view tool-data/Rat_biogrid_2019-03-01 @ 5:ba96ca3496a2 draft default tip

"planemo upload commit c9a32e920aae2bc186183611bc0abb2040e106f3"

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"27139", "STXBP5L", "Rps26", "Affinity Capture-MS", "physical", "25002582", "-", "-"], ["9515", "100365943", "STXBP5L", "LOC100365943", "Affinity Capture-MS", "physical", "25002582", "-", "-"], ["9515", "100359583", "STXBP5L", "LOC100359583", "Affinity Capture-MS", "physical", "25002582", "-", "-"], ["9515", "100360508", "STXBP5L", "LOC100360508", "Affinity Capture-MS", "physical", "25002582", "-", "-"], ["9515", "408248", "STXBP5L", "Psma3l", "Affinity Capture-MS", "physical", "25002582", "-", "-"], ["9515", "100361008", "STXBP5L", "LOC100361008", "Affinity Capture-MS", "physical", "25002582", "-", "-"]], "9531": [["9531", "25420", "BAG3", "Cryab", "Affinity Capture-Western", "physical", "21423662", "-", "-"], ["9531", "24468", "BAG3", "Hspa8", "Affinity Capture-Western", "physical", "21423662", "-", "-"]], "9611": [["9611", "24413", "NCOR1", "Nr3c1", "Two-hybrid", "physical", "15016838", "-", "-"]], "9612": [["9612", "24413", "NCOR2", "Nr3c1", "Two-hybrid", "physical", "15016838", 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"29619", "HDAC4", "Btg2", "Affinity Capture-Western", "physical", "27333946", "-", "-"], ["9759", "29619", "HDAC4", "Btg2", "Reconstituted Complex", "physical", "17371797", "-", "-"]], "983": [["983", "116685", "CDK1", "Lmnb1", "Biochemical Activity", "physical", "9053846", "-", "-"]], "9833": [["9833", "60581", "MELK", "Acaca", "Biochemical Activity", "physical", "16216881", "-", "-"]], "99375": [["99375", "81807", "Cul4a", "Tceb2", "Affinity Capture-Western", "physical", "19037258", "-", "-"], ["99375", "25562", "Cul4a", "Tceb3", "Affinity Capture-Western", "physical", "19037258", "-", "-"], ["99375", "64525", "Cul4a", "Tceb1", "Affinity Capture-Western", "physical", "19037258", "-", "-"]], "Entrez Gene Interactor A": [["Entrez Gene Interactor A", "Entrez Gene Interactor B", "Official Symbol Interactor A", "Official Symbol Interactor B", "Experimental System", "Experimental System Type", "Pubmed ID", "Score", "Phenotypes"]]}, "nodes": {"100124593": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "100125364": ["Neutrophil degranulation"], "100125370": ["Nicotinate metabolism"], "100125373": ["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "100126191": ["Golgi Cisternae Pericentriolar Stack Reorganization", "COPII-mediated vesicle transport", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "100134871": ["Erythrocytes take up carbon dioxide and release oxygen", "Erythrocytes take up oxygen and release carbon dioxide", "Scavenging of heme from plasma", "Neutrophil degranulation"], "100145871": ["Ethanol oxidation"], "100147704": ["Termination of translesion DNA synthesis"], "100158223": ["Generic Transcription Pathway"], "100158232": ["Generic Transcription Pathway"], "100158233": ["Transport of nucleotide sugars"], "100169747": ["Collagen degradation", "Lysine catabolism"], "100188936": ["Sphingolipid de novo biosynthesis"], "100270683": ["Proline catabolism"], "100310876": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "100310877": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "100310878": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "100310879": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "100310880": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "100310881": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "100310885": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "100310886": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "100312983": ["HDMs demethylate histones"], "100359464": ["Generic Transcription Pathway", "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release"], "100359478": ["Sulfide oxidation to sulfate"], "100359503": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "100359574": ["Major pathway of rRNA processing in the nucleolus and cytosol", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "100359680": ["Acyl chain remodelling of PC"], "100359687": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "100359821": ["Generic Transcription Pathway"], "100359826": ["Keratinization"], "100359836": ["Nephrin family interactions"], "100359886": ["Keratinization"], "100359937": ["Macroautophagy", "TBC/RABGAPs"], "100359951": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "100360057": ["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "100360071": ["Peptide ligand-binding receptors", "G alpha (q) signalling events", "G alpha (s) signalling events"], "100360087": ["Golgi Associated Vesicle Biogenesis", "Neutrophil degranulation", "Iron uptake and transport"], "100360100": ["RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "100360218": ["Interleukin-4 and Interleukin-13 signaling"], "100360302": ["COPII-mediated vesicle transport"], "100360342": ["Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)"], "100360406": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "100360427": ["G0 and Early G1", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Cyclin D associated events in G1"], "100360464": ["Synthesis, secretion, and deacylation of Ghrelin"], "100360522": ["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "100360552": ["PCP/CE pathway", "Asymmetric localization of PCP proteins"], "100360606": ["Ovarian tumor domain proteases"], "100360621": ["Phenylalanine and tyrosine catabolism"], "100360679": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "100360750": ["mRNA decay by 5' to 3' exoribonuclease", "mRNA Splicing - Major Pathway"], "100360754": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Metalloprotease DUBs", "Deposition of new CENPA-containing nucleosomes at the centromere", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "100360828": ["MASTL Facilitates Mitotic Progression"], "100360846": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "100360919": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Scavenging of heme from plasma", "Fc epsilon receptor (FCERI) signaling", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD22 mediated BCR regulation", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "100360936": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6"], "100360940": ["Release of apoptotic factors from the mitochondria", "SMAC (DIABLO) binds to IAPs ", "SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ", "SMAC, XIAP-regulated apoptotic response"], "100361138": ["Effects of PIP2 hydrolysis"], "100361269": ["mRNA Splicing - Major Pathway"], "100361294": ["Interleukin-6 signaling", "MAPK3 (ERK1) activation", "MAPK1 (ERK2) activation", "Interleukin-10 signaling", "Interleukin-4 and Interleukin-13 signaling", "IL-6-type cytokine receptor ligand interactions", "Interleukin-20 family signaling", "Interleukin-35 Signalling", "Interleukin-12 signaling", "Interleukin-23 signaling", "Interleukin-27 signaling", "Interferon alpha/beta signaling", "Regulation of IFNA signaling"], "100361444": ["Assembly of active LPL and LIPC lipase complexes"], "100361457": ["Gap junction degradation", "Formation of annular gap junctions", "Regulation of actin dynamics for phagocytic cup formation", "EPHB-mediated forward signaling", "Adherens junctions interactions", "Recycling pathway of L1", "VEGFA-VEGFR2 Pathway", "Interaction between L1 and Ankyrins", "Cell-extracellular matrix interactions", "RHO GTPases activate IQGAPs", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate Formins", "MAP2K and MAPK activation", "Clathrin-mediated endocytosis"], "100361468": ["Activation, myristolyation of BID and translocation to mitochondria"], "100361492": ["Xenobiotics"], "100361513": ["Retrograde transport at the Trans-Golgi-Network"], "100361529": ["Activation of ATR in response to replication stress", "HDR through Single Strand Annealing (SSA)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange"], "100361543": ["Macroautophagy", "mTOR signalling", "mTORC1-mediated signalling", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Neutrophil degranulation", "Regulation of PTEN gene transcription"], "100361558": ["PRC2 methylates histones and DNA", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression", "Factors involved in megakaryocyte development and platelet production"], "100361571": ["Keratinization"], "100361574": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase I Transcription Termination", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Pol II CTD phosphorylation and interaction with CE", "Estrogen-dependent gene expression"], "100361584": ["Stimuli-sensing channels"], "100361626": ["Keratinization"], "100361647": ["O-linked glycosylation of mucins"], "100361652": ["Formation of the cornified envelope"], "100361658": ["Ub-specific processing proteases"], "100361664": ["Keratinization"], "100361710": ["PKMTs methylate histone lysines"], "100361739": ["Keratinization"], "100361793": ["Keratinization"], "100361854": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "100361866": ["Neutrophil degranulation", "Antimicrobial peptides"], "100361909": ["Neutrophil degranulation", "Antimicrobial peptides"], "100361951": ["Formation of the cornified envelope"], "100362027": ["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "100362121": ["Ub-specific processing proteases", "DNA Damage Recognition in GG-NER", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "Neddylation"], "100362124": ["Hedgehog 'off' state", "Intraflagellar transport"], "100362149": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "100362207": ["Keratinization"], "100362350": ["The canonical retinoid cycle in rods (twilight vision)"], "100362547": ["Lysosome Vesicle Biogenesis"], "100362554": ["Regulation of TNFR1 signaling", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes"], "100362555": ["Sphingolipid de novo biosynthesis"], "100362588": ["Sperm:Oocyte Membrane Binding"], "100362640": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "100362678": ["Transcriptional Regulation by E2F6"], "100362684": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "100362710": ["NRAGE signals death through JNK", "Rho GTPase cycle"], "100362805": ["Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis", "Neutrophil degranulation"], "100362830": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "100362978": ["Formation of the cornified envelope"], "100363074": ["Mitochondrial Fatty Acid Beta-Oxidation"], "100363136": ["Keratinization"], "100363184": ["Keratinization"], "100363253": ["Abacavir metabolism", "Purine catabolism"], "100363268": ["Respiratory electron transport", "Complex I biogenesis"], "100363287": ["Keratinization"], "100363439": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "100363492": ["Post-translational modification: synthesis of GPI-anchored proteins"], "100363539": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "100363782": ["Golgi Cisternae Pericentriolar Stack Reorganization", "COPII-mediated vesicle transport", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "100364500": ["ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "100364523": ["Collagen degradation", "Degradation of the extracellular matrix", "Trafficking and processing of endosomal TLR", "Assembly of collagen fibrils and other multimeric structures", "MHC class II antigen presentation", "RUNX1 regulates transcription of genes involved in differentiation of keratinocytes"], "100364550": ["Keratinization"], "100364568": ["RNA polymerase II transcribes snRNA genes"], "100364613": ["Keratinization"], "100364835": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HATs acetylate histones", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "E3 ubiquitin ligases ubiquitinate target proteins", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "100364984": ["Neutrophil degranulation", "RAB geranylgeranylation"], "100365043": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HATs acetylate histones", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "E3 ubiquitin ligases ubiquitinate target proteins", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "100365112": ["Phase I - Functionalization of compounds"], "100365588": ["Keratinization"], "100365773": ["Melanin biosynthesis"], "100365779": ["Generic Transcription Pathway"], "100365921": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "100365958": ["The canonical retinoid cycle in rods (twilight vision)", "RA biosynthesis pathway"], "100366024": ["PKMTs methylate histone lysines"], "100909438": ["Olfactory Signaling Pathway"], "100909441": ["Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Recruitment of NuMA to mitotic centrosomes", "Recycling pathway of L1", "Hedgehog 'off' state", "Cilium Assembly", "Intraflagellar transport", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "Carboxyterminal post-translational modifications of tubulin", "Kinesins"], "100909505": ["Keratan sulfate degradation", "Lysosome Vesicle Biogenesis", "Neutrophil degranulation"], "100909524": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "100909534": ["Olfactory Signaling Pathway"], "100909548": ["Lysosome Vesicle Biogenesis", "Retrograde transport at the Trans-Golgi-Network", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "100909578": ["Olfactory Signaling Pathway"], "100909595": ["Cellular hexose transport", "Vitamin C (ascorbate) metabolism", "Neutrophil degranulation"], "100909605": ["Platelet degranulation ", "Neutrophil degranulation"], "100909648": ["Vasopressin-like receptors", "G alpha (q) signalling events"], "100909661": ["Keratinization"], "100909671": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation"], "100909725": ["Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)", "Phase 4 - resting membrane potential"], "100909750": ["Regulation of actin dynamics for phagocytic cup formation", "CDO in myogenesis", "Role of ABL in ROBO-SLIT signaling", "RHO GTPases Activate WASPs and WAVEs", "HDR through Single Strand Annealing (SSA)", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Cyclin D associated events in G1", "RUNX1 regulates transcription of genes involved in differentiation of HSCs"], "100909796": ["Olfactory Signaling Pathway"], "100909831": ["Olfactory Signaling Pathway"], "100909840": ["Signaling by ROBO receptors", "RHO GTPases Activate Formins"], "100909849": ["Asymmetric localization of PCP proteins", "Regulation of FZD by ubiquitination"], "100909857": ["Neutrophil degranulation", "Pyrimidine salvage"], "100909885": ["Olfactory Signaling Pathway"], "100909894": ["Olfactory Signaling Pathway"], "100909966": ["Olfactory Signaling Pathway"], "100909977": ["Cell surface interactions at the vascular wall", "Integrin cell surface interactions", "Signal regulatory protein family interactions", "Neutrophil degranulation"], "100909993": ["Olfactory Signaling Pathway"], "100910009": ["Olfactory Signaling Pathway"], "100910010": ["Olfactory Signaling Pathway"], "100910041": ["Olfactory Signaling Pathway"], "100910049": ["Olfactory Signaling Pathway"], "100910051": ["Olfactory Signaling Pathway"], "100910067": ["Detoxification of Reactive Oxygen Species"], "100910068": ["Post-translational modification: synthesis of GPI-anchored proteins"], "100910143": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "100910144": ["Phase I - Functionalization of compounds"], "100910162": ["Olfactory Signaling Pathway"], "100910181": ["VLDL assembly", "VLDL clearance"], "100910199": ["Olfactory Signaling Pathway"], "100910200": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HATs acetylate histones", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "E3 ubiquitin ligases ubiquitinate target proteins", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "100910202": ["mRNA Splicing - Major Pathway"], "100910224": ["Olfactory Signaling Pathway"], "100910231": ["Generic Transcription Pathway"], "100910245": ["5-Phosphoribose 1-diphosphate biosynthesis"], "100910256": ["Olfactory Signaling Pathway"], "100910270": ["Neutrophil degranulation"], "100910294": ["Olfactory Signaling Pathway"], "100910318": ["COPII-mediated vesicle transport", "RAB GEFs exchange GTP for GDP on RABs"], "100910335": ["Olfactory Signaling Pathway"], "100910402": ["Olfactory Signaling Pathway"], "100910409": ["Olfactory Signaling Pathway"], "100910410": ["Post-translational modification: synthesis of GPI-anchored proteins"], "100910439": ["Olfactory Signaling Pathway"], "100910445": ["Olfactory Signaling Pathway"], "100910481": ["Phase I - Functionalization of compounds"], "100910506": ["Dopamine Neurotransmitter Release Cycle", "Neurexins and neuroligins"], "100910526": ["Cytosolic sulfonation of small molecules"], "100910528": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "100910557": ["COPI-mediated anterograde transport"], "100910669": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "100910732": ["Generation of second messenger molecules", "FCERI mediated MAPK activation", "CD28 dependent Vav1 pathway", "Ephrin signaling", "Sema3A PAK dependent Axon repulsion", "VEGFA-VEGFR2 Pathway", "Smooth Muscle Contraction", "VEGFR2 mediated vascular permeability", "CD209 (DC-SIGN) signaling", "RHO GTPases activate PAKs", "MAPK6/MAPK4 signaling"], "100910771": ["NOD1/2 Signaling Pathway", "Downstream TCR signaling", "FCERI mediated NF-kB activation", "Ca2+ pathway", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "TNFR1-induced NFkappaB signaling pathway", "CLEC7A (Dectin-1) signaling", "Ub-specific processing proteases", "Interleukin-1 signaling", "IRAK2 mediated activation of TAK1 complex", "TRAF6-mediated induction of TAK1 complex within TLR4 complex", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"], "100910790": ["O-glycosylation of TSR domain-containing proteins"], "100910814": ["Keratinization"], "100910823": ["ABC-family proteins mediated transport", "Hedgehog ligand biogenesis", "ER Quality Control Compartment (ERQC)"], "100910837": ["Olfactory Signaling Pathway"], "100910851": ["Formation of the cornified envelope"], "100910876": ["Olfactory Signaling Pathway"], "100910877": ["Miscellaneous substrates", "Xenobiotics", "Aflatoxin activation and detoxification", "Biosynthesis of maresin-like SPMs"], "100910928": ["Olfactory Signaling Pathway"], "100910942": ["Formation of the cornified envelope"], "100910990": ["Glycerophospholipid biosynthesis", "Neutrophil degranulation"], "100910999": ["Olfactory Signaling Pathway"], "100911034": ["Mitochondrial iron-sulfur cluster biogenesis", "Molybdenum cofactor biosynthesis"], "100911043": ["Olfactory Signaling Pathway"], "100911186": ["Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA"], "100911204": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Deposition of new CENPA-containing nucleosomes at the centromere", "Mitotic Prometaphase"], "100911224": ["Generic Transcription Pathway"], "100911225": ["GDP-fucose biosynthesis"], "100911248": ["Frs2-mediated activation", "Downstream signal transduction", "MET activates RAP1 and RAC1", "MET receptor recycling", "Erythropoietin activates RAS", "Regulation of signaling by CBL"], "100911249": ["Interleukin-20 family signaling"], "100911295": ["Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER"], "100911348": ["Olfactory Signaling Pathway"], "100911356": ["ABC transporters in lipid homeostasis"], "100911376": ["Olfactory Signaling Pathway"], "100911380": ["Olfactory Signaling Pathway"], "100911398": ["Olfactory Signaling Pathway"], "100911417": ["Formation of ATP by chemiosmotic coupling", "Cristae formation"], "100911440": ["Organic anion transporters"], "100911453": ["RMTs methylate histone arginines"], "100911462": ["mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "100911483": ["Respiratory electron transport", "Complex I biogenesis"], "100911485": ["Pink/Parkin Mediated Mitophagy", "Factors involved in megakaryocyte development and platelet production"], "100911519": ["TP53 Regulates Transcription of Caspase Activators and Caspases"], "100911527": ["Interferon alpha/beta signaling", "Regulation of IFNA signaling"], "100911545": ["Platelet degranulation ", "Intrinsic Pathway of Fibrin Clot Formation", "Degradation of the extracellular matrix", "Rho GTPase cycle", "HDL assembly"], "100911548": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "100911562": ["Scavenging of heme from plasma", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "100911576": ["SUMOylation of RNA binding proteins", "mRNA Splicing - Major Pathway"], "100911581": ["Arachidonic acid metabolism"], "100911586": ["Olfactory Signaling Pathway"], "100911597": ["Regulation of actin dynamics for phagocytic cup formation", "RHO GTPases activate PAKs"], "100911615": ["Acyl chain remodeling of DAG and TAG", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "100911625": ["Gluconeogenesis"], "100911681": ["Formation of the cornified envelope"], "100911685": ["Eukaryotic Translation Termination", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "100911689": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "100911725": ["Glycolysis"], "100911730": ["Assembly of collagen fibrils and other multimeric structures", "Type I hemidesmosome assembly"], "100911734": ["Insulin processing", "VxPx cargo-targeting to cilium"], "100911769": ["Trafficking of AMPA receptors", "Neurexins and neuroligins"], "100911796": ["Adenosine P1 receptors", "G alpha (i) signalling events"], "100911825": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Neutrophil degranulation"], "100911837": ["Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "100911839": ["Olfactory Signaling Pathway"], "100911881": ["Platelet degranulation "], "100911893": ["Olfactory Signaling Pathway"], "100911951": ["Phase 1 - inactivation of fast Na+ channels"], "100911976": ["Sperm:Oocyte Membrane Binding"], "100912012": ["Platelet degranulation "], "100912034": ["G-protein activation", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42"], "100912097": ["Olfactory Signaling Pathway"], "100912115": ["Cargo concentration in the ER"], "100912228": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "100912314": ["Interferon alpha/beta signaling", "Regulation of IFNA signaling"], "100912356": ["Interferon alpha/beta signaling", "Regulation of IFNA signaling"], "100912393": ["mRNA decay by 5' to 3' exoribonuclease", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "KSRP (KHSRP) binds and destabilizes mRNA"], "100912408": ["Olfactory Signaling Pathway"], "100912489": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "SUMOylation of chromatin organization proteins", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "100912505": ["Olfactory Signaling Pathway"], "100912515": ["Olfactory Signaling Pathway"], "100912521": ["Nicotinate metabolism"], "100912534": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase I Transcription Termination", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Pol II CTD phosphorylation and interaction with CE", "Estrogen-dependent gene expression"], "100912540": ["Olfactory Signaling Pathway"], "100912564": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "SUMOylation of chromatin organization proteins", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "100912585": ["ERK/MAPK targets", "Signalling to ERK5", "ERKs are inactivated", "Senescence-Associated Secretory Phenotype (SASP)", "Gastrin-CREB signalling pathway via PKC and MAPK", "RET signaling"], "100912599": ["Respiratory electron transport", "Complex I biogenesis"], "100912604": ["Metabolism of polyamines"], "100912605": ["Olfactory Signaling Pathway"], "100912618": ["NOD1/2 Signaling Pathway", "Downstream TCR signaling", "FCERI mediated NF-kB activation", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "CLEC7A (Dectin-1) signaling", "Interleukin-1 signaling", "IRAK1 recruits IKK complex", "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "Antigen processing: Ubiquitination & Proteasome degradation"], "100912958": ["Olfactory Signaling Pathway"], "100912990": ["Beta defensins", "Defensins"], "102238592": ["Interconversion of nucleotide di- and triphosphates"], "102548286": ["ABC transporters in lipid homeostasis"], "102548514": ["mRNA Splicing - Major Pathway"], "102548682": ["Interleukin-7 signaling", "PRC2 methylates histones and DNA", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "Chromatin modifying enzymes", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression", "Factors involved in megakaryocyte development and platelet production"], "102548693": ["Generic Transcription Pathway"], "102549061": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HATs acetylate histones", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "E3 ubiquitin ligases ubiquitinate target proteins", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "102549173": ["Interleukin-7 signaling", "PRC2 methylates histones and DNA", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "Chromatin modifying enzymes", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression", "Factors involved in megakaryocyte development and platelet production"], "102549542": ["Synthesis of very long-chain fatty acyl-CoAs"], "102549712": ["RNA polymerase II transcribes snRNA genes"], "102550196": ["O-linked glycosylation of mucins"], "102550385": ["Mitochondrial iron-sulfur cluster biogenesis"], "102550892": ["Generic Transcription Pathway"], "102553119": ["Protein methylation"], "102553138": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (q) signalling events"], "102553715": ["Molecules associated with elastic fibres"], "102553866": ["Generic Transcription Pathway"], "102554302": ["Generic Transcription Pathway"], "102554393": ["O-glycosylation of TSR domain-containing proteins"], "102555079": ["Fanconi Anemia Pathway"], "102555083": ["Generic Transcription Pathway"], "102555167": ["Golgi Cisternae Pericentriolar Stack Reorganization", "COPII-mediated vesicle transport", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "102555501": ["Olfactory Signaling Pathway"], "102555599": ["Olfactory Signaling Pathway"], "102556092": ["Generic Transcription Pathway"], "102556119": ["Generic Transcription Pathway"], "102556347": ["Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"], "102556447": ["NRAGE signals death through JNK", "Rho GTPase cycle"], "103689921": ["Coenzyme A biosynthesis"], "103689932": ["GPVI-mediated activation cascade", "Collagen degradation", "Extracellular matrix organization", "Collagen biosynthesis and modifying enzymes", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Assembly of collagen fibrils and other multimeric structures", "Cell surface interactions at the vascular wall", "Integrin cell surface interactions", "Anchoring fibril formation", "Crosslinking of collagen fibrils", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "GP1b-IX-V activation signalling", "Platelet Adhesion to exposed collagen", "Platelet Aggregation (Plug Formation)", "MET activates PTK2 signaling", "Collagen chain trimerization"], "103689936": ["mRNA Splicing - Major Pathway"], "103689940": ["Digestion of dietary carbohydrate"], "103689942": ["Fibronectin matrix formation", "Post-translational modification: synthesis of GPI-anchored proteins", "Cell surface interactions at the vascular wall", "Neutrophil degranulation"], "103689950": ["Cytosolic sulfonation of small molecules"], "103689965": ["Initial triggering of complement", "Activation of C3 and C5", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation", "Regulation of Complement cascade"], "103689974": ["TNFR2 non-canonical NF-kB pathway", "TNFs bind their physiological receptors", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "103689975": ["RNA polymerase II transcribes snRNA genes"], "103689977": ["Caspase-mediated cleavage of cytoskeletal proteins", "Breakdown of the nuclear lamina"], "103689978": ["SUMO is proteolytically processed"], "103689982": ["Acyl chain remodelling of PI"], "103689983": ["Purine salvage"], "103689992": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "103689996": ["ER-Phagosome pathway", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "103689997": ["PD-1 signaling"], "103689999": ["Platelet degranulation "], "103690002": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Deposition of new CENPA-containing nucleosomes at the centromere", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "103690018": ["Golgi Cisternae Pericentriolar Stack Reorganization"], "103690020": ["Platelet degranulation ", "Scavenging by Class B Receptors", "Regulation of TLR by endogenous ligand", "Neutrophil degranulation"], "103690024": ["E3 ubiquitin ligases ubiquitinate target proteins", "Peroxisomal protein import"], "103690036": ["Olfactory Signaling Pathway"], "103690038": ["Generic Transcription Pathway"], "103690044": ["Glutathione conjugation", "Vitamin C (ascorbate) metabolism"], "103690047": ["Glycosphingolipid metabolism", "Sialic acid metabolism"], "103690048": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "103690051": ["HS-GAG biosynthesis"], "103690054": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Transcriptional regulation by small RNAs", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE", "Estrogen-dependent gene expression"], "103690114": ["Generic Transcription Pathway"], "103690116": ["Keratan sulfate biosynthesis", "Keratan sulfate degradation"], "103690156": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "103690163": ["Generic Transcription Pathway"], "103690164": ["Collagen degradation", "Lysine catabolism"], "103690254": ["Collagen degradation", "Activation of Matrix Metalloproteinases", "Cobalamin (Cbl, vitamin B12) transport and metabolism", "Neutrophil degranulation", "Antimicrobial peptides"], "103690280": ["Olfactory Signaling Pathway"], "103690286": ["Olfactory Signaling Pathway"], "103690289": ["Neutrophil degranulation"], "103690317": ["HATs acetylate histones"], "103690375": ["Olfactory Signaling Pathway"], "103690404": ["Regulation of HSF1-mediated heat shock response"], "103690410": ["Olfactory Signaling Pathway"], "103690821": ["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "103691556": ["Signaling by BMP"], "103691744": ["Degradation of cysteine and homocysteine", "Cysteine formation from homocysteine"], "103692165": ["RHO GTPases Activate Rhotekin and Rhophilins"], "103692169": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "103692716": ["Signaling by ERBB2", "Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "Regulation of actin dynamics for phagocytic cup formation", "eNOS activation", "Regulation of PLK1 Activity at G2/M Transition", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "HSF1 activation", "Attenuation phase", "HSF1-dependent transactivation", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Sema3A PAK dependent Axon repulsion", "VEGFA-VEGFR2 Pathway", "VEGFR2 mediated vascular permeability", "Anchoring of the basal body to the plasma membrane", "Neutrophil degranulation", "The role of GTSE1 in G2/M progression after G2 checkpoint", "AURKA Activation by TPX2", "Downregulation of ERBB2 signaling", "ESR-mediated signaling", "Estrogen-dependent gene expression"], "103692785": ["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "103693022": ["Olfactory Signaling Pathway"], "103693219": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "103693375": ["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "103693533": ["Olfactory Signaling Pathway"], "103693563": ["Glucuronidation"], "103693685": ["Olfactory Signaling Pathway"], "103693780": ["Glyoxylate metabolism and glycine degradation", "Lysine catabolism"], "103693822": ["Olfactory Signaling Pathway"], "103694000": ["Neddylation"], "103694169": ["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "103694380": ["TNFR1-induced proapoptotic signaling", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "TNFR1-mediated ceramide production", "TNFR2 non-canonical NF-kB pathway", "TNF signaling"], "103694381": ["TNFR2 non-canonical NF-kB pathway", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "103694404": ["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "103694852": ["Antimicrobial peptides"], "103694855": ["Erythrocytes take up carbon dioxide and release oxygen", "Erythrocytes take up oxygen and release carbon dioxide", "Scavenging of heme from plasma", "Neutrophil degranulation"], "103694857": ["Erythrocytes take up carbon dioxide and release oxygen", "Erythrocytes take up oxygen and release carbon dioxide", "Scavenging of heme from plasma", "Neutrophil degranulation"], "103694865": ["RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "103694874": ["Degradation of the extracellular matrix", "Activation of Matrix Metalloproteinases"], "103694875": ["ABC-family proteins mediated transport"], "103694876": ["RMTs methylate histone arginines", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "103694877": ["Cell surface interactions at the vascular wall", "Neutrophil degranulation"], "103694893": ["Neutrophil degranulation"], "103694902": ["Recognition of DNA damage by PCNA-containing replication complex", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "E3 ubiquitin ligases ubiquitinate target proteins", "Antigen processing: Ubiquitination & Proteasome degradation"], "103694903": ["Inhibition of replication initiation of damaged DNA by RB1/E2F1", "Spry regulation of FGF signaling", "Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "DARPP-32 events", "Degradation of beta-catenin by the destruction complex", "Beta-catenin phosphorylation cascade", "ERK/MAPK targets", "ERKs are inactivated", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "CTLA4 inhibitory signaling", "RHO GTPases Activate Formins", "RAF activation", "Regulation of TP53 Degradation", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Mitotic Prometaphase", "Cyclin D associated events in G1", "Cyclin A/B1/B2 associated events during G2/M transition", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "103694905": ["Serotonin receptors", "G alpha (s) signalling events"], "103694908": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Neutrophil degranulation"], "103694910": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "103695118": ["RNA Polymerase II Pre-transcription Events", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "Estrogen-dependent gene expression"], "108348032": ["Olfactory Signaling Pathway"], "108348039": ["Olfactory Signaling Pathway"], "108348047": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Neutrophil degranulation"], "108348052": ["Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"], "108348055": ["Anchoring of the basal body to the plasma membrane"], "108348062": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "108348064": ["Regulated proteolysis of p75NTR", "NRIF signals cell death from the nucleus", "NOTCH3 Activation and Transmission of Signal to the Nucleus"], "108348065": ["HSF1 activation", "Cilium Assembly"], "108348066": ["TP53 Regulates Transcription of Genes Involved in Cytochrome C Release"], "108348070": ["HDMs demethylate histones"], "108348071": ["Orexin and neuropeptides FF and QRFP bind to their respective receptors", "G alpha (q) signalling events"], "108348072": ["MHC class II antigen presentation"], "108348073": ["Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "108348078": ["Processing of SMDT1"], "108348080": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "108348083": ["Amino acid synthesis and interconversion (transamination)"], "108348085": ["Keratan sulfate biosynthesis", "O-linked glycosylation"], "108348086": ["Mineralocorticoid biosynthesis"], "108348091": ["RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Factors involved in megakaryocyte development and platelet production"], "108348093": ["Phase I - Functionalization of compounds"], "108348095": ["Keratan sulfate biosynthesis", "Keratan sulfate degradation"], "108348096": ["Macroautophagy", "mTOR signalling", "mTORC1-mediated signalling", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Regulation of PTEN gene transcription"], "108348101": ["Stimuli-sensing channels"], "108348108": ["Regulation of HSF1-mediated heat shock response", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Attenuation phase", "HSF1-dependent transactivation", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Neutrophil degranulation"], "108348112": ["RUNX3 regulates p14-ARF"], "108348118": ["Endosomal/Vacuolar pathway", "Antigen processing: Ubiquitination & Proteasome degradation"], "108348120": ["Depolymerisation of the Nuclear Lamina"], "108348122": ["Regulation of TNFR1 signaling"], "108348131": ["Metal ion SLC transporters", "Iron uptake and transport"], "108348136": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "108348139": ["MHC class II antigen presentation"], "108348144": ["Respiratory electron transport", "Complex I biogenesis"], "108348148": ["Glutathione conjugation"], "108348155": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "108348160": ["VLDL assembly", "VLDL clearance"], "108348168": ["Antigen processing: Ubiquitination & Proteasome degradation"], "108348170": ["Negative regulation of TCF-dependent signaling by WNT ligand antagonists"], "108348173": ["RMTs methylate histone arginines", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"], "108348178": ["Endosomal Sorting Complex Required For Transport (ESCRT)"], "108348185": ["Intrinsic Pathway of Fibrin Clot Formation", "GP1b-IX-V activation signalling", "Platelet Adhesion to exposed collagen", "Platelet Aggregation (Plug Formation)"], "108348189": ["Neddylation"], "108348200": ["Amine ligand-binding receptors", "G alpha (s) signalling events"], "108348235": ["Keratinization"], "108348242": ["Olfactory Signaling Pathway"], "108348250": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "108348260": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "108348266": ["Fatty acids", "Xenobiotics", "CYP2E1 reactions"], "108348287": ["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "108348326": ["E3 ubiquitin ligases ubiquitinate target proteins", "Peroxisomal protein import"], "108349290": ["Olfactory Signaling Pathway"], "108349548": ["Activation of G protein gated Potassium channels", "G-protein activation", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42", "Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "108351703": ["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "108351806": ["Generic Transcription Pathway"], "108352221": ["Olfactory Signaling Pathway"], "112400": ["Signaling by ERBB2", "Signaling by ERBB4", "SHC1 events in ERBB2 signaling", "PI3K events in ERBB4 signaling", "SHC1 events in ERBB4 signaling", "PIP3 activates AKT signaling", "GRB7 events in ERBB2 signaling", "Downregulation of ERBB2:ERBB3 signaling", "GRB2 events in ERBB2 signaling", "PI3K events in ERBB2 signaling", "RAF/MAP kinase cascade", "ERBB2 Regulates Cell Motility", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "ERBB2 Activates PTK6 Signaling", "Downregulation of ERBB2 signaling"], "113894": ["NRIF signals cell death from the nucleus", "p75NTR recruits signalling complexes", "NF-kB is activated and signals survival", "Pink/Parkin Mediated Mitophagy", "Interleukin-1 signaling"], "113906": ["HSF1-dependent transactivation"], "113910": ["Post-translational modification: synthesis of GPI-anchored proteins"], "113912": ["Axonal growth inhibition (RHOA activation)"], "113914": ["Amine ligand-binding receptors", "G alpha (s) signalling events"], "113929": ["Transport of Mature mRNA derived from an Intron-Containing Transcript", "SUMOylation of DNA damage response and repair proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of DNA replication proteins"], "113936": ["Metabolism of Angiotensinogen to Angiotensins", "Regulation of Complement cascade"], "113940": ["Neutrophil degranulation"], "113947": ["Platelet degranulation "], "113948": ["BBSome-mediated cargo-targeting to cilium"], "113958": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "113959": ["Peptide ligand-binding receptors", "G alpha (i) signalling events", "Neutrophil degranulation", "Regulation of Complement cascade"], "113961": ["Golgi Cisternae Pericentriolar Stack Reorganization"], "113965": ["Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA"], "113976": ["Synthesis of very long-chain fatty acyl-CoAs"], "114002": ["HS-GAG biosynthesis"], "114004": ["RHO GTPases activate PKNs"], "114005": ["Glycogen synthesis"], "114017": ["Mitochondrial translation elongation"], "114021": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "114023": ["Neutrophil degranulation", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "114024": ["Synthesis of very long-chain fatty acyl-CoAs"], "114031": ["Antagonism of Activin by Follistatin", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "114032": ["Voltage gated Potassium channels"], "114089": ["Synthesis of PIPs at the Golgi membrane", "ARL13B-mediated ciliary trafficking of INPP5E"], "114091": ["Neutrophil degranulation"], "114095": ["Disinhibition of SNARE formation"], "114097": ["Synthesis of 5-eicosatetraenoic acids", "Synthesis of Leukotrienes (LT) and Eoxins (EX)", "Synthesis of Lipoxins (LX)", "Biosynthesis of maresin conjugates in tissue regeneration (MCTR)"], "114098": ["Leukotriene receptors", "G alpha (q) signalling events"], "114099": ["Leukotriene receptors", "G alpha (q) signalling events"], "114100": ["Cholesterol biosynthesis via desmosterol"], "114103": ["Interleukin-3, Interleukin-5 and GM-CSF signaling", "RAF/MAP kinase cascade", "Interleukin receptor SHC signaling"], "114104": ["Glycosphingolipid metabolism"], "114105": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events", "Neutrophil degranulation"], "114106": ["Retinoid metabolism and transport"], "114111": ["Platelet degranulation ", "VEGF ligand-receptor interactions", "VEGF binds to VEGFR leading to receptor dimerization"], "114113": ["COPI-independent Golgi-to-ER retrograde traffic"], "114114": ["Apoptotic execution phase"], "114115": ["Elevation of cytosolic Ca2+ levels", "Platelet homeostasis"], "114117": ["Activation of G protein gated Potassium channels", "G-protein activation", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42", "Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "114118": ["Activation of G protein gated Potassium channels", "G-protein activation", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42", "Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "114119": ["Activation of G protein gated Potassium channels", "G-protein activation", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42", "Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "114120": ["Activation of G protein gated Potassium channels", "G-protein activation", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42", "Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "114123": ["Choline catabolism"], "114124": ["Factors involved in megakaryocyte development and platelet production"], "114203": ["Regulation of KIT signaling", "Factors involved in megakaryocyte development and platelet production"], "114206": ["Retrograde transport at the Trans-Golgi-Network"], "114208": ["Downregulation of SMAD2/3:SMAD4 transcriptional activity"], "114209": ["Alpha-oxidation of phytanate", "Peroxisomal protein import"], "114211": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (i) signalling events"], "114212": ["Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "G2/M DNA damage checkpoint", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex"], "114214": ["Activation of DNA fragmentation factor"], "114215": ["G alpha (s) signalling events", "Relaxin receptors"], "114245": ["HCN channels"], "114483": ["Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "Oncogene Induced Senescence", "Cyclin D associated events in G1", "Regulation of RUNX1 Expression and Activity"], "114487": ["WNT ligand biogenesis and trafficking"], "114489": ["ECM proteoglycans", "O-linked glycosylation", "Regulation of expression of SLITs and ROBOs"], "114490": ["Regulation of gene expression by Hypoxia-inducible Factor", "Activation of the TFAP2 (AP-2) family of transcription factors"], "114491": ["Activation of the TFAP2 (AP-2) family of transcription factors"], "114494": ["G0 and Early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Regulation of APC/C activators between G1/S and early anaphase", "SCF(Skp2)-mediated degradation of p27/p21", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "Ub-specific processing proteases", "Processing of DNA double-strand break ends", "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "Regulation of TP53 Degradation", "G2 Phase", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Cyclin A/B1/B2 associated events during G2/M transition", "p53-Dependent G1 DNA Damage Response", "Cyclin A:Cdk2-associated events at S phase entry"], "114495": ["NOD1/2 Signaling Pathway", "Oxidative Stress Induced Senescence", "activated TAK1 mediates p38 MAPK activation", "PI5P Regulates TP53 Acetylation", "Interleukin-1 signaling"], "114502": ["HATs acetylate histones"], "114508": ["Gluconeogenesis"], "114509": ["ERK/MAPK targets", "Signalling to ERK5", "ERKs are inactivated", "Senescence-Associated Secretory Phenotype (SASP)", "Gastrin-CREB signalling pathway via PKC and MAPK", "RET signaling"], "114514": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "114518": ["Basigin interactions", "Amino acid transport across the plasma membrane"], "114554": ["Synthesis of PIPs at the plasma membrane", "Synthesis of PIPs at the Golgi membrane"], "114558": ["Macroautophagy", "Ub-specific processing proteases"], "114559": ["EGFR downregulation", "NRAGE signals death through JNK", "Rho GTPase cycle", "Ephrin signaling"], "114561": ["PI and PC transport between ER and Golgi membranes"], "114590": ["Cargo recognition for clathrin-mediated endocytosis"], "114592": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA replication proteins", "RHO GTPases Activate Formins", "Regulation of TP53 Activity through Phosphorylation", "Mitotic Prometaphase"], "114593": ["Physiological factors"], "114612": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA 3'-end processing"], "114613": ["Thyroxine biosynthesis", "Organic anion transporters"], "114628": ["ABC transporters in lipid homeostasis"], "114629": ["Multifunctional anion exchangers"], "114630": ["Formation of ATP by chemiosmotic coupling", "Cristae formation"], "114638": ["RAB GEFs exchange GTP for GDP on RABs"], "114700": ["Vitamin D (calciferol) metabolism", "Vitamins"], "114705": ["G alpha (i) signalling events"], "114709": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "114711": ["Sialic acid metabolism"], "114764": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "RHO GTPases Activate Formins", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "AURKA Activation by TPX2"], "114765": ["mRNA Splicing - Major Pathway"], "114766": ["Processing of SMDT1"], "114846": ["Methylation", "Glutathione conjugation", "Vitamin C (ascorbate) metabolism"], "114850": ["WNT ligand biogenesis and trafficking"], "114851": ["SCF(Skp2)-mediated degradation of p27/p21", "AKT phosphorylates targets in the cytosol", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "Cyclin E associated events during G1/S transition ", "Cyclin D associated events in G1", "p53-Dependent G1 DNA Damage Response", "Cyclin A:Cdk2-associated events at S phase entry", "The role of GTSE1 in G2/M progression after G2 checkpoint"], "114856": ["RAF-independent MAPK1/3 activation", "Negative regulation of MAPK pathway"], "114858": ["Signalling to RAS", "RAF/MAP kinase cascade", "RET signaling"], "114860": ["Galactose catabolism"], "115769": ["Signaling by Hippo", "Apoptotic cleavage of cell adhesion  proteins"], "115771": ["TNFR1-induced proapoptotic signaling", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "Ub-specific processing proteases", "Regulation of TP53 Degradation"], "116456": ["Regulation of HSF1-mediated heat shock response"], "116463": ["Estrogen biosynthesis", "Retinoid metabolism and transport"], "116464": ["Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)"], "116466": ["WNT ligand biogenesis and trafficking"], "116468": ["Translesion synthesis by REV1", "Recognition of DNA damage by PCNA-containing replication complex", "Translesion Synthesis by POLH", "Polymerase switching on the C-strand of the telomere", "Activation of ATR in response to replication stress", "PCNA-Dependent Long Patch Base Excision Repair", "Translesion synthesis by POLK", "Translesion synthesis by POLI", "Termination of translesion DNA synthesis", "HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Polymerase switching"], "116469": ["TRP channels"], "116470": ["Serotonin Neurotransmitter Release Cycle", "Norepinephrine Neurotransmitter Release Cycle", "Glutamate Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle", "Acetylcholine Neurotransmitter Release Cycle", "Other interleukin signaling", "LGI-ADAM interactions", "GABA synthesis, release, reuptake and degradation"], "116477": ["Stimuli-sensing channels"], "116479": ["Cell surface interactions at the vascular wall", "Integrin cell surface interactions", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "Tight junction interactions"], "116482": ["Synthesis of PIPs at the ER membrane", "Synthesis of PIPs at the Golgi membrane"], "116489": ["TWIK related potassium channel (TREK)", "Phase 4 - resting membrane potential"], "116491": ["Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)", "Phase 4 - resting membrane potential"], "116500": ["Neutrophil degranulation", "Intra-Golgi traffic"], "116502": ["Activation and oligomerization of BAK protein", "Release of apoptotic factors from the mitochondria"], "116506": ["G alpha (s) signalling events", "Calcitonin-like ligand receptors"], "116509": ["Na+/Cl- dependent neurotransmitter transporters"], "116510": ["Platelet degranulation ", "Activation of Matrix Metalloproteinases", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "116547": ["RHO GTPases Activate NADPH Oxidases", "Neutrophil degranulation", "Metal sequestration by antimicrobial proteins"], "116548": ["NGF processing", "Assembly of active LPL and LIPC lipase complexes"], "116549": ["WNT mediated activation of DVL", "Signal transduction by L1", "Regulation of TP53 Activity through Phosphorylation", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Regulation of PTEN stability and activity"], "116550": ["RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "116552": ["Collagen biosynthesis and modifying enzymes"], "116553": ["Interleukin-4 and Interleukin-13 signaling"], "116555": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA damage response and repair proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of DNA replication proteins", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "116556": ["Inactivation, recovery and regulation of the phototransduction cascade"], "116558": ["Interleukin-9 signaling"], "116560": ["Activation of G protein gated Potassium channels", "Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "116561": ["Gap junction degradation", "Formation of annular gap junctions", "Lysosome Vesicle Biogenesis", "WNT5A-dependent internalization of FZD4", "WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "116562": ["RAF/MAP kinase cascade", "Interleukin-2 signaling", "Interleukin receptor SHC signaling"], "116563": ["Retrograde neurotrophin signalling", "Gap junction degradation", "Formation of annular gap junctions", "MHC class II antigen presentation", "Trafficking of GluR2-containing AMPA receptors", "Recycling pathway of L1", "WNT5A-dependent internalization of FZD4", "WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "VLDLR internalisation and degradation", "LDL clearance"], "116564": ["Physiological factors"], "116569": ["Digestion of dietary carbohydrate"], "116590": ["phospho-PLA2 pathway", "RAF-independent MAPK1/3 activation", "MAPK1 (ERK2) activation", "Spry regulation of FGF signaling", "Golgi Cisternae Pericentriolar Stack Reorganization", "Frs2-mediated activation", "ERK/MAPK targets", "ERKs are inactivated", "Regulation of actin dynamics for phagocytic cup formation", "Senescence-Associated Secretory Phenotype (SASP)", "NCAM signaling for neurite out-growth", "Recycling pathway of L1", "Signal transduction by L1", "Activation of the AP-1 family of transcription factors", "Thrombin signalling through proteinase activated receptors (PARs)", "Negative regulation of FGFR1 signaling", "RHO GTPases Activate WASPs and WAVEs", "RAF/MAP kinase cascade", "MAP2K and MAPK activation", "Negative feedback regulation of MAPK pathway", "Negative regulation of MAPK pathway", "Neutrophil degranulation", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Signal attenuation", "Gastrin-CREB signalling pathway via PKC and MAPK", "Growth hormone receptor signaling"], "116591": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Neutrophil degranulation"], "116595": ["Neurexins and neuroligins"], "116596": ["CD28 dependent PI3K/Akt signaling", "MAP3K8 (TPL2)-dependent MAPK1/3 activation"], "116599": ["Heme degradation"], "116600": ["Presynaptic depolarization and calcium channel opening", "Regulation of insulin secretion", "Phase 0 - rapid depolarisation", "Phase 2 - plateau phase"], "116630": ["Interleukin-3, Interleukin-5 and GM-CSF signaling", "RAF/MAP kinase cascade", "Interleukin receptor SHC signaling"], "116631": ["Acetylation"], "116632": ["Acetylation"], "116636": ["mTORC1-mediated signalling", "Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S"], "116637": ["G alpha (i) signalling events"], "116638": ["Glutamate Neurotransmitter Release Cycle", "Organic anion transporters"], "116639": ["Intra-Golgi traffic"], "116640": ["Integrin cell surface interactions", "ECM proteoglycans", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "116642": ["Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"], "116643": ["Translesion Synthesis by POLH", "HSF1 activation", "ABC-family proteins mediated transport", "N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "Hedgehog ligand biogenesis", "Josephin domain DUBs", "Ovarian tumor domain proteases", "Neutrophil degranulation"], "116647": ["Neurexins and neuroligins"], "116649": ["Activation of G protein gated Potassium channels", "Classical Kir channels", "Phase 4 - resting membrane potential", "Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "116655": ["FGFR2 alternative splicing", "mRNA Splicing - Major Pathway"], "116658": ["Post-translational modification: synthesis of GPI-anchored proteins"], "116659": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Regulation of PLK1 Activity at G2/M Transition", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "AURKA Activation by TPX2"], "116662": ["Platelet degranulation "], "116663": ["RAF-independent MAPK1/3 activation", "ERKs are inactivated", "Negative regulation of MAPK pathway"], "116664": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "116669": ["Platelet degranulation ", "Intrinsic Pathway of Fibrin Clot Formation", "Integrin cell surface interactions", "Integrin alphaIIb beta3 signaling", "GRB2:SOS provides linkage to MAPK signaling for Integrins ", "p130Cas linkage to MAPK signaling for integrins", "GP1b-IX-V activation signalling", "MAP2K and MAPK activation", "Platelet Adhesion to exposed collagen", "Platelet Aggregation (Plug Formation)"], "116670": ["Regulation of PLK1 Activity at G2/M Transition", "RHO GTPases activate PKNs", "RHO GTPases activate PAKs"], "116671": ["CRMPs in Sema3A signaling", "Regulation of TP53 Activity through Phosphorylation"], "116673": ["A tetrasaccharide linker sequence is required for GAG synthesis", "HS-GAG biosynthesis", "HS-GAG degradation", "Cell surface interactions at the vascular wall", "Syndecan interactions", "Retinoid metabolism and transport"], "116676": ["RA biosynthesis pathway"], "116677": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "116680": ["Signaling by SCF-KIT"], "116682": ["Tryptophan catabolism"], "116684": ["Glutathione synthesis and recycling"], "116686": ["Detoxification of Reactive Oxygen Species", "Interconversion of nucleotide di- and triphosphates", "TP53 Regulates Metabolic Genes"], "116690": ["Neurofascin interactions", "Neutrophil degranulation"], "116691": ["Intra-Golgi traffic"], "116694": ["Degradation of the extracellular matrix"], "116695": ["Voltage gated Potassium channels", "Phase 1 - inactivation of fast Na+ channels"], "116696": ["Sialic acid metabolism", "NCAM1 interactions"], "116698": ["Generic Transcription Pathway"], "116699": ["Synthesis of PIPs at the early endosome membrane", "Synthesis of IP2, IP, and Ins in the cytosol"], "116700": ["Androgen biosynthesis", "Mineralocorticoid biosynthesis", "Glycoprotein hormones", "Thyroxine biosynthesis", "Hormone ligand-binding receptors", "G alpha (s) signalling events", "TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "Reactions specific to the complex N-glycan synthesis pathway"], "116718": ["E3 ubiquitin ligases ubiquitinate target proteins", "Peroxisomal protein import"], "116719": ["ChREBP activates metabolic gene expression", "Biotin transport and metabolism", "Import of palmitoyl-CoA into the mitochondrial matrix"], "116724": ["Neurexins and neuroligins"], "116725": ["ISG15 antiviral mechanism", "NOD1/2 Signaling Pathway", "Downstream TCR signaling", "FCERI mediated NF-kB activation", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "CLEC7A (Dectin-1) signaling", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Formation of Incision Complex in GG-NER", "G2/M DNA damage checkpoint", "E3 ubiquitin ligases ubiquitinate target proteins", "Interleukin-1 signaling", "IRAK1 recruits IKK complex", "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "Antigen processing: Ubiquitination & Proteasome degradation"], "116726": ["Basigin interactions", "Amino acid transport across the plasma membrane"], "116727": ["Intrinsic Pathway of Fibrin Clot Formation", "GP1b-IX-V activation signalling", "Platelet Adhesion to exposed collagen", "Platelet Aggregation (Plug Formation)"], "116740": ["O-linked glycosylation of mucins"], "116743": ["Retrograde neurotrophin signalling", "EGFR downregulation", "MHC class II antigen presentation", "Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis", "Recycling pathway of L1", "Negative regulation of MET activity", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "116744": ["G alpha (q) signalling events", "G alpha (i) signalling events", "Lysosphingolipid and LPA receptors"], "116777": ["Adherens junctions interactions"], "116831": ["Ion homeostasis", "Ion transport by P-type ATPases"], "116996": ["Other interleukin signaling"], "117017": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Transcriptional regulation by small RNAs", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE", "Estrogen-dependent gene expression"], "117018": ["Voltage gated Potassium channels", "Phase 3 - rapid repolarisation"], "117022": ["Interleukin-1 signaling"], "117023": ["Voltage gated Potassium channels"], "117028": ["Clathrin-mediated endocytosis"], "117029": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "117033": ["Collagen degradation", "Degradation of the extracellular matrix"], "117035": ["Import of palmitoyl-CoA into the mitochondrial matrix"], "117036": ["Laminin interactions", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "MET activates PTK2 signaling", "Post-translational protein phosphorylation"], "117037": ["Interaction With Cumulus Cells"], "117038": ["Metallothioneins bind metals"], "117039": ["DNA Damage Recognition in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Cargo recognition for clathrin-mediated endocytosis", "Neddylation"], "117041": ["Peptide ligand-binding receptors"], "117042": ["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "117043": ["Macroautophagy", "mTOR signalling", "mTORC1-mediated signalling", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Regulation of PTEN gene transcription"], "117044": ["Macroautophagy", "mTOR signalling", "mTORC1-mediated signalling", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "E3 ubiquitin ligases ubiquitinate target proteins", "Regulation of PTEN gene transcription"], "117045": ["ISG15 antiviral mechanism", "L13a-mediated translational silencing of Ceruloplasmin expression", "mTORC1-mediated signalling", "Deadenylation of mRNA", "Translation initiation complex formation", "Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "117048": ["Adherens junctions interactions"], "117051": ["Retrograde transport at the Trans-Golgi-Network"], "117052": ["Activation of G protein gated Potassium channels", "Classical Kir channels", "Phase 4 - resting membrane potential", "Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "117053": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "117055": ["Gap junction assembly"], "117056": ["PRC2 methylates histones and DNA", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression", "Factors involved in megakaryocyte development and platelet production"], "117058": ["RNA polymerase II transcribes snRNA genes"], "117063": ["Negative regulation of MET activity", "Regulation of IFNG signaling"], "117064": ["G alpha (s) signalling events", "Glucagon-type ligand receptors"], "117089": ["NADE modulates death signalling"], "117098": ["Regulation of pyruvate dehydrogenase (PDH) complex", "Glyoxylate metabolism and glycine degradation", "Signaling by Retinoic Acid", "Pyruvate metabolism"], "117099": ["Synthesis of Ketone Bodies"], "117100": ["Na+/Cl- dependent neurotransmitter transporters", "Creatine metabolism"], "117101": ["Voltage gated Potassium channels"], "117103": ["Regulation of PLK1 Activity at G2/M Transition", "Anchoring of the basal body to the plasma membrane", "VxPx cargo-targeting to cilium", "TBC/RABGAPs", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "117104": ["Cyclin D associated events in G1", "Cyclin A/B1/B2 associated events during G2/M transition", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "117106": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "117108": ["A tetrasaccharide linker sequence is required for GAG synthesis"], "117152": ["Neutrophil degranulation", "Neddylation", "Iron uptake and transport"], "117185": ["Glycosphingolipid metabolism"], "117240": ["Metal ion SLC transporters", "Iron uptake and transport"], "117243": ["Synthesis of very long-chain fatty acyl-CoAs"], "117254": ["Detoxification of Reactive Oxygen Species", "TP53 Regulates Metabolic Genes"], "117255": ["SHC1 events in ERBB2 signaling", "Downregulation of ERBB2 signaling"], "117257": ["G alpha (s) signalling events"], "117259": ["mRNA Splicing - Major Pathway"], "117260": ["Phosphate bond hydrolysis by NUDT proteins"], "117262": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "117263": ["Autodegradation of Cdh1 by Cdh1:APC/C", "N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "117264": ["G alpha (q) signalling events", "P2Y receptors"], "117265": ["Peroxisomal protein import"], "117267": ["Transport and synthesis of PAPS", "Multifunctional anion exchangers"], "117268": ["PTK6 Regulates Proteins Involved in RNA Processing"], "117269": ["ERK/MAPK targets", "CREB phosphorylation", "Senescence-Associated Secretory Phenotype (SASP)", "CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling", "RSK activation", "Gastrin-CREB signalling pathway via PKC and MAPK"], "117273": ["GPVI-mediated activation cascade", "Axonal growth inhibition (RHOA activation)", "Rho GTPase cycle", "PI3K/AKT activation", "Axonal growth stimulation", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "G beta:gamma signalling through PI3Kgamma", "EPHB-mediated forward signaling", "EPHA-mediated growth cone collapse", "PCP/CE pathway", "G alpha (12/13) signalling events", "Sema4D mediated inhibition of cell attachment and migration", "Sema4D induced cell migration and growth-cone collapse", "VEGFA-VEGFR2 Pathway", "RHO GTPases activate PKNs", "RHO GTPases activate CIT", "RHO GTPases activate KTN1", "RHO GTPases Activate ROCKs", "RHO GTPases Activate Formins", "RHO GTPases Activate Rhotekin and Rhophilins", "Ovarian tumor domain proteases", "ERBB2 Regulates Cell Motility", "Neutrophil degranulation", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "SLIT2:ROBO1 increases RHOA activity"], "117274": ["Nuclear Receptor transcription pathway"], "117276": ["Glycolysis"], "117278": ["Cholesterol biosynthesis via desmosterol"], "117279": ["Regulation by c-FLIP", "RIPK1-mediated regulated necrosis", "CASP8 activity is inhibited", "Dimerization of procaspase-8", "TRAIL  signaling"], "117280": ["mRNA Splicing - Major Pathway"], "117281": ["Inhibition of replication initiation of damaged DNA by RB1/E2F1", "Spry regulation of FGF signaling", "Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "DARPP-32 events", "Degradation of beta-catenin by the destruction complex", "Beta-catenin phosphorylation cascade", "ERK/MAPK targets", "ERKs are inactivated", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "CTLA4 inhibitory signaling", "Anchoring of the basal body to the plasma membrane", "RHO GTPases Activate Formins", "RAF activation", "Regulation of TP53 Degradation", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Mitotic Prometaphase", "Cyclin D associated events in G1", "Cyclin A/B1/B2 associated events during G2/M transition", "AURKA Activation by TPX2", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "117282": ["mRNA Splicing - Major Pathway"], "117284": ["Unblocking of NMDA receptors, glutamate binding and activation", "RAF/MAP kinase cascade", "Neutrophil degranulation"], "117287": ["SUMOylation of transcription cofactors"], "117513": ["COPII-mediated vesicle transport"], "117514": ["The NLRP3 inflammasome"], "117515": ["Anchoring of the basal body to the plasma membrane"], "117519": ["Ub-specific processing proteases", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "117522": ["Post-translational modification: synthesis of GPI-anchored proteins"], "117524": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "117526": ["B-WICH complex positively regulates rRNA expression", "RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase I Transcription Termination", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "Estrogen-dependent gene expression"], "117535": ["Regulation of TP53 Activity through Acetylation", "RNA Polymerase I Transcription Initiation", "Regulation of PTEN gene transcription"], "117537": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "117539": ["Interleukin-10 signaling"], "117542": ["Regulation of actin dynamics for phagocytic cup formation", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate WASPs and WAVEs"], "117543": ["mitochondrial fatty acid beta-oxidation of unsaturated fatty acids"], "117544": ["Purine ribonucleoside monophosphate biosynthesis"], "117548": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "117549": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "117550": ["MHC class II antigen presentation", "RHO GTPases activate KTN1", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "117553": ["Dectin-1 mediated noncanonical NF-kB signaling", "NIK-->noncanonical NF-kB signaling", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "117557": ["Striated Muscle Contraction", "Smooth Muscle Contraction"], "117596": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "117955": ["Bicarbonate transporters"], "122772": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "124440": ["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "124461": ["Clathrin-mediated endocytosis"], "140433": ["Laminin interactions", "MET activates PTK2 signaling"], "140448": ["Reduction of cytosolic Ca++ levels", "Sodium/Calcium exchangers", "Ion homeostasis"], "140544": ["Synthesis of PC"], "140547": ["Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA"], "140568": ["Reactions specific to the complex N-glycan synthesis pathway"], "140581": ["Tight junction interactions"], "140584": ["WNT ligand biogenesis and trafficking", "Ca2+ pathway", "PCP/CE pathway"], "140586": ["Deactivation of the beta-catenin transactivating complex", "Transcriptional regulation by RUNX2"], "140589": ["Degradation of GLI1 by the proteasome", "Hedgehog 'off' state", "Hedgehog 'on' state"], "140590": ["Signaling by BMP"], "140592": ["Serotonin Neurotransmitter Release Cycle", "Norepinephrine Neurotransmitter Release Cycle", "Glutamate Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle", "Acetylcholine Neurotransmitter Release Cycle", "Receptor-type tyrosine-protein phosphatases"], "140593": ["Netrin-1 signaling", "Ub-specific processing proteases", "Antigen processing: Ubiquitination & Proteasome degradation"], "140594": ["Platelet degranulation "], "140595": ["G alpha (s) signalling events"], "140607": ["Synthesis of PIPs at the plasma membrane", "PI5P Regulates TP53 Acetylation", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Synthesis of PIPs in the nucleus"], "140608": ["Formation of ATP by chemiosmotic coupling", "Cristae formation"], "140638": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation", "Chylomicron remodeling"], "140654": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "140655": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "140656": ["Platelet degranulation ", "Neutrophil degranulation"], "140661": ["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "140665": ["Neutrophil degranulation", "RAB geranylgeranylation"], "140668": ["Recycling of bile acids and salts", "ABC-family proteins mediated transport"], "140669": ["Mitochondrial ABC transporters"], "140670": ["Retrograde neurotrophin signalling", "MHC class II antigen presentation", "Trafficking of GluR2-containing AMPA receptors", "Recycling pathway of L1", "WNT5A-dependent internalization of FZD4", "WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "VLDLR internalisation and degradation", "LDL clearance"], "140671": ["Glycogen breakdown (glycogenolysis)"], "140673": ["COPII-mediated vesicle transport", "Golgi Associated Vesicle Biogenesis", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network"], "140675": ["GABA A receptor activation"], "140693": ["Synthesis of IP3 and IP4 in the cytosol"], "140694": ["Gap junction degradation", "Formation of annular gap junctions", "MHC class II antigen presentation", "Recycling pathway of L1", "Clathrin-mediated endocytosis"], "140724": ["Trafficking of AMPA receptors", "Phase 0 - rapid depolarisation", "Phase 2 - plateau phase", "LGI-ADAM interactions"], "140725": ["Presynaptic depolarization and calcium channel opening", "Trafficking of AMPA receptors", "Phase 0 - rapid depolarisation", "Phase 2 - plateau phase", "LGI-ADAM interactions"], "140726": ["Phase 0 - rapid depolarisation", "Phase 2 - plateau phase"], "140727": ["Phase 0 - rapid depolarisation", "Phase 2 - plateau phase"], "140728": ["Phase 0 - rapid depolarisation", "Phase 2 - plateau phase"], "140734": ["Activation of BMF and translocation to mitochondria", "Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Macroautophagy", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Intraflagellar transport", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase"], "140808": ["N-glycan trimming and elongation in the cis-Golgi"], "140860": ["Transport of organic anions"], "140866": ["Effects of PIP2 hydrolysis"], "140868": ["Triglyceride catabolism", "Signaling by Retinoic Acid", "Neutrophil degranulation"], "140898": ["NRAGE signals death through JNK", "Rho GTPase cycle"], "140908": ["DARPP-32 events", "CRMPs in Sema3A signaling", "Regulation of TP53 Activity through Phosphorylation"], "140910": ["Cholesterol biosynthesis"], "140914": ["Cell surface interactions at the vascular wall", "Neutrophil degranulation"], "140915": ["Transport of organic anions"], "140924": ["Interleukin-7 signaling", "RAF/MAP kinase cascade", "Interleukin-4 and Interleukin-13 signaling", "Interleukin-15 signaling", "Interleukin-9 signaling", "Interleukin-2 signaling", "Interleukin-21 signaling", "Interleukin receptor SHC signaling"], "140926": ["SUMOylation of transcription cofactors", "Regulation of TP53 Degradation"], "140928": ["cGMP effects", "G alpha (s) signalling events"], "140929": ["G alpha (s) signalling events"], "140932": ["COPI-dependent Golgi-to-ER retrograde traffic"], "140933": ["TRP channels"], "140939": ["Antigen processing: Ubiquitination & Proteasome degradation"], "140941": ["Netrin-1 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "140944": ["Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"], "140945": ["Synaptic adhesion-like molecules"], "140946": ["Purine ribonucleoside monophosphate biosynthesis"], "155012": ["Regulation of Complement cascade"], "155140": ["Interleukin-23 signaling"], "155183": ["Signal regulatory protein family interactions"], "155192": ["ABC transporters in lipid homeostasis"], "155205": ["Amino acid transport across the plasma membrane", "Proton-coupled neutral amino acid transporters"], "155812": ["Antigen processing: Ubiquitination & Proteasome degradation"], "155918": ["GPVI-mediated activation cascade", "Generation of second messenger molecules", "DAP12 signaling", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization"], "156275": ["Aflatoxin activation and detoxification"], "156767": ["TNFR2 non-canonical NF-kB pathway", "TNFs bind their physiological receptors", "Neutrophil degranulation"], "156826": ["Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"], "156873": ["Phase 4 - resting membrane potential"], "157074": ["Citric acid cycle (TCA cycle)"], "161452": ["Formation of the beta-catenin:TCF transactivating complex", "Deactivation of the beta-catenin transactivating complex", "Ca2+ pathway", "Repression of WNT target genes", "RUNX3 regulates WNT signaling"], "161477": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "170501": ["O-linked glycosylation of mucins"], "170520": ["eNOS activation", "Intracellular oxygen transport"], "170551": ["Vitamin B5 (pantothenate) metabolism", "Transport of vitamins, nucleosides, and related molecules"], "170566": ["Amino acid transport across the plasma membrane"], "170567": ["Astrocytic Glutamate-Glutamine Uptake And Metabolism", "Amino acid transport across the plasma membrane"], "170573": ["Amino acid transport across the plasma membrane"], "170579": ["PI3K Cascade", "PIP3 activates AKT signaling", "FGFR1b ligand binding and activation", "FGFR2b ligand binding and activation", "Phospholipase C-mediated cascade: FGFR1", "Phospholipase C-mediated cascade; FGFR2", "Downstream signaling of activated FGFR1", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "FGFRL1 modulation of FGFR1 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "170580": ["Cellular hexose transport"], "170582": ["PI3K Cascade", "PIP3 activates AKT signaling", "betaKlotho-mediated ligand binding", "FGFR4 ligand binding and activation", "Phospholipase C-mediated cascade; FGFR4", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "PI-3K cascade:FGFR4", "Negative regulation of FGFR4 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "170583": ["PI3K Cascade", "PIP3 activates AKT signaling", "FGFR4 ligand binding and activation", "FGFR3c ligand binding and activation", "FGFR1c ligand binding and activation", "FGFR1c and Klotho ligand binding and activation", "FGFR2c ligand binding and activation", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Phospholipase C-mediated cascade: FGFR1", "Phospholipase C-mediated cascade; FGFR2", "Phospholipase C-mediated cascade; FGFR3", "Phospholipase C-mediated cascade; FGFR4", "Downstream signaling of activated FGFR1", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "PI-3K cascade:FGFR3", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "PI-3K cascade:FGFR4", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "FGFRL1 modulation of FGFR1 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Post-translational protein phosphorylation"], "170588": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Beta-oxidation of pristanoyl-CoA", "Beta-oxidation of very long chain fatty acids", "Peroxisomal protein import"], "170630": ["Phase 0 - rapid depolarisation"], "170633": ["PI3K Cascade", "PIP3 activates AKT signaling", "FGFR1b ligand binding and activation", "FGFR2b ligand binding and activation", "Phospholipase C-mediated cascade: FGFR1", "Phospholipase C-mediated cascade; FGFR2", "Downstream signaling of activated FGFR1", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "FGFRL1 modulation of FGFR1 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "170634": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "170635": ["The canonical retinoid cycle in rods (twilight vision)", "RA biosynthesis pathway"], "170667": ["ROS, RNS production in phagocytes", "Neutrophil degranulation", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "170670": ["Acyl chain remodeling of CL", "Beta oxidation of myristoyl-CoA to lauroyl-CoA"], "170672": ["Nephrin family interactions"], "170698": ["Recycling of bile acids and salts", "Transport of organic anions"], "170700": ["PI3K Cascade", "PIP3 activates AKT signaling", "FGFR4 ligand binding and activation", "FGFR1c ligand binding and activation", "FGFR2c ligand binding and activation", "Phospholipase C-mediated cascade: FGFR1", "Phospholipase C-mediated cascade; FGFR2", "Phospholipase C-mediated cascade; FGFR4", "Downstream signaling of activated FGFR1", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "PI-3K cascade:FGFR4", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR4 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "170714": ["Intraflagellar transport"], "170808": ["Degradation of the extracellular matrix"], "170816": ["Olfactory Signaling Pathway"], "170818": ["Gamma carboxylation, hypusine formation and arylsulfatase activation"], "170819": ["Interleukin-20 family signaling"], "170840": ["Metal ion SLC transporters", "Iron uptake and transport"], "170841": ["Cleavage of the damaged purine", "Displacement of DNA glycosylase by APEX1"], "170843": ["PTK6 Regulates Proteins Involved in RNA Processing"], "170844": ["RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "170845": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "170847": ["Activation of G protein gated Potassium channels", "Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "170896": ["Class B/2 (Secretin family receptors)"], "170897": ["Sphingolipid de novo biosynthesis", "Association of TriC/CCT with target proteins during biosynthesis", "VEGFR2 mediated cell proliferation"], "170898": ["Carnitine synthesis"], "170899": ["TWIK related potassium channel (TREK)", "Phase 4 - resting membrane potential"], "170900": ["RUNX2 regulates bone development"], "170907": ["Serine biosynthesis"], "170911": ["PI3K Cascade", "IRS-mediated signalling", "GPVI-mediated activation cascade", "PI3K events in ERBB4 signaling", "PIP3 activates AKT signaling", "Signaling by SCF-KIT", "Synthesis of PIPs at the plasma membrane", "GAB1 signalosome", "Downstream signal transduction", "PI3K events in ERBB2 signaling", "PI3K/AKT activation", "Downstream TCR signaling", "Role of phospholipids in phagocytosis", "Tie2 Signaling", "DAP12 signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Costimulation by the CD28 family", "CD28 dependent PI3K/Akt signaling", "G alpha (q) signalling events", "VEGFA-VEGFR2 Pathway", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "PI-3K cascade:FGFR1", "PI-3K cascade:FGFR2", "PI-3K cascade:FGFR3", "PI-3K cascade:FGFR4", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "MET activates PI3K/AKT signaling", "RET signaling", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "Interleukin receptor SHC signaling", "Regulation of signaling by CBL"], "170913": ["ABC-family proteins mediated transport"], "170919": ["Synthesis of PA"], "170921": ["Integrin cell surface interactions", "Laminin interactions", "Syndecan interactions", "ECM proteoglycans", "MET activates PTK2 signaling"], "170922": ["Localization of the PINCH-ILK-PARVIN complex to focal adhesions"], "170923": ["Neutrophil degranulation"], "170926": ["Leukotriene receptors", "G alpha (q) signalling events"], "170933": ["mRNA Splicing - Major Pathway"], "170943": ["Organic anion transporters", "Gluconeogenesis"], "170945": ["Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "Highly calcium permeable nicotinic acetylcholine receptors"], "170955": ["Generic Transcription Pathway"], "171009": ["Striated Muscle Contraction"], "171015": ["Erythrocytes take up carbon dioxide and release oxygen"], "171016": ["Platelet degranulation ", "Dissolution of Fibrin Clot"], "171026": ["Trafficking of AMPA receptors", "ROBO receptors bind AKAP5"], "171028": ["Ion transport by P-type ATPases"], "171040": ["IL-6-type cytokine receptor ligand interactions"], "171041": ["MHC class II antigen presentation", "RHO GTPases activate KTN1", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "171044": ["Peptide ligand-binding receptors", "G alpha (i) signalling events", "BBSome-mediated cargo-targeting to cilium"], "171047": ["Purine catabolism"], "171049": ["COPII-mediated vesicle transport", "Cargo concentration in the ER", "COPI-mediated anterograde transport"], "171052": ["Collagen degradation", "Degradation of the extracellular matrix", "Activation of Matrix Metalloproteinases", "Assembly of collagen fibrils and other multimeric structures"], "171055": ["CD22 mediated BCR regulation", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "171056": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "171058": ["RAB geranylgeranylation"], "171060": ["Interleukin-4 and Interleukin-13 signaling"], "171061": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "171068": ["RNA polymerase II transcribes snRNA genes", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "Estrogen-dependent gene expression"], "171072": ["Cytosolic sulfonation of small molecules"], "171082": ["Formation of ATP by chemiosmotic coupling", "Cristae formation"], "171088": ["Synthesis of PIPs at the plasma membrane", "Synthesis of IP2, IP, and Ins in the cytosol", "Synthesis of IP3 and IP4 in the cytosol"], "171101": ["Peptide ligand-binding receptors", "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "G alpha (q) signalling events"], "171104": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "171105": ["Endosomal/Vacuolar pathway", "Antigen processing: Ubiquitination & Proteasome degradation"], "171106": ["Interleukin-38 signaling", "Interleukin-36 pathway"], "171108": ["P2Y receptors", "G alpha (i) signalling events"], "171111": ["RAB geranylgeranylation"], "171116": ["Regulation of Apoptosis"], "171121": ["COPII-mediated vesicle transport"], "171122": ["RAB geranylgeranylation"], "171128": ["Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation"], "171131": ["Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "Highly calcium permeable nicotinic acetylcholine receptors"], "171133": ["Glyoxylate metabolism and glycine degradation", "Glycine degradation"], "171135": ["Metal ion SLC transporters"], "171136": ["Antigen processing: Ubiquitination & Proteasome degradation"], "171137": ["KSRP (KHSRP) binds and destabilizes mRNA"], "171138": ["Phase 3 - rapid repolarisation", "Phase 2 - plateau phase"], "171140": ["HSF1-dependent transactivation", "Trafficking of AMPA receptors", "Unblocking of NMDA receptors, glutamate binding and activation", "Phase 0 - rapid depolarisation", "Ion homeostasis", "RAF activation", "Interferon gamma signaling", "Ion transport by P-type ATPases"], "171142": ["Beta-oxidation of very long chain fatty acids", "Peroxisomal protein import"], "171144": ["Transport of organic anions"], "171145": ["Recycling of eIF2:GDP"], "171146": ["Voltage gated Potassium channels"], "171147": ["Inositol transporters"], "171148": ["Na+/Cl- dependent neurotransmitter transporters"], "171152": ["Ub-specific processing proteases", "RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "171154": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "171155": ["Acyl chain remodeling of CL", "Beta oxidation of myristoyl-CoA to lauroyl-CoA"], "171158": ["Hormone ligand-binding receptors", "G alpha (s) signalling events"], "171162": ["Antimicrobial peptides"], "171163": ["Na+/Cl- dependent neurotransmitter transporters", "Reuptake of GABA"], "171287": ["EPH-Ephrin signaling", "EPHA-mediated growth cone collapse", "EPH-ephrin mediated repulsion of cells"], "171290": ["Activation, myristolyation of BID and translocation to mitochondria"], "171293": ["Collagen degradation", "Metabolism of Angiotensinogen to Angiotensins", "MHC class II antigen presentation", "Neutrophil degranulation"], "171297": ["Neurexins and neuroligins"], "171304": ["MHC class II antigen presentation", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "171333": ["Interleukin-12 signaling", "Interleukin-23 signaling"], "171334": ["Interleukin-35 Signalling", "Interleukin-12 signaling"], "171341": ["Glutathione conjugation", "Neutrophil degranulation"], "171350": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Deadenylation of mRNA", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Translation initiation complex formation", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "171355": ["Regulation of TP53 Activity through Association with Co-factors"], "171365": ["Cleavage of Growing Transcript in the Termination Region ", "SLBP independent Processing of Histone Pre-mRNAs", "snRNP Assembly", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"], "171366": ["Processing of DNA double-strand break ends"], "171369": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "TNFR2 non-canonical NF-kB pathway", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "171375": ["Formation of ATP by chemiosmotic coupling", "Cristae formation"], "171378": ["Activation of BAD and translocation to mitochondria "], "171379": ["Interleukin-7 signaling", "Formation of the beta-catenin:TCF transactivating complex", "RMTs methylate histone arginines", "Chromatin modifying enzymes", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "171384": ["TRP channels"], "171400": ["Linoleic acid (LA) metabolism", "Synthesis of very long-chain fatty acyl-CoAs"], "171402": ["Synthesis of very long-chain fatty acyl-CoAs"], "171408": ["Formation of xylulose-5-phosphate"], "171409": ["Striated Muscle Contraction"], "171410": ["Synthesis of very long-chain fatty acyl-CoAs"], "171412": ["Beta defensins", "Defensins"], "171415": ["Macroautophagy"], "171433": ["Mitochondrial calcium ion transport", "Processing of SMDT1"], "171451": ["Phase I - Functionalization of compounds"], "171455": ["Insulin processing", "VxPx cargo-targeting to cilium"], "171458": ["Synthesis of IPs in the nucleus"], "171459": ["Post-translational modification: synthesis of GPI-anchored proteins"], "171499": ["Interleukin-7 signaling"], "171503": ["Activation of RAC1 downstream of NMDARs"], "171516": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "RA biosynthesis pathway", "Retinoid metabolism and transport"], "171517": ["A tetrasaccharide linker sequence is required for GAG synthesis", "HS-GAG biosynthesis", "HS-GAG degradation", "Retinoid metabolism and transport"], "171519": ["G alpha (s) signalling events", "Calcitonin-like ligand receptors"], "171522": ["Fatty acids", "Miscellaneous substrates", "Xenobiotics", "CYP2E1 