated growth cone collapse", "EPH-ephrin mediated repulsion of cells", "EPH-ephrin mediated repulsion of cells"], "P54793": ["Glycosphingolipid metabolism", "The activation of arylsulfatases"], "P54802": ["HS-GAG degradation", "MPS IIIB - Sanfilippo syndrome B"], "P54803": ["Glycosphingolipid metabolism"], "P54819": ["Interconversion of nucleotide di- and triphosphates"], "P54826": ["Ligand-receptor interactions", "Activation of SMO"], "P54829": ["Interleukin-37 signaling"], "P54840": ["Glycogen synthesis", "Glycogen storage disease type 0 (liver GYS2)", "Glycogen storage disease type IV (GBE1)"], "P54855": ["Glucuronidation"], "P54868": ["PPARA activates gene expression", "Synthesis of Ketone Bodies"], "P54886-1": ["Amino acid synthesis and interconversion (transamination)"], "P54886-2": ["Amino acid synthesis and interconversion (transamination)"], "P54920": ["COPII-mediated vesicle transport", "Golgi Associated Vesicle Biogenesis", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network"], "P55001": ["Elastic fibre formation", "Molecules associated with elastic fibres", "Molecules associated with elastic fibres"], "P55010": ["Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "P55011": ["Cation-coupled Chloride cotransporters"], "P55017": ["Cation-coupled Chloride cotransporters", "Defective SLC12A3 causes Gitelman syndrome (GS)"], "P55036": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "P55055": ["PPARA activates gene expression", "Nuclear Receptor transcription pathway", "SUMOylation of intracellular receptors", "VLDLR internalisation and degradation"], "P55056": ["VLDL assembly", "VLDL clearance", "VLDL clearance"], "P55058-1": ["HDL remodeling"], "P55058-2": ["HDL remodeling"], "P55064": ["Passive transport by Aquaporins"], "P55072": ["Translesion Synthesis by POLH", "HSF1 activation", "ABC-family proteins mediated transport", "N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Defective CFTR causes cystic fibrosis", "Josephin domain DUBs", "Ovarian tumor domain proteases", "Neutrophil degranulation", "E3 ubiquitin ligases ubiquitinate target proteins", "Protein methylation"], "P55073": ["Regulation of thyroid hormone activity"], "P55075-1": ["PI3K Cascade", "PIP3 activates AKT signaling", "Signaling by activated point mutants of FGFR1", "Signaling by activated point mutants of FGFR3", "FGFR4 ligand binding and activation", "FGFR3b ligand binding and activation", "FGFR3c ligand binding and activation", "FGFR1c ligand binding and activation", "FGFR2c ligand binding and activation", "FGFR3 mutant receptor activation", "Activated point mutants of FGFR2", "Constitutive Signaling by Aberrant PI3K in Cancer", "Phospholipase C-mediated cascade: FGFR1", "Phospholipase C-mediated cascade; FGFR2", "Phospholipase C-mediated cascade; FGFR3", "Phospholipase C-mediated cascade; FGFR4", "Downstream signaling of activated FGFR1", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "PI-3K cascade:FGFR3", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "PI-3K cascade:FGFR4", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "Signaling by FGFR2 in disease", "Signaling by FGFR1 in disease", "FGFRL1 modulation of FGFR1 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Signaling by FGFR3 point mutants in cancer"], "P55081": ["Molecules associated with elastic fibres"], "P55082": ["Molecules associated with elastic fibres"], "P55083": ["Molecules associated with elastic fibres"], "P55084": ["Acyl chain remodeling of CL", "Beta oxidation of myristoyl-CoA to lauroyl-CoA", "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids", "Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "Beta oxidation of hexanoyl-CoA to butanoyl-CoA"], "P55085": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "P55087": ["Vasopressin regulates renal water homeostasis via Aquaporins", "Passive transport by Aquaporins"], "P55089": ["Class B/2 (Secretin family receptors)", "Synthesis, secretion, and deacylation of Ghrelin"], "P55103": ["Glycoprotein hormones"], "P55145": ["Platelet degranulation "], "P55157": ["VLDL assembly", "Chylomicron assembly"], "P55160": ["Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs", "Neutrophil degranulation"], "P55196-2": ["Adherens junctions interactions", "Adherens junctions interactions"], "P55199": ["Formation of RNA Pol II elongation complex ", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "RNA Polymerase II Pre-transcription Events", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "TP53 Regulates Transcription of DNA Repair Genes", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Transcription Elongation"], "P55201": ["HATs acetylate histones", "Regulation of TP53 Activity through Acetylation"], "P55210": ["Activation of caspases through apoptosome-mediated cleavage", "SMAC (DIABLO) binds to IAPs ", "SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ", "Apoptotic cleavage of cellular proteins", "SMAC, XIAP-regulated apoptotic response", "Caspase-mediated cleavage of cytoskeletal proteins"], "P55211": ["Formation of apoptosome", "Activation of caspases through apoptosome-mediated cleavage", "SMAC (DIABLO) binds to IAPs ", "SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ", "NOD1/2 Signaling Pathway", "AKT phosphorylates targets in the cytosol", "Caspase activation via Dependence Receptors in the absence of ligand", "Constitutive Signaling by AKT1 E17K in Cancer", "Regulation of the apoptosome activity", "Regulation of the apoptosome activity"], "P55212": ["Apoptotic cleavage of cellular proteins", "Caspase-mediated cleavage of cytoskeletal proteins", "Breakdown of the nuclear lamina", "TP53 Regulates Transcription of Caspase Activators and Caspases"], "P55259": ["Post-translational modification: synthesis of GPI-anchored proteins"], "P55263": ["Purine salvage"], "P55265": ["C6 deamination of adenosine", "Formation of editosomes by ADAR proteins", "Interferon alpha/beta signaling"], "P55268": ["Laminin interactions", "Laminin interactions", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "MET activates PTK2 signaling", "Post-translational protein phosphorylation"], "P55273": ["Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "Oncogene Induced Senescence", "Cyclin D associated events in G1"], "P55283": ["CDO in myogenesis", "CDO in myogenesis", "Adherens junctions interactions"], "P55285": ["Adherens junctions interactions"], "P55286": ["Adherens junctions interactions"], "P55287": ["Adherens junctions interactions"], "P55289": ["Adherens junctions interactions"], "P55290": ["Adherens junctions interactions"], "P55291": ["CDO in myogenesis", "CDO in myogenesis", "Adherens junctions interactions"], "P55316": ["Regulation of MECP2 expression and activity", "FOXO-mediated transcription of cell cycle genes"], "P55317": ["Estrogen-dependent gene expression"], "P55318": ["Regulation of gene expression in beta cells"], "P55327": ["Golgi Associated Vesicle Biogenesis"], "P55347": ["Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "P55735": ["ISG15 antiviral mechanism", "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "COPII-mediated vesicle transport", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "RHO GTPases Activate Formins", "tRNA processing in the nucleus", "Mitotic Prometaphase", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P55769": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "P55773-2": ["G alpha (q) signalling events", "G alpha (i) signalling events", "Formyl peptide receptors bind formyl peptides and many other ligands"], "P55786": ["Antigen processing: Ubiquitination & Proteasome degradation"], "P55789": ["Mitochondrial protein import"], "P55795": ["mRNA Splicing - Major Pathway", "Processing of Capped Intron-Containing Pre-mRNA"], "P55809": ["Utilization of Ketone Bodies"], "P55851": ["The fatty acid cycling model", "The proton buffering model"], "P55854": ["SUMO is conjugated to E1 (UBA2:SAE1)", "SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "SUMO is proteolytically processed", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of transcription factors", "SUMOylation of transcription cofactors", "SUMOylation of intracellular receptors", "SUMOylation of intracellular receptors", "SUMOylation of chromatin organization proteins", "SUMOylation of DNA replication proteins", "SUMOylation of immune response proteins", "Formation of Incision Complex in GG-NER"], "P55884": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "P55895": ["Interleukin-7 signaling", "MAPK6/MAPK4 signaling"], "P55916": ["The fatty acid cycling model", "The proton buffering model"], "P55957": ["Activation of BAD and translocation to mitochondria ", "Activation and oligomerization of BAK protein", "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "Activation, translocation and oligomerization of BAX", "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "Activation, myristolyation of BID and translocation to mitochondria"], "P56134": ["Formation of ATP by chemiosmotic coupling", "Cristae formation"], "P56159": ["NCAM1 interactions", "RAF/MAP kinase cascade", "RET signaling"], "P56178": ["Regulation of RUNX2 expression and activity"], "P56179": ["Regulation of RUNX2 expression and activity"], "P56180": ["Synthesis of PIPs at the Golgi membrane"], "P56181": ["Respiratory electron transport", "Complex I biogenesis"], "P56182": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "P56192": ["SeMet incorporation into proteins", "Cytosolic tRNA aminoacylation"], "P56199": ["Integrin cell surface interactions", "Integrin cell surface interactions", "Laminin interactions", "Other semaphorin interactions", "Smooth Muscle Contraction", "CHL1 interactions", "Platelet Adhesion to exposed collagen"], "P56202": ["Platelet degranulation "], "P56211": ["MASTL Facilitates Mitotic Progression", "MASTL Facilitates Mitotic Progression"], "P56277": ["Mitochondrial protein import"], "P56282": ["Recognition of DNA damage by PCNA-containing replication complex", "Telomere C-strand synthesis initiation", "PCNA-Dependent Long Patch Base Excision Repair", "Termination of translesion DNA synthesis", "HDR through Homologous Recombination (HRR)", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "DNA replication initiation", "Activation of the pre-replicative complex"], "P56373": ["Elevation of cytosolic Ca2+ levels", "Platelet homeostasis"], "P56377": ["Nef mediated downregulation of MHC class I complex cell surface expression", "MHC class II antigen presentation", "Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis"], "P56381": ["Formation of ATP by chemiosmotic coupling", "Cristae formation"], "P56385": ["Formation of ATP by chemiosmotic coupling", "Cristae formation"], "P56524": ["NOTCH1 Intracellular Domain Regulates Transcription", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "SUMOylation of intracellular receptors", "SUMOylation of chromatin organization proteins", "RUNX2 regulates chondrocyte maturation", "RUNX3 regulates p14-ARF"], "P56539": ["Smooth Muscle Contraction", "Smooth Muscle Contraction"], "P56545": ["Repression of WNT target genes", "TCF7L2 mutants don't bind CTBP"], "P56556": ["Respiratory electron transport", "Complex I biogenesis"], "P56589": ["ABC transporters in lipid homeostasis"], "P56696": ["Voltage gated Potassium channels"], "P56703": ["TCF dependent signaling in response to WNT", "WNT ligand biogenesis and trafficking", "WNT ligand biogenesis and trafficking", "Class B/2 (Secretin family receptors)"], "P56704": ["TCF dependent signaling in response to WNT", "TCF dependent signaling in response to WNT", "WNT ligand biogenesis and trafficking", "WNT ligand biogenesis and trafficking", "Class B/2 (Secretin family receptors)", "Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Regulation of FZD by ubiquitination", "RNF mutants show enhanced WNT signaling and proliferation"], "P56705": ["TCF dependent signaling in response to WNT", "WNT ligand biogenesis and trafficking", "WNT ligand biogenesis and trafficking", "Class B/2 (Secretin family receptors)", "Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "PCP/CE pathway", "PCP/CE pathway"], "P56706": ["WNT ligand biogenesis and trafficking", "WNT ligand biogenesis and trafficking", "Class B/2 (Secretin family receptors)"], "P56746": ["Tight junction interactions"], "P56747": ["Tight junction interactions"], "P56748": ["Tight junction interactions"], "P56749": ["Tight junction interactions"], "P56750": ["Tight junction interactions"], "P56817": ["Amyloid fiber formation"], "P56856": ["Tight junction interactions"], "P56880": ["Tight junction interactions"], "P56937": ["Cholesterol biosynthesis"], "P56945": ["Downstream signal transduction", "p130Cas linkage to MAPK signaling for integrins", "VEGFA-VEGFR2 Pathway", "VEGFA-VEGFR2 Pathway", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases"], "P56962": ["COPII-mediated vesicle transport"], "P56975": ["Signaling by ERBB2", "Signaling by ERBB4", "SHC1 events in ERBB2 signaling", "SHC1 events in ERBB2 signaling", "PI3K events in ERBB4 signaling", "SHC1 events in ERBB4 signaling", "Nuclear signaling by ERBB4", "PIP3 activates AKT signaling", "GRB2 events in ERBB2 signaling", "PI3K events in ERBB2 signaling", "Constitutive Signaling by Aberrant PI3K in Cancer", "RAF/MAP kinase cascade", "ERBB2 Regulates Cell Motility", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "ERBB2 Activates PTK6 Signaling", "Downregulation of ERBB2 signaling"], "P57053": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "P57054": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "P57057": ["Gluconeogenesis"], "P57059": ["Circadian Clock"], "P57081": ["tRNA modification in the nucleus and cytosol"], "P57087": ["Cell surface interactions at the vascular wall", "Integrin cell surface interactions"], "P57103": ["Reduction of cytosolic Ca++ levels", "Sodium/Calcium exchangers", "Ion homeostasis", "Mitochondrial calcium ion transport"], "P57678": ["snRNP Assembly"], "P57679": ["Hedgehog 'on' state", "Activation of SMO", "Activation of SMO"], "P57723": ["TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "Transcriptional activation of cell cycle inhibitor p21 ", "FOXO-mediated transcription of cell cycle genes"], "P57729": ["RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "P57735": ["RAB geranylgeranylation"], "P57739": ["Tight junction interactions"], "P57740": ["ISG15 antiviral mechanism", "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "RHO GTPases Activate Formins", "tRNA processing in the nucleus", "Mitotic Prometaphase"], "P57764": ["Neutrophil degranulation"], "P57771": ["G alpha (i) signalling events", "G alpha (i) signalling events"], "P57772": ["Selenocysteine synthesis"], "P57773": ["Gap junction assembly"], "P57775": ["Association of TriC/CCT with target proteins during biosynthesis", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "P57789": ["TWIK related potassium channel (TREK)", "Phase 4 - resting membrane potential"], "P58004": ["TP53 Regulates Metabolic Genes"], "P58005": ["TP53 Regulates Metabolic Genes"], "P58012": ["SUMOylation of transcription factors"], "P58166": ["Glycoprotein hormones"], "P58170": ["Olfactory Signaling Pathway"], "P58173": ["Olfactory Signaling Pathway"], "P58180": ["Olfactory Signaling Pathway"], "P58181": ["Olfactory Signaling Pathway"], "P58182": ["Olfactory Signaling Pathway"], "P58215": ["Elastic fibre formation", "Crosslinking of collagen fibrils"], "P58294": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "P58335-1": ["Uptake and function of anthrax toxins"], "P58335-4": ["Uptake and function of anthrax toxins"], "P58397": ["Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "P58400": ["Neurexins and neuroligins", "Neurexins and neuroligins"], "P58401": ["Neurexins and neuroligins", "Neurexins and neuroligins"], "P58549": ["Ion homeostasis", "Ion transport by P-type ATPases"], "P58753": ["ER-Phagosome pathway", "MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "MyD88 deficiency (TLR2/4)", "IRAK4 deficiency (TLR2/4)"], "P58876": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "HATs acetylate histones", "HATs acetylate histones", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Ub-specific processing proteases", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "E3 ubiquitin ligases ubiquitinate target proteins", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "P59025": ["Olfactory Signaling Pathway"], "P59095": ["Pregnenolone biosynthesis"], "P59190": ["RAB geranylgeranylation"], "P59510": ["Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "P59533": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "P59534": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "P59535": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "P59536": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "P59537": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "P59538": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "P59539": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "P59540": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "P59541": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "P59542": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "P59543": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "P59544": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "P59551": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "P59646": ["Ion homeostasis", "Ion transport by P-type ATPases"], "P59665": ["Defensins", "Alpha-defensins", "Neutrophil degranulation"], "P59666": ["Defensins", "Alpha-defensins"], "P59768": ["Activation of G protein gated Potassium channels", "Glucagon signaling in metabolic regulation", "G-protein activation", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42", "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "P59796": ["Detoxification of Reactive Oxygen Species"], "P59827": ["Antimicrobial peptides"], "P59861": ["Beta defensins", "Defensins"], "P59901": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "P59922": ["Olfactory Signaling Pathway"], "P59923": ["Generic Transcription Pathway"], "P59990": ["Keratinization"], "P59991": ["Keratinization"], "P59998": ["Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "EPHB-mediated forward signaling", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs", "Clathrin-mediated endocytosis"], "P60006": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6"], "P60014": ["Keratinization"], "P60022": ["Beta defensins", "Defensins"], "P60033": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Regulation of Complement cascade"], "P60059": ["ER-Phagosome pathway", "SRP-dependent cotranslational protein targeting to membrane", "XBP1(S) activates chaperone genes"], "P60174": ["Glycolysis", "Gluconeogenesis"], "P60228": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "P60328": ["Keratinization"], "P60329": ["Keratinization"], "P60331": ["Keratinization"], "P60368": ["Keratinization"], "P60369": ["Keratinization"], "P60370": ["Keratinization"], "P60371": ["Keratinization"], "P60372": ["Keratinization"], "P60409": ["Keratinization"], "P60410": ["Keratinization"], "P60411": ["Keratinization"], "P60412": ["Keratinization"], "P60413": ["Keratinization"], "P60468": ["ER-Phagosome pathway", "SRP-dependent cotranslational protein targeting to membrane", "XBP1(S) activates chaperone genes"], "P60484": ["Synthesis of PIPs at the plasma membrane", "Synthesis of IP3 and IP4 in the cytosol", "Negative regulation of the PI3K/AKT network", "Downstream TCR signaling", "TP53 Regulates Metabolic Genes", "PTEN Loss of Function in Cancer", "Ub-specific processing proteases", "Ovarian tumor domain proteases", "Regulation of PTEN mRNA translation", "Regulation of PTEN localization", "Regulation of PTEN stability and activity", "Transcriptional Regulation by MECP2"], "P60510": ["Processing of DNA double-strand break ends"], "P60520": ["Macroautophagy", "TBC/RABGAPs"], "P60568": ["RAF/MAP kinase cascade", "RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "Interleukin-2 signaling", "Interleukin receptor SHC signaling"], "P60604": ["Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Antigen processing: Ubiquitination & Proteasome degradation"], "P60660": ["EPHA-mediated growth cone collapse", "Sema4D induced cell migration and growth-cone collapse", "Smooth Muscle Contraction", "RHO GTPases activate PKNs", "RHO GTPases activate CIT", "RHO GTPases Activate ROCKs", "RHO GTPases activate PAKs", "RHO GTPases activate PAKs"], "P60709": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Gap junction degradation", "Formation of annular gap junctions", "Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "HATs acetylate histones", "Prefoldin mediated transfer of substrate to CCT/TriC", "Folding of actin by CCT/TriC", "EPHB-mediated forward signaling", "EPH-ephrin mediated repulsion of cells", "Adherens junctions interactions", "Adherens junctions interactions", "Recycling pathway of L1", "Recycling pathway of L1", "VEGFA-VEGFR2 Pathway", "Interaction between L1 and Ankyrins", "Interaction between L1 and Ankyrins", "Cell-extracellular matrix interactions", "B-WICH complex positively regulates rRNA expression", "RHO GTPases activate IQGAPs", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate Formins", "RHO GTPases Activate Formins", "MAP2K and MAPK activation", "UCH proteinases", "DNA Damage Recognition in GG-NER", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF", "Clathrin-mediated endocytosis", "Factors involved in megakaryocyte development and platelet production"], "P60763": ["Rho GTPase cycle", "PCP/CE pathway"], "P60842": ["ISG15 antiviral mechanism", "L13a-mediated translational silencing of Ceruloplasmin expression", "Deadenylation of mRNA", "Translation initiation complex formation", "Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "P60852": ["Interaction With The Zona Pellucida"], "P60866": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P60880": ["Serotonin Neurotransmitter Release Cycle", "Norepinephrine Neurotransmitter Release Cycle", "Glutamate Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle", "Acetylcholine Neurotransmitter Release Cycle", "Regulation of insulin secretion", "Other interleukin signaling", "Toxicity of botulinum toxin type A (BoNT/A)", "Toxicity of botulinum toxin type C (BoNT/C)", "Toxicity of botulinum toxin type E (BoNT/E)", "Neutrophil degranulation", "GABA synthesis, release, reuptake and degradation"], "P60891": ["5-Phosphoribose 1-diphosphate biosynthesis"], "P60896": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "P60900": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "P60903": ["Dissolution of Fibrin Clot"], "P60953": ["GPVI-mediated activation cascade", "EGFR downregulation", "Rho GTPase cycle", "Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "CDO in myogenesis", "CDO in myogenesis", "CD28 dependent Vav1 pathway", "EPHB-mediated forward signaling", "EPHB-mediated forward signaling", "DCC mediated attractive signaling", "Inactivation of CDC42 and RAC1", "VEGFA-VEGFR2 Pathway", "RHO GTPases activate KTN1", "RHO GTPases activate IQGAPs", "RHO GTPases activate PAKs", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate Formins", "RHO GTPases Activate Formins", "MAPK6/MAPK4 signaling", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "G beta:gamma signalling through CDC42", "Factors involved in megakaryocyte development and platelet production"], "P61006": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Regulation of PLK1 Activity at G2/M Transition", "Anchoring of the basal body to the plasma membrane", "VxPx cargo-targeting to cilium", "TBC/RABGAPs", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "P61009": ["SRP-dependent cotranslational protein targeting to membrane", "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)", "Synthesis, secretion, and deacylation of Ghrelin"], "P61011": ["SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane"], "P61018": ["Neutrophil degranulation", "RAB geranylgeranylation", "MET receptor recycling"], "P61019": ["Golgi Cisternae Pericentriolar Stack Reorganization", "RAB geranylgeranylation"], "P61020": ["Neutrophil degranulation", "TBC/RABGAPs", "Clathrin-mediated endocytosis", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "P61024": ["SCF(Skp2)-mediated degradation of p27/p21", "Cyclin D associated events in G1"], "P61026": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Neutrophil degranulation", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "P61073": ["Binding and entry of HIV virion", "Signaling by ROBO receptors", "Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "P61077": ["Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "TICAM1, RIP1-mediated IKK complex recruitment ", "Signaling by BMP", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "E3 ubiquitin ligases ubiquitinate target proteins", "Neddylation", "Peroxisomal protein import", "Negative regulators of DDX58/IFIH1 signaling", "IKK complex recruitment mediated by RIP1", "Antigen processing: Ubiquitination & Proteasome degradation"], "P61081": ["TGF-beta receptor signaling activates SMADs", "Dectin-1 mediated noncanonical NF-kB signaling", "NIK-->noncanonical NF-kB signaling", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "P61086": ["Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Negative regulators of DDX58/IFIH1 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "P61088": ["ISG15 antiviral mechanism", "NOD1/2 Signaling Pathway", "TICAM1, RIP1-mediated IKK complex recruitment ", "Downstream TCR signaling", "FCERI mediated NF-kB activation", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "activated TAK1 mediates p38 MAPK activation", "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "CLEC7A (Dectin-1) signaling", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "Formation of Incision Complex in GG-NER", "G2/M DNA damage checkpoint", "E3 ubiquitin ligases ubiquitinate target proteins", "Interleukin-1 signaling", "IRAK1 recruits IKK complex", "IKK complex recruitment mediated by RIP1", "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "Antigen processing: Ubiquitination & Proteasome degradation"], "P61106": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Synthesis of PIPs at the plasma membrane", "Neutrophil degranulation", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "P61158": ["Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "EPHB-mediated forward signaling", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs", "Clathrin-mediated endocytosis"], "P61160": ["Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "EPHB-mediated forward signaling", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs", "Neutrophil degranulation", "Clathrin-mediated endocytosis"], "P61163": ["MHC class II antigen presentation", "Regulation of PLK1 Activity at G2/M Transition", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic", "AURKA Activation by TPX2"], "P61201": ["DNA Damage Recognition in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Cargo recognition for clathrin-mediated endocytosis", "Neddylation"], "P61204": ["Synthesis of PIPs at the Golgi membrane", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "P61218": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Abortive elongation of HIV-1 transcript in the absence of Tat", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "Viral Messenger RNA Synthesis", "Cytosolic sensors of pathogen-associated DNA ", "MicroRNA (miRNA) biogenesis", "NoRC negatively regulates rRNA expression", "Transcriptional regulation of pluripotent stem cells", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "PIWI-interacting RNA (piRNA) biogenesis", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase III Chain Elongation", "RNA Polymerase I Transcription Termination", "RNA Polymerase III Transcription Termination", "RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Pol II CTD phosphorylation and interaction with CE", "Signaling by FGFR2 IIIa TM", "Estrogen-dependent gene expression"], "P61221": ["OAS antiviral response", "Interferon alpha/beta signaling"], "P61224": ["Integrin alphaIIb beta3 signaling", "GRB2:SOS provides linkage to MAPK signaling for Integrins ", "p130Cas linkage to MAPK signaling for integrins", "Rap1 signalling", "MAP2K and MAPK activation", "Neutrophil degranulation", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF", "MET activates RAP1 and RAC1", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "P61225": ["Neutrophil degranulation"], "P61244": ["Transcription of E2F targets under negative control by DREAM complex", "Cyclin E associated events during G1/S transition ", "Cyclin A:Cdk2-associated events at S phase entry", "Transcriptional Regulation by E2F6"], "P61247": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P61254": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P61266": ["Toxicity of botulinum toxin type C (BoNT/C)", "LGI-ADAM interactions"], "P61278": ["Peptide ligand-binding receptors", "G alpha (i) signalling events", "MECP2 regulates transcription of neuronal ligands"], "P61289": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "P61296": ["Transcriptional regulation by RUNX2"], "P61313": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P61326": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P61328": ["Phase 0 - rapid depolarisation"], "P61353": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P61371": ["Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)", "Regulation of expression of SLITs and ROBOs"], "P61421": ["ROS, RNS production in phagocytes", "XBP1(S) activates chaperone genes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "P61457": ["Phenylalanine and tyrosine catabolism"], "P61513": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P61586": ["GPVI-mediated activation cascade", "Axonal growth inhibition (RHOA activation)", "Rho GTPase cycle", "PI3K/AKT activation", "Axonal growth stimulation", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "G beta:gamma signalling through PI3Kgamma", "EPHB-mediated forward signaling", "EPHB-mediated forward signaling", "EPHA-mediated growth cone collapse", "EPHA-mediated growth cone collapse", "PCP/CE pathway", "G alpha (12/13) signalling events", "Sema4D mediated inhibition of cell attachment and migration", "Sema4D induced cell migration and growth-cone collapse", "Sema4D induced cell migration and growth-cone collapse", "VEGFA-VEGFR2 Pathway", "RHO GTPases activate PKNs", "RHO GTPases activate CIT", "RHO GTPases activate CIT", "RHO GTPases activate KTN1", "RHO GTPases Activate ROCKs", "RHO GTPases Activate ROCKs", "RHO GTPases Activate Formins", "RHO GTPases Activate Rhotekin and Rhophilins", "RHO GTPases Activate Rhotekin and Rhophilins", "Ovarian tumor domain proteases", "ERBB2 Regulates Cell Motility", "Neutrophil degranulation", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "SLIT2:ROBO1 increases RHOA activity"], "P61601": ["Activation of Ca-permeable Kainate Receptor"], "P61619": ["ER-Phagosome pathway", "SRP-dependent cotranslational protein targeting to membrane", "XBP1(S) activates chaperone genes"], "P61626": ["Neutrophil degranulation", "Antimicrobial peptides", "Amyloid fiber formation"], "P61647": ["Sialic acid metabolism", "N-Glycan antennae elongation"], "P61758": ["Prefoldin mediated transfer of substrate to CCT/TriC"], "P61764": ["Regulation of insulin secretion", "Neurexins and neuroligins"], "P61764-1": ["Serotonin Neurotransmitter Release Cycle", "Norepinephrine Neurotransmitter Release Cycle", "Glutamate Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle", "Acetylcholine Neurotransmitter Release Cycle", "GABA synthesis, release, reuptake and degradation"], "P61769": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Nef mediated downregulation of MHC class I complex cell surface expression", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "DAP12 interactions", "DAP12 signaling", "DAP12 signaling", "Neutrophil degranulation", "Interferon gamma signaling", "Amyloid fiber formation", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "P61803": ["Asparagine N-linked glycosylation"], "P61812": ["Platelet degranulation ", "Molecules associated with elastic fibres", "ECM proteoglycans"], "P61916": ["Neutrophil degranulation", "LDL clearance"], "P61923": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "P61927": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P61952": ["Glucagon signaling in metabolic regulation", "G-protein activation", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42"], "P61956": ["Vitamin D (calciferol) metabolism", "SUMO is conjugated to E1 (UBA2:SAE1)", "SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "SUMO is proteolytically processed", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of transcription factors", "SUMOylation of transcription cofactors", "SUMOylation of SUMOylation proteins", "SUMOylation of intracellular receptors", "SUMOylation of intracellular receptors", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "Processing of DNA double-strand break ends", "Formation of Incision Complex in GG-NER"], "P61962": ["Association of TriC/CCT with target proteins during biosynthesis", "Neddylation"], "P61964": ["PKMTs methylate histone lysines", "HATs acetylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Neddylation"], "P61966": ["Nef mediated downregulation of MHC class I complex cell surface expression", "MHC class II antigen presentation", "Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis"], "P61978": ["SUMOylation of RNA binding proteins", "mRNA Splicing - Major Pathway", "Processing of Capped Intron-Containing Pre-mRNA"], "P61981": ["Activation of BAD and translocation to mitochondria ", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "RHO GTPases activate PKNs", "TP53 Regulates Metabolic Genes", "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "AURKA Activation by TPX2", "Regulation of localization of FOXO transcription factors"], "P62072": ["Mitochondrial protein import", "Mitochondrial protein import"], "P62079": ["Amyloid fiber formation"], "P62081": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P62136": ["Triglyceride catabolism", "DARPP-32 events", "Downregulation of TGF-beta receptor signaling", "Circadian Clock"], "P62140": ["Triglyceride catabolism", "Downregulation of TGF-beta receptor signaling", "Regulation of PLK1 Activity at G2/M Transition", "Circadian Clock", "RHO GTPases activate PKNs", "RHO GTPases activate PKNs", "RHO GTPases activate CIT", "RHO GTPases Activate ROCKs", "RHO GTPases activate PAKs", "RHO GTPases activate PAKs"], "P62191": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "P62195": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "P62241": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P62244": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P62249": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P62253": ["Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Antigen processing: Ubiquitination & Proteasome degradation"], "P62256": ["Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Antigen processing: Ubiquitination & Proteasome degradation"], "P62258": ["Activation of BAD and translocation to mitochondria ", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Signaling by Hippo", "NADE modulates death signalling", "Regulation of PLK1 Activity at G2/M Transition", "Regulation of HSF1-mediated heat shock response", "HSF1 activation", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "RHO GTPases activate PKNs", "TP53 Regulates Metabolic Genes", "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "AURKA Activation by TPX2", "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "RAB GEFs exchange GTP for GDP on RABs"], "P62263": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P62266": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P62269": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P62273": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P62277": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P62280": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P62304": ["Cleavage of Growing Transcript in the Termination Region ", "SLBP independent Processing of Histone Pre-mRNAs", "snRNP Assembly", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"], "P62306": ["Cleavage of Growing Transcript in the Termination Region ", "SLBP independent Processing of Histone Pre-mRNAs", "snRNP Assembly", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"], "P62308": ["Cleavage of Growing Transcript in the Termination Region ", "SLBP independent Processing of Histone Pre-mRNAs", "snRNP Assembly", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"], "P62310": ["mRNA decay by 5' to 3' exoribonuclease", "mRNA decay by 5' to 3' exoribonuclease", "mRNA Splicing - Major Pathway"], "P62312": ["mRNA decay by 5' to 3' exoribonuclease", "mRNA decay by 5' to 3' exoribonuclease", "mRNA Splicing - Major Pathway"], "P62314": ["snRNP Assembly", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "P62316": ["snRNP Assembly", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "P62318": ["Cleavage of Growing Transcript in the Termination Region ", "SLBP independent Processing of Histone Pre-mRNAs", "snRNP Assembly", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"], "P62324": ["FOXO-mediated transcription of cell cycle genes"], "P62328": ["Platelet degranulation "], "P62330": ["TBC/RABGAPs", "Clathrin-mediated endocytosis", "MET receptor recycling"], "P62333": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "P62424": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P62487": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Abortive elongation of HIV-1 transcript in the absence of Tat", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "Viral Messenger RNA Synthesis", "MicroRNA (miRNA) biogenesis", "Transcriptional regulation of pluripotent stem cells", "Transcriptional regulation by small RNAs", "PIWI-interacting RNA (piRNA) biogenesis", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE", "Signaling by FGFR2 IIIa TM", "Estrogen-dependent gene expression"], "P62491": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Vasopressin regulates renal water homeostasis via Aquaporins", "Anchoring of the basal body to the plasma membrane", "VxPx cargo-targeting to cilium", "TBC/RABGAPs", "RAB geranylgeranylation"], "P62495": ["Eukaryotic Translation Termination", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P62508": ["Nuclear Receptor transcription pathway"], "P62699": ["Neutrophil degranulation"], "P62701": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P62714": ["Inhibition of replication initiation of damaged DNA by RB1/E2F1", "Spry regulation of FGF signaling", "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Integration of energy metabolism", "PP2A-mediated dephosphorylation of key metabolic factors", "DARPP-32 events", "Degradation of beta-catenin by the destruction complex", "Beta-catenin phosphorylation cascade", "ERK/MAPK targets", "ERKs are inactivated", "MASTL Facilitates Mitotic Progression", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "CTLA4 inhibitory signaling", "Platelet sensitization by LDL", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Misspliced GSK3beta mutants stabilize beta-catenin", "S33 mutants of beta-catenin aren't phosphorylated", "S37 mutants of beta-catenin aren't phosphorylated", "S45 mutants of beta-catenin aren't phosphorylated", "T41 mutants of beta-catenin aren't phosphorylated", "APC truncation mutants have impaired AXIN binding", "AXIN missense mutants destabilize the destruction complex", "Truncations of AMER1 destabilize the destruction complex", "RHO GTPases Activate Formins", "RAF activation", "Negative regulation of MAPK pathway", "Regulation of TP53 Degradation", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Mitotic Prometaphase", "Cyclin D associated events in G1", "Cyclin A/B1/B2 associated events during G2/M transition", "Glycolysis"], "P62736": ["Smooth Muscle Contraction", "NOTCH4 Intracellular Domain Regulates Transcription"], "P62745": ["GPVI-mediated activation cascade", "Rho GTPase cycle", "G alpha (12/13) signalling events", "Sema4D induced cell migration and growth-cone collapse", "Sema4D induced cell migration and growth-cone collapse", "RHO GTPases activate PKNs", "RHO GTPases activate CIT", "RHO GTPases activate CIT", "RHO GTPases Activate ROCKs", "RHO GTPases Activate ROCKs", "RHO GTPases Activate Formins", "RHO GTPases Activate Rhotekin and Rhophilins"], "P62750": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P62753": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "mTORC1-mediated signalling", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P62805": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "SUMOylation of chromatin organization proteins", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "P62807": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "HATs acetylate histones", "HATs acetylate histones", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Ub-specific processing proteases", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "E3 ubiquitin ligases ubiquitinate target proteins", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "P62820": ["Golgi Cisternae Pericentriolar Stack Reorganization", "Golgi Cisternae Pericentriolar Stack Reorganization", "COPII-mediated vesicle transport", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "P62826": ["Rev-mediated nuclear export of HIV RNA", "Regulation of cholesterol biosynthesis by SREBP (SREBF)", "NEP/NS2 Interacts with the Cellular Export Machinery", "Nuclear import of Rev protein", "MicroRNA (miRNA) biogenesis", "Transcriptional regulation by small RNAs", "tRNA processing in the nucleus"], "P62829": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P62834": ["Frs2-mediated activation", "ARMS-mediated activation", "ARMS-mediated activation", "Integrin alphaIIb beta3 signaling", "GRB2:SOS provides linkage to MAPK signaling for Integrins ", "p130Cas linkage to MAPK signaling for integrins", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Rap1 signalling", "MAP2K and MAPK activation", "Neutrophil degranulation", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF", "MET activates RAP1 and RAC1"], "P62837": ["Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "TICAM1, RIP1-mediated IKK complex recruitment ", "Downstream TCR signaling", "FCERI mediated NF-kB activation", "CLEC7A (Dectin-1) signaling", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "E3 ubiquitin ligases ubiquitinate target proteins", "Neddylation", "Peroxisomal protein import", "Negative regulators of DDX58/IFIH1 signaling", "IKK complex recruitment mediated by RIP1", "Antigen processing: Ubiquitination & Proteasome degradation"], "P62841": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P62847": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P62851": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P62854": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P62857": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P62861": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P62873": ["Activation of G protein gated Potassium channels", "Glucagon signaling in metabolic regulation", "G-protein activation", "Activation of the phototransduction cascade", "Activation of the phototransduction cascade", "Inactivation, recovery and regulation of the phototransduction cascade", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Olfactory Signaling Pathway", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42", "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "P62875": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Abortive elongation of HIV-1 transcript in the absence of Tat", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "Viral Messenger RNA Synthesis", "Cytosolic sensors of pathogen-associated DNA ", "MicroRNA (miRNA) biogenesis", "NoRC negatively regulates rRNA expression", "Transcriptional regulation of pluripotent stem cells", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "PIWI-interacting RNA (piRNA) biogenesis", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase III Chain Elongation", "RNA Polymerase I Transcription Termination", "RNA Polymerase III Transcription Termination", "RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Pol II CTD phosphorylation and interaction with CE", "Signaling by FGFR2 IIIa TM", "Estrogen-dependent gene expression"], "P62877": ["Recognition of DNA damage by PCNA-containing replication complex", "Prolactin receptor signaling", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Vif-mediated degradation of APOBEC3G", "Degradation of beta-catenin by the destruction complex", "NOTCH1 Intracellular Domain Regulates Transcription", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "Degradation of DVL", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "DNA Damage Recognition in GG-NER", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Orc1 removal from chromatin", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "P62879": ["Activation of G protein gated Potassium channels", "Glucagon signaling in metabolic regulation", "G-protein activation", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42", "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "P62888": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P62891": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P62899": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P62906": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P62910": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P62913": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P62917": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P62937": ["Platelet degranulation ", "Uncoating of the HIV Virion", "Budding and maturation of HIV virion", "Integration of provirus", "Early Phase of HIV Life Cycle", "Minus-strand DNA synthesis", "Plus-strand DNA synthesis", "Binding and entry of HIV virion", "Assembly Of The HIV Virion", "APOBEC3G mediated resistance to HIV-1 infection", "Calcineurin activates NFAT", "Basigin interactions", "Neutrophil degranulation", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "P62942": ["Calcineurin activates NFAT", "TGF-beta receptor signaling activates SMADs", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "TGFBR2 Kinase Domain Mutants in Cancer", "TGFBR1 KD Mutants in Cancer", "TGFBR1 LBD Mutants in Cancer"], "P62945": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P62955": ["Phase 0 - rapid depolarisation", "Phase 2 - plateau phase"], "P62979": ["Translesion synthesis by REV1", "Recognition of DNA damage by PCNA-containing replication complex", "Translesion Synthesis by POLH", "Activation of NF-kappaB in B cells", "ISG15 antiviral mechanism", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "ER-Phagosome pathway", "Downregulation of ERBB4 signaling", "Spry regulation of FGF signaling", "Downregulation of ERBB2:ERBB3 signaling", "L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "Budding and maturation of HIV virion", "NOD1/2 Signaling Pathway", "TICAM1, RIP1-mediated IKK complex recruitment ", "DDX58/IFIH1-mediated induction of interferon-alpha/beta", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Membrane binding and targetting of GAG proteins", "Assembly Of The HIV Virion", "APC-Cdc20 mediated degradation of Nek2A", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "EGFR downregulation", "SCF(Skp2)-mediated degradation of p27/p21", "Viral mRNA Translation", "Degradation of beta-catenin by the destruction complex", "TCF dependent signaling in response to WNT", "Downstream TCR signaling", "NRIF signals cell death from the nucleus", "p75NTR recruits signalling complexes", "NF-kB is activated and signals survival", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "NOTCH1 Intracellular Domain Regulates Transcription", "Activated NOTCH1 Transmits Signal to the Nucleus", "Activated NOTCH1 Transmits Signal to the Nucleus", "Downregulation of TGF-beta receptor signaling", "Downregulation of TGF-beta receptor signaling", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Selenocysteine synthesis", "Separation of Sister Chromatids", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "Oncogene Induced Senescence", "Regulation of PLK1 Activity at G2/M Transition", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Stimuli-sensing channels", "Constitutive Signaling by NOTCH1 HD Domain Mutants", "FCERI mediated NF-kB activation", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "NOTCH2 Activation and Transmission of Signal to the Nucleus", "Regulation of innate immune responses to cytosolic DNA", "Glycogen synthesis", "Autodegradation of the E3 ubiquitin ligase COP1", "Deactivation of the beta-catenin transactivating complex", "Myoclonic epilepsy of Lafora", "ABC-family proteins mediated transport", "Circadian Clock", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "activated TAK1 mediates p38 MAPK activation", "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Regulation of FZD by ubiquitination", "Pink/Parkin Mediated Mitophagy", "N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Hedgehog 'on' state", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "Translesion synthesis by POLK", "Translesion synthesis by POLI", "Termination of translesion DNA synthesis", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "Negative regulation of MAPK pathway", "Regulation of necroptotic cell death", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAP3K8 (TPL2)-dependent MAPK1/3 activation", "HDR through Homologous Recombination (HRR)", "MAPK6/MAPK4 signaling", "UCH proteinases", "UCH proteinases", "Josephin domain DUBs", "Ub-specific processing proteases", "Ovarian tumor domain proteases", "Metalloprotease DUBs", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Processing of DNA double-strand break ends", "DNA Damage Recognition in GG-NER", "Formation of Incision Complex in GG-NER", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Fanconi Anemia Pathway", "Major pathway of rRNA processing in the nucleolus and cytosol", "Regulation of TP53 Activity through Phosphorylation", "Regulation of TP53 Degradation", "Regulation of TP53 Activity through Methylation", "Negative regulation of MET activity", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "Cyclin D associated events in G1", "G2/M Checkpoints", "Stabilization of p53", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "Downregulation of ERBB2 signaling", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "E3 ubiquitin ligases ubiquitinate target proteins", "InlB-mediated entry of Listeria monocytogenes into host cell", "InlA-mediated entry of Listeria monocytogenes into host cells", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN localization", "Regulation of PTEN stability and activity", "Neddylation", "ER Quality Control Compartment (ERQC)", "Regulation of expression of SLITs and ROBOs", "Regulation of expression of SLITs and ROBOs", "NOTCH3 Activation and Transmission of Signal to the Nucleus", "NOTCH3 Activation and Transmission of Signal to the Nucleus", "TICAM1-dependent activation of IRF3/IRF7", "TICAM1,TRAF6-dependent induction of TAK1 complex", "Interleukin-1 signaling", "Peroxisomal protein import", "Peroxisomal protein import", "Regulation of signaling by CBL", "Endosomal Sorting Complex Required For Transport (ESCRT)", "Iron uptake and transport", "Negative regulators of DDX58/IFIH1 signaling", "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon", "IRAK1 recruits IKK complex", "IKK complex recruitment mediated by RIP1", "IRAK2 mediated activation of TAK1 complex", "TRAF6-mediated induction of TAK1 complex within TLR4 complex", "Negative regulation of NOTCH4 signaling", "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "Amyloid fiber formation", "Antigen processing: Ubiquitination & Proteasome degradation"], "P62987": ["Translesion synthesis by REV1", "Recognition of DNA damage by PCNA-containing replication complex", "Translesion Synthesis by POLH", "Activation of NF-kappaB in B cells", "ISG15 antiviral mechanism", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "ER-Phagosome pathway", "Downregulation of ERBB4 signaling", "Spry regulation of FGF signaling", "Downregulation of ERBB2:ERBB3 signaling", "L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "Budding and maturation of HIV virion", "NOD1/2 Signaling Pathway", "TICAM1, RIP1-mediated IKK complex recruitment ", "DDX58/IFIH1-mediated induction of interferon-alpha/beta", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Membrane binding and targetting of GAG proteins", "Assembly Of The HIV Virion", "APC-Cdc20 mediated degradation of Nek2A", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "EGFR downregulation", "SCF(Skp2)-mediated degradation of p27/p21", "Viral mRNA Translation", "Degradation of beta-catenin by the destruction complex", "TCF dependent signaling in response to WNT", "Downstream TCR signaling", "NRIF signals cell death from the nucleus", "p75NTR recruits signalling complexes", "NF-kB is activated and signals survival", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "NOTCH1 Intracellular Domain Regulates Transcription", "Activated NOTCH1 Transmits Signal to the Nucleus", "Activated NOTCH1 Transmits Signal to the Nucleus", "Downregulation of TGF-beta receptor signaling", "Downregulation of TGF-beta receptor signaling", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Selenocysteine synthesis", "Separation of Sister Chromatids", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "Oncogene Induced Senescence", "Regulation of PLK1 Activity at G2/M Transition", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Stimuli-sensing channels", "Constitutive Signaling by NOTCH1 HD Domain Mutants", "FCERI mediated NF-kB activation", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "NOTCH2 Activation and Transmission of Signal to the Nucleus", "Regulation of innate immune responses to cytosolic DNA", "Glycogen synthesis", "Autodegradation of the E3 ubiquitin ligase COP1", "Deactivation of the beta-catenin transactivating complex", "Myoclonic epilepsy of Lafora", "ABC-family proteins mediated transport", "Circadian Clock", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "activated TAK1 mediates p38 MAPK activation", "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Regulation of FZD by ubiquitination", "Pink/Parkin Mediated Mitophagy", "N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Hedgehog 'on' state", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "Translesion synthesis by POLK", "Translesion synthesis by POLI", "Termination of translesion DNA synthesis", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "Negative regulation of MAPK pathway", "Regulation of necroptotic cell death", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAP3K8 (TPL2)-dependent MAPK1/3 activation", "HDR through Homologous Recombination (HRR)", "MAPK6/MAPK4 signaling", "UCH proteinases", "UCH proteinases", "Josephin domain DUBs", "Ub-specific processing proteases", "Ovarian tumor domain proteases", "Metalloprotease DUBs", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Processing of DNA double-strand break ends", "DNA Damage Recognition in GG-NER", "Formation of Incision Complex in GG-NER", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Fanconi Anemia Pathway", "Major pathway of rRNA processing in the nucleolus and cytosol", "Regulation of TP53 Activity through Phosphorylation", "Regulation of TP53 Degradation", "Regulation of TP53 Activity through Methylation", "Negative regulation of MET activity", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "Cyclin D associated events in G1", "G2/M Checkpoints", "Stabilization of p53", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "Downregulation of ERBB2 signaling", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "E3 ubiquitin ligases ubiquitinate target proteins", "InlB-mediated entry of Listeria monocytogenes into host cell", "InlA-mediated entry of Listeria monocytogenes into host cells", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN localization", "Regulation of PTEN stability and activity", "Neddylation", "ER Quality Control Compartment (ERQC)", "Regulation of expression of SLITs and ROBOs", "Regulation of expression of SLITs and ROBOs", "NOTCH3 Activation and Transmission of Signal to the Nucleus", "NOTCH3 Activation and Transmission of Signal to the Nucleus", "TICAM1-dependent activation of IRF3/IRF7", "TICAM1,TRAF6-dependent induction of TAK1 complex", "Interleukin-1 signaling", "Peroxisomal protein import", "Peroxisomal protein import", "Regulation of signaling by CBL", "Endosomal Sorting Complex Required For Transport (ESCRT)", "Iron uptake and transport", "Negative regulators of DDX58/IFIH1 signaling", "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon", "IRAK1 recruits IKK complex", "IKK complex recruitment mediated by RIP1", "IRAK2 mediated activation of TAK1 complex", "TRAF6-mediated induction of TAK1 complex within TLR4 complex", "Negative regulation of NOTCH4 signaling", "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "Amyloid fiber formation", "Antigen processing: Ubiquitination & Proteasome degradation"], "P62993": ["Interleukin-15 signaling", "Interleukin-15 signaling"], "P62993-1": ["PI3K Cascade", "SOS-mediated signalling", "SOS-mediated signalling", "Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "SHC1 events in ERBB2 signaling", "SHC1 events in ERBB4 signaling", "PIP3 activates AKT signaling", "Spry regulation of FGF signaling", "Signaling by SCF-KIT", "Regulation of KIT signaling", "Signalling to RAS", "Signalling to RAS", "GRB2 events in EGFR signaling", "GAB1 signalosome", "SHC1 events in EGFR signaling", "EGFR downregulation", "Signaling by cytosolic FGFR1 fusion mutants", "Downstream signal transduction", "GRB2 events in ERBB2 signaling", "GRB2 events in ERBB2 signaling", "PI3K events in ERBB2 signaling", "Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "Tie2 Signaling", "EGFR Transactivation by Gastrin", "Constitutive Signaling by Aberrant PI3K in Cancer", "DAP12 signaling", "SHC-related events triggered by IGF1R", "SHC-related events triggered by IGF1R", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "GRB2:SOS provides linkage to MAPK signaling for Integrins ", "NCAM signaling for neurite out-growth", "Costimulation by the CD28 family", "CD28 dependent Vav1 pathway", "Signal regulatory protein family interactions", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "Constitutive Signaling by EGFRvIII", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "PI-3K cascade:FGFR3", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "PI-3K cascade:FGFR4", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "Signaling by FGFR2 in disease", "Signaling by FGFR4 in disease", "Signaling by FGFR1 in disease", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs", "RAF/MAP kinase cascade", "Negative regulation of MET activity", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Signal attenuation", "Insulin receptor signalling cascade", "Insulin receptor signalling cascade", "MET activates RAS signaling", "MET activates PI3K/AKT signaling", "Signaling by FGFR3 fusions in cancer", "Signaling by FGFR3 point mutants in cancer", "RET signaling", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "MET activates PTPN11", "InlB-mediated entry of Listeria monocytogenes into host cell", "InlB-mediated entry of Listeria monocytogenes into host cell", "MET activates RAP1 and RAC1", "MET receptor recycling", "Activated NTRK2 signals through RAS", "Erythropoietin activates RAS", "Erythropoietin activates RAS", "Activated NTRK2 signals through PI3K", "Activated NTRK2 signals through FRS2 and FRS3", "Activated NTRK2 signals through FRS2 and FRS3", "Activated NTRK3 signals through RAS", "Interleukin receptor SHC signaling", "Regulation of signaling by CBL", "Regulation of signaling by CBL", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P62995": ["mRNA Splicing - Major Pathway"], "P63000": ["GPVI-mediated activation cascade", "PIP3 activates AKT signaling", "Signaling by SCF-KIT", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Nef and signal transduction", "NRAGE signals death through JNK", "Rho GTPase cycle", "Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "Constitutive Signaling by Aberrant PI3K in Cancer", "DAP12 signaling", "FCERI mediated MAPK activation", "DSCAM interactions", "CD28 dependent Vav1 pathway", "EPHB-mediated forward signaling", "Ephrin signaling", "EPH-ephrin mediated repulsion of cells", "Sema3A PAK dependent Axon repulsion", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "PCP/CE pathway", "Sema4D mediated inhibition of cell attachment and migration", "DCC mediated attractive signaling", "DCC mediated attractive signaling", "Activation of RAC1", "Inactivation of CDC42 and RAC1", "VEGFA-VEGFR2 Pathway", "Signal transduction by L1", "VEGFR2 mediated vascular permeability", "RHO GTPases activate PKNs", "RHO GTPases activate CIT", "RHO GTPases activate CIT", "RHO GTPases activate KTN1", "RHO GTPases activate IQGAPs", "RHO GTPases activate PAKs", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate Formins", "RHO GTPases Activate Formins", "RHO GTPases Activate NADPH Oxidases", "MAPK6/MAPK4 signaling", "Neutrophil degranulation", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "MET activates RAP1 and RAC1", "NTRK2 activates RAC1", "Activated NTRK2 signals through CDK5", "Activation of RAC1 downstream of NMDARs", "Factors involved in megakaryocyte development and platelet production"], "P63010": ["Nef Mediated CD4 Down-regulation", "Retrograde neurotrophin signalling", "Retrograde neurotrophin signalling", "Nef Mediated CD8 Down-regulation", "MHC class II antigen presentation", "EPH-ephrin mediated repulsion of cells", "Recycling pathway of L1", "Recycling pathway of L1", "WNT5A-dependent internalization of FZD4", "WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "VLDLR internalisation and degradation", "LDL clearance"], "P63010-1": ["Trafficking of GluR2-containing AMPA receptors"], "P63027": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Serotonin Neurotransmitter Release Cycle", "Norepinephrine Neurotransmitter Release Cycle", "Glutamate Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle", "Acetylcholine Neurotransmitter Release Cycle", "Insulin processing", "Clathrin derived vesicle budding", "Regulation of insulin secretion", "Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis", "Other interleukin signaling", "Toxicity of botulinum toxin type D (BoNT/D)", "Toxicity of botulinum toxin type B (BoNT/B)", "Toxicity of botulinum toxin type F (BoNT/F)", "Toxicity of tetanus toxin (TeNT)", "Toxicity of botulinum toxin type G (BoNT/G)", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "GABA synthesis, release, reuptake and degradation"], "P63092": ["Glucagon signaling in metabolic regulation", "PKA activation in glucagon signalling", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Prostacyclin signalling through prostacyclin receptor", "Prostacyclin signalling through prostacyclin receptor", "G alpha (s) signalling events", "G alpha (s) signalling events", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Vasopressin regulates renal water homeostasis via Aquaporins", "Hedgehog 'off' state"], "P63096": ["PLC beta mediated events", "PLC beta mediated events", "Adenylate cyclase inhibitory pathway", "Adenylate cyclase inhibitory pathway", "G-protein activation", "ADP signalling through P2Y purinoceptor 12", "Adrenaline,noradrenaline inhibits insulin secretion", "Adrenaline,noradrenaline inhibits insulin secretion", "G alpha (s) signalling events", "G alpha (i) signalling events", "G alpha (i) signalling events", "G alpha (z) signalling events", "Regulation of insulin secretion", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "P63098": ["Activation of BAD and translocation to mitochondria ", "DARPP-32 events", "Calcineurin activates NFAT", "Calcineurin activates NFAT", "FCERI mediated Ca+2 mobilization", "Ca2+ pathway", "CLEC7A (Dectin-1) induces NFAT activation"], "P63104": ["Activation of BAD and translocation to mitochondria ", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Deactivation of the beta-catenin transactivating complex", "Rap1 signalling", "GP1b-IX-V activation signalling", "KSRP (KHSRP) binds and destabilizes mRNA", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "RHO GTPases activate PKNs", "TP53 Regulates Metabolic Genes", "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "NOTCH4 Activation and Transmission of Signal to the Nucleus", "Negative regulation of NOTCH4 signaling", "Regulation of localization of FOXO transcription factors"], "P63146": ["Recognition of DNA damage by PCNA-containing replication complex", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "E3 ubiquitin ligases ubiquitinate target proteins", "Antigen processing: Ubiquitination & Proteasome degradation"], "P63151": ["Initiation of Nuclear Envelope Reformation", "Cyclin D associated events in G1", "Cyclin A/B1/B2 associated events during G2/M transition", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P63162": ["mRNA Splicing - Major Pathway"], "P63165": ["SUMO is conjugated to E1 (UBA2:SAE1)", "SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "SUMO is proteolytically processed", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of transcription factors", "SUMOylation of transcription factors", "SUMOylation of ubiquitinylation proteins", "SUMOylation of transcription cofactors", "SUMOylation of transcription cofactors", "SUMOylation of SUMOylation proteins", "SUMOylation of intracellular receptors", "SUMOylation of intracellular receptors", "SUMOylation of chromatin organization proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA methylation proteins", "SUMOylation of DNA methylation proteins", "SUMOylation of immune response proteins", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "Formation of Incision Complex in GG-NER", "G2/M DNA damage checkpoint", "Regulation of IFNG signaling", "Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "Negative regulation of activity of TFAP2 (AP-2) family transcription factors"], "P63167": ["Activation of BIM and translocation to mitochondria ", "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Macroautophagy", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Regulation of PLK1 Activity at G2/M Transition", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "Intraflagellar transport", "RHO GTPases Activate Formins", "Neutrophil degranulation", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "AURKA Activation by TPX2"], "P63172": ["Neutrophil degranulation"], "P63173": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P63208": ["Activation of NF-kappaB in B cells", "Prolactin receptor signaling", "SCF-beta-TrCP mediated degradation of Emi1", "Vpu mediated degradation of CD4", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "NOTCH1 Intracellular Domain Regulates Transcription", "Regulation of PLK1 Activity at G2/M Transition", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling", "FCERI mediated NF-kB activation", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "Circadian Clock", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "NIK-->noncanonical NF-kB signaling", "MAP3K8 (TPL2)-dependent MAPK1/3 activation", "Orc1 removal from chromatin", "Cyclin D associated events in G1", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Neddylation", "Interleukin-1 signaling", "Iron uptake and transport", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "P63211": ["Activation of G protein gated Potassium channels", "G-protein activation", "Activation of the phototransduction cascade", "Activation of the phototransduction cascade", "Inactivation, recovery and regulation of the phototransduction cascade", "Inactivation, recovery and regulation of the phototransduction cascade", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Olfactory Signaling Pathway", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42", "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "P63215": ["Activation of G protein gated Potassium channels", "Glucagon signaling in metabolic regulation", "G-protein activation", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42", "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "P63218": ["Activation of G protein gated Potassium channels", "Glucagon signaling in metabolic regulation", "G-protein activation", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42", "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "P63220": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P63241": ["Hypusine synthesis from eIF5A-lysine"], "P63244": ["Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "TNFR1-mediated ceramide production"], "P63252": ["Activation of G protein gated Potassium channels", "Classical Kir channels", "Phase 4 - resting membrane potential", "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "P63261": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Gap junction degradation", "Formation of annular gap junctions", "Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "EPHB-mediated forward signaling", "EPH-ephrin mediated repulsion of cells", "Adherens junctions interactions", "Adherens junctions interactions", "Recycling pathway of L1", "Recycling pathway of L1", "VEGFA-VEGFR2 Pathway", "Interaction between L1 and Ankyrins", "Interaction between L1 and Ankyrins", "Cell-extracellular matrix interactions", "RHO GTPases activate IQGAPs", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate Formins", "RHO GTPases Activate Formins", "MAP2K and MAPK activation", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF", "Clathrin-mediated endocytosis"], "P63267": ["Smooth Muscle Contraction"], "P63272": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Abortive elongation of HIV-1 transcript in the absence of Tat", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Transcription Elongation"], "P63279": ["Meiotic synapsis", "Vitamin D (calciferol) metabolism", "SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of transcription factors", "SUMOylation of transcription factors", "SUMOylation of ubiquitinylation proteins", "SUMOylation of transcription cofactors", "SUMOylation of transcription cofactors", "SUMOylation of SUMOylation proteins", "SUMOylation of intracellular receptors", "SUMOylation of intracellular receptors", "SUMOylation of chromatin organization proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA methylation proteins", "SUMOylation of DNA methylation proteins", "SUMOylation of immune response proteins", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Processing of DNA double-strand break ends", "Formation of Incision Complex in GG-NER", "Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "Negative regulation of activity of TFAP2 (AP-2) family transcription factors"], "P63316": ["Striated Muscle Contraction"], "P67775": ["Inhibition of replication initiation of damaged DNA by RB1/E2F1", "Spry regulation of FGF signaling", "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Integration of energy metabolism", "PP2A-mediated dephosphorylation of key metabolic factors", "DARPP-32 events", "Degradation of beta-catenin by the destruction complex", "Beta-catenin phosphorylation cascade", "ERK/MAPK targets", "ERKs are inactivated", "MASTL Facilitates Mitotic Progression", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Initiation of Nuclear Envelope Reformation", "CTLA4 inhibitory signaling", "Platelet sensitization by LDL", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Misspliced GSK3beta mutants stabilize beta-catenin", "S33 mutants of beta-catenin aren't phosphorylated", "S37 mutants of beta-catenin aren't phosphorylated", "S45 mutants of beta-catenin aren't phosphorylated", "T41 mutants of beta-catenin aren't phosphorylated", "APC truncation mutants have impaired AXIN binding", "AXIN missense mutants destabilize the destruction complex", "Truncations of AMER1 destabilize the destruction complex", "RHO GTPases Activate Formins", "RAF activation", "Negative regulation of MAPK pathway", "Regulation of TP53 Degradation", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Mitotic Prometaphase", "Cyclin D associated events in G1", "Cyclin A/B1/B2 associated events during G2/M transition", "Glycolysis", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P67809": ["mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "Noncanonical activation of NOTCH3"], "P67812": ["SRP-dependent cotranslational protein targeting to membrane", "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)", "Synthesis, secretion, and deacylation of Ghrelin"], "P67870": ["Synthesis of PC", "WNT mediated activation of DVL", "Condensation of Prometaphase Chromosomes", "Signal transduction by L1", "Neutrophil degranulation", "Regulation of TP53 Activity through Phosphorylation", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "Receptor Mediated Mitophagy", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Regulation of PTEN stability and activity"], "P67936": ["Striated Muscle Contraction", "Smooth Muscle Contraction"], "P68032": ["Striated Muscle Contraction"], "P68036": ["Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "E3 ubiquitin ligases ubiquitinate target proteins", "Antigen processing: Ubiquitination & Proteasome degradation"], "P68104": ["Eukaryotic Translation Elongation", "Eukaryotic Translation Elongation", "Peptide chain elongation", "HSF1 activation", "Neutrophil degranulation", "Protein methylation"], "P68106": ["Stimuli-sensing channels", "Ion homeostasis"], "P68133": ["Striated Muscle Contraction"], "P68363": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "Gap junction assembly", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Recruitment of NuMA to mitotic centrosomes", "Formation of tubulin folding intermediates by CCT/TriC", "Post-chaperonin tubulin folding pathway", "Recycling pathway of L1", "Recycling pathway of L1", "Hedgehog 'off' state", "Cilium Assembly", "Intraflagellar transport", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "Carboxyterminal post-translational modifications of tubulin", "Carboxyterminal post-translational modifications of tubulin", "Activation of AMPK downstream of NMDARs", "Kinesins"], "P68366": ["Platelet degranulation ", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "Gap junction assembly", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Regulation of PLK1 Activity at G2/M Transition", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Prefoldin mediated transfer of substrate to CCT/TriC", "Formation of tubulin folding intermediates by CCT/TriC", "Post-chaperonin tubulin folding pathway", "Recycling pathway of L1", "Recycling pathway of L1", "Hedgehog 'off' state", "Cilium Assembly", "Anchoring of the basal body to the plasma membrane", "Intraflagellar transport", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "AURKA Activation by TPX2", "Carboxyterminal post-translational modifications of tubulin", "Carboxyterminal post-translational modifications of tubulin", "Activation of AMPK downstream of NMDARs", "Kinesins"], "P68371": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "Gap junction assembly", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Regulation of PLK1 Activity at G2/M Transition", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Prefoldin mediated transfer of substrate to CCT/TriC", "Formation of tubulin folding intermediates by CCT/TriC", "Post-chaperonin tubulin folding pathway", "Recycling pathway of L1", "Recycling pathway of L1", "Hedgehog 'off' state", "Cilium Assembly", "Anchoring of the basal body to the plasma membrane", "Intraflagellar transport", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "Neutrophil degranulation", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "AURKA Activation by TPX2", "Carboxyterminal post-translational modifications of tubulin", "Carboxyterminal post-translational modifications of tubulin", "Activation of AMPK downstream of NMDARs", "Kinesins"], "P68400": ["Synthesis of PC", "WNT mediated activation of DVL", "Condensation of Prometaphase Chromosomes", "Signal transduction by L1", "Regulation of TP53 Activity through Phosphorylation", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "Receptor Mediated Mitophagy", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Regulation of PTEN stability and activity"], "P68402": ["Neutrophil degranulation", "COPI-independent Golgi-to-ER retrograde traffic"], "P68431": ["Interleukin-7 signaling", "Interleukin-7 signaling", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "HDACs deacetylate histones", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "Chromatin modifying enzymes", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation", "Factors involved in megakaryocyte development and platelet production"], "P68871": ["Erythrocytes take up carbon dioxide and release oxygen", "Erythrocytes take up oxygen and release carbon dioxide", "Scavenging of heme from plasma", "Neutrophil degranulation", "Factors involved in megakaryocyte development and platelet production"], "P69723": ["Uncoating of the HIV Virion", "Budding and maturation of HIV virion", "Integration of provirus", "Early Phase of HIV Life Cycle", "Minus-strand DNA synthesis", "Plus-strand DNA synthesis", "2-LTR circle formation", "Binding and entry of HIV virion", "Assembly Of The HIV Virion", "Integration of viral DNA into host genomic DNA", "Autointegration results in viral DNA circles", "Vif-mediated degradation of APOBEC3G", "APOBEC3G mediated resistance to HIV-1 infection", "Vpr-mediated nuclear import of PICs"], "P69726": ["Uncoating of the HIV Virion", "Budding and maturation of HIV virion", "Integration of provirus", "Early Phase of HIV Life Cycle", "Minus-strand DNA synthesis", "Plus-strand DNA synthesis", "2-LTR circle formation", "Binding and entry of HIV virion", "Assembly Of The HIV Virion", "Integration of viral DNA into host genomic DNA", "Autointegration results in viral DNA circles", "APOBEC3G mediated resistance to HIV-1 infection", "Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization", "Vpr-mediated nuclear import of PICs"], "P69891": ["Factors involved in megakaryocyte development and platelet production"], "P69892": ["Factors involved in megakaryocyte development and platelet production"], "P69905": ["Erythrocytes take up carbon dioxide and release oxygen", "Erythrocytes take up oxygen and release carbon dioxide", "Scavenging of heme from plasma"], "P71828": ["Tolerance by Mtb to nitric oxide produced by macrophages"], "P71971": ["Tolerance by Mtb to nitric oxide produced by macrophages"], "P78310": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall"], "P78316": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "P78317": ["Processing of DNA double-strand break ends", "Antigen processing: Ubiquitination & Proteasome degradation"], "P78324": ["Cell surface interactions at the vascular wall", "Signal regulatory protein family interactions", "Signal regulatory protein family interactions", "Neutrophil degranulation"], "P78325": ["Degradation of the extracellular matrix", "Neutrophil degranulation"], "P78329": ["Fatty acids", "Miscellaneous substrates", "Eicosanoids", "Synthesis of Leukotrienes (LT) and Eoxins (EX)", "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)"], "P78330": ["Serine biosynthesis"], "P78333": ["A tetrasaccharide linker sequence is required for GAG synthesis", "HS-GAG biosynthesis", "HS-GAG biosynthesis", "HS-GAG degradation", "Defective B4GALT7 causes EDS, progeroid type", "Defective B3GAT3 causes JDSSDHD", "Defective EXT2 causes exostoses 2", "Defective EXT1 causes exostoses 1, TRPS2 and CHDS", "Defective B3GALT6 causes EDSP2 and SEMDJL1", "Release of Hh-Np from the secreting cell", "Retinoid metabolism and transport"], "P78344": ["ISG15 antiviral mechanism"], "P78345": ["tRNA processing in the nucleus", "Major pathway of rRNA processing in the nucleolus and cytosol"], "P78346": ["tRNA processing in the nucleus", "Major pathway of rRNA processing in the nucleolus and cytosol"], "P78348": ["Stimuli-sensing channels"], "P78352": ["Trafficking of AMPA receptors", "Unblocking of NMDA receptors, glutamate binding and activation", "Unblocking of NMDA receptors, glutamate binding and activation", "Ras activation upon Ca2+ influx through NMDA receptor", "NrCAM interactions", "Activation of Ca-permeable Kainate Receptor", "RHO GTPases activate CIT", "RAF/MAP kinase cascade", "LGI-ADAM interactions", "Neurexins and neuroligins", "Neurexins and neuroligins", "Synaptic adhesion-like molecules", "Negative regulation of NMDA receptor-mediated neuronal transmission", "Long-term potentiation"], "P78356": ["Synthesis of PIPs at the plasma membrane", "PI5P Regulates TP53 Acetylation", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Synthesis of PIPs in the nucleus"], "P78357": ["Neurofascin interactions"], "P78363": ["Retinoid cycle disease events", "The canonical retinoid cycle in rods (twilight vision)", "The canonical retinoid cycle in rods (twilight vision)", "ABC-family proteins mediated transport"], "P78364": ["Oxidative Stress Induced Senescence", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of transcription cofactors", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA methylation proteins", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription", "Transcriptional Regulation by E2F6"], "P78367": ["Regulation of RUNX2 expression and activity"], "P78368": ["Sphingolipid de novo biosynthesis", "Disassembly of the destruction complex and recruitment of AXIN to the membrane"], "P78369": ["Tight junction interactions"], "P78371": ["Prefoldin mediated transfer of substrate to CCT/TriC", "Formation of tubulin folding intermediates by CCT/TriC", "Folding of actin by CCT/TriC", "Association of TriC/CCT with target proteins during biosynthesis", "Association of TriC/CCT with target proteins during biosynthesis", "BBSome-mediated cargo-targeting to cilium", "Neutrophil degranulation", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "P78380": ["Cell surface interactions at the vascular wall", "Neutrophil degranulation"], "P78381": ["Defective SLC35A2 causes congenital disorder of glycosylation 2M (CDG2M)", "Transport of nucleotide sugars"], "P78382": ["Sialic acid metabolism", "Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F)", "Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F)", "Transport of nucleotide sugars"], "P78385": ["Keratinization", "Formation of the cornified envelope"], "P78386": ["Keratinization", "Formation of the cornified envelope"], "P78396": ["G0 and Early G1", "Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Regulation of APC/C activators between G1/S and early anaphase", "SCF(Skp2)-mediated degradation of p27/p21", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "Activation of E2F1 target genes at G1/S", "Ub-specific processing proteases", "Processing of DNA double-strand break ends", "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "Regulation of TP53 Activity through Phosphorylation", "Regulation of TP53 Degradation", "G2 Phase", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Cyclin A/B1/B2 associated events during G2/M transition", "Cyclin A/B1/B2 associated events during G2/M transition", "p53-Dependent G1 DNA Damage Response", "Cyclin A:Cdk2-associated events at S phase entry"], "P78406": ["ISG15 antiviral mechanism", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "tRNA processing in the nucleus"], "P78410": ["Butyrophilin (BTN) family interactions"], "P78417": ["Methylation", "Glutathione conjugation", "Vitamin C (ascorbate) metabolism", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "P78423": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "P78426": ["Regulation of gene expression in beta cells", "Regulation of gene expression in early pancreatic precursor cells"], "P78504": ["Activated NOTCH1 Transmits Signal to the Nucleus", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant", "Constitutive Signaling by NOTCH1 HD Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "NOTCH2 Activation and Transmission of Signal to the Nucleus", "RUNX3 regulates NOTCH signaling", "NOTCH3 Activation and Transmission of Signal to the Nucleus", "NOTCH3 Activation and Transmission of Signal to the Nucleus", "NOTCH4 Activation and Transmission of Signal to the Nucleus"], "P78508": ["Activation of G protein gated Potassium channels", "Potassium transport channels", "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "P78509": ["Reelin signalling pathway"], "P78524": ["RAB GEFs exchange GTP for GDP on RABs"], "P78527": ["Cytosolic sensors of pathogen-associated DNA ", "IRF3-mediated induction of type I IFN", "Nonhomologous End-Joining (NHEJ)", "E3 ubiquitin ligases ubiquitinate target proteins"], "P78536": ["Nuclear signaling by ERBB4", "Collagen degradation", "Signaling by EGFR", "Regulated proteolysis of p75NTR", "Activated NOTCH1 Transmits Signal to the Nucleus", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant", "Constitutive Signaling by NOTCH1 HD Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "Release of Hh-Np from the secreting cell", "TNF signaling", "Growth hormone receptor signaling"], "P78537": ["Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis"], "P78540": ["Urea cycle"], "P78543": ["TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "P78545": ["Pre-NOTCH Transcription and Translation"], "P78549": ["Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "Cleavage of the damaged pyrimidine ", "Displacement of DNA glycosylase by APEX1"], "P78552": ["Interleukin-4 and Interleukin-13 signaling"], "P78556": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events", "Interleukin-10 signaling"], "P78560": ["TP53 Regulates Transcription of Caspase Activators and Caspases"], "P78563": ["C6 deamination of adenosine", "Formation of editosomes by ADAR proteins"], "P79483": ["Downstream TCR signaling", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "MHC class II antigen presentation", "PD-1 signaling", "Interferon gamma signaling"], "P80108": ["Post-translational modification: synthesis of GPI-anchored proteins"], "P80162": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "P80188": ["Interleukin-4 and Interleukin-13 signaling", "Neutrophil degranulation", "Metal sequestration by antimicrobial proteins", "Iron uptake and transport", "Iron uptake and transport"], "P80217": ["Interferon alpha/beta signaling"], "P80294": ["Metallothioneins bind metals"], "P80297": ["Metallothioneins bind metals"], "P80365": ["Glucocorticoid biosynthesis"], "P80370": ["Activated NOTCH1 Transmits Signal to the Nucleus"], "P80404": ["Degradation of GABA"], "P80511": ["TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "Neutrophil degranulation", "Advanced glycosylation endproduct receptor signaling", "Advanced glycosylation endproduct receptor signaling", "TRAF6 mediated NF-kB activation"], "P80748": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "P81274": ["G alpha (i) signalling events"], "P81277": ["Peptide ligand-binding receptors"], "P81534": ["Beta defensins", "Defensins"], "P81605": ["Antimicrobial peptides"], "P82094": ["Retrograde transport at the Trans-Golgi-Network"], "P82251": ["Basigin interactions", "Amino acid transport across the plasma membrane", "Defective SLC7A9 causes cystinuria (CSNU)"], "P82650": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "P82663": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "P82664": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "P82673": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "P82675": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "P82909": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "P82912": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "P82914": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "P82921": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "P82930": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "P82932": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "P82933": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "P82979": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA 3'-end processing"], "P82987": ["Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "P83369": ["Cleavage of Growing Transcript in the Termination Region ", "SLBP independent Processing of Histone Pre-mRNAs", "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"], "P83436": ["COPI-mediated anterograde transport", "Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network"], "P83731": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P83859": ["Orexin and neuropeptides FF and QRFP bind to their respective receptors", "G alpha (q) signalling events"], "P83876": ["mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "P83881": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P84022": ["Signaling