reactions", "Biosynthesis of maresin-like SPMs"], "171528": ["Activation, myristolyation of BID and translocation to mitochondria"], "171529": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "COPI-dependent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "Kinesins"], "171547": ["Neutrophil degranulation"], "171549": ["MHC class II antigen presentation", "RHO GTPases activate KTN1", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "171551": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events", "Neutrophil degranulation"], "171562": ["Insulin processing", "Detoxification of Reactive Oxygen Species"], "171565": ["Metalloprotease DUBs"], "171569": ["O-glycosylation of TSR domain-containing proteins"], "171571": ["Trafficking of GluR2-containing AMPA receptors"], "171574": ["MHC class II antigen presentation", "Recycling pathway of L1", "Clathrin-mediated endocytosis"], "171575": ["Lysosome Vesicle Biogenesis"], "171577": ["Cell surface interactions at the vascular wall"], "171581": ["Rho GTPase cycle"], "191569": ["cGMP effects"], "191574": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "RA biosynthesis pathway", "Retinoid metabolism and transport"], "191575": ["Interconversion of nucleotide di- and triphosphates"], "191576": ["Synthesis of very long-chain fatty acyl-CoAs"], "192117": ["Regulation of RAS by GAPs"], "192126": ["Regulation of RAS by GAPs"], "192152": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Golgi Associated Vesicle Biogenesis", "Retrograde transport at the Trans-Golgi-Network", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "Post-translational protein phosphorylation"], "192154": ["Clathrin-mediated endocytosis"], "192172": ["Degradation of cysteine and homocysteine"], "192178": ["Post-transcriptional silencing by small RNAs"], "192183": ["Adherens junctions interactions", "Nectin/Necl  trans heterodimerization"], "192205": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "192206": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "192208": ["Amino acid transport across the plasma membrane"], "192223": ["G alpha (q) signalling events", "Opsins"], "192228": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "192234": ["Recycling of eIF2:GDP"], "192241": ["Formation of ATP by chemiosmotic coupling", "Cristae formation"], "192242": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol"], "192243": ["Golgi Associated Vesicle Biogenesis", "COPI-mediated anterograde transport"], "192246": ["mRNA Splicing - Major Pathway"], "192248": ["Adherens junctions interactions"], "192249": ["Factors involved in megakaryocyte development and platelet production"], "192256": ["Antigen processing: Ubiquitination & Proteasome degradation"], "192258": ["GABA A (rho) receptor activation"], "192260": ["Synthesis of PI"], "192263": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "192264": ["Neutrophil degranulation", "Antimicrobial peptides"], "192268": ["Glutamate Neurotransmitter Release Cycle", "TP53 Regulates Metabolic Genes", "Amino acid synthesis and interconversion (transamination)"], "192270": ["Sphingolipid de novo biosynthesis"], "192272": ["Mitochondrial Fatty Acid Beta-Oxidation", "Peroxisomal protein import"], "192277": ["HSP90 chaperone cycle for steroid hormone receptors (SHR)"], "192350": ["TP53 Regulates Transcription of DNA Repair Genes"], "192351": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "192357": ["Purine salvage"], "192362": ["Degradation of the extracellular matrix", "Assembly of collagen fibrils and other multimeric structures", "Anchoring fibril formation", "Laminin interactions", "Type I hemidesmosome assembly", "MET activates PTK2 signaling"], "192648": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "192649": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "192675": ["Stimuli-sensing channels"], "207113": ["Post-translational modification: synthesis of GPI-anchored proteins"], "207122": ["RHO GTPases activate PKNs"], "24153": ["Platelet degranulation ", "Intrinsic Pathway of Fibrin Clot Formation", "Degradation of the extracellular matrix", "Rho GTPase cycle", "HDL assembly"], "24158": ["Beta oxidation of octanoyl-CoA to hexanoyl-CoA"], "24159": ["ChREBP activates metabolic gene expression", "Neutrophil degranulation", "Fatty acyl-CoA biosynthesis"], "24163": ["Acrosome Reaction"], "24165": ["Purine salvage"], "24166": ["G alpha (s) signalling events", "Glucagon-type ligand receptors"], "24167": ["G alpha (s) signalling events", "Glucagon-type ligand receptors"], "24171": ["Miscellaneous transport and binding events"], "24172": ["Abacavir metabolism", "RA biosynthesis pathway", "Ethanol oxidation"], "24174": ["Adrenoceptors", "Adrenaline signalling through Alpha-2 adrenergic receptor", "G alpha (i) signalling events", "G alpha (z) signalling events"], "24175": ["Adrenoceptors", "Adrenaline signalling through Alpha-2 adrenergic receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "G alpha (i) signalling events", "G alpha (z) signalling events", "Surfactant metabolism"], "24176": ["Adrenoceptors", "G alpha (s) signalling events", "Ub-specific processing proteases", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "24177": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "24179": ["Metabolism of Angiotensinogen to Angiotensins", "Peptide ligand-binding receptors", "G alpha (q) signalling events", "G alpha (i) signalling events"], "24180": ["Peptide ligand-binding receptors", "G alpha (q) signalling events", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "24182": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "24184": ["Interconversion of nucleotide di- and triphosphates"], "24185": ["PIP3 activates AKT signaling", "Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "mTOR signalling", "AKT phosphorylates targets in the cytosol", "AKT phosphorylates targets in the nucleus", "Negative regulation of the PI3K/AKT network", "eNOS activation", "Integrin alphaIIb beta3 signaling", "Deactivation of the beta-catenin transactivating complex", "CD28 dependent PI3K/Akt signaling", "CTLA4 inhibitory signaling", "G beta:gamma signalling through PI3Kgamma", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "VEGFR2 mediated vascular permeability", "Regulation of TP53 Degradation", "Regulation of TP53 Activity through Acetylation", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1"], "24186": ["Platelet degranulation ", "Recycling of bile acids and salts", "Scavenging of heme from plasma", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Transport of organic anions", "Post-translational protein phosphorylation", "HDL remodeling"], "24189": ["Platelet degranulation ", "Neutrophil degranulation", "Gluconeogenesis"], "24190": ["Gluconeogenesis", "Fructose catabolism"], "24191": ["Neutrophil degranulation", "Gluconeogenesis"], "24192": ["Pregnenolone biosynthesis"], "24197": ["Synthesis of PA", "Post-translational modification: synthesis of GPI-anchored proteins", "Intra-Golgi traffic", "Digestion"], "24205": ["Apoptotic cleavage of cellular proteins", "Degradation of beta-catenin by the destruction complex", "Beta-catenin phosphorylation cascade", "Deactivation of the beta-catenin transactivating complex", "Ovarian tumor domain proteases"], "24207": ["Chylomicron assembly", "Chylomicron remodeling", "HDL remodeling", "Retinoid metabolism and transport"], "24210": ["Asparagine N-linked glycosylation"], "24211": ["Ion homeostasis", "Ion transport by P-type ATPases"], "24212": ["Ion homeostasis", "Ion transport by P-type ATPases"], "24213": ["Ion homeostasis", "Ion transport by P-type ATPases"], "24214": ["Basigin interactions", "Ion homeostasis", "Ion transport by P-type ATPases"], "24215": ["Reduction of cytosolic Ca++ levels", "Ion homeostasis", "Ion transport by P-type ATPases"], "24217": ["Ion transport by P-type ATPases"], "24218": ["Ion transport by P-type ATPases"], "24221": ["Vasopressin-like receptors", "G alpha (q) signalling events", "G alpha (s) signalling events", "Vasopressin regulates renal water homeostasis via Aquaporins", "Transport of organic anions", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "24223": ["ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "DAP12 interactions", "DAP12 signaling", "Neutrophil degranulation", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "24225": ["Activated NTRK2 signals through PLCG1", "Activated NTRK2 signals through FRS2 and FRS3", "NTRK2 activates RAC1"], "24230": ["Pregnenolone biosynthesis"], "24231": ["Initial triggering of complement", "Activation of C3 and C5", "Regulation of Complement cascade"], "24232": ["Alternative complement activation", "Activation of C3 and C5", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Peptide ligand-binding receptors", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "G alpha (i) signalling events", "Neutrophil degranulation", "Post-translational protein phosphorylation", "Regulation of Complement cascade"], "24241": ["G alpha (s) signalling events", "Calcitonin-like ligand receptors"], "24242": ["CaMK IV-mediated phosphorylation of CREB", "Calmodulin induced events", "Cam-PDE 1 activation", "Platelet degranulation ", "Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "PKA activation", "Synthesis of IP3 and IP4 in the cytosol", "Calcineurin activates NFAT", "eNOS activation", "Inactivation, recovery and regulation of the phototransduction cascade", "Stimuli-sensing channels", "FCERI mediated Ca+2 mobilization", "Ca2+ pathway", "Reduction of cytosolic Ca++ levels", "Sodium/Calcium exchangers", "Unblocking of NMDA receptors, glutamate binding and activation", "CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "Smooth Muscle Contraction", "Activation of Ca-permeable Kainate Receptor", "VEGFR2 mediated vascular permeability", "Phase 0 - rapid depolarisation", "Ion homeostasis", "CLEC7A (Dectin-1) induces NFAT activation", "RHO GTPases activate IQGAPs", "RHO GTPases activate PAKs", "RAF activation", "RAF/MAP kinase cascade", "Glycogen breakdown (glycogenolysis)", "Protein methylation", "Ion transport by P-type ATPases", "Activation of RAC1 downstream of NMDARs", "Long-term potentiation"], "24244": ["CaMK IV-mediated phosphorylation of CREB", "Calmodulin induced events", "Cam-PDE 1 activation", "Platelet degranulation ", "Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "PKA activation", "Synthesis of IP3 and IP4 in the cytosol", "Calcineurin activates NFAT", "eNOS activation", "Inactivation, recovery and regulation of the phototransduction cascade", "Stimuli-sensing channels", "FCERI mediated Ca+2 mobilization", "Ca2+ pathway", "Reduction of cytosolic Ca++ levels", "Sodium/Calcium exchangers", "Unblocking of NMDA receptors, glutamate binding and activation", "CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "Smooth Muscle Contraction", "Activation of Ca-permeable Kainate Receptor", "VEGFR2 mediated vascular permeability", "Phase 0 - rapid depolarisation", "Ion homeostasis", "CLEC7A (Dectin-1) induces NFAT activation", "RHO GTPases activate IQGAPs", "RHO GTPases activate PAKs", "RAF activation", "RAF/MAP kinase cascade", "Glycogen breakdown (glycogenolysis)", "Protein methylation", "Ion transport by P-type ATPases", "Activation of RAC1 downstream of NMDARs", "Long-term potentiation"], "24245": ["HSF1-dependent transactivation", "Trafficking of AMPA receptors", "Unblocking of NMDA receptors, glutamate binding and activation", "Phase 0 - rapid depolarisation", "Ion homeostasis", "RAF activation", "Interferon gamma signaling", "Ion transport by P-type ATPases"], "24246": ["HSF1-dependent transactivation", "Trafficking of AMPA receptors", "Unblocking of NMDA receptors, glutamate binding and activation", "Phase 0 - rapid depolarisation", "Ion homeostasis", "RAF activation", "Interferon gamma signaling", "Ion transport by P-type ATPases"], "24247": ["G alpha (q) signalling events", "G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "24248": ["Detoxification of Reactive Oxygen Species", "Neutrophil degranulation", "Peroxisomal protein import"], "24250": ["Cysteine formation from homocysteine"], "24251": ["Neutrophil degranulation"], "24253": ["Senescence-Associated Secretory Phenotype (SASP)"], "24258": ["Antimicrobial peptides"], "24259": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "24260": ["Muscarinic acetylcholine receptors", "G alpha (q) signalling events"], "24264": ["Creatine metabolism"], "24265": ["Creatine metabolism"], "24267": ["Methylation", "Enzymatic degradation of dopamine by COMT"], "24268": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Metal ion SLC transporters", "Post-translational protein phosphorylation", "Iron uptake and transport"], "24296": ["Xenobiotics", "Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)", "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)", "Biosynthesis of protectins"], "24297": ["Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2", "Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)", "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)", "Aflatoxin activation and detoxification", "Biosynthesis of protectins", "Biosynthesis of maresin-like SPMs"], "24298": ["Mineralocorticoid biosynthesis", "Endogenous sterols"], "24300": ["Fatty acids", "Xenobiotics", "CYP2E1 reactions"], "24303": ["Fatty acids", "Miscellaneous substrates", "Xenobiotics", "CYP2E1 reactions", "Biosynthesis of maresin-like SPMs"], "24306": ["Fatty acids", "Miscellaneous substrates", "Eicosanoids", "Synthesis of Leukotrienes (LT) and Eoxins (EX)", "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)"], "24307": ["Fatty acids", "Miscellaneous substrates", "Eicosanoids", "Synthesis of Leukotrienes (LT) and Eoxins (EX)"], "24311": ["Serotonin and melatonin biosynthesis"], "24312": ["Metabolism of folate and pterines"], "24314": ["Regulation of ornithine decarboxylase (ODC)"], "24316": ["Dopamine receptors", "G alpha (s) signalling events"], "24318": ["Dopamine receptors", "G alpha (i) signalling events"], "24323": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "24324": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "24326": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "24332": ["Formation of the cornified envelope"], "24333": ["Gluconeogenesis"], "24334": ["Gluconeogenesis"], "24335": ["Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "Erythropoietin activates RAS"], "24336": ["Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "Erythropoietin activates RAS"], "24337": ["Signaling by ERBB2", "SHC1 events in ERBB2 signaling", "PIP3 activates AKT signaling", "GRB7 events in ERBB2 signaling", "Downregulation of ERBB2:ERBB3 signaling", "GRB2 events in ERBB2 signaling", "PI3K events in ERBB2 signaling", "Sema4D induced cell migration and growth-cone collapse", "RAF/MAP kinase cascade", "ERBB2 Regulates Cell Motility", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "ERBB2 Activates PTK6 Signaling", "Downregulation of ERBB2 signaling"], "24338": ["EPH-Ephrin signaling", "EPHB-mediated forward signaling", "Ephrin signaling", "EPH-ephrin mediated repulsion of cells"], "24356": ["Oncogene Induced Senescence"], "24360": ["Triglyceride catabolism", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)"], "24361": ["Fanconi Anemia Pathway"], "24366": ["Platelet degranulation ", "Common Pathway of Fibrin Clot Formation", "Integrin cell surface interactions", "Integrin alphaIIb beta3 signaling", "GRB2:SOS provides linkage to MAPK signaling for Integrins ", "p130Cas linkage to MAPK signaling for integrins", "MAP2K and MAPK activation"], "24367": ["Platelet degranulation ", "Common Pathway of Fibrin Clot Formation", "Integrin cell surface interactions", "Integrin alphaIIb beta3 signaling", "GRB2:SOS provides linkage to MAPK signaling for Integrins ", "p130Cas linkage to MAPK signaling for integrins", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "MAP2K and MAPK activation", "Post-translational protein phosphorylation"], "24368": ["Citric acid cycle (TCA cycle)"], "24370": ["FOXO-mediated transcription of cell cycle genes"], "24373": ["Antagonism of Activin by Follistatin"], "24375": ["Neutrophil degranulation", "Reactions specific to the complex N-glycan synthesis pathway"], "24377": ["TP53 Regulates Metabolic Genes", "Pentose phosphate pathway"], "24379": ["GABA synthesis", "GABA synthesis, release, reuptake and degradation"], "24380": ["GABA synthesis", "GABA synthesis, release, reuptake and degradation"], "24384": ["Vitamin D (calciferol) metabolism"], "24385": ["Regulation of Glucokinase by Glucokinase Regulatory Protein", "Glycolysis"], "24390": ["Lactose synthesis", "Neutrophil degranulation", "N-Glycan antennae elongation"], "24391": ["Prolactin receptor signaling", "Synthesis, secretion, and deacylation of Ghrelin", "Growth hormone receptor signaling"], "24392": ["Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "Gap junction assembly", "Gap junction degradation", "c-src mediated regulation of Cx43 function and closure of gap junctions", "Formation of annular gap junctions", "Transport of connexins along the secretory pathway"], "24397": ["Neurotransmitter receptors and postsynaptic signal transmission"], "24399": ["Transcriptional activation of mitochondrial biogenesis", "Amino acid synthesis and interconversion (transamination)"], "24400": ["Activation of G protein gated Potassium channels", "G-protein activation", "Activation of the phototransduction cascade", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Olfactory Signaling Pathway", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42", "Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "24401": ["Amino acid synthesis and interconversion (transamination)"], "24406": ["Activation of Ca-permeable Kainate Receptor"], "24407": ["Activation of Ca-permeable Kainate Receptor"], "24408": ["EPHB-mediated forward signaling", "Unblocking of NMDA receptors, glutamate binding and activation", "RAF/MAP kinase cascade", "Synaptic adhesion-like molecules"], "24410": ["EPHB-mediated forward signaling", "Unblocking of NMDA receptors, glutamate binding and activation", "RAF/MAP kinase cascade", "Synaptic adhesion-like molecules"], "24411": ["Unblocking of NMDA receptors, glutamate binding and activation", "Synaptic adhesion-like molecules"], "24412": ["Unblocking of NMDA receptors, glutamate binding and activation", "RAF/MAP kinase cascade", "Synaptic adhesion-like molecules"], "24414": ["G alpha (q) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)", "Neurexins and neuroligins"], "24415": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "24416": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "24419": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "24420": ["Eukaryotic Translation Termination", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "24424": ["Glutathione conjugation"], "24426": ["Glutathione conjugation", "Detoxification of Reactive Oxygen Species", "Neutrophil degranulation"], "24439": ["Pyruvate metabolism"], "24446": ["Platelet degranulation ", "PIP3 activates AKT signaling", "RAF/MAP kinase cascade", "MET Receptor Activation", "Negative regulation of MET activity", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "MET activates RAS signaling", "MET activates PI3K/AKT signaling", "MET activates PTPN11", "MET activates PTK2 signaling", "MET interacts with TNS proteins", "MET activates RAP1 and RAC1", "MET receptor recycling", "MET activates STAT3"], "24450": ["Synthesis of Ketone Bodies"], "24451": ["Heme degradation", "Iron uptake and transport"], "24465": ["Purine salvage"], "24471": ["VEGFA-VEGFR2 Pathway", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "MAPK6/MAPK4 signaling"], "24472": ["Regulation of HSF1-mediated heat shock response", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Attenuation phase", "HSF1-dependent transactivation", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Neutrophil degranulation"], "24476": ["G alpha (s) signalling events", "Calcitonin-like ligand receptors"], "24477": ["Integrin cell surface interactions"], "24479": ["NADPH regeneration", "Neutrophil degranulation", "Peroxisomal protein import"], "24481": ["Interferon alpha/beta signaling", "Regulation of IFNA signaling"], "24482": ["Platelet degranulation ", "Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "IRS-related events triggered by IGF1R", "SHC-related events triggered by IGF1R", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Synthesis, secretion, and deacylation of Ghrelin"], "24483": ["Platelet degranulation ", "Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "IRS-related events triggered by IGF1R", "SHC-related events triggered by IGF1R", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "24494": ["Interleukin-1 processing", "CLEC7A/inflammasome pathway", "Interleukin-1 signaling"], "24498": ["Interleukin-6 signaling", "MAPK3 (ERK1) activation", "MAPK1 (ERK2) activation", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "24504": ["Glycoprotein hormones"], "24505": ["Insulin processing", "Synthesis, secretion, and deacylation of Ghrelin", "COPI-mediated anterograde transport", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "IRS activation", "Signal attenuation", "Insulin receptor signalling cascade", "Signaling by Insulin receptor", "Insulin receptor recycling"], "24506": ["Insulin processing", "Synthesis, secretion, and deacylation of Ghrelin", "COPI-mediated anterograde transport", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "IRS activation", "Signal attenuation", "Insulin receptor signalling cascade", "Signaling by Insulin receptor", "Insulin receptor recycling"], "24511": ["Elastic fibre formation", "Fibronectin matrix formation", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "Basigin interactions", "Molecules associated with elastic fibres", "Integrin cell surface interactions", "Laminin interactions", "Syndecan interactions", "ECM proteoglycans", "Signal transduction by L1", "Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "MET activates PTK2 signaling", "MET interacts with TNS proteins"], "24513": ["Branched-chain amino acid catabolism"], "24514": ["Interleukin-6 signaling", "MAPK3 (ERK1) activation", "MAPK1 (ERK2) activation", "Prolactin receptor signaling", "Signaling by SCF-KIT", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "RAF activation", "RAF/MAP kinase cascade", "Interleukin-4 and Interleukin-13 signaling", "IL-6-type cytokine receptor ligand interactions", "Cyclin D associated events in G1", "Interferon gamma signaling", "Regulation of IFNG signaling", "Interleukin-20 family signaling", "Interleukin-35 Signalling", "Interleukin-12 signaling", "Interleukin-23 signaling", "Interleukin-27 signaling", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "Erythropoietin activates RAS", "Interleukin receptor SHC signaling", "Growth hormone receptor signaling", "Factors involved in megakaryocyte development and platelet production"], "24516": ["Oxidative Stress Induced Senescence", "FCERI mediated MAPK activation", "Activation of the AP-1 family of transcription factors", "Estrogen-dependent gene expression"], "24520": ["Voltage gated Potassium channels"], "24521": ["Potassium transport channels"], "24522": ["Generic Transcription Pathway"], "24525": ["Activation of RAS in B cells", "SHC1 events in ERBB4 signaling", "Signaling by SCF-KIT", "p38MAPK events", "GRB2 events in EGFR signaling", "SHC1 events in EGFR signaling", "Downstream signal transduction", "GRB2 events in ERBB2 signaling", "Tie2 Signaling", "EGFR Transactivation by Gastrin", "DAP12 signaling", "FCERI mediated MAPK activation", "NCAM signaling for neurite out-growth", "VEGFR2 mediated cell proliferation", "CD209 (DC-SIGN) signaling", "SHC-mediated cascade:FGFR1", "FRS-mediated FGFR1 signaling", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "Regulation of RAS by GAPs", "RAF activation", "RAF/MAP kinase cascade", "MAP2K and MAPK activation", "Negative regulation of MAPK pathway", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "MET activates RAS signaling", "RUNX3 regulates p14-ARF"], "24528": ["Lactose synthesis"], "24530": ["HDL remodeling"], "24533": ["Pyruvate metabolism"], "24534": ["Pyruvate metabolism"], "24538": ["Assembly of active LPL and LIPC lipase complexes", "Chylomicron clearance"], "24539": ["Assembly of active LPL and LIPC lipase complexes", "Chylomicron remodeling"], "24546": ["Transport of organic anions"], "24551": ["Gluconeogenesis"], "24560": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "24561": ["Cleavage of the damaged purine", "Displacement of DNA glycosylase by APEX1"], "245709": ["Insulin processing", "VxPx cargo-targeting to cilium"], "24571": ["O-linked glycosylation of mucins", "Termination of O-glycan biosynthesis"], "24575": ["ISG15 antiviral mechanism"], "24582": ["Smooth Muscle Contraction", "RHO GTPases activate PAKs"], "24584": ["Smooth Muscle Contraction"], "24585": ["Striated Muscle Contraction"], "24590": ["Metabolism of Angiotensinogen to Angiotensins", "Neutrophil degranulation"], "24591": ["Glycosphingolipid metabolism", "Sialic acid metabolism", "Neutrophil degranulation"], "245920": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "245922": ["Transport of Mature mRNA derived from an Intron-Containing Transcript", "SUMOylation of DNA damage response and repair proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of DNA replication proteins"], "245955": ["Platelet degranulation "], "245956": ["Phase 0 - rapid depolarisation"], "245957": ["mRNA Splicing - Major Pathway"], "245958": ["Formation of ATP by chemiosmotic coupling", "Cristae formation"], "24596": ["Axonal growth inhibition (RHOA activation)", "Regulated proteolysis of p75NTR", "NFG and proNGF binds to p75NTR", "NADE modulates death signalling", "NRIF signals cell death from the nucleus", "p75NTR recruits signalling complexes", "NF-kB is activated and signals survival", "Axonal growth stimulation"], "245961": ["Choline catabolism"], "245962": ["Cell surface interactions at the vascular wall"], "245974": ["Neddylation"], "245976": ["Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "mRNA Splicing - Major Pathway"], "245977": ["Surfactant metabolism"], "245979": ["RUNX1 regulates transcription of genes involved in differentiation of HSCs"], "24598": ["ROS, RNS production in phagocytes", "Nitric oxide stimulates guanylate cyclase", "Ion homeostasis"], "245981": ["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "245983": ["IL-6-type cytokine receptor ligand interactions"], "245986": ["Activation of G protein gated Potassium channels", "G-protein activation", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42", "Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "24602": ["Physiological factors"], "24603": ["Physiological factors"], "24604": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "246046": ["Cobalamin (Cbl, vitamin B12) transport and metabolism"], "24605": ["Activation of RAS in B cells", "SHC1 events in ERBB4 signaling", "Signaling by SCF-KIT", "p38MAPK events", "GRB2 events in EGFR signaling", "SHC1 events in EGFR signaling", "Downstream signal transduction", "GRB2 events in ERBB2 signaling", "Tie2 Signaling", "EGFR Transactivation by Gastrin", "DAP12 signaling", "FCERI mediated MAPK activation", "NCAM signaling for neurite out-growth", "VEGFR2 mediated cell proliferation", "CD209 (DC-SIGN) signaling", "SHC-mediated cascade:FGFR1", "FRS-mediated FGFR1 signaling", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "Regulation of RAS by GAPs", "RAF activation", "RAF/MAP kinase cascade", "MAP2K and MAPK activation", "Negative regulation of MAPK pathway", "Neutrophil degranulation", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "MET activates RAS signaling"], "246060": ["Cyclin D associated events in G1"], "246074": ["Fatty acyl-CoA biosynthesis"], "24609": ["Regulation of ornithine decarboxylase (ODC)", "Metabolism of polyamines"], "246097": ["Regulation by c-FLIP", "RIPK1-mediated regulated necrosis", "CASP8 activity is inhibited", "Dimerization of procaspase-8", "FasL/ CD95L signaling"], "246115": ["Sphingolipid de novo biosynthesis"], "246116": ["Toll Like Receptor 4 (TLR4) Cascade"], "246117": ["COPII-mediated vesicle transport", "Cargo concentration in the ER"], "246118": ["Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Recruitment of NuMA to mitotic centrosomes", "Recycling pathway of L1", "Hedgehog 'off' state", "Cilium Assembly", "Intraflagellar transport", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "Carboxyterminal post-translational modifications of tubulin", "Kinesins"], "24613": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "246142": ["BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "Activation of BMF and translocation to mitochondria"], "246144": ["Interleukin-3, Interleukin-5 and GM-CSF signaling", "RAF/MAP kinase cascade", "Interleukin receptor SHC signaling"], "246145": ["MAP2K and MAPK activation", "Negative regulation of MAPK pathway"], "246147": ["Collagen degradation", "Degradation of the extracellular matrix", "Trafficking and processing of endosomal TLR", "Assembly of collagen fibrils and other multimeric structures", "MHC class II antigen presentation", "RUNX1 regulates transcription of genes involved in differentiation of keratinocytes"], "246150": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Phase 3 - rapid repolarisation", "Phase 2 - plateau phase", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "246153": ["Voltage gated Potassium channels", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion"], "24616": ["Phenylalanine and tyrosine catabolism"], "24618": ["Antimicrobial peptides"], "24620": ["Antimicrobial peptides"], "246209": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "246216": ["Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "mRNA Splicing - Major Pathway"], "246217": ["NRAGE signals death through JNK", "Rho GTPase cycle", "EPHA-mediated growth cone collapse"], "246219": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "246234": ["Type II Na+/Pi cotransporters"], "246237": ["Synthesis of PIPs at the plasma membrane"], "246238": ["Antimicrobial peptides"], "246239": ["Proton/oligopeptide cotransporters"], "24624": ["Biotin transport and metabolism", "Propionyl-CoA catabolism"], "246240": ["TRP channels", "RIPK1-mediated regulated necrosis"], "246244": ["Regulation of TNFR1 signaling", "Negative regulators of DDX58/IFIH1 signaling"], "246245": ["FMO oxidises nucleophiles"], "246249": ["Rho GTPase cycle"], "246250": ["Neutrophil degranulation"], "246253": ["AMPK inhibits chREBP transcriptional activation activity"], "246254": ["G alpha (i) signalling events"], "24626": ["DARPP-32 events", "G alpha (s) signalling events"], "246264": ["Generic Transcription Pathway"], "24627": ["DARPP-32 events", "G alpha (s) signalling events"], "246272": ["Neutrophil degranulation"], "246273": ["PIP3 activates AKT signaling", "Activation of AKT2", "Negative regulation of the PI3K/AKT network", "CD28 dependent PI3K/Akt signaling", "VEGFR2 mediated vascular permeability"], "246279": ["Generic Transcription Pathway"], "24628": ["Platelet degranulation ", "PIP3 activates AKT signaling", "Downstream signal transduction", "Signaling by PDGF", "Non-integrin membrane-ECM interactions", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "246281": ["Serotonin and melatonin biosynthesis"], "24629": ["PIP3 activates AKT signaling", "Downstream signal transduction", "Signaling by PDGF", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "246294": ["Regulation of PLK1 Activity at G2/M Transition", "TBC/RABGAPs"], "246307": ["Phenylalanine and tyrosine catabolism"], "246310": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "Clathrin-mediated endocytosis"], "246311": ["Regulation of pyruvate dehydrogenase (PDH) complex"], "246324": ["Neutrophil degranulation", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "246328": ["Platelet degranulation "], "246331": ["Neurophilin interactions with VEGF and VEGFR", "Sema3A PAK dependent Axon repulsion", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "CRMPs in Sema3A signaling", "Signal transduction by L1"], "246334": ["Regulation of TP53 Activity through Association with Co-factors"], "246358": ["Platelet degranulation ", "Chemokine receptors bind chemokines", "G alpha (i) signalling events", "Neutrophil degranulation"], "24638": ["Glycolysis"], "24640": ["Glycolysis"], "24642": ["Neutrophil degranulation", "Gluconeogenesis"], "24644": ["Gluconeogenesis"], "24645": ["Glycogen synthesis", "Neutrophil degranulation"], "24648": ["Platelet degranulation ", "COPII-mediated vesicle transport", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Cargo concentration in the ER", "Neutrophil degranulation", "Post-translational protein phosphorylation"], "24650": ["VxPx cargo-targeting to cilium"], "24651": ["Glycolysis"], "24653": ["phospho-PLA2 pathway", "Acyl chain remodelling of PC", "Acyl chain remodeling of CL", "Acyl chain remodelling of PS", "Acyl chain remodelling of PE", "Acyl chain remodelling of PI", "Hydrolysis of LPC", "Synthesis of PA", "Arachidonic acid metabolism", "ADP signalling through P2Y purinoceptor 1", "Platelet sensitization by LDL", "COPI-independent Golgi-to-ER retrograde traffic"], "24664": ["Opioid Signalling", "Androgen biosynthesis", "Glucocorticoid biosynthesis", "G-protein activation", "Peptide hormone biosynthesis", "Endogenous sterols", "Peptide ligand-binding receptors", "G alpha (s) signalling events", "G alpha (i) signalling events"], "24667": ["ISG15 antiviral mechanism"], "24668": ["DARPP-32 events"], "24669": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "24672": ["Inhibition of replication initiation of damaged DNA by RB1/E2F1", "Spry regulation of FGF signaling", "Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "DARPP-32 events", "Degradation of beta-catenin by the destruction complex", "Beta-catenin phosphorylation cascade", "ERK/MAPK targets", "ERKs are inactivated", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "CTLA4 inhibitory signaling", "RHO GTPases Activate Formins", "RAF activation", "Regulation of TP53 Degradation", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Mitotic Prometaphase", "Cyclin D associated events in G1", "Cyclin A/B1/B2 associated events during G2/M transition", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "24673": ["Inhibition of replication initiation of damaged DNA by RB1/E2F1", "Spry regulation of FGF signaling", "Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "DARPP-32 events", "Degradation of beta-catenin by the destruction complex", "Beta-catenin phosphorylation cascade", "ERK/MAPK targets", "ERKs are inactivated", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "CTLA4 inhibitory signaling", "RHO GTPases Activate Formins", "RAF activation", "Regulation of TP53 Degradation", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Mitotic Prometaphase", "Cyclin D associated events in G1", "Cyclin A/B1/B2 associated events during G2/M transition"], "24674": ["Calcineurin activates NFAT", "FCERI mediated Ca+2 mobilization", "Ca2+ pathway", "CLEC7A (Dectin-1) induces NFAT activation"], "246756": ["Regulation by c-FLIP", "RIPK1-mediated regulated necrosis", "CASP8 activity is inhibited", "TNFR1-induced proapoptotic signaling", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "Dimerization of procaspase-8", "TNF signaling"], "246759": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "246760": ["Factors involved in megakaryocyte development and platelet production"], "246768": ["Deactivation of the beta-catenin transactivating complex"], "24677": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "246775": ["Regulation by c-FLIP", "RIPK1-mediated regulated necrosis", "CASP8 activity is inhibited", "Dimerization of procaspase-8", "TRAIL  signaling"], "24679": ["PKA activation", "PKA activation in glucagon signalling", "DARPP-32 events", "Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Vasopressin regulates renal water homeostasis via Aquaporins", "CREB1 phosphorylation through the activation of Adenylate Cyclase", "Hedgehog 'off' state", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2", "Factors involved in megakaryocyte development and platelet production"], "24680": ["Calmodulin induced events", "Disinhibition of SNARE formation", "SHC1 events in ERBB2 signaling", "Signaling by SCF-KIT", "Regulation of KIT signaling", "EGFR Transactivation by Gastrin", "Syndecan interactions", "Acetylcholine regulates insulin secretion", "Depolymerisation of the Nuclear Lamina", "HuR (ELAVL1) binds and stabilizes mRNA", "WNT5A-dependent internalization of FZD4", "VEGFR2 mediated cell proliferation", "Response to elevated platelet cytosolic Ca2+", "RET signaling", "ROBO receptors bind AKAP5"], "24681": ["Calmodulin induced events", "Disinhibition of SNARE formation", "WNT5A-dependent internalization of FZD4", "Response to elevated platelet cytosolic Ca2+"], "24683": ["Prolactin receptor signaling", "Growth hormone receptor signaling"], "24689": ["5-Phosphoribose 1-diphosphate biosynthesis"], "24691": ["Collagen degradation", "Activation of Matrix Metalloproteinases", "Cobalamin (Cbl, vitamin B12) transport and metabolism", "Neutrophil degranulation", "Antimicrobial peptides"], "24693": ["COX reactions", "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"], "24694": ["Class B/2 (Secretin family receptors)", "G alpha (s) signalling events"], "24697": ["Integrin alphaIIb beta3 signaling", "Negative regulation of MET activity", "PTK6 Down-Regulation", "Growth hormone receptor signaling"], "24699": ["Phosphorylation of CD3 and TCR zeta chains", "Other semaphorin interactions", "Neutrophil degranulation"], "24701": ["Glycogen breakdown (glycogenolysis)"], "24703": ["Stimuli-sensing channels", "Rap1 signalling", "GP1b-IX-V activation signalling", "CD209 (DC-SIGN) signaling", "RAF activation", "MAP2K and MAPK activation", "Negative feedback regulation of MAPK pathway", "Negative regulation of MAPK pathway"], "24705": ["Nuclear Receptor transcription pathway", "Signaling by Retinoic Acid"], "24706": ["Nuclear Receptor transcription pathway", "Signaling by Retinoic Acid"], "24710": ["Retinoid metabolism and transport"], "24711": ["The canonical retinoid cycle in rods (twilight vision)"], "24715": ["Metabolism of Angiotensinogen to Angiotensins"], "24716": ["RAF/MAP kinase cascade", "RET signaling"], "24717": ["The canonical retinoid cycle in rods (twilight vision)", "Activation of the phototransduction cascade", "Inactivation, recovery and regulation of the phototransduction cascade", "G alpha (i) signalling events", "Opsins", "VxPx cargo-targeting to cilium"], "24747": ["ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "24765": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "24767": ["Stimuli-sensing channels"], "24769": ["G alpha (s) signalling events", "Glucagon-type ligand receptors"], "24771": ["A tetrasaccharide linker sequence is required for GAG synthesis", "HS-GAG biosynthesis", "HS-GAG degradation", "Cell surface interactions at the vascular wall", "Syndecan interactions", "Retinoid metabolism and transport"], "24772": ["Signaling by ROBO receptors", "Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "24773": ["Signal regulatory protein family interactions", "Surfactant metabolism", "Regulation of TLR by endogenous ligand"], "24777": ["Recycling of bile acids and salts"], "24778": ["Cellular hexose transport", "Vitamin C (ascorbate) metabolism", "Regulation of insulin secretion", "Lactose synthesis"], "24779": ["Erythrocytes take up carbon dioxide and release oxygen", "Bicarbonate transporters"], "24780": ["Bicarbonate transporters"], "24781": ["Bicarbonate transporters"], "24782": ["Hyaluronan uptake and degradation", "Sodium/Proton exchangers"], "24783": ["Sodium/Proton exchangers"], "24784": ["Sodium/Proton exchangers"], "24786": ["Platelet degranulation ", "Detoxification of Reactive Oxygen Species"], "24787": ["Transcriptional activation of mitochondrial biogenesis", "Detoxification of Reactive Oxygen Species"], "24788": ["Fructose biosynthesis", "Formation of xylulose-5-phosphate"], "24790": ["SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "RNA polymerase II transcribes snRNA genes", "Estrogen-dependent gene expression"], "24791": ["Platelet degranulation ", "ECM proteoglycans", "Scavenging by Class H Receptors"], "24792": ["Glyoxylate metabolism and glycine degradation", "Peroxisomal protein import"], "24794": ["Platelet degranulation ", "Neutrophil degranulation"], "24796": ["Cell surface interactions at the vascular wall", "Basigin interactions"], "24797": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "24800": ["Glycosphingolipid metabolism", "The activation of arylsulfatases"], "24803": ["Serotonin Neurotransmitter Release Cycle", "Norepinephrine Neurotransmitter Release Cycle", "Glutamate Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle", "Acetylcholine Neurotransmitter Release Cycle", "Clathrin derived vesicle budding", "Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis", "Other interleukin signaling", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "GABA synthesis, release, reuptake and degradation"], "24806": ["Tachykinin receptors bind tachykinins", "G alpha (q) signalling events"], "24807": ["Tachykinin receptors bind tachykinins", "G alpha (q) signalling events", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "24808": ["Tachykinin receptors bind tachykinins", "G alpha (q) signalling events"], "24811": ["ER-Phagosome pathway", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "24812": ["ER-Phagosome pathway", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "24813": ["Phenylalanine and tyrosine catabolism"], "24816": ["Prostanoid ligand receptors", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "Thromboxane signalling through TP receptor"], "24818": ["Association of TriC/CCT with target proteins during biosynthesis", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "24825": ["Platelet degranulation ", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "Post-translational protein phosphorylation", "Iron uptake and transport", "Transferrin endocytosis and recycling"], "24827": ["PIP3 activates AKT signaling", "Signaling by EGFR", "GRB2 events in EGFR signaling", "GAB1 signalosome", "SHC1 events in EGFR signaling", "EGFR downregulation", "COPII-mediated vesicle transport", "EGFR interacts with phospholipase C-gamma", "RAF/MAP kinase cascade", "Cargo concentration in the ER", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "24828": ["Metalloprotease DUBs"], "24829": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HATs acetylate histones", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "E3 ubiquitin ligases ubiquitinate target proteins", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "24831": ["Nuclear Receptor transcription pathway", "SUMOylation of intracellular receptors"], "24832": ["Post-translational modification: synthesis of GPI-anchored proteins"], "24834": ["Pyrimidine salvage"], "24835": ["TNFR1-induced proapoptotic signaling", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "TNFR1-mediated ceramide production", "TNFR2 non-canonical NF-kB pathway", "TNF signaling"], "24837": ["Striated Muscle Contraction"], "24838": ["Striated Muscle Contraction"], "24841": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "24848": ["Serotonin and melatonin biosynthesis"], "24849": ["Glycolysis"], "24852": ["Striated Muscle Contraction", "Smooth Muscle Contraction"], "24854": ["Platelet degranulation ", "Terminal pathway of complement", "Antimicrobial peptides", "Regulation of Complement cascade"], "24855": ["Macroautophagy", "Inhibition of TSC complex formation by PKB", "AKT phosphorylates targets in the cytosol", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "TBC/RABGAPs"], "24856": ["The canonical retinoid cycle in rods (twilight vision)", "Non-integrin membrane-ECM interactions", "Neutrophil degranulation", "Retinoid metabolism and transport"], "24860": ["The fatty acid cycling model", "The proton buffering model"], "24861": ["Glucuronidation", "Heme degradation"], "24862": ["Glucuronidation"], "24874": ["Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "SUMOylation of ubiquitinylation proteins", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "24881": ["TCF dependent signaling in response to WNT", "WNT ligand biogenesis and trafficking", "PCP/CE pathway", "Disassembly of the destruction complex and recruitment of AXIN to the membrane"], "24882": ["TCF dependent signaling in response to WNT", "WNT ligand biogenesis and trafficking"], "24886": ["Eicosanoids", "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"], "24887": ["Release of apoptotic factors from the mitochondria", "Activation, translocation and oligomerization of BAX", "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest"], "24889": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "24890": ["Nuclear signaling by ERBB4", "PIP3 activates AKT signaling", "Nuclear Receptor transcription pathway", "SUMOylation of intracellular receptors", "Ovarian tumor domain proteases", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "RUNX1 regulates estrogen receptor mediated transcription", "ESR-mediated signaling", "Estrogen-dependent gene expression"], "24898": ["Dopamine clearance from the synaptic cleft", "Na+/Cl- dependent neurotransmitter transporters"], "24904": ["Norepinephrine Neurotransmitter Release Cycle", "Abacavir transmembrane transport", "Na+/Cl- dependent neurotransmitter transporters", "Organic cation transport"], "24907": ["Striated Muscle Contraction"], "24913": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PS", "Acyl chain remodelling of PE", "Acyl chain remodelling of PI"], "24914": ["Crosslinking of collagen fibrils"], "24919": ["UCH proteinases", "DNA Damage Recognition in GG-NER", "Estrogen-dependent gene expression"], "24923": ["LGI-ADAM interactions"], "24929": ["Prostanoid ligand receptors", "G alpha (i) signalling events"], "24930": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "24932": ["Alpha-defensins", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "PD-1 signaling", "Other interleukin signaling", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "24934": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "DAP12 signaling"], "24936": ["Platelet degranulation ", "Sperm:Oocyte Membrane Binding"], "24938": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "24941": ["Ion influx/efflux at host-pathogen interface", "Ion transport by P-type ATPases"], "24944": ["Platelet degranulation ", "Neutrophil degranulation"], "24946": ["Extrinsic Pathway of Fibrin Clot Formation", "Intrinsic Pathway of Fibrin Clot Formation", "Gamma-carboxylation of protein precursors", "Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "Removal of aminoterminal propeptides from gamma-carboxylated proteins"], "24947": ["GABA A receptor activation"], "24949": ["Serotonin Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle"], "24950": ["Androgen biosynthesis"], "24952": ["Glucagon signaling in metabolic regulation", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "G alpha (q) signalling events", "G alpha (s) signalling events", "Glucagon-type ligand receptors", "Synthesis, secretion, and deacylation of Ghrelin"], "24953": ["Glucagon signaling in metabolic regulation", "G alpha (q) signalling events", "G alpha (s) signalling events", "Glucagon-type ligand receptors"], "24954": ["PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "IRS activation", "Signal attenuation", "Insulin receptor signalling cascade", "Signaling by Insulin receptor", "Insulin receptor recycling"], "24957": ["Astrocytic Glutamate-Glutamine Uptake And Metabolism", "Amino acid synthesis and interconversion (transamination)"], "24959": ["Gluconeogenesis"], "24963": ["Regulation of HSF1-mediated heat shock response", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Attenuation phase", "HSF1-dependent transactivation"], "24967": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "24968": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "24973": ["ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "24974": ["ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "24981": ["Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "MHC class II antigen presentation", "PD-1 signaling"], "24984": ["MHC class II antigen presentation"], "24988": ["ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "25007": ["Tachykinin receptors bind tachykinins", "G alpha (q) signalling events"], "25008": ["TNFR2 non-canonical NF-kB pathway", "TNFs bind their physiological receptors", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "25014": ["Branched-chain amino acid catabolism"], "25019": ["Nonhomologous End-Joining (NHEJ)", "Neutrophil degranulation"], "25022": ["PI3K Cascade", "PIP3 activates AKT signaling", "FGFR2c ligand binding and activation", "FGFR2b ligand binding and activation", "Phospholipase C-mediated cascade; FGFR2", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "Negative regulation of FGFR2 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "25024": ["G alpha (s) signalling events", "Glucagon-type ligand receptors"], "25026": ["G alpha (s) signalling events", "Calcitonin-like ligand receptors"], "25027": ["Basigin interactions", "Proton-coupled monocarboxylate transport", "Pyruvate metabolism"], "25028": ["Purine salvage"], "25029": ["G alpha (s) signalling events", "Calcitonin-like ligand receptors"], "25031": ["PLC beta mediated events", "Synthesis of IP3 and IP4 in the cytosol", "G alpha (q) signalling events"], "25033": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "25035": ["Vitamin C (ascorbate) metabolism", "Phase I - Functionalization of compounds", "Neutrophil degranulation"], "25040": ["Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)", "G alpha (s) signalling events", "Glucagon-type ligand receptors"], "25041": ["Elevation of cytosolic Ca2+ levels", "Platelet homeostasis"], "25043": ["Degradation of the extracellular matrix", "Elastic fibre formation", "Molecules associated with elastic fibres"], "25044": ["Threonine catabolism"], "25045": ["Mitochondrial Fatty Acid Beta-Oxidation"], "25048": ["Intrinsic Pathway of Fibrin Clot Formation", "Activation of Matrix Metalloproteinases"], "25050": ["CaMK IV-mediated phosphorylation of CREB", "CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde"], "25052": ["Collagen degradation", "Activation of Matrix Metalloproteinases", "Cobalamin (Cbl, vitamin B12) transport and metabolism", "Neutrophil degranulation", "Antimicrobial peptides"], "25053": ["Fatty acids", "Miscellaneous substrates", "Xenobiotics", "CYP2E1 reactions", "Biosynthesis of maresin-like SPMs"], "25054": ["Activated NTRK2 signals through PLCG1", "Activated NTRK2 signals through FRS2 and FRS3", "NTRK2 activates RAC1"], "25055": ["LDL clearance"], "25056": ["The canonical retinoid cycle in rods (twilight vision)", "Retinoid metabolism and transport"], "25059": ["Glycolysis"], "25060": ["Neutrophil degranulation", "Glycolysis"], "25061": ["RA biosynthesis pathway"], "25065": ["Cation-coupled Chloride cotransporters"], "25066": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Nectin/Necl  trans heterodimerization"], "25073": ["Scavenging by Class B Receptors", "HDL clearance"], "25075": ["Serotonin receptors", "G alpha (i) signalling events"], "25081": ["Platelet degranulation ", "ABC transporters in lipid homeostasis", "Scavenging of heme from plasma", "Scavenging by Class B Receptors", "Scavenging by Class A Receptors", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation", "Chylomicron assembly", "HDL assembly", "Chylomicron remodeling", "HDL clearance", "HDL remodeling", "Retinoid metabolism and transport"], "25083": ["Adrenoceptors", "Adrenaline signalling through Alpha-2 adrenergic receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "G alpha (i) signalling events", "G alpha (z) signalling events", "Surfactant metabolism"], "25084": ["Interleukin-4 and Interleukin-13 signaling"], "25085": ["Catecholamine biosynthesis"], "25086": ["Xenobiotics", "CYP2E1 reactions", "Biosynthesis of maresin-like SPMs"], "25094": ["SUMOylation of transcription factors"], "25096": ["Synthesis of PA", "Role of phospholipids in phagocytosis", "Neutrophil degranulation"], "25101": ["Highly sodium permeable acetylcholine nicotinic receptors", "Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "Highly calcium permeable nicotinic acetylcholine receptors"], "25103": ["Highly sodium permeable acetylcholine nicotinic receptors", "Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "Highly calcium permeable nicotinic acetylcholine receptors", "Neutrophil degranulation"], "25104": ["Biotin transport and metabolism", "Gluconeogenesis"], "25107": ["Vasopressin-like receptors", "G alpha (q) signalling events"], "25108": ["Vasopressin-like receptors", "G alpha (s) signalling events", "Vasopressin regulates renal water homeostasis via Aquaporins", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "25110": ["DAP12 interactions", "DAP12 signaling"], "25111": ["Muscarinic acetylcholine receptors", "G alpha (i) signalling events"], "25112": ["TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest"], "25114": ["PI3K Cascade", "PIP3 activates AKT signaling", "betaKlotho-mediated ligand binding", "FGFR4 ligand binding and activation", "Phospholipase C-mediated cascade; FGFR4", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "PI-3K cascade:FGFR4", "Negative regulation of FGFR4 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "25117": ["Glucocorticoid biosynthesis"], "25118": ["Integrin cell surface interactions", "Smooth Muscle Contraction"], "25120": ["Serotonin and melatonin biosynthesis"], "25122": ["Stimuli-sensing channels"], "25124": ["Interleukin-6 signaling", "ISG15 antiviral mechanism", "Signaling by SCF-KIT", "Downstream signal transduction", "Interleukin-4 and Interleukin-13 signaling", "Interferon gamma signaling", "Regulation of IFNG signaling", "Interleukin-20 family signaling", "Interleukin-35 Signalling", "Interleukin-9 signaling", "Interleukin-27 signaling", "Interleukin-21 signaling", "Interferon alpha/beta signaling", "Regulation of IFNA signaling"], "25125": ["Interleukin-6 signaling", "Interleukin-7 signaling", "Signaling by SCF-KIT", "Downstream signal transduction", "Interleukin-10 signaling", "Interleukin-4 and Interleukin-13 signaling", "PTK6 Activates STAT3", "Interleukin-20 family signaling", "MET activates STAT3", "Interleukin-15 signaling", "Interleukin-35 Signalling", "Interleukin-9 signaling", "Interleukin-37 signaling", "Interleukin-23 signaling", "Interleukin-27 signaling", "Interleukin-21 signaling"], "25126": ["Interleukin-7 signaling", "Signaling by SCF-KIT", "Downstream signal transduction", "Signaling by Leptin", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "Interleukin-20 family signaling", "Interleukin-15 signaling", "Interleukin-9 signaling", "Interleukin-2 signaling", "Interleukin-21 signaling", "Growth hormone receptor signaling"], "25132": ["Vasopressin regulates renal water homeostasis via Aquaporins"], "25134": ["Glyoxylate metabolism and glycine degradation"], "25135": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "25136": ["RAF/MAP kinase cascade", "RET signaling"], "25139": ["Cellular hexose transport"], "25146": ["Androgen biosynthesis", "Glucocorticoid biosynthesis"], "25149": ["PIP3 activates AKT signaling", "Nuclear Receptor transcription pathway", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "ESR-mediated signaling"], "25150": ["GPVI-mediated activation cascade", "Signaling by ERBB2", "PIP3 activates AKT signaling", "Signaling by SCF-KIT", "Regulation of KIT signaling", "Cell surface interactions at the vascular wall", "FCGR activation", "DAP12 signaling", "Nephrin family interactions", "NCAM signaling for neurite out-growth", "CD28 co-stimulation", "CD28 dependent PI3K/Akt signaling", "CD28 dependent Vav1 pathway", "CTLA4 inhibitory signaling", "EPHB-mediated forward signaling", "EPHA-mediated growth cone collapse", "Ephrin signaling", "EPH-ephrin mediated repulsion of cells", "Sema3A PAK dependent Axon repulsion", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "CRMPs in Sema3A signaling", "DCC mediated attractive signaling", "VEGFA-VEGFR2 Pathway", "CD209 (DC-SIGN) signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Platelet Adhesion to exposed collagen", "NTRK2 activates RAC1", "Regulation of signaling by CBL"], "25151": ["Golgi Associated Vesicle Biogenesis", "Neutrophil degranulation", "Retrograde transport at the Trans-Golgi-Network", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "25159": ["RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Factors involved in megakaryocyte development and platelet production"], "25164": ["Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "Oncogene Induced Senescence", "Cyclin D associated events in G1"], "25167": ["NCAM signaling for neurite out-growth", "RAF/MAP kinase cascade"], "25172": ["RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Factors involved in megakaryocyte development and platelet production"], "25176": ["Regulation of insulin secretion"], "25179": ["Citric acid cycle (TCA cycle)"], "25181": ["A tetrasaccharide linker sequence is required for GAG synthesis", "Chondroitin sulfate biosynthesis", "Dermatan sulfate biosynthesis", "CS/DS degradation", "ECM proteoglycans"], "25183": ["Rho GTPase cycle", "RAB GEFs exchange GTP for GDP on RABs"], "25186": ["EPH-Ephrin signaling", "EPHB-mediated forward signaling", "Ephrin signaling", "EPH-ephrin mediated repulsion of cells"], "25194": ["Hormone ligand-binding receptors", "G alpha (q) signalling events"], "25197": ["Sialic acid metabolism", "N-Glycan antennae elongation", "Termination of O-glycan biosynthesis"], "25203": ["APC/C:Cdc20 mediated degradation of Cyclin B", "Phosphorylation of Emi1", "Resolution of Sister Chromatid Cohesion", "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "Cyclin A/B1/B2 associated events during G2/M transition", "G2/M DNA replication checkpoint", "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "The role of GTSE1 in G2/M progression after G2 checkpoint"], "25204": ["Peptide hormone biosynthesis"], "25216": ["A tetrasaccharide linker sequence is required for GAG synthesis", "HS-GAG biosynthesis", "HS-GAG degradation", "Cell surface interactions at the vascular wall", "Syndecan interactions", "Other interleukin signaling", "Retinoid metabolism and transport"], "25217": ["ER-Phagosome pathway", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "25218": ["Retrograde transport at the Trans-Golgi-Network"], "25221": ["Deactivation of the beta-catenin transactivating complex"], "25227": ["Glycosphingolipid metabolism", "The activation of arylsulfatases", "CS/DS degradation", "Neutrophil degranulation"], "25229": ["Muscarinic acetylcholine receptors", "G alpha (q) signalling events"], "25230": ["Miscellaneous transport and binding events"], "25233": ["PIP3 activates AKT signaling", "Activation of AKT2", "Inhibition of TSC complex formation by PKB", "AKT phosphorylates targets in the cytosol", "AKT phosphorylates targets in the nucleus", "Negative regulation of the PI3K/AKT network", "Deactivation of the beta-catenin transactivating complex", "CD28 dependent PI3K/Akt signaling", "CTLA4 inhibitory signaling", "G beta:gamma signalling through PI3Kgamma", "VEGFR2 mediated vascular permeability", "Regulation of TP53 Degradation", "Regulation of TP53 Activity through Acetylation"], "25235": ["Prolactin receptor signaling", "Growth hormone receptor signaling"], "25237": ["Signaling by BMP"], "25240": ["Erythrocytes take up carbon dioxide and release oxygen", "Vasopressin regulates renal water homeostasis via Aquaporins", "Passive transport by Aquaporins"], "25241": ["Passive transport by Aquaporins"], "25243": ["Phase I - Functionalization of compounds", "Endogenous sterols", "Xenobiotics", "Aryl hydrocarbon receptor signalling"], "25245": ["Peptide ligand-binding receptors", "G alpha (q) signalling events", "G alpha (i) signalling events"], "25246": ["Degradation of the extracellular matrix", "Basigin interactions", "Integrin cell surface interactions", "Proton-coupled monocarboxylate transport", "Pyruvate metabolism"], "25248": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (i) signalling events"], "25255": ["G0 and Early G1"], "25256": ["FMO oxidises nucleophiles"], "25257": ["Creatine metabolism"], "25261": ["Oncogene Induced Senescence"], "25262": ["Effects of PIP2 hydrolysis", "Elevation of cytosolic Ca2+ levels", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "cGMP effects", "Ion homeostasis", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "25265": ["G alpha (q) signalling events", "P2Y receptors", "ADP signalling through P2Y purinoceptor 1"], "25266": ["Platelet degranulation ", "PIP3 activates AKT signaling", "Downstream signal transduction", "Signaling by PDGF", "Non-integrin membrane-ECM interactions", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "25267": ["PIP3 activates AKT signaling", "Downstream signal transduction", "Signaling by PDGF", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "25268": ["Intrinsic Pathway of Fibrin Clot Formation", "Common Pathway of Fibrin Clot Formation", "Gamma-carboxylation of protein precursors", "Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "Removal of aminoterminal propeptides from gamma-carboxylated proteins", "Cell surface interactions at the vascular wall", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "25270": ["ABC transporters in lipid homeostasis"], "25271": ["Recycling of bile acids and salts", "Synthesis of bile acids and bile salts", "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "Import of palmitoyl-CoA into the mitochondrial matrix", "Regulation of pyruvate dehydrogenase (PDH) complex", "Endogenous sterols", "Transcriptional regulation of white adipocyte differentiation", "Nuclear Receptor transcription pathway", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)", "SUMOylation of intracellular receptors", "Signaling by Retinoic Acid"], "25272": ["Oxidative Stress Induced Senescence", "FCERI mediated MAPK activation", "JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1", "Activation of the AP-1 family of transcription factors"], "25274": ["Degradation of cysteine and homocysteine"], "25277": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "25279": ["Vitamin D (calciferol) metabolism"], "25280": ["Sialic acid metabolism"], "25281": ["Transport of Mature mRNA derived from an Intron-Containing Transcript", "SUMOylation of DNA damage response and repair proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of DNA replication proteins"], "25283": ["Glutathione synthesis and recycling"], "252835": ["Molecules associated with elastic fibres"], "25284": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Peroxisomal protein import"], "25285": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "252853": ["COPII-mediated vesicle transport"], "252854": ["Inositol transporters"], "25287": ["Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA"], "252879": ["Recruitment of mitotic centrosome proteins and complexes"], "25288": ["alpha-linolenic acid (ALA) metabolism", "Synthesis of very long-chain fatty acyl-CoAs"], "252881": ["Insulin processing", "VxPx cargo-targeting to cilium"], "252889": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "25289": ["PKA activation", "Adenylate cyclase activating pathway", "Adenylate cyclase inhibitory pathway", "Adrenaline,noradrenaline inhibits insulin secretion", "G alpha (z) signalling events", "Hedgehog 'off' state"], "252892": ["LGI-ADAM interactions"], "252898": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Beta-oxidation of pristanoyl-CoA", "Peroxisomal protein import"], "25290": ["Synthesis of 5-eicosatetraenoic acids", "Synthesis of Leukotrienes (LT) and Eoxins (EX)", "Synthesis of Lipoxins (LX)", "Neutrophil degranulation", "Biosynthesis of E-series 18(S)-resolvins"], "252900": ["Acyl chain remodeling of DAG and TAG", "Triglyceride biosynthesis"], "252916": ["RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "252917": ["Nuclear Receptor transcription pathway"], "252919": ["Amino acid transport across the plasma membrane"], "25292": ["VLDL assembly", "VLDL clearance"], "252921": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "252924": ["Nuclear Receptor transcription pathway"], "252929": ["Metabolism of Angiotensinogen to Angiotensins", "COPII-mediated vesicle transport", "Lysosome Vesicle Biogenesis", "Cargo concentration in the ER", "Neutrophil degranulation"], "25293": ["Vasopressin regulates renal water homeostasis via Aquaporins", "Passive transport by Aquaporins"], "252939": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "25294": ["Miscellaneous transport and binding events"], "25295": ["Gamma-carboxylation of protein precursors", "Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "Removal of aminoterminal propeptides from gamma-carboxylated proteins"], "25296": ["Molecules associated with elastic fibres", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "252961": ["Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon"], "252963": ["Interleukin-4 and Interleukin-13 signaling"], "25297": ["Presynaptic depolarization and calcium channel opening", "Regulation of insulin secretion", "Phase 0 - rapid depolarisation", "Phase 2 - plateau phase"], "252971": ["Interleukin-4 and Interleukin-13 signaling", "Interferon gamma signaling", "Regulation of IFNG signaling", "Interferon alpha/beta signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "25298": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "25300": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "PD-1 signaling"], "25302": ["Highly calcium permeable postsynaptic nicotinic acetylcholine receptors"], "25303": ["ABC-family proteins mediated transport"], "25307": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Neutrophil degranulation", "Post-translational protein phosphorylation"], "25308": ["Neutrophil degranulation"], "25310": ["cGMP effects", "G alpha (s) signalling events"], "25312": ["ECM proteoglycans", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "25315": ["Phase I - Functionalization of compounds"], "25317": ["PI3K Cascade", "PIP3 activates AKT signaling", "FGFR4 ligand binding and activation", "FGFR1b ligand binding and activation", "FGFR3b ligand binding and activation", "FGFR3c ligand binding and activation", "FGFR1c ligand binding and activation", "FGFR2c ligand binding and activation", "FGFR2b ligand binding and activation", "Phospholipase C-mediated cascade: FGFR1", "Phospholipase C-mediated cascade; FGFR2", "Phospholipase C-mediated cascade; FGFR3", "Phospholipase C-mediated cascade; FGFR4", "Downstream signaling of activated FGFR1", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "PI-3K cascade:FGFR3", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "PI-3K cascade:FGFR4", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "25320": ["G alpha (q) signalling events", "Gastrin-CREB signalling pathway via PKC and MAPK"], "25321": ["G alpha (s) signalling events", "Glucagon-type ligand receptors"], "25322": ["Estrogen biosynthesis"], "25323": ["Serotonin receptors", "G alpha (i) signalling events"], "25325": ["Interleukin-10 signaling"], "25326": ["Interleukin-7 signaling", "RAF/MAP kinase cascade", "Interleukin-4 and Interleukin-13 signaling", "Interleukin-20 family signaling", "Interleukin-15 signaling", "Interleukin-9 signaling", "Interleukin-2 signaling", "Interleukin-21 signaling", "Interleukin receptor SHC signaling"], "25327": ["Voltage gated Potassium channels"], "25328": ["Neutrophil degranulation"], "25329": ["Androgen biosynthesis", "Mineralocorticoid biosynthesis", "Glycoprotein hormones", "Hormone ligand-binding receptors", "G alpha (s) signalling events", "TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "Reactions specific to the complex N-glycan synthesis pathway"], "25335": ["Collagen degradation", "Degradation of the extracellular matrix", "Activation of Matrix Metalloproteinases", "Assembly of collagen fibrils and other multimeric structures"], "25340": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "25341": ["TNFs bind their physiological receptors"], "25342": ["Vasopressin-like receptors", "G alpha (q) signalling events"], "25347": ["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "25349": ["Phase 0 - rapid depolarisation"], "25351": ["Cellular hexose transport", "Regulation of insulin secretion", "Intestinal hexose absorption"], "25352": ["Detoxification of Reactive Oxygen Species"], "25353": ["Degradation of the extracellular matrix", "Signaling by PDGF", "Integrin cell surface interactions", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "25354": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "25357": ["Import of palmitoyl-CoA into the mitochondrial matrix"], "25358": ["Platelet degranulation "], "25359": ["Depolymerisation of the Nuclear Lamina"], "25361": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Integrin cell surface interactions"], "25365": ["Smooth Muscle Contraction"], "25366": ["Signaling by Activin", "Signaling by BMP"], "25367": ["C6 deamination of adenosine", "Formation of editosomes by ADAR proteins"], "25368": ["Purine salvage"], "25369": ["Adenosine P1 receptors", "G alpha (s) signalling events", "Surfactant metabolism"], "25370": ["Adenosine P1 receptors", "G alpha (i) signalling events"], "25374": ["Heme biosynthesis", "Neutrophil degranulation"], "25375": ["Phase I - Functionalization of compounds"], "25376": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "25377": ["Scavenging of heme from plasma"], "25378": ["Signaling by BMP"], "25380": ["G alpha (q) signalling events", "G alpha (i) signalling events", "Formyl peptide receptors bind formyl peptides and many other ligands"], "25383": ["mRNA Editing: C to U Conversion", "Formation of the Editosome"], "25385": ["Regulation by c-FLIP", "RIPK1-mediated regulated necrosis", "CASP8 activity is inhibited", "Dimerization of procaspase-8", "FasL/ CD95L signaling"], "25387": ["G alpha (s) signalling events", "Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis", "Thrombin signalling through proteinase activated receptors (PARs)", "Activation of SMO", "MAP2K and MAPK activation", "Ub-specific processing proteases", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "25388": ["G alpha (s) signalling events", "Thrombin signalling through proteinase activated receptors (PARs)", "WNT5A-dependent internalization of FZD4", "Activation of SMO", "MAP2K and MAPK activation", "Ub-specific processing proteases", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "25390": ["Basigin interactions", "Ion homeostasis", "Ion transport by P-type ATPases"], "25391": ["Reduction of cytosolic Ca++ levels", "Ion homeostasis", "Ion transport by P-type ATPases"], "25393": ["Degradation of the extracellular matrix", "A tetrasaccharide linker sequence is required for GAG synthesis", "Chondroitin sulfate biosynthesis", "Dermatan sulfate biosynthesis", "CS/DS degradation", "ECM proteoglycans"], "25402": ["SMAC, XIAP-regulated apoptotic response", "NADE modulates death signalling", "Activation of DNA fragmentation factor", "Caspase-mediated cleavage of cytoskeletal proteins", "Apoptotic cleavage of cell adhesion  proteins", "Caspase activation via Dependence Receptors in the absence of ligand", "Other interleukin signaling"], "25403": ["Degradation of the extracellular matrix"], "25404": ["eNOS activation", "NOSTRIN mediated eNOS trafficking", "Basigin interactions", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "VEGFR2 mediated vascular permeability"], "25405": ["Regulation of TP53 Degradation"], "25406": ["Degradation of the extracellular matrix", "Cell surface interactions at the vascular wall", "Integrin cell surface interactions", "Hyaluronan uptake and degradation", "Neutrophil degranulation"], "25407": ["COPII-mediated vesicle transport", "Cargo concentration in the ER", "Neutrophil degranulation", "COPI-mediated anterograde transport", "Regulation of Complement cascade"], "25408": ["PIP3 activates AKT signaling", "CD28 co-stimulation", "CD28 dependent PI3K/Akt signaling", "CD28 dependent Vav1 pathway", "CTLA4 inhibitory signaling", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "25415": ["CRMPs in Sema3A signaling"], "25416": ["CRMPs in Sema3A signaling", "Recycling pathway of L1"], "25417": ["CRMPs in Sema3A signaling"], "25418": ["CRMPs in Sema3A signaling"], "25420": ["HSF1-dependent transactivation"], "25423": ["COPII-mediated vesicle transport", "MHC class II antigen presentation", "Cargo concentration in the ER", "Neutrophil degranulation"], "25424": ["MHC class II antigen presentation"], "25427": ["Cholesterol biosynthesis", "Endogenous sterols"], "25428": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "Endogenous sterols"], "25432": ["Dopamine receptors", "G alpha (i) signalling events"], "25433": ["Signaling by ERBB2", "Signaling by ERBB4", "SHC1 events in ERBB2 signaling", "PI3K events in ERBB4 signaling", "SHC1 events in ERBB4 signaling", "PIP3 activates AKT signaling", "Signaling by EGFR", "GRB2 events in EGFR signaling", "GAB1 signalosome", "SHC1 events in EGFR signaling", "EGFR downregulation", "GRB2 events in ERBB2 signaling", "PI3K events in ERBB2 signaling", "EGFR interacts with phospholipase C-gamma", "EGFR Transactivation by Gastrin", "RAF/MAP kinase cascade", "ERBB2 Regulates Cell Motility", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "ERBB2 Activates PTK6 Signaling", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "PTK6 promotes HIF1A stabilization", "Downregulation of ERBB2 signaling"], "25435": ["mTORC1-mediated signalling"], "25438": ["Gluconeogenesis"], "25440": ["Recycling of bile acids and salts", "Triglyceride catabolism"], "25441": ["GPVI-mediated activation cascade", "Cell surface interactions at the vascular wall", "Fc epsilon receptor (FCERI) signaling", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "Neutrophil degranulation", "Platelet Adhesion to exposed collagen"], "25443": ["PI3K Cascade", "PIP3 activates AKT signaling", "FGFR1b ligand binding and activation", "FGFR2b ligand binding and activation", "Phospholipase C-mediated cascade: FGFR1", "Phospholipase C-mediated cascade; FGFR2", "Downstream signaling of activated FGFR1", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "FGFRL1 modulation of FGFR1 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "25444": ["PI3K Cascade", "PIP3 activates AKT signaling", "FGFR4 ligand binding and activation", "FGFR3b ligand binding and activation", "FGFR3c ligand binding and activation", "FGFR1c ligand binding and activation", "FGFR2c ligand binding and activation", "Phospholipase C-mediated cascade: FGFR1", "Phospholipase C-mediated cascade; FGFR2", "Phospholipase C-mediated cascade; FGFR3", "Phospholipase C-mediated cascade; FGFR4", "Downstream signaling of activated FGFR1", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "PI-3K cascade:FGFR3", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "PI-3K cascade:FGFR4", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "25447": ["Glycoprotein hormones", "Hormone ligand-binding receptors", "G alpha (s) signalling events"], "25448": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Deposition of new CENPA-containing nucleosomes at the centromere", "Mitotic Prometaphase"], "25449": ["Hormone ligand-binding receptors", "G alpha (s) signalling events"], "25450": ["GABA A receptor activation"], "25451": ["GABA A receptor activation"], "25455": ["Neutrophil degranulation"], "25456": ["Neurotransmitter receptors and postsynaptic signal transmission"], "25458": ["Glutathione synthesis and recycling"], "25464": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Integrin cell surface interactions"], "25466": ["PIP3 activates AKT signaling", "Receptor-type tyrosine-protein phosphatases", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Interleukin-36 pathway", "Interleukin-33 signaling", "Interleukin-1 signaling"], "25468": ["Voltage gated Potassium channels"], "25469": ["Voltage gated Potassium channels"], "25470": ["Voltage gated Potassium channels"], "25471": ["Phase 3 - rapid repolarisation", "Phase 2 - plateau phase"], "25472": ["ATP sensitive Potassium channels"], "25473": ["Laminin interactions", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "MET activates PTK2 signaling", "Post-translational protein phosphorylation"], "25478": ["Intra-Golgi traffic", "Reactions specific to the complex N-glycan synthesis pathway"], "25479": ["WNT ligand biogenesis and trafficking"], "25480": ["Passive transport by Aquaporins"], "25481": ["Degradation of the extracellular matrix", "Activation of Matrix Metalloproteinases"], "25488": ["Respiratory electron transport", "Complex I biogenesis"], "25489": ["ISG15 antiviral mechanism", "Downregulation of ERBB4 signaling", "Regulation of PTEN localization", "Regulation of PTEN stability and activity", "Antigen processing: Ubiquitination & Proteasome degradation"], "25490": ["TGF-beta receptor signaling activates SMADs", "UCH proteinases", "Cargo recognition for clathrin-mediated endocytosis", "Neddylation", "Iron uptake and transport"], "25493": ["Activation of NF-kappaB in B cells", "RIP-mediated NFkB activation via ZBP1", "Downstream TCR signaling", "NF-kB is activated and signals survival", "FCERI mediated NF-kB activation", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "SUMOylation of immune response proteins", "CLEC7A (Dectin-1) signaling", "Ub-specific processing proteases", "Interleukin-1 signaling", "TRAF6 mediated NF-kB activation"], "25494": ["Degradation of the extracellular matrix", "Laminin interactions"], "25495": ["Signaling by BMP"], "25496": ["Pre-NOTCH Processing in Golgi", "NOTCH1 Intracellular Domain Regulates Transcription", "Activated NOTCH1 Transmits Signal to the Nucleus", "Notch-HLH transcription pathway", "RUNX3 regulates NOTCH signaling"], "25504": ["Vasopressin-like receptors", "G alpha (q) signalling events"], "25505": ["Elevation of cytosolic Ca2+ levels", "Platelet homeostasis", "Neutrophil degranulation"], "25506": ["Collagen biosynthesis and modifying enzymes", "Detoxification of Reactive Oxygen Species", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Hedgehog ligand biogenesis", "Post-translational protein phosphorylation", "Chylomicron assembly", "Interleukin-12 signaling"], "25511": ["Synthesis of PC"], "25513": ["PI3K Cascade", "IRS-mediated signalling", "GPVI-mediated activation cascade", "PI3K events in ERBB4 signaling", "PIP3 activates AKT signaling", "Interleukin-7 signaling", "Signaling by SCF-KIT", "Synthesis of PIPs at the plasma membrane", "GAB1 signalosome", "Downstream signal transduction", "PI3K events in ERBB2 signaling", "PI3K/AKT activation", "Downstream TCR signaling", "Role of phospholipids in phagocytosis", "Tie2 Signaling", "DAP12 signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Costimulation by the CD28 family", "CD28 dependent PI3K/Akt signaling", "G alpha (q) signalling events", "GP1b-IX-V activation signalling", "VEGFA-VEGFR2 Pathway", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "PI-3K cascade:FGFR1", "PI-3K cascade:FGFR2", "PI-3K cascade:FGFR3", "PI-3K cascade:FGFR4", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "MET activates PI3K/AKT signaling", "RET signaling", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "Interleukin receptor SHC signaling", "Regulation of signaling by CBL", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "25516": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "25520": ["Formation of the beta-catenin:TCF transactivating complex", "PKMTs methylate histone lysines", "Deactivation of the beta-catenin transactivating complex", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"], "25522": ["TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "VEGFR2 mediated cell proliferation"], "25523": ["Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "cGMP effects"], "25525": ["RAF/MAP kinase cascade", "RET signaling"], "25526": ["Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"], "25528": ["Cell surface interactions at the vascular wall", "DAP12 interactions", "Signal regulatory protein family interactions", "Neutrophil degranulation"], "25531": ["Serotonin Neurotransmitter Release Cycle", "Norepinephrine Neurotransmitter Release Cycle", "Glutamate Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle", "Acetylcholine Neurotransmitter Release Cycle", "Neutrophil degranulation", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs", "GABA synthesis, release, reuptake and degradation"], "25532": ["TBC/RABGAPs", "RAB geranylgeranylation", "MET receptor recycling"], "25537": ["EPHB-mediated forward signaling", "G alpha (12/13) signalling events", "Sema4D induced cell migration and growth-cone collapse", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate ROCKs"], "25538": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "25539": ["Inactivation, recovery and regulation of the phototransduction cascade"], "25544": ["Cell surface interactions at the vascular wall"], "25548": ["Type II Na+/Pi cotransporters", "Surfactant metabolism"], "25549": ["Serotonin Neurotransmitter Release Cycle", "Norepinephrine Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle", "Na+/Cl- dependent neurotransmitter transporters"], "25550": ["Glutamate Neurotransmitter Release Cycle", "Transport of inorganic cations/anions and amino acids/oligopeptides"], "25551": ["Cellular hexose transport", "Vitamin C (ascorbate) metabolism", "Neutrophil degranulation"], "25552": ["Cellular hexose transport", "Intestinal hexose absorption"], "25553": ["Serotonin clearance from the synaptic cleft"], "25555": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "25556": ["PIP3 activates AKT signaling", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Interleukin-33 signaling"], "25557": ["Pregnenolone biosynthesis"], "25558": ["Serotonin Neurotransmitter Release Cycle", "Norepinephrine Neurotransmitter Release Cycle", "Glutamate Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle", "Acetylcholine Neurotransmitter Release Cycle", "GABA synthesis, release, reuptake and degradation"], "25559": ["ATP sensitive Potassium channels", "Regulation of insulin secretion"], "25562": ["Formation of RNA Pol II elongation complex ", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "RNA Polymerase II Transcription Elongation"], "25565": ["Formation of the beta-catenin:TCF transactivating complex", "Deactivation of the beta-catenin transactivating complex", "Repression of WNT target genes"], "25566": ["Striated Muscle Contraction"], "25569": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "25571": ["Vitamin E"], "25572": ["TNFs bind their physiological receptors"], "25573": ["SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of transcription factors", "SUMOylation of ubiquitinylation proteins", "SUMOylation of transcription cofactors", "SUMOylation of SUMOylation proteins", "SUMOylation of intracellular receptors", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA methylation proteins", "SUMOylation of immune response proteins", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Formation of Incision Complex in GG-NER", "Negative regulation of activity of TFAP2 (AP-2) family transcription factors"], "25574": ["RNA Polymerase I Promoter Opening", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase I Transcription Termination"], "25576": ["Activation of BAD and translocation to mitochondria ", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "RHO GTPases activate PKNs", "TP53 Regulates Metabolic Genes", "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex"], "25577": ["Activation of BAD and translocation to mitochondria ", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "RHO GTPases activate PKNs", "TP53 Regulates Metabolic Genes", "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "Regulation of localization of FOXO transcription factors"], "25578": ["Activation of BAD and translocation to mitochondria ", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Deactivation of the beta-catenin transactivating complex", "Rap1 signalling", "GP1b-IX-V activation signalling", "KSRP (KHSRP) binds and destabilizes mRNA", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "RHO GTPases activate PKNs", "TP53 Regulates Metabolic Genes", "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "NOTCH4 Activation and Transmission of Signal to the Nucleus", "Regulation of localization of FOXO transcription factors"], "25584": ["Extrinsic Pathway of Fibrin Clot Formation"], "25586": ["Post-translational modification: synthesis of GPI-anchored proteins"], "25591": ["POLB-Dependent Long Patch Base Excision Repair", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "SUMOylation of DNA damage response and repair proteins", "HDR through MMEJ (alt-NHEJ)", "DNA Damage Recognition in GG-NER", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER"], "25593": ["Orexin and neuropeptides FF and QRFP bind to their respective receptors", "G alpha (q) signalling events"], "25594": ["Regulation of PLK1 Activity at G2/M Transition", "RHO GTPases activate PKNs", "RHO GTPases activate PAKs"], "25597": ["Regulation of RAS by GAPs"], "25599": ["Cell surface interactions at the vascular wall", "MHC class II antigen presentation"], "25601": ["Opioid Signalling", "G-protein activation", "Peptide ligand-binding receptors", "G alpha (i) signalling events"], "25603": ["Acetylcholine regulates insulin secretion"], "25605": ["Orexin and neuropeptides FF and QRFP bind to their respective receptors", "G alpha (q) signalling events"], "25608": ["Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "Synthesis, secretion, and deacylation of Ghrelin"], "25611": ["Mitochondrial protein import", "Urea cycle"], "25612": ["Amino acid synthesis and interconversion (transamination)"], "25613": ["Other interleukin signaling"], "25614": ["Apoptotic cleavage of cellular proteins", "Regulation of actin dynamics for phagocytic cup formation", "Integrin alphaIIb beta3 signaling", "GRB2:SOS provides linkage to MAPK signaling for Integrins ", "p130Cas linkage to MAPK signaling for integrins", "NCAM signaling for neurite out-growth", "EPHB-mediated forward signaling", "DCC mediated attractive signaling", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate WASPs and WAVEs", "RAF/MAP kinase cascade", "MET activates PTK2 signaling"], "25615": ["A tetrasaccharide linker sequence is required for GAG synthesis", "HS-GAG biosynthesis", "HS-GAG degradation", "Cell surface interactions at the vascular wall", "Syndecan interactions", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "EPHB-mediated forward signaling", "Post-translational protein phosphorylation", "Retinoid metabolism and transport"], "25616": ["G alpha (s) signalling events", "Relaxin receptors"], "25617": ["Regulation of HSF1-mediated heat shock response", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "25619": ["Neutrophil degranulation", "Dissolution of Fibrin Clot"], "25621": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Regulation of Complement cascade"], "25622": ["Interleukin-6 signaling", "PI3K Cascade", "MAPK3 (ERK1) activation", "MAPK1 (ERK2) activation", "GPVI-mediated activation cascade", "PIP3 activates AKT signaling", "Signaling by SCF-KIT", "GAB1 signalosome", "Downstream signal transduction", "Tie2 Signaling", "Costimulation by the CD28 family", "CTLA4 inhibitory signaling", "PD-1 signaling", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "FRS-mediated FGFR2 signaling", "FRS-mediated FGFR3 signaling", "PI-3K cascade:FGFR3", "FRS-mediated FGFR4 signaling", "PI-3K cascade:FGFR4", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "RET signaling", "Interleukin-20 family signaling", "MET activates PTPN11", "Regulation of RUNX1 Expression and Activity", "Interferon alpha/beta signaling", "Regulation of IFNA signaling", "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon"], "25623": ["Glycogen synthesis"], "25626": ["Keratinization", "Formation of the cornified envelope"], "25627": ["Signaling by SCF-KIT", "Activation of Matrix Metalloproteinases", "Metabolism of Angiotensinogen to Angiotensins"], "25630": ["Neutrophil degranulation", "Glycolysis"], "25631": ["Signaling by NODAL", "Signaling by Activin", "Downregulation of TGF-beta receptor signaling", "TGF-beta receptor signaling activates SMADs", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Ub-specific processing proteases", "RUNX3 regulates CDKN1A transcription", "FOXO-mediated transcription of cell cycle genes"], "25632": ["Erythrocytes take up carbon dioxide and release oxygen", "Erythrocytes take up oxygen and release carbon dioxide", "Scavenging of heme from plasma"], "25634": ["Gluconeogenesis"], "25635": ["Peptide ligand-binding receptors", "G alpha (s) signalling events"], "25636": ["PKA activation", "PKA activation in glucagon signalling", "DARPP-32 events", "Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Rap1 signalling", "Regulation of insulin secretion", "Vasopressin regulates renal water homeostasis via Aquaporins", "VEGFA-VEGFR2 Pathway", "CREB1 phosphorylation through the activation of Adenylate Cyclase", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'off' state", "Anchoring of the basal body to the plasma membrane", "CD209 (DC-SIGN) signaling", "MAPK6/MAPK4 signaling", "AURKA Activation by TPX2", "HDL assembly", "Factors involved in megakaryocyte development and platelet production"], "25637": ["Prostanoid ligand receptors", "G alpha (q) signalling events"], "25639": ["TGF-beta receptor signaling activates SMADs"], "25641": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "25642": ["Miscellaneous substrates", "Xenobiotics", "Aflatoxin activation and detoxification", "Biosynthesis of maresin-like SPMs"], "25643": ["PLC beta mediated events", "Adenylate cyclase inhibitory pathway", "G-protein activation", "ADP signalling through P2Y purinoceptor 12", "G alpha (i) signalling events", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "25645": ["Adrenoceptors", "G alpha (s) signalling events"], "25649": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation", "Chylomicron assembly", "Chylomicron remodeling", "Retinoid metabolism and transport"], "25650": ["Basigin interactions", "Ion homeostasis", "Ion transport by P-type ATPases"], "25651": ["Platelet degranulation ", "Cell surface interactions at the vascular wall"], "25652": ["Prostanoid ligand receptors", "G alpha (q) signalling events"], "25653": ["Glycoprotein hormones", "Thyroxine biosynthesis", "Hormone ligand-binding receptors", "G alpha (s) signalling events"], "25654": ["Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Assembly of collagen fibrils and other multimeric structures", "Non-integrin membrane-ECM interactions", "MET activates PTK2 signaling", "Collagen chain trimerization"], "25655": ["Gap junction assembly"], "25656": ["Digestion"], "25658": ["Regulation of Glucokinase by Glucokinase Regulatory Protein"], "25659": ["Fructose catabolism"], "25661": ["Platelet degranulation ", "Degradation of the extracellular matrix", "Extracellular matrix organization", "Fibronectin matrix formation", "Cell surface interactions at the vascular wall", "Molecules associated with elastic fibres", "Integrin cell surface interactions", "Syndecan interactions", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "Integrin alphaIIb beta3 signaling", "GRB2:SOS provides linkage to MAPK signaling for Integrins ", "p130Cas linkage to MAPK signaling for integrins", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "MAP2K and MAPK activation", "MET activates PTK2 signaling", "Post-translational protein phosphorylation"], "25662": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "25663": ["Interleukin-1 signaling"], "25664": ["Transcriptional regulation of white adipocyte differentiation", "Nuclear Receptor transcription pathway"], "25665": ["Phase 0 - rapid depolarisation"], "25666": ["Effects of PIP2 hydrolysis"], "25668": ["Nicotinate metabolism"], "25670": ["Interleukin-15 signaling"], "25673": ["Platelet degranulation "], "25674": ["Neurotransmitter receptors and postsynaptic signal transmission"], "25675": ["Cholesterol biosynthesis"], "25678": ["Non-integrin membrane-ECM interactions"], "25679": ["Effects of PIP2 hydrolysis", "Elevation of cytosolic Ca2+ levels", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Ion homeostasis", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "25680": ["Digestion of dietary lipid", "Retinoid metabolism and transport"], "25681": ["Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Assembly of collagen fibrils and other multimeric structures", "Non-integrin membrane-ECM interactions", "Collagen chain trimerization"], "25682": ["Import of palmitoyl-CoA into the mitochondrial matrix", "Regulation of pyruvate dehydrogenase (PDH) complex", "Nuclear Receptor transcription pathway", "Signaling by Retinoic Acid"], "25685": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "25686": ["PLC beta mediated events", "Adenylate cyclase inhibitory pathway", "G-protein activation", "ADP signalling through P2Y purinoceptor 12", "Adrenaline,noradrenaline inhibits insulin secretion", "G alpha (i) signalling events", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "25689": ["Serotonin receptors", "G alpha (i) signalling events"], "25690": ["Phase I - Functionalization of compounds", "Endogenous sterols", "Xenobiotics", "Aryl hydrocarbon receptor signalling"], "25692": ["Signaling by PDGF", "Dissolution of Fibrin Clot"], "25693": ["Na+/Cl- dependent neurotransmitter transporters"], "25694": ["Hyaluronan biosynthesis and export"], "25696": ["Reelin signalling pathway", "VLDLR internalisation and degradation", "VLDL clearance"], "25697": ["Activation of Matrix Metalloproteinases", "Trafficking and processing of endosomal TLR", "Assembly of collagen fibrils and other multimeric structures", "MHC class II antigen presentation", "RUNX1 regulates transcription of genes involved in differentiation of keratinocytes"], "25698": ["Urea cycle"], "25700": ["Ub-specific processing proteases", "Peroxisomal protein import"], "25703": ["The canonical retinoid cycle in rods (twilight vision)", "Retinoid metabolism and transport"], "25704": ["RAF/MAP kinase cascade", "Interleukin-2 signaling", "Interleukin receptor SHC signaling"], "25708": ["The fatty acid cycling model", "The proton buffering model"], "25709": ["Heme biosynthesis"], "25710": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "PD-1 signaling", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "25711": ["Digestion"], "25712": ["Interferon gamma signaling", "Regulation of IFNG signaling"], "25713": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Integrin cell surface interactions"], "25714": ["CDO in myogenesis"], "25715": ["Metal ion SLC transporters", "Iron uptake and transport"], "25716": ["Serotonin Neurotransmitter Release Cycle", "Norepinephrine Neurotransmitter Release Cycle", "Glutamate Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle", "Acetylcholine Neurotransmitter Release Cycle", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "GABA synthesis, release, reuptake and degradation"], "25717": ["Platelet degranulation ", "Molecules associated with elastic fibres"], "25720": ["CDO in myogenesis", "RUNX1 regulates transcription of genes involved in differentiation of HSCs"], "25721": ["Glyoxylate metabolism and glycine degradation", "Amino acid synthesis and interconversion (transamination)"], "25722": ["Phase 0 - rapid depolarisation"], "25723": ["Orexin and neuropeptides FF and QRFP bind to their respective receptors", "G alpha (q) signalling events"], "25725": ["PKA activation", "PKA activation in glucagon signalling", "DARPP-32 events", "Vasopressin regulates renal water homeostasis via Aquaporins", "CREB1 phosphorylation through the activation of Adenylate Cyclase", "Hedgehog 'off' state", "Factors involved in megakaryocyte development and platelet production"], "25726": ["Peptide ligand-binding receptors", "G alpha (s) signalling events"], "25728": ["Scavenging by Class A Receptors", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation", "Chylomicron assembly", "Chylomicron remodeling", "Chylomicron clearance", "HDL remodeling", "Retinoid metabolism and transport"], "25729": ["G0 and Early G1", "SCF(Skp2)-mediated degradation of p27/p21", "DNA Damage/Telomere Stress Induced Senescence", "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "CDK-mediated phosphorylation and removal of Cdc6", "Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes", "Cyclin E associated events during G1/S transition ", "p53-Dependent G1 DNA Damage Response", "PTK6 Regulates Cell Cycle"], "25730": ["Activated NTRK2 signals through PLCG1", "Activated NTRK2 signals through FRS2 and FRS3"], "25732": ["Vitamin B2 (riboflavin) metabolism"], "25734": ["FCGR activation", "Regulation of signaling by CBL"], "25735": ["Nuclear Receptor transcription pathway"], "25736": ["Voltage gated Potassium channels", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion"], "25737": ["Translesion synthesis by REV1", "Recognition of DNA damage by PCNA-containing replication complex", "Translesion Synthesis by POLH", "Polymerase switching on the C-strand of the telomere", "Processive synthesis on the C-strand of the telomere", "Telomere C-strand (Lagging Strand) Synthesis", "Removal of the Flap Intermediate from the C-strand", "SUMOylation of DNA replication proteins", "Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "PCNA-Dependent Long Patch Base Excision Repair", "Translesion synthesis by POLK", "Translesion synthesis by POLI", "Termination of translesion DNA synthesis", "HDR through Homologous Recombination (HRR)", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "Polymerase switching", "Removal of the Flap Intermediate", "Processive synthesis on the lagging strand", "E3 ubiquitin ligases ubiquitinate target proteins"], "25740": ["PLC beta mediated events", "G-protein activation", "G alpha (z) signalling events", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "25741": ["Neutrophil degranulation", "Glycolysis"], "25742": ["TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "Advanced glycosylation endproduct receptor signaling", "TRAF6 mediated NF-kB activation"], "25743": ["Activation of G protein gated Potassium channels", "Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "25744": ["Regulation of actin dynamics for phagocytic cup formation", "RHO GTPases activate PAKs"], "25745": ["Regulation of actin dynamics for phagocytic cup formation", "RHO GTPases activate PAKs"], "25746": ["RAF/MAP kinase cascade", "Interleukin-15 signaling", "Interleukin-2 signaling", "Interleukin receptor SHC signaling"], "25747": ["Nuclear Receptor transcription pathway", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)", "SUMOylation of intracellular receptors"], "25749": ["Stimuli-sensing channels"], "25750": ["Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB"], "25751": ["Gap junction degradation", "Formation of annular gap junctions", "NOSTRIN mediated eNOS trafficking", "MHC class II antigen presentation", "Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis", "Recycling pathway of L1", "Clathrin-mediated endocytosis"], "25757": ["Import of palmitoyl-CoA into the mitochondrial matrix", "Signaling by Retinoic Acid"], "257644": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "259171": ["Nonhomologous End-Joining (NHEJ)"], "259222": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "259224": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "259235": ["The canonical retinoid cycle in rods (twilight vision)"], "259237": ["Factors involved in megakaryocyte development and platelet production"], "259241": ["Nuclear Receptor transcription pathway"], "259242": ["Regulation of actin dynamics for phagocytic cup formation", "RHO GTPases Activate WASPs and WAVEs"], "259243": ["Phase 1 - inactivation of fast Na+ channels"], "259274": ["Inactivation, recovery and regulation of the phototransduction cascade", "Activation, myristolyation of BID and translocation to mitochondria"], "259275": ["Neutrophil degranulation"], "260319": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "260320": ["Extrinsic Pathway of Fibrin Clot Formation", "Gamma-carboxylation of protein precursors", "Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "Removal of aminoterminal propeptides from gamma-carboxylated proteins"], "260321": ["HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Attenuation phase", "ESR-mediated signaling", "Estrogen-dependent gene expression"], "261730": ["APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Regulation of PLK1 Activity at G2/M Transition", "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "Regulation of TP53 Activity through Phosphorylation", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "AURKA Activation by TPX2", "Interaction between PHLDA1 and AURKA"], "261736": ["DNA Damage Recognition in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Cargo recognition for clathrin-mediated endocytosis", "Neddylation"], "26193": ["Respiratory electron transport", "Complex I biogenesis"], "26194": ["Respiratory electron transport", "Complex I biogenesis"], "26196": ["Formation of ATP by chemiosmotic coupling", "Cristae formation"], "26197": ["Formation of ATP by chemiosmotic coupling", "Cristae formation"], "26199": ["Respiratory electron transport", "Complex I biogenesis"], "26201": ["Respiratory electron transport", "Complex I biogenesis"], "26202": ["Respiratory electron transport", "Complex I biogenesis"], "26203": ["Respiratory electron transport", "Complex I biogenesis"], "26295": ["HATs acetylate histones", "UCH proteinases"], "266601": ["Pink/Parkin Mediated Mitophagy", "Ub-specific processing proteases"], "266606": ["Cargo recognition for clathrin-mediated endocytosis"], "266610": ["Regulation by c-FLIP", "RIPK1-mediated regulated necrosis", "CASP8 activity is inhibited", "TNFR1-induced proapoptotic signaling", "Dimerization of procaspase-8", "FasL/ CD95L signaling", "TRAIL  signaling"], "266612": ["Bicarbonate transporters"], "266674": ["Fatty acids", "Miscellaneous substrates", "Eicosanoids", "Synthesis of Leukotrienes (LT) and Eoxins (EX)", "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)"], "266686": ["RA biosynthesis pathway", "Peroxisomal protein import"], "266688": ["TBC/RABGAPs", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "266689": ["Fatty acids", "Miscellaneous substrates", "Eicosanoids", "Synthesis of Leukotrienes (LT) and Eoxins (EX)"], "266704": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "266706": ["Electric Transmission Across Gap Junctions", "Gap junction assembly"], "266707": ["Gap junction assembly"], "266712": ["E3 ubiquitin ligases ubiquitinate target proteins"], "266713": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of Incision Complex in GG-NER", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "Cyclin A/B1/B2 associated events during G2/M transition", "mRNA Capping", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase I Transcription Termination", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE", "RUNX1 regulates transcription of genes involved in differentiation of HSCs"], "266714": ["The canonical retinoid cycle in rods (twilight vision)"], "266729": ["Reelin signalling pathway"], "266730": ["Stimuli-sensing channels"], "266732": ["LDL clearance"], "266761": ["Endogenous sterols", "The canonical retinoid cycle in rods (twilight vision)"], "266767": ["Organic anion transporters"], "266774": ["Generic Transcription Pathway"], "266787": ["Formation of RNA Pol II elongation complex ", "RNA Polymerase II Pre-transcription Events", "RNA Polymerase II Transcription Elongation"], "266805": ["Hyaluronan biosynthesis and export"], "266807": ["Thyroxine biosynthesis"], "266809": ["Anchoring of the basal body to the plasma membrane"], "266997": ["G alpha (s) signalling events", "G alpha (i) signalling events", "Relaxin receptors"], "266998": ["Sodium-coupled sulphate, di- and tri-carboxylate transporters"], "26759": ["Mitochondrial Fatty Acid Beta-Oxidation"], "27150": ["Voltage gated Potassium channels"], "276720": ["Classical Kir channels", "Phase 4 - resting membrane potential"], "282581": ["Ca2+ pathway", "PCP/CE pathway", "Regulation of FZD by ubiquitination"], "282582": ["WNT ligand biogenesis and trafficking", "PCP/CE pathway"], "282583": ["Molecules associated with elastic fibres"], "282584": ["Synthesis of PIPs at the plasma membrane"], "282636": ["Synthesis of IP2, IP, and Ins in the cytosol"], "282712": ["Amino acid transport across the plasma membrane", "Na+/Cl- dependent neurotransmitter transporters"], "282821": ["Hyaluronan biosynthesis and export"], "282822": ["Effects of PIP2 hydrolysis", "Elevation of cytosolic Ca2+ levels", "TRP channels"], "282827": ["Aryl hydrocarbon receptor signalling"], "282832": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "282834": ["Macroautophagy", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "282838": ["Glycosphingolipid metabolism", "Neutrophil degranulation"], "282839": ["Peptide ligand-binding receptors", "G alpha (s) signalling events"], "282843": ["Smooth Muscle Contraction"], "282844": ["Regulation of TP53 Degradation"], "282845": ["Regulation of TP53 Degradation", "Antigen processing: Ubiquitination & Proteasome degradation"], "28298": ["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "286758": ["Passive transport by Aquaporins"], "286761": ["Ovarian tumor domain proteases"], "286896": ["Sphingolipid de novo biosynthesis"], "286897": ["PKMTs methylate histone lysines", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"], "286898": ["Neutrophil degranulation", "LDL clearance"], "286899": ["Attenuation phase", "HSF1-dependent transactivation"], "286905": ["Fatty acids", "Miscellaneous substrates", "Eicosanoids", "Synthesis of Leukotrienes (LT) and Eoxins (EX)"], "286906": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "286908": ["RET signaling"], "286916": ["Collagen degradation", "Degradation of the extracellular matrix", "Trafficking and processing of endosomal TLR", "Assembly of collagen fibrils and other multimeric structures", "MHC class II antigen presentation", "RUNX1 regulates transcription of genes involved in differentiation of keratinocytes"], "286917": ["RNA polymerase II transcribes snRNA genes"], "286918": ["ISG15 antiviral mechanism"], "286919": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "286920": ["Stimuli-sensing channels"], "286923": ["Neurexins and neuroligins"], "286924": ["PLC beta mediated events", "Adenylate cyclase inhibitory pathway", "G-protein activation", "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "ADP signalling through P2Y purinoceptor 12", "G alpha (i) signalling events", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "286936": ["Synthesis of PC"], "286953": ["Fatty acids", "Xenobiotics", "CYP2E1 reactions"], "286954": ["Glucuronidation"], "286958": ["Defensins", "Alpha-defensins", "Neutrophil degranulation"], "286959": ["Olfactory Signaling Pathway"], "286964": ["The canonical retinoid cycle in rods (twilight vision)"], "286970": ["ABC transporters in lipid homeostasis"], "286973": ["mRNA Splicing - Major Pathway"], "286974": ["Chondroitin sulfate biosynthesis"], "286976": ["O-linked glycosylation of mucins"], "286994": ["Regulation of FZD by ubiquitination"], "286995": ["Defensins", "Alpha-defensins", "Neutrophil degranulation"], "287000": ["Olfactory Signaling Pathway"], "287009": ["Fibronectin matrix formation", "Post-translational modification: synthesis of GPI-anchored proteins", "Cell surface interactions at the vascular wall", "Neutrophil degranulation"], "287034": ["TNFs bind their physiological receptors"], "287054": ["Protein methylation"], "287063": ["Urea cycle"], "287076": ["Generic Transcription Pathway"], "287081": ["Olfactory Signaling Pathway"], "287082": ["Olfactory Signaling Pathway"], "287083": ["Olfactory Signaling Pathway"], "287084": ["Olfactory Signaling Pathway"], "287086": ["Olfactory Signaling Pathway"], "287090": ["Olfactory Signaling Pathway"], "287093": ["Olfactory Signaling Pathway"], "287094": ["Generic Transcription Pathway"], "287095": ["Generic Transcription Pathway"], "287101": ["Polo-like kinase mediated events", "Cyclin A/B1/B2 associated events during G2/M transition", "G2/M DNA replication checkpoint"], "287102": ["Negative regulation of TCF-dependent signaling by WNT ligand antagonists"], "287113": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "287120": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "287122": ["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "287126": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "287155": ["Downregulation of TGF-beta receptor signaling", "Downregulation of ERBB2 signaling", "Regulation of RUNX2 expression and activity", "Regulation of PTEN stability and activity", "Antigen processing: Ubiquitination & Proteasome degradation"], "287156": ["Rho GTPase cycle"], "287159": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "287167": ["Erythrocytes take up carbon dioxide and release oxygen", "Erythrocytes take up oxygen and release carbon dioxide", "Scavenging of heme from plasma"], "287170": ["mRNA Splicing - Minor Pathway"], "287232": ["Olfactory Signaling Pathway"], "287236": ["Olfactory Signaling Pathway"], "287262": ["Olfactory Signaling Pathway"], "287275": ["COPII-mediated vesicle transport", "MHC class II antigen presentation", "Cargo concentration in the ER", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "287276": ["COPII-mediated vesicle transport", "MHC class II antigen presentation", "Cargo concentration in the ER", "Chylomicron assembly", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "287280": ["Activation of NF-kappaB in B cells", "Prolactin receptor signaling", "SCF-beta-TrCP mediated degradation of Emi1", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of PLK1 Activity at G2/M Transition", "FCERI mediated NF-kB activation", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "NIK-->noncanonical NF-kB signaling", "MAP3K8 (TPL2)-dependent MAPK1/3 activation", "Orc1 removal from chromatin", "Cyclin D associated events in G1", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "Regulation of RUNX2 expression and activity", "Neddylation", "Interleukin-1 signaling", "Iron uptake and transport", "Antigen processing: Ubiquitination & Proteasome degradation"], "287287": ["Interleukin-4 and Interleukin-13 signaling"], "287299": ["Molecules associated with elastic fibres"], "287309": ["Olfactory Signaling Pathway"], "287310": ["Olfactory Signaling Pathway"], "287313": ["Olfactory Signaling Pathway"], "287314": ["Olfactory Signaling Pathway"], "287316": ["Olfactory Signaling Pathway"], "287321": ["Olfactory Signaling Pathway"], "287322": ["Olfactory Signaling Pathway"], "287324": ["Olfactory Signaling Pathway"], "287325": ["Olfactory Signaling Pathway"], "287328": ["Olfactory Signaling Pathway"], "287329": ["Olfactory Signaling Pathway"], "287331": ["Olfactory Signaling Pathway"], "287356": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "287361": ["Generic Transcription Pathway"], "287362": ["Metalloprotease DUBs", "The NLRP3 inflammasome"], "287366": ["Synthesis of PA"], "287367": ["DNA Damage Recognition in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Cargo recognition for clathrin-mediated endocytosis", "Neddylation"], "287368": ["Pyrimidine catabolism"], "287379": ["Carnitine synthesis"], "287383": ["Anchoring of the basal body to the plasma membrane"], "287406": ["Phosphate bond hydrolysis by NUDT proteins"], "287417": ["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "287418": ["NRAGE signals death through JNK", "Rho GTPase cycle"], "287419": ["Phase 0 - rapid depolarisation"], "287420": ["Purine ribonucleoside monophosphate biosynthesis"], "287424": ["Synthesis of 12-eicosatetraenoic acid derivatives"], "287427": ["COPII-mediated vesicle transport", "Neutrophil degranulation", "RAB GEFs exchange GTP for GDP on RABs"], "287435": ["Neutrophil degranulation"], "287436": ["ISG15 antiviral mechanism", "L13a-mediated translational silencing of Ceruloplasmin expression", "Deadenylation of mRNA", "Translation initiation complex formation", "Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "287437": ["HuR (ELAVL1) binds and stabilizes mRNA", "TNFs bind their physiological receptors"], "287444": ["Hypusine synthesis from eIF5A-lysine"], "287447": ["Depolymerisation of the Nuclear Lamina"], "287478": ["Transport of inorganic cations/anions and amino acids/oligopeptides", "Miscellaneous transport and binding events"], "287479": ["Pentose phosphate pathway"], "287487": ["Olfactory Signaling Pathway"], "287496": ["Olfactory Signaling Pathway"], "287501": ["Olfactory Signaling Pathway"], "287502": ["Olfactory Signaling Pathway"], "287509": ["Olfactory Signaling Pathway"], "287511": ["Olfactory Signaling Pathway"], "287513": ["Olfactory Signaling Pathway"], "287514": ["Olfactory Signaling Pathway"], "287516": ["Olfactory Signaling Pathway"], "287523": ["Synthesis of diphthamide-EEF2"], "287524": ["Translesion synthesis by REV1", "Recognition of DNA damage by PCNA-containing replication complex", "Translesion Synthesis by POLH", "Removal of the Flap Intermediate from the C-strand", "Activation of ATR in response to replication stress", "SUMOylation of DNA damage response and repair proteins", "Regulation of HSF1-mediated heat shock response", "Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "PCNA-Dependent Long Patch Base Excision Repair", "Translesion synthesis by POLK", "Translesion synthesis by POLI", "Termination of translesion DNA synthesis", "HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Formation of Incision Complex in GG-NER", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Fanconi Anemia Pathway", "Activation of the pre-replicative complex", "Removal of the Flap Intermediate"], "287530": ["mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "287531": ["MHC class II antigen presentation"], "287532": ["Amino acid transport across the plasma membrane"], "287535": ["Retrograde transport at the Trans-Golgi-Network"], "287541": ["Intraflagellar transport"], "287552": ["Antigen processing: Ubiquitination & Proteasome degradation"], "287571": ["RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "287585": ["Transcriptional regulation by RUNX2"], "287593": ["Ub-specific processing proteases"], "287596": ["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "287598": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "287606": ["Release of apoptotic factors from the mitochondria", "SMAC, XIAP-regulated apoptotic response"], "287607": ["Synthesis of PIPs at the early endosome membrane", "Synthesis of PIPs at the late endosome membrane", "Downregulation of TGF-beta receptor signaling"], "287608": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Transcription Elongation"], "287610": ["Events associated with phagocytolytic activity of PMN cells"], "287613": ["Olfactory Signaling Pathway"], "287624": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "COPI-dependent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "Kinesins"], "287634": ["Resolution of D-loop Structures through Holliday Junction Intermediates", "Fanconi Anemia Pathway"], "287635": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "287643": ["Hedgehog 'on' state"], "287644": ["Synthesis of PC", "Synthesis of PE"], "287645": ["Endosomal Sorting Complex Required For Transport (ESCRT)"], "287662": ["SUMOylation of transcription cofactors", "SUMOylation of chromatin organization proteins", "Transcriptional Regulation by E2F6"], "287670": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "Neutrophil degranulation", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "287673": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "287675": ["Keratinization", "Formation of the cornified envelope"], "287679": ["Keratinization", "Formation of the cornified envelope"], "287697": ["Keratinization", "Formation of the cornified envelope"], "287698": ["Keratinization", "Formation of the cornified envelope"], "287699": ["Keratinization", "Formation of the cornified envelope"], "287700": ["Keratinization", "Formation of the cornified envelope"], "287701": ["Keratinization", "Formation of the cornified envelope"], "287702": ["Keratinization", "Formation of the cornified envelope"], "287706": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "287707": ["RIP-mediated NFkB activation via ZBP1", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "TRAF6 mediated NF-kB activation"], "287709": ["Golgi Associated Vesicle Biogenesis", "Neutrophil degranulation", "Clathrin-mediated endocytosis", "RAB geranylgeranylation"], "287710": ["RNA Polymerase I Transcription Termination"], "287711": ["Coenzyme A biosynthesis"], "287715": ["Stimuli-sensing channels"], "287716": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "287721": ["Neutrophil degranulation"], "287739": ["mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "287745": ["Synthesis of IP3 and IP4 in the cytosol"], "287746": ["RHO GTPases Activate Formins"], "287765": ["SUMOylation of transcription cofactors", "mRNA Splicing - Major Pathway", "Estrogen-dependent gene expression"], "287768": ["mRNA Splicing - Major Pathway"], "287772": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "Neutrophil degranulation", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "287774": ["Platelet degranulation "], "287818": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "287830": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA damage response and repair proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of DNA replication proteins", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "287835": ["Galactose catabolism"], "287871": ["Macroautophagy", "mTOR signalling", "mTORC1-mediated signalling", "HSF1-dependent transactivation", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Regulation of PTEN gene transcription"], "287873": ["Macroautophagy", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "287876": ["Gap junction degradation", "Formation of annular gap junctions", "Regulation of actin dynamics for phagocytic cup formation", "EPHB-mediated forward signaling", "Adherens junctions interactions", "Recycling pathway of L1", "VEGFA-VEGFR2 Pathway", "Interaction between L1 and Ankyrins", "Cell-extracellular matrix interactions", "RHO GTPases activate IQGAPs", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate Formins", "MAP2K and MAPK activation", "Clathrin-mediated endocytosis"], "287899": ["Collagen biosynthesis and modifying enzymes", "O-glycosylation of TSR domain-containing proteins"], "287910": ["G alpha (q) signalling events", "G alpha (i) signalling events"], "287920": ["Sialic acid metabolism"], "287927": ["Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Formation of Incision Complex in GG-NER", "G2/M DNA damage checkpoint", "E3 ubiquitin ligases ubiquitinate target proteins", "Antigen processing: Ubiquitination & Proteasome degradation"], "287929": ["Recruitment of mitotic centrosome proteins and complexes", "Recruitment of NuMA to mitotic centrosomes"], "287942": ["Frs2-mediated activation", "Downstream signal transduction", "MET activates RAP1 and RAC1", "MET receptor recycling", "Erythropoietin activates RAS", "Regulation of signaling by CBL"], "287961": ["Activation of ATR in response to replication stress", "Activation of the pre-replicative complex"], "287962": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "287969": ["Olfactory Signaling Pathway"], "287970": ["Olfactory Signaling Pathway"], "287983": ["Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"], "287984": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "Neutrophil degranulation", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "287986": ["ISG15 antiviral mechanism", "L13a-mediated translational silencing of Ceruloplasmin expression", "mTORC1-mediated signalling", "Deadenylation of mRNA", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Translation initiation complex formation", "Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "287989": ["EPH-Ephrin signaling", "EPHB-mediated forward signaling", "Ephrin signaling", "EPH-ephrin mediated repulsion of cells"], "288001": ["Platelet degranulation ", "Intrinsic Pathway of Fibrin Clot Formation", "Peptide ligand-binding receptors", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "G alpha (q) signalling events", "G alpha (i) signalling events", "Post-translational protein phosphorylation"], "288003": ["Translesion synthesis by REV1", "Recognition of DNA damage by PCNA-containing replication complex", "Translesion Synthesis by POLH", "Polymerase switching on the C-strand of the telomere", "Activation of ATR in response to replication stress", "PCNA-Dependent Long Patch Base Excision Repair", "Translesion synthesis by POLK", "Translesion synthesis by POLI", "Termination of translesion DNA synthesis", "HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Polymerase switching"], "288026": ["Ion transport by P-type ATPases"], "288038": ["Post-translational modification: synthesis of GPI-anchored proteins", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "288051": ["Pyrimidine biosynthesis"], "288057": ["Smooth Muscle Contraction", "RHO GTPases activate PAKs"], "288064": ["Activation of DNA fragmentation factor"], "288067": ["Formation of the cornified envelope"], "288075": ["Formation of the cornified envelope"], "288079": ["HDR through MMEJ (alt-NHEJ)"], "288088": ["Respiratory electron transport", "Complex I biogenesis"], "288093": ["Rho GTPase cycle"], "288124": ["Adherens junctions interactions", "Nectin/Necl  trans heterodimerization"], "288174": ["Neutrophil degranulation"], "288181": ["G alpha (s) signalling events"], "288187": ["Olfactory Signaling Pathway"], "288190": ["Olfactory Signaling Pathway"], "288192": ["Olfactory Signaling Pathway"], "288196": ["Olfactory Signaling Pathway"], "288199": ["Olfactory Signaling Pathway"], "288238": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "288259": ["Purine ribonucleoside monophosphate biosynthesis"], "288264": ["Interferon alpha/beta signaling", "Regulation of IFNA signaling"], "288297": ["Keratinization"], "288305": ["Association of TriC/CCT with target proteins during biosynthesis", "Neutrophil degranulation", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "288309": ["Methylation", "Eukaryotic Translation Termination"], "288322": ["Synthesis of PA"], "288371": ["TRP channels", "Transferrin endocytosis and recycling"], "288378": ["CD209 (DC-SIGN) signaling", "Butyrophilin (BTN) family interactions"], "288414": ["Translesion synthesis by REV1", "Recognition of DNA damage by PCNA-containing replication complex", "Translesion Synthesis by POLH", "Polymerase switching on the C-strand of the telomere", "Activation of ATR in response to replication stress", "PCNA-Dependent Long Patch Base Excision Repair", "Translesion synthesis by POLK", "Translesion synthesis by POLI", "Termination of translesion DNA synthesis", "HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Polymerase switching"], "288444": ["Regulation of HSF1-mediated heat shock response"], "288479": ["Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)"], "288482": ["Ub-specific processing proteases"], "288498": ["Macroautophagy"], "288516": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "288521": ["Cell surface interactions at the vascular wall", "Basigin interactions"], "288532": ["Activation of ATR in response to replication stress", "Assembly of the pre-replicative complex", "Orc1 removal from chromatin", "Activation of the pre-replicative complex", "Switching of origins to a post-replicative state"], "288533": ["RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "288549": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "288562": ["Transferrin endocytosis and recycling"], "288563": ["RMTs methylate histone arginines", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "288583": ["Collagen biosynthesis and modifying enzymes"], "288585": ["Intraflagellar transport"], "288588": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Transcriptional regulation by small RNAs", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE", "Estrogen-dependent gene expression"], "288589": ["Regulation of RAS by GAPs"], "288596": ["Antigen processing: Ubiquitination & Proteasome degradation"], "288599": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "288617": ["Cytosolic sulfonation of small molecules"], "288620": ["Association of TriC/CCT with target proteins during biosynthesis", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "288621": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "288626": ["Activation of Matrix Metalloproteinases"], "288647": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "288651": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "mRNA Capping", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase I Transcription Termination", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE"], "288659": ["Endosomal Sorting Complex Required For Transport (ESCRT)"], "288666": ["WNT ligand biogenesis and trafficking"], "288669": ["Regulation of actin dynamics for phagocytic cup formation", "EPHB-mediated forward signaling", "RHO GTPases Activate WASPs and WAVEs", "Clathrin-mediated endocytosis"], "288671": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6", "Antigen processing: Ubiquitination & Proteasome degradation"], "288691": ["MAP2K and MAPK activation"], "288692": ["Neddylation"], "288700": ["TBC/RABGAPs", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "288701": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing"], "288707": ["Glycosphingolipid metabolism"], "288740": ["Mitochondrial iron-sulfur cluster biogenesis"], "288752": ["Keratan sulfate biosynthesis", "O-linked glycosylation of mucins"], "288753": ["Release of apoptotic factors from the mitochondria", "SMAC (DIABLO) binds to IAPs ", "SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ", "SMAC, XIAP-regulated apoptotic response"], "288774": ["Interleukin-20 family signaling", "Interferon alpha/beta signaling", "Regulation of IFNA signaling"], "288778": ["Neutrophil degranulation"], "288779": ["Neutrophil degranulation", "Clathrin-mediated endocytosis", "RAB geranylgeranylation"], "288783": ["Sphingolipid de novo biosynthesis"], "288785": ["Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis"], "288810": ["Olfactory Signaling Pathway"], "288813": ["Olfactory Signaling Pathway"], "288816": ["Olfactory Signaling Pathway"], "288823": ["Olfactory Signaling Pathway"], "288858": ["Olfactory Signaling Pathway"], "288886": ["Olfactory Signaling Pathway"], "288887": ["Olfactory Signaling Pathway"], "288905": ["Interleukin-35 Signalling", "Interleukin-27 signaling"], "288912": ["Methionine salvage pathway"], "288916": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "288919": ["XBP1(S) activates chaperone genes"], "288921": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "288923": ["Hypusine synthesis from eIF5A-lysine"], "288937": ["Dissolution of Fibrin Clot"], "288995": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (q) signalling events", "G alpha (s) signalling events"], "289007": ["O-glycosylation of TSR domain-containing proteins"], "289021": ["Synthesis of PIPs at the plasma membrane"], "289023": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "289026": ["Deactivation of the beta-catenin transactivating complex"], "289032": ["Digestion of dietary carbohydrate", "Neutrophil degranulation"], "289036": ["AMPK inhibits chREBP transcriptional activation activity"], "289051": ["RAB GEFs exchange GTP for GDP on RABs"], "289055": ["Common Pathway of Fibrin Clot Formation"], "289057": ["Regulation of Complement cascade"], "289125": ["Mitochondrial Fatty Acid Beta-Oxidation"], "289143": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "289150": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Deposition of new CENPA-containing nucleosomes at the centromere", "Mitotic Prometaphase"], "289180": ["Hedgehog 'off' state", "Hedgehog 'on' state"], "289181": ["Neddylation"], "289185": ["Neutrophil degranulation"], "289197": ["Glutathione conjugation"], "289211": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Neutrophil degranulation"], "289217": ["Citric acid cycle (TCA cycle)"], "289218": ["Respiratory electron transport", "Complex I biogenesis"], "289219": ["Heme biosynthesis"], "289231": ["Regulated proteolysis of p75NTR", "NRIF signals cell death from the nucleus", "Neutrophil degranulation", "NOTCH3 Activation and Transmission of Signal to the Nucleus"], "289233": ["ABC transporters in lipid homeostasis"], "289240": ["Olfactory Signaling Pathway"], "289241": ["Olfactory Signaling Pathway"], "289250": ["Olfactory Signaling Pathway"], "289251": ["Olfactory Signaling Pathway"], "289254": ["Olfactory Signaling Pathway"], "289255": ["Olfactory Signaling Pathway"], "289257": ["NCAM signaling for neurite out-growth", "Interaction between L1 and Ankyrins", "RAF/MAP kinase cascade", "COPI-mediated anterograde transport"], "289261": ["Olfactory Signaling Pathway"], "289264": ["Signaling by BMP"], "289276": ["Purine ribonucleoside monophosphate biosynthesis"], "289307": ["Mitochondrial transcription initiation"], "289318": ["Neutrophil degranulation"], "289322": ["Sphingolipid de novo biosynthesis", "Neutrophil degranulation"], "289353": ["Metal ion SLC transporters"], "289372": ["PKMTs methylate histone lysines", "Regulation of TP53 Activity through Methylation"], "289382": ["RNA polymerase II transcribes snRNA genes"], "289392": ["Sema3A PAK dependent Axon repulsion", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "CRMPs in Sema3A signaling"], "289395": ["Regulation of Complement cascade"], "289397": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "289407": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "289437": ["Antigen processing: Ubiquitination & Proteasome degradation"], "289443": ["Miscellaneous transport and binding events"], "289453": ["Iron uptake and transport"], "289456": ["Estrogen biosynthesis"], "289459": ["Transport of bile salts and organic acids, metal ions and amine compounds"], "289469": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "289481": ["Triglyceride biosynthesis"], "289508": ["Translesion Synthesis by POLH", "Antigen processing: Ubiquitination & Proteasome degradation"], "289525": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "289561": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Transcriptional regulation by small RNAs", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE", "Estrogen-dependent gene expression"], "289582": ["Cleavage of Growing Transcript in the Termination Region ", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "289594": ["Miscellaneous transport and binding events"], "289603": ["Neddylation"], "289606": ["GABA A receptor activation"], "289608": ["Glycolysis"], "289623": ["Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Antigen processing: Ubiquitination & Proteasome degradation"], "289632": ["Glycogen synthesis", "Neutrophil degranulation", "Pentose phosphate pathway"], "289693": ["mRNA Splicing - Major Pathway"], "289711": ["Hedgehog 'on' state", "Activation of SMO"], "289712": ["Hedgehog 'on' state", "Activation of SMO"], "289717": ["Ub-specific processing proteases"], "289724": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "289727": ["Amino acid synthesis and interconversion (transamination)"], "289733": ["Acyl chain remodelling of PG"], "289736": ["Fatty acyl-CoA biosynthesis"], "289740": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "289747": ["IL-6-type cytokine receptor ligand interactions"], "289757": ["Nonhomologous End-Joining (NHEJ)"], "289758": ["Recognition of DNA damage by PCNA-containing replication complex", "Polymerase switching on the C-strand of the telomere", "Processive synthesis on the C-strand of the telomere", "Telomere C-strand (Lagging Strand) Synthesis", "Removal of the Flap Intermediate from the C-strand", "PCNA-Dependent Long Patch Base Excision Repair", "Termination of translesion DNA synthesis", "HDR through Homologous Recombination (HRR)", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Polymerase switching", "Removal of the Flap Intermediate", "Processive synthesis on the lagging strand"], "289759": ["Smooth Muscle Contraction"], "289801": ["Pyrimidine salvage"], "289809": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "289810": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "289820": ["Regulation of actin dynamics for phagocytic cup formation", "EPHB-mediated forward signaling", "RHO GTPases Activate WASPs and WAVEs", "Neutrophil degranulation", "Clathrin-mediated endocytosis"], "289827": ["Formation of the active cofactor, UDP-glucuronate", "Glycogen synthesis"], "289831": ["Neddylation"], "289874": ["ABC-family proteins mediated transport", "Hedgehog ligand biogenesis"], "289878": ["Activation of the phototransduction cascade", "Inactivation, recovery and regulation of the phototransduction cascade", "Ca2+ pathway"], "289923": ["Olfactory Signaling Pathway"], "289924": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "Neutrophil degranulation", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "289950": ["Regulation of pyruvate dehydrogenase (PDH) complex", "Glyoxylate metabolism and glycine degradation", "Signaling by Retinoic Acid", "Pyruvate metabolism"], "289990": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "289992": ["Cell-extracellular matrix interactions"], "289994": ["COPII-mediated vesicle transport", "Cargo concentration in the ER"], "290001": ["Olfactory Signaling Pathway"], "290002": ["Olfactory Signaling Pathway"], "290003": ["Olfactory Signaling Pathway"], "290005": ["Olfactory Signaling Pathway"], "290006": ["Olfactory Signaling Pathway"], "290009": ["Olfactory Signaling Pathway"], "290010": ["Olfactory Signaling Pathway"], "290020": ["Olfactory Signaling Pathway"], "290027": ["POLB-Dependent Long Patch Base Excision Repair", "HDR through MMEJ (alt-NHEJ)", "DNA Damage Recognition in GG-NER", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER"], "290029": ["Neutrophil degranulation", "Purine catabolism"], "290046": ["SUMOylation of RNA binding proteins", "mRNA Splicing - Major Pathway"], "290049": ["Olfactory Signaling Pathway"], "290050": ["Olfactory Signaling Pathway"], "290055": ["Olfactory Signaling Pathway"], "290056": ["Olfactory Signaling Pathway"], "290206": ["UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "290223": ["Lipid particle organization"], "290232": ["DNA Damage/Telomere Stress Induced Senescence"], "290257": ["Degradation of the extracellular matrix", "Activation of Matrix Metalloproteinases", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Neutrophil degranulation", "Antimicrobial peptides"], "290277": ["Formation of xylulose-5-phosphate"], "290291": ["Energy dependent regulation of mTOR by LKB1-AMPK"], "290317": ["Deactivation of the beta-catenin transactivating complex"], "290322": ["RNA polymerase II transcribes snRNA genes"], "290361": ["Tie2 Signaling", "RET signaling"], "290365": ["Phosphate bond hydrolysis by NUDT proteins"], "290396": ["RHO GTPases Activate Formins"], "290401": ["Glutathione conjugation"], "290408": ["The NLRP3 inflammasome"], "290409": ["Neutrophil degranulation"], "290467": ["Receptor-type tyrosine-protein phosphatases"], "290493": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (i) signalling events"], "290519": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA 3'-end processing"], "290541": ["NRAGE signals death through JNK", "Rho GTPase cycle"], "290551": ["Choline catabolism"], "290556": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "290561": ["Striated Muscle Contraction"], "290567": ["Synthesis of PC", "Acetylcholine Neurotransmitter Release Cycle"], "290577": ["Separation of Sister Chromatids", "Establishment of Sister Chromatid Cohesion", "Cohesin Loading onto Chromatin", "Resolution of Sister Chromatid Cohesion"], "290614": ["mRNA Splicing - Major Pathway"], "290626": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "290627": ["COPI-dependent Golgi-to-ER retrograde traffic"], "290631": ["Metalloprotease DUBs", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "G2/M DNA damage checkpoint"], "290632": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "290635": ["Endosomal Sorting Complex Required For Transport (ESCRT)"], "290636": ["Pentose phosphate pathway"], "290637": ["Collagen biosynthesis and modifying enzymes"], "290638": ["Keratan sulfate biosynthesis", "O-linked glycosylation of mucins"], "290639": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "290644": ["MHC class II antigen presentation"], "290646": ["DARPP-32 events", "G alpha (s) signalling events"], "290647": ["mRNA decay by 5' to 3' exoribonuclease", "mRNA Splicing - Major Pathway"], "290651": ["Synthesis of IP2, IP, and Ins in the cytosol"], "290652": ["Ub-specific processing proteases"], "290655": ["IL-6-type cytokine receptor ligand interactions", "Interleukin-27 signaling"], "290659": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "290666": ["mRNA Splicing - Major Pathway"], "290668": ["Cohesin Loading onto Chromatin"], "290673": ["Ion transport by P-type ATPases"], "290681": ["Acetylation"], "290741": ["Interconversion of nucleotide di- and triphosphates"], "290744": ["SUMOylation of transcription cofactors", "PI5P Regulates TP53 Acetylation"], "290746": ["RAB GEFs exchange GTP for GDP on RABs"], "290757": ["Intrinsic Pathway of Fibrin Clot Formation"], "290775": ["Endosomal Sorting Complex Required For Transport (ESCRT)"], "290783": ["Miscellaneous transport and binding events"], "290794": ["TCF dependent signaling in response to WNT", "Degradation of AXIN", "Ub-specific processing proteases", "Regulation of PTEN stability and activity"], "290798": ["MHC class II antigen presentation", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic"], "290805": ["HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange"], "290823": ["ABC-family proteins mediated transport"], "290829": ["Formation of the beta-catenin:TCF transactivating complex", "PKMTs methylate histone lysines", "Deactivation of the beta-catenin transactivating complex", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"], "290831": ["PKMTs methylate histone lysines"], "290843": ["Synthesis of PA"], "290850": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "290851": ["Endosomal Sorting Complex Required For Transport (ESCRT)"], "290864": ["TNFR1-induced proapoptotic signaling", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "Ub-specific processing proteases"], "290875": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6", "Antigen processing: Ubiquitination & Proteasome degradation"], "290905": ["Collagen degradation", "Extracellular matrix organization", "Collagen biosynthesis and modifying enzymes", "Signaling by PDGF", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "Anchoring fibril formation", "Crosslinking of collagen fibrils", "Laminin interactions", "Non-integrin membrane-ECM interactions", "NCAM1 interactions"], "290907": ["Nonhomologous End-Joining (NHEJ)"], "290921": ["Signaling by BMP"], "290923": ["Neutrophil degranulation"], "290925": ["RMTs methylate histone arginines"], "290947": ["Methylation", "Sulfur amino acid metabolism", "Cobalamin (Cbl, vitamin B12) transport and metabolism"], "290959": ["Transport of nucleotide sugars"], "290963": ["Metabolism of Angiotensinogen to Angiotensins"], "290970": ["Collagen degradation", "Degradation of the extracellular matrix", "Trafficking and processing of endosomal TLR", "Assembly of collagen fibrils and other multimeric structures", "MHC class II antigen presentation", "RUNX1 regulates transcription of genes involved in differentiation of keratinocytes"], "290975": ["Collagen degradation", "Degradation of the extracellular matrix", "Trafficking and processing of endosomal TLR", "Assembly of collagen fibrils and other multimeric structures", "MHC class II antigen presentation", "RUNX1 regulates transcription of genes involved in differentiation of keratinocytes"], "290981": ["Collagen degradation", "Degradation of the extracellular matrix", "Trafficking and processing of endosomal TLR", "Assembly of collagen fibrils and other multimeric structures", "MHC class II antigen presentation", "RUNX1 regulates transcription of genes involved in differentiation of keratinocytes"], "290989": ["Sperm Motility And Taxes"], "290994": ["COPII-mediated vesicle transport", "Cargo concentration in the ER"], "290995": ["TP53 Regulates Transcription of Genes Involved in Cytochrome C Release"], "290997": ["Metalloprotease DUBs", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "G2/M DNA damage checkpoint"], "291000": ["Neutrophil degranulation"], "291015": ["Keratan sulfate biosynthesis", "Keratan sulfate degradation"], "291060": ["mRNA Splicing - Minor Pathway"], "291061": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "291071": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "291075": ["Beta-oxidation of very long chain fatty acids", "Peroxisomal protein import"], "291081": ["Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Recruitment of NuMA to mitotic centrosomes", "Recycling pathway of L1", "Hedgehog 'off' state", "Cilium Assembly", "Intraflagellar transport", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "Carboxyterminal post-translational modifications of tubulin", "Kinesins"], "291084": ["Phase I - Functionalization of compounds"], "291085": ["Neutrophil degranulation", "Dissolution of Fibrin Clot"], "291091": ["Neutrophil degranulation"], "291095": ["GDP-fucose biosynthesis"], "291105": ["CDC6 association with the ORC:origin complex", "G2 Phase", "Cyclin D associated events in G1"], "291132": ["Post-translational modification: synthesis of GPI-anchored proteins"], "291133": ["Degradation of GABA"], "291135": ["Mitochondrial Fatty Acid Beta-Oxidation"], "291137": ["CDT1 association with the CDC6:ORC:origin complex", "Activation of the pre-replicative complex"], "291152": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "SUMOylation of chromatin organization proteins", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "291159": ["Interleukin-7 signaling", "PRC2 methylates histones and DNA", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "Chromatin modifying enzymes", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression", "Factors involved in megakaryocyte development and platelet production"], "291171": ["SUMOylation of ubiquitinylation proteins", "Regulation of PTEN stability and activity"], "291182": ["Pregnenolone biosynthesis"], "291206": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "291209": ["Degradation of DVL"], "291211": ["Cholesterol biosynthesis"], "291212": ["O-linked glycosylation"], "291245": ["Platelet degranulation ", "Striated Muscle Contraction", "Unblocking of NMDA receptors, glutamate binding and activation", "RAF/MAP kinase cascade"], "291283": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "RA biosynthesis pathway", "Retinoid metabolism and transport"], "291287": ["Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Recruitment of NuMA to mitotic centrosomes", "Recycling pathway of L1", "Cilium Assembly", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "Carboxyterminal post-translational modifications of tubulin", "Kinesins"], "291295": ["mRNA Splicing - Major Pathway"], "291309": ["Retrograde transport at the Trans-Golgi-Network"], "291317": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "29132": ["Ion homeostasis", "Ion transport by P-type ATPases"], "291327": ["Cross-presentation of soluble exogenous antigens (endosomes)"], "291339": ["Neutrophil degranulation", "Neddylation"], "291361": ["Olfactory Signaling Pathway"], "29139": ["Degradation of the extracellular matrix", "A tetrasaccharide linker sequence is required for GAG synthesis", "Chondroitin sulfate biosynthesis", "Dermatan sulfate biosynthesis", "CS/DS degradation", "ECM proteoglycans"], "291394": ["Glutathione synthesis and recycling"], "29141": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "291411": ["Ion transport by P-type ATPases"], "291414": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "RNA Polymerase II Transcription Elongation"], "29142": ["Post-translational modification: synthesis of GPI-anchored proteins", "Vitamin B5 (pantothenate) metabolism", "Neutrophil degranulation"], "29143": ["Neutrophil degranulation"], "291437": ["HDL remodeling"], "291439": ["SUMOylation of transcription cofactors"], "29144": ["MHC class II antigen presentation", "Interleukin-35 Signalling", "Calnexin/calreticulin cycle", "Interleukin-27 signaling", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "291441": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "291450": ["Choline catabolism", "Lysine catabolism"], "291464": ["Golgi Associated Vesicle Biogenesis"], "291470": ["Iron uptake and transport"], "29148": ["CDO in myogenesis"], "29151": ["Class B/2 (Secretin family receptors)"], "291526": ["Translesion synthesis by POLI", "Termination of translesion DNA synthesis"], "291527": ["Pregnenolone biosynthesis"], "29153": ["Degradation of the extracellular matrix", "Neutrophil degranulation"], "291534": ["mRNA Capping", "RNA Pol II CTD phosphorylation and interaction with CE"], "29154": ["Degradation of the extracellular matrix"], "291540": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "29155": ["Degradation of the extracellular matrix"], "291555": ["Ion transport by P-type ATPases"], "291577": ["Chondroitin sulfate biosynthesis"], "29158": ["Elastic fibre formation", "Molecules associated with elastic fibres"], "291582": ["Transport of fatty acids"], "291585": ["Pyrimidine salvage"], "291597": ["Antigen processing: Ubiquitination & Proteasome degradation"], "29160": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "291604": ["mRNA decay by 5' to 3' exoribonuclease", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "KSRP (KHSRP) binds and destabilizes mRNA"], "29161": ["Smooth Muscle Contraction"], "291615": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Deadenylation of mRNA", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Translation initiation complex formation", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "29162": ["Adherens junctions interactions"], "29163": ["Adherens junctions interactions"], "291640": ["Urea cycle"], "291660": ["Respiratory electron transport", "Complex I biogenesis"], "291671": ["Regulation of HSF1-mediated heat shock response"], "291678": ["WNT ligand biogenesis and trafficking", "Disassembly of the destruction complex and recruitment of AXIN to the membrane"], "29168": ["Neddylation"], "291689": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6", "Antigen processing: Ubiquitination & Proteasome degradation"], "29169": ["Molecules associated with elastic fibres", "Integrin cell surface interactions", "Syndecan interactions", "ECM proteoglycans", "Regulation of Complement cascade"], "291694": ["Rho GTPase cycle"], "291699": ["Pregnenolone biosynthesis"], "291703": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "mRNA Capping", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase I Transcription Termination", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE"], "291705": ["Formation of RNA Pol II elongation complex ", "RNA Polymerase II Pre-transcription Events", "RNA Polymerase II Transcription Elongation"], "29171": ["Transport of glycerol from adipocytes to the liver by Aquaporins", "Passive transport by Aquaporins"], "29172": ["Passive transport by Aquaporins"], "291733": ["Zinc influx into cells by the SLC39 gene family"], "291736": ["RNA polymerase II transcribes snRNA genes"], "291737": ["UCH proteinases", "DNA Damage Recognition in GG-NER"], "29174": ["Collagen degradation", "Degradation of the extracellular matrix", "Trafficking and processing of endosomal TLR", "Assembly of collagen fibrils and other multimeric structures", "MHC class II antigen presentation", "RUNX1 regulates transcription of genes involved in differentiation of keratinocytes"], "29175": ["Collagen degradation", "Activation of Matrix Metalloproteinases", "Trafficking and processing of endosomal TLR", "MHC class II antigen presentation", "RUNX1 regulates transcription of genes involved in differentiation of keratinocytes"], "291750": ["RAB GEFs exchange GTP for GDP on RABs"], "291752": ["Apoptotic cleavage of cell adhesion  proteins", "Keratinization", "Formation of the cornified envelope"], "291754": ["Keratinization", "Formation of the cornified envelope"], "291760": ["Keratinization", "Formation of the cornified envelope"], "291770": ["Chondroitin sulfate biosynthesis"], "291772": ["Negative regulation of activity of TFAP2 (AP-2) family transcription factors"], "291787": ["HDR through Single Strand Annealing (SSA)", "HDR through MMEJ (alt-NHEJ)", "HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange"], "291793": ["Synthesis of PC"], "291794": ["snRNP Assembly", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "291796": ["Ub-specific processing proteases"], "291797": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA 3'-end processing"], "29180": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "29181": ["Adherens junctions interactions"], "291819": ["Reversible hydration of carbon dioxide"], "291824": ["Pyrimidine salvage"], "29183": ["PIP3 activates AKT signaling", "Signaling by EGFR", "GRB2 events in EGFR signaling", "GAB1 signalosome", "SHC1 events in EGFR signaling", "EGFR downregulation", "COPII-mediated vesicle transport", "EGFR interacts with phospholipase C-gamma", "RAF/MAP kinase cascade", "Cargo concentration in the ER", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "29184": ["Platelet degranulation ", "Scavenging by Class B Receptors", "Regulation of TLR by endogenous ligand", "Neutrophil degranulation"], "291841": ["Deadenylation of mRNA", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "291844": ["PKMTs methylate histone lysines"], "291848": ["Collagen degradation", "Degradation of the extracellular matrix", "Activation of Matrix Metalloproteinases"], "291854": ["Neutrophil degranulation"], "29186": ["Platelet degranulation ", "Neutrophil degranulation"], "291874": ["Transport of Mature mRNA derived from an Intron-Containing Transcript", "SUMOylation of DNA damage response and repair proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of DNA replication proteins"], "291877": ["Cleavage of Growing Transcript in the Termination Region ", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "291885": ["Activation of ATR in response to replication stress", "Assembly of the pre-replicative complex", "Orc1 removal from chromatin", "Activation of the pre-replicative complex", "Switching of origins to a post-replicative state"], "29190": ["Opioid Signalling", "G-protein activation", "Peptide ligand-binding receptors", "G alpha (i) signalling events"], "291905": ["Reversal of alkylation damage by DNA dioxygenases"], "291912": ["NOD1/2 Signaling Pathway", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "Ovarian tumor domain proteases", "Interleukin-1 signaling"], "291914": ["Depolymerisation of the Nuclear Lamina"], "29192": ["Regulated proteolysis of p75NTR", "NRIF signals cell death from the nucleus", "Neutrophil degranulation", "NOTCH3 Activation and Transmission of Signal to the Nucleus"], "291922": ["Peroxisomal protein import"], "291927": ["Activation of ATR in response to replication stress", "Assembly of the ORC complex at the origin of replication", "CDC6 association with the ORC:origin complex", "CDT1 association with the CDC6:ORC:origin complex", "Assembly of the pre-replicative complex", "Orc1 removal from chromatin", "Activation of the pre-replicative complex"], "291936": ["Ligand-receptor interactions"], "291939": ["Cobalamin (Cbl, vitamin B12) transport and metabolism", "Propionyl-CoA catabolism"], "29194": ["Synthesis of PC", "Synthesis of PE"], "291948": ["Neutrophil degranulation"], "291952": ["Phase I - Functionalization of compounds"], "291958": ["O-linked glycosylation of mucins"], "291969": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "291983": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "291984": ["Synthesis of Leukotrienes (LT) and Eoxins (EX)"], "291987": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "29199": ["Transferrin endocytosis and recycling"], "291990": ["COPI-mediated anterograde transport", "Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network"], "291996": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "29200": ["Signaling by Activin", "Glycoprotein hormones", "Antagonism of Activin by Follistatin"], "292007": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing"], "29201": ["IL-6-type cytokine receptor ligand interactions"], "292019": ["mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "29204": ["Glycosphingolipid metabolism"], "29205": ["Neutrophil degranulation"], "292058": ["Unwinding of DNA"], "292064": ["Regulation of TP53 Activity through Association with Co-factors"], "292071": ["CDT1 association with the CDC6:ORC:origin complex", "Assembly of the pre-replicative complex", "Orc1 removal from chromatin", "Activation of the pre-replicative complex"], "292072": ["Neutrophil degranulation", "Purine salvage"], "292073": ["Keratan sulfate degradation", "Neutrophil degranulation"], "292074": ["COPII-mediated vesicle transport", "RAB GEFs exchange GTP for GDP on RABs"], "292085": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA damage response and repair proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of DNA replication proteins", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "292090": ["COPI-independent Golgi-to-ER retrograde traffic", "O-linked glycosylation of mucins"], "292097": ["Cholesterol biosynthesis"], "29210": ["EPH-Ephrin signaling", "EPHA-mediated growth cone collapse", "EPH-ephrin mediated repulsion of cells"], "292101": ["Translesion Synthesis by POLH"], "29211": ["MHC class II antigen presentation", "NCAM signaling for neurite out-growth", "Interaction between L1 and Ankyrins", "RAF/MAP kinase cascade", "COPI-mediated anterograde transport"], "292124": ["Post-translational modification: synthesis of GPI-anchored proteins"], "292127": ["Fanconi Anemia Pathway"], "29213": ["Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Regulation of PLK1 Activity at G2/M Transition", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Recycling pathway of L1", "Hedgehog 'off' state", "Cilium Assembly", "Anchoring of the basal body to the plasma membrane", "Intraflagellar transport", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "AURKA Activation by TPX2", "Carboxyterminal post-translational modifications of tubulin", "Kinesins"], "29214": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "Neutrophil degranulation", "AURKA Activation by TPX2"], "292148": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "292155": ["HS-GAG biosynthesis"], "292168": ["TRP channels"], "29220": ["Signaling by PDGF"], "29221": ["Neutrophil degranulation", "Urea cycle"], "29223": ["Interconversion of nucleotide di- and triphosphates"], "292244": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "292263": ["SCF-beta-TrCP mediated degradation of Emi1", "Regulation of APC/C activators between G1/S and early anaphase", "Phosphorylation of Emi1", "Mitotic Metaphase/Anaphase Transition"], "292279": ["RHO GTPases Activate NADPH Oxidases"], "292295": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Deadenylation of mRNA", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Translation initiation complex formation", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "29230": ["Cholesterol biosynthesis"], "292306": ["Neutrophil degranulation"], "292310": ["G alpha (i) signalling events", "Free fatty acid receptors"], "292311": ["Carboxyterminal post-translational modifications of tubulin"], "29232": ["Stimuli-sensing channels"], "292325": ["O-linked glycosylation of mucins"], "29233": ["Stimuli-sensing channels"], "29234": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "29235": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "29237": ["Peptide ligand-binding receptors", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "G alpha (i) signalling events", "Post-translational protein phosphorylation"], "29238": ["Dopamine receptors", "G alpha (i) signalling events"], "29240": ["POLB-Dependent Long Patch Base Excision Repair", "Resolution of AP sites via the multiple-nucleotide patch replacement pathway", "Resolution of AP sites via the single-nucleotide replacement pathway", "APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "PCNA-Dependent Long Patch Base Excision Repair", "Ub-specific processing proteases", "Abasic sugar-phosphate removal via the single-nucleotide replacement pathway"], "292406": ["Signaling by PDGF", "O-glycosylation of TSR domain-containing proteins"], "292409": ["G alpha (i) signalling events", "Formyl peptide receptors bind formyl peptides and many other ligands", "Neutrophil degranulation"], "292413": ["G alpha (i) signalling events", "Formyl peptide receptors bind formyl peptides and many other ligands"], "292419": ["G alpha (i) signalling events", "Formyl peptide receptors bind formyl peptides and many other ligands"], "29244": ["Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation"], "29248": ["Striated Muscle Contraction", "Ion homeostasis"], "292485": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Neutrophil degranulation", "Post-translational protein phosphorylation"], "29251": ["Intrinsic Pathway of Fibrin Clot Formation", "Common Pathway of Fibrin Clot Formation", "Gamma-carboxylation of protein precursors", "Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "Removal of aminoterminal propeptides from gamma-carboxylated proteins", "Cell surface interactions at the vascular wall", "Peptide ligand-binding receptors", "G alpha (q) signalling events", "Thrombin signalling through proteinase activated receptors (PARs)", "Platelet Aggregation (Plug Formation)", "Regulation of Complement cascade"], "29252": ["Alternative complement activation"], "29253": ["Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB", "Metabolism of serotonin"], "292536": ["mRNA Splicing - Major Pathway"], "292537": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation"], "29254": ["Acyl chain remodeling of DAG and TAG", "Arachidonate production from DAG"], "292545": ["Regulation of innate immune responses to cytosolic DNA", "IRF3-mediated induction of type I IFN"], "292548": ["Generic Transcription Pathway"], "29256": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "29258": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "292588": ["Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Antigen processing: Ubiquitination & Proteasome degradation"], "292597": ["Stimuli-sensing channels"], "29261": ["Interconversion of nucleotide di- and triphosphates"], "292610": ["Generic Transcription Pathway"], "292640": ["Endosomal Sorting Complex Required For Transport (ESCRT)"], "292657": ["Amino acid transport across the plasma membrane"], "292658": ["Sphingolipid de novo biosynthesis"], "292661": ["Prostanoid ligand receptors", "Prostacyclin signalling through prostacyclin receptor", "G alpha (s) signalling events"], "292671": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "292673": ["HDR through Single Strand Annealing (SSA)", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Fanconi Anemia Pathway"], "292683": ["Cleavage of Growing Transcript in the Termination Region ", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "292697": ["Chylomicron assembly", "Chylomicron remodeling", "HDL remodeling", "Retinoid metabolism and transport"], "29270": ["Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation"], "292710": ["Sulfide oxidation to sulfate"], "292721": ["Oncogene Induced Senescence"], "292729": ["mRNA Splicing - Major Pathway"], "292734": ["Molecules associated with elastic fibres"], "292737": ["Heme degradation"], "29274": ["Antigen processing: Ubiquitination & Proteasome degradation"], "292747": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "29275": ["Striated Muscle Contraction"], "292750": ["NRAGE signals death through JNK", "Rho GTPase cycle"], "292757": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "292758": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "292762": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "292766": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "292767": ["Sperm Motility And Taxes"], "29277": ["Xenobiotics"], "292770": ["MET Receptor Activation"], "292778": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Transcriptional regulation by small RNAs", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE", "Estrogen-dependent gene expression"], "292787": ["G0 and Early G1"], "292788": ["Regulated proteolysis of p75NTR", "NRIF signals cell death from the nucleus", "NOTCH3 Activation and Transmission of Signal to the Nucleus"], "292794": ["G alpha (q) signalling events", "Free fatty acid receptors"], "292804": ["Neutrophil degranulation", "Glycolysis"], "292811": ["Anchoring of the basal body to the plasma membrane"], "29282": ["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "29283": ["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "292844": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "292845": ["Respiratory electron transport", "Protein methylation"], "292848": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Formation of the cornified envelope"], "29285": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "292852": ["Degradation of the extracellular matrix"], "292855": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "292858": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "292866": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "292868": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "292876": ["Josephin domain DUBs"], "292879": ["Striated Muscle Contraction"], "29288": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "292884": ["Cleavage of Growing Transcript in the Termination Region ", "SLBP independent Processing of Histone Pre-mRNAs", "Generic Transcription Pathway", "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"], "292886": ["TBC/RABGAPs"], "292887": ["mTOR signalling", "mTORC1-mediated signalling", "AKT phosphorylates targets in the cytosol", "HSF1-dependent transactivation"], "292892": ["ISG15 antiviral mechanism", "IRF3 mediated activation of type 1 IFN", "LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "Regulation of innate immune responses to cytosolic DNA", "IRF3-mediated induction of type I IFN", "TICAM1-dependent activation of IRF3/IRF7", "TRAF3-dependent IRF activation pathway", "TRAF6 mediated IRF7 activation", "Negative regulators of DDX58/IFIH1 signaling", "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon"], "292894": ["NOSIP mediated eNOS trafficking"], "29290": ["Adenosine P1 receptors", "G alpha (i) signalling events"], "292915": ["Cytosolic sulfonation of small molecules"], "29292": ["Golgi Associated Vesicle Biogenesis", "Neutrophil degranulation", "Iron uptake and transport"], "292925": ["Endosomal Sorting Complex Required For Transport (ESCRT)"], "292949": ["Formation of the cornified envelope"], "292964": ["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "292999": ["Chondroitin sulfate biosynthesis"], "29301": ["Histidine catabolism"], "293023": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "293024": ["NRAGE signals death through JNK", "Rho GTPase cycle"], "293044": ["Generic Transcription Pathway"], "293047": ["Hedgehog 'off' state", "Hedgehog 'on' state"], "293049": ["The retinoid cycle in cones (daylight vision)", "The canonical retinoid cycle in rods (twilight vision)"], "293054": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "293060": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "293067": ["Peroxisomal protein import"], "293075": ["Olfactory Signaling Pathway"], "293083": ["Olfactory Signaling Pathway"], "293085": ["Olfactory Signaling Pathway"], "29309": ["Ubiquinol biosynthesis"], "293091": ["Olfactory Signaling Pathway"], "29310": ["Peptide ligand-binding receptors", "G alpha (s) signalling events"], "293103": ["Regulation of HSF1-mediated heat shock response"], "293104": ["PRC2 methylates histones and DNA", "Oxidative Stress Induced Senescence", "PKMTs methylate histone lysines", "Regulation of PTEN gene transcription", "Transcriptional Regulation by E2F6"], "293114": ["Complex I biogenesis"], "293118": ["Intrinsic Pathway of Fibrin Clot Formation", "Neutrophil degranulation"], "293130": ["Respiratory electron transport", "Neutrophil degranulation", "Complex I biogenesis"], "293142": ["Synthesis, secretion, and deacylation of Ghrelin"], "293148": ["Anchoring of the basal body to the plasma membrane"], "293149": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "293150": ["Synthesis of PC"], "293154": ["Post-translational modification: synthesis of GPI-anchored proteins", "Metabolism of folate and pterines"], "293155": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6"], "293165": ["Deactivation of the beta-catenin transactivating complex"], "293173": ["Wax biosynthesis"], "293181": ["O-linked glycosylation of mucins"], "293184": ["Formation of RNA Pol II elongation complex ", "RNA Polymerase II Pre-transcription Events", "RNA Polymerase II Transcription Elongation", "E3 ubiquitin ligases ubiquitinate target proteins"], "293186": ["Hyaluronan uptake and degradation"], "29319": ["Cobalamin (Cbl, vitamin B12) transport and metabolism"], "293210": ["Olfactory Signaling Pathway"], "293211": ["Olfactory Signaling Pathway"], "293214": ["Olfactory Signaling Pathway"], "293215": ["Olfactory Signaling Pathway"], "293218": ["Olfactory Signaling Pathway"], "29322": ["PLC beta mediated events", "Synthesis of IP3 and IP4 in the cytosol", "Acetylcholine regulates insulin secretion", "Ca2+ pathway", "G alpha (q) signalling events", "G beta:gamma signalling through PLC beta", "Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "Presynaptic function of Kainate receptors"], "293221": ["Olfactory Signaling Pathway"], "293224": ["Olfactory Signaling Pathway"], "293226": ["Olfactory Signaling Pathway"], "29324": ["MHC class II antigen presentation", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic"], "293251": ["Olfactory Signaling Pathway"], "293255": ["Olfactory Signaling Pathway"], "293256": ["Olfactory Signaling Pathway"], "293262": ["Olfactory Signaling Pathway"], "293268": ["Olfactory Signaling Pathway"], "293271": ["Olfactory Signaling Pathway"], "293278": ["Olfactory Signaling Pathway"], "293279": ["Olfactory Signaling Pathway"], "29328": ["Synthesis of 12-eicosatetraenoic acid derivatives", "Synthesis of 15-eicosatetraenoic acid derivatives", "Biosynthesis of E-series 18(S)-resolvins"], "293281": ["Olfactory Signaling Pathway"], "293285": ["Olfactory Signaling Pathway"], "293289": ["Olfactory Signaling Pathway"], "29331": ["ECM proteoglycans"], "293316": ["Olfactory Signaling Pathway"], "293319": ["Olfactory Signaling Pathway"], "293321": ["Olfactory Signaling Pathway"], "293327": ["Olfactory Signaling Pathway"], "293329": ["Olfactory Signaling Pathway"], "29333": ["Regulation of Complement cascade"], "293333": ["Olfactory Signaling Pathway"], "293334": ["Olfactory Signaling Pathway"], "293338": ["Olfactory Signaling Pathway"], "293340": ["Olfactory Signaling Pathway"], "293344": ["Retrograde transport at the Trans-Golgi-Network"], "293345": ["Ub-specific processing proteases", "RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "29335": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "293350": ["Olfactory Signaling Pathway"], "293351": ["Olfactory Signaling Pathway"], "293353": ["Olfactory Signaling Pathway"], "293355": ["Olfactory Signaling Pathway"], "293357": ["Olfactory Signaling Pathway"], "293361": ["Olfactory Signaling Pathway"], "293362": ["Olfactory Signaling Pathway"], "293364": ["Olfactory Signaling Pathway"], "293370": ["Olfactory Signaling Pathway"], "293373": ["Olfactory Signaling Pathway"], "293374": ["Olfactory Signaling Pathway"], "293375": ["Olfactory Signaling Pathway"], "293377": ["Olfactory Signaling Pathway"], "293379": ["Olfactory Signaling Pathway"], "29338": ["Detoxification of Reactive Oxygen Species", "TP53 Regulates Metabolic Genes"], "293382": ["Olfactory Signaling Pathway"], "293389": ["Olfactory Signaling Pathway"], "293392": ["Olfactory Signaling Pathway"], "293394": ["Olfactory Signaling Pathway"], "293398": ["Olfactory Signaling Pathway"], "293399": ["Olfactory Signaling Pathway"], "293400": ["Olfactory Signaling Pathway"], "293402": ["Olfactory Signaling Pathway"], "293408": ["mRNA decay by 3' to 5' exoribonuclease"], "293421": ["Olfactory Signaling Pathway"], "293424": ["Olfactory Signaling Pathway"], "293425": ["Olfactory Signaling Pathway"], "293427": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "293431": ["Olfactory Signaling Pathway"], "293435": ["Olfactory Signaling Pathway"], "293437": ["Olfactory Signaling Pathway"], "293439": ["Olfactory Signaling Pathway"], "29344": ["Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA"], "293451": ["HS-GAG biosynthesis"], "293452": ["HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange"], "293453": ["Glyoxylate metabolism and glycine degradation", "Respiratory electron transport", "Complex I biogenesis", "Mitochondrial Fatty Acid Beta-Oxidation"], "293456": ["COPI-mediated anterograde transport", "Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network"], "29347": ["Arachidonic acid metabolism"], "29348": ["PI3K Cascade", "PIP3 activates AKT signaling", "FGFR2b ligand binding and activation", "Phospholipase C-mediated cascade; FGFR2", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "Negative regulation of FGFR2 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "293484": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "293489": ["Resolution of D-loop Structures through Holliday Junction Intermediates", "Fanconi Anemia Pathway"], "29349": ["PI3K Cascade", "PIP3 activates AKT signaling", "FGFR4 ligand binding and activation", "FGFR3b ligand binding and activation", "FGFR3c ligand binding and activation", "FGFR1c ligand binding and activation", "FGFR2c ligand binding and activation", "Phospholipase C-mediated cascade: FGFR1", "Phospholipase C-mediated cascade; FGFR2", "Phospholipase C-mediated cascade; FGFR3", "Phospholipase C-mediated cascade; FGFR4", "Downstream signaling of activated FGFR1", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "PI-3K cascade:FGFR3", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "PI-3K cascade:FGFR4", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "FGFRL1 modulation of FGFR1 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "293494": ["UCH proteinases", "DNA Damage Recognition in GG-NER"], "293502": ["MHC class II antigen presentation", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "293504": ["Nicotinate metabolism"], "293505": ["mRNA Splicing - Major Pathway"], "293508": ["PKA activation", "PKA activation in glucagon signalling", "DARPP-32 events", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Rap1 signalling", "Regulation of insulin secretion", "Vasopressin regulates renal water homeostasis via Aquaporins", "VEGFA-VEGFR2 Pathway", "CREB1 phosphorylation through the activation of Adenylate Cyclase", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'off' state", "CD209 (DC-SIGN) signaling", "MAPK6/MAPK4 signaling", "HDL assembly", "Factors involved in megakaryocyte development and platelet production"], "293524": ["Regulation of HSF1-mediated heat shock response"], "29353": ["Glycogen breakdown (glycogenolysis)"], "29354": ["Acyl chain remodelling of PS", "Acyl chain remodelling of PG"], "29355": ["RHO GTPases activate PKNs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3"], "293561": ["E3 ubiquitin ligases ubiquitinate target proteins"], "29357": ["Signaling by NODAL", "Signaling by Activin", "Downregulation of TGF-beta receptor signaling", "TGF-beta receptor signaling activates SMADs", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Ub-specific processing proteases", "FOXO-mediated transcription of cell cycle genes"], "29358": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "293587": ["GDP-fucose biosynthesis"], "293589": ["PAOs oxidise polyamines to amines", "Interconversion of polyamines", "Peroxisomal protein import"], "293618": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "293619": ["Keratinization", "Formation of the cornified envelope"], "293620": ["Synthesis of PS"], "293621": ["Activation of RAS in B cells", "SHC1 events in ERBB4 signaling", "Signaling by SCF-KIT", "p38MAPK events", "GRB2 events in EGFR signaling", "SHC1 events in EGFR signaling", "Downstream signal transduction", "GRB2 events in ERBB2 signaling", "Tie2 Signaling", "EGFR Transactivation by Gastrin", "DAP12 signaling", "FCERI mediated MAPK activation", "NCAM signaling for neurite out-growth", "EPHB-mediated forward signaling", "VEGFR2 mediated cell proliferation", "CD209 (DC-SIGN) signaling", "SHC-mediated cascade:FGFR1", "FRS-mediated FGFR1 signaling", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "Regulation of RAS by GAPs", "RAF activation", "RAF/MAP kinase cascade", "MAP2K and MAPK activation", "Negative regulation of MAPK pathway", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "MET activates RAS signaling"], "293625": ["TP53 Regulates Transcription of Caspase Activators and Caspases"], "293628": ["Platelet degranulation "], "29363": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "29364": ["Cell surface interactions at the vascular wall", "Integrin cell surface interactions", "Signal regulatory protein family interactions", "Neutrophil degranulation"], "293645": ["Serotonin Neurotransmitter Release Cycle", "Norepinephrine Neurotransmitter Release Cycle", "Glutamate Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle", "Acetylcholine Neurotransmitter Release Cycle", "Receptor-type tyrosine-protein phosphatases"], "293650": ["ROS, RNS production in phagocytes", "Neutrophil degranulation", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "293652": ["Respiratory electron transport", "Complex I