by NODAL", "Signaling by NODAL", "Signaling by Activin", "Downregulation of TGF-beta receptor signaling", "TGF-beta receptor signaling activates SMADs", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "SMAD2/3 Phosphorylation Motif Mutants in Cancer", "SMAD4 MH2 Domain Mutants in Cancer", "SMAD2/3 MH2 Domain Mutants in Cancer", "TGFBR1 KD Mutants in Cancer", "Ub-specific processing proteases", "RUNX3 regulates CDKN1A transcription", "RUNX3 regulates BCL2L11 (BIM) transcription", "Interleukin-37 signaling", "NOTCH4 Intracellular Domain Regulates Transcription", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "FOXO-mediated transcription of cell cycle genes", "FOXO-mediated transcription of cell cycle genes"], "P84077": ["Synthesis of PIPs at the plasma membrane", "Synthesis of PIPs at the Golgi membrane", "Nef Mediated CD4 Down-regulation", "MHC class II antigen presentation", "Clathrin derived vesicle budding", "Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "Intra-Golgi traffic", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "P84085": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "P84095": ["GPVI-mediated activation cascade", "PIP3 activates AKT signaling", "Rho GTPase cycle", "Constitutive Signaling by Aberrant PI3K in Cancer", "RHO GTPases activate KTN1", "Neutrophil degranulation", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "P84098": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "P84103": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing"], "P84243": ["Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation", "Factors involved in megakaryocyte development and platelet production"], "P85037": ["UCH proteinases"], "P85298": ["Rho GTPase cycle"], "P85299": ["PIP3 activates AKT signaling", "CD28 dependent PI3K/Akt signaling", "VEGFR2 mediated vascular permeability", "Constitutive Signaling by AKT1 E17K in Cancer", "Regulation of TP53 Degradation"], "P86397": ["Fatty acyl-CoA biosynthesis"], "P86790": ["RAB GEFs exchange GTP for GDP on RABs"], "P86791": ["RAB GEFs exchange GTP for GDP on RABs"], "P98066": ["Neutrophil degranulation"], "P98077": ["Signalling to RAS", "Signalling to RAS", "VEGFA-VEGFR2 Pathway", "RAF/MAP kinase cascade"], "P98082": ["Gap junction degradation", "Formation of annular gap junctions", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "P98088": ["Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)", "Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)", "Defective GALNT12 causes colorectal cancer 1 (CRCS1)", "Dectin-2 family", "O-linked glycosylation of mucins", "Termination of O-glycan biosynthesis"], "P98095": ["Molecules associated with elastic fibres", "Molecules associated with elastic fibres"], "P98155": ["Reelin signalling pathway", "VLDLR internalisation and degradation", "VLDL clearance"], "P98160": ["Degradation of the extracellular matrix", "Degradation of the extracellular matrix", "A tetrasaccharide linker sequence is required for GAG synthesis", "HS-GAG biosynthesis", "HS-GAG biosynthesis", "HS-GAG degradation", "Integrin cell surface interactions", "Laminin interactions", "Laminin interactions", "Non-integrin membrane-ECM interactions", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "Defective B4GALT7 causes EDS, progeroid type", "Defective B3GAT3 causes JDSSDHD", "Defective EXT2 causes exostoses 2", "Defective EXT1 causes exostoses 1, TRPS2 and CHDS", "Defective B3GALT6 causes EDSP2 and SEMDJL1", "Retinoid metabolism and transport", "Amyloid fiber formation"], "P98161": ["VxPx cargo-targeting to cilium", "VxPx cargo-targeting to cilium"], "P98164": ["Vitamin D (calciferol) metabolism", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "Retinoid metabolism and transport"], "P98170": ["Activation of caspases through apoptosome-mediated cleavage", "SMAC (DIABLO) binds to IAPs ", "SMAC (DIABLO) binds to IAPs ", "SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ", "SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ", "SMAC, XIAP-regulated apoptotic response", "Deactivation of the beta-catenin transactivating complex", "RIPK1-mediated regulated necrosis", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "Regulation of necroptotic cell death", "Regulation of PTEN localization", "Regulation of PTEN stability and activity", "Regulation of the apoptosome activity"], "P98171": ["Rho GTPase cycle"], "P98172": ["EPH-Ephrin signaling", "EPH-Ephrin signaling", "EPHB-mediated forward signaling", "EPHB-mediated forward signaling", "Ephrin signaling", "Ephrin signaling", "EPH-ephrin mediated repulsion of cells"], "P98174": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "P98177": ["AKT phosphorylates targets in the nucleus", "Constitutive Signaling by AKT1 E17K in Cancer", "Ub-specific processing proteases", "Regulation of localization of FOXO transcription factors", "FOXO-mediated transcription of cell death genes", "FOXO-mediated transcription of cell death genes", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "Regulation of FOXO transcriptional activity by acetylation", "FOXO-mediated transcription of cell cycle genes", "FOXO-mediated transcription of cell cycle genes"], "P98182": ["Generic Transcription Pathway"], "P98187": ["Fatty acids", "Eicosanoids", "Synthesis of Leukotrienes (LT) and Eoxins (EX)"], "P98194": ["Ion transport by P-type ATPases"], "P98196": ["Neutrophil degranulation", "Ion transport by P-type ATPases"], "P98198": ["Ion transport by P-type ATPases"], "P99999": ["Release of apoptotic factors from the mitochondria", "Formation of apoptosome", "Activation of caspases through apoptosome-mediated cleavage", "SMAC (DIABLO) binds to IAPs ", "SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ", "Transcriptional activation of mitochondrial biogenesis", "Detoxification of Reactive Oxygen Species", "TP53 Regulates Metabolic Genes", "Respiratory electron transport", "Regulation of the apoptosome activity", "Regulation of the apoptosome activity"], "P9WFZ7": ["Tolerance by Mtb to nitric oxide produced by macrophages"], "P9WFZ9": ["Tolerance by Mtb to nitric oxide produced by macrophages"], "P9WG35": ["Tolerance by Mtb to nitric oxide produced by macrophages", "Cell redox homeostasis"], "P9WG67": ["Tolerance by Mtb to nitric oxide produced by macrophages", "Cell redox homeostasis"], "P9WGE7": ["Tolerance of reactive oxygen produced by macrophages"], "P9WGE9": ["Tolerance of reactive oxygen produced by macrophages"], "P9WGN3": ["Tolerance of reactive oxygen produced by macrophages"], "P9WGN5": ["Tolerance of reactive oxygen produced by macrophages"], "P9WGN7": ["Tolerance of reactive oxygen produced by macrophages"], "P9WGN9": ["Tolerance of reactive oxygen produced by macrophages"], "P9WGP1": ["Tolerance of reactive oxygen produced by macrophages"], "P9WGP3": ["Tolerance of reactive oxygen produced by macrophages"], "P9WGP5": ["Tolerance of reactive oxygen produced by macrophages"], "P9WGU5": ["Tolerance by Mtb to nitric oxide produced by macrophages"], "P9WHH1": ["Cell redox homeostasis"], "P9WHH9": ["Cell redox homeostasis"], "P9WIE3": ["Tolerance by Mtb to nitric oxide produced by macrophages"], "P9WIE5": ["Tolerance of reactive oxygen produced by macrophages"], "P9WIS7": ["Cell redox homeostasis"], "P9WJM5": ["Tolerance by Mtb to nitric oxide produced by macrophages"], "P9WL31": ["Mtb iron assimilation by chelation", "Mtb iron assimilation by chelation"], "P9WN25": ["Tolerance by Mtb to nitric oxide produced by macrophages"], "P9WNE1": ["Cell redox homeostasis"], "P9WNE5": ["Mtb iron assimilation by chelation"], "P9WPQ9": ["Mtb iron assimilation by chelation"], "P9WQB5": ["Cell redox homeostasis"], "P9WQB7": ["Tolerance of reactive oxygen produced by macrophages", "Tolerance by Mtb to nitric oxide produced by macrophages", "Cell redox homeostasis"], "P9WQJ5": ["Tolerance by Mtb to nitric oxide produced by macrophages"], "P9WQJ7": ["Mtb iron assimilation by chelation", "Mtb iron assimilation by chelation"], "P9WQJ9": ["Mtb iron assimilation by chelation", "Mtb iron assimilation by chelation"], "Q00056": ["Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "Q00059": ["Mitochondrial transcription initiation", "Transcriptional activation of mitochondrial biogenesis", "Transcriptional activation of mitochondrial biogenesis"], "Q00169": ["Role of second messengers in netrin-1 signaling", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "Q00266": ["Methylation", "Sulfur amino acid metabolism", "Metabolism of ingested SeMet, Sec, MeSec into H2Se", "Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD)"], "Q00341": ["HDL clearance"], "Q00403": ["HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "RNA Polymerase II Pre-transcription Events", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "Q00496": ["Toxicity of botulinum toxin type E (BoNT/E)"], "Q00534": ["Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "Oncogene Induced Senescence", "Cyclin D associated events in G1", "Regulation of RUNX1 Expression and Activity"], "Q00535": ["DARPP-32 events", "CRMPs in Sema3A signaling", "CRMPs in Sema3A signaling", "Regulation of TP53 Activity through Phosphorylation", "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "Activated NTRK2 signals through CDK5", "Factors involved in megakaryocyte development and platelet production"], "Q00597": ["Fanconi Anemia Pathway", "TP53 Regulates Transcription of DNA Repair Genes"], "Q00610": ["Entry of Influenza Virion into Host Cell via Endocytosis", "Retrograde neurotrophin signalling", "Retrograde neurotrophin signalling", "Gap junction degradation", "Formation of annular gap junctions", "MHC class II antigen presentation", "EPH-ephrin mediated repulsion of cells", "Lysosome Vesicle Biogenesis", "Recycling pathway of L1", "Recycling pathway of L1", "WNT5A-dependent internalization of FZD4", "WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "VLDLR internalisation and degradation", "LDL clearance"], "Q00610-1": ["MHC class II antigen presentation", "Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis"], "Q00613": ["Regulation of HSF1-mediated heat shock response", "HSF1 activation", "Attenuation phase", "HSF1-dependent transactivation"], "Q00653": ["RIP-mediated NFkB activation via ZBP1", "DEx/H-box helicases activate type I IFN and inflammatory cytokines production ", "PKMTs methylate histone lysines", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "Interleukin-1 processing", "SUMOylation of immune response proteins", "IkBA variant leads to EDA-ID", "Dectin-1 mediated noncanonical NF-kB signaling", "NIK-->noncanonical NF-kB signaling", "The NLRP3 inflammasome", "TRAF6 mediated NF-kB activation"], "Q00722": ["PLC beta mediated events", "PLC beta mediated events", "Synthesis of IP3 and IP4 in the cytosol", "Acetylcholine regulates insulin secretion", "Acetylcholine regulates insulin secretion", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (q) signalling events", "G beta:gamma signalling through PLC beta", "Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "Presynaptic function of Kainate receptors"], "Q00765": ["Olfactory Signaling Pathway"], "Q00796": ["Fructose biosynthesis", "Formation of xylulose-5-phosphate"], "Q00839": ["mRNA Splicing - Major Pathway", "Processing of Capped Intron-Containing Pre-mRNA"], "Q00872": ["Striated Muscle Contraction"], "Q00887": ["Cell surface interactions at the vascular wall"], "Q00888": ["Cell surface interactions at the vascular wall"], "Q00889": ["Cell surface interactions at the vascular wall"], "Q00973": ["Glycosphingolipid metabolism"], "Q00975": ["Presynaptic depolarization and calcium channel opening"], "Q00978": ["Interferon gamma signaling", "Interferon alpha/beta signaling"], "Q00987": ["AKT phosphorylates targets in the cytosol", "Oxidative Stress Induced Senescence", "Oncogene Induced Senescence", "SUMOylation of transcription factors", "SUMOylation of ubiquitinylation proteins", "Trafficking of AMPA receptors", "Constitutive Signaling by AKT1 E17K in Cancer", "Ub-specific processing proteases", "Regulation of TP53 Activity through Phosphorylation", "Regulation of TP53 Degradation", "Regulation of TP53 Activity through Methylation", "Stabilization of p53", "Regulation of RUNX3 expression and activity"], "Q00994": ["NADE modulates death signalling"], "Q01064": ["Cam-PDE 1 activation", "cGMP effects", "G alpha (s) signalling events"], "Q01081": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing"], "Q01082": ["Nephrin family interactions", "NCAM signaling for neurite out-growth", "NCAM signaling for neurite out-growth", "Interaction between L1 and Ankyrins", "Interaction between L1 and Ankyrins", "RAF/MAP kinase cascade", "COPI-mediated anterograde transport"], "Q01085": ["FGFR2 alternative splicing"], "Q01094": ["Activation of NOXA and translocation to mitochondria", "Inhibition of replication initiation of damaged DNA by RB1/E2F1", "Transcription of E2F targets under negative control by DREAM complex", "Transcription of E2F targets under negative control by DREAM complex", "Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1", "Activation of PUMA and translocation to mitochondria", "Pre-NOTCH Transcription and Translation", "Pre-NOTCH Transcription and Translation", "Oxidative Stress Induced Senescence", "Oncogene Induced Senescence", "Activation of E2F1 target genes at G1/S", "Activation of E2F1 target genes at G1/S", "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "CDC6 association with the ORC:origin complex", "G2 Phase", "Cyclin E associated events during G1/S transition ", "Cyclin D associated events in G1", "Cyclin A:Cdk2-associated events at S phase entry", "Transcriptional Regulation by E2F6"], "Q01101": ["Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells"], "Q01105": ["Condensation of Prophase Chromosomes", "HuR (ELAVL1) binds and stabilizes mRNA"], "Q01113": ["Interleukin-9 signaling"], "Q01118": ["Interaction between L1 and Ankyrins", "Phase 0 - rapid depolarisation"], "Q01130": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "mRNA 3'-end processing"], "Q01167": ["UCH proteinases"], "Q01196": ["Pre-NOTCH Transcription and Translation", "Organic cation transport", "RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "RUNX1 regulates estrogen receptor mediated transcription", "Regulation of RUNX1 Expression and Activity", "Regulation of RUNX1 Expression and Activity", "RUNX1 regulates expression of components of tight junctions", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "RUNX1 regulates transcription of genes involved in differentiation of keratinocytes", "RUNX1 regulates transcription of genes involved in differentiation of keratinocytes", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "RUNX1 regulates transcription of genes involved in BCR signaling", "RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "RUNX1 regulates transcription of genes involved in interleukin signaling", "RUNX1 regulates transcription of genes involved in WNT signaling", "RUNX2 regulates genes involved in differentiation of myeloid cells", "RUNX3 regulates p14-ARF", "Estrogen-dependent gene expression"], "Q01201": ["Dectin-1 mediated noncanonical NF-kB signaling", "CD209 (DC-SIGN) signaling", "NIK-->noncanonical NF-kB signaling"], "Q01344": ["Interleukin-3, Interleukin-5 and GM-CSF signaling", "RAF/MAP kinase cascade", "Interleukin receptor SHC signaling"], "Q01362": ["Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation"], "Q01432": ["Neutrophil degranulation", "Purine salvage"], "Q01433": ["Purine salvage"], "Q01449": ["Smooth Muscle Contraction"], "Q01469": ["Triglyceride catabolism", "Signaling by Retinoic Acid", "Neutrophil degranulation"], "Q01484": ["Interaction between L1 and Ankyrins", "Interaction between L1 and Ankyrins", "COPI-mediated anterograde transport"], "Q01518": ["Platelet degranulation ", "Role of ABL in ROBO-SLIT signaling", "Neutrophil degranulation"], "Q01523": ["Defensins", "Alpha-defensins"], "Q01524": ["Defensins", "Alpha-defensins"], "Q01546": ["Keratinization", "Formation of the cornified envelope"], "Q01581": ["Cholesterol biosynthesis", "PPARA activates gene expression", "Activation of gene expression by SREBF (SREBP)"], "Q01628": ["Interferon alpha/beta signaling"], "Q01629": ["Interferon alpha/beta signaling"], "Q01638": ["PIP3 activates AKT signaling", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Interleukin-33 signaling"], "Q01638-2": ["Interleukin-33 signaling"], "Q01650": ["Basigin interactions", "Amino acid transport across the plasma membrane", "Tryptophan catabolism"], "Q01658": ["HATs acetylate histones"], "Q01668": ["Adrenaline,noradrenaline inhibits insulin secretion", "NCAM1 interactions", "Regulation of insulin secretion", "Regulation of insulin secretion", "Phase 0 - rapid depolarisation", "Phase 2 - plateau phase"], "Q01718": ["Peptide ligand-binding receptors", "G alpha (s) signalling events", "Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)"], "Q01726": ["Peptide ligand-binding receptors", "G alpha (s) signalling events"], "Q01740": ["FMO oxidises nucleophiles"], "Q01780": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "Q01813": ["Glycolysis"], "Q01814": ["Reduction of cytosolic Ca++ levels", "Ion homeostasis", "Ion transport by P-type ATPases"], "Q01826": ["Apoptotic cleavage of cellular proteins", "SUMOylation of chromatin organization proteins"], "Q01831": ["SUMOylation of DNA damage response and repair proteins", "DNA Damage Recognition in GG-NER", "Formation of Incision Complex in GG-NER"], "Q01851": ["Regulation of TP53 Activity through Association with Co-factors"], "Q01860": ["POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation", "POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation", "Transcriptional regulation of pluripotent stem cells"], "Q01955": ["Collagen degradation", "Collagen degradation", "Extracellular matrix organization", "Collagen biosynthesis and modifying enzymes", "Signaling by PDGF", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "Integrin cell surface interactions", "Anchoring fibril formation", "Crosslinking of collagen fibrils", "Laminin interactions", "Laminin interactions", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "NCAM1 interactions", "Collagen chain trimerization"], "Q01959": ["Dopamine clearance from the synaptic cleft", "Na+/Cl- dependent neurotransmitter transporters", "Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)", "Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)"], "Q01968": ["Synthesis of PIPs at the plasma membrane", "Synthesis of PIPs at the Golgi membrane", "Synthesis of IP2, IP, and Ins in the cytosol", "Synthesis of IP3 and IP4 in the cytosol", "Rho GTPase cycle", "Golgi Associated Vesicle Biogenesis", "Clathrin-mediated endocytosis"], "Q01970": ["PLC beta mediated events", "PLC beta mediated events", "Synthesis of IP3 and IP4 in the cytosol", "Acetylcholine regulates insulin secretion", "Acetylcholine regulates insulin secretion", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (q) signalling events", "G beta:gamma signalling through PLC beta", "Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "Presynaptic function of Kainate receptors"], "Q01973": ["WNT5A-dependent internalization of FZD2, FZD5 and ROR2"], "Q01974": ["PCP/CE pathway", "WNT5A-dependent internalization of FZD2, FZD5 and ROR2"], "Q02045": ["Smooth Muscle Contraction"], "Q02078": ["ERK/MAPK targets", "CDO in myogenesis"], "Q02080": ["CDO in myogenesis"], "Q02083": ["Neurotransmitter release cycle"], "Q02094": ["Erythrocytes take up carbon dioxide and release oxygen", "Erythrocytes take up oxygen and release carbon dioxide", "Rhesus glycoproteins mediate ammonium transport.", "Defective RHAG causes regulator type Rh-null hemolytic anemia (RHN)"], "Q02108": ["Nitric oxide stimulates guanylate cyclase", "Smooth Muscle Contraction"], "Q02127": ["Pyrimidine biosynthesis"], "Q02153": ["Nitric oxide stimulates guanylate cyclase", "Smooth Muscle Contraction"], "Q02156": ["Effects of PIP2 hydrolysis", "SHC1 events in ERBB2 signaling", "DAG and IP3 signaling", "Role of phospholipids in phagocytosis", "G alpha (z) signalling events"], "Q02218": ["Glyoxylate metabolism and glycine degradation", "Lysine catabolism", "Citric acid cycle (TCA cycle)"], "Q02223": ["TNFs bind their physiological receptors"], "Q02224": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "COPI-dependent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "Kinesins"], "Q02241": ["MHC class II antigen presentation", "COPI-dependent Golgi-to-ER retrograde traffic", "Mitotic Telophase/Cytokinesis", "Kinesins"], "Q02246": ["L1CAM interactions", "NCAM1 interactions", "NrCAM interactions"], "Q02252": ["Branched-chain amino acid catabolism"], "Q02297": ["Signaling by ERBB2", "Signaling by ERBB4", "SHC1 events in ERBB2 signaling", "SHC1 events in ERBB2 signaling", "PI3K events in ERBB4 signaling", "SHC1 events in ERBB4 signaling", "Nuclear signaling by ERBB4", "PIP3 activates AKT signaling", "GRB7 events in ERBB2 signaling", "Downregulation of ERBB2:ERBB3 signaling", "GRB2 events in ERBB2 signaling", "PI3K events in ERBB2 signaling", "Constitutive Signaling by Aberrant PI3K in Cancer", "RAF/MAP kinase cascade", "ERBB2 Regulates Cell Motility", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "ERBB2 Activates PTK6 Signaling", "Downregulation of ERBB2 signaling", "Long-term potentiation"], "Q02297-10": ["Signaling by ERBB2", "Signaling by ERBB4", "SHC1 events in ERBB2 signaling", "SHC1 events in ERBB2 signaling", "PIP3 activates AKT signaling", "GRB7 events in ERBB2 signaling", "Downregulation of ERBB2:ERBB3 signaling", "PI3K events in ERBB2 signaling", "Constitutive Signaling by Aberrant PI3K in Cancer", "RAF/MAP kinase cascade", "ERBB2 Regulates Cell Motility", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "ERBB2 Activates PTK6 Signaling", "Downregulation of ERBB2 signaling"], "Q02318": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of bile acids and bile salts via 24-hydroxycholesterol", "Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "Endogenous sterols", "Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX)"], "Q02338": ["Utilization of Ketone Bodies", "Synthesis of Ketone Bodies"], "Q02386": ["Generic Transcription Pathway"], "Q02388": ["Collagen degradation", "Collagen degradation", "Extracellular matrix organization", "Collagen biosynthesis and modifying enzymes", "Assembly of collagen fibrils and other multimeric structures", "COPII-mediated vesicle transport", "Integrin cell surface interactions", "Anchoring fibril formation", "Laminin interactions", "Laminin interactions", "Cargo concentration in the ER", "Collagen chain trimerization"], "Q02410": ["Dopamine Neurotransmitter Release Cycle", "Neurexins and neuroligins"], "Q02413": ["Apoptotic cleavage of cell adhesion proteins", "Neutrophil degranulation", "Keratinization", "Formation of the cornified envelope"], "Q02447": ["SUMOylation of transcription factors"], "Q02487": ["Keratinization", "Formation of the cornified envelope"], "Q02505": ["Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)", "Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)", "Defective GALNT12 causes colorectal cancer 1 (CRCS1)", "Dectin-2 family", "O-linked glycosylation of mucins", "Termination of O-glycan biosynthesis"], "Q02539": ["Activation of DNA fragmentation factor", "Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "Q02543": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "Q02548": ["RUNX1 regulates transcription of genes involved in BCR signaling"], "Q02556": ["Interferon gamma signaling", "Interferon alpha/beta signaling"], "Q02641": ["Presynaptic depolarization and calcium channel opening", "NCAM1 interactions", "Phase 0 - rapid depolarisation", "Phase 2 - plateau phase"], "Q02643": ["G alpha (s) signalling events", "Glucagon-type ligand receptors"], "Q02742": ["O-linked glycosylation of mucins"], "Q02747": ["Digestion"], "Q02750": ["MAPK3 (ERK1) activation", "Signal transduction by L1", "Uptake and function of anthrax toxins", "RAF activation", "MAP2K and MAPK activation", "Negative feedback regulation of MAPK pathway", "MAP3K8 (TPL2)-dependent MAPK1/3 activation", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF"], "Q02763": ["Tie2 Signaling", "Tie2 Signaling", "RAF/MAP kinase cascade"], "Q02790": ["HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Attenuation phase", "ESR-mediated signaling", "Estrogen-dependent gene expression"], "Q02809": ["Collagen biosynthesis and modifying enzymes"], "Q02817": ["Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)", "Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)", "Defective GALNT12 causes colorectal cancer 1 (CRCS1)", "Dectin-2 family", "O-linked glycosylation of mucins", "Termination of O-glycan biosynthesis"], "Q02818": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "Q02846": ["Inactivation, recovery and regulation of the phototransduction cascade"], "Q02878": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "Q02880": ["SUMOylation of DNA replication proteins"], "Q02928": ["PPARA activates gene expression", "Fatty acids", "Miscellaneous substrates", "Eicosanoids", "Synthesis of Leukotrienes (LT) and Eoxins (EX)", "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)"], "Q02978": ["Gluconeogenesis"], "Q02985": ["Regulation of Complement cascade"], "Q03001": ["Type I hemidesmosome assembly"], "Q03001-3": ["Assembly of collagen fibrils and other multimeric structures"], "Q03013": ["Glutathione conjugation", "Biosynthesis of maresin conjugates in tissue regeneration (MCTR)"], "Q03060-6": ["Circadian Clock"], "Q03111": ["Formation of RNA Pol II elongation complex ", "RNA Polymerase II Pre-transcription Events", "RNA Polymerase II Transcription Elongation"], "Q03112": ["PKMTs methylate histone lysines", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription"], "Q03113": ["G alpha (12/13) signalling events", "Thrombin signalling through proteinase activated receptors (PARs)", "Thrombin signalling through proteinase activated receptors (PARs)"], "Q03135": ["Triglyceride catabolism", "eNOS activation", "NOSTRIN mediated eNOS trafficking", "Basigin interactions", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "VEGFR2 mediated vascular permeability", "FOXO-mediated transcription of cell cycle genes"], "Q03154": ["Aflatoxin activation and detoxification", "Defective ACY1 causes encephalopathy"], "Q03164": ["PKMTs methylate histone lysines", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "RUNX1 regulates transcription of genes involved in differentiation of HSCs"], "Q03181": ["Import of palmitoyl-CoA into the mitochondrial matrix", "Regulation of pyruvate dehydrogenase (PDH) complex", "Nuclear Receptor transcription pathway", "Signaling by Retinoic Acid"], "Q03188": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Deposition of new CENPA-containing nucleosomes at the centromere", "Mitotic Prometaphase"], "Q03393": ["Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation"], "Q03405": ["Attachment of GPI anchor to uPAR", "Neutrophil degranulation", "Dissolution of Fibrin Clot"], "Q03426": ["Cholesterol biosynthesis", "Activation of gene expression by SREBF (SREBP)"], "Q03431": ["Class B/2 (Secretin family receptors)", "G alpha (s) signalling events"], "Q03468": ["ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "B-WICH complex positively regulates rRNA expression", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "RNA Polymerase I Transcription Initiation"], "Q03518": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "Q03519": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "Q03591": ["Regulation of Complement cascade"], "Q03692": ["Collagen degradation", "Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "Non-integrin membrane-ECM interactions", "Collagen chain trimerization"], "Q03721": ["Voltage gated Potassium channels"], "Q03936": ["Generic Transcription Pathway"], "Q04206": ["Activation of NF-kappaB in B cells", "RIP-mediated NFkB activation via ZBP1", "Regulated proteolysis of p75NTR", "Downstream TCR signaling", "NF-kB is activated and signals survival", "Senescence-Associated Secretory Phenotype (SASP)", "FCERI mediated NF-kB activation", "DEx/H-box helicases activate type I IFN and inflammatory cytokines production ", "PKMTs methylate histone lysines", "Transcriptional regulation of white adipocyte differentiation", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "Interleukin-1 processing", "SUMOylation of immune response proteins", "IkBA variant leads to EDA-ID", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "CD209 (DC-SIGN) signaling", "CLEC7A/inflammasome pathway", "The NLRP3 inflammasome", "Interleukin-1 signaling", "TRAF6 mediated NF-kB activation"], "Q04323": ["N-glycan trimming in the ER and Calnexin/Calreticulin cycle"], "Q04446": ["Glycogen synthesis", "Glycogen storage disease type IV (GBE1)"], "Q04609": ["Amino acid synthesis and interconversion (transamination)"], "Q04637": ["ISG15 antiviral mechanism", "L13a-mediated translational silencing of Ceruloplasmin expression", "mTORC1-mediated signalling", "Deadenylation of mRNA", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Translation initiation complex formation", "Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "Q04656": ["Detoxification of Reactive Oxygen Species", "Ion influx/efflux at host-pathogen interface", "Ion transport by P-type ATPases"], "Q04671": ["Melanin biosynthesis"], "Q04695": ["Keratinization", "Formation of the cornified envelope"], "Q04721": ["Pre-NOTCH Processing in the Endoplasmic Reticulum", "Pre-NOTCH Transcription and Translation", "Pre-NOTCH Processing in Golgi", "Pre-NOTCH Processing in Golgi", "NOTCH2 intracellular domain regulates transcription", "NOTCH2 intracellular domain regulates transcription", "NOTCH2 Activation and Transmission of Signal to the Nucleus", "NOTCH2 Activation and Transmission of Signal to the Nucleus", "Notch-HLH transcription pathway", "Defective LFNG causes SCDO3", "NOTCH4 Intracellular Domain Regulates Transcription"], "Q04724": ["Formation of the beta-catenin:TCF transactivating complex", "NOTCH1 Intracellular Domain Regulates Transcription", "Deactivation of the beta-catenin transactivating complex", "Repression of WNT target genes", "Repression of WNT target genes"], "Q04725": ["Formation of the beta-catenin:TCF transactivating complex", "NOTCH1 Intracellular Domain Regulates Transcription", "Deactivation of the beta-catenin transactivating complex", "Repression of WNT target genes", "Repression of WNT target genes"], "Q04726": ["Formation of the beta-catenin:TCF transactivating complex", "Deactivation of the beta-catenin transactivating complex", "Repression of WNT target genes", "Repression of WNT target genes", "Estrogen-dependent gene expression"], "Q04726-3": ["NOTCH1 Intracellular Domain Regulates Transcription"], "Q04727": ["Formation of the beta-catenin:TCF transactivating complex", "NOTCH1 Intracellular Domain Regulates Transcription", "Deactivation of the beta-catenin transactivating complex", "Repression of WNT target genes", "Repression of WNT target genes"], "Q04756": ["MET Receptor Activation"], "Q04759": ["Apoptotic cleavage of cellular proteins", "Effects of PIP2 hydrolysis", "Downstream TCR signaling", "Inactivation, recovery and regulation of the phototransduction cascade", "FCERI mediated NF-kB activation", "FCERI mediated NF-kB activation", "Netrin-1 signaling", "G alpha (z) signalling events", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"], "Q04760": ["Pyruvate metabolism"], "Q04826": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "Q04828": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of bile acids and bile salts via 24-hydroxycholesterol", "Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "Retinoid metabolism and transport"], "Q04837": ["Transcriptional activation of mitochondrial biogenesis"], "Q04844": ["Highly sodium permeable acetylcholine nicotinic receptors"], "Q04864": ["Activation of NF-kappaB in B cells"], "Q04874": ["Cell surface interactions at the vascular wall"], "Q04875": ["Cell surface interactions at the vascular wall"], "Q04876": ["Cell surface interactions at the vascular wall"], "Q04877": ["Cell surface interactions at the vascular wall"], "Q04878": ["Cell surface interactions at the vascular wall"], "Q04879": ["Cell surface interactions at the vascular wall"], "Q04880": ["Cell surface interactions at the vascular wall"], "Q04881": ["Cell surface interactions at the vascular wall"], "Q04882": ["Cell surface interactions at the vascular wall"], "Q04883": ["Cell surface interactions at the vascular wall"], "Q04884": ["Cell surface interactions at the vascular wall"], "Q04885": ["Cell surface interactions at the vascular wall"], "Q04912": ["Signaling by MST1"], "Q04917": ["Activation of BAD and translocation to mitochondria ", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "RHO GTPases activate PKNs", "TP53 Regulates Metabolic Genes", "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex"], "Q05033": ["Cell surface interactions at the vascular wall"], "Q05034": ["Cell surface interactions at the vascular wall"], "Q05048": ["Cleavage of Growing Transcript in the Termination Region ", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "Q05066": ["Deactivation of the beta-catenin transactivating complex"], "Q05086": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q05193": ["Toll Like Receptor 4 (TLR4) Cascade", "Retrograde neurotrophin signalling", "Gap junction degradation", "Formation of annular gap junctions", "MHC class II antigen presentation", "EPH-ephrin mediated repulsion of cells", "Recycling pathway of L1", "Clathrin-mediated endocytosis"], "Q05209": ["SHC1 events in ERBB2 signaling", "SHC1 events in ERBB2 signaling", "EGFR downregulation", "Signaling by PDGF", "Downregulation of ERBB2 signaling", "Interleukin-37 signaling"], "Q05329": ["GABA synthesis", "GABA synthesis, release, reuptake and degradation", "MECP2 regulates transcription of genes involved in GABA signaling"], "Q05397": ["Apoptotic cleavage of cellular proteins", "Regulation of actin dynamics for phagocytic cup formation", "Integrin alphaIIb beta3 signaling", "GRB2:SOS provides linkage to MAPK signaling for Integrins ", "p130Cas linkage to MAPK signaling for integrins", "NCAM signaling for neurite out-growth", "NCAM signaling for neurite out-growth", "Signal regulatory protein family interactions", "EPHB-mediated forward signaling", "EPHB-mediated forward signaling", "DCC mediated attractive signaling", "DCC mediated attractive signaling", "VEGFA-VEGFR2 Pathway", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate WASPs and WAVEs", "RAF/MAP kinase cascade", "MET activates PTK2 signaling"], "Q05469": ["Triglyceride catabolism"], "Q05513": ["GPVI-mediated activation cascade", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "VEGFR2 mediated cell proliferation", "RHO GTPases Activate NADPH Oxidases"], "Q05516": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q05519": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing"], "Q05586": ["EPHB-mediated forward signaling", "EPHB-mediated forward signaling", "Unblocking of NMDA receptors, glutamate binding and activation", "Unblocking of NMDA receptors, glutamate binding and activation", "Ras activation upon Ca2+ influx through NMDA receptor", "RAF/MAP kinase cascade", "Neurexins and neuroligins", "Synaptic adhesion-like molecules", "Negative regulation of NMDA receptor-mediated neuronal transmission", "Long-term potentiation"], "Q05639": ["Eukaryotic Translation Elongation"], "Q05655": ["Apoptotic cleavage of cellular proteins", "Calmodulin induced events", "Effects of PIP2 hydrolysis", "SHC1 events in ERBB2 signaling", "DAG and IP3 signaling", "Role of phospholipids in phagocytosis", "G alpha (z) signalling events", "HuR (ELAVL1) binds and stabilizes mRNA", "VEGFR2 mediated cell proliferation", "CLEC7A (Dectin-1) signaling", "RHO GTPases Activate NADPH Oxidases", "Neutrophil degranulation", "Interferon gamma signaling"], "Q05682": ["Smooth Muscle Contraction"], "Q05707": ["Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Assembly of collagen fibrils and other multimeric structures", "Collagen chain trimerization"], "Q05823": ["OAS antiviral response", "Interferon alpha/beta signaling"], "Q05901": ["Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "Highly calcium permeable nicotinic acetylcholine receptors"], "Q05923": ["RAF-independent MAPK1/3 activation", "Negative regulation of MAPK pathway"], "Q05932-1": ["Metabolism of folate and pterines"], "Q05932-2": ["Metabolism of folate and pterines"], "Q05940": ["Serotonin Neurotransmitter Release Cycle", "Norepinephrine Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle", "Na+/Cl- dependent neurotransmitter transporters"], "Q05996": ["Interaction With The Zona Pellucida"], "Q06033": ["Platelet degranulation "], "Q06055": ["Formation of ATP by chemiosmotic coupling", "Cristae formation"], "Q06124": ["Interleukin-6 signaling", "PI3K Cascade", "MAPK3 (ERK1) activation", "MAPK1 (ERK2) activation", "GPVI-mediated activation cascade", "Prolactin receptor signaling", "PIP3 activates AKT signaling", "Spry regulation of FGF signaling", "Signaling by SCF-KIT", "GAB1 signalosome", "Downstream signal transduction", "PECAM1 interactions", "Tie2 Signaling", "Constitutive Signaling by Aberrant PI3K in Cancer", "Signaling by Leptin", "Costimulation by the CD28 family", "CTLA4 inhibitory signaling", "PD-1 signaling", "Signal regulatory protein family interactions", "Netrin mediated repulsion signals", "Platelet sensitization by LDL", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "FRS-mediated FGFR2 signaling", "FRS-mediated FGFR3 signaling", "PI-3K cascade:FGFR3", "FRS-mediated FGFR4 signaling", "PI-3K cascade:FGFR4", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Regulation of IFNG signaling", "RET signaling", "Interleukin-20 family signaling", "MET activates PTPN11", "Regulation of RUNX1 Expression and Activity", "Interleukin-37 signaling", "Activated NTRK2 signals through FRS2 and FRS3", "Interferon alpha/beta signaling", "Regulation of IFNA signaling", "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon"], "Q06136": ["Sphingolipid de novo biosynthesis"], "Q06141": ["Antimicrobial peptides"], "Q06187": ["ER-Phagosome pathway", "MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "Regulation of actin dynamics for phagocytic cup formation", "DAP12 signaling", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "MyD88 deficiency (TLR2/4)", "IRAK4 deficiency (TLR2/4)", "RHO GTPases Activate WASPs and WAVEs", "G beta:gamma signalling through BTK", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "Q06203": ["Purine ribonucleoside monophosphate biosynthesis"], "Q06210": ["XBP1(S) activates chaperone genes", "Defective GFPT1 causes CMSTA1", "Synthesis of UDP-N-acetyl-glucosamine"], "Q06265": ["ATF4 activates genes", "mRNA decay by 3' to 5' exoribonuclease", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "KSRP (KHSRP) binds and destabilizes mRNA", "Major pathway of rRNA processing in the nucleolus and cytosol"], "Q06278": ["Vitamins B6 activation to pyridoxal phosphate"], "Q06323": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q06330": ["Pre-NOTCH Transcription and Translation", "Pre-NOTCH Transcription and Translation", "Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "NOTCH1 Intracellular Domain Regulates Transcription", "NOTCH1 Intracellular Domain Regulates Transcription", "NOTCH2 intracellular domain regulates transcription", "NOTCH2 intracellular domain regulates transcription", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "Notch-HLH transcription pathway", "RUNX3 regulates NOTCH signaling", "RUNX3 regulates NOTCH signaling", "NOTCH3 Intracellular Domain Regulates Transcription", "NOTCH3 Intracellular Domain Regulates Transcription", "NOTCH4 Intracellular Domain Regulates Transcription", "NOTCH4 Intracellular Domain Regulates Transcription"], "Q06413": ["ERK/MAPK targets", "Transcriptional activation of mitochondrial biogenesis", "CDO in myogenesis", "Circadian Clock", "MECP2 regulates transcription factors"], "Q06432": ["Phase 0 - rapid depolarisation", "Phase 2 - plateau phase"], "Q06481": ["Platelet degranulation ", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "Q06495": ["Type II Na+/Pi cotransporters", "Defective SLC34A1 causes hypophosphatemic nephrolithiasis/osteoporosis 1 (NPHLOP1)", "Surfactant metabolism"], "Q06520": ["Cytosolic sulfonation of small molecules", "PPARA activates gene expression"], "Q06546": ["Transcriptional activation of mitochondrial biogenesis"], "Q06547-1": ["Transcriptional activation of mitochondrial biogenesis"], "Q06547-2": ["Transcriptional activation of mitochondrial biogenesis"], "Q06547-3": ["Transcriptional activation of mitochondrial biogenesis"], "Q06547-4": ["Transcriptional activation of mitochondrial biogenesis"], "Q06587": ["Oxidative Stress Induced Senescence", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of transcription cofactors", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA methylation proteins", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription", "Transcriptional Regulation by E2F6"], "Q06609": ["HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange", "Presynaptic phase of homologous DNA pairing and strand exchange", "Transcriptional Regulation by E2F6", "Meiotic recombination"], "Q06643": ["TNFR2 non-canonical NF-kB pathway", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "Q06730": ["Generic Transcription Pathway"], "Q06732": ["Generic Transcription Pathway"], "Q06828": ["Keratan sulfate biosynthesis", "Keratan sulfate degradation", "ECM proteoglycans", "Defective CHST6 causes MCDC1", "Defective ST3GAL3 causes MCT12 and EIEE15", "Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)"], "Q06830": ["Detoxification of Reactive Oxygen Species", "TP53 Regulates Metabolic Genes", "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models"], "Q06945": ["Deactivation of the beta-catenin transactivating complex"], "Q07000": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "Q07001": ["Highly sodium permeable acetylcholine nicotinic receptors"], "Q07011": ["TNFs bind their physiological receptors"], "Q07020": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "Q07021": ["Intrinsic Pathway of Fibrin Clot Formation"], "Q07065": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Surfactant metabolism", "Neutrophil degranulation", "Post-translational protein phosphorylation"], "Q07075": ["Metabolism of Angiotensinogen to Angiotensins"], "Q07092": ["Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Integrin cell surface interactions", "Collagen chain trimerization"], "Q07157": ["c-src mediated regulation of Cx43 function and closure of gap junctions", "c-src mediated regulation of Cx43 function and closure of gap junctions", "Signaling by Hippo", "Apoptotic cleavage of cell adhesion proteins", "RUNX1 regulates expression of components of tight junctions"], "Q07283": ["Formation of the cornified envelope"], "Q07325": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "Q07326": ["Synthesis of glycosylphosphatidylinositol (GPI)", "Synthesis of glycosylphosphatidylinositol (GPI)"], "Q07343": ["DARPP-32 events", "G alpha (s) signalling events"], "Q07352": ["Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA"], "Q07627": ["Keratinization"], "Q07654": ["Estrogen-dependent gene expression"], "Q07666": ["PTK6 Regulates Proteins Involved in RNA Processing"], "Q07699": ["Interaction between L1 and Ankyrins", "Phase 0 - rapid depolarisation"], "Q07812": ["Release of apoptotic factors from the mitochondria", "Activation, translocation and oligomerization of BAX", "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "Transcriptional regulation by RUNX2", "NTRK3 as a dependence receptor"], "Q07817": ["BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "Interleukin-4 and Interleukin-13 signaling", "The NLRP1 inflammasome"], "Q07820": ["Interleukin-4 and Interleukin-13 signaling"], "Q07837": ["Amino acid transport across the plasma membrane", "Defective SLC3A1 causes cystinuria (CSNU)"], "Q07864": ["Recognition of DNA damage by PCNA-containing replication complex", "Telomere C-strand synthesis initiation", "PCNA-Dependent Long Patch Base Excision Repair", "Termination of translesion DNA synthesis", "HDR through Homologous Recombination (HRR)", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "DNA replication initiation", "Activation of the pre-replicative complex"], "Q07866": ["MHC class II antigen presentation", "RHO GTPases activate KTN1", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "Q07869": ["RORA activates gene expression", "BMAL1:CLOCK,NPAS2 activates circadian gene expression", "PPARA activates gene expression", "PPARA activates gene expression", "Transcriptional activation of mitochondrial biogenesis", "Activation of gene expression by SREBF (SREBP)", "Transcriptional regulation of white adipocyte differentiation", "Nuclear Receptor transcription pathway", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)", "Circadian Clock", "SUMOylation of intracellular receptors"], "Q07889": ["SOS-mediated signalling", "SOS-mediated signalling", "Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "SHC1 events in ERBB2 signaling", "SHC1 events in ERBB4 signaling", "Signaling by SCF-KIT", "Regulation of KIT signaling", "Signalling to RAS", "Signalling to RAS", "GRB2 events in EGFR signaling", "SHC1 events in EGFR signaling", "Downstream signal transduction", "NRAGE signals death through JNK", "Rho GTPase cycle", "GRB2 events in ERBB2 signaling", "GRB2 events in ERBB2 signaling", "Tie2 Signaling", "EGFR Transactivation by Gastrin", "DAP12 signaling", "SHC-related events triggered by IGF1R", "SHC-related events triggered by IGF1R", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "GRB2:SOS provides linkage to MAPK signaling for Integrins ", "NCAM signaling for neurite out-growth", "G alpha (12/13) signalling events", "Activation of RAC1", "Constitutive Signaling by EGFRvIII", "SHC-mediated cascade:FGFR1", "FRS-mediated FGFR1 signaling", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "Signaling by FGFR2 in disease", "Signaling by FGFR4 in disease", "Signaling by FGFR1 in disease", "RAF/MAP kinase cascade", "Signal attenuation", "Insulin receptor signalling cascade", "Insulin receptor signalling cascade", "MET activates RAS signaling", "Signaling by FGFR3 fusions in cancer", "Signaling by FGFR3 point mutants in cancer", "RET signaling", "Interleukin-15 signaling", "Activated NTRK2 signals through RAS", "Erythropoietin activates RAS", "Activated NTRK2 signals through FRS2 and FRS3", "Activated NTRK2 signals through FRS2 and FRS3", "Activated NTRK3 signals through RAS", "Interleukin receptor SHC signaling", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "Q07890": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events", "Activation of RAC1", "Interleukin-15 signaling"], "Q07954": ["Scavenging of heme from plasma", "Retinoid metabolism and transport"], "Q07955": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "mRNA 3'-end processing"], "Q07960": ["Rho GTPase cycle"], "Q07973": ["Vitamin D (calciferol) metabolism", "Vitamins", "Defective CYP24A1 causes Hypercalcemia, infantile (HCAI)"], "Q08043": ["Nephrin family interactions", "Striated Muscle Contraction"], "Q08050": ["Polo-like kinase mediated events", "Cyclin A/B1/B2 associated events during G2/M transition"], "Q08116": ["G alpha (q) signalling events", "G alpha (i) signalling events", "G alpha (i) signalling events"], "Q08117": ["Repression of WNT target genes"], "Q08170": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing"], "Q08209": ["DARPP-32 events", "Calcineurin activates NFAT", "Calcineurin activates NFAT", "FCERI mediated Ca+2 mobilization", "Ca2+ pathway", "CLEC7A (Dectin-1) induces NFAT activation"], "Q08211": ["RIP-mediated NFkB activation via ZBP1", "DEx/H-box helicases activate type I IFN and inflammatory cytokines production ", "mRNA Splicing - Major Pathway"], "Q08289": ["Presynaptic depolarization and calcium channel opening", "Adrenaline,noradrenaline inhibits insulin secretion", "NCAM1 interactions", "Regulation of insulin secretion", "Regulation of insulin secretion", "Phase 0 - rapid depolarisation", "Phase 2 - plateau phase"], "Q08334": ["Other interleukin signaling", "Interleukin-10 signaling", "Interleukin-20 family signaling"], "Q08345": ["Non-integrin membrane-ECM interactions"], "Q08357": ["Sodium-coupled phosphate cotransporters", "Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1)"], "Q08379": ["Golgi Cisternae Pericentriolar Stack Reorganization", "Golgi Cisternae Pericentriolar Stack Reorganization", "COPII-mediated vesicle transport", "COPI-mediated anterograde transport", "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models"], "Q08380": ["Platelet degranulation "], "Q08397": ["Elastic fibre formation", "Crosslinking of collagen fibrils"], "Q08426": ["Beta-oxidation of very long chain fatty acids", "Peroxisomal protein import", "Peroxisomal protein import"], "Q08431": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation", "Amyloid fiber formation"], "Q08462": ["Glucagon signaling in metabolic regulation", "PKA activation", "PKA activation in glucagon signalling", "Adenylate cyclase activating pathway", "Adenylate cyclase inhibitory pathway", "Adenylate cyclase inhibitory pathway", "G alpha (s) signalling events", "G alpha (s) signalling events", "G alpha (i) signalling events", "G alpha (z) signalling events", "G alpha (z) signalling events", "Vasopressin regulates renal water homeostasis via Aquaporins", "Hedgehog 'off' state"], "Q08477": ["Fatty acids", "Miscellaneous substrates", "Eicosanoids", "Synthesis of Leukotrienes (LT) and Eoxins (EX)"], "Q08493": ["DARPP-32 events", "G alpha (s) signalling events"], "Q08495": ["Miscellaneous transport and binding events"], "Q08499": ["DARPP-32 events", "G alpha (s) signalling events"], "Q08554": ["Neutrophil degranulation", "Keratinization", "Formation of the cornified envelope"], "Q08623": ["Pyrimidine salvage"], "Q08708": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "Q08722": ["Cell surface interactions at the vascular wall", "Integrin cell surface interactions", "Signal regulatory protein family interactions", "Signal regulatory protein family interactions", "Neutrophil degranulation"], "Q08752": ["ESR-mediated signaling"], "Q08828": ["Glucagon signaling in metabolic regulation", "PKA activation", "PKA activation in glucagon signalling", "Adenylate cyclase activating pathway", "Adenylate cyclase inhibitory pathway", "Adenylate cyclase inhibitory pathway", "G alpha (s) signalling events", "G alpha (s) signalling events", "G alpha (i) signalling events", "G alpha (z) signalling events", "G alpha (z) signalling events", "Vasopressin regulates renal water homeostasis via Aquaporins", "CREB1 phosphorylation through the activation of Adenylate Cyclase", "Hedgehog 'off' state"], "Q08881": ["Generation of second messenger molecules", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization"], "Q08945": ["Formation of RNA Pol II elongation complex ", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "Regulation of TP53 Activity through Phosphorylation", "RNA Polymerase II Transcription Elongation"], "Q08999": ["Transcription of E2F targets under negative control by DREAM complex", "Transcription of E2F targets under negative control by DREAM complex", "Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1", "G0 and Early G1", "Activation of E2F1 target genes at G1/S", "Activation of E2F1 target genes at G1/S", "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "Cyclin E associated events during G1/S transition ", "Cyclin D associated events in G1", "Cyclin A:Cdk2-associated events at S phase entry", "FOXO-mediated transcription of cell cycle genes"], "Q08AG7": ["Recruitment of mitotic centrosome proteins and complexes", "Recruitment of NuMA to mitotic centrosomes"], "Q08AH1": ["Conjugation of benzoate with glycine", "Conjugation of phenylacetate with glutamine"], "Q08AH3": ["Conjugation of salicylate with glycine"], "Q08AM6": ["Synthesis of PIPs at the Golgi membrane", "Synthesis of PIPs at the Golgi membrane", "Synthesis of PIPs at the early endosome membrane", "Synthesis of PIPs at the early endosome membrane", "Synthesis of PIPs at the late endosome membrane", "Synthesis of PIPs at the late endosome membrane"], "Q08AN1": ["Generic Transcription Pathway"], "Q08ER8": ["Generic Transcription Pathway"], "Q08ET2": ["DAP12 interactions", "Neutrophil degranulation"], "Q08J23": ["tRNA modification in the nucleus and cytosol", "tRNA modification in the nucleus and cytosol"], "Q09013": ["Ion homeostasis"], "Q09028": ["Transcription of E2F targets under negative control by DREAM complex", "Transcription of E2F targets under negative control by DREAM complex", "Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1", "G0 and Early G1", "Polo-like kinase mediated events", "PRC2 methylates histones and DNA", "Oxidative Stress Induced Senescence", "HDACs deacetylate histones", "PKMTs methylate histone lysines", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "Activation of E2F1 target genes at G1/S", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Deposition of new CENPA-containing nucleosomes at the centromere", "Regulation of TP53 Activity through Acetylation", "Cyclin E associated events during G1/S transition ", "Cyclin A:Cdk2-associated events at S phase entry", "RNA Polymerase I Transcription Initiation", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription", "Transcriptional Regulation by E2F6"], "Q09160": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "Q09161": ["Cleavage of Growing Transcript in the Termination Region ", "SLBP independent Processing of Histone Pre-mRNAs", "Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Abortive elongation of HIV-1 transcript in the absence of Tat", "snRNP Assembly", "RNA Polymerase II Pre-transcription Events", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "mRNA 3'-end processing", "Processing of Capped Intron-Containing Pre-mRNA", "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "Processing of Intronless Pre-mRNAs", "Signaling by FGFR2 IIIa TM", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "Q09327": ["Reactions specific to the hybrid N-glycan synthesis pathway"], "Q09328": ["N-Glycan antennae elongation"], "Q09428": ["ATP sensitive Potassium channels", "Regulation of insulin secretion", "Defective ABCC8 can cause hypoglycemias and hyperglycemias"], "Q09470": ["Voltage gated Potassium channels"], "Q09472": ["Regulation of gene expression by Hypoxia-inducible Factor", "RORA activates gene expression", "RORA activates gene expression", "Polo-like kinase mediated events", "Pre-NOTCH Transcription and Translation", "Pre-NOTCH Transcription and Translation", "PPARA activates gene expression", "Formation of the beta-catenin:TCF transactivating complex", "Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "NOTCH1 Intracellular Domain Regulates Transcription", "NOTCH1 Intracellular Domain Regulates Transcription", "NOTCH2 intracellular domain regulates transcription", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "HATs acetylate histones", "Attenuation phase", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation", "SUMOylation of transcription cofactors", "Circadian Clock", "Circadian Clock", "B-WICH complex positively regulates rRNA expression", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "CD209 (DC-SIGN) signaling", "Metalloprotease DUBs", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "Regulation of TP53 Activity through Acetylation", "Regulation of TP53 Activity through Methylation", "PI5P Regulates TP53 Acetylation", "Activation of the TFAP2 (AP-2) family of transcription factors", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "RUNX3 regulates NOTCH signaling", "RUNX3 regulates NOTCH signaling", "Regulation of RUNX3 expression and activity", "RUNX3 regulates p14-ARF", "NOTCH3 Intracellular Domain Regulates Transcription", "NOTCH3 Intracellular Domain Regulates Transcription", "NOTCH4 Intracellular Domain Regulates Transcription", "Estrogen-dependent gene expression", "TRAF3-dependent IRF activation pathway", "TRAF6 mediated IRF7 activation", "FOXO-mediated transcription of cell death genes", "Regulation of FOXO transcriptional activity by acetylation", "Regulation of FOXO transcriptional activity by acetylation"], "Q09FC8": ["Generic Transcription Pathway"], "Q0D2K0": ["Miscellaneous transport and binding events"], "Q0IIM8": ["Golgi Associated Vesicle Biogenesis"], "Q0JRZ9": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "Q0PNE2": ["HATs acetylate histones"], "Q0VD83": ["VLDL clearance"], "Q0VDF9": ["Regulation of HSF1-mediated heat shock response"], "Q0VG06": ["Fanconi Anemia Pathway"], "Q0VGL1": ["Macroautophagy", "mTOR signalling", "mTORC1-mediated signalling", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Regulation of PTEN gene transcription"], "Q0WX57": ["Ub-specific processing proteases"], "Q0Z7S8": ["Triglyceride catabolism"], "Q10469": ["Defective MGAT2 causes MGAT2-CDG (CDG-2a)", "Reactions specific to the complex N-glycan synthesis pathway"], "Q10471": ["COPI-independent Golgi-to-ER retrograde traffic", "O-linked glycosylation of mucins"], "Q10472": ["COPI-independent Golgi-to-ER retrograde traffic", "O-linked glycosylation of mucins"], "Q10567": ["Nef mediated downregulation of MHC class I complex cell surface expression", "MHC class II antigen presentation", "Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis"], "Q10570": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA Derived from an Intronless Transcript", "tRNA processing in the nucleus", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "Q10586": ["BMAL1:CLOCK,NPAS2 activates circadian gene expression"], "Q10588": ["Post-translational modification: synthesis of GPI-anchored proteins", "Nicotinate metabolism", "Neutrophil degranulation"], "Q10589": ["Neutrophil degranulation", "Interferon alpha/beta signaling"], "Q10713": ["Mitochondrial protein import", "Processing of SMDT1"], "Q11201": ["Keratan sulfate biosynthesis", "Sialic acid metabolism", "Termination of O-glycan biosynthesis"], "Q11203": ["Pre-NOTCH Processing in Golgi", "Keratan sulfate biosynthesis", "Defective ST3GAL3 causes MCT12 and EIEE15", "Sialic acid metabolism", "Termination of O-glycan biosynthesis"], "Q11206": ["Pre-NOTCH Processing in Golgi", "Keratan sulfate biosynthesis", "Sialic acid metabolism", "N-Glycan antennae elongation", "Termination of O-glycan biosynthesis"], "Q12756": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "Q12769": ["ISG15 antiviral mechanism", "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "RHO GTPases Activate Formins", "tRNA processing in the nucleus", "Mitotic Prometaphase"], "Q12770": ["Regulation of cholesterol biosynthesis by SREBP (SREBF)", "Regulation of cholesterol biosynthesis by SREBP (SREBF)"], "Q12772": ["Regulation of cholesterol biosynthesis by SREBP (SREBF)", "Regulation of cholesterol biosynthesis by SREBP (SREBF)", "PPARA activates gene expression", "Activation of gene expression by SREBF (SREBP)", "Activation of gene expression by SREBF (SREBP)", "Transcriptional regulation of white adipocyte differentiation"], "Q12774": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "Q12778": ["AKT phosphorylates targets in the nucleus", "Regulation of gene expression in beta cells", "AKT-mediated inactivation of FOXO1A", "Constitutive Signaling by AKT1 E17K in Cancer", "MAPK6/MAPK4 signaling", "Interleukin-4 and Interleukin-13 signaling", "Regulation of localization of FOXO transcription factors", "FOXO-mediated transcription of cell death genes", "FOXO-mediated transcription of cell death genes", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "Regulation of FOXO transcriptional activity by acetylation", "Regulation of FOXO transcriptional activity by acetylation", "FOXO-mediated transcription of cell cycle genes", "FOXO-mediated transcription of cell cycle genes"], "Q12788": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "Q12789": ["RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter"], "Q12791": ["Ca2+ activated K+ channels", "cGMP effects"], "Q12794": ["CS/DS degradation", "Hyaluronan uptake and degradation", "MPS IX - Natowicz syndrome"], "Q12797": ["Stimuli-sensing channels", "Ion homeostasis"], "Q12802": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "Q12805": ["Molecules associated with elastic fibres", "Molecules associated with elastic fibres"], "Q12809": ["Voltage gated Potassium channels", "Phase 3 - rapid repolarisation"], "Q12824": ["RMTs methylate histone arginines", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "Q12829": ["RAB geranylgeranylation"], "Q12834": ["Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components", "Inactivation of APC/C via direct inhibition of the APC/C complex", "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "APC/C:Cdc20 mediated degradation of Cyclin B", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of Emi1", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Ub-specific processing proteases", "Mitotic Prometaphase", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q12836": ["Interaction With The Zona Pellucida"], "Q12837": ["Regulation of TP53 Activity through Association with Co-factors"], "Q12840": ["MHC class II antigen presentation", "Insulin processing", "RHO GTPases activate KTN1", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "Q12841": ["Signaling by BMP", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "Q12846": ["Disinhibition of SNARE formation", "ER-Phagosome pathway", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Clathrin derived vesicle budding", "Other interleukin signaling"], "Q12849": ["Viral mRNA Translation"], "Q12857": ["RNA Polymerase III Transcription Termination", "RNA Polymerase III Abortive And Retractive Initiation"], "Q12860": ["Activated NOTCH1 Transmits Signal to the Nucleus", "NOTCH2 Activation and Transmission of Signal to the Nucleus", "L1CAM interactions", "Neurofascin interactions"], "Q12864": ["Adherens junctions interactions"], "Q12866": ["Cell surface interactions at the vascular wall"], "Q12873": ["HDACs deacetylate histones", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "SUMOylation of chromatin organization proteins", "Regulation of TP53 Activity through Acetylation", "RNA Polymerase I Transcription Initiation", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription"], "Q12874": ["mRNA Splicing - Major Pathway"], "Q12879": ["Unblocking of NMDA receptors, glutamate binding and activation", "Unblocking of NMDA receptors, glutamate binding and activation", "Neurexins and neuroligins", "Synaptic adhesion-like molecules", "MECP2 regulates neuronal receptors and channels", "Negative regulation of NMDA receptor-mediated neuronal transmission", "Long-term potentiation"], "Q12882": ["Pyrimidine catabolism"], "Q12887": ["Heme biosynthesis"], "Q12888": ["SUMOylation of transcription factors", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "G2/M DNA damage checkpoint"], "Q12889": ["Interaction With The Zona Pellucida"], "Q12891": ["Hyaluronan uptake and degradation"], "Q12893": ["COPI-mediated anterograde transport"], "Q12899": ["Interferon gamma signaling"], "Q12901": ["Generic Transcription Pathway"], "Q12904": ["SeMet incorporation into proteins", "Cytosolic tRNA aminoacylation"], "Q12905": ["Neutrophil degranulation"], "Q12907": ["COPII-mediated vesicle transport", "Cargo concentration in the ER"], "Q12908": ["Recycling of bile acids and salts"], "Q12912": ["Neutrophil degranulation"], "Q12913": ["Phosphorylation of CD3 and TCR zeta chains", "Neutrophil degranulation", "Negative regulation of MET activity"], "Q12918": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "Q12923": ["Synthesis of PIPs at the plasma membrane", "Interleukin-37 signaling"], "Q12926": ["mRNA Splicing - Major Pathway"], "Q12931": ["Respiratory electron transport"], "Q12933": ["Caspase activation via Death Receptors in the presence of ligand", "Regulation by c-FLIP", "RIPK1-mediated regulated necrosis", "CASP8 activity is inhibited", "TNFR1-induced proapoptotic signaling", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "TNFR2 non-canonical NF-kB pathway", "Regulation of necroptotic cell death", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "Ub-specific processing proteases", "Dimerization of procaspase-8", "TNF signaling", "TRAF6 mediated IRF7 activation", "TRAF6 mediated NF-kB activation", "TRAF6 mediated NF-kB activation"], "Q12955": ["Interaction between L1 and Ankyrins", "Interaction between L1 and Ankyrins", "COPI-mediated anterograde transport"], "Q12959": ["Trafficking of AMPA receptors", "Unblocking of NMDA receptors, glutamate binding and activation", "Unblocking of NMDA receptors, glutamate binding and activation", "Ras activation upon Ca2+ influx through NMDA receptor", "NrCAM interactions", "Activation of Ca-permeable Kainate Receptor", "RAF/MAP kinase cascade", "Synaptic adhesion-like molecules", "Negative regulation of NMDA receptor-mediated neuronal transmission", "Long-term potentiation"], "Q12962": ["HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "HATs acetylate histones", "Ub-specific processing proteases", "RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "Q12967": ["p38MAPK events", "p38MAPK events"], "Q12968": ["Calcineurin activates NFAT", "Calcineurin activates NFAT", "FCERI mediated Ca+2 mobilization", "CLEC7A (Dectin-1) induces NFAT activation"], "Q12974": ["RAB geranylgeranylation"], "Q12979": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "Q12981": ["COPI-dependent Golgi-to-ER retrograde traffic"], "Q12982": ["CDO in myogenesis", "CDO in myogenesis"], "Q12996": ["Cleavage of Growing Transcript in the Termination Region ", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "Q13002": ["Activation of Na-permeable kainate receptors", "Activation of Ca-permeable Kainate Receptor"], "Q13003": ["Activation of Ca-permeable Kainate Receptor", "Presynaptic function of Kainate receptors"], "Q13007": ["Interleukin-20 family signaling"], "Q13009": ["NRAGE signals death through JNK", "Rho GTPase cycle", "EPHB-mediated forward signaling", "EPH-ephrin mediated repulsion of cells", "G alpha (12/13) signalling events", "Activated NTRK2 signals through CDK5"], "Q13011": ["Peroxisomal protein import", "Peroxisomal protein import"], "Q13017": ["Rho GTPase cycle"], "Q13018": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PS", "Acyl chain remodelling of PE", "Acyl chain remodelling of PI", "Acyl chain remodelling of PG", "Synthesis of PA"], "Q13042": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q13043": ["Signaling by Hippo"], "Q13046": ["Cell surface interactions at the vascular wall"], "Q13049": ["Regulation of innate immune responses to cytosolic DNA", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q13057": ["Coenzyme A biosynthesis"], "Q13061": ["Stimuli-sensing channels", "Ion homeostasis"], "Q13077": ["Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway"], "Q13084": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q13085": ["ChREBP activates metabolic gene expression", "Biotin transport and metabolism", "Import of palmitoyl-CoA into the mitochondrial matrix", "Activation of gene expression by SREBF (SREBP)", "Defective HLCS causes multiple carboxylase deficiency", "Fatty acyl-CoA biosynthesis"], "Q13093": ["Synthesis, secretion, and deacylation of Ghrelin"], "Q13094": ["GPVI-mediated activation cascade", "Generation of second messenger molecules", "Generation of second messenger molecules", "DAP12 signaling", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization"], "Q13098": ["DNA Damage Recognition in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Cargo recognition for clathrin-mediated endocytosis", "Neddylation"], "Q13099": ["Hedgehog 'off' state", "Intraflagellar transport", "Intraflagellar transport"], "Q13103": ["Platelet degranulation ", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "Q13105": ["XBP1(S) activates chaperone genes"], "Q13106": ["Generic Transcription Pathway"], "Q13107": ["TNFR1-induced proapoptotic signaling", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "Ub-specific processing proteases"], "Q13114": ["TRAF3 deficiency - HSE", "TNFR2 non-canonical NF-kB pathway", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "Ovarian tumor domain proteases", "TICAM1-dependent activation of IRF3/IRF7", "TRAF3-dependent IRF activation pathway", "Negative regulators of DDX58/IFIH1 signaling", "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon"], "Q13115": ["RAF-independent MAPK1/3 activation", "ERKs are inactivated", "Negative regulation of MAPK pathway"], "Q13126": ["Methionine salvage pathway", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "Q13127": ["HDACs deacetylate histones", "Regulation of PTEN gene transcription"], "Q13131": ["Macroautophagy", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Regulation of TP53 Activity through Phosphorylation", "Activation of AMPK downstream of NMDARs"], "Q13133": ["PPARA activates gene expression", "VLDLR internalisation and degradation"], "Q13133-1": ["Nuclear Receptor transcription pathway", "SUMOylation of intracellular receptors"], "Q13133-2": ["Nuclear Receptor transcription pathway"], "Q13136": ["Serotonin Neurotransmitter Release Cycle", "Norepinephrine Neurotransmitter Release Cycle", "Glutamate Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle", "Acetylcholine Neurotransmitter Release Cycle", "Receptor-type tyrosine-protein phosphatases"], "Q13144": ["Recycling of eIF2:GDP"], "Q13145": ["Downregulation of TGF-beta receptor signaling"], "Q13151": ["mRNA Splicing - Major Pathway", "Processing of Capped Intron-Containing Pre-mRNA"], "Q13153": ["Generation of second messenger molecules", "Regulation of actin dynamics for phagocytic cup formation", "FCERI mediated MAPK activation", "FCERI mediated MAPK activation", "DSCAM interactions", "CD28 dependent Vav1 pathway", "EPHB-mediated forward signaling", "Ephrin signaling", "Sema3A PAK dependent Axon repulsion", "Activation of RAC1", "Signal transduction by L1", "Smooth Muscle Contraction", "VEGFR2 mediated vascular permeability", "CD209 (DC-SIGN) signaling", "RHO GTPases activate PKNs", "RHO GTPases Activate ROCKs", "RHO GTPases activate PAKs", "RHO GTPases activate PAKs", "MAPK6/MAPK4 signaling", "G beta:gamma signalling through CDC42"], "Q13155": ["SeMet incorporation into proteins", "Cytosolic tRNA aminoacylation"], "Q13156": ["Activation of the pre-replicative complex"], "Q13158": ["Caspase activation via Death Receptors in the presence of ligand", "TRIF-mediated programmed cell death", "Regulation by c-FLIP", "RIPK1-mediated regulated necrosis", "CASP8 activity is inhibited", "TNFR1-induced proapoptotic signaling", "Dimerization of procaspase-8", "FasL/ CD95L signaling", "TRAIL signaling", "TLR3-mediated TICAM1-dependent programmed cell death", "NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10"], "Q13162": ["Neutrophil degranulation"], "Q13163": ["Signalling to ERK5"], "Q13164": ["ERK/MAPK targets", "ERK/MAPK targets", "Signalling to ERK5", "Signalling to ERK5", "ERKs are inactivated", "Senescence-Associated Secretory Phenotype (SASP)", "Gastrin-CREB signalling pathway via PKC and MAPK", "RET signaling"], "Q13177": ["Nef and signal transduction", "Generation of second messenger molecules", "Regulation of PAK-2p34 activity by PS-GAP/RHG10", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Stimulation of the cell death response by PAK-2p34", "FCERI mediated MAPK activation", "FCERI mediated MAPK activation", "CD28 dependent Vav1 pathway", "Ephrin signaling", "Sema3A PAK dependent Axon repulsion", "Activation of RAC1", "VEGFA-VEGFR2 Pathway", "Smooth Muscle Contraction", "VEGFR2 mediated vascular permeability", "CD209 (DC-SIGN) signaling", "RHO GTPases activate PAKs", "RHO GTPases activate PAKs", "MAPK6/MAPK4 signaling", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "Q13183": ["Sodium-coupled sulphate, di- and tri-carboxylate transporters"], "Q13185": ["ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "RNA Polymerase I Chain Elongation", "Transcriptional Regulation by E2F6"], "Q13188": ["Signaling by Hippo"], "Q13190": ["COPII-mediated vesicle transport", "Cargo concentration in the ER", "COPI-mediated anterograde transport", "Intra-Golgi traffic"], "Q13191": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q13200": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "Neutrophil degranulation", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q13201": ["Platelet degranulation "], "Q13202": ["RAF-independent MAPK1/3 activation", "Negative regulation of MAPK pathway"], "Q13216": ["Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Neddylation"], "Q13217": ["Viral mRNA Translation", "XBP1(S) activates chaperone genes", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Neutrophil degranulation", "Post-translational protein phosphorylation"], "Q13219": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "Q13224": ["EPHB-mediated forward signaling", "EPHB-mediated forward signaling", "Unblocking of NMDA receptors, glutamate binding and activation", "Unblocking of NMDA receptors, glutamate binding and activation", "Ras activation upon Ca2+ influx through NMDA receptor", "RAF/MAP kinase cascade", "Neurexins and neuroligins", "Synaptic adhesion-like molecules", "MECP2 regulates neuronal receptors and channels", "Activated NTRK2 signals through FYN", "Negative regulation of NMDA receptor-mediated neuronal transmission", "Long-term potentiation"], "Q13227": ["PPARA activates gene expression", "HDACs deacetylate histones", "Loss of MECP2 binding ability to the NCoR/SMRT complex", "Regulation of MECP2 expression and activity"], "Q13231": ["Digestion of dietary carbohydrate", "Neutrophil degranulation"], "Q13232": ["Interconversion of nucleotide di- and triphosphates"], "Q13233": ["MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "FCERI mediated MAPK activation", "FCERI mediated MAPK activation", "TRAF6 mediated NF-kB activation", "TRAF6 mediated NF-kB activation", "TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "MyD88 cascade initiated on plasma membrane"], "Q13237": ["Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "Ca2+ pathway", "cGMP effects", "cGMP effects"], "Q13241": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "DAP12 interactions", "DAP12 signaling", "DAP12 signaling"], "Q13242": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing"], "Q13243": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing"], "Q13247": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "mRNA 3'-end processing"], "Q13253": ["Signaling by BMP"], "Q13255": ["G alpha (q) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)", "Neurexins and neuroligins", "Neurexins and neuroligins"], "Q13257": ["Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components", "Inactivation of APC/C via direct inhibition of the APC/C complex", "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "APC/C:Cdc20 mediated degradation of mitotic proteins", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "Q13258": ["Prostanoid ligand receptors", "G alpha (s) signalling events"], "Q13261": ["Interleukin-15 signaling", "Interleukin-15 signaling"], "Q13263": ["Generic Transcription Pathway", "SUMOylation of transcription cofactors"], "Q13277": ["Other interleukin signaling"], "Q13285": ["Nuclear Receptor transcription pathway", "SUMOylation of intracellular receptors", "Transcriptional regulation of pluripotent stem cells"], "Q13303": ["Voltage gated Potassium channels", "Neutrophil degranulation"], "Q13304": ["Leukotriene receptors", "G alpha (q) signalling events", "P2Y receptors", "G alpha (i) signalling events"], "Q13309": ["APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "SCF(Skp2)-mediated degradation of p27/p21", "Ub-specific processing proteases", "Orc1 removal from chromatin", "Cyclin D associated events in G1", "Regulation of RUNX2 expression and activity", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q13315": ["DNA Damage/Telomere Stress Induced Senescence", "Regulation of HSF1-mediated heat shock response", "Autodegradation of the E3 ubiquitin ligase COP1", "HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Sensing of DNA Double Strand Breaks", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Nonhomologous End-Joining (NHEJ)", "Homologous DNA Pairing and Strand Exchange", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "TP53 Regulates Transcription of DNA Repair Genes", "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "TP53 Regulates Transcription of Caspase Activators and Caspases", "Regulation of TP53 Activity through Phosphorylation", "Regulation of TP53 Degradation", "Regulation of TP53 Activity through Methylation", "G2/M DNA damage checkpoint", "Stabilization of p53", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "Meiotic recombination"], "Q13316": ["ECM proteoglycans", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "Q13322": ["Signaling by SCF-KIT", "IRS activation", "Signal attenuation", "Insulin receptor signalling cascade", "RET signaling"], "Q13324": ["G alpha (s) signalling events", "Synthesis, secretion, and deacylation of Ghrelin"], "Q13324-1": ["Class B/2 (Secretin family receptors)"], "Q13324-2": ["Class B/2 (Secretin family receptors)"], "Q13330": ["HDACs deacetylate histones", "SUMOylation of transcription factors", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "RNA Polymerase I Transcription Initiation", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription"], "Q13332": ["ECM proteoglycans", "Receptor-type tyrosine-protein phosphatases", "Synaptic adhesion-like molecules", "Signaling by NTRK3 (TRKC)"], "Q13336": ["Transport of bile salts and organic acids, metal ions and amine compounds"], "Q13347": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "Q13349": ["Integrin cell surface interactions"], "Q13352": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "NRIF signals cell death from the nucleus", "NRIF signals cell death from the nucleus", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Deposition of new CENPA-containing nucleosomes at the centromere", "Mitotic Prometaphase"], "Q13356": ["Basigin interactions"], "Q13361": ["Elastic fibre formation", "Molecules associated with elastic fibres", "Molecules associated with elastic fibres"], "Q13362": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Degradation of beta-catenin by the destruction complex", "Beta-catenin phosphorylation cascade", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "CTLA4 inhibitory signaling", "Platelet sensitization by LDL", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Misspliced GSK3beta mutants stabilize beta-catenin", "S33 mutants of beta-catenin aren't phosphorylated", "S37 mutants of beta-catenin aren't phosphorylated", "S45 mutants of beta-catenin aren't phosphorylated", "T41 mutants of beta-catenin aren't phosphorylated", "APC truncation mutants have impaired AXIN binding", "AXIN missense mutants destabilize the destruction complex", "Truncations of AMER1 destabilize the destruction complex", "RHO GTPases Activate Formins", "RAF activation", "Negative regulation of MAPK pathway", "Regulation of TP53 Degradation", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Mitotic Prometaphase"], "Q13363": ["Deactivation of the beta-catenin transactivating complex", "SUMOylation of transcription cofactors", "Repression of WNT target genes", "TCF7L2 mutants don't bind CTBP"], "Q13370": ["PDE3B signalling", "PDE3B signalling", "cGMP effects", "G alpha (s) signalling events"], "Q13371": ["Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "Q13393": ["Synthesis of PG", "Synthesis of PA", "Role of phospholipids in phagocytosis", "Neutrophil degranulation"], "Q13398": ["Generic Transcription Pathway"], "Q13402": ["The canonical retinoid cycle in rods (twilight vision)"], "Q13404": ["NOD1/2 Signaling Pathway", "TICAM1, RIP1-mediated IKK complex recruitment ", "Downstream TCR signaling", "FCERI mediated NF-kB activation", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "activated TAK1 mediates p38 MAPK activation", "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "CLEC7A (Dectin-1) signaling", "Interleukin-1 signaling", "IRAK1 recruits IKK complex", "IKK complex recruitment mediated by RIP1", "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q13405": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q13409": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Regulation of PLK1 Activity at G2/M Transition", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "AURKA Activation by TPX2"], "Q13410": ["Butyrophilin (BTN) family interactions"], "Q13415": ["E2F-enabled inhibition of pre-replication complex formation", "Activation of ATR in response to replication stress", "Activation of E2F1 target genes at G1/S", "Assembly of the ORC complex at the origin of replication", "CDC6 association with the ORC:origin complex", "CDT1 association with the CDC6:ORC:origin complex", "Assembly of the pre-replicative complex", "Orc1 removal from chromatin", "Activation of the pre-replicative complex"], "Q13416": ["E2F-enabled inhibition of pre-replication complex formation", "Activation of ATR in response to replication stress", "Assembly of the ORC complex at the origin of replication", "CDC6 association with the ORC:origin complex", "CDT1 association with the CDC6:ORC:origin complex", "Assembly of the pre-replicative complex", "Orc1 removal from chromatin", "Activation of the pre-replicative complex"], "Q13418": ["Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "Cell-extracellular matrix interactions"], "Q13421": ["Post-translational modification: synthesis of GPI-anchored proteins", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "Q13422-1": ["NOTCH3 Intracellular Domain Regulates Transcription"], "Q13423": ["Citric acid cycle (TCA cycle)"], "Q13426": ["2-LTR circle formation", "SUMOylation of DNA damage response and repair proteins", "Nonhomologous End-Joining (NHEJ)"], "Q13433": ["Zinc influx into cells by the SLC39 gene family"], "Q13435": ["mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "Q13438": ["ABC-family proteins mediated transport", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Defective CFTR causes cystic fibrosis", "ER Quality Control Compartment (ERQC)"], "Q13439": ["Retrograde transport at the Trans-Golgi-Network"], "Q13442": ["Neutrophil degranulation"], "Q13443": ["Collagen degradation"], "Q13444": ["Degradation of the extracellular matrix", "Invadopodia formation"], "Q13449": ["Post-translational modification: synthesis of GPI-anchored proteins"], "Q13451": ["HSP90 chaperone cycle for steroid hormone receptors (SHR)", "ESR-mediated signaling", "MECP2 regulates neuronal receptors and channels"], "Q13454": ["Asparagine N-linked glycosylation", "Miscellaneous transport and binding events"], "Q13459": ["Rho GTPase cycle", "Regulation of actin dynamics for phagocytic cup formation", "SLIT2:ROBO1 increases RHOA activity"], "Q13464": ["Apoptotic cleavage of cellular proteins", "EPHB-mediated forward signaling", "EPHB-mediated forward signaling", "EPHA-mediated growth cone collapse", "G alpha (12/13) signalling events", "Sema4D induced cell migration and growth-cone collapse", "Sema4D induced cell migration and growth-cone collapse", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate ROCKs", "RHO GTPases Activate ROCKs", "Neutrophil degranulation"], "Q13467": ["Class B/2 (Secretin family receptors)", "Ca2+ pathway", "Ca2+ pathway", "Asymmetric localization of PCP proteins", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Regulation of FZD by ubiquitination", "WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "RNF mutants show enhanced WNT signaling and proliferation"], "Q13469": ["Calcineurin activates NFAT", "Calcineurin activates NFAT", "FCERI mediated Ca+2 mobilization", "CLEC7A (Dectin-1) induces NFAT activation", "RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)"], "Q13472": ["HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Regulation of TP53 Activity through Phosphorylation", "G2/M DNA damage checkpoint", "Meiotic recombination"], "Q13477-1": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Integrin cell surface interactions"], "Q13478": ["Interleukin-37 signaling", "Interleukin-18 signaling"], "Q13480": ["PI3K Cascade", "Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "PIP3 activates AKT signaling", "GAB1 signalosome", "PI3K events in ERBB2 signaling", "Constitutive Signaling by Aberrant PI3K in Cancer", "Constitutive Signaling by EGFRvIII", "PI-3K cascade:FGFR1", "PI-3K cascade:FGFR2", "PI-3K cascade:FGFR3", "PI-3K cascade:FGFR4", "Signaling by FGFR2 in disease", "Signaling by FGFR4 in disease", "Signaling by FGFR1 in disease", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "MET activates PI3K/AKT signaling", "Signaling by FGFR3 fusions in cancer", "Signaling by FGFR3 point mutants in cancer", "RET signaling", "MET activates PTPN11", "MET activates RAP1 and RAC1", "MET receptor recycling", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "Activated NTRK2 signals through PI3K"], "Q13485": ["Signaling by NODAL", "Signaling by Activin", "Signaling by BMP", "TGF-beta receptor signaling activates SMADs", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "SMAD4 MH2 Domain Mutants in Cancer", "SMAD2/3 MH2 Domain Mutants in Cancer", "Transcriptional regulation of pluripotent stem cells", "Ub-specific processing proteases", "RUNX2 regulates bone development", "RUNX3 regulates CDKN1A transcription", "RUNX3 regulates BCL2L11 (BIM) transcription", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "FOXO-mediated transcription of cell cycle genes", "FOXO-mediated transcription of cell cycle genes"], "Q13487": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "Q13488": ["ROS, RNS production in phagocytes", "Neutrophil degranulation", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "Q13489": ["NOD1/2 Signaling Pathway", "TICAM1, RIP1-mediated IKK complex recruitment ", "RIPK1-mediated regulated necrosis", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "TNFR2 non-canonical NF-kB pathway", "Regulation of necroptotic cell death", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "Ub-specific processing proteases", "IKK complex recruitment mediated by RIP1"], "Q13490": ["Apoptotic cleavage of cellular proteins", "NOD1/2 Signaling Pathway", "TICAM1, RIP1-mediated IKK complex recruitment ", "RIPK1-mediated regulated necrosis", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "TNFR2 non-canonical NF-kB pathway", "Regulation of necroptotic cell death", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "Ub-specific processing proteases", "IKK complex recruitment mediated by RIP1"], "Q13492": ["Golgi Associated Vesicle Biogenesis", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "Q13495": ["Pre-NOTCH Transcription and Translation", "Pre-NOTCH Transcription and Translation", "Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "NOTCH1 Intracellular Domain Regulates Transcription", "NOTCH1 Intracellular Domain Regulates Transcription", "NOTCH2 intracellular domain regulates transcription", "NOTCH2 intracellular domain regulates transcription", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "Notch-HLH transcription pathway", "RUNX3 regulates NOTCH signaling", "RUNX3 regulates NOTCH signaling", "NOTCH3 Intracellular Domain Regulates Transcription", "NOTCH3 Intracellular Domain Regulates Transcription", "NOTCH4 Intracellular Domain Regulates Transcription", "NOTCH4 Intracellular Domain Regulates Transcription"], "Q13496": ["Synthesis of PIPs at the plasma membrane", "Synthesis of PIPs at the early endosome membrane", "Synthesis of PIPs at the late endosome membrane"], "Q13501": ["NRIF signals cell death from the nucleus", "p75NTR recruits signalling complexes", "NF-kB is activated and signals survival", "Pink/Parkin Mediated Mitophagy", "Interleukin-1 signaling"], "Q13503": ["PPARA activates gene expression", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "Q13505": ["Mitochondrial protein import", "Cristae formation"], "Q13507": ["Effects of PIP2 hydrolysis", "Elevation of cytosolic Ca2+ levels", "TRP channels", "Role of second messengers in netrin-1 signaling", "MECP2 regulates neuronal receptors and channels"], "Q13508": ["Post-translational modification: synthesis of GPI-anchored proteins"], "Q13509": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "Gap junction assembly", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Recruitment of NuMA to mitotic centrosomes", "Prefoldin mediated transfer of substrate to CCT/TriC", "Formation of tubulin folding intermediates by CCT/TriC", "Post-chaperonin tubulin folding pathway", "Recycling pathway of L1", "Recycling pathway of L1", "Hedgehog 