biogenesis"], "293653": ["Aflatoxin activation and detoxification"], "293655": ["Respiratory electron transport", "Complex I biogenesis"], "29366": ["Intrinsic Pathway of Fibrin Clot Formation", "Common Pathway of Fibrin Clot Formation", "Dissolution of Fibrin Clot"], "293660": ["Rho GTPase cycle", "RHO GTPases Activate Formins"], "293666": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "293667": ["Keratan sulfate biosynthesis", "O-linked glycosylation"], "293674": ["Signaling by NODAL", "Signaling by Activin"], "293676": ["Platelet degranulation "], "293677": ["Molecules associated with elastic fibres"], "293678": ["Resolution of D-loop Structures through Holliday Junction Intermediates", "Fanconi Anemia Pathway"], "29368": ["PI3K Cascade", "PIP3 activates AKT signaling", "FGFR4 ligand binding and activation", "FGFR3b ligand binding and activation", "FGFR3c ligand binding and activation", "FGFR1c ligand binding and activation", "FGFR2c ligand binding and activation", "Phospholipase C-mediated cascade: FGFR1", "Phospholipase C-mediated cascade; FGFR2", "Phospholipase C-mediated cascade; FGFR3", "Phospholipase C-mediated cascade; FGFR4", "Downstream signaling of activated FGFR1", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "PI-3K cascade:FGFR3", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "PI-3K cascade:FGFR4", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "FGFRL1 modulation of FGFR1 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "293688": ["Cholesterol biosynthesis"], "293692": ["Factors involved in megakaryocyte development and platelet production"], "293700": ["Methylation", "Eukaryotic Translation Termination"], "293701": ["Nuclear Receptor transcription pathway"], "293705": ["Ub-specific processing proteases", "Ovarian tumor domain proteases"], "293711": ["Acyl chain remodelling of PE"], "293719": ["N-glycan trimming in the ER and Calnexin/Calreticulin cycle"], "293722": ["A tetrasaccharide linker sequence is required for GAG synthesis"], "293733": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA replication proteins", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "293735": ["Stimuli-sensing channels"], "29374": ["Association of TriC/CCT with target proteins during biosynthesis", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "293754": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "293759": ["Olfactory Signaling Pathway"], "29376": ["PI3K Cascade", "IRS-mediated signalling", "SOS-mediated signalling", "PIP3 activates AKT signaling", "Interleukin-7 signaling", "PI3K/AKT activation", "IRS-related events triggered by IGF1R", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "IRS activation", "Signal attenuation", "RET signaling", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "Erythropoietin activates RAS"], "293761": ["Olfactory Signaling Pathway"], "293763": ["Olfactory Signaling Pathway"], "293764": ["Olfactory Signaling Pathway"], "293769": ["Olfactory Signaling Pathway"], "293773": ["Olfactory Signaling Pathway"], "293774": ["Activated NOTCH1 Transmits Signal to the Nucleus", "Regulation of innate immune responses to cytosolic DNA", "IRF3-mediated induction of type I IFN"], "293779": ["Conjugation of benzoate with glycine"], "293781": ["Olfactory Signaling Pathway"], "293785": ["Olfactory Signaling Pathway"], "293788": ["Olfactory Signaling Pathway"], "293789": ["Olfactory Signaling Pathway"], "293793": ["Olfactory Signaling Pathway"], "29380": ["Interaction between PHLDA1 and AURKA"], "293805": ["Olfactory Signaling Pathway"], "293808": ["Olfactory Signaling Pathway"], "293809": ["Olfactory Signaling Pathway"], "29381": ["Signaling by Activin"], "293810": ["Olfactory Signaling Pathway"], "293812": ["Olfactory Signaling Pathway"], "293815": ["Olfactory Signaling Pathway"], "293817": ["Olfactory Signaling Pathway"], "29382": ["Deactivation of the beta-catenin transactivating complex", "SUMOylation of transcription cofactors", "Repression of WNT target genes"], "293828": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "293829": ["Propionyl-CoA catabolism"], "293844": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "293847": ["RAF-independent MAPK1/3 activation", "Negative regulation of MAPK pathway"], "29385": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events", "Neutrophil degranulation"], "293852": ["Apoptotic cleavage of cellular proteins", "Apoptotic execution phase", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "29386": ["Regulation of MECP2 expression and activity"], "293860": ["Platelet degranulation ", "GP1b-IX-V activation signalling", "Cell-extracellular matrix interactions", "RHO GTPases activate PAKs"], "293871": ["Histidine catabolism"], "29388": ["Striated Muscle Contraction"], "293886": ["Platelet degranulation "], "29389": ["Striated Muscle Contraction"], "293897": ["Negative regulation of TCF-dependent signaling by WNT ligand antagonists"], "29393": ["GPVI-mediated activation cascade", "Collagen degradation", "Extracellular matrix organization", "Collagen biosynthesis and modifying enzymes", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Assembly of collagen fibrils and other multimeric structures", "Cell surface interactions at the vascular wall", "Integrin cell surface interactions", "Anchoring fibril formation", "Crosslinking of collagen fibrils", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "GP1b-IX-V activation signalling", "Platelet Adhesion to exposed collagen", "Platelet Aggregation (Plug Formation)", "MET activates PTK2 signaling", "Collagen chain trimerization"], "293939": ["ABC-family proteins mediated transport"], "293947": ["Rho GTPase cycle"], "293949": ["Glyoxylate metabolism and glycine degradation"], "29395": ["Activation of DNA fragmentation factor"], "293967": ["SUMOylation of DNA damage response and repair proteins"], "29398": ["Neutrophil degranulation"], "293990": ["WNT ligand biogenesis and trafficking", "Disassembly of the destruction complex and recruitment of AXIN to the membrane"], "293991": ["Mitochondrial protein import", "Respiratory electron transport", "Complex I biogenesis"], "294010": ["MHC class II antigen presentation", "Regulation of PLK1 Activity at G2/M Transition", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic", "AURKA Activation by TPX2"], "294018": ["RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "294027": ["Collagen biosynthesis and modifying enzymes", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Assembly of collagen fibrils and other multimeric structures", "Type I hemidesmosome assembly", "Collagen chain trimerization"], "29403": ["Asparagine N-linked glycosylation"], "294048": ["PIP3 activates AKT signaling", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "294065": ["Voltage gated Potassium channels"], "29407": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "294075": ["Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "G alpha (q) signalling events"], "294088": ["Coenzyme A biosynthesis"], "29409": ["Axonal growth inhibition (RHOA activation)", "Basigin interactions"], "294094": ["Formation of the cornified envelope"], "294097": ["Formation of the cornified envelope"], "294103": ["Transport and synthesis of PAPS"], "29411": ["Fatty acyl-CoA biosynthesis"], "29412": ["Adrenoceptors", "G alpha (q) signalling events", "G alpha (12/13) signalling events"], "294121": ["Amine ligand-binding receptors", "G alpha (s) signalling events"], "294123": ["Amine ligand-binding receptors", "G alpha (s) signalling events"], "294124": ["Amine ligand-binding receptors", "G alpha (s) signalling events"], "294141": ["Stimuli-sensing channels", "Ion homeostasis"], "29415": ["G alpha (i) signalling events", "Lysosphingolipid and LPA receptors"], "29416": ["Lysine catabolism", "Tryptophan catabolism"], "29417": ["Formation of the beta-catenin:TCF transactivating complex", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Deactivation of the beta-catenin transactivating complex", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "RHO GTPases activate IQGAPs", "Post-translational protein phosphorylation"], "294190": ["Olfactory Signaling Pathway"], "294197": ["Olfactory Signaling Pathway"], "294198": ["Olfactory Signaling Pathway"], "294203": ["Olfactory Signaling Pathway"], "294204": ["Olfactory Signaling Pathway"], "29421": ["Heme biosynthesis"], "29422": ["Highly sodium permeable acetylcholine nicotinic receptors"], "294228": ["ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "29423": ["L1CAM interactions"], "294230": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "294232": ["mRNA Splicing - Major Pathway"], "294235": ["PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "294236": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "mRNA Capping", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase I Transcription Termination", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE"], "294239": ["eNOS activation"], "294241": ["Post-translational modification: synthesis of GPI-anchored proteins"], "29425": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "294254": ["Regulation of HSF1-mediated heat shock response", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Attenuation phase", "HSF1-dependent transactivation", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Neutrophil degranulation"], "294255": ["Synthesis of PC", "Transport of bile salts and organic acids, metal ions and amine compounds"], "294257": ["Alternative complement activation", "Activation of C3 and C5", "Regulation of Complement cascade"], "294258": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "RNA Polymerase II Transcription Elongation"], "294260": ["mRNA decay by 3' to 5' exoribonuclease"], "294269": ["Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "MHC class II antigen presentation", "PD-1 signaling"], "294270": ["Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "MHC class II antigen presentation", "PD-1 signaling"], "294273": ["MHC class II antigen presentation"], "294274": ["MHC class II antigen presentation"], "294276": ["RUNX3 regulates p14-ARF"], "294279": ["Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Assembly of collagen fibrils and other multimeric structures", "Non-integrin membrane-ECM interactions", "MET activates PTK2 signaling", "Collagen chain trimerization"], "294281": ["Zinc influx into cells by the SLC39 gene family"], "294282": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "294286": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "294287": ["PRC2 methylates histones and DNA"], "294292": ["Synthesis of pyrophosphates in the cytosol"], "294297": ["Degradation of the extracellular matrix"], "29431": ["Generation of second messenger molecules", "Regulation of actin dynamics for phagocytic cup formation", "FCERI mediated MAPK activation", "DSCAM interactions", "CD28 dependent Vav1 pathway", "EPHB-mediated forward signaling", "Ephrin signaling", "Sema3A PAK dependent Axon repulsion", "Signal transduction by L1", "Smooth Muscle Contraction", "VEGFR2 mediated vascular permeability", "CD209 (DC-SIGN) signaling", "RHO GTPases activate PAKs", "MAPK6/MAPK4 signaling", "G beta:gamma signalling through CDC42"], "29432": ["Generation of second messenger molecules", "FCERI mediated MAPK activation", "CD28 dependent Vav1 pathway", "Ephrin signaling", "Sema3A PAK dependent Axon repulsion", "VEGFA-VEGFR2 Pathway", "Smooth Muscle Contraction", "VEGFR2 mediated vascular permeability", "CD209 (DC-SIGN) signaling", "RHO GTPases activate PAKs", "MAPK6/MAPK4 signaling"], "294320": ["Pyruvate metabolism"], "294321": ["Gluconeogenesis"], "294324": ["Synthesis of PA", "COPI-independent Golgi-to-ER retrograde traffic"], "294329": ["TRP channels", "Neutrophil degranulation"], "29433": ["Generation of second messenger molecules", "CD28 dependent Vav1 pathway", "Ephrin signaling", "Sema3A PAK dependent Axon repulsion", "VEGFR2 mediated vascular permeability", "CD209 (DC-SIGN) signaling", "RHO GTPases activate PAKs", "MAPK6/MAPK4 signaling"], "294331": ["Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Antigen processing: Ubiquitination & Proteasome degradation"], "29434": ["Activation of RAS in B cells", "Integrin alphaIIb beta3 signaling", "Rap1 signalling", "RAF/MAP kinase cascade"], "294341": ["Cellular hexose transport"], "29436": ["Extrinsic Pathway of Fibrin Clot Formation"], "29437": ["Striated Muscle Contraction"], "294380": ["Neurexins and neuroligins"], "294394": ["G alpha (q) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "29440": ["Multifunctional anion exchangers"], "294400": ["Synthesis of Dolichyl-phosphate"], "294408": ["Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "294410": ["Intra-Golgi traffic", "Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2"], "294421": ["Serine biosynthesis"], "294429": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA damage response and repair proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of SUMOylation proteins", "SUMOylation of DNA replication proteins", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "29443": ["Methylation", "Sulfur amino acid metabolism"], "294449": ["HS-GAG biosynthesis"], "29446": ["G alpha (s) signalling events", "Glucagon-type ligand receptors"], "29448": ["MHC class II antigen presentation", "Neutrophil degranulation", "TBC/RABGAPs", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "294504": ["Cytosolic tRNA aminoacylation", "Pyrophosphate hydrolysis"], "294515": ["Signaling by NODAL", "AKT phosphorylates targets in the nucleus", "MAPK6/MAPK4 signaling", "Regulation of localization of FOXO transcription factors", "Regulation of FOXO transcriptional activity by acetylation", "FOXO-mediated transcription of cell cycle genes"], "294518": ["TP53 Regulates Metabolic Genes"], "294520": ["Factors involved in megakaryocyte development and platelet production"], "294521": ["Interconversion of nucleotide di- and triphosphates"], "294560": ["Mitochondrial calcium ion transport", "Processing of SMDT1"], "294568": ["Regulation of actin dynamics for phagocytic cup formation", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate WASPs and WAVEs"], "294595": ["mRNA decay by 3' to 5' exoribonuclease"], "29461": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "29462": ["Vasopressin-like receptors", "G alpha (q) signalling events"], "29464": ["Amino acid transport across the plasma membrane", "Na+/Cl- dependent neurotransmitter transporters"], "294643": ["Platelet degranulation "], "29465": ["TRP channels"], "294672": ["Mitochondrial translation termination"], "294687": ["RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "29469": ["Toll Like Receptor 4 (TLR4) Cascade", "Transfer of LPS from LBP carrier to CD14", "Regulation of TLR by endogenous ligand"], "294693": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "mRNA Capping", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase I Transcription Termination", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE"], "294696": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "294698": ["Insulin processing", "Zinc efflux and compartmentalization by the SLC30 family"], "294709": ["RAB GEFs exchange GTP for GDP on RABs"], "29471": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "294711": ["mRNA Splicing - Major Pathway"], "294712": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Deposition of new CENPA-containing nucleosomes at the centromere", "Mitotic Prometaphase"], "29473": ["Phase I - Functionalization of compounds"], "294744": ["Detoxification of Reactive Oxygen Species"], "294753": ["Molybdenum cofactor biosynthesis"], "294767": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "29477": ["Caspase-mediated cleavage of cytoskeletal proteins"], "29479": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "294790": ["APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "SCF(Skp2)-mediated degradation of p27/p21", "Ub-specific processing proteases", "Orc1 removal from chromatin", "Cyclin D associated events in G1", "Regulation of RUNX2 expression and activity", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "294797": ["Interleukin-7 signaling", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "29480": ["G alpha (q) signalling events", "G alpha (i) signalling events"], "294800": ["Activation of ATR in response to replication stress", "HDR through Single Strand Annealing (SSA)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange"], "294807": ["G alpha (i) signalling events", "Relaxin receptors"], "294809": ["O-glycosylation of TSR domain-containing proteins"], "29481": ["Inactivation, recovery and regulation of the phototransduction cascade", "G alpha (i) signalling events", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "29483": ["Astrocytic Glutamate-Glutamine Uptake And Metabolism", "Glutamate Neurotransmitter Release Cycle", "Transport of inorganic cations/anions and amino acids/oligopeptides"], "29484": ["Amino acid transport across the plasma membrane"], "29485": ["Amino acid transport across the plasma membrane"], "294853": ["Keratinization", "Formation of the cornified envelope"], "29486": ["Separation of Sister Chromatids", "Establishment of Sister Chromatid Cohesion", "Cohesin Loading onto Chromatin", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA damage response and repair proteins"], "294862": ["ER Quality Control Compartment (ERQC)"], "29487": ["Glutathione conjugation"], "29489": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Regulation of PLK1 Activity at G2/M Transition", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "RHO GTPases Activate Formins", "Neutrophil degranulation", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "AURKA Activation by TPX2"], "294900": ["Golgi Associated Vesicle Biogenesis"], "29491": ["NRAGE signals death through JNK", "Rho GTPase cycle", "EPHB-mediated forward signaling", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "294912": ["XBP1(S) activates chaperone genes"], "294917": ["Oxidative Stress Induced Senescence"], "29492": ["Pre-NOTCH Processing in Golgi", "NOTCH2 intracellular domain regulates transcription", "NOTCH2 Activation and Transmission of Signal to the Nucleus", "Notch-HLH transcription pathway"], "294930": ["LDL clearance"], "29495": ["Trafficking of AMPA receptors", "Unblocking of NMDA receptors, glutamate binding and activation", "Activation of Ca-permeable Kainate Receptor", "RHO GTPases activate CIT", "RAF/MAP kinase cascade", "LGI-ADAM interactions", "Neurexins and neuroligins", "Synaptic adhesion-like molecules"], "29496": ["Signaling by ERBB2", "Signaling by ERBB4", "SHC1 events in ERBB2 signaling", "PIP3 activates AKT signaling", "GRB7 events in ERBB2 signaling", "Downregulation of ERBB2:ERBB3 signaling", "PI3K events in ERBB2 signaling", "RAF/MAP kinase cascade", "ERBB2 Regulates Cell Motility", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "ERBB2 Activates PTK6 Signaling", "Downregulation of ERBB2 signaling"], "294961": ["Ca2+ activated K+ channels"], "294963": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "294964": ["Respiratory electron transport", "Complex I biogenesis"], "294973": ["Complex I biogenesis"], "294975": ["mRNA decay by 3' to 5' exoribonuclease", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "KSRP (KHSRP) binds and destabilizes mRNA", "Major pathway of rRNA processing in the nucleolus and cytosol"], "29498": ["Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation"], "294981": ["EGFR downregulation"], "294993": ["Regulation of HSF1-mediated heat shock response"], "29501": ["Cation-coupled Chloride cotransporters"], "29502": ["Sodium-coupled phosphate cotransporters"], "29503": ["Norepinephrine Neurotransmitter Release Cycle", "Abacavir transmembrane transport", "Na+/Cl- dependent neurotransmitter transporters", "Organic cation transport"], "29504": ["Abacavir transmembrane transport", "Organic cation transport"], "295041": ["Stimuli-sensing channels"], "295050": ["mRNA decay by 3' to 5' exoribonuclease", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "KSRP (KHSRP) binds and destabilizes mRNA", "Major pathway of rRNA processing in the nucleolus and cytosol"], "295051": ["Synthesis of dolichyl-phosphate-glucose"], "295052": ["G0 and Early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Regulation of APC/C activators between G1/S and early anaphase", "SCF(Skp2)-mediated degradation of p27/p21", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "Ub-specific processing proteases", "Processing of DNA double-strand break ends", "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "Regulation of TP53 Degradation", "G2 Phase", "Orc1 removal from chromatin", "CDK-mediated phosphorylation and removal of Cdc6", "Cyclin A/B1/B2 associated events during G2/M transition", "p53-Dependent G1 DNA Damage Response", "Cyclin A:Cdk2-associated events at S phase entry"], "295062": ["Signaling by Hippo", "YAP1- and WWTR1 (TAZ)-stimulated gene expression", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription"], "29509": ["Organic anion transport"], "29510": ["Synthesis of PC", "Mitochondrial Fatty Acid Beta-Oxidation"], "295106": ["Intraflagellar transport"], "295107": ["Condensation of Prophase Chromosomes", "Condensation of Prometaphase Chromosomes"], "29512": ["Chromatin modifying enzymes"], "295143": ["Respiratory electron transport"], "29517": ["Stimuli-sensing channels", "Regulation of TP53 Degradation"], "295180": ["Antimicrobial peptides"], "295190": ["Formation of the cornified envelope"], "295217": ["Golgi Associated Vesicle Biogenesis"], "295224": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "295229": ["Nicotinamide salvaging"], "295230": ["Association of TriC/CCT with target proteins during biosynthesis", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "295234": ["Macroautophagy", "mTOR signalling", "mTORC1-mediated signalling", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "MAP2K and MAPK activation", "Neutrophil degranulation", "Regulation of PTEN gene transcription"], "295238": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "295245": ["Cellular hexose transport"], "295251": ["Formation of the beta-catenin:TCF transactivating complex", "Deactivation of the beta-catenin transactivating complex"], "295252": ["Antigen processing: Ubiquitination & Proteasome degradation"], "29526": ["Acyl chain remodelling of PS", "Acyl chain remodelling of PG"], "295261": ["Striated Muscle Contraction"], "29527": ["Nicotinamide salvaging", "Synthesis of 15-eicosatetraenoic acid derivatives", "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "Biosynthesis of EPA-derived SPMs", "Biosynthesis of DPAn-3 SPMs", "Biosynthesis of electrophilic \u03c9-3 PUFA oxo-derivatives"], "295270": ["mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "295274": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HATs acetylate histones", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "E3 ubiquitin ligases ubiquitinate target proteins", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "295277": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "SUMOylation of chromatin organization proteins", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "295279": ["Cross-presentation of soluble exogenous antigens (endosomes)", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis"], "29528": ["ER-Phagosome pathway", "Retrograde transport at the Trans-Golgi-Network", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "295284": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "29530": ["Signaling by BMP"], "295305": ["Synthesis of PA"], "29531": ["Phenylalanine and tyrosine catabolism"], "295310": ["Generic Transcription Pathway"], "295333": ["RAB GEFs exchange GTP for GDP on RABs"], "295334": ["mRNA Splicing - Major Pathway"], "295338": ["Phosphorylation of CD3 and TCR zeta chains"], "29534": ["E3 ubiquitin ligases ubiquitinate target proteins", "Peroxisomal protein import"], "295342": ["Rho GTPase cycle", "G alpha (12/13) signalling events", "Sema4D induced cell migration and growth-cone collapse", "RHO GTPases activate PKNs", "RHO GTPases activate CIT", "RHO GTPases Activate ROCKs", "RHO GTPases Activate Formins"], "295347": ["ARMS-mediated activation", "Integrin alphaIIb beta3 signaling", "GRB2:SOS provides linkage to MAPK signaling for Integrins ", "p130Cas linkage to MAPK signaling for integrins", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Rap1 signalling", "MAP2K and MAPK activation", "Neutrophil degranulation", "MET activates RAP1 and RAC1"], "295351": ["Digestion of dietary carbohydrate"], "295352": ["Digestion of dietary carbohydrate"], "295357": ["Macroautophagy", "mTOR signalling", "mTORC1-mediated signalling", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Regulation of PTEN gene transcription"], "295360": ["Voltage gated Potassium channels"], "295378": ["GPVI-mediated activation cascade", "NRAGE signals death through JNK", "Rho GTPase cycle", "Regulation of actin dynamics for phagocytic cup formation", "DAP12 signaling", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "EPH-ephrin mediated repulsion of cells", "VEGFA-VEGFR2 Pathway", "VEGFR2 mediated vascular permeability"], "29538": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "295384": ["RMTs methylate histone arginines", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"], "29539": ["Ethanol oxidation"], "295394": ["Synthesis of diphthamide-EEF2"], "29540": ["Cholesterol biosynthesis"], "295401": ["Lysosphingolipid and LPA receptors"], "29541": ["Cleavage of the damaged pyrimidine ", "Displacement of DNA glycosylase by APEX1"], "29542": ["MAP2K and MAPK activation", "Negative regulation of MAPK pathway"], "295428": ["Processing of Capped Intron-Containing Pre-mRNA"], "29543": ["Activation of Matrix Metalloproteinases", "Neutrophil degranulation"], "295430": ["HS-GAG biosynthesis"], "295445": ["Negative regulation of TCF-dependent signaling by WNT ligand antagonists"], "295448": ["RNA polymerase II transcribes snRNA genes"], "29545": ["UCH proteinases"], "295455": ["Zinc influx into cells by the SLC39 gene family"], "295458": ["Synthesis of Ketone Bodies"], "29546": ["Neurexins and neuroligins"], "295461": ["COPII-mediated vesicle transport", "MHC class II antigen presentation", "Cargo concentration in the ER", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "295462": ["Mitochondrial calcium ion transport", "Processing of SMDT1"], "29547": ["Neurexins and neuroligins"], "29548": ["Neurexins and neuroligins"], "295498": ["Ethanol oxidation"], "295500": ["Inactivation, recovery and regulation of the phototransduction cascade"], "29553": ["TWIK-releated acid-sensitive K+ channel (TASK)", "Phase 4 - resting membrane potential"], "295543": ["Attachment of GPI anchor to uPAR"], "29555": ["G alpha (s) signalling events", "Glucagon-type ligand receptors"], "29556": ["Striated Muscle Contraction"], "295568": ["E3 ubiquitin ligases ubiquitinate target proteins"], "295586": ["Stimuli-sensing channels"], "295596": ["Activation of ATR in response to replication stress", "Assembly of the ORC complex at the origin of replication", "CDC6 association with the ORC:origin complex", "CDT1 association with the CDC6:ORC:origin complex", "Assembly of the pre-replicative complex", "Orc1 removal from chromatin", "Activation of the pre-replicative complex"], "29560": ["Regulation of gene expression by Hypoxia-inducible Factor", "Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Ub-specific processing proteases", "PTK6 promotes HIF1A stabilization", "Neddylation"], "295607": ["mRNA Splicing - Major Pathway"], "29562": ["5-Phosphoribose 1-diphosphate biosynthesis"], "295620": ["Pyrimidine salvage"], "295625": ["Keratinization", "Formation of the cornified envelope"], "295631": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PS", "Acyl chain remodelling of PE", "Acyl chain remodelling of PI", "Acyl chain remodelling of PG", "Synthesis of PA"], "295635": ["Rho GTPase cycle"], "295645": ["Bicarbonate transporters"], "295647": ["Neutrophil degranulation"], "29565": ["Peptide chain elongation", "Synthesis of diphthamide-EEF2", "Neutrophil degranulation", "Protein methylation"], "295661": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "295669": ["Iron uptake and transport"], "29569": ["Collagen biosynthesis and modifying enzymes"], "295692": ["Transport of Mature mRNA derived from an Intron-Containing Transcript", "SUMOylation of DNA damage response and repair proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of DNA replication proteins"], "295703": ["Platelet degranulation ", "Intrinsic Pathway of Fibrin Clot Formation", "Regulation of Complement cascade"], "295704": ["ISG15 antiviral mechanism", "Termination of translesion DNA synthesis", "Antigen processing: Ubiquitination & Proteasome degradation"], "295706": ["Neutrophil degranulation"], "295707": ["Deadenylation of mRNA", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "29571": ["Phase 0 - rapid depolarisation"], "295712": ["Olfactory Signaling Pathway"], "295713": ["Olfactory Signaling Pathway"], "295721": ["Olfactory Signaling Pathway"], "295728": ["Olfactory Signaling Pathway"], "295729": ["Olfactory Signaling Pathway"], "295732": ["Olfactory Signaling Pathway"], "295734": ["Olfactory Signaling Pathway"], "295735": ["Olfactory Signaling Pathway"], "295736": ["Olfactory Signaling Pathway"], "295741": ["Olfactory Signaling Pathway"], "295743": ["Olfactory Signaling Pathway"], "295744": ["Olfactory Signaling Pathway"], "295747": ["Olfactory Signaling Pathway"], "295750": ["Olfactory Signaling Pathway"], "295751": ["Olfactory Signaling Pathway"], "295754": ["Olfactory Signaling Pathway"], "295763": ["Olfactory Signaling Pathway"], "295765": ["Olfactory Signaling Pathway"], "295766": ["Olfactory Signaling Pathway"], "295767": ["Olfactory Signaling Pathway"], "295768": ["Olfactory Signaling Pathway"], "295772": ["Olfactory Signaling Pathway"], "295776": ["Olfactory Signaling Pathway"], "295781": ["Olfactory Signaling Pathway"], "295786": ["Olfactory Signaling Pathway"], "29580": ["Cholesterol biosynthesis"], "295801": ["Olfactory Signaling Pathway"], "29581": ["Serotonin receptors", "G alpha (q) signalling events"], "295813": ["Olfactory Signaling Pathway"], "29582": ["Reactions specific to the hybrid N-glycan synthesis pathway"], "295822": ["Olfactory Signaling Pathway"], "295827": ["Olfactory Signaling Pathway"], "295828": ["Olfactory Signaling Pathway"], "295829": ["Olfactory Signaling Pathway"], "295834": ["Olfactory Signaling Pathway"], "295835": ["Olfactory Signaling Pathway"], "295839": ["Olfactory Signaling Pathway"], "29584": ["Oligomerization of connexins into connexons"], "29585": ["Gap junction assembly"], "295858": ["Olfactory Signaling Pathway"], "29586": ["Gap junction assembly"], "295863": ["Olfactory Signaling Pathway"], "295865": ["Olfactory Signaling Pathway"], "295869": ["Olfactory Signaling Pathway"], "295870": ["Olfactory Signaling Pathway"], "295875": ["Olfactory Signaling Pathway"], "295876": ["Olfactory Signaling Pathway"], "295884": ["Olfactory Signaling Pathway"], "295885": ["Olfactory Signaling Pathway"], "295890": ["Olfactory Signaling Pathway"], "295891": ["Olfactory Signaling Pathway"], "295892": ["Olfactory Signaling Pathway"], "295907": ["Olfactory Signaling Pathway"], "29591": ["Downregulation of TGF-beta receptor signaling", "TGF-beta receptor signaling activates SMADs", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "Ub-specific processing proteases"], "295910": ["Olfactory Signaling Pathway"], "29592": ["Branched-chain amino acid catabolism"], "295923": ["Respiratory electron transport", "Complex I biogenesis"], "295929": ["Striated Muscle Contraction"], "29593": ["Creatine metabolism"], "295934": ["Keratan sulfate biosynthesis"], "29595": ["Serotonin receptors", "G alpha (q) signalling events"], "295956": ["Neutrophil degranulation", "Neddylation"], "29597": ["G alpha (q) signalling events", "P2Y receptors", "Surfactant metabolism"], "295971": ["Rho GTPase cycle"], "295975": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "29598": ["Reduction of cytosolic Ca++ levels", "Ion homeostasis", "Ion transport by P-type ATPases"], "29599": ["Reduction of cytosolic Ca++ levels", "Ion homeostasis", "Ion transport by P-type ATPases"], "29600": ["Reduction of cytosolic Ca++ levels", "Ion homeostasis", "Ion transport by P-type ATPases"], "29603": ["Branched-chain amino acid catabolism"], "296037": ["Olfactory Signaling Pathway"], "296060": ["Rho GTPase cycle"], "296072": ["Regulation of RAS by GAPs", "FGFRL1 modulation of FGFR1 signaling"], "296076": ["Neutrophil degranulation"], "296086": ["Complex I biogenesis"], "296091": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PS", "Acyl chain remodelling of PE", "Acyl chain remodelling of PI", "Hydrolysis of LPC"], "296099": ["SUMOylation of transcription factors", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "G2/M DNA damage checkpoint"], "296102": ["RNA polymerase II transcribes snRNA genes"], "29611": ["Glyoxylate metabolism and glycine degradation", "Branched-chain amino acid catabolism"], "296121": ["Downregulation of ERBB2:ERBB3 signaling", "Regulation of FZD by ubiquitination", "Ub-specific processing proteases"], "296126": ["mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "296128": ["Synthesis of PC"], "29613": ["Receptor-type tyrosine-protein phosphatases", "NTF3 activates NTRK3 signaling", "Activated NTRK3 signals through PLCG1", "Activated NTRK3 signals through PI3K"], "296130": ["Synthesis of PA", "Triglyceride biosynthesis"], "296134": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "296137": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "296138": ["Beta-oxidation of pristanoyl-CoA"], "29614": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "296161": ["Antigen processing: Ubiquitination & Proteasome degradation"], "296167": ["Coenzyme A biosynthesis"], "296178": ["Activation of ATR in response to replication stress", "CDC6 association with the ORC:origin complex", "CDT1 association with the CDC6:ORC:origin complex", "Assembly of the pre-replicative complex", "Orc1 removal from chromatin", "Activation of the pre-replicative complex"], "296188": ["Sphingolipid de novo biosynthesis"], "29619": ["TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "296190": ["Complex I biogenesis"], "296199": ["Golgi Associated Vesicle Biogenesis"], "296219": ["Transport of Mature mRNA derived from an Intron-Containing Transcript"], "29622": ["p38MAPK events"], "29623": ["Glucuronidation"], "29624": ["Synthesis of 5-eicosatetraenoic acids", "Synthesis of Leukotrienes (LT) and Eoxins (EX)", "Synthesis of Lipoxins (LX)"], "29625": ["Class B/2 (Secretin family receptors)"], "296259": ["Ethanol oxidation"], "296269": ["Tie2 Signaling"], "29628": ["Activation of AMPA receptors", "Trafficking of AMPA receptors", "Trafficking of GluR2-containing AMPA receptors", "Synaptic adhesion-like molecules"], "296284": ["MHC class II antigen presentation", "Intraflagellar transport", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "296285": ["Neddylation"], "29629": ["Activation of AMPA receptors", "Trafficking of AMPA receptors", "Trafficking of GluR2-containing AMPA receptors", "Synaptic adhesion-like molecules"], "296290": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Antimicrobial peptides", "Post-translational protein phosphorylation"], "29630": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "296302": ["L13a-mediated translational silencing of Ceruloplasmin expression", "ABC-family proteins mediated transport", "Translation initiation complex formation", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Recycling of eIF2:GDP"], "29631": ["COPII-mediated vesicle transport", "COPI-mediated anterograde transport"], "29632": ["Mineralocorticoid biosynthesis"], "296320": ["mRNA Splicing - Major Pathway"], "296321": ["Toll Like Receptor 4 (TLR4) Cascade", "Neutrophil degranulation", "Antimicrobial peptides"], "29633": ["HS-GAG biosynthesis"], "29634": ["Pyruvate metabolism"], "296350": ["Serine biosynthesis"], "296356": ["Neutrophil degranulation"], "296358": ["ECM proteoglycans"], "296368": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Antigen processing: Ubiquitination & Proteasome degradation"], "296369": ["Striated Muscle Contraction"], "29637": ["Cholesterol biosynthesis"], "296371": ["HDL remodeling"], "29639": ["Ion homeostasis", "Ion transport by P-type ATPases"], "296390": ["NOD1/2 Signaling Pathway", "Downstream TCR signaling", "FCERI mediated NF-kB activation", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "CLEC7A (Dectin-1) signaling", "Interleukin-1 signaling", "IRAK1 recruits IKK complex", "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "Antigen processing: Ubiquitination & Proteasome degradation"], "296394": ["Synthesis of dolichyl-phosphate mannose"], "296395": ["Voltage gated Potassium channels"], "29642": ["Glutamate Neurotransmitter Release Cycle", "Amino acid transport across the plasma membrane"], "296461": ["Synthesis of bile acids and bile salts"], "296472": ["PTK6 Down-Regulation"], "29648": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase", "Mitotic Telophase/Cytokinesis"], "296488": ["Platelet degranulation "], "29650": ["Degradation of the extracellular matrix", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Neutrophil degranulation", "Post-translational protein phosphorylation", "NOTCH3 Activation and Transmission of Signal to the Nucleus"], "296501": ["HATs acetylate histones"], "29653": ["Synthesis of PA", "Triglyceride biosynthesis"], "296532": ["Hedgehog 'on' state"], "296541": ["Interleukin-36 pathway"], "296545": ["Terminal pathway of complement", "Regulation of Complement cascade"], "296551": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "296558": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6", "Antigen processing: Ubiquitination & Proteasome degradation"], "296562": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "296578": ["Transport of fatty acids"], "296588": ["Processing of SMDT1"], "29659": ["Elevation of cytosolic Ca2+ levels", "Platelet homeostasis"], "296600": ["Cellular hexose transport"], "296603": ["GPVI-mediated activation cascade", "NRAGE signals death through JNK", "Rho GTPase cycle", "Regulation of actin dynamics for phagocytic cup formation", "DAP12 signaling", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "EPH-ephrin mediated repulsion of cells", "VEGFA-VEGFR2 Pathway", "VEGFR2 mediated vascular permeability"], "296618": ["Intraflagellar transport"], "29662": ["Rho GTPase cycle", "Neutrophil degranulation", "RAB GEFs exchange GTP for GDP on RABs"], "296623": ["Synthesis of PA"], "296624": ["Synthesis of Dolichyl-phosphate"], "296627": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "29663": ["MHC class II antigen presentation", "Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis"], "296648": ["PIP3 activates AKT signaling", "CD28 dependent PI3K/Akt signaling", "VEGFR2 mediated vascular permeability"], "296649": ["Retrograde transport at the Trans-Golgi-Network"], "29665": ["Elevation of cytosolic Ca2+ levels", "Platelet homeostasis", "The NLRP3 inflammasome"], "296651": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "296653": ["PRC2 methylates histones and DNA"], "296654": ["Caspase-mediated cleavage of cytoskeletal proteins", "Neutrophil degranulation"], "296655": ["Stimuli-sensing channels", "Neutrophil degranulation"], "296658": ["Respiratory electron transport", "Complex I biogenesis"], "29666": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "29667": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing"], "296675": ["Olfactory Signaling Pathway"], "296678": ["Olfactory Signaling Pathway"], "296679": ["Olfactory Signaling Pathway"], "29668": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "296682": ["Olfactory Signaling Pathway"], "296687": ["Olfactory Signaling Pathway"], "296689": ["Olfactory Signaling Pathway"], "29669": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "Neutrophil degranulation", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "296694": ["Olfactory Signaling Pathway"], "29670": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "29671": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "29672": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "Neutrophil degranulation", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "29673": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "296732": ["RMTs methylate histone arginines", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "296733": ["Chondroitin sulfate biosynthesis"], "29674": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "29675": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "29676": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "29678": ["mRNA Splicing - Major Pathway"], "296789": ["Other semaphorin interactions"], "29681": ["Intrinsic Pathway of Fibrin Clot Formation"], "29684": ["DAP12 interactions", "DAP12 signaling"], "296849": ["Regulation of pyruvate dehydrogenase (PDH) complex", "Signaling by Retinoic Acid"], "29685": ["Activation of ATR in response to replication stress", "Assembly of the pre-replicative complex", "Orc1 removal from chromatin", "Activation of the pre-replicative complex", "Switching of origins to a post-replicative state"], "296851": ["Synthesis of 5-eicosatetraenoic acids"], "29686": ["Phase 0 - rapid depolarisation"], "296872": ["TNFs bind their physiological receptors"], "29688": ["Synthesis of IPs in the ER lumen"], "296883": ["Translesion synthesis by REV1", "Recognition of DNA damage by PCNA-containing replication complex", "Translesion Synthesis by POLH", "Removal of the Flap Intermediate from the C-strand", "Activation of ATR in response to replication stress", "Regulation of HSF1-mediated heat shock response", "Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "PCNA-Dependent Long Patch Base Excision Repair", "Translesion synthesis by POLK", "Translesion synthesis by POLI", "Termination of translesion DNA synthesis", "HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Formation of Incision Complex in GG-NER", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Fanconi Anemia Pathway", "Activation of the pre-replicative complex", "Removal of the Flap Intermediate"], "29691": ["Cam-PDE 1 activation", "cGMP effects", "G alpha (s) signalling events"], "296913": ["mRNA Splicing - Major Pathway"], "29692": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PS", "Acyl chain remodelling of PE", "Acyl chain remodelling of PI", "Acyl chain remodelling of PG", "Synthesis of PA", "Antimicrobial peptides"], "29693": ["Reduction of cytosolic Ca++ levels", "Ion homeostasis", "Ion transport by P-type ATPases"], "29694": ["GABA A (rho) receptor activation"], "29695": ["GABA A (rho) receptor activation"], "296969": ["Transport of nucleotide sugars"], "296972": ["Estrogen biosynthesis", "Retinoid metabolism and transport"], "296973": ["Glycolysis"], "296981": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "296988": ["AKT phosphorylates targets in the cytosol", "Regulation of PTEN stability and activity", "Antigen processing: Ubiquitination & Proteasome degradation"], "29699": ["PKA activation", "PKA activation in glucagon signalling", "DARPP-32 events", "Vasopressin regulates renal water homeostasis via Aquaporins", "CREB1 phosphorylation through the activation of Adenylate Cyclase", "Hedgehog 'off' state", "Factors involved in megakaryocyte development and platelet production"], "296995": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "29700": ["Phenylalanine and tyrosine catabolism"], "29701": ["Phase 0 - rapid depolarisation"], "29702": ["PERK regulates gene expression"], "297025": ["Peptide ligand-binding receptors"], "297029": ["Glutathione conjugation", "Peroxisomal protein import"], "29705": ["GABA A receptor activation"], "297065": ["Generic Transcription Pathway"], "297066": ["Generic Transcription Pathway"], "29707": ["GABA A receptor activation"], "297073": ["Platelet degranulation "], "297081": ["Phase I - Functionalization of compounds", "Neutrophil degranulation"], "29709": ["GABA A receptor activation"], "29712": ["Activation of G protein gated Potassium channels", "Classical Kir channels", "Phase 4 - resting membrane potential", "Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "29713": ["Activation of G protein gated Potassium channels", "Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "29714": ["Neutrophil degranulation"], "29715": ["Reduction of cytosolic Ca++ levels", "Sodium/Calcium exchangers", "Ion homeostasis"], "297176": ["Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components", "Inactivation of APC/C via direct inhibition of the APC/C complex", "Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "APC/C:Cdc20 mediated degradation of mitotic proteins", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "29719": ["Activation of G protein gated Potassium channels", "Potassium transport channels", "Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "29722": ["Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"], "29723": ["Metabolism of folate and pterines"], "29725": ["Recycling of bile acids and salts", "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Peroxisomal protein import"], "29726": ["Import of palmitoyl-CoA into the mitochondrial matrix", "Organic cation transport"], "29728": ["Activation of ATR in response to replication stress", "Assembly of the pre-replicative complex", "Orc1 removal from chromatin", "Activation of the pre-replicative complex", "Switching of origins to a post-replicative state"], "29731": ["Voltage gated Potassium channels"], "29733": ["G alpha (i) signalling events", "Lysosphingolipid and LPA receptors"], "297334": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "297336": ["mRNA Splicing - Major Pathway"], "297337": ["E3 ubiquitin ligases ubiquitinate target proteins"], "29734": ["Regulation of HSF1-mediated heat shock response"], "29735": ["Proton-coupled monocarboxylate transport"], "29737": ["Voltage gated Potassium channels"], "297372": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "29738": ["Voltage gated Potassium channels", "Neutrophil degranulation"], "297383": ["RHO GTPases Activate Rhotekin and Rhophilins"], "297386": ["Bicarbonate transporters"], "297387": ["Signaling by Hippo"], "297389": ["Purine salvage"], "29739": ["Glutathione synthesis and recycling"], "297393": ["Synthesis of UDP-N-acetyl-glucosamine"], "29740": ["mitochondrial fatty acid beta-oxidation of unsaturated fatty acids"], "297406": ["Association of TriC/CCT with target proteins during biosynthesis", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "29741": ["PI3K Cascade", "IRS-mediated signalling", "GPVI-mediated activation cascade", "PIP3 activates AKT signaling", "Interleukin-7 signaling", "Signaling by SCF-KIT", "Synthesis of PIPs at the plasma membrane", "Downstream signal transduction", "Rho GTPase cycle", "PI3K/AKT activation", "Downstream TCR signaling", "Role of phospholipids in phagocytosis", "Tie2 Signaling", "DAP12 signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "Costimulation by the CD28 family", "CD28 dependent PI3K/Akt signaling", "G alpha (q) signalling events", "VEGFA-VEGFR2 Pathway", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "RET signaling", "Interleukin receptor SHC signaling", "Regulation of signaling by CBL"], "297417": ["Synthesis of UDP-N-acetyl-glucosamine"], "297428": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "29743": ["Fatty acyl-CoA biosynthesis"], "297433": ["Cytosolic sulfonation of small molecules"], "297455": ["mRNA decay by 5' to 3' exoribonuclease", "mRNA Splicing - Major Pathway"], "297459": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "29747": ["Ca2+ activated K+ channels"], "29748": ["Activation of BAD and translocation to mitochondria ", "Calcineurin activates NFAT", "FCERI mediated Ca+2 mobilization", "Ca2+ pathway", "CLEC7A (Dectin-1) induces NFAT activation"], "297481": ["ISG15 antiviral mechanism"], "297486": ["Processing of DNA double-strand break ends"], "29750": ["O-linked glycosylation of mucins"], "297508": ["Nicotinamide salvaging"], "29751": ["Sema3A PAK dependent Axon repulsion", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "CRMPs in Sema3A signaling"], "297518": ["Regulation of actin dynamics for phagocytic cup formation", "EPHB-mediated forward signaling", "RHO GTPases Activate WASPs and WAVEs", "Clathrin-mediated endocytosis"], "297520": ["Interleukin-17 signaling"], "297522": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "COPII-mediated vesicle transport", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA damage response and repair proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "RHO GTPases Activate Formins", "Mitotic Prometaphase", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "29753": ["Activation of BAD and translocation to mitochondria ", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Signaling by Hippo", "NADE modulates death signalling", "Regulation of PLK1 Activity at G2/M Transition", "Regulation of HSF1-mediated heat shock response", "HSF1 activation", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "RHO GTPases activate PKNs", "TP53 Regulates Metabolic Genes", "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "AURKA Activation by TPX2", "RAB GEFs exchange GTP for GDP on RABs"], "297554": ["Chondroitin sulfate biosynthesis"], "297561": ["SUMOylation of DNA damage response and repair proteins", "HDR through Single Strand Annealing (SSA)"], "29757": ["ROS, RNS production in phagocytes", "Neutrophil degranulation", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "297570": ["Peroxisomal protein import"], "297592": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "297593": ["Ub-specific processing proteases", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes"], "297595": ["Collagen biosynthesis and modifying enzymes"], "297596": ["MHC class II antigen presentation"], "297597": ["HATs acetylate histones"], "297601": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "297604": ["TNFR2 non-canonical NF-kB pathway", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "297682": ["RAF-independent MAPK1/3 activation", "Negative regulation of MAPK pathway"], "297685": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "297694": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PE", "Acyl chain remodelling of PI", "Hydrolysis of LPC"], "297695": ["mRNA Splicing - Major Pathway"], "297699": ["Downregulation of TGF-beta receptor signaling"], "297705": ["PRC2 methylates histones and DNA", "PKMTs methylate histone lysines"], "297727": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "297757": ["O-glycosylation of TSR domain-containing proteins"], "297758": ["DNA Damage/Telomere Stress Induced Senescence"], "297795": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "297797": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "297799": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "297805": ["RA biosynthesis pathway"], "297822": ["Regulation of TP53 Activity through Phosphorylation"], "297865": ["Dermatan sulfate biosynthesis"], "297872": ["TBC/RABGAPs"], "297893": ["G0 and Early G1", "Formation of the beta-catenin:TCF transactivating complex", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "Deactivation of the beta-catenin transactivating complex", "SUMOylation of chromatin organization proteins", "Regulation of TP53 Activity through Acetylation", "RNA Polymerase I Transcription Initiation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Regulation of PTEN gene transcription", "Estrogen-dependent gene expression", "Regulation of MECP2 expression and activity", "Factors involved in megakaryocyte development and platelet production"], "297894": ["ECM proteoglycans"], "297910": ["Multifunctional anion exchangers"], "297930": ["Downregulation of ERBB4 signaling", "Stimuli-sensing channels", "Antigen processing: Ubiquitination & Proteasome degradation"], "297932": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "297960": ["Macroautophagy", "mTOR signalling", "mTORC1-mediated signalling", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Regulation of PTEN gene transcription"], "297989": ["ISG15 antiviral mechanism", "Ub-specific processing proteases", "OAS antiviral response", "Negative regulators of DDX58/IFIH1 signaling"], "297990": ["Respiratory electron transport", "Complex I biogenesis"], "297995": ["Endosomal Sorting Complex Required For Transport (ESCRT)"], "297998": ["Detoxification of Reactive Oxygen Species"], "298003": ["Galactose catabolism"], "298006": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "298012": ["N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "Josephin domain DUBs", "DNA Damage Recognition in GG-NER", "Formation of Incision Complex in GG-NER"], "298038": ["Olfactory Signaling Pathway"], "298039": ["Olfactory Signaling Pathway"], "298040": ["Olfactory Signaling Pathway"], "298042": ["Olfactory Signaling Pathway"], "298044": ["Olfactory Signaling Pathway"], "298045": ["Olfactory Signaling Pathway"], "298046": ["Olfactory Signaling Pathway"], "298065": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "298066": ["Neutrophil degranulation"], "298068": ["XBP1(S) activates chaperone genes"], "298069": ["Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Assembly of collagen fibrils and other multimeric structures", "Collagen chain trimerization"], "298071": ["Sialic acid metabolism"], "298074": ["Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER"], "298075": ["Cleavage of Growing Transcript in the Termination Region ", "SLBP independent Processing of Histone Pre-mRNAs", "Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "RNA Polymerase II Pre-transcription Events", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "mRNA 3'-end processing", "Processing of Capped Intron-Containing Pre-mRNA", "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "Processing of Intronless Pre-mRNAs", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "298095": ["mRNA Splicing - Major Pathway"], "298101": ["Collagen biosynthesis and modifying enzymes", "Assembly of collagen fibrils and other multimeric structures", "MET activates PTK2 signaling", "Collagen chain trimerization"], "298103": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "298184": ["eNOS activation"], "298203": ["Processing of SMDT1"], "298205": ["Interferon alpha/beta signaling", "Regulation of IFNA signaling"], "298211": ["Interferon alpha/beta signaling", "Regulation of IFNA signaling"], "298213": ["Interferon alpha/beta signaling", "Regulation of IFNA signaling"], "298227": ["Methionine salvage pathway"], "298247": ["Metalloprotease DUBs"], "298280": ["Formation of the active cofactor, UDP-glucuronate", "Transport of nucleotide sugars"], "298282": ["Regulation of Apoptosis"], "298288": ["Terminal pathway of complement", "Regulation of Complement cascade"], "298296": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "VLDLR internalisation and degradation", "Post-translational protein phosphorylation", "LDL clearance"], "298317": ["Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "E3 ubiquitin ligases ubiquitinate target proteins", "Antigen processing: Ubiquitination & Proteasome degradation"], "298340": ["Amino acid transport across the plasma membrane", "Na+/Cl- dependent neurotransmitter transporters"], "298374": ["mRNA Splicing - Major Pathway"], "298376": ["Detoxification of Reactive Oxygen Species"], "298385": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "298396": ["Olfactory Signaling Pathway"], "298400": ["CREB3 factors activate genes"], "298404": ["NRAGE signals death through JNK", "Rho GTPase cycle"], "298410": ["Interconversion of nucleotide di- and triphosphates"], "298452": ["Synthesis of diphthamide-EEF2"], "298490": ["Coenzyme A biosynthesis"], "298496": ["Voltage gated Potassium channels"], "298504": ["Synthesis of PC"], "298508": ["Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Neutrophil degranulation", "mRNA Splicing - Major Pathway"], "298514": ["Macroautophagy", "mTOR signalling", "mTORC1-mediated signalling", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Regulation of PTEN gene transcription"], "298517": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "298518": ["Other interleukin signaling"], "298521": ["Activation of Ca-permeable Kainate Receptor", "Presynaptic function of Kainate receptors"], "298528": ["EPH-Ephrin signaling", "EPHA-mediated growth cone collapse", "EPH-ephrin mediated repulsion of cells"], "298533": ["MicroRNA (miRNA) biogenesis", "Small interfering RNA (siRNA) biogenesis", "Post-transcriptional silencing by small RNAs"], "298534": ["Apoptotic cleavage of cellular proteins", "Activation of ATR in response to replication stress", "Ub-specific processing proteases"], "298541": ["Synthesis of Dolichyl-phosphate"], "298558": ["Generic Transcription Pathway"], "298566": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Regulation of Complement cascade"], "298573": ["ISG15 antiviral mechanism"], "298575": ["Pink/Parkin Mediated Mitophagy"], "298576": ["Ub-specific processing proteases"], "298579": ["Acyl chain remodelling of PS", "Acyl chain remodelling of PG"], "298584": ["MHC class II antigen presentation", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic", "Factors involved in megakaryocyte development and platelet production"], "298595": ["Chromatin modifying enzymes"], "298596": ["Citric acid cycle (TCA cycle)"], "298598": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "298607": ["Agmatine biosynthesis"], "298653": ["Nicotinate metabolism"], "298657": ["Reversible hydration of carbon dioxide"], "298681": ["RNA polymerase II transcribes snRNA genes"], "298682": ["Neutrophil degranulation"], "298683": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "298688": ["RNA polymerase II transcribes snRNA genes"], "298689": ["Antigen processing: Ubiquitination & Proteasome degradation"], "298690": ["A tetrasaccharide linker sequence is required for GAG synthesis"], "298692": ["Carboxyterminal post-translational modifications of tubulin"], "298693": ["ISG15 antiviral mechanism", "Termination of translesion DNA synthesis"], "298696": ["RHO GTPases Activate NADPH Oxidases", "Regulation of TP53 Activity through Phosphorylation", "PI5P Regulates TP53 Acetylation", "Negative regulators of DDX58/IFIH1 signaling"], "298700": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "298702": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Integrin cell surface interactions"], "298748": ["Complex I biogenesis"], "298767": ["Intraflagellar transport"], "298786": ["Insulin processing", "Zinc efflux and compartmentalization by the SLC30 family"], "298792": ["Neutrophil degranulation"], "298845": ["Molecules associated with elastic fibres"], "29885": ["Anchoring of the basal body to the plasma membrane", "VxPx cargo-targeting to cilium", "BBSome-mediated cargo-targeting to cilium", "RAB GEFs exchange GTP for GDP on RABs"], "298850": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Deposition of new CENPA-containing nucleosomes at the centromere", "Mitotic Prometaphase"], "298881": ["Purine catabolism"], "298884": ["Resolution of D-loop Structures through Holliday Junction Intermediates"], "298908": ["Voltage gated Potassium channels"], "298934": ["Methionine salvage pathway"], "298941": ["Laminin interactions", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "MET activates PTK2 signaling", "Post-translational protein phosphorylation"], "298942": ["Regulation of pyruvate dehydrogenase (PDH) complex", "Glyoxylate metabolism and glycine degradation", "Signaling by Retinoic Acid", "Glycine degradation", "Pyruvate metabolism", "Branched-chain amino acid catabolism", "Lysine catabolism"], "298947": ["GPVI-mediated activation cascade", "Synthesis of PIPs at the plasma membrane", "G beta:gamma signalling through PI3Kgamma", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)"], "298954": ["5-Phosphoribose 1-diphosphate biosynthesis"], "299008": ["Complex I biogenesis"], "299012": ["Rho GTPase cycle"], "299027": ["L13a-mediated translational silencing of Ceruloplasmin expression", "ABC-family proteins mediated transport", "Translation initiation complex formation", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Recycling of eIF2:GDP"], "299052": ["Platelet degranulation ", "Neutrophil degranulation", "Gluconeogenesis"], "299075": ["COPII-mediated vesicle transport", "RAB GEFs exchange GTP for GDP on RABs"], "299106": ["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "299112": ["Recognition of DNA damage by PCNA-containing replication complex", "Telomere C-strand synthesis initiation", "PCNA-Dependent Long Patch Base Excision Repair", "Termination of translesion DNA synthesis", "HDR through Homologous Recombination (HRR)", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "DNA replication initiation", "Activation of the pre-replicative complex"], "299116": ["Signaling by Hippo"], "299121": ["MHC class II antigen presentation", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Neutrophil degranulation", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic"], "299145": ["Rho GTPase cycle"], "299147": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Degradation of beta-catenin by the destruction complex", "Beta-catenin phosphorylation cascade", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "CTLA4 inhibitory signaling", "RHO GTPases Activate Formins", "RAF activation", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Mitotic Prometaphase"], "299156": ["RAB geranylgeranylation"], "299159": ["ROS, RNS production in phagocytes", "Neutrophil degranulation", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "299193": ["Beta-oxidation of very long chain fatty acids"], "299196": ["Cobalamin (Cbl, vitamin B12) transport and metabolism"], "299197": ["Antigen processing: Ubiquitination & Proteasome degradation"], "299198": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "299201": ["Glyoxylate metabolism and glycine degradation", "Lysine catabolism"], "299209": ["Intraflagellar transport"], "299210": ["Nuclear Receptor transcription pathway"], "299236": ["Downstream signaling of activated FGFR1"], "299242": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (q) signalling events"], "299246": ["BBSome-mediated cargo-targeting to cilium"], "299256": ["Cleavage of Growing Transcript in the Termination Region ", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "299258": ["Intra-Golgi traffic"], "299266": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "299276": ["Platelet degranulation ", "Neutrophil degranulation"], "299279": ["Platelet degranulation ", "Neutrophil degranulation"], "299284": ["MicroRNA (miRNA) biogenesis", "Small interfering RNA (siRNA) biogenesis"], "299295": ["PKMTs methylate histone lysines"], "299310": ["Respiratory electron transport", "Complex I biogenesis"], "299314": ["Alternative complement activation", "Activation of C3 and C5", "O-glycosylation of TSR domain-containing proteins", "Neutrophil degranulation", "Regulation of Complement cascade"], "299331": ["Signaling by ERBB2", "Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "Regulation of actin dynamics for phagocytic cup formation", "eNOS activation", "Regulation of PLK1 Activity at G2/M Transition", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "HSF1 activation", "Attenuation phase", "HSF1-dependent transactivation", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Sema3A PAK dependent Axon repulsion", "VEGFA-VEGFR2 Pathway", "VEGFR2 mediated vascular permeability", "Anchoring of the basal body to the plasma membrane", "Neutrophil degranulation", "The role of GTSE1 in G2/M progression after G2 checkpoint", "AURKA Activation by TPX2", "Downregulation of ERBB2 signaling", "ESR-mediated signaling", "Estrogen-dependent gene expression"], "299346": ["Synthesis of dolichyl-phosphate-glucose"], "299347": ["RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter"], "299514": ["Pink/Parkin Mediated Mitophagy"], "299555": ["Fatty acyl-CoA biosynthesis"], "299566": ["Fatty acids", "Miscellaneous substrates", "Eicosanoids", "Synthesis of Leukotrienes (LT) and Eoxins (EX)"], "299586": ["Olfactory Signaling Pathway"], "299587": ["Formation of the cornified envelope"], "299588": ["Olfactory Signaling Pathway"], "299589": ["Olfactory Signaling Pathway"], "299596": ["Olfactory Signaling Pathway"], "299602": ["Downstream TCR signaling", "FCERI mediated NF-kB activation", "CLEC7A (Dectin-1) signaling", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Antigen processing: Ubiquitination & Proteasome degradation"], "299604": ["Mitochondrial transcription initiation"], "299606": ["Degradation of the extracellular matrix", "Activation of Matrix Metalloproteinases", "Neutrophil degranulation", "Antimicrobial peptides", "Regulation of Complement cascade"], "299609": ["ABC transporters in lipid homeostasis"], "299616": ["Ion transport by P-type ATPases"], "299620": ["mRNA Splicing - Major Pathway"], "299628": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "299638": ["Processing of DNA double-strand break ends"], "299643": ["Respiratory electron transport", "Complex I biogenesis"], "299694": ["Regulation of TP53 Activity through Phosphorylation"], "299706": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA damage response and repair proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of DNA replication proteins", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "299714": ["Stimuli-sensing channels"], "299732": ["Synthesis of Leukotrienes (LT) and Eoxins (EX)", "Neutrophil degranulation", "Biosynthesis of E-series 18(S)-resolvins"], "299735": ["Histidine catabolism"], "299739": ["Respiratory electron transport", "Complex I biogenesis"], "299757": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "299766": ["CDO in myogenesis"], "299783": ["Neutrophil degranulation"], "299799": ["RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "299802": ["Regulation of FZD by ubiquitination"], "299805": ["Deadenylation of mRNA", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "299809": ["Association of TriC/CCT with target proteins during biosynthesis", "Neutrophil degranulation", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "299810": ["Activation of the TFAP2 (AP-2) family of transcription factors"], "299825": ["Keratan sulfate degradation", "Lysosome Vesicle Biogenesis", "Neutrophil degranulation"], "299827": ["Regulation of innate immune responses to cytosolic DNA", "STAT6-mediated induction of chemokines", "IRF3-mediated induction of type I IFN", "Interleukin-37 signaling", "Negative regulators of DDX58/IFIH1 signaling", "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon"], "299850": ["MHC class II antigen presentation", "Regulation of PLK1 Activity at G2/M Transition", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic", "AURKA Activation by TPX2"], "299857": ["Metabolism of folate and pterines"], "299858": ["Scavenging of heme from plasma", "Retinoid metabolism and transport"], "299872": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "299899": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "299903": ["Insulin processing", "Zinc efflux and compartmentalization by the SLC30 family"], "299907": ["HS-GAG biosynthesis"], "299909": ["Platelet degranulation "], "299928": ["Lectin pathway of complement activation", "Initial triggering of complement"], "299938": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "299954": ["Respiratory electron transport", "Complex I biogenesis"], "299957": ["SUMOylation of DNA damage response and repair proteins"], "299971": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "299976": ["Interconversion of nucleotide di- and triphosphates"], "300017": ["Post-translational modification: synthesis of GPI-anchored proteins"], "300025": ["Post-translational modification: synthesis of GPI-anchored proteins"], "300027": ["Post-translational modification: synthesis of GPI-anchored proteins", "Assembly of active LPL and LIPC lipase complexes", "Chylomicron remodeling"], "300030": ["RHO GTPases Activate Rhotekin and Rhophilins"], "300035": ["Amino acid synthesis and interconversion (transamination)"], "300036": ["GDP-fucose biosynthesis"], "300045": ["mRNA decay by 3' to 5' exoribonuclease", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "KSRP (KHSRP) binds and destabilizes mRNA", "Major pathway of rRNA processing in the nucleolus and cytosol"], "300046": ["Attachment of GPI anchor to uPAR"], "300050": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "300051": ["Zinc influx into cells by the SLC39 gene family"], "300052": ["Endosomal Sorting Complex Required For Transport (ESCRT)"], "300053": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "300054": ["Signaling by NODAL", "Signaling by Activin"], "300062": ["Intraflagellar transport"], "300069": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "300075": ["Pink/Parkin Mediated Mitophagy"], "300078": ["Retrograde neurotrophin signalling"], "300083": ["Alpha-oxidation of phytanate"], "300084": ["Recognition of DNA damage by PCNA-containing replication complex", "Prolactin receptor signaling", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Degradation of beta-catenin by the destruction complex", "Degradation of DVL", "Hedgehog 'on' state", "DNA Damage Recognition in GG-NER", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Orc1 removal from chromatin", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "Regulation of RUNX2 expression and activity", "Neddylation", "Interleukin-1 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "300088": ["RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "300089": ["Synthesis of GDP-mannose"], "300092": ["Major pathway of rRNA processing in the nucleolus and cytosol", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "300105": ["Carboxyterminal post-translational modifications of tubulin"], "300108": ["Triglyceride catabolism"], "300115": ["Rho GTPase cycle"], "300126": ["G2/M Checkpoints", "The role of GTSE1 in G2/M progression after G2 checkpoint"], "300129": ["Glycosphingolipid metabolism"], "300147": ["Synthesis of PIPs at the ER membrane", "RAB GEFs exchange GTP for GDP on RABs"], "300149": ["Condensation of Prophase Chromosomes"], "300160": ["PTK6 promotes HIF1A stabilization"], "300177": ["PIP3 activates AKT signaling", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Interleukin-1 signaling", "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "MyD88 dependent cascade initiated on endosome"], "300197": ["Generic Transcription Pathway"], "300206": ["HATs acetylate histones"], "300208": ["mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "300218": ["Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Recruitment of NuMA to mitotic centrosomes", "Recycling pathway of L1", "Hedgehog 'off' state", "Cilium Assembly", "Intraflagellar transport", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "Carboxyterminal post-translational modifications of tubulin", "Kinesins"], "300240": ["Macroautophagy"], "300242": ["Keratinization", "Formation of the cornified envelope"], "300247": ["Keratinization", "Formation of the cornified envelope"], "300248": ["Keratinization", "Formation of the cornified envelope"], "300250": ["Neutrophil degranulation", "Keratinization", "Formation of the cornified envelope"], "300253": ["L13a-mediated translational silencing of Ceruloplasmin expression", "mTORC1-mediated signalling", "Deadenylation of mRNA", "Translation initiation complex formation", "Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "300259": ["Transport of Mature mRNA derived from an Intron-Containing Transcript", "SUMOylation of DNA damage response and repair proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of DNA replication proteins"], "300266": ["Factors involved in megakaryocyte development and platelet production"], "300289": ["Signaling by Hippo"], "300320": ["Transcriptional Regulation by E2F6"], "300328": ["Vitamin B5 (pantothenate) metabolism"], "300339": ["Collagen degradation", "Degradation of the extracellular matrix", "Activation of Matrix Metalloproteinases", "Basigin interactions", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "300341": ["Collagen degradation", "Degradation of the extracellular matrix", "Assembly of collagen fibrils and other multimeric structures"], "300361": ["mRNA Splicing - Major Pathway"], "300384": ["Amino acid synthesis and interconversion (transamination)"], "300392": ["Olfactory Signaling Pathway"], "300400": ["Olfactory Signaling Pathway"], "300408": ["Olfactory Signaling Pathway"], "300414": ["Olfactory Signaling Pathway"], "300443": ["Lysosphingolipid and LPA receptors"], "300445": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "300447": ["MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "Complex I biogenesis", "TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "MyD88 cascade initiated on plasma membrane"], "300458": ["Peptide ligand-binding receptors", "G alpha (q) signalling events", "G alpha (s) signalling events"], "300474": ["O-glycosylation of TSR domain-containing proteins"], "300519": ["Cell surface interactions at the vascular wall"], "300524": ["Olfactory Signaling Pathway"], "300560": ["Olfactory Signaling Pathway"], "300607": ["Olfactory Signaling Pathway"], "300634": ["Olfactory Signaling Pathway"], "300635": ["Olfactory Signaling Pathway"], "300637": ["Olfactory Signaling Pathway"], "300639": ["Olfactory Signaling Pathway"], "300640": ["Olfactory Signaling Pathway"], "300643": ["Olfactory Signaling Pathway"], "300653": ["Post-translational modification: synthesis of GPI-anchored proteins"], "300664": ["ABC transporters in lipid homeostasis"], "300668": ["Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"], "300673": ["Formation of the beta-catenin:TCF transactivating complex", "Deactivation of the beta-catenin transactivating complex"], "300674": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "300675": ["Intraflagellar transport"], "300677": ["Formation of ATP by chemiosmotic coupling", "Cristae formation"], "300678": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "PD-1 signaling", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "300691": ["Methylation", "Nicotinamide salvaging"], "300711": ["DNA Damage/Telomere Stress Induced Senescence", "Regulation of HSF1-mediated heat shock response", "Autodegradation of the E3 ubiquitin ligase COP1", "HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Sensing of DNA Double Strand Breaks", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Nonhomologous End-Joining (NHEJ)", "Homologous DNA Pairing and Strand Exchange", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Regulation of TP53 Degradation", "G2/M DNA damage checkpoint", "Stabilization of p53"], "300721": ["HSP90 chaperone cycle for steroid hormone receptors (SHR)"], "300723": ["Lysine catabolism"], "300724": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "300726": ["Respiratory electron transport"], "300732": ["The NLRP3 inflammasome"], "300741": ["Synthesis of GDP-mannose"], "300754": ["BBSome-mediated cargo-targeting to cilium"], "300756": ["ISG15 antiviral mechanism"], "300757": ["Glycosphingolipid metabolism"], "300782": ["RNA polymerase II transcribes snRNA genes"], "300783": ["Synthesis of very long-chain fatty acyl-CoAs"], "300795": ["Termination of translesion DNA synthesis"], "300802": ["Regulated proteolysis of p75NTR", "NRIF signals cell death from the nucleus", "NOTCH3 Activation and Transmission of Signal to the Nucleus"], "300807": ["Nuclear Receptor transcription pathway", "SUMOylation of intracellular receptors"], "300811": ["CDO in myogenesis"], "300813": ["SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Formation of Incision Complex in GG-NER", "Antigen processing: Ubiquitination & Proteasome degradation"], "300837": ["Formation of RNA Pol II elongation complex ", "Formation of the beta-catenin:TCF transactivating complex", "RNA Polymerase II Pre-transcription Events", "RNA Polymerase II Transcription Elongation", "E3 ubiquitin ligases ubiquitinate target proteins"], "300838": ["Striated Muscle Contraction"], "300849": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "300857": ["Neutrophil degranulation"], "300880": ["Anchoring of the basal body to the plasma membrane"], "300886": ["Metabolism of folate and pterines"], "300888": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "300901": ["Collagen biosynthesis and modifying enzymes"], "300913": ["Receptor-type tyrosine-protein phosphatases"], "300944": ["Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA"], "300947": ["G0 and Early G1", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Cyclin D associated events in G1", "Transcriptional Regulation by E2F6"], "300948": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "300950": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "300963": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "300968": ["Antigen processing: Ubiquitination & Proteasome degradation"], "300974": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "300980": ["RAF-independent MAPK1/3 activation", "ERKs are inactivated", "Negative regulation of MAPK pathway"], "300981": ["Aflatoxin activation and detoxification"], "300983": ["Cytosolic sulfonation of small molecules"], "300988": ["Platelet degranulation "], "300993": ["CS/DS degradation"], "300996": ["mRNA Splicing - Major Pathway"], "301000": ["ISG15 antiviral mechanism", "Termination of translesion DNA synthesis", "Antigen processing: Ubiquitination & Proteasome degradation"], "301010": ["Multifunctional anion exchangers"], "301012": ["Collagen degradation", "Extracellular matrix organization", "Collagen biosynthesis and modifying enzymes", "Assembly of collagen fibrils and other multimeric structures", "COPII-mediated vesicle transport", "Integrin cell surface interactions", "Anchoring fibril formation", "Laminin interactions", "Cargo concentration in the ER", "Collagen chain trimerization"], "301013": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "301014": ["Activation of ATR in response to replication stress", "HDR through Single Strand Annealing (SSA)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Fanconi Anemia Pathway"], "301020": ["RMTs methylate histone arginines", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "301024": ["Regulation of cholesterol biosynthesis by SREBP (SREBF)"], "301034": ["Neutrophil degranulation", "Metal sequestration by antimicrobial proteins", "Antimicrobial peptides"], "301042": ["Antigen processing: Ubiquitination & Proteasome degradation"], "301059": ["PIP3 activates AKT signaling", "RIP-mediated NFkB activation via ZBP1", "p75NTR recruits signalling complexes", "DEx/H-box helicases activate type I IFN and inflammatory cytokines production ", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Interleukin-1 signaling", "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "MyD88 dependent cascade initiated on endosome"], "301066": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "301076": ["Generic Transcription Pathway"], "301086": ["Chemokine receptors bind chemokines", "G alpha (q) signalling events"], "301088": ["G alpha (i) signalling events"], "301111": ["Stimuli-sensing channels"], "301112": ["Tight junction interactions"], "301118": ["Sphingolipid de novo biosynthesis"], "301119": ["Formation of RNA Pol II elongation complex ", "RNA Polymerase II Pre-transcription Events", "RNA Polymerase II Transcription Elongation"], "301120": ["Synthesis of very long-chain fatty acyl-CoAs"], "301123": ["Respiratory electron transport", "Complex I biogenesis"], "301128": ["HDMs demethylate histones", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Estrogen-dependent gene expression"], "301131": ["PI Metabolism"], "301133": ["TNFR2 non-canonical NF-kB pathway", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "301155": ["Sialic acid metabolism"], "301221": ["Molybdenum cofactor biosynthesis"], "301226": ["mRNA Editing: C to U Conversion", "Formation of the Editosome"], "301227": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "DAP12 interactions", "DAP12 signaling", "Other semaphorin interactions"], "301229": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "DAP12 interactions"], "301233": ["Inactivation, recovery and regulation of the phototransduction cascade"], "301240": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "301246": ["B-WICH complex positively regulates rRNA expression", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase I Transcription Termination", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "301249": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "301250": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "301252": ["Regulation of actin dynamics for phagocytic cup formation", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "HSF1 activation", "Attenuation phase", "HSF1-dependent transactivation", "Sema3A PAK dependent Axon repulsion", "Neutrophil degranulation", "The NLRP3 inflammasome", "The role of GTSE1 in G2/M progression after G2 checkpoint", "Aryl hydrocarbon receptor signalling", "ESR-mediated signaling", "Estrogen-dependent gene expression"], "301261": ["Neutrophil degranulation"], "301264": ["Synthesis of bile acids and bile salts via 24-hydroxycholesterol", "Endogenous sterols"], "301265": ["Synthesis, secretion, and deacylation of Ghrelin"], "301284": ["Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "Activation of the TFAP2 (AP-2) family of transcription factors"], "301285": ["Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "Activation of the TFAP2 (AP-2) family of transcription factors"], "301289": ["Interleukin-17 signaling"], "301323": ["Inhibition of replication initiation of damaged DNA by RB1/E2F1", "Polymerase switching on the C-strand of the telomere", "Telomere C-strand synthesis initiation", "DNA replication initiation", "Activation of the pre-replicative complex", "Polymerase switching", "Removal of the Flap Intermediate", "Processive synthesis on the lagging strand"], "301334": ["NRAGE signals death through JNK", "Rho GTPase cycle"], "301352": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "301363": ["Oxidative Stress Induced Senescence"], "301365": ["Interleukin-18 signaling"], "301371": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "301372": ["G alpha (s) signalling events"], "301384": ["Branched-chain amino acid catabolism"], "301416": ["Respiratory electron transport"], "301418": ["Processing of SMDT1"], "301427": ["Respiratory electron transport", "Complex I biogenesis"], "301430": ["Activation of ATR in response to replication stress", "Assembly of the ORC complex at the origin of replication", "CDC6 association with the ORC:origin complex", "CDT1 association with the CDC6:ORC:origin complex", "Assembly of the pre-replicative complex", "Orc1 removal from chromatin", "Activation of the pre-replicative complex"], "301432": ["mRNA Splicing - Major Pathway"], "301442": ["SUMO is conjugated to E1 (UBA2:SAE1)", "SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "SUMO is proteolytically processed", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of transcription factors", "SUMOylation of ubiquitinylation proteins", "SUMOylation of transcription cofactors", "SUMOylation of SUMOylation proteins", "SUMOylation of intracellular receptors", "SUMOylation of chromatin organization proteins", "SUMOylation of RNA binding proteins", "SUMOylation of DNA replication proteins", "SUMOylation of DNA methylation proteins", "SUMOylation of immune response proteins", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Formation of Incision Complex in GG-NER", "G2/M DNA damage checkpoint", "Regulation of IFNG signaling", "Negative regulation of activity of TFAP2 (AP-2) family transcription factors"], "301458": ["Respiratory electron transport", "Complex I biogenesis"], "301460": ["LGI-ADAM interactions"], "301511": ["Regulation of actin dynamics for phagocytic cup formation", "EPHB-mediated forward signaling", "RHO GTPases Activate WASPs and WAVEs", "Clathrin-mediated endocytosis"], "301513": ["Deadenylation of mRNA", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "301515": ["Antigen processing: Ubiquitination & Proteasome degradation"], "301518": ["Macroautophagy", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Regulation of TP53 Activity through Phosphorylation"], "301525": ["Glycosphingolipid metabolism"], "301535": ["Neutrophil degranulation"], "301543": ["Sphingolipid de novo biosynthesis"], "301552": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "301555": ["Degradation of DVL", "Hedgehog 'on' state", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "301574": ["Energy dependent regulation of mTOR by LKB1-AMPK", "Neutrophil degranulation"], "301610": ["Olfactory Signaling Pathway"], "301622": ["Interconversion of nucleotide di- and triphosphates"], "301624": ["Interconversion of 2-oxoglutarate and 2-hydroxyglutarate"], "301626": ["PD-1 signaling"], "301674": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "301701": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "301737": ["Signaling by SCF-KIT"], "301887": ["Adherens junctions interactions"], "301965": ["Telomere Extension By Telomerase", "Formation of the beta-catenin:TCF transactivating complex"], "302027": ["Olfactory Signaling Pathway"], "302045": ["Olfactory Signaling Pathway"], "302288": ["Neddylation"], "302302": ["Chondroitin sulfate biosynthesis"], "302327": ["Generic Transcription Pathway"], "302366": ["Transcriptional Regulation by E2F6"], "302378": ["G alpha (q) signalling events", "P2Y receptors"], "302415": ["AKT phosphorylates targets in the nucleus", "Ub-specific processing proteases", "Regulation of localization of FOXO transcription factors", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "FOXO-mediated transcription of cell cycle genes"], "302422": ["Vitamin B5 (pantothenate) metabolism", "Transport of vitamins, nucleosides, and related molecules", "Ion influx/efflux at host-pathogen interface", "Ion transport by P-type ATPases"], "302424": ["TNFs bind their physiological receptors"], "302425": ["Acyl chain remodeling of DAG and TAG", "The retinoid cycle in cones (daylight vision)", "Wax biosynthesis"], "302488": ["Ub-specific processing proteases"], "302489": ["HS-GAG biosynthesis"], "302495": ["Neutrophil degranulation"], "302499": ["O-linked glycosylation of mucins"], "302502": ["Recognition of DNA damage by PCNA-containing replication complex", "DNA Damage Recognition in GG-NER", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Neddylation"], "302526": ["Metabolism of Angiotensinogen to Angiotensins", "Neutrophil degranulation"], "302536": ["Golgi Associated Vesicle Biogenesis", "Neutrophil degranulation", "Iron uptake and transport"], "302552": ["TBC/RABGAPs"], "302553": ["PKMTs methylate histone lysines", "SIRT1 negatively regulates rRNA expression"], "302557": ["mRNA Splicing - Major Pathway"], "302559": ["Macroautophagy"], "302619": ["Amine ligand-binding receptors", "G alpha (q) signalling events"], "302640": ["Mitochondrial Fatty Acid Beta-Oxidation"], "302642": ["Interconversion of polyamines"], "302661": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Hedgehog 