'off' state", "Cilium Assembly", "Intraflagellar transport", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "Carboxyterminal post-translational modifications of tubulin", "Carboxyterminal post-translational modifications of tubulin", "Activation of AMPK downstream of NMDARs", "Kinesins"], "Q13510": ["Glycosphingolipid metabolism", "Neutrophil degranulation"], "Q13519": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "Q13520": ["Passive transport by Aquaporins"], "Q13526": ["ISG15 antiviral mechanism", "RHO GTPases Activate NADPH Oxidases", "Regulation of TP53 Activity through Phosphorylation", "PI5P Regulates TP53 Acetylation", "Negative regulators of DDX58/IFIH1 signaling"], "Q13530": ["Serine biosynthesis"], "Q13535": ["Meiotic synapsis", "Activation of ATR in response to replication stress", "Regulation of HSF1-mediated heat shock response", "HDR through Single Strand Annealing (SSA)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Fanconi Anemia Pathway", "TP53 Regulates Transcription of DNA Repair Genes", "Regulation of TP53 Activity through Phosphorylation", "G2/M DNA damage checkpoint"], "Q13541": ["mTORC1-mediated signalling", "Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S"], "Q13546": ["Caspase activation via Death Receptors in the presence of ligand", "TICAM1, RIP1-mediated IKK complex recruitment ", "RIP-mediated NFkB activation via ZBP1", "TRIF-mediated programmed cell death", "TRP channels", "Regulation by c-FLIP", "RIPK1-mediated regulated necrosis", "CASP8 activity is inhibited", "TNFR1-induced proapoptotic signaling", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "Regulation of necroptotic cell death", "Ub-specific processing proteases", "Ovarian tumor domain proteases", "Dimerization of procaspase-8", "TNF signaling", "TLR3-mediated TICAM1-dependent programmed cell death", "NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10", "IKK complex recruitment mediated by RIP1"], "Q13547": ["Transcription of E2F targets under negative control by DREAM complex", "Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1", "G0 and Early G1", "p75NTR negatively regulates cell cycle via SC1", "Formation of the beta-catenin:TCF transactivating complex", "NOTCH1 Intracellular Domain Regulates Transcription", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "HDACs deacetylate histones", "Deactivation of the beta-catenin transactivating complex", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "SUMOylation of chromatin organization proteins", "Repression of WNT target genes", "Repression of WNT target genes", "Activation of E2F1 target genes at G1/S", "Regulation of TP53 Activity through Acetylation", "RNA Polymerase I Transcription Initiation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription", "Estrogen-dependent gene expression", "Loss of MECP2 binding ability to 5mC-DNA", "Regulation of MECP2 expression and activity", "MECP2 regulates neuronal receptors and channels", "MECP2 regulates transcription of neuronal ligands", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "Factors involved in megakaryocyte development and platelet production"], "Q13554": ["CaMK IV-mediated phosphorylation of CREB", "HSF1-dependent transactivation", "Trafficking of AMPA receptors", "Unblocking of NMDA receptors, glutamate binding and activation", "CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "Phase 0 - rapid depolarisation", "Ion homeostasis", "RAF activation", "Signaling by moderate kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF", "Interferon gamma signaling", "Regulation of MECP2 expression and activity", "Ion transport by P-type ATPases", "Negative regulation of NMDA receptor-mediated neuronal transmission", "Long-term potentiation"], "Q13555": ["CaMK IV-mediated phosphorylation of CREB", "HSF1-dependent transactivation", "Trafficking of AMPA receptors", "Unblocking of NMDA receptors, glutamate binding and activation", "CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "Phase 0 - rapid depolarisation", "Ion homeostasis", "RAF activation", "Signaling by moderate kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF", "Interferon gamma signaling", "Regulation of MECP2 expression and activity", "Ion transport by P-type ATPases", "Negative regulation of NMDA receptor-mediated neuronal transmission", "Long-term potentiation"], "Q13557": ["CaMK IV-mediated phosphorylation of CREB", "HSF1-dependent transactivation", "Trafficking of AMPA receptors", "Unblocking of NMDA receptors, glutamate binding and activation", "Phase 0 - rapid depolarisation", "Ion homeostasis", "RAF activation", "Signaling by moderate kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF", "Interferon gamma signaling", "Regulation of MECP2 expression and activity", "Ion transport by P-type ATPases", "Negative regulation of NMDA receptor-mediated neuronal transmission", "Long-term potentiation"], "Q13561": ["MHC class II antigen presentation", "Regulation of PLK1 Activity at G2/M Transition", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic", "AURKA Activation by TPX2"], "Q13562": ["Regulation of gene expression in beta cells", "Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells"], "Q13563": ["VxPx cargo-targeting to cilium", "VxPx cargo-targeting to cilium"], "Q13564": ["Neddylation"], "Q13568": ["Interferon gamma signaling", "Interferon alpha/beta signaling"], "Q13569": ["Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "Cleavage of the damaged pyrimidine ", "Displacement of DNA glycosylase by APEX1", "SUMOylation of DNA damage response and repair proteins", "TET1,2,3 and TDG demethylate DNA"], "Q13572": ["Synthesis of pyrophosphates in the cytosol", "Synthesis of IP3 and IP4 in the cytosol", "Factors involved in megakaryocyte development and platelet production"], "Q13573": ["Pre-NOTCH Transcription and Translation", "Pre-NOTCH Transcription and Translation", "Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "NOTCH1 Intracellular Domain Regulates Transcription", "NOTCH1 Intracellular Domain Regulates Transcription", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "Notch-HLH transcription pathway", "mRNA Splicing - Major Pathway", "RUNX3 regulates NOTCH signaling", "RUNX3 regulates NOTCH signaling", "NOTCH3 Intracellular Domain Regulates Transcription", "NOTCH3 Intracellular Domain Regulates Transcription", "NOTCH4 Intracellular Domain Regulates Transcription"], "Q13574": ["Effects of PIP2 hydrolysis"], "Q13576": ["RHO GTPases activate IQGAPs", "Neutrophil degranulation"], "Q13586": ["Elevation of cytosolic Ca2+ levels", "Ion homeostasis", "Ion homeostasis", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "Q13588": ["Signaling by SCF-KIT"], "Q13591": ["Other semaphorin interactions", "Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "Q13601": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "Q13606": ["Olfactory Signaling Pathway"], "Q13607": ["Olfactory Signaling Pathway"], "Q13608": ["Peroxisomal protein import", "Peroxisomal protein import"], "Q13613": ["Synthesis of PIPs at the plasma membrane"], "Q13614": ["Synthesis of PIPs at the ER membrane", "Synthesis of PIPs at the plasma membrane", "Synthesis of PIPs at the early endosome membrane", "Synthesis of PIPs at the early endosome membrane", "Synthesis of PIPs at the late endosome membrane"], "Q13615": ["Macroautophagy", "Synthesis of PIPs at the plasma membrane"], "Q13616": ["Activation of NF-kappaB in B cells", "Prolactin receptor signaling", "SCF-beta-TrCP mediated degradation of Emi1", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "NOTCH1 Intracellular Domain Regulates Transcription", "Regulation of PLK1 Activity at G2/M Transition", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling", "FCERI mediated NF-kB activation", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "Circadian Clock", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "NIK-->noncanonical NF-kB signaling", "MAP3K8 (TPL2)-dependent MAPK1/3 activation", "Orc1 removal from chromatin", "Cyclin D associated events in G1", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Neddylation", "Interleukin-1 signaling", "Iron uptake and transport", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q13617": ["Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q13618": ["Degradation of DVL", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q13619": ["Recognition of DNA damage by PCNA-containing replication complex", "DNA Damage Recognition in GG-NER", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Neddylation"], "Q13620": ["Recognition of DNA damage by PCNA-containing replication complex", "DNA Damage Recognition in GG-NER", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Neddylation"], "Q13621": ["Cation-coupled Chloride cotransporters", "Defective SLC12A1 causes Bartter syndrome 1 (BS1)"], "Q13625": ["Activation of PUMA and translocation to mitochondria", "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "TP53 Regulates Transcription of Death Receptors and Ligands", "Regulation of TP53 Activity through Association with Co-factors"], "Q13627": ["G0 and Early G1"], "Q13630": ["GDP-fucose biosynthesis"], "Q13634": ["Adherens junctions interactions"], "Q13635": ["Class B/2 (Secretin family receptors)", "Hedgehog 'off' state", "Ligand-receptor interactions", "Ligand-receptor interactions", "Hedgehog 'on' state", "Hedgehog 'on' state", "Activation of SMO"], "Q13636": ["Neutrophil degranulation", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "Q13637": ["RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "Q13639": ["Serotonin receptors", "G alpha (s) signalling events"], "Q13651": ["Interleukin-10 signaling"], "Q13671": ["RAB GEFs exchange GTP for GDP on RABs"], "Q13683": ["Integrin cell surface interactions", "Laminin interactions", "Laminin interactions", "ECM proteoglycans"], "Q13698": ["NCAM1 interactions", "Phase 0 - rapid depolarisation", "Phase 2 - plateau phase"], "Q13705": ["Signaling by NODAL", "Regulation of signaling by NODAL", "Signaling by Activin", "Signaling by Activin", "Signaling by BMP"], "Q13724": ["Defective MOGS causes MOGS-CDG (CDG-2b)", "N-glycan trimming in the ER and Calnexin/Calreticulin cycle"], "Q13733": ["Ion homeostasis", "Ion transport by P-type ATPases"], "Q13740": ["L1CAM interactions"], "Q13751": ["Degradation of the extracellular matrix", "Degradation of the extracellular matrix", "Assembly of collagen fibrils and other multimeric structures", "Anchoring fibril formation", "Laminin interactions", "Laminin interactions", "Non-integrin membrane-ECM interactions", "Type I hemidesmosome assembly", "MET activates PTK2 signaling"], "Q13753": ["Degradation of the extracellular matrix", "Degradation of the extracellular matrix", "Assembly of collagen fibrils and other multimeric structures", "Anchoring fibril formation", "Laminin interactions", "Laminin interactions", "Non-integrin membrane-ECM interactions", "Type I hemidesmosome assembly", "MET activates PTK2 signaling"], "Q13761": ["Binding of TCF/LEF:CTNNB1 to target gene promoters", "RUNX3 regulates CDKN1A transcription", "RUNX3 regulates NOTCH signaling", "Regulation of RUNX3 expression and activity", "RUNX3 Regulates Immune Response and Cell Migration", "RUNX3 Regulates Immune Response and Cell Migration", "RUNX3 regulates WNT signaling", "RUNX3 regulates YAP1-mediated transcription", "RUNX3 regulates RUNX1-mediated transcription", "RUNX3 regulates p14-ARF", "RUNX3 regulates BCL2L11 (BIM) transcription"], "Q13769": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA 3'-end processing"], "Q13790": ["LDL remodeling"], "Q13794": ["Activation of NOXA and translocation to mitochondria", "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release"], "Q13795": ["Retrograde transport at the Trans-Golgi-Network", "Retrograde transport at the Trans-Golgi-Network"], "Q13797": ["Integrin cell surface interactions", "Integrin cell surface interactions", "ECM proteoglycans", "Signal transduction by L1"], "Q13813": ["Caspase-mediated cleavage of cytoskeletal proteins", "Nephrin family interactions", "NCAM signaling for neurite out-growth", "NCAM signaling for neurite out-growth", "Interaction between L1 and Ankyrins", "Interaction between L1 and Ankyrins", "RAF/MAP kinase cascade", "Neutrophil degranulation", "COPI-mediated anterograde transport"], "Q13822": ["Vitamin B5 (pantothenate) metabolism"], "Q13825": ["Branched-chain amino acid catabolism"], "Q13835": ["Apoptotic cleavage of cell adhesion proteins", "Neutrophil degranulation", "Keratinization", "Formation of the cornified envelope"], "Q13838": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA 3'-end processing"], "Q13867": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q13868": ["ATF4 activates genes", "mRNA decay by 3' to 5' exoribonuclease", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "KSRP (KHSRP) binds and destabilizes mRNA", "Major pathway of rRNA processing in the nucleolus and cytosol"], "Q13873": ["Signaling by BMP"], "Q13875": ["Transcriptional Regulation by MECP2"], "Q13882": ["SCF(Skp2)-mediated degradation of p27/p21", "Cyclin D associated events in G1", "ERBB2 Activates PTK6 Signaling", "PTK6 Regulates Proteins Involved in RNA Processing", "PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "PTK6 Regulates Cell Cycle", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "PTK6 Down-Regulation", "PTK6 Expression", "PTK6 Activates STAT3", "PTK6 promotes HIF1A stabilization"], "Q13885": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "Gap junction assembly", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Recruitment of NuMA to mitotic centrosomes", "Prefoldin mediated transfer of substrate to CCT/TriC", "Formation of tubulin folding intermediates by CCT/TriC", "Post-chaperonin tubulin folding pathway", "Recycling pathway of L1", "Recycling pathway of L1", "Hedgehog 'off' state", "Cilium Assembly", "Intraflagellar transport", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "Carboxyterminal post-translational modifications of tubulin", "Carboxyterminal post-translational modifications of tubulin", "Activation of AMPK downstream of NMDARs", "Kinesins"], "Q13887": ["Transcriptional regulation of white adipocyte differentiation"], "Q13888": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Tat-mediated elongation of the HIV-1 transcript", "NoRC negatively regulates rRNA expression", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "mRNA Capping", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase I Transcription Termination", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE"], "Q13889": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Tat-mediated elongation of the HIV-1 transcript", "NoRC negatively regulates rRNA expression", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "mRNA Capping", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase I Transcription Termination", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE"], "Q13895": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "Q13901": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "Q13905": ["Frs2-mediated activation", "Frs2-mediated activation", "Downstream signal transduction", "MET activates RAP1 and RAC1", "Erythropoietin activates RAS", "Erythropoietin activates RAS", "Regulation of signaling by CBL"], "Q13907": ["Cholesterol biosynthesis", "Activation of gene expression by SREBF (SREBP)"], "Q13936": ["Adrenaline,noradrenaline inhibits insulin secretion", "NCAM1 interactions", "Regulation of insulin secretion", "Regulation of insulin secretion", "Phase 0 - rapid depolarisation", "Phase 2 - plateau phase"], "Q13946": ["G alpha (s) signalling events"], "Q13948": ["Intra-Golgi traffic"], "Q13950-1": ["YAP1- and WWTR1 (TAZ)-stimulated gene expression", "Transcriptional regulation by RUNX2", "Transcriptional regulation by RUNX2", "RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "RUNX2 regulates osteoblast differentiation", "RUNX2 regulates osteoblast differentiation", "RUNX2 regulates chondrocyte maturation", "RUNX2 regulates bone development", "RUNX2 regulates genes involved in cell migration", "RUNX2 regulates genes involved in cell migration", "RUNX2 regulates genes involved in differentiation of myeloid cells"], "Q13950-2": ["YAP1- and WWTR1 (TAZ)-stimulated gene expression", "Transcriptional regulation by RUNX2", "Transcriptional regulation by RUNX2", "RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "RUNX2 regulates osteoblast differentiation", "RUNX2 regulates osteoblast differentiation", "RUNX2 regulates chondrocyte maturation", "RUNX2 regulates bone development", "RUNX2 regulates genes involved in cell migration", "RUNX2 regulates genes involved in cell migration", "RUNX2 regulates genes involved in differentiation of myeloid cells"], "Q13951": ["RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "Transcriptional regulation by RUNX2", "Transcriptional regulation by RUNX2", "RUNX1 regulates estrogen receptor mediated transcription", "Regulation of RUNX1 Expression and Activity", "RUNX1 regulates expression of components of tight junctions", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "RUNX1 regulates transcription of genes involved in differentiation of keratinocytes", "RUNX1 regulates transcription of genes involved in differentiation of keratinocytes", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "RUNX1 regulates transcription of genes involved in BCR signaling", "RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "RUNX1 regulates transcription of genes involved in interleukin signaling", "RUNX1 regulates transcription of genes involved in WNT signaling", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "RUNX2 regulates osteoblast differentiation", "RUNX2 regulates osteoblast differentiation", "RUNX2 regulates chondrocyte maturation", "RUNX2 regulates bone development", "RUNX2 regulates genes involved in cell migration", "RUNX2 regulates genes involved in cell migration", "RUNX2 regulates genes involved in differentiation of myeloid cells", "Regulation of RUNX3 expression and activity", "RUNX3 Regulates Immune Response and Cell Migration", "RUNX3 Regulates Immune Response and Cell Migration", "RUNX3 regulates RUNX1-mediated transcription", "RUNX3 regulates p14-ARF", "Estrogen-dependent gene expression"], "Q13952": ["PPARA activates gene expression", "Activation of gene expression by SREBF (SREBP)", "Activation of gene expression by SREBF (SREBP)", "ATF4 activates genes", "ATF6 (ATF6-alpha) activates chaperone genes", "FOXO-mediated transcription of cell death genes"], "Q13972": ["Ras activation upon Ca2+ influx through NMDA receptor", "RAF/MAP kinase cascade"], "Q13976": ["Ca2+ pathway"], "Q13976-1": ["Rap1 signalling", "cGMP effects", "cGMP effects"], "Q14002": ["Post-translational modification: synthesis of GPI-anchored proteins"], "Q14003": ["Voltage gated Potassium channels"], "Q14004": ["TP53 Regulates Transcription of DNA Repair Genes", "Neutrophil degranulation"], "Q14005": ["Other interleukin signaling"], "Q14008": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "RHO GTPases Activate Formins", "Mitotic Prometaphase", "AURKA Activation by TPX2"], "Q14012": ["Negative regulation of NMDA receptor-mediated neuronal transmission", "Activation of RAC1 downstream of NMDARs", "Activation of RAC1 downstream of NMDARs"], "Q14019": ["Neutrophil degranulation"], "Q14028": ["Activation of the phototransduction cascade", "Inactivation, recovery and regulation of the phototransduction cascade", "VxPx cargo-targeting to cilium", "VxPx cargo-targeting to cilium"], "Q14031": ["Collagen degradation", "Collagen degradation", "Extracellular matrix organization", "Collagen biosynthesis and modifying enzymes", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "Integrin cell surface interactions", "Anchoring fibril formation", "Crosslinking of collagen fibrils", "Laminin interactions", "Laminin interactions", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "Collagen chain trimerization"], "Q14032": ["Recycling of bile acids and salts", "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Peroxisomal protein import", "Peroxisomal protein import"], "Q14050": ["Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Signaling by PDGF", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "ECM proteoglycans", "NCAM1 interactions", "Collagen chain trimerization"], "Q14055": ["Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Signaling by PDGF", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "ECM proteoglycans", "NCAM1 interactions", "Collagen chain trimerization"], "Q14061": ["Mitochondrial protein import"], "Q14088": ["TBC/RABGAPs", "RAB geranylgeranylation"], "Q14103": ["mRNA Splicing - Major Pathway", "Processing of Capped Intron-Containing Pre-mRNA"], "Q14103-3": ["AUF1 (hnRNP D0) binds and destabilizes mRNA"], "Q14103-4": ["AUF1 (hnRNP D0) binds and destabilizes mRNA"], "Q14108": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "Q14112": ["Laminin interactions", "Laminin interactions"], "Q14114": ["Platelet sensitization by LDL", "Retinoid metabolism and transport"], "Q14116": ["Interleukin-1 processing", "Interleukin-10 signaling", "Interleukin-4 and Interleukin-13 signaling", "Interleukin-18 signaling"], "Q14116-2": ["Interleukin-18 signaling"], "Q14117": ["Pyrimidine catabolism"], "Q14118": ["Non-integrin membrane-ECM interactions", "ECM proteoglycans", "ECM proteoglycans", "Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3", "Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2", "Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1", "O-linked glycosylation", "Regulation of expression of SLITs and ROBOs"], "Q14123": ["Cam-PDE 1 activation"], "Q14126": ["Apoptotic cleavage of cell adhesion proteins", "Keratinization", "Formation of the cornified envelope"], "Q14134": ["Interferon gamma signaling"], "Q14137": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "Q14139": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q14142": ["Interferon gamma signaling"], "Q14145": ["Ub-specific processing proteases", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q14152": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "Q14155": ["EGFR downregulation", "NRAGE signals death through JNK", "Rho GTPase cycle", "Ephrin signaling", "G alpha (12/13) signalling events"], "Q14155-1": ["Activation of RAC1 downstream of NMDARs"], "Q14159": ["Resolution of D-loop Structures through Holliday Junction Intermediates"], "Q14160": ["Asymmetric localization of PCP proteins"], "Q14162": ["Scavenging by Class F Receptors", "Scavenging by Class F Receptors"], "Q14164": ["SUMOylation of immune response proteins", "TICAM1-dependent activation of IRF3/IRF7", "TRAF3-dependent IRF activation pathway", "TRAF6 mediated IRF7 activation", "Negative regulators of DDX58/IFIH1 signaling", "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon"], "Q14165": ["N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "Neutrophil degranulation"], "Q14166": ["Carboxyterminal post-translational modifications of tubulin"], "Q14181": ["Inhibition of replication initiation of damaged DNA by RB1/E2F1", "Polymerase switching on the C-strand of the telomere", "Telomere C-strand synthesis initiation", "DNA replication initiation", "Activation of the pre-replicative complex", "Polymerase switching", "Removal of the Flap Intermediate", "Processive synthesis on the lagging strand"], "Q14185": ["Regulation of actin dynamics for phagocytic cup formation", "DCC mediated attractive signaling", "DCC mediated attractive signaling", "VEGFA-VEGFR2 Pathway", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "Factors involved in megakaryocyte development and platelet production"], "Q14186": ["Activation of NOXA and translocation to mitochondria", "Inhibition of replication initiation of damaged DNA by RB1/E2F1", "Transcription of E2F targets under negative control by DREAM complex", "Transcription of E2F targets under negative control by DREAM complex", "Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1", "Activation of PUMA and translocation to mitochondria", "G0 and Early G1", "Pre-NOTCH Transcription and Translation", "Pre-NOTCH Transcription and Translation", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Oxidative Stress Induced Senescence", "Oncogene Induced Senescence", "Activation of E2F1 target genes at G1/S", "Activation of E2F1 target genes at G1/S", "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "Cyclin E associated events during G1/S transition ", "Cyclin D associated events in G1", "Cyclin A:Cdk2-associated events at S phase entry", "Transcriptional Regulation by E2F6"], "Q14188": ["Activation of NOXA and translocation to mitochondria", "Inhibition of replication initiation of damaged DNA by RB1/E2F1", "Transcription of E2F targets under negative control by DREAM complex", "Transcription of E2F targets under negative control by DREAM complex", "Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1", "Activation of PUMA and translocation to mitochondria", "G0 and Early G1", "Pre-NOTCH Transcription and Translation", "Pre-NOTCH Transcription and Translation", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Oxidative Stress Induced Senescence", "Oncogene Induced Senescence", "Activation of E2F1 target genes at G1/S", "Activation of E2F1 target genes at G1/S", "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "Cyclin E associated events during G1/S transition ", "Cyclin D associated events in G1", "Cyclin A:Cdk2-associated events at S phase entry", "Transcriptional Regulation by E2F6"], "Q14191": ["SUMOylation of DNA damage response and repair proteins", "HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Regulation of TP53 Activity through Phosphorylation", "G2/M DNA damage checkpoint"], "Q14192": ["PPARA activates gene expression"], "Q14194": ["CRMPs in Sema3A signaling"], "Q14195": ["CRMPs in Sema3A signaling"], "Q14197": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q14203": ["MHC class II antigen presentation", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "XBP1(S) activates chaperone genes", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic"], "Q14203-2": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "Q14204": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Regulation of PLK1 Activity at G2/M Transition", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "RHO GTPases Activate Formins", "Neutrophil degranulation", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "AURKA Activation by TPX2"], "Q14209": ["Oxidative Stress Induced Senescence", "Oncogene Induced Senescence", "CDC6 association with the ORC:origin complex", "Cyclin D associated events in G1"], "Q14210": ["Post-translational modification: synthesis of GPI-anchored proteins"], "Q14213": ["Interleukin-35 Signalling", "Interleukin-27 signaling"], "Q14232": ["Recycling of eIF2:GDP"], "Q14240": ["ISG15 antiviral mechanism", "L13a-mediated translational silencing of Ceruloplasmin expression", "Deadenylation of mRNA", "Translation initiation complex formation", "Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "Q14241": ["Formation of RNA Pol II elongation complex ", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "RNA Polymerase II Transcription Elongation"], "Q14242": ["Cell surface interactions at the vascular wall"], "Q14246": ["Class B/2 (Secretin family receptors)"], "Q14247": ["RHO GTPases activate PAKs", "Clathrin-mediated endocytosis"], "Q14254": ["Synaptic adhesion-like molecules"], "Q14258": ["ISG15 antiviral mechanism", "DDX58/IFIH1-mediated induction of interferon-alpha/beta", "Termination of translesion DNA synthesis", "Ovarian tumor domain proteases", "Interferon gamma signaling", "TRAF3-dependent IRF activation pathway", "TRAF6 mediated IRF7 activation", "TRAF6 mediated NF-kB activation", "TRAF6 mediated NF-kB activation", "NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10", "Negative regulators of DDX58/IFIH1 signaling", "Negative regulators of DDX58/IFIH1 signaling"], "Q14289": ["Signal regulatory protein family interactions", "VEGFA-VEGFR2 Pathway", "Interleukin-2 signaling"], "Q14314": ["Neutrophil degranulation"], "Q14315": ["Cell-extracellular matrix interactions"], "Q14318": ["Ub-specific processing proteases"], "Q14324": ["Striated Muscle Contraction"], "Q14330": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (i) signalling events"], "Q14332": ["TCF dependent signaling in response to WNT", "Class B/2 (Secretin family receptors)", "Ca2+ pathway", "Ca2+ pathway", "Asymmetric localization of PCP proteins", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "WNT5A-dependent internalization of FZD2, FZD5 and ROR2"], "Q14344": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events", "Thromboxane signalling through TP receptor", "Thrombin signalling through proteinase activated receptors (PARs)", "Thrombin signalling through proteinase activated receptors (PARs)"], "Q14353": ["Creatine metabolism", "Transcriptional Regulation by MECP2"], "Q14376": ["Defective GALE can cause Epimerase-deficiency galactosemia (EDG)", "Galactose catabolism"], "Q14393": ["Platelet degranulation ", "Gamma-carboxylation of protein precursors", "Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "Removal of aminoterminal propeptides from gamma-carboxylated proteins", "Cell surface interactions at the vascular wall", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "Q14397": ["Regulation of Glucokinase by Glucokinase Regulatory Protein", "Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)"], "Q14409": ["Triglyceride biosynthesis"], "Q14410": ["Triglyceride biosynthesis"], "Q14416": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "Q14432": ["cGMP effects", "G alpha (s) signalling events"], "Q14435": ["FGFR3c ligand binding and activation", "Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)", "O-linked glycosylation of mucins"], "Q14439": ["G alpha (s) signalling events"], "Q14442": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "Q14449": ["Tie2 Signaling"], "Q14451": ["GRB7 events in ERBB2 signaling", "Signaling by SCF-KIT", "Downstream signal transduction", "Tie2 Signaling", "RET signaling"], "Q14457": ["Macroautophagy", "Ub-specific processing proteases"], "Q14469": ["Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "NOTCH1 Intracellular Domain Regulates Transcription", "NOTCH2 intracellular domain regulates transcription", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "RUNX2 regulates osteoblast differentiation", "RUNX3 regulates NOTCH signaling", "RUNX3 regulates NOTCH signaling", "NOTCH3 Intracellular Domain Regulates Transcription", "NOTCH4 Intracellular Domain Regulates Transcription"], "Q14493": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of the SLBP Dependant Mature mRNA", "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"], "Q14500": ["Activation of G protein gated Potassium channels", "Classical Kir channels", "Phase 4 - resting membrane potential", "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "Q14512": ["FGFR2b ligand binding and activation"], "Q14515": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "Q14524": ["Interaction between L1 and Ankyrins", "Phase 0 - rapid depolarisation"], "Q14525": ["Keratinization", "Formation of the cornified envelope"], "Q14526": ["SUMOylation of transcription factors"], "Q14527": ["E3 ubiquitin ligases ubiquitinate target proteins"], "Q14532": ["Keratinization", "Formation of the cornified envelope"], "Q14533": ["Keratinization", "Formation of the cornified envelope"], "Q14534": ["Cholesterol biosynthesis", "Activation of gene expression by SREBF (SREBP)"], "Q14541": ["Regulation of gene expression in beta cells", "Nuclear Receptor transcription pathway"], "Q14542": ["Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"], "Q14554": ["XBP1(S) activates chaperone genes"], "Q14563": ["Sema3A PAK dependent Axon repulsion", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "CRMPs in Sema3A signaling", "CRMPs in Sema3A signaling"], "Q14565": ["Meiotic recombination"], "Q14566": ["Activation of ATR in response to replication stress", "Unwinding of DNA", "Assembly of the pre-replicative complex", "Orc1 removal from chromatin", "Activation of the pre-replicative complex", "Switching of origins to a post-replicative state"], "Q14571": ["PLC beta mediated events", "Effects of PIP2 hydrolysis", "Elevation of cytosolic Ca2+ levels", "DAG and IP3 signaling", "Role of phospholipids in phagocytosis", "FCERI mediated Ca+2 mobilization", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Ca2+ pathway", "Regulation of insulin secretion", "VEGFR2 mediated cell proliferation", "Ion homeostasis", "Ion homeostasis", "CLEC7A (Dectin-1) induces NFAT activation", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "Q14573": ["PLC beta mediated events", "Effects of PIP2 hydrolysis", "Elevation of cytosolic Ca2+ levels", "DAG and IP3 signaling", "Role of phospholipids in phagocytosis", "FCERI mediated Ca+2 mobilization", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Ca2+ pathway", "Regulation of insulin secretion", "VEGFR2 mediated cell proliferation", "Ion homeostasis", "Ion homeostasis", "CLEC7A (Dectin-1) induces NFAT activation", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "Q14574": ["Keratinization", "Formation of the cornified envelope"], "Q14584": ["Generic Transcription Pathway"], "Q14586": ["Generic Transcription Pathway"], "Q14587": ["Generic Transcription Pathway"], "Q14588": ["Generic Transcription Pathway"], "Q14590": ["Generic Transcription Pathway"], "Q14592": ["Generic Transcription Pathway"], "Q14593": ["Generic Transcription Pathway"], "Q14623": ["Class B/2 (Secretin family receptors)", "Hedgehog ligand biogenesis", "Release of Hh-Np from the secreting cell", "Release of Hh-Np from the secreting cell", "Ligand-receptor interactions", "Ligand-receptor interactions", "Hedgehog 'on' state", "Activation of SMO", "HHAT G278V abrogates palmitoylation of Hh-Np", "RUNX2 regulates chondrocyte maturation"], "Q14624": ["Platelet degranulation "], "Q14626": ["IL-6-type cytokine receptor ligand interactions"], "Q14627": ["Interleukin-4 and Interleukin-13 signaling"], "Q14642": ["Synthesis of IP2, IP, and Ins in the cytosol"], "Q14643": ["PLC beta mediated events", "Effects of PIP2 hydrolysis", "Elevation of cytosolic Ca2+ levels", "DAG and IP3 signaling", "Role of phospholipids in phagocytosis", "FCERI mediated Ca+2 mobilization", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Ca2+ pathway", "cGMP effects", "Regulation of insulin secretion", "VEGFR2 mediated cell proliferation", "Ion homeostasis", "Ion homeostasis", "CLEC7A (Dectin-1) induces NFAT activation", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "Q14644": ["Regulation of RAS by GAPs", "Signaling by RAS mutants"], "Q14653": ["ISG15 antiviral mechanism", "IRF3 mediated activation of type 1 IFN", "IRF3 mediated activation of type 1 IFN", "LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "Regulation of innate immune responses to cytosolic DNA", "IRF3-mediated induction of type I IFN", "Interferon gamma signaling", "TICAM1-dependent activation of IRF3/IRF7", "Interferon alpha/beta signaling", "TRAF3-dependent IRF activation pathway", "TRAF6 mediated IRF7 activation", "Negative regulators of DDX58/IFIH1 signaling", "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon"], "Q14654": ["ATP sensitive Potassium channels", "ABC-family proteins mediated transport", "Regulation of insulin secretion", "Ion homeostasis", "Defective ABCC8 can cause hypoglycemias and hyperglycemias"], "Q14657": ["tRNA modification in the nucleus and cytosol"], "Q14669": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q14671": ["Golgi Associated Vesicle Biogenesis"], "Q14674": ["Separation of Sister Chromatids"], "Q14676": ["SUMOylation of DNA damage response and repair proteins", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "TP53 Regulates Transcription of DNA Repair Genes", "G2/M DNA damage checkpoint"], "Q14677": ["Golgi Associated Vesicle Biogenesis"], "Q14678": ["Estrogen-dependent gene expression"], "Q14679": ["Carboxyterminal post-translational modifications of tubulin"], "Q14683": ["Meiotic synapsis", "Separation of Sister Chromatids", "Establishment of Sister Chromatid Cohesion", "Cohesin Loading onto Chromatin", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA damage response and repair proteins", "Estrogen-dependent gene expression"], "Q14686": ["RORA activates gene expression", "BMAL1:CLOCK,NPAS2 activates circadian gene expression", "PPARA activates gene expression", "PPARA activates gene expression", "Transcriptional activation of mitochondrial biogenesis", "Activation of gene expression by SREBF (SREBP)", "Transcriptional regulation of white adipocyte differentiation", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)", "Circadian Clock", "Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "Q14690": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "Q14691": ["Unwinding of DNA", "Unwinding of DNA"], "Q14692": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "Q14693": ["Synthesis of PC", "Synthesis of PE", "Depolymerisation of the Nuclear Lamina", "Triglyceride biosynthesis"], "Q14694": ["Termination of translesion DNA synthesis", "Ub-specific processing proteases"], "Q14697": ["N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "Calnexin/calreticulin cycle"], "Q14703": ["Regulation of cholesterol biosynthesis by SREBP (SREBF)", "ATF6 (ATF6-alpha) activates chaperones", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "CREB3 factors activate genes", "CREB3 factors activate genes", "Post-translational protein phosphorylation", "Assembly of active LPL and LIPC lipase complexes"], "Q14721": ["Voltage gated Potassium channels", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion"], "Q14722": ["Voltage gated Potassium channels"], "Q14738": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Integration of energy metabolism", "PP2A-mediated dephosphorylation of key metabolic factors", "DARPP-32 events", "Degradation of beta-catenin by the destruction complex", "Beta-catenin phosphorylation cascade", "ERK/MAPK targets", "ERKs are inactivated", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "CTLA4 inhibitory signaling", "Platelet sensitization by LDL", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Misspliced GSK3beta mutants stabilize beta-catenin", "S33 mutants of beta-catenin aren't phosphorylated", "S37 mutants of beta-catenin aren't phosphorylated", "S45 mutants of beta-catenin aren't phosphorylated", "T41 mutants of beta-catenin aren't phosphorylated", "APC truncation mutants have impaired AXIN binding", "AXIN missense mutants destabilize the destruction complex", "Truncations of AMER1 destabilize the destruction complex", "RHO GTPases Activate Formins", "RAF activation", "Negative regulation of MAPK pathway", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Mitotic Prometaphase", "Glycolysis"], "Q14739": ["Cholesterol biosynthesis", "Regulation of MECP2 expression and activity"], "Q14746": ["COPI-mediated anterograde transport", "Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network"], "Q14749": ["Metabolism of ingested SeMet, Sec, MeSec into H2Se", "Glyoxylate metabolism and glycine degradation"], "Q14764": ["Neutrophil degranulation"], "Q14765": ["Interleukin-20 family signaling", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "Interleukin-35 Signalling", "Interleukin-12 signaling", "Interleukin-12 signaling", "Interleukin-23 signaling", "Interleukin-21 signaling"], "Q14766": ["Molecules associated with elastic fibres", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "Q14767": ["Molecules associated with elastic fibres"], "Q14773": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Integrin cell surface interactions"], "Q14781": ["Oxidative Stress Induced Senescence", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of transcription cofactors", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA methylation proteins", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription"], "Q14789": ["Golgi Associated Vesicle Biogenesis", "COPI-mediated anterograde transport"], "Q14790": ["Apoptotic cleavage of cellular proteins", "Caspase activation via Death Receptors in the presence of ligand", "NOD1/2 Signaling Pathway", "TRIF-mediated programmed cell death", "Caspase-mediated cleavage of cytoskeletal proteins", "Regulation by c-FLIP", "RIPK1-mediated regulated necrosis", "CASP8 activity is inhibited", "TNFR1-induced proapoptotic signaling", "Regulation of TNFR1 signaling", "CLEC7A/inflammasome pathway", "Regulation of necroptotic cell death", "Dimerization of procaspase-8", "Activation, myristolyation of BID and translocation to mitochondria", "Apoptotic execution phase", "FasL/ CD95L signaling", "TRAIL signaling", "TLR3-mediated TICAM1-dependent programmed cell death", "NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10"], "Q147X3": ["Retrograde transport at the Trans-Golgi-Network"], "Q14802": ["Ion homeostasis", "Ion transport by P-type ATPases"], "Q14807": ["MHC class II antigen presentation", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "Q14814": ["Transcriptional activation of mitochondrial biogenesis", "CDO in myogenesis", "Circadian Clock"], "Q14831": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "Q14832": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "Q14833": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "Q14839": ["HDACs deacetylate histones", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "Regulation of TP53 Activity through Acetylation", "RNA Polymerase I Transcription Initiation", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription"], "Q14849": ["Pregnenolone biosynthesis"], "Q14865": ["HDMs demethylate histones"], "Q14872": ["PPARA activates gene expression", "Activation of gene expression by SREBF (SREBP)", "MTF1 activates gene expression", "MTF1 activates gene expression"], "Q14894": ["Lysine catabolism"], "Q14896": ["Striated Muscle Contraction"], "Q14914": ["Synthesis of Leukotrienes (LT) and Eoxins (EX)", "Synthesis of Lipoxins (LX)"], "Q14916": ["Organic anion transporters"], "Q14919": ["Signaling by NODAL", "Signaling by Activin"], "Q14929": ["Generic Transcription Pathway"], "Q14938": ["RNA Polymerase III Transcription Termination", "RNA Polymerase III Abortive And Retractive Initiation"], "Q14940": ["Sodium/Proton exchangers"], "Q14943": ["DAP12 interactions"], "Q14953": ["DAP12 interactions"], "Q14954": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "DAP12 interactions"], "Q14956": ["PTK6 promotes HIF1A stabilization"], "Q14957": ["Unblocking of NMDA receptors, glutamate binding and activation", "Unblocking of NMDA receptors, glutamate binding and activation", "Neurexins and neuroligins", "Synaptic adhesion-like molecules", "Negative regulation of NMDA receptor-mediated neuronal transmission", "Long-term potentiation"], "Q14964": ["Intra-Golgi traffic", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "Q14966": ["Transcriptional regulation of white adipocyte differentiation"], "Q14973": ["Recycling of bile acids and salts"], "Q14974": ["ISG15 antiviral mechanism", "Regulation of cholesterol biosynthesis by SREBP (SREBF)", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Nuclear import of Rev protein", "Nuclear import of Rev protein", "Activation of DNA fragmentation factor", "Neutrophil degranulation"], "Q14980": ["Recruitment of NuMA to mitotic centrosomes", "Mitotic Prophase"], "Q14982": ["Post-translational modification: synthesis of GPI-anchored proteins"], "Q14993": ["Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Collagen chain trimerization"], "Q14994-1": ["Nuclear Receptor transcription pathway"], "Q14994-2": ["Nuclear Receptor transcription pathway"], "Q14995": ["Nuclear Receptor transcription pathway"], "Q14997": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q14999": ["XBP1(S) activates chaperone genes", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q149N8": ["E3 ubiquitin ligases ubiquitinate target proteins"], "Q14C86": ["Clathrin-mediated endocytosis", "RAB GEFs exchange GTP for GDP on RABs"], "Q14CB8": ["Rho GTPase cycle"], "Q14CN2": ["Stimuli-sensing channels"], "Q14CN4": ["Keratinization", "Formation of the cornified envelope"], "Q14CW9": ["HATs acetylate histones"], "Q14D33": ["Olfactory Signaling Pathway"], "Q15003": ["Condensation of Prometaphase Chromosomes", "Condensation of Prometaphase Chromosomes"], "Q15004": ["Termination of translesion DNA synthesis"], "Q15005": ["SRP-dependent cotranslational protein targeting to membrane", "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)", "Synthesis, secretion, and deacylation of Ghrelin"], "Q15007": ["Processing of Capped Intron-Containing Pre-mRNA"], "Q15008": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "Neutrophil degranulation", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q15011": ["ATF4 activates genes"], "Q15014": ["HATs acetylate histones"], "Q15018": ["Metalloprotease DUBs"], "Q15019": ["Anchoring of the basal body to the plasma membrane"], "Q15021": ["Condensation of Prometaphase Chromosomes", "Condensation of Prometaphase Chromosomes"], "Q15022": ["PRC2 methylates histones and DNA", "Oxidative Stress Induced Senescence", "PKMTs methylate histone lysines", "SUMOylation of chromatin organization proteins", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription", "Transcriptional Regulation by E2F6"], "Q15024": ["ATF4 activates genes", "mRNA decay by 3' to 5' exoribonuclease", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "KSRP (KHSRP) binds and destabilizes mRNA", "Major pathway of rRNA processing in the nucleolus and cytosol"], "Q15025": ["Ovarian tumor domain proteases"], "Q15029": ["mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "Q15031": ["Mitochondrial tRNA aminoacylation"], "Q15034": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q15040": ["Josephin domain DUBs"], "Q15042": ["COPI-independent Golgi-to-ER retrograde traffic", "RAB GEFs exchange GTP for GDP on RABs"], "Q15043": ["Zinc influx into cells by the SLC39 gene family"], "Q15046": ["SeMet incorporation into proteins", "Cytosolic tRNA aminoacylation", "Mitochondrial tRNA aminoacylation"], "Q15047": ["PKMTs methylate histone lysines"], "Q15051": ["Anchoring of the basal body to the plasma membrane"], "Q15052": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events", "Regulation of cytoskeletal remodeling and cell spreading by IPP complex components", "G beta:gamma signalling through CDC42"], "Q15054": ["Recognition of DNA damage by PCNA-containing replication complex", "Polymerase switching on the C-strand of the telomere", "Processive synthesis on the C-strand of the telomere", "Telomere C-strand (Lagging Strand) Synthesis", "Removal of the Flap Intermediate from the C-strand", "Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "PCNA-Dependent Long Patch Base Excision Repair", "Termination of translesion DNA synthesis", "HDR through Homologous Recombination (HRR)", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Polymerase switching", "Removal of the Flap Intermediate", "Processive synthesis on the lagging strand"], "Q15056": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "Q15058": ["RHO GTPases activate CIT"], "Q15061": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "Q15067": ["Peroxisomal protein import", "Peroxisomal protein import", "TYSND1 cleaves peroxisomal proteins"], "Q15067-1": ["PPARA activates gene expression"], "Q15067-2": ["alpha-linolenic acid (ALA) metabolism", "Beta-oxidation of very long chain fatty acids"], "Q15070": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q15075": ["Toll Like Receptor 9 (TLR9) Cascade"], "Q15077": ["G alpha (q) signalling events", "P2Y receptors"], "Q15078": ["CRMPs in Sema3A signaling", "CRMPs in Sema3A signaling", "Regulation of TP53 Activity through Phosphorylation", "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "Activated NTRK2 signals through CDK5"], "Q15080": ["ROS, RNS production in phagocytes", "Cross-presentation of particulate exogenous antigens (phagosomes)", "Detoxification of Reactive Oxygen Species", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate NADPH Oxidases"], "Q15084": ["XBP1(S) activates chaperone genes", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "Q15102": ["COPI-independent Golgi-to-ER retrograde traffic"], "Q15109": ["TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "Advanced glycosylation endproduct receptor signaling", "Advanced glycosylation endproduct receptor signaling", "TRAF6 mediated NF-kB activation"], "Q15113": ["Collagen biosynthesis and modifying enzymes", "Crosslinking of collagen fibrils"], "Q15116": ["PD-1 signaling"], "Q15118": ["Regulation of pyruvate dehydrogenase (PDH) complex", "Signaling by Retinoic Acid"], "Q15119": ["Regulation of pyruvate dehydrogenase (PDH) complex", "Signaling by Retinoic Acid"], "Q15120": ["Regulation of pyruvate dehydrogenase (PDH) complex", "Signaling by Retinoic Acid"], "Q15121": ["RAF-independent MAPK1/3 activation", "RAF/MAP kinase cascade"], "Q15125": ["Cholesterol biosynthesis via desmosterol", "Cholesterol biosynthesis via lathosterol"], "Q15126": ["Cholesterol biosynthesis", "Activation of gene expression by SREBF (SREBP)"], "Q15139": ["Sphingolipid de novo biosynthesis"], "Q15147": ["PLC beta mediated events", "PLC beta mediated events", "Synthesis of IP3 and IP4 in the cytosol", "G alpha (q) signalling events", "G alpha (q) signalling events"], "Q15149": ["Assembly of collagen fibrils and other multimeric structures", "Caspase-mediated cleavage of cytoskeletal proteins", "Type I hemidesmosome assembly"], "Q15154": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "Q15165": ["Synthesis of 5-eicosatetraenoic acids"], "Q15166": ["Synthesis of 5-eicosatetraenoic acids"], "Q15172": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Degradation of beta-catenin by the destruction complex", "Beta-catenin phosphorylation cascade", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "CTLA4 inhibitory signaling", "Platelet sensitization by LDL", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Misspliced GSK3beta mutants stabilize beta-catenin", "S33 mutants of beta-catenin aren't phosphorylated", "S37 mutants of beta-catenin aren't phosphorylated", "S45 mutants of beta-catenin aren't phosphorylated", "T41 mutants of beta-catenin aren't phosphorylated", "APC truncation mutants have impaired AXIN binding", "AXIN missense mutants destabilize the destruction complex", "Truncations of AMER1 destabilize the destruction complex", "RHO GTPases Activate Formins", "RAF activation", "Negative regulation of MAPK pathway", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Mitotic Prometaphase"], "Q15173": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Degradation of beta-catenin by the destruction complex", "Beta-catenin phosphorylation cascade", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "XBP1(S) activates chaperone genes", "CTLA4 inhibitory signaling", "Platelet sensitization by LDL", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Misspliced GSK3beta mutants stabilize beta-catenin", "S33 mutants of beta-catenin aren't phosphorylated", "S37 mutants of beta-catenin aren't phosphorylated", "S45 mutants of beta-catenin aren't phosphorylated", "T41 mutants of beta-catenin aren't phosphorylated", "APC truncation mutants have impaired AXIN binding", "AXIN missense mutants destabilize the destruction complex", "Truncations of AMER1 destabilize the destruction complex", "RHO GTPases Activate Formins", "RAF activation", "Negative regulation of MAPK pathway", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Mitotic Prometaphase"], "Q15181": ["Cytosolic tRNA aminoacylation", "Pyrophosphate hydrolysis"], "Q15185": ["Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "HSF1 activation", "Attenuation phase", "Aryl hydrocarbon receptor signalling", "ESR-mediated signaling", "Estrogen-dependent gene expression"], "Q15223": ["Adherens junctions interactions", "Nectin/Necl trans heterodimerization"], "Q15238": ["Cell surface interactions at the vascular wall"], "Q15262": ["EGFR downregulation"], "Q15269": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "Q15274": ["Nicotinate metabolism"], "Q15276": ["TBC/RABGAPs"], "Q15283": ["Regulation of RAS by GAPs", "Signaling by RAS mutants"], "Q15286": ["TBC/RABGAPs", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "Q15287": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "Q15291": ["Formation of the beta-catenin:TCF transactivating complex", "PKMTs methylate histone lysines", "Deactivation of the beta-catenin transactivating complex", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Neddylation"], "Q15293": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "Q15303-1": ["Signaling by ERBB2", "Signaling by ERBB4", "SHC1 events in ERBB2 signaling", "SHC1 events in ERBB2 signaling", "PI3K events in ERBB4 signaling", "SHC1 events in ERBB4 signaling", "Nuclear signaling by ERBB4", "Nuclear signaling by ERBB4", "Downregulation of ERBB4 signaling", "PIP3 activates AKT signaling", "GRB2 events in ERBB2 signaling", "PI3K events in ERBB2 signaling", "Constitutive Signaling by Aberrant PI3K in Cancer", "RAF/MAP kinase cascade", "ERBB2 Regulates Cell Motility", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "ERBB2 Activates PTK6 Signaling", "Downregulation of ERBB2 signaling", "Estrogen-dependent gene expression", "Long-term potentiation"], "Q15303-2": ["Signaling by ERBB2", "Signaling by ERBB4", "SHC1 events in ERBB2 signaling", "SHC1 events in ERBB2 signaling", "PI3K events in ERBB4 signaling", "SHC1 events in ERBB4 signaling", "Downregulation of ERBB4 signaling", "PIP3 activates AKT signaling", "GRB2 events in ERBB2 signaling", "PI3K events in ERBB2 signaling", "Constitutive Signaling by Aberrant PI3K in Cancer", "RAF/MAP kinase cascade", "ERBB2 Regulates Cell Motility", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "ERBB2 Activates PTK6 Signaling", "Downregulation of ERBB2 signaling", "Long-term potentiation"], "Q15303-3": ["Signaling by ERBB2", "Signaling by ERBB4", "SHC1 events in ERBB2 signaling", "SHC1 events in ERBB2 signaling", "SHC1 events in ERBB4 signaling", "Nuclear signaling by ERBB4", "Nuclear signaling by ERBB4", "Downregulation of ERBB4 signaling", "GRB2 events in ERBB2 signaling", "RAF/MAP kinase cascade", "ERBB2 Regulates Cell Motility", "ERBB2 Activates PTK6 Signaling", "Downregulation of ERBB2 signaling", "Estrogen-dependent gene expression", "Long-term potentiation"], "Q15306": ["Interleukin-4 and Interleukin-13 signaling", "Interferon gamma signaling", "Interferon alpha/beta signaling"], "Q15311": ["Rho GTPase cycle"], "Q15323": ["Keratinization", "Formation of the cornified envelope"], "Q15327": ["PPARA activates gene expression"], "Q15329": ["Transcription of E2F targets under negative control by DREAM complex", "Transcription of E2F targets under negative control by DREAM complex", "Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1", "G0 and Early G1", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Activation of E2F1 target genes at G1/S", "Activation of E2F1 target genes at G1/S", "Cyclin E associated events during G1/S transition ", "Cyclin D associated events in G1", "Cyclin A:Cdk2-associated events at S phase entry"], "Q15345": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q15349": ["ERK/MAPK targets", "CREB phosphorylation", "Senescence-Associated Secretory Phenotype (SASP)", "Senescence-Associated Secretory Phenotype (SASP)", "Recycling pathway of L1", "CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling", "RSK activation", "RSK activation", "Gastrin-CREB signalling pathway via PKC and MAPK"], "Q15361": ["ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "Surfactant metabolism", "Defective pro-SFTPB causes pulmonary surfactant metabolism dysfunction 1 (SMDP1) and respiratory distress syndrome (RDS)", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Transcription Termination", "RNA Polymerase I Transcription Termination"], "Q15363": ["Pre-NOTCH Processing in Golgi", "COPII-mediated vesicle transport", "Cargo concentration in the ER", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "Q15365": ["mRNA Splicing - Major Pathway", "Processing of Capped Intron-Containing Pre-mRNA"], "Q15366": ["mRNA Splicing - Major Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "Negative regulators of DDX58/IFIH1 signaling"], "Q15369": ["Formation of RNA Pol II elongation complex ", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "Vif-mediated degradation of APOBEC3G", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "RNA Polymerase II Transcription Elongation", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q15370": ["Formation of RNA Pol II elongation complex ", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "Vif-mediated degradation of APOBEC3G", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "RNA Polymerase II Transcription Elongation", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q15375": ["EPH-Ephrin signaling", "EPH-Ephrin signaling", "EPHA-mediated growth cone collapse", "EPHA-mediated growth cone collapse", "EPH-ephrin mediated repulsion of cells", "EPH-ephrin mediated repulsion of cells"], "Q15382": ["Macroautophagy", "mTOR signalling", "mTORC1-mediated signalling", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Regulation of PTEN gene transcription"], "Q15386": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q15388": ["Mitochondrial protein import", "Pink/Parkin Mediated Mitophagy", "Ub-specific processing proteases"], "Q15389": ["Tie2 Signaling", "Tie2 Signaling", "RAF/MAP kinase cascade"], "Q15391": ["P2Y receptors", "G alpha (i) signalling events"], "Q15392": ["Cholesterol biosynthesis via desmosterol", "Cholesterol biosynthesis via lathosterol"], "Q15393": ["mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "Q15398": ["NOTCH3 Intracellular Domain Regulates Transcription"], "Q15399": ["ER-Phagosome pathway", "Beta defensins", "MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "Toll Like Receptor TLR1:TLR2 Cascade", "MyD88 deficiency (TLR2/4)", "IRAK4 deficiency (TLR2/4)", "Regulation of TLR by endogenous ligand"], "Q15404": ["Regulation of cytoskeletal remodeling and cell spreading by IPP complex components"], "Q15406-1": ["POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation", "Nuclear Receptor transcription pathway"], "Q15406-2": ["Nuclear Receptor transcription pathway"], "Q15406-3": ["Nuclear Receptor transcription pathway"], "Q15406-4": ["Nuclear Receptor transcription pathway"], "Q15406-5": ["Nuclear Receptor transcription pathway"], "Q15413": ["Stimuli-sensing channels", "Ion homeostasis"], "Q15418": ["ERK/MAPK targets", "CREB phosphorylation", "Senescence-Associated Secretory Phenotype (SASP)", "Senescence-Associated Secretory Phenotype (SASP)", "Recycling pathway of L1", "CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling", "RSK activation", "RSK activation", "Gastrin-CREB signalling pathway via PKC and MAPK"], "Q15424": ["SUMOylation of transcription cofactors"], "Q15427": ["mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "Q15428": ["mRNA Splicing - Major Pathway"], "Q15431": ["Meiotic synapsis"], "Q15436": ["Regulation of cholesterol biosynthesis by SREBP (SREBF)", "COPII-mediated vesicle transport", "MHC class II antigen presentation", "Cargo concentration in the ER", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "Q15438": ["Intra-Golgi traffic"], "Q15459": ["mRNA Splicing - Major Pathway"], "Q15464": ["VEGFA-VEGFR2 Pathway", "VEGFA-VEGFR2 Pathway"], "Q15465": ["Class B/2 (Secretin family receptors)", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Release of Hh-Np from the secreting cell", "Release of Hh-Np from the secreting cell", "Ligand-receptor interactions", "Ligand-receptor interactions", "Hedgehog 'on' state", "Activation of SMO", "HHAT G278V abrogates palmitoylation of Hh-Np"], "Q15466": ["Nuclear Receptor transcription pathway"], "Q15477": ["Association of TriC/CCT with target proteins during biosynthesis", "mRNA decay by 3' to 5' exoribonuclease"], "Q15485": ["Lectin pathway of complement activation", "Initial triggering of complement", "Ficolins bind to repetitive carbohydrate structures on the target cell surface"], "Q15517": ["Formation of the cornified envelope"], "Q15526": ["TP53 Regulates Metabolic Genes", "Respiratory electron transport"], "Q15528": ["PPARA activates gene expression", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "Q15542": ["HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "Q15543": ["HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "Q15544": ["HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "Q15545": ["HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "Q15554": ["Meiotic synapsis", "Packaging Of Telomere Ends", "DNA Damage/Telomere Stress Induced Senescence"], "Q15561": ["YAP1- and WWTR1 (TAZ)-stimulated gene expression", "RUNX3 regulates YAP1-mediated transcription"], "Q15562": ["YAP1- and WWTR1 (TAZ)-stimulated gene expression", "RUNX3 regulates YAP1-mediated transcription"], "Q15569": ["Regulation of cytoskeletal remodeling and cell spreading by IPP complex components"], "Q15572": ["SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase I Transcription Termination"], "Q15573": ["SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase I Transcription Termination"], "Q15582": ["Amyloid fiber formation"], "Q15583": ["Downregulation of SMAD2/3:SMAD4 transcriptional activity", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription"], "Q15596": ["RORA activates gene expression", "BMAL1:CLOCK,NPAS2 activates circadian gene expression", "Recycling of bile acids and salts", "Synthesis of bile acids and bile salts", "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "PPARA activates gene expression", "PPARA activates gene expression", "Endogenous sterols", "Transcriptional activation of mitochondrial biogenesis", "Activation of gene expression by SREBF (SREBP)", "HATs acetylate histones", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation", "SUMOylation of transcription cofactors", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)", "Circadian Clock", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Estrogen-dependent gene expression"], "Q15612": ["Olfactory Signaling Pathway"], "Q15615": ["Olfactory Signaling Pathway"], "Q15617": ["Olfactory Signaling Pathway"], "Q15619": ["Olfactory Signaling Pathway"], "Q15620": ["Olfactory Signaling Pathway"], "Q15622": ["Olfactory Signaling Pathway"], "Q15628": ["Caspase activation via Death Receptors in the presence of ligand", "Regulation by c-FLIP", "RIPK1-mediated regulated necrosis", "CASP8 activity is inhibited", "TNFR1-induced proapoptotic signaling", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "Regulation of necroptotic cell death", "Dimerization of procaspase-8", "TNF signaling"], "Q15629": ["SRP-dependent cotranslational protein targeting to membrane"], "Q15631": ["Small interfering RNA (siRNA) biogenesis"], "Q15633": ["MicroRNA (miRNA) biogenesis", "Small interfering RNA (siRNA) biogenesis"], "Q15637": ["mRNA Splicing - Major Pathway"], "Q15642": ["Rho GTPase cycle", "Clathrin-mediated endocytosis"], "Q15643": ["Intraflagellar transport", "Intra-Golgi traffic"], "Q15646": ["Interferon gamma signaling", "OAS antiviral response", "Interferon alpha/beta signaling"], "Q15648": ["RORA activates gene expression", "BMAL1:CLOCK,NPAS2 activates circadian gene expression", "PPARA activates gene expression", "PPARA activates gene expression", "Generic Transcription Pathway", "Transcriptional activation of mitochondrial biogenesis", "Activation of gene expression by SREBF (SREBP)", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation", "Nuclear Receptor transcription pathway", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)", "Circadian Clock", "Estrogen-dependent gene expression"], "Q15652": ["Factors involved in megakaryocyte development and platelet production"], "Q15653": ["Activation of NF-kappaB in B cells", "RIP-mediated NFkB activation via ZBP1", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "TRAF6 mediated NF-kB activation"], "Q15661": ["Activation of Matrix Metalloproteinases"], "Q15669": ["Rho GTPase cycle"], "Q15672": ["Interleukin-4 and Interleukin-13 signaling", "Transcriptional regulation by RUNX2", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity"], "Q15678": ["Interleukin-37 signaling"], "Q15691": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "RHO GTPases Activate Formins", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "AURKA Activation by TPX2"], "Q15696": ["mRNA Splicing - Minor Pathway"], "Q15700": ["Unblocking of NMDA receptors, glutamate binding and activation", "Unblocking of NMDA receptors, glutamate binding and activation", "Ras activation upon Ca2+ influx through NMDA receptor", "RAF/MAP kinase cascade", "Neurexins and neuroligins", "Neurexins and neuroligins", "Negative regulation of NMDA receptor-mediated neuronal transmission", "Long-term potentiation"], "Q15717": ["HuR (ELAVL1) binds and stabilizes mRNA", "mRNA Splicing - Major Pathway"], "Q15722": ["Leukotriene receptors", "G alpha (q) signalling events"], "Q15723": ["RUNX1 regulates transcription of genes involved in BCR signaling"], "Q15726": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "Q15735": ["Synthesis of PIPs at the plasma membrane", "Synthesis of IP2, IP, and Ins in the cytosol", "Synthesis of IP3 and IP4 in the cytosol"], "Q15738": ["Cholesterol biosynthesis"], "Q15743": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (q) signalling events"], "Q15746": ["Smooth Muscle Contraction", "RHO GTPases activate PAKs", "RHO GTPases activate PAKs"], "Q15750": ["NOD1/2 Signaling Pathway", "FCERI mediated NF-kB activation", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "activated TAK1 mediates p38 MAPK activation", "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "TNFR1-induced NFkappaB signaling pathway", "CLEC7A (Dectin-1) signaling", "Ub-specific processing proteases", "TICAM1,TRAF6-dependent induction of TAK1 complex", "Interleukin-1 signaling", "IRAK2 mediated activation of TAK1 complex", "TRAF6-mediated induction of TAK1 complex within TLR4 complex", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"], "Q15751": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q15758": ["Amino acid transport across the plasma membrane"], "Q15759": ["NOD1/2 Signaling Pathway", "p38MAPK events", "p38MAPK events", "ERK/MAPK targets", "Activation of PPARGC1A (PGC-1alpha) by phosphorylation", "Oxidative Stress Induced Senescence", "CDO in myogenesis", "CDO in myogenesis", "DSCAM interactions", "VEGFA-VEGFR2 Pathway", "activated TAK1 mediates p38 MAPK activation", "Activation of the AP-1 family of transcription factors", "KSRP (KHSRP) binds and destabilizes mRNA", "RHO GTPases Activate NADPH Oxidases", "Regulation of TP53 Activity through Phosphorylation"], "Q15761": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "Q15762": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "Q15768": ["EPH-Ephrin signaling", "EPH-Ephrin signaling", "EPHB-mediated forward signaling", "EPHB-mediated forward signaling", "Ephrin signaling", "Ephrin signaling", "EPH-ephrin mediated repulsion of cells"], "Q15771": ["Intra-Golgi traffic", "RAB geranylgeranylation"], "Q15776": ["Generic Transcription Pathway"], "Q15788": ["RORA activates gene expression", "BMAL1:CLOCK,NPAS2 activates circadian gene expression", "Recycling of bile acids and salts", "Synthesis of bile acids and bile salts", "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "PPARA activates gene expression", "PPARA activates gene expression", "Endogenous sterols", "Transcriptional activation of mitochondrial biogenesis", "Activation of gene expression by SREBF (SREBP)", "HATs acetylate histones", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation", "SUMOylation of transcription cofactors", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)", "Circadian Clock", "Estrogen-dependent gene expression"], "Q15796": ["Signaling by NODAL", "Signaling by NODAL", "Signaling by Activin", "Downregulation of TGF-beta receptor signaling", "TGF-beta receptor signaling activates SMADs", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "SMAD2/3 Phosphorylation Motif Mutants in Cancer", "SMAD4 MH2 Domain Mutants in Cancer", "SMAD2/3 MH2 Domain Mutants in Cancer", "TGFBR1 KD Mutants in Cancer", "Transcriptional regulation of pluripotent stem cells", "Ub-specific processing proteases", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "FOXO-mediated transcription of cell cycle genes", "FOXO-mediated transcription of cell cycle genes"], "Q15797": ["Signaling by BMP", "Ub-specific processing proteases", "RUNX2 regulates bone development"], "Q15800": ["Cholesterol biosynthesis"], "Q15811": ["NRAGE signals death through JNK", "Rho GTPase cycle", "EPHB-mediated forward signaling", "EPHB-mediated forward signaling", "G alpha (12/13) signalling events", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "Q15813": ["Post-chaperonin tubulin folding pathway"], "Q15814": ["Post-chaperonin tubulin folding pathway"], "Q15819": ["Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "Formation of Incision Complex in GG-NER", "G2/M DNA damage checkpoint", "E3 ubiquitin ligases ubiquitinate target proteins", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q15822": ["Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "Highly calcium permeable nicotinic acetylcholine receptors"], "Q15825": ["Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "Highly calcium permeable nicotinic acetylcholine receptors"], "Q15831": ["AMPK inhibits chREBP transcriptional activation activity", "Energy dependent regulation of mTOR by LKB1-AMPK", "Regulation of TP53 Activity through Phosphorylation", "FOXO-mediated transcription of cell death genes"], "Q15833": ["Platelet degranulation ", "Other interleukin signaling"], "Q15835": ["Inactivation, recovery and regulation of the phototransduction cascade", "Inactivation, recovery and regulation of the phototransduction cascade"], "Q15836": ["ER-Phagosome pathway", "Retrograde transport at the Trans-Golgi-Network", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "Q15842": ["ATP sensitive Potassium channels"], "Q15843": ["TGF-beta receptor signaling activates SMADs", "UCH proteinases", "Cargo recognition for clathrin-mediated endocytosis", "Neddylation", "Iron uptake and transport"], "Q15847": ["Transcriptional regulation of white adipocyte differentiation"], "Q15848": ["AMPK inhibits chREBP transcriptional activation activity", "AMPK inhibits chREBP transcriptional activation activity", "Transcriptional regulation of white adipocyte differentiation"], "Q15849": ["Transport of bile salts and organic acids, metal ions and amine compounds"], "Q15853": ["Estrogen-dependent gene expression"], "Q15858": ["Interaction between L1 and Ankyrins", "Phase 0 - rapid depolarisation"], "Q15878": ["Presynaptic depolarization and calcium channel opening", "Regulation of insulin secretion"], "Q15904": ["Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "Q15906": ["HATs acetylate histones"], "Q15907": ["TBC/RABGAPs", "RAB geranylgeranylation"], "Q15910": ["PRC2 methylates histones and DNA", "Oxidative Stress Induced Senescence", "PKMTs methylate histone lysines", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription", "Transcriptional Regulation by E2F6"], "Q15911": ["RUNX3 regulates CDKN1A transcription"], "Q15928": ["Generic Transcription Pathway"], "Q15935": ["Generic Transcription Pathway"], "Q15937": ["Generic Transcription Pathway"], "Q15940": ["Generic Transcription Pathway"], "Q15973": ["Generic Transcription Pathway"], "Q16099": ["Activation of Ca-permeable Kainate Receptor"], "Q16134": ["Respiratory electron transport"], "Q16143": ["MTF1 activates gene expression"], "Q16181": ["MAPK6/MAPK4 signaling"], "Q16186": ["UCH proteinases", "Ub-specific processing proteases"], "Q16222": ["Synthesis of UDP-N-acetyl-glucosamine"], "Q16254": ["Transcription of E2F targets under negative control by DREAM complex", "Transcription of E2F targets under negative control by DREAM complex", "Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1", "G0 and Early G1", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Activation of E2F1 target genes at G1/S", "Activation of E2F1 target genes at G1/S", "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "Cyclin E associated events during G1/S transition ", "Cyclin D associated events in G1", "Cyclin A:Cdk2-associated events at S phase entry"], "Q16270": ["Senescence-Associated Secretory Phenotype (SASP)", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "Q16280": ["VxPx cargo-targeting to cilium", "VxPx cargo-targeting to cilium"], "Q16288": ["Receptor-type tyrosine-protein phosphatases", "NTF3 activates NTRK3 signaling", "NTF3 activates NTRK3 signaling", "Signaling by NTRK3 (TRKC)", "Activated NTRK3 signals through PLCG1", "Activated NTRK3 signals through PLCG1", "Activated NTRK3 signals through RAS", "Activated NTRK3 signals through PI3K", "Activated NTRK3 signals through PI3K", "NTRK3 as a dependence receptor"], "Q16322": ["Voltage gated Potassium channels"], "Q16348": ["Proton/oligopeptide cotransporters"], "Q16363": ["Laminin interactions", "Laminin interactions", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "MET activates PTK2 signaling"], "Q16394": ["HS-GAG biosynthesis", "Defective EXT2 causes exostoses 2", "Defective EXT1 causes exostoses 1, TRPS2 and CHDS"], "Q16401": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q16445": ["GABA A receptor activation", "GABA receptor activation"], "Q16478": ["Activation of Ca-permeable Kainate Receptor"], "Q16512": ["RHO GTPases activate PKNs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3"], "Q16513": ["RHO GTPases activate PKNs"], "Q16514": ["HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "HATs acetylate histones", "RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "Q16515": ["Stimuli-sensing channels"], "Q16518": ["The canonical retinoid cycle in rods (twilight vision)"], "Q16520": ["Interleukin-4 and Interleukin-13 signaling"], "Q16526": ["Circadian Clock"], "Q16531": ["Recognition of DNA damage by PCNA-containing replication complex", "DNA Damage Recognition in GG-NER", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Neddylation"], "Q16533": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "Q16537": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Degradation of beta-catenin by the destruction complex", "Beta-catenin phosphorylation cascade", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "CTLA4 inhibitory signaling", "Platelet sensitization by LDL", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Misspliced GSK3beta mutants stabilize beta-catenin", "S33 mutants of beta-catenin aren't phosphorylated", "S37 mutants of beta-catenin aren't phosphorylated", "S45 mutants of beta-catenin aren't phosphorylated", "T41 mutants of beta-catenin aren't phosphorylated", "APC truncation mutants have impaired AXIN binding", "AXIN missense mutants destabilize the destruction complex", "Truncations of AMER1 destabilize the destruction complex", "RHO GTPases Activate Formins", "RAF activation", "Negative regulation of MAPK pathway", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Mitotic Prometaphase"], "Q16539": ["NOD1/2 Signaling Pathway", "p38MAPK events", "p38MAPK events", "ERK/MAPK targets", "Activation of PPARGC1A (PGC-1alpha) by phosphorylation", "Oxidative Stress Induced Senescence", "CDO in myogenesis", "CDO in myogenesis", "DSCAM interactions", "ADP signalling through P2Y purinoceptor 1", "Platelet sensitization by LDL", "VEGFA-VEGFR2 Pathway", "activated TAK1 mediates p38 MAPK activation", "Activation of the AP-1 family of transcription factors", "KSRP (KHSRP) binds and destabilizes mRNA", "RHO GTPases Activate NADPH Oxidases", "Neutrophil degranulation", "Regulation of TP53 Activity through Phosphorylation"], "Q16540": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q16543": ["Signaling by ERBB2", "Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "Constitutive Signaling by EGFRvIII", "Downregulation of ERBB2 signaling"], "Q16552": ["Interleukin-17 signaling", "Interleukin-4 and Interleukin-13 signaling"], "Q16553": ["Post-translational modification: synthesis of GPI-anchored proteins"], "Q16555": ["CRMPs in Sema3A signaling", "Recycling pathway of L1"], "Q16557": ["Cell surface interactions at the vascular wall"], "Q16558": ["Ca2+ activated K+ channels", "cGMP effects"], "Q16560": ["mRNA Splicing - Minor Pathway"], "Q16566": ["CaMK IV-mediated phosphorylation of CREB", "CaMK IV-mediated phosphorylation of CREB", "Transcriptional activation of mitochondrial biogenesis", "CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "Loss of phosphorylation of MECP2 at T308", "Regulation of MECP2 expression and activity", "Negative regulation of NMDA receptor-mediated neuronal transmission"], "Q16570": ["Peptide ligand-binding receptors"], "Q16572": ["Acetylcholine Neurotransmitter Release Cycle", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "Q16576": ["PRC2 methylates histones and DNA", "Oxidative Stress Induced Senescence", "HDACs deacetylate histones", "PKMTs methylate histone lysines", "HATs acetylate histones", "RMTs methylate histone arginines", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Deposition of new CENPA-containing nucleosomes at the centromere", "Regulation of TP53 Activity through Acetylation", "RNA Polymerase I Transcription Initiation", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription", "Neddylation", "Transcriptional Regulation by E2F6"], "Q16581": ["Peptide ligand-binding receptors", "G alpha (i) signalling events", "Neutrophil degranulation", "Regulation of Complement cascade"], "Q16584": ["RAF activation", "Signaling by moderate kinase activity BRAF mutants", "Signaling by RAS mutants", "Paradoxical activation of RAF signaling by kinase inactive BRAF"], "Q16587": ["Generic Transcription Pathway"], "Q16589": ["FOXO-mediated transcription of cell cycle genes"], "Q16594": ["HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "HATs acetylate histones", "RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "Q16595": ["Mitochondrial protein import", "Mitochondrial protein import", "Mitochondrial iron-sulfur cluster biogenesis"], "Q16602": ["G alpha (s) signalling events", "Calcitonin-like ligand receptors"], "Q16610": ["Platelet degranulation "], "Q16611": ["Activation and oligomerization of BAK protein", "Release of apoptotic factors from the mitochondria"], "Q16613": ["Serotonin and melatonin biosynthesis"], "Q16619": ["IL-6-type cytokine receptor ligand interactions"], "Q16620": ["NGF-independant TRKA activation", "BDNF activates NTRK2 (TRKB) signaling", "NTF3 activates NTRK2 (TRKB) signaling", "NTF4 activates NTRK2 (TRKB) signaling", "Activated NTRK2 signals through RAS", "Activated NTRK2 signals through PLCG1", "Activated NTRK2 signals through PLCG1", "Activated NTRK2 signals through PI3K", "Activated NTRK2 signals through FRS2 and FRS3", "Activated NTRK2 signals through FRS2 and FRS3", "Activated NTRK2 signals through FYN", "NTRK2 activates RAC1", "NTRK2 activates RAC1", "Activated NTRK2 signals through CDK5"], "Q16621": ["RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Factors involved in megakaryocyte development and platelet production", "Factors involved in megakaryocyte development and platelet production"], "Q16623": ["Serotonin Neurotransmitter Release Cycle", "Norepinephrine Neurotransmitter Release Cycle", "Glutamate Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle", "Acetylcholine Neurotransmitter Release Cycle", "Insulin processing", "Regulation of insulin secretion", "Other interleukin signaling", "Toxicity of botulinum toxin type C (BoNT/C)", "LGI-ADAM interactions", "Neurexins and neuroligins", "GABA synthesis, release, reuptake and degradation"], "Q16625": ["Apoptotic cleavage of cell adhesion proteins", "RUNX1 regulates expression of components of tight junctions"], "Q16629": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "mRNA 3'-end processing"], "Q16630": ["Signaling by cytosolic FGFR1 fusion mutants", "Signaling by FGFR1 in disease"], "Q16635": ["Mitochondrial protein import", "Mitochondrial protein import", "Acyl chain remodeling of CL"], "Q16637": ["snRNP Assembly"], "Q16644": ["p38MAPK events", "Oxidative Stress Induced Senescence", "VEGFA-VEGFR2 Pathway", "activated TAK1 mediates p38 MAPK activation"], "Q16647": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of bile acids and bile salts via 24-hydroxycholesterol", "Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "Nicotinamide salvaging", "Eicosanoids", "Sterols are 12-hydroxylated by CYP8B1", "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"], "Q16649": ["Circadian Clock"], "Q16651": ["Formation of the cornified envelope"], "Q16654": ["Regulation of pyruvate dehydrogenase (PDH) complex", "Signaling by Retinoic Acid"], "Q16656": ["PPARA activates gene expression", "Transcriptional activation of mitochondrial biogenesis", "Transcriptional activation of mitochondrial biogenesis"], "Q16658": ["Interleukin-4 and Interleukin-13 signaling"], "Q16659": ["MAPK6/MAPK4 signaling"], "Q16661": ["Digestion"], "Q16665": ["Regulation of gene expression by Hypoxia-inducible Factor", "Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "NOTCH1 Intracellular Domain Regulates Transcription", "Circadian Clock", "Ub-specific processing proteases", "Interleukin-4 and Interleukin-13 signaling", "PTK6 Expression", "PTK6 promotes HIF1A stabilization", "Neddylation"], "Q16666": ["STING mediated induction of host immune responses", "IRF3-mediated induction of type I IFN"], "Q16671": ["Signaling by BMP"], "Q16678": ["Endogenous sterols", "Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)", "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)", "Defective CYP1B1 causes Glaucoma"], "Q16690": ["RAF-independent MAPK1/3 activation", "Negative regulation of MAPK pathway"], "Q16695": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "Condensation of Prophase Chromosomes", "DNA Damage/Telomere Stress Induced Senescence", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "G2/M DNA damage checkpoint", "Meiotic recombination"], "Q16696": ["Fatty acids", "Xenobiotics", "CYP2E1 reactions", "Aflatoxin activation and detoxification"], "Q16698": ["mitochondrial fatty acid beta-oxidation of unsaturated fatty acids"], "Q16706": ["Intra-Golgi traffic", "Reactions specific to the complex N-glycan synthesis pathway"], "Q16718": ["Respiratory electron transport", "Complex I biogenesis"], "Q16719": ["Tryptophan catabolism"], "Q16720": ["Reduction of cytosolic Ca++ levels", "Ion homeostasis", "Ion transport by P-type ATPases"], "Q16739": ["Glycosphingolipid metabolism"], "Q16760": ["Effects of PIP2 hydrolysis"], "Q16762": ["Sulfide oxidation to sulfate", "Degradation of cysteine and homocysteine"], "Q16763": ["Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q16769": ["Neutrophil degranulation"], "Q16772": ["Glutathione conjugation"], "Q16773": ["Amino acid synthesis and interconversion (transamination)", "Phenylalanine and tyrosine catabolism", "Tryptophan catabolism"], "Q16774": ["Abacavir metabolism", "Interconversion of nucleotide di- and triphosphates"], "Q16775-2": ["Pyruvate metabolism"], "Q16777": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "HATs acetylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "UCH proteinases", "Ub-specific processing proteases", "Metalloprotease DUBs", "Deposition of new CENPA-containing nucleosomes at the centromere", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "Q16778": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "HATs acetylate histones", "HATs acetylate histones", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Ub-specific processing proteases", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "Q16787": ["Degradation of the extracellular matrix", "Degradation of the extracellular matrix", "Assembly of collagen fibrils and other multimeric structures", "Anchoring fibril formation", "Laminin interactions", "Laminin interactions", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "Type I hemidesmosome assembly", "MET activates PTK2 signaling"], "Q16790": ["Regulation of gene expression by Hypoxia-inducible Factor", "Reversible hydration of carbon dioxide"], "Q16795": ["Respiratory electron transport", "Complex I biogenesis"], "Q16798": ["Citric acid cycle (TCA cycle)"], "Q16816": ["Glycogen breakdown (glycogenolysis)", "Glycogen breakdown (glycogenolysis)"], "Q16822": ["Gluconeogenesis"], "Q16827": ["Signaling by NTRK3 (TRKC)"], "Q16828": ["RAF-independent MAPK1/3 activation", "ERKs are inactivated", "Negative regulation of MAPK pathway"], "Q16829": ["RAF-independent MAPK1/3 activation", "ERKs are inactivated", "Negative regulation of MAPK pathway"], "Q16831": ["Pyrimidine salvage", "Pyrimidine catabolism"], "Q16832": ["Non-integrin membrane-ECM interactions"], "Q16836": ["Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "Beta oxidation of hexanoyl-CoA to butanoyl-CoA", "Beta oxidation of butanoyl-CoA to acetyl-CoA"], "Q16842": ["Keratan sulfate biosynthesis", "Sialic acid metabolism", "Termination of O-glycan biosynthesis"], "Q16850": ["Cholesterol biosynthesis", "Endogenous sterols", "Activation of gene expression by SREBF (SREBP)"], "Q16851": ["Formation of the active cofactor, UDP-glucuronate", "Glycogen synthesis"], "Q16853": ["Phase I - Functionalization of compounds"], "Q16854": ["Purine salvage"], "Q16864": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "Q16873": ["Synthesis of 5-eicosatetraenoic acids", "Synthesis of Leukotrienes (LT) and Eoxins (EX)", "Synthesis of Lipoxins (LX)", "Biosynthesis of maresin conjugates in tissue regeneration (MCTR)", "Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR)"], "Q16875": ["Glycolysis"], "Q16877": ["Glycolysis"], "Q16878": ["Degradation of cysteine and homocysteine"], "Q16880": ["Glycosphingolipid metabolism"], "Q16881": ["PPARA activates gene expression", "Metabolism of ingested H2SeO4 and H2SeO3 into H2Se", "Detoxification of Reactive Oxygen Species", "Interconversion of nucleotide di- and triphosphates", "Metabolism of ingested MeSeO2H into MeSeH", "Uptake and function of diphtheria toxin", "TP53 Regulates Metabolic Genes"], "Q16890": ["Golgi Associated Vesicle Biogenesis"], "Q16891": ["Cristae formation"], "Q17R88": ["NFG and proNGF binds to p75NTR"], "Q17R89": ["Rho GTPase cycle"], "Q17RB8": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q17RR3": ["Digestion of dietary lipid"], "Q17RS7": ["Resolution of D-loop Structures through Holliday Junction Intermediates"], "Q17RW2": ["Collagen biosynthesis and modifying enzymes", "Assembly of collagen fibrils and other multimeric structures", "MET activates PTK2 signaling", "Collagen chain trimerization"], "Q17RY6": ["Post-translational modification: synthesis of GPI-anchored proteins"], "Q1EHB4": ["Multifunctional anion exchangers"], "Q1ZYL8": ["Sperm:Oocyte Membrane Binding"], "Q24JP5": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "Q29718": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "Q29836": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "Q29865": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "Q29940": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "Q29960": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "Q29963": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "Q29974": ["Downstream TCR signaling", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "MHC class II antigen presentation", "PD-1 signaling", "Interferon gamma signaling"], "Q29980": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "Q29983": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "Q29RF7": ["Separation of Sister Chromatids", "Establishment of Sister Chromatid Cohesion", "Cohesin Loading onto Chromatin", "Resolution of Sister Chromatid Cohesion"], "Q2I0M5": ["Regulation of FZD by ubiquitination"], "Q2KJY2": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "Q2M1P5": ["Hedgehog 'off' state", "Hedgehog 'on' state"], "Q2M1Z3": ["Rho GTPase cycle"], "Q2M2I5": ["Keratinization", "Formation of the cornified envelope"], "Q2M2I8": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "Q2M3G0": ["ABC-family proteins mediated transport"], "Q2M3M2": ["Cellular hexose transport"], "Q2M5E4": ["G alpha (q) signalling events", "G alpha (i) signalling events", "G alpha (i) signalling events"], "Q2MJR0": ["Regulation of RAS by GAPs", "Signaling by RAS mutants"], "Q2MKA7": ["Regulation of FZD by ubiquitination"], "Q2MV58": ["Anchoring of the basal body to the plasma membrane"], "Q2NKX8": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "Q2NL67": ["Nicotinamide salvaging"], "Q2NL82": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "Q2PPJ7": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane"], "Q2Q1W2": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q2QD12": ["Pentose