'off' state", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "302666": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "302669": ["Reversible hydration of carbon dioxide"], "302670": ["mRNA Splicing - Minor Pathway"], "302671": ["MHC class II antigen presentation", "Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis"], "302697": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "302705": ["ATF6 (ATF6-alpha) activates chaperones"], "302711": ["Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)"], "302783": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Deposition of new CENPA-containing nucleosomes at the centromere", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "302813": ["Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)"], "302819": ["Rho GTPase cycle"], "302855": ["mRNA Splicing - Major Pathway"], "302879": ["mRNA Splicing - Major Pathway"], "302890": ["Neutrophil degranulation"], "302915": ["Synthesis of GDP-mannose"], "302931": ["Protein methylation"], "302934": ["Formation of the cornified envelope", "Butyrophilin (BTN) family interactions"], "302935": ["Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "302938": ["Antigen processing: Ubiquitination & Proteasome degradation"], "302950": ["PKA activation", "Adenylate cyclase activating pathway", "Adenylate cyclase inhibitory pathway", "G alpha (z) signalling events", "Hedgehog 'off' state"], "302954": ["Olfactory Signaling Pathway"], "302958": ["Olfactory Signaling Pathway"], "302972": ["Synthesis of UDP-N-acetyl-glucosamine"], "302973": ["ABC transporters in lipid homeostasis", "Surfactant metabolism"], "302976": ["RHO GTPases Activate NADPH Oxidases"], "302980": ["Citric acid cycle (TCA cycle)"], "302981": ["Neddylation"], "302987": ["Antigen processing: Ubiquitination & Proteasome degradation"], "303000": ["Degradation of the extracellular matrix"], "303016": ["CREB3 factors activate genes"], "303024": ["Activation of NF-kappaB in B cells", "Downstream TCR signaling", "Regulation of PLK1 Activity at G2/M Transition", "FCERI mediated NF-kB activation", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "NIK-->noncanonical NF-kB signaling", "MAP3K8 (TPL2)-dependent MAPK1/3 activation", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "303037": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "303039": ["Signaling by Hippo"], "303056": ["Ion transport by P-type ATPases"], "303057": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA 3'-end processing"], "303068": ["Invadopodia formation"], "303070": ["Miscellaneous transport and binding events"], "303073": ["Regulation of actin dynamics for phagocytic cup formation", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate WASPs and WAVEs"], "303088": ["Antigen processing: Ubiquitination & Proteasome degradation"], "303100": ["N-Glycan antennae elongation"], "303101": ["NOTCH1 Intracellular Domain Regulates Transcription", "NOTCH2 intracellular domain regulates transcription", "Notch-HLH transcription pathway", "RUNX3 regulates NOTCH signaling"], "303113": ["HATs acetylate histones"], "303132": ["Formation of RNA Pol II elongation complex ", "RNA Polymerase II Pre-transcription Events", "RNA Polymerase II Transcription Elongation"], "303164": ["Generic Transcription Pathway"], "303179": ["Interconversion of nucleotide di- and triphosphates"], "303180": ["Neutrophil degranulation"], "303181": ["TCF dependent signaling in response to WNT", "WNT ligand biogenesis and trafficking", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Regulation of FZD by ubiquitination"], "303193": ["Reversal of alkylation damage by DNA dioxygenases"], "303200": ["Oxidative Stress Induced Senescence", "activated TAK1 mediates p38 MAPK activation"], "303201": ["Ub-specific processing proteases"], "303205": ["Cellular hexose transport"], "303212": ["Generic Transcription Pathway"], "303218": ["HS-GAG biosynthesis"], "303222": ["Rho GTPase cycle"], "303226": ["Generic Transcription Pathway"], "303244": ["Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"], "303245": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "303251": ["WNT mediated activation of DVL", "Signaling by Hippo", "PCP/CE pathway", "Asymmetric localization of PCP proteins", "Degradation of DVL", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "WNT5A-dependent internalization of FZD4", "RHO GTPases Activate Formins", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "303259": ["Oxidative Stress Induced Senescence"], "303272": ["Lysine catabolism", "Peroxisomal protein import"], "303277": ["Attachment of GPI anchor to uPAR"], "303281": ["Formation of RNA Pol II elongation complex ", "RNA Polymerase II Pre-transcription Events", "RNA Polymerase II Transcription Elongation"], "303296": ["Olfactory Signaling Pathway"], "303298": ["Rap1 signalling"], "303306": ["Serine biosynthesis"], "303311": ["Post-translational modification: synthesis of GPI-anchored proteins"], "303333": ["Metabolism of folate and pterines", "Iron uptake and transport"], "303336": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "303351": ["Rho GTPase cycle", "Ub-specific processing proteases"], "303353": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "Neutrophil degranulation", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "303369": ["Resolution of AP sites via the single-nucleotide replacement pathway", "APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "HDR through MMEJ (alt-NHEJ)", "Gap-filling DNA repair synthesis and ligation in TC-NER"], "303375": ["HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange", "Presynaptic phase of homologous DNA pairing and strand exchange"], "303412": ["Regulation of FZD by ubiquitination"], "303413": ["Neutrophil degranulation", "Events associated with phagocytolytic activity of PMN cells"], "303414": ["Neutrophil degranulation"], "303478": ["Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Antigen processing: Ubiquitination & Proteasome degradation"], "303497": ["Synthesis of bile acids and bile salts"], "303514": ["HATs acetylate histones"], "303519": ["Keratinization", "Formation of the cornified envelope"], "303528": ["Keratinization", "Formation of the cornified envelope"], "303530": ["Keratinization", "Formation of the cornified envelope"], "303536": ["Regulation of HSF1-mediated heat shock response"], "303539": ["NOTCH1 Intracellular Domain Regulates Transcription", "Notch-HLH transcription pathway", "B-WICH complex positively regulates rRNA expression", "Ub-specific processing proteases", "RUNX3 regulates NOTCH signaling"], "303542": ["Neutrophil degranulation"], "303563": ["Urea cycle"], "303565": ["Gluconeogenesis"], "303575": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "303577": ["Peroxisomal lipid metabolism"], "303583": ["Rho GTPase cycle"], "303586": ["WNT ligand biogenesis and trafficking"], "303602": ["Neddylation"], "303604": ["Interleukin-1 signaling"], "303607": ["mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "303630": ["Macroautophagy"], "303631": ["Glycosphingolipid metabolism", "The activation of arylsulfatases"], "303634": ["NRAGE signals death through JNK", "Rho GTPase cycle", "G alpha (12/13) signalling events", "Thromboxane signalling through TP receptor", "Thrombin signalling through proteinase activated receptors (PARs)"], "303635": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "303639": ["ABC transporters in lipid homeostasis"], "303652": ["COPI-mediated anterograde transport", "Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network"], "303659": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "303673": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "303676": ["Vitamin B1 (thiamin) metabolism"], "303685": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "303687": ["Formation of the cornified envelope"], "303692": ["Sialic acid metabolism", "Termination of O-glycan biosynthesis"], "303702": ["N-glycan trimming in the ER and Calnexin/Calreticulin cycle"], "303730": ["Oxidative Stress Induced Senescence", "SUMOylation of transcription cofactors", "SUMOylation of chromatin organization proteins", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Regulation of PTEN gene transcription"], "303731": ["Oxidative Stress Induced Senescence", "SUMOylation of transcription cofactors", "SUMOylation of chromatin organization proteins", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Regulation of PTEN gene transcription"], "303734": ["TBC/RABGAPs"], "303742": ["Fanconi Anemia Pathway"], "303743": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "303746": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "303753": ["UCH proteinases"], "303754": ["RAB geranylgeranylation"], "303755": ["Gamma carboxylation, hypusine formation and arylsulfatase activation"], "303774": ["Post-transcriptional silencing by small RNAs"], "303782": ["Cell surface interactions at the vascular wall"], "303792": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "303796": ["HDL assembly"], "303831": ["ISG15 antiviral mechanism", "L13a-mediated translational silencing of Ceruloplasmin expression", "Deadenylation of mRNA", "Translation initiation complex formation", "Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "303835": ["Olfactory Signaling Pathway"], "303856": ["Ion transport by P-type ATPases"], "303874": ["SUMO is proteolytically processed"], "303886": ["MET activates RAS signaling", "O-linked glycosylation of mucins", "Termination of O-glycan biosynthesis"], "303903": ["Nicotinamide salvaging"], "303905": ["Nicotinamide salvaging"], "303915": ["Anchoring of the basal body to the plasma membrane"], "303918": ["RNA Polymerase II Pre-transcription Events", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "303922": ["Complex I biogenesis"], "303923": ["N-Glycan antennae elongation"], "303953": ["Glucuronidation"], "303963": ["Antigen processing: Ubiquitination & Proteasome degradation"], "303968": ["Hedgehog 'off' state", "Intraflagellar transport"], "304007": ["Anchoring of the basal body to the plasma membrane"], "304017": ["Pink/Parkin Mediated Mitophagy", "Ub-specific processing proteases"], "304021": ["Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "Collagen chain trimerization"], "304023": ["Keratan sulfate biosynthesis", "Sialic acid metabolism"], "304024": ["Heme biosynthesis"], "304037": ["ARL13B-mediated ciliary trafficking of INPP5E"], "304061": ["Interleukin-7 signaling", "Chromatin modifying enzymes"], "304063": ["Oncogene Induced Senescence"], "304078": ["Phase I - Functionalization of compounds"], "304091": ["Interleukin-10 signaling", "Interleukin-20 family signaling"], "304150": ["Ub-specific processing proteases"], "304157": ["SUMOylation of transcription cofactors", "Estrogen-dependent gene expression"], "304193": ["NRAGE signals death through JNK", "Rho GTPase cycle", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)"], "304195": ["G alpha (i) signalling events"], "304203": ["Miscellaneous transport and binding events"], "304204": ["RNA polymerase II transcribes snRNA genes", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "304208": ["Sphingolipid de novo biosynthesis"], "304218": ["Separation of Sister Chromatids", "Establishment of Sister Chromatid Cohesion", "Cohesin Loading onto Chromatin", "Resolution of Sister Chromatid Cohesion"], "304277": ["Cleavage of Growing Transcript in the Termination Region ", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "304284": ["Neutrophil degranulation"], "304290": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "304315": ["Stimuli-sensing channels"], "304318": ["Activation of SMO"], "304322": ["Chondroitin sulfate biosynthesis"], "304334": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "304343": ["DNA Damage Recognition in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Cargo recognition for clathrin-mediated endocytosis", "Neddylation"], "304344": ["Lysosome Vesicle Biogenesis"], "304349": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "304382": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "304429": ["Serine biosynthesis"], "304477": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "304485": ["ROS, RNS production in phagocytes", "Sperm Motility And Taxes", "Neutrophil degranulation"], "304486": ["Anchoring of the basal body to the plasma membrane"], "304490": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6", "Antigen processing: Ubiquitination & Proteasome degradation"], "304514": ["YAP1- and WWTR1 (TAZ)-stimulated gene expression"], "304528": ["Translesion synthesis by REV1", "Recognition of DNA damage by PCNA-containing replication complex", "Translesion Synthesis by POLH", "Polymerase switching on the C-strand of the telomere", "Activation of ATR in response to replication stress", "PCNA-Dependent Long Patch Base Excision Repair", "Translesion synthesis by POLK", "Translesion synthesis by POLI", "Termination of translesion DNA synthesis", "HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Polymerase switching"], "304539": ["Transcriptional activation of mitochondrial biogenesis"], "304543": ["Neutrophil degranulation"], "304545": ["OAS antiviral response"], "304555": ["RAB GEFs exchange GTP for GDP on RABs"], "304569": ["DNA Damage/Telomere Stress Induced Senescence"], "304571": ["O-linked glycosylation of mucins"], "304573": ["Recognition of DNA damage by PCNA-containing replication complex", "Telomere C-strand synthesis initiation", "PCNA-Dependent Long Patch Base Excision Repair", "Termination of translesion DNA synthesis", "HDR through Homologous Recombination (HRR)", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "DNA replication initiation", "Activation of the pre-replicative complex"], "304577": ["Cleavage of the damaged pyrimidine ", "Displacement of DNA glycosylase by APEX1"], "304579": ["Ub-specific processing proteases"], "304591": ["Activated NOTCH1 Transmits Signal to the Nucleus"], "304608": ["Degradation of the extracellular matrix"], "304610": ["Olfactory Signaling Pathway"], "304690": ["RUNX1 regulates transcription of genes involved in differentiation of keratinocytes"], "304692": ["Neutrophil degranulation"], "304714": ["RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape"], "304729": ["Hedgehog 'off' state", "Hedgehog 'on' state"], "304733": ["Neurexins and neuroligins"], "304758": ["Formation of RNA Pol II elongation complex ", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Transcription Elongation"], "304784": ["Multifunctional anion exchangers"], "304785": ["Cellular hexose transport"], "304794": ["Formation of the beta-catenin:TCF transactivating complex", "PKMTs methylate histone lysines", "Deactivation of the beta-catenin transactivating complex", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Neddylation"], "304798": ["Oxidative Stress Induced Senescence", "Oncogene Induced Senescence", "Ub-specific processing proteases", "Regulation of TP53 Activity through Phosphorylation", "Regulation of TP53 Degradation", "Stabilization of p53"], "304802": ["Degradation of the extracellular matrix"], "304813": ["Regulation of PLK1 Activity at G2/M Transition", "RHO GTPases activate PKNs", "RHO GTPases activate PAKs"], "304815": ["Pre-NOTCH Transcription and Translation"], "304816": ["Smooth Muscle Contraction"], "304822": ["Apoptotic cleavage of cell adhesion  proteins", "Neutrophil degranulation", "Keratinization", "Formation of the cornified envelope"], "304850": ["Oxidative Stress Induced Senescence", "SUMOylation of transcription cofactors", "SUMOylation of chromatin organization proteins", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Regulation of PTEN gene transcription", "Transcriptional Regulation by E2F6"], "304859": ["RIP-mediated NFkB activation via ZBP1", "DEx/H-box helicases activate type I IFN and inflammatory cytokines production ", "mRNA Splicing - Major Pathway"], "304860": ["Sialic acid metabolism"], "304883": ["Role of ABL in ROBO-SLIT signaling"], "304893": ["Regulation of RAS by GAPs"], "304913": ["ECM proteoglycans"], "304917": ["Intrinsic Pathway of Fibrin Clot Formation", "Common Pathway of Fibrin Clot Formation", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "304920": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "304944": ["Pyrimidine salvage"], "304951": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "304962": ["ATF6 (ATF6-alpha) activates chaperones"], "304966": ["Post-translational modification: synthesis of GPI-anchored proteins", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Neutrophil degranulation"], "304978": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "304983": ["Platelet degranulation "], "304985": ["Olfactory Signaling Pathway"], "304987": ["The AIM2 inflammasome"], "304988": ["Neutrophil degranulation"], "304991": ["Olfactory Signaling Pathway"], "305012": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "305021": ["Platelet degranulation "], "305025": ["Regulation of TP53 Activity through Association with Co-factors"], "305073": ["Recognition of DNA damage by PCNA-containing replication complex", "Neddylation"], "305076": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "305078": ["Degradation of the extracellular matrix", "Assembly of collagen fibrils and other multimeric structures", "Anchoring fibril formation", "Laminin interactions", "Type I hemidesmosome assembly", "MET activates PTK2 signaling"], "305081": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "305104": ["Collagen biosynthesis and modifying enzymes", "Signaling by PDGF", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "ECM proteoglycans", "NCAM1 interactions", "Collagen chain trimerization"], "305120": ["RNA polymerase II transcribes snRNA genes"], "305131": ["Miscellaneous transport and binding events"], "305135": ["Miscellaneous transport and binding events"], "305142": ["Iron uptake and transport"], "305149": ["Phosphate bond hydrolysis by NUDT proteins"], "305150": ["Lipid particle organization"], "305156": ["Rho GTPase cycle"], "305166": ["Synthesis of PA"], "305171": ["G0 and Early G1"], "305177": ["Methionine salvage pathway"], "305203": ["Negative regulation of MAPK pathway"], "305234": ["Neutrophil degranulation"], "305235": ["Post-translational modification: synthesis of GPI-anchored proteins"], "305236": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "305248": ["Metabolism of folate and pterines"], "305253": ["Collagen biosynthesis and modifying enzymes", "O-glycosylation of TSR domain-containing proteins"], "305258": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "305268": ["Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Antigen processing: Ubiquitination & Proteasome degradation"], "305288": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "305291": ["Androgen biosynthesis", "Synthesis of Dolichyl-phosphate"], "305311": ["FCERI mediated Ca+2 mobilization"], "305341": ["Rho GTPase cycle"], "305343": ["Separation of Sister Chromatids", "Establishment of Sister Chromatid Cohesion", "Cohesin Loading onto Chromatin", "Resolution of Sister Chromatid Cohesion"], "305348": ["Glyoxylate metabolism and glycine degradation"], "305349": ["Hedgehog 'off' state", "Intraflagellar transport"], "305351": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "305353": ["Regulation of TLR by endogenous ligand"], "305392": ["Condensation of Prometaphase Chromosomes"], "305419": ["Synthesis of PIPs at the ER membrane", "Synthesis of PIPs at the plasma membrane", "Synthesis of PIPs at the Golgi membrane"], "305420": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6", "Antigen processing: Ubiquitination & Proteasome degradation"], "305424": ["Neddylation", "Iron uptake and transport", "Antigen processing: Ubiquitination & Proteasome degradation"], "305451": ["MAP3K8 (TPL2)-dependent MAPK1/3 activation", "Ovarian tumor domain proteases"], "305455": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "RNA Polymerase II Transcription Elongation"], "305467": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "305479": ["mRNA Splicing - Major Pathway"], "305482": ["Macroautophagy", "Synthesis of PIPs at the plasma membrane"], "305509": ["PKA activation", "Adenylate cyclase activating pathway", "Adenylate cyclase inhibitory pathway", "G alpha (z) signalling events", "Hedgehog 'off' state"], "305539": ["Regulation of RAS by GAPs", "FGFRL1 modulation of FGFR1 signaling"], "305540": ["Amino acid transport across the plasma membrane"], "305549": ["Interleukin-1 signaling", "IRAK1 recruits IKK complex", "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation"], "305571": ["Keratan sulfate biosynthesis", "O-linked glycosylation of mucins"], "305581": ["E3 ubiquitin ligases ubiquitinate target proteins", "Peroxisomal protein import"], "305600": ["Fanconi Anemia Pathway"], "305604": ["Molecules associated with elastic fibres"], "305626": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "305679": ["Platelet degranulation ", "Smooth Muscle Contraction", "MAP2K and MAPK activation", "Neutrophil degranulation"], "305684": ["Sphingolipid de novo biosynthesis"], "305711": ["Olfactory Signaling Pathway"], "305714": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA 3'-end processing"], "305751": ["RIP-mediated NFkB activation via ZBP1", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "TRAF6 mediated NF-kB activation"], "305792": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "305795": ["Arachidonate production from DAG"], "305816": ["Synthesis of PA"], "305831": ["Macroautophagy"], "305835": ["Interleukin-1 signaling", "IRAK1 recruits IKK complex", "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation"], "305837": ["Regulation of TP53 Activity through Methylation"], "305841": ["Olfactory Signaling Pathway"], "305842": ["Antimicrobial peptides"], "305846": ["Zinc influx into cells by the SLC39 gene family"], "305851": ["Formation of RNA Pol II elongation complex ", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "Regulation of TP53 Activity through Phosphorylation", "RNA Polymerase II Transcription Elongation"], "305853": ["RAB geranylgeranylation"], "305880": ["Retinoid metabolism and transport"], "305882": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "305884": ["Apoptotic cleavage of cellular proteins"], "305889": ["Vitamin B1 (thiamin) metabolism"], "305895": ["Neddylation"], "305896": ["Interferon alpha/beta signaling"], "305918": ["Hedgehog 'off' state", "Intraflagellar transport"], "305922": ["Signaling by Hippo"], "305935": ["Synthesis of PIPs at the plasma membrane"], "305957": ["Cleavage of the damaged pyrimidine ", "APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway"], "305967": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "305987": ["Factors involved in megakaryocyte development and platelet production"], "306004": ["Rho GTPase cycle"], "306007": ["Regulation of HSF1-mediated heat shock response"], "306009": ["Zinc influx into cells by the SLC39 gene family"], "306012": ["RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "306013": ["LGI-ADAM interactions"], "306014": ["Olfactory Signaling Pathway"], "306073": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "306102": ["Regulation of PLK1 Activity at G2/M Transition"], "306129": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "306141": ["Spry regulation of FGF signaling", "EGFR downregulation"], "306147": ["Receptor-type tyrosine-protein phosphatases"], "306152": ["Receptor-type tyrosine-protein phosphatases"], "306204": ["ISG15 antiviral mechanism"], "306222": ["mRNA decay by 5' to 3' exoribonuclease", "mRNA Splicing - Major Pathway"], "306229": ["RAB GEFs exchange GTP for GDP on RABs"], "306247": ["Interleukin-17 signaling"], "306254": ["RMTs methylate histone arginines", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "306257": ["UCH proteinases", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"], "306260": ["Degradation of the extracellular matrix"], "306261": ["Formation of RNA Pol II elongation complex ", "RNA Polymerase II Pre-transcription Events", "RNA Polymerase II Transcription Elongation"], "306262": ["Biotin transport and metabolism"], "306274": ["B-WICH complex positively regulates rRNA expression", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "RNA Polymerase I Transcription Initiation"], "306279": ["Rho GTPase cycle"], "306307": ["G alpha (i) signalling events", "Opsins"], "306324": ["Neutrophil degranulation"], "306332": ["MHC class II antigen presentation", "Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis", "Neutrophil degranulation"], "306351": ["Sphingolipid de novo biosynthesis"], "306357": ["Rho GTPase cycle"], "306375": ["Chondroitin sulfate biosynthesis"], "306400": ["Rho GTPase cycle", "Sema4D mediated inhibition of cell attachment and migration", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases"], "306404": ["Activation of Matrix Metalloproteinases"], "306417": ["Antigen processing: Ubiquitination & Proteasome degradation"], "306460": ["Glycerophospholipid catabolism"], "306464": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Deposition of new CENPA-containing nucleosomes at the centromere", "Mitotic Prometaphase"], "306490": ["Synthesis of PIPs at the late endosome membrane"], "306492": ["Deadenylation of mRNA", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "306515": ["Synthesis, secretion, and deacylation of Ghrelin"], "306516": ["RNA Polymerase II Pre-transcription Events", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "306542": ["RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "306549": ["O-linked glycosylation"], "306570": ["Interaction between L1 and Ankyrins", "Neurofascin interactions", "COPI-mediated anterograde transport"], "306574": ["Urea cycle"], "306582": ["Synthesis of PA"], "306594": ["Condensation of Prophase Chromosomes"], "306599": ["Recruitment of mitotic centrosome proteins and complexes", "Recruitment of NuMA to mitotic centrosomes"], "306600": ["Neutrophil degranulation", "Ion transport by P-type ATPases"], "306608": ["Gamma-carboxylation of protein precursors", "Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "Removal of aminoterminal propeptides from gamma-carboxylated proteins"], "306636": ["EPH-Ephrin signaling", "EPHB-mediated forward signaling", "Ephrin signaling", "EPH-ephrin mediated repulsion of cells"], "306664": ["O-glycosylation of TSR domain-containing proteins"], "306665": ["RNA polymerase II transcribes snRNA genes"], "306734": ["HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange"], "306760": ["Neutrophil degranulation"], "306761": ["Intrinsic Pathway of Fibrin Clot Formation"], "306764": ["PKMTs methylate histone lysines"], "306782": ["WNT5A-dependent internalization of FZD2, FZD5 and ROR2"], "306792": ["G alpha (i) signalling events", "Lysosphingolipid and LPA receptors"], "306809": ["COPI-independent Golgi-to-ER retrograde traffic"], "306811": ["Stimuli-sensing channels"], "306817": ["B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors"], "306819": ["HDMs demethylate histones"], "306825": ["VLDLR internalisation and degradation", "Antigen processing: Ubiquitination & Proteasome degradation"], "306862": ["Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors", "Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "Activation of the TFAP2 (AP-2) family of transcription factors", "TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation"], "306866": ["Transport and synthesis of PAPS", "Transport of nucleotide sugars"], "306871": ["Apoptotic cleavage of cell adhesion  proteins", "Neutrophil degranulation", "Keratinization", "Formation of the cornified envelope"], "306886": ["TRP channels", "Regulation by c-FLIP", "RIPK1-mediated regulated necrosis", "CASP8 activity is inhibited", "TNFR1-induced proapoptotic signaling", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "Ub-specific processing proteases", "Ovarian tumor domain proteases", "Dimerization of procaspase-8", "TNF signaling"], "306941": ["Factors involved in megakaryocyte development and platelet production"], "306945": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HATs acetylate histones", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "E3 ubiquitin ligases ubiquitinate target proteins", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "306956": ["Butyrophilin (BTN) family interactions"], "306957": ["Butyrophilin (BTN) family interactions"], "306962": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Metalloprotease DUBs", "Deposition of new CENPA-containing nucleosomes at the centromere", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "306966": ["Generic Transcription Pathway"], "306969": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HATs acetylate histones", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "E3 ubiquitin ligases ubiquitinate target proteins", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "306970": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Metalloprotease DUBs", "Deposition of new CENPA-containing nucleosomes at the centromere", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "306974": ["Generic Transcription Pathway"], "306977": ["Generic Transcription Pathway"], "307016": ["Rho GTPase cycle"], "307039": ["Neutrophil degranulation", "COPI-independent Golgi-to-ER retrograde traffic", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "307081": ["Mitochondrial protein import"], "307092": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "RA biosynthesis pathway", "Retinoid metabolism and transport"], "307096": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "RA biosynthesis pathway", "Retinoid metabolism and transport"], "307098": ["NRAGE signals death through JNK", "Rho GTPase cycle"], "307126": ["Activation of ATR in response to replication stress", "Activation of the pre-replicative complex"], "307133": ["Regulation of HSF1-mediated heat shock response"], "307151": ["Oxidative Stress Induced Senescence", "SUMOylation of transcription cofactors", "SUMOylation of chromatin organization proteins", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Regulation of PTEN gene transcription", "Transcriptional Regulation by E2F6"], "307171": ["Integrin alphaIIb beta3 signaling", "GRB2:SOS provides linkage to MAPK signaling for Integrins ", "p130Cas linkage to MAPK signaling for integrins", "MAP2K and MAPK activation"], "307199": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "307200": ["Neddylation"], "307234": ["Voltage gated Potassium channels", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion"], "307270": ["Citric acid cycle (TCA cycle)"], "307271": ["Antigen processing: Ubiquitination & Proteasome degradation"], "307350": ["Processing of SMDT1"], "307351": ["Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Recruitment of NuMA to mitotic centrosomes", "Recycling pathway of L1", "Hedgehog 'off' state", "Cilium Assembly", "Intraflagellar transport", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "Carboxyterminal post-translational modifications of tubulin", "Kinesins"], "307382": ["COPII-mediated vesicle transport", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network"], "307396": ["Platelet degranulation "], "307398": ["NRAGE signals death through JNK", "Rho GTPase cycle"], "307401": ["Activation of the phototransduction cascade", "Inactivation, recovery and regulation of the phototransduction cascade", "Ca2+ pathway"], "307403": ["Other interleukin signaling"], "307404": ["Glycosphingolipid metabolism", "The activation of arylsulfatases"], "307410": ["mRNA Splicing - Major Pathway"], "307428": ["PI Metabolism"], "307459": ["Rho GTPase cycle"], "307485": ["RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "307503": ["Eukaryotic Translation Termination", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "307505": ["CDO in myogenesis", "Adherens junctions interactions", "VEGFR2 mediated vascular permeability", "RHO GTPases activate IQGAPs"], "307511": ["Polo-like kinase mediated events", "RHO GTPases activate PKNs", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "Cyclin A/B1/B2 associated events during G2/M transition", "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex"], "307524": ["Cleavage of Growing Transcript in the Termination Region ", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "307562": ["Apoptotic cleavage of cell adhesion  proteins", "Keratinization", "Formation of the cornified envelope"], "307563": ["Keratinization", "Formation of the cornified envelope"], "307639": ["Unwinding of DNA"], "307641": ["WNT mediated activation of DVL", "Signal transduction by L1", "Regulation of TP53 Activity through Phosphorylation", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Regulation of PTEN stability and activity"], "307724": ["Hedgehog 'off' state", "Anchoring of the basal body to the plasma membrane"], "307766": ["B-WICH complex positively regulates rRNA expression", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Deposition of new CENPA-containing nucleosomes at the centromere"], "307798": ["DNA Damage/Telomere Stress Induced Senescence"], "307799": ["TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "Tight junction interactions", "Asymmetric localization of PCP proteins"], "307805": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Deposition of new CENPA-containing nucleosomes at the centromere", "Mitotic Prometaphase"], "307810": ["FGFR2 alternative splicing"], "307811": ["Basigin interactions", "Amino acid transport across the plasma membrane"], "307821": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "Neutrophil degranulation", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "307833": ["Neutrophil degranulation"], "307838": ["O-linked glycosylation of mucins"], "307839": ["Generic Transcription Pathway"], "307842": ["Synthesis of PIPs at the Golgi membrane", "Synthesis of PIPs at the early endosome membrane", "Synthesis of PIPs at the late endosome membrane"], "307848": ["GDP-fucose biosynthesis"], "307852": ["Regulation of pyruvate dehydrogenase (PDH) complex"], "307855": ["Sphingolipid de novo biosynthesis"], "307858": ["Mitochondrial protein import"], "307859": ["Keratan sulfate biosynthesis"], "307861": ["DNA Damage/Telomere Stress Induced Senescence"], "307868": ["RAB GEFs exchange GTP for GDP on RABs"], "307893": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "307900": ["Voltage gated Potassium channels"], "307905": ["Termination of translesion DNA synthesis", "Ub-specific processing proteases"], "307947": ["RHO GTPases activate PKNs"], "307986": ["Platelet degranulation "], "307997": ["Regulation of HSF1-mediated heat shock response"], "308003": ["Vasopressin regulates renal water homeostasis via Aquaporins"], "308015": ["Stimuli-sensing channels"], "308016": ["Stimuli-sensing channels"], "308028": ["Cellular hexose transport"], "308051": ["TCF dependent signaling in response to WNT", "Degradation of AXIN", "Ub-specific processing proteases", "Regulation of PTEN stability and activity"], "308064": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "308069": ["Cation-coupled Chloride cotransporters"], "308097": ["Rho GTPase cycle"], "308118": ["G alpha (q) signalling events", "G alpha (i) signalling events", "G alpha (z) signalling events"], "308129": ["Thyroxine biosynthesis"], "308163": ["Beta defensins", "Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "308178": ["Endosomal Sorting Complex Required For Transport (ESCRT)"], "308190": ["Vitamins", "RA biosynthesis pathway"], "308201": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "308265": ["Signaling by Hippo"], "308267": ["NOD1/2 Signaling Pathway", "Downstream TCR signaling", "FCERI mediated NF-kB activation", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "TNFR1-induced NFkappaB signaling pathway", "CLEC7A (Dectin-1) signaling", "Interleukin-1 signaling", "IRAK2 mediated activation of TAK1 complex", "TRAF6-mediated induction of TAK1 complex within TLR4 complex", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"], "308282": ["E3 ubiquitin ligases ubiquitinate target proteins"], "308283": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "308311": ["Deadenylation of mRNA", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "308322": ["Generic Transcription Pathway"], "308326": ["Generic Transcription Pathway"], "308335": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing"], "308345": ["PKMTs methylate histone lysines"], "308362": ["Generic Transcription Pathway"], "308384": ["SUMO is conjugated to E1 (UBA2:SAE1)", "SUMO is transferred from E1 to E2 (UBE2I, UBC9)"], "308405": ["Ion homeostasis"], "308408": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (q) signalling events"], "308415": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "mRNA Capping", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase I Transcription Termination", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE"], "308416": ["Pink/Parkin Mediated Mitophagy"], "308417": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Adherens junctions interactions", "Nectin/Necl  trans heterodimerization"], "308420": ["Generic Transcription Pathway"], "308440": ["O-linked glycosylation of mucins"], "308441": ["mRNA decay by 3' to 5' exoribonuclease", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "KSRP (KHSRP) binds and destabilizes mRNA", "Major pathway of rRNA processing in the nucleolus and cytosol"], "308443": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Anchoring of the basal body to the plasma membrane", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "308445": ["Miscellaneous substrates", "Xenobiotics", "CYP2E1 reactions"], "308451": ["Synthesis of IP3 and IP4 in the cytosol"], "308457": ["Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"], "308458": ["NCAM signaling for neurite out-growth", "Interaction between L1 and Ankyrins", "RAF/MAP kinase cascade", "COPI-mediated anterograde transport"], "308476": ["Degradation of the extracellular matrix"], "308478": ["Regulation of RAS by GAPs"], "308482": ["Generic Transcription Pathway"], "308493": ["Regulation of TNFR1 signaling"], "308495": ["Synaptic adhesion-like molecules"], "308501": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "CD22 mediated BCR regulation", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "308503": ["Condensation of Prophase Chromosomes", "HuR (ELAVL1) binds and stabilizes mRNA"], "308511": ["Reactions specific to the complex N-glycan synthesis pathway"], "308516": ["RHO GTPases Activate Rhotekin and Rhophilins"], "308518": ["Peroxisomal lipid metabolism", "Peroxisomal protein import"], "308562": ["Formation of the cornified envelope"], "308564": ["Formation of the cornified envelope"], "308565": ["Formation of the cornified envelope"], "308571": ["Receptor-type tyrosine-protein phosphatases"], "308572": ["RHO GTPases activate PAKs"], "308576": ["APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway"], "308577": ["Hedgehog 'off' state"], "308578": ["Retrograde neurotrophin signalling", "MHC class II antigen presentation", "Trafficking of GluR2-containing AMPA receptors", "Recycling pathway of L1", "WNT5A-dependent internalization of FZD4", "WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "VLDLR internalisation and degradation", "LDL clearance"], "308582": ["YAP1- and WWTR1 (TAZ)-stimulated gene expression", "RUNX3 regulates YAP1-mediated transcription"], "308584": ["Synthesis of PIPs at the plasma membrane"], "308589": ["Sphingolipid de novo biosynthesis"], "308607": ["TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest"], "308632": ["Neutrophil degranulation"], "308650": ["mRNA Splicing - Major Pathway"], "308652": ["PAOs oxidise polyamines to amines", "Interconversion of polyamines"], "308653": ["Transport of Mature mRNA derived from an Intron-Containing Transcript"], "308663": ["Recruitment of mitotic centrosome proteins and complexes", "Recruitment of NuMA to mitotic centrosomes"], "308666": ["Regulation of actin dynamics for phagocytic cup formation", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate WASPs and WAVEs", "Neutrophil degranulation"], "308667": ["Miscellaneous transport and binding events"], "308669": ["SUMOylation of DNA damage response and repair proteins", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "G2/M DNA damage checkpoint", "Antigen processing: Ubiquitination & Proteasome degradation"], "308692": ["Beta-catenin phosphorylation cascade", "Disassembly of the destruction complex and recruitment of AXIN to the membrane"], "308716": ["Interleukin-20 family signaling"], "308718": ["Peroxisomal protein import"], "308757": ["Intra-Golgi traffic", "Reactions specific to the complex N-glycan synthesis pathway"], "308761": ["RHO GTPases activate CIT"], "308762": ["Carboxyterminal post-translational modifications of tubulin"], "308775": ["Antigen processing: Ubiquitination & Proteasome degradation"], "308776": ["G alpha (s) signalling events"], "308787": ["O-glycosylation of TSR domain-containing proteins"], "308800": ["Melanin biosynthesis"], "308807": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "308821": ["Intra-Golgi traffic", "RAB geranylgeranylation"], "308837": ["RNA polymerase II transcribes snRNA genes"], "308846": ["Macroautophagy"], "308868": ["Enzymatic degradation of dopamine by COMT"], "308869": ["Macroautophagy", "mTOR signalling", "mTORC1-mediated signalling", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Neutrophil degranulation", "Regulation of PTEN gene transcription"], "308873": ["Alpha-defensins"], "308875": ["GPVI-mediated activation cascade", "PIP3 activates AKT signaling", "Rho GTPase cycle", "RHO GTPases activate KTN1", "Neutrophil degranulation", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "308896": ["Ub-specific processing proteases"], "308899": ["cGMP effects"], "308901": ["Regulation of innate immune responses to cytosolic DNA", "Antigen processing: Ubiquitination & Proteasome degradation"], "308909": ["Glycosphingolipid metabolism"], "308911": ["SIRT1 negatively regulates rRNA expression"], "308918": ["Receptor-type tyrosine-protein phosphatases"], "308937": ["Polo-like kinase mediated events", "Cyclin E associated events during G1/S transition "], "308942": ["RAB GEFs exchange GTP for GDP on RABs"], "308944": ["RAB GEFs exchange GTP for GDP on RABs"], "308968": ["Antigen processing: Ubiquitination & Proteasome degradation"], "308976": ["HDMs demethylate histones"], "308977": ["Interleukin-21 signaling"], "308992": ["Generic Transcription Pathway"], "308995": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "Integrin cell surface interactions", "Neutrophil degranulation"], "308999": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "309002": ["Generic Transcription Pathway"], "309008": ["Synthesis of PIPs at the early endosome membrane"], "309010": ["COPII-mediated vesicle transport"], "309014": ["Role of phospholipids in phagocytosis"], "309035": ["Neddylation"], "309051": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "309070": ["Heme biosynthesis"], "309081": ["Regulation of actin dynamics for phagocytic cup formation", "DCC mediated attractive signaling", "VEGFA-VEGFR2 Pathway", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "Factors involved in megakaryocyte development and platelet production"], "309098": ["Recruitment of mitotic centrosome proteins and complexes", "Recruitment of NuMA to mitotic centrosomes"], "309111": ["Organic anion transporters"], "309126": ["Intraflagellar transport"], "309131": ["Organic cation transport"], "309135": ["Stimuli-sensing channels"], "309139": ["Stimuli-sensing channels"], "309140": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "309144": ["COPII-mediated vesicle transport"], "309147": ["Sphingolipid de novo biosynthesis", "Neutrophil degranulation"], "309153": ["Ub-specific processing proteases"], "309156": ["BBSome-mediated cargo-targeting to cilium"], "309157": ["Interleukin-1 signaling", "IRAK1 recruits IKK complex", "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation"], "309159": ["MHC class II antigen presentation", "RHO GTPases activate KTN1", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "309165": ["Activation of NF-kappaB in B cells", "RIP-mediated NFkB activation via ZBP1", "Regulated proteolysis of p75NTR", "Downstream TCR signaling", "NF-kB is activated and signals survival", "FCERI mediated NF-kB activation", "DEx/H-box helicases activate type I IFN and inflammatory cytokines production ", "PKMTs methylate histone lysines", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "Interleukin-1 processing", "SUMOylation of immune response proteins", "CLEC7A (Dectin-1) signaling", "CD209 (DC-SIGN) signaling", "Interleukin-1 signaling", "TRAF6 mediated NF-kB activation"], "309168": ["RAF activation"], "309175": ["MAPK6/MAPK4 signaling"], "309176": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "309179": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Degradation of beta-catenin by the destruction complex", "Beta-catenin phosphorylation cascade", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "CTLA4 inhibitory signaling", "RHO GTPases Activate Formins", "RAF activation", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Mitotic Prometaphase"], "309186": ["Platelet degranulation "], "309200": ["RNA polymerase II transcribes snRNA genes"], "309207": ["Arachidonate production from DAG"], "309212": ["Prostanoid ligand receptors", "G alpha (i) signalling events"], "309222": ["Olfactory Signaling Pathway"], "309242": ["Acetylcholine regulates insulin secretion", "G alpha (q) signalling events", "ADP signalling through P2Y purinoceptor 1", "Thromboxane signalling through TP receptor", "Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "Thrombin signalling through proteinase activated receptors (PARs)"], "309256": ["Fanconi Anemia Pathway"], "309262": ["Cholesterol biosynthesis"], "309280": ["Sema3A PAK dependent Axon repulsion", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "CRMPs in Sema3A signaling"], "309288": ["Nuclear Receptor transcription pathway"], "309295": ["Activation of NF-kappaB in B cells", "NOD1/2 Signaling Pathway", "RIP-mediated NFkB activation via ZBP1", "Downstream TCR signaling", "FCERI mediated NF-kB activation", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "SUMOylation of immune response proteins", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "CLEC7A (Dectin-1) signaling", "MAP3K8 (TPL2)-dependent MAPK1/3 activation", "Ub-specific processing proteases", "Ovarian tumor domain proteases", "Interleukin-1 signaling", "TRAF6 mediated NF-kB activation", "IRAK1 recruits IKK complex", "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation"], "309301": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "309304": ["PD-1 signaling"], "309306": ["Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network", "RAB GEFs exchange GTP for GDP on RABs"], "309312": ["Glycine degradation"], "309331": ["SUMOylation of transcription cofactors"], "309338": ["Cleavage of Growing Transcript in the Termination Region ", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "309349": ["Receptor-type tyrosine-protein phosphatases"], "309361": ["Activation of NF-kappaB in B cells", "NOD1/2 Signaling Pathway", "RIP-mediated NFkB activation via ZBP1", "AKT phosphorylates targets in the cytosol", "Downstream TCR signaling", "FCERI mediated NF-kB activation", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "NIK-->noncanonical NF-kB signaling", "MAP3K8 (TPL2)-dependent MAPK1/3 activation", "Interleukin-1 signaling", "TRAF6 mediated NF-kB activation", "IRAK1 recruits IKK complex", "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation"], "309380": ["Crosslinking of collagen fibrils"], "309390": ["Phosphate bond hydrolysis by NTPDase proteins"], "309391": ["Heme biosynthesis"], "309419": ["Synthesis of PIPs at the plasma membrane", "WNT mediated activation of DVL", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "309434": ["Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha"], "309440": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "309444": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "309447": ["RUNX1 regulates transcription of genes involved in differentiation of HSCs"], "309449": ["Synthesis of very long-chain fatty acyl-CoAs"], "309451": ["Clathrin derived vesicle budding", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "309452": ["RIP-mediated NFkB activation via ZBP1", "DEx/H-box helicases activate type I IFN and inflammatory cytokines production ", "PKMTs methylate histone lysines", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "Interleukin-1 processing", "SUMOylation of immune response proteins", "Dectin-1 mediated noncanonical NF-kB signaling", "NIK-->noncanonical NF-kB signaling", "TRAF6 mediated NF-kB activation"], "309453": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "309457": ["Transcriptional Regulation by E2F6"], "309458": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "309460": ["Invadopodia formation"], "309465": ["Glutathione conjugation", "Vitamin C (ascorbate) metabolism"], "309512": ["TCF dependent signaling in response to WNT", "Degradation of AXIN", "Ub-specific processing proteases", "Regulation of PTEN stability and activity"], "309523": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "309527": ["Synthesis of bile acids and bile salts"], "309528": ["Formation of the cornified envelope"], "309557": ["Neurexins and neuroligins"], "309584": ["ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "309591": ["Antigen processing: Ubiquitination & Proteasome degradation"], "309595": ["SUMOylation of DNA damage response and repair proteins", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "G2/M DNA damage checkpoint"], "309607": ["ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "309609": ["Platelet degranulation "], "309620": ["Butyrophilin (BTN) family interactions"], "309621": ["Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "MHC class II antigen presentation", "PD-1 signaling"], "309622": ["Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "MHC class II antigen presentation", "PD-1 signaling"], "309626": ["Oxidative Stress Induced Senescence", "SUMOylation of transcription cofactors", "SUMOylation of chromatin organization proteins", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Regulation of PTEN gene transcription", "Transcriptional Regulation by E2F6"], "309628": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "309638": ["RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "309647": ["Platelet degranulation ", "HATs acetylate histones", "Regulation of TP53 Activity through Acetylation"], "309651": ["mRNA Splicing - Major Pathway"], "309653": ["NRAGE signals death through JNK", "Rho GTPase cycle"], "309659": ["Post-translational modification: synthesis of GPI-anchored proteins"], "309678": ["COPII-mediated vesicle transport", "RAB GEFs exchange GTP for GDP on RABs"], "309684": ["Toll Like Receptor 4 (TLR4) Cascade", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "Integrin cell surface interactions", "Neutrophil degranulation"], "309686": ["O-glycosylation of TSR domain-containing proteins"], "309758": ["Antigen processing: Ubiquitination & Proteasome degradation"], "309790": ["HATs acetylate histones"], "309798": ["Retrograde transport at the Trans-Golgi-Network"], "309810": ["Cellular hexose transport"], "309812": ["Translesion synthesis by REV1", "Translesion synthesis by POLK", "Translesion synthesis by POLI"], "309855": ["Synthesis of PIPs at the Golgi membrane", "Synthesis of PIPs at the early endosome membrane", "Synthesis of PIPs at the late endosome membrane"], "309858": ["XBP1(S) activates chaperone genes"], "309918": ["RNA polymerase II transcribes snRNA genes"], "309922": ["Retrograde transport at the Trans-Golgi-Network"], "309957": ["CDO in myogenesis"], "309962": ["G alpha (s) signalling events"], "309969": ["Golgi Associated Vesicle Biogenesis"], "309995": ["SUMOylation of DNA damage response and repair proteins", "Nonhomologous End-Joining (NHEJ)"], "310019": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "310034": ["Activation of ATR in response to replication stress", "HDR through Single Strand Annealing (SSA)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange"], "310071": ["Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Neddylation"], "310074": ["Rho GTPase cycle"], "310091": ["Macroautophagy", "mTOR signalling", "mTORC1-mediated signalling", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Regulation of PTEN gene transcription"], "310097": ["Clathrin-mediated endocytosis"], "310131": ["PIP3 activates AKT signaling", "CD28 dependent PI3K/Akt signaling", "VEGFR2 mediated vascular permeability"], "310132": ["IL-6-type cytokine receptor ligand interactions"], "310152": ["Melanin biosynthesis"], "310155": ["Synthesis of PIPs at the early endosome membrane"], "310174": ["Adherens junctions interactions"], "310178": ["Regulation of actin dynamics for phagocytic cup formation"], "310194": ["HATs acetylate histones"], "310201": ["Phase I - Functionalization of compounds"], "310207": ["Other semaphorin interactions", "O-glycosylation of TSR domain-containing proteins"], "310218": ["Erythrocytes take up carbon dioxide and release oxygen", "Reversible hydration of carbon dioxide"], "310258": ["Oxidative Stress Induced Senescence", "SUMOylation of transcription cofactors", "SUMOylation of chromatin organization proteins", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Regulation of PTEN gene transcription", "Transcriptional Regulation by E2F6"], "310261": ["Hypusine synthesis from eIF5A-lysine"], "310303": ["Ca2+ activated K+ channels"], "310306": ["Ub-specific processing proteases", "Regulation of PTEN stability and activity"], "310326": ["Glycosphingolipid metabolism", "The activation of arylsulfatases"], "310327": ["Orexin and neuropeptides FF and QRFP bind to their respective receptors", "G alpha (q) signalling events"], "310344": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "310352": ["HATs acetylate histones"], "310363": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "310375": ["SUMOylation of transcription cofactors"], "310378": ["Citric acid cycle (TCA cycle)"], "310392": ["Basigin interactions", "Amino acid transport across the plasma membrane"], "310411": ["COPI-mediated anterograde transport", "Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network"], "310444": ["P2Y receptors", "G alpha (i) signalling events"], "310460": ["NRAGE signals death through JNK", "Rho GTPase cycle"], "310461": ["DEx/H-box helicases activate type I IFN and inflammatory cytokines production "], "310508": ["Glycosphingolipid metabolism"], "310519": ["Receptor-type tyrosine-protein phosphatases"], "310526": ["Intra-Golgi traffic"], "310533": ["RAF/MAP kinase cascade"], "310553": ["Beta defensins", "Regulation of TLR by endogenous ligand", "Neutrophil degranulation"], "310575": ["Formation of the cornified envelope"], "310611": ["Antimicrobial peptides"], "310612": ["Neutrophil degranulation"], "310614": ["Regulation of TP53 Activity through Acetylation", "RNA Polymerase I Transcription Initiation", "Regulation of PTEN gene transcription"], "310621": ["RHO GTPases activate IQGAPs"], "310625": ["Rhesus glycoproteins mediate ammonium transport."], "310630": ["Other semaphorin interactions"], "310632": ["RAB geranylgeranylation"], "310635": ["NRAGE signals death through JNK", "Rho GTPase cycle"], "310638": ["PKMTs methylate histone lysines"], "310643": ["EPH-Ephrin signaling", "EPHA-mediated growth cone collapse", "EPH-ephrin mediated repulsion of cells"], "310645": ["Cholesterol biosynthesis"], "310653": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "310655": ["TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)"], "310663": ["PI Metabolism"], "310667": ["Sphingolipid de novo biosynthesis"], "310670": ["O-glycosylation of TSR domain-containing proteins"], "310677": ["TNFR1-induced proapoptotic signaling", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "Ovarian tumor domain proteases"], "310678": ["Interleukin-7 signaling", "PRC2 methylates histones and DNA", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "Chromatin modifying enzymes", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression", "Factors involved in megakaryocyte development and platelet production"], "310683": ["Integrin cell surface interactions"], "310685": ["RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "310687": ["mRNA Splicing - Major Pathway"], "310688": ["VEGFA-VEGFR2 Pathway"], "310695": ["Nephrin family interactions"], "310710": ["ER-Phagosome pathway", "COPII-mediated vesicle transport", "Cargo concentration in the ER", "COPI-dependent Golgi-to-ER retrograde traffic"], "310720": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "310727": ["Generation of second messenger molecules"], "310732": ["Organic cation transport"], "310738": ["NGF processing", "Frs2-mediated activation", "ARMS-mediated activation", "Retrograde neurotrophin signalling", "TRKA activation by NGF", "PI3K/AKT activation", "NFG and proNGF binds to p75NTR", "NADE modulates death signalling", "NRIF signals cell death from the nucleus", "p75NTR recruits signalling complexes", "NF-kB is activated and signals survival", "Axonal growth stimulation"], "310745": ["Fanconi Anemia Pathway"], "310746": ["Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis"], "310769": ["RMTs methylate histone arginines"], "310772": ["RAB GEFs exchange GTP for GDP on RABs"], "310773": ["Synthesis of PC", "Synthesis of PE"], "310784": ["RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "310806": ["Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "MAPK6/MAPK4 signaling"], "310808": ["Transport of nucleotide sugars"], "310812": ["Lysosphingolipid and LPA receptors"], "310833": ["Rho GTPase cycle"], "310836": ["The canonical retinoid cycle in rods (twilight vision)", "ABC-family proteins mediated transport"], "310839": ["Clathrin-mediated endocytosis"], "310843": ["COPII-mediated vesicle transport", "MHC class II antigen presentation", "Cargo concentration in the ER", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "310848": ["Miscellaneous substrates", "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)"], "310849": ["Sphingolipid de novo biosynthesis"], "310864": ["Neutrophil degranulation", "Lysosomal oligosaccharide catabolism"], "310869": ["G alpha (i) signalling events", "Opsins"], "310900": ["Chylomicron assembly"], "310903": ["Abacavir metabolism", "RA biosynthesis pathway", "Ethanol oxidation"], "310914": ["Signaling by BMP"], "310935": ["GDP-fucose biosynthesis"], "310960": ["Ub-specific processing proteases", "Regulation of expression of SLITs and ROBOs"], "310999": ["NRAGE signals death through JNK", "Rho GTPase cycle"], "311030": ["EGFR downregulation", "Ub-specific processing proteases", "Negative regulation of MET activity", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "311039": ["O-linked glycosylation of mucins"], "311061": ["Elastic fibre formation", "Molecules associated with elastic fibres", "Integrin cell surface interactions", "ECM proteoglycans"], "311078": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "Metalloprotease DUBs", "Neutrophil degranulation", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "311111": ["NOSTRIN mediated eNOS trafficking"], "311123": ["Intraflagellar transport"], "311129": ["Synthesis of bile acids and bile salts"], "311144": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Cell surface interactions at the vascular wall", "Integrin cell surface interactions"], "311163": ["Adherens junctions interactions", "VEGFR2 mediated vascular permeability"], "311166": ["Cleavage of Growing Transcript in the Termination Region ", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "311169": ["Post-translational modification: synthesis of GPI-anchored proteins"], "311173": ["Olfactory Signaling Pathway"], "311175": ["Olfactory Signaling Pathway"], "311180": ["Olfactory Signaling Pathway"], "311187": ["Clathrin-mediated endocytosis"], "311193": ["Rho GTPase cycle"], "311202": ["O-linked glycosylation"], "311204": ["GDP-fucose biosynthesis", "Transport of nucleotide sugars"], "311215": ["HS-GAG biosynthesis"], "311245": ["PIP3 activates AKT signaling", "MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "NOD1/2 Signaling Pathway", "Regulated proteolysis of p75NTR", "Downstream TCR signaling", "NRIF signals cell death from the nucleus", "p75NTR recruits signalling complexes", "NF-kB is activated and signals survival", "FCERI mediated NF-kB activation", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "CLEC7A (Dectin-1) signaling", "Ub-specific processing proteases", "Ovarian tumor domain proteases", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Interleukin-1 signaling", "IRAK1 recruits IKK complex", "IRAK2 mediated activation of TAK1 complex", "TRAF6-mediated induction of TAK1 complex within TLR4 complex", "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "MyD88 dependent cascade initiated on endosome", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "MyD88 cascade initiated on plasma membrane"], "311254": ["Regulation of pyruvate dehydrogenase (PDH) complex", "Glyoxylate metabolism and glycine degradation", "Signaling by Retinoic Acid", "Pyruvate metabolism"], "311299": ["Regulation of the apoptosome activity"], "311324": ["Release of Hh-Np from the secreting cell"], "311327": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Deposition of new CENPA-containing nucleosomes at the centromere", "Mitotic Prometaphase"], "311331": ["MET Receptor Activation"], "311332": ["NOTCH2 Activation and Transmission of Signal to the Nucleus", "NOTCH3 Activation and Transmission of Signal to the Nucleus"], "311341": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PS", "Acyl chain remodelling of PE", "Acyl chain remodelling of PG", "Hydrolysis of LPC", "Synthesis of PA"], "311349": ["Anchoring of the basal body to the plasma membrane"], "311352": ["Purine salvage"], "311355": ["Synthesis of pyrophosphates in the cytosol"], "311358": ["Serine biosynthesis"], "311373": ["Antigen processing: Ubiquitination & Proteasome degradation"], "311384": ["Other semaphorin interactions"], "311387": ["Sodium/Calcium exchangers"], "311401": ["Regulation of TNFR1 signaling"], "311404": ["Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis"], "311406": ["RAF-independent MAPK1/3 activation", "Negative regulation of MAPK pathway"], "311412": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6", "Antigen processing: Ubiquitination & Proteasome degradation"], "311414": ["RNA polymerase II transcribes snRNA genes"], "311422": ["Purine catabolism"], "311426": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "311427": ["Regulation of HSF1-mediated heat shock response"], "311430": ["Negative regulators of DDX58/IFIH1 signaling"], "311446": ["Glyoxylate metabolism and glycine degradation", "Peroxisomal protein import"], "311478": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "311487": ["RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "311530": ["Sialic acid metabolism"], "311536": ["Vitamin B2 (riboflavin) metabolism"], "311546": ["Regulation of TP53 Activity through Phosphorylation", "AURKA Activation by TPX2"], "311548": ["Carboxyterminal post-translational modifications of tubulin"], "311558": ["Antimicrobial peptides"], "311559": ["Antimicrobial peptides"], "311569": ["Transcriptional activation of mitochondrial biogenesis", "Ethanol oxidation"], "311575": ["HATs acetylate histones", "Regulation of TP53 Degradation", "Regulation of TP53 Activity through Association with Co-factors", "Stabilization of p53"], "311580": ["Nucleobase catabolism"], "311591": ["RNA polymerase II transcribes snRNA genes"], "311617": ["Lipid particle organization"], "311622": ["Signaling by Hippo"], "311633": ["Neddylation"], "311655": ["Molybdenum cofactor biosynthesis"], "311658": ["Calcineurin activates NFAT", "FCERI mediated Ca+2 mobilization", "CLEC7A (Dectin-1) induces NFAT activation"], "311670": ["Cleavage of Growing Transcript in the Termination Region ", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "311676": ["Downregulation of TGF-beta receptor signaling"], "311716": ["Collagen biosynthesis and modifying enzymes", "Collagen chain trimerization"], "311764": ["Estrogen-dependent gene expression"], "311783": ["Interleukin-36 pathway"], "311786": ["Regulation by c-FLIP", "RIPK1-mediated regulated necrosis", "CASP8 activity is inhibited", "TNFR1-induced proapoptotic signaling", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "TNFR2 non-canonical NF-kB pathway", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "Ub-specific processing proteases", "Dimerization of procaspase-8", "TNF signaling"], "311793": ["RHO GTPases Activate NADPH Oxidases"], "311795": ["Platelet degranulation "], "311802": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "311807": ["Ub-specific processing proteases", "TFAP2 (AP-2) family regulates transcription of cell cycle factors", "Estrogen-dependent gene expression"], "311827": ["O-glycosylation of TSR domain-containing proteins"], "311833": ["Interconversion of nucleotide di- and triphosphates"], "311836": ["Post-translational modification: synthesis of GPI-anchored proteins"], "311839": ["Transport of fatty acids"], "311844": ["Amino acid synthesis and interconversion (transamination)", "Phenylalanine and tyrosine catabolism", "Tryptophan catabolism"], "311846": ["Miscellaneous transport and binding events"], "311847": ["Synthesis of Dolichyl-phosphate"], "311849": ["Beta-oxidation of pristanoyl-CoA", "Peroxisomal protein import"], "311854": ["Cargo recognition for clathrin-mediated endocytosis"], "311856": ["Ub-specific processing proteases"], "311860": ["Regulation of actin dynamics for phagocytic cup formation", "CDO in myogenesis", "Role of ABL in ROBO-SLIT signaling", "RHO GTPases Activate WASPs and WAVEs", "HDR through Single Strand Annealing (SSA)", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Cyclin D associated events in G1", "RUNX1 regulates transcription of genes involved in differentiation of HSCs"], "311864": ["Pyrimidine salvage"], "311865": ["Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "Neutrophil degranulation"], "311880": ["Clathrin-mediated endocytosis", "RAB GEFs exchange GTP for GDP on RABs"], "311881": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "311886": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "311903": ["Mitochondrial translation termination"], "311911": ["TBC/RABGAPs"], "311913": ["RAB GEFs exchange GTP for GDP on RABs"], "311919": ["Retrograde transport at the Trans-Golgi-Network"], "311952": ["O-linked glycosylation of mucins"], "312052": ["Transferrin endocytosis and recycling"], "312086": ["Synthesis of 5-eicosatetraenoic acids"], "312108": ["Rho GTPase cycle"], "312113": ["Rho GTPase cycle"], "312159": ["Platelet degranulation "], "312192": ["Bicarbonate transporters"], "312213": ["Sema3A PAK dependent Axon repulsion", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "CRMPs in Sema3A signaling"], "312227": ["Deadenylation of mRNA", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "312257": ["RAB GEFs exchange GTP for GDP on RABs"], "312279": ["EPH-Ephrin signaling", "EPHA-mediated growth cone collapse", "EPH-ephrin mediated repulsion of cells"], "312299": ["PRC2 methylates histones and DNA", "Oxidative Stress Induced Senescence", "PKMTs methylate histone lysines", "Regulation of PTEN gene transcription", "Transcriptional Regulation by E2F6"], "312303": ["Generic Transcription Pathway"], "312309": ["Generic Transcription Pathway"], "312316": ["Phase I - Functionalization of compounds", "Neutrophil degranulation"], "312317": ["Phase I - Functionalization of compounds", "Neutrophil degranulation"], "312373": ["Pyrimidine catabolism"], "312381": ["Branched-chain amino acid catabolism"], "312382": ["Iron uptake and transport"], "312440": ["HDMs demethylate histones"], "312451": ["Formation of the beta-catenin:TCF transactivating complex", "Deactivation of the beta-catenin transactivating complex", "Repression of WNT target genes", "RUNX3 regulates WNT signaling"], "312477": ["PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "RET signaling"], "312478": ["Crosslinking of collagen fibrils"], "312492": ["Smooth Muscle Contraction"], "312495": ["Vitamins"], "312510": ["FGFR2 alternative splicing"], "312538": ["Activation of ATR in response to replication stress", "Assembly of the pre-replicative complex", "Orc1 removal from chromatin", "Activation of the pre-replicative complex", "Switching of origins to a post-replicative state"], "312560": ["SUMOylation of DNA damage response and repair proteins", "DNA Damage Recognition in GG-NER", "Formation of Incision Complex in GG-NER"], "312562": ["Toll Like Receptor 9 (TLR9) Cascade", "Factors involved in megakaryocyte development and platelet production"], "312566": ["O-glycosylation of TSR domain-containing proteins"], "312634": ["Macroautophagy", "Synthesis of PIPs at the plasma membrane"], "312647": ["Macroautophagy", "Neutrophil degranulation", "Antigen processing: Ubiquitination & Proteasome degradation"], "312651": ["Hedgehog 'off' state", "Intraflagellar transport"], "312652": ["Other semaphorin interactions"], "312664": ["RAF/MAP kinase cascade"], "312670": ["AMPK inhibits chREBP transcriptional activation activity"], "312678": ["HDMs demethylate histones"], "312679": ["Interleukin-17 signaling"], "312688": ["ISG15 antiviral mechanism", "Ub-specific processing proteases", "Regulation of IFNA signaling"], "312689": ["Lysosome Vesicle Biogenesis", "Retrograde transport at the Trans-Golgi-Network", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "312690": ["Oxidative Stress Induced Senescence", "SUMOylation of transcription cofactors", "SUMOylation of chromatin organization proteins", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Regulation of PTEN gene transcription", "Transcriptional Regulation by E2F6"], "312694": ["Golgi Associated Vesicle Biogenesis", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "312701": ["Scavenging of heme from plasma"], "312703": ["E3 ubiquitin ligases ubiquitinate target proteins", "Peroxisomal protein import"], "312705": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Regulation of Complement cascade"], "312706": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "312710": ["DNA Damage Recognition in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Cargo recognition for clathrin-mediated endocytosis", "Neddylation"], "312711": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "312754": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Degradation of beta-catenin by the destruction complex", "Beta-catenin phosphorylation cascade", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "CTLA4 inhibitory signaling", "RHO GTPases Activate Formins", "RAF activation", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Mitotic Prometaphase"], "312781": ["Negative regulation of TCF-dependent signaling by WNT ligand antagonists", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "Regulation of FZD by ubiquitination"], "312800": ["PKMTs methylate histone lysines"], "312806": ["Post-translational modification: synthesis of GPI-anchored proteins"], "312826": ["Sialic acid metabolism"], "312828": ["Synthesis of PE"], "312855": ["Receptor-type tyrosine-protein phosphatases"], "312912": ["Regulation of PTEN stability and activity"], "312927": ["Macroautophagy"], "312936": ["Deactivation of the beta-catenin transactivating complex"], "312947": ["snRNP Assembly", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)"], "312952": ["Cytosolic sulfonation of small molecules"], "313017": ["Activation of BAD and translocation to mitochondria ", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "RHO GTPases activate PKNs", "TP53 Regulates Metabolic Genes", "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "Regulation of localization of FOXO transcription factors"], "313020": ["Neddylation"], "313027": ["Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"], "313038": ["Oxidative Stress Induced Senescence", "SUMOylation of transcription cofactors", "SUMOylation of chromatin organization proteins", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Regulation of PTEN gene transcription"], "313050": ["GPVI-mediated activation cascade", "PIP3 activates AKT signaling", "Signaling by SCF-KIT", "Regulation of KIT signaling", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "DAP12 signaling", "CD28 co-stimulation", "CD28 dependent PI3K/Akt signaling", "CD28 dependent Vav1 pathway", "CTLA4 inhibitory signaling", "PD-1 signaling", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Interleukin-2 signaling"], "313052": ["Neurexins and neuroligins"], "313057": ["Serine biosynthesis"], "313067": ["Anchoring of the basal body to the plasma membrane"], "313087": ["Glycerophospholipid biosynthesis", "Neutrophil degranulation"], "313098": ["Formation of Incision Complex in GG-NER"], "313101": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "313115": ["Antigen processing: Ubiquitination & Proteasome degradation"], "313121": ["NOD1/2 Signaling Pathway", "Downstream TCR signaling", "FCERI mediated NF-kB activation", "Ca2+ pathway", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "TNFR1-induced NFkappaB signaling pathway", "CLEC7A (Dectin-1) signaling", "Ub-specific processing proteases", "Interleukin-1 signaling", "IRAK2 mediated activation of TAK1 complex", "TRAF6-mediated induction of TAK1 complex within TLR4 complex", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"], "313126": ["Electric Transmission Across Gap Junctions", "Gap junction assembly"], "313131": ["mRNA Capping", "RNA Pol II CTD phosphorylation and interaction with CE"], "313139": ["Sialic acid metabolism", "Transport of nucleotide sugars"], "313163": ["Regulation of cholesterol biosynthesis by SREBP (SREBF)", "Transcriptional regulation by small RNAs"], "313167": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "313170": ["Anchoring of the basal body to the plasma membrane"], "313173": ["IL-6-type cytokine receptor ligand interactions"], "313210": ["HDL assembly"], "313216": ["E3 ubiquitin ligases ubiquitinate target proteins"], "313219": ["Generic Transcription Pathway"], "313231": ["Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"], "313233": ["O-linked glycosylation of mucins"], "313234": ["TBC/RABGAPs"], "313242": ["Neddylation"], "313245": ["B-WICH complex positively regulates rRNA expression", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase I Transcription Termination"], "313254": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "313262": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "313264": ["Regulation of innate immune responses to cytosolic DNA", "Antigen processing: Ubiquitination & Proteasome degradation"], "313304": ["Separation of Sister Chromatids", "Establishment of Sister Chromatid Cohesion", "Cohesin Loading onto Chromatin", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA damage response and repair proteins"], "313308": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA 3'-end processing"], "313339": ["Sphingolipid de novo biosynthesis"], "313348": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "313365": ["Intraflagellar transport"], "313387": ["Recognition of DNA damage by PCNA-containing replication complex", "Fanconi Anemia Pathway"], "313409": ["Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis", "Clathrin-mediated endocytosis"], "313421": ["Terminal pathway of complement", "Regulation of Complement cascade"], "313427": ["Ub-specific processing proteases"], "313438": ["Factors involved in megakaryocyte development and platelet production"], "313445": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "313449": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "313479": ["Activation of ATR in response to replication stress", "Assembly of the ORC complex at the origin of replication", "CDC6 association with the ORC:origin complex", "CDT1 association with the CDC6:ORC:origin complex", "Assembly of the pre-replicative complex", "Orc1 removal from chromatin", "Activation of the pre-replicative complex"], "313488": ["Post-translational modification: synthesis of GPI-anchored proteins"], "313493": ["Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network", "RAB GEFs exchange GTP for GDP on RABs"], "313494": ["Platelet degranulation ", "Integrin alphaIIb beta3 signaling", "GRB2:SOS provides linkage to MAPK signaling for Integrins ", "p130Cas linkage to MAPK signaling for integrins", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "Smooth Muscle Contraction", "MAP2K and MAPK activation"], "313495": ["Reversible hydration of carbon dioxide"], "313498": ["Other semaphorin interactions"], "313507": ["RUNX1 regulates transcription of genes involved in differentiation of HSCs"], "313520": ["Cobalamin (Cbl, vitamin B12) transport and metabolism"], "313525": ["Antigen processing: Ubiquitination & Proteasome degradation"], "313536": ["N-Glycan antennae elongation"], "313539": ["HDMs demethylate histones", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"], "313548": ["Generic Transcription Pathway"], "313560": ["Interconversion of nucleotide di- and triphosphates"], "313574": ["Pyrimidine catabolism"], "313581": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "313583": ["mRNA Splicing - Major Pathway"], "313589": ["Regulation of FZD by ubiquitination"], "313592": ["Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "Collagen chain trimerization"], "313593": ["MicroRNA (miRNA) biogenesis", "Small interfering RNA (siRNA) biogenesis", "Post-transcriptional silencing by small RNAs"], "313594": ["MicroRNA (miRNA) biogenesis", "Small interfering RNA (siRNA) biogenesis", "Post-transcriptional silencing by small RNAs", "Transcriptional regulation by small RNAs"], "313596": ["Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "Activation of the TFAP2 (AP-2) family of transcription factors"], "313611": ["Platelet homeostasis"], "313620": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing"], "313644": ["Rap1 signalling", "RET signaling"], "313648": ["Neutrophil degranulation"], "313662": ["Elastic fibre formation", "Molecules associated with elastic fibres"], "313689": ["The retinoid cycle in cones (daylight vision)", "RA biosynthesis pathway"], "313702": ["Translesion synthesis by REV1", "Translesion synthesis by POLK", "Translesion synthesis by POLI"], "313706": ["Metabolism of vitamin K"], "313707": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "313722": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "313743": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "313744": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "313749": ["Signaling by Hippo", "Anchoring of the basal body to the plasma membrane"], "313757": ["Signaling by BMP", "Downregulation of SMAD2/3:SMAD4 transcriptional activity"], "313770": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "313771": ["Glycosphingolipid metabolism"], "313782": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "313785": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Integrin cell surface interactions"], "313786": ["Mitochondrial iron-sulfur cluster biogenesis", "Pregnenolone biosynthesis", "Endogenous sterols", "Electron transport from NADPH to Ferredoxin"], "313806": ["Antigen processing: Ubiquitination & Proteasome degradation"], "313834": ["Sphingolipid de novo biosynthesis"], "313837": ["Neutrophil degranulation"], "313838": ["MAPK6/MAPK4 signaling"], "313845": ["SOS-mediated signalling", "SHC1 events in ERBB4 signaling", "Signaling by SCF-KIT", "Regulation of KIT signaling", "Signalling to RAS", "GRB2 events in EGFR signaling", "SHC1 events in EGFR signaling", "Downstream signal transduction", "NRAGE signals death through JNK", "Rho GTPase cycle", "GRB2 events in ERBB2 signaling", "Tie2 Signaling", "EGFR Transactivation by Gastrin", "DAP12 signaling", "SHC-related events triggered by IGF1R", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "GRB2:SOS provides linkage to MAPK signaling for Integrins ", "NCAM signaling for neurite out-growth", "SHC-mediated cascade:FGFR1", "FRS-mediated FGFR1 signaling", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "RAF/MAP kinase cascade", "Signal attenuation", "Insulin receptor signalling cascade", "MET activates RAS signaling", "RET signaling", "Interleukin-15 signaling", "Activated NTRK2 signals through FRS2 and FRS3", "Interleukin receptor SHC signaling", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "313874": ["Activation of RAS in B cells", "RAF/MAP kinase cascade"], "313878": ["O-linked glycosylation of mucins"], "313922": ["UCH proteinases"], "313929": ["Recycling of bile acids and salts", "Synthesis of bile acids and bile salts", "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "Endogenous sterols", "HATs acetylate histones", "SUMOylation of transcription cofactors", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)", "Estrogen-dependent gene expression"], "313934": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "313961": ["SUMOylation of DNA damage response and repair proteins"], "313977": ["Synthesis of PC", "Synthesis of PE", "Depolymerisation of the Nuclear Lamina", "Triglyceride biosynthesis"], "313978": ["Transcriptional Regulation by E2F6"], "313997": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PE"], "314013": ["RAB GEFs exchange GTP for GDP on RABs"], "314061": ["Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER"], "314075": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PE"], "314140": ["5-Phosphoribose 1-diphosphate biosynthesis"], "314196": ["Interconversion of 2-oxoglutarate and 2-hydroxyglutarate"], "314212": ["PCP/CE pathway", "RHO GTPases Activate Formins"], "314251": ["NCAM signaling for neurite out-growth", "Interaction between L1 and Ankyrins", "RAF/MAP kinase cascade", "COPI-mediated anterograde transport"], "314259": ["Tight junction interactions"], "314264": ["The canonical retinoid cycle in rods (twilight vision)"], "314273": ["Neddylation"], "314312": ["Phosphate bond hydrolysis by NTPDase proteins"], "314322": ["Oxidative Stress Induced Senescence", "FCERI mediated MAPK activation", "Activation of the AP-1 family of transcription factors", "Estrogen-dependent gene expression"], "314336": ["STING mediated induction of host immune responses", "Regulation of innate immune responses to cytosolic DNA"], "314349": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "314352": ["ABC-family proteins mediated transport", "Hedgehog ligand biogenesis", "ER Quality Control Compartment (ERQC)"], "314380": ["Nonhomologous End-Joining (NHEJ)"], "314384": ["ERK/MAPK targets", "CREB phosphorylation", "NCAM signaling for neurite out-growth", "CD209 (DC-SIGN) signaling"], "314386": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (q) signalling events"], "314393": ["Intraflagellar transport", "Intra-Golgi traffic"], "314396": ["Sodium/Calcium exchangers"], "314397": ["RAB GEFs exchange GTP for GDP on RABs"], "314401": ["Stimuli-sensing channels"], "314405": ["Ovarian tumor domain proteases"], "314416": ["Interconversion of nucleotide di- and triphosphates"], "314417": ["Cleavage of Growing Transcript in the Termination Region ", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "314432": ["Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Antigen processing: Ubiquitination & Proteasome degradation"], "314438": ["Sphingolipid de novo biosynthesis"], "314441": ["Amino acid transport across the plasma membrane"], "314453": ["Ub-specific processing proteases"], "314457": ["Neddylation"], "314459": ["Cobalamin (Cbl, vitamin B12) transport and metabolism", "HDL clearance"], "314465": ["Regulation of TP53 Activity through Association with Co-factors"], "314473": ["MHC class II antigen presentation", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "314480": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (q) signalling events"], "314523": ["Intraflagellar transport"], "314537": ["ABC-family proteins mediated transport"], "314545": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "314596": ["Regulation of RAS by GAPs"], "314612": ["Signalling to RAS", "VEGFA-VEGFR2 Pathway", "RAF/MAP kinase cascade"], "314613": ["Antigen processing: Ubiquitination & Proteasome degradation"], "314614": ["Lysosphingolipid and LPA receptors"], "314618": ["Rho GTPase cycle", "Neutrophil degranulation"], "314621": ["Energy dependent regulation of mTOR by LKB1-AMPK", "Regulation of TP53 Activity through Phosphorylation"], "314637": ["Zinc influx into cells by the SLC39 gene family"], "314638": ["CREB3 factors activate genes"], "314641": ["Synthesis of PIPs at the plasma membrane", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Clathrin-mediated endocytosis"], "314642": ["Autodegradation of Cdh1 by Cdh1:APC/C", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "Phosphorylation of Emi1", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6", "Cyclin A:Cdk2-associated events at S phase entry", "Antigen processing: Ubiquitination & Proteasome degradation"], "314644": ["Hypusine synthesis from eIF5A-lysine"], "314649": ["G alpha (i) signalling events", "Lysosphingolipid and LPA receptors"], "314655": ["O-glycosylation of TSR domain-containing proteins"], "314694": ["Chondroitin sulfate biosynthesis"], "314713": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "314756": ["TP53 Regulates Transcription of Caspase Activators and Caspases"], "314771": ["Keratan sulfate biosynthesis", "Keratan sulfate degradation"], "314787": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "Neutrophil degranulation", "AURKA Activation by TPX2"], "314799": ["Surfactant metabolism"], "314800": ["Synthesis of Ketone Bodies"], "314818": ["TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest"], "314824": ["Acyl chain remodelling of PS"], "314830": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "314843": ["Neutrophil degranulation"], "314847": ["Stimuli-sensing channels"], "314850": ["PI3K Cascade", "PIP3 activates AKT signaling", "Frs2-mediated activation", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "FRS-mediated FGFR2 signaling", "FRS-mediated FGFR3 signaling", "PI-3K cascade:FGFR3", "FRS-mediated FGFR4 signaling", "PI-3K cascade:FGFR4", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "RET signaling", "Activated NTRK2 signals through FRS2 and FRS3"], "314855": ["Post-translational modification: synthesis of GPI-anchored proteins"], "314856": ["AKT phosphorylates targets in the cytosol", "Oxidative Stress Induced Senescence", "Oncogene Induced Senescence", "SUMOylation of ubiquitinylation proteins", "Trafficking of AMPA receptors", "Ub-specific processing proteases", "Regulation of TP53 Activity through Phosphorylation", "Regulation of TP53 Degradation", "Stabilization of p53", "Regulation of RUNX3 expression and activity"], "314862": ["Regulation of TP53 Activity through Phosphorylation"], "314870": ["Interleukin-1 signaling"], "314903": ["Rho GTPase cycle"], "314904": ["G alpha (q) signalling events"], "314941": ["Retinoid metabolism and transport"], "314949": ["Separation of Sister Chromatids", "Establishment of Sister Chromatid Cohesion", "Cohesin Loading onto Chromatin", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA damage response and