phosphate pathway"], "Q2T9J0": ["Peroxisomal protein import", "Peroxisomal protein import", "TYSND1 cleaves peroxisomal proteins", "TYSND1 cleaves peroxisomal proteins"], "Q2TAA5": ["Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "Defective ALG11 causes ALG11-CDG (CDG-1p)"], "Q2TAC6": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "Q2UY09": ["Collagen biosynthesis and modifying enzymes", "Collagen chain trimerization"], "Q2VIQ3": ["MHC class II antigen presentation", "Recycling pathway of L1", "Recycling pathway of L1", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "Q2VPK5": ["tRNA modification in the nucleus and cytosol"], "Q2Y0W8": ["Bicarbonate transporters"], "Q2YD98": ["Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER"], "Q30134": ["Downstream TCR signaling", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "MHC class II antigen presentation", "PD-1 signaling", "Interferon gamma signaling"], "Q30154": ["Downstream TCR signaling", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "MHC class II antigen presentation", "PD-1 signaling", "Interferon gamma signaling"], "Q30167": ["Downstream TCR signaling", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "MHC class II antigen presentation", "PD-1 signaling", "Interferon gamma signaling"], "Q30201": ["Transferrin endocytosis and recycling"], "Q30KP8": ["Beta defensins", "Defensins"], "Q30KP9": ["Beta defensins", "Defensins"], "Q30KQ1": ["Beta defensins", "Defensins"], "Q30KQ3": ["Beta defensins", "Defensins"], "Q30KQ4": ["Beta defensins", "Defensins"], "Q30KQ5": ["Beta defensins", "Defensins"], "Q30KQ6": ["Beta defensins", "Defensins"], "Q30KQ7": ["Beta defensins", "Defensins"], "Q30KQ8": ["Beta defensins", "Defensins"], "Q30KQ9": ["Beta defensins", "Defensins"], "Q30KR1": ["Beta defensins"], "Q31610": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "Q31612": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "Q32M45": ["Stimuli-sensing channels"], "Q32M78": ["Generic Transcription Pathway"], "Q32MQ0": ["Generic Transcription Pathway"], "Q32MZ4": ["Signaling by cytosolic FGFR1 fusion mutants", "LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "Signaling by FGFR1 in disease"], "Q32NB8": ["Synthesis of PG"], "Q32P28": ["Collagen biosynthesis and modifying enzymes"], "Q32P41": ["Synthesis of wybutosine at G37 of tRNA(Phe)"], "Q32ZL2": ["Lysosphingolipid and LPA receptors"], "Q330K2": ["Complex I biogenesis"], "Q3B726": ["NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase I Transcription Termination"], "Q3E731": ["TP53 Regulates Metabolic Genes", "Respiratory electron transport"], "Q3I5F7": ["Beta-oxidation of very long chain fatty acids"], "Q3KNW5": ["Transport of bile salts and organic acids, metal ions and amine compounds"], "Q3KP31": ["Generic Transcription Pathway"], "Q3KQV3": ["Generic Transcription Pathway"], "Q3KRB8": ["Rho GTPase cycle"], "Q3L8U1": ["RORA activates gene expression", "BMAL1:CLOCK,NPAS2 activates circadian gene expression", "PPARA activates gene expression", "PPARA activates gene expression", "Transcriptional activation of mitochondrial biogenesis", "Activation of gene expression by SREBF (SREBP)", "Transcriptional regulation of white adipocyte differentiation", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)", "Circadian Clock"], "Q3LFD5": ["ISG15 antiviral mechanism"], "Q3LHN0": ["Keratinization"], "Q3LHN1": ["Keratinization"], "Q3LHN2": ["Keratinization"], "Q3LI54": ["Keratinization"], "Q3LI58": ["Keratinization"], "Q3LI59": ["Keratinization"], "Q3LI61": ["Keratinization"], "Q3LI63": ["Keratinization"], "Q3LI64": ["Keratinization"], "Q3LI66": ["Keratinization"], "Q3LI67": ["Keratinization"], "Q3LI70": ["Keratinization"], "Q3LI72": ["Keratinization"], "Q3LI73": ["Keratinization"], "Q3LI76": ["Keratinization"], "Q3LI77": ["Keratinization"], "Q3LI81": ["Keratinization"], "Q3LI83": ["Keratinization"], "Q3LIE5": ["Phosphate bond hydrolysis by NUDT proteins"], "Q3LXA3": ["DDX58/IFIH1-mediated induction of interferon-alpha/beta", "Fructose catabolism"], "Q3MII6": ["TBC/RABGAPs"], "Q3MIS6": ["Generic Transcription Pathway"], "Q3MIV0": ["Keratinization"], "Q3MJ16": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PS", "Acyl chain remodelling of PE", "Acyl chain remodelling of PI", "Hydrolysis of LPC"], "Q3MUY2": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "Q3SXY8": ["ARL13B-mediated ciliary trafficking of INPP5E"], "Q3SXZ3": ["Generic Transcription Pathway"], "Q3SXZ7": ["Carboxyterminal post-translational modifications of tubulin"], "Q3SY46": ["Keratinization"], "Q3SY52": ["Generic Transcription Pathway"], "Q3SY69": ["Metabolism of folate and pterines"], "Q3SY77": ["Glucuronidation"], "Q3SY84": ["Keratinization", "Formation of the cornified envelope"], "Q3SY89": ["Formation of RNA Pol II elongation complex ", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "RNA Polymerase II Transcription Elongation"], "Q3SYC2": ["Triglyceride biosynthesis"], "Q3SYF9": ["Keratinization"], "Q3SYG4": ["BBSome-mediated cargo-targeting to cilium"], "Q3ZCM7": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "Gap junction assembly", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Recruitment of NuMA to mitotic centrosomes", "Recycling pathway of L1", "Recycling pathway of L1", "Cilium Assembly", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "Carboxyterminal post-translational modifications of tubulin", "Carboxyterminal post-translational modifications of tubulin", "Activation of AMPK downstream of NMDARs", "Kinesins"], "Q3ZCQ8": ["Mitochondrial protein import"], "Q3ZCX4": ["Generic Transcription Pathway"], "Q45877": ["Toxicity of botulinum toxin type B (BoNT/B)", "Toxicity of botulinum toxin type A (BoNT/A)"], "Q45878": ["Toxicity of botulinum toxin type B (BoNT/B)", "Toxicity of botulinum toxin type A (BoNT/A)"], "Q460N5": ["Nicotinamide salvaging"], "Q495M3": ["Amino acid transport across the plasma membrane", "Proton-coupled neutral amino acid transporters", "Defective SLC36A2 causes iminoglycinuria (IG) and hyperglycinuria (HG)"], "Q496F6": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "DAP12 interactions"], "Q496H8": ["Post-translational modification: synthesis of GPI-anchored proteins"], "Q496J9": ["Toxicity of botulinum toxin type D (BoNT/D)", "Toxicity of botulinum toxin type A (BoNT/A)", "Toxicity of botulinum toxin type F (BoNT/F)"], "Q49A17": ["O-linked glycosylation of mucins"], "Q49AA0": ["Generic Transcription Pathway"], "Q49AN0": ["Circadian Clock"], "Q49B96": ["Mitochondrial protein import"], "Q4AC94": ["Anchoring of the basal body to the plasma membrane"], "Q4ADV7": ["Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network", "RAB GEFs exchange GTP for GDP on RABs"], "Q4FZB7": ["PKMTs methylate histone lysines"], "Q4G0N4": ["Nicotinate metabolism"], "Q4G0N8": ["Stimuli-sensing channels"], "Q4G176": ["Synthesis of very long-chain fatty acyl-CoAs"], "Q4JDL3": ["Interleukin-37 signaling"], "Q4KMG0": ["CDO in myogenesis", "CDO in myogenesis", "Ligand-receptor interactions", "Activation of SMO"], "Q4KMP7": ["TBC/RABGAPs"], "Q4KMQ2": ["Stimuli-sensing channels", "Neutrophil degranulation"], "Q4KWH8": ["Synthesis of IP3 and IP4 in the cytosol"], "Q4LE39": ["HDACs deacetylate histones", "NoRC negatively regulates rRNA expression"], "Q4QY38": ["Beta defensins", "Defensins"], "Q4U2R6": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q4U2R8": ["Organic anion transport"], "Q4V348": ["Generic Transcription Pathway"], "Q4VCS5-1": ["Signaling by Hippo"], "Q4VNC0": ["Ion transport by P-type ATPases"], "Q4VNC1": ["Ion transport by P-type ATPases"], "Q4ZG55": ["Estrogen-dependent gene expression"], "Q4ZJI4": ["Stimuli-sensing channels"], "Q504Q3": ["Deadenylation of mRNA"], "Q52LA3": ["Transcription of E2F targets under negative control by DREAM complex", "Transcription of E2F targets under negative control by DREAM complex", "Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1", "G0 and Early G1", "Polo-like kinase mediated events", "Activation of E2F1 target genes at G1/S", "Cyclin E associated events during G1/S transition ", "Cyclin A:Cdk2-associated events at S phase entry"], "Q52LG2": ["Keratinization"], "Q52LJ0": ["tRNA processing in the nucleus"], "Q52LW3": ["Rho GTPase cycle"], "Q52M93": ["Generic Transcription Pathway"], "Q53EL6": ["Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "Q53ET0": ["Transcriptional activation of mitochondrial biogenesis", "Circadian Clock"], "Q53EU6": ["Synthesis of PA"], "Q53FA7": ["TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain"], "Q53FT3": ["Regulation of HSF1-mediated heat shock response"], "Q53FV1": ["Sphingolipid de novo biosynthesis"], "Q53FZ2": ["Beta oxidation of butanoyl-CoA to acetyl-CoA"], "Q53G59": ["Degradation of DVL"], "Q53GD3": ["Synthesis of PC", "Transport of bile salts and organic acids, metal ions and amine compounds"], "Q53GI3": ["Generic Transcription Pathway"], "Q53GL7": ["Nicotinamide salvaging"], "Q53GQ0": ["Androgen biosynthesis", "Synthesis of very long-chain fatty acyl-CoAs"], "Q53GS7": ["Transport of Mature mRNA derived from an Intron-Containing Transcript"], "Q53GS9": ["mRNA Splicing - Major Pathway"], "Q53GT1": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q53H12": ["Glycerophospholipid biosynthesis", "Signaling by BRAF and RAF fusions"], "Q53H54": ["Synthesis of wybutosine at G37 of tRNA(Phe)"], "Q53H76": ["Acyl chain remodelling of PS"], "Q53H96": ["Amino acid synthesis and interconversion (transamination)"], "Q53HL2": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA replication proteins", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "Q53HV7": ["Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "Cleavage of the damaged pyrimidine ", "Displacement of DNA glycosylase by APEX1"], "Q53QZ3": ["Rho GTPase cycle"], "Q53T94": ["SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase I Transcription Termination"], "Q53TN4": ["Iron uptake and transport"], "Q53TQ3": ["UCH proteinases", "DNA Damage Recognition in GG-NER"], "Q53ZZ1": ["TNFs bind their physiological receptors"], "Q562F6": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "Q56NI9": ["Establishment of Sister Chromatid Cohesion"], "Q57230": ["Toxicity of botulinum toxin type B (BoNT/B)", "Toxicity of botulinum toxin type A (BoNT/A)"], "Q587J7": ["PIWI-interacting RNA (piRNA) biogenesis"], "Q58A45": ["Deadenylation of mRNA"], "Q58EX2": ["SDK interactions"], "Q58HT5": ["Arachidonic acid metabolism", "Wax biosynthesis"], "Q58WW2": ["Neddylation"], "Q5BIV9": ["Post-translational modification: synthesis of GPI-anchored proteins"], "Q5BJF6": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "Q5BKT4": ["Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"], "Q5D862": ["Neutrophil degranulation"], "Q5DT21": ["Formation of the cornified envelope"], "Q5EBL8": ["Biotin transport and metabolism", "Vitamin B5 (pantothenate) metabolism", "Transport of vitamins, nucleosides, and related molecules", "Ion influx/efflux at host-pathogen interface", "Ion transport by P-type ATPases"], "Q5EE01": ["Deposition of new CENPA-containing nucleosomes at the centromere"], "Q5FBB7": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "Q5FVE4": ["Synthesis of very long-chain fatty acyl-CoAs"], "Q5FWF5": ["Establishment of Sister Chromatid Cohesion"], "Q5FYA8": ["Glycosphingolipid metabolism", "The activation of arylsulfatases"], "Q5FYB0": ["Glycosphingolipid metabolism", "The activation of arylsulfatases"], "Q5FYB1": ["Glycosphingolipid metabolism", "The activation of arylsulfatases"], "Q5GJ75": ["PI Metabolism"], "Q5GLZ8": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q5H8A3": ["Peptide ligand-binding receptors", "G alpha (q) signalling events", "G alpha (i) signalling events"], "Q5H8A4": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "Q5H9L4": ["HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "Q5H9R7": ["COPII-mediated vesicle transport"], "Q5H9S7": ["Neddylation"], "Q5HYA8": ["Anchoring of the basal body to the plasma membrane"], "Q5HYJ1": ["Synthesis of very long-chain fatty acyl-CoAs"], "Q5HYK3": ["Ubiquinol biosynthesis"], "Q5HYK7": ["Golgi Associated Vesicle Biogenesis"], "Q5HYK9": ["Generic Transcription Pathway"], "Q5I7T1": ["Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"], "Q5J5C9": ["Beta defensins", "Defensins"], "Q5JNZ3": ["Generic Transcription Pathway"], "Q5JPH6": ["Mitochondrial tRNA aminoacylation"], "Q5JPI9": ["Protein methylation"], "Q5JQS5": ["Olfactory Signaling Pathway"], "Q5JRA6": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Cargo concentration in the ER", "Post-translational protein phosphorylation"], "Q5JRS4": ["Olfactory Signaling Pathway"], "Q5JRX3": ["Mitochondrial protein import"], "Q5JS37": ["Neutrophil degranulation"], "Q5JSL3": ["Factors involved in megakaryocyte development and platelet production"], "Q5JSP0": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "Q5JT25": ["Intra-Golgi traffic", "RAB geranylgeranylation"], "Q5JTC6": ["Degradation of beta-catenin by the destruction complex", "Beta-catenin phosphorylation cascade", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Misspliced GSK3beta mutants stabilize beta-catenin", "S33 mutants of beta-catenin aren't phosphorylated", "S37 mutants of beta-catenin aren't phosphorylated", "S45 mutants of beta-catenin aren't phosphorylated", "T41 mutants of beta-catenin aren't phosphorylated", "APC truncation mutants have impaired AXIN binding", "AXIN missense mutants destabilize the destruction complex", "Truncations of AMER1 destabilize the destruction complex"], "Q5JTJ3": ["Mitochondrial protein import"], "Q5JTW2": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "Q5JTZ9": ["Mitochondrial tRNA aminoacylation"], "Q5JUW0": ["Generic Transcription Pathway"], "Q5JV73": ["Neutrophil degranulation"], "Q5JVG2": ["Generic Transcription Pathway"], "Q5JVG8": ["Generic Transcription Pathway"], "Q5JVS0": ["Platelet degranulation "], "Q5JWF2": ["Glucagon signaling in metabolic regulation", "PKA activation in glucagon signalling", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Prostacyclin signalling through prostacyclin receptor", "Prostacyclin signalling through prostacyclin receptor", "G alpha (s) signalling events", "G alpha (s) signalling events", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Vasopressin regulates renal water homeostasis via Aquaporins", "Hedgehog 'off' state"], "Q5JXX5": ["Neurotransmitter receptors and postsynaptic signal transmission"], "Q5JZY3": ["EPH-Ephrin signaling", "EPH-Ephrin signaling", "EPHA-mediated growth cone collapse", "EPHA-mediated growth cone collapse", "EPH-ephrin mediated repulsion of cells", "EPH-ephrin mediated repulsion of cells"], "Q5K4L6": ["Synthesis of very long-chain fatty acyl-CoAs"], "Q5KSL6": ["Effects of PIP2 hydrolysis"], "Q5KU26": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Scavenging by Class A Receptors"], "Q5MCW4": ["Generic Transcription Pathway"], "Q5MNZ6": ["Macroautophagy"], "Q5MNZ9": ["Macroautophagy", "XBP1(S) activates chaperone genes"], "Q5MY95": ["Phosphate bond hydrolysis by NTPDase proteins"], "Q5NUL3": ["Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "G alpha (q) signalling events", "Free fatty acid receptors"], "Q5NV61": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "Regulation of Complement cascade"], "Q5NV62": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "Regulation of Complement cascade"], "Q5NV64": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "Regulation of Complement cascade"], "Q5NV65": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "Regulation of Complement cascade"], "Q5NV66": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "Regulation of Complement cascade"], "Q5NV67": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "Regulation of Complement cascade"], "Q5NV68": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "Regulation of Complement cascade"], "Q5NV69": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "Regulation of Complement cascade"], "Q5NV75": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "Regulation of Complement cascade"], "Q5NV79": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "Regulation of Complement cascade"], "Q5NV80": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "Regulation of Complement cascade"], "Q5NV81": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "Regulation of Complement cascade"], "Q5NV82": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "Regulation of Complement cascade"], "Q5NV83": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "Regulation of Complement cascade"], "Q5NV84": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "Regulation of Complement cascade"], "Q5NV85": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "Regulation of Complement cascade"], "Q5NV86": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "Regulation of Complement cascade"], "Q5NV87": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "Regulation of Complement cascade"], "Q5NV89": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "Regulation of Complement cascade"], "Q5NV90": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "Regulation of Complement cascade"], "Q5NV91": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "Regulation of Complement cascade"], "Q5NV92": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "Regulation of Complement cascade"], "Q5QGT7": ["Olfactory Signaling Pathway"], "Q5QGZ9": ["Neutrophil degranulation"], "Q5QJU3": ["Sphingolipid de novo biosynthesis"], "Q5QNW6": ["HDACs deacetylate histones", "HATs acetylate histones", "HATs acetylate histones", "Ub-specific processing proteases"], "Q5QP82": ["Neddylation"], "Q5RI15": ["TP53 Regulates Metabolic Genes", "Respiratory electron transport"], "Q5RKV6": ["ATF4 activates genes", "mRNA decay by 3' to 5' exoribonuclease", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "KSRP (KHSRP) binds and destabilizes mRNA", "Major pathway of rRNA processing in the nucleolus and cytosol"], "Q5S007": ["PTK6 promotes HIF1A stabilization"], "Q5SGD2": ["Sphingolipid de novo biosynthesis"], "Q5SQ64": ["Platelet degranulation "], "Q5SQI0": ["Cilium Assembly"], "Q5SRE5": ["ISG15 antiviral mechanism", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "tRNA processing in the nucleus"], "Q5SRI9": ["N-glycan trimming and elongation in the cis-Golgi"], "Q5SSG8": ["Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)", "Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)", "Defective GALNT12 causes colorectal cancer 1 (CRCS1)", "Dectin-2 family", "O-linked glycosylation of mucins", "Termination of O-glycan biosynthesis"], "Q5ST30": ["Mitochondrial tRNA aminoacylation"], "Q5SV97": ["Transcriptional activation of mitochondrial biogenesis"], "Q5SW96": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "Chylomicron clearance", "LDL clearance"], "Q5SXM1": ["Generic Transcription Pathway"], "Q5SXM2": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "Q5SY16": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "Q5SYC1": ["Lysosome Vesicle Biogenesis"], "Q5SZD4": ["Conjugation of salicylate with glycine", "Conjugation of benzoate with glycine"], "Q5T084": ["Digestion of dietary carbohydrate"], "Q5T0N5": ["Clathrin-mediated endocytosis"], "Q5T160": ["Mitochondrial tRNA aminoacylation"], "Q5T1C6": ["PIP3 activates AKT signaling", "Activation of AKT2", "Negative regulation of the PI3K/AKT network", "CD28 dependent PI3K/Akt signaling", "VEGFR2 mediated vascular permeability", "Mitochondrial Fatty Acid Beta-Oxidation"], "Q5T1R4": ["Regulation of RUNX2 expression and activity"], "Q5T2D2": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "Q5T2D3": ["Ovarian tumor domain proteases", "Regulation of PTEN stability and activity"], "Q5T2R2": ["Ubiquinol biosynthesis"], "Q5T3U5": ["ABC-family proteins mediated transport"], "Q5T442": ["Gap junction assembly"], "Q5T447": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q5T4S7": ["Neutrophil degranulation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q5T4W7": ["NCAM1 interactions", "RAF/MAP kinase cascade", "RET signaling"], "Q5T5A8": ["Formation of the cornified envelope"], "Q5T5B0": ["Formation of the cornified envelope"], "Q5T5D7": ["Generic Transcription Pathway"], "Q5T5U3": ["Rho GTPase cycle"], "Q5T653": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q5T6S3": ["PRC2 methylates histones and DNA"], "Q5T6X5": ["G alpha (q) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "Q5T751": ["Formation of the cornified envelope"], "Q5T752": ["Formation of the cornified envelope"], "Q5T753": ["Formation of the cornified envelope"], "Q5T754": ["Formation of the cornified envelope"], "Q5T7B8": ["Anchoring of the basal body to the plasma membrane"], "Q5T7P2": ["Formation of the cornified envelope"], "Q5T7P3": ["Formation of the cornified envelope"], "Q5T871": ["Formation of the cornified envelope"], "Q5T8D3": ["Peroxisomal lipid metabolism"], "Q5T8I9": ["PIWI-interacting RNA (piRNA) biogenesis"], "Q5T9A4": ["Neutrophil degranulation"], "Q5T9L3": ["WNT ligand biogenesis and trafficking"], "Q5TA45": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes"], "Q5TA50": ["Glycosphingolipid metabolism"], "Q5TA76": ["Formation of the cornified envelope"], "Q5TA77": ["Formation of the cornified envelope"], "Q5TA78": ["Formation of the cornified envelope"], "Q5TA79": ["Formation of the cornified envelope"], "Q5TA81": ["Formation of the cornified envelope"], "Q5TA82": ["Formation of the cornified envelope"], "Q5TA89": ["NOTCH1 Intracellular Domain Regulates Transcription", "NOTCH2 intracellular domain regulates transcription", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "NOTCH3 Intracellular Domain Regulates Transcription", "NOTCH4 Intracellular Domain Regulates Transcription"], "Q5TAH2": ["Stimuli-sensing channels"], "Q5TAP6": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "Q5TAQ9": ["Neddylation"], "Q5TAT6": ["Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Integrin cell surface interactions", "Collagen chain trimerization"], "Q5TAX3": ["Deadenylation of mRNA"], "Q5TB80": ["Anchoring of the basal body to the plasma membrane"], "Q5TCH4": ["Fatty acids", "Miscellaneous substrates", "Eicosanoids", "Synthesis of Leukotrienes (LT) and Eoxins (EX)"], "Q5TCM9": ["Formation of the cornified envelope"], "Q5TCS8": ["Interconversion of nucleotide di- and triphosphates"], "Q5TCZ1": ["Invadopodia formation"], "Q5TEC3": ["Generic Transcription Pathway"], "Q5TEU4": ["Complex I biogenesis"], "Q5TF39": ["Cellular hexose transport"], "Q5TG30": ["Rho GTPase cycle"], "Q5TGZ0": ["Cristae formation"], "Q5TKA1": ["Transcription of E2F targets under negative control by DREAM complex", "Transcription of E2F targets under negative control by DREAM complex", "Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1", "G0 and Early G1", "Polo-like kinase mediated events", "Activation of E2F1 target genes at G1/S", "Cyclin E associated events during G1/S transition ", "Cyclin A:Cdk2-associated events at S phase entry"], "Q5TYW1": ["Generic Transcription Pathway"], "Q5TZ20": ["Olfactory Signaling Pathway"], "Q5U5Q3": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q5U5R9": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q5U5Z8": ["Carboxyterminal post-translational modifications of tubulin"], "Q5UE93": ["GPVI-mediated activation cascade", "Synthesis of PIPs at the plasma membrane", "G beta:gamma signalling through PI3Kgamma"], "Q5UIP0": ["Nonhomologous End-Joining (NHEJ)"], "Q5VIR6": ["Retrograde transport at the Trans-Golgi-Network"], "Q5VIY5": ["Generic Transcription Pathway"], "Q5VST9": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "Q5VT52": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes"], "Q5VT66": ["Phase I - Functionalization of compounds"], "Q5VT97": ["Rho GTPase cycle"], "Q5VTB9": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q5VTE0": ["Eukaryotic Translation Elongation"], "Q5VTR2": ["E3 ubiquitin ligases ubiquitinate target proteins"], "Q5VTY9": ["Hedgehog ligand biogenesis", "HHAT G278V abrogates palmitoylation of Hh-Np"], "Q5VU57": ["Carboxyterminal post-translational modifications of tubulin"], "Q5VV41": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "Q5VV42": ["tRNA modification in the nucleus and cytosol"], "Q5VV43": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "Q5VV52": ["Generic Transcription Pathway"], "Q5VV67": ["Transcriptional activation of mitochondrial biogenesis"], "Q5VVJ2": ["Metalloprotease DUBs"], "Q5VVQ6": ["Ovarian tumor domain proteases"], "Q5VVX9": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q5VWC8": ["Synthesis of very long-chain fatty acyl-CoAs"], "Q5VWG9": ["HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "Q5VWK5": ["Interleukin-4 and Interleukin-13 signaling", "Interleukin-23 signaling", "Interleukin-23 signaling"], "Q5VWQ8": ["Regulation of RAS by GAPs", "Signaling by RAS mutants"], "Q5VWX1": ["PTK6 Regulates Proteins Involved in RNA Processing"], "Q5VXI9": ["Formation of the cornified envelope"], "Q5VXJ0": ["Formation of the cornified envelope"], "Q5VY80": ["Post-translational modification: synthesis of GPI-anchored proteins"], "Q5VYS8": ["Deadenylation of mRNA"], "Q5VYX0": ["Nicotinamide salvaging"], "Q5VYY2": ["Formation of the cornified envelope"], "Q5VZ72": ["Sperm:Oocyte Membrane Binding"], "Q5VZ89": ["RAB GEFs exchange GTP for GDP on RABs"], "Q5VZE5": ["Retrograde transport at the Trans-Golgi-Network"], "Q5VZK9": ["Factors involved in megakaryocyte development and platelet production"], "Q5VZM2": ["Macroautophagy", "mTOR signalling", "mTORC1-mediated signalling", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Regulation of PTEN gene transcription"], "Q5VZY2": ["Role of phospholipids in phagocytosis"], "Q5W064": ["Formation of the cornified envelope"], "Q5XG87": ["Signaling by BRAF and RAF fusions"], "Q5XKE5": ["Keratinization", "Formation of the cornified envelope"], "Q5XKP0": ["Cristae formation"], "Q5XPI4": ["Ub-specific processing proteases", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q5XUX0": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q5XUX1": ["Association of TriC/CCT with target proteins during biosynthesis", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q5XX13": ["Association of TriC/CCT with target proteins during biosynthesis", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q5XXA6": ["Stimuli-sensing channels"], "Q5Y7A7": ["Downstream TCR signaling", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "MHC class II antigen presentation", "PD-1 signaling", "Interferon gamma signaling"], "Q60393": ["Toxicity of botulinum toxin type G (BoNT/G)"], "Q60I27": ["RAB GEFs exchange GTP for GDP on RABs"], "Q63HM1": ["Tryptophan catabolism"], "Q63HN8": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q643R3": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PS", "Acyl chain remodelling of PE", "Acyl chain remodelling of PG", "Synthesis of PA"], "Q658P3": ["TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "Transferrin endocytosis and recycling"], "Q659A1": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes"], "Q66GS9": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "Q66K46": ["MHC class II antigen presentation", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "Q66LE6": ["MASTL Facilitates Mitotic Progression"], "Q674R7": ["Macroautophagy"], "Q674X7": ["Formation of the cornified envelope"], "Q676U5": ["Macroautophagy", "Macroautophagy"], "Q67FW5": ["O-linked glycosylation of mucins"], "Q684P5": ["Rap1 signalling"], "Q685J3": ["Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)", "Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)", "Defective GALNT12 causes colorectal cancer 1 (CRCS1)", "Dectin-2 family", "O-linked glycosylation of mucins", "Termination of O-glycan biosynthesis"], "Q68CJ9": ["CREB3 factors activate genes", "Assembly of active LPL and LIPC lipase complexes"], "Q68CK6": ["Conjugation of salicylate with glycine", "Conjugation of benzoate with glycine", "Conjugation of phenylacetate with glutamine"], "Q68CL5": ["Carboxyterminal post-translational modifications of tubulin"], "Q68CP4": ["HS-GAG degradation", "MPS IIIC - Sanfilippo syndrome C", "Neutrophil degranulation"], "Q68CP9": ["RMTs methylate histone arginines", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "Q68CQ4": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "Q68CZ1": ["Hedgehog 'off' state", "Anchoring of the basal body to the plasma membrane"], "Q68CZ2": ["MET interacts with TNS proteins"], "Q68CZ6": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "Q68D51": ["RAB GEFs exchange GTP for GDP on RABs"], "Q68D85": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "Q68DD2": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PS", "Acyl chain remodelling of PE", "Acyl chain remodelling of PI", "Acyl chain remodelling of PG", "Hydrolysis of LPC"], "Q68DI1": ["Generic Transcription Pathway"], "Q68DK7": ["HATs acetylate histones"], "Q68DV7": ["Regulation of FZD by ubiquitination", "RNF mutants show enhanced WNT signaling and proliferation"], "Q68DY1": ["Generic Transcription Pathway"], "Q68DY9": ["Generic Transcription Pathway"], "Q68E01": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes"], "Q68EM7": ["Rho GTPase cycle"], "Q695T7": ["Amino acid transport across the plasma membrane", "Na+/Cl- dependent neurotransmitter transporters", "Defective SLC6A19 causes Hartnup disorder (HND)", "Defective SLC6A19 causes Hartnup disorder (HND)"], "Q6A162": ["Keratinization", "Formation of the cornified envelope"], "Q6A163": ["Keratinization", "Formation of the cornified envelope"], "Q6AI14": ["Sodium/Proton exchangers"], "Q6AW86": ["Generic Transcription Pathway"], "Q6AZW8": ["Generic Transcription Pathway"], "Q6AZZ1": ["Interferon gamma signaling"], "Q6B0I6": ["HDMs demethylate histones"], "Q6BCY4": ["Erythrocytes take up carbon dioxide and release oxygen"], "Q6DHV7": ["Abacavir metabolism", "Purine salvage"], "Q6E213": ["Acyl chain remodeling of DAG and TAG", "The retinoid cycle in cones (daylight vision)", "Wax biosynthesis"], "Q6EBC2": ["IL-6-type cytokine receptor ligand interactions"], "Q6ECI4": ["Generic Transcription Pathway"], "Q6EIG7": ["Dectin-2 family", "Dectin-2 family"], "Q6EMB2": ["Carboxyterminal post-translational modifications of tubulin"], "Q6FI13": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "HATs acetylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "UCH proteinases", "Ub-specific processing proteases", "Metalloprotease DUBs", "Deposition of new CENPA-containing nucleosomes at the centromere", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "Q6FI81": ["Cytosolic iron-sulfur cluster assembly"], "Q6FIF0": ["Peroxisomal protein import", "Peroxisomal protein import"], "Q6GMR7": ["Arachidonic acid metabolism"], "Q6GPH4": ["Interferon alpha/beta signaling"], "Q6GPI1": ["Activation of Matrix Metalloproteinases", "Cobalamin (Cbl, vitamin B12) transport and metabolism"], "Q6GQQ9": ["TNFR1-induced proapoptotic signaling", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "Ovarian tumor domain proteases"], "Q6GTX8": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation"], "Q6H3X3": ["Post-translational modification: synthesis of GPI-anchored proteins"], "Q6H8Q1": ["DCC mediated attractive signaling"], "Q6I9Y2": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA 3'-end processing"], "Q6IA17": ["MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "Interleukin-37 signaling"], "Q6IA69": ["Nicotinate metabolism"], "Q6IA86": ["HATs acetylate histones"], "Q6IAA8": ["Macroautophagy", "mTOR signalling", "mTORC1-mediated signalling", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Neutrophil degranulation", "Regulation of PTEN gene transcription"], "Q6IB77": ["Conjugation of salicylate with glycine", "Conjugation of benzoate with glycine"], "Q6IBW4": ["Condensation of Prophase Chromosomes"], "Q6IE81": ["HATs acetylate histones"], "Q6IED9": ["Acyl chain remodeling of DAG and TAG"], "Q6IEG0": ["mRNA Splicing - Minor Pathway"], "Q6IEU7": ["Olfactory Signaling Pathway"], "Q6IEV9": ["Olfactory Signaling Pathway"], "Q6IEY1": ["Olfactory Signaling Pathway"], "Q6IEZ7": ["Olfactory Signaling Pathway"], "Q6IF00": ["Olfactory Signaling Pathway"], "Q6IF36": ["Olfactory Signaling Pathway"], "Q6IF42": ["Olfactory Signaling Pathway"], "Q6IF63": ["Olfactory Signaling Pathway"], "Q6IF82": ["Olfactory Signaling Pathway"], "Q6IF99": ["Olfactory Signaling Pathway"], "Q6IFG1": ["Olfactory Signaling Pathway"], "Q6IFH4": ["Olfactory Signaling Pathway"], "Q6IFN5": ["Olfactory Signaling Pathway"], "Q6IMI4": ["Cytosolic sulfonation of small molecules"], "Q6IN84": ["rRNA modification in the mitochondrion"], "Q6IPM2": ["Activation of SMO"], "Q6IPR3": ["Synthesis of wybutosine at G37 of tRNA(Phe)"], "Q6IPT4": ["Erythrocytes take up carbon dioxide and release oxygen"], "Q6IPU0": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Deposition of new CENPA-containing nucleosomes at the centromere", "Mitotic Prometaphase"], "Q6IQ16": ["Hedgehog 'on' state"], "Q6IQ20": ["Biosynthesis of A2E, implicated in retinal degradation"], "Q6IQ21": ["Generic Transcription Pathway"], "Q6IQ22": ["RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "Q6IQ26": ["RAB GEFs exchange GTP for GDP on RABs"], "Q6IQ55": ["Anchoring of the basal body to the plasma membrane"], "Q6IS24": ["O-linked glycosylation of mucins"], "Q6ISS4": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "Q6ISU1": ["NOTCH3 Intracellular Domain Regulates Transcription"], "Q6IV72": ["Generic Transcription Pathway"], "Q6IWH7": ["Stimuli-sensing channels"], "Q6J4K2": ["Sodium/Calcium exchangers", "Mitochondrial calcium ion transport"], "Q6JQN1": ["Mitochondrial Fatty Acid Beta-Oxidation"], "Q6JVE5": ["Transport of fatty acids"], "Q6KB66": ["Keratinization", "Formation of the cornified envelope"], "Q6KC79": ["Cohesin Loading onto Chromatin"], "Q6L8G4": ["Keratinization"], "Q6L8G5": ["Keratinization"], "Q6L8G8": ["Keratinization"], "Q6L8G9": ["Keratinization"], "Q6L8H1": ["Keratinization"], "Q6L8H2": ["Keratinization"], "Q6L8H4": ["Keratinization"], "Q6L8Q7": ["OAS antiviral response"], "Q6MZP7": ["Transcription of E2F targets under negative control by DREAM complex", "Transcription of E2F targets under negative control by DREAM complex", "Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1", "G0 and Early G1", "Polo-like kinase mediated events", "Activation of E2F1 target genes at G1/S", "Cyclin E associated events during G1/S transition ", "Cyclin A:Cdk2-associated events at S phase entry"], "Q6MZZ7": ["Degradation of the extracellular matrix"], "Q6N021": ["TET1,2,3 and TDG demethylate DNA"], "Q6NS38": ["ALKBH2 mediated reversal of alkylation damage"], "Q6NSJ5": ["Miscellaneous transport and binding events"], "Q6NSZ9": ["Generic Transcription Pathway"], "Q6NT55": ["Fatty acids", "Miscellaneous substrates", "Eicosanoids", "Synthesis of Leukotrienes (LT) and Eoxins (EX)", "Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5)"], "Q6NTF7": ["mRNA Editing: C to U Conversion", "Formation of the Editosome"], "Q6NUI2": ["Synthesis of PA", "Triglyceride biosynthesis"], "Q6NUK4": ["Olfactory Signaling Pathway"], "Q6NUM9": ["Retinoid metabolism and transport"], "Q6NUN0": ["Conjugation of salicylate with glycine"], "Q6NUN9": ["Generic Transcription Pathway"], "Q6NUQ1": ["COPI-dependent Golgi-to-ER retrograde traffic"], "Q6NUS6": ["Anchoring of the basal body to the plasma membrane"], "Q6NUS8": ["Glucuronidation"], "Q6NVV3": ["Miscellaneous transport and binding events"], "Q6NVY1": ["Branched-chain amino acid catabolism"], "Q6NW40": ["Netrin-1 signaling"], "Q6NX45": ["Generic Transcription Pathway"], "Q6NX49": ["Generic Transcription Pathway"], "Q6NXG1": ["Signaling by BRAF and RAF fusions", "FGFR2 alternative splicing"], "Q6NXT4": ["Insulin processing", "Zinc efflux and compartmentalization by the SLC30 family"], "Q6NYC1": ["HDMs demethylate histones"], "Q6NZ36": ["Fanconi Anemia Pathway"], "Q6NZ67": ["Recruitment of mitotic centrosome proteins and complexes", "Recruitment of NuMA to mitotic centrosomes"], "Q6NZI2": ["RNA Polymerase I Transcription Termination"], "Q6NZY7": ["MAPK6/MAPK4 signaling"], "Q6P050": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q6P0N0": ["Deposition of new CENPA-containing nucleosomes at the centromere"], "Q6P161": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q6P179": ["Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "Q6P1A2": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PS", "Acyl chain remodelling of PE"], "Q6P1J6": ["Acyl chain remodelling of PC", "Retinoid metabolism and transport"], "Q6P1J9": ["Formation of RNA Pol II elongation complex ", "Formation of the beta-catenin:TCF transactivating complex", "Hedgehog 'on' state", "RNA Polymerase II Pre-transcription Events", "RNA Polymerase II Transcription Elongation", "E3 ubiquitin ligases ubiquitinate target proteins"], "Q6P1K2": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "Q6P1L6": ["Generic Transcription Pathway"], "Q6P1L8": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q6P1M0": ["Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS)", "Transport of fatty acids"], "Q6P1X5": ["HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "Q6P280": ["Generic Transcription Pathway"], "Q6P2C8": ["PPARA activates gene expression", "Generic Transcription Pathway", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "Q6P2D0": ["Generic Transcription Pathway"], "Q6P2E9": ["mRNA decay by 5' to 3' exoribonuclease"], "Q6P2Q9": ["mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "Q6P3S1": ["RAB GEFs exchange GTP for GDP on RABs"], "Q6P3V2": ["Generic Transcription Pathway"], "Q6P3W2": ["Synthesis of diphthamide-EEF2"], "Q6P461": ["Beta oxidation of butanoyl-CoA to acetyl-CoA"], "Q6P499": ["Miscellaneous transport and binding events"], "Q6P4A8": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PE", "Acyl chain remodelling of PI", "Hydrolysis of LPC"], "Q6P4F2": ["Mitochondrial iron-sulfur cluster biogenesis", "Pregnenolone biosynthesis", "Endogenous sterols", "Electron transport from NADPH to Ferredoxin", "Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)"], "Q6P4F7": ["Rho GTPase cycle"], "Q6P4R8": ["UCH proteinases", "DNA Damage Recognition in GG-NER"], "Q6P531": ["Glutathione synthesis and recycling", "Aflatoxin activation and detoxification"], "Q6P582": ["Recruitment of mitotic centrosome proteins and complexes", "Recruitment of NuMA to mitotic centrosomes"], "Q6P587": ["Citric acid cycle (TCA cycle)"], "Q6P589": ["PI Metabolism"], "Q6P597": ["MHC class II antigen presentation", "RHO GTPases activate KTN1", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "Q6P5R6": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "Q6P5W5": ["Zinc influx into cells by the SLC39 gene family", "Defective SLC39A4 causes acrodermatitis enteropathica, zinc-deficiency type (AEZ)"], "Q6P5Z2": ["RHO GTPases activate PKNs"], "Q6P6C2": ["Reversal of alkylation damage by DNA dioxygenases"], "Q6P988": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Release of Hh-Np from the secreting cell", "Post-translational protein phosphorylation"], "Q6P9A1": ["Generic Transcription Pathway"], "Q6P9A2": ["O-linked glycosylation of mucins"], "Q6P9A3": ["Generic Transcription Pathway"], "Q6P9B9": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes"], "Q6P9F7": ["Miscellaneous transport and binding events"], "Q6PCB0": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "Q6PCB7": ["PPARA activates gene expression", "Transport of fatty acids"], "Q6PCB8": ["Proton-coupled monocarboxylate transport"], "Q6PCE3": ["Glycogen synthesis", "Glycolysis", "Glycogen breakdown (glycogenolysis)", "Galactose catabolism"], "Q6PCT2": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q6PD62": ["Formation of RNA Pol II elongation complex ", "RNA Polymerase II Pre-transcription Events", "RNA Polymerase II Transcription Elongation", "E3 ubiquitin ligases ubiquitinate target proteins"], "Q6PEX3": ["Keratinization"], "Q6PEY0": ["Gap junction assembly"], "Q6PEY2": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "Gap junction assembly", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Recruitment of NuMA to mitotic centrosomes", "Formation of tubulin folding intermediates by CCT/TriC", "Post-chaperonin tubulin folding pathway", "Recycling pathway of L1", "Recycling pathway of L1", "Cilium Assembly", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "Carboxyterminal post-translational modifications of tubulin", "Carboxyterminal post-translational modifications of tubulin", "Activation of AMPK downstream of NMDARs", "Kinesins"], "Q6PF04": ["Generic Transcription Pathway"], "Q6PFW1": ["Synthesis of pyrophosphates in the cytosol"], "Q6PG37": ["Generic Transcription Pathway"], "Q6PGP7": ["mRNA decay by 3' to 5' exoribonuclease"], "Q6PGQ7": ["Regulation of PLK1 Activity at G2/M Transition"], "Q6PH85": ["Neddylation"], "Q6PHR2": ["Hedgehog 'on' state"], "Q6PHW0": ["Thyroxine biosynthesis"], "Q6PI25": ["COPII-mediated vesicle transport", "Cargo concentration in the ER"], "Q6PI48": ["Mitochondrial tRNA aminoacylation"], "Q6PI73": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "Q6PI98": ["UCH proteinases", "DNA Damage Recognition in GG-NER"], "Q6PIF2": ["Meiotic synapsis"], "Q6PIL0": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "Fc epsilon receptor (FCERI) signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "Q6PIL6": ["Phase 1 - inactivation of fast Na+ channels"], "Q6PIU1": ["Voltage gated Potassium channels"], "Q6PIU2": ["LDL clearance"], "Q6PIZ9": ["PIP3 activates AKT signaling", "Downstream TCR signaling", "Constitutive Signaling by Aberrant PI3K in Cancer", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "Q6PJ21": ["Neddylation"], "Q6PJG9": ["Synaptic adhesion-like molecules"], "Q6PJP8": ["Fanconi Anemia Pathway"], "Q6PK81": ["Generic Transcription Pathway"], "Q6PKD1": ["MHC class II antigen presentation", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "Q6PKX4": ["RET signaling"], "Q6PL18": ["TFAP2 (AP-2) family regulates transcription of growth factors and their receptors"], "Q6PXP3": ["Cellular hexose transport"], "Q6Q0C0": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q6Q788": ["PPARA activates gene expression", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation", "Assembly of active LPL and LIPC lipase complexes", "Chylomicron remodeling"], "Q6QHC5": ["Sphingolipid de novo biosynthesis"], "Q6QHF9": ["PAOs oxidise polyamines to amines", "Interconversion of polyamines", "Peroxisomal protein import", "Peroxisomal protein import"], "Q6QNY0": ["Golgi Associated Vesicle Biogenesis"], "Q6R327": ["PIP3 activates AKT signaling", "CD28 dependent PI3K/Akt signaling", "VEGFR2 mediated vascular permeability", "Constitutive Signaling by AKT1 E17K in Cancer", "Regulation of TP53 Degradation"], "Q6R6M4": ["Ub-specific processing proteases"], "Q6RW13": ["Signaling by BRAF and RAF fusions"], "Q6STE5": ["RORA activates gene expression", "BMAL1:CLOCK,NPAS2 activates circadian gene expression", "PPARA activates gene expression", "PPARA activates gene expression", "Transcriptional activation of mitochondrial biogenesis", "Activation of gene expression by SREBF (SREBP)", "RMTs methylate histone arginines", "Transcriptional regulation of white adipocyte differentiation", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)", "Circadian Clock", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "Q6SZW1-1": ["MyD88-independent TLR4 cascade ", "Toll Like Receptor 3 (TLR3) Cascade", "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon", "IKK complex recruitment mediated by RIP1", "TRAF6-mediated induction of TAK1 complex within TLR4 complex"], "Q6T4P5": ["Lysosphingolipid and LPA receptors"], "Q6TCH7": ["Negative regulation of MAPK pathway"], "Q6TGC4": ["Chromatin modifying enzymes"], "Q6U736": ["G alpha (i) signalling events", "Opsins"], "Q6U841": ["Bicarbonate transporters"], "Q6UB35": ["Metabolism of folate and pterines"], "Q6UN15": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA Derived from an Intronless Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "Q6UQ28": ["Post-translational modification: synthesis of GPI-anchored proteins"], "Q6UUV7": ["Transcriptional activation of mitochondrial biogenesis", "Circadian Clock"], "Q6UUV9": ["Transcriptional activation of mitochondrial biogenesis", "Circadian Clock", "Circadian Clock"], "Q6UVK1": ["A tetrasaccharide linker sequence is required for GAG synthesis", "Chondroitin sulfate biosynthesis", "Dermatan sulfate biosynthesis", "CS/DS degradation", "Defective B4GALT7 causes EDS, progeroid type", "Defective B3GAT3 causes JDSSDHD", "Defective CHST3 causes SEDCJD", "Defective CHST14 causes EDS, musculocontractural type", "Defective CHSY1 causes TPBS", "Defective B3GALT6 causes EDSP2 and SEMDJL1"], "Q6UW15": ["Antimicrobial peptides"], "Q6UW88": ["PIP3 activates AKT signaling", "Signaling by EGFR", "GRB2 events in EGFR signaling", "GAB1 signalosome", "SHC1 events in EGFR signaling", "EGFR downregulation", "EGFR interacts with phospholipase C-gamma", "Constitutive Signaling by Aberrant PI3K in Cancer", "Inhibition of Signaling by Overexpressed EGFR", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "Q6UWB1": ["Interleukin-35 Signalling", "Interleukin-27 signaling", "Interleukin-27 signaling"], "Q6UWE0": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q6UWL6": ["Nephrin family interactions"], "Q6UWM9": ["Glucuronidation"], "Q6UWN0": ["Post-translational modification: synthesis of GPI-anchored proteins"], "Q6UWN5": ["Post-translational modification: synthesis of GPI-anchored proteins"], "Q6UWN8": ["Formation of the cornified envelope"], "Q6UWP7": ["Acyl chain remodeling of CL", "Synthesis of PA"], "Q6UWR7": ["Glycerophospholipid catabolism"], "Q6UWU2": ["Glycosphingolipid metabolism", "Keratan sulfate degradation", "HS-GAG degradation"], "Q6UWV6": ["Glycosphingolipid metabolism"], "Q6UWW0": ["Transport of fatty acids"], "Q6UWW8": ["Phase I - Functionalization of compounds", "LDL clearance"], "Q6UWY0": ["Glycosphingolipid metabolism", "The activation of arylsulfatases"], "Q6UWZ7": ["Metalloprotease DUBs", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "G2/M DNA damage checkpoint"], "Q6UX04": ["mRNA Splicing - Major Pathway"], "Q6UX06": ["Neutrophil degranulation"], "Q6UX39": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "Q6UX41": ["Butyrophilin (BTN) family interactions"], "Q6UX72": ["O-linked glycosylation of mucins"], "Q6UX82": ["Post-translational modification: synthesis of GPI-anchored proteins"], "Q6UXB3": ["Post-translational modification: synthesis of GPI-anchored proteins"], "Q6UXB4": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "Q6UXG3": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "Q6UXG8": ["Butyrophilin (BTN) family interactions"], "Q6UXH0": ["Assembly of active LPL and LIPC lipase complexes"], "Q6UXL0": ["Interleukin-20 family signaling"], "Q6UXN2": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "Q6UXV1": ["Sperm:Oocyte Membrane Binding"], "Q6UXV4": ["Platelet degranulation ", "Cristae formation"], "Q6UXX9": ["Regulation of FZD by ubiquitination"], "Q6UXZ3": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "Q6UXZ4": ["Netrin mediated repulsion signals"], "Q6UY14": ["Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "Q6V0L0": ["Vitamins", "RA biosynthesis pathway", "Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4)"], "Q6V9R5": ["Generic Transcription Pathway"], "Q6VAB6": ["MAP2K and MAPK activation", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF"], "Q6VMQ6": ["PKMTs methylate histone lysines"], "Q6VN20": ["MET activates RAS signaling"], "Q6VUC0": ["Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "Activation of the TFAP2 (AP-2) family of transcription factors"], "Q6VVB1": ["Glycogen synthesis", "Myoclonic epilepsy of Lafora"], "Q6VVX0": ["Vitamin D (calciferol) metabolism", "Vitamins", "Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B)"], "Q6VY07": ["Nef mediated downregulation of MHC class I complex cell surface expression"], "Q6W4X9": ["Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)", "Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)", "Defective GALNT12 causes colorectal cancer 1 (CRCS1)", "Dectin-2 family", "O-linked glycosylation of mucins", "Termination of O-glycan biosynthesis"], "Q6W5P4": ["Peptide ligand-binding receptors", "G alpha (q) signalling events", "G alpha (s) signalling events"], "Q6WBX8": ["Activation of ATR in response to replication stress", "HDR through Single Strand Annealing (SSA)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Regulation of TP53 Activity through Phosphorylation", "G2/M DNA damage checkpoint"], "Q6WCQ1": ["Signaling by BRAF and RAF fusions"], "Q6X9E4": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q6XPR3": ["Formation of the cornified envelope"], "Q6XPS3": ["Synthesis of PIPs at the Golgi membrane"], "Q6XQN6": ["Nicotinamide salvaging", "Neutrophil degranulation"], "Q6XR72": ["Metal ion SLC transporters"], "Q6XYQ8": ["Neurexins and neuroligins"], "Q6XZB0": ["Synthesis of PA"], "Q6Y1H2": ["Synthesis of very long-chain fatty acyl-CoAs"], "Q6Y288": ["Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "Q6YBV0": ["Amino acid transport across the plasma membrane", "Tryptophan catabolism"], "Q6YHK3": ["Platelet degranulation ", "Post-translational modification: synthesis of GPI-anchored proteins"], "Q6YHU6": ["tRNA modification in the nucleus and cytosol"], "Q6YP21": ["Tryptophan catabolism"], "Q6ZMB0": ["O-linked glycosylation of mucins"], "Q6ZMC9": ["DAP12 interactions"], "Q6ZMG9": ["Sphingolipid de novo biosynthesis"], "Q6ZMH5": ["Zinc influx into cells by the SLC39 gene family"], "Q6ZMJ2": ["Scavenging by Class A Receptors"], "Q6ZMJ4": ["Other interleukin signaling"], "Q6ZMM2": ["Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "Q6ZMP0": ["Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "Q6ZMR3": ["Pyruvate metabolism"], "Q6ZMT4": ["HDMs demethylate histones", "Signaling by BRAF and RAF fusions"], "Q6ZMU5": ["Smooth Muscle Contraction", "Smooth Muscle Contraction"], "Q6ZMV8": ["Generic Transcription Pathway"], "Q6ZMV9": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "Q6ZMW2": ["Generic Transcription Pathway"], "Q6ZMY9": ["Generic Transcription Pathway"], "Q6ZMZ0": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q6ZN11": ["Generic Transcription Pathway"], "Q6ZN18": ["PRC2 methylates histones and DNA", "PKMTs methylate histone lysines"], "Q6ZN44": ["Netrin-1 signaling", "Netrin mediated repulsion signals", "Caspase activation via Dependence Receptors in the absence of ligand"], "Q6ZN57": ["Generic Transcription Pathway"], "Q6ZN66": ["Interferon gamma signaling"], "Q6ZN79": ["Generic Transcription Pathway"], "Q6ZNA4": ["Downregulation of SMAD2/3:SMAD4 transcriptional activity", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Formation of Incision Complex in GG-NER", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q6ZNB7": ["Triglyceride biosynthesis"], "Q6ZNC4": ["Generic Transcription Pathway"], "Q6ZNC8": ["Acyl chain remodelling of PS", "Acyl chain remodelling of PE"], "Q6ZNE5": ["Macroautophagy"], "Q6ZNG0": ["Generic Transcription Pathway"], "Q6ZNG1": ["Generic Transcription Pathway"], "Q6ZNI0": ["O-linked glycosylation of mucins"], "Q6ZNJ1": ["Neutrophil degranulation"], "Q6ZP29": ["Miscellaneous transport and binding events"], "Q6ZPD8": ["Acyl chain remodeling of DAG and TAG"], "Q6ZQN7": ["Neutrophil degranulation", "Transport of organic anions"], "Q6ZQW0": ["Tryptophan catabolism"], "Q6ZQY3": ["Degradation of cysteine and homocysteine", "Amino acid synthesis and interconversion (transamination)"], "Q6ZR52": ["Generic Transcription Pathway"], "Q6ZRH7": ["Sperm Motility And Taxes"], "Q6ZRI8": ["Rho GTPase cycle"], "Q6ZS11": ["RAB GEFs exchange GTP for GDP on RABs"], "Q6ZS27": ["Generic Transcription Pathway"], "Q6ZS82": ["Inactivation, recovery and regulation of the phototransduction cascade", "Inactivation, recovery and regulation of the phototransduction cascade"], "Q6ZSI9": ["Degradation of the extracellular matrix"], "Q6ZSS3": ["Generic Transcription Pathway"], "Q6ZSZ5": ["NRAGE signals death through JNK", "Rho GTPase cycle", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "G alpha (12/13) signalling events"], "Q6ZT98": ["Carboxyterminal post-translational modifications of tubulin"], "Q6ZTW0": ["Carboxyterminal post-translational modifications of tubulin"], "Q6ZUJ8": ["PIP3 activates AKT signaling", "Constitutive Signaling by Aberrant PI3K in Cancer", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "Q6ZUM4": ["Rho GTPase cycle"], "Q6ZUT9": ["RAB GEFs exchange GTP for GDP on RABs"], "Q6ZUV0": ["Mitochondrial Fatty Acid Beta-Oxidation"], "Q6ZUX7": ["Platelet degranulation "], "Q6ZV29": ["Glycerophospholipid catabolism"], "Q6ZVD8": ["Negative regulation of the PI3K/AKT network"], "Q6ZVK8-1": ["Phosphate bond hydrolysis by NUDT proteins"], "Q6ZVN8": ["Netrin-1 signaling"], "Q6ZVT0": ["Carboxyterminal post-translational modifications of tubulin"], "Q6ZVZ8": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q6ZW31": ["Rho GTPase cycle"], "Q6ZW49": ["Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Nonhomologous End-Joining (NHEJ)"], "Q6ZW61": ["BBSome-mediated cargo-targeting to cilium"], "Q6ZWL3": ["Endogenous sterols", "The canonical retinoid cycle in rods (twilight vision)"], "Q6ZWT7": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PE"], "Q6ZYL4": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Tat-mediated elongation of the HIV-1 transcript", "NoRC negatively regulates rRNA expression", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "mRNA Capping", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase I Transcription Termination", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE"], "Q701N2": ["Keratinization"], "Q701N4": ["Keratinization"], "Q70626": ["Dectin-2 family"], "Q709F0": ["Mitochondrial Fatty Acid Beta-Oxidation"], "Q70CQ1": ["Ub-specific processing proteases"], "Q70CQ2": ["TCF dependent signaling in response to WNT", "Ub-specific processing proteases"], "Q70CQ3": ["Ub-specific processing proteases"], "Q70EL2": ["Formation of Incision Complex in GG-NER"], "Q70EL4": ["Termination of translesion DNA synthesis"], "Q70HW3": ["Transport of inorganic cations/anions and amino acids/oligopeptides"], "Q70J99": ["Neutrophil degranulation"], "Q70JA7": ["Chondroitin sulfate biosynthesis"], "Q70SY1": ["CREB3 factors activate genes"], "Q70Z35": ["Regulation of PTEN stability and activity"], "Q70Z44": ["Neurotransmitter receptors and postsynaptic signal transmission"], "Q712K3": ["Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q717R9": ["Trafficking of myristoylated proteins to the cilium"], "Q719H9": ["Negative regulation of activity of TFAP2 (AP-2) family transcription factors"], "Q71DI3": ["Interleukin-7 signaling", "Interleukin-7 signaling", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "HDACs deacetylate histones", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "Chromatin modifying enzymes", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation", "Factors involved in megakaryocyte development and platelet production"], "Q71F23": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Deposition of new CENPA-containing nucleosomes at the centromere", "Mitotic Prometaphase"], "Q71F56": ["PPARA activates gene expression", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "Q71RS6": ["Sodium/Calcium exchangers", "Defective SLC24A5 causes oculocutaneous albinism 6 (OCA6)"], "Q71SY5": ["PPARA activates gene expression", "Generic Transcription Pathway", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "Q71U36": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "Gap junction assembly", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Regulation of PLK1 Activity at G2/M Transition", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Prefoldin mediated transfer of substrate to CCT/TriC", "Formation of tubulin folding intermediates by CCT/TriC", "Post-chaperonin tubulin folding pathway", "Recycling pathway of L1", "Recycling pathway of L1", "Hedgehog 'off' state", "Cilium Assembly", "Anchoring of the basal body to the plasma membrane", "Intraflagellar transport", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "AURKA Activation by TPX2", "Carboxyterminal post-translational modifications of tubulin", "Carboxyterminal post-translational modifications of tubulin", "Activation of AMPK downstream of NMDARs", "Kinesins"], "Q71UI9": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Deposition of new CENPA-containing nucleosomes at the centromere", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination"], "Q71UM5": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "Q75MW2": ["Generic Transcription Pathway"], "Q75N03": ["InlA-mediated entry of Listeria monocytogenes into host cells"], "Q75N90": ["Degradation of the extracellular matrix", "Elastic fibre formation", "Molecules associated with elastic fibres", "Molecules associated with elastic fibres"], "Q75QN2": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes"], "Q75T13": ["Attachment of GPI anchor to uPAR"], "Q75V66": ["Stimuli-sensing channels"], "Q765I0": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "Q76EJ3": ["Keratan sulfate biosynthesis", "HS-GAG biosynthesis", "Transport of nucleotide sugars"], "Q76L83": ["UCH proteinases"], "Q76LX8": ["Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "Q76N89": ["Degradation of DVL"], "Q76NM5": ["Cell surface interactions at the vascular wall"], "Q76RF1": ["Caspase activation via Death Receptors in the presence of ligand"], "Q7D8E1": ["Cell redox homeostasis"], "Q7KYR7": ["Butyrophilin (BTN) family interactions"], "Q7KZ85": ["Formation of RNA Pol II elongation complex ", "RNA Polymerase II Pre-transcription Events", "RNA Polymerase II Transcription Elongation"], "Q7KZF4": ["Signaling by BRAF and RAF fusions"], "Q7KZN9": ["Heme biosynthesis"], "Q7L014": ["mRNA Splicing - Major Pathway"], "Q7L0J3": ["Toxicity of botulinum toxin type D (BoNT/D)", "Toxicity of botulinum toxin type A (BoNT/A)", "Toxicity of botulinum toxin type F (BoNT/F)", "Toxicity of botulinum toxin type E (BoNT/E)"], "Q7L0Q8": ["Rho GTPase cycle", "Interleukin-4 and Interleukin-13 signaling"], "Q7L0Y3": ["tRNA processing in the mitochondrion", "tRNA modification in the mitochondrion", "rRNA processing in the mitochondrion"], "Q7L190": ["POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation"], "Q7L1I2": ["Toxicity of botulinum toxin type D (BoNT/D)", "Toxicity of botulinum toxin type A (BoNT/A)", "Toxicity of botulinum toxin type F (BoNT/F)", "Toxicity of botulinum toxin type E (BoNT/E)"], "Q7L1S5-2": ["Chondroitin sulfate biosynthesis"], "Q7L1T6": ["Erythrocytes take up carbon dioxide and release oxygen"], "Q7L1V2": ["RAB GEFs exchange GTP for GDP on RABs"], "Q7L1W4": ["Miscellaneous transport and binding events"], "Q7L266": ["Phenylalanine and tyrosine catabolism"], "Q7L2H7": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "Q7L2Z9": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Deposition of new CENPA-containing nucleosomes at the centromere", "Mitotic Prometaphase"], "Q7L3B6": ["Platelet degranulation "], "Q7L3S4": ["Generic Transcription Pathway"], "Q7L3T8": ["Mitochondrial tRNA aminoacylation"], "Q7L4E1": ["Synthesis of PA"], "Q7L523": ["Macroautophagy", "mTOR signalling", "mTORC1-mediated signalling", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "E3 ubiquitin ligases ubiquitinate target proteins", "Regulation of PTEN gene transcription"], "Q7L576": ["Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs", "Neutrophil degranulation"], "Q7L590": ["Activation of ATR in response to replication stress", "Activation of the pre-replicative complex"], "Q7L591": ["Neutrophil degranulation"], "Q7L592": ["Complex I biogenesis"], "Q7L5A8": ["Sphingolipid de novo biosynthesis"], "Q7L5L3": ["Glycerophospholipid catabolism"], "Q7L5N1": ["DNA Damage Recognition in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Cargo recognition for clathrin-mediated endocytosis", "Neddylation"], "Q7L5N7": ["Acyl chain remodelling of PC"], "Q7L5Y6": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q7L7L0": ["HDACs deacetylate histones", "HATs acetylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "UCH proteinases", "Ub-specific processing proteases", "Metalloprotease DUBs"], "Q7L7X3": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "Q7L804": ["Vasopressin regulates renal water homeostasis via Aquaporins"], "Q7L8W6": ["Synthesis of diphthamide-EEF2"], "Q7L945": ["Generic Transcription Pathway"], "Q7L9L4": ["Signaling by Hippo"], "Q7LBC6": ["HDMs demethylate histones"], "Q7LBE3": ["Multifunctional anion exchangers"], "Q7LDG7": ["Effects of PIP2 hydrolysis", "FCERI mediated NF-kB activation", "Integrin alphaIIb beta3 signaling", "Rap1 signalling"], "Q7LFL8": ["Estrogen-dependent gene expression"], "Q7LFX5": ["Chondroitin sulfate biosynthesis"], "Q7LG56": ["Interconversion of nucleotide di- and triphosphates", "TP53 Regulates Metabolic Genes"], "Q7LGA3": ["HS-GAG biosynthesis"], "Q7LGC8": ["Chondroitin sulfate biosynthesis", "Defective CHST3 causes SEDCJD"], "Q7RTN6": ["Energy dependent regulation of mTOR by LKB1-AMPK"], "Q7RTP0": ["Miscellaneous transport and binding events"], "Q7RTR2": ["IRF3-mediated induction of type I IFN"], "Q7RTR8": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "Q7RTS3": ["Regulation of gene expression in early pancreatic precursor cells"], "Q7RTS7": ["Keratinization", "Formation of the cornified envelope"], "Q7RTT9": ["Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"], "Q7RTV0": ["mRNA Splicing - Major Pathway"], "Q7RTV2": ["Glutathione conjugation"], "Q7RTW8": ["Post-translational modification: synthesis of GPI-anchored proteins"], "Q7RTX0": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "Q7RTX1": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "Q7RTX7": ["Sperm Motility And Taxes"], "Q7RTY9": ["Post-translational modification: synthesis of GPI-anchored proteins"], "Q7RTZ2": ["Ub-specific processing proteases"], "Q7Z2D5": ["Lysosphingolipid and LPA receptors"], "Q7Z2F6": ["Generic Transcription Pathway"], "Q7Z2H8": ["Amino acid transport across the plasma membrane", "Proton-coupled neutral amino acid transporters"], "Q7Z2K8": ["MECP2 regulates neuronal receptors and channels"], "Q7Z2W4": ["Signaling by BRAF and RAF fusions"], "Q7Z2W7": ["TRP channels"], "Q7Z2W9": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q7Z340": ["Generic Transcription Pathway"], "Q7Z392": ["RAB GEFs exchange GTP for GDP on RABs"], "Q7Z398": ["Generic Transcription Pathway"], "Q7Z3B1": ["Post-translational modification: synthesis of GPI-anchored proteins"], "Q7Z3B3": ["HATs acetylate histones"], "Q7Z3B4": ["ISG15 antiviral mechanism", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "tRNA processing in the nucleus"], "Q7Z3C6": ["Macroautophagy"], "Q7Z3J2": ["Neutrophil degranulation"], "Q7Z3S7": ["Phase 0 - rapid depolarisation", "Phase 2 - plateau phase"], "Q7Z3T1": ["Olfactory Signaling Pathway"], "Q7Z3T8": ["Signaling by BMP"], "Q7Z3V4": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q7Z3V5": ["Generic Transcription Pathway"], "Q7Z3Y7": ["Keratinization", "Formation of the cornified envelope"], "Q7Z3Y8": ["Keratinization", "Formation of the cornified envelope"], "Q7Z3Y9": ["Keratinization", "Formation of the cornified envelope"], "Q7Z3Z0": ["Keratinization", "Formation of the cornified envelope"], "Q7Z3Z4": ["PIWI-interacting RNA (piRNA) biogenesis"], "Q7Z401": ["RAB GEFs exchange GTP for GDP on RABs"], "Q7Z403": ["Neutrophil degranulation"], "Q7Z406": ["EPHA-mediated growth cone collapse", "Sema4D induced cell migration and growth-cone collapse", "RHO GTPases activate PKNs", "RHO GTPases activate CIT", "RHO GTPases Activate ROCKs", "RHO GTPases activate PAKs", "RHO GTPases activate PAKs"], "Q7Z412": ["Peroxisomal protein import", "Peroxisomal protein import"], "Q7Z418": ["TWIK-related spinal cord K+ channel (TRESK)", "Phase 4 - resting membrane potential"], "Q7Z419": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q7Z434": ["DDX58/IFIH1-mediated induction of interferon-alpha/beta", "Ovarian tumor domain proteases", "TRAF3-dependent IRF activation pathway", "TRAF6 mediated IRF7 activation", "TRAF6 mediated NF-kB activation", "TRAF6 mediated NF-kB activation", "NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10", "Negative regulators of DDX58/IFIH1 signaling", "Negative regulators of DDX58/IFIH1 signaling"], "Q7Z449": ["Miscellaneous substrates", "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)", "Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56)"], "Q7Z460": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Role of ABL in ROBO-SLIT signaling", "Anchoring of the basal body to the plasma membrane", "RHO GTPases Activate Formins", "Mitotic Prometaphase", "AURKA Activation by TPX2"], "Q7Z494": ["Trafficking of myristoylated proteins to the cilium"], "Q7Z4F1": ["Retinoid metabolism and transport"], "Q7Z4G1": ["Neddylation"], "Q7Z4G4": ["tRNA modification in the nucleus and cytosol"], "Q7Z4H4": ["G alpha (s) signalling events", "Calcitonin-like ligand receptors"], "Q7Z4H7": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "Q7Z4I7": ["Cell-extracellular matrix interactions"], "Q7Z4K8": ["Interferon gamma signaling"], "Q7Z4L5": ["Hedgehog 'off' state", "Intraflagellar transport"], "Q7Z4N2": ["TRP channels"], "Q7Z4N8": ["Collagen biosynthesis and modifying enzymes"], "Q7Z4R8": ["Neutrophil degranulation"], "Q7Z4S6": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "Q7Z4T8": ["O-linked glycosylation of mucins"], "Q7Z4W1": ["Formation of xylulose-5-phosphate", "Essential pentosuria"], "Q7Z4W3": ["Keratinization"], "Q7Z553": ["Post-translational modification: synthesis of GPI-anchored proteins"], "Q7Z569": ["RAF activation", "Negative regulation of MAPK pathway", "Signaling by moderate kinase activity BRAF mutants", "Signaling by RAS mutants", "Paradoxical activation of RAF signaling by kinase inactive BRAF"], "Q7Z5G4": ["Neutrophil degranulation"], "Q7Z5H3": ["Rho GTPase cycle"], "Q7Z5J4": ["Circadian Clock"], "Q7Z5K2": ["Separation of Sister Chromatids", "Establishment of Sister Chromatid Cohesion", "Cohesin Loading onto Chromatin", "Resolution of Sister Chromatid Cohesion"], "Q7Z5N4": ["SDK interactions"], "Q7Z5P4": ["Lipid particle organization"], "Q7Z5P9": ["Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)", "Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)", "Defective GALNT12 causes colorectal cancer 1 (CRCS1)", "Dectin-2 family", "O-linked glycosylation of mucins", "Termination of O-glycan biosynthesis"], "Q7Z5Q5": ["Fanconi Anemia Pathway"], "Q7Z5R6": ["Integrin alphaIIb beta3 signaling", "GRB2:SOS provides linkage to MAPK signaling for Integrins ", "p130Cas linkage to MAPK signaling for integrins", "MAP2K and MAPK activation", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF"], "Q7Z5W3": ["MicroRNA (miRNA) biogenesis"], "Q7Z624": ["Inactivation, recovery and regulation of the phototransduction cascade", "Protein methylation"], "Q7Z628": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "Q7Z698": ["Regulation of RAS by GAPs", "FGFRL1 modulation of FGFR1 signaling", "Signaling by RAS mutants"], "Q7Z699": ["Regulation of RAS by GAPs", "FGFRL1 modulation of FGFR1 signaling", "Signaling by RAS mutants"], "Q7Z6A9": ["Costimulation by the CD28 family", "Costimulation by the CD28 family"], "Q7Z6B7": ["Rho GTPase cycle", "Inactivation of CDC42 and RAC1"], "Q7Z6E9": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q7Z6I6": ["Rho GTPase cycle"], "Q7Z6J0": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q7Z6J4": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "Q7Z6J8": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q7Z6J9": ["tRNA processing in the nucleus"], "Q7Z6M1": ["Retrograde transport at the Trans-Golgi-Network"], "Q7Z6M4": ["rRNA modification in the mitochondrion"], "Q7Z6P3": ["Neutrophil degranulation", "RAB geranylgeranylation"], "Q7Z6R9": ["Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "Activation of the TFAP2 (AP-2) family of transcription factors"], "Q7Z6V5": ["tRNA modification in the nucleus and cytosol"], "Q7Z6Z6": ["Triglyceride catabolism"], "Q7Z6Z7": ["Neutrophil degranulation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q7Z794": ["Keratinization", "Formation of the cornified envelope"], "Q7Z7A1": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "Q7Z7A1-3": ["Signaling by cytosolic FGFR1 fusion mutants", "Signaling by FGFR1 in disease"], "Q7Z7A3": ["tRNA modification in the nucleus and cytosol"], "Q7Z7B1": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "Q7Z7B7": ["Beta defensins", "Defensins"], "Q7Z7B8": ["Beta defensins", "Defensins"], "Q7Z7C8": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes"], "Q7Z7E8": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q7Z7F7": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q7Z7H8": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q7Z7K2": ["Transcriptional regulation of white adipocyte differentiation"], "Q7Z7M8": ["O-linked glycosylation of mucins"], "Q7Z7M9": ["O-linked glycosylation of mucins"], "Q7Z7N9": ["Neutrophil degranulation"], "Q86SE9": ["RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "Q86SF2": ["O-linked glycosylation of mucins"], "Q86SG5": ["Metal sequestration by antimicrobial proteins"], "Q86SJ6": ["Keratinization", "Formation of the cornified envelope"], "Q86SK9": ["Fatty acyl-CoA biosynthesis"], "Q86SQ7": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "Q86SQ9": ["Synthesis of Dolichyl-phosphate", "Defective DHDDS causes retinitis pigmentosa 59"], "Q86SR1": ["O-linked glycosylation of mucins"], "Q86SS6": ["Neurexins and neuroligins", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "Q86SX6": ["Mitochondrial iron-sulfur cluster biogenesis"], "Q86SZ2": ["COPII-mediated vesicle transport", "RAB GEFs exchange GTP for GDP on RABs"], "Q86T03": ["PI5P Regulates TP53 Acetylation", "Synthesis of PIPs in the nucleus"], "Q86T29": ["Generic Transcription Pathway"], "Q86T82": ["Ub-specific processing proteases"], "Q86TB9": ["mRNA decay by 5' to 3' exoribonuclease", "mRNA decay by 5' to 3' exoribonuclease"], "Q86TH1": ["Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "Q86TI0": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Translocation of SLC2A4 (GLUT4) to the plasma membrane"], "Q86TJ2": ["HATs acetylate histones", "Ub-specific processing proteases"], "Q86TJ5": ["Generic Transcription Pathway"], "Q86TL0": ["Macroautophagy"], "Q86TM6": ["XBP1(S) activates chaperone genes", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "ER Quality Control Compartment (ERQC)"], "Q86TS9": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q86TU7": ["PKMTs methylate histone lysines"], "Q86TX2": ["Mitochondrial Fatty Acid Beta-Oxidation"], "Q86U10": ["Amino acid synthesis and interconversion (transamination)"], "Q86U28": ["Mitochondrial iron-sulfur cluster biogenesis"], "Q86U42": ["Cleavage of Growing Transcript in the Termination Region ", "Inhibition of Host mRNA Processing and RNA Silencing", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "Q86U44": ["Processing of Capped Intron-Containing Pre-mRNA"], "Q86U70": ["RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of expression of SLITs and ROBOs"], "Q86U86": ["RMTs methylate histone arginines", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "Q86UD5": ["Stimuli-sensing channels"], "Q86UE3": ["Generic Transcription Pathway"], "Q86UE6": ["Neurexins and neuroligins"], "Q86UF1": ["Amyloid fiber formation"], "Q86UK0": ["ABC transporters in lipid homeostasis", "Defective ABCA12 causes autosomal recessive congenital ichthyosis type 4B"], "Q86UK5": ["Hedgehog 'on' state", "Activation of SMO", "Activation of SMO"], "Q86UL3": ["Synthesis of PA"], "Q86UL8": ["Nephrin family interactions"], "Q86UN2": ["Post-translational modification: synthesis of GPI-anchored proteins"], "Q86UN3": ["Post-translational modification: synthesis of GPI-anchored proteins"], "Q86UP0": ["Adherens junctions interactions"], "Q86UP2": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "RHO GTPases activate KTN1", "Post-translational protein phosphorylation"], "Q86UQ0": ["Generic Transcription Pathway"], "Q86UQ4": ["Neutrophil degranulation"], "Q86UR1": ["RHO GTPases Activate NADPH Oxidases"], "Q86UR5": ["Serotonin Neurotransmitter Release Cycle", "Norepinephrine Neurotransmitter Release Cycle", "Glutamate Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle", "Acetylcholine Neurotransmitter Release Cycle", "GABA synthesis, release, reuptake and degradation"], "Q86US8": ["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "Q86UT5": ["Intestinal infectious diseases"], "Q86UT6": ["DDX58/IFIH1-mediated induction of interferon-alpha/beta", "Negative regulators of DDX58/IFIH1 signaling"], "Q86UU0": ["Formation of the beta-catenin:TCF transactivating complex", "Deactivation of the beta-catenin transactivating complex"], "Q86UV5": ["Ub-specific processing proteases"], "Q86UW9": ["Activated NOTCH1 Transmits Signal to the Nucleus", "Activated NOTCH1 Transmits Signal to the Nucleus"], "Q86UX7": ["Platelet degranulation "], "Q86V21": ["Synthesis of Ketone Bodies"], "Q86V24": ["AMPK inhibits chREBP transcriptional activation activity", "AMPK inhibits chREBP transcriptional activation activity"], "Q86V71": ["Generic Transcription Pathway"], "Q86V81": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing"], "Q86V97": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q86VB7": ["Scavenging of heme from plasma"], "Q86VD9": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "Q86VE9": ["Serine biosynthesis"], "Q86VF5": ["Triglyceride biosynthesis"], "Q86VH2": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "Q86VH4": ["Neurexins and neuroligins"], "Q86VH5": ["Neurexins and neuroligins"], "Q86VI3": ["RHO GTPases activate IQGAPs"], "Q86VL8": ["Transport of bile salts and organic acids, metal ions and amine compounds"], "Q86VN1": ["Endosomal Sorting Complex Required For Transport (ESCRT)"], "Q86VP1": ["Regulation of TNFR1 signaling", "Negative regulators of DDX58/IFIH1 signaling"], "Q86VP6": ["Neutrophil degranulation", "Neddylation", "Iron uptake and transport"], "Q86VW1": ["Organic cation transport"], "Q86VW2": ["G alpha (q) signalling events"], "Q86VX2": ["Neddylation"], "Q86VX9": ["RAB GEFs exchange GTP for GDP on RABs"], "Q86VZ5": ["Sphingolipid de novo biosynthesis"], "Q86W42": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA 3'-end processing"], "Q86W47": ["Ca2+ activated K+ channels", "cGMP effects"], "Q86W56": ["POLB-Dependent Long Patch Base Excision Repair"], "Q86W92": ["Receptor-type tyrosine-protein phosphatases"], "Q86WA6": ["Phase I - Functionalization of compounds"], "Q86WA8": ["Association of TriC/CCT with target proteins during biosynthesis", "Peroxisomal protein import", "Peroxisomal protein import"], "Q86WA9": ["Multifunctional anion exchangers"], "Q86WC4": ["Stimuli-sensing channels"], "Q86WG5": ["Synthesis of PIPs at the plasma membrane", "RAB GEFs exchange GTP for GDP on RABs"], "Q86WI3": ["DDX58/IFIH1-mediated induction of interferon-alpha/beta", "Negative regulators of DDX58/IFIH1 signaling"], "Q86WJ1": ["Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER"], "Q86WQ0": ["Nuclear Receptor transcription pathway"], "Q86WT1": ["Intraflagellar transport", "Intraflagellar transport"], "Q86WT6": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q86WU2": ["Mitochondrial protein import", "Mitochondrial protein import"], "Q86WV6": ["STING mediated induction of host immune responses", "Regulation of innate immune responses to cytosolic DNA", "STAT6-mediated induction of chemokines", "IRF3-mediated induction of type I IFN", "Neutrophil degranulation"], "Q86WX3": ["Regulation of HSF1-mediated heat shock response"], "Q86WZ6": ["Generic Transcription Pathway"], "Q86X10": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane"], "Q86X29": ["LDL clearance", "VLDL clearance"], "Q86X52": ["Chondroitin sulfate biosynthesis", "Defective CHSY1 causes TPBS"], "Q86X55": ["RORA activates gene expression", "BMAL1:CLOCK,NPAS2 activates circadian gene expression", "PPARA activates gene expression", "PPARA activates gene expression", "Transcriptional activation of mitochondrial biogenesis", "Activation of gene expression by SREBF (SREBP)", "RMTs methylate histone arginines", "Transcriptional regulation of white adipocyte differentiation", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)", "Circadian Clock", "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "Estrogen-dependent gene expression"], "Q86X67": ["Interconversion of nucleotide di- and triphosphates"], "Q86X83": ["Neddylation"], "Q86XD5": ["Signaling by BRAF and RAF fusions"], "Q86XE3": ["Mitochondrial calcium ion transport", "Processing of SMDT1"], "Q86XE5": ["Glyoxylate metabolism and glycine degradation"], "Q86XF0": ["Metabolism of folate and pterines"], "Q86XI2": ["Condensation of Prophase Chromosomes"], "Q86XK2": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q86XL3": ["Initiation of Nuclear Envelope Reformation"], "Q86XM0": ["Sperm Motility And Taxes"], "Q86XN6": ["Generic Transcription Pathway"], "Q86XP0": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PS", "Acyl chain remodelling of PE", "Acyl chain remodelling of PI", "Acyl chain remodelling of PG", "Hydrolysis of LPC", "Synthesis of PA"], "Q86XP1": ["Effects of PIP2 hydrolysis"], "Q86XP3": ["mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "Q86XQ3": ["Sperm Motility And Taxes"], "Q86XR7": ["Caspase activation via Death Receptors in the presence of ligand", "Toll Like Receptor 4 (TLR4) Cascade", "MyD88-independent TLR4 cascade ", "TRIF-mediated programmed cell death", "Neutrophil degranulation", "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon", "IKK complex recruitment mediated by RIP1", "TRAF6-mediated induction of TAK1 complex within TLR4 complex", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"], "Q86XR8": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "Q86XS8": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q86XT2": ["Budding and maturation of HIV virion", "Membrane binding and targetting of GAG proteins", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "Q86XT4": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q86XT9": ["TP53 Regulates Transcription of Death Receptors and Ligands"], "Q86XU0": ["Generic Transcription Pathway"], "Q86Y01": ["Activated NOTCH1 Transmits Signal to the Nucleus", "Activated NOTCH1 Transmits Signal to the Nucleus"], "Q86Y07-2": ["Clearance of Nuclear Envelope Membranes from Chromatin", "Initiation of Nuclear Envelope Reformation"], "Q86Y13": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q86Y22": ["Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Integrin cell surface interactions", "Collagen chain trimerization"], "Q86Y25": ["Generic Transcription Pathway"], "Q86Y34": ["Neutrophil degranulation"], "Q86Y38": ["A tetrasaccharide linker sequence is required for GAG synthesis"], "Q86Y39": ["Respiratory electron transport", "Complex I biogenesis"], "Q86Y46": ["Keratinization", "Formation of the cornified envelope"], "Q86Y91": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "Q86Y97": ["PKMTs methylate histone lysines"], "Q86YB8": ["Insulin processing"], "Q86YC2": ["HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange"], "Q86YE8": ["Generic Transcription Pathway"], "Q86YF9": ["Hedgehog 'on' state"], "Q86YH6": ["Ubiquinol biosynthesis"], "Q86YL7": ["GPVI-mediated activation cascade"], "Q86YM7": ["Neurexins and neuroligins", "Neurexins and neuroligins"], "Q86YN1": ["Synthesis of Dolichyl-phosphate"], "Q86YN6": ["PPARA activates gene expression", "Transcriptional activation of mitochondrial biogenesis", "Transcriptional activation of mitochondrial biogenesis", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity"], "Q86YP4": ["HDACs deacetylate histones", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "Regulation of TP53 Activity through Acetylation", "RNA Polymerase I Transcription Initiation", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription"], "Q86YR5": ["G alpha (i) signalling events"], "Q86YS6": ["Retrograde transport at the Trans-Golgi-Network", "RAB geranylgeranylation"], "Q86YS7": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane"], "Q86YT5": ["Sodium-coupled sulphate, di- and tri-carboxylate transporters"], "Q86YT6": ["Activated NOTCH1 Transmits Signal to the Nucleus", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "NOTCH2 Activation and Transmission of Signal to the Nucleus", "NOTCH3 Activation and Transmission of Signal to the Nucleus"], "Q86YT9": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall"], "Q86YV0": ["Regulation of RAS by GAPs", "Signaling by RAS mutants"], "Q86YW0": ["Synthesis of IP3 and IP4 in the cytosol"], "Q86YW5": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "Q86YW7": ["Hormone ligand-binding receptors", "G alpha (s) signalling events"], "Q86YZ3": ["Neutrophil degranulation"], "Q86Z02": ["YAP1- and WWTR1 (TAZ)-stimulated gene expression", "Physiological factors", "Regulation of TP53 Activity through Phosphorylation"], "Q86Z14": ["PI3K Cascade", "PIP3 activates AKT signaling", "betaKlotho-mediated ligand binding", "Constitutive Signaling by Aberrant PI3K in Cancer", "Phospholipase C-mediated cascade; FGFR4", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "PI-3K cascade:FGFR4", "Negative regulation of FGFR4 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "Q8HWS3": ["Regulation of gene expression in beta cells"], "Q8IU54": ["Other interleukin signaling", "Interleukin-20 family signaling"], "Q8IU57": ["Other interleukin signaling", "Interleukin-20 family signaling"], "Q8IU60": ["ATF4 activates genes", "mRNA decay by 5' to 3' exoribonuclease", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "KSRP (KHSRP) binds and destabilizes mRNA"], "Q8IU80": ["Collagen degradation", "Collagen degradation", "Degradation of the extracellular matrix", "Degradation of the extracellular matrix"], "Q8IU89": ["Sphingolipid de novo biosynthesis"], "Q8IUA7": ["ABC transporters in lipid homeostasis"], "Q8IUB9": ["Keratinization"], "Q8IUC0": ["Keratinization"], "Q8IUC1": ["Keratinization"], "Q8IUC2": ["Keratinization"], "Q8IUC4": ["RHO GTPases Activate Rhotekin and Rhophilins", "RHO GTPases Activate Rhotekin and Rhophilins"], "Q8IUC6": ["Caspase activation via Death Receptors in the presence of ligand", "MyD88-independent TLR4 cascade ", "Toll Like Receptor 3 (TLR3) Cascade", "TICAM1, RIP1-mediated IKK complex recruitment ", "RIP-mediated NFkB activation via ZBP1", "TRIF-mediated programmed cell death", "TICAM1 deficiency - HSE", "TRAF3 deficiency - HSE", "TLR3-mediated TICAM1-dependent programmed cell death", "TICAM1-dependent activation of IRF3/IRF7", "TICAM1,TRAF6-dependent induction of TAK1 complex", "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon", "IKK complex recruitment mediated by RIP1", "TRAF6-mediated induction of TAK1 complex within TLR4 complex", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"], "Q8IUC8": ["O-linked glycosylation of mucins"], "Q8IUD6": ["DDX58/IFIH1-mediated induction of interferon-alpha/beta", "Ovarian tumor domain proteases", "TRAF3-dependent IRF activation pathway", "TRAF6 mediated IRF7 activation", "TRAF6 mediated NF-kB activation", "TRAF6 mediated NF-kB activation", "NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10", "Negative regulators of DDX58/IFIH1 signaling", "Negative regulators of DDX58/IFIH1 signaling"], "Q8IUE6": ["HDACs deacetylate histones", "HATs acetylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "UCH proteinases", "Ub-specific processing proteases", "Metalloprotease DUBs"], "Q8IUF8": ["HDMs demethylate histones"], "Q8IUG1": ["Keratinization"], "Q8IUN9": ["Dectin-2 family"], "Q8IUQ0": ["Lysosome Vesicle Biogenesis"], "Q8IUQ4": ["Netrin-1 signaling", "Amyloid fiber formation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q8IUR0": ["COPII-mediated vesicle transport", "RAB GEFs exchange GTP for GDP on RABs"], "Q8IUR6": ["CREB3 factors activate genes"], "Q8IUR7": ["Neutrophil degranulation"], "Q8IUX1": ["Complex I biogenesis"], "Q8IUZ0": ["Carboxyterminal post-translational modifications of tubulin"], "Q8IUZ5": ["Collagen degradation", "Lysine catabolism"], "Q8IV01": ["Neurexins and neuroligins"], "Q8IV04": ["Neutrophil degranulation", "TBC/RABGAPs"], "Q8IV08": ["Synthesis of PG", "Role of phospholipids in phagocytosis"], "Q8IV16": ["Post-translational modification: synthesis of GPI-anchored proteins", "Assembly of active LPL and LIPC lipase complexes", "Chylomicron remodeling", "Retinoid metabolism and transport"], "Q8IV42": ["Selenocysteine synthesis"], "Q8IV48": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "Q8IV53": ["RAB GEFs exchange GTP for GDP on RABs"], "Q8IV61": ["Activation of RAS in B cells", "Activation of RAS in B cells", "RAF/MAP kinase cascade"], "Q8IV63": ["ERKs are inactivated"], "Q8IV77": ["VxPx cargo-targeting to cilium", "VxPx cargo-targeting to cilium"], "Q8IVA1": ["G alpha (i) signalling events"], "Q8IVB4": ["Sodium/Proton exchangers", "Defective SLC9A9 causes autism 16 (AUTS16)"], "Q8IVC4": ["Generic Transcription Pathway"], "Q8IVF5": ["NRAGE signals death through JNK", "Rho GTPase cycle", "PPARA activates gene expression", "G alpha (12/13) signalling events"], "Q8IVF7": ["RHO GTPases Activate Formins"], "Q8IVG9": ["G alpha (q) signalling events", "G alpha (i) signalling events", "Formyl peptide receptors bind formyl peptides and many other ligands"], "Q8IVH4": ["Cobalamin (Cbl, vitamin B12) transport and metabolism", "Defective MMAA causes methylmalonic aciduria type cblA", "Defective MUT causes methylmalonic aciduria mut type", "Propionyl-CoA catabolism"], "Q8IVI9": ["NOSTRIN mediated eNOS trafficking"], "Q8IVJ1": ["Metal ion SLC transporters"], "Q8IVK1": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "Q8IVL5": ["Collagen biosynthesis and modifying enzymes"], "Q8IVL6": ["Collagen biosynthesis and modifying enzymes"], "Q8IVN8": ["Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "Q8IVP5": ["Receptor Mediated Mitophagy"], "Q8IVP9": ["Generic Transcription Pathway"], "Q8IVQ6": ["eNOS activation"], "Q8IVS2": ["Mitochondrial Fatty Acid Beta-Oxidation"], "Q8IVS8": ["Fructose catabolism"], "Q8IVT5": ["RAF activation", "MAP2K and MAPK activation", "Negative regulation of MAPK pathway", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF"], "Q8IVU3": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q8IW35": ["Anchoring of the basal body to the plasma membrane"], "Q8IW41": ["Oxidative Stress Induced Senescence", "MAPK6/MAPK4 signaling", "Regulation of TP53 Activity through Phosphorylation"], "Q8IW45": ["Nicotinamide salvaging"], "Q8IW52": ["Receptor-type tyrosine-protein phosphatases"], "Q8IW93": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "Q8IWA0": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "Q8IWA4": ["Pink/Parkin Mediated Mitophagy", "Factors involved in megakaryocyte development and platelet production"], "Q8IWA5": ["Synthesis of PC", "Transport of bile salts and organic acids, metal ions and amine compounds", "Neutrophil degranulation"], "Q8IWE4": ["Neddylation"], "Q8IWF6": ["RAB GEFs exchange GTP for GDP on RABs"], "Q8IWI9": ["Transcriptional Regulation by E2F6"], "Q8IWJ2": ["Retrograde transport at the Trans-Golgi-Network"], "Q8IWL1": ["Toll Like Receptor 4 (TLR4) Cascade", "Toll Like Receptor TLR1:TLR2 Cascade", "Signal regulatory protein family interactions", "Surfactant metabolism", "Regulation of TLR by endogenous ligand", "Defective SFTPA2 causes idiopathic pulmonary fibrosis (IPF)", "Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5)", "Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)"], "Q8IWL2": ["Toll Like Receptor 4 (TLR4) Cascade", "Toll Like Receptor TLR1:TLR2 Cascade", "Signal regulatory protein family interactions", "Surfactant metabolism", "Regulation of TLR by endogenous ligand", "Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5)", "Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)"], "Q8IWL3": ["Mitochondrial protein import", "Mitochondrial protein import", "Mitochondrial iron-sulfur cluster biogenesis"], "Q8IWT0": ["tRNA processing in the nucleus"], "Q8IWT1": ["Interaction between L1 and Ankyrins", "Phase 0 - rapid depolarisation"], "Q8IWT3": ["Neddylation"], "Q8IWT6": ["Miscellaneous transport and binding events"], "Q8IWU4": ["Insulin processing", "Zinc efflux and compartmentalization by the SLC30 family"], "Q8IWU9": ["Serotonin and melatonin biosynthesis"], "Q8IWV2": ["Post-translational modification: synthesis of GPI-anchored proteins"], "Q8IWV7": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q8IWV8": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q8IWW6": ["Rho GTPase cycle"], "Q8IWW8": ["Interconversion of 2-oxoglutarate and 2-hydroxyglutarate"], "Q8IWX5": ["Sphingolipid de novo biosynthesis"], "Q8IWX8": ["mRNA Splicing - Major Pathway"], "Q8IWY4": ["Degradation of the extracellular matrix"], "Q8IWZ4": ["Interferon gamma signaling"], "Q8IWZ6": ["BBSome-mediated cargo-targeting to cilium"], "Q8IWZ8": ["mRNA Splicing - Major Pathway"], "Q8IX03": ["Signaling by Hippo", "NOTCH3 Intracellular Domain Regulates Transcription"], "Q8IX07": ["RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Factors involved in megakaryocyte development and platelet production"], "Q8IX12": ["mRNA Splicing - Major Pathway"], "Q8IX19": ["Neutrophil degranulation"], "Q8IX30": ["Degradation of the extracellular matrix"], "Q8IXE1": ["Olfactory Signaling Pathway"], "Q8IXF9": ["Passive transport by Aquaporins"], "Q8IXH7": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Abortive elongation of HIV-1 transcript in the absence of Tat", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "RNA Polymerase II Transcription Elongation"], "Q8IXI1": ["Rho GTPase cycle"], "Q8IXI2": ["Rho GTPase cycle", "Ub-specific processing proteases"], "Q8IXJ9": ["UCH proteinases"], "Q8IXK0": ["Oxidative Stress Induced Senescence", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of transcription cofactors", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA methylation proteins", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription"], "Q8IXK2": ["Defective GALNT12 causes colorectal cancer 1 (CRCS1)", "O-linked glycosylation of mucins"], "Q8IXL6": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "Q8IXL7": ["Protein repair"], "Q8IXM3": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q8IXN7": ["Amino acid synthesis and interconversion (transamination)"], "Q8IXQ6": ["Nicotinamide salvaging"], "Q8IXQ9": ["Protein methylation"], "Q8IXW5": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes"], "Q8IXY8": ["mRNA Splicing - Major Pathway"], "Q8IY17": ["Glycerophospholipid catabolism"], "Q8IY18": ["SUMOylation of DNA damage response and repair proteins"], "Q8IY26": ["Cholesterol biosynthesis"], "Q8IY31": ["Intraflagellar transport", "Intraflagellar transport"], "Q8IY34": ["Proton/oligopeptide cotransporters"], "Q8IY37": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "Q8IY57": ["RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Transcriptional Regulation by E2F6"], "Q8IY63": ["Signaling by Hippo"], "Q8IY81": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "Q8IY92": ["Resolution of D-loop Structures through Holliday Junction Intermediates", "Fanconi Anemia Pathway"], "Q8IYB3": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing"], "Q8IYB9": ["Generic Transcription Pathway"], "Q8IYD1": ["Eukaryotic Translation Termination", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "Q8IYD8": ["Fanconi Anemia Pathway"], "Q8IYF1": ["Formation of RNA Pol II elongation complex ", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "RNA Polymerase II Transcription Elongation"], "Q8IYH5": ["HATs acetylate histones"], "Q8IYI6": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Insulin processing", "VxPx cargo-targeting to cilium"], "Q8IYI8": ["Generic Transcription Pathway"], "Q8IYJ0": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "Q8IYJ3": ["TBC/RABGAPs"], "Q8IYK4": ["Collagen biosynthesis and modifying enzymes"], "Q8IYL2": ["tRNA modification in the nucleus and cytosol"], "Q8IYL9": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (q) signalling events"], "Q8IYM9": ["Interferon gamma signaling"], "Q8IYN0": ["Generic Transcription Pathway"], "Q8IYS5": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation"], "Q8IYU2": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q8IYU8": ["Mitochondrial calcium ion transport", "Processing of SMDT1"], "Q8IYV9": ["Sperm:Oocyte Membrane Binding"], "Q8IYW5": ["SUMOylation of DNA damage response and repair proteins", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "G2/M DNA damage checkpoint"], "Q8IYX0": ["Generic Transcription Pathway"], "Q8IZ26": ["Generic Transcription Pathway"], "Q8IZ52": ["Chondroitin sulfate biosynthesis"], "Q8IZC6": ["Collagen biosynthesis and modifying enzymes", "Assembly of collagen fibrils and other multimeric structures", "MET activates PTK2 signaling", "Collagen chain trimerization"], "Q8IZC7": ["Generic Transcription Pathway"], "Q8IZD2": ["PKMTs methylate histone lysines", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"], "Q8IZD4": ["mRNA decay by 5' to 3' exoribonuclease"], "Q8IZD6": ["Organic cation transport"], "Q8IZD9": ["NTRK2 activates RAC1", "NTRK2 activates RAC1", "Factors involved in megakaryocyte development and platelet production"], "Q8IZF0": ["Stimuli-sensing channels"], "Q8IZF2": ["Surfactant metabolism"], "Q8IZH2": ["mRNA decay by 5' to 3' exoribonuclease", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA"], "Q8IZI9": ["Interleukin-20 family signaling"], "Q8IZJ0": ["Interleukin-20 family signaling"], "Q8IZJ1": ["Netrin-1 signaling", "Netrin mediated repulsion signals", "Caspase activation via Dependence Receptors in the absence of ligand"], "Q8IZJ6": ["Threonine catabolism"], "Q8IZK6": ["TRP channels"], "Q8IZL2": ["Pre-NOTCH Transcription and Translation", "Pre-NOTCH Transcription and Translation", "Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "NOTCH1 Intracellular Domain Regulates Transcription", "NOTCH1 Intracellular Domain Regulates Transcription", "NOTCH2 intracellular domain regulates transcription", "NOTCH2 intracellular domain regulates transcription", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "Notch-HLH transcription pathway", "RUNX3 regulates NOTCH signaling", "RUNX3 regulates NOTCH signaling", "NOTCH3 Intracellular Domain Regulates Transcription", "NOTCH3 Intracellular Domain Regulates Transcription", "NOTCH4 Intracellular Domain Regulates Transcription", "NOTCH4 Intracellular Domain Regulates Transcription"], "Q8IZL8": ["Major pathway of rRNA processing in the nucleolus and cytosol", "PTK6 Expression"], "Q8IZM6": ["Rho GTPase cycle"], "Q8IZN7": ["Beta defensins", "Defensins"], "Q8IZP0": ["Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs"], "Q8IZP1": ["TBC/RABGAPs"], "Q8IZP7": ["HS-GAG biosynthesis"], "Q8IZS6": ["Intraflagellar transport"], "Q8IZS8": ["Presynaptic depolarization and calcium channel opening", "Phase 0 - rapid depolarisation", "Phase 2 - plateau phase"], "Q8IZT8": ["HS-GAG biosynthesis"], "Q8IZU3": ["Meiotic synapsis"], "Q8IZU8": ["Dermatan sulfate biosynthesis"], "Q8IZU9": ["Nephrin family interactions"], "Q8IZV5": ["The canonical retinoid cycle in rods (twilight vision)", "RA biosynthesis pathway"], "Q8IZW8": ["MET interacts with TNS proteins"], "Q8IZX4": ["HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "Q8IZY2": ["ABC transporters in lipid homeostasis"], "Q8N0S2": ["Meiotic synapsis"], "Q8N0S6": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Deposition of new CENPA-containing nucleosomes at the centromere", "Mitotic Prometaphase"], "Q8N0U8": ["Metabolism of vitamin K"], "Q8N0V4": ["LGI-ADAM interactions"], "Q8N0W3": ["GDP-fucose biosynthesis"], "Q8N0W4": ["Neurexins and neuroligins", "Neurexins and neuroligins"], "Q8N0Y3": ["Olfactory Signaling Pathway"], "Q8N0Y5": ["Olfactory Signaling Pathway"], "Q8N0Z6": ["Regulation of TP53 Activity through Methylation"], "Q8N103": ["Rho GTPase cycle"], "Q8N104": ["Beta defensins", "Defensins"], "Q8N114": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "Q8N122": ["Macroautophagy", "mTOR signalling", "mTORC1-mediated signalling", "HSF1-dependent transactivation", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Regulation of PTEN gene transcription"], "Q8N126": ["Adherens junctions interactions", "Nectin/Necl trans heterodimerization"], "Q8N127": ["Olfactory Signaling Pathway"], "Q8N130": ["Type II Na+/Pi cotransporters", "Defective SLC34A3 causes Hereditary hypophosphatemic rickets with hypercalciuria (HHRH)"], "Q8N135": ["LGI-ADAM interactions"], "Q8N138": ["Sphingolipid de novo biosynthesis", "Neutrophil degranulation"], "Q8N139": ["ABC transporters in lipid homeostasis", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes"], "Q8N140": ["SUMOylation of DNA damage response and repair proteins"], "Q8N142": ["Purine ribonucleoside monophosphate biosynthesis"], "Q8N144": ["Gap junction assembly"], "Q8N145": ["LGI-ADAM interactions"], "Q8N146": ["Olfactory Signaling Pathway"], "Q8N148": ["Olfactory Signaling Pathway"], "Q8N149": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "Q8N157": ["Anchoring of the basal body to the plasma membrane"], "Q8N158": ["A tetrasaccharide linker sequence is required for GAG synthesis", "HS-GAG biosynthesis", "HS-GAG biosynthesis", "HS-GAG degradation", "Defective B4GALT7 causes EDS, progeroid type", "Defective B3GAT3 causes JDSSDHD", "Defective EXT2 causes exostoses 2", "Defective EXT1 causes exostoses 1, TRPS2 and CHDS", "Defective B3GALT6 causes EDSP2 and SEMDJL1", "Retinoid metabolism and transport"], "Q8N159": ["Urea cycle"], "Q8N162": ["Olfactory Signaling Pathway"], "Q8N163": ["Regulation of HSF1-mediated heat shock response"], "Q8N183": ["Complex I biogenesis"], "Q8N184": ["Generic Transcription Pathway"], "Q8N1B4": ["Retrograde transport at the Trans-Golgi-Network"], "Q8N1E6": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q8N1F7": ["ISG15 antiviral mechanism", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "tRNA processing in the nucleus"], "Q8N1F8": ["Neutrophil degranulation"], "Q8N1I0": ["Factors involved in megakaryocyte development and platelet production"], "Q8N1M1": ["Stimuli-sensing channels"], "Q8N1N4": ["Keratinization", "Formation of the cornified envelope"], "Q8N1Q1": ["Reversible hydration of carbon dioxide"], "Q8N1Q8": ["Mitochondrial Fatty Acid Beta-Oxidation"], "Q8N1W1": ["EPHB-mediated forward signaling"], "Q8N1W2": ["Generic Transcription Pathway"], "Q8N201": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes"], "Q8N257": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "HATs acetylate histones", "HATs acetylate histones", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Ub-specific processing proteases", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "Q8N264": ["Rho GTPase cycle"], "Q8N2A8": ["Synthesis of PG", "Synthesis of PA", "PIWI-interacting RNA (piRNA) biogenesis"], "Q8N2C7": ["Stimuli-sensing channels"], "Q8N2G4": ["Post-translational modification: synthesis of GPI-anchored proteins"], "Q8N2G8": ["Neutrophil degranulation"], "Q8N2H4": ["Retrograde transport at the Trans-Golgi-Network"], "Q8N2H9": ["Interleukin-1 signaling", "IRAK1 recruits IKK complex", "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation"], "Q8N2I2": ["Generic Transcription Pathway"], "Q8N2K0": ["Arachidonate production from DAG"], "Q8N2K1": ["E3 ubiquitin ligases ubiquitinate target proteins", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q8N2K1-1": ["E3 ubiquitin ligases ubiquitinate target proteins"], "Q8N2Q7": ["Neurexins and neuroligins", "Neurexins and neuroligins"], "Q8N2S1": ["Molecules associated with elastic fibres"], "Q8N2W9": ["Vitamin D (calciferol) metabolism", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of transcription factors", "SUMOylation of ubiquitinylation proteins", "SUMOylation of transcription cofactors", "SUMOylation of SUMOylation proteins", "SUMOylation of intracellular receptors", "SUMOylation of intracellular receptors", "SUMOylation of DNA replication proteins", "SUMOylation of immune response proteins", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "G2/M DNA damage checkpoint"], "Q8N2Z9": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Deposition of new CENPA-containing nucleosomes at the centromere", "Fanconi Anemia Pathway", "Mitotic Prometaphase"], "Q8N302": ["Signaling by BRAF and RAF fusions"], "Q8N307": ["Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)", "Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)", "Defective GALNT12 causes colorectal cancer 1 (CRCS1)", "Dectin-2 family", "MET activates RAS signaling", "O-linked glycosylation of mucins", "Termination of O-glycan biosynthesis"], "Q8N335": ["Synthesis of PA"], "Q8N339": ["Metallothioneins bind metals"], "Q8N349": ["Olfactory Signaling Pathway"], "Q8N370": ["Amino acid transport across the plasma membrane"], "Q8N371": ["HDMs demethylate histones"], "Q8N387": ["Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)", "Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)", "Defective GALNT12 causes colorectal cancer 1 (CRCS1)", "Dectin-2 family", "O-linked glycosylation of mucins", "Termination of O-glycan biosynthesis"], "Q8N392": ["Rho GTPase cycle"], "Q8N393": ["Generic Transcription Pathway"], "Q8N3A8": ["Nicotinamide salvaging"], "Q8N3C0": ["ALKBH3 mediated reversal of alkylation damage"], "Q8N3E9": ["Synthesis of IP3 and IP4 in the cytosol"], "Q8N3I7": ["BBSome-mediated cargo-targeting to cilium"], "Q8N3J5": ["Branched-chain amino acid catabolism"], "Q8N3J6": ["Adherens junctions interactions"], "Q8N3J9": ["Generic Transcription Pathway"], "Q8N3R9": ["Tight junction interactions"], "Q8N3T1": ["O-linked glycosylation of mucins"], "Q8N3U4": ["Meiotic synapsis", "Separation of Sister Chromatids", "Establishment of Sister Chromatid Cohesion", "Cohesin Loading onto Chromatin", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA damage response and repair proteins", "Estrogen-dependent gene expression"], "Q8N3Y1": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q8N3Y3": ["O-linked glycosylation"], "Q8N3Y7": ["RA biosynthesis pathway"], "Q8N423": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation"], "Q8N428": ["O-linked glycosylation of mucins"], "Q8N441": ["FGFRL1 modulation of FGFR1 signaling"], "Q8N461": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q8N465": ["Interconversion of 2-oxoglutarate and 2-hydroxyglutarate"], "Q8N474": ["TCF dependent signaling in response to WNT", "Negative regulation of TCF-dependent signaling by WNT ligand antagonists"], "Q8N488": ["RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Transcriptional Regulation by E2F6"], "Q8N4A0": ["O-linked glycosylation of mucins"], "Q8N4C8": ["Oxidative Stress Induced Senescence"], "Q8N4E7": ["Iron uptake and transport"], "Q8N4F0": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Antimicrobial peptides", "Post-translational protein phosphorylation"], "Q8N4H5": ["Mitochondrial protein import", "Pink/Parkin Mediated Mitophagy"], "Q8N4J0": ["Histidine catabolism"], "Q8N4M1": ["Synthesis of PC", "Transport of bile salts and organic acids, metal ions and amine compounds"], "Q8N4N8": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "COPI-dependent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "Kinesins"], "Q8N4P2": ["Intraflagellar transport", "Intraflagellar transport"], "Q8N4Q1": ["Mitochondrial protein import"], "Q8N4T4": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "Q8N4T8": ["Fatty acyl-CoA biosynthesis"], "Q8N4V1": ["Miscellaneous transport and binding events"], "Q8N4Z0": ["RAB geranylgeranylation"], "Q8N587": ["Generic Transcription Pathway"], "Q8N5B7": ["Sphingolipid de novo biosynthesis"], "Q8N5C8": ["NOD1/2 Signaling Pathway", "FCERI mediated NF-kB activation", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "activated TAK1 mediates p38 MAPK activation", "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "TNFR1-induced NFkappaB signaling pathway", "CLEC7A (Dectin-1) signaling", "TICAM1,TRAF6-dependent induction of TAK1 complex", "Interleukin-1 signaling", "IRAK2 mediated activation of TAK1 complex", "TRAF6-mediated induction of TAK1 complex within TLR4 complex", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"], "Q8N5D0": ["Neddylation"], "Q8N5N7": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q8N5P1": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes"], "Q8N5S9": ["CaMK IV-mediated phosphorylation of CREB", "CaMK IV-mediated phosphorylation of CREB", "CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "Activation of RAC1 downstream of NMDARs", "Activation of RAC1 downstream of NMDARs"], "Q8N5V2": ["NRAGE signals death through JNK", "Rho GTPase cycle", "EPHA-mediated growth cone collapse", "EPHA-mediated growth cone collapse", "G alpha (12/13) signalling events"], "Q8N5X7": ["ISG15 antiviral mechanism"], "Q8N5Y2": ["HATs acetylate histones"], "Q8N5Y8": ["Nicotinamide salvaging"], "Q8N5Z0": ["Lysine catabolism", "Tryptophan catabolism"], "Q8N628": ["Olfactory Signaling Pathway"], "Q8N661": ["Acyl chain remodelling of PC"], "Q8N668": ["Neddylation"], "Q8N684": ["Cleavage of Growing Transcript in the Termination Region ", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "Q8N687": ["Beta defensins", "Defensins"], "Q8N688": ["Beta defensins", "Defensins"], "Q8N690": ["Beta defensins", "Defensins"], "Q8N695": ["Nicotinamide salvaging", "Organic anion transporters"], "Q8N697": ["Proton/oligopeptide cotransporters", "Neutrophil degranulation"], "Q8N6C8": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation"], "Q8N6D2": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q8N6F1": ["Tight junction interactions"], "Q8N6G5": ["Chondroitin sulfate biosynthesis"], "Q8N6G6": ["Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "Q8N6H7": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "Q8N6M3": ["Lipid particle organization"], "Q8N6M6": ["Metabolism of Angiotensinogen to Angiotensins"], "Q8N6N7": ["Mitochondrial Fatty Acid Beta-Oxidation"], "Q8N6P7": ["Interleukin-20 family signaling"], "Q8N6Q3": ["Common Pathway of Fibrin Clot Formation", "Cell surface interactions at the vascular wall", "Neutrophil degranulation"], "Q8N6T3": ["XBP1(S) activates chaperone genes", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "Clathrin-mediated endocytosis"], "Q8N6T7": ["Pre-NOTCH Transcription and Translation", "Processing of DNA double-strand break ends"], "Q8N6U8": ["Hedgehog 'off' state", "Hedgehog 'on' state"], "Q8N720": ["Generic Transcription Pathway"], "Q8N726": ["Oxidative Stress Induced Senescence", "Oncogene Induced Senescence", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of transcription factors", "Regulation of TP53 Degradation", "Stabilization of p53", "Regulation of RUNX3 expression and activity"], "Q8N729": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "Q8N7E2": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q8N7H5": ["Formation of RNA Pol II elongation complex ", "RNA Polymerase II Pre-transcription Events", "RNA Polymerase II Transcription Elongation", "E3 ubiquitin ligases ubiquitinate target proteins"], "Q8N7K0": ["Generic Transcription Pathway"], "Q8N7M0": ["Intraflagellar transport"], "Q8N7P3": ["Tight junction interactions"], "Q8N7Q3": ["Generic Transcription Pathway"], "Q8N823": ["Generic Transcription Pathway"], "Q8N841": ["Carboxyterminal post-translational modifications of tubulin"], "Q8N859": ["Generic Transcription Pathway"], "Q8N883": ["Generic Transcription Pathway"], "Q8N884": ["STING mediated induction of host immune responses"], "Q8N8D1": ["mRNA Splicing - Minor Pathway"], "Q8N8J6": ["Generic Transcription Pathway"], "Q8N8N0": ["E3 ubiquitin ligases ubiquitinate target proteins"], "Q8N8N7": ["Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"], "Q8N8Q8": ["TP53 Regulates Metabolic Genes", "Respiratory electron transport"], "Q8N8Q9": ["Miscellaneous transport and binding events"], "Q8N8R3": ["Amino acid transport across the plasma membrane"], "Q8N8S7": ["Generation of second messenger molecules", "Signaling by ROBO receptors", "Signaling by ROBO receptors"], "Q8N8V2": ["Interferon gamma signaling"], "Q8N8Y2": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "Q8N8Z8": ["Generic Transcription Pathway"], "Q8N907": ["Signaling by NODAL", "Regulation of signaling by NODAL"], "Q8N972": ["Generic Transcription Pathway"], "Q8N983": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q8N988": ["Generic Transcription Pathway"], "Q8N9A8": ["Depolymerisation of the Nuclear Lamina"], "Q8N9B5": ["Regulation of TP53 Activity through Methylation"], "Q8N9B8": ["RAF/MAP kinase cascade"], "Q8N9F0": ["Amino acid synthesis and interconversion (transamination)"], "Q8N9F7": ["Glycerophospholipid catabolism"], "Q8N9F8": ["Generic Transcription Pathway"], "Q8N9I0": ["Toxicity of botulinum toxin type B (BoNT/B)", "Neurexins and neuroligins", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "Q8N9K5": ["Generic Transcription Pathway"], "Q8N9L9": ["Beta-oxidation of very long chain fatty acids", "Peroxisomal protein import", "Peroxisomal protein import"], "Q8N9N2": ["ALKBH3 mediated reversal of alkylation damage"], "Q8N9N5": ["Regulation of TP53 Activity through Association with Co-factors"], "Q8N9R8": ["RHO GTPases Activate Formins"], "Q8N9Z0": ["Generic Transcription Pathway"], "Q8NA29": ["Synthesis of PC"], "Q8NA42": ["Generic Transcription Pathway"], "Q8NAC3": ["Interleukin-17 signaling"], "Q8NAN2": ["Synthesis of PA"], "Q8NAT1": ["O-linked glycosylation"], "Q8NAV1": ["mRNA Splicing - Major Pathway"], "Q8NB16": ["TRP channels", "RIPK1-mediated regulated necrosis"], "Q8NB49": ["Ion transport by P-type ATPases"], "Q8NB78": ["HDMs demethylate histones", "UCH proteinases"], "Q8NB91": ["Fanconi Anemia Pathway"], "Q8NBF2": ["Platelet degranulation "], "Q8NBJ4": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "Q8NBJ5": ["Collagen biosynthesis and modifying enzymes"], "Q8NBJ7": ["Glycosphingolipid metabolism", "The activation of arylsulfatases"], "Q8NBK3": ["Glycosphingolipid metabolism", "The activation of arylsulfatases"], "Q8NBL1": ["Pre-NOTCH Processing in the Endoplasmic Reticulum"], "Q8NBM8": ["Platelet degranulation "], "Q8NBN7": ["RA biosynthesis pathway"], "Q8NBP7": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "VLDLR internalisation and degradation", "Post-translational protein phosphorylation", "LDL clearance"], "Q8NBQ5": ["Estrogen biosynthesis"], "Q8NBQ7": ["Passive transport by Aquaporins"], "Q8NBS9": ["Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis", "Neutrophil degranulation"], "Q8NBT2": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "Q8NBV8": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "Q8NBW4": ["Macroautophagy", "mTOR signalling", "mTORC1-mediated signalling", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Regulation of PTEN gene transcription"], "Q8NBX0": ["Platelet degranulation "], "Q8NBZ0": ["UCH proteinases", "DNA Damage Recognition in GG-NER"], "Q8NC06": ["Peroxisomal lipid metabolism"], "Q8NC26": ["Generic Transcription Pathway"], "Q8NC56": ["Clearance of Nuclear Envelope Membranes from Chromatin", "Initiation of Nuclear Envelope Reformation", "Depolymerisation of the Nuclear Lamina"], "Q8NC69": ["RUNX1 regulates estrogen receptor mediated transcription", "Neddylation", "Estrogen-dependent gene expression", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q8NC96": ["Golgi Associated Vesicle Biogenesis", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "Q8NCC3": ["Hydrolysis of LPC"], "Q8NCD3": ["Deposition of new CENPA-containing nucleosomes at the centromere"], "Q8NCE0": ["tRNA processing in the nucleus"], "Q8NCE2": ["Macroautophagy", "Synthesis of PIPs at the plasma membrane"], "Q8NCG5": ["O-linked glycosylation of mucins"], "Q8NCG7": ["Arachidonate production from DAG"], "Q8NCH0": ["Dermatan sulfate biosynthesis", "Defective CHST14 causes EDS, musculocontractural type"], "Q8NCK3": ["Generic Transcription Pathway"], "Q8NCL4": ["O-linked glycosylation of mucins"], "Q8NCM2": ["Voltage gated Potassium channels"], "Q8NCM8": ["Hedgehog 'off' state", "Intraflagellar transport"], "Q8NCN5": ["Regulation of pyruvate dehydrogenase (PDH) complex"], "Q8NCQ5": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q8NCR0": ["O-linked glycosylation"], "Q8NCS7": ["Synthesis of PC", "Transport of bile salts and organic acids, metal ions and amine compounds"], "Q8NCW0": ["TCF dependent signaling in response to WNT", "Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling"], "Q8NCW5": ["Nicotinamide salvaging"], "Q8NCW6": ["O-linked glycosylation of mucins"], "Q8ND04": ["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "Q8ND25": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q8ND30": ["Receptor-type tyrosine-protein phosphatases"], "Q8NDG6": ["PIWI-interacting RNA (piRNA) biogenesis"], "Q8NDL9": ["Carboxyterminal post-translational modifications of tubulin"], "Q8NDP4": ["Generic Transcription Pathway"], "Q8NDQ6": ["Generic Transcription Pathway"], "Q8NDV1": ["Sialic acid metabolism", "Termination of O-glycan biosynthesis"], "Q8NDV3": ["Meiotic synapsis"], "Q8NDV7": ["Pre-NOTCH Transcription and Translation", "Oxidative Stress Induced Senescence", "Oncogene Induced Senescence", "Ca2+ pathway", "Post-transcriptional silencing by small RNAs", "Transcriptional regulation by small RNAs", "TP53 Regulates Metabolic Genes", "MAPK6/MAPK4 signaling", "Regulation of RUNX1 Expression and Activity", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Regulation of PTEN mRNA translation", "Competing endogenous RNAs (ceRNAs) regulate PTEN translation", "Transcriptional Regulation by MECP2", "Transcriptional Regulation by MECP2", "Estrogen-dependent gene expression", "Regulation of MECP2 expression and activity"], "Q8NDW4": ["Generic Transcription Pathway"], "Q8NDX2": ["Organic anion transporters", "Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25)"], "Q8NDX5": ["Oxidative Stress Induced Senescence", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of transcription cofactors", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA methylation proteins", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription", "Transcriptional Regulation by E2F6"], "Q8NDX6": ["Generic Transcription Pathway"], "Q8NE09": ["G alpha (i) signalling events"], "Q8NE22": ["Regulation of TP53 Activity through Methylation"], "Q8NE62": ["Choline catabolism"], "Q8NE65": ["Generic Transcription Pathway"], "Q8NE71": ["ABC-family proteins mediated transport"], "Q8NE86": ["Mitochondrial calcium ion transport", "Processing of SMDT1"], "Q8NEB5": ["Role of phospholipids in phagocytosis"], "Q8NEB9": ["PI3K Cascade", "Macroautophagy", "Synthesis of PIPs at the Golgi membrane", "Synthesis of PIPs at the early endosome membrane", "Synthesis of PIPs at the late endosome membrane", "Toll Like Receptor 9 (TLR9) Cascade", "RHO GTPases Activate NADPH Oxidases"], "Q8NEC5": ["Sperm Motility And Taxes"], "Q8NEE6": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q8NEG7": ["RAB GEFs exchange GTP for GDP on RABs"], "Q8NEK5": ["Generic Transcription Pathway"], "Q8NEL9": ["Synthesis of PA"], "Q8NEM0": ["Condensation of Prophase Chromosomes"], "Q8NEM1": ["Generic Transcription Pathway"], "Q8NEM7": ["HATs acetylate histones"], "Q8NEM8": ["Carboxyterminal post-translational modifications of tubulin"], "Q8NEP9": ["Generic Transcription Pathway"], "Q8NER1": ["TRP channels"], "Q8NER5": ["Signaling by NODAL", "Regulation of signaling by NODAL", "Signaling by Activin", "Signaling by Activin"], "Q8NES3": ["Pre-NOTCH Processing in Golgi", "Defective LFNG causes SCDO3"], "Q8NES8": ["Beta defensins", "Defensins"], "Q8NET1": ["Beta defensins", "Defensins"], "Q8NET5": ["Neutrophil degranulation"], "Q8NET6": ["Chondroitin sulfate biosynthesis"], "Q8NET8": ["TRP channels"], "Q8NEV9": ["Interleukin-27 signaling", "Interleukin-27 signaling"], "Q8NEW0": ["Insulin processing", "Zinc efflux and compartmentalization by the SLC30 family"], "Q8NEX9": ["The canonical retinoid cycle in rods (twilight vision)"], "Q8NEY4": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "Q8NEZ2": ["Budding and maturation of HIV virion", "Membrane binding and targetting of GAG proteins", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "Q8NEZ3": ["Hedgehog 'off' state", "Intraflagellar transport"], "Q8NEZ4": ["PKMTs methylate histone lysines", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"], "Q8NEZ5": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q8NF37": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PG", "Synthesis of PA", "Synthesis of PC", "Neutrophil degranulation"], "Q8NF50": ["Factors involved in megakaryocyte development and platelet production"], "Q8NF91": ["Meiotic synapsis"], "Q8NFA2": ["RHO GTPases Activate NADPH Oxidases"], "Q8NFD5": ["RMTs methylate histone arginines", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "Q8NFF2": ["Sodium/Calcium exchangers", "Defective SLC24A4 causes hypomineralized amelogenesis imperfecta (AI)"], "Q8NFF5": ["Vitamin B2 (riboflavin) metabolism"], "Q8NFH3": ["ISG15 antiviral mechanism", "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "RHO GTPases Activate Formins", "tRNA processing in the nucleus", "Mitotic Prometaphase"], "Q8NFH4": ["ISG15 antiviral mechanism", "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "RHO GTPases Activate Formins", "tRNA processing in the nucleus", "Mitotic Prometaphase"], "Q8NFH5": ["ISG15 antiviral mechanism", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "tRNA processing in the nucleus"], "Q8NFH8": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "Q8NFI3": ["N-glycan trimming in the ER and Calnexin/Calreticulin cycle"], "Q8NFJ6": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "Q8NFJ9": ["BBSome-mediated cargo-targeting to cilium"], "Q8NFL0": ["Keratan sulfate biosynthesis", "O-linked glycosylation of mucins"], "Q8NFM4": ["Glucagon signaling in metabolic regulation", "PKA activation", "PKA activation in glucagon signalling", "Adenylate cyclase activating pathway", "Adenylate cyclase inhibitory pathway", "Adenylate cyclase inhibitory pathway", "G alpha (s) signalling events", "G alpha (s) signalling events", "G alpha (i) signalling events", "G alpha (z) signalling events", "G alpha (z) signalling events", "Vasopressin regulates renal water homeostasis via Aquaporins", "Hedgehog 'off' state"], "Q8NFM7": ["MAP2K and MAPK activation"], "Q8NFP4": ["Post-translational modification: synthesis of GPI-anchored proteins"], "Q8NFP7": ["Synthesis of pyrophosphates in the cytosol"], "Q8NFQ5": ["Antimicrobial peptides"], "Q8NFR3": ["Sphingolipid de novo biosynthesis"], "Q8NFR9": ["Interleukin-17 signaling"], "Q8NFT2": ["Transferrin endocytosis and recycling"], "Q8NFT8": ["Activated NOTCH1 Transmits Signal to the Nucleus"], "Q8NFU0": ["Stimuli-sensing channels"], "Q8NFU1": ["Stimuli-sensing channels"], "Q8NFU3": ["Sulfide oxidation to sulfate"], "Q8NFU5": ["Synthesis of IPs in the nucleus"], "Q8NFU7": ["TET1,2,3 and TDG demethylate DNA"], "Q8NFW1": ["Collagen biosynthesis and modifying enzymes", "Collagen chain trimerization"], "Q8NFW8": ["Sialic acid metabolism"], "Q8NFW9": ["Insulin processing"], "Q8NFY4": ["Other semaphorin interactions"], "Q8NFY9": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q8NFZ3": ["Neurexins and neuroligins", "Neurexins and neuroligins"], "Q8NFZ4": ["Neurexins and neuroligins", "Neurexins and neuroligins"], "Q8NFZ5": ["MAP3K8 (TPL2)-dependent MAPK1/3 activation", "Ovarian tumor domain proteases"], "Q8NG11": ["Neutrophil degranulation", "Amyloid fiber formation"], "Q8NG27": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q8NG31": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Deposition of new CENPA-containing nucleosomes at the centromere", "Mitotic Prometaphase"], "Q8NG35": ["Beta defensins", "Defensins"], "Q8NG41": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "Q8NG57": ["Formation of RNA Pol II elongation complex ", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "RNA Polymerase II Transcription Elongation"], "Q8NG68": ["Carboxyterminal post-translational modifications of tubulin"], "Q8NG75": ["Olfactory Signaling Pathway"], "Q8NG76": ["Olfactory Signaling Pathway"], "Q8NG77": ["Olfactory Signaling Pathway"], "Q8NG78": ["Olfactory Signaling Pathway"], "Q8NG80": ["Olfactory Signaling Pathway"], "Q8NG81": ["Olfactory Signaling Pathway"], "Q8NG83": ["Olfactory Signaling Pathway"], "Q8NG84": ["Olfactory Signaling Pathway"], "Q8NG85": ["Olfactory Signaling Pathway"], "Q8NG92": ["Olfactory Signaling Pathway"], "Q8NG94": ["Olfactory Signaling Pathway"], "Q8NG95": ["Olfactory Signaling Pathway"], "Q8NG97": ["Olfactory Signaling Pathway"], "Q8NG98": ["Olfactory Signaling Pathway"], "Q8NG99": ["Olfactory Signaling Pathway"], "Q8NGA0": ["Olfactory Signaling Pathway"], "Q8NGA1": ["Olfactory Signaling Pathway"], "Q8NGA2": ["Olfactory Signaling Pathway"], "Q8NGA5": ["Olfactory Signaling Pathway"], "Q8NGA6": ["Olfactory Signaling Pathway"], "Q8NGA8": ["Olfactory Signaling Pathway"], "Q8NGB2": ["Olfactory Signaling Pathway"], "Q8NGB4": ["Olfactory Signaling Pathway"], "Q8NGB6": ["Olfactory Signaling Pathway"], "Q8NGB8": ["Olfactory Signaling Pathway"], "Q8NGB9": ["Olfactory Signaling Pathway"], "Q8NGC0": ["Olfactory Signaling Pathway"], "Q8NGC1": ["Olfactory Signaling Pathway"], "Q8NGC2": ["Olfactory Signaling Pathway"], "Q8NGC3": ["Olfactory Signaling Pathway"], "Q8NGC4": ["Olfactory Signaling Pathway"], "Q8NGC5": ["Olfactory Signaling Pathway"], "Q8NGC6": ["Olfactory Signaling Pathway"], "Q8NGC7": ["Olfactory Signaling Pathway"], "Q8NGC8": ["Olfactory Signaling Pathway"], "Q8NGC9": ["Olfactory Signaling Pathway"], "Q8NGD0": ["Olfactory Signaling Pathway"], "Q8NGD1": ["Olfactory Signaling Pathway"], "Q8NGD2": ["Olfactory Signaling Pathway"], "Q8NGD3": ["Olfactory Signaling Pathway"], "Q8NGD4": ["Olfactory Signaling Pathway"], "Q8NGD5": ["Olfactory Signaling Pathway"], "Q8NGE0": ["Olfactory Signaling Pathway"], "Q8NGE1": ["Olfactory Signaling Pathway"], "Q8NGE2": ["Olfactory Signaling Pathway"], "Q8NGE3": ["Olfactory Signaling Pathway"], "Q8NGE5": ["Olfactory Signaling Pathway"], "Q8NGE7": ["Olfactory Signaling Pathway"], "Q8NGE8": ["Olfactory Signaling Pathway"], "Q8NGE9": ["Olfactory Signaling Pathway"], "Q8NGF0": ["Olfactory Signaling Pathway"], "Q8NGF1": ["Olfactory Signaling Pathway"], "Q8NGF3": ["Olfactory Signaling Pathway"], "Q8NGF4": ["Olfactory Signaling Pathway"], "Q8NGF6": ["Olfactory Signaling Pathway"], "Q8NGF7": ["Olfactory Signaling Pathway"], "Q8NGF8": ["Olfactory Signaling Pathway"], "Q8NGF9": ["Olfactory Signaling Pathway"], "Q8NGG0": ["Olfactory Signaling Pathway"], "Q8NGG1": ["Olfactory Signaling Pathway"], "Q8NGG2": ["Olfactory Signaling Pathway"], "Q8NGG3": ["Olfactory Signaling Pathway"], "Q8NGG4": ["Olfactory Signaling Pathway"], "Q8NGG5": ["Olfactory Signaling Pathway"], "Q8NGG6": ["Olfactory Signaling Pathway"], "Q8NGG7": ["Olfactory Signaling Pathway"], "Q8NGG8": ["Olfactory Signaling Pathway"], "Q8NGH3": ["Olfactory Signaling Pathway"], "Q8NGH5": ["Olfactory Signaling Pathway"], "Q8NGH6": ["Olfactory Signaling Pathway"], "Q8NGH7": ["Olfactory Signaling Pathway"], "Q8NGH8": ["Olfactory Signaling Pathway"], "Q8NGH9": ["Olfactory Signaling Pathway"], "Q8NGI0": ["Olfactory Signaling Pathway"], "Q8NGI1": ["Olfactory Signaling Pathway"], "Q8NGI2": ["Olfactory Signaling Pathway"], "Q8NGI3": ["Olfactory Signaling Pathway"], "Q8NGI4": ["Olfactory Signaling Pathway"], "Q8NGI6": ["Olfactory Signaling Pathway"], "Q8NGI7": ["Olfactory Signaling Pathway"], "Q8NGI8": ["Olfactory Signaling Pathway"], "Q8NGI9": ["Olfactory Signaling Pathway"], "Q8NGJ0": ["Olfactory Signaling Pathway"], "Q8NGJ1": ["Olfactory Signaling Pathway"], "Q8NGJ2": ["Olfactory Signaling Pathway"], "Q8NGJ3": ["Olfactory Signaling Pathway"], "Q8NGJ4": ["Olfactory Signaling Pathway"], "Q8NGJ5": ["Olfactory Signaling Pathway"], "Q8NGJ6": ["Olfactory Signaling Pathway"], "Q8NGJ7": ["Olfactory Signaling Pathway"], "Q8NGJ8": ["Olfactory Signaling Pathway"], "Q8NGJ9": ["Olfactory Signaling Pathway"], "Q8NGK0": ["Olfactory Signaling Pathway"], "Q8NGK1": ["Olfactory Signaling Pathway"], "Q8NGK3": ["Olfactory Signaling Pathway"], "Q8NGK4": ["Olfactory Signaling Pathway"], "Q8NGK5": ["Olfactory Signaling Pathway"], "Q8NGK6": ["Olfactory Signaling Pathway"], "Q8NGK9": ["Olfactory Signaling Pathway"], "Q8NGL0": ["Olfactory Signaling Pathway"], "Q8NGL1": ["Olfactory Signaling Pathway"], "Q8NGL2": ["Olfactory Signaling Pathway"], "Q8NGL3": ["Olfactory Signaling Pathway"], "Q8NGL4": ["Olfactory Signaling Pathway"], "Q8NGL6": ["Olfactory Signaling Pathway"], "Q8NGL7": ["Olfactory Signaling Pathway"], "Q8NGL9": ["Olfactory Signaling Pathway"], "Q8NGM1": ["Olfactory Signaling Pathway"], "Q8NGM8": ["Olfactory Signaling Pathway"], "Q8NGM9": ["Olfactory Signaling Pathway"], "Q8NGN0": ["Olfactory Signaling Pathway"], "Q8NGN1": ["Olfactory Signaling Pathway"], "Q8NGN2": ["Olfactory Signaling Pathway"], "Q8NGN3": ["Olfactory Signaling Pathway"], "Q8NGN4": ["Olfactory Signaling Pathway"], "Q8NGN5": ["Olfactory Signaling Pathway"], "Q8NGN6": ["Olfactory Signaling Pathway"], "Q8NGN7": ["Olfactory Signaling Pathway"], "Q8NGN8": ["Olfactory Signaling Pathway"], "Q8NGP0": ["Olfactory Signaling Pathway"], "Q8NGP2": ["Olfactory Signaling Pathway"], "Q8NGP3": ["Olfactory Signaling Pathway"], "Q8NGP4": ["Olfactory Signaling Pathway"], "Q8NGP6": ["Olfactory Signaling Pathway"], "Q8NGP8": ["Olfactory Signaling Pathway"], "Q8NGP9": ["Olfactory Signaling Pathway"], "Q8NGQ1": ["Olfactory Signaling Pathway"], "Q8NGQ2": ["Olfactory Signaling Pathway"], "Q8NGQ3": ["Olfactory Signaling Pathway"], "Q8NGQ4": ["Olfactory Signaling Pathway"], "Q8NGQ5": ["Olfactory Signaling Pathway"], "Q8NGQ6": ["Olfactory Signaling Pathway"], "Q8NGR1": ["Olfactory Signaling Pathway"], "Q8NGR2": ["Olfactory Signaling Pathway"], "Q8NGR3": ["Olfactory Signaling Pathway"], "Q8NGR4": ["Olfactory Signaling Pathway"], "Q8NGR5": ["Olfactory Signaling Pathway"], "Q8NGR6": ["Olfactory Signaling Pathway"], "Q8NGR8": ["Olfactory Signaling Pathway"], "Q8NGR9": ["Olfactory Signaling Pathway"], "Q8NGS0": ["Olfactory Signaling Pathway"], "Q8NGS1": ["Olfactory Signaling Pathway"], "Q8NGS2": ["Olfactory Signaling Pathway"], "Q8NGS3": ["Olfactory Signaling Pathway"], "Q8NGS4": ["Olfactory Signaling Pathway"], "Q8NGS5": ["Olfactory Signaling Pathway"], "Q8NGS6": ["Olfactory Signaling Pathway"], "Q8NGS7": ["Olfactory Signaling Pathway"], "Q8NGS8": ["Olfactory Signaling Pathway"], "Q8NGS9": ["Olfactory Signaling Pathway"], "Q8NGT0": ["Olfactory Signaling Pathway"], "Q8NGT1": ["Olfactory Signaling Pathway"], "Q8NGT2": ["Olfactory Signaling Pathway"], "Q8NGT5": ["Olfactory Signaling Pathway"], "Q8NGT7": ["Olfactory Signaling Pathway"], "Q8NGT9": ["Olfactory Signaling Pathway"], "Q8NGU1": ["Olfactory Signaling Pathway"], "Q8NGU2": ["Olfactory Signaling Pathway"], "Q8NGU4": ["Olfactory Signaling Pathway"], "Q8NGU9": ["G alpha (s) signalling events"], "Q8NGV0": ["Olfactory Signaling Pathway"], "Q8NGV5": ["Olfactory Signaling Pathway"], "Q8NGV6": ["Olfactory Signaling Pathway"], "Q8NGV7": ["Olfactory Signaling Pathway"], "Q8NGW1": ["Olfactory Signaling Pathway"], "Q8NGW6": ["Olfactory Signaling Pathway"], "Q8NGX0": ["Olfactory Signaling Pathway"], "Q8NGX1": ["Olfactory Signaling Pathway"], "Q8NGX2": ["Olfactory Signaling Pathway"], "Q8NGX3": ["Olfactory Signaling Pathway"], "Q8NGX5": ["Olfactory Signaling Pathway"], "Q8NGX6": ["Olfactory Signaling Pathway"], "Q8NGX8": ["Olfactory Signaling Pathway"], "Q8NGX9": ["Olfactory Signaling Pathway"], "Q8NGY0": ["Olfactory Signaling Pathway"], "Q8NGY1": ["Olfactory Signaling Pathway"], "Q8NGY2": ["Olfactory Signaling Pathway"], "Q8NGY3": ["Olfactory Signaling Pathway"], "Q8NGY5": ["Olfactory Signaling Pathway"], "Q8NGY6": ["Olfactory Signaling Pathway"], "Q8NGY7": ["Olfactory Signaling Pathway"], "Q8NGY9": ["Olfactory Signaling Pathway"], "Q8NGZ0": ["Olfactory Signaling Pathway"], "Q8NGZ2": ["Olfactory Signaling Pathway"], "Q8NGZ3": ["Olfactory Signaling Pathway"], "Q8NGZ4": ["Olfactory Signaling Pathway"], "Q8NGZ5": ["Olfactory Signaling Pathway"], "Q8NGZ6": ["Olfactory Signaling Pathway"], "Q8NGZ9": ["Olfactory Signaling Pathway"], "Q8NH00": ["Olfactory Signaling Pathway"], "Q8NH01": ["Olfactory Signaling Pathway"], "Q8NH02": ["Olfactory Signaling Pathway"], "Q8NH03": ["Olfactory Signaling Pathway"], "Q8NH04": ["Olfactory Signaling Pathway"], "Q8NH05": ["Olfactory Signaling Pathway"], "Q8NH06": ["Olfactory Signaling Pathway"], "Q8NH07": ["Olfactory Signaling Pathway"], "Q8NH08": ["Olfactory Signaling Pathway"], "Q8NH09": ["Olfactory Signaling Pathway"], "Q8NH10": ["Olfactory Signaling Pathway"], "Q8NH16": ["Olfactory Signaling Pathway"], "Q8NH18": ["Olfactory Signaling Pathway"], "Q8NH19": ["Olfactory Signaling Pathway"], "Q8NH21": ["Olfactory Signaling Pathway"], "Q8NH37": ["Olfactory Signaling Pathway"], "Q8NH40": ["Olfactory Signaling Pathway"], "Q8NH41": ["Olfactory Signaling Pathway"], "Q8NH42": ["Olfactory Signaling Pathway"], "Q8NH43": ["Olfactory Signaling Pathway"], "Q8NH48": ["Olfactory Signaling Pathway"], "Q8NH49": ["Olfactory Signaling Pathway"], "Q8NH50": ["Olfactory Signaling Pathway"], "Q8NH51": ["Olfactory Signaling Pathway"], "Q8NH53": ["Olfactory Signaling Pathway"], "Q8NH54": ["Olfactory Signaling Pathway"], "Q8NH55": ["Olfactory Signaling Pathway"], "Q8NH56": ["Olfactory Signaling Pathway"], "Q8NH57": ["Olfactory Signaling Pathway"], "Q8NH59": ["Olfactory Signaling Pathway"], "Q8NH60": ["Olfactory Signaling Pathway"], "Q8NH61": ["Olfactory Signaling Pathway"], "Q8NH63": ["Olfactory Signaling Pathway"], "Q8NH64": ["Olfactory Signaling Pathway"], "Q8NH67": ["Olfactory Signaling Pathway"], "Q8NH69": ["Olfactory Signaling Pathway"], "Q8NH70": ["Olfactory Signaling Pathway"], "Q8NH72": ["Olfactory Signaling Pathway"], "Q8NH73": ["Olfactory Signaling Pathway"], "Q8NH74": ["Olfactory Signaling Pathway"], "Q8NH76": ["Olfactory Signaling Pathway"], "Q8NH79": ["Olfactory Signaling Pathway"], "Q8NH80": ["Olfactory Signaling Pathway"], "Q8NH81": ["Olfactory Signaling Pathway"], "Q8NH83": ["Olfactory Signaling Pathway"], "Q8NH85": ["Olfactory Signaling Pathway"], "Q8NH87": ["Olfactory Signaling Pathway"], "Q8NH89": ["Olfactory Signaling Pathway"], "Q8NH90": ["Olfactory Signaling Pathway"], "Q8NH92": ["Olfactory Signaling Pathway"], "Q8NH93": ["Olfactory Signaling Pathway"], "Q8NH94": ["Olfactory Signaling Pathway"], "Q8NHA4": ["Olfactory Signaling Pathway"], "Q8NHA6": ["Olfactory Signaling Pathway"], "Q8NHA8": ["Olfactory Signaling Pathway"], "Q8NHB1": ["Olfactory Signaling Pathway"], "Q8NHB7": ["Olfactory Signaling Pathway"], "Q8NHB8": ["Olfactory Signaling Pathway"], "Q8NHC4": ["Olfactory Signaling Pathway"], "Q8NHC5": ["Olfactory Signaling Pathway"], "Q8NHC6": ["Olfactory Signaling Pathway"], "Q8NHC7": ["Olfactory Signaling Pathway"], "Q8NHC8": ["Olfactory Signaling Pathway"], "Q8NHE4": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "Q8NHG7": ["Neutrophil degranulation"], "Q8NHG8": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q8NHH1": ["Carboxyterminal post-translational modifications of tubulin"], "Q8NHJ6": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "Q8NHL6": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "Q8NHM5": ["HDMs demethylate histones"], "Q8NHP1": ["Aflatoxin activation and detoxification"], "Q8NHP6": ["Neutrophil degranulation"], "Q8NHQ1": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "Q8NHU3": ["Sphingolipid de novo biosynthesis"], "Q8NHV4": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "Q8NHW3": ["Regulation of gene expression in beta cells"], "Q8NHW4": ["G alpha (i) signalling events"], "Q8NHX9": ["Stimuli-sensing channels"], "Q8NHY0": ["Asparagine N-linked glycosylation"], "Q8NHY2": ["Autodegradation of the E3 ubiquitin ligase COP1", "Neddylation"], "Q8NHY6": ["Generic Transcription Pathway"], "Q8NHZ8": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q8NI17": ["IL-6-type cytokine receptor ligand interactions"], "Q8NI22": ["COPII-mediated vesicle transport", "Cargo concentration in the ER", "Transport to the Golgi and subsequent modification"], "Q8NI27": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA 3'-end processing"], "Q8NI29": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q8NI32": ["Post-translational modification: synthesis of GPI-anchored proteins"], "Q8NI35": ["Tight junction interactions"], "Q8NI36": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "Q8NI77": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "COPI-dependent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "Kinesins", "Kinesins"], "Q8TA94": ["Generic Transcription Pathway"], "Q8TAA3": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q8TAA5": ["Mitochondrial protein import"], "Q8TAC2": ["Josephin domain DUBs"], "Q8TAD4": ["Insulin processing", "Zinc efflux and compartmentalization by the SLC30 family"], "Q8TAE7": ["Voltage gated Potassium channels"], "Q8TAE8": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q8TAF3": ["Recognition of DNA damage by PCNA-containing replication complex", "Ub-specific processing proteases", "Fanconi Anemia Pathway"], "Q8TAF7": ["Generic Transcription Pathway"], "Q8TAG9": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Insulin processing", "VxPx cargo-targeting to cilium"], "Q8TAM1": ["BBSome-mediated cargo-targeting to cilium"], "Q8TAM2": ["BBSome-mediated cargo-targeting to cilium"], "Q8TAP6": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "Q8TAQ2": ["RMTs methylate histone arginines", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "Q8TAQ5": ["Generic Transcription Pathway", "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release"], "Q8TAT2": ["FGFR2b ligand binding and activation"], "Q8TAT6": ["Translesion Synthesis by POLH"], "Q8TAU3": ["Generic Transcription Pathway"], "Q8TAV3": ["Miscellaneous substrates", "Xenobiotics"], "Q8TAV4": ["Stimuli-sensing channels"], "Q8TAW3": ["Generic Transcription Pathway"], "Q8TAX7": ["Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)", "Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)", "Defective GALNT12 causes colorectal cancer 1 (CRCS1)", "Dectin-2 family", "O-linked glycosylation of mucins", "Termination of O-glycan biosynthesis"], "Q8TB24": ["RAB GEFs exchange GTP for GDP on RABs"], "Q8TB37": ["Complex I biogenesis"], "Q8TB40": ["Acyl chain remodelling of PE"], "Q8TB52": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q8TB61": ["Transport and synthesis of PAPS", "Transport of nucleotide sugars"], "Q8TB69": ["Generic Transcription Pathway"], "Q8TB72": ["Neddylation"], "Q8TB92": ["Synthesis of Ketone Bodies"], "Q8TBA6": ["Intra-Golgi traffic"], "Q8TBB1": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q8TBC4": ["Dectin-1 mediated noncanonical NF-kB signaling", "NIK-->noncanonical NF-kB signaling", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q8TBE1": ["COPII-mediated vesicle transport", "Cargo concentration in the ER"], "Q8TBE9": ["Sialic acid metabolism"], "Q8TBF2": ["Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"], "Q8TBF4": ["mRNA Splicing - Minor Pathway"], "Q8TBF5": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "Q8TBG4": ["Synthesis of PE"], "Q8TBJ4": ["Lysosphingolipid and LPA receptors"], "Q8TBK2": ["PKMTs methylate histone lysines"], "Q8TBN0": ["RAB GEFs exchange GTP for GDP on RABs"], "Q8TBP0": ["TBC/RABGAPs"], "Q8TBX8": ["Synthesis of PIPs at the plasma membrane", "PI5P Regulates TP53 Acetylation", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Synthesis of PIPs in the nucleus"], "Q8TBZ3": ["Ub-specific processing proteases"], "Q8TBZ6": ["tRNA modification in the nucleus and cytosol"], "Q8TBZ8": ["Generic Transcription Pathway"], "Q8TC07": ["TBC/RABGAPs"], "Q8TC12": ["The canonical retinoid cycle in rods (twilight vision)", "RA biosynthesis pathway", "Retinoid metabolism and transport"], "Q8TC21": ["Generic Transcription Pathway"], "Q8TC41": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q8TC59": ["PIWI-interacting RNA (piRNA) biogenesis"], "Q8TCB6": ["Olfactory Signaling Pathway"], "Q8TCC3": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q8TCC7": ["Organic anion transport"], "Q8TCD5": ["Pyrimidine catabolism", "Purine catabolism"], "Q8TCG2": ["Synthesis of PIPs at the ER membrane", "Synthesis of PIPs at the plasma membrane", "Synthesis of PIPs at the Golgi membrane", "Synthesis of PIPs at the early endosome membrane"], "Q8TCT0": ["Glycosphingolipid metabolism"], "Q8TCT1": ["Synthesis of PC", "Synthesis of PE"], "Q8TCT7": ["Regulation of TNFR1 signaling"], "Q8TCT8": ["Regulation of TNFR1 signaling"], "Q8TCU4": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "Q8TCU6": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "Q8TCW9": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "Q8TCX1": ["Intraflagellar transport"], "Q8TCX5": ["RHO GTPases Activate Rhotekin and Rhophilins", "RHO GTPases Activate Rhotekin and Rhophilins"], "Q8TCZ2": ["Cell surface interactions at the vascular wall"], "Q8TD07": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "Q8TD16": ["COPI-independent Golgi-to-ER retrograde traffic"], "Q8TD17": ["Generic Transcription Pathway"], "Q8TD19": ["Activation of NIMA Kinases NEK9, NEK6, NEK7", "Nuclear Pore Complex (NPC) Disassembly"], "Q8TD20": ["Cellular hexose transport"], "Q8TD23": ["Generic Transcription Pathway"], "Q8TD30-1": ["Amino acid synthesis and interconversion (transamination)"], "Q8TD43": ["TRP channels"], "Q8TD46": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "Q8TD47": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "Q8TD55": ["Neutrophil degranulation"], "Q8TD84": ["DSCAM interactions"], "Q8TDB6": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q8TDB8": ["Cellular hexose transport"], "Q8TDD2": ["RUNX2 regulates osteoblast differentiation"], "Q8TDD5": ["TRP channels"], "Q8TDE3": ["Antimicrobial peptides"], "Q8TDF6": ["FCERI mediated NF-kB activation", "RAF/MAP kinase cascade"], "Q8TDL5": ["Antimicrobial peptides"], "Q8TDM5": ["Post-translational modification: synthesis of GPI-anchored proteins"], "Q8TDN1": ["Voltage gated Potassium channels"], "Q8TDN2": ["Voltage gated Potassium channels"], "Q8TDN4": ["Cyclin E associated events during G1/S transition ", "Cyclin A:Cdk2-associated events at S phase entry", "Factors involved in megakaryocyte development and platelet production"], "Q8TDN7": ["Sphingolipid de novo biosynthesis"], "Q8TDQ0": ["Interleukin-2 family signaling"], "Q8TDQ1": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "Q8TDQ7": ["Glycolysis"], "Q8TDR0": ["Intraflagellar transport", "Intraflagellar transport"], "Q8TDS4": ["Hydroxycarboxylic acid-binding receptors", "Class A/1 (Rhodopsin-like receptors)", "G alpha (i) signalling events"], "Q8TDS5": ["Eicosanoid ligand-binding receptors", "G alpha (i) signalling events"], "Q8TDU6": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (s) signalling events"], "Q8TDU9": ["G alpha (i) signalling events", "Relaxin receptors"], "Q8TDV5": ["Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)"], "Q8TDW0": ["Miscellaneous transport and binding events"], "Q8TDX5": ["Tryptophan catabolism"], "Q8TDX6": ["Chondroitin sulfate biosynthesis"], "Q8TDX7": ["Activation of NIMA Kinases NEK9, NEK6, NEK7", "Nuclear Pore Complex (NPC) Disassembly"], "Q8TDY2": ["Macroautophagy"], "Q8TDZ2": ["Factors involved in megakaryocyte development and platelet production"], "Q8TE02": ["HATs acetylate histones"], "Q8TE04": ["Coenzyme A biosynthesis"], "Q8TE23": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "Q8TE49": ["Ovarian tumor domain proteases"], "Q8TE54": ["Multifunctional anion exchangers"], "Q8TE56": ["Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "Q8TE57": ["Degradation of the extracellular matrix", "Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "Q8TE58": ["Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "Q8TE59": ["Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "Q8TE60": ["Degradation of the extracellular matrix", "Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "Q8TEA1": ["tRNA modification in the nucleus and cytosol"], "Q8TEB1": ["Neddylation"], "Q8TEB7": ["Ub-specific processing proteases", "Ovarian tumor domain proteases"], "Q8TED0": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "Q8TED1": ["Detoxification of Reactive Oxygen Species"], "Q8TED4-2": ["Gluconeogenesis"], "Q8TEH3": ["RAB GEFs exchange GTP for GDP on RABs"], "Q8TEK3": ["PKMTs methylate histone lysines"], "Q8TEL6": ["TRP channels"], "Q8TEM1": ["ISG15 antiviral mechanism", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "tRNA processing in the nucleus"], "Q8TEP8": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "Q8TEQ6": ["snRNP Assembly"], "Q8TEQ8": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "Q8TER5": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "Q8TES7": ["Anchoring of the basal body to the plasma membrane"], "Q8TEW0": ["TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "Tight junction interactions"], "Q8TEW6": ["RET signaling"], "Q8TEY5": ["CREB3 factors activate genes"], "Q8TEY7": ["Ub-specific processing proteases", "Regulation of expression of SLITs and ROBOs"], "Q8TF09": ["Intraflagellar transport"], "Q8TF20": ["Generic Transcription Pathway"], "Q8TF32": ["Generic Transcription Pathway"], "Q8TF39": ["Generic Transcription Pathway"], "Q8TF45": ["Generic Transcription Pathway"], "Q8TF47": ["Generic Transcription Pathway"], "Q8TF61": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q8TF62": ["Neutrophil degranulation", "Ion transport by P-type ATPases"], "Q8TF71": ["Amino acid transport across the plasma membrane"], "Q8TF74": ["Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs"], "Q8WTQ1": ["Beta defensins", "Defensins"], "Q8WTQ7": ["Inactivation, recovery and regulation of the phototransduction cascade"], "Q8WTR4": ["Glycerophospholipid catabolism"], "Q8WTR7": ["Cleavage of Growing Transcript in the Termination Region ", "SLBP independent Processing of Histone Pre-mRNAs", "Generic Transcription Pathway", "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"], "Q8WTS1": ["Triglyceride catabolism"], "Q8WTS6": ["PKMTs methylate histone lysines"], "Q8WTT0": ["Dectin-2 family", "Neutrophil degranulation"], "Q8WTV0-2": ["Scavenging by Class B Receptors", "HDL clearance"], "Q8WTW3": ["COPI-mediated anterograde transport", "Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network"], "Q8WU03": ["Conjugation of salicylate with glycine", "Conjugation of benzoate with glycine"], "Q8WU17": ["ER Quality Control Compartment (ERQC)"], "Q8WU20": ["PI3K Cascade", "PIP3 activates AKT signaling", "Frs2-mediated activation", "Frs2-mediated activation", "Constitutive Signaling by Aberrant PI3K in Cancer", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "FRS-mediated FGFR2 signaling", "FRS-mediated FGFR3 signaling", "PI-3K cascade:FGFR3", "FRS-mediated FGFR4 signaling", "PI-3K cascade:FGFR4", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "Signaling by FGFR2 in disease", "Signaling by FGFR4 in disease", "Signaling by FGFR1 in disease", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Signaling by FGFR3 fusions in cancer", "Signaling by FGFR3 point mutants in cancer", "RET signaling", "Activated NTRK2 signals through FRS2 and FRS3", "Activated NTRK2 signals through FRS2 and FRS3"], "Q8WU67": ["Synthesis of PC"], "Q8WU68": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing"], "Q8WUA2": ["mRNA Splicing - Major Pathway"], "Q8WUA4": ["RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter"], "Q8WUD1": ["RAB geranylgeranylation"], "Q8WUD6": ["Synthesis of PC"], "Q8WUF5": ["Regulation of TP53 Activity through Association with Co-factors"], "Q8WUG5": ["Iron uptake and transport", "Iron uptake and transport"], "Q8WUI4": ["NOTCH1 Intracellular Domain Regulates Transcription", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "SUMOylation of DNA damage response and repair proteins", "Regulation of PTEN gene transcription"], "Q8WUJ3": ["Hyaluronan biosynthesis and export"], "Q8WUK0": ["Synthesis of PG"], "Q8WUM0": ["ISG15 antiviral mechanism", "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "RHO GTPases Activate Formins", "tRNA processing in the nucleus", "Mitotic Prometaphase"], "Q8WUM4": ["Budding and maturation of HIV virion", "Uptake and function of anthrax toxins"], "Q8WUM9": ["Sodium-coupled phosphate cotransporters"], "Q8WUP2": ["Cell-extracellular matrix interactions"], "Q8WUW1": ["Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs"], "Q8WUX1": ["Amino acid transport across the plasma membrane"], "Q8WUX2": ["Glutathione synthesis and recycling"], "Q8WUX9": ["Budding and maturation of HIV virion", "Macroautophagy", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "Q8WUY9": ["Rho GTPase cycle"], "Q8WV16": ["Neddylation"], "Q8WV22": ["SUMOylation of DNA damage response and repair proteins"], "Q8WV24": ["Interaction between PHLDA1 and AURKA"], "Q8WV28": ["Regulation of signaling by CBL", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "Q8WV37": ["Generic Transcription Pathway"], "Q8WV44": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q8WVC0": ["Formation of RNA Pol II elongation complex ", "Formation of the beta-catenin:TCF transactivating complex", "RNA Polymerase II Pre-transcription Events", "RNA Polymerase II Transcription Elongation", "E3 ubiquitin ligases ubiquitinate target proteins"], "Q8WVD3": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q8WVE0": ["Protein methylation"], "Q8WVF2": ["RUNX2 regulates osteoblast differentiation"], "Q8WVJ9": ["Transcriptional regulation by RUNX2"], "Q8WVK2": ["mRNA Splicing - Major Pathway"], "Q8WVK7": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "Q8WVM0": ["Transcriptional activation of mitochondrial biogenesis", "rRNA modification in the mitochondrion"], "Q8WVM7": ["Meiotic synapsis", "Separation of Sister Chromatids", "Establishment of Sister Chromatid Cohesion", "Cohesin Loading onto Chromatin", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA damage response and repair proteins", "Estrogen-dependent gene expression"], "Q8WVM8": ["COPII-mediated vesicle transport"], "Q8WVN8": ["Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q8WVP5": ["PI Metabolism"], "Q8WVQ1": ["Neutrophil degranulation"], "Q8WVS4": ["Intraflagellar transport"], "Q8WVT3": ["RAB GEFs exchange GTP for GDP on RABs"], "Q8WVV5": ["Butyrophilin (BTN) family interactions"], "Q8WVX9": ["Wax biosynthesis"], "Q8WVZ9": ["Regulation of RAS by GAPs", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q8WW01": ["tRNA processing in the nucleus"], "Q8WW22": ["HSP90 chaperone cycle for steroid hormone receptors (SHR)"], "Q8WW27": ["mRNA Editing: C to U Conversion", "Formation of the Editosome"], "Q8WW35": ["Intraflagellar transport"], "Q8WW38": ["Factors involved in megakaryocyte development and platelet production"], "Q8WW43": ["Nuclear signaling by ERBB4", "Regulated proteolysis of p75NTR", "NRIF signals cell death from the nucleus", "Activated NOTCH1 Transmits Signal to the Nucleus", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "NOTCH2 Activation and Transmission of Signal to the Nucleus", "EPH-ephrin mediated repulsion of cells", "NOTCH3 Activation and Transmission of Signal to the Nucleus", "NOTCH4 Activation and Transmission of Signal to the Nucleus", "Noncanonical activation of NOTCH3", "Amyloid fiber formation"], "Q8WWA0": ["Antimicrobial peptides"], "Q8WWC4": ["Processing of SMDT1"], "Q8WWG1": ["Signaling by ERBB2", "Signaling by ERBB4", "SHC1 events in ERBB2 signaling", "SHC1 events in ERBB2 signaling", "PI3K events in ERBB4 signaling", "SHC1 events in ERBB4 signaling", "Nuclear signaling by ERBB4", "PIP3 activates AKT signaling", "GRB2 events in ERBB2 signaling", "PI3K events in ERBB2 signaling", "Constitutive Signaling by Aberrant PI3K in Cancer", "RAF/MAP kinase cascade", "ERBB2 Regulates Cell Motility", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "ERBB2 Activates PTK6 Signaling", "Downregulation of ERBB2 signaling"], "Q8WWG9": ["Phase 3 - rapid repolarisation", "Phase 2 - plateau phase"], "Q8WWH4": ["PIWI-interacting RNA (piRNA) biogenesis"], "Q8WWI1": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q8WWI5": ["Synthesis of PC", "Transport of bile salts and organic acids, metal ions and amine compounds", "Choline catabolism"], "Q8WWM9": ["eNOS activation", "Intracellular oxygen transport"], "Q8WWN8": ["Rho GTPase cycle"], "Q8WWQ2": ["HS-GAG degradation"], "Q8WWQ8": ["Hyaluronan uptake and degradation", "Scavenging by Class H Receptors"], "Q8WWR8": ["Sialic acid metabolism"], "Q8WWR8-2": ["Glycosphingolipid metabolism"], "Q8WWT9": ["Sodium-coupled sulphate, di- and tri-carboxylate transporters"], "Q8WWV6": ["Cell surface interactions at the vascular wall"], "Q8WWX0": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q8WWX8": ["Inositol transporters"], "Q8WWY3": ["mRNA Splicing - Major Pathway"], "Q8WWY8": ["Synthesis of PA"], "Q8WWZ1": ["Interleukin-38 signaling", "Interleukin-36 pathway"], "Q8WWZ3": ["TNFs bind their physiological receptors"], "Q8WWZ4": ["ABC transporters in lipid homeostasis"], "Q8WWZ7": ["ABC transporters in lipid homeostasis"], "Q8WX39": ["Transport of fatty acids"], "Q8WX92": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Abortive elongation of HIV-1 transcript in the absence of Tat", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "RNA Polymerase II Transcription Elongation", "NTRK3 as a dependence receptor"], "Q8WXA8": ["Neurotransmitter receptors and postsynaptic signal transmission"], "Q8WXB1": ["Protein methylation"], "Q8WXB4": ["Generic Transcription Pathway"], "Q8WXD0": ["G alpha (s) signalling events", "Relaxin receptors"], "Q8WXD2": ["Platelet degranulation ", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "Q8WXD5": ["snRNP Assembly"], "Q8WXE1": ["Activation of ATR in response to replication stress", "HDR through Single Strand Annealing (SSA)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Fanconi Anemia Pathway", "Regulation of TP53 Activity through Phosphorylation", "G2/M DNA damage checkpoint"], "Q8WXE9": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "Q8WXF3": ["G alpha (s) signalling events", "G alpha (i) signalling events", "Relaxin receptors"], "Q8WXG1": ["Interferon alpha/beta signaling"], "Q8WXG6-3": ["Regulation of TNFR1 signaling", "RAB GEFs exchange GTP for GDP on RABs"], "Q8WXG6-5": ["Regulation of TNFR1 signaling"], "Q8WXH0": ["Meiotic synapsis"], "Q8WXH4": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q8WXH5": ["RUNX1 regulates transcription of genes involved in differentiation of keratinocytes"], "Q8WXH6": ["RAB geranylgeranylation"], "Q8WXI2": ["MAP2K and MAPK activation", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF"], "Q8WXI3": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q8WXI4": ["Mitochondrial Fatty Acid Beta-Oxidation"], "Q8WXI7": ["Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)", "Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)", "Defective GALNT12 causes colorectal cancer 1 (CRCS1)", "Dectin-2 family", "O-linked glycosylation of mucins", "Termination of O-glycan biosynthesis"], "Q8WXI8": ["Dectin-2 family", "Neutrophil degranulation"], "Q8WXI9": ["HDACs deacetylate histones", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "Regulation of TP53 Activity through Acetylation", "RNA Polymerase I Transcription Initiation", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription"], "Q8WXJ9": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q8WXK1": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q8WXK3": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q8WXK4": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q8WXS5": ["Trafficking of AMPA receptors", "Phase 0 - rapid depolarisation", "Phase 2 - plateau phase", "LGI-ADAM interactions"], "Q8WXS8": ["Collagen biosynthesis and modifying enzymes", "Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "Q8WXX7": ["RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "Q8WY07": ["Amino acid transport across the plasma membrane"], "Q8WY54": ["Negative regulation of NMDA receptor-mediated neuronal transmission"], "Q8WY64": ["VLDLR internalisation and degradation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q8WYA0": ["Intraflagellar transport", "Intraflagellar transport"], "Q8WYA1": ["BMAL1:CLOCK,NPAS2 activates circadian gene expression"], "Q8WYA6": ["mRNA Splicing - Major Pathway"], "Q8WYB5": ["HATs acetylate histones"], "Q8WYH8": ["HATs acetylate histones", "Regulation of TP53 Activity through Acetylation"], "Q8WYK0": ["Mitochondrial Fatty Acid Beta-Oxidation"], "Q8WYN0": ["Macroautophagy"], "Q8WYP3": ["RAB GEFs exchange GTP for GDP on RABs"], "Q8WYP5": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "Q8WYQ3": ["Mitochondrial protein import"], "Q8WYQ5": ["MicroRNA (miRNA) biogenesis", "Transcriptional Regulation by MECP2"], "Q8WYR1": ["GPVI-mediated activation cascade", "Synthesis of PIPs at the plasma membrane", "G beta:gamma signalling through PI3Kgamma", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)"], "Q8WZ04": ["Enzymatic degradation of dopamine by COMT"], "Q8WZ42": ["Platelet degranulation ", "Striated Muscle Contraction"], "Q8WZ55": ["Stimuli-sensing channels"], "Q8WZ64": ["Rho GTPase cycle"], "Q8WZ73": ["Regulation of TP53 Degradation"], "Q8WZ84": ["Olfactory Signaling Pathway"], "Q8WZ92": ["Olfactory Signaling Pathway"], "Q8WZ94": ["Olfactory Signaling Pathway"], "Q8WZA1": ["Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3", "O-linked glycosylation"], "Q8WZA2": ["Integrin alphaIIb beta3 signaling", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Rap1 signalling", "Regulation of insulin secretion"], "Q8WZA6": ["Olfactory Signaling Pathway"], "Q92185": ["Sialic acid metabolism"], "Q92186": ["Sialic acid metabolism", "NCAM1 interactions", "N-Glycan antennae elongation"], "Q92187": ["Sialic acid metabolism", "NCAM1 interactions"], "Q92466": ["Ub-specific processing proteases", "DNA Damage Recognition in GG-NER", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "TP53 Regulates Transcription of DNA Repair Genes", "Neddylation"], "Q92478": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "Q92481": ["SUMOylation of transcription factors", "Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "Activation of the TFAP2 (AP-2) family of transcription factors", "TFAP2 (AP-2) family regulates transcription of growth factors and their receptors"], "Q92482": ["Vasopressin regulates renal water homeostasis via Aquaporins", "Passive transport by Aquaporins"], "Q92496": ["Regulation of Complement cascade"], "Q92499": ["tRNA processing in the nucleus"], "Q92502": ["Rho GTPase cycle"], "Q92504": ["Zinc influx into cells by the SLC39 gene family"], "Q92506": ["Fatty acyl-CoA biosynthesis"], "Q92520": ["Platelet degranulation "], "Q92521": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "Q92523": ["Import of palmitoyl-CoA into the mitochondrial matrix", "Signaling by Retinoic Acid"], "Q92526": ["Prefoldin mediated transfer of substrate to CCT/TriC", "Formation of tubulin folding intermediates by CCT/TriC", "Folding of actin by CCT/TriC", "Association of TriC/CCT with target proteins during biosynthesis", "Association of TriC/CCT with target proteins during biosynthesis", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "Q92529": ["Signalling to RAS", "Signalling to RAS", "RAF/MAP kinase cascade", "RET signaling"], "Q92530": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q92535": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "Q92536": ["Basigin interactions", "Amino acid transport across the plasma membrane"], "Q92538": ["Clathrin derived vesicle budding", "VxPx cargo-targeting to cilium", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "Q92539": ["Synthesis of PC", "Synthesis of PE", "Depolymerisation of the Nuclear Lamina", "Triglyceride biosynthesis"], "Q92540": ["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "Q92541": ["Formation of RNA Pol II elongation complex ", "RNA Polymerase II Pre-transcription Events", "RNA Polymerase II Transcription Elongation", "E3 ubiquitin ligases ubiquitinate target proteins"], "Q92542": ["Nuclear signaling by ERBB4", "Degradation of the extracellular matrix", "Regulated proteolysis of p75NTR", "NRIF signals cell death from the nucleus", "Activated NOTCH1 Transmits Signal to the Nucleus", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "NOTCH2 Activation and Transmission of Signal to the Nucleus", "EPH-ephrin mediated repulsion of cells", "Neutrophil degranulation", "NOTCH3 Activation and Transmission of Signal to the Nucleus", "NOTCH4 Activation and Transmission of Signal to the Nucleus", "Noncanonical activation of NOTCH3", "Amyloid fiber formation"], "Q92546": ["Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network", "RAB GEFs exchange GTP for GDP on RABs"], "Q92547": ["HDR through Single Strand Annealing (SSA)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Regulation of TP53 Activity through Phosphorylation", "G2/M DNA damage checkpoint"], "Q92551": ["Synthesis of pyrophosphates in the cytosol", "Synthesis of IPs in the nucleus"], "Q92552": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q92556": ["Nef and signal transduction", "Regulation of actin dynamics for phagocytic cup formation", "VEGFA-VEGFR2 Pathway", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases"], "Q92558": ["Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs"], "Q92560": ["UCH proteinases", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"], "Q92562": ["Synthesis of PIPs at the Golgi membrane", "Synthesis of PIPs at the Golgi membrane", "Synthesis of PIPs at the early endosome membrane", "Synthesis of PIPs at the early endosome membrane", "Synthesis of PIPs at the late endosome membrane", "Synthesis of PIPs at the late endosome membrane"], "Q92564": ["Neddylation"], "Q92569": ["GPVI-mediated activation cascade", "PIP3 activates AKT signaling", "Interleukin-7 signaling", "Interleukin-7 signaling", "Signaling by SCF-KIT", "Synthesis of PIPs at the plasma membrane", "Constitutive Signaling by Aberrant PI3K in Cancer", "Costimulation by the CD28 family", "CD28 dependent PI3K/Akt signaling", "G alpha (q) signalling events", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "RET signaling", "Interleukin receptor SHC signaling", "Regulation of signaling by CBL", "Regulation of signaling by CBL"], "Q92570": ["RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"], "Q92570-1": ["Nuclear Receptor transcription pathway"], "Q92570-2": ["Nuclear Receptor transcription pathway"], "Q92572": ["Golgi Associated Vesicle Biogenesis"], "Q92574": ["Macroautophagy", "Inhibition of TSC complex formation by PKB", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "TBC/RABGAPs"], "Q92581": ["Sodium/Proton exchangers", "Defective SLC9A6 causes X-linked, syndromic mental retardation,, Christianson type (MRXSCH)"], "Q92585": ["Pre-NOTCH Transcription and Translation", "Pre-NOTCH Transcription and Translation", "Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "NOTCH1 Intracellular Domain Regulates Transcription", "NOTCH1 Intracellular Domain Regulates Transcription", "NOTCH2 intracellular domain regulates transcription", "NOTCH2 intracellular domain regulates transcription", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "Notch-HLH transcription pathway", "RUNX3 regulates NOTCH signaling", "RUNX3 regulates NOTCH signaling", "NOTCH3 Intracellular Domain Regulates Transcription", "NOTCH3 Intracellular Domain Regulates Transcription", "NOTCH4 Intracellular Domain Regulates Transcription", "NOTCH4 Intracellular Domain Regulates Transcription"], "Q92597": ["TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain"], "Q92598": ["Scavenging by Class F Receptors", "Scavenging by Class F Receptors", "Regulation of HSF1-mediated heat shock response"], "Q92600": ["Deadenylation of mRNA", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "Q92604": ["Acyl chain remodelling of PG"], "Q92608": ["Nef and signal transduction", "Neutrophil degranulation", "Factors involved in megakaryocyte development and platelet production"], "Q92611": ["XBP1(S) activates chaperone genes", "ER Quality Control Compartment (ERQC)"], "Q92613": ["HATs acetylate histones"], "Q92614": ["Signaling by cytosolic FGFR1 fusion mutants", "Signaling by FGFR1 in disease"], "Q92619": ["Rho GTPase cycle", "Neutrophil degranulation"], "Q92620": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing"], "Q92621": ["ISG15 antiviral mechanism", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "tRNA processing in the nucleus"], "Q92626": ["Crosslinking of collagen fibrils"], "Q92630": ["Regulation of TP53 Activity through Phosphorylation"], "Q92633": ["G alpha (q) signalling events", "G alpha (i) signalling events", "Lysosphingolipid and LPA receptors"], "Q92636": ["TNFR1-mediated ceramide production"], "Q92637": ["Cross-presentation of soluble exogenous antigens (endosomes)", "Cross-presentation of soluble exogenous antigens (endosomes)", "Interferon gamma signaling"], "Q92643": ["Attachment of GPI anchor to uPAR"], "Q92664": ["RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 1 Promoter"], "Q92665": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q92667": ["Mitochondrial calcium ion transport", "Factors involved in megakaryocyte development and platelet production"], "Q92670": ["Generic Transcription Pathway"], "Q92673": ["Amyloid fiber formation"], "Q92674": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Deposition of new CENPA-containing nucleosomes at the centromere", "Mitotic Prometaphase"], "Q92681": ["Organic cation transport", "Intestinal hexose absorption"], "Q92685": ["Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "Defective ALG3 causes ALG3-CDG (CDG-1d)"], "Q92686": ["Long-term potentiation", "Long-term potentiation"], "Q92692": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Adherens junctions interactions", "Nectin/Necl trans heterodimerization"], "Q92696": ["TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "RAB geranylgeranylation"], "Q92729": ["Signaling by SCF-KIT"], "Q92730": ["SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "Sema4D mediated inhibition of cell attachment and migration", "Sema4D induced cell migration and growth-cone collapse"], "Q92731": ["PIP3 activates AKT signaling", "Constitutive Signaling by Aberrant PI3K in Cancer", "Nuclear Receptor transcription pathway", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "ESR-mediated signaling"], "Q92733": ["mRNA Splicing - Major Pathway"], "Q92734": ["COPII-mediated vesicle transport"], "Q92736": ["Stimuli-sensing channels", "Ion homeostasis"], "Q92738": ["Retrograde transport at the Trans-Golgi-Network"], "Q92743": ["Degradation of the extracellular matrix"], "Q92747": ["Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "EPHB-mediated forward signaling", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs", "Clathrin-mediated endocytosis"], "Q92748": ["Import of palmitoyl-CoA into the mitochondrial matrix"], "Q92750": ["HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "Q92752": ["ECM proteoglycans"], "Q92753": ["Nuclear Receptor transcription pathway"], "Q92754": ["SUMOylation of transcription factors", "Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "TFAP2 (AP-2) family regulates transcription of other transcription factors", "Activation of the TFAP2 (AP-2) family of transcription factors", "TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "TFAP2 (AP-2) family regulates transcription of cell cycle factors"], "Q92759": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection", "HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Tat-mediated elongation of the HIV-1 transcript", "NoRC negatively regulates rRNA expression", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "mRNA Capping", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase I Transcription Termination", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE"], "Q92764": ["Keratinization", "Formation of the cornified envelope"], "Q92769": ["p75NTR negatively regulates cell cycle via SC1", "NOTCH1 Intracellular Domain Regulates Transcription", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "HDACs deacetylate histones", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "SUMOylation of chromatin organization proteins", "Regulation of TP53 Activity through Acetylation", "RNA Polymerase I Transcription Initiation", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription", "Regulation of MECP2 expression and activity", "MECP2 regulates neuronal receptors and channels", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "Factors involved in megakaryocyte development and platelet production"], "Q92777": ["Serotonin Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle"], "Q92781": ["Retinoid cycle disease events", "The canonical retinoid cycle in rods (twilight vision)", "RA biosynthesis pathway"], "Q92783": ["EGFR downregulation", "Metalloprotease DUBs", "Negative regulation of MET activity", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "InlB-mediated entry of Listeria monocytogenes into host cell", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "Q92793": ["Regulation of gene expression by Hypoxia-inducible Factor", "RORA activates gene expression", "BMAL1:CLOCK,NPAS2 activates circadian gene expression", "Pre-NOTCH Transcription and Translation", "Pre-NOTCH Transcription and Translation", "PPARA activates gene expression", "PPARA activates gene expression", "Formation of the beta-catenin:TCF transactivating complex", "Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "NOTCH1 Intracellular Domain Regulates Transcription", "NOTCH1 Intracellular Domain Regulates Transcription", "Transcriptional activation of mitochondrial biogenesis", "Activation of gene expression by SREBF (SREBP)", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "HATs acetylate histones", "Attenuation phase", "Notch-HLH transcription pathway", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation", "SUMOylation of transcription cofactors", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)", "Circadian Clock", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "CD209 (DC-SIGN) signaling", "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "Activation of the TFAP2 (AP-2) family of transcription factors", "RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "RUNX3 regulates NOTCH signaling", "RUNX3 regulates NOTCH signaling", "NOTCH3 Intracellular Domain Regulates Transcription", "NOTCH3 Intracellular Domain Regulates Transcription", "NOTCH4 Intracellular Domain Regulates Transcription", "Estrogen-dependent gene expression", "TRAF3-dependent IRF activation pathway", "TRAF6 mediated IRF7 activation", "FOXO-mediated transcription of cell death genes", "Regulation of FOXO transcriptional activity by acetylation", "Regulation of FOXO transcriptional activity by acetylation"], "Q92794": ["HATs acetylate histones", "Regulation of TP53 Activity through Acetylation"], "Q92796": ["Unblocking of NMDA receptors, glutamate binding and activation", "Unblocking of NMDA receptors, glutamate binding and activation", "Ras activation upon Ca2+ influx through NMDA receptor", "NrCAM interactions", "Activation of Ca-permeable Kainate Receptor", "RAF/MAP kinase cascade", "Neurexins and neuroligins", "Neurexins and neuroligins", "Synaptic adhesion-like molecules", "Negative regulation of NMDA receptor-mediated neuronal transmission", "Long-term potentiation"], "Q92797": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA Derived from an Intronless Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "Q92804": ["HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "Q92805": ["Retrograde transport at the Trans-Golgi-Network"], "Q92806": ["Activation of G protein gated Potassium channels", "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "Q92813": ["Regulation of thyroid hormone activity"], "Q92817": ["Formation of the cornified envelope"], "Q92819": ["Hyaluronan biosynthesis and export"], "Q92820": ["Neutrophil degranulation"], "Q92823": ["Interaction between L1 and Ankyrins", "NrCAM interactions", "Neurofascin interactions"], "Q92824": ["NGF processing", "Assembly of active LPL and LIPC lipase complexes"], "Q92830": ["Pre-NOTCH Transcription and Translation", "Pre-NOTCH Transcription and Translation", "Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "NOTCH1 Intracellular Domain Regulates Transcription", "NOTCH1 Intracellular Domain Regulates Transcription", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "HATs acetylate histones", "Notch-HLH transcription pathway", "B-WICH complex positively regulates rRNA expression", "Ub-specific processing proteases", "RNA Polymerase I Transcription Initiation", "RUNX3 regulates NOTCH signaling", "RUNX3 regulates NOTCH signaling", "NOTCH3 Intracellular Domain Regulates Transcription", "NOTCH3 Intracellular Domain Regulates Transcription", "NOTCH4 Intracellular Domain Regulates Transcription"], "Q92831": ["Pre-NOTCH Transcription and Translation", "Pre-NOTCH Transcription and Translation", "YAP1- and WWTR1 (TAZ)-stimulated gene expression", "Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "NOTCH1 Intracellular Domain Regulates Transcription", "NOTCH1 Intracellular Domain Regulates Transcription", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "HATs acetylate histones", "Notch-HLH transcription pathway", "B-WICH complex positively regulates rRNA expression", "Physiological factors", "Metalloprotease DUBs", "RNA Polymerase I Transcription Initiation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX3 regulates NOTCH signaling", "RUNX3 regulates NOTCH signaling", "NOTCH3 Intracellular Domain Regulates Transcription", "NOTCH3 Intracellular Domain Regulates Transcription", "NOTCH4 Intracellular Domain Regulates Transcription", "Estrogen-dependent gene expression", "Regulation of FOXO transcriptional activity by acetylation"], "Q92833": ["PRC2 methylates histones and DNA"], "Q92835": ["Synthesis of PIPs at the plasma membrane", "Synthesis of IP3 and IP4 in the cytosol", "Downstream TCR signaling", "PECAM1 interactions", "Interleukin receptor SHC signaling"], "Q92837": ["Beta-catenin phosphorylation cascade", "Disassembly of the destruction complex and recruitment of AXIN to the membrane"], "Q92838": ["TNFs bind their physiological receptors"], "Q92838-3": ["TNFs bind their physiological receptors"], "Q92839": ["Hyaluronan biosynthesis and export"], "Q92841": ["SUMOylation of transcription cofactors"], "Q92844": ["TICAM1-dependent activation of IRF3/IRF7", "TRAF6 mediated IRF7 activation", "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon"], "Q92845": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "MHC class II antigen presentation", "Intraflagellar transport", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins", "Kinesins"], "Q92847": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "Q92851": ["TP53 Regulates Transcription of Caspase Activators and Caspases", "FasL/ CD95L signaling", "TRAIL signaling", "NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10"], "Q92854": ["Sema4D mediated inhibition of cell attachment and migration", "Sema4D induced cell migration and growth-cone collapse", "Other semaphorin interactions"], "Q92859": ["Netrin-1 signaling", "CDO in myogenesis"], "Q92871": ["Synthesis of GDP-mannose"], "Q92878": ["DNA Damage/Telomere Stress Induced Senescence", "HDR through Single Strand Annealing (SSA)", "HDR through MMEJ (alt-NHEJ)", "HDR through Homologous Recombination (HRR)", "Sensing of DNA Double Strand Breaks", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Nonhomologous End-Joining (NHEJ)", "Homologous DNA Pairing and Strand Exchange", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Regulation of TP53 Activity through Phosphorylation", "G2/M DNA damage checkpoint", "Meiotic recombination"], "Q92882": ["Neutrophil degranulation"], "Q92887": ["ABC-family proteins mediated transport", "Defective ABCC2 causes Dubin-Johnson syndrome"], "Q92888": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "Q92889": ["HDR through Single Strand Annealing (SSA)", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Fanconi Anemia Pathway"], "Q92890": ["Translesion Synthesis by POLH", "Ub-specific processing proteases"], "Q92896": ["Cell surface interactions at the vascular wall"], "Q92900": ["Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "Q92901": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "Q92902": ["RAB GEFs exchange GTP for GDP on RABs"], "Q92903": ["Synthesis of PI"], "Q92905": ["DNA Damage Recognition in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Cargo recognition for clathrin-mediated endocytosis", "Neddylation"], "Q92908": ["Surfactant metabolism", "Factors involved in megakaryocyte development and platelet production"], "Q92911": ["Thyroxine biosynthesis", "Organic anion transporters", "Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1)"], "Q92913": ["Phase 0 - rapid depolarisation"], "Q92914": ["Phase 0 - rapid depolarisation"], "Q92915": ["Phase 0 - rapid depolarisation"], "Q92917": ["mRNA Splicing - Major Pathway"], "Q92922": ["RMTs methylate histone arginines", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "Q92925": ["RMTs methylate histone arginines", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "Q92930": ["TBC/RABGAPs", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "Q92932": ["Neutrophil degranulation"], "Q92934": ["Activation of BAD and translocation to mitochondria ", "Activation of BAD and translocation to mitochondria ", "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "NRAGE signals death through JNK", "AKT phosphorylates targets in the cytosol", "Constitutive Signaling by AKT1 E17K in Cancer"], "Q92935": ["XBP1(S) activates chaperone genes"], "Q92945": ["ATF4 activates genes", "KSRP (KHSRP) binds and destabilizes mRNA", "KSRP (KHSRP) binds and destabilizes mRNA"], "Q92947": ["Lysine catabolism"], "Q92952": ["Ca2+ activated K+ channels"], "Q92953": ["Voltage gated Potassium channels"], "Q92956": ["Costimulation by the CD28 family", "Costimulation by the CD28 family", "TNFs bind their physiological receptors"], "Q92959": ["Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2)", "Transport of organic anions"], "Q92963": ["Signalling to p38 via RIT and RIN"], "Q92966": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "Q92968": ["E3 ubiquitin ligases ubiquitinate target proteins", "Peroxisomal protein import", "Peroxisomal protein import"], "Q92973": ["Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "Intraflagellar transport"], "Q92974": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "Q92979": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "Q92985": ["DEx/H-box helicases activate type I IFN and inflammatory cytokines production ", "Interferon gamma signaling", "TICAM1-dependent activation of IRF3/IRF7", "Interferon alpha/beta signaling", "TRAF3-dependent IRF activation pathway", "TRAF6 mediated IRF7 activation", "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon", "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling"], "Q92989": ["Cleavage of Growing Transcript in the Termination Region ", "tRNA processing in the nucleus", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "Q92990": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q92993": ["Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "DNA Damage/Telomere Stress Induced Senescence", "HATs acetylate histones", "HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Sensing of DNA Double Strand Breaks", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Nonhomologous End-Joining (NHEJ)", "Homologous DNA Pairing and Strand Exchange", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Regulation of TP53 Activity through Phosphorylation", "G2/M DNA damage checkpoint", "Estrogen-dependent gene expression"], "Q92994": ["RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter"], "Q92995": ["Ub-specific processing proteases", "Regulation of PTEN stability and activity"], "Q92997": ["TCF dependent signaling in response to WNT", "WNT mediated activation of DVL", "PCP/CE pathway", "PCP/CE pathway", "Degradation of DVL", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Negative regulation of TCF-dependent signaling by DVL-interacting proteins", "RHO GTPases Activate Formins"], "Q93008": ["Downregulation of SMAD2/3:SMAD4 transcriptional activity", "Ub-specific processing proteases", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Peroxisomal protein import", "Peroxisomal protein import", "Amyloid fiber formation"], "Q93009": ["Ub-specific processing proteases", "Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Regulation of TP53 Degradation", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Regulation of PTEN localization"], "Q93033": ["Generation of second messenger molecules"], "Q93034": ["Vif-mediated degradation of APOBEC3G", "Downregulation of ERBB2 signaling", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q93038": ["TNFs bind their physiological receptors"], "Q93050": ["ROS, RNS production in phagocytes", "Neutrophil degranulation", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "Q93063": ["HS-GAG biosynthesis", "Defective EXT2 causes exostoses 2", "Defective EXT1 causes exostoses 1, TRPS2 and CHDS"], "Q93070": ["Post-translational modification: synthesis of GPI-anchored proteins"], "Q93074": ["PPARA activates gene expression", "Generic Transcription Pathway", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "Q93075": ["XBP1(S) activates chaperone genes"], "Q93077": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "HATs acetylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "UCH proteinases", "Ub-specific processing proteases", "Metalloprotease DUBs", "Deposition of new CENPA-containing nucleosomes at the centromere", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "Q93079": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "HATs