repair proteins"], "315000": ["ER Quality Control Compartment (ERQC)"], "315023": ["Metabolism of folate and pterines"], "315055": ["RAB GEFs exchange GTP for GDP on RABs"], "315075": ["Post-translational modification: synthesis of GPI-anchored proteins"], "315084": ["Neutrophil degranulation"], "315088": ["Generic Transcription Pathway"], "315093": ["Regulation of PTEN gene transcription"], "315108": ["Scavenging of heme from plasma", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "315134": ["Josephin domain DUBs"], "315139": ["NOD1/2 Signaling Pathway", "FCERI mediated NF-kB activation", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "TNFR1-induced NFkappaB signaling pathway", "CLEC7A (Dectin-1) signaling", "Ub-specific processing proteases", "Interleukin-1 signaling", "IRAK2 mediated activation of TAK1 complex", "TRAF6-mediated induction of TAK1 complex within TLR4 complex", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"], "315150": ["Purine ribonucleoside monophosphate biosynthesis"], "315151": ["SUMOylation of transcription cofactors", "RHO GTPases Activate Formins"], "315164": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Deposition of new CENPA-containing nucleosomes at the centromere", "Mitotic Prometaphase"], "315167": ["Respiratory electron transport", "Complex I biogenesis"], "315170": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA 3'-end processing"], "315173": ["Mitochondrial Fatty Acid Beta-Oxidation"], "315174": ["Degradation of the extracellular matrix"], "315189": ["PIP3 activates AKT signaling", "CD28 dependent PI3K/Akt signaling", "VEGFR2 mediated vascular permeability"], "315191": ["Molecules associated with elastic fibres"], "315210": ["HATs acetylate histones", "Regulation of TP53 Activity through Acetylation"], "315212": ["Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"], "315218": ["Assembly of active LPL and LIPC lipase complexes"], "315219": ["Pyrimidine catabolism"], "315222": ["Glycosphingolipid metabolism", "The activation of arylsulfatases", "Neutrophil degranulation"], "315259": ["Asymmetric localization of PCP proteins"], "315272": ["Stimuli-sensing channels", "Neutrophil degranulation"], "315287": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "315291": ["Formation of RNA Pol II elongation complex ", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Transcription Elongation", "Estrogen-dependent gene expression"], "315294": ["WNT ligand biogenesis and trafficking"], "315298": ["Rho GTPase cycle", "MHC class II antigen presentation", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "315305": ["CREB phosphorylation"], "315306": ["Neutrophil degranulation"], "315311": ["Bicarbonate transporters"], "315318": ["Keratinization", "Formation of the cornified envelope"], "315320": ["Keratinization", "Formation of the cornified envelope"], "315323": ["Keratinization", "Formation of the cornified envelope"], "315324": ["Keratinization", "Formation of the cornified envelope"], "315330": ["Separation of Sister Chromatids"], "315344": ["Cleavage of the damaged pyrimidine ", "Displacement of DNA glycosylase by APEX1"], "315345": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "315346": ["Elastic fibre formation", "Fibronectin matrix formation", "Cell surface interactions at the vascular wall", "Integrin cell surface interactions", "Signal transduction by L1"], "315348": ["Regulation of actin dynamics for phagocytic cup formation", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate WASPs and WAVEs", "Neutrophil degranulation"], "315388": ["Collagen degradation"], "315405": ["Neddylation"], "315422": ["Synthesis of PIPs at the ER membrane", "Synthesis of PIPs at the early endosome membrane", "Synthesis of PIPs at the late endosome membrane"], "315423": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "315427": ["TP53 Regulates Metabolic Genes"], "315435": ["Electric Transmission Across Gap Junctions", "The NLRP3 inflammasome"], "315439": ["Amino acid transport across the plasma membrane", "Tryptophan catabolism"], "315452": ["Olfactory Signaling Pathway"], "315508": ["Condensation of Prophase Chromosomes"], "315509": ["Cell surface interactions at the vascular wall", "Integrin cell surface interactions"], "315523": ["UCH proteinases", "DNA Damage Recognition in GG-NER"], "315530": ["Rho GTPase cycle"], "315564": ["Regulation of commissural axon pathfinding by SLIT and ROBO", "ROBO receptors bind AKAP5"], "315608": ["Antigen processing: Ubiquitination & Proteasome degradation"], "315609": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Phosphorylation of CD3 and TCR zeta chains", "Translocation of ZAP-70 to Immunological synapse", "Generation of second messenger molecules", "PD-1 signaling"], "315611": ["Phase 0 - rapid depolarisation"], "315615": ["DSCAM interactions"], "315639": ["Ub-specific processing proteases"], "315644": ["Retinoid metabolism and transport"], "315648": ["Inhibition of replication initiation of damaged DNA by RB1/E2F1", "Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "DARPP-32 events", "Degradation of beta-catenin by the destruction complex", "Beta-catenin phosphorylation cascade", "ERK/MAPK targets", "ERKs are inactivated", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "CTLA4 inhibitory signaling", "RHO GTPases Activate Formins", "RAF activation", "Regulation of TP53 Degradation", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Mitotic Prometaphase", "Cyclin D associated events in G1", "Cyclin A/B1/B2 associated events during G2/M transition"], "315668": ["Intra-Golgi traffic", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "315673": ["PI Metabolism"], "315691": ["Axonal growth inhibition (RHOA activation)"], "315697": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "315705": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "315707": ["GAB1 signalosome", "Phosphorylation of CD3 and TCR zeta chains", "Integrin alphaIIb beta3 signaling", "PD-1 signaling", "MAP2K and MAPK activation"], "315708": ["mRNA decay by 5' to 3' exoribonuclease"], "315711": ["Other semaphorin interactions"], "315714": ["Crosslinking of collagen fibrils"], "315722": ["Glycolysis"], "315723": ["UCH proteinases", "Neddylation"], "315745": ["Neddylation"], "315756": ["RAB GEFs exchange GTP for GDP on RABs"], "315764": ["Neutrophil degranulation"], "315807": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "315863": ["Antigen processing: Ubiquitination & Proteasome degradation"], "315879": ["O-glycosylation of TSR domain-containing proteins"], "315903": ["mRNA Splicing - Major Pathway"], "315911": ["Ub-specific processing proteases", "Ovarian tumor domain proteases"], "315912": ["Golgi Associated Vesicle Biogenesis"], "315949": ["Neutrophil degranulation"], "315958": ["Separation of Sister Chromatids", "Establishment of Sister Chromatid Cohesion", "Cohesin Loading onto Chromatin", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA damage response and repair proteins"], "315959": ["HATs acetylate histones"], "315973": ["Mitochondrial Fatty Acid Beta-Oxidation"], "315992": ["NTRK2 activates RAC1", "Factors involved in megakaryocyte development and platelet production"], "315994": ["p38MAPK events", "Oxidative Stress Induced Senescence", "VEGFA-VEGFR2 Pathway", "activated TAK1 mediates p38 MAPK activation"], "315999": ["RAB GEFs exchange GTP for GDP on RABs"], "316005": ["Antigen processing: Ubiquitination & Proteasome degradation"], "316009": ["G alpha (12/13) signalling events", "Sema4D mediated inhibition of cell attachment and migration", "Sema4D induced cell migration and growth-cone collapse"], "316013": ["PKMTs methylate histone lysines"], "316018": ["Olfactory Signaling Pathway"], "316019": ["Chemokine receptors bind chemokines"], "316033": ["Glycosphingolipid metabolism", "Sialic acid metabolism", "Neutrophil degranulation"], "316035": ["Neutrophil degranulation"], "316039": ["Acyl chain remodelling of PS"], "316062": ["Nicotinamide salvaging"], "316077": ["Phosphate bond hydrolysis by NTPDase proteins"], "316091": ["O-linked glycosylation"], "316098": ["mRNA decay by 3' to 5' exoribonuclease", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "KSRP (KHSRP) binds and destabilizes mRNA", "Major pathway of rRNA processing in the nucleolus and cytosol"], "316101": ["Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"], "316102": ["BBSome-mediated cargo-targeting to cilium"], "316108": ["snRNP Assembly"], "316123": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE", "Estrogen-dependent gene expression"], "316130": ["Triglyceride catabolism", "Retrograde transport at the Trans-Golgi-Network"], "316131": ["Neddylation"], "316137": ["Class B/2 (Secretin family receptors)"], "316164": ["Apoptotic cleavage of cellular proteins", "SUMOylation of chromatin organization proteins"], "316205": ["Synaptic adhesion-like molecules"], "316213": ["FRS-mediated FGFR1 signaling", "FRS-mediated FGFR2 signaling", "FRS-mediated FGFR3 signaling", "FRS-mediated FGFR4 signaling", "RAF/MAP kinase cascade"], "316216": ["RNA polymerase II transcribes snRNA genes"], "316218": ["Inactivation, recovery and regulation of the phototransduction cascade"], "316226": ["MHC class II antigen presentation", "RHO GTPases activate KTN1", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "316228": ["Neddylation"], "316231": ["ABC-family proteins mediated transport"], "316235": ["Translesion Synthesis by POLH", "Termination of translesion DNA synthesis", "HDR through Homologous Recombination (HRR)"], "316241": ["Activation of NF-kappaB in B cells"], "316259": ["G alpha (i) signalling events", "Opsins"], "316265": ["Gluconeogenesis"], "316273": ["Activation of ATR in response to replication stress", "Assembly of the pre-replicative complex", "Orc1 removal from chromatin", "Activation of the pre-replicative complex", "Switching of origins to a post-replicative state"], "316317": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "316325": ["HS-GAG biosynthesis"], "316328": ["HATs acetylate histones"], "316333": ["MHC class II antigen presentation", "Neutrophil degranulation"], "316342": ["Glyoxylate metabolism and glycine degradation"], "316344": ["Translesion synthesis by REV1", "Translesion synthesis by POLK", "Translesion synthesis by POLI", "Termination of translesion DNA synthesis"], "316369": ["Downstream signal transduction", "Nephrin family interactions", "Ephrin signaling", "VEGFA-VEGFR2 Pathway"], "316376": ["Synthesis of IP2, IP, and Ins in the cytosol"], "316395": ["Antigen processing: Ubiquitination & Proteasome degradation"], "316400": ["Attachment of GPI anchor to uPAR"], "316425": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "316440": ["UCH proteinases", "DNA Damage Recognition in GG-NER"], "316457": ["Synthesis of PIPs at the Golgi membrane", "Synthesis of PIPs at the early endosome membrane", "Synthesis of PIPs at the late endosome membrane"], "316516": ["Neutrophil degranulation"], "316519": ["ROS, RNS production in phagocytes", "Metal ion SLC transporters", "Neutrophil degranulation", "Ion influx/efflux at host-pathogen interface"], "316526": ["WNT ligand biogenesis and trafficking"], "316527": ["WNT ligand biogenesis and trafficking"], "316531": ["Platelet degranulation ", "Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Regulation of PLK1 Activity at G2/M Transition", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Recycling pathway of L1", "Hedgehog 'off' state", "Cilium Assembly", "Anchoring of the basal body to the plasma membrane", "Intraflagellar transport", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "AURKA Activation by TPX2", "Carboxyterminal post-translational modifications of tubulin", "Kinesins"], "316533": ["Chondroitin sulfate biosynthesis"], "316539": ["EPH-Ephrin signaling", "EPHA-mediated growth cone collapse", "EPH-ephrin mediated repulsion of cells"], "316559": ["Vitamin B1 (thiamin) metabolism"], "316575": ["Antigen processing: Ubiquitination & Proteasome degradation"], "316583": ["Keratan sulfate biosynthesis", "O-linked glycosylation of mucins"], "316602": ["Deposition of new CENPA-containing nucleosomes at the centromere"], "316628": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "316632": ["Respiratory electron transport", "Complex I biogenesis"], "316639": ["SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion"], "316640": ["Macroautophagy"], "316642": ["Glycosphingolipid metabolism", "Sialic acid metabolism"], "316737": ["Synthesis of PC", "Synthesis of PE", "Depolymerisation of the Nuclear Lamina", "Triglyceride biosynthesis"], "316742": ["Downregulation of SMAD2/3:SMAD4 transcriptional activity"], "316758": ["Laminin interactions", "MET activates PTK2 signaling"], "316794": ["Metalloprotease DUBs", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "G2/M DNA damage checkpoint"], "316810": ["RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter"], "316976": ["Protein methylation"], "317170": ["Sodium/Proton exchangers"], "317191": ["Platelet degranulation "], "317203": ["CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling", "RSK activation"], "317219": ["G alpha (q) signalling events", "P2Y receptors"], "317241": ["Antigen processing: Ubiquitination & Proteasome degradation"], "317252": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "317296": ["Synthesis of PIPs at the plasma membrane"], "317322": ["A tetrasaccharide linker sequence is required for GAG synthesis", "HS-GAG biosynthesis", "HS-GAG degradation", "Retinoid metabolism and transport"], "317335": ["Neutrophil degranulation"], "317371": ["Generation of second messenger molecules", "Regulation of actin dynamics for phagocytic cup formation", "RHO GTPases Activate WASPs and WAVEs"], "317381": ["Neddylation"], "317382": ["RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)"], "317385": ["mRNA Splicing - Major Pathway"], "317396": ["Cargo recognition for clathrin-mediated endocytosis"], "317399": ["B-WICH complex positively regulates rRNA expression", "Major pathway of rRNA processing in the nucleolus and cytosol"], "317409": ["Synthesis, secretion, and deacylation of Ghrelin"], "317420": ["Stimuli-sensing channels"], "317456": ["Acyl chain remodelling of PG"], "317464": ["HATs acetylate histones"], "317468": ["Trafficking and processing of endosomal TLR", "Toll Like Receptor 7/8 (TLR7/8) Cascade", "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "MyD88 dependent cascade initiated on endosome"], "317546": ["NOD1/2 Signaling Pathway", "FCERI mediated NF-kB activation", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "TNFR1-induced NFkappaB signaling pathway", "CLEC7A (Dectin-1) signaling", "Interleukin-1 signaling", "IRAK2 mediated activation of TAK1 complex", "TRAF6-mediated induction of TAK1 complex within TLR4 complex", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"], "317553": ["Receptor-type tyrosine-protein phosphatases", "Interleukin-38 signaling"], "317580": ["TBC/RABGAPs", "RAB geranylgeranylation"], "317589": ["Apoptotic cleavage of cellular proteins"], "317599": ["Ion transport by P-type ATPases"], "317630": ["Golgi Associated Vesicle Biogenesis"], "317646": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "317675": ["Serotonin and melatonin biosynthesis"], "317676": ["Role of LAT2/NTAL/LAB on calcium mobilization"], "319104": ["Amine ligand-binding receptors", "G alpha (s) signalling events"], "319107": ["Amine ligand-binding receptors", "G alpha (s) signalling events"], "319110": ["mRNA Splicing - Major Pathway"], "338443": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (s) signalling events"], "353218": ["TNFs bind their physiological receptors"], "353227": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "353229": ["Sphingolipid de novo biosynthesis"], "353231": ["Processing of SMDT1"], "353233": ["TNFR1-mediated ceramide production"], "353250": ["Hydroxycarboxylic acid-binding receptors", "Class A/1 (Rhodopsin-like receptors)", "G alpha (i) signalling events"], "353251": ["Post-translational modification: synthesis of GPI-anchored proteins"], "353252": ["The canonical retinoid cycle in rods (twilight vision)", "RA biosynthesis pathway"], "353253": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "353307": ["Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"], "359725": ["Fatty acyl-CoA biosynthesis"], "359726": ["OAS antiviral response", "Interferon alpha/beta signaling"], "359727": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "359728": ["RAB geranylgeranylation"], "360161": ["Activation of NIMA Kinases NEK9, NEK6, NEK7", "Nuclear Pore Complex (NPC) Disassembly"], "360202": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "360254": ["HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange", "Presynaptic phase of homologous DNA pairing and strand exchange"], "360268": ["Cytosolic sulfonation of small molecules"], "360272": ["Signaling by ROBO receptors", "Role of ABL in ROBO-SLIT signaling", "SLIT2:ROBO1 increases RHOA activity", "Regulation of expression of SLITs and ROBOs"], "360302": ["EGFR downregulation"], "360406": ["Receptor-type tyrosine-protein phosphatases", "Synaptic adhesion-like molecules"], "360426": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PE", "Role of phospholipids in phagocytosis", "COPI-independent Golgi-to-ER retrograde traffic"], "360457": ["Platelet degranulation ", "VEGF ligand-receptor interactions", "VEGF binds to VEGFR leading to receptor dimerization"], "360475": ["Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"], "360491": ["Antigen processing: Ubiquitination & Proteasome degradation"], "360504": ["Erythrocytes take up carbon dioxide and release oxygen", "Erythrocytes take up oxygen and release carbon dioxide", "Scavenging of heme from plasma"], "360511": ["Coenzyme A biosynthesis"], "360515": ["Golgi Associated Vesicle Biogenesis"], "360518": ["Synthesis of UDP-N-acetyl-glucosamine"], "360521": ["Synthesis of PIPs at the plasma membrane"], "360526": ["Collagen biosynthesis and modifying enzymes"], "360534": ["Antigen processing: Ubiquitination & Proteasome degradation"], "360539": ["Transport of bile salts and organic acids, metal ions and amine compounds"], "360540": ["Factors involved in megakaryocyte development and platelet production"], "360546": ["EPH-Ephrin signaling", "EPHB-mediated forward signaling", "Ephrin signaling", "EPH-ephrin mediated repulsion of cells"], "360548": ["TNFR2 non-canonical NF-kB pathway", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "360557": ["The NLRP1 inflammasome"], "360564": ["RHO GTPases Activate Rhotekin and Rhophilins"], "360573": ["RAF activation", "MAP2K and MAPK activation", "Negative regulation of MAPK pathway"], "360579": ["G alpha (q) signalling events", "G alpha (i) signalling events"], "360588": ["HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange"], "360589": ["RNA polymerase II transcribes snRNA genes"], "360592": ["Antigen processing: Ubiquitination & Proteasome degradation"], "360594": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "360600": ["CDO in myogenesis"], "360606": ["Basigin interactions", "Integrin cell surface interactions", "Laminin interactions", "MET activates PTK2 signaling"], "360611": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "360613": ["mRNA Splicing - Major Pathway"], "360616": ["DARPP-32 events"], "360618": ["Sphingolipid de novo biosynthesis", "Neutrophil degranulation"], "360620": ["Regulation of actin dynamics for phagocytic cup formation", "RHO GTPases Activate WASPs and WAVEs"], "360621": ["Activation of ATR in response to replication stress", "CDC6 association with the ORC:origin complex", "CDT1 association with the CDC6:ORC:origin complex", "Assembly of the pre-replicative complex", "Orc1 removal from chromatin", "Activation of the pre-replicative complex", "CDK-mediated phosphorylation and removal of Cdc6"], "360622": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "360623": ["Keratinization", "Formation of the cornified envelope"], "360626": ["Keratinization", "Formation of the cornified envelope"], "360629": ["mRNA decay by 3' to 5' exoribonuclease"], "360630": ["HS-GAG degradation"], "360635": ["MAPK6/MAPK4 signaling"], "360638": ["LGI-ADAM interactions"], "360640": ["CD28 dependent PI3K/Akt signaling", "Dectin-1 mediated noncanonical NF-kB signaling", "TNFR2 non-canonical NF-kB pathway", "NIK-->noncanonical NF-kB signaling", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "360643": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6", "Antigen processing: Ubiquitination & Proteasome degradation"], "360647": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Integrin cell surface interactions", "CD209 (DC-SIGN) signaling"], "360652": ["SDK interactions"], "360658": ["MET receptor recycling"], "360665": ["HDMs demethylate histones"], "360672": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "360678": ["Axonal growth inhibition (RHOA activation)", "Rho GTPase cycle", "Axonal growth stimulation"], "360682": ["Macroautophagy"], "360697": ["Interferon gamma signaling", "Regulation of IFNG signaling"], "360704": ["Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER"], "360709": ["COPII-mediated vesicle transport"], "360715": ["CDO in myogenesis", "Activation of SMO"], "360726": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA 3'-end processing"], "360733": ["Olfactory Signaling Pathway"], "360746": ["Basigin interactions"], "360748": ["Nonhomologous End-Joining (NHEJ)"], "360750": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "360764": ["Generic Transcription Pathway"], "360768": ["RAB GEFs exchange GTP for GDP on RABs"], "360776": ["Macroautophagy", "mTOR signalling", "mTORC1-mediated signalling", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Regulation of PTEN gene transcription"], "360777": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "360785": ["MHC class II antigen presentation", "Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis"], "360800": ["Glycosphingolipid metabolism", "The activation of arylsulfatases"], "360801": ["Downregulation of SMAD2/3:SMAD4 transcriptional activity", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)"], "360803": ["mRNA Splicing - Minor Pathway"], "360814": ["Regulation of RAS by GAPs"], "360816": ["Threonine catabolism"], "360819": ["Ub-specific processing proteases"], "360820": ["GAB1 signalosome", "VEGFA-VEGFR2 Pathway", "Smooth Muscle Contraction", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases"], "360826": ["Mitochondrial protein import", "Mitochondrial iron-sulfur cluster biogenesis"], "360827": ["Macroautophagy", "TBC/RABGAPs", "RAB GEFs exchange GTP for GDP on RABs", "Receptor Mediated Mitophagy"], "360828": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "360829": ["Initiation of Nuclear Envelope Reformation"], "360833": ["Sphingolipid de novo biosynthesis"], "360834": ["Endosomal Sorting Complex Required For Transport (ESCRT)"], "360838": ["Post-translational modification: synthesis of GPI-anchored proteins"], "360840": ["Rho GTPase cycle", "RHO GTPases Activate Formins"], "360843": ["Synthesis of PE"], "360845": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA 3'-end processing"], "360847": ["Fanconi Anemia Pathway", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes"], "360850": ["Activation of NIMA Kinases NEK9, NEK6, NEK7", "Nuclear Pore Complex (NPC) Disassembly"], "360853": ["UCH proteinases"], "360854": ["Regulation of actin dynamics for phagocytic cup formation", "EPHB-mediated forward signaling", "RHO GTPases Activate WASPs and WAVEs", "Neutrophil degranulation", "Clathrin-mediated endocytosis"], "360857": ["G alpha (q) signalling events", "G alpha (i) signalling events", "G alpha (z) signalling events"], "360860": ["Autodegradation of the E3 ubiquitin ligase COP1", "Neddylation"], "360882": ["Adherens junctions interactions", "Nectin/Necl  trans heterodimerization"], "360886": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "360891": ["Signaling by ROBO receptors"], "360896": ["Nuclear Receptor transcription pathway"], "360903": ["FGFRL1 modulation of FGFR1 signaling"], "360904": ["HS-GAG degradation"], "360905": ["PRC2 methylates histones and DNA"], "360908": ["Activation of ATR in response to replication stress", "Activation of the pre-replicative complex"], "360914": ["Neutrophil degranulation"], "360915": ["DNA Damage Recognition in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Cargo recognition for clathrin-mediated endocytosis", "Neddylation"], "360917": ["Deadenylation of mRNA", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "360918": ["Platelet degranulation ", "Common Pathway of Fibrin Clot Formation", "Cell surface interactions at the vascular wall", "Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "360920": ["Signaling by Hippo"], "360926": ["Antigen processing: Ubiquitination & Proteasome degradation"], "360928": ["Neddylation"], "360937": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane"], "360942": ["Platelet degranulation "], "360950": ["Platelet degranulation "], "360953": ["COPI-dependent Golgi-to-ER retrograde traffic"], "360956": ["TBC/RABGAPs"], "360968": ["TBC/RABGAPs"], "360972": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA 3'-end processing"], "360975": ["Glyoxylate metabolism and glycine degradation", "Lysine catabolism"], "360991": ["Initiation of Nuclear Envelope Reformation"], "360994": ["Glutathione synthesis and recycling"], "361005": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "361014": ["N-glycan trimming in the ER and Calnexin/Calreticulin cycle"], "361020": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "361029": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "RHO GTPases activate KTN1", "Post-translational protein phosphorylation"], "361034": ["NRAGE signals death through JNK", "Rho GTPase cycle"], "361035": ["Processing of Capped Intron-Containing Pre-mRNA"], "361037": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "361057": ["RNA polymerase II transcribes snRNA genes"], "361063": ["Phosphate bond hydrolysis by NTPDase proteins"], "361068": ["Phosphate bond hydrolysis by NUDT proteins"], "361069": ["Miscellaneous transport and binding events"], "361071": ["Citric acid cycle (TCA cycle)"], "361073": ["COPI-mediated anterograde transport", "Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network"], "361076": ["Effects of PIP2 hydrolysis"], "361084": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "361102": ["RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "361107": ["UCH proteinases", "DNA Damage Recognition in GG-NER"], "361109": ["mRNA decay by 5' to 3' exoribonuclease", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "361120": ["EGFR downregulation", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "361128": ["Nuclear Receptor transcription pathway"], "361171": ["Neutrophil degranulation"], "361176": ["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "361178": ["G0 and Early G1", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Cyclin D associated events in G1", "Transcriptional Regulation by E2F6"], "361181": ["Recognition of DNA damage by PCNA-containing replication complex", "DNA Damage Recognition in GG-NER", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Neddylation"], "361185": ["Nicotinamide salvaging"], "361187": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "361190": ["Ub-specific processing proteases"], "361195": ["MAPK6/MAPK4 signaling"], "361196": ["Platelet degranulation "], "361207": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "361208": ["Neutrophil degranulation", "RAB geranylgeranylation"], "361213": ["Sphingolipid de novo biosynthesis"], "361215": ["Branched-chain amino acid catabolism"], "361223": ["NRAGE signals death through JNK", "Rho GTPase cycle"], "361227": ["TBC/RABGAPs"], "361239": ["Phase I - Functionalization of compounds"], "361244": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "361251": ["Regulation of actin dynamics for phagocytic cup formation", "VEGFA-VEGFR2 Pathway", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases"], "361258": ["Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "361266": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "RA biosynthesis pathway", "Retinoid metabolism and transport"], "361268": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "361272": ["Glyoxylate metabolism and glycine degradation"], "361273": ["XBP1(S) activates chaperone genes"], "361274": ["Phosphate bond hydrolysis by NUDT proteins"], "361277": ["Mitochondrial Fatty Acid Beta-Oxidation"], "361286": ["Protein repair"], "361289": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Scavenging by Class A Receptors"], "361293": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "361300": ["Molybdenum cofactor biosynthesis"], "361308": ["MHC class II antigen presentation", "COPI-dependent Golgi-to-ER retrograde traffic", "Mitotic Telophase/Cytokinesis", "Kinesins"], "361319": ["Formation of the cornified envelope"], "361321": ["Macroautophagy", "Pink/Parkin Mediated Mitophagy", "Receptor Mediated Mitophagy"], "361323": ["Neddylation"], "361332": ["O-glycosylation of TSR domain-containing proteins"], "361338": ["Heme biosynthesis"], "361364": ["RET signaling"], "361365": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Transcriptional regulation by small RNAs", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE", "Estrogen-dependent gene expression"], "361368": ["O-linked glycosylation"], "361370": ["Neutrophil degranulation"], "361374": ["Regulation of TP53 Activity through Acetylation"], "361377": ["Glycogen breakdown (glycogenolysis)"], "361378": ["Neutrophil degranulation", "Lysosomal oligosaccharide catabolism"], "361381": ["Josephin domain DUBs", "DNA Damage Recognition in GG-NER", "Formation of Incision Complex in GG-NER"], "361384": ["Regulation of HSF1-mediated heat shock response", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Attenuation phase", "HSF1-dependent transactivation", "MAPK6/MAPK4 signaling"], "361385": ["Respiratory electron transport", "Complex I biogenesis"], "361389": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6", "Antigen processing: Ubiquitination & Proteasome degradation"], "361390": ["OAS antiviral response", "Interferon alpha/beta signaling"], "361391": ["RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "Transcriptional regulation by RUNX2", "RUNX1 regulates estrogen receptor mediated transcription", "Regulation of RUNX1 Expression and Activity", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "RUNX1 regulates transcription of genes involved in BCR signaling", "RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "RUNX1 regulates transcription of genes involved in interleukin signaling", "Regulation of RUNX3 expression and activity", "RUNX3 regulates p14-ARF", "Estrogen-dependent gene expression"], "361399": ["mRNA decay by 5' to 3' exoribonuclease"], "361400": ["Calcineurin activates NFAT", "FCERI mediated Ca+2 mobilization", "CLEC7A (Dectin-1) induces NFAT activation"], "361401": ["Hydrolysis of LPC"], "361402": ["RMTs methylate histone arginines"], "361403": ["DNA Damage/Telomere Stress Induced Senescence"], "361407": ["COPI-mediated anterograde transport", "Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network"], "361415": ["Intraflagellar transport"], "361416": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Deposition of new CENPA-containing nucleosomes at the centromere", "Mitotic Prometaphase"], "361420": ["B-WICH complex positively regulates rRNA expression", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase I Transcription Termination"], "361422": ["Neutrophil degranulation"], "361432": ["CDO in myogenesis", "Adherens junctions interactions"], "361433": ["Glycerophospholipid biosynthesis"], "361435": ["Fanconi Anemia Pathway"], "361438": ["Activation of SMO"], "361439": ["Mitochondrial ABC transporters"], "361449": ["mRNA Splicing - Major Pathway"], "361452": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "361467": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PG", "Synthesis of PA", "Synthesis of PC", "Neutrophil degranulation"], "361472": ["Metabolism of folate and pterines"], "361473": ["Mitochondrial translation termination"], "361502": ["COPII-mediated vesicle transport"], "361505": ["MAPK6/MAPK4 signaling"], "361509": ["TGF-beta receptor signaling activates SMADs", "Dectin-1 mediated noncanonical NF-kB signaling", "NIK-->noncanonical NF-kB signaling", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "361510": ["Cytosolic sulfonation of small molecules"], "361512": ["Factors involved in megakaryocyte development and platelet production"], "361522": ["mRNA Splicing - Major Pathway"], "361527": ["Role of phospholipids in phagocytosis"], "361531": ["Formation of RNA Pol II elongation complex ", "RNA Polymerase II Pre-transcription Events", "RNA Polymerase II Transcription Elongation", "E3 ubiquitin ligases ubiquitinate target proteins"], "361537": ["DAP12 interactions", "DAP12 signaling", "Signal regulatory protein family interactions", "Other semaphorin interactions", "Neutrophil degranulation"], "361542": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing"], "361549": ["LGI-ADAM interactions"], "361568": ["Sema4D mediated inhibition of cell attachment and migration"], "361574": ["mRNA Splicing - Major Pathway"], "361577": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "361580": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "mRNA Capping", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase I Transcription Termination", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE"], "361585": ["Antigen processing: Ubiquitination & Proteasome degradation"], "361596": ["Transcriptional activation of mitochondrial biogenesis", "Citric acid cycle (TCA cycle)"], "361597": ["Signaling by SCF-KIT", "Sema3A PAK dependent Axon repulsion", "CRMPs in Sema3A signaling"], "361598": ["Nephrin family interactions", "RHO GTPases activate IQGAPs", "MAP2K and MAPK activation", "Neutrophil degranulation"], "361602": ["Citric acid cycle (TCA cycle)"], "361605": ["Cleavage of Growing Transcript in the Termination Region ", "RNA polymerase II transcribes snRNA genes", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "361613": ["Cyclin A/B1/B2 associated events during G2/M transition"], "361617": ["Rho GTPase cycle", "PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1"], "361618": ["Ion homeostasis", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "361627": ["RNA polymerase II transcribes snRNA genes", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "361630": ["YAP1- and WWTR1 (TAZ)-stimulated gene expression", "RUNX3 regulates YAP1-mediated transcription"], "361632": ["Synthesis of PIPs at the plasma membrane", "Synthesis of PIPs at the Golgi membrane", "Synthesis of PIPs at the early endosome membrane", "Golgi Associated Vesicle Biogenesis", "Clathrin-mediated endocytosis"], "361634": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "Ub-specific processing proteases", "AURKA Activation by TPX2"], "361635": ["Neutrophil degranulation"], "361640": ["RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "361645": ["SUMOylation of DNA damage response and repair proteins"], "361655": ["FGFR2 alternative splicing"], "361659": ["Synthesis of PIPs at the plasma membrane"], "361662": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "APC/C:Cdc20 mediated degradation of mitotic proteins", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "361663": ["Purine ribonucleoside monophosphate biosynthesis"], "361673": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "361676": ["Acyl chain remodeling of DAG and TAG", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "361677": ["Neutrophil degranulation", "Interleukin-1 signaling"], "361686": ["Acyl chain remodelling of PS"], "361688": ["PKMTs methylate histone lysines"], "361689": ["Trafficking and processing of endosomal TLR"], "361694": ["Synthesis of PI"], "361696": ["AKT phosphorylates targets in the nucleus"], "361697": ["Neutrophil degranulation", "TBC/RABGAPs"], "361698": ["Recognition of DNA damage by PCNA-containing replication complex", "Polymerase switching on the C-strand of the telomere", "Processive synthesis on the C-strand of the telomere", "Telomere C-strand (Lagging Strand) Synthesis", "Removal of the Flap Intermediate from the C-strand", "PCNA-Dependent Long Patch Base Excision Repair", "Termination of translesion DNA synthesis", "HDR through Homologous Recombination (HRR)", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Polymerase switching", "Removal of the Flap Intermediate", "Processive synthesis on the lagging strand"], "361700": ["HDMs demethylate histones"], "361704": ["MHC class II antigen presentation"], "361705": ["COPII-mediated vesicle transport", "Cargo concentration in the ER"], "361710": ["Rap1 signalling"], "361712": ["Hedgehog ligand biogenesis", "ER Quality Control Compartment (ERQC)"], "361714": ["Integrin alphaIIb beta3 signaling", "Rap1 signalling"], "361724": ["Regulation of TP53 Activity through Acetylation", "RNA Polymerase I Transcription Initiation", "Regulation of PTEN gene transcription"], "361727": ["Anchoring of the basal body to the plasma membrane"], "361730": ["Fructose catabolism"], "361736": ["mRNA decay by 5' to 3' exoribonuclease"], "361745": ["RMTs methylate histone arginines", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "361751": ["Nicotinamide salvaging"], "361755": ["Amino acid synthesis and interconversion (transamination)"], "361765": ["Activation of NF-kappaB in B cells", "Prolactin receptor signaling", "SCF-beta-TrCP mediated degradation of Emi1", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of PLK1 Activity at G2/M Transition", "FCERI mediated NF-kB activation", "Deactivation of the beta-catenin transactivating complex", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "NIK-->noncanonical NF-kB signaling", "MAP3K8 (TPL2)-dependent MAPK1/3 activation", "Neddylation", "Interleukin-1 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "361767": ["Nonhomologous End-Joining (NHEJ)"], "361769": ["Degradation of GLI1 by the proteasome", "GLI3 is processed to GLI3R by the proteasome", "Hedgehog 'off' state", "Hedgehog 'on' state"], "361784": ["B-WICH complex positively regulates rRNA expression", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase I Transcription Termination"], "361789": ["Cilium Assembly"], "361795": ["TNFR2 non-canonical NF-kB pathway", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "361798": ["Senescence-Associated Secretory Phenotype (SASP)", "PKMTs methylate histone lysines", "Regulation of TP53 Activity through Methylation", "RNA Polymerase I Transcription Initiation", "Transcriptional Regulation by E2F6"], "361801": ["Nuclear Receptor transcription pathway", "Signaling by Retinoic Acid"], "361802": ["Fatty acyl-CoA biosynthesis"], "361807": ["Depolymerisation of the Nuclear Lamina"], "361808": ["mRNA Splicing - Major Pathway"], "361810": ["HSP90 chaperone cycle for steroid hormone receptors (SHR)", "ESR-mediated signaling"], "361814": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing"], "361815": ["Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "G2/M DNA damage checkpoint"], "361821": ["Collagen biosynthesis and modifying enzymes"], "361825": ["RMTs methylate histone arginines", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "361831": ["Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Inactivation of APC/C via direct inhibition of the APC/C complex", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Downstream TCR signaling", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "FCERI mediated NF-kB activation", "CLEC7A (Dectin-1) signaling", "Ovarian tumor domain proteases", "CDK-mediated phosphorylation and removal of Cdc6", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "E3 ubiquitin ligases ubiquitinate target proteins", "Neddylation", "Peroxisomal protein import", "Antigen processing: Ubiquitination & Proteasome degradation"], "361842": ["Cytosolic tRNA aminoacylation", "Pyrophosphate hydrolysis"], "361846": ["WNT ligand biogenesis and trafficking"], "361849": ["mRNA Splicing - Major Pathway"], "361858": ["RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter"], "361859": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing"], "361866": ["Antigen processing: Ubiquitination & Proteasome degradation"], "361882": ["EPHB-mediated forward signaling"], "361883": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "361884": ["Biotin transport and metabolism", "Branched-chain amino acid catabolism"], "361886": ["O-glycosylation of TSR domain-containing proteins"], "361887": ["mRNA Splicing - Major Pathway"], "361894": ["Complex I biogenesis"], "361907": ["FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "361916": ["Macroautophagy", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "361925": ["RMTs methylate histone arginines", "UCH proteinases", "DNA Damage Recognition in GG-NER", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "361930": ["BBSome-mediated cargo-targeting to cilium"], "361944": ["RUNX1 regulates transcription of genes involved in BCR signaling"], "361967": ["ESR-mediated signaling"], "361969": ["Platelet degranulation ", "Common Pathway of Fibrin Clot Formation", "Integrin cell surface interactions", "Integrin alphaIIb beta3 signaling", "GRB2:SOS provides linkage to MAPK signaling for Integrins ", "p130Cas linkage to MAPK signaling for integrins", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "MAP2K and MAPK activation", "Post-translational protein phosphorylation"], "361986": ["Zinc influx into cells by the SLC39 gene family"], "361988": ["RNA polymerase II transcribes snRNA genes"], "361990": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA 3'-end processing"], "361992": ["PIP3 activates AKT signaling", "Activation of AKT2", "Negative regulation of the PI3K/AKT network", "CD28 dependent PI3K/Akt signaling", "VEGFR2 mediated vascular permeability", "Mitochondrial Fatty Acid Beta-Oxidation"], "361993": ["Mitochondrial Fatty Acid Beta-Oxidation"], "361995": ["mRNA Splicing - Major Pathway"], "362002": ["Antigen processing: Ubiquitination & Proteasome degradation"], "362013": ["Ion homeostasis"], "362015": ["Purine salvage"], "362021": ["G alpha (i) signalling events"], "362029": ["Neutrophil degranulation", "Glycogen breakdown (glycogenolysis)"], "362031": ["Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"], "362035": ["HS-GAG biosynthesis"], "362039": ["Acyl chain remodelling of PS", "Acyl chain remodelling of PG"], "362044": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "COPI-dependent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "Kinesins"], "362045": ["Macroautophagy", "mTOR signalling", "mTORC1-mediated signalling", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "MAP2K and MAPK activation", "Neutrophil degranulation", "Regulation of PTEN gene transcription"], "362046": ["Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "362053": ["Stimuli-sensing channels"], "362058": ["Synthesis of PA"], "362065": ["WNT ligand biogenesis and trafficking"], "362076": ["Interleukin-36 pathway"], "362077": ["Interleukin-38 signaling", "Interleukin-36 pathway"], "362081": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "362087": ["Antigen processing: Ubiquitination & Proteasome degradation"], "362093": ["PKMTs methylate histone lysines", "HATs acetylate histones", "RMTs methylate histone arginines", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Neddylation"], "362095": ["RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter"], "362098": ["Transport of Mature mRNA derived from an Intron-Containing Transcript"], "362110": ["Formation of RNA Pol II elongation complex ", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Transcription Elongation", "Estrogen-dependent gene expression"], "362118": ["Endosomal Sorting Complex Required For Transport (ESCRT)"], "362133": ["Post-translational modification: synthesis of GPI-anchored proteins"], "362134": ["Cobalamin (Cbl, vitamin B12) transport and metabolism"], "362142": ["BBSome-mediated cargo-targeting to cilium"], "362152": ["mRNA Splicing - Major Pathway"], "362162": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "362166": ["Factors involved in megakaryocyte development and platelet production"], "362176": ["RUNX1 regulates transcription of genes involved in differentiation of HSCs"], "362182": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "362186": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "COPI-dependent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "Kinesins"], "362196": ["Glutathione synthesis and recycling"], "362203": ["Recruitment of mitotic centrosome proteins and complexes", "Recruitment of NuMA to mitotic centrosomes"], "362214": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "362216": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "362223": ["mRNA Splicing - Major Pathway"], "362229": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "362237": ["COPII-mediated vesicle transport"], "362245": ["Macroautophagy", "Pink/Parkin Mediated Mitophagy", "Receptor Mediated Mitophagy"], "362247": ["TRP channels"], "362248": ["Common Pathway of Fibrin Clot Formation", "Cell surface interactions at the vascular wall"], "362249": ["Glycerophospholipid biosynthesis", "Neutrophil degranulation"], "362261": ["Synthesis of PC", "Synthesis of PE", "Depolymerisation of the Nuclear Lamina", "Triglyceride biosynthesis"], "362262": ["Molecules associated with elastic fibres"], "362264": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "mRNA 3'-end processing"], "362271": ["Regulation of actin dynamics for phagocytic cup formation", "VEGFA-VEGFR2 Pathway", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases"], "362272": ["Regulation of TP53 Activity through Phosphorylation"], "362275": ["O-linked glycosylation of mucins", "N-Glycan antennae elongation"], "362277": ["Antigen processing: Ubiquitination & Proteasome degradation"], "362279": ["Tight junction interactions"], "362280": ["SUMOylation of transcription factors", "Negative regulation of activity of TFAP2 (AP-2) family transcription factors", "Activation of the TFAP2 (AP-2) family of transcription factors", "TFAP2 (AP-2) family regulates transcription of cell cycle factors"], "362281": ["Transport of Mature mRNA derived from an Intron-Containing Transcript", "SUMOylation of DNA damage response and repair proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of DNA replication proteins"], "362282": ["Gluconeogenesis"], "362283": ["Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network"], "362285": ["Collagen biosynthesis and modifying enzymes", "Signaling by PDGF", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "ECM proteoglycans", "NCAM1 interactions", "Collagen chain trimerization"], "362288": ["Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)"], "362293": ["Regulation of HSF1-mediated heat shock response"], "362302": ["Mitochondrial ABC transporters"], "362304": ["Activation of ATR in response to replication stress", "Assembly of the ORC complex at the origin of replication", "CDC6 association with the ORC:origin complex", "CDT1 association with the CDC6:ORC:origin complex", "Assembly of the pre-replicative complex", "Orc1 removal from chromatin", "Activation of the pre-replicative complex"], "362329": ["Neutrophil degranulation", "Purine ribonucleoside monophosphate biosynthesis"], "362332": ["Cell-extracellular matrix interactions"], "362335": ["Transport of Mature mRNA derived from an Intron-Containing Transcript", "SUMOylation of DNA damage response and repair proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of DNA replication proteins"], "362342": ["SUMOylation of transcription cofactors", "Regulation of TP53 Activity through Phosphorylation", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "362344": ["Respiratory electron transport", "Complex I biogenesis"], "362347": ["Collagen degradation", "Activation of Matrix Metalloproteinases", "Cobalamin (Cbl, vitamin B12) transport and metabolism", "Neutrophil degranulation", "Antimicrobial peptides"], "362356": ["Activation of NF-kappaB in B cells", "Prolactin receptor signaling", "SCF-beta-TrCP mediated degradation of Emi1", "SCF(Skp2)-mediated degradation of p27/p21", "Degradation of beta-catenin by the destruction complex", "Downstream TCR signaling", "Regulation of PLK1 Activity at G2/M Transition", "FCERI mediated NF-kB activation", "Dectin-1 mediated noncanonical NF-kB signaling", "CLEC7A (Dectin-1) signaling", "NIK-->noncanonical NF-kB signaling", "MAP3K8 (TPL2)-dependent MAPK1/3 activation", "Orc1 removal from chromatin", "Cyclin D associated events in G1", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "Regulation of RUNX2 expression and activity", "Neddylation", "Interleukin-1 signaling", "Iron uptake and transport", "Antigen processing: Ubiquitination & Proteasome degradation"], "362360": ["Synthesis of bile acids and bile salts"], "362368": ["Glutathione synthesis and recycling"], "362376": ["Antigen processing: Ubiquitination & Proteasome degradation"], "362377": ["Antigen processing: Ubiquitination & Proteasome degradation"], "362378": ["Rho GTPase cycle"], "362383": ["Pentose phosphate pathway"], "362384": ["Olfactory Signaling Pathway"], "362385": ["Recognition of DNA damage by PCNA-containing replication complex", "Telomere C-strand synthesis initiation", "PCNA-Dependent Long Patch Base Excision Repair", "Termination of translesion DNA synthesis", "HDR through Homologous Recombination (HRR)", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "DNA replication initiation", "Activation of the pre-replicative complex"], "362388": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "362394": ["Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "mRNA Splicing - Major Pathway"], "362398": ["Sema3A PAK dependent Axon repulsion", "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "CRMPs in Sema3A signaling", "Other semaphorin interactions"], "362409": ["Glycosphingolipid metabolism", "The activation of arylsulfatases"], "362412": ["Recognition of DNA damage by PCNA-containing replication complex", "E3 ubiquitin ligases ubiquitinate target proteins"], "362414": ["Ub-specific processing proteases"], "362417": ["Interleukin-17 signaling"], "362418": ["NOD1/2 Signaling Pathway", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "Interleukin-1 signaling", "IRAK2 mediated activation of TAK1 complex", "TRAF6-mediated induction of TAK1 complex within TLR4 complex", "TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "MyD88 dependent cascade initiated on endosome", "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"], "362429": ["Elastic fibre formation", "Molecules associated with elastic fibres"], "362434": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PS", "Acyl chain remodelling of PE"], "362440": ["Respiratory electron transport", "Complex I biogenesis"], "362454": ["G alpha (i) signalling events", "Formyl peptide receptors bind formyl peptides and many other ligands"], "362456": ["Rho GTPase cycle"], "362466": ["COPI-independent Golgi-to-ER retrograde traffic"], "362474": ["Interconversion of 2-oxoglutarate and 2-hydroxyglutarate"], "362479": ["Formation of RNA Pol II elongation complex ", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "RNA Polymerase II Transcription Elongation"], "362485": ["G0 and Early G1", "SCF(Skp2)-mediated degradation of p27/p21", "DNA Damage/Telomere Stress Induced Senescence", "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "CDK-mediated phosphorylation and removal of Cdc6", "Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes", "Cyclin E associated events during G1/S transition ", "p53-Dependent G1 DNA Damage Response"], "362491": ["NOD1/2 Signaling Pathway", "p75NTR recruits signalling complexes", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "Ovarian tumor domain proteases", "Interleukin-1 signaling"], "362495": ["Complex I biogenesis"], "362501": ["SUMOylation of transcription cofactors", "SUMOylation of SUMOylation proteins"], "362502": ["Endosomal Sorting Complex Required For Transport (ESCRT)"], "362504": ["MHC class II antigen presentation", "Regulation of PLK1 Activity at G2/M Transition", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic", "AURKA Activation by TPX2"], "362505": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "362506": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "362511": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "362513": ["VEGFA-VEGFR2 Pathway"], "362517": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "362519": ["Condensation of Prophase Chromosomes", "Condensation of Prometaphase Chromosomes"], "362524": ["EGFR downregulation"], "362533": ["Formation of the beta-catenin:TCF transactivating complex", "Deactivation of the beta-catenin transactivating complex", "Repression of WNT target genes"], "362537": ["RNA polymerase II transcribes snRNA genes", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "362540": ["Synthesis of very long-chain fatty acyl-CoAs"], "362548": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "NRIF signals cell death from the nucleus", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Deposition of new CENPA-containing nucleosomes at the centromere", "Mitotic Prometaphase"], "362549": ["Activation of SMO"], "362553": ["Intraflagellar transport"], "362566": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "362567": ["O-linked glycosylation"], "362572": ["RAF/MAP kinase cascade", "RET signaling"], "362581": ["Oxidative Stress Induced Senescence", "SUMOylation of transcription cofactors", "SUMOylation of chromatin organization proteins", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Regulation of PTEN gene transcription"], "362584": ["Collagen biosynthesis and modifying enzymes", "Signaling by PDGF", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "ECM proteoglycans", "NCAM1 interactions", "Collagen chain trimerization"], "362588": ["Respiratory electron transport", "Complex I biogenesis"], "362590": ["Synthesis of IP2, IP, and Ins in the cytosol", "Synthesis of IP3 and IP4 in the cytosol", "Rho GTPase cycle"], "362594": ["HATs acetylate histones", "Regulation of TP53 Activity through Acetylation"], "362599": ["COPII-mediated vesicle transport", "RAB GEFs exchange GTP for GDP on RABs"], "362600": ["POLB-Dependent Long Patch Base Excision Repair"], "362609": ["Golgi Associated Vesicle Biogenesis"], "362612": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing"], "362623": ["Sperm Motility And Taxes"], "362625": ["Intra-Golgi traffic", "Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2"], "362628": ["Interleukin-20 family signaling"], "362629": ["Interleukin-20 family signaling"], "362634": ["Initial triggering of complement", "Classical antibody-mediated complement activation", "Regulation of Complement cascade"], "362636": ["Ub-specific processing proteases"], "362638": ["Neutrophil degranulation", "Pyrimidine salvage"], "362642": ["Miscellaneous transport and binding events"], "362648": ["NRAGE signals death through JNK", "Rho GTPase cycle"], "362650": ["Cell-extracellular matrix interactions"], "362653": ["Cobalamin (Cbl, vitamin B12) transport and metabolism"], "362657": ["Metabolism of folate and pterines"], "362675": ["Regulation of TP53 Activity through Association with Co-factors", "RUNX1 regulates transcription of genes involved in differentiation of HSCs"], "362687": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "mRNA 3'-end processing"], "362688": ["snRNP Assembly"], "362701": ["Degradation of the extracellular matrix"], "362702": ["Acyl chain remodeling of CL", "Synthesis of PA"], "362703": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "362704": ["Metalloprotease DUBs", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "G2/M DNA damage checkpoint"], "362706": ["Pentose phosphate pathway"], "362720": ["Interconversion of nucleotide di- and triphosphates"], "362728": ["B-WICH complex positively regulates rRNA expression", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase I Transcription Termination"], "362732": ["Triglyceride biosynthesis"], "362736": ["Antigen processing: Ubiquitination & Proteasome degradation"], "362749": ["Formation of ATP by chemiosmotic coupling", "Cristae formation"], "362756": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "362757": ["The canonical retinoid cycle in rods (twilight vision)", "RA biosynthesis pathway", "Retinoid metabolism and transport"], "362760": ["O-linked glycosylation of mucins"], "362762": ["Neddylation"], "362776": ["Mitochondrial iron-sulfur cluster biogenesis"], "362779": ["Initiation of Nuclear Envelope Reformation"], "362782": ["Synthesis of bile acids and bile salts via 24-hydroxycholesterol", "Endogenous sterols"], "362788": ["TNFR2 non-canonical NF-kB pathway", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "Ovarian tumor domain proteases", "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon"], "362792": ["Synthesis of IP3 and IP4 in the cytosol", "Role of phospholipids in phagocytosis"], "362798": ["Condensation of Prophase Chromosomes"], "362800": ["Molecules associated with elastic fibres", "Integrin cell surface interactions"], "362809": ["Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "HSF1 activation", "Attenuation phase", "Aryl hydrocarbon receptor signalling", "ESR-mediated signaling", "Estrogen-dependent gene expression"], "362810": ["Respiratory electron transport"], "362813": ["RNA polymerase II transcribes snRNA genes"], "362814": ["Downregulation of ERBB2:ERBB3 signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "362817": ["G0 and Early G1", "Activation of ATR in response to replication stress", "Regulation of APC/C activators between G1/S and early anaphase", "SCF(Skp2)-mediated degradation of p27/p21", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "Processing of DNA double-strand break ends", "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "Regulation of TP53 Degradation", "G2 Phase", "Orc1 removal from chromatin", "Activation of the pre-replicative complex", "CDK-mediated phosphorylation and removal of Cdc6", "Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes", "Cyclin E associated events during G1/S transition ", "Cyclin A/B1/B2 associated events during G2/M transition", "p53-Dependent G1 DNA Damage Response", "Cyclin A:Cdk2-associated events at S phase entry", "PTK6 Regulates Cell Cycle"], "362819": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA 3'-end processing"], "362825": ["Factors involved in megakaryocyte development and platelet production"], "362827": ["SUMOylation of DNA damage response and repair proteins", "SUMOylation of transcription factors", "SUMOylation of SUMOylation proteins", "SUMOylation of intracellular receptors", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "G2/M DNA damage checkpoint"], "362828": ["Regulation of TNFR1 signaling"], "362829": ["mRNA decay by 5' to 3' exoribonuclease", "mRNA Splicing - Major Pathway"], "362831": ["PKMTs methylate histone lysines"], "362832": ["Sperm:Oocyte Membrane Binding"], "362834": ["Regulation of TP53 Activity through Acetylation", "RNA Polymerase I Transcription Initiation", "Regulation of PTEN gene transcription"], "362835": ["Olfactory Signaling Pathway"], "362837": ["Respiratory electron transport", "Complex I biogenesis"], "362842": ["Rho GTPase cycle"], "362850": ["Assembly of active LPL and LIPC lipase complexes"], "362851": ["Cobalamin (Cbl, vitamin B12) transport and metabolism"], "362858": ["RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "362859": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Surfactant metabolism", "Neutrophil degranulation", "Post-translational protein phosphorylation"], "362861": ["Metal ion SLC transporters"], "362866": ["Synthesis of PC"], "362867": ["Striated Muscle Contraction"], "362881": ["Neutrophil degranulation", "Antimicrobial peptides"], "362891": ["ABC-family proteins mediated transport", "Hedgehog ligand biogenesis", "ER Quality Control Compartment (ERQC)"], "362893": ["Rho GTPase cycle", "Neutrophil degranulation"], "362896": ["Downstream signal transduction", "STAT6-mediated induction of chemokines", "Interleukin-4 and Interleukin-13 signaling"], "362899": ["Miscellaneous transport and binding events"], "362900": ["Antigen processing: Ubiquitination & Proteasome degradation"], "362902": ["Major pathway of rRNA processing in the nucleolus and cytosol", "Neddylation"], "362924": ["Keratan sulfate biosynthesis", "Sialic acid metabolism", "Termination of O-glycan biosynthesis"], "362934": ["Post-translational modification: synthesis of GPI-anchored proteins"], "362936": ["Generic Transcription Pathway"], "362942": ["Vitamin B2 (riboflavin) metabolism"], "362948": ["Generic Transcription Pathway"], "362950": ["FGFR2 alternative splicing"], "362951": ["Scavenging of heme from plasma", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "362952": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "362965": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA replication proteins", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "362966": ["Neutrophil degranulation"], "362967": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "362972": ["Acyl chain remodeling of DAG and TAG"], "362973": ["Regulation of cytoskeletal remodeling and cell spreading by IPP complex components"], "362983": ["RAB GEFs exchange GTP for GDP on RABs"], "362990": ["mRNA Splicing - Minor Pathway"], "362993": ["Sema4D mediated inhibition of cell attachment and migration", "Sema4D induced cell migration and growth-cone collapse"], "363002": ["RMTs methylate histone arginines", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "363006": ["MicroRNA (miRNA) biogenesis", "Small interfering RNA (siRNA) biogenesis"], "363014": ["Nuclear signaling by ERBB4", "Signaling by Hippo", "YAP1- and WWTR1 (TAZ)-stimulated gene expression", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "RUNX3 regulates YAP1-mediated transcription"], "363017": ["B-WICH complex positively regulates rRNA expression", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase I Transcription Termination"], "363023": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "363024": ["Synthesis of PC", "Transport of bile salts and organic acids, metal ions and amine compounds", "Neutrophil degranulation"], "363026": ["RMTs methylate histone arginines", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)", "Estrogen-dependent gene expression"], "363028": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "363040": ["Keratan sulfate biosynthesis", "Sialic acid metabolism", "N-Glycan antennae elongation", "Termination of O-glycan biosynthesis"], "363059": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "COPI-dependent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase"], "363060": ["Post-translational modification: synthesis of GPI-anchored proteins"], "363061": ["Citric acid cycle (TCA cycle)"], "363064": ["Formation of RNA Pol II elongation complex ", "mRNA decay by 3' to 5' exoribonuclease", "RNA Polymerase II Pre-transcription Events", "RNA Polymerase II Transcription Elongation", "E3 ubiquitin ligases ubiquitinate target proteins"], "363067": ["SUMOylation of transcription cofactors", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Regulation of MECP2 expression and activity"], "363068": ["Neddylation"], "363069": ["Coenzyme A biosynthesis"], "363071": ["The canonical retinoid cycle in rods (twilight vision)"], "363082": ["mRNA Splicing - Minor Pathway"], "363083": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "363085": ["Reversible hydration of carbon dioxide"], "363103": ["Sialic acid metabolism", "Organic anion transporters"], "363104": ["Platelet degranulation ", "Post-translational modification: synthesis of GPI-anchored proteins"], "363109": ["Synthesis of UDP-N-acetyl-glucosamine"], "363115": ["Sodium/Proton exchangers"], "363118": ["Nicotinate metabolism"], "363120": ["Glycosphingolipid metabolism"], "363123": ["COPI-independent Golgi-to-ER retrograde traffic", "Retrograde transport at the Trans-Golgi-Network", "TBC/RABGAPs", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "363127": ["Neutrophil degranulation"], "363131": ["PI3K Cascade", "Macroautophagy", "Synthesis of PIPs at the early endosome membrane", "Toll Like Receptor 9 (TLR9) Cascade", "RHO GTPases Activate NADPH Oxidases"], "363134": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "363136": ["COPI-mediated anterograde transport"], "363143": ["PLC beta mediated events", "G-protein activation", "Activation of the phototransduction cascade", "Inactivation, recovery and regulation of the phototransduction cascade", "G alpha (i) signalling events", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "363158": ["Collagen biosynthesis and modifying enzymes"], "363159": ["Synthesis of PA"], "363164": ["Recognition of DNA damage by PCNA-containing replication complex", "Ub-specific processing proteases", "Fanconi Anemia Pathway"], "363170": ["Generic Transcription Pathway"], "363187": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "363195": ["Platelet degranulation "], "363221": ["Deadenylation of mRNA", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "363227": ["RNA polymerase II transcribes snRNA genes"], "363237": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "363251": ["Nonhomologous End-Joining (NHEJ)"], "363254": ["Macroautophagy"], "363259": ["Neddylation"], "363261": ["Triglyceride biosynthesis"], "363265": ["Collagen biosynthesis and modifying enzymes", "Integrin cell surface interactions"], "363272": ["ARL13B-mediated ciliary trafficking of INPP5E"], "363273": ["DNA Damage Recognition in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Cargo recognition for clathrin-mediated endocytosis", "Neddylation"], "363275": ["ISG15 antiviral mechanism"], "363278": ["Macroautophagy"], "363283": ["DNA Damage Recognition in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Cargo recognition for clathrin-mediated endocytosis", "Neddylation"], "363284": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "363285": ["Metabolism of ingested SeMet, Sec, MeSec into H2Se"], "363286": ["Intraflagellar transport"], "363287": ["SUMOylation of intracellular receptors", "SUMOylation of chromatin organization proteins", "RUNX3 regulates p14-ARF"], "363288": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "363292": ["HATs acetylate histones", "Regulation of TP53 Activity through Acetylation"], "363441": ["Respiratory electron transport", "Complex I biogenesis"], "363442": ["Receptor Mediated Mitophagy"], "363445": ["Downregulation of SMAD2/3:SMAD4 transcriptional activity", "Ub-specific processing proteases", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Peroxisomal protein import"], "363457": ["Collagen degradation", "Extracellular matrix organization", "Collagen biosynthesis and modifying enzymes", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "Anchoring fibril formation", "Crosslinking of collagen fibrils", "Laminin interactions", "Non-integrin membrane-ECM interactions"], "363462": ["snRNP Assembly"], "363463": ["Neutrophil degranulation"], "363464": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "363465": ["Digestion"], "363469": ["Metabolism of polyamines"], "363471": ["Triglyceride catabolism"], "363476": ["Golgi Associated Vesicle Biogenesis"], "363481": ["Separation of Sister Chromatids"], "363493": ["RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "363516": ["ABC transporters in lipid homeostasis", "alpha-linolenic acid (ALA) metabolism", "Beta-oxidation of very long chain fatty acids"], "363517": ["Other semaphorin interactions"], "363519": ["HATs acetylate histones", "UCH proteinases"], "363520": ["PIP3 activates AKT signaling", "NOD1/2 Signaling Pathway", "p75NTR recruits signalling complexes", "NF-kB is activated and signals survival", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Interleukin-1 signaling", "IRAK1 recruits IKK complex", "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "MyD88 dependent cascade initiated on endosome"], "363521": ["Acyl chain remodeling of CL"], "363522": ["Neutrophil degranulation"], "363544": ["Intraflagellar transport"], "363546": ["Olfactory Signaling Pathway"], "363549": ["Olfactory Signaling Pathway"], "363577": ["Generation of second messenger molecules", "FCERI mediated Ca+2 mobilization"], "363599": ["Ovarian tumor domain proteases"], "363603": ["Deadenylation of mRNA", "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "363616": ["Signaling by SCF-KIT"], "363618": ["HS-GAG biosynthesis"], "363633": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Transcriptional regulation by small RNAs", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE", "Estrogen-dependent gene expression"], "363646": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "363658": ["Association of TriC/CCT with target proteins during biosynthesis", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "363675": ["Pregnenolone biosynthesis"], "363677": ["Gap junction assembly"], "363678": ["Keratinization"], "363682": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "363720": ["Macroautophagy", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "363735": ["Transcriptional activation of mitochondrial biogenesis"], "363760": ["BBSome-mediated cargo-targeting to cilium"], "363761": ["Olfactory Signaling Pathway"], "363762": ["Olfactory Signaling Pathway"], "363763": ["Olfactory Signaling Pathway"], "363790": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "363826": ["Olfactory Signaling Pathway"], "363830": ["Cell surface interactions at the vascular wall"], "363849": ["Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "363854": ["HuR (ELAVL1) binds and stabilizes mRNA", "mRNA Splicing - Major Pathway"], "363855": ["Oxidative Stress Induced Senescence", "FCERI mediated MAPK activation", "JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1"], "363856": ["CD209 (DC-SIGN) signaling", "Butyrophilin (BTN) family interactions"], "363858": ["COPII-mediated vesicle transport", "RAB GEFs exchange GTP for GDP on RABs"], "363866": ["G alpha (s) signalling events", "Relaxin receptors"], "363872": ["Generic Transcription Pathway"], "363875": ["GPVI-mediated activation cascade", "PIP3 activates AKT signaling", "Signaling by SCF-KIT", "NRAGE signals death through JNK", "Rho GTPase cycle", "Regulation of actin dynamics for phagocytic cup formation", "DAP12 signaling", "FCERI mediated MAPK activation", "DSCAM interactions", "CD28 dependent Vav1 pathway", "EPHB-mediated forward signaling", "Ephrin signaling", "EPH-ephrin mediated repulsion of cells", "Sema3A PAK dependent Axon repulsion", "PCP/CE pathway", "Sema4D mediated inhibition of cell attachment and migration", "DCC mediated attractive signaling", "VEGFA-VEGFR2 Pathway", "Signal transduction by L1", "VEGFR2 mediated vascular permeability", "RHO GTPases activate PKNs", "RHO GTPases activate CIT", "RHO GTPases activate KTN1", "RHO GTPases activate IQGAPs", "RHO GTPases activate PAKs", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate Formins", "RHO GTPases Activate NADPH Oxidases", "MAPK6/MAPK4 signaling", "Neutrophil degranulation", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "MET activates RAP1 and RAC1", "NTRK2 activates RAC1", "Factors involved in megakaryocyte development and platelet production"], "363924": ["Activation of ATR in response to replication stress", "HDR through Single Strand Annealing (SSA)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange"], "363982": ["Ovarian tumor domain proteases"], "363984": ["SUMOylation of immune response proteins", "Negative regulators of DDX58/IFIH1 signaling", "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon"], "363985": ["Metal ion SLC transporters"], "363993": ["G alpha (s) signalling events"], "364032": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "364033": ["Retrograde transport at the Trans-Golgi-Network", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "364049": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "364050": ["Neddylation"], "364052": ["RAF-independent MAPK1/3 activation", "RAF/MAP kinase cascade"], "364064": ["Amino acid synthesis and interconversion (transamination)"], "364134": ["Synthesis of very long-chain fatty acyl-CoAs"], "364183": ["Golgi Associated Vesicle Biogenesis"], "364206": ["Platelet degranulation "], "364275": ["Olfactory Signaling Pathway"], "364298": ["PI5P Regulates TP53 Acetylation", "Synthesis of PIPs in the nucleus"], "364306": ["Olfactory Signaling Pathway"], "364380": ["Acyl chain remodelling of PE"], "364382": ["RMTs methylate histone arginines", "Regulation of TP53 Activity through Methylation"], "364386": ["Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway"], "364398": ["ER Quality Control Compartment (ERQC)"], "364419": ["Macroautophagy", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "364475": ["Hedgehog 'on' state"], "364594": ["Trafficking and processing of endosomal TLR"], "364601": ["Mitochondrial calcium ion transport", "Processing of SMDT1"], "364624": ["mRNA decay by 5' to 3' exoribonuclease"], "364629": ["Synthesis of PIPs at the Golgi membrane"], "364630": ["O-glycosylation of TSR domain-containing proteins"], "364656": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "364675": ["A tetrasaccharide linker sequence is required for GAG synthesis"], "364681": ["Antigen processing: Ubiquitination & Proteasome degradation"], "364682": ["Glycogen synthesis"], "364723": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "SUMOylation of chromatin organization proteins", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "364754": ["Asymmetric localization of PCP proteins", "Regulation of FZD by ubiquitination"], "364755": ["Insulin processing"], "364773": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "RA biosynthesis pathway", "Retinoid metabolism and transport"], "364785": ["PKMTs methylate histone lysines"], "364786": ["Molecules associated with elastic fibres", "Integrin cell surface interactions", "ECM proteoglycans"], "364814": ["UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "364834": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Transcriptional regulation by small RNAs", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE", "Estrogen-dependent gene expression"], "364838": ["Olfactory Signaling Pathway"], "364867": ["Toll Like Receptor 4 (TLR4) Cascade", "Neutrophil degranulation", "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon", "TRAF6-mediated induction of TAK1 complex within TLR4 complex"], "364901": ["Sialic acid metabolism"], "364973": ["Stimuli-sensing channels"], "364975": ["Lysine catabolism"], "364979": ["Olfactory Signaling Pathway"], "364981": ["Retrograde transport at the Trans-Golgi-Network"], "364994": ["Synthesis of Leukotrienes (LT) and Eoxins (EX)"], "365042": ["RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "365153": ["Intraflagellar transport"], "365155": ["PKMTs methylate histone lysines", "Meiotic recombination"], "365183": ["Neutrophil degranulation"], "365191": ["Macroautophagy", "Lysosome Vesicle Biogenesis", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "365192": ["Generic Transcription Pathway"], "365215": ["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "365222": ["Synaptic adhesion-like molecules"], "365224": ["Generic Transcription Pathway"], "365228": ["G alpha (q) signalling events", "Free fatty acid receptors"], "365241": ["Voltage gated Potassium channels"], "365277": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "365302": ["Olfactory Signaling Pathway"], "365314": ["Glyoxylate metabolism and glycine degradation"], "365323": ["Olfactory Signaling Pathway"], "365324": ["Olfactory Signaling Pathway"], "365327": ["Olfactory Signaling Pathway"], "365330": ["Olfactory Signaling Pathway"], "365334": ["Olfactory Signaling Pathway"], "365337": ["Olfactory Signaling Pathway"], "365340": ["Olfactory Signaling Pathway"], "365345": ["Erythrocytes take up carbon dioxide and release oxygen"], "365367": ["PIP3 activates AKT signaling", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Regulation of Complement cascade", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "365372": ["TBC/RABGAPs"], "365377": ["Smooth Muscle Contraction"], "365382": ["Synthesis of IP2, IP, and Ins in the cytosol"], "365384": ["Olfactory Signaling Pathway"], "365388": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "Neutrophil degranulation", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "365391": ["TRP channels"], "365398": ["Organic anion transport"], "365407": ["Cleavage of Growing Transcript in the Termination Region ", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "365410": ["Sphingolipid de novo biosynthesis", "Synthesis of bile acids and bile salts"], "365413": ["Olfactory Signaling Pathway"], "365460": ["Degradation of the extracellular matrix", "Collagen biosynthesis and modifying enzymes", "Anchoring fibril formation"], "365466": ["Regulation of Complement cascade"], "365523": ["Olfactory Signaling Pathway"], "365527": ["ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "365542": ["MHC class II antigen presentation"], "365547": ["Keratinization"], "365550": ["Cell surface interactions at the vascular wall"], "365567": ["Mitochondrial calcium ion transport", "Processing of SMDT1"], "365571": ["Peroxisomal protein import", "TYSND1 cleaves peroxisomal proteins"], "365581": ["TNFs bind their physiological receptors"], "365583": ["Dermatan sulfate biosynthesis"], "365592": ["Ubiquinol biosynthesis"], "365619": ["Glycosphingolipid metabolism", "The activation of arylsulfatases"], "365652": ["Sphingolipid de novo biosynthesis"], "365661": ["Signaling by ERBB2", "Downregulation of ERBB2 signaling"], "365684": ["Deadenylation of mRNA"], "365699": ["Nicotinate metabolism"], "365744": ["Nuclear Receptor transcription pathway"], "365755": ["Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)"], "365769": ["Interleukin-21 signaling"], "365793": ["Intra-Golgi traffic", "TBC/RABGAPs", "RAB geranylgeranylation"], "365855": ["Hedgehog 'on' state"], "365872": ["Regulated proteolysis of p75NTR", "NRIF signals cell death from the nucleus", "NOTCH3 Activation and Transmission of Signal to the Nucleus"], "365877": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Metalloprotease DUBs", "Deposition of new CENPA-containing nucleosomes at the centromere", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "365894": ["Downregulation of SMAD2/3:SMAD4 transcriptional activity"], "365895": ["Regulation of TP53 Activity through Phosphorylation"], "365901": ["PLC beta mediated events", "G-protein activation", "Ca2+ pathway", "G alpha (i) signalling events", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "365946": ["Stimuli-sensing channels"], "365962": ["Synthesis of PC", "Transport of bile salts and organic acids, metal ions and amine compounds"], "365985": ["Interconversion of nucleotide di- and triphosphates"], "366017": ["mRNA decay by 3' to 5' exoribonuclease", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "KSRP (KHSRP) binds and destabilizes mRNA", "Major pathway of rRNA processing in the nucleolus and cytosol"], "366061": ["FGFR3c ligand binding and activation", "O-linked glycosylation of mucins"], "366065": ["Sphingolipid de novo biosynthesis"], "366100": ["Olfactory Signaling Pathway"], "366102": ["Olfactory Signaling Pathway"], "366103": ["Olfactory Signaling Pathway"], "366111": ["Olfactory Signaling Pathway"], "366112": ["Olfactory Signaling Pathway"], "366115": ["Olfactory Signaling Pathway"], "366116": ["Olfactory Signaling Pathway"], "366118": ["Olfactory Signaling Pathway"], "366120": ["Olfactory Signaling Pathway"], "366121": ["Olfactory Signaling Pathway"], "366122": ["Olfactory Signaling Pathway"], "366123": ["Olfactory Signaling Pathway"], "366151": ["Olfactory Signaling Pathway"], "366163": ["Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "mRNA Splicing - Major Pathway"], "366169": ["Formation of RNA Pol II elongation complex ", "RNA Polymerase II Pre-transcription Events", "RNA Polymerase II Transcription Elongation", "E3 ubiquitin ligases ubiquitinate target proteins"], "366174": ["Sperm Motility And Taxes"], "366196": ["Acyl chain remodelling of PG", "Synthesis of CL"], "366265": ["RAB geranylgeranylation"], "366274": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "366275": ["SCF(Skp2)-mediated degradation of p27/p21", "Cyclin D associated events in G1", "ERBB2 Activates PTK6 Signaling", "PTK6 Regulates Proteins Involved in RNA Processing", "PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "PTK6 Regulates Cell Cycle", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "PTK6 Down-Regulation", "PTK6 Activates STAT3", "PTK6 promotes HIF1A stabilization"], "366276": ["mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "366277": ["RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "366311": ["Lysosome Vesicle Biogenesis"], "366381": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6", "Antigen processing: Ubiquitination & Proteasome degradation"], "366432": ["Glutamate Neurotransmitter Release Cycle", "Transport of inorganic cations/anions and amino acids/oligopeptides"], "366441": ["Cellular hexose transport"], "366461": ["mRNA Splicing - Major Pathway"], "366468": ["Cleavage of Growing Transcript in the Termination Region ", "SLBP independent Processing of Histone Pre-mRNAs", "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"], "366478": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "366492": ["EPH-Ephrin signaling", "EPHA-mediated growth cone collapse", "EPH-ephrin mediated repulsion of cells"], "366508": ["PIP3 activates AKT signaling", "Synthesis of PIPs at the plasma membrane", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "RET signaling", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "Interleukin receptor SHC signaling", "Regulation of signaling by CBL", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "366518": ["Costimulation by the CD28 family", "TNFs bind their physiological receptors"], "366545": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "366588": ["Lectin pathway of complement activation", "Initial triggering of complement"], "366618": ["Lysosome Vesicle Biogenesis"], "366668": ["Hormone ligand-binding receptors", "G alpha (s) signalling events"], "366734": ["Regulation of HSF1-mediated heat shock response"], "366791": ["The canonical retinoid cycle in rods (twilight vision)", "RA biosynthesis pathway"], "366816": ["Olfactory Signaling Pathway"], "366834": ["Olfactory Signaling Pathway"], "366854": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "366872": ["Anchoring of the basal body to the plasma membrane"], "366896": ["TBC/RABGAPs"], "366952": ["Cleavage of Growing Transcript in the Termination Region ", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "366957": ["GPVI-mediated activation cascade", "PIP3 activates AKT signaling", "Rho GTPase cycle", "PCP/CE pathway", "RHO GTPases Activate NADPH Oxidases", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "366960": ["Factors involved in megakaryocyte development and platelet production"], "366980": ["RMTs methylate histone arginines", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "366984": ["Sphingolipid de novo biosynthesis"], "366998": ["Factors involved in megakaryocyte development and platelet production"], "367034": ["Generic Transcription Pathway"], "367039": ["Factors involved in megakaryocyte development and platelet production"], "367083": ["Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"], "367085": ["Rho GTPase cycle"], "367086": ["Ion homeostasis", "Ion transport by P-type ATPases"], "367090": ["Cleavage of the damaged pyrimidine ", "APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway"], "367112": ["Synthesis of Ketone Bodies"], "367117": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "367145": ["Keratan sulfate biosynthesis"], "367152": ["SUMOylation of transcription factors"], "367153": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "367167": ["Antigen processing: Ubiquitination & Proteasome degradation"], "367201": ["Cytosolic sulfonation of small molecules"], "367218": ["Transcriptional regulation by RUNX2", "Regulation of RUNX2 expression and activity", "RUNX2 regulates osteoblast differentiation", "RUNX2 regulates bone development"], "367242": ["RAB geranylgeranylation"], "367252": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation", "N-Glycan antennae elongation"], "367264": ["Interleukin-6 signaling", "ISG15 antiviral mechanism", "Signaling by SCF-KIT", "Downstream signal transduction", "Interleukin-4 and Interleukin-13 signaling", "Interferon gamma signaling", "Regulation of IFNG signaling", "Interleukin-20 family signaling", "Interleukin-35 Signalling", "Interleukin-9 signaling", "Interleukin-27 signaling", "Interleukin-21 signaling", "Interferon alpha/beta signaling", "Regulation of IFNA signaling"], "367302": ["Phase 3 - rapid repolarisation", "Phase 2 - plateau phase"], "367315": ["Class A/1 (Rhodopsin-like receptors)"], "367316": ["Passive transport by Aquaporins"], "367318": ["Stimuli-sensing channels"], "367323": ["Nicotinamide salvaging"], "367384": ["O-linked glycosylation of mucins"], "367455": ["Neutrophil degranulation"], "367562": ["Neutrophil degranulation", "Glycogen breakdown (glycogenolysis)"], "367747": ["Synthesis of pyrophosphates in the cytosol"], "367808": ["Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "HSF1 activation", "Attenuation phase", "Aryl hydrocarbon receptor signalling", "ESR-mediated signaling", "Estrogen-dependent gene expression"], "367912": ["Neurotransmitter receptors and postsynaptic signal transmission"], "367915": ["Neutrophil degranulation", "Retrograde transport at the Trans-Golgi-Network", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "368002": ["B-WICH complex positively regulates rRNA expression", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"], "368044": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "368084": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "368158": ["Nuclear Receptor transcription pathway"], "373540": ["Interleukin-18 signaling"], "373541": ["RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "373545": ["Macroautophagy", "AMPK inhibits chREBP transcriptional activation activity", "Import of palmitoyl-CoA into the mitochondrial matrix", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Regulation of TP53 Activity through Phosphorylation"], "378939": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "379044": ["Orexin and neuropeptides FF and QRFP bind to their respective receptors", "G alpha (q) signalling events"], "394266": ["Transport of connexons to the plasma membrane"], "399475": ["G alpha (s) signalling events", "Calcitonin-like ligand receptors"], "399489": ["CDC6 association with the ORC:origin complex", "G2 Phase", "Cyclin D associated events in G1"], "404280": ["Import of palmitoyl-CoA into the mitochondrial matrix"], "404789": ["Olfactory Signaling Pathway"], "404794": ["Olfactory Signaling Pathway"], "404797": ["Olfactory Signaling Pathway"], "404808": ["Olfactory Signaling Pathway"], "404809": ["Olfactory Signaling Pathway"], "404810": ["Olfactory Signaling Pathway"], "404813": ["Olfactory Signaling Pathway"], "404814": ["Olfactory Signaling Pathway"], "404815": ["Olfactory Signaling Pathway"], "404816": ["Olfactory Signaling Pathway"], "404817": ["Olfactory Signaling Pathway"], "404818": ["Olfactory Signaling Pathway"], "404820": ["Olfactory Signaling Pathway"], "404824": ["Olfactory Signaling Pathway"], "404825": ["Olfactory Signaling Pathway"], "404826": ["Olfactory Signaling Pathway"], "404827": ["Olfactory Signaling Pathway"], "404828": ["Olfactory Signaling Pathway"], "404832": ["Olfactory Signaling Pathway"], "404833": ["Olfactory Signaling Pathway"], "404834": ["Olfactory Signaling Pathway"], "404839": ["Olfactory Signaling Pathway"], "404853": ["Olfactory Signaling Pathway"], "404855": ["Olfactory Signaling Pathway"], "404858": ["Olfactory Signaling Pathway"], "404859": ["Olfactory Signaling Pathway"], "404861": ["Olfactory Signaling Pathway"], "404862": ["Olfactory Signaling Pathway"], "404863": ["Olfactory Signaling Pathway"], "404866": ["Olfactory Signaling Pathway"], "404871": ["Olfactory Signaling Pathway"], "404875": ["Olfactory Signaling Pathway"], "404877": ["Olfactory Signaling Pathway"], "404878": ["Olfactory Signaling Pathway"], "404880": ["Olfactory Signaling Pathway"], "404881": ["Olfactory Signaling Pathway"], "404882": ["Olfactory Signaling Pathway"], "404884": ["Olfactory Signaling Pathway"], "404885": ["Olfactory Signaling Pathway"], "404887": ["Olfactory Signaling Pathway"], "404888": ["Olfactory Signaling Pathway"], "404891": ["Olfactory Signaling Pathway"], "404892": ["Olfactory Signaling Pathway"], "404894": ["Olfactory Signaling Pathway"], "404895": ["Olfactory Signaling Pathway"], "404896": ["Olfactory Signaling Pathway"], "404897": ["Olfactory Signaling Pathway"], "404898": ["Olfactory Signaling Pathway"], "404899": ["Olfactory Signaling Pathway"], "404901": ["Olfactory Signaling Pathway"], "404943": ["Olfactory Signaling Pathway"], "404948": ["Olfactory Signaling Pathway"], "404958": ["Olfactory Signaling Pathway"], "404959": ["Olfactory Signaling Pathway"], "404960": ["Olfactory Signaling Pathway"], "404961": ["Olfactory Signaling Pathway"], "404967": ["Olfactory Signaling Pathway"], "404968": ["Olfactory Signaling Pathway"], "404971": ["Olfactory Signaling Pathway"], "404972": ["Olfactory Signaling Pathway"], "404976": ["Olfactory Signaling Pathway"], "404980": ["Olfactory Signaling Pathway"], "404981": ["Olfactory Signaling Pathway"], "404983": ["Olfactory Signaling Pathway"], "404984": ["Olfactory Signaling Pathway"], "404986": ["Olfactory Signaling Pathway"], "404988": ["Olfactory Signaling Pathway"], "404989": ["Olfactory Signaling Pathway"], "404995": ["Olfactory Signaling Pathway"], "404998": ["Olfactory Signaling Pathway"], "404999": ["Olfactory Signaling Pathway"], "405003": ["Olfactory Signaling Pathway"], "405023": ["Olfactory Signaling Pathway"], "405025": ["Olfactory Signaling Pathway"], "405026": ["Olfactory Signaling Pathway"], "405027": ["Olfactory Signaling Pathway"], "405030": ["Olfactory Signaling Pathway"], "405031": ["Olfactory Signaling Pathway"], "405034": ["Olfactory Signaling Pathway"], "405036": ["Olfactory Signaling Pathway"], "405048": ["Olfactory Signaling Pathway"], "405049": ["Olfactory Signaling Pathway"], "405050": ["Olfactory Signaling Pathway"], "405051": ["Olfactory Signaling Pathway"], "405053": ["Olfactory Signaling Pathway"], "405056": ["Olfactory Signaling Pathway"], "405057": ["Olfactory Signaling Pathway"], "405064": ["Olfactory Signaling Pathway"], "405065": ["Olfactory Signaling Pathway"], "405085": ["Olfactory Signaling Pathway"], "405086": ["Olfactory Signaling Pathway"], "405099": ["Olfactory Signaling Pathway"], "405105": ["Olfactory Signaling Pathway"], "405106": ["Olfactory Signaling Pathway"], "405107": ["Olfactory Signaling Pathway"], "405108": ["Olfactory Signaling Pathway"], "405112": ["Olfactory Signaling Pathway"], "405114": ["Olfactory Signaling Pathway"], "405115": ["Olfactory Signaling Pathway"], "405121": ["Olfactory Signaling Pathway"], "405122": ["Olfactory Signaling Pathway"], "405123": ["Olfactory Signaling Pathway"], "405125": ["Olfactory Signaling Pathway"], "405126": ["Olfactory Signaling Pathway"], "405131": ["Olfactory Signaling Pathway"], "405133": ["Olfactory Signaling Pathway"], "405134": ["Olfactory Signaling Pathway"], "405136": ["Olfactory Signaling Pathway"], "405137": ["Olfactory Signaling Pathway"], "405138": ["Olfactory Signaling Pathway"], "405140": ["Olfactory Signaling Pathway"], "405141": ["Olfactory Signaling Pathway"], "405144": ["Olfactory Signaling Pathway"], "405148": ["Olfactory Signaling Pathway"], "405150": ["Olfactory Signaling Pathway"], "405155": ["Olfactory Signaling Pathway"], "405158": ["Olfactory Signaling Pathway"], "405164": ["Olfactory Signaling Pathway"], "405166": ["Olfactory Signaling Pathway"], "405171": ["Olfactory Signaling Pathway"], "405172": ["Olfactory Signaling Pathway"], "405174": ["Olfactory Signaling Pathway"], "405175": ["Olfactory Signaling Pathway"], "405177": ["Olfactory Signaling Pathway"], "405178": ["Olfactory Signaling Pathway"], "405179": ["Olfactory Signaling Pathway"], "405180": ["Olfactory Signaling Pathway"], "405181": ["Olfactory Signaling Pathway"], "405182": ["Olfactory Signaling Pathway"], "405183": ["Olfactory Signaling Pathway"], "405185": ["Olfactory Signaling Pathway"], "405201": ["Olfactory Signaling Pathway"], "405203": ["Olfactory Signaling Pathway"], "405218": ["Olfactory Signaling Pathway"], "405219": ["Olfactory Signaling Pathway"], "405221": ["Olfactory Signaling Pathway"], "405222": ["Olfactory Signaling Pathway"], "405233": ["Olfactory Signaling Pathway"], "405238": ["Olfactory Signaling Pathway"], "405239": ["Olfactory Signaling Pathway"], "405242": ["Olfactory Signaling Pathway"], "405245": ["Olfactory Signaling Pathway"], "405248": ["Olfactory Signaling Pathway"], "405249": ["Olfactory Signaling Pathway"], "405251": ["Olfactory Signaling Pathway"], "405252": ["Olfactory Signaling Pathway"], "405253": ["Olfactory Signaling Pathway"], "405255": ["Olfactory Signaling Pathway"], "405258": ["Olfactory Signaling Pathway"], "405277": ["Olfactory Signaling Pathway"], "405280": ["Olfactory Signaling Pathway"], "405285": ["Olfactory Signaling Pathway"], "405287": ["Olfactory Signaling Pathway"], "405293": ["Olfactory Signaling Pathway"], "405297": ["Olfactory Signaling Pathway"], "405303": ["Olfactory Signaling Pathway"], "405305": ["Olfactory Signaling Pathway"], "405307": ["Olfactory Signaling Pathway"], "405325": ["Olfactory Signaling Pathway"], "405326": ["Olfactory Signaling Pathway"], "405329": ["Olfactory Signaling Pathway"], "405331": ["Olfactory Signaling Pathway"], "405333": ["Olfactory Signaling Pathway"], "405334": ["Olfactory Signaling Pathway"], "405337": ["Olfactory Signaling Pathway"], "405339": ["Olfactory Signaling Pathway"], "405344": ["Olfactory Signaling Pathway"], "405349": ["Olfactory Signaling Pathway"], "405352": ["Olfactory Signaling Pathway"], "405357": ["Olfactory Signaling Pathway"], "405362": ["Olfactory Signaling Pathway"], "405363": ["Olfactory Signaling Pathway"], "405365": ["Olfactory Signaling Pathway"], "405366": ["Olfactory Signaling Pathway"], "405368": ["Olfactory Signaling Pathway"], "405373": ["Olfactory Signaling Pathway"], "405383": ["Olfactory Signaling Pathway"], "405390": ["Olfactory Signaling Pathway"], "405392": ["Olfactory Signaling Pathway"], "405393": ["Olfactory Signaling Pathway"], "405398": ["Olfactory Signaling Pathway"], "405904": ["Olfactory Signaling Pathway"], "405911": ["Olfactory Signaling Pathway"], "405912": ["Olfactory Signaling Pathway"], "405914": ["Olfactory Signaling Pathway"], "405915": ["Olfactory Signaling Pathway"], "405917": ["Olfactory Signaling Pathway"], "405918": ["Olfactory Signaling Pathway"], "405919": ["Olfactory Signaling Pathway"], "405920": ["Olfactory Signaling Pathway"], "405921": ["Olfactory Signaling Pathway"], "405923": ["Olfactory Signaling Pathway"], "405927": ["Olfactory Signaling Pathway"], "405928": ["Olfactory Signaling Pathway"], "405934": ["Olfactory Signaling Pathway"], "405935": ["Olfactory Signaling Pathway"], "405940": ["Olfactory Signaling Pathway"], "405948": ["Olfactory Signaling Pathway"], "405950": ["Olfactory Signaling Pathway"], "405952": ["Olfactory Signaling Pathway"], "405954": ["Olfactory Signaling Pathway"], "405955": ["Olfactory Signaling Pathway"], "405963": ["Olfactory Signaling Pathway"], "405964": ["Olfactory Signaling Pathway"], "405966": ["Olfactory Signaling Pathway"], "405969": ["Olfactory Signaling Pathway"], "405971": ["Olfactory Signaling Pathway"], "405982": ["Olfactory Signaling Pathway"], "405983": ["Olfactory Signaling Pathway"], "405993": ["Olfactory Signaling Pathway"], "406001": ["Olfactory Signaling Pathway"], "406002": ["Olfactory Signaling Pathway"], "406003": ["Olfactory Signaling Pathway"], "406004": ["Olfactory Signaling Pathway"], "406018": ["Olfactory Signaling Pathway"], "406021": ["Olfactory Signaling Pathway"], "406039": ["Olfactory Signaling Pathway"], "406161": ["Initial triggering of complement", "Activation of C3 and C5", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation", "Regulation of Complement cascade"], "406162": ["Pre-NOTCH Processing in Golgi", "Notch-HLH transcription pathway", "NOTCH4 Activation and Transmission of Signal to the Nucleus", "Negative regulation of NOTCH4 signaling"], "406163": ["G alpha (i) signalling events"], "406165": ["Synthesis of PA", "ChREBP activates metabolic gene expression"], "406168": ["The role of GTSE1 in G2/M progression after G2 checkpoint"], "406226": ["Keratinization", "Formation of the cornified envelope"], "406227": ["Keratinization", "Formation of the cornified envelope"], "406230": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "406865": ["GPVI-mediated activation cascade"], "407757": ["Keratinization", "Formation of the cornified envelope"], "407758": ["Keratinization", "Formation of the cornified envelope"], "407759": ["Keratinization", "Formation of the cornified envelope"], "407760": ["Keratinization", "Formation of the cornified envelope"], "407761": ["Keratinization", "Formation of the cornified envelope"], "407762": ["Keratinization", "Formation of the cornified envelope"], "407764": ["Sialic acid metabolism", "Termination of O-glycan biosynthesis"], "407765": ["Sialic acid metabolism"], "407784": ["ABC-family proteins mediated transport", "ER Quality Control Compartment (ERQC)"], "408030": ["Olfactory Signaling Pathway"], "408200": ["Deadenylation of mRNA"], "408201": ["Collagen degradation", "Degradation of the extracellular matrix", "Trafficking and processing of endosomal TLR", "Assembly of collagen fibrils and other multimeric structures", "MHC class II antigen presentation", "RUNX1 regulates transcription of genes involved in differentiation of keratinocytes"], "408206": ["Aflatoxin activation and detoxification"], "408214": ["Formation of the cornified envelope"], "408215": ["Formation of the cornified envelope"], "408217": ["Ub-specific processing proteases"], "408218": ["Degradation of the extracellular matrix"], "408224": ["Neutrophil degranulation"], "408229": ["Neutrophil degranulation"], "408235": ["Formation of the cornified envelope"], "408242": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "408243": ["Peptide ligand-binding receptors"], "408248": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "414783": ["ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "414785": ["ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "414792": ["ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "414793": ["ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "415062": ["Post-translational modification: synthesis of GPI-anchored proteins"], "432367": ["Intestinal lipid absorption"], "432392": ["Reactions specific to the complex N-glycan synthesis pathway"], "436582": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "444984": ["PRC2 methylates histones and DNA", "RMTs methylate histone arginines"], "444985": ["PRC2 methylates histones and DNA", "SUMOylation of DNA methylation proteins"], "444986": ["Interleukin-20 family signaling"], "445269": ["Peptide ligand-binding receptors", "Regulation of Complement cascade"], "445371": ["TWIK-related spinal cord K+ channel (TRESK)", "Phase 4 - resting membrane potential"], "445415": ["Neutrophil degranulation"], "450224": ["Axonal growth inhibition (RHOA activation)"], "450225": ["Keratinization", "Formation of the cornified envelope"], "450229": ["Keratinization", "Formation of the cornified envelope"], "450230": ["Keratinization", "Formation of the cornified envelope"], "474146": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "474147": ["Antigen processing: Ubiquitination & Proteasome degradation"], "474169": ["Neutrophil degranulation", "Antimicrobial peptides"], "474348": ["O-glycosylation of TSR domain-containing proteins"], "492821": ["Activation of NOXA and translocation to mitochondria", "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members"], "493810": ["MHC class II antigen presentation", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic", "Advanced glycosylation endproduct receptor signaling", "Factors involved in megakaryocyte development and platelet production"], "494021": ["Surfactant metabolism"], "494223": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "494342": ["N-Glycan antennae elongation"], "494445": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "mRNA 3'-end processing"], "494499": ["Glutathione conjugation"], "497009": ["Neurotransmitter release cycle"], "497078": ["Peptide ligand-binding receptors"], "497195": ["Neutrophil degranulation", "Antimicrobial peptides"], "497196": ["Peptide ligand-binding receptors", "G alpha (q) signalling events", "G alpha (i) signalling events"], "497197": ["Synthesis of IP3 and IP4 in the cytosol"], "497229": ["Adherens junctions interactions"], "497672": ["SUMOylation of DNA damage response and repair proteins", "HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Metalloprotease DUBs", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Nonhomologous End-Joining (NHEJ)", "Homologous DNA Pairing and Strand Exchange", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "G2/M DNA damage checkpoint"], "497770": ["Phase 0 - rapid depolarisation"], "497778": ["Interconversion of nucleotide di- and triphosphates"], "497815": ["Neurofascin interactions"], "497840": ["Urea cycle"], "497856": ["HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange"], "497860": ["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "497876": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "497897": ["Generic Transcription Pathway"], "497913": ["Gap junction assembly"], "497923": ["Generic Transcription Pathway"], "497931": ["GPVI-mediated activation cascade", "Synthesis of PIPs at the plasma membrane", "G beta:gamma signalling through PI3Kgamma", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)"], "497932": ["GPVI-mediated activation cascade", "Synthesis of PIPs at the plasma membrane", "G beta:gamma signalling through PI3Kgamma"], "497942": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "497948": ["TRP channels"], "497958": ["snRNP Assembly"], "497961": ["Ca2+ pathway"], "497967": ["Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER"], "497978": ["Effects of PIP2 hydrolysis"], "497991": ["Nuclear Receptor transcription pathway", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)", "Estrogen-dependent gene expression"], "497995": ["Keratinization"], "498003": ["ERKs are inactivated"], "498005": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "498011": ["Cross-presentation of soluble exogenous antigens (endosomes)"], "498013": ["IRE1alpha activates chaperones"], "498030": ["Inactivation of APC/C via direct inhibition of the APC/C complex", "APC/C:Cdc20 mediated degradation of Cyclin B", "Autodegradation of Cdh1 by Cdh1:APC/C", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of the APC/C", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Senescence-Associated Secretory Phenotype (SASP)", "CDK-mediated phosphorylation and removal of Cdc6", "Antigen processing: Ubiquitination & Proteasome degradation"], "498034": ["Gamma carboxylation, hypusine formation and arylsulfatase activation"], "498072": ["Activation of DNA fragmentation factor"], "498075": ["PIP3 activates AKT signaling", "Downstream TCR signaling", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "498079": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "498089": ["Antigen processing: Ubiquitination & Proteasome degradation"], "498095": ["Intraflagellar transport"], "498109": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase I Transcription Termination", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Pol II CTD phosphorylation and interaction with CE", "Estrogen-dependent gene expression"], "498119": ["Resolution of D-loop Structures through Holliday Junction Intermediates"], "498160": ["Generic Transcription Pathway"], "498169": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "498183": ["Oxidative Stress Induced Senescence", "MAPK6/MAPK4 signaling", "Regulation of TP53 Activity through Phosphorylation"], "498185": ["Sodium/Calcium exchangers", "Mitochondrial calcium ion transport"], "498206": ["TNFR2 non-canonical NF-kB pathway", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "498209": ["Neutrophil degranulation"], "498233": ["Regulation of FZD by ubiquitination"], "498234": ["Neutrophil degranulation"], "498241": ["Regulation of Complement cascade"], "498246": ["G alpha (q) signalling events", "G alpha (i) signalling events"], "498251": ["mRNA Editing: C to U Conversion", "Formation of the Editosome"], "498266": ["Golgi Cisternae Pericentriolar Stack Reorganization"], "498272": ["Synthesis of UDP-N-acetyl-glucosamine"], "498276": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "FCGR activation", "Regulation of actin dynamics for phagocytic cup formation", "Role of phospholipids in phagocytosis", "Neutrophil degranulation"], "498281": ["Adherens junctions interactions", "Nectin/Necl  trans heterodimerization"], "498282": ["Rho GTPase cycle"], "498287": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "498289": ["G alpha (i) signalling events", "Opsins"], "498299": ["Platelet degranulation "], "498310": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "498328": ["VxPx cargo-targeting to cilium"], "498331": ["Synthesis of PIPs at the plasma membrane"], "498335": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "498406": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "498411": ["Activation of ATR in response to replication stress", "HDR through Single Strand Annealing (SSA)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange"], "498416": ["Signaling by SCF-KIT", "IRS activation", "Signal attenuation", "Insulin receptor signalling cascade", "RET signaling"], "498425": ["mRNA Splicing - Minor Pathway"], "498433": ["UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "498453": ["Formation of RNA Pol II elongation complex ", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "RNA Polymerase II Transcription Elongation"], "498486": ["Synthesis of UDP-N-acetyl-glucosamine"], "498515": ["Adherens junctions interactions"], "498559": ["Neddylation"], "498576": ["MAP2K and MAPK activation"], "498638": ["Scavenging by Class A Receptors"], "498659": ["Defensins", "Alpha-defensins", "Neutrophil degranulation"], "498666": ["TNFR2 non-canonical NF-kB pathway", "TNFs bind their physiological receptors", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "498688": ["Collagen degradation", "Degradation of the extracellular matrix", "Trafficking and processing of endosomal TLR", "Assembly of collagen fibrils and other multimeric structures", "MHC class II antigen presentation", "RUNX1 regulates transcription of genes involved in differentiation of keratinocytes"], "498691": ["Collagen degradation", "Degradation of the extracellular matrix", "Trafficking and processing of endosomal TLR", "Assembly of collagen fibrils and other multimeric structures", "MHC class II antigen presentation", "RUNX1 regulates transcription of genes involved in differentiation of keratinocytes"], "498726": ["Antigen processing: Ubiquitination & Proteasome degradation"], "498728": ["Linoleic acid (LA) metabolism", "alpha-linolenic acid (ALA) metabolism", "Synthesis of very long-chain fatty acyl-CoAs"], "498736": ["Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Recruitment of NuMA to mitotic centrosomes", "Recycling pathway of L1", "Hedgehog 'off' state", "Cilium Assembly", "Intraflagellar transport", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "Carboxyterminal post-translational modifications of tubulin", "Kinesins"], "498741": ["Acyl chain remodelling of PS", "Acyl chain remodelling of PE"], "498769": ["TNFs bind their physiological receptors"], "498790": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "RA biosynthesis pathway", "Retinoid metabolism and transport"], "498798": ["EGFR downregulation", "Metalloprotease DUBs", "Negative regulation of MET activity", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "498840": ["STING mediated induction of host immune responses", "Regulation of innate immune responses to cytosolic DNA", "STAT6-mediated induction of chemokines", "IRF3-mediated induction of type I IFN", "Neutrophil degranulation"], "498854": ["Scavenging by Class A Receptors"], "498888": ["DAP12 interactions"], "498898": ["RET signaling"], "498934": ["mRNA decay by 5' to 3' exoribonuclease", "mRNA Splicing - Major Pathway"], "498940": ["Phase I - Functionalization of compounds"], "498941": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "498945": ["Generic Transcription Pathway"], "498951": ["Other interleukin signaling"], "498959": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "498962": ["Synthesis of very long-chain fatty acyl-CoAs"], "498988": ["Activation of DNA fragmentation factor"], "498992": ["Post-translational modification: synthesis of GPI-anchored proteins"], "498997": ["Regulation of FZD by ubiquitination"], "498999": ["Phase I - Functionalization of compounds", "Endogenous sterols", "Xenobiotics", "Aryl hydrocarbon receptor signalling"], "499016": ["Neddylation"], "499020": ["Processing of Capped Intron-Containing Pre-mRNA"], "499099": ["Common Pathway of Fibrin Clot Formation", "Neutrophil degranulation"], "499124": ["Generic Transcription Pathway"], "499132": ["Inactivation, recovery and regulation of the phototransduction cascade"], "499147": ["Sperm:Oocyte Membrane Binding"], "499149": ["Class B/2 (Secretin family receptors)", "G alpha (s) signalling events"], "499152": ["Sperm:Oocyte Membrane Binding"], "499156": ["Caspase-mediated cleavage of cytoskeletal proteins"], "499157": ["Neutrophil degranulation"], "499174": ["Sphingolipid de novo biosynthesis"], "499185": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "499194": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "499210": ["Sphingolipid de novo biosynthesis"], "499241": ["Release of Hh-Np from the secreting cell"], "499260": ["Post-translational modification: synthesis of GPI-anchored proteins"], "499264": ["VLDL clearance"], "499271": ["Cell surface interactions at the vascular wall", "Integrin cell surface interactions", "ECM proteoglycans", "Neutrophil degranulation"], "499285": ["Degradation of the extracellular matrix", "Neutrophil degranulation"], "499303": ["Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)", "Phase 4 - resting membrane potential"], "499308": ["Downstream signaling of activated FGFR1"], "499328": ["Vitamin B2 (riboflavin) metabolism"], "499330": ["Nicotinate metabolism"], "499337": ["Factors involved in megakaryocyte development and platelet production"], "499342": ["PD-1 signaling"], "499345": ["Formation of the cornified envelope"], "499349": ["FGFR2b ligand binding and activation"], "499353": ["Xenobiotics"], "499356": ["Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "499358": ["Fatty acyl-CoA biosynthesis"], "499391": ["snRNP Assembly"], "499400": ["ER-Phagosome pathway", "Endosomal/Vacuolar pathway", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "499415": ["Costimulation by the CD28 family"], "499417": ["SUMO is proteolytically processed", "SUMOylation of DNA damage response and repair proteins", "SUMOylation of transcription factors", "SUMOylation of transcription cofactors", "SUMOylation of intracellular receptors", "SUMOylation of chromatin organization proteins", "SUMOylation of DNA replication proteins", "SUMOylation of immune response proteins", "Formation of Incision Complex in GG-NER"], "499431": ["Collagen degradation", "Collagen biosynthesis and modifying enzymes", "Integrin cell surface interactions", "Collagen chain trimerization"], "499443": ["Regulation of cytoskeletal remodeling and cell spreading by IPP complex components"], "499462": ["Cellular hexose transport"], "499474": ["Stimuli-sensing channels"], "499486": ["G alpha (s) signalling events"], "499497": ["CDO in myogenesis"], "499505": ["Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)"], "499508": ["Signaling by BMP"], "499529": ["Respiratory electron transport", "Complex I biogenesis"], "499537": ["Generation of second messenger molecules", "Signal regulatory protein family interactions"], "499566": ["Reversible hydration of carbon dioxide"], "499570": ["Triglyceride catabolism"], "499593": ["Deactivation of the beta-catenin transactivating complex"], "499655": ["SCF(Skp2)-mediated degradation of p27/p21", "Cyclin D associated events in G1"], "499658": ["Antimicrobial peptides"], "499689": ["Glutathione conjugation", "Biosynthesis of maresin conjugates in tissue regeneration (MCTR)"], "499744": ["Interleukin-36 pathway"], "499768": ["TBC/RABGAPs"], "499801": ["Ub-specific processing proteases"], "499807": ["Neddylation"], "499870": ["HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange", "Presynaptic phase of homologous DNA pairing and strand exchange"], "499874": ["Transcriptional Regulation by E2F6"], "499878": ["Synthesis of pyrophosphates in the cytosol"], "499883": ["Transcriptional activation of mitochondrial biogenesis"], "499900": ["Generic Transcription Pathway"], "499903": ["COPII-mediated vesicle transport", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network"], "499913": ["Arachidonate production from DAG"], "499914": ["Unwinding of DNA"], "499918": ["Regulation of FZD by ubiquitination"], "499925": ["Antimicrobial peptides"], "499926": ["Antimicrobial peptides"], "499929": ["Downregulation of SMAD2/3:SMAD4 transcriptional activity"], "499933": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Neutrophil degranulation", "Mitotic Prometaphase"], "499951": ["Factors involved in megakaryocyte development and platelet production"], "499956": ["Pyrimidine salvage"], "499966": ["HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange", "Presynaptic phase of homologous DNA pairing and strand exchange"], "499968": ["O-linked glycosylation of mucins"], "499972": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "499973": ["Macroautophagy"], "499974": ["Transport of Mature mRNA derived from an Intron-Containing Transcript", "SUMOylation of DNA damage response and repair proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of DNA replication proteins"], "500006": ["Peroxisomal protein import"], "500047": ["WNT ligand biogenesis and trafficking"], "500050": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "500052": ["Interaction With Cumulus Cells"], "500054": ["DNA Damage/Telomere Stress Induced Senescence"], "500069": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "500086": ["Intraflagellar transport"], "500088": ["RAB geranylgeranylation"], "500089": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "500091": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "500101": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "500108": ["Generic Transcription Pathway"], "500132": ["Synthesis of PIPs at the plasma membrane"], "500133": ["NOD1/2 Signaling Pathway", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "Ovarian tumor domain proteases", "Interleukin-1 signaling"], "500152": ["Platelet degranulation "], "500157": ["Orexin and neuropeptides FF and QRFP bind to their respective receptors", "G alpha (q) signalling events"], "500219": ["Neurexins and neuroligins"], "500221": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "500225": ["UCH proteinases", "DNA Damage Recognition in GG-NER"], "500244": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "500246": ["Rho GTPase cycle"], "500249": ["Retrograde transport at the Trans-Golgi-Network", "RAB geranylgeranylation"], "500251": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "500257": ["Chondroitin sulfate biosynthesis"], "500262": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "500287": ["Rho GTPase cycle"], "500292": ["Lipid particle organization"], "500304": ["Generic Transcription Pathway"], "500305": ["mRNA decay by 5' to 3' exoribonuclease"], "500317": ["G alpha (q) signalling events", "G alpha (i) signalling events", "Lysosphingolipid and LPA receptors"], "500318": ["TNFs bind their physiological receptors"], "500336": ["GPVI-mediated activation cascade"], "500338": ["DAP12 interactions", "DAP12 signaling"], "500350": ["Formation of ATP by chemiosmotic coupling", "Cristae formation"], "500351": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "SUMOylation of chromatin organization proteins", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "500367": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "500368": ["Wax biosynthesis"], "500377": ["Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Recruitment of NuMA to mitotic centrosomes", "Recycling pathway of L1", "Cilium Assembly", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "Carboxyterminal post-translational modifications of tubulin", "Kinesins"], "500378": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA 3'-end processing"], "500409": ["FGFR2 alternative splicing"], "500450": ["Striated Muscle Contraction", "Smooth Muscle Contraction"], "500460": ["Olfactory Signaling Pathway"], "500485": ["Signaling by BMP"], "500491": ["Interferon alpha/beta signaling", "Regulation of IFNA signaling"], "500511": ["Antigen processing: Ubiquitination & Proteasome degradation"], "500526": ["Spry regulation of FGF signaling"], "500538": ["mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "Noncanonical activation of NOTCH3"], "500545": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA replication proteins", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "500571": ["Intraflagellar transport"], "500572": ["Ovarian tumor domain proteases", "Regulation of PTEN stability and activity"], "500587": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "500590": ["TNFs bind their physiological receptors"], "500592": ["TNFs bind their physiological receptors"], "500608": ["NRAGE signals death through JNK", "Rho GTPase cycle"], "500616": ["Interleukin-4 and Interleukin-13 signaling", "Neddylation"], "500629": ["RA biosynthesis pathway"], "500651": ["Sphingolipid de novo biosynthesis"], "500666": ["Degradation of DVL"], "500694": ["Mitochondrial iron-sulfur cluster biogenesis"], "500695": ["NOTCH1 Intracellular Domain Regulates Transcription", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Notch-HLH transcription pathway", "mRNA Splicing - Major Pathway", "RUNX3 regulates NOTCH signaling"], "500709": ["Synthesis of pyrophosphates in the cytosol", "Synthesis of IP3 and IP4 in the cytosol", "Factors involved in megakaryocyte development and platelet production"], "500715": ["Formation of RNA Pol II elongation complex ", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Transcription Elongation"], "500801": ["Fatty acids", "Miscellaneous substrates", "Eicosanoids", "Synthesis of Leukotrienes (LT) and Eoxins (EX)"], "500820": ["Nicotinamide salvaging", "Organic anion transporters"], "500836": ["Interleukin-20 family signaling"], "500863": ["Regulation of FZD by ubiquitination"], "500901": ["Rho GTPase cycle"], "500904": ["Cross-presentation of particulate exogenous antigens (phagosomes)", "Detoxification of Reactive Oxygen Species", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate NADPH Oxidases"], "500906": ["Intra-Golgi traffic"], "500910": ["TNFR2 non-canonical NF-kB pathway", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway"], "500929": ["Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Recruitment of NuMA to mitotic centrosomes", "Recycling pathway of L1", "Hedgehog 'off' state", "Cilium Assembly", "Intraflagellar transport", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "Carboxyterminal post-translational modifications of tubulin", "Kinesins"], "500943": ["Rho GTPase cycle"], "500950": ["Generic Transcription Pathway"], "500973": ["Gluconeogenesis"], "500981": ["Generic Transcription Pathway"], "500985": ["Interleukin-6 signaling", "Spry regulation of FGF signaling", "Regulation of KIT signaling", "EGFR downregulation", "TGF-beta receptor signaling activates SMADs", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "Negative regulation of MET activity", "PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "Regulation of signaling by CBL"], "500987": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "500988": ["mRNA decay by 5' to 3' exoribonuclease"], "501028": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "501043": ["Interleukin-20 family signaling"], "501059": ["COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "501099": ["RHO GTPases Activate Formins"], "501103": ["Transport and synthesis of PAPS", "Transport of nucleotide sugars"], "501145": ["SUMOylation of chromatin organization proteins"], "501146": ["Energy dependent regulation of mTOR by LKB1-AMPK"], "501157": ["Pentose phosphate pathway"], "501177": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (i) signalling events"], "501203": ["Ephrin signaling", "Smooth Muscle Contraction"], "501454": ["Regulation of ornithine decarboxylase (ODC)"], "501502": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "501515": ["Deadenylation of mRNA"], "501550": ["COPII-mediated vesicle transport", "RAB GEFs exchange GTP for GDP on RABs"], "501552": ["Fanconi Anemia Pathway"], "501560": ["ERK/MAPK targets", "CREB phosphorylation", "Senescence-Associated Secretory Phenotype (SASP)", "CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling", "RSK activation", "Gastrin-CREB signalling pathway via PKC and MAPK"], "501582": ["Eukaryotic Translation Termination", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "501584": ["Degradation of beta-catenin by the destruction complex", "Beta-catenin phosphorylation cascade"], "501621": ["Transport of Mature mRNA derived from an Intron-Containing Transcript"], "501688": ["Cleavage of Growing Transcript in the Termination Region ", "SLBP independent Processing of Histone Pre-mRNAs", "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"], "501706": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "501720": ["Keratinization"], "501721": ["Keratinization"], "501725": ["Keratinization"], "501765": ["Keratinization"], "501779": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "501797": ["CD209 (DC-SIGN) signaling", "Butyrophilin (BTN) family interactions"], "501854": ["TBC/RABGAPs", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "501869": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "501872": ["Cell surface interactions at the vascular wall"], "501907": ["Glucuronidation"], "501925": ["Cellular hexose transport"], "501926": ["mRNA Splicing - Minor Pathway"], "501996": ["Interleukin-17 signaling"], "502017": ["Synthesis of dolichyl-phosphate mannose"], "502097": ["Negative regulation of TCF-dependent signaling by WNT ligand antagonists"], "502129": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Metalloprotease DUBs", "Deposition of new CENPA-containing nucleosomes at the centromere", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "502227": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "mRNA Capping", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase I Transcription Termination", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE"], "502308": ["Post-translational modification: synthesis of GPI-anchored proteins"], "502316": ["Generic Transcription Pathway"], "502320": ["Fanconi Anemia Pathway"], "502348": ["Recycling of bile acids and salts"], "502603": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing"], "502694": ["RET signaling"], "502749": ["Glycerophospholipid biosynthesis"], "502755": ["Olfactory Signaling Pathway"], "502758": ["Olfactory Signaling Pathway"], "502764": ["Generic Transcription Pathway"], "502852": ["Cross-presentation of soluble exogenous antigens (endosomes)"], "502858": ["Intrinsic Pathway of Fibrin Clot Formation", "GP1b-IX-V activation signalling", "Platelet Adhesion to exposed collagen", "Platelet Aggregation (Plug Formation)"], "502894": ["TP53 Regulates Metabolic Genes"], "502902": ["CLEC7A (Dectin-1) signaling"], "502913": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "SUMOylation of chromatin organization proteins", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "502966": ["Interferon alpha/beta signaling", "Regulation of IFNA signaling"], "502969": ["Fatty acids", "Xenobiotics", "Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)"], "502970": ["Assembly of active LPL and LIPC lipase complexes"], "502988": ["TP53 Regulates Metabolic Genes"], "502990": ["Miscellaneous transport and binding events"], "503000": ["Deactivation of the beta-catenin transactivating complex"], "503018": ["Hedgehog 'off' state", "Intraflagellar transport"], "503049": ["Mitochondrial Fatty Acid Beta-Oxidation", "Peroxisomal protein import"], "503103": ["Cytosolic sulfonation of small molecules"], "503164": ["Scavenging of heme from plasma", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "503446": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "503568": ["Sodium-coupled sulphate, di- and tri-carboxylate transporters"], "50549": ["Fatty acids", "Miscellaneous substrates", "Eicosanoids", "Synthesis of Leukotrienes (LT) and Eoxins (EX)", "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)"], "50555": ["Glycosphingolipid metabolism"], "50557": ["Synthesis of PIPs at the plasma membrane", "Synthesis of IP3 and IP4 in the cytosol", "Negative regulation of the PI3K/AKT network", "Downstream TCR signaling", "Ub-specific processing proteases", "Ovarian tumor domain proteases", "Regulation of PTEN localization", "Regulation of PTEN stability and activity"], "50558": ["Antigen processing: Ubiquitination & Proteasome degradation"], "50560": ["Synthesis of pyrophosphates in the cytosol", "Synthesis of IPs in the nucleus"], "50563": ["Gap junction assembly"], "50564": ["Electric Transmission Across Gap Junctions", "Gap junction assembly"], "50567": ["Basigin interactions", "Amino acid transport across the plasma membrane", "Tryptophan catabolism"], "50572": ["Recycling of bile acids and salts", "Transport of organic anions"], "50577": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "50585": ["Antimicrobial peptides"], "50599": ["Activation of G protein gated Potassium channels", "Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "50621": ["Vitamin C (ascorbate) metabolism"], "50622": ["Vitamin C (ascorbate) metabolism"], "50645": ["Neutrophil degranulation", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "50646": ["Signal regulatory protein family interactions", "VEGFA-VEGFR2 Pathway", "Interleukin-2 signaling"], "50658": ["Oxidative Stress Induced Senescence", "FCERI mediated MAPK activation", "JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1", "Activation of the AP-1 family of transcription factors"], "50662": ["Organic cation transport", "RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "RUNX1 regulates estrogen receptor mediated transcription", "Regulation of RUNX1 Expression and Activity", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "RUNX1 regulates transcription of genes involved in BCR signaling", "RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "RUNX1 regulates transcription of genes involved in interleukin signaling", "Estrogen-dependent gene expression"], "50663": ["CaMK IV-mediated phosphorylation of CREB", "Calmodulin induced events", "Cam-PDE 1 activation", "Platelet degranulation ", "Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "PKA activation", "Synthesis of IP3 and IP4 in the cytosol", "Calcineurin activates NFAT", "eNOS activation", "Inactivation, recovery and regulation of the phototransduction cascade", "Stimuli-sensing channels", "FCERI mediated Ca+2 mobilization", "Ca2+ pathway", "Reduction of cytosolic Ca++ levels", "Sodium/Calcium exchangers", "Unblocking of NMDA receptors, glutamate binding and activation", "CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "Smooth Muscle Contraction", "Activation of Ca-permeable Kainate Receptor", "VEGFR2 mediated vascular permeability", "Phase 0 - rapid depolarisation", "Ion homeostasis", "CLEC7A (Dectin-1) induces NFAT activation", "RHO GTPases activate IQGAPs", "RHO GTPases activate PAKs", "RAF activation", "RAF/MAP kinase cascade", "Glycogen breakdown (glycogenolysis)", "Protein methylation", "Ion transport by P-type ATPases", "Activation of RAC1 downstream of NMDARs", "Long-term potentiation"], "50664": ["PLC beta mediated events", "G-protein activation", "Ca2+ pathway", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "50671": ["ChREBP activates metabolic gene expression", "Vitamin B5 (pantothenate) metabolism", "Fatty acyl-CoA biosynthesis"], "50672": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "50676": ["Amino acid transport across the plasma membrane", "Na+/Cl- dependent neurotransmitter transporters", "Creatine metabolism", "Reuptake of GABA"], "50678": ["cGMP effects", "G alpha (s) signalling events"], "50682": ["Digestion of dietary lipid"], "50685": ["Smooth Muscle Contraction", "RHO GTPases activate PAKs"], "50687": ["Basigin interactions", "L1CAM interactions", "Recycling pathway of L1", "Interaction between L1 and Ankyrins", "Signal transduction by L1"], "50688": ["Presynaptic depolarization and calcium channel opening", "Phase 0 - rapid depolarisation", "Phase 2 - plateau phase"], "50689": ["MAPK3 (ERK1) activation", "RAF-independent MAPK1/3 activation", "ISG15 antiviral mechanism", "Spry regulation of FGF signaling", "Golgi Cisternae Pericentriolar Stack Reorganization", "Frs2-mediated activation", "ERK/MAPK targets", "ERKs are inactivated", "Regulation of actin dynamics for phagocytic cup formation", "Senescence-Associated Secretory Phenotype (SASP)", "NCAM signaling for neurite out-growth", "Signal transduction by L1", "Activation of the AP-1 family of transcription factors", "Thrombin signalling through proteinase activated receptors (PARs)", "Negative regulation of FGFR1 signaling", "RHO GTPases Activate WASPs and WAVEs", "RAF/MAP kinase cascade", "MAP2K and MAPK activation", "Negative feedback regulation of MAPK pathway", "Negative regulation of MAPK pathway", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "RNA Polymerase I Promoter Opening", "Signal attenuation", "Gastrin-CREB signalling pathway via PKC and MAPK", "Growth hormone receptor signaling"], "50690": ["Creatine metabolism"], "50693": ["Platelet degranulation "], "50719": ["Basigin interactions", "Amino acid transport across the plasma membrane", "Tryptophan catabolism"], "50866": ["Neutrophil degranulation", "RAB geranylgeranylation", "MET receptor recycling"], "50938": ["CDO in myogenesis", "Ligand-receptor interactions", "Activation of SMO"], "50993": ["Neutrophil degranulation", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "53372": ["Transport of Mature mRNA derived from an Intron-Containing Transcript", "SUMOylation of DNA damage response and repair proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of DNA replication proteins"], "53949": ["Muscarinic acetylcholine receptors", "G alpha (q) signalling events"], "541462": ["Post-translational modification: synthesis of GPI-anchored proteins"], "54223": ["PKA activation", "Adenylate cyclase activating pathway", "Adenylate cyclase inhibitory pathway", "G alpha (z) signalling events", "Hedgehog 'off' state"], "54225": ["Cell surface interactions at the vascular wall", "Scavenging by Class B Receptors", "Scavenging by Class A Receptors", "Scavenging by Class H Receptors", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Platelet sensitization by LDL", "Regulation of TLR by endogenous ligand", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "VLDL assembly", "Post-translational protein phosphorylation", "Chylomicron assembly", "Chylomicron remodeling", "Chylomicron clearance", "LDL clearance", "VLDL clearance", "Retinoid metabolism and transport"], "54226": ["Platelet degranulation ", "ECM proteoglycans", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "G alpha (q) signalling events", "G alpha (i) signalling events", "Lysosome Vesicle Biogenesis", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "Advanced glycosylation endproduct receptor signaling", "Post-translational protein phosphorylation", "TRAF6 mediated NF-kB activation"], "54227": ["Regulation of actin dynamics for phagocytic cup formation", "EPHB-mediated forward signaling", "RHO GTPases Activate WASPs and WAVEs"], "54231": ["Erythrocytes take up carbon dioxide and release oxygen", "Reversible hydration of carbon dioxide"], "54232": ["Reversible hydration of carbon dioxide"], "54233": ["Reversible hydration of carbon dioxide"], "54237": ["MAPK3 (ERK1) activation", "APC/C:Cdc20 mediated degradation of Cyclin B", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Phosphorylation of Emi1", "Resolution of Sister Chromatid Cohesion", "Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "MAPK6/MAPK4 signaling", "Ovarian tumor domain proteases", "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "Regulation of TP53 Degradation", "Cyclin A/B1/B2 associated events during G2/M transition", "G2/M DNA replication checkpoint", "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "The role of GTSE1 in G2/M progression after G2 checkpoint", "AURKA Activation by TPX2"], "54238": ["Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "Oncogene Induced Senescence", "Cyclin D associated events in G1"], "54239": ["Highly sodium permeable acetylcholine nicotinic receptors", "Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "Highly calcium permeable nicotinic acetylcholine receptors"], "54240": ["Highly sodium permeable acetylcholine nicotinic receptors"], "54244": ["Regulation of gene expression by Hypoxia-inducible Factor", "Formation of the beta-catenin:TCF transactivating complex", "NOTCH1 Intracellular Domain Regulates Transcription", "LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "Attenuation phase", "Notch-HLH transcription pathway", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)", "CD209 (DC-SIGN) signaling", "Activation of the TFAP2 (AP-2) family of transcription factors", "RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "RUNX3 regulates NOTCH signaling", "Estrogen-dependent gene expression", "TRAF3-dependent IRF activation pathway", "TRAF6 mediated IRF7 activation", "Regulation of FOXO transcriptional activity by acetylation"], "54245": ["ARMS-mediated activation", "Downstream signal transduction", "Regulation of actin dynamics for phagocytic cup formation", "p130Cas linkage to MAPK signaling for integrins", "VEGFA-VEGFR2 Pathway", "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "MET activates RAP1 and RAC1", "MET receptor recycling", "Regulation of signaling by CBL"], "54246": ["Fatty acids", "Xenobiotics", "CYP2E1 reactions"], "54250": ["PI3K Cascade", "PIP3 activates AKT signaling", "FGFR4 ligand binding and activation", "FGFR1b ligand binding and activation", "FGFR3c ligand binding and activation", "FGFR1c ligand binding and activation", "FGFR2c ligand binding and activation", "FGFR2b ligand binding and activation", "Syndecan interactions", "Non-integrin membrane-ECM interactions", "Phospholipase C-mediated cascade: FGFR1", "Phospholipase C-mediated cascade; FGFR2", "Phospholipase C-mediated cascade; FGFR3", "Phospholipase C-mediated cascade; FGFR4", "Downstream signaling of activated FGFR1", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "PI-3K cascade:FGFR3", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "PI-3K cascade:FGFR4", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "FGFRL1 modulation of FGFR1 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "54251": ["Neurophilin interactions with VEGF and VEGFR", "VEGF binds to VEGFR leading to receptor dimerization"], "54254": ["Factors involved in megakaryocyte development and platelet production"], "54257": ["Activation of Na-permeable kainate receptors", "Activation of Ca-permeable Kainate Receptor"], "54260": ["Synthesis of IP3 and IP4 in the cytosol"], "54261": ["Ca2+ activated K+ channels"], "54262": ["Ca2+ activated K+ channels"], "54266": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Integrin cell surface interactions"], "54268": ["MAPK6/MAPK4 signaling"], "54271": ["Activation of Matrix Metalloproteinases"], "54278": ["Nuclear Receptor transcription pathway"], "54279": ["Post-translational modification: synthesis of GPI-anchored proteins"], "54281": ["Elastic fibre formation", "Removal of aminoterminal propeptides from gamma-carboxylated proteins", "NGF processing", "Assembly of active LPL and LIPC lipase complexes"], "54283": ["Glycolysis"], "54287": ["ISG15 antiviral mechanism"], "54289": ["G alpha (q) signalling events", "G alpha (i) signalling events"], "54292": ["G alpha (i) signalling events"], "54293": ["G alpha (q) signalling events", "G alpha (i) signalling events"], "54297": ["G alpha (i) signalling events"], "54299": ["Downregulation of SMAD2/3:SMAD4 transcriptional activity", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)"], "54300": ["Cation-coupled Chloride cotransporters"], "54301": ["Transport of bile salts and organic acids, metal ions and amine compounds"], "54302": ["Transport of bile salts and organic acids, metal ions and amine compounds"], "54303": ["Antimicrobial peptides"], "54305": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "54314": ["Thyroxine biosynthesis"], "54315": ["The fatty acid cycling model", "The proton buffering model"], "54318": ["L13a-mediated translational silencing of Ceruloplasmin expression", "PERK regulates gene expression", "ABC-family proteins mediated transport", "Translation initiation complex formation", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Recycling of eIF2:GDP"], "54319": ["Netrin-1 signaling", "Recycling pathway of L1"], "54350": ["COPII-mediated vesicle transport"], "54398": ["Fatty acyl-CoA biosynthesis"], "54400": ["COPI-mediated anterograde transport", "Intra-Golgi traffic"], "54404": ["Platelet degranulation "], "54705": ["Regulation of pyruvate dehydrogenase (PDH) complex"], "553106": ["Activation of Ca-permeable Kainate Receptor"], "554302": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "55939": ["Retinoid metabolism and transport"], "56010": ["Activation of BAD and translocation to mitochondria ", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "RHO GTPases activate PKNs", "TP53 Regulates Metabolic Genes", "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "AURKA Activation by TPX2", "Regulation of localization of FOXO transcription factors"], "56011": ["Activation of BAD and translocation to mitochondria ", "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "mTOR signalling", "mTORC1-mediated signalling", "Signaling by Hippo", "Rap1 signalling", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "RHO GTPases activate PKNs", "TP53 Regulates Metabolic Genes", "RAF activation", "MAP2K and MAPK activation", "Negative regulation of MAPK pathway", "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "Regulation of localization of FOXO transcription factors"], "56042": ["COPII-mediated vesicle transport", "COPI-mediated anterograde transport"], "56082": ["Golgi Cisternae Pericentriolar Stack Reorganization", "COPII-mediated vesicle transport", "COPI-mediated anterograde transport"], "56281": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "56611": ["Neutrophil degranulation", "Dissolution of Fibrin Clot"], "56646": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "56718": ["PIP3 activates AKT signaling", "Macroautophagy", "mTOR signalling", "mTORC1-mediated signalling", "HSF1-dependent transactivation", "Energy dependent regulation of mTOR by LKB1-AMPK", "CD28 dependent PI3K/Akt signaling", "VEGFR2 mediated vascular permeability", "TP53 Regulates Metabolic Genes", "Regulation of PTEN gene transcription"], "56769": ["Complex I biogenesis"], "56780": ["Neutrophil degranulation"], "56781": ["Striated Muscle Contraction"], "56782": ["Platelet degranulation "], "56783": ["Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "56813": ["Class B/2 (Secretin family receptors)", "G alpha (s) signalling events"], "56817": ["Phase 1 - inactivation of fast Na+ channels"], "56820": ["G alpha (s) signalling events", "Calcitonin-like ligand receptors"], "56822": ["PIP3 activates AKT signaling", "CD28 co-stimulation", "CD28 dependent PI3K/Akt signaling", "CD28 dependent Vav1 pathway", "CTLA4 inhibitory signaling", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "57025": ["Degradation of the extracellular matrix", "Invadopodia formation"], "57301": ["G alpha (i) signalling events"], "57302": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (i) signalling events"], "57305": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "574531": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Neutrophil degranulation"], "58812": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "58813": ["Purine catabolism"], "58814": ["Striated Muscle Contraction"], "58817": ["COPII-mediated vesicle transport", "MHC class II antigen presentation", "Cargo concentration in the ER", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "58822": ["WNT mediated activation of DVL", "Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "Major pathway of rRNA processing in the nucleolus and cytosol", "AURKA Activation by TPX2"], "58826": ["Neutrophil degranulation"], "58834": ["Rho GTPase cycle"], "58835": ["Serine biosynthesis"], "58840": ["MAPK6/MAPK4 signaling"], "58851": ["Nuclear Receptor transcription pathway", "SUMOylation of intracellular receptors", "VLDLR internalisation and degradation"], "58852": ["Nuclear Receptor transcription pathway", "SUMOylation of intracellular receptors", "VLDLR internalisation and degradation"], "58853": ["Nuclear Receptor transcription pathway"], "58857": ["Sphingolipid de novo biosynthesis", "Neutrophil degranulation"], "58868": ["PCP/CE pathway", "Asymmetric localization of PCP proteins", "Disassembly of the destruction complex and recruitment of AXIN to the membrane"], "58917": ["Scavenging of heme from plasma"], "58918": ["NOD1/2 Signaling Pathway", "AKT phosphorylates targets in the cytosol", "Caspase activation via Dependence Receptors in the absence of ligand", "Regulation of the apoptosome activity"], "58919": ["SCF(Skp2)-mediated degradation of p27/p21", "RMTs methylate histone arginines", "Ubiquitin-dependent degradation of Cyclin D1", "Cyclin D associated events in G1", "PTK6 Regulates Cell Cycle", "Transcriptional regulation by RUNX2", "Regulation of RUNX1 Expression and Activity", "RUNX3 regulates p14-ARF"], "58921": ["Polo-like kinase mediated events", "Cyclin A/B1/B2 associated events during G2/M transition"], "58923": ["The NLRP3 inflammasome"], "58936": ["TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "58942": ["Presynaptic depolarization and calcium channel opening", "Phase 0 - rapid depolarisation", "Phase 2 - plateau phase"], "58947": ["MET Receptor Activation"], "58948": ["Unblocking of NMDA receptors, glutamate binding and activation", "Activation of Ca-permeable Kainate Receptor", "RAF/MAP kinase cascade", "Neurexins and neuroligins", "Synaptic adhesion-like molecules"], "58949": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (q) signalling events", "Neutrophil degranulation"], "58950": ["Stimuli-sensing channels", "Ion homeostasis"], "58953": ["Cytosolic sulfonation of small molecules"], "58958": ["Transport of Mature mRNA derived from an Intron-Containing Transcript", "SUMOylation of DNA damage response and repair proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of DNA replication proteins"], "58959": ["Class B/2 (Secretin family receptors)", "G alpha (s) signalling events"], "58960": ["MAPK1 (ERK2) activation", "Signal transduction by L1", "RAF activation", "MAP2K and MAPK activation", "Negative feedback regulation of MAPK pathway"], "58961": ["Regulation of ornithine decarboxylase (ODC)"], "58962": ["Glutathione conjugation", "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"], "58965": ["G alpha (s) signalling events", "Calcitonin-like ligand receptors"], "58966": ["G alpha (s) signalling events", "Calcitonin-like ligand receptors"], "58970": ["Sphingolipid de novo biosynthesis", "Neutrophil degranulation"], "58971": ["Ion homeostasis", "Ion transport by P-type ATPases"], "58974": ["Macroautophagy", "TBC/RABGAPs"], "58976": ["Zinc efflux and compartmentalization by the SLC30 family"], "58978": ["Recycling of bile acids and salts", "Transport of organic anions"], "58979": ["Activation of G protein gated Potassium channels", "G-protein activation", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42", "Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "58980": ["Sodium-coupled sulphate, di- and tri-carboxylate transporters"], "58981": ["Voltage gated Potassium channels"], "58982": ["A tetrasaccharide linker sequence is required for GAG synthesis", "Chondroitin sulfate biosynthesis", "Dermatan sulfate biosynthesis", "CS/DS degradation", "ECM proteoglycans"], "58983": ["TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "RAB geranylgeranylation"], "59075": ["G alpha (s) signalling events"], "59076": ["G alpha (s) signalling events"], "59077": ["Inactivation, recovery and regulation of the phototransduction cascade"], "59086": ["Platelet degranulation ", "Cell surface interactions at the vascular wall", "Molecules associated with elastic fibres", "Downregulation of TGF-beta receptor signaling", "TGF-beta receptor signaling activates SMADs", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "Syndecan interactions", "RUNX3 regulates CDKN1A transcription", "Regulation of RUNX3 expression and activity", "RUNX3 regulates p14-ARF"], "59102": ["Translesion synthesis by REV1", "Recognition of DNA damage by PCNA-containing replication complex", "Translesion Synthesis by POLH", "Removal of the Flap Intermediate from the C-strand", "Activation of ATR in response to replication stress", "Regulation of HSF1-mediated heat shock response", "Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "PCNA-Dependent Long Patch Base Excision Repair", "Translesion synthesis by POLK", "Translesion synthesis by POLI", "Termination of translesion DNA synthesis", "HDR through Single Strand Annealing (SSA)", "HDR through Homologous Recombination (HRR)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Formation of Incision Complex in GG-NER", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Fanconi Anemia Pathway", "Activation of the pre-replicative complex", "Removal of the Flap Intermediate"], "59103": ["Synthesis of Prostaglandins (PG) and Thromboxanes (TX)"], "59106": ["Molecules associated with elastic fibres"], "59108": ["Intracellular oxygen transport"], "59109": ["Frs2-mediated activation", "ARMS-mediated activation", "Retrograde neurotrophin signalling", "TRKA activation by NGF", "PI3K/AKT activation"], "59113": ["Tryptophan catabolism"], "59264": ["Leukotriene receptors", "G alpha (q) signalling events"], "59268": ["Synthesis of IPs in the nucleus"], "59293": ["G alpha (q) signalling events", "G alpha (i) signalling events"], "59294": ["Recognition of DNA damage by PCNA-containing replication complex", "Polymerase switching on the C-strand of the telomere", "Processive synthesis on the C-strand of the telomere", "Telomere C-strand (Lagging Strand) Synthesis", "Removal of the Flap Intermediate from the C-strand", "PCNA-Dependent Long Patch Base Excision Repair", "Termination of translesion DNA synthesis", "HDR through Homologous Recombination (HRR)", "Gap-filling DNA repair synthesis and ligation in GG-NER", "Dual Incision in GG-NER", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Polymerase switching", "Removal of the Flap Intermediate", "Processive synthesis on the lagging strand"], "59299": ["Stimuli-sensing channels", "Ion homeostasis"], "59301": ["G alpha (q) signalling events", "Synthesis, secretion, and deacylation of Ghrelin"], "59317": ["Trafficking of AMPA receptors", "Neurexins and neuroligins"], "59319": ["Macroautophagy"], "59320": ["Hedgehog 'off' state"], "59322": ["MAP2K and MAPK activation"], "59324": ["Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)", "Phase 4 - resting membrane potential"], "59325": ["Signaling by ERBB2", "Signaling by ERBB4", "SHC1 events in ERBB2 signaling", "PI3K events in ERBB4 signaling", "SHC1 events in ERBB4 signaling", "PIP3 activates AKT signaling", "Signaling by EGFR", "GRB2 events in EGFR signaling", "GAB1 signalosome", "SHC1 events in EGFR signaling", "EGFR downregulation", "GRB2 events in ERBB2 signaling", "PI3K events in ERBB2 signaling", "EGFR interacts with phospholipase C-gamma", "RAF/MAP kinase cascade", "ERBB2 Regulates Cell Motility", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "ERBB2 Activates PTK6 Signaling", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "Downregulation of ERBB2 signaling"], "59326": ["Integrin alphaIIb beta3 signaling", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Rap1 signalling", "Regulation of insulin secretion"], "59328": ["Signaling by BMP"], "60325": ["Dissolution of Fibrin Clot"], "60326": ["Voltage gated Potassium channels"], "60327": ["Platelet degranulation ", "Common Pathway of Fibrin Clot Formation"], "60331": ["Josephin domain DUBs", "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes"], "60333": ["Post-translational modification: synthesis of GPI-anchored proteins", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "60334": ["MASTL Facilitates Mitotic Progression"], "60335": ["Formation of the cornified envelope"], "60336": ["MASTL Facilitates Mitotic Progression"], "60337": ["Orexin and neuropeptides FF and QRFP bind to their respective receptors", "G alpha (q) signalling events"], "60341": ["CaMK IV-mediated phosphorylation of CREB", "CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "Activation of RAC1 downstream of NMDARs"], "60347": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "60349": ["Nuclear Receptor transcription pathway", "SUMOylation of intracellular receptors", "Estrogen-dependent gene expression"], "60350": ["Toll Like Receptor 4 (TLR4) Cascade", "Transfer of LPS from LBP carrier to CD14", "Regulation of TLR by endogenous ligand", "Neutrophil degranulation", "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon", "TRAF6-mediated induction of TAK1 complex within TLR4 complex"], "60351": ["Recycling of bile acids and salts", "Synthesis of bile acids and bile salts", "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "Endogenous sterols", "Nuclear Receptor transcription pathway", "SUMOylation of intracellular receptors"], "60352": ["NOD1/2 Signaling Pathway", "CDO in myogenesis", "DSCAM interactions", "VEGFA-VEGFR2 Pathway"], "60371": ["Apoptotic cleavage of cellular proteins", "NOD1/2 Signaling Pathway", "RIPK1-mediated regulated necrosis", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "TNFR2 non-canonical NF-kB pathway", "Regulation of necroptotic cell death", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "Ub-specific processing proteases"], "60373": ["SUMOylation of RNA binding proteins", "Major pathway of rRNA processing in the nucleolus and cytosol"], "60374": ["Breakdown of the nuclear lamina", "Depolymerisation of the Nuclear Lamina"], "60376": ["mRNA Splicing - Major Pathway"], "60377": ["Dopamine Neurotransmitter Release Cycle", "RHO GTPases Activate Rhotekin and Rhophilins"], "60378": ["Post-translational modification: synthesis of GPI-anchored proteins"], "60379": ["Collagen degradation", "Extracellular matrix organization", "Collagen biosynthesis and modifying enzymes", "Signaling by PDGF", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "NCAM1 interactions", "MET activates PTK2 signaling", "Collagen chain trimerization"], "60381": ["Small interfering RNA (siRNA) biogenesis"], "60383": ["Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "Antigen processing: Ubiquitination & Proteasome degradation"], "60395": ["Effects of PIP2 hydrolysis", "Elevation of cytosolic Ca2+ levels", "TRP channels"], "60399": ["G alpha (i) signalling events", "Lysosphingolipid and LPA receptors"], "60421": ["RMTs methylate histone arginines", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "60427": ["PIP3 activates AKT signaling", "Signaling by SCF-KIT", "Regulation of KIT signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "60431": ["Sphingolipid de novo biosynthesis"], "60432": ["G alpha (s) signalling events", "Glucagon-type ligand receptors"], "60442": ["Dopamine Neurotransmitter Release Cycle"], "60443": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "60445": ["Macroautophagy", "Inhibition of TSC complex formation by PKB", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "TBC/RABGAPs"], "60448": ["Serotonin receptors", "G alpha (i) signalling events"], "60449": ["Activation of G protein gated Potassium channels", "G-protein activation", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42", "Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "60450": ["Downregulation of ERBB2 signaling"], "60451": ["Olfactory Signaling Pathway"], "60460": ["Regulation of HSF1-mediated heat shock response", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Attenuation phase"], "60464": ["PI3K Cascade", "PIP3 activates AKT signaling", "FGFR4 ligand binding and activation", "FGFR3c ligand binding and activation", "FGFR2c ligand binding and activation", "Phospholipase C-mediated cascade; FGFR2", "Phospholipase C-mediated cascade; FGFR3", "Phospholipase C-mediated cascade; FGFR4", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "PI-3K cascade:FGFR3", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "PI-3K cascade:FGFR4", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "60465": ["Clathrin-mediated endocytosis"], "60562": ["Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network"], "60564": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "60568": ["Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "60571": ["B-WICH complex positively regulates rRNA expression"], "60575": ["Surfactant metabolism"], "60577": ["Proton/oligopeptide cotransporters"], "60582": ["Interleukin-1 signaling"], "60584": ["IL-6-type cytokine receptor ligand interactions"], "60586": ["Stimuli-sensing channels"], "60590": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "60627": ["Insulin processing", "VxPx cargo-targeting to cilium"], "60628": ["Signaling by ROBO receptors", "Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "60661": ["Transcriptional Regulation by E2F6"], "60662": ["PI3K Cascade", "PIP3 activates AKT signaling", "FGFR3c ligand binding and activation", "FGFR1c ligand binding and activation", "FGFR2c ligand binding and activation", "Phospholipase C-mediated cascade: FGFR1", "Phospholipase C-mediated cascade; FGFR2", "Phospholipase C-mediated cascade; FGFR3", "Downstream signaling of activated FGFR1", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "PI-3K cascade:FGFR3", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "FGFRL1 modulation of FGFR1 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "60664": ["GPVI-mediated activation cascade", "PIP3 activates AKT signaling", "Interleukin-7 signaling", "Signaling by SCF-KIT", "Synthesis of PIPs at the plasma membrane", "Costimulation by the CD28 family", "CD28 dependent PI3K/Akt signaling", "G alpha (q) signalling events", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "RET signaling", "Interleukin receptor SHC signaling", "Regulation of signaling by CBL"], "60665": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "60666": ["Synthesis of PA"], "60669": ["Class A/1 (Rhodopsin-like receptors)"], "613225": ["Defensins", "Alpha-defensins", "Neutrophil degranulation"], "613267": ["Phosphate bond hydrolysis by NTPDase proteins"], "619549": ["Cholesterol biosynthesis"], "619561": ["Mitochondrial Fatty Acid Beta-Oxidation"], "619577": ["Antigen processing: Ubiquitination & Proteasome degradation"], "619579": ["Nuclear Receptor transcription pathway"], "619580": ["Interconversion of nucleotide di- and triphosphates"], "63835": ["CTLA4 inhibitory signaling"], "63836": ["Platelet degranulation "], "63843": ["P2Y receptors", "G alpha (i) signalling events"], "63847": ["Ion homeostasis", "Ion transport by P-type ATPases"], "63848": ["Ion homeostasis", "Ion transport by P-type ATPases"], "63850": ["Peptide ligand-binding receptors"], "63851": ["Phase 0 - rapid depolarisation"], "63864": ["Branched-chain amino acid catabolism"], "63866": ["Stimuli-sensing channels"], "63878": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "63879": ["SMAC (DIABLO) binds to IAPs ", "SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ", "SMAC, XIAP-regulated apoptotic response", "Deactivation of the beta-catenin transactivating complex", "RIPK1-mediated regulated necrosis", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "Regulation of necroptotic cell death", "Regulation of PTEN localization", "Regulation of PTEN stability and activity"], "63880": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Neutrophil degranulation", "Post-translational protein phosphorylation"], "63882": ["Stimuli-sensing channels"], "63883": ["Phase 3 - rapid repolarisation", "Phase 2 - plateau phase"], "63885": ["cGMP effects", "G alpha (s) signalling events"], "63887": ["Peptide ligand-binding receptors", "G alpha (q) signalling events", "G alpha (i) signalling events"], "63938": ["Branched-chain amino acid catabolism"], "63994": ["Rho GTPase cycle"], "63995": ["RAF-independent MAPK1/3 activation", "Negative regulation of MAPK pathway"], "63997": ["Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"], "64001": ["Vitamin C (ascorbate) metabolism"], "64013": ["Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "64018": ["Transport of vitamins, nucleosides, and related molecules"], "64022": ["Signaling by ERBB2", "Signaling by ERBB4", "SHC1 events in ERBB2 signaling", "PI3K events in ERBB4 signaling", "SHC1 events in ERBB4 signaling", "PIP3 activates AKT signaling", "Signaling by EGFR", "GRB2 events in EGFR signaling", "GAB1 signalosome", "SHC1 events in EGFR signaling", "EGFR downregulation", "GRB2 events in ERBB2 signaling", "PI3K events in ERBB2 signaling", "EGFR interacts with phospholipase C-gamma", "RAF/MAP kinase cascade", "ERBB2 Regulates Cell Motility", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "ERBB2 Activates PTK6 Signaling", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "Downregulation of ERBB2 signaling"], "64025": ["Cell surface interactions at the vascular wall"], "64026": ["SMAC (DIABLO) binds to IAPs ", "SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ", "Apoptotic cleavage of cellular proteins", "SMAC, XIAP-regulated apoptotic response", "Caspase-mediated cleavage of cytoskeletal proteins"], "64028": ["Small interfering RNA (siRNA) biogenesis"], "64030": ["PIP3 activates AKT signaling", "Signaling by SCF-KIT", "Regulation of KIT signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "64035": ["Neutrophil degranulation", "Glycogen breakdown (glycogenolysis)"], "64036": ["Class B/2 (Secretin family receptors)", "Neutrophil degranulation", "COPI-mediated anterograde transport", "Regulation of Complement cascade"], "64040": ["Carnitine synthesis"], "64042": ["Peptide ligand-binding receptors", "G alpha (q) signalling events", "G alpha (i) signalling events"], "64043": ["O-linked glycosylation of mucins"], "64044": ["Apoptotic cleavage of cellular proteins", "NOD1/2 Signaling Pathway", "Regulation by c-FLIP", "RIPK1-mediated regulated necrosis", "CASP8 activity is inhibited", "CLEC7A/inflammasome pathway", "Dimerization of procaspase-8", "Activation, myristolyation of BID and translocation to mitochondria", "Apoptotic execution phase", "FasL/ CD95L signaling", "TRAIL  signaling"], "64045": ["Interconversion of nucleotide di- and triphosphates"], "64046": ["Cytosolic sensors of pathogen-associated DNA ", "DNA Damage/Telomere Stress Induced Senescence", "HDR through Single Strand Annealing (SSA)", "HDR through MMEJ (alt-NHEJ)", "HDR through Homologous Recombination (HRR)", "Sensing of DNA Double Strand Breaks", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Nonhomologous End-Joining (NHEJ)", "Homologous DNA Pairing and Strand Exchange", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "G2/M DNA damage checkpoint"], "64047": ["Retinoid metabolism and transport"], "64055": ["Digestion"], "64076": ["Transport and synthesis of PAPS", "Multifunctional anion exchangers"], "64119": ["Phase 4 - resting membrane potential"], "64120": ["Tandem pore domain halothane-inhibited K+ channel (THIK)", "Phase 4 - resting membrane potential"], "64134": ["A tetrasaccharide linker sequence is required for GAG synthesis"], "641434": ["Formation of ATP by chemiosmotic coupling", "Cristae formation"], "641519": ["Beta defensins", "Defensins"], "64152": ["Hyaluronan uptake and degradation"], "64154": ["COPII-mediated vesicle transport", "Cargo concentration in the ER", "COPI-mediated anterograde transport", "Intra-Golgi traffic"], "64157": ["eNOS activation"], "64158": ["Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Regulation of PLK1 Activity at G2/M Transition", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Recycling pathway of L1", "Hedgehog 'off' state", "Cilium Assembly", "Anchoring of the basal body to the plasma membrane", "Intraflagellar transport", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "AURKA Activation by TPX2", "Carboxyterminal post-translational modifications of tubulin", "Kinesins"], "64159": ["Caspase-mediated cleavage of cytoskeletal proteins", "NCAM signaling for neurite out-growth", "Interaction between L1 and Ankyrins", "RAF/MAP kinase cascade", "Neutrophil degranulation", "COPI-mediated anterograde transport"], "641621": ["Beta defensins", "Defensins"], "641626": ["Beta defensins", "Defensins"], "641627": ["Beta defensins", "Defensins"], "641629": ["Beta defensins", "Defensins"], "641636": ["Beta defensins", "Defensins"], "641640": ["Beta defensins", "Defensins"], "641641": ["Beta defensins", "Defensins"], "641643": ["Beta defensins", "Defensins"], "641644": ["Beta defensins", "Defensins"], "641645": ["Beta defensins", "Defensins"], "641650": ["Beta defensins", "Defensins"], "641651": ["Beta defensins", "Defensins"], "641652": ["Beta defensins", "Defensins"], "641653": ["Beta defensins", "Defensins"], "641655": ["Beta defensins", "Defensins"], "641656": ["Beta defensins", "Defensins"], "641658": ["Beta defensins", "Defensins"], "64171": ["CLEC7A (Dectin-1) signaling"], "64185": ["Neutrophil degranulation"], "64187": ["Retrograde transport at the Trans-Golgi-Network"], "64188": ["Factors involved in megakaryocyte development and platelet production"], "64189": ["Neutrophil degranulation", "COPI-independent Golgi-to-ER retrograde traffic"], "64190": ["Ion homeostasis", "Ion transport by P-type ATPases"], "64191": ["Cholesterol biosynthesis via desmosterol"], "64192": ["Phenylalanine and tyrosine catabolism"], "64193": ["APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Separation of Sister Chromatids"], "64196": ["SUMOylation of transcription cofactors"], "64198": ["Processing of SMDT1"], "64199": ["G-protein activation", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42"], "64200": ["FGFR2 alternative splicing", "mRNA Splicing - Major Pathway"], "64202": ["ER-Phagosome pathway", "Scavenging by Class A Receptors", "Calnexin/calreticulin cycle", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "64204": ["Assembly of collagen fibrils and other multimeric structures", "Caspase-mediated cleavage of cytoskeletal proteins", "Type I hemidesmosome assembly"], "64205": ["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "64206": ["Tryptophan catabolism"], "64226": ["PIP3 activates AKT signaling", "Macroautophagy", "mTOR signalling", "mTORC1-mediated signalling", "HSF1-dependent transactivation", "Energy dependent regulation of mTOR by LKB1-AMPK", "CD28 dependent PI3K/Akt signaling", "VEGFR2 mediated vascular permeability", "TP53 Regulates Metabolic Genes", "Regulation of PTEN gene transcription"], "64303": ["Signaling by ROBO receptors", "PCP/CE pathway", "RHO GTPases Activate Formins"], "64304": ["Beta oxidation of butanoyl-CoA to acetyl-CoA"], "64305": ["Cytosolic sulfonation of small molecules"], "64310": ["Synthesis of PIPs at the plasma membrane", "Synthesis of PIPs at the Golgi membrane", "MHC class II antigen presentation", "Clathrin derived vesicle budding", "Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "Intra-Golgi traffic"], "64313": ["Amino acid synthesis and interconversion (transamination)"], "64314": ["NOD1/2 Signaling Pathway", "NADE modulates death signalling", "TP53 Regulates Transcription of Caspase Activators and Caspases"], "64315": ["Assembly of collagen fibrils and other multimeric structures", "Type I hemidesmosome assembly"], "64351": ["COPII-mediated vesicle transport", "COPI-mediated anterograde transport", "Intra-Golgi traffic"], "64352": ["Glutathione conjugation"], "64356": ["Long-term potentiation"], "64357": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "64358": ["Voltage gated Potassium channels"], "64360": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "64363": ["RAF activation", "MAP2K and MAPK activation", "Negative regulation of MAPK pathway"], "64365": ["Cobalamin (Cbl, vitamin B12) transport and metabolism"], "64366": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "64367": ["Collagen biosynthesis and modifying enzymes"], "64369": ["Sphingolipid de novo biosynthesis"], "64373": ["GPVI-mediated activation cascade", "Rho GTPase cycle", "G alpha (12/13) signalling events", "Sema4D induced cell migration and growth-cone collapse", "RHO GTPases activate PKNs", "RHO GTPases activate CIT", "RHO GTPases Activate ROCKs", "RHO GTPases Activate Formins"], "64442": ["Keratan sulfate biosynthesis", "Sialic acid metabolism", "Termination of O-glycan biosynthesis"], "64445": ["Keratan sulfate biosynthesis", "Sialic acid metabolism", "Termination of O-glycan biosynthesis"], "64459": ["Lectin pathway of complement activation", "Initial triggering of complement"], "64460": ["E3 ubiquitin ligases ubiquitinate target proteins", "Peroxisomal protein import"], "64462": ["COPII-mediated vesicle transport", "Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "Major pathway of rRNA processing in the nucleolus and cytosol", "AURKA Activation by TPX2"], "64465": ["GPVI-mediated activation cascade", "EGFR downregulation", "Rho GTPase cycle", "Regulation of actin dynamics for phagocytic cup formation", "CDO in myogenesis", "CD28 dependent Vav1 pathway", "EPHB-mediated forward signaling", "DCC mediated attractive signaling", "VEGFA-VEGFR2 Pathway", "RHO GTPases activate KTN1", "RHO GTPases activate IQGAPs", "RHO GTPases activate PAKs", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate Formins", "MAPK6/MAPK4 signaling", "G beta:gamma signalling through CDC42", "Factors involved in megakaryocyte development and platelet production"], "64466": ["Activation of the TFAP2 (AP-2) family of transcription factors", "Estrogen-dependent gene expression"], "64467": ["Phosphate bond hydrolysis by NTPDase proteins"], "64468": ["Hyaluronan uptake and degradation"], "64470": ["Recognition of DNA damage by PCNA-containing replication complex", "DNA Damage Recognition in GG-NER", "Formation of Incision Complex in GG-NER", "Dual Incision in GG-NER", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Neddylation"], "64473": ["Cytosolic sulfonation of small molecules"], "64474": ["HDL clearance"], "64475": ["Collagen biosynthesis and modifying enzymes"], "64476": ["Pink/Parkin Mediated Mitophagy", "Factors involved in megakaryocyte development and platelet production"], "64508": ["PKA activation", "Adenylate cyclase activating pathway", "Adenylate cyclase inhibitory pathway", "G alpha (z) signalling events", "Hedgehog 'off' state"], "64511": ["Inactivation, recovery and regulation of the phototransduction cascade"], "64514": ["Recycling of eIF2:GDP"], "64515": ["Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components", "Inactivation of APC/C via direct inhibition of the APC/C complex", "Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "APC/C:Cdc20 mediated degradation of Cyclin B", "SCF-beta-TrCP mediated degradation of Emi1", "APC/C:Cdc20 mediated degradation of Securin", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "Regulation of APC/C activators between G1/S and early anaphase", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Phosphorylation of Emi1", "APC-Cdc20 mediated degradation of Nek2A", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Ub-specific processing proteases", "Mitotic Prometaphase", "Antigen processing: Ubiquitination & Proteasome degradation"], "64516": ["Intra-Golgi traffic"], "64517": ["Antigen processing: Ubiquitination & Proteasome degradation"], "64519": ["Phosphate bond hydrolysis by NTPDase proteins"], "64520": ["SUMOylation of transcription factors", "RNA Polymerase I Transcription Initiation", "Regulation of PTEN gene transcription"], "64522": ["Cellular hexose transport"], "64525": ["Formation of RNA Pol II elongation complex ", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "RNA Polymerase II Transcription Elongation", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "64526": ["Peroxisomal protein import"], "64527": ["Neutrophil degranulation"], "64528": ["Golgi Cisternae Pericentriolar Stack Reorganization", "COPII-mediated vesicle transport", "COPI-mediated anterograde transport"], "64529": ["Collagen degradation", "Trafficking and processing of endosomal TLR", "Assembly of collagen fibrils and other multimeric structures", "MHC class II antigen presentation", "Neutrophil degranulation"], "64533": ["Vitamins B6 activation to pyridoxal phosphate"], "64535": ["FGFR2b ligand binding and activation"], "64539": ["Respiratory electron transport", "Complex I biogenesis"], "64545": ["PIP3 activates AKT signaling", "Costimulation by the CD28 family", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "64546": ["Interleukin-12 signaling", "Interleukin-23 signaling"], "64547": ["Activation of BIM and translocation to mitochondria ", "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "NRAGE signals death through JNK"], "64549": ["Glycoprotein hormones"], "64551": ["MAPK6/MAPK4 signaling"], "64554": ["Amino acid transport across the plasma membrane"], "64558": ["Ca2+ pathway", "Asymmetric localization of PCP proteins", "Regulation of FZD by ubiquitination", "WNT5A-dependent internalization of FZD4", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "64561": ["Glycogen breakdown (glycogenolysis)"], "64562": ["Macroautophagy", "AMPK inhibits chREBP transcriptional activation activity", "Import of palmitoyl-CoA into the mitochondrial matrix", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Regulation of TP53 Activity through Phosphorylation"], "64563": ["Nephrin family interactions"], "64566": ["TCF dependent signaling in response to WNT", "WNT ligand biogenesis and trafficking", "Ca2+ pathway", "PCP/CE pathway", "Asymmetric localization of PCP proteins", "WNT5A-dependent internalization of FZD4", "WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "64625": ["Activation of BAD and translocation to mitochondria ", "Activation and oligomerization of BAK protein", "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "Activation, translocation and oligomerization of BAX", "Activation, myristolyation of BID and translocation to mitochondria"], "64627": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "SUMOylation of chromatin organization proteins", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "64631": ["Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Antigen processing: Ubiquitination & Proteasome degradation"], "64632": ["Insulin processing", "VxPx cargo-targeting to cilium"], "64639": ["Activation of BAD and translocation to mitochondria ", "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "NRAGE signals death through JNK"], "64640": ["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "64665": ["Synaptic adhesion-like molecules"], "64670": ["Macroautophagy", "TBC/RABGAPs"], "64672": ["Ion homeostasis", "Ion transport by P-type ATPases"], "64677": ["Androgen biosynthesis"], "64678": ["Golgi Associated Vesicle Biogenesis", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "Transferrin endocytosis and recycling"], "64680": ["Class B/2 (Secretin family receptors)", "G alpha (s) signalling events"], "64681": ["Neutrophil degranulation"], "64803": ["ADP signalling through P2Y purinoceptor 12", "P2Y receptors", "G alpha (i) signalling events"], "64822": ["Triglyceride catabolism"], "64827": ["Neutrophil degranulation"], "64828": ["Glycosphingolipid metabolism"], "64831": ["Iron uptake and transport"], "64832": ["Serotonin Neurotransmitter Release Cycle", "Norepinephrine Neurotransmitter Release Cycle", "Glutamate Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle", "Acetylcholine Neurotransmitter Release Cycle", "GABA synthesis, release, reuptake and degradation"], "64846": ["Sodium-coupled sulphate, di- and tri-carboxylate transporters"], "65023": ["Phase 1 - inactivation of fast Na+ channels"], "65024": ["Highly calcium permeable postsynaptic nicotinic acetylcholine receptors"], "65026": ["SUMO is transferred from E1 to E2 (UBE2I, UBC9)"], "65027": ["Deactivation of the beta-catenin transactivating complex"], "65029": ["Phase I - Functionalization of compounds", "Neutrophil degranulation"], "65032": ["Serotonin receptors", "G alpha (s) signalling events"], "65035": ["Nuclear Receptor transcription pathway"], "65036": ["Neurotransmitter clearance", "Synthesis of PC", "Synthesis, secretion, and deacylation of Ghrelin"], "65037": ["Cell surface interactions at the vascular wall"], "65039": ["Transport of fatty acids"], "65040": ["Neurexins and neuroligins"], "65044": ["O-linked glycosylation of mucins"], "65046": ["Retrograde neurotrophin signalling", "MHC class II antigen presentation", "Trafficking of GluR2-containing AMPA receptors", "Recycling pathway of L1", "WNT5A-dependent internalization of FZD4", "WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "VLDLR internalisation and degradation", "LDL clearance"], "65051": ["Intrinsic Pathway of Fibrin Clot Formation", "Common Pathway of Fibrin Clot Formation"], "65052": ["PI3K