acetylate histones", "HATs acetylate histones", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Ub-specific processing proteases", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "E3 ubiquitin ligases ubiquitinate target proteins", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "Q93084": ["Pre-NOTCH Processing in Golgi", "Reduction of cytosolic Ca++ levels", "Ion homeostasis", "Ion transport by P-type ATPases"], "Q93086": ["Elevation of cytosolic Ca2+ levels", "Platelet homeostasis"], "Q93088": ["Sulfur amino acid metabolism", "Choline catabolism"], "Q93091": ["Antimicrobial peptides"], "Q93097": ["WNT ligand biogenesis and trafficking", "WNT ligand biogenesis and trafficking", "Class B/2 (Secretin family receptors)"], "Q93098": ["TCF dependent signaling in response to WNT", "WNT ligand biogenesis and trafficking", "WNT ligand biogenesis and trafficking", "Class B/2 (Secretin family receptors)", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Disassembly of the destruction complex and recruitment of AXIN to the membrane"], "Q93099": ["Phenylalanine and tyrosine catabolism"], "Q93100": ["Glycogen breakdown (glycogenolysis)", "Glycogen breakdown (glycogenolysis)"], "Q95365": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "DAP12 interactions", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "Q95604": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "Q95IE3": ["Downstream TCR signaling", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "MHC class II antigen presentation", "PD-1 signaling", "Interferon gamma signaling"], "Q969D9": ["Interleukin-7 signaling", "Interleukin-7 signaling"], "Q969E1": ["Antimicrobial peptides"], "Q969E3": ["Class B/2 (Secretin family receptors)"], "Q969F1": ["RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter"], "Q969F8": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "Q969G2": ["Regulation of expression of SLITs and ROBOs"], "Q969G3": ["RMTs methylate histone arginines", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "Q969G6": ["Vitamin B2 (riboflavin) metabolism"], "Q969H0": ["Association of TriC/CCT with target proteins during biosynthesis", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q969H0-1": ["NOTCH1 Intracellular Domain Regulates Transcription", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "Regulation of RUNX2 expression and activity", "Negative regulation of NOTCH4 signaling"], "Q969H0-4": ["NOTCH1 Intracellular Domain Regulates Transcription", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "Negative regulation of NOTCH4 signaling"], "Q969H4": ["MAP2K and MAPK activation", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF"], "Q969H6": ["tRNA processing in the nucleus"], "Q969H8": ["XBP1(S) activates chaperone genes"], "Q969I3": ["Conjugation of salicylate with glycine", "Conjugation of benzoate with glycine"], "Q969I6": ["Amino acid transport across the plasma membrane"], "Q969J2": ["Generic Transcription Pathway"], "Q969J5": ["Interleukin-20 family signaling"], "Q969K3": ["Regulation of TP53 Degradation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q969L4": ["Cleavage of Growing Transcript in the Termination Region ", "SLBP independent Processing of Histone Pre-mRNAs", "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"], "Q969M2": ["Electric Transmission Across Gap Junctions", "Gap junction assembly"], "Q969M7": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q969N2": ["Attachment of GPI anchor to uPAR"], "Q969N4": ["Amine ligand-binding receptors", "G alpha (s) signalling events"], "Q969P5": ["Neddylation", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q969Q0": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "Q969Q1": ["FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q969Q5": ["Neutrophil degranulation", "RAB geranylgeranylation"], "Q969R5": ["SUMOylation of chromatin organization proteins", "Transcriptional Regulation by E2F6"], "Q969S0": ["Transport of nucleotide sugars"], "Q969S2": ["Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "Cleavage of the damaged pyrimidine ", "APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway"], "Q969S8": ["NOTCH1 Intracellular Domain Regulates Transcription", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "HDACs deacetylate histones"], "Q969S9": ["Mitochondrial translation termination"], "Q969T4": ["Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q969T7": ["mRNA decay by 3' to 5' exoribonuclease"], "Q969U6": ["Association of TriC/CCT with target proteins during biosynthesis", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q969V1": ["Peptide ligand-binding receptors", "G alpha (q) signalling events", "G alpha (i) signalling events"], "Q969V5": ["Ub-specific processing proteases"], "Q969V6": ["SUMOylation of transcription cofactors", "RHO GTPases Activate Formins"], "Q969W0": ["Sphingolipid de novo biosynthesis"], "Q969W8": ["Generic Transcription Pathway"], "Q969W9": ["Downregulation of TGF-beta receptor signaling"], "Q969X1": ["Neutrophil degranulation"], "Q969X2": ["Sialic acid metabolism"], "Q969X6": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "Q969Y2": ["tRNA modification in the mitochondrion"], "Q969Z3": ["Phase I - Functionalization of compounds"], "Q96A00": ["RHO GTPases activate PKNs"], "Q96A05": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "Q96A08": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "HATs acetylate histones", "HATs acetylate histones", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Ub-specific processing proteases", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "E3 ubiquitin ligases ubiquitinate target proteins", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "Q96A29": ["Defective SLC35C1 causes congenital disorder of glycosylation 2C (CDG2C)", "GDP-fucose biosynthesis", "Transport of nucleotide sugars"], "Q96A32": ["Smooth Muscle Contraction"], "Q96A35": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q96A44": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q96A46": ["Mitochondrial iron-sulfur cluster biogenesis"], "Q96A54": ["AMPK inhibits chREBP transcriptional activation activity", "AMPK inhibits chREBP transcriptional activation activity"], "Q96A56": ["TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "Regulation of TP53 Activity through Phosphorylation"], "Q96A65": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Insulin processing", "VxPx cargo-targeting to cilium"], "Q96A70": ["Agmatine biosynthesis"], "Q96A72": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "Q96A83": ["Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Collagen chain trimerization"], "Q96A98": ["Class B/2 (Secretin family receptors)", "G alpha (s) signalling events"], "Q96AA3": ["Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "Defective RFT1 causes RFT1-CDG (CDG-1n)"], "Q96AC1": ["Cell-extracellular matrix interactions"], "Q96AC6": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "Q96AD5": ["Acyl chain remodeling of DAG and TAG", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "Q96AH0": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes"], "Q96AH8": ["TBC/RABGAPs", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "Q96AJ1": ["Intraflagellar transport", "Intraflagellar transport"], "Q96AJ9": ["Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network"], "Q96AP0": ["Meiotic synapsis", "Packaging Of Telomere Ends", "DNA Damage/Telomere Stress Induced Senescence"], "Q96AP7": ["Cell surface interactions at the vascular wall"], "Q96AQ7": ["Lipid particle organization"], "Q96AQ7-1": ["Assembly of active LPL and LIPC lipase complexes"], "Q96AT9": ["Pentose phosphate pathway"], "Q96AV8": ["TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest"], "Q96AX2": ["Neutrophil degranulation", "RAB geranylgeranylation"], "Q96AX9": ["Activated NOTCH1 Transmits Signal to the Nucleus", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "NOTCH2 Activation and Transmission of Signal to the Nucleus", "NOTCH3 Activation and Transmission of Signal to the Nucleus", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q96AY2": ["Resolution of D-loop Structures through Holliday Junction Intermediates", "Fanconi Anemia Pathway"], "Q96AZ6": ["Interferon alpha/beta signaling"], "Q96B01": ["HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange"], "Q96B02": ["Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q96B26": ["ATF4 activates genes", "mRNA decay by 3' to 5' exoribonuclease", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "KSRP (KHSRP) binds and destabilizes mRNA", "Major pathway of rRNA processing in the nucleolus and cytosol"], "Q96B33": ["Tight junction interactions"], "Q96B36": ["mTOR signalling", "mTORC1-mediated signalling", "AKT phosphorylates targets in the cytosol", "HSF1-dependent transactivation", "Constitutive Signaling by AKT1 E17K in Cancer"], "Q96B49": ["Mitochondrial protein import", "Pink/Parkin Mediated Mitophagy"], "Q96B86": ["Netrin-1 signaling"], "Q96B97": ["EGFR downregulation", "Negative regulation of MET activity", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "Reelin signalling pathway", "InlB-mediated entry of Listeria monocytogenes into host cell", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "Q96BA8": ["CREB3 factors activate genes"], "Q96BD0": ["Transport of organic anions"], "Q96BD5": ["HDACs deacetylate histones", "Factors involved in megakaryocyte development and platelet production"], "Q96BD6": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q96BD8": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "Q96BH1": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q96BI1": ["Organic cation transport", "Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1)"], "Q96BI3": ["Nuclear signaling by ERBB4", "Regulated proteolysis of p75NTR", "NRIF signals cell death from the nucleus", "Activated NOTCH1 Transmits Signal to the Nucleus", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "NOTCH2 Activation and Transmission of Signal to the Nucleus", "EPH-ephrin mediated repulsion of cells", "NOTCH3 Activation and Transmission of Signal to the Nucleus", "NOTCH4 Activation and Transmission of Signal to the Nucleus", "Noncanonical activation of NOTCH3", "Amyloid fiber formation"], "Q96BM1": ["Neddylation"], "Q96BM9": ["Neutrophil degranulation"], "Q96BN2": ["HATs acetylate histones"], "Q96BN8": ["Regulation of TNFR1 signaling", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes"], "Q96BP2": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q96BP3": ["mRNA Splicing - Major Pathway"], "Q96BR1": ["Stimuli-sensing channels"], "Q96BR6": ["Generic Transcription Pathway"], "Q96BT3": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Deposition of new CENPA-containing nucleosomes at the centromere", "Mitotic Prometaphase"], "Q96BT7": ["tRNA modification in the nucleus and cytosol"], "Q96BV0": ["Generic Transcription Pathway"], "Q96BY6": ["Factors involved in megakaryocyte development and platelet production"], "Q96BZ4": ["Synthesis of PG", "Synthesis of IP3 and IP4 in the cytosol", "Role of phospholipids in phagocytosis"], "Q96BZ9": ["COPII-mediated vesicle transport", "TBC/RABGAPs"], "Q96C10": ["DDX58/IFIH1-mediated induction of interferon-alpha/beta"], "Q96C24": ["Platelet degranulation "], "Q96C28": ["Generic Transcription Pathway"], "Q96C36": ["Amino acid synthesis and interconversion (transamination)"], "Q96C86": ["mRNA decay by 3' to 5' exoribonuclease"], "Q96CB8": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes"], "Q96CB9": ["rRNA modification in the mitochondrion"], "Q96CD0": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q96CD2": ["Coenzyme A biosynthesis"], "Q96CF2": ["Budding and maturation of HIV virion", "Macroautophagy", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "Q96CJ1": ["Formation of RNA Pol II elongation complex ", "RNA Polymerase II Pre-transcription Events", "RNA Polymerase II Transcription Elongation"], "Q96CM8": ["Mitochondrial Fatty Acid Beta-Oxidation"], "Q96CN9": ["Retrograde transport at the Trans-Golgi-Network"], "Q96CS2": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "Q96CS3": ["Neutrophil degranulation"], "Q96CS4": ["Generic Transcription Pathway"], "Q96CV9": ["Regulation of PLK1 Activity at G2/M Transition", "TBC/RABGAPs"], "Q96CW1": ["Nef mediated downregulation of CD28 cell surface expression", "Nef Mediated CD4 Down-regulation", "Retrograde neurotrophin signalling", "Retrograde neurotrophin signalling", "Nef Mediated CD8 Down-regulation", "Gap junction degradation", "Formation of annular gap junctions", "MHC class II antigen presentation", "EPH-ephrin mediated repulsion of cells", "Recycling pathway of L1", "Recycling pathway of L1", "WNT5A-dependent internalization of FZD4", "WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "VLDLR internalisation and degradation", "LDL clearance"], "Q96CW1-2": ["Trafficking of GluR2-containing AMPA receptors"], "Q96CW5": ["Recruitment of mitotic centrosome proteins and complexes", "Recruitment of NuMA to mitotic centrosomes"], "Q96CW9": ["Post-translational modification: synthesis of GPI-anchored proteins"], "Q96D31": ["Elevation of cytosolic Ca2+ levels", "Ion homeostasis", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "Q96D71": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "Q96D96": ["ROS, RNS production in phagocytes", "Sperm Motility And Taxes", "Neutrophil degranulation"], "Q96DA2": ["RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "Q96DA6": ["Mitochondrial protein import"], "Q96DB2": ["NOTCH1 Intracellular Domain Regulates Transcription", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants"], "Q96DC9": ["Ovarian tumor domain proteases"], "Q96DE0": ["Phosphate bond hydrolysis by NUDT proteins"], "Q96DE5": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6"], "Q96DG6": ["Phase I - Functionalization of compounds"], "Q96DI7": ["mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "Q96DN6": ["UCH proteinases"], "Q96DP5": ["Mitochondrial translation initiation"], "Q96DR4": ["Pregnenolone biosynthesis"], "Q96DR5": ["Antimicrobial peptides"], "Q96DR7": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "Q96DR8": ["Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)", "Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)", "Defective GALNT12 causes colorectal cancer 1 (CRCS1)", "Dectin-2 family", "O-linked glycosylation of mucins", "Termination of O-glycan biosynthesis"], "Q96DT6": ["Macroautophagy"], "Q96DU3": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "Q96DU7": ["Synthesis of IP3 and IP4 in the cytosol"], "Q96DV4": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q96DX5": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q96DX8": ["Olfactory Signaling Pathway"], "Q96DZ1": ["ABC-family proteins mediated transport", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Defective CFTR causes cystic fibrosis"], "Q96DZ5": ["Regulation of TNFR1 signaling"], "Q96E11": ["Mitochondrial translation termination"], "Q96E14": ["HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Regulation of TP53 Activity through Phosphorylation", "G2/M DNA damage checkpoint"], "Q96E17": ["RAB geranylgeranylation"], "Q96E22": ["Synthesis of Dolichyl-phosphate"], "Q96E29": ["Pink/Parkin Mediated Mitophagy"], "Q96E52": ["Regulation of Apoptosis"], "Q96E93": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "Q96EA4": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "Q96EB1": ["HATs acetylate histones"], "Q96EB6": ["Regulation of HSF1-mediated heat shock response", "Circadian Clock", "SIRT1 negatively regulates rRNA expression", "SIRT1 negatively regulates rRNA expression", "Regulation of FOXO transcriptional activity by acetylation", "Regulation of FOXO transcriptional activity by acetylation"], "Q96EC8": ["Golgi Associated Vesicle Biogenesis"], "Q96EE3-1": ["ISG15 antiviral mechanism", "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "RHO GTPases Activate Formins", "tRNA processing in the nucleus", "Mitotic Prometaphase"], "Q96EE3-2": ["ISG15 antiviral mechanism", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "tRNA processing in the nucleus"], "Q96EF0": ["Synthesis of PIPs at the plasma membrane"], "Q96EF6": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q96EG1": ["Glycosphingolipid metabolism", "The activation of arylsulfatases"], "Q96EH5": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "Q96EK6": ["Synthesis of UDP-N-acetyl-glucosamine"], "Q96EK7": ["PPARA activates gene expression", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "Q96EL2": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q96EL3": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q96EN8": ["Molybdenum cofactor biosynthesis"], "Q96EP0": ["Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway"], "Q96EQ8": ["Negative regulators of DDX58/IFIH1 signaling"], "Q96ES7": ["HATs acetylate histones"], "Q96EU6": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "Q96EU7": ["Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)", "O-linked glycosylation of mucins"], "Q96EV8": ["Golgi Associated Vesicle Biogenesis"], "Q96EX3": ["Intraflagellar transport"], "Q96EY5": ["Budding and maturation of HIV virion", "Membrane binding and targetting of GAG proteins", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "Q96EY7": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q96EY8": ["Cobalamin (Cbl, vitamin B12) transport and metabolism", "Defective MMAB causes methylmalonic aciduria type cblB"], "Q96EY9": ["tRNA modification in the nucleus and cytosol"], "Q96EZ8": ["HATs acetylate histones", "UCH proteinases", "DNA Damage Recognition in GG-NER"], "Q96F07": ["Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs"], "Q96F24-1": ["Nuclear Receptor transcription pathway"], "Q96F24-2": ["Nuclear Receptor transcription pathway"], "Q96F25": ["Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)"], "Q96F44": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q96F46": ["Interleukin-17 signaling"], "Q96F86": ["mRNA decay by 5' to 3' exoribonuclease"], "Q96FA3": ["Interleukin-1 signaling", "IRAK1 recruits IKK complex", "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation"], "Q96FC9": ["XBP1(S) activates chaperone genes"], "Q96FE5": ["Axonal growth inhibition (RHOA activation)"], "Q96FF9": ["Separation of Sister Chromatids", "Establishment of Sister Chromatid Cohesion", "Resolution of Sister Chromatid Cohesion"], "Q96FI4": ["Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "Cleavage of the damaged pyrimidine ", "APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway"], "Q96FJ0": ["Metalloprotease DUBs"], "Q96FJ2": ["Activation of BMF and translocation to mitochondria", "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Macroautophagy", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Intraflagellar transport", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase"], "Q96FL8": ["Transport of bile salts and organic acids, metal ions and amine compounds"], "Q96FL9": ["O-linked glycosylation of mucins"], "Q96FN5": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "Q96FS4": ["Rap1 signalling"], "Q96FT7": ["Stimuli-sensing channels"], "Q96FT9": ["Intraflagellar transport"], "Q96FV9": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA 3'-end processing"], "Q96FW1": ["Ub-specific processing proteases", "Ovarian tumor domain proteases"], "Q96FX2": ["Synthesis of diphthamide-EEF2"], "Q96FX7": ["tRNA modification in the nucleus and cytosol"], "Q96FX8": ["TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "Formation of the cornified envelope"], "Q96FZ7": ["Budding and maturation of HIV virion", "Macroautophagy", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "Q96G01": ["COPI-independent Golgi-to-ER retrograde traffic"], "Q96G03": ["Glycogen synthesis", "Neutrophil degranulation", "Glycogen breakdown (glycogenolysis)", "Galactose catabolism", "Pentose phosphate pathway"], "Q96G04": ["Protein methylation"], "Q96G21": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "Q96G23": ["Sphingolipid de novo biosynthesis"], "Q96G25": ["PPARA activates gene expression", "Generic Transcription Pathway", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "Q96G61": ["Synthesis of pyrophosphates in the cytosol"], "Q96G74": ["Ovarian tumor domain proteases", "Negative regulators of DDX58/IFIH1 signaling"], "Q96G91": ["G alpha (q) signalling events", "P2Y receptors", "G alpha (s) signalling events"], "Q96GA3": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "Q96GA7": ["Threonine catabolism"], "Q96GC5": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q96GC6": ["Generic Transcription Pathway"], "Q96GD3-2": ["Oxidative Stress Induced Senescence", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of transcription cofactors", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA methylation proteins", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription"], "Q96GD4": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA replication proteins", "RHO GTPases Activate Formins", "Regulation of TP53 Activity through Phosphorylation", "Mitotic Prometaphase", "Regulation of MECP2 expression and activity"], "Q96GE5": ["Generic Transcription Pathway"], "Q96GF1": ["ABC-family proteins mediated transport", "Defective CFTR causes cystic fibrosis", "ER Quality Control Compartment (ERQC)"], "Q96GG9": ["Neddylation"], "Q96GM1": ["Lysosphingolipid and LPA receptors"], "Q96GM5": ["RMTs methylate histone arginines", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "Q96GR2": ["Synthesis of very long-chain fatty acyl-CoAs"], "Q96GW7": ["Degradation of the extracellular matrix", "A tetrasaccharide linker sequence is required for GAG synthesis", "Chondroitin sulfate biosynthesis", "Dermatan sulfate biosynthesis", "CS/DS degradation", "ECM proteoglycans", "Defective B4GALT7 causes EDS, progeroid type", "Defective B3GAT3 causes JDSSDHD", "Defective CHST3 causes SEDCJD", "Defective CHST14 causes EDS, musculocontractural type", "Defective CHSY1 causes TPBS", "Defective B3GALT6 causes EDSP2 and SEMDJL1"], "Q96GW9": ["Mitochondrial tRNA aminoacylation"], "Q96GX1": ["Anchoring of the basal body to the plasma membrane"], "Q96GX5": ["MASTL Facilitates Mitotic Progression", "MASTL Facilitates Mitotic Progression"], "Q96GX9": ["Formation of apoptosome", "Methionine salvage pathway", "Regulation of the apoptosome activity"], "Q96GY3": ["Transcription of E2F targets under negative control by DREAM complex", "Transcription of E2F targets under negative control by DREAM complex", "Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1", "G0 and Early G1", "Polo-like kinase mediated events", "Activation of E2F1 target genes at G1/S", "Cyclin E associated events during G1/S transition ", "Cyclin A:Cdk2-associated events at S phase entry"], "Q96H20": ["Endosomal Sorting Complex Required For Transport (ESCRT)"], "Q96H22": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Deposition of new CENPA-containing nucleosomes at the centromere", "Mitotic Prometaphase"], "Q96H40": ["Generic Transcription Pathway"], "Q96H86": ["Generic Transcription Pathway"], "Q96H96": ["Mitochondrial protein import", "Mitochondrial protein import", "Ubiquinol biosynthesis"], "Q96HA1": ["ISG15 antiviral mechanism", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "tRNA processing in the nucleus"], "Q96HC4": ["Neurexins and neuroligins"], "Q96HD9": ["Aflatoxin activation and detoxification"], "Q96HE7": ["Insulin processing", "Detoxification of Reactive Oxygen Species"], "Q96HF1": ["TCF dependent signaling in response to WNT", "Negative regulation of TCF-dependent signaling by WNT ligand antagonists"], "Q96HI0": ["SUMO is proteolytically processed"], "Q96HJ5": ["Neutrophil degranulation"], "Q96HN2": ["Bicarbonate transporters"], "Q96HP0": ["Factors involved in megakaryocyte development and platelet production"], "Q96HQ0": ["Generic Transcription Pathway"], "Q96HR3": ["PPARA activates gene expression", "Generic Transcription Pathway", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "Q96HR9": ["Olfactory Signaling Pathway"], "Q96HS1-2": ["Receptor Mediated Mitophagy"], "Q96HW7": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes"], "Q96HY7": ["Glyoxylate metabolism and glycine degradation"], "Q96I15": ["Metabolism of ingested SeMet, Sec, MeSec into H2Se"], "Q96I25": ["mRNA Splicing - Major Pathway"], "Q96I27": ["Generic Transcription Pathway"], "Q96I36": ["TP53 Regulates Metabolic Genes", "Respiratory electron transport"], "Q96I59": ["Mitochondrial tRNA aminoacylation"], "Q96I99": ["Citric acid cycle (TCA cycle)"], "Q96IF1": ["Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Regulation of PLK1 Activity at G2/M Transition", "Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "Q96IG2": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q96IJ6": ["Synthesis of GDP-mannose"], "Q96IT1": ["Generic Transcription Pathway"], "Q96IU4": ["Cytosolic sulfonation of small molecules"], "Q96IV0": ["N-glycan trimming in the ER and Calnexin/Calreticulin cycle"], "Q96IW7": ["COPII-mediated vesicle transport"], "Q96IY1": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "Q96IY4": ["Metabolism of Angiotensinogen to Angiotensins", "Regulation of Complement cascade"], "Q96J01": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA 3'-end processing"], "Q96J02": ["Downregulation of ERBB4 signaling", "NOD1/2 Signaling Pathway", "Activated NOTCH1 Transmits Signal to the Nucleus", "Activated NOTCH1 Transmits Signal to the Nucleus", "Degradation of GLI1 by the proteasome", "Hedgehog 'on' state", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Negative regulators of DDX58/IFIH1 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q96J66": ["ABC-family proteins mediated transport"], "Q96J84": ["Nephrin family interactions", "Nephrin family interactions"], "Q96J92": ["Stimuli-sensing channels"], "Q96J94": ["PIWI-interacting RNA (piRNA) biogenesis"], "Q96JA1": ["Signaling by EGFR", "Negative regulation of MET activity"], "Q96JA3": ["Synthesis of PIPs at the plasma membrane"], "Q96JB2": ["COPI-mediated anterograde transport", "Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network"], "Q96JB6": ["Elastic fibre formation", "Crosslinking of collagen fibrils"], "Q96JC4": ["Generic Transcription Pathway"], "Q96JC9": ["Formation of RNA Pol II elongation complex ", "RNA Polymerase II Pre-transcription Events", "RNA Polymerase II Transcription Elongation"], "Q96JE7": ["COPII-mediated vesicle transport"], "Q96JF0": ["Sialic acid metabolism"], "Q96JH7": ["Ovarian tumor domain proteases"], "Q96JJ3": ["Regulation of actin dynamics for phagocytic cup formation", "VEGFA-VEGFR2 Pathway", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases"], "Q96JJ7": ["Platelet degranulation "], "Q96JK2": ["Neddylation"], "Q96JK9": ["Pre-NOTCH Transcription and Translation", "Pre-NOTCH Transcription and Translation", "Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "NOTCH1 Intracellular Domain Regulates Transcription", "NOTCH1 Intracellular Domain Regulates Transcription", "NOTCH2 intracellular domain regulates transcription", "NOTCH2 intracellular domain regulates transcription", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "Notch-HLH transcription pathway", "RUNX3 regulates NOTCH signaling", "RUNX3 regulates NOTCH signaling", "NOTCH3 Intracellular Domain Regulates Transcription", "NOTCH3 Intracellular Domain Regulates Transcription", "NOTCH4 Intracellular Domain Regulates Transcription", "NOTCH4 Intracellular Domain Regulates Transcription"], "Q96JL9": ["Generic Transcription Pathway"], "Q96JP0": ["Neddylation"], "Q96JT2": ["Cellular hexose transport"], "Q96JW4": ["Metal ion SLC transporters"], "Q96JY0": ["PIWI-interacting RNA (piRNA) biogenesis"], "Q96K12": ["Wax biosynthesis"], "Q96K58": ["Generic Transcription Pathway"], "Q96K75": ["Generic Transcription Pathway"], "Q96K76": ["Ub-specific processing proteases"], "Q96K83": ["RUNX2 regulates osteoblast differentiation"], "Q96KE9": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q96KK3": ["Voltage gated Potassium channels"], "Q96KK4": ["Olfactory Signaling Pathway"], "Q96KK5": ["HDACs deacetylate histones", "HATs acetylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "UCH proteinases", "Ub-specific processing proteases", "Metalloprotease DUBs"], "Q96KN8": ["Acyl chain remodelling of PE"], "Q96KN9": ["Gap junction assembly"], "Q96KP1": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Insulin processing", "VxPx cargo-targeting to cilium"], "Q96KP4": ["Glutathione synthesis and recycling"], "Q96KP6": ["Ovarian tumor domain proteases"], "Q96KQ4": ["Activation of PUMA and translocation to mitochondria", "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "TP53 Regulates Transcription of Death Receptors and Ligands", "Regulation of TP53 Activity through Association with Co-factors"], "Q96KQ7": ["Senescence-Associated Secretory Phenotype (SASP)", "PKMTs methylate histone lysines", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "Regulation of TP53 Activity through Methylation", "RNA Polymerase I Transcription Initiation", "Transcriptional Regulation by E2F6"], "Q96KS0": ["Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"], "Q96KX2": ["MHC class II antigen presentation", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic"], "Q96L21": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "Q96L33": ["Rho GTPase cycle"], "Q96L34": ["Anchoring of the basal body to the plasma membrane"], "Q96L42": ["Voltage gated Potassium channels"], "Q96L46": ["Degradation of the extracellular matrix", "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models"], "Q96L50": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q96L58": ["A tetrasaccharide linker sequence is required for GAG synthesis", "Defective B3GALT6 causes EDSP2 and SEMDJL1"], "Q96L73": ["PKMTs methylate histone lysines"], "Q96L91": ["Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "DNA Damage/Telomere Stress Induced Senescence", "HATs acetylate histones"], "Q96L93": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "Q96LA8": ["RMTs methylate histone arginines", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"], "Q96LB3": ["Intraflagellar transport", "Intraflagellar transport"], "Q96LB4": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "Q96LB8": ["Antimicrobial peptides"], "Q96LB9": ["Antimicrobial peptides"], "Q96LC7": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "Q96LC9": ["BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "Activation of BMF and translocation to mitochondria"], "Q96LD8": ["UCH proteinases", "Neddylation"], "Q96LI5": ["Deadenylation of mRNA", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "Q96LR5": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q96LT4": ["Sphingolipid de novo biosynthesis"], "Q96LT9": ["mRNA Splicing - Minor Pathway"], "Q96LW1": ["Generic Transcription Pathway"], "Q96LX8": ["Generic Transcription Pathway"], "Q96M32": ["Interconversion of nucleotide di- and triphosphates"], "Q96M96": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "Q96MA6": ["Interconversion of nucleotide di- and triphosphates"], "Q96ME1": ["FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q96MF6": ["Respiratory electron transport"], "Q96MF7": ["SUMOylation of DNA damage response and repair proteins"], "Q96MG7": ["SUMOylation of DNA damage response and repair proteins"], "Q96MI9": ["Carboxyterminal post-translational modifications of tubulin"], "Q96MK3": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "Q96MM6": ["Regulation of HSF1-mediated heat shock response"], "Q96MM7": ["HS-GAG biosynthesis"], "Q96MN2": ["IRF3 mediated activation of type 1 IFN", "Regulation of innate immune responses to cytosolic DNA", "IRF3-mediated induction of type I IFN"], "Q96MP8": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q96MR9": ["Generic Transcription Pathway"], "Q96MS0-1": ["Regulation of commissural axon pathfinding by SLIT and ROBO", "Regulation of commissural axon pathfinding by SLIT and ROBO", "Regulation of expression of SLITs and ROBOs", "ROBO receptors bind AKAP5"], "Q96MT3": ["Asymmetric localization of PCP proteins"], "Q96MT8": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "Q96MU6": ["Generic Transcription Pathway"], "Q96MU8": ["TCF dependent signaling in response to WNT", "Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling"], "Q96MW5": ["COPI-mediated anterograde transport", "Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network"], "Q96N20": ["Generic Transcription Pathway"], "Q96N22": ["Generic Transcription Pathway"], "Q96N28": ["TP53 Regulates Transcription of Genes Involved in Cytochrome C Release"], "Q96N38": ["Generic Transcription Pathway"], "Q96N66": ["Acyl chain remodelling of PI"], "Q96N67": ["MET activates RAP1 and RAC1", "Factors involved in megakaryocyte development and platelet production"], "Q96N76": ["Histidine catabolism"], "Q96N77": ["Generic Transcription Pathway"], "Q96N87": ["Amino acid transport across the plasma membrane", "Na+/Cl- dependent neurotransmitter transporters", "Defective SLC6A18 may confer susceptibility to iminoglycinuria and/or hyperglycinuria", "Defective SLC6A18 may confer susceptibility to iminoglycinuria and/or hyperglycinuria"], "Q96NA2": ["MHC class II antigen presentation"], "Q96NB3": ["Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER"], "Q96ND8": ["Generic Transcription Pathway"], "Q96NG5": ["Generic Transcription Pathway"], "Q96NG8": ["Generic Transcription Pathway"], "Q96NI8": ["Generic Transcription Pathway"], "Q96NJ3": ["Generic Transcription Pathway"], "Q96NL3": ["Generic Transcription Pathway"], "Q96NL6": ["Anchoring of the basal body to the plasma membrane"], "Q96NR8": ["Retinoid cycle disease events", "The canonical retinoid cycle in rods (twilight vision)"], "Q96NS5": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q96NT5": ["Metabolism of folate and pterines", "Iron uptake and transport"], "Q96NU7": ["Histidine catabolism"], "Q96NW4": ["RAB GEFs exchange GTP for GDP on RABs"], "Q96NW7": ["Unblocking of NMDA receptors, glutamate binding and activation", "Unblocking of NMDA receptors, glutamate binding and activation", "Ras activation upon Ca2+ influx through NMDA receptor", "RAF/MAP kinase cascade", "Neutrophil degranulation", "Negative regulation of NMDA receptor-mediated neuronal transmission", "Long-term potentiation"], "Q96NY8": ["Adherens junctions interactions", "Nectin/Necl trans heterodimerization"], "Q96NY9": ["Resolution of D-loop Structures through Holliday Junction Intermediates", "Fanconi Anemia Pathway"], "Q96P16": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes"], "Q96P20": ["Metalloprotease DUBs", "The NLRP3 inflammasome", "The NLRP3 inflammasome"], "Q96P26": ["Purine catabolism"], "Q96P44": ["Collagen biosynthesis and modifying enzymes", "Collagen chain trimerization"], "Q96P48": ["Rho GTPase cycle", "PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1"], "Q96P56": ["Sperm Motility And Taxes"], "Q96P63": ["Neutrophil degranulation"], "Q96P65": ["Orexin and neuropeptides FF and QRFP bind to their respective receptors", "G alpha (q) signalling events"], "Q96P68": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (i) signalling events"], "Q96P88": ["Hormone ligand-binding receptors", "G alpha (q) signalling events"], "Q96PC2": ["Synthesis of pyrophosphates in the cytosol"], "Q96PC3": ["Nef mediated downregulation of MHC class I complex cell surface expression", "MHC class II antigen presentation", "Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis"], "Q96PD4": ["Interleukin-17 signaling", "Interleukin-4 and Interleukin-13 signaling"], "Q96PD5": ["Antimicrobial peptides"], "Q96PD6": ["Triglyceride biosynthesis"], "Q96PD7": ["Acyl chain remodeling of DAG and TAG", "Triglyceride biosynthesis"], "Q96PE2": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "Q96PE3": ["Synthesis of PIPs at the plasma membrane", "Synthesis of PIPs at the early endosome membrane", "Synthesis of IP2, IP, and Ins in the cytosol"], "Q96PE6": ["Generic Transcription Pathway"], "Q96PE7": ["Propionyl-CoA catabolism"], "Q96PH1": ["Detoxification of Reactive Oxygen Species"], "Q96PH6": ["Beta defensins", "Defensins"], "Q96PK6": ["RUNX2 regulates bone development"], "Q96PL1": ["Scavenging by Class A Receptors", "Scavenging by Class A Receptors"], "Q96PL2": ["Post-translational modification: synthesis of GPI-anchored proteins"], "Q96PM5": ["Translesion Synthesis by POLH", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q96PM9": ["TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "Regulation of TP53 Activity through Association with Co-factors", "Transcriptional activation of cell cycle inhibitor p21 "], "Q96PN6": ["Hedgehog 'off' state"], "Q96PP8": ["Interferon gamma signaling"], "Q96PP9": ["Interferon gamma signaling"], "Q96PQ1": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "Q96PQ6": ["Generic Transcription Pathway"], "Q96PQ7": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q96PR1": ["Voltage gated Potassium channels", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion"], "Q96PS8": ["Passive transport by Aquaporins"], "Q96PU4": ["SUMOylation of transcription cofactors"], "Q96PU5": ["Budding and maturation of HIV virion", "Downregulation of TGF-beta receptor signaling", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "Stimuli-sensing channels", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q96PU8": ["Signaling by BRAF and RAF fusions"], "Q96PV0": ["Regulation of RAS by GAPs", "Signaling by RAS mutants"], "Q96PX8": ["Receptor-type tyrosine-protein phosphatases"], "Q96PY5": ["RHO GTPases Activate Formins"], "Q96PZ0": ["tRNA modification in the nucleus and cytosol"], "Q96Q05": ["COPII-mediated vesicle transport", "RAB GEFs exchange GTP for GDP on RABs"], "Q96Q11": ["tRNA processing in the nucleus", "tRNA processing in the mitochondrion"], "Q96Q15": ["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "Q96Q27": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q96Q42": ["RAB GEFs exchange GTP for GDP on RABs"], "Q96Q80": ["ABC-family proteins mediated transport", "Defective CFTR causes cystic fibrosis"], "Q96Q83": ["ALKBH3 mediated reversal of alkylation damage"], "Q96Q89": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "Q96Q91": ["Bicarbonate transporters"], "Q96QB1": ["Rho GTPase cycle"], "Q96QD5": ["Rho GTPase cycle"], "Q96QD8": ["Glutamate Neurotransmitter Release Cycle", "Amino acid transport across the plasma membrane"], "Q96QD9": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA 3'-end processing"], "Q96QE2": ["Inositol transporters"], "Q96QF0": ["Anchoring of the basal body to the plasma membrane", "VxPx cargo-targeting to cilium", "BBSome-mediated cargo-targeting to cilium", "RAB GEFs exchange GTP for GDP on RABs"], "Q96QG7": ["Synthesis of PIPs at the plasma membrane", "Synthesis of PIPs at the late endosome membrane", "Synthesis of IP2, IP, and Ins in the cytosol"], "Q96QI5": ["HS-GAG biosynthesis"], "Q96QK1": ["WNT ligand biogenesis and trafficking"], "Q96QT4": ["TRP channels"], "Q96QV1": ["Ligand-receptor interactions"], "Q96QV6": ["HDACs deacetylate histones", "HATs acetylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "UCH proteinases", "Ub-specific processing proteases", "Metalloprotease DUBs"], "Q96R08": ["Olfactory Signaling Pathway"], "Q96R09": ["Olfactory Signaling Pathway"], "Q96R27": ["Olfactory Signaling Pathway"], "Q96R28": ["Olfactory Signaling Pathway"], "Q96R30": ["Olfactory Signaling Pathway"], "Q96R45": ["Olfactory Signaling Pathway"], "Q96R47": ["Olfactory Signaling Pathway"], "Q96R48": ["Olfactory Signaling Pathway"], "Q96R54": ["Olfactory Signaling Pathway"], "Q96R67": ["Olfactory Signaling Pathway"], "Q96R69": ["Olfactory Signaling Pathway"], "Q96R72": ["Olfactory Signaling Pathway"], "Q96R84": ["Olfactory Signaling Pathway"], "Q96RA2": ["Olfactory Signaling Pathway"], "Q96RB7": ["Olfactory Signaling Pathway"], "Q96RC9": ["Olfactory Signaling Pathway"], "Q96RD0": ["Olfactory Signaling Pathway"], "Q96RD1": ["Olfactory Signaling Pathway"], "Q96RD2": ["Olfactory Signaling Pathway"], "Q96RD3": ["Olfactory Signaling Pathway"], "Q96RD6": ["Electric Transmission Across Gap Junctions"], "Q96RD7": ["Electric Transmission Across Gap Junctions", "The NLRP3 inflammasome"], "Q96RE9": ["Generic Transcription Pathway"], "Q96RF0": ["Clathrin-mediated endocytosis"], "Q96RI0": ["Peptide ligand-binding receptors", "G alpha (q) signalling events", "Thrombin signalling through proteinase activated receptors (PARs)", "Thrombin signalling through proteinase activated receptors (PARs)"], "Q96RI1": ["Recycling of bile acids and salts", "Synthesis of bile acids and bile salts", "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "PPARA activates gene expression", "Endogenous sterols"], "Q96RI1-1": ["Nuclear Receptor transcription pathway"], "Q96RI1-2": ["Nuclear Receptor transcription pathway", "SUMOylation of intracellular receptors"], "Q96RI1-3": ["Nuclear Receptor transcription pathway"], "Q96RI1-4": ["Nuclear Receptor transcription pathway"], "Q96RI8": ["Amine ligand-binding receptors", "G alpha (s) signalling events"], "Q96RI9": ["Amine ligand-binding receptors", "G alpha (s) signalling events"], "Q96RJ0": ["Amine ligand-binding receptors", "G alpha (s) signalling events"], "Q96RJ3": ["TNFR2 non-canonical NF-kB pathway", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "Q96RK1": ["Activation of the TFAP2 (AP-2) family of transcription factors"], "Q96RK4": ["BBSome-mediated cargo-targeting to cilium"], "Q96RL1": ["Metalloprotease DUBs", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "G2/M DNA damage checkpoint"], "Q96RL6": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "Q96RM1": ["Formation of the cornified envelope"], "Q96RN5": ["PPARA activates gene expression", "Generic Transcription Pathway", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "Q96RP3": ["Class B/2 (Secretin family receptors)"], "Q96RP8": ["Voltage gated Potassium channels"], "Q96RP9": ["Mitochondrial translation elongation", "Mitochondrial translation elongation"], "Q96RQ3": ["Biotin transport and metabolism", "Defective HLCS causes multiple carboxylase deficiency", "Branched-chain amino acid catabolism"], "Q96RQ9": ["Phenylalanine and tyrosine catabolism"], "Q96RR1": ["Transcriptional activation of mitochondrial biogenesis"], "Q96RR4": ["CaMK IV-mediated phosphorylation of CREB", "CaMK IV-mediated phosphorylation of CREB", "CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "Activation of RAC1 downstream of NMDARs", "Activation of RAC1 downstream of NMDARs", "Activation of AMPK downstream of NMDARs"], "Q96RS0": ["RORA activates gene expression", "BMAL1:CLOCK,NPAS2 activates circadian gene expression", "snRNP Assembly", "PPARA activates gene expression", "PPARA activates gene expression", "Transcriptional activation of mitochondrial biogenesis", "Activation of gene expression by SREBF (SREBP)", "Transcriptional regulation of white adipocyte differentiation", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)", "Circadian Clock"], "Q96RT1": ["Signaling by ERBB2", "Downregulation of ERBB2 signaling"], "Q96RT7": ["Recruitment of mitotic centrosome proteins and complexes", "Recruitment of NuMA to mitotic centrosomes"], "Q96RT8": ["Recruitment of mitotic centrosome proteins and complexes", "Recruitment of NuMA to mitotic centrosomes"], "Q96RU2": ["Ub-specific processing proteases"], "Q96RU3": ["Clathrin-mediated endocytosis"], "Q96RU7": ["PIP3 activates AKT signaling", "Activation of AKT2", "PPARA activates gene expression", "Negative regulation of the PI3K/AKT network", "CD28 dependent PI3K/Akt signaling", "VEGFR2 mediated vascular permeability"], "Q96RY7": ["Hedgehog 'off' state", "Intraflagellar transport"], "Q96S06": ["Assembly of active LPL and LIPC lipase complexes"], "Q96S21": ["RAB geranylgeranylation"], "Q96S37": ["Organic anion transport", "Defective SLC22A12 causes renal hypouricemia 1 (RHUC1)"], "Q96S42": ["Signaling by NODAL", "Regulation of signaling by NODAL"], "Q96S44": ["tRNA modification in the nucleus and cytosol", "Regulation of TP53 Activity through Phosphorylation"], "Q96S52": ["Attachment of GPI anchor to uPAR"], "Q96S59": ["L1CAM interactions", "RAF/MAP kinase cascade", "MET activates RAS signaling"], "Q96SA4": ["Serine biosynthesis"], "Q96SB8": ["SUMOylation of DNA damage response and repair proteins"], "Q96SD1": ["Nonhomologous End-Joining (NHEJ)"], "Q96SE7": ["Generic Transcription Pathway"], "Q96SI1": ["Negative regulation of activity of TFAP2 (AP-2) family transcription factors"], "Q96SK3": ["Generic Transcription Pathway"], "Q96SL4": ["Detoxification of Reactive Oxygen Species"], "Q96SN7": ["Elevation of cytosolic Ca2+ levels", "Ion homeostasis", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "Q96SN8": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "Q96SQ5": ["Generic Transcription Pathway"], "Q96SQ9": ["Miscellaneous substrates", "Xenobiotics", "CYP2E1 reactions"], "Q96SR6": ["Generic Transcription Pathway"], "Q96ST2": ["Formation of RNA Pol II elongation complex ", "RNA Polymerase II Pre-transcription Events", "RNA Polymerase II Transcription Elongation"], "Q96ST3": ["SUMOylation of transcription cofactors", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)", "NoRC negatively regulates rRNA expression", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Loss of MECP2 binding ability to 5mC-DNA", "Regulation of MECP2 expression and activity", "MECP2 regulates neuronal receptors and channels", "MECP2 regulates transcription of neuronal ligands", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "Factors involved in megakaryocyte development and platelet production"], "Q96ST8": ["Anchoring of the basal body to the plasma membrane"], "Q96SU4": ["Synthesis of bile acids and bile salts"], "Q96SY0": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes"], "Q96SZ4": ["Transcriptional regulation of pluripotent stem cells"], "Q96SZ5": ["Degradation of cysteine and homocysteine"], "Q96T21": ["Selenocysteine synthesis"], "Q96T23": ["Deposition of new CENPA-containing nucleosomes at the centromere"], "Q96T51": ["Synthesis of PIPs at the plasma membrane"], "Q96T53": ["Synthesis, secretion, and deacylation of Ghrelin"], "Q96T54": ["TWIK-related alkaline pH activated K+ channel (TALK)", "Phase 4 - resting membrane potential"], "Q96T55": ["TWIK-related alkaline pH activated K+ channel (TALK)", "Phase 4 - resting membrane potential"], "Q96T60": ["APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway"], "Q96T66": ["Nicotinate metabolism"], "Q96T68": ["PKMTs methylate histone lysines"], "Q96T76": ["Cytosolic iron-sulfur cluster assembly"], "Q96T83": ["Sodium/Proton exchangers"], "Q96T88": ["DNA methylation"], "Q96T91": ["Hormone ligand-binding receptors", "G alpha (s) signalling events"], "Q96TA2": ["Processing of SMDT1"], "Q98325": ["Caspase activation via Death Receptors in the presence of ligand"], "Q99062": ["Other interleukin signaling"], "Q99075": ["Signaling by ERBB2", "Signaling by ERBB4", "SHC1 events in ERBB2 signaling", "SHC1 events in ERBB2 signaling", "PI3K events in ERBB4 signaling", "SHC1 events in ERBB4 signaling", "Nuclear signaling by ERBB4", "PIP3 activates AKT signaling", "Signaling by EGFR", "GRB2 events in EGFR signaling", "GAB1 signalosome", "SHC1 events in EGFR signaling", "EGFR downregulation", "GRB2 events in ERBB2 signaling", "PI3K events in ERBB2 signaling", "EGFR interacts with phospholipase C-gamma", "EGFR Transactivation by Gastrin", "EGFR Transactivation by Gastrin", "Constitutive Signaling by Aberrant PI3K in Cancer", "Uptake and function of diphtheria toxin", "Inhibition of Signaling by Overexpressed EGFR", "RAF/MAP kinase cascade", "ERBB2 Regulates Cell Motility", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "ERBB2 Activates PTK6 Signaling", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "PTK6 promotes HIF1A stabilization", "Downregulation of ERBB2 signaling"], "Q99081": ["CDO in myogenesis", "CDO in myogenesis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs"], "Q99102": ["Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)", "Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)", "Defective GALNT12 causes colorectal cancer 1 (CRCS1)", "Dectin-2 family", "O-linked glycosylation of mucins", "Termination of O-glycan biosynthesis"], "Q99217": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "Q99250": ["Interaction between L1 and Ankyrins", "Phase 0 - rapid depolarisation"], "Q99259": ["GABA synthesis", "GABA synthesis, release, reuptake and degradation", "MECP2 regulates transcription of genes involved in GABA signaling"], "Q99418": ["Intra-Golgi traffic"], "Q99424": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Beta-oxidation of pristanoyl-CoA", "Peroxisomal protein import", "Peroxisomal protein import"], "Q99426": ["Post-chaperonin tubulin folding pathway"], "Q99435": ["Regulation of commissural axon pathfinding by SLIT and ROBO"], "Q99436": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "Neutrophil degranulation", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q99437": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "Q99439": ["Neutrophil degranulation", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "Q99442": ["XBP1(S) activates chaperone genes"], "Q99447": ["Synthesis of PE"], "Q99456": ["Keratinization", "Formation of the cornified envelope"], "Q99459": ["mRNA Splicing - Major Pathway"], "Q99460": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "Neutrophil degranulation", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q99466": ["Pre-NOTCH Processing in the Endoplasmic Reticulum", "Pre-NOTCH Transcription and Translation", "Pre-NOTCH Processing in Golgi", "Pre-NOTCH Processing in Golgi", "Notch-HLH transcription pathway", "Defective LFNG causes SCDO3", "NOTCH4 Intracellular Domain Regulates Transcription", "NOTCH4 Intracellular Domain Regulates Transcription", "NOTCH4 Activation and Transmission of Signal to the Nucleus", "NOTCH4 Activation and Transmission of Signal to the Nucleus", "Negative regulation of NOTCH4 signaling", "Negative regulation of NOTCH4 signaling"], "Q99467": ["Toll Like Receptor 4 (TLR4) Cascade"], "Q99471": ["Prefoldin mediated transfer of substrate to CCT/TriC"], "Q99487": ["Platelet homeostasis"], "Q99489": ["Glyoxylate metabolism and glycine degradation", "Peroxisomal protein import", "Peroxisomal protein import"], "Q99490": ["Netrin-1 signaling"], "Q99496": ["Oxidative Stress Induced Senescence", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of transcription cofactors", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA methylation proteins", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription", "Transcriptional Regulation by E2F6"], "Q99497": ["SUMOylation of transcription cofactors"], "Q99500": ["G alpha (i) signalling events", "Lysosphingolipid and LPA receptors"], "Q99502": ["Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"], "Q99504": ["Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"], "Q99518": ["FMO oxidises nucleophiles"], "Q99519": ["Glycosphingolipid metabolism", "Sialic acid metabolism", "Defective NEU1 causes sialidosis", "Neutrophil degranulation"], "Q99523": ["Golgi Associated Vesicle Biogenesis"], "Q99527": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "Q99536": ["Neutrophil degranulation"], "Q99538": ["Trafficking and processing of endosomal TLR", "Vitamin D (calciferol) metabolism", "MHC class II antigen presentation"], "Q99541": ["PPARA activates gene expression"], "Q99542": ["Collagen degradation", "Degradation of the extracellular matrix", "Degradation of the extracellular matrix"], "Q99543": ["Regulation of HSF1-mediated heat shock response"], "Q99547": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "Q99551": ["Mitochondrial transcription termination", "Transcriptional activation of mitochondrial biogenesis"], "Q99558": ["CD28 dependent PI3K/Akt signaling", "Dectin-1 mediated noncanonical NF-kB signaling", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "Q99567": ["ISG15 antiviral mechanism", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "tRNA processing in the nucleus"], "Q99569": ["Keratinization", "Formation of the cornified envelope"], "Q99570": ["PI3K Cascade", "Macroautophagy", "Synthesis of PIPs at the Golgi membrane", "Synthesis of PIPs at the early endosome membrane", "Synthesis of PIPs at the late endosome membrane", "Toll Like Receptor 9 (TLR9) Cascade", "RHO GTPases Activate NADPH Oxidases"], "Q99571": ["Elevation of cytosolic Ca2+ levels", "Platelet homeostasis"], "Q99572": ["Elevation of cytosolic Ca2+ levels", "Platelet homeostasis", "The NLRP3 inflammasome", "The NLRP3 inflammasome"], "Q99575": ["tRNA processing in the nucleus"], "Q99576": ["Stimuli-sensing channels"], "Q99578": ["Signalling to p38 via RIT and RIN"], "Q99593": ["YAP1- and WWTR1 (TAZ)-stimulated gene expression", "Physiological factors"], "Q99594": ["YAP1- and WWTR1 (TAZ)-stimulated gene expression", "RUNX3 regulates YAP1-mediated transcription"], "Q99595": ["Mitochondrial protein import", "Mitochondrial protein import"], "Q99598": ["Small interfering RNA (siRNA) biogenesis"], "Q99608": ["Interleukin-4 and Interleukin-13 signaling"], "Q99611": ["Selenocysteine synthesis"], "Q99613": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "Q99615": ["Regulation of HSF1-mediated heat shock response"], "Q99616": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "Q99619": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q99623": ["Processing of SMDT1"], "Q99624": ["Amino acid transport across the plasma membrane"], "Q99626": ["Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)"], "Q99627": ["DNA Damage Recognition in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Cargo recognition for clathrin-mediated endocytosis", "Neddylation"], "Q99638": ["Activation of ATR in response to replication stress", "HDR through Single Strand Annealing (SSA)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Regulation of TP53 Activity through Phosphorylation", "G2/M DNA damage checkpoint"], "Q99640": ["Polo-like kinase mediated events", "Cyclin A/B1/B2 associated events during G2/M transition", "Cyclin A/B1/B2 associated events during G2/M transition", "G2/M DNA replication checkpoint"], "Q99643": ["Respiratory electron transport", "Citric acid cycle (TCA cycle)"], "Q99650": ["IL-6-type cytokine receptor ligand interactions"], "Q99653": ["Hyaluronan uptake and degradation"], "Q99661": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "COPI-dependent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "Kinesins"], "Q99665": ["Interleukin-35 Signalling", "Interleukin-12 signaling", "Interleukin-12 signaling"], "Q99676": ["Generic Transcription Pathway"], "Q99677": ["G alpha (q) signalling events", "P2Y receptors"], "Q99678": ["G alpha (s) signalling events"], "Q99683": ["Oxidative Stress Induced Senescence", "Oxidative Stress Induced Senescence"], "Q99685": ["Acyl chain remodeling of DAG and TAG", "Triglyceride catabolism", "Arachidonate production from DAG"], "Q99697": ["TFAP2 (AP-2) family regulates transcription of other transcription factors"], "Q99704": ["PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "RET signaling"], "Q99705": ["Peptide ligand-binding receptors", "G alpha (q) signalling events", "G alpha (i) signalling events", "BBSome-mediated cargo-targeting to cilium"], "Q99706": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "Q99707": ["Methylation", "Sulfur amino acid metabolism", "Cobalamin (Cbl, vitamin B12) transport and metabolism", "Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE", "Defective MTR causes methylmalonic aciduria and homocystinuria type cblG"], "Q99708": ["HDR through Single Strand Annealing (SSA)", "HDR through MMEJ (alt-NHEJ)", "HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Regulation of TP53 Activity through Phosphorylation", "G2/M DNA damage checkpoint", "Transcriptional Regulation by E2F6", "Meiotic recombination"], "Q99712": ["Activation of G protein gated Potassium channels", "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "Q99714": ["tRNA processing in the mitochondrion", "tRNA modification in the mitochondrion", "Branched-chain amino acid catabolism", "rRNA processing in the mitochondrion"], "Q99715": ["Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Assembly of collagen fibrils and other multimeric structures", "Collagen chain trimerization"], "Q99717": ["Signaling by BMP"], "Q99726": ["Zinc efflux and compartmentalization by the SLC30 family"], "Q99728": ["HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "UCH proteinases", "Metalloprotease DUBs", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Nonhomologous End-Joining (NHEJ)", "Homologous DNA Pairing and Strand Exchange", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Regulation of TP53 Activity through Phosphorylation", "G2/M DNA damage checkpoint"], "Q99731": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events", "Interleukin-10 signaling"], "Q99735": ["Glutathione conjugation", "Aflatoxin activation and detoxification"], "Q99741": ["Transcription of E2F targets under negative control by DREAM complex", "Activation of ATR in response to replication stress", "Activation of E2F1 target genes at G1/S", "CDC6 association with the ORC:origin complex", "CDT1 association with the CDC6:ORC:origin complex", "Assembly of the pre-replicative complex", "Orc1 removal from chromatin", "Activation of the pre-replicative complex", "CDK-mediated phosphorylation and removal of Cdc6"], "Q99743": ["BMAL1:CLOCK,NPAS2 activates circadian gene expression", "BMAL1:CLOCK,NPAS2 activates circadian gene expression", "PPARA activates gene expression", "PPARA activates gene expression", "Circadian Clock", "Circadian Clock"], "Q99747": ["COPII-mediated vesicle transport", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network"], "Q99748": ["NCAM1 interactions", "RAF/MAP kinase cascade", "RET signaling"], "Q99755": ["Synthesis of PIPs at the plasma membrane", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "Q99757": ["Degradation of cysteine and homocysteine", "Detoxification of Reactive Oxygen Species"], "Q99758": ["ABC transporters in lipid homeostasis", "Defective ABCA3 causes pulmonary surfactant metabolism dysfunction type 3 (SMDP3)", "Surfactant metabolism", "Defective ABCA3 causes pulmonary surfactant metabolism dysfunction 3 (SMDP3)"], "Q99759": ["Interleukin-1 signaling"], "Q99766": ["Formation of ATP by chemiosmotic coupling", "Cristae formation"], "Q99767": ["Neurexins and neuroligins"], "Q99788": ["Class A/1 (Rhodopsin-like receptors)"], "Q99798": ["Mitochondrial protein import", "Citric acid cycle (TCA cycle)"], "Q99807": ["Ubiquinol biosynthesis"], "Q99808": ["Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"], "Q99814": ["Regulation of gene expression by Hypoxia-inducible Factor", "Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Transcriptional regulation of pluripotent stem cells", "PTK6 Expression", "Neddylation"], "Q99816": ["Budding and maturation of HIV virion", "Membrane binding and targetting of GAG proteins", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "Q99819": ["Rho GTPase cycle"], "Q99829": ["Glycerophospholipid biosynthesis", "Neutrophil degranulation"], "Q99832": ["Prefoldin mediated transfer of substrate to CCT/TriC", "Formation of tubulin folding intermediates by CCT/TriC", "Folding of actin by CCT/TriC", "Association of TriC/CCT with target proteins during biosynthesis", "Association of TriC/CCT with target proteins during biosynthesis", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "Q99835": ["Class B/2 (Secretin family receptors)", "Hedgehog 'off' state", "BBSome-mediated cargo-targeting to cilium", "Hedgehog 'on' state", "Activation of SMO", "Activation of SMO"], "Q99836": ["ER-Phagosome pathway", "PIP3 activates AKT signaling", "MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "RIP-mediated NFkB activation via ZBP1", "p75NTR recruits signalling complexes", "p75NTR recruits signalling complexes", "DEx/H-box helicases activate type I IFN and inflammatory cytokines production ", "MyD88 deficiency (TLR2/4)", "MyD88 deficiency (TLR5)", "IRAK4 deficiency (TLR5)", "IRAK4 deficiency (TLR2/4)", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Interleukin-1 signaling", "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "MyD88 dependent cascade initiated on endosome", "MyD88 cascade initiated on plasma membrane"], "Q99848": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "Q99856": ["TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest"], "Q99871": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "Q99873": ["RMTs methylate histone arginines", "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "Q99877": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "HATs acetylate histones", "HATs acetylate histones", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Ub-specific processing proteases", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "E3 ubiquitin ligases ubiquitinate target proteins", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "Q99878": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "HATs acetylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "UCH proteinases", "Ub-specific processing proteases", "Metalloprotease DUBs", "Deposition of new CENPA-containing nucleosomes at the centromere", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "Q99879": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "HATs acetylate histones", "HATs acetylate histones", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Ub-specific processing proteases", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "E3 ubiquitin ligases ubiquitinate target proteins", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "Q99880": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HDACs deacetylate histones", "HATs acetylate histones", "HATs acetylate histones", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Ub-specific processing proteases", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "E3 ubiquitin ligases ubiquitinate target proteins", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination", "Amyloid fiber formation"], "Q99884": ["Na+/Cl- dependent neurotransmitter transporters", "Creatine metabolism"], "Q99895": ["Cobalamin (Cbl, vitamin B12) transport and metabolism"], "Q99928": ["GABA A receptor activation", "GABA receptor activation"], "Q99933": ["Regulation of HSF1-mediated heat shock response"], "Q99942": ["ABC-family proteins mediated transport", "Defective CFTR causes cystic fibrosis", "ER Quality Control Compartment (ERQC)"], "Q99943": ["Synthesis of PA", "ChREBP activates metabolic gene expression"], "Q99952": ["Downregulation of ERBB2 signaling", "Interleukin-37 signaling"], "Q99956": ["RAF-independent MAPK1/3 activation", "Negative regulation of MAPK pathway"], "Q99959": ["Keratinization", "Formation of the cornified envelope"], "Q99961": ["EGFR downregulation", "Negative regulation of MET activity", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "InlB-mediated entry of Listeria monocytogenes into host cell"], "Q99962": ["Retrograde neurotrophin signalling", "Retrograde neurotrophin signalling", "EGFR downregulation", "MHC class II antigen presentation", "Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis", "Recycling pathway of L1", "Recycling pathway of L1", "Negative regulation of MET activity", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "InlB-mediated entry of Listeria monocytogenes into host cell"], "Q99963": ["EGFR downregulation", "Negative regulation of MET activity", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "InlB-mediated entry of Listeria monocytogenes into host cell"], "Q99965": ["Interaction With The Zona Pellucida"], "Q99966": ["Activation of the TFAP2 (AP-2) family of transcription factors", "Estrogen-dependent gene expression"], "Q99967": ["Regulation of gene expression by Hypoxia-inducible Factor", "TFAP2 (AP-2) family regulates transcription of other transcription factors", "Activation of the TFAP2 (AP-2) family of transcription factors", "FOXO-mediated transcription of cell death genes"], "Q99969": ["Platelet degranulation "], "Q99983": ["Keratan sulfate biosynthesis", "Keratan sulfate degradation", "Defective CHST6 causes MCDC1", "Defective ST3GAL3 causes MCT12 and EIEE15", "Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)"], "Q99986": ["Clearance of Nuclear Envelope Membranes from Chromatin", "Initiation of Nuclear Envelope Reformation"], "Q99996": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Phase 3 - rapid repolarisation", "Phase 2 - plateau phase", "Anchoring of the basal body to the plasma membrane", "Signaling by BRAF and RAF fusions", "AURKA Activation by TPX2"], "Q99IB8": ["Dectin-2 family"], "Q9BPU6": ["CRMPs in Sema3A signaling"], "Q9BPU9": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Anchoring of the basal body to the plasma membrane", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "Q9BPV8": ["P2Y receptors", "G alpha (i) signalling events"], "Q9BPW9": ["The canonical retinoid cycle in rods (twilight vision)", "RA biosynthesis pathway"], "Q9BPX1": ["Estrogen biosynthesis"], "Q9BPX3": ["Condensation of Prometaphase Chromosomes", "Condensation of Prometaphase Chromosomes"], "Q9BPX6": ["Mitochondrial calcium ion transport", "Processing of SMDT1"], "Q9BPZ7": ["PIP3 activates AKT signaling", "CD28 dependent PI3K/Akt signaling", "VEGFR2 mediated vascular permeability", "Constitutive Signaling by AKT1 E17K in Cancer", "Regulation of TP53 Degradation"], "Q9BQ15": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes"], "Q9BQ16": ["Activation of Matrix Metalloproteinases"], "Q9BQ31": ["Voltage gated Potassium channels", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion"], "Q9BQ48": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q9BQ51": ["PD-1 signaling"], "Q9BQ52": ["tRNA processing in the nucleus", "tRNA processing in the mitochondrion", "rRNA processing in the mitochondrion"], "Q9BQ83": ["Resolution of D-loop Structures through Holliday Junction Intermediates", "Fanconi Anemia Pathway"], "Q9BQ90": ["XBP1(S) activates chaperone genes"], "Q9BQ95": ["MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "Complex I biogenesis", "TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "MyD88 cascade initiated on plasma membrane"], "Q9BQA1": ["snRNP Assembly", "RMTs methylate histone arginines"], "Q9BQB4": ["TCF dependent signaling in response to WNT", "Negative regulation of TCF-dependent signaling by WNT ligand antagonists"], "Q9BQB6": ["Metabolism of vitamin K"], "Q9BQC3": ["Synthesis of diphthamide-EEF2"], "Q9BQC6": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q9BQE3": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "Gap junction assembly", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Recruitment of NuMA to mitotic centrosomes", "Prefoldin mediated transfer of substrate to CCT/TriC", "Formation of tubulin folding intermediates by CCT/TriC", "Post-chaperonin tubulin folding pathway", "Recycling pathway of L1", "Recycling pathway of L1", "Hedgehog 'off' state", "Cilium Assembly", "Intraflagellar transport", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "Carboxyterminal post-translational modifications of tubulin", "Carboxyterminal post-translational modifications of tubulin", "Activation of AMPK downstream of NMDARs", "Kinesins"], "Q9BQE4": ["E3 ubiquitin ligases ubiquitinate target proteins"], "Q9BQG0": ["B-WICH complex positively regulates rRNA expression"], "Q9BQG2": ["Nicotinamide salvaging"], "Q9BQI5": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "Q9BQK8": ["Synthesis of PC", "Synthesis of PE", "Depolymerisation of the Nuclear Lamina", "Triglyceride biosynthesis"], "Q9BQQ3": ["Golgi Cisternae Pericentriolar Stack Reorganization", "Golgi Cisternae Pericentriolar Stack Reorganization", "COPII-mediated vesicle transport", "COPI-mediated anterograde transport"], "Q9BQQ7": ["Olfactory Signaling Pathway"], "Q9BQS7": ["Metal ion SLC transporters", "Iron uptake and transport"], "Q9BQT8": ["Lysine catabolism"], "Q9BR01": ["Cytosolic sulfonation of small molecules"], "Q9BR09": ["Neddylation"], "Q9BR61": ["Mitochondrial Fatty Acid Beta-Oxidation"], "Q9BR84": ["Generic Transcription Pathway"], "Q9BRA0": ["Retrograde transport at the Trans-Golgi-Network"], "Q9BRB3-2": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "Q9BRC7": ["Synthesis of IP3 and IP4 in the cytosol"], "Q9BRF8": ["Neutrophil degranulation"], "Q9BRG1": ["Endosomal Sorting Complex Required For Transport (ESCRT)"], "Q9BRI3": ["Zinc efflux and compartmentalization by the SLC30 family"], "Q9BRJ2": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q9BRK0": ["Olfactory Signaling Pathway"], "Q9BRK3": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "Q9BRL7": ["COPII-mediated vesicle transport"], "Q9BRQ0": ["Formation of the beta-catenin:TCF transactivating complex", "Deactivation of the beta-catenin transactivating complex"], "Q9BRQ6": ["Cristae formation"], "Q9BRQ8": ["TP53 Regulates Transcription of Genes Involved in Cytochrome C Release"], "Q9BRR0": ["Generic Transcription Pathway"], "Q9BRR6": ["Glycolysis"], "Q9BRR9": ["Rho GTPase cycle", "Neutrophil degranulation"], "Q9BRS2": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "Q9BRT9": ["Unwinding of DNA", "Unwinding of DNA"], "Q9BRV3": ["Cellular hexose transport"], "Q9BRV8": ["TRAF3-dependent IRF activation pathway", "TRAF6 mediated IRF7 activation"], "Q9BRX5": ["Unwinding of DNA", "Unwinding of DNA"], "Q9BRX9": ["MAP2K and MAPK activation"], "Q9BRY0": ["Zinc influx into cells by the SLC39 gene family"], "Q9BRZ2": ["Regulation of innate immune responses to cytosolic DNA"], "Q9BS16": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Deposition of new CENPA-containing nucleosomes at the centromere", "Mitotic Prometaphase"], "Q9BS18": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q9BS26": ["Neutrophil degranulation"], "Q9BS31": ["Generic Transcription Pathway"], "Q9BS34": ["Generic Transcription Pathway"], "Q9BSA4": ["Stimuli-sensing channels"], "Q9BSB4": ["Macroautophagy"], "Q9BSD3": ["HDR through Single Strand Annealing (SSA)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Regulation of TP53 Activity through Phosphorylation", "G2/M DNA damage checkpoint"], "Q9BSE5": ["Agmatine biosynthesis"], "Q9BSG1": ["Generic Transcription Pathway"], "Q9BSH3": ["Carboxyterminal post-translational modifications of tubulin"], "Q9BSH4": ["TP53 Regulates Metabolic Genes", "Respiratory electron transport"], "Q9BSI4": ["Meiotic synapsis", "Packaging Of Telomere Ends", "DNA Damage/Telomere Stress Induced Senescence"], "Q9BSJ2": ["Recruitment of mitotic centrosome proteins and complexes", "Recruitment of NuMA to mitotic centrosomes"], "Q9BSJ8": ["Glycosphingolipid metabolism"], "Q9BSK1": ["Generic Transcription Pathway"], "Q9BSK4": ["Neddylation"], "Q9BSL1": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q9BST9": ["RHO GTPases Activate Rhotekin and Rhophilins", "RHO GTPases Activate Rhotekin and Rhophilins"], "Q9BSV6": ["tRNA processing in the nucleus"], "Q9BSW2": ["Neutrophil degranulation"], "Q9BSY4": ["Mitochondrial protein import"], "Q9BT04": ["Hedgehog 'off' state"], "Q9BT09": ["Trafficking and processing of endosomal TLR"], "Q9BT22": ["Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "Defective ALG1 causes ALG1-CDG (CDG-1k)"], "Q9BT25": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "Q9BT40": ["Synthesis of PIPs at the plasma membrane"], "Q9BT43": ["Cytosolic sensors of pathogen-associated DNA ", "RNA Polymerase III Chain Elongation", "RNA Polymerase III Transcription Termination", "RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "Q9BT78": ["DNA Damage Recognition in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Cargo recognition for clathrin-mediated endocytosis", "Neddylation"], "Q9BT81": ["Deactivation of the beta-catenin transactivating complex"], "Q9BT88": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "Q9BTA9": ["E3 ubiquitin ligases ubiquitinate target proteins"], "Q9BTC0-1": ["Meiotic synapsis"], "Q9BTC8": ["HDACs deacetylate histones", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "RNA Polymerase I Transcription Initiation", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription"], "Q9BTE1": ["MHC class II antigen presentation", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic"], "Q9BTE7": ["Neddylation"], "Q9BTK6": ["Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "Q9BTM1": ["Meiotic synapsis", "Packaging Of Telomere Ends", "Pre-NOTCH Transcription and Translation", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "NoRC negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "DNA methylation", "Transcriptional regulation by small RNAs", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Deposition of new CENPA-containing nucleosomes at the centromere", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Meiotic recombination"], "Q9BTM9": ["tRNA modification in the nucleus and cytosol"], "Q9BTN0": ["Synaptic adhesion-like molecules"], "Q9BTP7": ["Fanconi Anemia Pathway"], "Q9BTT4": ["PPARA activates gene expression", "Generic Transcription Pathway", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "Q9BTU6": ["Synthesis of PIPs at the plasma membrane", "Synthesis of PIPs at the Golgi membrane", "Synthesis of PIPs at the early endosome membrane"], "Q9BTV6": ["Synthesis of diphthamide-EEF2"], "Q9BTV7": ["Factors involved in megakaryocyte development and platelet production"], "Q9BTW9": ["Post-chaperonin tubulin folding pathway"], "Q9BTX1": ["ISG15 antiviral mechanism", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "tRNA processing in the nucleus"], "Q9BTY2": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Neutrophil degranulation", "Post-translational protein phosphorylation"], "Q9BTZ2": ["RA biosynthesis pathway", "Peroxisomal protein import", "Peroxisomal protein import"], "Q9BU02": ["Vitamin B1 (thiamin) metabolism"], "Q9BU19": ["Generic Transcription Pathway"], "Q9BU23": ["Assembly of active LPL and LIPC lipase complexes"], "Q9BU40": ["Signaling by BMP", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "Q9BU61": ["Complex I biogenesis"], "Q9BU64": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Deposition of new CENPA-containing nucleosomes at the centromere", "Mitotic Prometaphase"], "Q9BU76": ["Neutrophil degranulation"], "Q9BU89": ["Hypusine synthesis from eIF5A-lysine"], "Q9BUA6": ["Smooth Muscle Contraction"], "Q9BUB4": ["tRNA modification in the nucleus and cytosol"], "Q9BUB5": ["Spry regulation of FGF signaling"], "Q9BUD6": ["Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "Q9BUE0": ["PPARA activates gene expression", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "Q9BUE6": ["Mitochondrial iron-sulfur cluster biogenesis"], "Q9BUF5": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "Gap junction assembly", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Recruitment of NuMA to mitotic centrosomes", "Prefoldin mediated transfer of substrate to CCT/TriC", "Formation of tubulin folding intermediates by CCT/TriC", "Post-chaperonin tubulin folding pathway", "Recycling pathway of L1", "Recycling pathway of L1", "Hedgehog 'off' state", "Cilium Assembly", "Intraflagellar transport", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "Carboxyterminal post-translational modifications of tubulin", "Carboxyterminal post-translational modifications of tubulin", "Activation of AMPK downstream of NMDARs", "Kinesins"], "Q9BUF7": ["Tight junction interactions"], "Q9BUH8": ["Neurexins and neuroligins"], "Q9BUI4": ["Cytosolic sensors of pathogen-associated DNA ", "RNA Polymerase III Chain Elongation", "RNA Polymerase III Transcription Termination", "RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "Q9BUJ2": ["mRNA Splicing - Major Pathway"], "Q9BUK0": ["Mitochondrial protein import"], "Q9BUL9": ["tRNA processing in the nucleus", "Major pathway of rRNA processing in the nucleolus and cytosol"], "Q9BUM1": ["Severe congenital neutropenia type 4 (G6PC3)", "Gluconeogenesis"], "Q9BUN8": ["ABC-family proteins mediated transport", "N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "Defective CFTR causes cystic fibrosis", "E3 ubiquitin ligases ubiquitinate target proteins"], "Q9BUQ8": ["mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "Q9BUR4": ["Telomere Extension By Telomerase", "Association of TriC/CCT with target proteins during biosynthesis"], "Q9BUR5": ["Cristae formation"], "Q9BUT1": ["Synthesis of Ketone Bodies"], "Q9BUU2": ["Protein methylation"], "Q9BUX1": ["Glutathione synthesis and recycling"], "Q9BUY5": ["Generic Transcription Pathway"], "Q9BV10": ["Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "Defective ALG12 causes ALG12-CDG (CDG-1g)"], "Q9BV20": ["Methionine salvage pathway"], "Q9BV23": ["Arachidonate production from DAG"], "Q9BV38": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "Q9BV40": ["ER-Phagosome pathway", "Clathrin derived vesicle budding", "Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis", "Neutrophil degranulation", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "Q9BV57": ["Methionine salvage pathway"], "Q9BV68": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q9BV73": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "Q9BV79": ["Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA"], "Q9BV90": ["mRNA Splicing - Minor Pathway"], "Q9BV94": ["ER Quality Control Compartment (ERQC)"], "Q9BV97": ["Generic Transcription Pathway"], "Q9BVA1": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "Gap junction assembly", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Recruitment of NuMA to mitotic centrosomes", "Prefoldin mediated transfer of substrate to CCT/TriC", "Formation of tubulin folding intermediates by CCT/TriC", "Post-chaperonin tubulin folding pathway", "Recycling pathway of L1", "Recycling pathway of L1", "Hedgehog 'off' state", "Cilium Assembly", "Intraflagellar transport", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "Carboxyterminal post-translational modifications of tubulin", "Carboxyterminal post-translational modifications of tubulin", "Activation of AMPK downstream of NMDARs", "Kinesins"], "Q9BVC4": ["PIP3 activates AKT signaling", "Macroautophagy", "mTOR signalling", "mTORC1-mediated signalling", "HSF1-dependent transactivation", "Energy dependent regulation of mTOR by LKB1-AMPK", "CD28 dependent PI3K/Akt signaling", "VEGFR2 mediated vascular permeability", "TP53 Regulates Metabolic Genes", "Constitutive Signaling by AKT1 E17K in Cancer", "Regulation of TP53 Degradation", "Regulation of PTEN gene transcription"], "Q9BVC5": ["tRNA processing in the nucleus"], "Q9BVG3": ["Interferon gamma signaling"], "Q9BVG8-2": ["Association of TriC/CCT with target proteins during biosynthesis"], "Q9BVG9": ["Synthesis of PS"], "Q9BVH7": ["Sialic acid metabolism"], "Q9BVI0": ["HATs acetylate histones", "Regulation of TP53 Degradation", "Regulation of TP53 Activity through Association with Co-factors", "Stabilization of p53"], "Q9BVI4": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "Q9BVJ6": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "Q9BVK2": ["Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "Defective ALG8 causes ALG8-CDG (CDG-1h)"], "Q9BVK6": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "Q9BVL2-1": ["ISG15 antiviral mechanism", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "tRNA processing in the nucleus"], "Q9BVL2-2": ["ISG15 antiviral mechanism", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "tRNA processing in the nucleus"], "Q9BVP2": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "Q9BVS4": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "Q9BVS5": ["tRNA modification in the mitochondrion"], "Q9BVV7": ["Mitochondrial protein import"], "Q9BVW5": ["Processing of DNA double-strand break ends"], "Q9BW19": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins", "Kinesins"], "Q9BW27": ["ISG15 antiviral mechanism", "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "RHO GTPases Activate Formins", "tRNA processing in the nucleus", "Mitotic Prometaphase"], "Q9BW60": ["Linoleic acid (LA) metabolism", "alpha-linolenic acid (ALA) metabolism", "Synthesis of very long-chain fatty acyl-CoAs", "Synthesis of very long-chain fatty acyl-CoAs"], "Q9BW61": ["Neddylation"], "Q9BW83": ["Intraflagellar transport", "Intraflagellar transport"], "Q9BW91-1": ["Phosphate bond hydrolysis by NUDT proteins"], "Q9BW92": ["Mitochondrial tRNA aminoacylation"], "Q9BWD1": ["Cholesterol biosynthesis"], "Q9BWF2": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q9BWF3": ["Circadian Clock"], "Q9BWJ5": ["mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "Q9BWM5": ["Generic Transcription Pathway"], "Q9BWP8": ["Lectin pathway of complement activation", "Initial triggering of complement", "Scavenging by Class A Receptors"], "Q9BWS9": ["Platelet degranulation "], "Q9BWT6": ["Meiotic recombination"], "Q9BWU1": ["PPARA activates gene expression", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "Q9BWV1": ["Ligand-receptor interactions", "Activation of SMO"], "Q9BWV1-1": ["CDO in myogenesis", "CDO in myogenesis"], "Q9BWV7": ["Carboxyterminal post-translational modifications of tubulin"], "Q9BWX5": ["Factors involved in megakaryocyte development and platelet production"], "Q9BX10": ["Platelet degranulation "], "Q9BX26": ["Meiotic synapsis"], "Q9BX63": ["Cytosolic iron-sulfur cluster assembly", "HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Regulation of TP53 Activity through Phosphorylation", "G2/M DNA damage checkpoint"], "Q9BX66": ["Smooth Muscle Contraction"], "Q9BX67": ["Cell surface interactions at the vascular wall", "Integrin cell surface interactions"], "Q9BX79": ["Retinoid cycle disease events", "The canonical retinoid cycle in rods (twilight vision)"], "Q9BX82": ["Generic Transcription Pathway"], "Q9BX84": ["TRP channels"], "Q9BX95": ["Sphingolipid de novo biosynthesis"], "Q9BXA5": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (i) signalling events"], "Q9BXB1": ["Regulation of FZD by ubiquitination"], "Q9BXB5": ["Acyl chain remodelling of PS"], "Q9BXC0": ["Hydroxycarboxylic acid-binding receptors", "G alpha (i) signalling events"], "Q9BXC9": ["BBSome-mediated cargo-targeting to cilium"], "Q9BXD5": ["Sialic acid metabolism"], "Q9BXH1": ["BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "Activation of PUMA and translocation to mitochondria", "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "FOXO-mediated transcription of cell death genes"], "Q9BXI2": ["Urea cycle"], "Q9BXI3": ["Pyrimidine catabolism", "Purine catabolism"], "Q9BXI6": ["TBC/RABGAPs"], "Q9BXJ7": ["Cobalamin (Cbl, vitamin B12) transport and metabolism", "Defective AMN causes hereditary megaloblastic anemia 1", "Defective CUBN causes hereditary megaloblastic anemia 1", "HDL clearance"], "Q9BXL7": ["Activation of NF-kappaB in B cells", "Activation of NF-kappaB in B cells", "Downstream TCR signaling", "FCERI mediated NF-kB activation", "FCERI mediated NF-kB activation", "CLEC7A (Dectin-1) signaling"], "Q9BXM7": ["Pink/Parkin Mediated Mitophagy", "FOXO-mediated transcription of cell death genes"], "Q9BXN1": ["ECM proteoglycans"], "Q9BXN2": ["CLEC7A (Dectin-1) signaling", "CLEC7A (Dectin-1) signaling"], "Q9BXP5": ["RNA polymerase II transcribes snRNA genes", "mRNA Splicing - Major Pathway"], "Q9BXP8": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "Q9BXR0": ["tRNA modification in the nucleus and cytosol"], "Q9BXR5": ["Toll Like Receptor 10 (TLR10) Cascade", "IRAK4 deficiency (TLR5)", "MyD88 cascade initiated on plasma membrane"], "Q9BXR6": ["Regulation of Complement cascade"], "Q9BXS0": ["Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Collagen chain trimerization"], "Q9BXS1": ["Cholesterol biosynthesis"], "Q9BXS5": ["Nef mediated downregulation of MHC class I complex cell surface expression", "MHC class II antigen presentation", "Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis", "Neutrophil degranulation"], "Q9BXS9": ["Multifunctional anion exchangers"], "Q9BXT2": ["Phase 0 - rapid depolarisation", "Phase 2 - plateau phase"], "Q9BXT4": ["PIWI-interacting RNA (piRNA) biogenesis"], "Q9BXT5": ["Meiotic recombination"], "Q9BXT6": ["PIWI-interacting RNA (piRNA) biogenesis"], "Q9BXU0": ["Meiotic synapsis"], "Q9BXU7": ["Ub-specific processing proteases"], "Q9BXW4": ["Macroautophagy"], "Q9BXW6": ["Synthesis of bile acids and bile salts", "MHC class II antigen presentation"], "Q9BXW9": ["Fanconi Anemia Pathway", "TP53 Regulates Transcription of DNA Repair Genes"], "Q9BXX0": ["Molecules associated with elastic fibres", "Molecules associated with elastic fibres"], "Q9BXY4": ["Regulation of FZD by ubiquitination", "RUNX1 regulates transcription of genes involved in WNT signaling"], "Q9BY07": ["Bicarbonate transporters"], "Q9BY11": ["Clathrin-mediated endocytosis"], "Q9BY14": ["Post-translational modification: synthesis of GPI-anchored proteins"], "Q9BY15": ["Class B/2 (Secretin family receptors)", "Neutrophil degranulation"], "Q9BY31": ["Generic Transcription Pathway"], "Q9BY32": ["Purine catabolism"], "Q9BY41": ["NOTCH1 Intracellular Domain Regulates Transcription", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "HDACs deacetylate histones"], "Q9BY41-1": ["Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion"], "Q9BY43": ["Budding and maturation of HIV virion", "Macroautophagy", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "Q9BY49": ["Alpha-oxidation of phytanate", "Peroxisomal protein import", "Peroxisomal protein import"], "Q9BY50": ["SRP-dependent cotranslational protein targeting to membrane", "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)", "Synthesis, secretion, and deacylation of Ghrelin"], "Q9BY60": ["Macroautophagy"], "Q9BY64": ["Glucuronidation"], "Q9BY66": ["HDMs demethylate histones"], "Q9BY67": ["Adherens junctions interactions", "Nectin/Necl trans heterodimerization"], "Q9BY76": ["PPARA activates gene expression", "Transcriptional regulation of white adipocyte differentiation", "Assembly of active LPL and LIPC lipase complexes"], "Q9BY77": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA 3'-end processing"], "Q9BY84": ["RAF-independent MAPK1/3 activation", "Negative regulation of MAPK pathway"], "Q9BYB0": ["Neurexins and neuroligins", "Neurexins and neuroligins", "RET signaling"], "Q9BYC2": ["Utilization of Ketone Bodies"], "Q9BYC5": ["Reactions specific to the complex N-glycan synthesis pathway"], "Q9BYC8": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q9BYC9": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q9BYD1": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q9BYD2": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q9BYD3": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q9BYD6": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q9BYE3": ["Formation of the cornified envelope"], "Q9BYE4": ["Formation of the cornified envelope"], "Q9BYE7": ["Transcriptional Regulation by E2F6"], "Q9BYF1": ["Metabolism of Angiotensinogen to Angiotensins"], "Q9BYG0": ["O-linked glycosylation of mucins"], "Q9BYG4": ["Tight junction interactions"], "Q9BYG5": ["Tight junction interactions"], "Q9BYJ0": ["FGFR2b ligand binding and activation"], "Q9BYJ1": ["Synthesis of 12-eicosatetraenoic acid derivatives"], "Q9BYJ4": ["Interferon gamma signaling"], "Q9BYK8": ["RORA activates gene expression", "BMAL1:CLOCK,NPAS2 activates circadian gene expression", "PPARA activates gene expression", "PPARA activates gene expression", "Transcriptional activation of mitochondrial biogenesis", "Activation of gene expression by SREBF (SREBP)", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)", "Circadian Clock"], "Q9BYM8": ["Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q9BYN8": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q9BYP7": ["Stimuli-sensing channels"], "Q9BYP8": ["Keratinization"], "Q9BYP9": ["Keratinization"], "Q9BYQ0": ["Keratinization"], "Q9BYQ2": ["Keratinization"], "Q9BYQ3": ["Keratinization"], "Q9BYQ4": ["Keratinization"], "Q9BYQ5": ["Keratinization"], "Q9BYQ6": ["Keratinization"], "Q9BYQ7": ["Keratinization"], "Q9BYQ8": ["Keratinization"], "Q9BYQ9": ["Keratinization"], "Q9BYR0": ["Keratinization"], "Q9BYR2": ["Keratinization"], "Q9BYR3": ["Keratinization"], "Q9BYR4": ["Keratinization"], "Q9BYR5": ["Keratinization"], "Q9BYR6": ["Keratinization"], "Q9BYR7": ["Keratinization"], "Q9BYR8": ["Keratinization"], "Q9BYR9": ["Keratinization"], "Q9BYS1": ["Keratinization"], "Q9BYT5": ["Keratinization"], "Q9BYT8": ["Peptide ligand-binding receptors"], "Q9BYT9": ["Stimuli-sensing channels"], "Q9BYU5": ["Keratinization"], "Q9BYV1": ["Glyoxylate metabolism and glycine degradation", "Pyrimidine catabolism"], "Q9BYV7": ["Retinoid metabolism and transport"], "Q9BYV8": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "Q9BYW1": ["Cellular hexose transport"], "Q9BYW2": ["PKMTs methylate histone lysines"], "Q9BYW3": ["Beta defensins", "Defensins"], "Q9BYX2": ["TBC/RABGAPs"], "Q9BYX4": ["DDX58/IFIH1-mediated induction of interferon-alpha/beta", "Ub-specific processing proteases", "Ovarian tumor domain proteases", "TRAF3-dependent