Cascade", "Macroautophagy", "Synthesis of PIPs at the early endosome membrane", "Toll Like Receptor 9 (TLR9) Cascade", "RHO GTPases Activate NADPH Oxidases"], "65054": ["Transport of glycerol from adipocytes to the liver by Aquaporins", "Passive transport by Aquaporins"], "65134": ["COPII-mediated vesicle transport", "Cargo concentration in the ER", "COPI-mediated anterograde transport", "Intra-Golgi traffic"], "65135": ["Pyrimidine catabolism"], "65137": ["UCH proteinases", "Ub-specific processing proteases", "DNA Damage Recognition in GG-NER", "Deposition of new CENPA-containing nucleosomes at the centromere"], "65138": ["UCH proteinases", "Ub-specific processing proteases"], "65139": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "65140": ["Olfactory Signaling Pathway"], "65151": ["Threonine catabolism"], "65156": ["Pyrimidine biosynthesis"], "65157": ["Signaling by Hippo"], "65164": ["Degradation of the extracellular matrix"], "65165": ["Pre-NOTCH Processing in Golgi", "COPII-mediated vesicle transport", "Cargo concentration in the ER", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "65166": ["Synthesis, secretion, and deacylation of Ghrelin"], "65172": ["Regulation of actin dynamics for phagocytic cup formation", "Sema3A PAK dependent Axon repulsion", "RHO GTPases activate PAKs"], "65179": ["Negative regulation of MAPK pathway", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "ESR-mediated signaling"], "65183": ["Sphingolipid de novo biosynthesis", "Alpha-oxidation of phytanate"], "65194": ["Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"], "65195": ["Voltage gated Potassium channels", "Phase 1 - inactivation of fast Na+ channels"], "65197": ["Neutrophil degranulation", "Intestinal hexose absorption"], "65198": ["Voltage gated Potassium channels"], "65199": ["Phase 1 - inactivation of fast Na+ channels"], "65200": ["Basigin interactions", "Proton-coupled monocarboxylate transport", "Pyruvate metabolism"], "65201": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "65202": ["Sodium-coupled sulphate, di- and tri-carboxylate transporters"], "65206": ["Ca2+ activated K+ channels"], "65208": ["CRMPs in Sema3A signaling"], "65248": ["Macroautophagy", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Regulation of TP53 Activity through Phosphorylation"], "65261": ["Regulation of actin dynamics for phagocytic cup formation", "B-WICH complex positively regulates rRNA expression"], "65271": ["N-Glycan antennae elongation"], "65272": ["TWIK related potassium channel (TREK)", "Phase 4 - resting membrane potential"], "65274": ["Transport of Mature mRNA derived from an Intron-Containing Transcript", "SUMOylation of DNA damage response and repair proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of DNA replication proteins"], "65275": ["G alpha (s) signalling events"], "65278": ["Sphingolipid de novo biosynthesis"], "652928": ["Glycerophospholipid biosynthesis", "Neutrophil degranulation"], "65984": ["Synthesis of Ketone Bodies"], "66016": ["Ca2+ activated K+ channels"], "66017": ["PI3K Cascade", "PIP3 activates AKT signaling", "FGFR4 ligand binding and activation", "FGFR3b ligand binding and activation", "FGFR3c ligand binding and activation", "FGFR1c ligand binding and activation", "FGFR2c ligand binding and activation", "Phospholipase C-mediated cascade: FGFR1", "Phospholipase C-mediated cascade; FGFR2", "Phospholipase C-mediated cascade; FGFR3", "Phospholipase C-mediated cascade; FGFR4", "Downstream signaling of activated FGFR1", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "PI-3K cascade:FGFR3", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "PI-3K cascade:FGFR4", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "66018": ["Signaling by PDGF"], "66020": ["Glycolysis"], "66022": ["Voltage gated Potassium channels"], "66023": ["RAF/MAP kinase cascade", "RET signaling"], "66024": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "66025": ["G alpha (q) signalling events", "G alpha (i) signalling events", "Lysosphingolipid and LPA receptors"], "66026": ["TRP channels"], "664630": ["Amino acid transport across the plasma membrane", "Na+/Cl- dependent neurotransmitter transporters"], "678749": ["Acyl chain remodeling of DAG and TAG"], "678759": ["Respiratory electron transport", "Complex I biogenesis"], "679028": ["NOTCH1 Intracellular Domain Regulates Transcription", "NOTCH2 intracellular domain regulates transcription", "Notch-HLH transcription pathway", "RUNX3 regulates NOTCH signaling"], "679082": ["Rho GTPase cycle"], "679110": ["Beta-catenin phosphorylation cascade", "Disassembly of the destruction complex and recruitment of AXIN to the membrane"], "679140": ["mRNA decay by 3' to 5' exoribonuclease", "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "KSRP (KHSRP) binds and destabilizes mRNA", "Major pathway of rRNA processing in the nucleolus and cytosol"], "679312": ["Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "Recruitment of NuMA to mitotic centrosomes", "Recycling pathway of L1", "Hedgehog 'off' state", "Cilium Assembly", "Intraflagellar transport", "RHO GTPases activate IQGAPs", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "Carboxyterminal post-translational modifications of tubulin", "Kinesins"], "679342": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Deposition of new CENPA-containing nucleosomes at the centromere", "Mitotic Prometaphase"], "679520": ["Arachidonic acid metabolism", "Wax biosynthesis"], "679532": ["Synthesis of very long-chain fatty acyl-CoAs"], "679539": ["NOD1/2 Signaling Pathway", "Downstream TCR signaling", "FCERI mediated NF-kB activation", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "CLEC7A (Dectin-1) signaling", "Interleukin-1 signaling", "IRAK1 recruits IKK complex", "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "Antigen processing: Ubiquitination & Proteasome degradation"], "679668": ["Neurexins and neuroligins"], "679692": ["Acyl chain remodelling of PG"], "679739": ["Respiratory electron transport", "Complex I biogenesis"], "679787": ["DAP12 interactions", "Neutrophil degranulation"], "679837": ["Invadopodia formation"], "679886": ["Macroautophagy", "Endosomal Sorting Complex Required For Transport (ESCRT)"], "679890": ["mRNA Splicing - Major Pathway"], "679894": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA 3'-end processing"], "679934": ["Regulation of actin dynamics for phagocytic cup formation", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate WASPs and WAVEs"], "679957": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (i) signalling events"], "679958": ["Stimuli-sensing channels"], "679975": ["Class A/1 (Rhodopsin-like receptors)", "G alpha (i) signalling events"], "679994": ["Interleukin-7 signaling", "PRC2 methylates histones and DNA", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "Chromatin modifying enzymes", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression", "Factors involved in megakaryocyte development and platelet production"], "680006": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "680014": ["Establishment of Sister Chromatid Cohesion"], "680021": ["Glyoxylate metabolism and glycine degradation"], "680036": ["Protein repair"], "680060": ["Keratinization"], "680066": ["Depolymerisation of the Nuclear Lamina"], "680071": ["Keratinization"], "680076": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "680104": ["Keratinization"], "680127": ["MyD88:MAL(TIRAP) cascade initiated on plasma membrane"], "680136": ["Keratinization"], "680149": ["Activation of G protein gated Potassium channels", "G-protein activation", "Activation of the phototransduction cascade", "Inactivation, recovery and regulation of the phototransduction cascade", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Olfactory Signaling Pathway", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42", "Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "680152": ["Keratinization"], "680188": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "680210": ["Post-translational modification: synthesis of GPI-anchored proteins"], "680248": ["Synthesis of pyrophosphates in the cytosol"], "680264": ["Sperm Motility And Taxes"], "680308": ["Metabolism of folate and pterines"], "680309": ["snRNP Assembly", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "680312": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HATs acetylate histones", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "E3 ubiquitin ligases ubiquitinate target proteins", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "680396": ["Keratinization"], "680403": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HATs acetylate histones", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "E3 ubiquitin ligases ubiquitinate target proteins", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "680407": ["Anchoring of the basal body to the plasma membrane"], "680409": ["Proline catabolism"], "680415": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "680424": ["E3 ubiquitin ligases ubiquitinate target proteins", "Peroxisomal protein import"], "680466": ["Role of phospholipids in phagocytosis"], "680476": ["Golgi Associated Vesicle Biogenesis"], "680477": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "680493": ["B-WICH complex positively regulates rRNA expression", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase I Transcription Termination"], "680498": ["Interleukin-7 signaling", "PRC2 methylates histones and DNA", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "Chromatin modifying enzymes", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression", "Factors involved in megakaryocyte development and platelet production"], "680537": ["PKMTs methylate histone lysines", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "G2/M DNA damage checkpoint"], "680551": ["VLDL assembly", "VLDL clearance"], "680594": ["Synthesis of diphthamide-EEF2"], "680602": ["Transport of fatty acids"], "680609": ["Interleukin-35 Signalling", "Interleukin-27 signaling"], "680668": ["Vitamin B1 (thiamin) metabolism"], "680717": ["Generic Transcription Pathway"], "680718": ["Collagen degradation", "Degradation of the extracellular matrix", "Trafficking and processing of endosomal TLR", "Assembly of collagen fibrils and other multimeric structures", "MHC class II antigen presentation", "RUNX1 regulates transcription of genes involved in differentiation of keratinocytes"], "680737": ["Cleavage of Growing Transcript in the Termination Region ", "SLBP independent Processing of Histone Pre-mRNAs", "snRNP Assembly", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"], "680747": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "680835": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "680891": ["mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "680910": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "680912": ["Sperm Motility And Taxes"], "680915": ["Cleavage of the damaged pyrimidine ", "Displacement of DNA glycosylase by APEX1"], "680971": ["Synthesis of PA"], "680991": ["Recruitment of mitotic centrosome proteins and complexes", "Recruitment of NuMA to mitotic centrosomes"], "681012": ["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "681033": ["Post-translational modification: synthesis of GPI-anchored proteins"], "681050": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "681059": ["Endosomal Sorting Complex Required For Transport (ESCRT)"], "681062": ["Cleavage of Growing Transcript in the Termination Region ", "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"], "681070": ["Cell surface interactions at the vascular wall"], "681112": ["Interleukin-20 family signaling"], "681123": ["Pink/Parkin Mediated Mitophagy"], "681126": ["Keratinization", "Formation of the cornified envelope"], "681178": ["RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "681182": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "681185": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Deposition of new CENPA-containing nucleosomes at the centromere", "Mitotic Prometaphase"], "681190": ["Phase 3 - rapid repolarisation", "Phase 2 - plateau phase"], "681194": ["Post-translational modification: synthesis of GPI-anchored proteins"], "681211": ["Triglyceride biosynthesis"], "681236": ["CD22 mediated BCR regulation", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "681309": ["Signaling by PDGF"], "681337": ["Beta-oxidation of very long chain fatty acids", "Peroxisomal protein import"], "681341": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "681418": ["Respiratory electron transport", "Complex I biogenesis"], "681429": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "681458": ["Fatty acyl-CoA biosynthesis"], "681544": ["Platelet degranulation ", "Dissolution of Fibrin Clot"], "681740": ["PRC2 methylates histones and DNA"], "681896": ["Organic anion transporters"], "681913": ["Glutathione conjugation", "Regulation of pyruvate dehydrogenase (PDH) complex", "Phenylalanine and tyrosine catabolism"], "682033": ["Inhibition of replication initiation of damaged DNA by RB1/E2F1", "Cyclin D associated events in G1", "Cyclin A/B1/B2 associated events during G2/M transition"], "682457": ["Other interleukin signaling"], "682507": ["Regulation of actin dynamics for phagocytic cup formation", "NOSTRIN mediated eNOS trafficking", "Nephrin family interactions", "EPHB-mediated forward signaling", "DCC mediated attractive signaling", "RHO GTPases Activate WASPs and WAVEs", "Clathrin-mediated endocytosis"], "682793": ["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "682902": ["RNA Polymerase II Pre-transcription Events", "Regulation of TP53 Activity through Phosphorylation", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance"], "683077": ["Antigen processing: Ubiquitination & Proteasome degradation"], "683163": ["TNFs bind their physiological receptors"], "683206": ["NOD1/2 Signaling Pathway", "TNFR1-induced proapoptotic signaling", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "Ovarian tumor domain proteases", "Negative regulators of DDX58/IFIH1 signaling"], "683381": ["Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"], "683470": ["Ligand-receptor interactions", "Activation of SMO"], "683519": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "683613": ["Keratinization", "Formation of the cornified envelope"], "683630": ["Methylation", "Ub-specific processing proteases"], "683667": ["Stimuli-sensing channels", "Reduction of cytosolic Ca++ levels", "Sodium/Calcium exchangers", "Ion homeostasis", "Ion transport by P-type ATPases"], "683722": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "683849": ["Collagen degradation", "Activation of Matrix Metalloproteinases", "Cobalamin (Cbl, vitamin B12) transport and metabolism", "Neutrophil degranulation", "Antimicrobial peptides"], "683927": ["Cleavage of Growing Transcript in the Termination Region ", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Processing of Intronless Pre-mRNAs"], "683983": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA damage response and repair proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of DNA replication proteins", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "684111": ["CDC6 association with the ORC:origin complex", "Cyclin D associated events in G1"], "684148": ["mRNA decay by 5' to 3' exoribonuclease", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "684179": ["Olfactory Signaling Pathway"], "684208": ["Olfactory Signaling Pathway"], "684314": ["Fructose catabolism"], "684425": ["Purine ribonucleoside monophosphate biosynthesis"], "684439": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "RHO GTPases Activate Formins", "Deposition of new CENPA-containing nucleosomes at the centromere", "Mitotic Prometaphase"], "684440": ["Trafficking and processing of endosomal TLR", "Toll Like Receptor 7/8 (TLR7/8) Cascade", "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "MyD88 dependent cascade initiated on endosome"], "684509": ["Respiratory electron transport", "Complex I biogenesis"], "684536": ["Glycosphingolipid metabolism"], "684558": ["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "684589": ["Keratinization"], "684762": ["Interleukin-7 signaling", "PRC2 methylates histones and DNA", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "PKMTs methylate histone lysines", "HDMs demethylate histones", "HATs acetylate histones", "RMTs methylate histone arginines", "Chromatin modifying enzymes", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression", "Factors involved in megakaryocyte development and platelet production"], "684773": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Metalloprotease DUBs", "Deposition of new CENPA-containing nucleosomes at the centromere", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "684797": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HATs acetylate histones", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "E3 ubiquitin ligases ubiquitinate target proteins", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "684979": ["HS-GAG biosynthesis"], "684988": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "685029": ["Antigen processing: Ubiquitination & Proteasome degradation"], "685048": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "685055": ["Activation of ATR in response to replication stress", "Regulation of HSF1-mediated heat shock response", "HDR through Single Strand Annealing (SSA)", "Processing of DNA double-strand break ends", "Presynaptic phase of homologous DNA pairing and strand exchange", "Fanconi Anemia Pathway"], "685072": ["Nuclear Receptor transcription pathway", "Signaling by Retinoic Acid"], "685076": ["Glycogen synthesis", "Glycolysis"], "685144": ["COPII-mediated vesicle transport", "MHC class II antigen presentation", "Cargo concentration in the ER", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "685152": ["Ion transport by P-type ATPases"], "685157": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "685161": ["Antimicrobial peptides"], "685179": ["RMTs methylate histone arginines", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "685232": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "685243": ["Chemokine receptors bind chemokines"], "685284": ["Intraflagellar transport"], "685325": ["Glyoxylate metabolism and glycine degradation", "Peroxisomal protein import"], "685332": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "685451": ["G-protein activation", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42"], "685465": ["RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "685472": ["Neurexins and neuroligins"], "685474": ["Regulation of TP53 Activity through Association with Co-factors", "Transcriptional  activation of  cell cycle inhibitor p21 "], "685539": ["RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter"], "685567": ["mRNA Splicing - Major Pathway"], "685579": ["Interconversion of nucleotide di- and triphosphates"], "685620": ["Pink/Parkin Mediated Mitophagy"], "685750": ["RA biosynthesis pathway"], "685834": ["Generic Transcription Pathway"], "685840": ["Interleukin-20 family signaling"], "685844": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"], "685860": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "685867": ["Smooth Muscle Contraction", "RHO GTPases activate PAKs"], "685883": ["Smooth Muscle Contraction", "RHO GTPases activate PAKs"], "685909": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Deposition of new CENPA-containing nucleosomes at the centromere", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "685963": ["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "685999": ["Histidine catabolism"], "686019": ["Stimuli-sensing channels", "Ion homeostasis"], "686310": ["EPH-Ephrin signaling", "EPHB-mediated forward signaling", "Ephrin signaling", "EPH-ephrin mediated repulsion of cells"], "686326": ["Interferon alpha/beta signaling", "Regulation of IFNA signaling"], "686412": ["Regulation of PTEN gene transcription"], "686505": ["Macroautophagy"], "686539": ["Platelet degranulation "], "686683": ["Olfactory Signaling Pathway"], "686781": ["Regulation of TP53 Activity through Association with Co-factors"], "686999": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "687071": ["Synthesis of PE"], "687088": ["Olfactory Signaling Pathway"], "687105": ["NRAGE signals death through JNK", "Rho GTPase cycle"], "687208": ["Endosomal Sorting Complex Required For Transport (ESCRT)"], "687364": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "687424": ["Activated NOTCH1 Transmits Signal to the Nucleus"], "687631": ["Keratinization"], "687696": ["Metalloprotease DUBs"], "687711": ["Cleavage of Growing Transcript in the Termination Region ", "SLBP independent Processing of Histone Pre-mRNAs", "snRNP Assembly", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"], "687813": ["Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway"], "687861": ["Cobalamin (Cbl, vitamin B12) transport and metabolism"], "687880": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "688228": ["Striated Muscle Contraction"], "688288": ["Cleavage of Growing Transcript in the Termination Region ", "ISG15 antiviral mechanism", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Deadenylation of mRNA", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "688297": ["Activation of the phototransduction cascade", "Inactivation, recovery and regulation of the phototransduction cascade", "Ca2+ pathway"], "688328": ["Generic Transcription Pathway"], "688429": ["Rho GTPase cycle"], "688466": ["TNFR1-induced proapoptotic signaling", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "Ub-specific processing proteases"], "688478": ["Neddylation"], "688536": ["Conjugation of benzoate with glycine"], "688555": ["Macroautophagy"], "688605": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "688673": ["O-linked glycosylation"], "688705": ["Effects of PIP2 hydrolysis"], "688721": ["Synaptic adhesion-like molecules"], "688730": ["G alpha (s) signalling events", "Neutrophil degranulation"], "688828": ["Phosphate bond hydrolysis by NUDT proteins"], "688845": ["Recognition of DNA damage by PCNA-containing replication complex"], "688862": ["Synthesis of pyrophosphates in the cytosol"], "688912": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "688913": ["Neddylation"], "688993": ["Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "688996": ["TWIK-related alkaline pH activated K+ channel (TALK)", "Phase 4 - resting membrane potential"], "689025": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "689055": ["HDR through Homologous Recombination (HRR)", "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "Resolution of D-loop Structures through Holliday Junction Intermediates", "Homologous DNA Pairing and Strand Exchange"], "689064": ["Erythrocytes take up carbon dioxide and release oxygen", "Erythrocytes take up oxygen and release carbon dioxide", "Scavenging of heme from plasma", "Neutrophil degranulation"], "689103": ["Stimuli-sensing channels"], "689116": ["Cleavage of Growing Transcript in the Termination Region ", "SLBP independent Processing of Histone Pre-mRNAs", "Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "RNA Polymerase II Pre-transcription Events", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "mRNA 3'-end processing", "Processing of Capped Intron-Containing Pre-mRNA", "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "Processing of Intronless Pre-mRNAs", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "689134": ["XBP1(S) activates chaperone genes"], "689161": ["Macroautophagy"], "689197": ["Protein methylation"], "689226": ["Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "Antigen processing: Ubiquitination & Proteasome degradation"], "689230": ["Formation of the cornified envelope"], "689256": ["Golgi Associated Vesicle Biogenesis"], "689284": ["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "689296": ["Deposition of new CENPA-containing nucleosomes at the centromere"], "689314": ["NOD1/2 Signaling Pathway", "p38MAPK events", "ERK/MAPK targets", "Oxidative Stress Induced Senescence", "CDO in myogenesis", "DSCAM interactions", "VEGFA-VEGFR2 Pathway", "activated TAK1 mediates p38 MAPK activation", "Activation of the AP-1 family of transcription factors", "Regulation of TP53 Activity through Phosphorylation"], "689377": ["RAB geranylgeranylation"], "689388": ["Neutrophil degranulation"], "689399": ["Deposition of new CENPA-containing nucleosomes at the centromere"], "689404": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "689432": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "689523": ["G0 and Early G1"], "689582": ["HDMs demethylate histones"], "689756": ["Ovarian tumor domain proteases"], "689779": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "689820": ["Condensation of Prophase Chromosomes", "PKMTs methylate histone lysines", "Regulation of TP53 Activity through Methylation"], "689852": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "689883": ["PKMTs methylate histone lysines"], "689890": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "mRNA 3'-end processing"], "689938": ["Respiratory electron transport", "Complex I biogenesis"], "689954": ["PKMTs methylate histone lysines"], "690037": ["Post-translational modification: synthesis of GPI-anchored proteins"], "690043": ["SUMOylation of DNA damage response and repair proteins", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "G2/M DNA damage checkpoint"], "690050": ["Methylation"], "690073": ["COPI-dependent Golgi-to-ER retrograde traffic"], "690076": ["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "DAP12 interactions"], "690102": ["Metalloprotease DUBs"], "690130": ["Rho GTPase cycle", "Neutrophil degranulation"], "690131": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Metalloprotease DUBs", "Deposition of new CENPA-containing nucleosomes at the centromere", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "690158": ["G alpha (i) signalling events", "Formyl peptide receptors bind formyl peptides and many other ligands"], "690163": ["Utilization of Ketone Bodies"], "690198": ["G alpha (i) signalling events", "Formyl peptide receptors bind formyl peptides and many other ligands"], "690209": ["APC-Cdc20 mediated degradation of Nek2A", "Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "690252": ["COPII-mediated vesicle transport", "Cargo concentration in the ER"], "690253": ["TP53 Regulates Transcription of Genes Involved in Cytochrome C Release"], "690254": ["RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "690263": ["Neutrophil degranulation"], "690297": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "690303": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA Splicing - Major Pathway", "mRNA 3'-end processing", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "690315": ["ABC-family proteins mediated transport"], "690334": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "690386": ["Keratinization"], "690388": ["Acyl chain remodelling of PS", "Acyl chain remodelling of PG", "Synthesis of PA"], "690407": ["Intra-Golgi traffic", "RAB geranylgeranylation"], "690441": ["Formation of ATP by chemiosmotic coupling", "Cristae formation"], "690448": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "690450": ["B-WICH complex positively regulates rRNA expression", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase I Transcription Termination"], "690460": ["Keratinization"], "690468": ["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "690472": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "690478": ["Keratinization"], "690481": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "690516": ["Signaling by BMP", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "Asymmetric localization of PCP proteins", "Hedgehog 'on' state", "Regulation of RUNX3 expression and activity", "Antigen processing: Ubiquitination & Proteasome degradation"], "690538": ["RHO GTPases Activate Formins"], "690572": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "690610": ["Acyl chain remodelling of PC"], "690728": ["RNA polymerase II transcribes snRNA genes"], "690743": ["TRP channels", "RIPK1-mediated regulated necrosis"], "690745": ["Phase I - Functionalization of compounds"], "690769": ["Antigen processing: Ubiquitination & Proteasome degradation"], "690795": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Deposition of new CENPA-containing nucleosomes at the centromere", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "690825": ["Activation of G protein gated Potassium channels", "G-protein activation", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42", "Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "690895": ["Generic Transcription Pathway"], "690914": ["O-linked glycosylation of mucins", "Termination of O-glycan biosynthesis"], "690919": ["Signaling by ERBB2", "Signaling by ERBB4", "SHC1 events in ERBB2 signaling", "PI3K events in ERBB4 signaling", "SHC1 events in ERBB4 signaling", "PIP3 activates AKT signaling", "GRB2 events in ERBB2 signaling", "PI3K events in ERBB2 signaling", "RAF/MAP kinase cascade", "ERBB2 Regulates Cell Motility", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "ERBB2 Activates PTK6 Signaling", "Downregulation of ERBB2 signaling"], "690945": ["Neutrophil degranulation", "Pentose phosphate pathway"], "690961": ["COPI-mediated anterograde transport", "Intra-Golgi traffic", "Retrograde transport at the Trans-Golgi-Network"], "690966": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase I Transcription Termination", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Pol II CTD phosphorylation and interaction with CE", "Estrogen-dependent gene expression"], "690987": ["Glycogen synthesis"], "691018": ["Estrogen biosynthesis"], "691042": ["RAB GEFs exchange GTP for GDP on RABs"], "691120": ["Post-translational modification: synthesis of GPI-anchored proteins"], "691171": ["Hedgehog 'on' state"], "691209": ["Cation-coupled Chloride cotransporters"], "691231": ["snRNP Assembly"], "691259": ["Post-translational modification: synthesis of GPI-anchored proteins"], "691278": ["TP53 Regulates Transcription of Genes Involved in Cytochrome C Release"], "691312": ["Fatty acids", "Miscellaneous substrates", "Eicosanoids", "Synthesis of Leukotrienes (LT) and Eoxins (EX)"], "691318": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Degradation of beta-catenin by the destruction complex", "Beta-catenin phosphorylation cascade", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "CTLA4 inhibitory signaling", "RHO GTPases Activate Formins", "RAF activation", "Regulation of TP53 Degradation", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Mitotic Prometaphase"], "691379": ["RNA polymerase II transcribes snRNA genes"], "691393": ["Mitochondrial translation elongation", "Mitochondrial translation termination"], "691394": ["Dermatan sulfate biosynthesis"], "691488": ["PRC2 methylates histones and DNA", "Condensation of Prophase Chromosomes", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "HATs acetylate histones", "SIRT1 negatively regulates rRNA expression", "NoRC negatively regulates rRNA expression", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "Nonhomologous End-Joining (NHEJ)", "Deposition of new CENPA-containing nucleosomes at the centromere", "G2/M DNA damage checkpoint", "RNA Polymerase I Promoter Opening", "RNA Polymerase I Chain Elongation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Estrogen-dependent gene expression"], "691501": ["RNA polymerase II transcribes snRNA genes", "RNA Polymerase III Transcription Initiation From Type 3 Promoter"], "691516": ["Interleukin-17 signaling"], "691538": ["mRNA Splicing - Minor Pathway"], "691610": ["Generic Transcription Pathway"], "691668": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "691670": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"], "691695": ["Activation, myristolyation of BID and translocation to mitochondria"], "691774": ["G alpha (q) signalling events", "P2Y receptors"], "691853": ["Heme biosynthesis"], "691857": ["Formation of the beta-catenin:TCF transactivating complex", "Deactivation of the beta-catenin transactivating complex"], "691905": ["Acyl chain remodelling of PC", "Acyl chain remodelling of PS", "Acyl chain remodelling of PE", "Acyl chain remodelling of PI", "Acyl chain remodelling of PG", "Hydrolysis of LPC", "Synthesis of PA"], "691947": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit"], "691966": ["Sulfide oxidation to sulfate"], "691979": ["Establishment of Sister Chromatid Cohesion"], "691984": ["A tetrasaccharide linker sequence is required for GAG synthesis", "HS-GAG biosynthesis", "HS-GAG degradation", "Retinoid metabolism and transport"], "691992": ["Intrinsic Pathway of Fibrin Clot Formation", "GP1b-IX-V activation signalling", "Platelet Adhesion to exposed collagen", "Platelet Aggregation (Plug Formation)"], "692032": ["Recruitment of mitotic centrosome proteins and complexes", "Recruitment of NuMA to mitotic centrosomes"], "751787": ["Vitamin B2 (riboflavin) metabolism"], "767613": ["Leukotriene receptors", "G alpha (q) signalling events", "P2Y receptors", "G alpha (i) signalling events"], "78956": ["Phase 0 - rapid depolarisation"], "78957": ["Neurexins and neuroligins"], "78959": ["Glutathione conjugation", "Formation of xylulose-5-phosphate"], "78963": ["Neutrophil degranulation", "Regulation of the apoptosome activity"], "78964": ["Orexin and neuropeptides FF and QRFP bind to their respective receptors", "G alpha (q) signalling events"], "78968": ["Regulation of cholesterol biosynthesis by SREBP (SREBF)"], "78971": ["NOD1/2 Signaling Pathway", "RIPK1-mediated regulated necrosis", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "TNFR2 non-canonical NF-kB pathway", "Regulation of necroptotic cell death", "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "Ub-specific processing proteases"], "78973": ["SUMO is proteolytically processed"], "78976": ["Peptide ligand-binding receptors", "G alpha (q) signalling events"], "78980": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "78983": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "78985": ["G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)"], "79032": ["Miscellaneous transport and binding events"], "79110": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "79111": ["Recycling of bile acids and salts"], "79112": ["Synthesis of glycosylphosphatidylinositol (GPI)"], "79113": ["FCGR activation", "Platelet sensitization by LDL", "Neutrophil degranulation"], "79114": ["PI3K Cascade", "PIP3 activates AKT signaling", "FGFR1b ligand binding and activation", "FGFR1c ligand binding and activation", "FGFR1c and Klotho ligand binding and activation", "Signal transduction by L1", "Phospholipase C-mediated cascade: FGFR1", "Downstream signaling of activated FGFR1", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "Negative regulation of FGFR1 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "79115": ["Signaling by ROBO receptors", "RHO GTPases Activate Formins"], "79116": ["Displacement of DNA glycosylase by APEX1", "POLB-Dependent Long Patch Base Excision Repair", "Resolution of AP sites via the multiple-nucleotide patch replacement pathway", "PCNA-Dependent Long Patch Base Excision Repair", "Abasic sugar-phosphate removal via the single-nucleotide replacement pathway", "Resolution of Abasic Sites (AP sites)"], "79117": ["COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "79120": ["VxPx cargo-targeting to cilium", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "79121": ["TBC/RABGAPs", "Clathrin-mediated endocytosis", "MET receptor recycling"], "79122": ["Pregnenolone biosynthesis", "Endogenous sterols", "Electron transport from NADPH to Ferredoxin"], "79123": ["Stimuli-sensing channels"], "791259": ["Reversible hydration of carbon dioxide"], "79129": ["Cross-presentation of particulate exogenous antigens (phagosomes)", "Detoxification of Reactive Oxygen Species", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate NADPH Oxidases", "Neutrophil degranulation"], "79130": ["Neutrophil degranulation", "GABA synthesis, release, reuptake and degradation"], "79131": ["Triglyceride catabolism"], "79208": ["EPH-Ephrin signaling", "EPHA-mediated growth cone collapse", "EPH-ephrin mediated repulsion of cells"], "79209": ["Neutrophil degranulation", "Regulation of PTEN stability and activity"], "79210": ["Signaling by BMP", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "79211": ["GABA A receptor activation"], "79212": ["Na+/Cl- dependent neurotransmitter transporters", "Reuptake of GABA"], "79213": ["Na+/Cl- dependent neurotransmitter transporters", "Creatine metabolism", "Reuptake of GABA"], "79214": ["COPI-independent Golgi-to-ER retrograde traffic", "O-linked glycosylation of mucins"], "79217": ["Gap junction assembly"], "79218": ["Activation of G protein gated Potassium channels", "G-protein activation", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42", "Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "79223": ["Triglyceride biosynthesis"], "79224": ["Intrinsic Pathway of Fibrin Clot Formation", "Common Pathway of Fibrin Clot Formation", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "79227": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA 3'-end processing"], "79238": ["Synthesis of Ketone Bodies", "Peroxisomal protein import"], "79239": ["Heme degradation", "Neutrophil degranulation", "Iron uptake and transport"], "79240": ["AKT phosphorylates targets in the nucleus", "Nuclear Receptor transcription pathway"], "79242": ["Synthesis of Lipoxins (LX)"], "79244": ["Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Beta-oxidation of pristanoyl-CoA", "Peroxisomal protein import"], "79245": ["Regulation of HSF1-mediated heat shock response", "HSF1 activation", "Attenuation phase", "HSF1-dependent transactivation"], "79246": ["Neurotransmitter receptors and postsynaptic signal transmission"], "79249": ["Regulation of actin dynamics for phagocytic cup formation", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate WASPs and WAVEs"], "79250": ["Citric acid cycle (TCA cycle)"], "79251": ["Amino acid synthesis and interconversion (transamination)"], "79252": ["O-glycosylation of TSR domain-containing proteins"], "79256": ["AUF1 (hnRNP D0) binds and destabilizes mRNA", "mRNA Splicing - Major Pathway"], "79425": ["Stimuli-sensing channels"], "79429": ["Signaling by PDGF"], "79430": ["Stimuli-sensing channels"], "79434": ["TBC/RABGAPs", "RAB geranylgeranylation"], "79462": ["Degradation of cysteine and homocysteine", "Detoxification of Reactive Oxygen Species"], "79557": ["Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "Highly calcium permeable nicotinic acetylcholine receptors"], "80722": ["Negative regulation of TCF-dependent signaling by WNT ligand antagonists"], "80773": ["Phase I - Functionalization of compounds"], "80841": ["Triglyceride catabolism"], "80843": ["XBP1(S) activates chaperone genes"], "80846": ["mRNA Splicing - Major Pathway"], "80878": ["Basigin interactions", "Proton-coupled monocarboxylate transport", "Pyruvate metabolism"], "80881": ["XBP1(S) activates chaperone genes"], "80897": ["Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "80899": ["Recycling of bile acids and salts", "Transport of organic anions"], "80900": ["Recycling of bile acids and salts", "Transport of organic anions"], "81008": ["Laminin interactions", "ECM proteoglycans"], "81504": ["PI3K Cascade", "SOS-mediated signalling", "SHC1 events in ERBB4 signaling", "PIP3 activates AKT signaling", "Spry regulation of FGF signaling", "Signaling by SCF-KIT", "Regulation of KIT signaling", "Signalling to RAS", "GRB2 events in EGFR signaling", "GAB1 signalosome", "SHC1 events in EGFR signaling", "EGFR downregulation", "Downstream signal transduction", "GRB2 events in ERBB2 signaling", "PI3K events in ERBB2 signaling", "Regulation of actin dynamics for phagocytic cup formation", "Tie2 Signaling", "EGFR Transactivation by Gastrin", "DAP12 signaling", "SHC-related events triggered by IGF1R", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "GRB2:SOS provides linkage to MAPK signaling for Integrins ", "NCAM signaling for neurite out-growth", "Costimulation by the CD28 family", "CD28 dependent Vav1 pathway", "Signal regulatory protein family interactions", "SHC-mediated cascade:FGFR1", "PI-3K cascade:FGFR1", "FRS-mediated FGFR1 signaling", "PI-3K cascade:FGFR2", "SHC-mediated cascade:FGFR2", "FRS-mediated FGFR2 signaling", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "PI-3K cascade:FGFR3", "FRS-mediated FGFR4 signaling", "SHC-mediated cascade:FGFR4", "PI-3K cascade:FGFR4", "Negative regulation of FGFR1 signaling", "Negative regulation of FGFR2 signaling", "Negative regulation of FGFR3 signaling", "Negative regulation of FGFR4 signaling", "RHO GTPases Activate WASPs and WAVEs", "RAF/MAP kinase cascade", "Negative regulation of MET activity", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Signal attenuation", "Insulin receptor signalling cascade", "MET activates RAS signaling", "MET activates PI3K/AKT signaling", "RET signaling", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "MET activates PTPN11", "MET activates RAP1 and RAC1", "MET receptor recycling", "Interleukin-15 signaling", "Erythropoietin activates RAS", "Activated NTRK2 signals through FRS2 and FRS3", "Interleukin receptor SHC signaling", "Regulation of signaling by CBL", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "81507": ["Signaling by BMP"], "81509": ["Peptide ligand-binding receptors", "G alpha (q) signalling events", "G alpha (i) signalling events"], "81511": ["GPVI-mediated activation cascade", "Generation of second messenger molecules", "DAP12 signaling", "Fc epsilon receptor (FCERI) signaling", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "RAF/MAP kinase cascade"], "81513": ["POLB-Dependent Long Patch Base Excision Repair", "Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)", "PCNA-Dependent Long Patch Base Excision Repair", "Gap-filling DNA repair synthesis and ligation in TC-NER", "Processive synthesis on the lagging strand"], "81515": ["GPVI-mediated activation cascade", "Signaling by SCF-KIT", "Regulation of KIT signaling", "Cell surface interactions at the vascular wall", "FCGR activation", "Fc epsilon receptor (FCERI) signaling", "FCERI mediated Ca+2 mobilization", "FCERI mediated NF-kB activation", "CD28 co-stimulation", "CTLA4 inhibitory signaling", "EPHB-mediated forward signaling", "EPHA-mediated growth cone collapse", "EPH-ephrin mediated repulsion of cells", "CD209 (DC-SIGN) signaling", "CD22 mediated BCR regulation", "Cyclin D associated events in G1", "Platelet Adhesion to exposed collagen", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "Erythropoietin activates RAS", "Regulation of signaling by CBL", "Growth hormone receptor signaling"], "81516": ["Signaling by BMP", "Downregulation of TGF-beta receptor signaling", "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "Ub-specific processing proteases"], "81517": ["NOTCH2 Activation and Transmission of Signal to the Nucleus"], "81518": ["CDO in myogenesis"], "81519": ["N-glycan trimming and elongation in the cis-Golgi"], "81525": ["Activation of NF-kappaB in B cells", "RIP-mediated NFkB activation via ZBP1", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "TRAF6 mediated NF-kB activation"], "81527": ["Neurophilin interactions with VEGF and VEGFR"], "81528": ["Cleavage of the damaged pyrimidine ", "Cleavage of the damaged purine", "Displacement of DNA glycosylase by APEX1", "APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway"], "81531": ["Signaling by ROBO receptors", "RHO GTPases Activate Formins"], "81574": ["Phase 0 - rapid depolarisation"], "81613": ["Fibronectin matrix formation", "Post-translational modification: synthesis of GPI-anchored proteins", "Cell surface interactions at the vascular wall", "Neutrophil degranulation"], "81632": ["Degradation of GABA"], "81634": ["Platelet degranulation ", "Regulation of cytoskeletal remodeling and cell spreading by IPP complex components"], "81637": ["Retrograde neurotrophin signalling", "MHC class II antigen presentation", "Trafficking of GluR2-containing AMPA receptors", "Recycling pathway of L1", "WNT5A-dependent internalization of FZD4", "WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "Neutrophil degranulation", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "VLDLR internalisation and degradation", "LDL clearance"], "81638": ["Peptide ligand-binding receptors", "G alpha (q) signalling events", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "81639": ["Synthesis of Leukotrienes (LT) and Eoxins (EX)", "Synthesis of 12-eicosatetraenoic acid derivatives", "Synthesis of 15-eicosatetraenoic acid derivatives", "Biosynthesis of E-series 18(R)-resolvins"], "81640": ["Metabolism of polyamines"], "81641": ["Neutrophil degranulation"], "81642": ["ABC-family proteins mediated transport"], "81643": ["Purine ribonucleoside monophosphate biosynthesis"], "81645": ["Muscarinic acetylcholine receptors", "G alpha (i) signalling events", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "81646": ["AKT phosphorylates targets in the nucleus", "CREB phosphorylation", "NCAM signaling for neurite out-growth", "CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling", "Gastrin-CREB signalling pathway via PKC and MAPK"], "81647": ["HATs acetylate histones", "Activation of the AP-1 family of transcription factors", "Estrogen-dependent gene expression"], "81648": ["Class B/2 (Secretin family receptors)", "G alpha (s) signalling events"], "81649": ["NOD1/2 Signaling Pathway", "p38MAPK events", "ERK/MAPK targets", "Oxidative Stress Induced Senescence", "CDO in myogenesis", "DSCAM interactions", "ADP signalling through P2Y purinoceptor 1", "Platelet sensitization by LDL", "VEGFA-VEGFR2 Pathway", "activated TAK1 mediates p38 MAPK activation", "Activation of the AP-1 family of transcription factors", "Neutrophil degranulation", "Regulation of TP53 Activity through Phosphorylation"], "81650": ["WNT mediated activation of DVL", "Signal transduction by L1", "Neutrophil degranulation", "Regulation of TP53 Activity through Phosphorylation", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "Regulation of PTEN stability and activity"], "81654": ["Regulation of pyruvate dehydrogenase (PDH) complex", "Glyoxylate metabolism and glycine degradation", "Signaling by Retinoic Acid", "Pyruvate metabolism"], "81655": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "MHC class II antigen presentation", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "RHO GTPases Activate Formins", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase"], "81657": ["Activation of G protein gated Potassium channels", "G alpha (i) signalling events", "Class C/3 (Metabotropic glutamate/pheromone receptors)", "GABA B receptor activation", "Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "81663": ["G alpha (12/13) signalling events", "Thrombin signalling through proteinase activated receptors (PARs)"], "81664": ["PLC beta mediated events", "Adenylate cyclase inhibitory pathway", "G-protein activation", "ADP signalling through P2Y purinoceptor 12", "Adrenaline,noradrenaline inhibits insulin secretion", "G alpha (i) signalling events", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"], "81667": ["Activation of G protein gated Potassium channels", "G-protein activation", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion", "ADP signalling through P2Y purinoceptor 12", "G beta:gamma signalling through PI3Kgamma", "Prostacyclin signalling through prostacyclin receptor", "Adrenaline,noradrenaline inhibits insulin secretion", "Ca2+ pathway", "G alpha (q) signalling events", "G alpha (12/13) signalling events", "G beta:gamma signalling through PLC beta", "G alpha (s) signalling events", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "G alpha (z) signalling events", "Glucagon-type ligand receptors", "Thromboxane signalling through TP receptor", "Vasopressin regulates renal water homeostasis via Aquaporins", "Thrombin signalling through proteinase activated receptors (PARs)", "Presynaptic function of Kainate receptors", "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding", "G beta:gamma signalling through BTK", "G beta:gamma signalling through CDC42", "Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits"], "81670": ["Amino acid synthesis and interconversion (transamination)"], "81674": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE", "Estrogen-dependent gene expression"], "81676": ["Histidine catabolism"], "81677": ["Synthesis of IP3 and IP4 in the cytosol"], "81679": ["Adherens junctions interactions", "VEGFR2 mediated vascular permeability", "Neutrophil degranulation", "Keratinization", "Formation of the cornified envelope"], "81680": ["IL-6-type cytokine receptor ligand interactions"], "81682": ["Keratan sulfate biosynthesis", "Keratan sulfate degradation", "Integrin cell surface interactions"], "81683": ["Cell surface interactions at the vascular wall", "Neutrophil degranulation"], "81707": ["Collagen degradation", "Degradation of the extracellular matrix", "Activation of Matrix Metalloproteinases"], "81708": ["Branched-chain amino acid catabolism"], "81716": ["Gamma-carboxylation of protein precursors"], "81717": ["Repression of WNT target genes"], "81718": ["Degradation of cysteine and homocysteine"], "81722": ["TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "Advanced glycosylation endproduct receptor signaling", "TRAF6 mediated NF-kB activation"], "81728": ["Respiratory electron transport", "Complex I biogenesis"], "81729": ["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "81732": ["Regulation of actin dynamics for phagocytic cup formation", "EPHB-mediated forward signaling", "RHO GTPases Activate WASPs and WAVEs", "Clathrin-mediated endocytosis"], "81736": ["Activation of NF-kappaB in B cells", "RIP-mediated NFkB activation via ZBP1", "Regulated proteolysis of p75NTR", "Downstream TCR signaling", "NF-kB is activated and signals survival", "FCERI mediated NF-kB activation", "DEx/H-box helicases activate type I IFN and inflammatory cytokines production ", "PKMTs methylate histone lysines", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "Interleukin-1 processing", "CLEC7A (Dectin-1) signaling", "CD209 (DC-SIGN) signaling", "MAP3K8 (TPL2)-dependent MAPK1/3 activation", "Neutrophil degranulation", "Interleukin-1 signaling", "TRAF6 mediated NF-kB activation"], "81737": ["NTF3 activates NTRK3 signaling", "Activated NTRK3 signals through PLCG1", "Activated NTRK3 signals through PI3K"], "81738": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "SUMOylation of DNA damage response and repair proteins", "Nuclear Pore Complex (NPC) Disassembly", "Regulation of HSF1-mediated heat shock response", "SUMOylation of DNA replication proteins", "RHO GTPases Activate Formins", "Mitotic Prometaphase"], "81739": ["Elevation of cytosolic Ca2+ levels", "Platelet homeostasis"], "81740": ["Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "AURKA Activation by TPX2"], "81743": ["cGMP effects", "G alpha (s) signalling events"], "81744": ["G alpha (s) signalling events"], "81745": ["GPVI-mediated activation cascade", "PIP3 activates AKT signaling", "Activation of AKT2", "Downstream TCR signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated NF-kB activation", "Integrin alphaIIb beta3 signaling", "CD28 dependent PI3K/Akt signaling", "G beta:gamma signalling through PI3Kgamma", "VEGFR2 mediated vascular permeability", "VEGFR2 mediated cell proliferation", "CLEC7A (Dectin-1) signaling", "RHO GTPases activate PKNs"], "81747": ["Synthesis of PIPs at the Golgi membrane"], "81749": ["Effects of PIP2 hydrolysis"], "81750": ["Platelet degranulation ", "Common Pathway of Fibrin Clot Formation", "Gamma-carboxylation of protein precursors", "Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "Removal of aminoterminal propeptides from gamma-carboxylated proteins", "Cell surface interactions at the vascular wall"], "81751": ["Regulated proteolysis of p75NTR", "NRIF signals cell death from the nucleus", "NOTCH3 Activation and Transmission of Signal to the Nucleus"], "81752": ["Prostanoid ligand receptors", "G alpha (s) signalling events"], "81754": ["Golgi Cisternae Pericentriolar Stack Reorganization", "COPII-mediated vesicle transport", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "81755": ["RAB geranylgeranylation"], "81756": ["RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "81757": ["Translocation of SLC2A4 (GLUT4) to the plasma membrane"], "81759": ["Synthesis of UDP-N-acetyl-glucosamine"], "81762": ["Apoptotic cleavage of cellular proteins", "EPHB-mediated forward signaling", "G alpha (12/13) signalling events", "Sema4D induced cell migration and growth-cone collapse", "VEGFA-VEGFR2 Pathway", "RHO GTPases Activate ROCKs", "Neutrophil degranulation"], "81765": ["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "81767": ["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "81769": ["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "81772": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "81773": ["L13a-mediated translational silencing of Ceruloplasmin expression", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "81778": ["Dissolution of Fibrin Clot"], "81780": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "81781": ["mRNA Splicing - Major Pathway"], "81785": ["Formation of RNA Pol II elongation complex ", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "Regulation of TP53 Activity through Phosphorylation", "RNA Polymerase II Transcription Elongation"], "81802": ["Other interleukin signaling"], "81805": ["Sulfide oxidation to sulfate"], "81807": ["Formation of RNA Pol II elongation complex ", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "RNA Polymerase II Pre-transcription Events", "TP53 Regulates Transcription of DNA Repair Genes", "RNA Polymerase II Transcription Elongation", "Neddylation", "Antigen processing: Ubiquitination & Proteasome degradation"], "81809": ["Platelet degranulation ", "Molecules associated with elastic fibres"], "81810": ["Downregulation of TGF-beta receptor signaling", "TGF-beta receptor signaling activates SMADs", "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)"], "81812": ["Nuclear Receptor transcription pathway", "SUMOylation of intracellular receptors"], "81815": ["Antigen processing: Ubiquitination & Proteasome degradation"], "81816": ["Recognition of DNA damage by PCNA-containing replication complex", "Synthesis of active ubiquitin: roles of E1 and E2 enzymes", "E3 ubiquitin ligases ubiquitinate target proteins", "Antigen processing: Ubiquitination & Proteasome degradation"], "81821": ["Effects of PIP2 hydrolysis"], "81822": ["Gap junction degradation", "Formation of annular gap junctions", "Regulation of actin dynamics for phagocytic cup formation", "EPHB-mediated forward signaling", "Adherens junctions interactions", "Recycling pathway of L1", "VEGFA-VEGFR2 Pathway", "Interaction between L1 and Ankyrins", "Cell-extracellular matrix interactions", "B-WICH complex positively regulates rRNA expression", "RHO GTPases activate IQGAPs", "RHO GTPases Activate WASPs and WAVEs", "RHO GTPases Activate Formins", "MAP2K and MAPK activation", "UCH proteinases", "DNA Damage Recognition in GG-NER", "Clathrin-mediated endocytosis"], "81826": ["Sodium-coupled phosphate cotransporters"], "81827": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "81829": ["Citric acid cycle (TCA cycle)"], "81830": ["Vasopressin regulates renal water homeostasis via Aquaporins", "Anchoring of the basal body to the plasma membrane", "VxPx cargo-targeting to cilium", "TBC/RABGAPs", "RAB geranylgeranylation"], "81859": ["Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway"], "81869": ["Glutathione conjugation"], "81917": ["Golgi Associated Vesicle Biogenesis", "Clathrin-mediated endocytosis"], "81918": ["TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "Tight junction interactions"], "81920": ["Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "E3 ubiquitin ligases ubiquitinate target proteins", "Neddylation", "Peroxisomal protein import", "Antigen processing: Ubiquitination & Proteasome degradation"], "81921": ["EGFR downregulation", "Negative regulation of MET activity", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "81922": ["EGFR downregulation", "Negative regulation of MET activity", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "81925": ["Synthesis of PI"], "83427": ["Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "TNFR1-mediated ceramide production"], "83462": ["Neutrophil degranulation"], "83470": ["Degradation of the extracellular matrix", "Collagen biosynthesis and modifying enzymes", "Anchoring fibril formation", "HDL assembly"], "83474": ["Mitochondrial transcription initiation"], "83477": ["Downstream TCR signaling", "FCERI mediated NF-kB activation", "CLEC7A (Dectin-1) signaling", "E3 ubiquitin ligases ubiquitinate target proteins"], "83497": ["Apoptotic cleavage of cell adhesion  proteins"], "83499": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "83502": ["Degradation of the extracellular matrix", "Integrin cell surface interactions", "Apoptotic cleavage of cell adhesion  proteins", "Adherens junctions interactions", "RHO GTPases activate IQGAPs"], "83503": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "B-WICH complex positively regulates rRNA expression", "Transcriptional regulation by small RNAs", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "FGFR2 alternative splicing", "RNA polymerase II transcribes snRNA genes", "mRNA Capping", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway", "Processing of Capped Intron-Containing Pre-mRNA", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase I Transcription Termination", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "RNA Pol II CTD phosphorylation and interaction with CE", "Estrogen-dependent gene expression"], "83505": ["Sialic acid metabolism"], "83509": ["Basigin interactions", "Amino acid transport across the plasma membrane"], "83510": ["L1CAM interactions"], "83518": ["Peptide ligand-binding receptors", "G alpha (i) signalling events"], "83519": ["ABC transporters in lipid homeostasis"], "83527": ["Caspase-mediated cleavage of cytoskeletal proteins", "Neurexins and neuroligins", "Neutrophil degranulation"], "83529": ["Pink/Parkin Mediated Mitophagy", "Ub-specific processing proteases", "Pyruvate metabolism"], "83531": ["Ub-specific processing proteases"], "83535": ["ATP sensitive Potassium channels", "ABC-family proteins mediated transport", "Regulation of insulin secretion", "Ion homeostasis"], "83537": ["Glycosphingolipid metabolism", "TNFR1-mediated ceramide production"], "83567": ["Peptide ligand-binding receptors", "G alpha (q) signalling events", "G alpha (i) signalling events", "BBSome-mediated cargo-targeting to cilium"], "83571": ["SCF(Skp2)-mediated degradation of p27/p21", "AKT phosphorylates targets in the cytosol", "Senescence-Associated Secretory Phenotype (SASP)", "DNA Damage/Telomere Stress Induced Senescence", "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "Cyclin E associated events during G1/S transition ", "Cyclin D associated events in G1", "p53-Dependent G1 DNA Damage Response", "Cyclin A:Cdk2-associated events at S phase entry", "PTK6 Regulates Cell Cycle"], "83572": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "RHO GTPases Activate Formins", "COPI-independent Golgi-to-ER retrograde traffic", "Mitotic Prometaphase", "AURKA Activation by TPX2"], "83574": ["Nuclear Receptor transcription pathway", "Signaling by Retinoic Acid"], "83576": ["Golgi Associated Vesicle Biogenesis"], "83577": ["Integrin cell surface interactions"], "83580": ["Common Pathway of Fibrin Clot Formation", "Cell surface interactions at the vascular wall"], "83584": ["Caspase-mediated cleavage of cytoskeletal proteins", "Breakdown of the nuclear lamina"], "83585": ["Purine catabolism"], "83586": ["Estrogen-dependent gene expression"], "83588": ["Voltage gated Potassium channels", "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion"], "83612": ["Transport of inorganic cations/anions and amino acids/oligopeptides", "GABA synthesis, release, reuptake and degradation"], "83613": ["Unblocking of NMDA receptors, glutamate binding and activation", "RAF/MAP kinase cascade"], "83614": ["SUMOylation of transcription factors", "SUMOylation of transcription cofactors", "SUMOylation of intracellular receptors", "Formation of Incision Complex in GG-NER"], "83620": ["RHO GTPases activate CIT"], "83626": ["Glycosphingolipid metabolism"], "83627": ["O-linked glycosylation of mucins"], "83681": ["Neddylation"], "83686": ["Activation of the phototransduction cascade", "Inactivation, recovery and regulation of the phototransduction cascade", "VxPx cargo-targeting to cilium"], "83687": ["Beta defensins", "Defensins"], "83688": ["Pentose phosphate pathway"], "83711": ["Glycoprotein hormones"], "83712": ["PRC2 methylates histones and DNA", "Oxidative Stress Induced Senescence", "PKMTs methylate histone lysines", "HATs acetylate histones", "RMTs methylate histone arginines", "Deposition of new CENPA-containing nucleosomes at the centromere", "Regulation of TP53 Activity through Acetylation", "RNA Polymerase I Transcription Initiation", "Regulation of PTEN gene transcription", "Neddylation", "Transcriptional Regulation by E2F6"], "83717": ["Keratan sulfate biosynthesis", "Keratan sulfate degradation"], "83721": ["WNT mediated activation of DVL", "PCP/CE pathway", "Degradation of DVL", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "RHO GTPases Activate Formins"], "83722": ["TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"], "83724": ["Recycling of bile acids and salts", "Synthesis of bile acids and bile salts", "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "Synthesis of bile acids and bile salts via 27-hydroxycholesterol", "Endogenous sterols", "HATs acetylate histones", "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)", "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "Estrogen-dependent gene expression"], "83727": ["Degradation of the extracellular matrix", "Elastic fibre formation", "Molecules associated with elastic fibres", "Integrin cell surface interactions", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "83731": ["Ca2+ activated K+ channels"], "83764": ["Synaptic adhesion-like molecules"], "83765": ["Axonal growth inhibition (RHOA activation)"], "83781": ["Neutrophil degranulation"], "83782": ["Interconversion of nucleotide di- and triphosphates", "Neutrophil degranulation"], "83783": ["Cytosolic sulfonation of small molecules"], "83784": ["Glyoxylate metabolism and glycine degradation"], "83785": ["Platelet degranulation ", "VEGF ligand-receptor interactions", "VEGF binds to VEGFR leading to receptor dimerization", "VEGFA-VEGFR2 Pathway", "VEGFR2 mediated cell proliferation"], "83789": ["L13a-mediated translational silencing of Ceruloplasmin expression", "RMTs methylate histone arginines", "Major pathway of rRNA processing in the nucleolus and cytosol", "Translation initiation complex formation", "Formation of a pool of free 40S subunits", "Formation of the ternary complex, and subsequently, the 43S complex", "Ribosomal scanning and start codon recognition", "GTP hydrolysis and joining of the 60S ribosomal subunit", "Protein methylation", "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"], "83792": ["Fatty acyl-CoA biosynthesis"], "83799": ["Neutrophil degranulation"], "83800": ["Retrograde neurotrophin signalling", "Gap junction degradation", "Formation of annular gap junctions", "MHC class II antigen presentation", "Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis", "Recycling pathway of L1", "WNT5A-dependent internalization of FZD4", "WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "VLDLR internalisation and degradation", "LDL clearance"], "83803": ["Macroautophagy", "Energy dependent regulation of mTOR by LKB1-AMPK", "TP53 Regulates Metabolic Genes", "Regulation of TP53 Activity through Phosphorylation"], "83805": ["Signaling by ERBB2", "Nuclear signaling by ERBB4", "PIP3 activates AKT signaling", "Signaling by SCF-KIT", "Regulation of KIT signaling", "Signaling by EGFR", "GAB1 signalosome", "Downstream signal transduction", "c-src mediated regulation of Cx43 function and closure of gap junctions", "FCGR activation", "Integrin alphaIIb beta3 signaling", "GRB2:SOS provides linkage to MAPK signaling for Integrins ", "p130Cas linkage to MAPK signaling for integrins", "CD28 co-stimulation", "CTLA4 inhibitory signaling", "EPHB-mediated forward signaling", "EPHA-mediated growth cone collapse", "Ephrin signaling", "EPH-ephrin mediated repulsion of cells", "ADP signalling through P2Y purinoceptor 1", "G alpha (i) signalling events", "DCC mediated attractive signaling", "GP1b-IX-V activation signalling", "VEGFA-VEGFR2 Pathway", "Thrombin signalling through proteinase activated receptors (PARs)", "RHO GTPases Activate Formins", "RAF activation", "MAP2K and MAPK activation", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Cyclin D associated events in G1", "RET signaling", "MET activates PTK2 signaling", "Receptor Mediated Mitophagy", "Regulation of RUNX3 expression and activity", "Activated NTRK3 signals through PI3K"], "83808": ["Glucuronidation"], "83810": ["TRP channels"], "83826": ["Nuclear Receptor transcription pathway", "SUMOylation of intracellular receptors"], "83828": ["RNA Polymerase II Pre-transcription Events", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "Estrogen-dependent gene expression"], "83830": ["RNA Polymerase II Pre-transcription Events", "RNA polymerase II transcribes snRNA genes", "RNA Polymerase II Promoter Escape", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "Estrogen-dependent gene expression"], "83833": ["RMTs methylate histone arginines", "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"], "83836": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Regulation of PLK1 Activity at G2/M Transition", "Loss of Nlp from mitotic centrosomes", "Recruitment of mitotic centrosome proteins and complexes", "Loss of proteins required for interphase microtubule organization from the centrosome", "Recruitment of NuMA to mitotic centrosomes", "Anchoring of the basal body to the plasma membrane", "RHO GTPases Activate Formins", "Mitotic Prometaphase", "AURKA Activation by TPX2"], "83837": ["Downregulation of TGF-beta receptor signaling"], "83838": ["Molecules associated with elastic fibres"], "83840": ["mTORC1-mediated signalling"], "83841": ["Ephrin signaling", "Neurofascin interactions", "Neutrophil degranulation"], "83842": ["Beta-oxidation of pristanoyl-CoA", "Peroxisomal protein import"], "84006": ["Pre-NOTCH Transcription and Translation", "p75NTR recruits signalling complexes", "Tight junction interactions"], "84007": ["Peptide ligand-binding receptors", "G alpha (i) signalling events", "Neutrophil degranulation", "Regulation of Complement cascade"], "84009": ["NRAGE signals death through JNK", "Rho GTPase cycle", "EPHB-mediated forward signaling", "G alpha (q) signalling events", "MAPK6/MAPK4 signaling"], "84013": ["Androgen biosynthesis", "Synthesis of very long-chain fatty acyl-CoAs"], "84022": ["G alpha (q) signalling events"], "84023": ["Prostanoid ligand receptors", "G alpha (s) signalling events"], "84024": ["Synthesis of 5-eicosatetraenoic acids"], "84026": ["HSP90 chaperone cycle for steroid hormone receptors (SHR)"], "84027": ["Degradation of beta-catenin by the destruction complex", "Beta-catenin phosphorylation cascade", "CRMPs in Sema3A signaling", "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "B-WICH complex positively regulates rRNA expression"], "84029": ["Peroxisomal lipid metabolism", "Peroxisomal protein import"], "84032": ["Collagen degradation", "Extracellular matrix organization", "Collagen biosynthesis and modifying enzymes", "Signaling by PDGF", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "Non-integrin membrane-ECM interactions", "ECM proteoglycans", "NCAM1 interactions", "MET activates PTK2 signaling", "Collagen chain trimerization"], "84348": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "84350": ["PRC2 methylates histones and DNA", "SUMOylation of DNA methylation proteins"], "84351": ["Activation of NF-kappaB in B cells", "NOD1/2 Signaling Pathway", "RIP-mediated NFkB activation via ZBP1", "Downstream TCR signaling", "p75NTR recruits signalling complexes", "NF-kB is activated and signals survival", "FCERI mediated NF-kB activation", "TAK1 activates NFkB by phosphorylation and activation of IKKs complex", "Regulation of TNFR1 signaling", "TNFR1-induced NFkappaB signaling pathway", "CLEC7A (Dectin-1) signaling", "MAP3K8 (TPL2)-dependent MAPK1/3 activation", "Interleukin-1 signaling", "TRAF6 mediated NF-kB activation", "IRAK1 recruits IKK complex", "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation"], "84353": ["Degradation of beta-catenin by the destruction complex", "Beta-catenin phosphorylation cascade", "TCF dependent signaling in response to WNT", "Formation of the beta-catenin:TCF transactivating complex", "LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "Apoptotic cleavage of cell adhesion  proteins", "CDO in myogenesis", "Deactivation of the beta-catenin transactivating complex", "Ca2+ pathway", "Adherens junctions interactions", "VEGFR2 mediated vascular permeability", "RHO GTPases activate IQGAPs", "RUNX3 regulates WNT signaling"], "84355": ["Ion influx/efflux at host-pathogen interface"], "84357": ["EGFR downregulation", "Negative regulation of MET activity", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "Reelin signalling pathway", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "84358": ["EPH-Ephrin signaling", "EPHA-mediated growth cone collapse", "EPH-ephrin mediated repulsion of cells"], "84379": ["Neutrophil degranulation", "COPI-independent Golgi-to-ER retrograde traffic", "Retrograde transport at the Trans-Golgi-Network", "TBC/RABGAPs", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "84380": ["Hedgehog ligand biogenesis", "Release of Hh-Np from the secreting cell", "Ligand-receptor interactions", "Activation of SMO"], "84385": ["Nuclear Receptor transcription pathway", "SUMOylation of intracellular receptors"], "84388": ["Interleukin-18 signaling"], "84389": ["Formation of RNA Pol II elongation complex ", "Formation of the Early Elongation Complex", "Formation of Incision Complex in GG-NER", "RNA Polymerase II Pre-transcription Events", "Formation of TC-NER Pre-Incision Complex", "Dual incision in TC-NER", "Gap-filling DNA repair synthesis and ligation in TC-NER", "TP53 Regulates Transcription of DNA Repair Genes", "Cyclin A/B1/B2 associated events during G2/M transition", "mRNA Capping", "RNA Polymerase I Transcription Initiation", "RNA Polymerase I Promoter Escape", "RNA Polymerase II Promoter Escape", "RNA Polymerase I Chain Elongation", "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening", "RNA Polymerase I Transcription Termination", "RNA Polymerase II Transcription Initiation", "RNA Polymerase II Transcription Elongation", "RNA Polymerase II Transcription Initiation And Promoter Clearance", "RNA Pol II CTD phosphorylation and interaction with CE", "RUNX1 regulates transcription of genes involved in differentiation of HSCs"], "84392": ["MHC class II antigen presentation", "Hedgehog 'off' state", "Intraflagellar transport", "Activation of SMO", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "84393": ["MHC class II antigen presentation", "Recycling pathway of L1", "COPI-dependent Golgi-to-ER retrograde traffic", "Kinesins"], "84396": ["SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription"], "84399": ["Hedgehog ligand biogenesis", "Release of Hh-Np from the secreting cell", "Ligand-receptor interactions", "Activation of SMO"], "84400": ["Keratan sulfate biosynthesis", "Keratan sulfate degradation"], "84401": ["mRNA Splicing - Major Pathway"], "84403": ["Gap junction assembly"], "84404": ["snRNP Assembly"], "84407": ["Adherens junctions interactions"], "84408": ["Adherens junctions interactions"], "84420": ["PKA activation", "Adenylate cyclase activating pathway", "Adenylate cyclase inhibitory pathway", "G alpha (z) signalling events", "Hedgehog 'off' state"], "84422": ["RAF/MAP kinase cascade", "RET signaling"], "84423": ["RAF/MAP kinase cascade", "RET signaling"], "84424": ["Formation of the beta-catenin:TCF transactivating complex", "Deactivation of the beta-catenin transactivating complex", "Repression of WNT target genes", "Estrogen-dependent gene expression"], "84427": ["GRB7 events in ERBB2 signaling", "Signaling by SCF-KIT", "Downstream signal transduction", "Tie2 Signaling", "RET signaling"], "84428": ["MHC class II antigen presentation", "HSP90 chaperone cycle for steroid hormone receptors (SHR)", "COPI-mediated anterograde transport", "COPI-independent Golgi-to-ER retrograde traffic"], "84429": ["TWIK-releated acid-sensitive K+ channel (TASK)", "Phase 4 - resting membrane potential"], "84430": ["O-linked glycosylation"], "84431": ["Glycosphingolipid metabolism", "Neutrophil degranulation"], "84468": ["Chondroitin sulfate biosynthesis"], "84470": ["Synthesis of PA", "Plasmalogen biosynthesis", "Peroxisomal protein import"], "84473": ["snRNP Assembly"], "84475": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "84478": ["Translesion Synthesis by POLH", "Ub-specific processing proteases"], "84482": ["AKT phosphorylates targets in the nucleus", "AKT-mediated inactivation of FOXO1A", "MAPK6/MAPK4 signaling", "Regulation of localization of FOXO transcription factors", "Regulation of FOXO transcriptional activity by acetylation", "FOXO-mediated transcription of cell cycle genes"], "84484": ["Bicarbonate transporters"], "84486": ["B-WICH complex positively regulates rRNA expression", "mRNA Splicing - Major Pathway", "mRNA Splicing - Minor Pathway"], "84487": ["Organic anion transporters"], "84488": ["Phase 0 - rapid depolarisation"], "84489": ["PI3K Cascade", "PIP3 activates AKT signaling", "FGFR3b ligand binding and activation", "FGFR3c ligand binding and activation", "Phospholipase C-mediated cascade; FGFR3", "SHC-mediated cascade:FGFR3", "FRS-mediated FGFR3 signaling", "PI-3K cascade:FGFR3", "Negative regulation of FGFR3 signaling", "RAF/MAP kinase cascade", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"], "84490": ["POLB-Dependent Long Patch Base Excision Repair", "PCNA-Dependent Long Patch Base Excision Repair", "HDR through MMEJ (alt-NHEJ)", "Removal of the Flap Intermediate"], "84491": ["Platelet degranulation ", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Neutrophil degranulation", "Post-translational protein phosphorylation"], "84492": ["Signaling by SCF-KIT", "FCERI mediated Ca+2 mobilization", "Interleukin-3, Interleukin-5 and GM-CSF signaling"], "84493": ["FMO oxidises nucleophiles"], "84494": ["TRP channels"], "84495": ["Resolution of AP sites via the single-nucleotide replacement pathway", "APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway", "HDR through MMEJ (alt-NHEJ)", "Gap-filling DNA repair synthesis and ligation in TC-NER"], "84550": ["Sodium/Calcium exchangers"], "84551": ["Basigin interactions", "Amino acid transport across the plasma membrane"], "84556": ["Serotonin Neurotransmitter Release Cycle", "Norepinephrine Neurotransmitter Release Cycle", "Glutamate Neurotransmitter Release Cycle", "Dopamine Neurotransmitter Release Cycle", "Acetylcholine Neurotransmitter Release Cycle", "GABA synthesis, release, reuptake and degradation"], "84575": ["alpha-linolenic acid (ALA) metabolism"], "84576": ["G0 and Early G1", "Formation of the beta-catenin:TCF transactivating complex", "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "Deactivation of the beta-catenin transactivating complex", "SUMOylation of chromatin organization proteins", "Regulation of TP53 Activity through Acetylation", "RNA Polymerase I Transcription Initiation", "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "Regulation of PTEN gene transcription", "Estrogen-dependent gene expression", "Regulation of MECP2 expression and activity", "Factors involved in megakaryocyte development and platelet production"], "84577": ["SUMOylation of chromatin organization proteins", "Regulation of TP53 Activity through Acetylation", "RNA Polymerase I Transcription Initiation", "Regulation of PTEN gene transcription", "Regulation of MECP2 expression and activity", "Factors involved in megakaryocyte development and platelet production"], "84581": ["HSF1 activation", "Cilium Assembly"], "84582": ["SUMOylation of DNA damage response and repair proteins"], "84583": ["G alpha (q) signalling events"], "84584": ["MAPK6/MAPK4 signaling", "Estrogen-dependent gene expression"], "84586": ["Neutrophil degranulation"], "84589": ["Retrograde transport at the Trans-Golgi-Network", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "84590": ["Platelet degranulation ", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "84594": ["Mitochondrial iron-sulfur cluster biogenesis", "Molybdenum cofactor biosynthesis"], "84595": ["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "84596": ["Metabolism of polyamines"], "84598": ["Interleukin-6 signaling", "MAPK3 (ERK1) activation", "MAPK1 (ERK2) activation", "ISG15 antiviral mechanism", "Interleukin-7 signaling", "RAF/MAP kinase cascade", "Interleukin-10 signaling", "Interleukin-4 and Interleukin-13 signaling", "IL-6-type cytokine receptor ligand interactions", "Interferon gamma signaling", "Regulation of IFNG signaling", "Interleukin-20 family signaling", "Interleukin-15 signaling", "Interleukin-35 Signalling", "Interleukin-9 signaling", "Interleukin-2 signaling", "Interleukin-12 signaling", "Interleukin-27 signaling", "Interleukin-21 signaling", "Interferon alpha/beta signaling", "Interleukin receptor SHC signaling", "Regulation of IFNA signaling"], "84599": ["COPII-mediated vesicle transport", "Cargo concentration in the ER", "COPI-mediated anterograde transport", "COPI-dependent Golgi-to-ER retrograde traffic"], "84608": ["Recycling of bile acids and salts", "Transport of organic anions"], "85237": ["RAB geranylgeranylation"], "85238": ["Synthesis of PIPs at the plasma membrane", "Synthesis of IP2, IP, and Ins in the cytosol", "Synthesis of IP3 and IP4 in the cytosol", "Clathrin-mediated endocytosis"], "85239": ["Beta-oxidation of very long chain fatty acids", "Peroxisomal protein import"], "85243": ["PI3K Cascade", "IRS-mediated signalling", "GPVI-mediated activation cascade", "PIP3 activates AKT signaling", "Synthesis of PIPs at the plasma membrane", "Downstream signal transduction", "PI3K/AKT activation", "Downstream TCR signaling", "Role of phospholipids in phagocytosis", "Tie2 Signaling", "DAP12 signaling", "Role of LAT2/NTAL/LAB on calcium mobilization", "VEGFA-VEGFR2 Pathway", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "RET signaling", "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "Interleukin receptor SHC signaling", "Regulation of signaling by CBL"], "85245": ["Sensing of DNA Double Strand Breaks"], "85251": ["Collagen degradation", "Activation of Matrix Metalloproteinases", "Collagen biosynthesis and modifying enzymes", "Assembly of collagen fibrils and other multimeric structures", "Integrin cell surface interactions", "Laminin interactions", "Collagen chain trimerization"], "85252": ["Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "Separation of Sister Chromatids", "Resolution of Sister Chromatid Cohesion", "Deactivation of the beta-catenin transactivating complex", "HuR (ELAVL1) binds and stabilizes mRNA", "RHO GTPases Activate Formins", "MAPK6/MAPK4 signaling", "Mitotic Prometaphase", "Cyclin A/B1/B2 associated events during G2/M transition"], "85253": ["Platelet degranulation ", "Degradation of the extracellular matrix", "Activation of Matrix Metalloproteinases", "Signaling by PDGF", "Dissolution of Fibrin Clot"], "85254": ["Synthesis of PC", "Transport of bile salts and organic acids, metal ions and amine compounds", "Choline catabolism"], "85255": ["Alpha-oxidation of phytanate", "Peroxisomal protein import"], "85256": ["Cellular hexose transport", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "85258": ["VxPx cargo-targeting to cilium"], "85260": ["Phosphate bond hydrolysis by NTPDase proteins"], "85261": ["Mitochondrial transcription termination"], "85263": ["The fatty acid cycling model", "The proton buffering model"], "85265": ["Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "Regulation of PLK1 Activity at G2/M Transition"], "85268": ["Histamine receptors", "G alpha (i) signalling events"], "85272": ["Molecules associated with elastic fibres"], "85274": ["Neutrophil degranulation"], "85311": ["Acyl chain remodelling of PS"], "85384": ["NRAGE signals death through JNK", "Rho GTPase cycle", "Interleukin-15 signaling"], "85385": ["SHC1 events in ERBB2 signaling", "SHC1 events in ERBB4 signaling", "Signalling to RAS", "SHC1 events in EGFR signaling", "Tie2 Signaling", "DAP12 signaling", "SHC-related events triggered by IGF1R", "Role of LAT2/NTAL/LAB on calcium mobilization", "FCERI mediated MAPK activation", "FCERI mediated Ca+2 mobilization", "Integrin alphaIIb beta3 signaling", "Interleukin-3, Interleukin-5 and GM-CSF signaling", "SHC-mediated cascade:FGFR1", "SHC-mediated cascade:FGFR2", "SHC-mediated cascade:FGFR3", "SHC-mediated cascade:FGFR4", "RAF/MAP kinase cascade", "Signal attenuation", "Insulin receptor signalling cascade", "MET activates RAS signaling", "RET signaling", "Interleukin-15 signaling", "Interleukin-2 signaling", "Erythropoietin activates RAS", "Interleukin receptor SHC signaling"], "85420": ["Apoptotic cleavage of cellular proteins", "Effects of PIP2 hydrolysis", "Downstream TCR signaling", "FCERI mediated NF-kB activation", "Netrin-1 signaling"], "85421": ["Sphingolipid de novo biosynthesis"], "85423": ["UCH proteinases", "DNA Damage Recognition in GG-NER"], "85424": ["RUNX1 regulates transcription of genes involved in interleukin signaling"], "85426": ["Acetylcholine Neurotransmitter Release Cycle", "Transport of bile salts and organic acids, metal ions and amine compounds"], "85428": ["Rho GTPase cycle", "RHO GTPases regulate CFTR trafficking"], "85431": ["Detoxification of Reactive Oxygen Species"], "85432": ["Major pathway of rRNA processing in the nucleolus and cytosol"], "85434": ["mRNA Splicing - Major Pathway"], "85435": ["Signaling by BMP"], "85471": ["Ub-specific processing proteases", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Estrogen-dependent gene expression", "Factors involved in megakaryocyte development and platelet production"], "85491": ["Clathrin derived vesicle budding", "Lysosome Vesicle Biogenesis", "Golgi Associated Vesicle Biogenesis", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis", "Interleukin-12 signaling"], "85492": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "Neutrophil degranulation", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "85493": ["ABC-family proteins mediated transport"], "89776": ["Organic anion transport"], "89784": ["Cholesterol biosynthesis"], "89804": ["Tie2 Signaling", "RAF/MAP kinase cascade"], "89805": ["Tie2 Signaling"], "89808": ["Chemokine receptors bind chemokines", "G alpha (i) signalling events"], "89810": ["The retinoid cycle in cones (daylight vision)", "G alpha (i) signalling events", "Opsins"], "89811": ["Platelet degranulation ", "VEGF ligand-receptor interactions", "VEGF binds to VEGFR leading to receptor dimerization"], "89812": ["Synthesis of PIPs at the plasma membrane", "PI5P Regulates TP53 Acetylation", "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "Synthesis of PIPs in the nucleus"], "89814": ["TNFs bind their physiological receptors"], "89816": ["Golgi Associated Vesicle Biogenesis", "Cargo recognition for clathrin-mediated endocytosis", "Clathrin-mediated endocytosis"], "89817": ["Prolactin receptor signaling", "Growth hormone receptor signaling", "Factors involved in megakaryocyte development and platelet production"], "89819": ["mRNA Splicing - Major Pathway"], "89820": ["RMTs methylate histone arginines", "Protein methylation"], "89821": ["TRP channels", "Ion homeostasis", "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"], "89823": ["Effects of PIP2 hydrolysis", "Elevation of cytosolic Ca2+ levels", "TRP channels"], "89824": ["Neutrophil degranulation"], "89826": ["The canonical retinoid cycle in rods (twilight vision)"], "89827": ["Cleavage of Growing Transcript in the Termination Region ", "Transport of Mature mRNA derived from an Intron-Containing Transcript", "mRNA 3'-end processing"], "89829": ["Interleukin-6 signaling", "Interferon gamma signaling", "Regulation of IFNG signaling", "PTK6 Activates STAT3", "Neddylation", "Interferon alpha/beta signaling", "Antigen processing: Ubiquitination & Proteasome degradation"], "89830": ["Hedgehog 'off' state", "Ligand-receptor interactions", "Hedgehog 'on' state", "Activation of SMO"], "89833": ["Histidine catabolism"], "89841": ["Synthesis of PE"], "89842": ["ATF6 (ATF6-alpha) activates chaperones", "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "Post-translational protein phosphorylation"], "89868": ["COPII-mediated vesicle transport"], "93646": ["COPII-mediated vesicle transport", "MHC class II antigen presentation", "Antigen Presentation: Folding, assembly and peptide loading of class I MHC"], "94165": ["Formation of Senescence-Associated Heterochromatin Foci (SAHF)"], "94167": ["Detoxification of Reactive Oxygen Species", "Neutrophil degranulation"], "94170": ["ROS, RNS production in phagocytes", "Insulin receptor recycling", "Transferrin endocytosis and recycling", "Ion channel transport"], "94172": ["Transport of fatty acids"], "94173": ["Citric acid cycle (TCA cycle)"], "94189": ["COPI-mediated anterograde transport", "Intra-Golgi traffic"], "94193": ["Regulation of TNFR1 signaling", "RAB GEFs exchange GTP for GDP on RABs"], "94195": ["RHO GTPases Activate NADPH Oxidases", "Neutrophil degranulation", "Metal sequestration by antimicrobial proteins"], "94197": ["Neutrophil degranulation", "RAB geranylgeranylation", "RAB GEFs exchange GTP for GDP on RABs"], "94198": ["Autodegradation of Cdh1 by Cdh1:APC/C", "UCH proteinases", "Ub-specific processing proteases", "Neutrophil degranulation", "CDT1 association with the CDC6:ORC:origin complex", "Neddylation"], "94199": ["Synthesis of Leukotrienes (LT) and Eoxins (EX)"], "94201": ["SCF(Skp2)-mediated degradation of p27/p21", "Oxidative Stress Induced Senescence", "Senescence-Associated Secretory Phenotype (SASP)", "Oncogene Induced Senescence", "RMTs methylate histone arginines", "Ubiquitin-dependent degradation of Cyclin D1", "Cyclin D associated events in G1", "PTK6 Regulates Cell Cycle", "Transcriptional regulation by RUNX2"], "94203": ["VEGF ligand-receptor interactions", "VEGF binds to VEGFR leading to receptor dimerization"], "94204": ["Peptide ligand-binding receptors"], "94267": ["Synthesis of pyrophosphates in the cytosol"], "94268": ["EPH-Ephrin signaling", "EPHA-mediated growth cone collapse", "EPH-ephrin mediated repulsion of cells"], "94271": ["Formation of ATP by chemiosmotic coupling", "Cristae formation"], "94273": ["Reactions specific to the complex N-glycan synthesis pathway"]}}