IRF activation pathway", "TRAF6 mediated IRF7 activation", "TRAF6 mediated NF-kB activation", "TRAF6 mediated NF-kB activation", "NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10", "Negative regulators of DDX58/IFIH1 signaling", "Negative regulators of DDX58/IFIH1 signaling"], "Q9BYX7": ["Platelet degranulation "], "Q9BYZ2": ["Pyruvate metabolism"], "Q9BYZ6": ["Rho GTPase cycle"], "Q9BZ23": ["Coenzyme A biosynthesis"], "Q9BZ29": ["Factors involved in megakaryocyte development and platelet production"], "Q9BZ71": ["Synthesis of PI"], "Q9BZ72": ["Synthesis of PI"], "Q9BZ95": ["PKMTs methylate histone lysines"], "Q9BZC7": ["ABC transporters in lipid homeostasis"], "Q9BZD2": ["Defective SLC29A3 causes histiocytosis-lymphadenopathy plus syndrome (HLAS)", "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"], "Q9BZD4": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "Q9BZE1": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q9BZE2": ["tRNA modification in the nucleus and cytosol"], "Q9BZE9": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane"], "Q9BZF1": ["Acyl chain remodelling of PS"], "Q9BZF2": ["Synthesis of bile acids and bile salts"], "Q9BZF3": ["Synthesis of bile acids and bile salts"], "Q9BZF9": ["Regulation of the apoptosome activity"], "Q9BZG1": ["RAB geranylgeranylation"], "Q9BZG8": ["Synthesis of diphthamide-EEF2"], "Q9BZI7": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "Q9BZJ0": ["mRNA Splicing - Major Pathway"], "Q9BZK7": ["RORA activates gene expression", "BMAL1:CLOCK,NPAS2 activates circadian gene expression", "PPARA activates gene expression", "PPARA activates gene expression", "NOTCH1 Intracellular Domain Regulates Transcription", "Transcriptional activation of mitochondrial biogenesis", "Activation of gene expression by SREBF (SREBP)", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "HDACs deacetylate histones", "Transcriptional regulation of white adipocyte differentiation", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)", "Circadian Clock", "Loss of MECP2 binding ability to the NCoR/SMRT complex", "Regulation of MECP2 expression and activity"], "Q9BZL6": ["Sphingolipid de novo biosynthesis"], "Q9BZM1": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PS", "Acyl chain remodelling of PE", "Acyl chain remodelling of PI", "Acyl chain remodelling of PG", "Synthesis of PA"], "Q9BZM2": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PS", "Acyl chain remodelling of PE", "Acyl chain remodelling of PI", "Acyl chain remodelling of PG", "Synthesis of PA"], "Q9BZM4": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "Q9BZM5": ["Post-translational modification: synthesis of GPI-anchored proteins"], "Q9BZM6": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "Q9BZP6": ["Digestion of dietary carbohydrate"], "Q9BZQ4": ["Nicotinate metabolism"], "Q9BZQ6": ["ER Quality Control Compartment (ERQC)"], "Q9BZR6": ["Axonal growth inhibition (RHOA activation)"], "Q9BZR8": ["TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain"], "Q9BZR9": ["Interferon gamma signaling"], "Q9BZS1": ["RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "RUNX1 regulates transcription of genes involved in WNT signaling"], "Q9BZV2": ["Vitamin B1 (thiamin) metabolism"], "Q9BZW2": ["Sodium-coupled sulphate, di- and tri-carboxylate transporters"], "Q9BZW8": ["Cell surface interactions at the vascular wall"], "Q9BZX2": ["Pyrimidine salvage"], "Q9BZY9": ["Interferon gamma signaling"], "Q9BZZ2": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "Q9C000": ["The NLRP1 inflammasome"], "Q9C005": ["PKMTs methylate histone lysines", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"], "Q9C026": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q9C030": ["Interferon gamma signaling"], "Q9C035": ["Interferon gamma signaling"], "Q9C037": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q9C040": ["Interferon gamma signaling"], "Q9C075": ["Keratinization", "Formation of the cornified envelope"], "Q9C086": ["UCH proteinases", "DNA Damage Recognition in GG-NER"], "Q9C0B1": ["Reversal of alkylation damage by DNA dioxygenases"], "Q9C0C2": ["Deadenylation of mRNA", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "Q9C0C7": ["Macroautophagy"], "Q9C0C9": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q9C0D9": ["Synthesis of PE"], "Q9C0E4": ["Trafficking of GluR2-containing AMPA receptors"], "Q9C0F3": ["Generic Transcription Pathway"], "Q9C0H2": ["Stimuli-sensing channels"], "Q9C0H5": ["Rho GTPase cycle", "Inactivation of CDC42 and RAC1"], "Q9C0I1": ["Synthesis of PIPs at the early endosome membrane"], "Q9C0I4": ["Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "Q9C0J1": ["Keratan sulfate biosynthesis", "O-linked glycosylation of mucins"], "Q9C0J8": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA Derived from an Intronless Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "Q9C0J9": ["BMAL1:CLOCK,NPAS2 activates circadian gene expression", "Circadian Clock"], "Q9C0K1": ["Zinc influx into cells by the SLC39 gene family"], "Q9C0K7": ["Energy dependent regulation of mTOR by LKB1-AMPK"], "Q9GIY3": ["Downstream TCR signaling", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "MHC class II antigen presentation", "PD-1 signaling", "Interferon gamma signaling"], "Q9GZK3": ["Olfactory Signaling Pathway"], "Q9GZK4": ["Olfactory Signaling Pathway"], "Q9GZK6": ["Olfactory Signaling Pathway"], "Q9GZK7": ["Olfactory Signaling Pathway"], "Q9GZL7": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "Q9GZM6": ["Olfactory Signaling Pathway"], "Q9GZM8": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "Q9GZN2": ["Downregulation of SMAD2/3:SMAD4 transcriptional activity", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription"], "Q9GZP0": ["Signaling by PDGF"], "Q9GZP9": ["ABC-family proteins mediated transport", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Defective CFTR causes cystic fibrosis", "ER Quality Control Compartment (ERQC)"], "Q9GZQ3": ["Neddylation"], "Q9GZQ4": ["Peptide ligand-binding receptors", "G alpha (q) signalling events", "G alpha (i) signalling events"], "Q9GZQ6": ["Orexin and neuropeptides FF and QRFP bind to their respective receptors", "G alpha (q) signalling events"], "Q9GZQ8": ["Macroautophagy", "Pink/Parkin Mediated Mitophagy", "TBC/RABGAPs", "Receptor Mediated Mitophagy"], "Q9GZR5": ["Synthesis of very long-chain fatty acyl-CoAs"], "Q9GZS1": ["NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase I Transcription Termination"], "Q9GZS3": ["Formation of RNA Pol II elongation complex ", "mRNA decay by 3' to 5' exoribonuclease", "RNA Polymerase II Pre-transcription Events", "RNA Polymerase II Transcription Elongation", "E3 ubiquitin ligases ubiquitinate target proteins"], "Q9GZS9": ["Keratan sulfate biosynthesis"], "Q9GZT4": ["Serine biosynthesis"], "Q9GZT5": ["WNT ligand biogenesis and trafficking", "WNT ligand biogenesis and trafficking", "Class B/2 (Secretin family receptors)"], "Q9GZT9": ["Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"], "Q9GZU1": ["TRP channels", "Transferrin endocytosis and recycling"], "Q9GZV3": ["Acetylcholine Neurotransmitter Release Cycle", "Transport of bile salts and organic acids, metal ions and amine compounds", "Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A)", "Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A)"], "Q9GZV4": ["Hypusine synthesis from eIF5A-lysine"], "Q9GZV5": ["Signaling by Hippo", "YAP1- and WWTR1 (TAZ)-stimulated gene expression", "YAP1- and WWTR1 (TAZ)-stimulated gene expression", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Physiological factors", "RUNX2 regulates osteoblast differentiation", "RUNX3 regulates YAP1-mediated transcription"], "Q9GZV8": ["Transcriptional regulation of pluripotent stem cells"], "Q9GZV9": ["PI3K Cascade", "PIP3 activates AKT signaling", "Signaling by activated point mutants of FGFR1", "Signaling by activated point mutants of FGFR3", "FGFR4 ligand binding and activation", "FGFR3c ligand binding and activation", "FGFR1c ligand binding and activation", "FGFR1c and Klotho ligand binding and activation", "FGFR2c ligand binding and activation", "FGFR3 mutant receptor activation", "Activated point mutants of FGFR2", "Constitutive Signaling by Aberrant PI3K in Cancer", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Phospholipase C-mediated cascade: FGFR1", "Phospholipase C-mediated cascade; FGFR2", "Phospholipase C-mediated cascade; FGFR3", "Phospholipase C-mediated cascade; FGFR4", "Downstream signaling of activated FGFR1", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "PI-3K cascade:FGFR3", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "PI-3K cascade:FGFR4", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "Signaling by FGFR2 in disease", "Signaling by FGFR1 in disease", "FGFRL1 modulation of FGFR1 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Signaling by FGFR3 point mutants in cancer", "Post-translational protein phosphorylation"], "Q9GZX3": ["Keratan sulfate biosynthesis", "Defective CHST6 causes MCDC1"], "Q9GZX5": ["Generic Transcription Pathway", "SUMOylation of transcription cofactors"], "Q9GZX6": ["Interleukin-20 family signaling"], "Q9GZY0": ["Transport of Mature mRNA derived from an Intron-Containing Transcript"], "Q9GZY6": ["Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization"], "Q9GZZ0": ["Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "Q9GZZ7": ["NCAM1 interactions", "RAF/MAP kinase cascade", "RET signaling"], "Q9GZZ9": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q9H008": ["Purine ribonucleoside monophosphate biosynthesis"], "Q9H013": ["Invadopodia formation"], "Q9H015": ["Organic cation transport"], "Q9H040": ["Translesion Synthesis by POLH"], "Q9H063": ["Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription"], "Q9H074": ["Deadenylation of mRNA"], "Q9H081": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "Q9H082": ["Intra-Golgi traffic", "TBC/RABGAPs", "RAB geranylgeranylation"], "Q9H0A0": ["rRNA modification in the nucleus and cytosol"], "Q9H0A8": ["Neddylation"], "Q9H0B6": ["MHC class II antigen presentation", "RHO GTPases activate KTN1", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "Q9H0B8": ["Neutrophil degranulation"], "Q9H0C5": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q9H0D6": ["Association of TriC/CCT with target proteins during biosynthesis", "Major pathway of rRNA processing in the nucleolus and cytosol"], "Q9H0E2": ["Neutrophil degranulation", "Interleukin-1 signaling"], "Q9H0E3": ["HATs acetylate histones", "NoRC negatively regulates rRNA expression"], "Q9H0E7": ["Ub-specific processing proteases"], "Q9H0E9": ["HATs acetylate histones"], "Q9H0F6": ["Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "Neurexins and neuroligins"], "Q9H0F7": ["BBSome-mediated cargo-targeting to cilium"], "Q9H0H0": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes"], "Q9H0H3": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q9H0H5": ["Rho GTPase cycle", "MHC class II antigen presentation", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "Q9H0L4": ["Cleavage of Growing Transcript in the Termination Region ", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "Q9H0M0": ["Downregulation of ERBB4 signaling", "Stimuli-sensing channels", "Regulation of RUNX2 expression and activity", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q9H0M5": ["Generic Transcription Pathway"], "Q9H0P0-4": ["Pyrimidine catabolism"], "Q9H0Q3": ["Ion homeostasis", "Ion transport by P-type ATPases"], "Q9H0R5": ["Interferon gamma signaling"], "Q9H0R8": ["Macroautophagy"], "Q9H0S4": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "Q9H0T7": ["RAB geranylgeranylation"], "Q9H0U3": ["Asparagine N-linked glycosylation", "Miscellaneous transport and binding events", "Neutrophil degranulation"], "Q9H0U4": ["Golgi Cisternae Pericentriolar Stack Reorganization", "Golgi Cisternae Pericentriolar Stack Reorganization", "COPII-mediated vesicle transport", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "Q9H0U6": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q9H0V9": ["COPII-mediated vesicle transport", "Cargo concentration in the ER"], "Q9H0W5": ["Neddylation"], "Q9H0W8": ["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "Q9H0X9": ["Acyl chain remodelling of PS"], "Q9H0Y0": ["Macroautophagy", "Macroautophagy"], "Q9H115": ["COPII-mediated vesicle transport", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network"], "Q9H156": ["Receptor-type tyrosine-protein phosphatases"], "Q9H160": ["SUMOylation of transcription cofactors", "PI5P Regulates TP53 Acetylation"], "Q9H171": ["ZBP1(DAI) mediated induction of type I IFNs", "IRF3 mediated activation of type 1 IFN", "IRF3 mediated activation of type 1 IFN", "RIP-mediated NFkB activation via ZBP1", "Regulation of innate immune responses to cytosolic DNA"], "Q9H172": ["ABC transporters in lipid homeostasis"], "Q9H195": ["Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)", "Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)", "Defective GALNT12 causes colorectal cancer 1 (CRCS1)", "Dectin-2 family", "O-linked glycosylation of mucins", "Termination of O-glycan biosynthesis"], "Q9H1A4": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q9H1B5": ["A tetrasaccharide linker sequence is required for GAG synthesis"], "Q9H1C0": ["G alpha (q) signalling events", "G alpha (i) signalling events", "Lysosphingolipid and LPA receptors"], "Q9H1C4": ["Trafficking and processing of endosomal TLR", "UNC93B1 deficiency - HSE"], "Q9H1C7": ["Neutrophil degranulation"], "Q9H1D0": ["TRP channels"], "Q9H1D9": ["Cytosolic sensors of pathogen-associated DNA ", "RNA Polymerase III Chain Elongation", "RNA Polymerase III Transcription Termination", "RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "Q9H1E1": ["Antimicrobial peptides"], "Q9H1H9": ["Association of TriC/CCT with target proteins during biosynthesis"], "Q9H1I8": ["ALKBH3 mediated reversal of alkylation damage"], "Q9H1J1": ["Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "Q9H1J1-2": ["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "Q9H1J5": ["TCF dependent signaling in response to WNT", "WNT ligand biogenesis and trafficking", "WNT ligand biogenesis and trafficking", "Class B/2 (Secretin family receptors)", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Disassembly of the destruction complex and recruitment of AXIN to the membrane"], "Q9H1J7": ["WNT ligand biogenesis and trafficking", "WNT ligand biogenesis and trafficking", "PCP/CE pathway", "PCP/CE pathway"], "Q9H1K0": ["Toll Like Receptor 9 (TLR9) Cascade", "Factors involved in megakaryocyte development and platelet production"], "Q9H1K1-1": ["Mitochondrial iron-sulfur cluster biogenesis"], "Q9H1K4": ["Organic anion transporters"], "Q9H1M3": ["Beta defensins", "Defensins"], "Q9H1M4": ["Beta defensins", "Defensins"], "Q9H1N7": ["Transport and synthesis of PAPS", "Transport of nucleotide sugars"], "Q9H1P3": ["Synthesis of bile acids and bile salts"], "Q9H1Y0": ["Macroautophagy", "Macroautophagy", "Pink/Parkin Mediated Mitophagy", "Receptor Mediated Mitophagy", "Negative regulators of DDX58/IFIH1 signaling"], "Q9H1Y3": ["G alpha (i) signalling events", "Opsins"], "Q9H204": ["PPARA activates gene expression", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "Q9H205": ["Olfactory Signaling Pathway"], "Q9H207": ["Olfactory Signaling Pathway"], "Q9H208": ["Olfactory Signaling Pathway"], "Q9H209": ["Olfactory Signaling Pathway"], "Q9H210": ["Olfactory Signaling Pathway"], "Q9H211": ["Activation of E2F1 target genes at G1/S", "CDT1 association with the CDC6:ORC:origin complex", "Assembly of the pre-replicative complex", "Orc1 removal from chromatin", "Activation of the pre-replicative complex"], "Q9H221": ["ABC transporters in lipid homeostasis", "Defective ABCG8 causes gallbladder disease 4 and sitosterolemia", "Defective ABCG5 causes sitosterolemia"], "Q9H222": ["ABC transporters in lipid homeostasis", "Defective ABCG8 causes gallbladder disease 4 and sitosterolemia", "Defective ABCG5 causes sitosterolemia"], "Q9H227": ["Glycosphingolipid metabolism"], "Q9H228": ["G alpha (i) signalling events", "Lysosphingolipid and LPA receptors"], "Q9H237": ["WNT ligand biogenesis and trafficking", "WNT ligand secretion is abrogated by the PORCN inhibitor LGK974"], "Q9H244": ["ADP signalling through P2Y purinoceptor 12", "P2Y receptors", "G alpha (i) signalling events"], "Q9H252": ["Voltage gated Potassium channels"], "Q9H254": ["NCAM signaling for neurite out-growth", "NCAM signaling for neurite out-growth", "Interaction between L1 and Ankyrins", "Interaction between L1 and Ankyrins", "RAF/MAP kinase cascade", "COPI-mediated anterograde transport"], "Q9H255": ["Olfactory Signaling Pathway"], "Q9H257": ["NOD1/2 Signaling Pathway", "CLEC7A (Dectin-1) signaling"], "Q9H293": ["Interleukin-17 signaling"], "Q9H295": ["CREB3 factors activate genes"], "Q9H2A2": ["RA biosynthesis pathway"], "Q9H2A7": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "Q9H2A9": ["Reactions specific to the complex N-glycan synthesis pathway"], "Q9H2B4": ["Transport and synthesis of PAPS", "Multifunctional anion exchangers"], "Q9H2C0": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q9H2C2": ["Cholesterol biosynthesis"], "Q9H2C5": ["Olfactory Signaling Pathway"], "Q9H2C8": ["Olfactory Signaling Pathway"], "Q9H2D1": ["Metabolism of folate and pterines"], "Q9H2E6": ["Other semaphorin interactions"], "Q9H2F3": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of bile acids and bile salts via 24-hydroxycholesterol", "Synthesis of bile acids and bile salts via 27-hydroxycholesterol"], "Q9H2F5": ["HATs acetylate histones", "Transcriptional Regulation by E2F6"], "Q9H2G4": ["XBP1(S) activates chaperone genes"], "Q9H2G9": ["Golgi Cisternae Pericentriolar Stack Reorganization"], "Q9H2H0": ["Negative regulation of TCF-dependent signaling by DVL-interacting proteins"], "Q9H2H8": ["mRNA Splicing - Major Pathway"], "Q9H2H9": ["Astrocytic Glutamate-Glutamine Uptake And Metabolism", "Amino acid transport across the plasma membrane"], "Q9H2J7": ["Amino acid transport across the plasma membrane", "Na+/Cl- dependent neurotransmitter transporters"], "Q9H2K0": ["Mitochondrial translation initiation"], "Q9H2K2": ["TCF dependent signaling in response to WNT", "Degradation of AXIN", "XAV939 inhibits tankyrase, stabilizing AXIN", "Ub-specific processing proteases", "Regulation of PTEN stability and activity"], "Q9H2M3": ["Sulfur amino acid metabolism"], "Q9H2M9": ["COPI-independent Golgi-to-ER retrograde traffic", "RAB GEFs exchange GTP for GDP on RABs"], "Q9H2P9": ["Synthesis of diphthamide-EEF2"], "Q9H2S1": ["Ca2+ activated K+ channels"], "Q9H2U1": ["DEx/H-box helicases activate type I IFN and inflammatory cytokines production "], "Q9H2U2": ["Mitochondrial tRNA aminoacylation", "Pyrophosphate hydrolysis"], "Q9H2W6": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q9H2X6": ["YAP1- and WWTR1 (TAZ)-stimulated gene expression", "SUMOylation of transcription cofactors", "Physiological factors", "Regulation of TP53 Activity through Phosphorylation", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Regulation of MECP2 expression and activity"], "Q9H2X9": ["Cation-coupled Chloride cotransporters"], "Q9H300": ["Processing of SMDT1"], "Q9H310": ["Rhesus glycoproteins mediate ammonium transport."], "Q9H313-3": ["Stimuli-sensing channels"], "Q9H324": ["Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "Q9H334-8": ["Transcriptional regulation of pluripotent stem cells"], "Q9H339": ["Olfactory Signaling Pathway"], "Q9H340": ["Olfactory Signaling Pathway"], "Q9H341": ["Olfactory Signaling Pathway"], "Q9H342": ["Olfactory Signaling Pathway"], "Q9H343": ["Olfactory Signaling Pathway"], "Q9H344": ["Olfactory Signaling Pathway"], "Q9H346": ["Olfactory Signaling Pathway"], "Q9H3D4": ["Activation of PUMA and translocation to mitochondria", "TP53 Regulates Metabolic Genes", "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "TP53 Regulates Transcription of Caspase Activators and Caspases", "TP53 Regulates Transcription of Death Receptors and Ligands", "Regulation of TP53 Activity through Association with Co-factors"], "Q9H3H1": ["tRNA modification in the nucleus and cytosol", "tRNA modification in the mitochondrion"], "Q9H3H5": ["Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2"], "Q9H3K6": ["Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"], "Q9H3L0": ["Cobalamin (Cbl, vitamin B12) transport and metabolism", "Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD"], "Q9H3M0": ["Voltage gated Potassium channels"], "Q9H3M7": ["The NLRP3 inflammasome", "The NLRP3 inflammasome", "Regulation of FOXO transcriptional activity by acetylation"], "Q9H3M9": ["Josephin domain DUBs"], "Q9H3N8": ["Histamine receptors", "G alpha (i) signalling events"], "Q9H3P2": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Abortive elongation of HIV-1 transcript in the absence of Tat", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "RNA Polymerase II Transcription Elongation"], "Q9H3P7": ["Golgi Associated Vesicle Biogenesis"], "Q9H3R0": ["HDMs demethylate histones", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3"], "Q9H3R1": ["HS-GAG biosynthesis"], "Q9H3R2": ["Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)", "Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)", "Defective GALNT12 causes colorectal cancer 1 (CRCS1)", "Dectin-2 family", "O-linked glycosylation of mucins", "Termination of O-glycan biosynthesis"], "Q9H3R5": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Deposition of new CENPA-containing nucleosomes at the centromere", "Mitotic Prometaphase"], "Q9H3S1": ["Other semaphorin interactions"], "Q9H3S4": ["Vitamin B1 (thiamin) metabolism"], "Q9H3S5": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "Q9H3S7": ["Interleukin-37 signaling"], "Q9H3Y6": ["PTK6 Down-Regulation"], "Q9H3Z4": ["Neutrophil degranulation", "GABA synthesis, release, reuptake and degradation"], "Q9H410": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Neutrophil degranulation", "Mitotic Prometaphase"], "Q9H427": ["Phase 4 - resting membrane potential"], "Q9H444": ["Budding and maturation of HIV virion", "Macroautophagy", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "Q9H461": ["Class B/2 (Secretin family receptors)", "Asymmetric localization of PCP proteins", "Regulation of FZD by ubiquitination", "RNF mutants show enhanced WNT signaling and proliferation"], "Q9H469": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q9H477": ["Pentose phosphate pathway"], "Q9H479": ["Gamma carboxylation, hypusine formation and arylsulfatase activation"], "Q9H488": ["Pre-NOTCH Processing in the Endoplasmic Reticulum"], "Q9H490": ["Attachment of GPI anchor to uPAR"], "Q9H492": ["Macroautophagy", "Pink/Parkin Mediated Mitophagy", "Receptor Mediated Mitophagy"], "Q9H4A3": ["Stimuli-sensing channels"], "Q9H4A9": ["Synthesis of Leukotrienes (LT) and Eoxins (EX)", "Aflatoxin activation and detoxification"], "Q9H4B4": ["TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "Regulation of TP53 Activity through Phosphorylation"], "Q9H4B6": ["Signaling by Hippo"], "Q9H4B7": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "Gap junction assembly", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Recruitment of NuMA to mitotic centrosomes", "Prefoldin mediated transfer of substrate to CCT/TriC", "Formation of tubulin folding intermediates by CCT/TriC", "Post-chaperonin tubulin folding pathway", "Recycling pathway of L1", "Recycling pathway of L1", "Hedgehog 'off' state", "Cilium Assembly", "Intraflagellar transport", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "Carboxyterminal post-translational modifications of tubulin", "Carboxyterminal post-translational modifications of tubulin", "Activation of AMPK downstream of NMDARs", "Kinesins"], "Q9H4B8": ["Synthesis of Leukotrienes (LT) and Eoxins (EX)", "Aflatoxin activation and detoxification"], "Q9H4E5": ["Rho GTPase cycle"], "Q9H4F1": ["Sialic acid metabolism", "Termination of O-glycan biosynthesis"], "Q9H4G0": ["Trafficking of AMPA receptors", "Neurexins and neuroligins"], "Q9H4I9": ["Mitochondrial calcium ion transport", "Processing of SMDT1"], "Q9H4L4": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "Q9H4L5": ["Synthesis of bile acids and bile salts"], "Q9H4M3": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q9H4M7": ["Synthesis of PIPs at the plasma membrane"], "Q9H4M9": ["Factors involved in megakaryocyte development and platelet production"], "Q9H4P4": ["Downregulation of ERBB2:ERBB3 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q9H4X1": ["TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "Q9H4Y5": ["Glutathione conjugation", "Vitamin C (ascorbate) metabolism"], "Q9H4Z2": ["Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "Q9H553": ["Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "Defective ALG2 causes ALG2-CDG (CDG-1i)"], "Q9H583": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "Q9H598": ["Transport of inorganic cations/anions and amino acids/oligopeptides", "GABA synthesis, release, reuptake and degradation"], "Q9H5I1": ["PKMTs methylate histone lysines"], "Q9H5J4": ["Activation of gene expression by SREBF (SREBP)", "Synthesis of very long-chain fatty acyl-CoAs"], "Q9H5J8": ["SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase I Transcription Termination"], "Q9H5K3": ["O-linked glycosylation"], "Q9H5Q4": ["Mitochondrial transcription initiation", "Transcriptional activation of mitochondrial biogenesis"], "Q9H5Y7": ["Receptor-type tyrosine-protein phosphatases"], "Q9H633": ["tRNA processing in the nucleus", "Major pathway of rRNA processing in the nucleolus and cytosol"], "Q9H672": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q9H6A0": ["RAB GEFs exchange GTP for GDP on RABs"], "Q9H6D7": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "Q9H6H4": ["Olfactory Signaling Pathway"], "Q9H6I2": ["Deactivation of the beta-catenin transactivating complex"], "Q9H6Q4": ["Cytosolic iron-sulfur cluster assembly"], "Q9H6R3": ["Synthesis of Ketone Bodies"], "Q9H6R4": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "Q9H6T0": ["FGFR2 alternative splicing"], "Q9H6U8": ["Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "Defective ALG9 causes ALG9-CDG (CDG-1l)"], "Q9H6X2-1": ["Uptake and function of anthrax toxins"], "Q9H6X2-2": ["Uptake and function of anthrax toxins"], "Q9H6Z9": ["Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"], "Q9H707": ["Generic Transcription Pathway"], "Q9H765": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q9H772": ["Signaling by BMP"], "Q9H773": ["Interconversion of nucleotide di- and triphosphates"], "Q9H7B4": ["PKMTs methylate histone lysines"], "Q9H7D0": ["Factors involved in megakaryocyte development and platelet production"], "Q9H7L9": ["HDACs deacetylate histones", "NoRC negatively regulates rRNA expression", "Ub-specific processing proteases"], "Q9H7P6": ["Budding and maturation of HIV virion", "Membrane binding and targetting of GAG proteins", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "Q9H7P9": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "Q9H7R0": ["Generic Transcription Pathway"], "Q9H7R5": ["Generic Transcription Pathway"], "Q9H7S9": ["Generic Transcription Pathway"], "Q9H7T0": ["Sperm Motility And Taxes"], "Q9H7X3": ["Generic Transcription Pathway"], "Q9H7X7": ["Intraflagellar transport", "Intraflagellar transport"], "Q9H7Z6": ["HATs acetylate histones"], "Q9H7Z7": ["Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "Neutrophil degranulation"], "Q9H814": ["snRNP Assembly", "RNA polymerase II transcribes snRNA genes"], "Q9H816": ["Fanconi Anemia Pathway"], "Q9H832": ["Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q9H840": ["snRNP Assembly"], "Q9H841": ["Miscellaneous transport and binding events"], "Q9H845": ["Complex I biogenesis"], "Q9H853": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "Gap junction assembly", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Recruitment of NuMA to mitotic centrosomes", "Formation of tubulin folding intermediates by CCT/TriC", "Post-chaperonin tubulin folding pathway", "Recycling pathway of L1", "Recycling pathway of L1", "Cilium Assembly", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "Carboxyterminal post-translational modifications of tubulin", "Carboxyterminal post-translational modifications of tubulin", "Activation of AMPK downstream of NMDARs", "Kinesins"], "Q9H867": ["Protein methylation"], "Q9H8E8": ["HATs acetylate histones"], "Q9H8G1": ["Generic Transcription Pathway"], "Q9H8H0": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "Q9H8H3": ["Neutrophil degranulation"], "Q9H8M1": ["Respiratory electron transport"], "Q9H8M9": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "Q9H8P0": ["Androgen biosynthesis", "Synthesis of Dolichyl-phosphate", "Defective SRD5A3 causes SRD5A3-CDG (CDG-1q) and KHRZ"], "Q9H8S9": ["Signaling by Hippo"], "Q9H8V3": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "Q9H8W5": ["Interferon gamma signaling"], "Q9H8X2": ["Synthesis of pyrophosphates in the cytosol", "Synthesis of IPs in the nucleus"], "Q9H8Y8": ["Golgi Cisternae Pericentriolar Stack Reorganization"], "Q9H900": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "Q9H902": ["Olfactory Signaling Pathway"], "Q9H903": ["Metabolism of folate and pterines"], "Q9H936": ["Organic anion transporters"], "Q9H944": ["PPARA activates gene expression", "Generic Transcription Pathway", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "Q9H963": ["Generic Transcription Pathway"], "Q9H974": ["tRNA modification in the nucleus and cytosol"], "Q9H981": ["UCH proteinases", "DNA Damage Recognition in GG-NER"], "Q9H999": ["Coenzyme A biosynthesis"], "Q9H9A5": ["Deadenylation of mRNA", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "Q9H9A7": ["HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Regulation of TP53 Activity through Phosphorylation", "G2/M DNA damage checkpoint"], "Q9H9B1": ["Senescence-Associated Secretory Phenotype (SASP)", "PKMTs methylate histone lysines", "Regulation of TP53 Activity through Methylation", "Transcriptional Regulation by E2F6"], "Q9H9E3": ["COPI-mediated anterograde transport", "Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network"], "Q9H9F9": ["UCH proteinases", "DNA Damage Recognition in GG-NER"], "Q9H9G7": ["Pre-NOTCH Transcription and Translation", "MicroRNA (miRNA) biogenesis", "Oxidative Stress Induced Senescence", "Oncogene Induced Senescence", "Ca2+ pathway", "Small interfering RNA (siRNA) biogenesis", "Post-transcriptional silencing by small RNAs", "TP53 Regulates Metabolic Genes", "MAPK6/MAPK4 signaling", "Regulation of RUNX1 Expression and Activity", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Regulation of PTEN mRNA translation", "Competing endogenous RNAs (ceRNAs) regulate PTEN translation", "Transcriptional Regulation by MECP2", "Transcriptional Regulation by MECP2", "Estrogen-dependent gene expression", "Regulation of MECP2 expression and activity"], "Q9H9H4": ["Budding and maturation of HIV virion", "Membrane binding and targetting of GAG proteins", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "Q9H9J2": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q9H9J4": ["Ub-specific processing proteases"], "Q9H9L3": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "Q9H9L4": ["HATs acetylate histones"], "Q9H9P5": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q9H9P8": ["Interconversion of 2-oxoglutarate and 2-hydroxyglutarate"], "Q9H9Q2": ["DNA Damage Recognition in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Cargo recognition for clathrin-mediated endocytosis", "Neddylation"], "Q9H9Q4": ["Nonhomologous End-Joining (NHEJ)"], "Q9H9S0": ["POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation", "POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation", "Transcriptional regulation of pluripotent stem cells", "Interleukin-4 and Interleukin-13 signaling"], "Q9H9S3": ["ER-Phagosome pathway", "SRP-dependent cotranslational protein targeting to membrane", "XBP1(S) activates chaperone genes"], "Q9H9S4": ["Energy dependent regulation of mTOR by LKB1-AMPK"], "Q9H9T3": ["HATs acetylate histones"], "Q9H9Y6": ["NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase I Transcription Termination"], "Q9H9Z2": ["Transcriptional regulation of pluripotent stem cells"], "Q9HA47": ["Pyrimidine salvage"], "Q9HA64": ["Gamma carboxylation, hypusine formation and arylsulfatase activation"], "Q9HA65": ["TBC/RABGAPs"], "Q9HA77": ["Mitochondrial tRNA aminoacylation"], "Q9HA82": ["Sphingolipid de novo biosynthesis"], "Q9HAB3": ["Vitamin B2 (riboflavin) metabolism"], "Q9HAB8": ["Coenzyme A biosynthesis"], "Q9HAF1": ["HATs acetylate histones", "HATs acetylate histones", "Regulation of TP53 Activity through Acetylation"], "Q9HAH1": ["Generic Transcription Pathway"], "Q9HAJ7": ["HDACs deacetylate histones", "NoRC negatively regulates rRNA expression"], "Q9HAN9": ["Nicotinate metabolism"], "Q9HAP6": ["Dopamine Neurotransmitter Release Cycle", "RHO GTPases Activate Rhotekin and Rhophilins", "Neurexins and neuroligins"], "Q9HAQ2": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins", "Kinesins"], "Q9HAS3": ["Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"], "Q9HAT0": ["RHO GTPases Activate Rhotekin and Rhophilins"], "Q9HAT1": ["COPII-mediated vesicle transport", "Cargo concentration in the ER"], "Q9HAT8": ["Interleukin-1 signaling", "IRAK1 recruits IKK complex", "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation"], "Q9HAU0": ["Synthesis of PIPs at the plasma membrane"], "Q9HAU4": ["Signaling by BMP", "Downregulation of TGF-beta receptor signaling", "Downregulation of TGF-beta receptor signaling", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Hedgehog 'on' state", "Hedgehog 'on' state", "Ub-specific processing proteases", "Regulation of RUNX3 expression and activity", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q9HAU5": ["Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "Q9HAV0": ["Glucagon signaling in metabolic regulation", "G-protein activation", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42"], "Q9HAV4": ["MicroRNA (miRNA) biogenesis"], "Q9HAV5": ["TNFs bind their physiological receptors"], "Q9HAV7": ["Mitochondrial protein import"], "Q9HAW0": ["RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "Q9HAW4": ["Apoptotic cleavage of cellular proteins", "Activation of ATR in response to replication stress", "Ub-specific processing proteases", "Processing of DNA double-strand break ends"], "Q9HAW7": ["Glucuronidation"], "Q9HAW8": ["Glucuronidation"], "Q9HAW9": ["Glucuronidation"], "Q9HAY6": ["Retinoid metabolism and transport"], "Q9HAZ2": ["PKMTs methylate histone lysines"], "Q9HB03": ["Linoleic acid (LA) metabolism", "alpha-linolenic acid (ALA) metabolism", "Synthesis of very long-chain fatty acyl-CoAs"], "Q9HB14": ["Tandem pore domain halothane-inhibited K+ channel (THIK)", "Phase 4 - resting membrane potential"], "Q9HB15": ["Phase 4 - resting membrane potential"], "Q9HB19": ["Synthesis of PIPs at the plasma membrane"], "Q9HB20": ["Synthesis of PIPs at the plasma membrane"], "Q9HB21": ["Synthesis of PIPs at the plasma membrane"], "Q9HB29": ["Interleukin-38 signaling", "Interleukin-36 pathway"], "Q9HB55": ["Miscellaneous substrates", "Xenobiotics"], "Q9HB63": ["Non-integrin membrane-ECM interactions", "Netrin-1 signaling"], "Q9HB65": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes"], "Q9HB75": ["TP53 Regulates Transcription of Caspase Activators and Caspases"], "Q9HB89": ["Peptide ligand-binding receptors", "G alpha (q) signalling events", "G alpha (i) signalling events"], "Q9HB90": ["Macroautophagy", "mTOR signalling", "mTORC1-mediated signalling", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Regulation of PTEN gene transcription"], "Q9HB96": ["Fanconi Anemia Pathway"], "Q9HBA0": ["TRP channels"], "Q9HBA9": ["Amino acid synthesis and interconversion (transamination)"], "Q9HBE4": ["Interleukin-21 signaling"], "Q9HBE5": ["Interleukin-21 signaling"], "Q9HBG4": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "Q9HBG6": ["Hedgehog 'off' state", "Intraflagellar transport"], "Q9HBH0": ["Rho GTPase cycle", "Neutrophil degranulation"], "Q9HBH5": ["RA biosynthesis pathway"], "Q9HBI1": ["Cell-extracellular matrix interactions", "Regulation of cytoskeletal remodeling and cell spreading by IPP complex components"], "Q9HBI6": ["Fatty acids", "Miscellaneous substrates", "Eicosanoids", "Synthesis of Leukotrienes (LT) and Eoxins (EX)"], "Q9HBJ8": ["Insulin processing"], "Q9HBK9": ["Methylation"], "Q9HBL8": ["Urea cycle"], "Q9HBM1": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "Q9HBM6": ["HIV Transcription Initiation", "RNA Polymerase II HIV Promoter Escape", "Transcription of the HIV genome", "Ub-specific processing proteases", "RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "Q9HBT7": ["Generic Transcription Pathway"], "Q9HBT8": ["Generic Transcription Pathway"], "Q9HBU6": ["Synthesis of PE"], "Q9HBW0": ["G alpha (q) signalling events", "G alpha (i) signalling events", "Lysosphingolipid and LPA receptors"], "Q9HBX8": ["Regulation of FZD by ubiquitination"], "Q9HBX9": ["G alpha (s) signalling events", "Relaxin receptors"], "Q9HBY0": ["RHO GTPases Activate NADPH Oxidases"], "Q9HBY8": ["Stimuli-sensing channels"], "Q9HBZ2": ["PPARA activates gene expression", "Phase I - Functionalization of compounds", "Endogenous sterols", "Xenobiotics", "Aryl hydrocarbon receptor signalling"], "Q9HC16-1": ["Vif-mediated degradation of APOBEC3G", "APOBEC3G mediated resistance to HIV-1 infection"], "Q9HC16-3": ["Vif-mediated degradation of APOBEC3G", "APOBEC3G mediated resistance to HIV-1 infection"], "Q9HC21": ["Vitamin B1 (thiamin) metabolism"], "Q9HC23": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "Q9HC29": ["NOD1/2 Signaling Pathway", "NOD1/2 Signaling Pathway", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "activated TAK1 mediates p38 MAPK activation", "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "Ovarian tumor domain proteases", "Interleukin-1 signaling"], "Q9HC36": ["rRNA modification in the mitochondrion"], "Q9HC52": ["Oxidative Stress Induced Senescence", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of transcription cofactors", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA methylation proteins", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription"], "Q9HC58": ["Sodium/Calcium exchangers"], "Q9HC62": ["SUMO is proteolytically processed"], "Q9HC73": ["Interleukin-7 signaling", "Interleukin-7 signaling"], "Q9HC77": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "AURKA Activation by TPX2"], "Q9HC84": ["Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)", "Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)", "Defective GALNT12 causes colorectal cancer 1 (CRCS1)", "Dectin-2 family", "O-linked glycosylation of mucins", "Termination of O-glycan biosynthesis"], "Q9HC96": ["Degradation of the extracellular matrix"], "Q9HC97": ["Class A/1 (Rhodopsin-like receptors)"], "Q9HC98": ["Activation of NIMA Kinases NEK9, NEK6, NEK7", "Nuclear Pore Complex (NPC) Disassembly"], "Q9HCB6": ["Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "Q9HCC0": ["Biotin transport and metabolism", "Defective HLCS causes multiple carboxylase deficiency", "Branched-chain amino acid catabolism"], "Q9HCE1": ["Pre-NOTCH Transcription and Translation", "Oxidative Stress Induced Senescence", "Oncogene Induced Senescence", "Ca2+ pathway", "TP53 Regulates Metabolic Genes", "MAPK6/MAPK4 signaling", "Regulation of RUNX1 Expression and Activity", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Regulation of PTEN mRNA translation", "Competing endogenous RNAs (ceRNAs) regulate PTEN translation", "Transcriptional Regulation by MECP2", "Transcriptional Regulation by MECP2", "Estrogen-dependent gene expression", "Regulation of MECP2 expression and activity"], "Q9HCE5": ["Processing of Capped Intron-Containing Pre-mRNA"], "Q9HCE6": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "Q9HCE7": ["Signaling by BMP", "Downregulation of TGF-beta receptor signaling", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "Asymmetric localization of PCP proteins", "Hedgehog 'on' state", "Hedgehog 'on' state", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q9HCE9": ["Stimuli-sensing channels", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "Q9HCF6": ["TRP channels"], "Q9HCG1": ["Generic Transcription Pathway"], "Q9HCG7": ["Glycosphingolipid metabolism"], "Q9HCG8": ["mRNA Splicing - Major Pathway"], "Q9HCI7": ["HATs acetylate histones"], "Q9HCJ0": ["Pre-NOTCH Transcription and Translation", "Oxidative Stress Induced Senescence", "Oncogene Induced Senescence", "Ca2+ pathway", "Post-transcriptional silencing by small RNAs", "TP53 Regulates Metabolic Genes", "MAPK6/MAPK4 signaling", "Regulation of RUNX1 Expression and Activity", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Regulation of PTEN mRNA translation", "Competing endogenous RNAs (ceRNAs) regulate PTEN translation", "Transcriptional Regulation by MECP2", "Transcriptional Regulation by MECP2", "Estrogen-dependent gene expression", "Regulation of MECP2 expression and activity"], "Q9HCJ1": ["Miscellaneous transport and binding events"], "Q9HCK4": ["Signaling by ROBO receptors", "Signaling by ROBO receptors", "Regulation of commissural axon pathfinding by SLIT and ROBO", "Regulation of cortical dendrite branching", "Regulation of expression of SLITs and ROBOs", "ROBO receptors bind AKAP5"], "Q9HCK5": ["Pre-NOTCH Transcription and Translation", "MicroRNA (miRNA) biogenesis", "Oxidative Stress Induced Senescence", "Oncogene Induced Senescence", "Ca2+ pathway", "Small interfering RNA (siRNA) biogenesis", "Post-transcriptional silencing by small RNAs", "TP53 Regulates Metabolic Genes", "MAPK6/MAPK4 signaling", "Regulation of RUNX1 Expression and Activity", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Regulation of PTEN mRNA translation", "Competing endogenous RNAs (ceRNAs) regulate PTEN translation", "Transcriptional Regulation by MECP2", "Transcriptional Regulation by MECP2", "Estrogen-dependent gene expression", "Regulation of MECP2 expression and activity"], "Q9HCK8": ["Deactivation of the beta-catenin transactivating complex"], "Q9HCL2": ["Synthesis of PA", "Activation of gene expression by SREBF (SREBP)", "Triglyceride biosynthesis", "RUNX1 regulates estrogen receptor mediated transcription", "Estrogen-dependent gene expression"], "Q9HCL3": ["Generic Transcription Pathway"], "Q9HCM2": ["Sema3A PAK dependent Axon repulsion", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "CRMPs in Sema3A signaling", "CRMPs in Sema3A signaling", "Other semaphorin interactions", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes"], "Q9HCM3": ["Signaling by BRAF and RAF fusions"], "Q9HCM4": ["Neurexins and neuroligins"], "Q9HCM9": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q9HCN2": ["TP53 Regulates Transcription of Genes Involved in Cytochrome C Release"], "Q9HCN6": ["GPVI-mediated activation cascade", "Cell surface interactions at the vascular wall", "Platelet Adhesion to exposed collagen"], "Q9HCQ5": ["O-linked glycosylation of mucins"], "Q9HCR9": ["cGMP effects", "G alpha (s) signalling events"], "Q9HCS2": ["Fatty acids", "Eicosanoids"], "Q9HCS4": ["Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "Deactivation of the beta-catenin transactivating complex", "Ca2+ pathway", "Binding of TCF/LEF:CTNNB1 to target gene promoters", "Repression of WNT target genes", "Repression of WNT target genes", "RUNX3 regulates WNT signaling"], "Q9HCS7": ["Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "mRNA Splicing - Major Pathway"], "Q9HCT0": ["PI3K Cascade", "PIP3 activates AKT signaling", "FGFR1b ligand binding and activation", "FGFR2b ligand binding and activation", "Activated point mutants of FGFR2", "Constitutive Signaling by Aberrant PI3K in Cancer", "Phospholipase C-mediated cascade: FGFR1", "Phospholipase C-mediated cascade; FGFR2", "Downstream signaling of activated FGFR1", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Signaling by FGFR2 in disease", "FGFRL1 modulation of FGFR1 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "Q9HCU5": ["COPII-mediated vesicle transport", "XBP1(S) activates chaperone genes", "Cargo concentration in the ER"], "Q9HCU8": ["Recognition of DNA damage by PCNA-containing replication complex", "Polymerase switching on the C-strand of the telomere", "Processive synthesis on the C-strand of the telomere", "Telomere C-strand (Lagging Strand) Synthesis", "Removal of the Flap Intermediate from the C-strand", "Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "PCNA-Dependent Long Patch Base Excision Repair", "Termination of translesion DNA synthesis", "HDR through Homologous Recombination (HRR)", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Polymerase switching", "Removal of the Flap Intermediate", "Processive synthesis on the lagging strand"], "Q9HCU9": ["HDACs deacetylate histones"], "Q9HCX3": ["Generic Transcription Pathway"], "Q9HCX4": ["Effects of PIP2 hydrolysis", "Elevation of cytosolic Ca2+ levels", "TRP channels", "Role of second messengers in netrin-1 signaling"], "Q9HCZ1": ["Generic Transcription Pathway"], "Q9HD20": ["Ion transport by P-type ATPases"], "Q9HD23": ["Miscellaneous transport and binding events"], "Q9HD26": ["RHO GTPases regulate CFTR trafficking"], "Q9HD33": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q9HD34": ["Mitochondrial iron-sulfur cluster biogenesis"], "Q9HD40": ["Selenocysteine synthesis"], "Q9HD47": ["Phase 0 - rapid depolarisation"], "Q9HD67": ["Regulation of actin dynamics for phagocytic cup formation", "Netrin-1 signaling"], "Q9HD89": ["Neutrophil degranulation", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes"], "Q9HDB5": ["Neurexins and neuroligins", "Neurexins and neuroligins"], "Q9HDD0": ["Acyl chain remodelling of PE"], "Q9LBS8": ["Toxicity of botulinum toxin type B (BoNT/B)", "Toxicity of botulinum toxin type A (BoNT/A)", "Toxicity of botulinum toxin type E (BoNT/E)"], "Q9MY60": ["E3 ubiquitin ligases ubiquitinate target proteins"], "Q9NNW7": ["Detoxification of Reactive Oxygen Species"], "Q9NNX6": ["CD209 (DC-SIGN) signaling", "Butyrophilin (BTN) family interactions"], "Q9NP31": ["VEGFA-VEGFR2 Pathway"], "Q9NP55": ["Antimicrobial peptides"], "Q9NP56": ["G alpha (s) signalling events"], "Q9NP58": ["Mitochondrial ABC transporters", "Defective ABCB6 causes isolated colobomatous microphthalmia 7 (MCOPCB7)"], "Q9NP59": ["Metal ion SLC transporters", "Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages)", "Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum)", "Iron uptake and transport"], "Q9NP60": ["Receptor-type tyrosine-protein phosphatases"], "Q9NP61": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "Q9NP70": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "Q9NP71": ["PKA-mediated phosphorylation of key metabolic factors", "PKA-mediated phosphorylation of key metabolic factors", "AMPK inhibits chREBP transcriptional activation activity", "ChREBP activates metabolic gene expression", "ChREBP activates metabolic gene expression", "PP2A-mediated dephosphorylation of key metabolic factors"], "Q9NP72": ["Neutrophil degranulation", "COPI-independent Golgi-to-ER retrograde traffic", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "Q9NP73": ["Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)"], "Q9NP77": ["RNA polymerase II transcribes snRNA genes"], "Q9NP78": ["ABC-family proteins mediated transport"], "Q9NP79": ["Budding and maturation of HIV virion", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "Q9NP80": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PE"], "Q9NP81": ["Mitochondrial tRNA aminoacylation"], "Q9NP84": ["TNFR2 non-canonical NF-kB pathway", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "Q9NP85": ["Nephrin family interactions"], "Q9NP87": ["Nonhomologous End-Joining (NHEJ)"], "Q9NP90": ["Neutrophil degranulation", "Retrograde transport at the Trans-Golgi-Network", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "Q9NP91": ["Amino acid transport across the plasma membrane", "Na+/Cl- dependent neurotransmitter transporters", "Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)", "Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)"], "Q9NP92": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q9NP94": ["Zinc influx into cells by the SLC39 gene family"], "Q9NP95": ["PI3K Cascade", "PIP3 activates AKT signaling", "Signaling by activated point mutants of FGFR1", "Signaling by activated point mutants of FGFR3", "FGFR4 ligand binding and activation", "FGFR3b ligand binding and activation", "FGFR3c ligand binding and activation", "FGFR1c ligand binding and activation", "FGFR2c ligand binding and activation", "FGFR3 mutant receptor activation", "Activated point mutants of FGFR2", "Constitutive Signaling by Aberrant PI3K in Cancer", "Phospholipase C-mediated cascade: FGFR1", "Phospholipase C-mediated cascade; FGFR2", "Phospholipase C-mediated cascade; FGFR3", "Phospholipase C-mediated cascade; FGFR4", "Downstream signaling of activated FGFR1", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "PI-3K cascade:FGFR3", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "PI-3K cascade:FGFR4", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "Signaling by FGFR2 in disease", "Signaling by FGFR1 in disease", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Signaling by FGFR3 point mutants in cancer"], "Q9NP97": ["Intraflagellar transport"], "Q9NP99": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "DAP12 interactions"], "Q9NPA1": ["Ca2+ activated K+ channels", "cGMP effects"], "Q9NPA2": ["Activation of Matrix Metalloproteinases", "Neutrophil degranulation"], "Q9NPA3": ["Import of palmitoyl-CoA into the mitochondrial matrix"], "Q9NPA8": ["HATs acetylate histones"], "Q9NPB1": ["Pyrimidine catabolism"], "Q9NPB6": ["TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "Tight junction interactions", "Asymmetric localization of PCP proteins"], "Q9NPB8": ["Hydrolysis of LPC", "Hydrolysis of LPE"], "Q9NPB9": ["Chemokine receptors bind chemokines"], "Q9NPC1": ["Leukotriene receptors", "G alpha (q) signalling events"], "Q9NPC2": ["TWIK-releated acid-sensitive K+ channel (TASK)", "Phase 4 - resting membrane potential"], "Q9NPD3": ["ATF4 activates genes", "mRNA decay by 3' to 5' exoribonuclease", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "KSRP (KHSRP) binds and destabilizes mRNA", "Major pathway of rRNA processing in the nucleolus and cytosol"], "Q9NPD5": ["Recycling of bile acids and salts", "Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR)", "Transport of organic anions"], "Q9NPD7": ["Post-translational modification: synthesis of GPI-anchored proteins"], "Q9NPD8": ["Fanconi Anemia Pathway", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes"], "Q9NPE3": ["rRNA modification in the nucleus and cytosol"], "Q9NPF0": ["Cobalamin (Cbl, vitamin B12) transport and metabolism", "Defective CD320 causes methylmalonic aciduria"], "Q9NPF2": ["Chondroitin sulfate biosynthesis"], "Q9NPF4": ["tRNA modification in the nucleus and cytosol"], "Q9NPF5": ["HATs acetylate histones"], "Q9NPF7": ["Interleukin-4 and Interleukin-13 signaling", "Interleukin-23 signaling", "Interleukin-23 signaling"], "Q9NPG1": ["Class B/2 (Secretin family receptors)", "Ca2+ pathway", "Ca2+ pathway", "PCP/CE pathway", "PCP/CE pathway", "Asymmetric localization of PCP proteins", "Asymmetric localization of PCP proteins"], "Q9NPG2": ["Intracellular oxygen transport"], "Q9NPG3": ["Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "Q9NPH0": ["Synthesis of PA"], "Q9NPH2": ["Synthesis of IP2, IP, and Ins in the cytosol"], "Q9NPH3-1": ["PIP3 activates AKT signaling", "Receptor-type tyrosine-protein phosphatases", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Interleukin-36 pathway", "Interleukin-33 signaling", "Interleukin-1 signaling"], "Q9NPH5": ["Detoxification of Reactive Oxygen Species"], "Q9NPH9": ["Interleukin-20 family signaling"], "Q9NPI1": ["Regulation of TP53 Activity through Acetylation"], "Q9NPI5": ["Nicotinate metabolism"], "Q9NPI6": ["mRNA decay by 5' to 3' exoribonuclease", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "Q9NPI8": ["Fanconi Anemia Pathway"], "Q9NPI9": ["Activation of G protein gated Potassium channels", "Potassium transport channels", "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "Q9NPJ1": ["BBSome-mediated cargo-targeting to cilium"], "Q9NPJ3": ["Mitochondrial Fatty Acid Beta-Oxidation"], "Q9NPJ4": ["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "Q9NPJ6": ["PPARA activates gene expression", "Generic Transcription Pathway", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "Q9NPL8": ["Complex I biogenesis"], "Q9NPP4": ["TP53 Regulates Transcription of Caspase Activators and Caspases", "The IPAF inflammasome", "The IPAF inflammasome"], "Q9NPY3": ["Neutrophil degranulation"], "Q9NPZ5": ["A tetrasaccharide linker sequence is required for GAG synthesis"], "Q9NQ11": ["Ion transport by P-type ATPases"], "Q9NQ25": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "Q9NQ36": ["Release of Hh-Np from the secreting cell"], "Q9NQ38": ["Formation of the cornified envelope"], "Q9NQ40": ["Vitamin B2 (riboflavin) metabolism"], "Q9NQ48": ["BBSome-mediated cargo-targeting to cilium"], "Q9NQ50": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q9NQ66": ["PLC beta mediated events", "PLC beta mediated events", "Synthesis of IP3 and IP4 in the cytosol", "Acetylcholine regulates insulin secretion", "Acetylcholine regulates insulin secretion", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (q) signalling events", "G beta:gamma signalling through PLC beta", "Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "Presynaptic function of Kainate receptors"], "Q9NQ69": ["Regulation of expression of SLITs and ROBOs"], "Q9NQ76": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "Q9NQ86": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q9NQ87": ["NOTCH1 Intracellular Domain Regulates Transcription", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "NOTCH3 Intracellular Domain Regulates Transcription"], "Q9NQ88": ["TP53 Regulates Metabolic Genes"], "Q9NQ90": ["Stimuli-sensing channels"], "Q9NQ92": ["RMTs methylate histone arginines"], "Q9NQ94": ["mRNA Editing: C to U Conversion", "Formation of the Editosome"], "Q9NQA5": ["TRP channels"], "Q9NQB0": ["Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "Deactivation of the beta-catenin transactivating complex", "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "Ca2+ pathway", "Binding of TCF/LEF:CTNNB1 to target gene promoters", "Repression of WNT target genes", "Repression of WNT target genes", "TCF7L2 mutants don't bind CTBP", "RUNX3 regulates WNT signaling"], "Q9NQC1": ["HATs acetylate histones"], "Q9NQC3": ["Axonal growth inhibition (RHOA activation)"], "Q9NQC7": ["NOD1/2 Signaling Pathway", "TNFR1-induced proapoptotic signaling", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "Ub-specific processing proteases", "Negative regulators of DDX58/IFIH1 signaling"], "Q9NQC8": ["Intraflagellar transport", "Intraflagellar transport"], "Q9NQG5": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes"], "Q9NQG7": ["RAB GEFs exchange GTP for GDP on RABs"], "Q9NQI0": ["PIWI-interacting RNA (piRNA) biogenesis"], "Q9NQL2": ["Macroautophagy", "mTOR signalling", "mTORC1-mediated signalling", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Regulation of PTEN gene transcription"], "Q9NQN1": ["Olfactory Signaling Pathway"], "Q9NQP4": ["Prefoldin mediated transfer of substrate to CCT/TriC"], "Q9NQR1": ["Condensation of Prophase Chromosomes", "PKMTs methylate histone lysines", "Regulation of TP53 Activity through Methylation"], "Q9NQR4": ["Neutrophil degranulation"], "Q9NQR9": ["Gluconeogenesis"], "Q9NQS1": ["Formation of apoptosome", "Regulation of the apoptosome activity"], "Q9NQS3": ["Adherens junctions interactions", "Nectin/Necl trans heterodimerization"], "Q9NQS5": ["G alpha (s) signalling events", "Neutrophil degranulation"], "Q9NQS7": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA replication proteins", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "Q9NQT4": ["ATF4 activates genes", "mRNA decay by 3' to 5' exoribonuclease", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "KSRP (KHSRP) binds and destabilizes mRNA", "Major pathway of rRNA processing in the nucleolus and cytosol"], "Q9NQT5": ["ATF4 activates genes", "mRNA decay by 3' to 5' exoribonuclease", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "KSRP (KHSRP) binds and destabilizes mRNA", "Major pathway of rRNA processing in the nucleolus and cytosol"], "Q9NQT8": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "Q9NQU5": ["Activation of RAC1"], "Q9NQV7": ["PKMTs methylate histone lysines", "Meiotic recombination", "Meiotic recombination"], "Q9NQW5": ["Generic Transcription Pathway"], "Q9NQX3": ["Molybdenum cofactor biosynthesis"], "Q9NQX5": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "Q9NQX6": ["Generic Transcription Pathway"], "Q9NQZ2": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "Q9NQZ5": ["Synthesis of PC", "Synthesis of PC"], "Q9NQZ7": ["Phosphate bond hydrolysis by NTPDase proteins"], "Q9NQZ8": ["Generic Transcription Pathway"], "Q9NR11": ["Generic Transcription Pathway"], "Q9NR12": ["RET signaling"], "Q9NR19": ["Transcriptional activation of mitochondrial biogenesis", "Ethanol oxidation"], "Q9NR28": ["Release of apoptotic factors from the mitochondria", "SMAC (DIABLO) binds to IAPs ", "SMAC (DIABLO) binds to IAPs ", "SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ", "SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ", "SMAC, XIAP-regulated apoptotic response", "Regulation of the apoptosome activity"], "Q9NR30": ["B-WICH complex positively regulates rRNA expression", "Major pathway of rRNA processing in the nucleolus and cytosol"], "Q9NR33": ["Recognition of DNA damage by PCNA-containing replication complex", "Telomere C-strand synthesis initiation", "PCNA-Dependent Long Patch Base Excision Repair", "Termination of translesion DNA synthesis", "HDR through Homologous Recombination (HRR)", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "DNA replication initiation", "Activation of the pre-replicative complex"], "Q9NR34": ["Intra-Golgi traffic", "Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2"], "Q9NR45": ["Sialic acid metabolism"], "Q9NR48": ["PKMTs methylate histone lysines"], "Q9NR50": ["Recycling of eIF2:GDP"], "Q9NR61": ["Activated NOTCH1 Transmits Signal to the Nucleus", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant", "Constitutive Signaling by NOTCH1 HD Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "NOTCH2 Activation and Transmission of Signal to the Nucleus", "NOTCH2 Activation and Transmission of Signal to the Nucleus", "NOTCH3 Activation and Transmission of Signal to the Nucleus", "NOTCH3 Activation and Transmission of Signal to the Nucleus", "NOTCH4 Activation and Transmission of Signal to the Nucleus"], "Q9NR63": ["Vitamins", "RA biosynthesis pathway", "Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA)"], "Q9NR71": ["Glycosphingolipid metabolism"], "Q9NR77": ["Glyoxylate metabolism and glycine degradation"], "Q9NR80": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "Q9NR81": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "Q9NR82": ["Voltage gated Potassium channels"], "Q9NR96": ["PI3K Cascade", "Trafficking and processing of endosomal TLR", "Toll Like Receptor 9 (TLR9) Cascade", "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "MyD88 dependent cascade initiated on endosome"], "Q9NR97": ["Trafficking and processing of endosomal TLR", "Toll Like Receptor 7/8 (TLR7/8) Cascade", "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "MyD88 dependent cascade initiated on endosome"], "Q9NRA0": ["Sphingolipid de novo biosynthesis"], "Q9NRA1-1": ["Signaling by PDGF"], "Q9NRA2": ["Sialic acid metabolism", "Organic anion transporters", "Defective SLC17A5 causes Salla disease (SD) and ISSD"], "Q9NRB3": ["Chondroitin sulfate biosynthesis"], "Q9NRC6": ["NCAM signaling for neurite out-growth", "NCAM signaling for neurite out-growth", "Interaction between L1 and Ankyrins", "Interaction between L1 and Ankyrins", "RAF/MAP kinase cascade", "COPI-mediated anterograde transport"], "Q9NRD1": ["Association of TriC/CCT with target proteins during biosynthesis", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q9NRD5": ["Cell surface interactions at the vascular wall", "Trafficking of GluR2-containing AMPA receptors"], "Q9NRD8": ["Thyroxine biosynthesis"], "Q9NRD9": ["Thyroxine biosynthesis"], "Q9NRF2": ["Factors involved in megakaryocyte development and platelet production"], "Q9NRF2-2": ["Prolactin receptor signaling", "Signaling by Leptin", "Growth hormone receptor signaling"], "Q9NRF8": ["Interconversion of nucleotide di- and triphosphates"], "Q9NRF9": ["Recognition of DNA damage by PCNA-containing replication complex", "Telomere C-strand synthesis initiation", "PCNA-Dependent Long Patch Base Excision Repair", "Termination of translesion DNA synthesis", "HDR through Homologous Recombination (HRR)", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "DNA replication initiation", "Activation of the pre-replicative complex"], "Q9NRG4": ["PKMTs methylate histone lysines", "Regulation of TP53 Activity through Methylation"], "Q9NRG9": ["ISG15 antiviral mechanism", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "tRNA processing in the nucleus"], "Q9NRH3": ["Recruitment of mitotic centrosome proteins and complexes", "Recruitment of NuMA to mitotic centrosomes"], "Q9NRJ3": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "Q9NRJ4": ["Neddylation"], "Q9NRK6": ["Mitochondrial ABC transporters"], "Q9NRM0": ["Cellular hexose transport", "Defective SLC2A9 causes hypouricemia renal 2 (RHUC2)"], "Q9NRM1": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "Q9NRM6": ["Interleukin-17 signaling"], "Q9NRM7": ["Signaling by Hippo"], "Q9NRN7": ["Vitamin B5 (pantothenate) metabolism"], "Q9NRP2": ["Mitochondrial protein import"], "Q9NRR4": ["MicroRNA (miRNA) biogenesis"], "Q9NRR6": ["Synthesis of PIPs at the Golgi membrane", "ARL13B-mediated ciliary trafficking of INPP5E"], "Q9NRV9": ["G alpha (i) signalling events", "Formyl peptide receptors bind formyl peptides and many other ligands"], "Q9NRW1": ["COPI-independent Golgi-to-ER retrograde traffic", "Retrograde transport at the Trans-Golgi-Network", "TBC/RABGAPs", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "Q9NRW3": ["mRNA Editing: C to U Conversion", "Formation of the Editosome"], "Q9NRW7": ["Intra-Golgi traffic", "Factors involved in megakaryocyte development and platelet production"], "Q9NRX1": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "Q9NRX2": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q9NRX5": ["Serine biosynthesis"], "Q9NRY4": ["Rho GTPase cycle", "Sema4D mediated inhibition of cell attachment and migration", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases"], "Q9NRY5": ["Signaling by BRAF and RAF fusions"], "Q9NRZ5": ["Synthesis of PA"], "Q9NRZ7": ["Synthesis of PA", "COPI-independent Golgi-to-ER retrograde traffic"], "Q9NS00": ["O-linked glycosylation of mucins"], "Q9NS15": ["Molecules associated with elastic fibres"], "Q9NS28": ["G alpha (q) signalling events", "G alpha (i) signalling events", "G alpha (i) signalling events"], "Q9NS40": ["Voltage gated Potassium channels"], "Q9NS56": ["SUMOylation of transcription cofactors", "SUMOylation of SUMOylation proteins", "SUMOylation of immune response proteins"], "Q9NS61": ["Phase 1 - inactivation of fast Na+ channels"], "Q9NS62": ["Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "Q9NS67": ["G alpha (s) signalling events"], "Q9NS69": ["Mitochondrial protein import", "Pink/Parkin Mediated Mitophagy"], "Q9NS73": ["HATs acetylate histones"], "Q9NS75": ["Leukotriene receptors", "G alpha (q) signalling events"], "Q9NS82": ["Basigin interactions", "Amino acid transport across the plasma membrane"], "Q9NS84": ["Chondroitin sulfate biosynthesis"], "Q9NS87": ["MHC class II antigen presentation", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins", "Kinesins"], "Q9NS91": ["Recognition of DNA damage by PCNA-containing replication complex", "E3 ubiquitin ligases ubiquitinate target proteins"], "Q9NSA0": ["Organic anion transport"], "Q9NSA1": ["Cellular hexose transport", "Assembly of active LPL and LIPC lipase complexes"], "Q9NSA2": ["Voltage gated Potassium channels", "Phase 1 - inactivation of fast Na+ channels"], "Q9NSA3": ["Deactivation of the beta-catenin transactivating complex"], "Q9NSB2": ["Keratinization", "Formation of the cornified envelope"], "Q9NSB4": ["Keratinization", "Formation of the cornified envelope"], "Q9NSB8": ["Neurexins and neuroligins", "Neurexins and neuroligins"], "Q9NSC2": ["POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation"], "Q9NSC5": ["Neurexins and neuroligins", "Neurexins and neuroligins"], "Q9NSC7": ["Sialic acid metabolism"], "Q9NSD5": ["Na+/Cl- dependent neurotransmitter transporters", "Reuptake of GABA"], "Q9NSD7": ["G alpha (i) signalling events", "Relaxin receptors"], "Q9NSD9": ["Cytosolic tRNA aminoacylation"], "Q9NSE2": ["Interleukin-7 signaling", "Neddylation", "Growth hormone receptor signaling"], "Q9NSE4": ["Mitochondrial tRNA aminoacylation"], "Q9NSI6": ["Interleukin-7 signaling", "Interleukin-7 signaling", "Chromatin modifying enzymes"], "Q9NSK0": ["MHC class II antigen presentation", "RHO GTPases activate KTN1", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "Q9NSP4": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Deposition of new CENPA-containing nucleosomes at the centromere", "Mitotic Prometaphase"], "Q9NST1": ["Acyl chain remodeling of DAG and TAG"], "Q9NSU2": ["Regulation by TREX1", "IRF3-mediated induction of type I IFN"], "Q9NSV4": ["RHO GTPases Activate Formins"], "Q9NSY2": ["Recycling of bile acids and salts"], "Q9NT22": ["Molecules associated with elastic fibres", "Molecules associated with elastic fibres"], "Q9NT62": ["Macroautophagy"], "Q9NT99": ["Receptor-type tyrosine-protein phosphatases"], "Q9NTG7": ["Transcriptional activation of mitochondrial biogenesis", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "Regulation of FOXO transcriptional activity by acetylation"], "Q9NTI2": ["Ion transport by P-type ATPases"], "Q9NTI5": ["Separation of Sister Chromatids", "Establishment of Sister Chromatid Cohesion", "Cohesin Loading onto Chromatin", "Resolution of Sister Chromatid Cohesion"], "Q9NTJ3": ["Condensation of Prophase Chromosomes", "Condensation of Prometaphase Chromosomes", "Condensation of Prometaphase Chromosomes"], "Q9NTJ4": ["Lysosomal oligosaccharide catabolism"], "Q9NTJ5": ["Synthesis of PIPs at the ER membrane", "Synthesis of PIPs at the Golgi membrane"], "Q9NTK5": ["Platelet degranulation "], "Q9NTM9": ["Ion transport by P-type ATPases"], "Q9NTN3": ["Formation of the active cofactor, UDP-glucuronate", "Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD)", "Transport of nucleotide sugars"], "Q9NTQ9": ["Gap junction assembly"], "Q9NTX7": ["TCF dependent signaling in response to WNT", "Degradation of AXIN", "Ub-specific processing proteases", "Regulation of PTEN stability and activity"], "Q9NUB1": ["Ethanol oxidation"], "Q9NUD9": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "Q9NUI1": ["Beta-oxidation of very long chain fatty acids", "Peroxisomal protein import", "Peroxisomal protein import"], "Q9NUJ1": ["Glucuronidation"], "Q9NUN5": ["Cobalamin (Cbl, vitamin B12) transport and metabolism", "Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF"], "Q9NUN7": ["Sphingolipid de novo biosynthesis"], "Q9NUP1": ["Golgi Associated Vesicle Biogenesis"], "Q9NUP7": ["tRNA modification in the nucleus and cytosol"], "Q9NUP9": ["Dopamine Neurotransmitter Release Cycle", "Neurexins and neuroligins"], "Q9NUQ2": ["Synthesis of PA"], "Q9NUQ9": ["Platelet degranulation "], "Q9NUT2": ["Mitochondrial ABC transporters"], "Q9NUV7": ["Sphingolipid de novo biosynthesis"], "Q9NUW8": ["Nonhomologous End-Joining (NHEJ)"], "Q9NUX5": ["Meiotic synapsis", "Packaging Of Telomere Ends", "DNA Damage/Telomere Stress Induced Senescence"], "Q9NUZ1": ["Beta-oxidation of pristanoyl-CoA"], "Q9NV06": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol", "Neddylation"], "Q9NV23": ["Fatty acyl-CoA biosynthesis"], "Q9NV31": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "Q9NV35": ["Phosphate bond hydrolysis by NUDT proteins"], "Q9NV56": ["HATs acetylate histones"], "Q9NV58": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q9NV66": ["Synthesis of wybutosine at G37 of tRNA(Phe)"], "Q9NV70": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Insulin processing", "VxPx cargo-targeting to cilium"], "Q9NV72": ["Generic Transcription Pathway"], "Q9NV88": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes"], "Q9NV96": ["Neutrophil degranulation"], "Q9NVC6": ["PPARA activates gene expression", "Generic Transcription Pathway", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "Q9NVD7": ["Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "Cell-extracellular matrix interactions", "Regulation of cytoskeletal remodeling and cell spreading by IPP complex components"], "Q9NVE7": ["Coenzyme A biosynthesis"], "Q9NVF9": ["Synthesis of PE"], "Q9NVG8": ["TBC/RABGAPs"], "Q9NVH1": ["Cristae formation"], "Q9NVH2": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes"], "Q9NVH6": ["Carnitine synthesis"], "Q9NVI1": ["Fanconi Anemia Pathway", "TP53 Regulates Transcription of DNA Repair Genes"], "Q9NVK5": ["Signaling by cytosolic FGFR1 fusion mutants", "Signaling by FGFR1 in disease"], "Q9NVM4": ["RMTs methylate histone arginines"], "Q9NVM9": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes"], "Q9NVR0": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q9NVR2": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes"], "Q9NVS2": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q9NVS9": ["Vitamins B6 activation to pyridoxal phosphate"], "Q9NVU0": ["Cytosolic sensors of pathogen-associated DNA ", "RNA Polymerase III Chain Elongation", "RNA Polymerase III Transcription Termination", "RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "Q9NVW2": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q9NVX0": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "Q9NVZ3": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "Q9NW08": ["Cytosolic sensors of pathogen-associated DNA ", "RNA Polymerase III Chain Elongation", "RNA Polymerase III Transcription Termination", "RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "Q9NW13": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "Q9NW15": ["Stimuli-sensing channels"], "Q9NW38": ["Fanconi Anemia Pathway"], "Q9NW64": ["mRNA Splicing - Major Pathway"], "Q9NWA0": ["PPARA activates gene expression", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "Q9NWB1": ["MECP2 regulates transcription factors"], "Q9NWB7": ["Hedgehog 'off' state", "Intraflagellar transport", "Intraflagellar transport"], "Q9NWF4": ["Vitamin B2 (riboflavin) metabolism"], "Q9NWF9": ["Negative regulators of DDX58/IFIH1 signaling"], "Q9NWM0-3": ["PAOs oxidise polyamines to amines", "Interconversion of polyamines"], "Q9NWM8": ["XBP1(S) activates chaperone genes"], "Q9NWQ8": ["GAB1 signalosome", "Phosphorylation of CD3 and TCR zeta chains"], "Q9NWR8": ["Mitochondrial calcium ion transport", "Processing of SMDT1"], "Q9NWS9": ["Generic Transcription Pathway"], "Q9NWT6": ["Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha"], "Q9NWT8": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q9NWU5": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q9NWV8": ["Metalloprotease DUBs", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "G2/M DNA damage checkpoint"], "Q9NWW6": ["Nicotinate metabolism"], "Q9NWW9": ["Acyl chain remodelling of PE"], "Q9NWX5": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q9NWX6": ["tRNA modification in the nucleus and cytosol"], "Q9NWZ3": ["PIP3 activates AKT signaling", "MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "IRAK4 deficiency (TLR5)", "IRAK4 deficiency (TLR2/4)", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Interleukin-1 signaling", "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "MyD88 dependent cascade initiated on endosome", "MyD88 cascade initiated on plasma membrane"], "Q9NWZ5": ["Pyrimidine salvage"], "Q9NWZ8": ["snRNP Assembly"], "Q9NX08": ["Neddylation"], "Q9NX09": ["TP53 Regulates Metabolic Genes"], "Q9NX14": ["Respiratory electron transport", "Complex I biogenesis"], "Q9NX20": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q9NX24": ["Telomere Extension By Telomerase", "rRNA modification in the nucleus and cytosol"], "Q9NX46": ["POLB-Dependent Long Patch Base Excision Repair"], "Q9NX57": ["RAB geranylgeranylation"], "Q9NX62": ["Cytosolic sulfonation of small molecules"], "Q9NX63": ["Mitochondrial protein import", "Cristae formation"], "Q9NX65": ["Generic Transcription Pathway"], "Q9NX70": ["PPARA activates gene expression", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "Q9NX74": ["tRNA modification in the nucleus and cytosol"], "Q9NX76": ["Neutrophil degranulation"], "Q9NXA8": ["Transcriptional activation of mitochondrial biogenesis"], "Q9NXB0": ["Hedgehog 'off' state", "Anchoring of the basal body to the plasma membrane"], "Q9NXB9": ["Linoleic acid (LA) metabolism", "alpha-linolenic acid (ALA) metabolism", "Synthesis of very long-chain fatty acyl-CoAs"], "Q9NXD2": ["Synthesis of PIPs at the early endosome membrane"], "Q9NXE4": ["Glycosphingolipid metabolism"], "Q9NXE8": ["mRNA Splicing - Major Pathway"], "Q9NXF1": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "Q9NXF7": ["Neddylation"], "Q9NXG2": ["rRNA modification in the nucleus and cytosol"], "Q9NXH8": ["Platelet degranulation "], "Q9NXH9": ["tRNA modification in the nucleus and cytosol"], "Q9NXK8": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q9NXL2": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events"], "Q9NXR1": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "RHO GTPases Activate Formins", "Mitotic Prometaphase", "AURKA Activation by TPX2"], "Q9NXR7": ["Metalloprotease DUBs", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Processing of DNA double-strand break ends", "G2/M DNA damage checkpoint"], "Q9NXR8": ["HATs acetylate histones"], "Q9NXT0": ["Generic Transcription Pathway"], "Q9NXX6": ["SUMOylation of DNA damage response and repair proteins"], "Q9NY12": ["rRNA modification in the nucleus and cytosol"], "Q9NY15": ["Scavenging by Class H Receptors"], "Q9NY25": ["DAP12 interactions", "Neutrophil degranulation"], "Q9NY26": ["Zinc influx into cells by the SLC39 gene family"], "Q9NY27": ["Processing of DNA double-strand break ends"], "Q9NY28": ["O-linked glycosylation of mucins"], "Q9NY37": ["Stimuli-sensing channels"], "Q9NY46": ["Interaction between L1 and Ankyrins", "Phase 0 - rapid depolarisation"], "Q9NY47": ["Presynaptic depolarization and calcium channel opening", "Adrenaline,noradrenaline inhibits insulin secretion", "Regulation of insulin secretion", "Regulation of insulin secretion", "Phase 0 - rapid depolarisation", "Phase 2 - plateau phase"], "Q9NY59": ["Glycosphingolipid metabolism", "TNFR1-mediated ceramide production"], "Q9NY61": ["NRAGE signals death through JNK"], "Q9NY64": ["Cellular hexose transport", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "Q9NY65": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "Gap junction assembly", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Recruitment of NuMA to mitotic centrosomes", "Formation of tubulin folding intermediates by CCT/TriC", "Post-chaperonin tubulin folding pathway", "Recycling pathway of L1", "Recycling pathway of L1", "Cilium Assembly", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "Carboxyterminal post-translational modifications of tubulin", "Carboxyterminal post-translational modifications of tubulin", "Activation of AMPK downstream of NMDARs", "Kinesins"], "Q9NY72": ["Interaction between L1 and Ankyrins", "Phase 0 - rapid depolarisation"], "Q9NY84": ["Post-translational modification: synthesis of GPI-anchored proteins"], "Q9NY91": ["Cellular hexose transport"], "Q9NY97": ["Keratan sulfate biosynthesis", "O-linked glycosylation of mucins"], "Q9NYA1": ["Sphingolipid de novo biosynthesis", "Association of TriC/CCT with target proteins during biosynthesis", "VEGFR2 mediated cell proliferation"], "Q9NYA4": ["Synthesis of PIPs at the early endosome membrane", "Synthesis of PIPs at the late endosome membrane", "Downregulation of TGF-beta receptor signaling"], "Q9NYB0": ["Meiotic synapsis", "Packaging Of Telomere Ends", "DNA Damage/Telomere Stress Induced Senescence"], "Q9NYB5": ["Transport of organic anions"], "Q9NYB9": ["Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs"], "Q9NYF0": ["Degradation of DVL"], "Q9NYF5": ["Rho GTPase cycle"], "Q9NYG5": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q9NYG8": ["TWIK related potassium channel (TREK)", "Phase 4 - resting membrane potential"], "Q9NYH9": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "Q9NYJ1": ["Mitochondrial protein import"], "Q9NYJ8": ["Nuclear signaling by ERBB4", "Nuclear signaling by ERBB4", "NOD1/2 Signaling Pathway", "Downstream TCR signaling", "FCERI mediated NF-kB activation", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "activated TAK1 mediates p38 MAPK activation", "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "TNFR1-induced NFkappaB signaling pathway", "CLEC7A (Dectin-1) signaling", "TICAM1,TRAF6-dependent induction of TAK1 complex", "Interleukin-1 signaling", "IRAK2 mediated activation of TAK1 complex", "TRAF6-mediated induction of TAK1 complex within TLR4 complex", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"], "Q9NYK1": ["Trafficking and processing of endosomal TLR", "Toll Like Receptor 7/8 (TLR7/8) Cascade", "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "MyD88 dependent cascade initiated on endosome"], "Q9NYK5": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q9NYL5": ["Synthesis of bile acids and bile salts via 24-hydroxycholesterol", "Endogenous sterols"], "Q9NYL9": ["Striated Muscle Contraction"], "Q9NYM4": ["G alpha (s) signalling events"], "Q9NYM9": ["COPI-mediated anterograde transport", "Intra-Golgi traffic"], "Q9NYP7": ["Linoleic acid (LA) metabolism", "alpha-linolenic acid (ALA) metabolism", "Synthesis of very long-chain fatty acyl-CoAs"], "Q9NYP9": ["Deposition of new CENPA-containing nucleosomes at the centromere"], "Q9NYQ3": ["Peroxisomal lipid metabolism", "Peroxisomal protein import", "Peroxisomal protein import"], "Q9NYR8": ["The canonical retinoid cycle in rods (twilight vision)"], "Q9NYR9": ["RIP-mediated NFkB activation via ZBP1", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "TRAF6 mediated NF-kB activation"], "Q9NYS0": ["RIP-mediated NFkB activation via ZBP1", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "TRAF6 mediated NF-kB activation"], "Q9NYS7": ["Neddylation"], "Q9NYT6": ["Generic Transcription Pathway"], "Q9NYU1": ["ER Quality Control Compartment (ERQC)"], "Q9NYU2": ["ER Quality Control Compartment (ERQC)"], "Q9NYV4": ["TP53 Regulates Transcription of DNA Repair Genes"], "Q9NYV6": ["RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape"], "Q9NYV7": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "Q9NYV8": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "Q9NYV9": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "Q9NYW0": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "Q9NYW1": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "Q9NYW2": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "Q9NYW3": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "Q9NYW4": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "Q9NYW5": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "Q9NYW6": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "Q9NYW7": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "Q9NYY1": ["Interleukin-20 family signaling"], "Q9NYY3": ["TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "Q9NYZ2": ["Mitochondrial iron-sulfur cluster biogenesis"], "Q9NYZ3": ["G2/M Checkpoints", "The role of GTSE1 in G2/M progression after G2 checkpoint"], "Q9NYZ4": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "Q9NZ01": ["Synthesis of very long-chain fatty acyl-CoAs"], "Q9NZ08": ["Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "Q9NZ09": ["Budding and maturation of HIV virion", "Membrane binding and targetting of GAG proteins", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "Q9NZ20": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PE", "Acyl chain remodelling of PG"], "Q9NZ32": ["MHC class II antigen presentation", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Neutrophil degranulation", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic"], "Q9NZ42": ["Nuclear signaling by ERBB4", "Regulated proteolysis of p75NTR", "NRIF signals cell death from the nucleus", "Activated NOTCH1 Transmits Signal to the Nucleus", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "NOTCH2 Activation and Transmission of Signal to the Nucleus", "EPH-ephrin mediated repulsion of cells", "NOTCH3 Activation and Transmission of Signal to the Nucleus", "NOTCH4 Activation and Transmission of Signal to the Nucleus", "Noncanonical activation of NOTCH3", "Amyloid fiber formation"], "Q9NZ43": ["COPI-dependent Golgi-to-ER retrograde traffic"], "Q9NZ52": ["TBC/RABGAPs", "MET receptor recycling", "Amyloid fiber formation"], "Q9NZ53": ["Cytosolic sulfonation of small molecules"], "Q9NZ71": ["Cytosolic iron-sulfur cluster assembly", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)"], "Q9NZ94": ["Neurexins and neuroligins", "Neurexins and neuroligins"], "Q9NZB8-1": ["Molybdenum cofactor biosynthesis"], "Q9NZB8-5": ["Molybdenum cofactor biosynthesis"], "Q9NZC2": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "DAP12 interactions", "DAP12 signaling", "DAP12 signaling", "Other semaphorin interactions"], "Q9NZC3": ["Glycerophospholipid catabolism"], "Q9NZC7": ["Nuclear signaling by ERBB4", "Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "Activation of the TFAP2 (AP-2) family of transcription factors"], "Q9NZD2": ["Glycosphingolipid metabolism"], "Q9NZE8": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q9NZF1": ["Neutrophil degranulation"], "Q9NZH6": ["Interleukin-37 signaling", "Interleukin-18 signaling"], "Q9NZH7": ["Interleukin-36 pathway"], "Q9NZH8": ["Interleukin-36 pathway"], "Q9NZI2": ["Phase 1 - inactivation of fast Na+ channels"], "Q9NZI5": ["PPARA activates gene expression"], "Q9NZI8": ["Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA", "MAPK6/MAPK4 signaling"], "Q9NZJ0": ["Recognition of DNA damage by PCNA-containing replication complex", "Neddylation"], "Q9NZJ5": ["PERK regulates gene expression"], "Q9NZJ6": ["Ubiquinol biosynthesis"], "Q9NZJ9": ["Synthesis of pyrophosphates in the cytosol"], "Q9NZK5": ["Surfactant metabolism", "Neutrophil degranulation"], "Q9NZK7": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PS", "Acyl chain remodelling of PE", "Acyl chain remodelling of PI", "Acyl chain remodelling of PG", "Synthesis of PA"], "Q9NZL3": ["Generic Transcription Pathway"], "Q9NZL6": ["PPARA activates gene expression"], "Q9NZL9": ["Methylation", "Ub-specific processing proteases"], "Q9NZM3": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "Q9NZN1": ["Receptor-type tyrosine-protein phosphatases", "Interleukin-38 signaling"], "Q9NZN3": ["Factors involved in megakaryocyte development and platelet production"], "Q9NZN4": ["Factors involved in megakaryocyte development and platelet production"], "Q9NZN5": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events", "Sema4D induced cell migration and growth-cone collapse"], "Q9NZN8": ["Deadenylation of mRNA", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "Q9NZP0": ["Olfactory Signaling Pathway"], "Q9NZP2": ["Olfactory Signaling Pathway"], "Q9NZP5": ["Olfactory Signaling Pathway"], "Q9NZQ3": ["Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs"], "Q9NZQ7": ["PD-1 signaling"], "Q9NZQ8": ["TRP channels"], "Q9NZQ9": ["Striated Muscle Contraction"], "Q9NZR1": ["Striated Muscle Contraction"], "Q9NZS2": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "Q9NZT1": ["Neutrophil degranulation"], "Q9NZU0": ["Signaling by ROBO receptors", "Downstream signaling of activated FGFR1"], "Q9NZU1": ["Downstream signaling of activated FGFR1"], "Q9NZU5": ["Surfactant metabolism"], "Q9NZV6": ["Protein repair"], "Q9NZV7": ["Generic Transcription Pathway"], "Q9NZV8": ["Voltage gated Potassium channels", "Phase 1 - inactivation of fast Na+ channels"], "Q9NZW4": ["ECM proteoglycans"], "Q9NZZ3": ["Budding and maturation of HIV virion", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "Q9P000": ["Neutrophil degranulation", "Neddylation"], "Q9P013": ["mRNA Splicing - Major Pathway"], "Q9P015": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q9P031": ["Surfactant metabolism", "Defective pro-SFTPB causes pulmonary surfactant metabolism dysfunction 1 (SMDP1) and respiratory distress syndrome (RDS)"], "Q9P032": ["Complex I biogenesis"], "Q9P035": ["Synthesis of very long-chain fatty acyl-CoAs"], "Q9P086": ["PPARA activates gene expression", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "Q9P0G3": ["Formation of the cornified envelope"], "Q9P0J0": ["Respiratory electron transport", "Complex I biogenesis"], "Q9P0J1": ["Regulation of pyruvate dehydrogenase (PDH) complex"], "Q9P0J6": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q9P0J7": ["Neutrophil degranulation"], "Q9P0K1": ["LGI-ADAM interactions"], "Q9P0L0": ["Sphingolipid de novo biosynthesis", "Neutrophil degranulation"], "Q9P0L1": ["Generic Transcription Pathway"], "Q9P0M4": ["Interleukin-17 signaling"], "Q9P0M9": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q9P0N5": ["Anchoring of the basal body to the plasma membrane"], "Q9P0N9": ["TBC/RABGAPs"], "Q9P0P0": ["E3 ubiquitin ligases ubiquitinate target proteins"], "Q9P0S2": ["TP53 Regulates Metabolic Genes", "Respiratory electron transport"], "Q9P0S3": ["Sphingolipid de novo biosynthesis"], "Q9P0U1": ["Mitochondrial protein import", "Pink/Parkin Mediated Mitophagy"], "Q9P0U3": ["SUMO is proteolytically processed"], "Q9P0U4": ["XBP1(S) activates chaperone genes"], "Q9P0W2": ["HDACs deacetylate histones", "Factors involved in megakaryocyte development and platelet production"], "Q9P0X4": ["NCAM1 interactions"], "Q9P0Z9": ["Lysine catabolism", "Peroxisomal protein import", "Peroxisomal protein import"], "Q9P104": ["RET signaling"], "Q9P107": ["Rho GTPase cycle"], "Q9P109": ["O-linked glycosylation of mucins"], "Q9P121": ["Post-translational modification: synthesis of GPI-anchored proteins"], "Q9P126": ["GPVI-mediated activation cascade"], "Q9P127": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA 3'-end processing"], "Q9P1A6": ["Neurexins and neuroligins", "Neurexins and neuroligins"], "Q9P1P4": ["Amine ligand-binding receptors", "G alpha (s) signalling events"], "Q9P1P5": ["Amine ligand-binding receptors", "G alpha (s) signalling events"], "Q9P1Q0": ["Retrograde transport at the Trans-Golgi-Network"], "Q9P1Q5": ["Olfactory Signaling Pathway"], "Q9P1U0": ["NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase I Transcription Termination"], "Q9P1W8": ["Cell surface interactions at the vascular wall", "Signal regulatory protein family interactions"], "Q9P1Z3": ["HCN channels"], "Q9P209": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "Q9P212": ["Synthesis of IP3 and IP4 in the cytosol"], "Q9P218": ["Collagen biosynthesis and modifying enzymes", "Collagen chain trimerization"], "Q9P219": ["Negative regulation of TCF-dependent signaling by DVL-interacting proteins"], "Q9P227": ["Rho GTPase cycle"], "Q9P232": ["Post-translational modification: synthesis of GPI-anchored proteins"], "Q9P241": ["Ion transport by P-type ATPases"], "Q9P244": ["Synaptic adhesion-like molecules"], "Q9P255": ["Generic Transcription Pathway"], "Q9P258": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "Q9P267": ["UCH proteinases"], "Q9P272": ["tRNA modification in the nucleus and cytosol"], "Q9P283": ["Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "Q9P286": ["Activation of RAC1"], "Q9P289": ["Apoptotic cleavage of cellular proteins"], "Q9P296": ["Peptide ligand-binding receptors", "Regulation of Complement cascade"], "Q9P299": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "Q9P2D8": ["Stimuli-sensing channels"], "Q9P2E2": ["Intraflagellar transport"], "Q9P2E5": ["Chondroitin sulfate biosynthesis"], "Q9P2F6": ["Rho GTPase cycle"], "Q9P2H3": ["Intraflagellar transport", "Intraflagellar transport"], "Q9P2I0": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA Derived from an Intronless Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "Q9P2J3": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q9P2J5": ["SeMet incorporation into proteins", "Cytosolic tRNA aminoacylation"], "Q9P2J8": ["Generic Transcription Pathway"], "Q9P2J9": ["Regulation of pyruvate dehydrogenase (PDH) complex"], "Q9P2K1": ["Anchoring of the basal body to the plasma membrane"], "Q9P2K6": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q9P2L0": ["Hedgehog 'off' state", "Intraflagellar transport"], "Q9P2M4": ["TBC/RABGAPs"], "Q9P2M7": ["TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)"], "Q9P2N2": ["Rho GTPase cycle"], "Q9P2N4": ["Degradation of the extracellular matrix", "Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "Q9P2N6": ["HATs acetylate histones"], "Q9P2N7": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q9P2P5": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q9P2R7": ["Citric acid cycle (TCA cycle)"], "Q9P2S2": ["Neurexins and neuroligins", "Neurexins and neuroligins"], "Q9P2T1": ["Purine salvage"], "Q9P2U7": ["Glutamate Neurotransmitter Release Cycle", "Organic anion transporters"], "Q9P2U8": ["Organic anion transporters"], "Q9P2W1": ["Meiotic recombination"], "Q9P2W3": ["Glucagon signaling in metabolic regulation", "G-protein activation", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42"], "Q9P2W7": ["A tetrasaccharide linker sequence is required for GAG synthesis"], "Q9P2W9": ["COPI-dependent Golgi-to-ER retrograde traffic"], "Q9P2X0": ["Synthesis of dolichyl-phosphate mannose", "Defective DPM3 causes DPM3-CDG (CDG-1o)"], "Q9P2Y5": ["Macroautophagy"], "Q9TNN7": ["ER-Phagosome pathway", "ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Interferon gamma signaling", "Interferon alpha/beta signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "Q9TQE0": ["Downstream TCR signaling", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "MHC class II antigen presentation", "PD-1 signaling", "Interferon gamma signaling"], "Q9U4X0": ["Cell surface interactions at the vascular wall"], "Q9UBB5": ["NoRC negatively regulates rRNA expression", "RNA Polymerase I Promoter Opening"], "Q9UBB9": ["mRNA Splicing - Major Pathway"], "Q9UBC0": ["Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "Regulation of gene expression in early pancreatic precursor cells"], "Q9UBC2": ["EGFR downregulation", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "Q9UBC3": ["PRC2 methylates histones and DNA", "NoRC negatively regulates rRNA expression", "SUMOylation of DNA methylation proteins", "DNA methylation"], "Q9UBC9": ["Formation of the cornified envelope"], "Q9UBD3": ["Chemokine receptors bind chemokines", "G alpha (q) signalling events"], "Q9UBD5": ["E2F-enabled inhibition of pre-replication complex formation", "Activation of ATR in response to replication stress", "Assembly of the ORC complex at the origin of replication", "CDC6 association with the ORC:origin complex", "CDT1 association with the CDC6:ORC:origin complex", "Assembly of the pre-replicative complex", "Orc1 removal from chromatin", "Activation of the pre-replicative complex"], "Q9UBD6": ["Rhesus glycoproteins mediate ammonium transport."], "Q9UBD9": ["IL-6-type cytokine receptor ligand interactions"], "Q9UBE0": ["SUMO is conjugated to E1 (UBA2:SAE1)", "SUMO is conjugated to E1 (UBA2:SAE1)", "SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "SUMO is transferred from E1 to E2 (UBE2I, UBC9)"], "Q9UBE8": ["Ca2+ pathway"], "Q9UBF2": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "Q9UBF6": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q9UBF8": ["Synthesis of PIPs at the Golgi membrane"], "Q9UBG0": ["Cross-presentation of soluble exogenous antigens (endosomes)", "Cross-presentation of soluble exogenous antigens (endosomes)"], "Q9UBH0": ["Interleukin-36 pathway"], "Q9UBI1": ["Neutrophil degranulation", "Neddylation"], "Q9UBI6": ["Activation of G protein gated Potassium channels", "Glucagon signaling in metabolic regulation", "G-protein activation", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42", "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "Q9UBJ2": ["ABC transporters in lipid homeostasis"], "Q9UBK2": ["PPARA activates gene expression", "Transcriptional activation of mitochondrial biogenesis", "Activation of PPARGC1A (PGC-1alpha) by phosphorylation", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation", "SUMOylation of transcription cofactors", "Circadian Clock", "Circadian Clock", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes"], "Q9UBK5": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "Q9UBK8": ["Methylation", "Sulfur amino acid metabolism", "Cobalamin (Cbl, vitamin B12) transport and metabolism", "Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE", "Defective MTR causes methylmalonic aciduria and homocystinuria type cblG"], "Q9UBK9": ["Transcriptional Regulation by E2F6"], "Q9UBL3": ["Formation of the beta-catenin:TCF transactivating complex", "PKMTs methylate histone lysines", "Deactivation of the beta-catenin transactivating complex", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"], "Q9UBL6": ["Glycerophospholipid biosynthesis"], "Q9UBL9": ["Elevation of cytosolic Ca2+ levels", "Platelet homeostasis"], "Q9UBM1": ["Synthesis of PC"], "Q9UBM4": ["Degradation of the extracellular matrix"], "Q9UBM7": ["Activation of gene expression by SREBF (SREBP)", "Cholesterol biosynthesis via desmosterol", "Cholesterol biosynthesis via lathosterol"], "Q9UBM8": ["N-Glycan antennae elongation"], "Q9UBN1": ["Presynaptic depolarization and calcium channel opening", "Trafficking of AMPA receptors", "Phase 0 - rapid depolarisation", "Phase 2 - plateau phase", "LGI-ADAM interactions"], "Q9UBN4": ["TRP channels", "Role of second messengers in netrin-1 signaling"], "Q9UBN6": ["Cell surface interactions at the vascular wall", "TP53 Regulates Transcription of Death Receptors and Ligands", "TRAIL signaling"], "Q9UBN7": ["NOTCH1 Intracellular Domain Regulates Transcription", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "HSF1 activation", "Cilium Assembly", "Transcriptional regulation by RUNX2", "RUNX2 regulates osteoblast differentiation"], "Q9UBP5": ["NOTCH1 Intracellular Domain Regulates Transcription", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "RUNX2 regulates osteoblast differentiation", "NOTCH3 Intracellular Domain Regulates Transcription", "NOTCH4 Intracellular Domain Regulates Transcription"], "Q9UBP6": ["tRNA modification in the nucleus and cytosol"], "Q9UBQ0": ["WNT ligand biogenesis and trafficking"], "Q9UBQ5": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "Q9UBQ6": ["XBP1(S) activates chaperone genes"], "Q9UBQ7": ["Glyoxylate metabolism and glycine degradation"], "Q9UBR1": ["Pyrimidine catabolism"], "Q9UBR2": ["Metabolism of Angiotensinogen to Angiotensins", "COPII-mediated vesicle transport", "Lysosome Vesicle Biogenesis", "Cargo concentration in the ER", "Neutrophil degranulation"], "Q9UBR4": ["Regulation of expression of SLITs and ROBOs"], "Q9UBS0": ["AKT phosphorylates targets in the nucleus", "Constitutive Signaling by AKT1 E17K in Cancer"], "Q9UBS3": ["XBP1(S) activates chaperone genes"], "Q9UBS4": ["XBP1(S) activates chaperone genes"], "Q9UBS5": ["Activation of G protein gated Potassium channels", "G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)", "GABA B receptor activation", "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "Q9UBS8": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q9UBT2": ["SUMO is conjugated to E1 (UBA2:SAE1)", "SUMO is conjugated to E1 (UBA2:SAE1)", "SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "SUMO is transferred from E1 to E2 (UBE2I, UBC9)"], "Q9UBT3": ["TCF dependent signaling in response to WNT", "Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling"], "Q9UBT6": ["Translesion synthesis by POLK", "Termination of translesion DNA synthesis", "HDR through Homologous Recombination (HRR)", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER"], "Q9UBU2": ["TCF dependent signaling in response to WNT", "Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling"], "Q9UBU3-1": ["Peptide ligand-binding receptors", "G alpha (q) signalling events", "Synthesis, secretion, and deacylation of Ghrelin"], "Q9UBU3-2": ["Synthesis, secretion, and deacylation of Ghrelin"], "Q9UBU7": ["Activation of ATR in response to replication stress", "Activation of the pre-replicative complex"], "Q9UBU8": ["HATs acetylate histones"], "Q9UBU9": ["Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript"], "Q9UBV2": ["Pre-NOTCH Processing in Golgi", "ABC-family proteins mediated transport", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Defective CFTR causes cystic fibrosis", "ER Quality Control Compartment (ERQC)"], "Q9UBV4": ["WNT ligand biogenesis and trafficking", "WNT ligand biogenesis and trafficking", "Class B/2 (Secretin family receptors)"], "Q9UBV7": ["A tetrasaccharide linker sequence is required for GAG synthesis", "Defective B4GALT7 causes EDS, progeroid type"], "Q9UBW5": ["Neutrophil degranulation"], "Q9UBW7": ["Signaling by cytosolic FGFR1 fusion mutants", "Signaling by FGFR1 in disease"], "Q9UBW8": ["DNA Damage Recognition in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Cargo recognition for clathrin-mediated endocytosis", "Neddylation"], "Q9UBX1": ["MHC class II antigen presentation"], "Q9UBX3": ["Sulfide oxidation to sulfate", "Organic anion transporters", "Gluconeogenesis"], "Q9UBX5": ["Elastic fibre formation", "Molecules associated with elastic fibres", "Molecules associated with elastic fibres"], "Q9UBX8": ["Keratan sulfate biosynthesis", "O-linked glycosylation of mucins", "N-Glycan antennae elongation"], "Q9UBY0": ["Sodium/Proton exchangers"], "Q9UBY5": ["G alpha (q) signalling events", "G alpha (i) signalling events", "Lysosphingolipid and LPA receptors"], "Q9UBZ9": ["Translesion synthesis by REV1", "Translesion synthesis by POLK", "Translesion synthesis by POLI", "Termination of translesion DNA synthesis"], "Q9UC06": ["Generic Transcription Pathway"], "Q9UD71": ["DARPP-32 events", "DARPP-32 events"], "Q9UDR5": ["Lysine catabolism"], "Q9UDV6": ["Generic Transcription Pathway"], "Q9UDV7": ["Generic Transcription Pathway"], "Q9UDW1": ["Respiratory electron transport"], "Q9UDW3": ["mRNA Splicing - Minor Pathway"], "Q9UDY2": ["Signaling by Hippo", "Apoptotic cleavage of cell adhesion proteins"], "Q9UDY6": ["Interferon gamma signaling"], "Q9UDY8": ["Activation of NF-kappaB in B cells", "Activation of NF-kappaB in B cells", "Downstream TCR signaling", "FCERI mediated NF-kB activation", "FCERI mediated NF-kB activation", "CLEC7A (Dectin-1) signaling", "CLEC7A/inflammasome pathway"], "Q9UEF7-1": ["PI3K Cascade", "PIP3 activates AKT signaling", "FGFR1c and Klotho ligand binding and activation", "Constitutive Signaling by Aberrant PI3K in Cancer", "Phospholipase C-mediated cascade: FGFR1", "Downstream signaling of activated FGFR1", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "Negative regulation of FGFR1 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "Q9UEF7-2": ["PI3K Cascade", "PIP3 activates AKT signaling", "FGFR1c and Klotho ligand binding and activation", "Constitutive Signaling by Aberrant PI3K in Cancer", "Phospholipase C-mediated cascade: FGFR1", "Downstream signaling of activated FGFR1", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "Negative regulation of FGFR1 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "Q9UER7": ["SUMOylation of transcription cofactors", "Regulation of TP53 Degradation"], "Q9UET6": ["tRNA modification in the nucleus and cytosol"], "Q9UEU0": ["Platelet degranulation "], "Q9UEW3": ["Scavenging by Class A Receptors", "Scavenging by Class A Receptors"], "Q9UEY8": ["Miscellaneous transport and binding events"], "Q9UF02": ["Phase 0 - rapid depolarisation", "Phase 2 - plateau phase"], "Q9UF12": ["Glyoxylate metabolism and glycine degradation", "Proline catabolism"], "Q9UF33": ["EPH-Ephrin signaling", "EPH-Ephrin signaling", "EPHA-mediated growth cone collapse", "EPHA-mediated growth cone collapse", "EPH-ephrin mediated repulsion of cells", "EPH-ephrin mediated repulsion of cells"], "Q9UFF9": ["Deadenylation of mRNA", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "Q9UG01": ["Hedgehog 'off' state", "Intraflagellar transport", "Intraflagellar transport"], "Q9UG56": ["Synthesis of PE"], "Q9UGB7": ["Synthesis of IP2, IP, and Ins in the cytosol"], "Q9UGC6": ["G alpha (q) signalling events", "G alpha (i) signalling events", "G alpha (z) signalling events", "G alpha (z) signalling events"], "Q9UGC7": ["Mitochondrial translation termination"], "Q9UGF5": ["Olfactory Signaling Pathway"], "Q9UGF6": ["Olfactory Signaling Pathway"], "Q9UGF7": ["Olfactory Signaling Pathway"], "Q9UGH3": ["Vitamin C (ascorbate) metabolism"], "Q9UGI0": ["Ovarian tumor domain proteases"], "Q9UGI6": ["Ca2+ activated K+ channels"], "Q9UGI9": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Macroautophagy", "Activation of PPARGC1A (PGC-1alpha) by phosphorylation", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Regulation of TP53 Activity through Phosphorylation", "Activation of AMPK downstream of NMDARs"], "Q9UGJ0": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Macroautophagy", "AMPK inhibits chREBP transcriptional activation activity", "AMPK inhibits chREBP transcriptional activation activity", "Import of palmitoyl-CoA into the mitochondrial matrix", "Activation of PPARGC1A (PGC-1alpha) by phosphorylation", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Regulation of TP53 Activity through Phosphorylation", "Activation of AMPK downstream of NMDARs"], "Q9UGJ1": ["Recruitment of mitotic centrosome proteins and complexes", "Recruitment of NuMA to mitotic centrosomes"], "Q9UGK3": ["PTK6 Activates STAT3"], "Q9UGL1": ["HDMs demethylate histones", "TFAP2 (AP-2) family regulates transcription of cell cycle factors"], "Q9UGM1": ["Highly calcium permeable postsynaptic nicotinic acetylcholine receptors"], "Q9UGM3": ["Surfactant metabolism"], "Q9UGM6": ["Mitochondrial tRNA aminoacylation"], "Q9UGN4": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation"], "Q9UGN5": ["POLB-Dependent Long Patch Base Excision Repair", "HDR through MMEJ (alt-NHEJ)", "DNA Damage Recognition in GG-NER", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER"], "Q9UGP4": ["Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"], "Q9UGP5": ["Nonhomologous End-Joining (NHEJ)"], "Q9UGP8": ["XBP1(S) activates chaperone genes"], "Q9UGQ2": ["Presynaptic depolarization and calcium channel opening"], "Q9UGQ3": ["Cellular hexose transport"], "Q9UGY1": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "Q9UH17": ["mRNA Editing: C to U Conversion", "Formation of the Editosome"], "Q9UH73": ["Transcriptional regulation of white adipocyte differentiation"], "Q9UH77": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q9UH90": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q9UH92": ["ChREBP activates metabolic gene expression", "ChREBP activates metabolic gene expression"], "Q9UH99": ["Meiotic synapsis"], "Q9UHA4": ["Macroautophagy", "mTOR signalling", "mTORC1-mediated signalling", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "MAP2K and MAPK activation", "Neutrophil degranulation", "Regulation of PTEN gene transcription"], "Q9UHA7": ["Interleukin-36 pathway"], "Q9UHB4": ["Cytosolic iron-sulfur cluster assembly"], "Q9UHB7": ["Formation of RNA Pol II elongation complex ", "RNA Polymerase II Pre-transcription Events", "RNA Polymerase II Transcription Elongation"], "Q9UHB9": ["SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane"], "Q9UHC1": ["Meiotic recombination"], "Q9UHC3": ["Stimuli-sensing channels"], "Q9UHC7": ["AKT phosphorylates targets in the cytosol", "Regulation of PTEN stability and activity", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q9UHC9-2": ["Intestinal lipid absorption", "Intestinal lipid absorption"], "Q9UHD0": ["Interleukin-20 family signaling"], "Q9UHD2": ["IRF3 mediated activation of type 1 IFN", "IRF3 mediated activation of type 1 IFN", "Regulation of innate immune responses to cytosolic DNA", "STAT6-mediated induction of chemokines", "IRF3-mediated induction of type I IFN", "Interleukin-37 signaling", "TICAM1-dependent activation of IRF3/IRF7", "TRAF3-dependent IRF activation pathway", "TRAF6 mediated IRF7 activation", "Negative regulators of DDX58/IFIH1 signaling", "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon"], "Q9UHD9": ["Cargo recognition for clathrin-mediated endocytosis"], "Q9UHE5": ["Amyloid fiber formation"], "Q9UHF0": ["Tachykinin receptors bind tachykinins", "G alpha (q) signalling events"], "Q9UHF3": ["Amyloid fiber formation"], "Q9UHF4": ["Interleukin-20 family signaling"], "Q9UHH9": ["Synthesis of IPs in the nucleus", "Interferon alpha/beta signaling"], "Q9UHI5": ["Basigin interactions", "Amino acid transport across the plasma membrane"], "Q9UHI6": ["snRNP Assembly"], "Q9UHI7": ["Vitamin C (ascorbate) metabolism"], "Q9UHI8": ["Degradation of the extracellular matrix", "Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "Q9UHJ6": ["Pentose phosphate pathway"], "Q9UHK6": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of bile acids and bile salts via 24-hydroxycholesterol", "Beta-oxidation of pristanoyl-CoA", "Peroxisomal protein import", "Peroxisomal protein import"], "Q9UHL4": ["Neutrophil degranulation"], "Q9UHM6": ["G alpha (q) signalling events", "Opsins"], "Q9UHN1": ["Transcriptional activation of mitochondrial biogenesis"], "Q9UHP3": ["Ub-specific processing proteases"], "Q9UHP7": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "Q9UHQ9": ["Platelet degranulation ", "Erythrocytes take up carbon dioxide and release oxygen"], "Q9UHR5": ["NoRC negatively regulates rRNA expression"], "Q9UHV7": ["PPARA activates gene expression", "Generic Transcription Pathway", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "Q9UHV9": ["Prefoldin mediated transfer of substrate to CCT/TriC"], "Q9UHW9": ["Cation-coupled Chloride cotransporters", "Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)"], "Q9UHX1": ["mRNA Splicing - Major Pathway"], "Q9UHX3": ["Class B/2 (Secretin family receptors)"], "Q9UHY1": ["Nuclear Receptor transcription pathway"], "Q9UHY7": ["Methionine salvage pathway"], "Q9UI08": ["Generation of second messenger molecules", "Signaling by ROBO receptors", "Signaling by ROBO receptors", "RHO GTPases Activate Formins"], "Q9UI09": ["Respiratory electron transport", "Complex I biogenesis"], "Q9UI10": ["Recycling of eIF2:GDP"], "Q9UI12": ["ROS, RNS production in phagocytes", "Nef Mediated CD4 Down-regulation", "Nef Mediated CD8 Down-regulation", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "Q9UI17": ["Choline catabolism"], "Q9UI30": ["Methylation", "tRNA modification in the nucleus and cytosol", "rRNA modification in the nucleus and cytosol", "Eukaryotic Translation Termination"], "Q9UI32": ["Glutamate Neurotransmitter Release Cycle", "TP53 Regulates Metabolic Genes", "Amino acid synthesis and interconversion (transamination)"], "Q9UI33": ["Interaction between L1 and Ankyrins", "Phase 0 - rapid depolarisation"], "Q9UI40": ["Sodium/Calcium exchangers"], "Q9UI43": ["rRNA modification in the mitochondrion"], "Q9UI95": ["Translesion synthesis by REV1", "Translesion synthesis by POLK", "Translesion synthesis by POLI"], "Q9UIA0": ["Intra-Golgi traffic"], "Q9UIB8": ["Cell surface interactions at the vascular wall"], "Q9UIC8": ["Cyclin A/B1/B2 associated events during G2/M transition"], "Q9UID3": ["Retrograde transport at the Trans-Golgi-Network"], "Q9UIE0": ["Generic Transcription Pathway"], "Q9UIF7-3": ["Recognition and association of DNA glycosylase with site containing an affected purine", "Cleavage of the damaged purine", "Displacement of DNA glycosylase by APEX1", "Defective MUTYH substrate binding", "Defective MUTYH substrate processing"], "Q9UIF7-6": ["Recognition and association of DNA glycosylase with site containing an affected purine", "Cleavage of the damaged purine", "Displacement of DNA glycosylase by APEX1", "Defective MUTYH substrate processing"], "Q9UIF9": ["NoRC negatively regulates rRNA expression"], "Q9UIG0": ["B-WICH complex positively regulates rRNA expression", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"], "Q9UIG8-1": ["Transport of organic anions"], "Q9UIH9": ["BMAL1:CLOCK,NPAS2 activates circadian gene expression"], "Q9UII4": ["ISG15 antiviral mechanism", "DDX58/IFIH1-mediated induction of interferon-alpha/beta", "Negative regulators of DDX58/IFIH1 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q9UIJ5": ["Surfactant metabolism"], "Q9UIJ7": ["Factors involved in megakaryocyte development and platelet production"], "Q9UIK4": ["Caspase activation via Dependence Receptors in the absence of ligand"], "Q9UIL1": ["Retrograde transport at the Trans-Golgi-Network"], "Q9UIL4": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "Q9UIM3": ["The role of GTSE1 in G2/M progression after G2 checkpoint"], "Q9UIQ6": ["Endosomal/Vacuolar pathway", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q9UIR0": ["Butyrophilin (BTN) family interactions"], "Q9UIS9": ["SUMOylation of transcription cofactors"], "Q9UIU0": ["Presynaptic depolarization and calcium channel opening", "Phase 0 - rapid depolarisation", "Phase 2 - plateau phase"], "Q9UIV1": ["Deadenylation of mRNA", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "Q9UIV8": ["RUNX1 regulates transcription of genes involved in differentiation of keratinocytes"], "Q9UIW2": ["Sema3A PAK dependent Axon repulsion", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "CRMPs in Sema3A signaling", "CRMPs in Sema3A signaling", "Other semaphorin interactions"], "Q9UIX4": ["Voltage gated Potassium channels"], "Q9UJ14": ["Glutathione synthesis and recycling", "Aflatoxin activation and detoxification"], "Q9UJ37": ["Sialic acid metabolism", "Termination of O-glycan biosynthesis"], "Q9UJ41": ["TBC/RABGAPs", "RAB GEFs exchange GTP for GDP on RABs"], "Q9UJ68": ["Protein repair"], "Q9UJ70": ["Synthesis of UDP-N-acetyl-glucosamine"], "Q9UJ71": ["Cross-presentation of soluble exogenous antigens (endosomes)", "Cross-presentation of soluble exogenous antigens (endosomes)"], "Q9UJ83": ["Alpha-oxidation of phytanate", "Peroxisomal protein import", "Peroxisomal protein import"], "Q9UJ90": ["Phase 3 - rapid repolarisation", "Phase 2 - plateau phase"], "Q9UJ96": ["Voltage gated Potassium channels", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion"], "Q9UJ98": ["Meiotic synapsis"], "Q9UJA2": ["Acyl chain remodelling of PG", "Synthesis of CL"], "Q9UJA3": ["E2F-enabled inhibition of pre-replication complex formation", "Activation of ATR in response to replication stress", "Unwinding of DNA", "CDC6 association with the ORC:origin complex", "CDT1 association with the CDC6:ORC:origin complex", "Assembly of the pre-replicative complex", "Orc1 removal from chromatin", "Activation of the pre-replicative complex"], "Q9UJA5": ["tRNA modification in the nucleus and cytosol"], "Q9UJF2": ["Regulation of RAS by GAPs", "Signaling by RAS mutants"], "Q9UJK0": ["rRNA modification in the nucleus and cytosol"], "Q9UJL9": ["Generic Transcription Pathway"], "Q9UJM8": ["Glyoxylate metabolism and glycine degradation", "Peroxisomal protein import", "Peroxisomal protein import"], "Q9UJP4": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q9UJQ4": ["POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation", "Transcriptional regulation of pluripotent stem cells", "Regulation of PTEN gene transcription", "Regulation of PTEN gene transcription"], "Q9UJS0": ["Mitochondrial protein import", "Gluconeogenesis"], "Q9UJT9": ["FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q9UJU2": ["Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "Deactivation of the beta-catenin transactivating complex", "Ca2+ pathway", "Binding of TCF/LEF:CTNNB1 to target gene promoters", "Repression of WNT target genes", "Repression of WNT target genes", "RUNX3 regulates WNT signaling"], "Q9UJU3": ["Generic Transcription Pathway"], "Q9UJU5": ["POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation"], "Q9UJU6": ["Caspase-mediated cleavage of cytoskeletal proteins", "Neurexins and neuroligins", "Neutrophil degranulation"], "Q9UJV9": ["STING mediated induction of host immune responses", "Regulation of innate immune responses to cytosolic DNA", "IRF3-mediated induction of type I IFN"], "Q9UJW0": ["MHC class II antigen presentation", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic"], "Q9UJW3": ["DNA methylation"], "Q9UJW8": ["Generic Transcription Pathway"], "Q9UJX2": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q9UJX3": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q9UJX4": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q9UJX5": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q9UJX6": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q9UJY1": ["HSF1-dependent transactivation"], "Q9UJY4": ["TBC/RABGAPs", "Amyloid fiber formation"], "Q9UJY5": ["TBC/RABGAPs", "Amyloid fiber formation"], "Q9UJZ1": ["Processing of SMDT1"], "Q9UK05": ["Signaling by BMP"], "Q9UK08": ["Activation of G protein gated Potassium channels", "Glucagon signaling in metabolic regulation", "G-protein activation", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42", "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "Q9UK10": ["Generic Transcription Pathway"], "Q9UK11": ["Generic Transcription Pathway"], "Q9UK12": ["Generic Transcription Pathway"], "Q9UK13": ["Generic Transcription Pathway"], "Q9UK17": ["Voltage gated Potassium channels", "Phase 1 - inactivation of fast Na+ channels"], "Q9UK22": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q9UK32": ["Recycling pathway of L1", "CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling", "RSK activation", "RSK activation"], "Q9UK39": ["BMAL1:CLOCK,NPAS2 activates circadian gene expression"], "Q9UK41": ["Budding and maturation of HIV virion", "Membrane binding and targetting of GAG proteins", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "Q9UK45": ["mRNA decay by 5' to 3' exoribonuclease", "mRNA decay by 5' to 3' exoribonuclease", "mRNA Splicing - Major Pathway"], "Q9UK55": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "Q9UK73": ["Neddylation"], "Q9UK80": ["TNFR1-induced proapoptotic signaling", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "Ub-specific processing proteases"], "Q9UK96": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q9UK97": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q9UKA1": ["Association of TriC/CCT with target proteins during biosynthesis", "Neddylation", "Iron uptake and transport", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q9UKA2": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q9UKB1": ["Activation of NF-kappaB in B cells", "Downstream TCR signaling", "Regulation of PLK1 Activity at G2/M Transition", "FCERI mediated NF-kB activation", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "NIK-->noncanonical NF-kB signaling", "MAP3K8 (TPL2)-dependent MAPK1/3 activation", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q9UKE5": ["Oxidative Stress Induced Senescence"], "Q9UKF2": ["Interaction With The Zona Pellucida"], "Q9UKF6": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA Derived from an Intronless Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "Q9UKG1": ["Caspase activation via Dependence Receptors in the absence of ligand"], "Q9UKG4": ["Sodium-coupled sulphate, di- and tri-carboxylate transporters"], "Q9UKG9": ["Beta-oxidation of pristanoyl-CoA", "Peroxisomal protein import", "Peroxisomal protein import"], "Q9UKI2": ["MAPK6/MAPK4 signaling"], "Q9UKI3": ["Cell surface interactions at the vascular wall"], "Q9UKJ0": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "Q9UKJ1": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "Q9UKJ8": ["Interaction With The Zona Pellucida"], "Q9UKK3": ["Nicotinamide salvaging"], "Q9UKK6": ["Transport of Mature mRNA derived from an Intron-Containing Transcript"], "Q9UKK9": ["Phosphate bond hydrolysis by NUDT proteins"], "Q9UKL0": ["HDACs deacetylate histones", "Regulation of PTEN gene transcription", "Factors involved in megakaryocyte development and platelet production"], "Q9UKL2": ["Olfactory Signaling Pathway"], "Q9UKL3": ["SUMOylation of transcription cofactors"], "Q9UKL4": ["Electric Transmission Across Gap Junctions", "Gap junction assembly"], "Q9UKL6": ["Synthesis of PC", "Mitochondrial Fatty Acid Beta-Oxidation"], "Q9UKM7": ["Defective MAN1B1 causes MRT15", "ER Quality Control Compartment (ERQC)"], "Q9UKN1": ["Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)", "Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)", "Defective GALNT12 causes colorectal cancer 1 (CRCS1)", "Dectin-2 family", "O-linked glycosylation of mucins", "Termination of O-glycan biosynthesis"], "Q9UKN5": ["p75NTR negatively regulates cell cycle via SC1"], "Q9UKN8": ["RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter"], "Q9UKP4": ["Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "Q9UKP5": ["Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "Q9UKP6": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "Q9UKR0": ["Formation of the cornified envelope"], "Q9UKR3": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Formation of the cornified envelope"], "Q9UKS6": ["Clathrin-mediated endocytosis"], "Q9UKT4": ["SCF-beta-TrCP mediated degradation of Emi1", "Regulation of APC/C activators between G1/S and early anaphase", "Phosphorylation of Emi1", "Activation of E2F1 target genes at G1/S", "Mitotic Metaphase/Anaphase Transition"], "Q9UKT5": ["Association of TriC/CCT with target proteins during biosynthesis", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q9UKT6": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q9UKT7": ["Association of TriC/CCT with target proteins during biosynthesis", "Circadian Clock", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q9UKT8": ["Association of TriC/CCT with target proteins during biosynthesis", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q9UKU0": ["Synthesis of very long-chain fatty acyl-CoAs"], "Q9UKU7": ["Branched-chain amino acid catabolism"], "Q9UKV0": ["NOTCH1 Intracellular Domain Regulates Transcription", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants"], "Q9UKV3": ["Apoptotic cleavage of cellular proteins"], "Q9UKV5": ["N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "ER Quality Control Compartment (ERQC)"], "Q9UKV8": ["Pre-NOTCH Transcription and Translation", "MicroRNA (miRNA) biogenesis", "Ca2+ pathway", "Small interfering RNA (siRNA) biogenesis", "Post-transcriptional silencing by small RNAs", "Transcriptional regulation by small RNAs", "TP53 Regulates Metabolic Genes", "MAPK6/MAPK4 signaling", "Regulation of RUNX1 Expression and Activity", "Regulation of PTEN mRNA translation", "Competing endogenous RNAs (ceRNAs) regulate PTEN translation", "Transcriptional Regulation by MECP2", "Transcriptional Regulation by MECP2", "Estrogen-dependent gene expression", "Regulation of MECP2 expression and activity"], "Q9UKW4": ["GPVI-mediated activation cascade", "GPVI-mediated activation cascade", "NRAGE signals death through JNK", "Rho GTPase cycle", "Regulation of actin dynamics for phagocytic cup formation", "DAP12 signaling", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "FCERI mediated Ca+2 mobilization", "EPH-ephrin mediated repulsion of cells", "G alpha (12/13) signalling events", "VEGFA-VEGFR2 Pathway", "VEGFA-VEGFR2 Pathway", "VEGFR2 mediated vascular permeability"], "Q9UKX2": ["Regulation of actin dynamics for phagocytic cup formation"], "Q9UKX5": ["Integrin cell surface interactions", "Integrin cell surface interactions"], "Q9UKX7": ["ISG15 antiviral mechanism", "Transport of the SLBP independent Mature mRNA", "Transport of the SLBP Dependant Mature mRNA", "Transport of Mature mRNA Derived from an Intronless Transcript", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Rev-mediated nuclear export of HIV RNA", "Transport of Ribonucleoproteins into the Host Nucleus", "NS1 Mediated Effects on Host Pathways", "Viral Messenger RNA Synthesis", "NEP/NS2 Interacts with the Cellular Export Machinery", "Regulation of Glucokinase by Glucokinase Regulatory Protein", "Nuclear import of Rev protein", "Vpr-mediated nuclear import of PICs", "snRNP Assembly", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of ubiquitinylation proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA replication proteins", "Transcriptional regulation by small RNAs", "tRNA processing in the nucleus"], "Q9UKY0": ["Post-translational modification: synthesis of GPI-anchored proteins"], "Q9UKY4": ["Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2", "O-linked glycosylation"], "Q9UKZ1": ["Deadenylation of mRNA", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "Q9UKZ9": ["Collagen biosynthesis and modifying enzymes"], "Q9UL01": ["Dermatan sulfate biosynthesis"], "Q9UL03": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes"], "Q9UL12": ["Choline catabolism"], "Q9UL15": ["Regulation of HSF1-mediated heat shock response"], "Q9UL18": ["Pre-NOTCH Transcription and Translation", "MicroRNA (miRNA) biogenesis", "Oxidative Stress Induced Senescence", "Oncogene Induced Senescence", "Ca2+ pathway", "Small interfering RNA (siRNA) biogenesis", "Post-transcriptional silencing by small RNAs", "Transcriptional regulation by small RNAs", "TP53 Regulates Metabolic Genes", "MAPK6/MAPK4 signaling", "Regulation of RUNX1 Expression and Activity", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Regulation of PTEN mRNA translation", "Competing endogenous RNAs (ceRNAs) regulate PTEN translation", "Transcriptional Regulation by MECP2", "Transcriptional Regulation by MECP2", "Estrogen-dependent gene expression", "Regulation of MECP2 expression and activity"], "Q9UL19": ["Acyl chain remodelling of PE"], "Q9UL25": ["RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "Q9UL26": ["RAB geranylgeranylation"], "Q9UL33": ["COPII-mediated vesicle transport", "RAB GEFs exchange GTP for GDP on RABs"], "Q9UL45": ["Golgi Associated Vesicle Biogenesis"], "Q9UL46": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q9UL51": ["HCN channels"], "Q9UL58": ["Generic Transcription Pathway"], "Q9UL59": ["Generic Transcription Pathway"], "Q9UL62": ["TRP channels", "Role of second messengers in netrin-1 signaling"], "Q9ULB1": ["Non-integrin membrane-ECM interactions", "Neurexins and neuroligins", "Neurexins and neuroligins"], "Q9ULB4": ["Adherens junctions interactions"], "Q9ULB5": ["Adherens junctions interactions"], "Q9ULC3": ["RAB geranylgeranylation"], "Q9ULC5": ["Synthesis of very long-chain fatty acyl-CoAs"], "Q9ULC6": ["Chromatin modifying enzymes"], "Q9ULC8": ["HDL assembly"], "Q9ULD4": ["Platelet degranulation ", "HATs acetylate histones", "Regulation of TP53 Activity through Acetylation"], "Q9ULD5": ["Generic Transcription Pathway"], "Q9ULD6": ["Hedgehog 'off' state"], "Q9ULD8": ["Voltage gated Potassium channels"], "Q9ULE3": ["RAB GEFs exchange GTP for GDP on RABs"], "Q9ULF5": ["Zinc influx into cells by the SLC39 gene family"], "Q9ULG1": ["UCH proteinases", "DNA Damage Recognition in GG-NER"], "Q9ULH0": ["ARMS-mediated activation", "ARMS-mediated activation"], "Q9ULH1": ["VxPx cargo-targeting to cilium", "VxPx cargo-targeting to cilium"], "Q9ULH4": ["Synaptic adhesion-like molecules"], "Q9ULI2": ["Amino acid synthesis and interconversion (transamination)"], "Q9ULI4": ["MHC class II antigen presentation", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "Q9ULK4": ["PPARA activates gene expression", "Generic Transcription Pathway", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "Q9ULK5": ["PCP/CE pathway", "Asymmetric localization of PCP proteins"], "Q9ULL4": ["Other semaphorin interactions"], "Q9ULM2": ["Generic Transcription Pathway"], "Q9ULM3": ["HATs acetylate histones"], "Q9ULM6": ["Deadenylation of mRNA", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "Q9ULP9": ["TBC/RABGAPs"], "Q9ULQ1": ["Stimuli-sensing channels"], "Q9ULR0": ["Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "mRNA Splicing - Major Pathway"], "Q9ULS6": ["Voltage gated Potassium channels"], "Q9ULT6": ["Regulation of FZD by ubiquitination"], "Q9ULT8": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q9ULV0": ["Vasopressin regulates renal water homeostasis via Aquaporins"], "Q9ULV1": ["Class B/2 (Secretin family receptors)", "Ca2+ pathway", "Ca2+ pathway", "Asymmetric localization of PCP proteins", "Regulation of FZD by ubiquitination", "WNT5A-dependent internalization of FZD4", "RNF mutants show enhanced WNT signaling and proliferation", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "Q9ULW0": ["Regulation of TP53 Activity through Phosphorylation", "AURKA Activation by TPX2"], "Q9ULW2": ["Class B/2 (Secretin family receptors)"], "Q9ULW5": ["RAB geranylgeranylation"], "Q9ULW8": ["Chromatin modifying enzymes"], "Q9ULX3": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "Q9ULX7": ["Reversible hydration of carbon dioxide"], "Q9ULX9": ["Factors involved in megakaryocyte development and platelet production", "Factors involved in megakaryocyte development and platelet production"], "Q9ULY5": ["Dectin-2 family", "Dectin-2 family"], "Q9ULZ1": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "Q9ULZ3": ["CLEC7A/inflammasome pathway", "Neutrophil degranulation", "The NLRP3 inflammasome", "The AIM2 inflammasome"], "Q9ULZ9": ["Activation of Matrix Metalloproteinases"], "Q9UM01": ["Basigin interactions", "Amino acid transport across the plasma membrane", "Defective SLC7A7 causes lysinuric protein intolerance (LPI)"], "Q9UM07": ["Chromatin modifying enzymes"], "Q9UM11": ["Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "Phosphorylation of Emi1", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6", "Cyclin A:Cdk2-associated events at S phase entry", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q9UM13": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q9UM21": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation", "N-Glycan antennae elongation"], "Q9UM47": ["Pre-NOTCH Processing in the Endoplasmic Reticulum", "Pre-NOTCH Transcription and Translation", "Pre-NOTCH Processing in Golgi", "Pre-NOTCH Processing in Golgi", "Notch-HLH transcription pathway", "Defective LFNG causes SCDO3", "NOTCH3 Activation and Transmission of Signal to the Nucleus", "NOTCH3 Activation and Transmission of Signal to the Nucleus", "NOTCH3 Intracellular Domain Regulates Transcription", "NOTCH3 Intracellular Domain Regulates Transcription", "Noncanonical activation of NOTCH3"], "Q9UM54": ["Gap junction degradation", "Trafficking of AMPA receptors"], "Q9UM63": ["TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "Q9UMD9": ["Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Assembly of collagen fibrils and other multimeric structures", "Type I hemidesmosome assembly", "Collagen chain trimerization"], "Q9UMF0": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Integrin cell surface interactions"], "Q9UMN6": ["PKMTs methylate histone lysines", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"], "Q9UMQ6": ["Degradation of the extracellular matrix"], "Q9UMR5": ["Fatty acyl-CoA biosynthesis"], "Q9UMR7": ["Dectin-2 family"], "Q9UMS4": ["Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "mRNA Splicing - Major Pathway"], "Q9UMW8": ["ISG15 antiviral mechanism", "Ub-specific processing proteases", "Regulation of IFNA signaling"], "Q9UMX0": ["Cargo recognition for clathrin-mediated endocytosis"], "Q9UMX1": ["Degradation of GLI1 by the proteasome", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'off' state", "Hedgehog 'on' state"], "Q9UMX2": ["Regulation of ornithine decarboxylase (ODC)"], "Q9UMX6": ["Inactivation, recovery and regulation of the phototransduction cascade"], "Q9UMX9": ["Melanin biosynthesis"], "Q9UN19": ["Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "Q9UN37": ["Budding and maturation of HIV virion", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "Q9UN42": ["SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription"], "Q9UN76": ["Amino acid transport across the plasma membrane", "Na+/Cl- dependent neurotransmitter transporters", "Variant SLC6A14 may confer susceptibility towards obesity"], "Q9UN79": ["Deactivation of the beta-catenin transactivating complex"], "Q9UN88": ["GABA A receptor activation", "GABA receptor activation"], "Q9UNA0": ["Degradation of the extracellular matrix", "Degradation of the extracellular matrix", "Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "Q9UNA1": ["Rho GTPase cycle"], "Q9UNA3": ["O-linked glycosylation of mucins"], "Q9UNA4": ["Translesion synthesis by POLI", "Termination of translesion DNA synthesis"], "Q9UNE0": ["TNFs bind their physiological receptors"], "Q9UNE7": ["Downregulation of TGF-beta receptor signaling", "Downregulation of ERBB2 signaling", "Regulation of RUNX2 expression and activity", "Regulation of PTEN stability and activity", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q9UNF0": ["Clathrin-mediated endocytosis"], "Q9UNF1": ["Platelet degranulation "], "Q9UNG2": ["TNFs bind their physiological receptors"], "Q9UNH5": ["Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "MAPK6/MAPK4 signaling"], "Q9UNK4": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PS", "Acyl chain remodelling of PE", "Acyl chain remodelling of PI", "Acyl chain remodelling of PG", "Synthesis of PA"], "Q9UNL2": ["SRP-dependent cotranslational protein targeting to membrane"], "Q9UNL4": ["HATs acetylate histones"], "Q9UNM6": ["Activation of NF-kappaB in B cells", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "ER-Phagosome pathway", "Cross-presentation of soluble exogenous antigens (endosomes)", "Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Vpu mediated degradation of CD4", "Vif-mediated degradation of APOBEC3G", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Separation of Sister Chromatids", "FCERI mediated NF-kB activation", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of ornithine decarboxylase (ODC)", "ABC-family proteins mediated transport", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Asymmetric localization of PCP proteins", "Degradation of AXIN", "Degradation of DVL", "Hedgehog ligand biogenesis", "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'on' state", "Regulation of RAS by GAPs", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "Defective CFTR causes cystic fibrosis", "MAPK6/MAPK4 signaling", "UCH proteinases", "Ub-specific processing proteases", "Neutrophil degranulation", "CDT1 association with the CDC6:ORC:origin complex", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Ubiquitin-dependent degradation of Cyclin D1", "G2/M Checkpoints", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "The role of GTSE1 in G2/M progression after G2 checkpoint", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Regulation of RUNX2 expression and activity", "Regulation of RUNX2 expression and activity", "Regulation of RUNX3 expression and activity", "Regulation of PTEN stability and activity", "Neddylation", "Regulation of expression of SLITs and ROBOs", "Interleukin-1 signaling", "Negative regulation of NOTCH4 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q9UNN8": ["Common Pathway of Fibrin Clot Formation", "Cell surface interactions at the vascular wall"], "Q9UNP4": ["Sialic acid metabolism"], "Q9UNP9": ["Formation of TC-NER Pre-Incision Complex", "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Neutrophil degranulation", "mRNA Splicing - Major Pathway"], "Q9UNQ0": ["Abacavir transmembrane transport", "Iron uptake and transport"], "Q9UNQ2": ["rRNA modification in the nucleus and cytosol"], "Q9UNS1": ["Processing of DNA double-strand break ends"], "Q9UNS2": ["DNA Damage Recognition in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Cargo recognition for clathrin-mediated endocytosis", "Neddylation"], "Q9UNU6": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of bile acids and bile salts via 24-hydroxycholesterol", "Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "Nicotinamide salvaging", "Eicosanoids", "Sterols are 12-hydroxylated by CYP8B1", "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"], "Q9UNW1": ["Synthesis of IPs in the ER lumen"], "Q9UNW8": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (q) signalling events"], "Q9UNX3": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "Q9UNX4": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "Q9UNX9": ["Classical Kir channels", "Phase 4 - resting membrane potential"], "Q9UP38": ["TCF dependent signaling in response to WNT", "Class B/2 (Secretin family receptors)", "PCP/CE pathway", "PCP/CE pathway", "Asymmetric localization of PCP proteins", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Disassembly of the destruction complex and recruitment of AXIN to the membrane"], "Q9UP52": ["Transferrin endocytosis and recycling"], "Q9UP65": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PE", "Acyl chain remodelling of PI", "Hydrolysis of LPC", "Hydrolysis of LPE"], "Q9UP79": ["Degradation of the extracellular matrix", "Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "Q9UP83": ["COPI-mediated anterograde transport", "Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network"], "Q9UP95": ["Cation-coupled Chloride cotransporters"], "Q9UPM8": ["Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis"], "Q9UPM9": ["Anchoring of the basal body to the plasma membrane"], "Q9UPN4": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "Q9UPN7": ["COPII-mediated vesicle transport"], "Q9UPN9": ["Downregulation of SMAD2/3:SMAD4 transcriptional activity"], "Q9UPP1": ["HDMs demethylate histones"], "Q9UPP1-1": ["Condensation of Prophase Chromosomes"], "Q9UPP1-2": ["Condensation of Prophase Chromosomes"], "Q9UPP1-3": ["Condensation of Prophase Chromosomes"], "Q9UPQ4": ["Interferon gamma signaling"], "Q9UPQ8": ["Synthesis of Dolichyl-phosphate", "Defective DOLK causes DOLK-CDG (CDG-1m)"], "Q9UPQ9": ["Pre-NOTCH Transcription and Translation", "Oxidative Stress Induced Senescence", "Oncogene Induced Senescence", "Ca2+ pathway", "Post-transcriptional silencing by small RNAs", "TP53 Regulates Metabolic Genes", "MAPK6/MAPK4 signaling", "Regulation of RUNX1 Expression and Activity", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Regulation of PTEN mRNA translation", "Competing endogenous RNAs (ceRNAs) regulate PTEN translation", "Transcriptional Regulation by MECP2", "Transcriptional Regulation by MECP2", "Estrogen-dependent gene expression", "Regulation of MECP2 expression and activity"], "Q9UPR3": ["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "Q9UPR5": ["Reduction of cytosolic Ca++ levels", "Sodium/Calcium exchangers", "Ion homeostasis"], "Q9UPS6": ["PKMTs methylate histone lysines", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"], "Q9UPT5": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Insulin processing", "VxPx cargo-targeting to cilium"], "Q9UPT9": ["HATs acetylate histones", "Ub-specific processing proteases"], "Q9UPU5": ["Ub-specific processing proteases"], "Q9UPV0": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "Q9UPV9": ["Signaling by BRAF and RAF fusions"], "Q9UPW5": ["Carboxyterminal post-translational modifications of tubulin"], "Q9UPW6": ["SUMOylation of chromatin organization proteins", "RUNX2 regulates osteoblast differentiation"], "Q9UPX8": ["Neurexins and neuroligins", "Neurexins and neuroligins"], "Q9UPY3": ["MicroRNA (miRNA) biogenesis", "Small interfering RNA (siRNA) biogenesis"], "Q9UPY5": ["Basigin interactions", "Amino acid transport across the plasma membrane"], "Q9UPY6": ["Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs"], "Q9UPZ6": ["Defective B3GALTL causes Peters-plus syndrome (PpS)", "O-glycosylation of TSR domain-containing proteins"], "Q9UQ05": ["Voltage gated Potassium channels"], "Q9UQ16": ["Toll Like Receptor 4 (TLR4) Cascade", "Retrograde neurotrophin signalling", "MHC class II antigen presentation", "Recycling pathway of L1", "Clathrin-mediated endocytosis"], "Q9UQ35": ["mRNA Splicing - Major Pathway"], "Q9UQ49": ["Glycosphingolipid metabolism", "Sialic acid metabolism"], "Q9UQ52": ["CHL1 interactions"], "Q9UQ53": ["N-Glycan antennae elongation"], "Q9UQ72": ["Cell surface interactions at the vascular wall"], "Q9UQ74": ["Cell surface interactions at the vascular wall"], "Q9UQ80": ["Neutrophil degranulation"], "Q9UQ84": ["Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Regulation of TP53 Activity through Phosphorylation", "G2/M DNA damage checkpoint"], "Q9UQ88": ["Recruitment of mitotic centrosome proteins and complexes"], "Q9UQ90": ["Processing of SMDT1"], "Q9UQB8": ["Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs"], "Q9UQC2": ["PI3K Cascade", "Signaling by SCF-KIT", "Signaling by cytosolic FGFR1 fusion mutants", "Role of LAT2/NTAL/LAB on calcium mobilization", "Role of LAT2/NTAL/LAB on calcium mobilization", "RET signaling", "Interleukin-15 signaling", "Interleukin receptor SHC signaling"], "Q9UQC9": ["Stimuli-sensing channels"], "Q9UQD0": ["Interaction between L1 and Ankyrins", "Phase 0 - rapid depolarisation"], "Q9UQE7": ["Meiotic synapsis", "Separation of Sister Chromatids", "Establishment of Sister Chromatid Cohesion", "Cohesin Loading onto Chromatin", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA damage response and repair proteins", "Estrogen-dependent gene expression"], "Q9UQK1": ["Glycogen synthesis", "Myoclonic epilepsy of Lafora"], "Q9UQL6": ["NOTCH1 Intracellular Domain Regulates Transcription", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "Regulation of PTEN gene transcription"], "Q9UQM7": ["CaMK IV-mediated phosphorylation of CREB", "HSF1-dependent transactivation", "Trafficking of AMPA receptors", "Ca2+ pathway", "Unblocking of NMDA receptors, glutamate binding and activation", "Phase 0 - rapid depolarisation", "Ion homeostasis", "RAF activation", "Signaling by moderate kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF", "Interferon gamma signaling", "Regulation of MECP2 expression and activity", "Ion transport by P-type ATPases", "Negative regulation of NMDA receptor-mediated neuronal transmission", "Long-term potentiation"], "Q9UQN3": ["Budding and maturation of HIV virion", "Macroautophagy", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "Q9UQP3": ["ECM proteoglycans"], "Q9UQQ2": ["Regulation of KIT signaling", "Factors involved in megakaryocyte development and platelet production"], "Q9Y210": ["Effects of PIP2 hydrolysis", "Elevation of cytosolic Ca2+ levels", "TRP channels", "Role of second messengers in netrin-1 signaling"], "Q9Y216": ["Synthesis of PIPs at the late endosome membrane", "Synthesis of PIPs at the late endosome membrane", "Synthesis of IP2, IP, and Ins in the cytosol"], "Q9Y217": ["Synthesis of PIPs at the plasma membrane"], "Q9Y219": ["Activated NOTCH1 Transmits Signal to the Nucleus", "Activated NOTCH1 Transmits Signal to the Nucleus", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant", "Constitutive Signaling by NOTCH1 HD Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "NOTCH2 Activation and Transmission of Signal to the Nucleus", "NOTCH3 Activation and Transmission of Signal to the Nucleus", "NOTCH3 Activation and Transmission of Signal to the Nucleus"], "Q9Y221": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "Q9Y223": ["Sialic acid metabolism", "Defective GNE causes sialuria, Nonaka myopathy and inclusion body myopathy 2"], "Q9Y224": ["tRNA processing in the nucleus"], "Q9Y226": ["Nicotinamide salvaging"], "Q9Y227": ["Phosphate bond hydrolysis by NTPDase proteins"], "Q9Y230": ["Telomere Extension By Telomerase", "HATs acetylate histones"], "Q9Y233": ["cGMP effects", "G alpha (s) signalling events"], "Q9Y234": ["Glyoxylate metabolism and glycine degradation"], "Q9Y235": ["mRNA Editing: C to U Conversion", "Formation of the Editosome"], "Q9Y239": ["NOD1/2 Signaling Pathway", "NOD1/2 Signaling Pathway", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "activated TAK1 mediates p38 MAPK activation", "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "Ovarian tumor domain proteases", "Interleukin-1 signaling"], "Q9Y241": ["Regulation of gene expression by Hypoxia-inducible Factor"], "Q9Y243": ["Activation of BAD and translocation to mitochondria ", "PIP3 activates AKT signaling", "PIP3 activates AKT signaling", "Downregulation of ERBB2:ERBB3 signaling", "AKT phosphorylates targets in the cytosol", "AKT phosphorylates targets in the cytosol", "AKT phosphorylates targets in the nucleus", "Negative regulation of the PI3K/AKT network", "AKT-mediated inactivation of FOXO1A", "CD28 dependent PI3K/Akt signaling", "CTLA4 inhibitory signaling", "G beta:gamma signalling through PI3Kgamma", "VEGFR2 mediated vascular permeability", "TP53 Regulates Metabolic Genes", "Constitutive Signaling by AKT1 E17K in Cancer", "Regulation of TP53 Degradation", "Regulation of TP53 Activity through Acetylation", "Regulation of TP53 Activity through Association with Co-factors", "Cyclin E associated events during G1/S transition ", "Cyclin A:Cdk2-associated events at S phase entry", "RAB GEFs exchange GTP for GDP on RABs", "RUNX2 regulates genes involved in cell migration", "Regulation of PTEN stability and activity", "Regulation of localization of FOXO transcription factors"], "Q9Y248": ["Unwinding of DNA", "Unwinding of DNA"], "Q9Y251": ["HS-GAG degradation", "Neutrophil degranulation"], "Q9Y252": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q9Y253": ["Translesion Synthesis by POLH", "Termination of translesion DNA synthesis", "HDR through Homologous Recombination (HRR)"], "Q9Y255": ["TP53 Regulates Transcription of Genes Involved in Cytochrome C Release"], "Q9Y256": ["Ub-specific processing proteases"], "Q9Y257": ["Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)", "Phase 4 - resting membrane potential"], "Q9Y259": ["Synthesis of PC", "Synthesis of PE"], "Q9Y261": ["Regulation of gene expression in beta cells"], "Q9Y262": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "Q9Y264": ["Tie2 Signaling"], "Q9Y265": ["Telomere Extension By Telomerase", "Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "HATs acetylate histones", "UCH proteinases", "Ub-specific processing proteases", "DNA Damage Recognition in GG-NER", "Deposition of new CENPA-containing nucleosomes at the centromere"], "Q9Y266": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase", "Mitotic Telophase/Cytokinesis"], "Q9Y271": ["Leukotriene receptors", "G alpha (q) signalling events"], "Q9Y274": ["Pre-NOTCH Processing in Golgi", "Keratan sulfate biosynthesis", "Sialic acid metabolism"], "Q9Y275": ["TNFR2 non-canonical NF-kB pathway", "TNFs bind their physiological receptors", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "Q9Y276": ["Mitochondrial protein import"], "Q9Y277": ["Ub-specific processing proteases", "Mitochondrial calcium ion transport"], "Q9Y278": ["HS-GAG biosynthesis"], "Q9Y285": ["Cytosolic tRNA aminoacylation"], "Q9Y286": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "Q9Y287": ["Amyloid fiber formation"], "Q9Y289": ["Biotin transport and metabolism", "Vitamin B5 (pantothenate) metabolism", "Transport of vitamins, nucleosides, and related molecules"], "Q9Y291": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q9Y294": ["Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "Q9Y296": ["COPII-mediated vesicle transport", "Syndecan interactions", "RAB GEFs exchange GTP for GDP on RABs"], "Q9Y297": ["Activation of NF-kappaB in B cells", "Prolactin receptor signaling", "SCF-beta-TrCP mediated degradation of Emi1", "Vpu mediated degradation of CD4", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of PLK1 Activity at G2/M Transition", "FCERI mediated NF-kB activation", "Deactivation of the beta-catenin transactivating complex", "Circadian Clock", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "Degradation of GLI1 by the proteasome", "Degradation of GLI2 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "NIK-->noncanonical NF-kB signaling", "MAP3K8 (TPL2)-dependent MAPK1/3 activation", "Neddylation", "Interleukin-1 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q9Y2A4": ["Generic Transcription Pathway"], "Q9Y2A7": ["Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs"], "Q9Y2A9": ["Keratan sulfate biosynthesis", "O-linked glycosylation of mucins"], "Q9Y2B2": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "Q9Y2C2": ["Dermatan sulfate biosynthesis"], "Q9Y2C9": ["ER-Phagosome pathway", "MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "Toll Like Receptor TLR6:TLR2 Cascade", "MyD88 deficiency (TLR2/4)", "IRAK4 deficiency (TLR2/4)", "Regulation of TLR by endogenous ligand"], "Q9Y2D0": ["Reversible hydration of carbon dioxide"], "Q9Y2D2": ["Defective SLC35A3 causes arthrogryposis, mental retardation, and seizures (AMRS)", "Transport of nucleotide sugars"], "Q9Y2E5": ["Lysosomal oligosaccharide catabolism"], "Q9Y2E6": ["IRF3 mediated activation of type 1 IFN", "Activated NOTCH1 Transmits Signal to the Nucleus", "Activated NOTCH1 Transmits Signal to the Nucleus", "Regulation of innate immune responses to cytosolic DNA", "IRF3-mediated induction of type I IFN"], "Q9Y2E8": ["Sodium/Proton exchangers"], "Q9Y2F5": ["RNA polymerase II transcribes snRNA genes", "RNA polymerase II transcribes snRNA genes"], "Q9Y2G2": ["Formation of apoptosome", "Regulation of the apoptosome activity"], "Q9Y2G3": ["Neutrophil degranulation", "Ion transport by P-type ATPases"], "Q9Y2G5": ["O-glycosylation of TSR domain-containing proteins"], "Q9Y2G7": ["Generic Transcription Pathway"], "Q9Y2H0": ["Neurexins and neuroligins", "Neurexins and neuroligins"], "Q9Y2H2": ["Synthesis of PIPs at the early endosome membrane"], "Q9Y2H5": ["Synthesis of PIPs at the plasma membrane"], "Q9Y2H8": ["Generic Transcription Pathway"], "Q9Y2I2": ["Post-translational modification: synthesis of GPI-anchored proteins"], "Q9Y2I6": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "Q9Y2I7": ["Synthesis of PIPs at the Golgi membrane", "Synthesis of PIPs at the Golgi membrane", "Synthesis of PIPs at the early endosome membrane", "Synthesis of PIPs at the early endosome membrane", "Synthesis of PIPs at the late endosome membrane", "Synthesis of PIPs at the late endosome membrane"], "Q9Y2J2": ["Neurexins and neuroligins"], "Q9Y2J4": ["Signaling by Hippo"], "Q9Y2J8": ["Chromatin modifying enzymes", "Neutrophil degranulation"], "Q9Y2K6": ["Ub-specific processing proteases"], "Q9Y2K7": ["HDMs demethylate histones"], "Q9Y2L1": ["ATF4 activates genes", "mRNA decay by 3' to 5' exoribonuclease", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "KSRP (KHSRP) binds and destabilizes mRNA", "Major pathway of rRNA processing in the nucleolus and cytosol"], "Q9Y2L5": ["RAB GEFs exchange GTP for GDP on RABs"], "Q9Y2L8": ["Generic Transcription Pathway"], "Q9Y2M0": ["Fanconi Anemia Pathway"], "Q9Y2M5": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q9Y2N7": ["Regulation of gene expression by Hypoxia-inducible Factor", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Transcriptional regulation of pluripotent stem cells", "Neddylation"], "Q9Y2P4": ["Transport of fatty acids"], "Q9Y2P5": ["Recycling of bile acids and salts", "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of bile acids and bile salts via 24-hydroxycholesterol"], "Q9Y2P7": ["Generic Transcription Pathway"], "Q9Y2P8": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "Q9Y2Q0": ["Neutrophil degranulation", "Ion transport by P-type ATPases"], "Q9Y2Q1": ["Generic Transcription Pathway"], "Q9Y2Q3": ["Glutathione conjugation", "Peroxisomal protein import", "Peroxisomal protein import"], "Q9Y2Q5": ["Macroautophagy", "mTOR signalling", "mTORC1-mediated signalling", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "MAP2K and MAPK activation", "Neutrophil degranulation", "Regulation of PTEN gene transcription"], "Q9Y2Q9": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q9Y2R2": ["Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse"], "Q9Y2R4": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "Q9Y2R5": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q9Y2R9": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q9Y2S2": ["Formation of xylulose-5-phosphate"], "Q9Y2T1": ["TCF dependent signaling in response to WNT", "Binding of TCF/LEF:CTNNB1 to target gene promoters", "Degradation of AXIN", "Ub-specific processing proteases"], "Q9Y2T2": ["Association of TriC/CCT with target proteins during biosynthesis"], "Q9Y2T3": ["Purine catabolism"], "Q9Y2T6": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (i) signalling events"], "Q9Y2U2": ["Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)", "Phase 4 - resting membrane potential"], "Q9Y2U8": ["Clearance of Nuclear Envelope Membranes from Chromatin", "Initiation of Nuclear Envelope Reformation", "Depolymerisation of the Nuclear Lamina"], "Q9Y2V7": ["COPI-mediated anterograde transport", "Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network"], "Q9Y2W1": ["PPARA activates gene expression", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "Q9Y2W2": ["mRNA Splicing - Major Pathway"], "Q9Y2W6": ["PIWI-interacting RNA (piRNA) biogenesis"], "Q9Y2W7": ["Phase 1 - inactivation of fast Na+ channels"], "Q9Y2X0": ["PPARA activates gene expression", "Generic Transcription Pathway", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "Q9Y2X3": ["SUMOylation of RNA binding proteins", "rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "Q9Y2X7": ["Ephrin signaling", "Ephrin signaling", "Activation of RAC1 downstream of NMDARs"], "Q9Y2X8": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q9Y2Y0": ["Regulation of insulin secretion"], "Q9Y2Y1": ["Cytosolic sensors of pathogen-associated DNA ", "RNA Polymerase III Chain Elongation", "RNA Polymerase III Transcription Termination", "RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "Q9Y2Y4": ["Recognition of DNA damage by PCNA-containing replication complex"], "Q9Y2Y8": ["Neutrophil degranulation"], "Q9Y2Z0": ["The NLRP3 inflammasome"], "Q9Y2Z2": ["tRNA modification in the mitochondrion"], "Q9Y2Z4": ["Mitochondrial tRNA aminoacylation"], "Q9Y2Z9": ["Ubiquinol biosynthesis"], "Q9Y303": ["Synthesis of UDP-N-acetyl-glucosamine"], "Q9Y305": ["Mitochondrial Fatty Acid Beta-Oxidation"], "Q9Y314": ["NOSIP mediated eNOS trafficking"], "Q9Y315": ["Neutrophil degranulation", "Pentose phosphate pathway"], "Q9Y316": ["ERBB2 Regulates Cell Motility"], "Q9Y324": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "Q9Y333": ["mRNA decay by 5' to 3' exoribonuclease", "mRNA decay by 5' to 3' exoribonuclease", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "Q9Y336": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation"], "Q9Y337": ["Formation of the cornified envelope", "Formation of the cornified envelope"], "Q9Y345": ["Na+/Cl- dependent neurotransmitter transporters", "Defective SLC6A5 causes hyperekplexia 3 (HKPX3)"], "Q9Y365": ["Synthesis of PC"], "Q9Y366": ["Hedgehog 'off' state", "Intraflagellar transport", "Intraflagellar transport"], "Q9Y375": ["Complex I biogenesis"], "Q9Y376": ["Energy dependent regulation of mTOR by LKB1-AMPK", "Neutrophil degranulation"], "Q9Y385": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q9Y399": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q9Y3A2": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "Q9Y3A4": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "Q9Y3A6": ["WNT ligand biogenesis and trafficking"], "Q9Y3B2": ["ATF4 activates genes", "mRNA decay by 3' to 5' exoribonuclease", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "KSRP (KHSRP) binds and destabilizes mRNA", "Major pathway of rRNA processing in the nucleolus and cytosol"], "Q9Y3B3": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "Q9Y3B4": ["mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "Q9Y3B7": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q9Y3C4": ["tRNA modification in the nucleus and cytosol"], "Q9Y3C6": ["mRNA Splicing - Major Pathway"], "Q9Y3C7": ["PPARA activates gene expression", "Generic Transcription Pathway", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation"], "Q9Y3D0": ["Cytosolic iron-sulfur cluster assembly"], "Q9Y3D2": ["Protein repair"], "Q9Y3D3": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q9Y3D5": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q9Y3D7": ["Mitochondrial protein import"], "Q9Y3D8": ["Interconversion of nucleotide di- and triphosphates"], "Q9Y3D9": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q9Y3E5": ["Ub-specific processing proteases"], "Q9Y3E7": ["Budding and maturation of HIV virion", "Macroautophagy", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "Q9Y3F4": ["Downregulation of TGF-beta receptor signaling", "Downregulation of TGF-beta receptor signaling"], "Q9Y3I0": ["tRNA processing in the nucleus"], "Q9Y3I1": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q9Y3L5": ["Neutrophil degranulation"], "Q9Y3M2": ["Deactivation of the beta-catenin transactivating complex"], "Q9Y3M8": ["Rho GTPase cycle"], "Q9Y3M9": ["Generic Transcription Pathway"], "Q9Y3N9": ["Olfactory Signaling Pathway"], "Q9Y3P9": ["TBC/RABGAPs"], "Q9Y3Q0": ["Amino acid synthesis and interconversion (transamination)"], "Q9Y3Q3": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "Q9Y3Q4": ["HCN channels"], "Q9Y3R0": ["Trafficking of GluR2-containing AMPA receptors"], "Q9Y3R4": ["Glycosphingolipid metabolism", "Sialic acid metabolism"], "Q9Y3S1": ["Stimuli-sensing channels"], "Q9Y3T9": ["Regulation of TP53 Activity through Phosphorylation"], "Q9Y3U8": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Peptide chain elongation", "SRP-dependent cotranslational protein targeting to membrane", "SRP-dependent cotranslational protein targeting to membrane", "Viral mRNA Translation", "Selenocysteine synthesis", "Major pathway of rRNA processing in the nucleolus and cytosol", "Formation of a pool of free 40S subunits", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Eukaryotic Translation Termination", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "Q9Y3V2": ["SUMO is transferred from E1 to E2 (UBE2I, UBC9)"], "Q9Y3Y2": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA 3'-end processing"], "Q9Y3Y4": ["Formation of the beta-catenin:TCF transactivating complex", "Deactivation of the beta-catenin transactivating complex"], "Q9Y3Z3": ["Nucleobase catabolism", "Interferon alpha/beta signaling"], "Q9Y446": ["Keratinization", "Formation of the cornified envelope"], "Q9Y450": ["mRNA decay by 3' to 5' exoribonuclease"], "Q9Y462": ["Generic Transcription Pathway"], "Q9Y466": ["Nuclear Receptor transcription pathway", "Regulation of PTEN gene transcription"], "Q9Y468": ["Regulation of TP53 Activity through Methylation"], "Q9Y473": ["Generic Transcription Pathway"], "Q9Y478": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Macroautophagy", "Activation of PPARGC1A (PGC-1alpha) by phosphorylation", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Regulation of TP53 Activity through Phosphorylation", "Activation of AMPK downstream of NMDARs"], "Q9Y483": ["PRC2 methylates histones and DNA"], "Q9Y484": ["Macroautophagy"], "Q9Y487": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "Q9Y490": ["Platelet degranulation ", "Integrin alphaIIb beta3 signaling", "GRB2:SOS provides linkage to MAPK signaling for Integrins ", "p130Cas linkage to MAPK signaling for integrins", "XBP1(S) activates chaperone genes", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "Smooth Muscle Contraction", "MAP2K and MAPK activation", "Signaling by moderate kinase activity BRAF mutants", "Signaling by high-kinase activity BRAF mutants", "Signaling by RAS mutants", "Signaling by BRAF and RAF fusions", "Paradoxical activation of RAF signaling by kinase inactive BRAF"], "Q9Y496": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "MHC class II antigen presentation", "Hedgehog 'off' state", "Intraflagellar transport", "Activation of SMO", "Activation of SMO", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins", "Kinesins"], "Q9Y4A5": ["Formation of the beta-catenin:TCF transactivating complex", "Formation of the beta-catenin:TCF transactivating complex", "HATs acetylate histones", "Ub-specific processing proteases"], "Q9Y4A9": ["Olfactory Signaling Pathway"], "Q9Y4B6": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q9Y4C0": ["Neurexins and neuroligins", "Neurexins and neuroligins"], "Q9Y4C1": ["HDMs demethylate histones"], "Q9Y4C5": ["Keratan sulfate biosynthesis"], "Q9Y4D1": ["PCP/CE pathway", "RHO GTPases Activate Formins"], "Q9Y4D2": ["Arachidonate production from DAG"], "Q9Y4D7": ["Other semaphorin interactions", "NOTCH3 Intracellular Domain Regulates Transcription"], "Q9Y4E8": ["Downregulation of TGF-beta receptor signaling", "UCH proteinases", "Ub-specific processing proteases"], "Q9Y4G8": ["RAF/MAP kinase cascade"], "Q9Y4H2": ["PI3K Cascade", "IRS-mediated signalling", "SOS-mediated signalling", "SOS-mediated signalling", "PIP3 activates AKT signaling", "Interleukin-7 signaling", "PI3K/AKT activation", "PI3K/AKT activation", "Constitutive Signaling by Aberrant PI3K in Cancer", "IRS-related events triggered by IGF1R", "Signaling by Leptin", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "IRS activation", "Signal attenuation", "RET signaling", "Signaling by Erythropoietin", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "Erythropoietin activates Phospholipase C gamma (PLCG)", "Erythropoietin activates STAT5", "Erythropoietin activates RAS", "Erythropoietin activates RAS", "Growth hormone receptor signaling"], "Q9Y4H4": ["G alpha (i) signalling events"], "Q9Y4I1": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Regulation of actin dynamics for phagocytic cup formation", "Insulin processing"], "Q9Y4K0": ["Elastic fibre formation", "Crosslinking of collagen fibrils"], "Q9Y4K3": ["PIP3 activates AKT signaling", "MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "NOD1/2 Signaling Pathway", "TICAM1, RIP1-mediated IKK complex recruitment ", "Regulated proteolysis of p75NTR", "Downstream TCR signaling", "NRIF signals cell death from the nucleus", "NRIF signals cell death from the nucleus", "p75NTR recruits signalling complexes", "NF-kB is activated and signals survival", "FCERI mediated NF-kB activation", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "activated TAK1 mediates p38 MAPK activation", "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "CLEC7A (Dectin-1) signaling", "Ub-specific processing proteases", "Ovarian tumor domain proteases", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "TICAM1,TRAF6-dependent induction of TAK1 complex", "Interleukin-1 signaling", "TRAF6 mediated IRF7 activation", "TRAF6 mediated NF-kB activation", "TRAF6 mediated NF-kB activation", "IRAK1 recruits IKK complex", "IKK complex recruitment mediated by RIP1", "IRAK2 mediated activation of TAK1 complex", "TRAF6-mediated induction of TAK1 complex within TLR4 complex", "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "MyD88 dependent cascade initiated on endosome", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "MyD88 cascade initiated on plasma membrane"], "Q9Y4L1": ["Scavenging by Class F Receptors", "Scavenging by Class F Receptors", "XBP1(S) activates chaperone genes"], "Q9Y4L5": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q9Y4P1": ["Macroautophagy"], "Q9Y4P8": ["Macroautophagy"], "Q9Y4R7": ["Carboxyterminal post-translational modifications of tubulin"], "Q9Y4U1": ["Cobalamin (Cbl, vitamin B12) transport and metabolism", "Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD", "Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC"], "Q9Y4W2": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "Q9Y4W6": ["Processing of SMDT1"], "Q9Y4X1": ["Glucuronidation"], "Q9Y4X3": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "Q9Y4X5": ["ISG15 antiviral mechanism"], "Q9Y4Y9": ["mRNA decay by 5' to 3' exoribonuclease", "mRNA decay by 5' to 3' exoribonuclease", "mRNA Splicing - Major Pathway"], "Q9Y4Z0": ["mRNA decay by 5' to 3' exoribonuclease", "mRNA decay by 5' to 3' exoribonuclease", "mRNA Splicing - Major Pathway"], "Q9Y4Z2": ["Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells", "Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells"], "Q9Y508": ["Antigen processing: Ubiquitination & Proteasome degradation"], "Q9Y512": ["Mitochondrial protein import", "Cristae formation"], "Q9Y535": ["Cytosolic sensors of pathogen-associated DNA ", "RNA Polymerase III Chain Elongation", "RNA Polymerase III Transcription Termination", "RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "Q9Y547": ["Intraflagellar transport", "Intraflagellar transport"], "Q9Y561": ["Retinoid metabolism and transport"], "Q9Y566": ["Neurexins and neuroligins", "Neurexins and neuroligins"], "Q9Y570": ["Cyclin A/B1/B2 associated events during G2/M transition"], "Q9Y572": ["TICAM1, RIP1-mediated IKK complex recruitment ", "RIP-mediated NFkB activation via ZBP1", "TRIF-mediated programmed cell death", "TRP channels", "RIPK1-mediated regulated necrosis", "TLR3-mediated TICAM1-dependent programmed cell death", "IKK complex recruitment mediated by RIP1"], "Q9Y574": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q9Y575": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q9Y576": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q9Y577": ["Interferon gamma signaling"], "Q9Y584": ["Mitochondrial protein import", "Mitochondrial protein import"], "Q9Y585": ["Olfactory Signaling Pathway"], "Q9Y587": ["Lysosome Vesicle Biogenesis"], "Q9Y592": ["Anchoring of the basal body to the plasma membrane"], "Q9Y5A7-1": ["Neddylation"], "Q9Y5A7-2": ["Neddylation"], "Q9Y5B0": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of the HIV-1 Early Elongation Complex", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Abortive elongation of HIV-1 transcript in the absence of Tat", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "RNA Polymerase II Transcription Elongation"], "Q9Y5B8": ["Recruitment of mitotic centrosome proteins and complexes", "Recruitment of NuMA to mitotic centrosomes"], "Q9Y5B9": ["Formation of RNA Pol II elongation complex ", "Formation of HIV elongation complex in the absence of HIV Tat", "Formation of HIV-1 elongation complex containing HIV-1 Tat", "Pausing and recovery of Tat-mediated HIV elongation", "Tat-mediated HIV elongation arrest and recovery", "Tat-mediated elongation of the HIV-1 transcript", "HIV elongation arrest and recovery", "Pausing and recovery of HIV elongation", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "Regulation of TP53 Activity through Phosphorylation", "RNA Polymerase II Transcription Elongation"], "Q9Y5C1": ["Assembly of active LPL and LIPC lipase complexes"], "Q9Y5I7": ["Tight junction interactions"], "Q9Y5J1": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "Q9Y5J3": ["NOTCH1 Intracellular Domain Regulates Transcription", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "RUNX2 regulates osteoblast differentiation", "NOTCH3 Intracellular Domain Regulates Transcription", "NOTCH4 Intracellular Domain Regulates Transcription"], "Q9Y5J6": ["Mitochondrial protein import"], "Q9Y5J7": ["Mitochondrial protein import", "Mitochondrial protein import"], "Q9Y5J9": ["Mitochondrial protein import"], "Q9Y5K1": ["Meiotic recombination"], "Q9Y5K3": ["Synthesis of PC"], "Q9Y5K5": ["Downregulation of TGF-beta receptor signaling", "UCH proteinases", "UCH proteinases"], "Q9Y5K6": ["Nephrin family interactions"], "Q9Y5K8": ["ROS, RNS production in phagocytes", "Neutrophil degranulation", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "Q9Y5L2": ["Lipid particle organization"], "Q9Y5L3": ["Phosphate bond hydrolysis by NTPDase proteins"], "Q9Y5L4": ["Mitochondrial protein import"], "Q9Y5M8": ["SRP-dependent cotranslational protein targeting to membrane", "XBP1(S) activates chaperone genes"], "Q9Y5N1": ["Histamine receptors", "G alpha (i) signalling events"], "Q9Y5N5": ["Methylation", "Eukaryotic Translation Termination"], "Q9Y5N6": ["E2F-enabled inhibition of pre-replication complex formation", "Activation of ATR in response to replication stress", "Assembly of the ORC complex at the origin of replication", "CDC6 association with the ORC:origin complex", "CDT1 association with the CDC6:ORC:origin complex", "Assembly of the pre-replicative complex", "Orc1 removal from chromatin", "Activation of the pre-replicative complex"], "Q9Y5P0": ["Olfactory Signaling Pathway"], "Q9Y5P1": ["Olfactory Signaling Pathway"], "Q9Y5P4-2": ["Sphingolipid de novo biosynthesis"], "Q9Y5P6": ["Synthesis of GDP-mannose"], "Q9Y5P8": ["Inhibition of replication initiation of damaged DNA by RB1/E2F1", "Cyclin D associated events in G1", "Cyclin A/B1/B2 associated events during G2/M transition"], "Q9Y5Q3": ["Activation of anterior HOX genes in hindbrain development during early embryogenesis"], "Q9Y5Q5": ["Physiological factors"], "Q9Y5Q6": ["G alpha (i) signalling events", "Relaxin receptors"], "Q9Y5Q8": ["RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter"], "Q9Y5Q9": ["RNA Polymerase III Abortive And Retractive Initiation", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter"], "Q9Y5R2": ["Activation of Matrix Metalloproteinases"], "Q9Y5R8": ["COPII-mediated vesicle transport", "Neutrophil degranulation", "RAB GEFs exchange GTP for GDP on RABs"], "Q9Y5S1": ["TRP channels"], "Q9Y5S8": ["RHO GTPases Activate NADPH Oxidases"], "Q9Y5S9": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Regulation of expression of SLITs and ROBOs", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "Q9Y5T5": ["Ub-specific processing proteases"], "Q9Y5U4": ["Regulation of cholesterol biosynthesis by SREBP (SREBF)"], "Q9Y5U5": ["TNFs bind their physiological receptors", "RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)"], "Q9Y5U8": ["Pyruvate metabolism"], "Q9Y5V0": ["Generic Transcription Pathway"], "Q9Y5V3": ["NRAGE signals death through JNK", "Caspase activation via Dependence Receptors in the absence of ligand"], "Q9Y5W5": ["TCF dependent signaling in response to WNT", "Negative regulation of TCF-dependent signaling by WNT ligand antagonists"], "Q9Y5X1": ["Golgi Associated Vesicle Biogenesis", "Clathrin-mediated endocytosis"], "Q9Y5X3": ["Golgi Associated Vesicle Biogenesis"], "Q9Y5X4-1": ["Nuclear Receptor transcription pathway"], "Q9Y5X4-2": ["Nuclear Receptor transcription pathway"], "Q9Y5X5": ["Orexin and neuropeptides FF and QRFP bind to their respective receptors", "G alpha (q) signalling events"], "Q9Y5X9": ["HDL remodeling"], "Q9Y5Y0": ["Iron uptake and transport"], "Q9Y5Y2": ["Cytosolic iron-sulfur cluster assembly"], "Q9Y5Y3": ["G alpha (s) signalling events"], "Q9Y5Y4": ["Prostanoid ligand receptors", "G alpha (i) signalling events"], "Q9Y5Y6": ["Formation of the cornified envelope", "Formation of the cornified envelope"], "Q9Y5Y7": ["Hyaluronan uptake and degradation"], "Q9Y5Y9": ["Interaction between L1 and Ankyrins", "Phase 0 - rapid depolarisation"], "Q9Y5Z4": ["Neutrophil degranulation"], "Q9Y5Z9": ["Metabolism of vitamin K"], "Q9Y600": ["Degradation of cysteine and homocysteine"], "Q9Y606-1": ["tRNA modification in the mitochondrion"], "Q9Y606-2": ["tRNA modification in the nucleus and cytosol"], "Q9Y616": ["MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "Interleukin-1 signaling"], "Q9Y617": ["Serine biosynthesis"], "Q9Y618": ["PPARA activates gene expression", "NOTCH1 Intracellular Domain Regulates Transcription", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "HDACs deacetylate histones", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation", "SUMOylation of transcription cofactors", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)", "Loss of MECP2 binding ability to the NCoR/SMRT complex", "Regulation of MECP2 expression and activity"], "Q9Y619": ["Urea cycle"], "Q9Y624": ["Cell surface interactions at the vascular wall", "Integrin cell surface interactions", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "Tight junction interactions"], "Q9Y625": ["A tetrasaccharide linker sequence is required for GAG synthesis", "HS-GAG biosynthesis", "HS-GAG biosynthesis", "HS-GAG degradation", "Defective B4GALT7 causes EDS, progeroid type", "Defective B3GAT3 causes JDSSDHD", "Defective EXT2 causes exostoses 2", "Defective EXT1 causes exostoses 1, TRPS2 and CHDS", "Defective B3GALT6 causes EDSP2 and SEMDJL1", "Retinoid metabolism and transport"], "Q9Y639": ["GABA receptor activation"], "Q9Y644": ["Pre-NOTCH Processing in Golgi"], "Q9Y661": ["HS-GAG biosynthesis"], "Q9Y662": ["HS-GAG biosynthesis"], "Q9Y663": ["HS-GAG biosynthesis"], "Q9Y666": ["Cation-coupled Chloride cotransporters"], "Q9Y672": ["Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "Defective ALG6 causes ALG6-CDG (CDG-1c)"], "Q9Y673": ["Synthesis of dolichyl-phosphate-glucose"], "Q9Y676": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q9Y678": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "Q9Y691": ["Ca2+ activated K+ channels", "cGMP effects"], "Q9Y694": ["Organic anion transport"], "Q9Y697-1": ["Mitochondrial iron-sulfur cluster biogenesis"], "Q9Y697-2": ["Molybdenum cofactor biosynthesis"], "Q9Y698": ["Presynaptic depolarization and calcium channel opening", "Trafficking of AMPA receptors", "Phase 0 - rapid depolarisation", "Phase 2 - plateau phase", "LGI-ADAM interactions"], "Q9Y6A1": ["Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1", "O-linked glycosylation"], "Q9Y6A2": ["Synthesis of bile acids and bile salts via 24-hydroxycholesterol", "Endogenous sterols"], "Q9Y6A5": ["NOTCH3 Activation and Transmission of Signal to the Nucleus", "Negative regulation of NOTCH4 signaling"], "Q9Y6A9": ["SRP-dependent cotranslational protein targeting to membrane", "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)", "Synthesis, secretion, and deacylation of Ghrelin"], "Q9Y6B6": ["Regulation of cholesterol biosynthesis by SREBP (SREBF)", "COPII-mediated vesicle transport", "MHC class II antigen presentation", "Cargo concentration in the ER", "Chylomicron assembly", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "Q9Y6B7": ["Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis"], "Q9Y6C2": ["Molecules associated with elastic fibres", "Molecules associated with elastic fibres"], "Q9Y6C5": ["Class B/2 (Secretin family receptors)"], "Q9Y6D5": ["Association of TriC/CCT with target proteins during biosynthesis"], "Q9Y6D9": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "Q9Y6E0": ["Apoptotic cleavage of cellular proteins", "Apoptotic execution phase"], "Q9Y6E7": ["Transcriptional activation of mitochondrial biogenesis"], "Q9Y6F6": ["cGMP effects"], "Q9Y6F9": ["WNT ligand biogenesis and trafficking", "WNT ligand biogenesis and trafficking", "Class B/2 (Secretin family receptors)"], "Q9Y6G3": ["Mitochondrial translation initiation", "Mitochondrial translation elongation", "Mitochondrial translation elongation", "Mitochondrial translation termination"], "Q9Y6G5": ["Neddylation"], "Q9Y6G9": ["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "RHO GTPases Activate Formins", "Neutrophil degranulation", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase"], "Q9Y6H1": ["Mitochondrial protein import"], "Q9Y6H5": ["Amyloid fiber formation"], "Q9Y6H5-2": ["Amyloid fiber formation"], "Q9Y6H6": ["Phase 3 - rapid repolarisation", "Phase 2 - plateau phase"], "Q9Y6H8": ["Gap junction assembly"], "Q9Y6I3": ["EGFR downregulation", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "Q9Y6I4": ["Ub-specific processing proteases"], "Q9Y6I7": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "Q9Y6I9": ["Platelet degranulation "], "Q9Y6J0": ["Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "Q9Y6J6": ["Phase 3 - rapid repolarisation", "Phase 2 - plateau phase"], "Q9Y6J9": ["HATs acetylate histones"], "Q9Y6K0": ["Synthesis of PC", "Synthesis of PE"], "Q9Y6K1": ["PRC2 methylates histones and DNA", "RMTs methylate histone arginines", "SUMOylation of DNA methylation proteins", "DNA methylation"], "Q9Y6K5": ["Interferon gamma signaling", "OAS antiviral response", "Interferon alpha/beta signaling"], "Q9Y6K8": ["Interconversion of nucleotide di- and triphosphates"], "Q9Y6K9": ["Activation of NF-kappaB in B cells", "Activation of NF-kappaB in B cells", "ER-Phagosome pathway", "NOD1/2 Signaling Pathway", "TICAM1, RIP1-mediated IKK complex recruitment ", "RIP-mediated NFkB activation via ZBP1", "Downstream TCR signaling", "FCERI mediated NF-kB activation", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "activated TAK1 mediates p38 MAPK activation", "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1", "SUMOylation of immune response proteins", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "IKBKB deficiency causes SCID", "IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)", "IkBA variant leads to EDA-ID", "CLEC7A (Dectin-1) signaling", "MAP3K8 (TPL2)-dependent MAPK1/3 activation", "Ub-specific processing proteases", "Ovarian tumor domain proteases", "Interleukin-1 signaling", "TRAF6 mediated NF-kB activation", "NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10", "IRAK1 recruits IKK complex", "IKK complex recruitment mediated by RIP1", "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation"], "Q9Y6L6": ["Recycling of bile acids and salts", "Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)", "Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)", "Transport of organic anions"], "Q9Y6L7": ["Degradation of the extracellular matrix", "Collagen biosynthesis and modifying enzymes", "Anchoring fibril formation", "Crosslinking of collagen fibrils"], "Q9Y6M0": ["Post-translational modification: synthesis of GPI-anchored proteins"], "Q9Y6M1": ["Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA"], "Q9Y6M5": ["Zinc efflux and compartmentalization by the SLC30 family"], "Q9Y6M7": ["Bicarbonate transporters"], "Q9Y6M9": ["Respiratory electron transport", "Complex I biogenesis"], "Q9Y6N1": ["TP53 Regulates Metabolic Genes", "Respiratory electron transport"], "Q9Y6N3": ["Stimuli-sensing channels"], "Q9Y6N5": ["Sulfide oxidation to sulfate", "Sulfide oxidation to sulfate"], "Q9Y6N6": ["Laminin interactions", "Laminin interactions", "Non-integrin membrane-ECM interactions", "MET activates PTK2 signaling"], "Q9Y6N7": ["Netrin-1 signaling", "Signaling by ROBO receptors", "Signaling by ROBO receptors", "Activation of RAC1", "Regulation of commissural axon pathfinding by SLIT and ROBO", "Regulation of commissural axon pathfinding by SLIT and ROBO", "Inactivation of CDC42 and RAC1", "Role of ABL in ROBO-SLIT signaling", "Role of ABL in ROBO-SLIT signaling", "SLIT2:ROBO1 increases RHOA activity", "Regulation of cortical dendrite branching", "Regulation of expression of SLITs and ROBOs", "Regulation of expression of SLITs and ROBOs"], "Q9Y6N8": ["Adherens junctions interactions"], "Q9Y6P5-1": ["TP53 Regulates Metabolic Genes"], "Q9Y6P5-3": ["TP53 Regulates Metabolic Genes"], "Q9Y6Q1": ["Degradation of the extracellular matrix"], "Q9Y6Q2": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "Q9Y6Q3": ["Generic Transcription Pathway"], "Q9Y6Q5": ["Nef mediated downregulation of MHC class I complex cell surface expression", "MHC class II antigen presentation", "Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis"], "Q9Y6Q6": ["TNFR2 non-canonical NF-kB pathway", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "Q9Y6Q9": ["PPARA activates gene expression", "Transcriptional regulation of white adipocyte differentiation", "Transcriptional regulation of white adipocyte differentiation", "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "MAPK6/MAPK4 signaling", "Estrogen-dependent gene expression"], "Q9Y6R1": ["Bicarbonate transporters", "Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)"], "Q9Y6T7": ["Effects of PIP2 hydrolysis"], "Q9Y6V7": ["rRNA modification in the nucleus and cytosol", "Major pathway of rRNA processing in the nucleolus and cytosol"], "Q9Y6W3": ["Degradation of the extracellular matrix"], "Q9Y6W5": ["Regulation of actin dynamics for phagocytic cup formation", "Regulation of actin dynamics for phagocytic cup formation", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate WASPs and WAVEs"], "Q9Y6W6": ["RAF-independent MAPK1/3 activation", "Negative regulation of MAPK pathway"], "Q9Y6W8-1": ["PIP3 activates AKT signaling", "Constitutive Signaling by Aberrant PI3K in Cancer", "Costimulation by the CD28 family", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "Q9Y6X1": ["XBP1(S) activates chaperone genes"], "Q9Y6X2": ["SUMOylation of transcription factors", "SUMOylation of transcription cofactors", "SUMOylation of intracellular receptors", "SUMOylation of DNA replication proteins", "SUMOylation of immune response proteins", "Formation of Incision Complex in GG-NER"], "Q9Y6X3": ["Cohesin Loading onto Chromatin"], "Q9Y6X5": ["Neutrophil degranulation"], "Q9Y6X9": ["Fatty acyl-CoA biosynthesis"], "Q9Y6Y8": ["COPII-mediated vesicle transport"], "Q9Y6Y9": ["ER-Phagosome pathway", "Caspase activation via Death Receptors in the presence of ligand", "Toll Like Receptor 4 (TLR4) Cascade", "MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "MyD88-independent TLR4 cascade ", "TRIF-mediated programmed cell death", "MyD88 deficiency (TLR2/4)", "IRAK4 deficiency (TLR2/4)", "Regulation of TLR by endogenous ligand", "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon", "IKK complex recruitment mediated by RIP1", "TRAF6-mediated induction of TAK1 complex within TLR4 complex", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"], "Q9Y6Z7": ["Lectin pathway of complement activation", "Initial triggering of complement"]}}}